Clinical trial NCT05801692: Arterial Blood Gases in Weaning of Mechanical VEntilation
Official title: Arterial Blood Gases in Weaning of Mechanical VEntilation
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Weaning of Mechanical Ventilation
Lead sponsor: Centre Hospitalier Universitaire de Besancon
Sponsor class: OTHER
First posted: 2023-04-06
Enrollment: 100
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Patients hospitalized in intensive care unit with invasive mechanical ventilation, first attempt of weaning of mechnical ventilation

Brief summary: Weaning of mechanical ventilation is an important phase of ICU (Intensive Care Unit) patient hospitalization. Patients have to pass a spontaneous breathing trial, can have a phase of pause with mechanical ventilation before extubation and then can be weaned of invasive mechanical ventilation. Spontaneous breathing trial can be performed with a T-Tube or with Pressure support without PEEP (End Expiratory Positive Pressure) . Duration of spontaneous breathing trial range from 30 minutes to 120 minutes. Some clinicians performed an arterial blood gases at the end of the spontaneous breathing trial but this practice is not really defined and clearly explained in recommendations. Patients can benefit of ventilation support after extubation like non invasive pressure support or high flow nasal canulae. The procedure can be very different from a center to another, especially for arterial blood gases at the end of spontaneous breathing trial. Our aim is to observe in a multicenter study the daily practice of weaning of mechanical ventilation especially for arterial blood gases.


Eligibility criteria: Inclusion Criteria:

* Older than 18 years
* first attempt of weaning of mechanical ventilation

Exclusion Criteria:

* withholding of life sustaining therapies
* spontaneous breathing trial unsuccessful

Primary outcomes:
measure: Type of spontaneous breathing trial performed
timeFrame: In the 24 hours of spontaneous breathing trial
Secondary outcomes:
measure: Arterial blood gases at the end of spontaneous breathing trial
timeFrame: In the hour of spontaneous breathing trial
measure: Duration of spontaneous breathing trial
timeFrame: The day of the spontaneous breathing trial
measure: Ventilatory procedure at the end of spontaneous breathing trial: either immediate extubation or pressure support ventilation with intubation
timeFrame: The day of extubation if extubation performed
measure: Frequency and type of ventilatory support after extubation
timeFrame: The day of extubation if extubation performed
measure: Need for reintubation
timeFrame: During the seven days following extubation
measure: Etiology of reintubation
timeFrame: During the seven days following extubation
measure: Death
timeFrame: The first 28 days following extubation
measure: Ventilator associated pneumoniae
timeFrame: From 48 hours after extubation until extubation
measure: days alive without mechanical ventilation
timeFrame: during the first 28 days of intensive care hospitalization.
Other outcomes:
Locations:
city: Besançon
country: France
facility: BARROT
Study officials:
References: