Clinical trial NCT06803446: Effects of Circadian Rhythm on Glycemic Regulation During Continuous Moderate Exercise and Intense Intermittent Disease in Adolescents Living with Type 1 Diabetes
Official title: Effets Du Rythme Circadien Sur La Régulation Glycémique Lors D'exercices Modérés Continus Et Intermittents Intenses Chez Des Adolescents Vivant Avec Le Diabète De Type 1
Study type: INTERVENTIONAL
Overall status: RECRUITING
Phase: NA
Conditions: Type 1 Diabetes
Keywords: adolescents
type 1 diabetes
glycemic regulation
circadian rhythm
Lead sponsor: Lille University
Sponsor class: OTHER
First posted: 2025-01-31
Enrollment: 18
Sex: ALL
Minimum age (years): 10
Maximum age (years): 16
Standard ages: CHILD
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: CROSSOVER
Intervention model description: 4 randomized handovers performed (on different days with meal/snack)previous standardized:

* Continuous exercise on ergocycle in the morning
* Continuous exercise on ergocycle in the afternoon
* Intermittent exercise on ergocycle in the morning
* Intermittent exercice on ergocycle in the afternoon
Primary purpose: HEALTH_SERVICES_RESEARCH

Brief summary: Interventional research with minimal risks and constraints on the effects of circadian rhythm on glycemic regulation during intense moderate, continuous and intermittent exercise in adolescents living with type 1 diabetes

Detailed description: Single-center, randomized, controlled study in adolescents living with type 1 diabetes. This study aims to evaluate the effect of exercise timing (morning vs. afternoon) and exercise type (continuous vs. intermittent) on blood glucose levels during and after exercise, as well as to assess the effect of exercise timing (morning vs. afternoon) and type of exercise (continuous vs. intermittent) on blood glucose during and after exercise

Eligibility criteria: Inclusion Criteria:

* Children and adolescents aged 10 to 16;
* Living with type 1 diabetes for at least 1 year with HbA1c less than or equal to 12%;
* Socially insured ;
* Having given their written consent to participate in the research, as well as that of their legal guardians;
* Willing to comply with all research procedures and duration.

Exclusion Criteria:

* Clinically significant microvascular complications: nephropathy (estimated glomerular filtration rate less than 40 ml/min), neuropathy or severe proliferative retinopathy as assessed by the investigator;
* Recent acute macrovascular event (\< 3 months), e.g. acute coronary syndrome or cardiac surgery;
* Abnormal blood picture and/or anemia;
* Current pregnancy;
* Other serious medical condition likely to interfere with study participation or ability to complete exercise periods in the judgment of the investigator (e.g., orthopedic limitation);
* Inability to receive informed information;
* Inability to participate in the entire study;
* Lack of social security coverage;
* Refusal to sign consent form.

Primary outcomes:
measure: Comparison of glycemic variation between the 4 conditions
timeFrame: 1 year 10 months september 2026
Secondary outcomes:
Other outcomes:
Locations:
city: Loos
country: France
facility: Eurasport
state: Nord
Study officials:
References: