Clinical trial NCT03415607: Comparison on Succinylcholine Onset Time Assessed by Train of Four Stimulation Versus Clinical Judgment During Rapid Sequence Induction of Anesthesia
Official title: Comparison on Succinylcholine Onset Time Assessed by Train of Four Stimulation Versus Clinical Judgment During Rapid Sequence Induction
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Suxamethonium Sensitivity
Aspiration of Gastric Contents Into Respiratory Tract, Part Unspecified
Lead sponsor: University Hospital, Caen
Sponsor class: OTHER
First posted: 2018-01-30
Enrollment: 110
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Every patients undergoing general anesthesia with the use of suxamethonium for induction as assessed by the anesthesiologist

Brief summary: Succinylcholine is a myorelaxant agent often used during rapid sequence induction for patients who need to undergo general anesthesia but who are at risk of pulmonary aspiration of gastric content. Whereas other myorelaxant agents are monitored with train of four stimulation to assess onset and duration, few anesthesiologists use train of four stimulation for onset of succinylcholine, as the anesthesiologists evaluate the effect with the time from injection (usually one minute) and the muscle fasciculation due to the release of acetylcholine.

The data available on onset duration of this drug are old and bases on only few studies, but the succinylcholine if sometime harmful (anaphylaxis , cardiac arrest, bronchospasm).

The investigators want to assess the onset time of succinylcholine with an objective toll , the train of four stimulation, and evaluate if the clinical judgment of the anesthesiologist is reliable to predict an adequate moment for endotracheal intubation.


Eligibility criteria: Inclusion Criteria:

* Every patient undergoing general anesthesia with the use of suxamethonium for induction as assessed by the anesthesiologist

Exclusion Criteria:

* Patient under 18 years old
* Pregnant woman
* Nasotracheal intubation
* Monitoring of train of four at the adductor pollis impossible (such as patient with no arm )

Primary outcomes:
measure: Onset of action of suxamethonium as assessed by the measurement of the train of four stimulation at the adductor pollis
timeFrame: 60 seconds after the injection of suxamethonium
measure: Time from suxamethonium injection to laryngoscopy
timeFrame: 60 seconds after the injection of suxamethonium
Secondary outcomes:
measure: Number of patients whom train of four was not 0 when they benefited from the laryngoscopy
timeFrame: 60 seconds after the injection of suxamethonium
measure: Complications associated with use of suwamethnonium or early laryngoscopy
timeFrame: 60 seconds after the injection of suxamethonium
measure: Main characteristics of the patients and intubation conditions
timeFrame: 60 seconds after the injection of suxamethonium
Other outcomes:
Locations:
city: Caen
country: France
facility: CHU Caen
Study officials:
affiliation: University Hospital, Caen
name: Clément Buléon
role: PRINCIPAL_INVESTIGATOR
References: