Clinical trial NCT03105128: A Study of the Efficacy and Safety of Risankizumab in Participants With Moderately to Severely Active Crohn's Disease
Official title: A Multicenter, Randomized, Double-Blind, Placebo Controlled Induction Study of the Efficacy and Safety of Risankizumab in Subjects With Moderately to Severely Active Crohn's Disease
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE3
Conditions: Crohn's Disease
Keywords: Crohn's Disease (CD)
Risankizumab
ABBV-066
BI 655066
Lead sponsor: AbbVie
Sponsor class: INDUSTRY
First posted: 2017-04-07
Enrollment: 931
Sex: ALL
Minimum age (years): 16
Maximum age (years): 80
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The purpose of this study is to evaluate the efficacy and safety of risankizumab versus placebo during induction therapy in participants with moderately to severely active Crohn's disease (CD).


Eligibility criteria: Inclusion Criteria:

* Male or female aged \>=18 to \<= 80 years, or minimum age of adult consent according to local regulations, at the Baseline Visit. Where locally permissible, participants 16 to \< 18 years of age who meet the definition of Tanner stage 5 for development at the Baseline Visit.
* Diagnosis of CD for at least 3 months prior to Baseline.
* Confirmed diagnosis of moderate to severe CD as assessed by stool frequency (SF), abdominal pain (AP) score, and Simple Endoscopic Score for Crohn's Disease (SES-CD).
* Demonstrated intolerance or inadequate response to conventional or to biologic therapy for CD.
* If female, participant must meet the contraception recommendations.

Exclusion Criteria:

* Participant with a current diagnosis of ulcerative colitis or indeterminate colitis.
* Participants with unstable doses of concomitant Crohn's disease therapy.
* Receipt of Crohn's disease approved biologic agents (infliximab, adalimumab, certolizumab, vedolizumab, natalizumab within 8 weeks prior to Baseline or ustekinumab within 12 weeks prior to Baseline), or any investigational biologic or other agent or procedure within 35 days or 5 half-lives prior to Baseline, whichever is longer.
* Prior exposure to p19 inhibitors (e.g., risankizumab).
* Complications of Crohn's disease.
* Having an ostomy or ileoanal pouch.
* Known active Coronavirus Disease 2019 (COVID-19) infection.

Primary outcomes:
measure: US Specific: Percentage of Participants With Crohn's Disease Activity Index (CDAI) Clinical Remission
timeFrame: Week 12
measure: US Specific: Percentage of Participants With Endoscopic Response
timeFrame: Week 12
measure: Global Outside of US: Percentage of Participants With Clinical Remission
timeFrame: Week 12
measure: Global Outside of US: Percentage of Participants With Endoscopic Response
timeFrame: Week 12
Secondary outcomes:
measure: US Specific: Percentage of Participants With Clinical Remission
timeFrame: Week 12
measure: US Specific: Percentage of Participants With Crohn's Disease Activity Index (CDAI) Clinical Response
timeFrame: Week 4
measure: US Specific: Percentage of Participants With Crohn's Disease Activity Index (CDAI) Clinical Response
timeFrame: Week 12
measure: US Specific: Change From Baseline of Functional Assessment of Chronic Illness Therapy (FACIT)-Fatigue
timeFrame: Week 12
measure: US Specific: Percentage of Participants With Crohn's Disease Activity Index (CDAI) Clinical Remission
timeFrame: Week 4
measure: US Specific: Percentage of Participants With CDAI Clinical Response and Endoscopic Response
timeFrame: Week 12
measure: US Specific: Percentage of Participants With Stool Frequency (SF) Remission
timeFrame: Week 12
measure: US Specific: Percentage of Participants With Abdominal Pain (AP) Remission
timeFrame: Week 12
measure: US Specific: Percentage of Participants With Endoscopic Remission
timeFrame: Week 12
measure: US Specific: Percentage of Participants With Enhanced Clinical Response
timeFrame: Week 4
measure: US Specific: Percentage of Participants With Ulcer-Free Endoscopy
timeFrame: Week 12
measure: US Specific: Percentage of Participants With Enhanced Clinical Response
timeFrame: Week 12
measure: US Specific: Percentage of Participants With Resolution of Extra-Intestinal Manifestations (EIMs), in Participants With EIMs at
timeFrame: Week 12
measure: US Specific: Percentage of Participants With CD-Related Hospitalization
timeFrame: Week 12
measure: US Specific: Percentage of Participants Without Draining Fistulas in Participants With Draining Fistulas at Baseline
timeFrame: Week 12
measure: Global Outside of US: Percentage of Participants With Crohn's Disease Activity Index (CDAI) Clinical Remission
timeFrame: Week 12
measure: Global Outside of US: Percentage of Participants With Crohn's Disease Activity Index (CDAI) Clinical Response
timeFrame: Week 4
measure: Global Outside of US: Percentage of Participants With Clinical Remission
timeFrame: Week 4
measure: Global Outside of US: Percentage of Participants With Crohn's Disease Activity Index (CDAI) Clinical Response
timeFrame: Week 12
measure: Global Outside of US: Change From Baseline of Functional Assessment of Chronic Illness Therapy (FACIT)-Fatigue
timeFrame: Week 12
measure: Global Outside of US: Change From Baseline in Inflammatory Bowel Disease Questionnaire (IBDQ) Total Score
timeFrame: Week 12
measure: Global Outside of US: Percentage of Participants With Enhanced Clinical Response and Endoscopic Response
timeFrame: Week 12
measure: Global Outside of US: Percentage of Participants With Endoscopic Remission
timeFrame: Week 12
measure: Global Outside of US: Percentage of Participants With Enhanced Clinical Response
timeFrame: Week 4
measure: Global Outside of US: Percentage of Participants With Ulcer-Free Endoscopy
timeFrame: Week 12
measure: Global Outside of US: Percentage of Participants With Enhanced Clinical Response
timeFrame: Week 12
measure: Global Outside of US: Percentage of Participants With Resolution of Extra-Intestinal Manifestations (EIMs), in Participants With EIMs at Baseline
timeFrame: Week 12
measure: Global Outside of US: Percentage of Participants With CD-Related Hospitalization
timeFrame: Week 12
measure: Global Outside of US: Percentage of Participants Without Draining Fistulas in Participants With Draining Fistulas at Baseline
timeFrame: Week 12
measure: Global Outside of US: Change From Baseline in Work Productivity and Impairment Questionnaire - Crohn's Disease (WPAI-CD) Overall Work Impairment
timeFrame: Week 12
measure: Global Outside of US: Change From Baseline in Short Form-36 (SF-36) Physical Component Summary (PCS) Score
timeFrame: Week 12
Other outcomes:
Locations:
city: Phoenix
country: United States
facility: Phoenix VA Health Care System /ID# 162267
state: Arizona
city: Scottsdale
country: United States
facility: HonorHealth Research Institute - Shea /ID# 161783
state: Arizona
city: Tempe
country: United States
facility: Digestive Disease Consultants, A Division of Arizona Digestive Health, P.C /ID# 211883
state: Arizona
city: Tucson
country: United States
facility: University of Arizona /ID# 158469
state: Arizona
city: Little Rock
country: United States
facility: Atria Clinical Research /ID# 164740
state: Arkansas
city: Huntington Beach
country: United States
facility: Newport Huntington Medica /ID# 213033
state: California
city: Los Alamitos
country: United States
facility: United Medical Doctors /ID# 207040
state: California
city: Los Angeles
country: United States
facility: TLC Clinical Research Inc /ID# 212503
state: California
city: Los Angeles
country: United States
facility: Gastrointestinal Biosciences Clinical Trials, LLC /ID# 162656
state: California
city: Murrieta
country: United States
facility: United Medical Doctors - Murrieta /ID# 158424
state: California
city: Riverside
country: United States
facility: Southern CA Research Ctr., Inc /ID# 167875
state: California
city: San Francisco
country: United States
facility: University of California, San Francisco /ID# 157143
state: California
city: West Hollywood
country: United States
facility: Cedars-Sinai Medical Center-West Hollywood /ID# 163842
state: California
city: Colorado Springs
country: United States
facility: Peak Gastroenterology Associates, PC /ID# 165834
state: Colorado
city: Lone Tree
country: United States
facility: Rocky Mountain Pediatric Gastroenterology /ID# 207169
state: Colorado
city: Danbury
country: United States
facility: Western Connecticut Medical Group /ID# 165849
state: Connecticut
city: Brandon
country: United States
facility: Seffner Premier Health Care, PA /ID# 162265
state: Florida
city: Clearwater
country: United States
facility: Clinical Research of West Florida, Inc /ID# 204859
state: Florida
city: Clearwater
country: United States
facility: Clinical Research of West Florida, Inc /ID# 207450
state: Florida
city: Clermont
country: United States
facility: South Lake Pain Institute, Inc /ID# 162825
state: Florida
city: Doral
country: United States
facility: Universal Axon Clinical Research /ID# 165432
state: Florida
city: Inverness
country: United States
facility: Nature Coast Clinical Research - Inverness /ID# 159414
state: Florida
city: Kissimmee
country: United States
facility: SIH Research Mumtaz, Inc /ID# 163082
state: Florida
city: Lighthouse Point
country: United States
facility: Alliance Medical Research /ID# 163840
state: Florida
city: Maitland
country: United States
facility: Cfagi Llc /Id# 201571
state: Florida
city: Miami
country: United States
facility: Vista Health Research, LLC /ID# 212664
state: Florida
city: Miami
country: United States
facility: ITB Research /ID# 161334
state: Florida
city: Miami
country: United States
facility: Coral Research Clinic /ID# 158549
state: Florida
city: Miami
country: United States
facility: South Florida Research Ph I-IV, Inc. /ID# 161836
state: Florida
city: Naples
country: United States
facility: Gastroenterology Group Naples /ID# 165206
state: Florida
city: New Port Richey
country: United States
facility: Advanced Research Institute, Inc /ID# 161959
state: Florida
city: Orlando
country: United States
facility: Endoscopic Research, Inc. /ID# 205901
state: Florida
city: Orlando
country: United States
facility: Omega Research Maitland, LLC /ID# 171081
state: Florida
city: Palmetto Bay
country: United States
facility: IMIC Inc. Medical Research /ID# 154943
state: Florida
city: Tampa
country: United States
facility: Clinical Research Trials of Florida, Inc. /ID# 201014
state: Florida
city: Macon
country: United States
facility: Gastroenterology Associates of Central Georgia, LLC /ID# 154857
state: Georgia
city: Chicago
country: United States
facility: Northwestern University Division of GI/Hepatology /ID# 158283
state: Illinois
city: Chicago
country: United States
facility: The University of Chicago Medical Center /ID# 157141
state: Illinois
city: Evanston
country: United States
facility: NorthShore University HealthSystem /ID# 158287
state: Illinois
city: Oak Lawn
country: United States
facility: Southwest Gastroenterology /ID# 165002
state: Illinois
city: Topeka
country: United States
facility: Cotton-O'Neil Clinical Res Ctr /ID# 154738
state: Kansas
city: Lexington
country: United States
facility: University of Kentucky Chandler Medical Center /ID# 157137
state: Kentucky
city: Louisville
country: United States
facility: University of Louisville /ID# 210521
state: Kentucky
city: Baton Rouge
country: United States
facility: Gastroenterology Associates LLC - Jefferson Hwy /ID# 161956
state: Louisiana
city: Houma
country: United States
facility: Houma Digestive Health Special /ID# 158286
state: Louisiana
city: New Orleans
country: United States
facility: Delricht Research /ID# 206542
state: Louisiana
city: New Orleans
country: United States
facility: Nola Research Works, LLC /ID# 161330
state: Louisiana
city: Shreveport
country: United States
facility: Louisana Research Center, LLC /ID# 162236
state: Louisiana
city: Chevy Chase
country: United States
facility: MGG Group Co, Inc.Chevy Chase Clinical Research /ID# 154839
state: Maryland
city: Columbia
country: United States
facility: Gastro Center of Maryland /ID# 165004
state: Maryland
city: Ann Arbor
country: United States
facility: University of Michigan Health Systems /ID# 157144
state: Michigan
city: Troy
country: United States
facility: Center for Digestive Health /ID# 154690
state: Michigan
city: Wyoming
country: United States
facility: Gastroenterology Associates of Western Michigan, PLC d.b.a. West Michigan Clinic /ID# 161328
state: Michigan
city: Rochester
country: United States
facility: Mayo Clinic - Rochester /ID# 163085
state: Minnesota
city: Jackson
country: United States
facility: Southern Therapy and Advanced Research (STAR) LLC /ID# 162388
state: Mississippi
city: Saint Louis
country: United States
facility: St. Louis University /ID# 161902
state: Missouri
city: Omaha
country: United States
facility: University of Nebraska Medical Center /ID# 210057
state: Nebraska
city: Las Vegas
country: United States
facility: Las Vegas Medical Research /ID# 160172
state: Nevada
city: Las Vegas
country: United States
facility: Revival Research Institute, Inc /ID# 210984
state: Nevada
city: Brooklyn
country: United States
facility: NY Scientific /ID# 158418
state: New York
city: Burnt Hills
country: United States
facility: Saratoga Schenectady Gastroenterology Associates - Burnt Hills /ID# 212036
state: New York
city: Fresh Meadows
country: United States
facility: Intercity Advanced Gastroentertology Center /ID# 213399
state: New York
city: Great Neck
country: United States
facility: Duplicate_Long Island Clinical Research /ID# 154836
state: New York
city: New Hyde Park
country: United States
facility: Digestive Disease Care /ID# 209619
state: New York
city: New Hyde Park
country: United States
facility: North Shore University Hospital /ID# 168736
state: New York
city: New York
country: United States
facility: NYU Langone Medical Center /ID# 160171
state: New York
city: New York
country: United States
facility: Columbia Univ Medical Center /ID# 161911
state: New York
city: New York
country: United States
facility: Lenox Hill Hospital /ID# 168465
state: New York
city: North Massapequa
country: United States
facility: DiGiovanna Institute for Medical Education & Research /ID# 171118
state: New York
city: Chapel Hill
country: United States
facility: Univ NC Chapel Hill /ID# 154840
state: North Carolina
city: Charlotte
country: United States
facility: Atrium Health Carolinas Medical Center /ID# 158481
state: North Carolina
city: Hickory
country: United States
facility: Clinical Trials America /ID# 158484
state: North Carolina
city: Kinston
country: United States
facility: Vidant Multispecialty Clinic - Kinston /ID# 161111
state: North Carolina
city: Raleigh
country: United States
facility: Wake Radiology UNC REX Healthcare - Raleigh Office /ID# 154880
state: North Carolina
city: Fargo
country: United States
facility: Plains Clinical Research Center, LLC /ID# 169715
state: North Dakota
city: Cincinnati
country: United States
facility: Tri-State Endoscopy /ID# 154933
state: Ohio
city: Cleveland
country: United States
facility: Cleveland Clinic Main Campus /ID# 208171
state: Ohio
city: Columbus
country: United States
facility: The Ohio State University /ID# 164709
state: Ohio
city: Columbus
country: United States
facility: Optimed Research, Ltd. /ID# 167901
state: Ohio
city: Dayton
country: United States
facility: Hometown Urgent Care and Resea /ID# 170453
state: Ohio
city: Mentor
country: United States
facility: Great Lakes Medical Research, LLC /ID# 201732
state: Ohio
city: Oklahoma City
country: United States
facility: Hightower Clinical /ID# 211938
state: Oklahoma
city: Oklahoma City
country: United States
facility: Digestive Disease Specialists /ID# 170774
state: Oklahoma
city: Tulsa
country: United States
facility: Adult Gastroenterology Associates - Gen 1 Research /ID# 206125
state: Oklahoma
city: Portland
country: United States
facility: Northwest Gastroenterology Clinic /ID# 158288
state: Oregon
city: Hershey
country: United States
facility: PennState Milton S.Hershey Med /ID# 154883
state: Pennsylvania
city: Pittsburgh
country: United States
facility: Children's Hospital of Pittsburgh of UPMC /ID# 210920
state: Pennsylvania
city: Wyomissing
country: United States
facility: Digestive Disease Associates, LTD /ID# 208847
state: Pennsylvania
city: Charleston
country: United States
facility: Medical University of South Carolina /ID# 212579
state: South Carolina
city: Greenville
country: United States
facility: Gastroenterology Associates, P.A. of Greenville /ID# 154911
state: South Carolina
city: Rapid City
country: United States
facility: Rapid City Medical Center - GI Research /ID# 163841
state: South Dakota
city: Germantown
country: United States
facility: Gastro One /ID# 154742
state: Tennessee
city: Johnson City
country: United States
facility: East Tennessee Research Institute /ID# 168737
state: Tennessee
city: Memphis
country: United States
facility: Duplicate_Clinical Neuroscience Solutions /ID# 164181
state: Tennessee
city: Nashville
country: United States
facility: Vanderbilt University Medical Center /ID# 157138
state: Tennessee
city: Arlington
country: United States
facility: TX Clinical Research Institute /ID# 159410
state: Texas
city: Baytown
country: United States
facility: Inquest Clinical Research /ID# 165695
state: Texas
city: Cedar Park
country: United States
facility: Texas Digestive Disease Consultants /ID# 209596
state: Texas
city: Cedar Park
country: United States
facility: Texas Digestive Disease Consultants /ID# 209785
state: Texas
city: Dallas
country: United States
facility: Baylor Scott & White Center for Inflammatory Bowel Diseases /ID# 201848
state: Texas
city: Garland
country: United States
facility: DHAT Research Institute /ID# 158217
state: Texas
city: Houston
country: United States
facility: Vilo Research Group Inc /ID# 206130
state: Texas
city: Houston
country: United States
facility: CliniCore International, LLC /ID# 158209
state: Texas
city: Houston
country: United States
facility: Baylor College of Medicine - Baylor Medical Center /ID# 158212
state: Texas
city: Houston
country: United States
facility: Precision Research Institute, LLC /ID# 200503
state: Texas
city: Houston
country: United States
facility: Centex Studies, Inc. - Houston /ID# 200720
state: Texas
city: San Antonio
country: United States
facility: Clinical Associates in Research Therapeutics of America, LLC /ID# 161336
state: Texas
city: San Antonio
country: United States
facility: Southern Star Research Institute, LLC /ID# 168770
state: Texas
city: Tyler
country: United States
facility: Tyler Research Institute, LLC /ID# 166796
state: Texas
city: Victoria
country: United States
facility: Gastro Health & Nutrition - Victoria /ID# 164296
state: Texas
city: Bountiful
country: United States
facility: HP Clinical Research /ID# 162998
state: Utah
city: Ogden
country: United States
facility: Advanced Research Institute /ID# 154914
state: Utah
city: West Jordan
country: United States
facility: Velocity Clinical Research - Salt Lake City /ID# 161781
state: Utah
city: Richmond
country: United States
facility: McGuire DV AMC /ID# 159990
state: Virginia
city: Bellevue
country: United States
facility: Washington Gastroenterology Associates /ID# 162120
state: Washington
city: Seattle
country: United States
facility: Virginia Mason - Seattle Orthapedics /ID# 155545
state: Washington
city: Morgantown
country: United States
facility: WVU Medicine /ID# 167940
state: West Virginia
city: Rosario
country: Argentina
facility: Duplicate_HOSPITAL CENTENARIO /ID# 170883
state: Santa Fe
city: Cordoba
country: Argentina
facility: Hospital Privado Univesitario /ID# 161988
city: South Brisbane
country: Australia
facility: Duplicate_Mater Hospital /ID# 167990
state: Queensland
city: Southport
country: Australia
facility: Griffith University /ID# 212627
state: Queensland
city: Elizabeth Vale
country: Australia
facility: Lyell McEwin Hospital /ID# 211363
state: South Australia
city: Camberwell
country: Australia
facility: Emeritus Research /ID# 213511
state: Victoria
city: Footscray
country: Australia
facility: Footscray Hospital /ID# 211361
state: Victoria
city: Sankt Poelten
country: Austria
facility: Universitaetsklinikum St. Poelten /ID# 166425
state: Niederoesterreich
city: Graz
country: Austria
facility: Medizinische Universitaet Graz /ID# 158137
state: Steiermark
city: Vienna
country: Austria
facility: Krankenhaus der Barmherzigen Brueder Wien /ID# 212059
state: Wien
city: Vienna
country: Austria
facility: Duplicate_Medical University of Vienna /ID# 158138
state: Wien
city: Gomel
country: Belarus
facility: Gomel Regional Clinical Hospital /ID# 159498
city: Grodno
country: Belarus
facility: Grodno city clinical hospital #2 /ID# 159499
city: Витебск
country: Belarus
facility: Vitebsk Regional Advanced Clin /ID# 159497
city: Brussels
country: Belgium
facility: ULB Hospital Erasme /ID# 157397
state: Bruxelles-Capitale
city: Woluwe-Saint-Lambert
country: Belgium
facility: UCL Saint-Luc /ID# 157395
state: Bruxelles-Capitale
city: Godinne
country: Belgium
facility: CHU UCL Namur - site Godinne /ID# 157401
state: Namur
city: Gent
country: Belgium
facility: UZ Gent /ID# 157394
state: Oost-Vlaanderen
city: Leuven
country: Belgium
facility: Universitair Ziekenhuis Leuven /ID# 157396
state: Vlaams-Brabant
city: Bonheiden
country: Belgium
facility: Imelda Ziekenhuis /ID# 157392
city: Liege
country: Belgium
facility: CHU de Liege /ID# 157398
city: Liege
country: Belgium
facility: Groupe Sante CHC - Clinique du MontLegia /ID# 157393
city: Roeselare
country: Belgium
facility: AZ-Delta /ID# 157391
city: Banja Luka
country: Bosnia and Herzegovina
facility: University Clinical Centre of the Republic of Srpska /ID# 157717
state: Republika Srpska
city: Banja Luka
country: Bosnia and Herzegovina
facility: University Clinical Centre of the Republic of Srpska /ID# 164512
state: Republika Srpska
city: Sarajevo
country: Bosnia and Herzegovina
facility: Clinical Center University of Sarajevo /ID# 165134
city: Goiânia
country: Brazil
facility: Instituto Goiano de Gastroenterologia e Endoscopia Digestiva /ID# 157672
state: Goias
city: Curitiba
country: Brazil
facility: Hospital Nossa Senhora das Graças /ID# 157646
state: Parana
city: Porto Alegre
country: Brazil
facility: Hospital de Clinicas de Porto Alegre /ID# 157653
state: Rio Grande Do Sul
city: Botucatu
country: Brazil
facility: Upeclin Fmb - Unesp /Id# 157688
state: Sao Paulo
city: Ribeirão Preto
country: Brazil
facility: Hospital das Clinicas da Faculdade de Medicina de Ribeirao Preto - USP /ID# 157649
state: Sao Paulo
city: Santo André
country: Brazil
facility: Faculdade de Medicina do ABC /ID# 159672
state: Sao Paulo
city: Sao Jose Do Rio Preto
country: Brazil
facility: Kaiser Clinica e Hospital Dia /ID# 157656
state: Sao Paulo
city: Pleven
country: Bulgaria
facility: UMHAT Dr Georgi Stranski EAD /ID# 203977
city: Plovdiv
country: Bulgaria
facility: University Multiprofile Hospit /ID# 158644
city: Sofia
country: Bulgaria
facility: Second Multiprofile Hospital f /ID# 158646
city: Sofia
country: Bulgaria
facility: Duplicate_Tokuda Hospital Sofia /ID# 158645
city: Sofia
country: Bulgaria
facility: UMHAT Sveti Ivan Rilski /ID# 204714
city: Sofia
country: Bulgaria
facility: UMHAT Tsaritsa Joanna - ISUL /ID# 211240
city: Stara Zagora
country: Bulgaria
facility: MHAT Trakia /ID# 201672
city: Varna
country: Bulgaria
facility: University Multiprofile Hospit /ID# 167575
city: Calgary
country: Canada
facility: University of Calgary - Heritage Medical Research Clinic /ID# 157152
state: Alberta
city: Edmonton
country: Canada
facility: Allen Whey Khye Lim Professional Corporation /ID# 169761
state: Alberta
city: Edmonton
country: Canada
facility: University of Alberta - Zeidler Ledcor Centre /ID# 157098
state: Alberta
city: Edmonton
country: Canada
facility: Covenant Health /ID# 161617
state: Alberta
city: New Westminster
country: Canada
facility: Fraser Clinical Trials Inc /ID# 159053
state: British Columbia
city: Vancouver
country: Canada
facility: GIRI Gastrointestinal Research Institute /ID# 157095
state: British Columbia
city: Victoria
country: Canada
facility: Percuro Clinical Research, Ltd /ID# 161616
state: British Columbia
city: Halifax
country: Canada
facility: QEII - Health Sciences Centre /ID# 157087
state: Nova Scotia
city: Halifax
country: Canada
facility: IWK Health Center /ID# 165900
state: Nova Scotia
city: London
country: Canada
facility: London Health Sciences Center /ID# 157160
state: Ontario
city: North Bay
country: Canada
facility: Scott Shulman Medicine Professional Corporation /ID# 165903
state: Ontario
city: Sudbury
country: Canada
facility: Medicor Research Inc /ID# 157149
state: Ontario
city: Toronto
country: Canada
facility: Mount Sinai Hospital /ID# 169762
state: Ontario
city: Vaughan
country: Canada
facility: Toronto Digestive Disease Asso /ID# 157157
state: Ontario
city: Greenfield Park
country: Canada
facility: CISSS de la Monteregie /ID# 161615
state: Quebec
city: Levis
country: Canada
facility: CHAU- Hotel-Dieu de Levis /ID# 214375
state: Quebec
city: Montreal
country: Canada
facility: CIUSSS de l'est de l'Ile-de-Montreal - Hopital Maisonneuve-Rosemont /ID# 159054
state: Quebec
city: Montreal
country: Canada
facility: CHUM - Centre hospitalier de l'Universite de Montréal /ID# 167066
state: Quebec
city: Montreal
country: Canada
facility: Montreal General Hospital - McGill University Health Center /ID# 157084
state: Quebec
city: Santiago
country: Chile
facility: Complejo Asistencial Dr. Sotero del Rio /ID# 169382
state: Region Metropolitana De Santiago
city: Viña del Mar
country: Chile
facility: Centro de Investigaciones Clínicas Viña del Mar /ID# 203589
state: Valparaíso
city: Concepción
country: Chile
facility: Hospital Guillermo Grant Benavente de Concepción /ID# 210759
city: Talcahuano
country: Chile
facility: Hospital Las Higueras /ID# 167090
city: Guangzhou
country: China
facility: Guangdong Provincial People's Hospital /ID# 212948
state: Guangdong
city: Guangzhou
country: China
facility: The Sixth Affiliated Hosp Sun /ID# 210785
state: Guangdong
city: Shijiazhuang
country: China
facility: The Second Hospital of Hebei Medical University /ID# 212740
state: Hebei
city: Wuhan
country: China
facility: Tongji Hospital Tongji Medical College Huazhong University of Science and Techno /ID# 210856
state: Hubei
city: Wuhan
country: China
facility: Union Hospital affiliated to Tongji Medical College of Huazhong University of Sc /ID# 211038
state: Hubei
city: Wuhan
country: China
facility: Renmin Hospital of Wuhan University /ID# 214873
state: Hubei
city: Nanchang
country: China
facility: The First Affiliated Hospital of Nanchang University /ID# 211034
state: Jiangxi
city: Shanghai
country: China
facility: Ruijin Hospital, Shanghai Jiaotong University School of Medicine /ID# 210841
state: Shanghai
city: Shanghai
country: China
facility: Renji Hospital, Shanghai Jiaotong University School of Medicine /ID# 210707
state: Shanghai
city: Hangzhou
country: China
facility: The second Affiliated hospital of Zhejiang University school of Medicine /ID# 210725
state: Zhejiang
city: Hangzhou
country: China
facility: Sir Run Run Shaw Hospital Zhejiang University School of Medicine /ID# 210624
state: Zhejiang
city: Jinhua
country: China
facility: Jinhua Municipal Central Hospital /ID# 215626
state: Zhejiang
city: Changsha
country: China
facility: The Second Hospital Central South University /ID# 211696
city: Chengdu
country: China
facility: West China Hospital, Sichuan University /ID# 210889
city: Pudong New District
country: China
facility: Shanghai East Hospital /ID# 212683
city: Tianjin
country: China
facility: Tianjin Medical University General Hospital /ID# 210927
city: Medellin
country: Colombia
facility: Instituto de Coloproctologia /ID# 158741
state: Antioquia
city: Medellín
country: Colombia
facility: Hospital Pablo Tobon Uribe /ID# 158735
state: Antioquia
city: Bogota
country: Colombia
facility: Hospital Univ San Ignacio /ID# 158733
state: Cundinamarca
city: Medellin
country: Colombia
facility: Hospital Universitario San Vic /ID# 171487
city: Zagreb
country: Croatia
facility: Duplicate_Klinicka bolnica Dubrava Zagreb /ID# 157565
state: Grad Zagreb
city: Zagreb
country: Croatia
facility: Klinicki bolnicki centar Sestre milosrdnice /ID# 157721
state: Grad Zagreb
city: Zagreb
