Clinical trial NCT04777409: A Research Study Investigating Semaglutide in People With Early Alzheimer's Disease (EVOKE Plus)
Official title: A Randomised Double-blind Placebo-controlled Clinical Trial Investigating the Effect and Safety of Oral Semaglutide in Subjects With Early Alzheimer´s Disease (EVOKE Plus)
Study type: INTERVENTIONAL
Overall status: ACTIVE_NOT_RECRUITING
Phase: PHASE3
Conditions: Early Alzheimer´s Disease
Lead sponsor: Novo Nordisk A/S
Sponsor class: INDUSTRY
First posted: 2021-03-02
Enrollment: 1840
Sex: ALL
Minimum age (years): 55
Maximum age (years): 85
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: This study is done to find out whether the medicine, semaglutide, has a positive effect on early Alzheimer's disease.

Participants will either get semaglutide or placebo (a "dummy" medicine which does not contain any study medicine) - which treatment participants get is decided by an equal chance.

The study will last for up to 173 weeks (about 3 years and 4 months). Participants will have 17 clinic visits and 1 phone call with the study doctor. The study includes various tests and scans. At 10 of the clinic visits participants will have blood samples taken.

Participants must have a study partner, who is willing to take part in the study.

Women cannot take part if pregnant, breastfeeding or plan to become pregnant during the study period.

A cerebrospinal fluid (CSF) sub-study will be performed as a part of the study. The sub-study will be performed on a selection of sites based on their experience with CSF sampling and willingness to participate in this sub-study. The endpoints related to this sub-study are exploratory only.


Eligibility criteria: Inclusion Criteria:

* Male or female, aged 55-85 years (both inclusive) at the time of signing informed consent.
* MCI (mild cognitive impairment) or mild dementia of the Alzheimer's type according to the NIA-AA (National Institute of Aging-Alzheimer's Association) 2018 criteria.
* CDR (Clinical Dementia Rating) global score of 0.5 and CDR of 0.5 or more in at least one of the three instrumental activities of daily living categories (personal care, home \& hobbies, community affairs) Or CDR global score of 1.0
* RBANS (Repeatable Battery for the Assessment of Neuropsychological Status) delayed memory index score of below or equal to (≤) 85
* MMSE (Mini-Mental State Examination) greater than or equal to (≥) 22
* Amyloid positivity established with either amyloid PET (positron emission tomography), CSF (cerebrospinal fluid) Aβ1-42 or CSF Aβ1-42/Aβ1-40.
* If receiving an approved Alzheimer's disease treatment (such as acetylcholinesterase inhibitors, memantine or aducanumab) the dose must have been stable for at least 3 months prior to screening and should not be changed during the study unless medically necessary.

Exclusion Criteria:

* Brain Magnetic resonance imaging (MRI) (or Computed Tomography (CT)) scan suggestive of clinically significant structural CNS (central nervous system) disease confirmed by central read (e.g. cerebral large-vessel disease \[large vessel (cortical) infarcts greater than (\>) 10 milimeter (mm) in diameter\], prior macro-haemorrhage \[greater than 1 cubic centimetre (cm\^3)\], cerebral vascular malformations, cortical hemosiderosis, intracranial aneurism(s), intracranial tumours, changes suggestive of normal pressure hydrocephalus).
* Brain MRI (or CT) scan suggestive of strategic infarcts defined as bilateral thalamic lacunar infarcts and singular paramedian thalamic infarcts confirmed by central read.
* Evidence of a relevant neurological disorder other than mild cognitive impairment (MCI) or mild dementia of the Alzheimer's type at screening, including but not limited to Parkinson's disease, Lewy body disease, frontotemporal dementia of any type, Huntington's disease, amyotrophic lateral sclerosis, multiple sclerosis, systemic lupus erythematosus, progressive supranuclear palsy, neurosyphilis, human immunodeficiency virus (HIV), learning disability, intellectual disability, hypoxic cerebral damage, or significant head trauma with loss of consciousness that led to persistent cognitive deficits.
* Evidence of a clinically relevant or unstable psychiatric disorder, based on Diagnostic and Statistical Manual of Mental Disorders (DSM-5) criteria, including schizophrenia or other psychotic disorder, or bipolar disorder. A participant with a history of major depression who has not had an episode in the last 24 months before the day of screening and is considered in remission or whose depression is controlled with treatment can be included in the study per investigator's judgement.

Primary outcomes:
measure: Change in the Clinical Dementia Rating - Sum of Boxes (CDR-SB) score
timeFrame: From baseline (week 0) to week 104
Secondary outcomes:
measure: Main Phase: Change in the 24-item Alzheimer's Disease Cooperative Study Activities of Daily Living Scale for Mild Cognitive Impairment (ADCS-ADL-MCI) score
timeFrame: From baseline (week 0) to week 104
measure: Extension phase: Change in the ADCS-ADL-MCI score
timeFrame: From baseline (week 0) to week 156
measure: Main Phase: Time to progression to Clinical Dementia Rating (CDR) global score greater than or equal to (≥)1.0 among patients with CDR global score equal to (=) 0.5 at baseline
timeFrame: From baseline (week 0) up to week 156
measure: Extension Phase: Time to progression to Clinical Dementia Rating (CDR) global score greater than or equal to (≥)1.0 among patients with CDR global score equal to (=) 0.5 at baseline
timeFrame: From baseline (week 0) to week 156
measure: Main Phase: Change in the 13-item Alzheimer's Disease Assessment Scale - Cognitive Subscale (ADAS-Cog-13) score
timeFrame: From baseline (week 0) to week 104
measure: Extension Phase: Change in the 13-item Alzheimer's Disease Assessment Scale - Cognitive Subscale (ADAS-Cog-13) score
timeFrame: From baseline (week 0) to week 156
measure: Main Phase: Change in the Montreal Cognitive Assessment (MoCA) score
timeFrame: From baseline (week 0) to week 104
measure: Extension Phase: Change in the Montreal Cognitive Assessment (MoCA) score
timeFrame: From baseline (week 0) to week 156
measure: Main Phase: Change in the Alzheimer's Disease Composite Score (ADCOMS)
timeFrame: From baseline (week 0) to week 104
measure: Extension Phase: Change in the Alzheimer's Disease Composite Score (ADCOMS)
timeFrame: From baseline (week 0) to week 156
measure: Main Phase: Change in the Mini-Mental State Examination (MMSE) score
timeFrame: From baseline (week 0) to week 104
measure: Extension Phase: Change in the Mini-Mental State Examination (MMSE) score
timeFrame: From baseline (week 0) to week 156
measure: Main Phase: Time to progression in disease stage based on CDR global score
timeFrame: From baseline (week 0) up to week 156
measure: Extension Phase: Time to progression in disease stage based on CDR global score
timeFrame: From baseline (week 0) to week 156
measure: Main Phase: Change in the composite Z-score based on the three outcome measures CDR-SB, ADCS-ADL-MCI, and ADAS-Cog-13
timeFrame: From baseline (week 0) to week 104
measure: Extension Phase: Change in the composite Z-score based on the three outcome measures CDR-SB, ADCS-ADL-MCI, and ADAS-Cog-13
timeFrame: From baseline (week 0) to week 156
measure: Main Phase: Change in the 10-item Neuropsychiatric Inventory (NPI) score
timeFrame: From baseline (week 0) to week 104
measure: Extension Phase: Change in the 10-item Neuropsychiatric Inventory (NPI) score
timeFrame: From baseline (week 0) to week 156
measure: Main Phase: Change in high sensitivity C-reactive protein level
timeFrame: From baseline (week 0) to week 104
measure: Extension Phase: Change in high sensitivity C-reactive protein level
timeFrame: From baseline (week 0) to week 156
measure: Main Phase: Number of treatment emergent adverse events (TEAEs)
timeFrame: From baseline (week 0) up to week 156
measure: Extension Phase: Number of treatment emergent adverse events (TEAEs)
timeFrame: From baseline (week 0) to week 156
measure: Main Phase: Time to first occurrence of major adverse cardiovascular event (MACE) comprising non-fatal myocardial infarction, non-fatal stroke and allcause death
timeFrame: From baseline (week 0) to week 104
measure: Extension Phase: Time to first occurrence of major adverse cardiovascular event (MACE) comprising non-fatal myocardial infarction, non-fatal stroke and allcause death
timeFrame: From baseline (week 0) to week 156
measure: Main Phase: Time to first occurrence of stroke
timeFrame: From baseline (week 0) to week 104
measure: Extension Phase: Time to first occurrence of stroke
timeFrame: From baseline (week 0) to week 156
measure: Main Phase: Change in the EQ-5D-5L (proxy version) index score
timeFrame: From baseline (week 0) to week 104
measure: Extension Phase: Change in the EQ-5D-5L (proxy version) index score
timeFrame: From baseline (week 0) to week 156
measure: Extension phase: Change in the CDR-SB score
timeFrame: From baseline (week 0) to week 156
Other outcomes:
Locations:
city: Phoenix
country: United States
facility: Banner Alzheimer's Institute
state: Arizona
city: Sun City
country: United States
facility: Banner Sun Health Research Institute
state: Arizona
city: Anaheim
country: United States
facility: Advanced Research Center, Inc.
state: California
city: Lomita
country: United States
facility: Torrance Clin Res Inst, Inc.
state: California
city: Long Beach
country: United States
facility: ASCLEPES Research Centers,
state: California
city: Panorama City
country: United States
facility: Well Care Medical Center
state: California
city: Pasadena
country: United States
facility: Cedars-Sinai Medical Center
state: California
city: San Diego
country: United States
facility: Sharp Neurocog Res Ctr
state: California
city: Santa Ana
country: United States
facility: Syrentis Clinical Research
state: California
city: Sherman Oaks
country: United States
facility: Calfornia Neurosc Resrch Med
state: California
city: Basalt
country: United States
facility: Mountain Neurological Research Center, Inc.
state: Colorado
city: Denver
country: United States
facility: Denver Neurological Research
state: Colorado
city: Denver
country: United States
facility: Mile High Research Center
state: Colorado
city: Danbury
country: United States
facility: Nuvance Health, Associtd Neuro
state: Connecticut
city: Norwalk
country: United States
facility: Research Center for Clinical Studies, Inc
state: Connecticut
city: Atlantis
country: United States
facility: JEM Research Institute
state: Florida
city: Aventura
country: United States
facility: Visionary Investigators Network
state: Florida
city: Delray Beach
country: United States
facility: Brain Matters Research
state: Florida
city: Fort Myers
country: United States
facility: Neuropsychiatric Research Cent
state: Florida
city: Greenacres City
country: United States
facility: Finlay Medical Research Group
state: Florida
city: Hialeah
country: United States
facility: Indago Research & Health Center Inc.
state: Florida
city: Hialeah
country: United States
facility: Hlth Cr Family Rehab & Res Ctr
state: Florida
city: Hialeah
country: United States
facility: Galiz Research
state: Florida
city: Maitland
country: United States
facility: K2 Medical Research, Maitland
state: Florida
city: Miami
country: United States
facility: Hlth Cr Family Rehab & Res Ctr
state: Florida
city: Miami
country: United States
facility: Premier Clin Res Inst, Inc.
state: Florida
city: Miami
country: United States
facility: Premier Clinical Research Institute, Inc.
state: Florida
city: Miami
country: United States
facility: Central Miami Medical Institute
state: Florida
city: Miami
country: United States
facility: Novel Clinical Research Center, LLC
state: Florida
city: Miami
country: United States
facility: IMIC, Inc- Medical Research
state: Florida
city: Miami
country: United States
facility: The Neurology Research Group
state: Florida
city: Miami
country: United States
facility: Visionary Inv Ntwrk_Miami
state: Florida
city: Naples
country: United States
facility: Aqualane Clinical Research
state: Florida
city: New Port Richey
country: United States
facility: Suncoast Clinical Research, Inc._New Port Richey
state: Florida
city: Ocoee
country: United States
facility: K2 Medical Research - Winter Garden
state: Florida
city: Palm Beach Gardens
country: United States
facility: Advanced Research Consultants, Inc.
state: Florida
city: Sarasota
country: United States
facility: Intercoastal Medical Group
state: Florida
city: Stuart
country: United States
facility: Brain Matters Resrch Kane Cntr
state: Florida
city: Tampa
country: United States
facility: Axiom Clinical Research of Florida
state: Florida
city: Tampa
country: United States
facility: Stedman Clinical Trials LLC
state: Florida
city: Winter Park
country: United States
facility: Conquest Research
state: Florida
city: Decatur
country: United States
facility: iResearch Atlanta, LLC
state: Georgia
city: Honolulu
country: United States
facility: Hawaii Neuroscience, Memory Disorders Center
state: Hawaii
city: Meridian
country: United States
facility: Velocity Clinical Research, Meridian
state: Idaho
city: Meridian
country: United States
facility: Velocity Clinical Research
state: Idaho
city: Indianapolis
country: United States
facility: Josephson Wallack Munshower
state: Indiana
city: Topeka
country: United States
facility: Cotton-O'Neil Clinical Research Center
state: Kansas
city: Lexington
country: United States
facility: University of Kentucky_Lexington_0
state: Kentucky
city: Bangor
country: United States
facility: Northern Light Eastern Maine Medical Center
state: Maine
city: Saint Paul
country: United States
facility: HealthPartners Center for Memory and Aging
state: Minnesota
city: Hattiesburg
country: United States
facility: Hattiesburg Clinic
state: Mississippi
city: Las Vegas
country: United States
facility: Wr-Crcn, Llc
state: Nevada
city: Middletown
country: United States
facility: Patient First MD,clinical Trials
state: New Jersey
city: Toms River
country: United States
facility: Advanced Memory Research Institute of NJ
state: New Jersey
city: Lake Success
country: United States
facility: Neurological Assoc Long Island
state: New York
city: Manhasset
country: United States
facility: Feinstein Institute for Medical Research
state: New York
city: Staten Island
country: United States
facility: Richmond Behavioral Associates
state: New York
city: Syracuse
country: United States
facility: SUNY Upstate Medical University_Syracuse
state: New York
city: Charlotte
country: United States
facility: New Hope Clinical Research
state: North Carolina
city: Matthews
country: United States
facility: AMC Research, LLC
state: North Carolina
city: Canton
country: United States
facility: NeuroScience Research Center, LLC
state: Ohio
city: Independence
country: United States
facility: Insight Clinical Trials LLC
state: Ohio
city: Lakewood
country: United States
facility: Cleveland Clinic_Lakewood
state: Ohio
city: Tulsa
country: United States
facility: Central States Research, LLC
state: Oklahoma
city: Portland
country: United States
facility: Summit Research Network Oregon Inc.
state: Oregon
city: Portland
country: United States
facility: Neural Net Research, LLC
state: Oregon
city: Port Royal
country: United States
facility: Coastal Neurology
state: South Carolina
city: Summerville
country: United States
facility: Palmetto Clinical Research
state: South Carolina
city: Knoxville
country: United States
facility: Genesis Neuroscience Clinic
state: Tennessee
city: Nashville
country: United States
facility: Vanderbilt Medical Center
state: Tennessee
city: Austin
country: United States
facility: Texas Diabetes & Endocrinology
state: Texas
city: Houston
country: United States
facility: Balyor College of Medicine
state: Texas
city: Houston
country: United States
facility: Univ Of Texas Hlth Science Cntr
state: Texas
city: Katy
country: United States
facility: Mt. Olympus Medical Research
state: Texas
city: San Antonio
country: United States
facility: Glenn Biggs Inst-Alzhm Neuro
state: Texas
city: Sugar Land
country: United States
facility: Shirzadi Shahin, MD
state: Texas
city: Bennington
country: United States
facility: Memory Clinic, Inc
state: Vermont
city: Falls Church
country: United States
facility: Integrated Neurology Services
state: Virginia
city: Kirkland
country: United States
facility: Booth Gardner Parkinson's Cre
state: Washington
city: Seattle
country: United States
facility: Harborview Medical Center
state: Washington
city: Ciudad de Buenos Aires
country: Argentina
facility: Instituto Medico Especializado_Capital Federal
state: Buenos Aires
city: Buenos Aires
country: Argentina
facility: Instituto de Investigaciones Metabolicas (IDIM)
city: Buenos Aires
country: Argentina
facility: Hospital Italiano
city: Caba
country: Argentina
facility: Clínica Nuestra Señora de las Nieves
city: Caba
country: Argentina
facility: FLENI
city: Córdoba
country: Argentina
facility: Instituto Privado Kremer
city: Mendoza
country: Argentina
facility: Fundación Scherbovsky
city: Darlinghurst
country: Australia
facility: St Vincent's Hospital
state: New South Wales
city: Greenwich
country: Australia
facility: HammondCare Greenwich
state: New South Wales
city: Kogarah
country: Australia
facility: Southern Neurology
state: New South Wales
city: Macquarie Park
country: Australia
facility: KaRa Institute of Neurological Disease Pty Ltd
state: New South Wales
city: Waratah
country: Australia
facility: Hunter New England Local Health District - Neuropsychiatry
state: New South Wales
city: Chermside
country: Australia
facility: The Prince Charles Hospital
state: Queensland
city: Ivanhoe
country: Australia
facility: Medical and Cognitive Research Unit - Austin Health
state: Victoria
city: Malvern
country: Australia
facility: HammondCare
state: Victoria
city: Nedlands
country: Australia
facility: Alzheimer's Research Australia
state: Western Australia
city: Nedlands
country: Australia
facility: Australian Alzheimer's Research Foundation Incorporated
state: Western Australia
city: Innsbruck
country: Austria
facility: LKH-Univ. Kliniken Innsbruck
city: Innsbruck
country: Austria
facility: Medizinische Univ. Innsbruck
city: Salzburg
country: Austria
facility: Univ. Klinik für Neurologie
city: Wien
country: Austria
facility: Medizinische Universität Wien
city: Edegem
country: Belgium
facility: UZA - UZ Antwerpen - Department of Neurology
city: Gent
country: Belgium
facility: UZ Gent - Neurologie
city: Kortrijk
country: Belgium
facility: AZ Groeninge - Kortrijk - Neurologie
city: Leuven
country: Belgium
facility: UZ Leuven - Geheugenkliniek
city: Liège
country: Belgium
facility: Clinique CHC MontLégia - Service Neurologie
city: Brasília
country: Brazil
facility: L2 IP Instituto de Pesquisas Clinicas Ltda
state: Distrito Federal
city: Curitiba
country: Brazil
facility: Instituto de Neurologia de Curitiba
state: Parana
city: Maringa
country: Brazil
facility: Clinica Clinilive Ltda
state: Parana
city: Porto Alegre
country: Brazil
facility: Núcleo de Pesquisa Clínica do Rio Grande do Sul Ltda.
state: Rio Grande Do Sul
city: São Paulo
country: Brazil
facility: CPQuali Pesquisa Clínica Ltda
state: Sao Paulo
city: São Paulo
country: Brazil
facility: BR Trials - Ensaios Clínicos e Consultoria Ltda.
state: Sao Paulo
city: Rio de Janeiro
country: Brazil
facility: Centro de Psiquiatria Sandra Rushel
city: Sofia
country: Bulgaria
facility: "MHATNP "Sv. Naum"" EAD
city: Sofia
country: Bulgaria
facility: DCC Sv. Vrach and Sv. Sv. Kuzma and Damyan
city: Sofia
country: Bulgaria
facility: "UMHAT "Aleksandrovska", Neurology clinic
city: Sofia
country: Bulgaria
facility: MMA, MHAT-Sofia, Neurology clinic
city: Kelowna
country: Canada
facility: OCT Research ULC (dba Okanagan Clinical Trials)
state: British Columbia
city: Victoria
country: Canada
facility: Island Health (Research and Capacity Building)
state: British Columbia
city: West Vancouver
country: Canada
facility: Medical Arts Health Research Group
state: British Columbia
city: Halifax
country: Canada
facility: True North Clinical Research - Halifax
state: Nova Scotia
city: New Minas
country: Canada
facility: True North Clinical Research - New Minas
state: Nova Scotia
city: Ottowa
country: Canada
facility: Recherches Neuro-Hippocampe Inc
state: Ontario
city: Peterborough
country: Canada
facility: Kawartha Centre Redefining Healthy Aging
state: Ontario
city: Toronto
country: Canada
facility: Memory Program
state: Ontario
city: Toronto
country: Canada
facility: Centricity Research LMC
state: Ontario
city: Toronto
country: Canada
facility: Sunnybrook Health Sciences Centre
state: Ontario
city: Toronto
country: Canada
facility: St. Michael's Hospital
state: Ontario
city: Toronto
country: Canada
facility: St. Michael's Hospital
state: Ontario
city: Toronto
country: Canada
facility: University Health Network
state: Ontario
city: Greenfield-Park
country: Canada
facility: MoCA Research Innovation Inc
state: Quebec
city: Montréal
country: Canada
facility: Douglas Hosp Res Ctr
state: Quebec
city: Québec
country: Canada
facility: CHU de Quebec-Universite Laval
state: Quebec
city: Sherbrooke
country: Canada
facility: Diex Recherche Sherbrooke Inc.
state: Quebec
city: Beijing
country: China
facility: Beijing Chao-Yang Hospital, Capital Medical University-Neuro
state: Beijing
city: Beijing
country: China
facility: Beijing Friendship Hospital, Capital Medical University-Neur
state: Beijing
city: Beijing
country: China
facility: Beijing Hospital-Neurology
state: Beijing
city: Beijing
country: China
facility: Xuanwu Hospital Capital Medical University-Neurology
state: Beijing
city: Beijing
country: China
facility: Beijing Tiantan Hospital, Capital Medical University-Neurology Center
state: Beijing
city: Beijing
country: China
facility: Beijing An Ding Hospital Capital Medical University-Geriatric Psychiatry
state: Beijing
city: Beijing
country: China
facility: Peking University Sixth Hospital-Geriatrics
state: Beijing
city: Beijing
country: China
facility: Beijing Huilongguan Hospital-Geriatrics
state: Beijing
city: Beijing
country: China
facility: Peking Union Medical College Hospital-Neurology
state: Beijing
city: Chongqing
country: China
facility: The First Affiliated Hospital of Chongqing Medical University-Geriatrics
state: Chongqing
city: Fuzhou
country: China
facility: Fujian Medical University Union Hospital-Neurology
state: Fujian
city: Guangzhou
country: China
facility: Sun Yat-sen Memorial Hospital, Sun Yat-sen University-Neurol
state: Guangdong
city: Guangzhou
country: China
facility: Guangzhou First People's Hospital-Neurology
state: Guangdong
city: Guangzhou
country: China
facility: The Second affiliated hospital of Guangzhou Medical University-Neurology
state: Guangdong
city: Zhengzhou
country: China
facility: Henan Provincial People's Hospital-Neurology
state: Henan
city: Changsha
country: China
facility: Xiangya Hospital Central South University-Neurology
state: Hunan
city: Baotou
country: China
facility: Baogang Hospital of Inner Mongolia-Neurology
state: Inner Mongolia
city: Nanjing
country: China
facility: Nanjing Brain Hospital-Neurology
state: Jiangsu
city: Nanjing
country: China
facility: Nanjing Drum Tower Hospital-Neurology
state: Jiangsu
city: Nanjing
country: China
facility: Zhongda Hospital Southeast University-Nephrology
state: Jiangsu
city: Wuxi
country: China
facility: Wuxi Mental Health Center-Psychiatry
state: Jiangsu
city: Wuxi
country: China
facility: Wuxi Mental Health Center
state: Jiangsu
city: Yangzhou
country: China
facility: Northern Jiangsu People's Hospital-Neurology
state: Jiangsu
city: Nanchang
country: China
facility: The Second Affiliated Hospital of Nanchang University-Neurol
state: Jiangxi
city: Changchun
country: China
facility: The First Bethune Hospital of Jilin University, Neurology
state: Jilin
city: Xining
country: China
facility: Qinghai Provincial People's Hospital-Geriatrics
state: Qinghai
city: Shanghai
country: China
facility: Huashan Hospital Fudan University-Neurology
state: Shanghai
city: Shanghai
country: China
facility: Dongfang Hospital Affiliated to Shanghai Tongji University-Neurology
state: Shanghai
city: Shanghai
country: China
facility: Shanghai 6th People's Hosp. Affili. to SHJT Univer-Neurology
state: Shanghai
city: Shanghai
country: China
facility: Shanghai Sixth People's Hospital Affiliated to Shanghai JiaoTong University-Neurology
state: Shanghai
city: Chengdu
country: China
facility: West China Hospital Sichuan University-Mental health center
state: Sichuan
city: Tianjin
country: China
facility: General Hospital of Tianjin Medical University-Neurology
state: Tianjin
city: Tianjin
country: China
facility: Tianjin Huanhu Hospital-Neurology
state: Tianjin
city: Hangzhou
country: China
facility: The First Affiliated Hospital of Zhejiang University School of Medicine-Neurology
state: Zhejiang
city: Zagreb
country: Croatia
facility: Poliklinika Solmed
state: Grad Zagreb
city: Zagreb
country: Croatia
facility: KBC Zagreb, Klinika za neurologiju
city: Zagreb
country: Croatia
facility: Poliklinika Bonifarm
city: Brno-Lisen
country: Czechia
facility: Neuro Health Centrum s.r.o.
city: Olomouc
country: Czechia
facility: AGE Centrum
city: Praha 10
country: Czechia
facility: AD71 s.r.o.
city: Praha 6 Dejvice
country: Czechia
facility: Neuropsychiatrie
city: Rychnov nad Kneznou
country: Czechia
facility: Vestra Clinics s.r.o.
city: Aarhus N
country: Denmark
facility: Aarhus Universitetshospital
city: København Ø
country: Denmark
facility: Rigshospitalet - afsnit 8015
city: Roskilde
country: Denmark
facility: Sjællands Universitetshospital_Roskilde
city: Helsinki
country: Finland
facility: CRST Helsinki
city: Kuopio
country: Finland
facility: Aivotutkimusyksikkö
city: Turku
country: Finland
facility: CRST Turku
city: Bordeaux
country: France
facility: Centre Hospitalier Universitaire de Bordeaux-Hopital Pellegrin
city: Bron
country: France
facility: Hospices Civils de Lyon-Hopital Pierre Wertheimer
city: Dijon
country: France
facility: Centre Hospitalier Universitaire de Dijon-Hopital Le Bocage
city: Marseille
country: France
facility: Assistance Publique Hopitaux de Marseille-Hopital de La Timone-1
city: Nice
country: France
facility: Centre Hospitalier Universitaire de Nice-Institut Claude Pompidou
city: Paris
country: France
facility: Aphp-Hopital Lariboisiere-1
city: Paris
country: France
facility: Aphp-Hopital La Pitie Salpetriere-3
city: Reims cedex
country: France
facility: Centre Hospitalier Universitaire Reims-Hopital Maison Blanche
city: Saint Herblain
country: France
facility: Centre Hospitalier Universitaire de Nantes-Hopital Nord Laennec-2
city: Strasbourg
country: France
facility: Les Hopitaux Universitaires de Strasbourg-Hopital de La Robertsau
city: Toulouse
country: France
facility: Centre Hospitalier Universitaire de Toulouse-Hopital La Grave
city: Villeurbanne
country: France
facility: Hospices Civils de Lyon-Hopital Des Charpennes
city: Köln
country: Germany
facility: Universitätsklinikum Köln - Klinik und Poliklinik für Psychiatrie und Psychotherapie
city: Münster
country: Germany
facility: Universitätsklinikum Münster, Neurologie
city: Athens
country: Greece
facility: Henry Dunant Hospital Center,2nd Neurological Department
city: Athens
country: Greece
facility: Aiginitio Hospital, 1st Neurology Clinic
city: Athens
country: Greece
facility: "Hygeia" General Hospital of Athens, Memory clinic
city: Athens
country: Greece
facility: Naval Hospital of Athens
city: Athens
country: Greece
facility: Aiginitio Hospital, 1st Neurology Clinic
city: Chaidari, Athens
country: Greece
facility: University General Hospital of Athens "Attiko"
city: Thessaloniki
country: Greece
facility: AHEPA General University Hospital
city: Thessaloniki
country: Greece
facility: EUROMEDICA General Clinic of Thessaloniki,Neurology Dpt
city: Budapest
country: Hungary
facility: Clinexpert Egészségügyi Szolgáltató és Kereskedelmi Kft.
city: Budapest
country: Hungary
facility: Semmelweis Egyetem ÁOK
city: Debrecen
country: Hungary
facility: DE Kenézy Gyula Campus, Pszichiátriai és Pszichoterápiai Klinika
city: Debrecen
country: Hungary
facility: DE Gyógyszerfejlesztési Koordinációs Központ Pszichiátria
city: Gyor
country: Hungary
facility: Petz Aladar Megyei Korhaz
city: Gyor
country: Hungary
facility: Petz Aladar Megyei Oktato Korhaz
city: Gyöngyös
country: Hungary
facility: Bugát Pál Kórház
city: Kaposvár
country: Hungary
facility: Somogy Megyei Kaposi Mór Oktató Kórház
city: Pécs
country: Hungary
facility: Psychotech Kft.
city: Zalaegerszeg
country: Hungary
facility: Belvárosi Egészségház Kft.
city: Dublin
country: Ireland
facility: St Vincent's University Hospital
city: Dublin
country: Ireland
facility: Mercer's Institute for Successful Aging
city: Dublin
country: Ireland
facility: Tallaght University Hospital
city: Haifa
country: Israel
facility: The Stroke and Cognition Institute Rambam Medical Center
city: Petach Tikva
country: Israel
facility: Cognitive Neurology Clinic, Rabin Campus, Beilinson Hospital
city: Tel Aviv
country: Israel
facility: Cognitive Neurology Sourasky Medical Center
city: Tel Hashomer, Ramat Gan
country: Israel
facility: Chaim Sheba Medical Center, Heart Screening Clinic, 1st floor, Room 317
city: Ancona
country: Italy
facility: AOU Ospedali Riuniti S.O.D
city: Brescia
country: Italy
facility: Azienda Ospedaliera Spedali Civili di Brescia
city: Chieti
country: Italy
facility: Università degli studi Gabriele D'Annunzio Chieti-Pescara
city: Firenze
country: Italy
facility: AOU Careggi Firenze
city: Milano
country: Italy
facility: Fondazione IRCSS Ca' Granda Ospedale Maggiore Policlinico
city: Milano
country: Italy
facility: IRCCS Ospedale San Raffaele Milano
city: Monza
country: Italy
facility: ASST Monza e Brianza Ospedale San Gerardo
city: Perugia
country: Italy
facility: Ospedale Santa Maria della Misericordia
city: Roma
country: Italy
facility: Pol. Uni. Campus Biomedico UOC Neurologia
city: Roma
country: Italy
facility: Policlinico Tor Vergata
city: Roma
country: Italy
facility: Policlinico Universitario A.Gemelli Servizio Neuropsicologia
city: Roma
country: Italy
facility: Fondazione Santa Lucia IRCCS
city: Torino
country: Italy
facility: AOU Città della Salute e della Scienza di Torino
city: Anan, Tokushima
country: Japan
facility: Iwaki Clinic_Psychosomatic medicine
city: Bunkyo-ku, Tokyo
country: Japan
facility: Memory Clinic Ochanomizu
city: Bunkyo-ku,Tokyo
country: Japan
facility: Tokyo Medical And Dental University Hospital
city: Chib-shi, Chiba
country: Japan
facility: Kashiwado Hospital
city: Chofu-shi,Tokyo
country: Japan
facility: Enomoto Internal Medicine Clinic
city: Fujioka-Shi, Gunma
country: Japan
facility: Shinozuka Hospital
city: Hachioji-shi, Tokyo
country: Japan
facility: P-one Clinic
city: Hamamatsu-shi, Shizuoka
country: Japan
facility: National Hospital Organization Tenryu Hospital
city: Himeji-city, Hyogo
country: Japan
facility: Hyogo Brain and Heart Center
city: Himeji-shi, Hyogo
country: Japan
facility: Tsukazaki Hospital
city: Himeji-shi, Hyogo
country: Japan
facility: Himeji Central Hospital Clinic
city: Hirakata-Shi,Osaka
country: Japan
facility: Hatsuta Neurology Clinic
city: Hiroshima-shi, Hiroshima
country: Japan
facility: Imon Yukari Neurology Clinic
city: Hiroshima-shi, Hiroshima
country: Japan
facility: Hikaru-kai Medical Corporation Hiroshima Neurology Clinic
city: Hiroshima-shi, Hiroshima
country: Japan
facility: Hiroshima Neurology Clinic
city: Hofu-shi, Yamaguchi
country: Japan
facility: Nagamitsu Clinic
city: Ina-shi, Nagano
country: Japan
facility: Ina Central Hospital
city: Kanagawa
country: Japan
facility: Kawasaki Saiwai Clinic_Internal Medicine
city: Kawasaki-shi , Kanagawa
country: Japan
facility: Kishiro Mental Clinic
city: Kawasaki-shi, Kanagawa
country: Japan
facility: Koukan Clinic
city: Kawasaki-shi, Kanagawa
country: Japan
facility: Teikyo University Hospital, Mizonokuchi_Kawasaki-shi, Kanagawa
city: Kobe-shi, Hyogo
country: Japan
facility: Kobe University Hospital_Kobe-shi, Hyogo
city: Kodaira-shi, Tokyo
country: Japan
facility: National Center of Neurology and Psychiatry
city: Koriyama-shi, Fukushima
country: Japan
facility: Southern Tohoku Medical Clinic
city: Kurashiki-shi, Okayama
country: Japan
facility: Katayama Medical Clinic
city: Mitaka-shi,Tokyo
country: Japan
facility: Nozomi Memory Clinic
city: Nerima-ku, Tokyo
country: Japan
facility: Kikukawa clinic
city: Niigata-shi, Niigata
country: Japan
facility: General Rehabilitation Center · Midori Hospital
city: Obu-shi, Aichi
country: Japan
facility: National Center for Geriatrics and Gerontology
city: Shimotsuke-shi, Tochigi
country: Japan
facility: Jichiidai Station Brain Clinic
city: Shinjuku-ku, Tokyo
country: Japan
facility: Keio University Hospital
city: Takamatsu-shi, Kagawa
country: Japan
facility: Kagawa Prefectural Central Hospital_Takamatsu-shi, Kagawa
city: Takatsuki-Shi, Osaka
country: Japan
facility: Takatsuki General Hospital
city: Tokorozawa-shi,Saitama
country: Japan
facility: Saino Clinic
city: Tokushima-shi, Tokushima
country: Japan
facility: Itsuki Hospital
city: Tokyo
country: Japan
facility: Alzclinic Tokyo
city: Tokyo
country: Japan
facility: Tokyo Center Clinic
city: Tokyo
