Clinical trial NCT00091637: Pexelizumab in Conjunction With Angioplasty in Acute Myocardial Infarction (APEX-AMI)
Official title: APEX-AMI - Pexelizumab in Conjunction With Angioplasty
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE3
Conditions: Acute Myocardial Infarction
Lead sponsor: Procter and Gamble
Sponsor class: INDUSTRY
First posted: 2004-09-16
Enrollment: 5745
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: In the setting of reperfusion therapy in an acute myocardial infarction using primary percutaneous intervention (PCI), the body's own inflammatory system involving the complement cascade may be harmful. This study will test the safety and efficacy of a novel complement inhibitor, pexelizumab to reduce mortality at 30 days.


Eligibility criteria: Inclusion Criteria:

* Cardiac symptoms for at least 20 minutes within past 6 hours;
* Will undergo primary PCI;
* Has ECG evidence of acute high risk ST elevation myocardial infarction;
* Willing and able to be followed for at least 12 months.

Exclusion Criteria:

* Isolated low risk inferior wall myocardial infarction;
* Received fibrinolytic therapy;
* History of complement deficiency;
* Suspected neisserial infection;
* Participating in other investigational study;
* Pregnancy;
* Previous enrollment.

Primary outcomes:
measure: Reduction of all causes of mortality
timeFrame: day 30
Secondary outcomes:
Other outcomes:
Locations:
city: Huntsville
country: United States
facility: Huntsville Hospital
state: Alabama
city: Phoenix
country: United States
facility: Mayo Clinic Hospital
state: Arizona
city: Phoenix
country: United States
facility: North Phoenix Heart Center
state: Arizona
city: Tucson
country: United States
facility: Northwest Medical Center
state: Arizona
city: Fort Smith
country: United States
facility: Sparks Regional Medical Center
state: Arkansas
city: Little Rock
country: United States
facility: Arkansas State Hospital
state: Arkansas
city: Beverly Hills
country: United States
facility: Brotman Medical Center
state: California
city: Burbank
country: United States
facility: Providence Saint Joseph Medical Center
state: California
city: Escondido
country: United States
facility: Palomar Medical Center
state: California
city: Los Angeles
country: United States
facility: Los Angeles Community Hospital
state: California
city: Modesto
country: United States
facility: Memorial Medical Center
state: California
city: Sacramento
country: United States
facility: Sutter Memorial Hospital
state: California
city: San Diego
country: United States
facility: University of CA, San Diego Medical
state: California
city: Santa Rosa
country: United States
facility: Sutter Medical Center of Santa Rosa
state: California
city: Valencia
country: United States
facility: Providence Holy Cross Medical Center
state: California
city: Denver
country: United States
facility: University of Colorado Hospital
state: Colorado
city: Bridgeport
country: United States
facility: St. Vincent Medical Center
state: Connecticut
city: Farmington
country: United States
facility: University of Connecticut Health Center
state: Connecticut
city: New Haven
country: United States
facility: Yale - New Haven
state: Connecticut
city: Washington
country: United States
facility: George Washington University Hospital
state: District of Columbia
city: Atlantis
country: United States
facility: JFK Medical Center
state: Florida
city: Clearwater
country: United States
facility: Morton Plant Hospital
state: Florida
city: Fort Lauderdale
country: United States
facility: North Ridge Medical Center
state: Florida
city: Jacksonville
country: United States
facility: St. Luke's Hospital
state: Florida
city: Melbourne
country: United States
facility: Health First Holmes Regional Medical Center
state: Florida
city: Orlando
country: United States
facility: Florida Heart Hospital
state: Florida
city: Sarasota
country: United States
facility: Sarasota Memorial Hospital
state: Florida
city: Tampa
country: United States
facility: University Community Hospital
state: Florida
city: Boise
country: United States
facility: St. Luke's Regional Medical Center
state: Idaho
city: Bannockburn
country: United States
facility: Highland Park Hospital
state: Illinois
city: Harvey
country: United States
facility: Ingalls Hospital
state: Illinois
city: Lombard
country: United States
facility: Advocate Good Samaritan
state: Illinois
city: Lombard
country: United States
facility: Elmhurst Hospital
state: Illinois
city: Moline
country: United States
facility: Trinity Medical Center
state: Illinois
city: Peoria
country: United States
facility: Saint Francis Medical Center
state: Illinois
city: Rock Island
country: United States
facility: Trinity Medical Center
state: Illinois
city: Indianapolis
country: United States
facility: Methodist Hospital
state: Indiana
city: Indianapolis
country: United States
facility: VAMC
state: Indiana
city: Indianapolis
country: United States
facility: Community Hospital South
state: Indiana
city: Indianapolis
country: United States
facility: The Indiana Heart Hospital
state: Indiana
city: Munster
country: United States
facility: Munster Community Hospital
state: Indiana
city: Des Moines
country: United States
facility: Iowa Heart
state: Iowa
city: Wichita
country: United States
facility: Via Christi Reginal Medical Center
state: Kansas
city: Lexington
country: United States
facility: Central Baptist Hospital
state: Kentucky
city: Lexington
country: United States
facility: University of Kentucky
state: Kentucky
city: Louisville
country: United States
facility: The Jewish Hospital
state: Kentucky
city: Louisville
country: United States
facility: Baptist Hospital East
state: Kentucky
city: Chalmette
country: United States
facility: Lousiana Heart Center
state: Louisiana
city: Lacombe
country: United States
facility: Lousiana Heart Hospital
state: Louisiana
city: New Orleans
country: United States
facility: MCLNO at New Orleans University Campus
state: Louisiana
city: New Orleans
country: United States
facility: Tulane University Hospital and Clinic
state: Louisiana
city: Bangor
country: United States
facility: Eastern Maine Medical Center
state: Maine
city: Portland
country: United States
facility: Maine Medical Center
state: Maine
city: Towson
country: United States
facility: St. Joseph Medical Center
state: Maryland
city: Dearborn
country: United States
facility: Oakwood Hospital and Medical Center
state: Michigan
city: Detroit
country: United States
facility: Henry Ford Hospital
state: Michigan
city: Detroit
country: United States
facility: Sinai-Grace Hospital
state: Michigan
city: Grand Rapids
country: United States
facility: Spectrum Health
state: Michigan
city: Kalamazoo
country: United States
facility: Borgess Medical Center
state: Michigan
city: Muskegon
country: United States
facility: Mercy General Health Partners
state: Michigan
city: Petoskey
country: United States
facility: Northern Michigan Hospital
state: Michigan
city: Pontiac
country: United States
facility: St. Joseph Mercy-Oakland
state: Michigan
city: Royal Oak
country: United States
facility: William Beaumont Hospital
state: Michigan
city: Saginaw
country: United States
facility: Covenant Medical Center
state: Michigan
city: Saginaw
country: United States
facility: Saint Mary Medical Center
state: Michigan
city: Southfield
country: United States
facility: Providence Hospital
state: Michigan
city: Troy
country: United States
facility: William Beaumont Hospital
state: Michigan
city: Warren
country: United States
facility: Harper University Hospital
state: Michigan
city: Coon Rapids
country: United States
facility: Mercy Hospital
state: Minnesota
city: Duluth
country: United States
facility: St. Mary's Duluth Clinic Health System
state: Minnesota
city: Edina
country: United States
facility: Fairview Southdale Hospital
state: Minnesota
city: Minneapolis
country: United States
facility: Abbott Northwestern Hospital
state: Minnesota
city: Minneapolis
country: United States
facility: North Memorial Medical Center
state: Minnesota
city: Rochester
country: United States
facility: Saint Mary Hospital
state: Minnesota
city: Saint Cloud
country: United States
facility: St. Cloud Hospital
state: Minnesota
city: Saint Louis Park
country: United States
facility: Methodist Hospital
state: Minnesota
city: Saint Paul
country: United States
facility: Health East St. Joseph Hospital
state: Minnesota
city: Columbia
country: United States
facility: University of Missouri Health Sciences Center
state: Missouri
city: Saint Louis
country: United States
facility: St. Louis University Hospital
state: Missouri
city: Saint Louis
country: United States
facility: Barnes St. Peters Hospital
state: Missouri
city: Springfield
country: United States
facility: St. John's Hospital
state: Missouri
city: Billings
country: United States
facility: Deaconess Billings Clinic
state: Montana
city: Lincoln
country: United States
facility: St. Elizabeth Medical Center
state: Nebraska
city: Las Vegas
country: United States
facility: Sunrise Hospital
state: Nevada
city: Elizabeth
country: United States
facility: Trinitas Hospital
state: New Jersey
city: Fair Lawn
country: United States
facility: St. Joseph's Regional Medical Center
state: New Jersey
city: Albuquerque
country: United States
facility: New Mexico Heart Institute
state: New Mexico
city: Albany
country: United States
facility: Albany Medical Center
state: New York
city: Bronx
country: United States
facility: Monteflore Medical Center
state: New York
city: Brooklyn
country: United States
facility: Maimonides Medical Center
state: New York
city: Johnson City
country: United States
facility: Wilson Memorial Medical Center
state: New York
city: Mineola
country: United States
facility: Winthrop University Hospital
state: New York
city: New York
country: United States
facility: St. Vincent's Catholic Medical Center
state: New York
city: New York
country: United States
facility: Bellevue Hospital Center
state: New York
city: Poughkeepsie
country: United States
facility: Vassar Brothers Medical Center
state: New York
city: Rochester
country: United States
facility: Rochester General Hospital
state: New York
city: Syracuse
country: United States
facility: SUNY - Upstate Medical University
state: New York
city: Charlotte
country: United States
facility: Presbyterian Hospital
state: North Carolina
city: Durham
country: United States
facility: Duke University Health Systems
state: North Carolina
city: Greensboro
country: United States
facility: Moses Cone Hospital/LeBauer Healthcare
state: North Carolina
city: Greenville
country: United States
facility: Pitt County Memorial Hospital
state: North Carolina
city: High Point
country: United States
facility: High Point Regional Health System
state: North Carolina
city: Minot
country: United States
facility: Trinity Hospital
state: North Dakota
city: Akron
country: United States
facility: Akron General Medical Center
state: Ohio
city: Cincinnati
country: United States
facility: VAMC Cincinnati
state: Ohio
city: Cincinnati
country: United States
facility: Bethesda North Hospital
state: Ohio
city: Cincinnati
country: United States
facility: The University Hospital
state: Ohio
city: Cleveland
country: United States
facility: University Hospitals of Cleveland
state: Ohio
city: Cleveland
country: United States
facility: Cleveland Clinic Foundation
state: Ohio
city: Columbus
country: United States
facility: MidWest Cardiology Research Foundation
state: Ohio
city: Mansfield
country: United States
facility: Med Central Mansfield
state: Ohio
city: Zanesville
country: United States
facility: Genesis Healthcare System
state: Ohio
city: Midwest City
country: United States
facility: Midwest Regional Medical Center
state: Oklahoma
city: Oklahoma City
country: United States
facility: University of Oklahoma Health Sciences Center
state: Oklahoma
city: Oklahoma City
country: United States
facility: VA Medical Center
state: Oklahoma
city: Oklahoma City
country: United States
facility: Integris Baptist Medical Center, Inc.