country: Croatia
facility: Klinicki bolnicki centar Zagreb /ID# 157566
state: Grad Zagreb
city: Osijek
country: Croatia
facility: UHC Osijek /ID# 157564
state: Osjecko-baranjska Zupanija
city: Split
country: Croatia
facility: Klinicki bolnicki centar Split /ID# 157567
state: Splitsko-dalmatinska Zupanija
city: Prague 4
country: Czechia
facility: Duplicate_Institut klinicke a experimentalni mediciny (IKEM) /ID# 165463
state: Praha 4
city: Hradec Kralove
country: Czechia
facility: Hepato-Gastroenterologie HK, s.r.o. /ID# 163134
city: Olomouc
country: Czechia
facility: CTCenter MaVe s.r.o. /ID# 163149
city: Pardubice
country: Czechia
facility: Nemocnice Pardubickeho kraje, a.s. /ID# 163182
city: Praha
country: Czechia
facility: Nemocnice Milosrdnych sester sv. Karla Boromejskeho v Praze /ID# 211305
city: Praha
country: Czechia
facility: Axon Clinical, s.r.o. /ID# 163176
city: Praha
country: Czechia
facility: Thomayerova nemocnice /ID# 162940
city: Praha
country: Czechia
facility: ResTrial s.r.o. /ID# 211075
city: Praha
country: Czechia
facility: NH Hospital a.s. /ID# 211076
city: Tallinn
country: Estonia
facility: East Tallinn Central Hospital /ID# 157076
state: Harjumaa
city: Tallinn
country: Estonia
facility: West Tallinn Central Hospital /ID# 157077
city: Tallinn
country: Estonia
facility: North Estonia Medical Centre /ID# 163507
city: Freiburg
country: Germany
facility: Universitaetsklinikum Freiburg /ID# 162019
state: Baden-Wuerttemberg
city: Heidelberg
country: Germany
facility: Praxis fuer Gastroenterologie /ID# 166145
state: Baden-Wuerttemberg
city: Mannheim
country: Germany
facility: Universitatsklinikum Mannheim /ID# 162020
state: Baden-Wuerttemberg
city: Tübingen
country: Germany
facility: Universitaetsklinikum Tuebingen /ID# 159324
state: Baden-Wuerttemberg
city: Ulm
country: Germany
facility: Universitaetsklinikum Ulm /ID# 164986
state: Baden-Wuerttemberg
city: Erlangen
country: Germany
facility: Universitaetsklinikum Erlangen /ID# 159315
state: Bayern
city: Frankfurt am Main
country: Germany
facility: Universitaetsklinikum Frankfurt /ID# 212978
state: Hessen
city: Cologne
country: Germany
facility: Evangelisches Krankenhaus Kalk /ID# 212725
state: Nordrhein-Westfalen
city: Grevenbroich
country: Germany
facility: Praxiszentrum fuer Gastroenterologie /ID# 211964
state: Nordrhein-Westfalen
city: Köln
country: Germany
facility: Universitaetsklinikum Koeln /ID# 164985
state: Nordrhein-Westfalen
city: Muenster
country: Germany
facility: Universitaetsklinikum Muenster /ID# 159316
state: Nordrhein-Westfalen
city: Saarbrücken
country: Germany
facility: Zentrum für Gastroenterologie Saar MVZ GmbH /ID# 210529
state: Saarland
city: Kiel
country: Germany
facility: Universitaetsklinikum Schleswig-Holstein Campus Kiel /ID# 159321
state: Schleswig-Holstein
city: Jena
country: Germany
facility: Universitaetsklinikum Jena /ID# 159323
state: Thueringen
city: Berlin-Zehlendorf
country: Germany
facility: Krankenhaus Waldfriede /ID# 212728
city: Berlin
country: Germany
facility: Charite Universitaetsmedizin Berlin - Campus Mitte /ID# 212219
city: Berlin
country: Germany
facility: Charite Universitaetsmedizin Berlin - Campus Mitte /ID# 212893
city: Berlin
country: Germany
facility: Gastroenterologische Spezialpraxis am Wittenbergplatz /ID# 211972
city: Berlin
country: Germany
facility: MVZ fuer Gastroenterlogie am Bayerischen Platz /ID# 159322
city: Berlin
country: Germany
facility: DRK Kliniken Berlin Westend /ID# 166146
city: Braunschweig
country: Germany
facility: Stadtisches Klinikum Braunschweig /ID# 163666
city: Dachau
country: Germany
facility: Medizinisches Versorgunszentrum Dachau /ID# 211557
city: Frankfurt am Main
country: Germany
facility: Agaplesion Markus Krankenhaus /ID# 159317
city: Hamburg
country: Germany
facility: Asklepios Westklinikum Hamburg /ID# 159319
city: Hannover
country: Germany
facility: Medizinische Hochschule Hannover /ID# 162021
city: Leipzig
country: Germany
facility: EUGASTRO GmbH /ID# 212076
city: Lueneburg
country: Germany
facility: Klinikum Lueneburg /ID# 163664
city: Magdeburg
country: Germany
facility: Universitaetsklinikum Magdeburg /ID# 211847
city: Minden
country: Germany
facility: Gastroenterologische Gemeinschaftspraxis Minden /ID# 162018
city: Regensburg
country: Germany
facility: Universitaetsklinikum Regensburg /ID# 163665
city: Wiesbaden
country: Germany
facility: Duplicate_Gastro-Praxis Wiesbaden /ID# 159318
city: Athens
country: Greece
facility: General Hospital of Chest Diseases of Athens SOTIRIA /ID# 171077
state: Attiki
city: Piraeus
country: Greece
facility: Tzaneio general hospital of Piraeus /ID# 206445
state: Attiki
city: Heraklion
country: Greece
facility: University General Hospital of Heraklion PA.G.N.I /ID# 157427
state: Kriti
city: Athens
country: Greece
facility: General Hospital of Athens Evaggelismos and Ophthalmiatrio of Athens Polyclinic /ID# 157428
city: Ioannina
country: Greece
facility: University General Hospital of Ioannina /ID# 157425
city: Pireaus
country: Greece
facility: General Hospital of Nikaia-Piraeus "Agios Panteleimon"- general hospital dytikis /ID# 157429
city: Thessaloniki
country: Greece
facility: Theageneio Anticancer Hospital /ID# 163921
city: Hong Kong
country: Hong Kong
facility: Queen Mary Hospital /ID# 163902
city: Tuen Mun
country: Hong Kong
facility: Tuen Mun Hospital /ID# 163901
city: Beaumont
country: Ireland
facility: Beaumont Hospital /ID# 157515
state: Dublin
city: Elm Park
country: Ireland
facility: St Vincent's University Hospital /ID# 157512
state: Dublin
city: Galway
country: Ireland
facility: University Hospital Galway /ID# 157513
city: Be'er Sheva
country: Israel
facility: Soroka University Medical Center /ID# 157798
state: HaDarom
city: Ramat Gan
country: Israel
facility: Sheba Medical Center /ID# 157797
state: Tel-Aviv
city: Ramat Gan
country: Israel
facility: Sheba Medical Center /ID# 171074
state: Tel-Aviv
city: Tel Aviv-Yafo
country: Israel
facility: Tel Aviv Sourasky Medical Center /ID# 157796
state: Tel-Aviv
city: Haifa
country: Israel
facility: Duplicate_Rambam Medical Center /ID# 171072
city: Holon
country: Israel
facility: The Edith Wolfson Medical Center /ID# 217329
city: Jerusalem
country: Israel
facility: Shaare Zedek Medical Center /ID# 163540
city: Jerusalem
country: Israel
facility: Shaare Zedek Medical Center /ID# 171073
city: Jerusalem
country: Israel
facility: Hadassah Medical Center-Hebrew University /ID# 165913
city: Torrette
country: Italy
facility: Duplicate_AOU Ospendali Riuniti di Ancona /ID# 162427
state: Ancona
city: Catanzaro
country: Italy
facility: University of Catanzaro /ID# 212012
state: Calabria
city: Modena
country: Italy
facility: Duplicate_Azienda Ospedaliero-Universitaria Policlinico di Modena /ID# 212019
state: Emilia-Romagna
city: Rome
country: Italy
facility: Policlinico Universitario Campus Bio-Medico /ID# 162429
state: Lazio
city: Rome
country: Italy
facility: Azienda Ospedaliera San Camillo Forlanini /ID# 155636
state: Lazio
city: Rome
country: Italy
facility: Azienda Ospedaliero-Universitaria Policlinico Umberto I /ID# 166911
state: Lazio
city: Rozzano
country: Italy
facility: Istituto Clinico Humanitas /ID# 155634
state: Milano
city: Rome
country: Italy
facility: Fondazione PTV Policlinico Tor Vergata /ID# 158021
state: Roma
city: Rome
country: Italy
facility: Presidio Columbus-Fondazione Policlinico Universitario Agostino Gemelli IRCCS-Un /ID# 155632
state: Roma
city: Florence
country: Italy
facility: Duplicate_Azienda Ospedaliera Univ. Meyer /ID# 168051
state: Toscana
city: Negrar
country: Italy
facility: IRCCS Ospedale Sacro Cuore Don Calabria /ID# 161305
state: Verona
city: Bologna
country: Italy
facility: A.O.U. di Bologna Policlinico S.Orsola-Malpighi /ID# 155635
city: Catania
country: Italy
facility: A.O. Per L'Emergenza Cannizzaro /ID# 161306
city: Genova
country: Italy
facility: Ospedale Policlinico San Martino /ID# 162430
city: Milano
country: Italy
facility: ASST Fatebenefratelli Sacco-Ospedale Sacco /ID# 155631
city: Milan
country: Italy
facility: Fondazione IRCCS Ca Granda Ospedale Maggiore Policlinico /ID# 155633
city: Palermo
country: Italy
facility: A.O. Ospedali Riuniti Villa Sofia - Cervello /ID# 155637
city: Pavia
country: Italy
facility: Duplicate_Fondazione IRCCS Policlinico San Matteo /ID# 212029
city: Nagakute-shi
country: Japan
facility: Aichi Medical University Hospital /ID# 160159
state: Aichi
city: Nagoya shi
country: Japan
facility: Nagoya City University Hospital /ID# 160162
state: Aichi
city: Nagoya-shi
country: Japan
facility: Daido Clinic /ID# 211477
state: Aichi
city: Nagoyashi
country: Japan
facility: Nagoya University Hospital /ID# 160150
state: Aichi
city: Toyoake-shi
country: Japan
facility: Fujita Health University Hospital /ID# 163214
state: Aichi
city: Abiko-shi
country: Japan
facility: Tokatsu Tsujinaka Hospital /ID# 163362
state: Chiba
city: Chiba-shi
country: Japan
facility: Chiba University Hospital /ID# 217532
state: Chiba
city: Kashiwa-shi
country: Japan
facility: Tsujinaka Hospital Kashiwanoha /ID# 213847
state: Chiba
city: Kashiwa-shi
country: Japan
facility: The Jikei University Kashiwa Hospital /ID# 200007
state: Chiba
city: Sakura-shi
country: Japan
facility: Toho University Sakura Medical Center /ID# 160161
state: Chiba
city: Fukuoka-shi
country: Japan
facility: Fukuoka University Hospital /ID# 217792
state: Fukuoka
city: Kurume-shi
country: Japan
facility: Kurume University Hospital /ID# 160138
state: Fukuoka
city: Fukuyama-shi
country: Japan
facility: NHO Fukuyama Medical Center /ID# 163578
state: Hiroshima
city: Hiroshima-shi
country: Japan
facility: Hiroshima University Hospital /ID# 160139
state: Hiroshima
city: Midorigaokahiga-shi
country: Japan
facility: Asahikawa Medical University Hospital /ID# 162844
state: Hokkaido
city: Sapporo-shi
country: Japan
facility: Sapporo Tokushukai Hospital /ID# 213493
state: Hokkaido
city: Sapporo-shi
country: Japan
facility: Hokkaido P.W.F.A.C. Sapporo-Kosei General Hospital /ID# 160158
state: Hokkaido
city: Sapporo-shi
country: Japan
facility: Sapporo Medical University Hospital /ID# 163028
state: Hokkaido
city: Nishinomiya-shi
country: Japan
facility: Nishinomiya Munic Central Hospital /ID# 210104
state: Hyogo
city: Nishinomiya-shi
country: Japan
facility: Hyogo College of Medicine College Hospital /Id# 160164
state: Hyogo
city: Higashi Ibaraki-gun
country: Japan
facility: National Hospital Organization Mito Medical Center /ID# 160154
state: Ibaraki
city: Kanazawa-shi
country: Japan
facility: Kanazawa University Hospital /ID# 201766
state: Ishikawa
city: Kamakura-shi
country: Japan
facility: Gokeikai Ofuna Chuo Hospital /ID# 171070
state: Kanagawa
city: Sagamihara-shi
country: Japan
facility: Kitasato University Hospital /ID# 171071
state: Kanagawa
city: Yokohama shi
country: Japan
facility: Yokohama City University Medical Center /ID# 163906
state: Kanagawa
city: Yokohama-shi
country: Japan
facility: Yokohama Municipal Citizen's Hospital /ID# 204126
state: Kanagawa
city: Tsu-shi
country: Japan
facility: Mie University Hospital /ID# 203639
state: Mie
city: Yokkaichi-shi
country: Japan
facility: Yokkaichi Hazu Medical Center /ID# 163741
state: Mie
city: Sendai-shi
country: Japan
facility: Tohoku University Hospital /ID# 162843
state: Miyagi
city: Sendai-shi
country: Japan
facility: Duplicate_Tohoku Rosai Hospital /ID# 163189
state: Miyagi
city: Osaka-shi
country: Japan
facility: Osaka City University Hospital /ID# 160146
state: Osaka
city: Kawagoe-shi
country: Japan
facility: Saitama Medical Center /ID# 160155
state: Saitama
city: Saitama-shi
country: Japan
facility: Tokitokai Tokito clinic /ID# 160145
state: Saitama
city: Otsu-shi
country: Japan
facility: Shiga University of Medical Science Hospital /ID# 164022
state: Shiga
city: Hamamatsu-shi
country: Japan
facility: Hamamatsu University Hospital /ID# 205689
state: Shizuoka
city: Sunto-gun
country: Japan
facility: NHO Shizuoka Medical Center /ID# 163029
state: Shizuoka
city: Bunkyo-ku
country: Japan
facility: Tokyo Medical And Dental University, Medical Hospital /ID# 160157
state: Tokyo
city: Hachioji-shi
country: Japan
facility: Duplicate_Tokai University Hachioji Hospital /ID# 160160
state: Tokyo
city: Minato-ku
country: Japan
facility: The Jikei University Hospital /ID# 163190
state: Tokyo
city: Minato-ku
country: Japan
facility: Duplicate_Kitasato University Kitasato Institute Hospital /ID# 160144
state: Tokyo
city: Mitaka-shi
country: Japan
facility: Kyorin University Hospital /ID# 160149
state: Tokyo
city: Shinjuku-ku
country: Japan
facility: Tokyo Women's Medical University Hospital /ID# 205973
state: Tokyo
city: Wakayama-shi
country: Japan
facility: Wakayama Medical University Hospital /ID# 200183
state: Wakayama
city: Yamagata-shi
country: Japan
facility: Yamagata University Hospital /ID# 200154
state: Yamagata
city: Kofu-shi
country: Japan
facility: Yamanashi Prefectural Central Hospital /ID# 160156
state: Yamanashi
city: Guri
country: Korea, Republic of
facility: Hanyang University Guri Hospital /ID# 158673
state: Gyeonggido
city: Seongnam-si
country: Korea, Republic of
facility: Duplicate_CHA bundang medical center CHA University /ID# 158672
state: Gyeonggido
city: Suwon
country: Korea, Republic of
facility: Duplicate_The Catholic University of Korea, ST. Vincent's Hospital /ID# 158681
state: Gyeonggido
city: Seoul
country: Korea, Republic of
facility: Kangbuk Samsung Hospital /ID# 158676
state: Seoul Teugbyeolsi
city: Seoul
country: Korea, Republic of
facility: Severance Hospital /ID# 158671
state: Seoul Teugbyeolsi
city: Busan
country: Korea, Republic of
facility: Dong-A University Hospital /ID# 158675
city: Busan
country: Korea, Republic of
facility: Pusan National University Hospital /ID# 158677
city: Daegu
country: Korea, Republic of
facility: Yeungnam University Medical Center /ID# 158680
city: Daejeon
country: Korea, Republic of
facility: The Catholic University of Korea, Daejeon St.Mary's Hospital /ID# 213552
city: Seoul
country: Korea, Republic of
facility: Asan Medical Center /ID# 158678
city: Seoul
country: Korea, Republic of
facility: Samsung Medical Center /ID# 158674
city: Riga
country: Latvia
facility: Pauls Stradins Clinical University Hospital /ID# 159614
city: Riga
country: Latvia
facility: Digestive Disease Center Gastro /ID# 163105
city: Riga
country: Latvia
facility: Riga East Clinical University Hospital /ID# 159613
city: Kaunas
country: Lithuania
facility: Duplicate_Hospital of lithuanian university of Health Science Kauno Klinikos /ID# 162582
city: Vilnius
country: Lithuania
facility: Duplicate_Vilnius University Hospital /ID# 162507
city: Division Pantai Barat Utara
country: Malaysia
facility: Queen Elizabeth Hospital /ID# 160654
state: Sabah
city: Kuala Lumpur
country: Malaysia
facility: Universiti Kebangsaan Malaysia (UKM) Medical Centre /ID# 163654
state: Selangor
city: Kelantan
country: Malaysia
facility: Universiti Sains Malaysia /ID# 160656
city: Zapopan
country: Mexico
facility: Investigacion Biomedica para el Desarrollo de Farmacos, S.A. de C.V. /ID# 167648
state: Jalisco
city: Cuernavaca
country: Mexico
facility: JM Research SC /ID# 161733
state: Morelos
city: Merida
country: Mexico
facility: Unidad de Atencion Medica e Investigacion en Salud /ID# 163624
state: Yucatan
city: Del. Benito Juárez
country: Mexico
facility: Health Pharma Professional Research S.A de C.V /ID# 161734
city: Amsterdam
country: Netherlands
facility: Academisch Medisch Centrum /ID# 157950
city: Tilburg
country: Netherlands
facility: Elisabeth Tweesteden Ziekenhuis /ID# 163631
city: Christchurch
country: New Zealand
facility: Christchurch Hospital /ID# 163074
state: Canterbury
city: Dunedin
country: New Zealand
facility: Dunedin Hospital /ID# 167989
state: Otago
city: Newtown Wellington
country: New Zealand
facility: Wellington Regional Hospital /ID# 167987
state: Wellington
city: Nordbyhagen
country: Norway
facility: Akershus universitetssykehus /ID# 169378
state: Akershus
city: Gjettum
country: Norway
facility: Vestre viken - Baerum Sykehus /ID# 157886
city: Levanger
country: Norway
facility: Sykehuset Levanger Helse NT /ID# 157885
city: Ålesund
country: Norway
facility: Helse More og Romsdal HF, Alesund sjukehus /ID# 212811
city: Wroclaw
country: Poland
facility: Planetmed Sp. z o.o. /ID# 202798
state: Dolnoslaskie
city: Torun
country: Poland
facility: Gastromed /Id# 212099
state: Kujawsko-pomorskie
city: Lodz
country: Poland
facility: Uniwersytecki Szpital Kliniczny nr 1 im. Norberta Barlickiego w Lodzi /ID# 212297
state: Lodzkie
city: Lublin
country: Poland
facility: 1 Wojskowy Szpital Kliniczny Z Poliklinika /Id# 209985
state: Lubelskie
city: Lublin
country: Poland
facility: Samodzielny Publiczny Szpital Kliniczny Nr 4 w Lublinie /ID# 209981
state: Lubelskie
city: Warszawa
country: Poland
facility: Centrum Zdrowia MDM /ID# 160794
state: Mazowieckie
city: Warszawa
country: Poland
facility: Centralny Szpital Kliniczny MSWiA w Warszawie /ID# 160797
state: Mazowieckie
city: Warszawa
country: Poland
facility: Instytut Pomnik - Centrum Zdrowia Dziecka /ID# 213579
state: Mazowieckie
city: Rzeszów
country: Poland
facility: Centrum Medyczne Medyk /ID# 212889
state: Podkarpackie
city: Chojnice
country: Poland
facility: Centrum Medyczne LukaMed Joanna Luka-Wendrowska /ID# 212081
state: Pomorskie
city: Tychy
country: Poland
facility: H-T. Centrum Medyczne - Endoterapia /ID# 212459
state: Slaskie
city: Olsztyn
country: Poland
facility: Wojewodzki Szpital Specjalistyczny /ID# 212402
state: Warminsko-mazurskie
city: Poznan
country: Poland
facility: Duplicate_SOLUMED Sp. z o.o., Sp.k. /ID# 160793
city: Warsaw
country: Poland
facility: Duplicate_Niepubliczny Zakład Opieki Zdrowotnej VIVAMED Jadwiga Miecz /ID# 205160
city: Wroclaw
country: Poland
facility: Uniwersytecki Szpital Kliniczny im. Jana Mikulicza-Radeckiego we Wroclaw /ID# 212602
city: Guimaraes
country: Portugal
facility: Hospital da Senhora da Oliveira Guimaraes, EPE /ID# 160739
state: Braga
city: Portimão
country: Portugal
facility: Centro Hospitalar Universitário do Algarve, EPE - Hospital de Portimão /ID# 167750
state: Faro
city: Santa Maria Da Feira
country: Portugal
facility: Centro Hospitalar de Entre Douro e Vouga /ID# 160674
state: Porto
city: Almada
country: Portugal
facility: Hospital Garcia de Orta, EPE /ID# 160747
city: Faro
country: Portugal
facility: Centro Hospitalar Universitário do Algarve, EPE - Hospital Faro /ID# 160715
city: Lisboa
country: Portugal
facility: Centro Hospitalar Universitario Lisboa Central, EPE - Hospital dos Capuchos /ID# 160675
city: Lisboa
country: Portugal
facility: Centro Hospitalar de Lisboa Ocidental, EPE - Hospital Egas Moniz /ID# 167749
city: Lisboa
country: Portugal
facility: Centro Hospitalar Universitário de Lisboa Norte, EPE - Hospital de Santa Maria /ID# 160694
city: Loures
country: Portugal
facility: Hospital Beatriz Ângelo /ID# 207757
city: Porto
country: Portugal
facility: Centro Hospitalar Universitario de Sao Joao, EPE /ID# 160695
city: Viseu
country: Portugal
facility: Centro Hosp de Tondela-Viseu /ID# 160697
city: Sector 2
country: Romania
facility: Institutul Clinic Fundeni /ID# 163046
state: Bucuresti
city: Sector 2
country: Romania
facility: Institutul Clinic Fundeni /ID# 163264
state: Bucuresti
city: Cluj
country: Romania
facility: Tvm Med Serv Srl /Id# 166294
city: Timisoara
country: Romania
facility: Duplicate_Centrul Medical Tuculanu SRL /ID# 166295
city: Timișoara
country: Romania
facility: Cabinet Particular Policlinic Algomed /ID# 163047
city: Kemerovo
country: Russian Federation
facility: Kuzbass Regional Clinical Hospital /ID# 161310
state: Kemerovskaya Oblast
city: Perm
country: Russian Federation
facility: Duplicate_Perm state medical university n.a. E.A. Vagner /ID# 207440
state: Permskiy Kray
city: Saint Petersburg
country: Russian Federation
facility: Duplicate_St. Petersburg State Pediatric Medical University /ID# 211977
state: Sankt-Peterburg
city: Stavropol
country: Russian Federation
facility: Professor Pasechnikov Gastroenterology and Pankreatology clinic /ID# 156949
state: Stavropol Skiy Kray
city: Tver
country: Russian Federation
facility: Tver Regional Clinical Hospital /ID# 205925
state: Tverskaya Oblast
city: Tyumen
country: Russian Federation
facility: Regional Clinical Hospital #1 /ID# 163453
state: Tyumenskaya Oblast
city: Izhevsk
country: Russian Federation
facility: Alliance Biomedical Ural Group /ID# 156950
state: Udmurtskaya Respublika
city: Moscow
country: Russian Federation
facility: State Scientific Ctr Coloproct /ID# 204809
city: Novosibirsk
country: Russian Federation
facility: Novosibirski Gastrocenter /ID# 217554
city: St. Petersburg
country: Russian Federation
facility: City Clinical Hospital No. 31 /ID# 208866
city: Ulyanovsk
country: Russian Federation
facility: Duplicate_Ulyanovsk State clinical hospi /ID# 156946
city: Belgrade
country: Serbia
facility: Clinical Hosp Center Zvezdara /ID# 156978
state: Beograd
city: Belgrade
country: Serbia
facility: Military Medical Academy /ID# 156979
state: Beograd
city: Belgrade
country: Serbia
facility: University Clinical Center Serbia /ID# 156973
state: Beograd
city: Belgrade
country: Serbia
facility: Clin Hosp Ctr Bezanijska Kosa /ID# 156976
state: Beograd
city: Kragujevac
country: Serbia
facility: University Clinical Center Kragujevac /ID# 156975
state: Sumadijski Okrug
city: Novi Sad
country: Serbia
facility: Clinical Center Vojvodina /ID# 156972
state: Vojvodina
city: Belgrade
country: Serbia
facility: University Children's Hospital 'Tirsova' /ID# 211481
city: Belgrade
country: Serbia
facility: Clinical Hospital Center Dr Dragisa Misovic - Dedinje /ID# 212797
city: Leskovac
country: Serbia
facility: General Hospital Leskovac /ID# 209574
city: Singapore
country: Singapore
facility: National University Hospital /ID# 160658
city: Singapore
country: Singapore
facility: Singapore General Hospital /ID# 160657
city: Singapore
country: Singapore
facility: KL Ling Gastroenterology and Liver Clinic /ID# 205737
city: Banska Bystrica
country: Slovakia
facility: Fakultna nemocnica s poliklinikou F.D. Roosevelta Banska Bystrica /ID# 156465
city: Martin
country: Slovakia
facility: Univerzitna nemocnica Martin /ID# 163200
city: Nitra
country: Slovakia
facility: KM Management, spol. s.r.o. /ID# 206763
city: Presov
country: Slovakia
facility: GASTRO I., s.r.o. /ID# 156466
city: Johannesburg
country: South Africa
facility: Clinresco Centers /ID# 163864
state: Gauteng
city: Johannesburg
country: South Africa
facility: Wits Clinical Research Site /ID# 158115
state: Gauteng
city: CAPE TOWN Milnerton
country: South Africa
facility: Spoke Research Inc /ID# 158117
state: Western Cape
city: Cape Town
country: South Africa
facility: Kingsbury Hospital /ID# 163116
state: Western Cape
city: Cape Town
country: South Africa
facility: Private Practice Dr MN Rajabally /ID# 163115
state: Western Cape
city: Ferrol
country: Spain
facility: Hospital Arquitecto Marcide - Complejo Hospitalario Universitario de Ferrol /ID# 157527
state: A Coruna
city: Sabadell
country: Spain
facility: Consorci Corporacio Sanitaria Parc Tauli Sabadell /ID# 159230
state: Barcelona
city: Majadahonda
country: Spain
facility: Hospital Universitario Puerta de Hierro, Majadahonda /ID# 157575
state: Madrid
city: Bilbao
country: Spain
facility: Hospital Universitario Basurto /ID# 205189
state: Vizcaya
city: Barcelona
country: Spain
facility: Hospital Clinic de Barcelona /ID# 157526
city: Madrid
country: Spain
facility: Hospital General Universitario Gregorio Maranon /ID# 161435
city: Madrid
country: Spain
facility: Hospital Universitario La Paz /ID# 159228
city: Salamanca
country: Spain
facility: Hospital Clinico Universitario de Salamanca /ID# 157532
city: Sevilla
country: Spain
facility: Hospital Universitario Virgen Macarena /ID# 160819
city: Valencia
country: Spain
facility: Hospital Universitario y Politecnico La Fe /ID# 157530
city: Zaragoza
country: Spain
facility: Hospital Clinico Universitario Lozano Blesa /ID# 212523
city: Zaragoza
country: Spain
facility: Hospital Universitario Miguel Servet /ID# 157531
city: Malmo
country: Sweden
facility: Skane University hospital /ID# 211235
state: Skane Lan
city: Stockholm
country: Sweden
facility: Duplicate_GHP Stockholm Gastro Center /ID# 210479
state: Stockholms Lan
city: Stockholm
country: Sweden
facility: Ersta diakoni /ID# 157878
state: Stockholms Lan
city: Stockholm
country: Sweden
facility: Danderyd Hospital /ID# 202136
state: Stockholms Lan
city: Gothenburg
country: Sweden
facility: Sahlgrenska University Hospital /ID# 157879
state: Vastra Gotalands Lan
city: Molndal
country: Sweden
facility: Duplicate_SU Molndal. /ID# 157880
city: Solna
country: Sweden
facility: Duplicate_Karolinska Univ Sjukhuset /ID# 209966
city: Zürich
country: Switzerland
facility: Universitätsspital Zürich /ID# 163532
state: Zuerich
city: Basel
country: Switzerland
facility: Duplicate_Universitaetsspital Basel /ID# 164555
city: Bern
country: Switzerland
facility: Inselspital, Universitätsspital Bern /ID# 163531
city: Vinnytsia
country: Ukraine
facility: Scientific Research Institute of Invalid Rehabilitation /ID# 211516
state: Vinnytska Oblast
city: Kharkiv
country: Ukraine
facility: Kharkiv City Clinical Hospital No.2 n.a. Prof. O.O. Shalimov /ID# 165649
city: Kherson
country: Ukraine
facility: Municipal Nonprofit Enterprise Kherson city clinical hospital n.a. Y.Y. Karabel /ID# 212050
city: Kyiv
country: Ukraine
facility: International Institute of Clinical Research LLC /ID# 211997
city: Kyiv
country: Ukraine
facility: Communal Noncommercial Institution Consultative and Diagnostic Center of Desnian /ID# 165651
city: Kyiv
country: Ukraine
facility: Medical Center of LLC Medbud-Clinic /ID# 216929
city: Kyiv
country: Ukraine
facility: Kyiv Railway Clinical Hosp No.2 /ID# 217330
city: Lutsk
country: Ukraine
facility: Communal Enterprise Volyn Regional Clinical hospital of the Volyn Regional Coun /ID# 206788
city: Lviv
country: Ukraine
facility: Lviv Railway Clinical Hospital of branch Healthcare Centers of Public Joint Stoc /ID# 165650
city: Uzhhorod
country: Ukraine
facility: Duplicate_Transcarpathian Regional Clin. /ID# 168419
city: Vinnytsia
country: Ukraine
facility: MNPE Vinnytsia Regional Clinical Hospital n.a. M.I. Pyrohov /ID# 216265
city: Київ
country: Ukraine
facility: Kyiv Municipal Clinical Hospital #18 /ID# 162521
city: Exeter
country: United Kingdom
facility: Royal Devon and Exeter NHS Trust Hospital /ID# 157517
state: Devon
city: London
country: United Kingdom
facility: Barts Health NHS Trust /ID# 163710
state: London, City Of
city: London
country: United Kingdom
facility: Guy's and St Thomas' NHS Foundation Trust /ID# 157519
state: London, City Of
city: Chertsey
country: United Kingdom
facility: Ashford and St Peter's Hospitals NHS Foundation Trust /ID# 207937
state: Surrey
city: Cambridge
country: United Kingdom
facility: Cambridge University Hospitals NHS Foundation Trust /ID# 158031
city: Edinburgh
country: United Kingdom
facility: NHS Lothian /ID# 207447
city: Huddersfield
country: United Kingdom
facility: Calderdale and Huddersfield NHS Foundation Trust /ID# 209569
city: Hull
country: United Kingdom
facility: Hull University Teaching Hospitals NHS Trust /ID# 158757
city: Leeds
country: United Kingdom
facility: Leeds Teaching Hospitals NHS Trust /ID# 157523
city: London
country: United Kingdom
facility: Duplicate_King's College Hospital NHS Foundation Trusts /ID# 158756
city: Newcastle Upon Tyne
country: United Kingdom
facility: The Newcastle Upon Tyne Hospitals NHS Foundation Trust /ID# 163709
city: Oxford
country: United Kingdom
facility: Oxford University Hospitals NHS Foundation Trust /ID# 158033
city: Salford
country: United Kingdom
facility: Duplicate_Northern Care Alliance NHS Group /ID# 207764
Study officials:
affiliation: AbbVie
name: ABBVIE INC.
role: STUDY_DIRECTOR
References:
citation: D'Haens G, Panaccione R, Baert F, Bossuyt P, Colombel JF, Danese S, Dubinsky M, Feagan BG, Hisamatsu T, Lim A, Lindsay JO, Loftus EV Jr, Panes J, Peyrin-Biroulet L, Ran Z, Rubin DT, Sandborn WJ, Schreiber S, Neimark E, Song A, Kligys K, Pang Y, Pivorunas V, Berg S, Duan WR, Huang B, Kalabic J, Liao X, Robinson A, Wallace K, Ferrante M. Risankizumab as induction therapy for Crohn's disease: results from the phase 3 ADVANCE and MOTIVATE induction trials. Lancet. 2022 May 28;399(10340):2015-2030. doi: 10.1016/S0140-6736(22)00467-6.