country: Japan
facility: Juntendo Tokyo Koto Geriatric Medical Center
city: Tokyo
country: Japan
facility: Kurumi CLINIC
city: Tokyo
country: Japan
facility: Tokyo Medical Univ. Hospital
city: Toride-shi, Ibaraki
country: Japan
facility: Memory Clinic Toride
city: Toyonaka-shi, Osaka
country: Japan
facility: MI Clinic
city: Wako-shi, Saitama
country: Japan
facility: Medical Corporation Midorikai Wako Hospital
city: Busan
country: Korea, Republic of
facility: Dong-A University Medical Center
city: Daejeon
country: Korea, Republic of
facility: Chungnam National University Hospital
city: Gwangju
country: Korea, Republic of
facility: Chonnam National University Hospital
city: Gyeonggi-do
country: Korea, Republic of
facility: Seoul National University Bundang Hospital
city: Incheon
country: Korea, Republic of
facility: Gachon University Gil Medical Center
city: Incheon
country: Korea, Republic of
facility: Inha University Hospital
city: Seoul
country: Korea, Republic of
facility: Hanyang University Medical Center
city: Seoul
country: Korea, Republic of
facility: Hanyang university seoul hospital
city: Seoul
country: Korea, Republic of
facility: Konkuk University Medical Center
city: Seoul
country: Korea, Republic of
facility: Asan Medical Center
city: Seoul
country: Korea, Republic of
facility: Samsung Medical Center_Seoul
city: Seoul
country: Korea, Republic of
facility: Ewha Womans University Seoul Hospital
city: Breda
country: Netherlands
facility: Amphia Ziekenhuis
city: Den Bosch
country: Netherlands
facility: Brain Research Center
city: Nijmegen
country: Netherlands
facility: Radboudumc
city: Kraków
country: Poland
facility: Linden sp. z o.o. sp. k.
state: Małopolskie
city: Bydgoszcz
country: Poland
facility: Centrum Medyczne Neuromed
city: Kielce
country: Poland
facility: Centrum Zdrowia Psychicznego Biomed
city: Kraków
country: Poland
facility: Szpital Uniwersytecki w Krakowie od. Neurologii
city: Kraków
country: Poland
facility: Centrum Neurologii Klinicznej
city: Lublin
country: Poland
facility: Nzoz Neuromed
city: Oswiecim
country: Poland
facility: INSTYTUT ZDROWIA DR BOCZARSKA-JEDYNAKSp. z o.o. Sp. k.
city: Poznan
country: Poland
facility: NZOZ NEURO - KARD Ilkowski i Partnerzy Sp. Part. Lekarzy
city: Scinawa
country: Poland
facility: Osrodek Alzheimerowski Sp. z o.o.
city: Sopot
country: Poland
facility: Centrum Medyczne SENIOR
city: Warszawa
country: Poland
facility: Centrum Medyczne Neuro Protect
city: Wroclaw
country: Poland
facility: NZOZ Wrocławskie Centrum Alzheimerowskie
city: Senhora Da Hora, Matosinhos
country: Portugal
facility: Unidade Local De Saude De Matosinhos E.P.E.
state: Matosinhos
city: Braga
country: Portugal
facility: Hospital de Braga
city: Coimbra
country: Portugal
facility: Unidade Local de Saúde de Coimbra, E.P.E.
city: Guimarães
country: Portugal
facility: Unidade Local de Saude do Alto Ave, E.P.E.
city: Lisboa
country: Portugal
facility: Unidade Local De Saude De Lisboa Ocidental E.P.E. - Hospital Egas Moniz
city: Loures
country: Portugal
facility: Hospital Beatriz Ângelo
city: Porto
country: Portugal
facility: Unidade Local de Saúde de Santo António, E.P.E
city: Torres Vedras
country: Portugal
facility: Campus Neurologico Senior
city: Constanta
country: Romania
facility: Spitalul Clinic Cai Ferate Constanta
city: Constanta
country: Romania
facility: Spitalul Clinic Judetean De Urgenta Sfantul Apostol Andrei Constanta
city: Sibiu
country: Romania
facility: Aria Clinic SRL
city: Ekaterinburg
country: Russian Federation
facility: SAHI SR "Sverdlovsk Regional Clinical Psychiatric Hospital"
city: Ekaterinburg
country: Russian Federation
facility: Joint Stock Company "Medical technologies"
city: Moscow
country: Russian Federation
facility: FSAEI 1st Moscow Federal Med University na Sechenov
city: Moscow
country: Russian Federation
facility: RMAPE
city: Moscow
country: Russian Federation
facility: Pirogov Russian National Research Medical University MoH
city: Omsk
country: Russian Federation
facility: Ezramed Clinic Llc
city: Rostov-on-Don
country: Russian Federation
facility: Research Center for Treatment and Rehabilitation "Phoenix"
city: Saint Petersburg
country: Russian Federation
facility: Psychiatric hospital of st. Nicholas the wonderworker
city: Saint Petersburg
country: Russian Federation
facility: N.-E. State Medical University n.a. Mechnikov
city: Tomsk
country: Russian Federation
facility: Center of Clinica Trials "Nebbiolo"
city: Tomsk
country: Russian Federation
facility: LLC "Clinic Stolet"
city: Ufa
country: Russian Federation
facility: National medical holdiNational medical holding "Medstandard"
city: Belgrade
country: Serbia
facility: Neurology clinic, University Clinical Center of Serbia
city: Kovin
country: Serbia
facility: Special Hospital for Psychiatric Disorders "Kovin"
city: Novi Sad
country: Serbia
facility: University clinical center of Vojvodina, Neurology clinic
city: Bratislava
country: Slovakia
facility: I. neurologicka klinika LF UK a UNB
city: Bratislava
country: Slovakia
facility: Psychiatricka klinika LF UK a UNB
city: Kosice
country: Slovakia
facility: Neurologicka klinika UPJS LF a UNLP
city: Krompachy
country: Slovakia
facility: NEURES, neurologicka ambulancia
city: Vranov nad Toplou
country: Slovakia
facility: Crystal Comfort s.r.o.