state: Oklahoma
city: Oklahoma City
country: United States
facility: Oklahoma Heart Hospital
state: Oklahoma
city: Bend
country: United States
facility: St. Charles Medical Center
state: Oregon
city: Portland
country: United States
facility: Providence Portland Medical Center
state: Oregon
city: Allentown
country: United States
facility: Lehigh Valley Hospital
state: Pennsylvania
city: Danville
country: United States
facility: Geisinger Medical Center
state: Pennsylvania
city: Davenport
country: United States
facility: Genesis Medical Center
state: Pennsylvania
city: Erie
country: United States
facility: Hamot Medical Center
state: Pennsylvania
city: Hershey
country: United States
facility: Penn State Milton S. Hershey Medical Center
state: Pennsylvania
city: Lancaster
country: United States
facility: Lancaster General Hospital
state: Pennsylvania
city: Philadelphia
country: United States
facility: Hospital of the University of Pennsylvania
state: Pennsylvania
city: Philadelphia
country: United States
facility: Temple University Hospital
state: Pennsylvania
city: Pittsburgh
country: United States
facility: Jefferson Regional Medical Center
state: Pennsylvania
city: Pittsburgh
country: United States
facility: Allegheny General Hospital
state: Pennsylvania
city: Pittsburgh
country: United States
facility: Western Pennsylvania Hospital
state: Pennsylvania
city: Pittsburgh
country: United States
facility: VA Pittsburgh Healthcare System
state: Pennsylvania
city: West Chester
country: United States
facility: The Chester County Hospital
state: Pennsylvania
city: York
country: United States
facility: York Hospital
state: Pennsylvania
city: Providence
country: United States
facility: Rhode Island Hospital
state: Rhode Island
city: Columbia
country: United States
facility: Palmetto Richland Memorial Hospital
state: South Carolina
city: Columbia
country: United States
facility: Sisters of Charity Providence Hospitals
state: South Carolina
city: Rapid City
country: United States
facility: Rapid City Regional Hospital
state: South Dakota
city: Sioux Falls
country: United States
facility: Heart Hospital of South Dakota
state: South Dakota
city: Jackson
country: United States
facility: Jackson-Madison County General Hospital
state: Tennessee
city: Kingsport
country: United States
facility: Wellmont Holston Valley Medical Center
state: Tennessee
city: Knoxville
country: United States
facility: Fort Sanders Rgional Medical Center
state: Tennessee
city: Knoxville
country: United States
facility: Baptist Hospital of East Tennessee
state: Tennessee
city: Nashville
country: United States
facility: Centennial Medical Center
state: Tennessee
city: Oak Ridge
country: United States
facility: Methodist Medical Center
state: Tennessee
city: Amarillo
country: United States
facility: Northwest Texas Healthcare System
state: Texas
city: Austin
country: United States
facility: Seton Medical Center
state: Texas
city: Dallas
country: United States
facility: Presbyterian Hospital of Dallas
state: Texas
city: Dallas
country: United States
facility: Medical City Dallas
state: Texas
city: Dallas
country: United States
facility: Dallas Medical Center
state: Texas
city: Dallas
country: United States
facility: Parkland Health & Hospital System
state: Texas
city: Fort Sam Houston
country: United States
facility: Brooke Army Medical Center
state: Texas
city: Houston
country: United States
facility: Ben Taub General Hospital
state: Texas
city: Houston
country: United States
facility: Memorial Hermann Hospital
state: Texas
city: Houston
country: United States
facility: Michael E. DeBakey VA Medical Center
state: Texas
city: Houston
country: United States
facility: Houston Northwest Medical Center
state: Texas
city: Lubbock
country: United States
facility: Covenant Medical Center
state: Texas
city: San Antonio
country: United States
facility: Northeast Baptist Hospital
state: Texas
city: San Antonio
country: United States
facility: South Texas Veterans Health Care System Audie L. Murphy Division
state: Texas
city: Temple
country: United States
facility: Scott & White Memorial Hospital
state: Texas
city: Tyler
country: United States
facility: East Texas Medical Center
state: Texas
city: Tyler
country: United States
facility: Trinity Mother Frances Hospital
state: Texas
city: Victoria
country: United States
facility: Citizens Medical Center
state: Texas
city: Victoria
country: United States
facility: Detar Hospital
state: Texas
city: Murray
country: United States
facility: Cottonwood Hospital
state: Utah
city: Alexandria
country: United States
facility: Inova Alexandria Hospital
state: Virginia
city: Charlottesville
country: United States
facility: Universitiy of Virginia Health Science Center
state: Virginia
city: Harrisonburg
country: United States
facility: Rockingham Memorial Hospital
state: Virginia
city: Lynchburg
country: United States
facility: Lynchburg General Hospital
state: Virginia
city: Richmond
country: United States
facility: Herrico Doctors' Hospital - Forest
state: Virginia
city: Virginia Beach
country: United States
facility: Sentara Virginia Beach General Hospital
state: Virginia
city: Winchester
country: United States
facility: Winchester Medical Center
state: Virginia
city: Bellevue
country: United States
facility: Overtake Hospital Medical Center
state: Washington
city: Mount Vernon
country: United States
facility: Skagit Valley Hospital
state: Washington
city: Seattle
country: United States
facility: Harborview Medical Center
state: Washington
city: Tacoma
country: United States
facility: MultiCare Medical Center (Tacoma General Hospital)
state: Washington
city: Tacoma
country: United States
facility: St. Joseph Medical Center
state: Washington
city: Morgantown
country: United States
facility: West Virginia University Hospital
state: West Virginia
city: La Crosse
country: United States
facility: Franciscan Skemp Healthcare
state: Wisconsin
city: Milwaukee
country: United States
facility: Froedtert Hospital
state: Wisconsin
city: Waukesha
country: United States
facility: Waukesha Memorial Hospital
state: Wisconsin
city: Garran
country: Australia
facility: Canberra Hospital
state: Australian Capital Territory
city: Concord
country: Australia
facility: Concord Hospital
state: New South Wales
city: Gosford
country: Australia
facility: Gosford Hospital
state: New South Wales
city: Kogarah
country: Australia
facility: St. George Hospital
state: New South Wales
city: Liverpool
country: Australia
facility: Liverpool Hospital
state: New South Wales
city: Randwick
country: Australia
facility: Prince of Wales Hospital
state: New South Wales
city: St. Leonards
country: Australia
facility: Royal North Shore Hospital
state: New South Wales
city: Chermside
country: Australia
facility: Prince Charles Hospital
state: Queensland
city: Douglas
country: Australia
facility: Townsville Hospital
state: Queensland
city: Wooloong Abba
country: Australia
facility: Princess Alexandra Hospital
state: Queensland
city: Adelaide
country: Australia
facility: Royal Adelaide Hospital
state: South Australia
city: Bedford Park
country: Australia
facility: Flinders Medical Centre
state: South Australia
city: Woodville South
country: Australia
facility: The Queen Elizabeth Hospital
state: South Australia
city: Box Hill
country: Australia
facility: Austin Hospital
state: Victoria
city: Box Hill
country: Australia
facility: Box Hill Hospital
state: Victoria
city: Clayton
country: Australia
facility: Monash Medical Centre
state: Victoria
city: Parkville
country: Australia
facility: Royal Melbourne Hospital
state: Victoria
city: Richmond
country: Australia
facility: Victorian Heart Clinic
state: Victoria
city: Fremantle
country: Australia
facility: Fremantle Hospital
state: Western Australia
city: Nedlands
country: Australia
facility: Sir Charles Gairdner Hospital
state: Western Australia
city: Perth
country: Australia
facility: Royal Perth Hospital
state: Western Australia
city: Linz
country: Austria
facility: Krankenhaus der Barmherzigen Schwestern
city: Wien
country: Austria
facility: Univ. Klinik f. Innere Medizin II
city: Wien
country: Austria
facility: Wilhelminenspital
city: Leuven
country: Belgium
facility: U.Z. Gasthuisberg
state: Brabant
city: Genk
country: Belgium
facility: ZOL Campus Sint-Jan
state: Limburg
city: Roeselare
country: Belgium
facility: Helig Hartziekenhuis
state: Vlaanderen
city: Antwerpen
country: Belgium
facility: AZ Middelheim
city: Liege
country: Belgium
facility: CHR de la Citadelle
city: Calgary
country: Canada
facility: Foothills Medical Centre
state: Alberta
city: Edmonton
country: Canada
facility: University of Alberta Hospital
state: Alberta
city: Vancouver
country: Canada
facility: Vancouver General Hospital
state: British Columbia
city: Vancouver
country: Canada
facility: St. Paul's Hospital
state: British Columbia
city: Victoria
country: Canada
facility: Royal Jubilee Hospital
state: British Columbia
city: Saint John
country: Canada
facility: Saint John Regional Hospital - New Brunswick Heart Centre
state: New Brunswick
city: St. John's
country: Canada
facility: General Hospital Health Sciences Centre
state: Newfoundland and Labrador
city: Hamilton
country: Canada
facility: Hamilton General Hospital
state: Ontario
city: Mississauga
country: Canada
facility: Trillium Health Center
state: Ontario
city: Toronto
country: Canada
facility: Sunnybrook & Women's Health Sciences Centre
state: Ontario
city: Montreal
country: Canada
facility: Montreal Heart Institute/Research Centre
state: Quebec
city: Montreal
country: Canada
facility: Centre Hospitale de'Universite de Montreal (Pav Notre-Dame)_
state: Quebec
city: Montreal
country: Canada
facility: Hopital Sacre-Coeur de Montreal
state: Quebec
city: Sainte-Foy
country: Canada
facility: Quebec Heart Institute/Laval Hospital
state: Quebec
city: Sherbrooke
country: Canada
facility: Centre Hospitalier Universitaire de Sherbrooke
state: Quebec
city: Regina
country: Canada
facility: Regina General Hospital
state: Saskatchewan
city: Caske Budejovice
country: Czechia
facility: Kardiologicke odd. Nemocnice Ceske Budejovice as
state: Ceske Budejovice
city: Kradec Kralove
country: Czechia
facility: I. Interni klinika, Fakultni nemocnice Hradec
state: Hradec Kralove
city: Prague 4
country: Czechia
facility: Klinika kardiologie, IKEM
state: Prague
city: Labem
country: Czechia
facility: Kardiologicke oddeleni, Masarykova nemocnice
state: Usti Nad Labem
city: Brno
country: Czechia
facility: Interni kardiologicka klinika, Fakultni nemocnice Brno
city: Brno
country: Czechia
facility: I. interni kardioangiologicka klinika, Fakultni nemocnice u Sv. Anny
city: Liberec
country: Czechia
facility: Kardiologicke odd., Krajska neocnice Liberec
city: Olomouc
country: Czechia
facility: I. Interni klinika, FN Olomouc
city: Ostrava
country: Czechia
facility: Interni klinika, FNsP Ostrava
city: Pardubice
country: Czechia
facility: Kardio-Troll sro and Krajska nemocnice Pardubice
city: Pardubice
country: Czechia
facility: Kardio-Troll sro and Krajska nemocnice Pardubice
city: Plzen
country: Czechia
facility: I. Interni klinika, Fakultni nemocnice Plzen
city: Prague
country: Czechia
facility: Kardiocentrum, Fakultni nemocnice Kralovske Vinohrady
city: Prague
country: Czechia
facility: II. Interni klinika, Vseobecna fakultni nemocnice
city: Prague
country: Czechia
facility: Kardiologicke odd., Nemocnice Na Homoice
city: Prague
country: Czechia
facility: Kardiologicka klinika FN v Motole
city: Trinec
country: Czechia
facility: Kardiocentrum, Nemocnice Podlesi sro
city: Zlin
country: Czechia
facility: Interni klinika, Batova nemocnice
city: Aalborg
country: Denmark
facility: Aalborg Sygehus
state: Danmark
city: Aarhus
country: Denmark
facility: Skejby Sygehus
state: Danmark
city: Hellerup
country: Denmark
facility: Amtssygehuset i Gentofte
state: Danmark
city: Kobenhavn
country: Denmark
facility: Rigshospitalet
state: Danmark
city: Odense
country: Denmark
facility: Odense Universitets Hospital
city: Angers
country: France
facility: CHRU de Angers
city: Colmar Cedex
country: France
facility: Clinique Saint Joseph
city: Eaubonne-Montmorency
country: France
facility: Cardiologie Hopital Simone Veil
city: Haguenau
country: France
facility: Centre Hospitalier de Haguenau
city: Nantes
country: France
facility: CHRU de Nantes
city: Paris Cedex 13
country: France
facility: Hopital a Pitie Salpetriere
city: Paris
country: France
facility: Hopital Lariboisiere
city: Paris
country: France
facility: Hopital Bichat
city: Pessac
country: France
facility: Hopital du Haut Leveque
city: Rennes
country: France
facility: Hopital Pontchaillou
city: Rouen
country: France
facility: CHRU de Rouen
city: Saint Denis
country: France
facility: Centre Cardiologique du Nord
city: Strasbourg
country: France
facility: CHRU Hautepierre
city: Toulouse Cedex 9
country: France
facility: Hopital Rangueil
city: Vandoeuvre les Nancy
country: France
facility: Hopital d'adultes de Brabois (CHU de Nancy)
city: Mannheim
country: Germany
facility: Universitatsklinikum Mannheim
state: Baden-Wurttemberg
city: Augsburg
country: Germany
facility: Klinikum Augsburg, Stenglinstr. 2.
state: Bavaria
city: Coburg
country: Germany
facility: Klinikum Coburg
state: Bavaria
city: Munchen
country: Germany
facility: Stadt Krankenhaus Muenchen-Bogenhausen
state: Bavaria
city: Bad Nauheim
country: Germany
facility: Kerckhoff-Klinik Bad Anuheim
state: Hessen
city: Kassel
country: Germany
facility: Stadt. Kliniken Kassel
state: Hessen
city: Celle
country: Germany
facility: Allgemeines Krankenhaus Celle
state: Lower Saxony
city: Gottingen
country: Germany
facility: Herzzentrum Gottingen
state: Lower Saxony
city: Dortmund
country: Germany
facility: St. Johannes Krankenhaus
state: Nordhein Westfalen
city: Duisburg
country: Germany
facility: Herzzentrum Duisburg
state: Nordhein Westfalen
city: Koln
country: Germany
facility: Kliniken der Stadt Koln
state: Nordrhein Westfalen
city: Wuppertal
country: Germany
facility: Helios Klinikum Wuppertal GmbH
state: Nordrhein Westfalen
city: Detmold
country: Germany
facility: Klinikkum Lippe
state: North Rhine-Westphalia
city: Ludwigshafen
country: Germany
facility: Klinikkum Ludwigshafen
state: Rhineland-Palatinate
city: Bad Segeberg
country: Germany
facility: Herzzentrum
state: Schleswig Holstein
city: Lubeck
country: Germany
facility: Universitatsklinik Lubeck
state: Schleswig-Holstein
city: Jena
country: Germany
facility: Klinik fur Innere Medizin 1
state: Thuringia
city: Krozingen
country: Germany
facility: Herz-Zentrum Bad Krozingen
state: Wurrtemberg
city: Bad Oeynhausen
country: Germany
facility: Universitatsklinik der Ruhr-Universitat Bochum
city: Berlin
country: Germany
facility: Vivantes Klinikkum im Friedrichshain
city: Berlin
country: Germany
facility: Vivantes Klinikum am Urban
city: Hamburg
country: Germany
facility: Allgemeines Krankenhaus St. Georg
city: Hamburg
country: Germany
facility: Universitatsklinikum Hamburg-Eppendorf
city: San Donato Milanese
country: Italy
facility: Centro E Malan
state: Milano
city: Cittadella
country: Italy
facility: Presidio Ospedaliero di Cittadella
state: Padova
city: Reggio Nell Emilia
country: Italy
facility: U.O. Cardiologia
state: Reggio Emilla
city: Alessandria
country: Italy
facility: A.O. SS. Antonio e Biagio e Cesare Arrigo
city: Bologna
country: Italy
facility: Policlinico Sant'Orsola-Malpighi
city: Bolzano
country: Italy
facility: Ospedale Centrale di Bolzano
city: Brescia
country: Italy
facility: A.O. Spedali di Civili
city: Como
country: Italy
facility: A.O. della Regione Lombardia Presidio Ospedaliero Sant'Anna
city: Lecco
country: Italy
facility: Ospedale Alessandro Manzoni
city: Mantova
country: Italy
facility: Azienda Ospedaliera Carlo Poma
city: Parma
country: Italy
facility: Azienda Ospedaliera di Parma - Ospedale Maggiore
city: Pavia
country: Italy
facility: Policlinico San Matteo - I.R.C.C.S.
city: Pesaro
country: Italy
facility: A. O. S. Salvatore
city: Rimni
country: Italy
facility: Osepdale degli Intermi
city: Roma
country: Italy
facility: AO S. Camillo Forlanini
city: Torino
country: Italy
facility: Cardiologia Universitaria
city: Treviso
country: Italy
facility: Ospedale S. Maria di Ca'Foncello
city: Eindhovenb
country: Netherlands
facility: Catharina Hospital
state: BR
city: Maastricht
country: Netherlands
facility: Academic Hospital Maastricht
state: LI
city: Alkmaar
country: Netherlands
facility: Medeisch Centrum Alkmaar
state: NH
city: Amsterdam
country: Netherlands
facility: VUMC
state: NH
city: Amsterdam
country: Netherlands
facility: OLVG
state: NH
city: Zwolle
country: Netherlands
facility: Isla Klinieken Location De Weezenlanden
state: OV
city: Nieuwegein
country: Netherlands
facility: Sint Antonius Hospital
state: UT
city: Ultrecht
country: Netherlands
facility: University Medical Center Utrecht
state: UT
city: Rotterdam
country: Netherlands
facility: Erasmus Medical Centre
state: ZH
city: Rotterdam
country: Netherlands
facility: Medisch Centrum Rijnmond-Zuid
state: ZH
city: Christchurch
country: New Zealand
facility: Christchurch Hospital
state: Canterbury
city: Dunedin
country: New Zealand
facility: Dunedin Hospital
state: Otago
city: Hamilton
country: New Zealand
facility: Waikato Hospital
state: Waikoto
city: Auckland
country: New Zealand
facility: Auckland City Hospital
city: Wellington
country: New Zealand
facility: Wellington Hospital
city: Katowice - Ochojec
country: Poland
facility: I Klinika Kardiologii
city: Krakow
country: Poland
facility: Klinika Chorob Serca i Naczyn
city: Lodz
country: Poland
facility: II Katedra i Klinika Kardiologii
city: Warszawa
country: Poland
facility: I Klinika Choroby Wiencowej
city: Wroclaw
country: Poland
facility: SPZOZ Dolnoslaski Szpital Specjalistyczny
city: Almada
country: Portugal
facility: Hospital Garcia de Orta - Servico de Cardiologia
state: Lisboa
city: Carnaxide
country: Portugal
facility: Hospital Santa Cruz
state: Lisboa
city: Amadora
country: Portugal
facility: H. Fernando da Fonesca
city: Coimbra
country: Portugal
facility: Hospitals da Universidade de Coimbra
city: Lisboa
country: Portugal
facility: Hospital Curry Cabral
city: Lisboa
country: Portugal
facility: H. Santa Maria
city: Porto
country: Portugal
facility: Hospital Sao Joao - Servico de Cardiologia
city: Vila Nova De Gala
country: Portugal
facility: Centro Hospitalar de Vila Nova de Gala
city: L'Hospitalet de Llobregat
country: Spain
facility: Ciutat Sanitaria i Universitaria de Bellvitge
state: Barcelona
city: El Palmar
country: Spain
facility: Hospital Virgen da la Arrixaca
state: Murcia
city: Pamplona
country: Spain
facility: Hospital de Navarra
state: Navarra
city: Alicante
country: Spain
facility: Hospital General Universitario de Alicante
city: Barcelona
country: Spain
facility: Hospital Clinic i Provincial
city: Leon
country: Spain
facility: Hospital de Leon
city: Madrid
country: Spain
facility: Hospital General Universitario Gregorio Maranon
city: Madrid
country: Spain
facility: Hospital Puerta de Hierro
city: Madrid
country: Spain
facility: Hospital Clinico San Carlos
city: Malaga
country: Spain
facility: Hospital Clinico Universitario Virgen de la Victoria
city: Sevilla
country: Spain
facility: Hopspital Virgen del Rocio
city: Umea
country: Sweden
facility: Universitetetssjukhuset Umea
city: Uppsala
country: Sweden
facility: Uppsala University Hospital
city: Geneva 14
country: Switzerland
facility: University Hospital of Geneva
state: Geneva
city: St. Gallen
country: Switzerland
facility: Kantonsspital St. Gallen
state: Saint Gallen
city: Kreuzlingen
country: Switzerland
facility: Herzklinik Bodensee am Weinberg AG
state: Thurgau
city: Lugano
country: Switzerland
facility: Cardiocentro Ticino
state: Ticino
city: Bassel
country: Switzerland
facility: Kantonsspital Basel
Study officials:
affiliation: Procter and Gamble
name: Thomas G Todaro, MD, JD, FACC
role: STUDY_DIRECTOR
References:
citation: Bagai A, Armstrong PW, Stebbins A, Mahaffey KW, Hochman JS, Weaver WD, Patel MR, Granger CB, Lopes RD. Prognostic implications of left ventricular end-diastolic pressure during primary percutaneous coronary intervention for ST-segment elevation myocardial infarction: Findings from the Assessment of Pexelizumab in Acute Myocardial Infarction study. Am Heart J. 2013 Nov;166(5):913-9. doi: 10.1016/j.ahj.2013.08.006. Epub 2013 Sep 24.
citation: Guptill JT, Mehta RH, Armstrong PW, Horton J, Laskowitz D, James S, Granger CB, Lopes RD. Stroke after primary percutaneous coronary intervention in patients with ST-segment elevation myocardial infarction: timing, characteristics, and clinical outcomes. Circ Cardiovasc Interv. 2013 Apr;6(2):176-83. doi: 10.1161/CIRCINTERVENTIONS.112.000159. Epub 2013 Apr 2.
citation: Westerhout CM, Pieper KS, James SK, Mahaffey KW, de Werf FV, Califf RM, Granger CB, Armstrong PW. Dynamic modeling of 90-day mortality in ST-elevation myocardial infarction patients undergoing primary percutaneous coronary intervention. Am Heart J. 2013 Mar;165(3):354-62.e2. doi: 10.1016/j.ahj.2012.12.001. Epub 2013 Jan 15.
citation: Patel MR, Westerhout CM, Granger CB, Brener SJ, Fu Y, Siha H, Kim RJ, Armstrong PW. Aborted myocardial infarction after primary percutaneous coronary intervention: magnetic resonance imaging insights from the Assessment of Pexelizumab in Acute Myocardial Infarction (APEX-AMI) trial. Am Heart J. 2013 Feb;165(2):226-33. doi: 10.1016/j.ahj.2012.10.028. Epub 2012 Nov 24.
citation: Truffa AA, Granger CB, White KR, Newby LK, Mehta RH, Hochman JS, Patel MR, Pieper KS, Al-Khalidi HR, Armstrong PW, Lopes RD. Serious infection after acute myocardial infarction: incidence, clinical features, and outcomes. JACC Cardiovasc Interv. 2012 Jul;5(7):769-76. doi: 10.1016/j.jcin.2012.03.018.
citation: Martel C, Granger CB, Ghitescu M, Stebbins A, Fortier A, Armstrong PW, Bonnefoy A, Theroux P. Pexelizumab fails to inhibit assembly of the terminal complement complex in patients with ST-elevation myocardial infarction undergoing primary percutaneous coronary intervention. Insight from a substudy of the Assessment of Pexelizumab in Acute Myocardial Infarction (APEX-AMI) trial. Am Heart J. 2012 Jul;164(1):43-51. doi: 10.1016/j.ahj.2012.04.007. Epub 2012 Jun 15.
citation: van Diepen S, Widimsky P, Lopes RD, White KR, Weaver WD, Van de Werf F, Ardissino D, van't Hof AW, Armstrong PW, Granger CB. Transfer times and outcomes in patients with ST-segment-elevation myocardial infarction undergoing interhospital transfer for primary percutaneous coronary intervention: APEX-AMI insights. Circ Cardiovasc Qual Outcomes. 2012 Jul 1;5(4):437-44. doi: 10.1161/CIRCOUTCOMES.112.965160. Epub 2012 May 15.
citation: Hudson MP, Armstrong PW, O'Neil WW, Stebbins AL, Weaver WD, Widimsky P, Aylward PE, Ruzyllo W, Holmes D, Mahaffey KW, Granger CB. Mortality implications of primary percutaneous coronary intervention treatment delays: insights from the Assessment of Pexelizumab in Acute Myocardial Infarction trial. Circ Cardiovasc Qual Outcomes. 2011 Mar;4(2):183-92. doi: 10.1161/CIRCOUTCOMES.110.945311. Epub 2011 Feb 8.
citation: Huber K, Holmes DR Jr, van 't Hof AW, Montalescot G, Aylward PE, Betriu GA, Widimsky P, Westerhout CM, Granger CB, Armstrong PW. Use of glycoprotein IIb/IIIa inhibitors in primary percutaneous coronary intervention: insights from the APEX-AMI trial. Eur Heart J. 2010 Jul;31(14):1708-16. doi: 10.1093/eurheartj/ehq143. Epub 2010 May 25.
citation: Alhadramy O, Westerhout CM, Brener SJ, Granger CB, Armstrong PW; APEX AMI Investigators. Is visual interpretation of coronary epicardial flow reliable in patients with ST-elevation myocardial infarction undergoing primary angioplasty? Insights from the angiographic substudy of the Assessment of Pexelizumab in Acute Myocardial Infarction (APEX-AMI) trial. Am Heart J. 2010 May;159(5):899-904. doi: 10.1016/j.ahj.2010.02.028.
citation: Patel MR, Worthley SG, Stebbins A, Dill T, Rademakers FE, Valeti US, Barsness GW, Van de Werf F, Hamm CW, Armstrong PW, Granger CB, Kim RJ. Pexelizumab and infarct size in patients with acute myocardial infarction undergoing primary percutaneous coronary Intervention: a delayed enhancement cardiac magnetic resonance substudy from the APEX-AMI trial. JACC Cardiovasc Imaging. 2010 Jan;3(1):52-60. doi: 10.1016/j.jcmg.2009.09.014. Epub 2010 Jan 12.
citation: Trendelenburg M, Theroux P, Stebbins A, Granger C, Armstrong P, Pfisterer M. Influence of functional deficiency of complement mannose-binding lectin on outcome of patients with acute ST-elevation myocardial infarction undergoing primary percutaneous coronary intervention. Eur Heart J. 2010 May;31(10):1181-7. doi: 10.1093/eurheartj/ehp597. Epub 2010 Jan 19.
citation: Brener SJ, Westerhout CM, Fu Y, Todaro TG, Moliterno DJ, Wagner GS, Granger CB, Armstrong PW; APEX-AMI Investigators. Contribution of angiographic and electrocardiographic parameters of reperfusion to prediction of mortality and morbidity after acute ST-elevation myocardial infarction: Insights from the Assessment of Pexelizumab in Acute Myocardial Infarction trial. Am Heart J. 2009 Nov;158(5):755-60. doi: 10.1016/j.ahj.2009.09.009. Epub 2009 Oct 3.
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citation: Buller CE, Fu Y, Mahaffey KW, Todaro TG, Adams P, Westerhout CM, White HD, van 't Hof AW, Van de Werf FJ, Wagner GS, Granger CB, Armstrong PW. ST-segment recovery and outcome after primary percutaneous coronary intervention for ST-elevation myocardial infarction: insights from the Assessment of Pexelizumab in Acute Myocardial Infarction (APEX-AMI) trial. Circulation. 2008 Sep 23;118(13):1335-46. doi: 10.1161/CIRCULATIONAHA.108.767772. Epub 2008 Sep 8.
citation: APEX AMI Investigators; Armstrong PW, Granger CB, Adams PX, Hamm C, Holmes D Jr, O'Neill WW, Todaro TG, Vahanian A, Van de Werf F. Pexelizumab for acute ST-elevation myocardial infarction in patients undergoing primary percutaneous coronary intervention: a randomized controlled trial. JAMA. 2007 Jan 3;297(1):43-51. doi: 10.1001/jama.297.1.43.