city: Ljubljana
country: Slovenia
facility: UKC Ljubljana, Department of Neurology
city: Maribor
country: Slovenia
facility: UKC Maribor - neurology
city: George
country: South Africa
facility: Excellentis Clinical Trial Consultants
state: Eastern Cape
city: Bloemfontein
country: South Africa
facility: IATROS International
state: Free State
city: Johannesburg
country: South Africa
facility: Dr Stanley Lipschitz Clinic Inc
state: Gauteng
city: Pretoria
country: South Africa
facility: Denmar Psychiatric Hospital
state: Gauteng
city: Cape Town
country: South Africa
facility: ACF Neurological service
state: Western Cape
city: Cape Town
country: South Africa
facility: Flexivest Fourteen Research Centre
state: Western Cape
city: Cape Town
country: South Africa
facility: Cape Trial Centre
state: Western Cape
city: Barcelona
country: Spain
facility: Hospital de la Santa Creu i Sant Pau
city: Barcelona
country: Spain
facility: Fundación ACE
city: Madrid
country: Spain
facility: Hospital 12 de Octubre
city: Pozuelo de Alarcon
country: Spain
facility: Hospital Quirón
city: Sant Cugat del Vallès
country: Spain
facility: Hospital Universitari General de Catalunya
city: Valencia
country: Spain
facility: Hospital Universitario Doctor Peset
city: Malmö
country: Sweden
facility: Minnesmottagning specialiserad Malmö
city: Stockholm
country: Sweden
facility: Karolinska Universitetssjukhuset, Huddinge
city: Umeå
country: Sweden
facility: Geriatriskt centrum, Umeå
city: Biel-Bienne
country: Switzerland
facility: Spitalzentrum Biel
city: Genève
country: Switzerland
facility: Centre de la Mémoire
city: Lausanne
country: Switzerland
facility: Centre Leenaards de la mémoire CHUV
city: St. Gallen
country: Switzerland
facility: Klinik für Neurologie Kantonsspital St.Gallen
city: Kaohsiung City
country: Taiwan
facility: Chang Gung Memorial Hospital - Kaoshiung Branch
city: Kaohsiung
country: Taiwan
facility: Kaohsiung Medical University Chung-Ho Memorial Hospital
city: Taichung
country: Taiwan
facility: China Medical University Hospital
city: Tainan City
country: Taiwan
facility: National Cheng Kung University Hospital
city: Taipei
country: Taiwan
facility: National Taiwan University Hospital
city: Taipei
country: Taiwan
facility: Taipei Veteran General Hospital
city: Taoyuan City
country: Taiwan
facility: Chang Gung Memorial Hospital Linkou
city: Altindag/Ankara
country: Turkey
facility: Hacettepe University Medical Faculty Hospital
city: Eskisehir
country: Turkey
facility: Eskisehir Osmangazi University Sağlık Uygulama ve Arastirma
city: Istanbul
country: Turkey
facility: Istanbul University Medical Faculty Neurology Department
city: Izmir
country: Turkey
facility: Izmir Economics University Medical Point Hospital Neurology D
city: Samsun
country: Turkey
facility: Ondokuz Mayis University Saglik Uygulama ve Arastirma Merkez
city: Kharkiv
country: Ukraine
facility: Medical Center 'Neiron'
city: Odesa
country: Ukraine
facility: Odesa Regional Medical Center for Mental Health
city: Cheltenham
country: United Kingdom
facility: Fritchie Centre
state: Gloucestershire
city: Aberdeen
country: United Kingdom
facility: Royal Cornhill Hospital
city: Bath
country: United Kingdom
facility: RICE - The Research Institute for the Care of Older People
city: Crowborough
country: United Kingdom
facility: Dementia Research Unit,
city: Crowborough
country: United Kingdom
facility: Dementia Research Unit
city: Dundee
country: United Kingdom
facility: Ninewells Hospital
city: Edinburgh
country: United Kingdom
facility: Western General Hospital
city: London
country: United Kingdom
facility: St Pancras Clinical Research
city: London
country: United Kingdom
facility: St George's Hospital
city: London
country: United Kingdom
facility: Imperial College London - Imperial College Memory Research Centre
city: Manchester
country: United Kingdom
facility: Greater Manchester Mental Health NHS Foundation Trust
city: Motherwell
country: United Kingdom
facility: NeuroClin
city: Newcastle Upon Tyne
country: United Kingdom
facility: Newcastle University
city: Oxford
country: United Kingdom
facility: Warneford Hospital
city: Southampton
country: United Kingdom
facility: Moorgreen Hospital
city: Swindon
country: United Kingdom
facility: Kings Hill Research Centre
Study officials:
affiliation: Novo Nordisk A/S
name: Clinical Transparency (dept. 2834)
role: STUDY_DIRECTOR
References: