louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT03044756: Omitting GnRH-antagonist Dose on the Day of Ovulation Trigger
Official title: Impact of Omitting GnR-antagonist on Ovulation Trigger Day in the Fresh Autologous IVF/ICSI Cycles
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: PHASE2
PHASE3
Conditions: Pituitary Downregulation
Keywords: GnRH antagonist
Pituitary downregulation
IVF
ICSI
Lead sponsor: Assiut University
Sponsor class: OTHER
First posted: 2017-02-07
Enrollment: 100
Sex: FEMALE
Minimum age (years): 20
Maximum age (years): 35
Standard ages: ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Intervention model description: Randomized controlled study
Primary purpose: TREATMENT

Brief summary: Omitting the GnRH antagonist on the day of the trigger can be cost effective and more convenient to the women. We will study the impact of omitting the antagonist dose in a prospective randomized trial


Eligibility criteria: Inclusion Criteria:

* All antagonist cycle ivf who agree to participate

Exclusion Criteria:

* expected poor responders.

Primary outcomes:
measure: Number of retrieved oocytes
timeFrame: One Month
Secondary outcomes:
Other outcomes:
Locations:
city: Assiut
country: Egypt
facility: Osama Abdalmageed
state: Non-US/Non-Canadian
city: Assiut
country: Egypt
facility: Osama Abdalmageed
state: Non-US/Non-Canadian
Study officials:
References:
citation: Chang HJ, Lee JR, Jee BC, Suh CS, Lee WD, Kim SH. Cessation of gonadotropin-releasing hormone antagonist on triggering day in flexible multiple-dose protocol: A randomized controlled study. Clin Exp Reprod Med. 2013 Jun;40(2):83-9. doi: 10.5653/cerm.2013.40.2.83. Epub 2013 Jun 30.
Clinical trial NCT02667509: The Evolutionary Model of Mild-to-moderate Myopia in China
Official title: The Evolutionary Model of Mild-to-moderate Myopia in China
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Refractive Error
Keywords: Evolutionary Model
Lead sponsor: Sun Yat-sen University
Sponsor class: OTHER
Collaborators: name: Ministry of Health, China
First posted: 2016-01-29
Enrollment: 852441
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Time perspective: CROSS_SECTIONAL
Sampling method: PROBABILITY_SAMPLE
Study population: Subjects from all the province of China who undergoing the examination of Refractive error from 2005 to 2015 year.

Brief summary: Myopia has emerged as a major health issue in east Asia, because of its increasingly high prevalence in the past few decades (now 80-90% in school-leavers), and because of the sight-threatening pathologies associated with high myopia, which now aff ects 10-20% of those completing secondary schooling in this part of the world. Similar, but less marked, changes are occurring in other parts of the world. The higher prevalence of myopia in east Asian cities seems to be associated with increasing educational pressures, combined with life-style changes, which have reduced the time children spend outside.

Detailed description: Myopia has emerged as a major health issue in east Asia, because of its increasingly high prevalence in the past few decades (now 80-90% in school-leavers), and because of the sight-threatening pathologies associated with high myopia, which now aff ects 10-20% of those completing secondary schooling in this part of the world. Similar, but less marked, changes are occurring in other parts of the world. The higher prevalence of myopia in east Asian cities seems to be associated with increasing educational pressures, combined with life-style changes, which have reduced the time children spend outside.

In this trial, the investigators aim to study the evolutionary model of myopia in China, which could provide new insight into the social development and human adaptation.

Eligibility criteria: Inclusion Criteria:

* Patients complete the examination of Refractive error from 2005 to 2015 year.

Exclusion Criteria:

* Patients could not complete the examination of Refractive error

Primary outcomes:
measure: Refractive error of both eyes measured by autorefractor and subjective measuring
timeFrame: Baseline
Secondary outcomes:
Other outcomes:
Locations:
city: Guangzhou
country: China
facility: Zhongshan Ophthalmic Center, Sun Yat-sen University
state: Guangdong
Study officials:
affiliation: Zhongshan Ophthalmic Center, Sun Yat-sen University
name: Haotian Lin Lin, M.D., Ph.D
role: STUDY_DIRECTOR
affiliation: Zhongshan Ophthalmic Center, Sun Yat-sen University
name: Yizhi Liu, M.D., Ph.D
role: STUDY_CHAIR
affiliation: Zhongshan Ophthalmic Center, Sun Yat-sen University
name: Erping Long, M.D., Ph.D
role: PRINCIPAL_INVESTIGATOR
References:
citation: Morgan IG, Ohno-Matsui K, Saw SM. Myopia. Lancet. 2012 May 5;379(9827):1739-48. doi: 10.1016/S0140-6736(12)60272-4.
Clinical trial NCT05684809: Efficacy of Mobilization With Post- Isometric Relaxation in Neck Pain Associated With Myofascial Trigger Points
Official title: Efficacy of Cervical Mobilization With Post Isometric Relaxation in Managing Mechanical Neck Pain Associated With Myofascial Trigger Points: a Randomized Comparative Study
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Mechanical Neck Pain
Lead sponsor: Najran University
Sponsor class: OTHER
First posted: 2023-01-13
Enrollment: 33
Sex: ALL
Minimum age (years): 20
Maximum age (years): 40
Standard ages: ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: purpose of the study: to determine the effectiveness of cervical mobilization with PIR in reducing pain and improving neck ROM and function in people with mechanical neck pain associated with MTrPs

Detailed description: This study will be based on a randomized controlled design which will be comparative in nature. Participants will be recruited using the convenience sampling method and will be randomly divided into two groups A and B respectively. Thirty participants of mechanical neck pain associated with upper Trapezius trigger point pain will be recruited from the Physiotherapy department, at the Najran University, Saudi Arabia. Study objectives and procedure will be properly explained and written informed consent will be obtained at the beginning of the study. All the participants will be randomly assigned into two equal groups A and B.

Group A will be receiving the hot pack, active Stretching, isometric exercise intervention, and PIR technique while group B will receive the hot pack, active Stretching, isometric exercise intervention, and cervical Mobilization.

Eligibility criteria: Inclusion Criteria:

* age 20-40 years,
* having mechanical neck pain located in the neck or scapular regions along with 1-2 MTrPs which,
* on palpation replicated their chief complaints in the upper Trapezius muscle (unilateral).

Exclusion Criteria:

* known cases of fibromyalgia syndrome,
* cervical radiculopathy or myelopathy,
* history of cervical spine surgery,
* congenital or acquired postural deformity, presence of MTrPs in bilateral upper Trapezius muscles,
* patients who received any treatment for their pain one month prior to the study.

Primary outcomes:
measure: Pain intensity
timeFrame: 3 Weeks
measure: Neck Disability Index
timeFrame: 3 Weeks
measure: Range of Motion
timeFrame: 3 Weeks
measure: Pain Pressure Threshold
timeFrame: 3 Weeks
Secondary outcomes:
Other outcomes:
Locations:
city: Najrān
country: Saudi Arabia
facility: Hashim Ahmed
state: Najran
city: Najrān
country: Saudi Arabia
facility: Hashim Ahmed
state: Najran
Study officials:
affiliation: Najran University
name: Hashim Ahmed, PhD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT01017809: Prolonged Emend in a Study (NYU 03-67) of Oxaliplatin and Topotecan in Previously Treated Ovarian Cancer
Official title: Pilot Study Exploring the Efficacy of Prolonged Emend to Reduce Nausea and Vomiting During Treatment in a Phase II Study (NYU 03-67) of Oxaliplatin Combined With Continuous Infusion Topotecan for Patients With Previously Treated Ovarian Cancer
Study type: INTERVENTIONAL
Overall status: WITHDRAWN
Phase: NA
Conditions: Ovarian Cancer
Keywords: ovarian
chemotherapy
nausea
Lead sponsor: NYU Langone Health
Sponsor class: OTHER
First posted: 2009-11-23
Enrollment: 0
Sex: FEMALE
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: PREVENTION

Brief summary: The investigators propose to totally abolish the emesis (vomiting) associated with the regimen of oxaliplatin + topotecan by adding a daily administration of aprepitant (Emend) for 17 days to the HT3 blocker routinely given on days 1 and 15.

Detailed description: Patients enrolled in NCT0031361, NYU 03-67 (A Phase II study of Oxaliplatin combined with continuous infusion topotecan as chemotherapy for patients with previously treated ovarian cancer NCI #6317) will receive oxaliplatin 85mg/m2 as a 2-hr IV infusion on D1, 15 and topotecan 0.4mg/m2/day as a continuous infusion for 14 days beginning on D1 (D1-15) on a 4 week cycle.

On days 1 and 15 of the first cycle, patients will also receive IV ondansetron 32 mg and 10mg of dexamethasone. Emend 125 mg will be given on day 1; on days 2-17, patients will be given daily oral 80mg Emend without dexamethasone.

On cycles 2-6 patients opting to continue to receive Emend as above: Emend 125 mg will be given on day 1; on days 2-17, patients will be given daily oral 80mg Emend without dexamethasone.

Following cycle 1, Emend will be given in its conventional schedule (i.e., d 1-3, and d 15-17) unless after discussion with the Principal Investigator, the patient's request to receive drug as in cycle 1 is deemed desirable and safe to enter the optional extension arm.

Eligibility criteria: Inclusion Criteria:

* All patients fulfilling the requirement for entering the study NYU 03-67 will be eligible to enter the supplementary protocol with Emend. Please see NCT0031361 for eligibility.

Exclusion Criteria:

* Patients not enrolled on NYU 03-67(NCT0031361).

Primary outcomes:
measure: to determine whether daily administration of Emend will prevent emesis during cycle 1 in patients with previously treated ovarian cancer enrolled in NYU 03-67 (oxaliplatin combined with continuous infusion topotecan)
timeFrame: 28 days (1 cycle)
Secondary outcomes:
Other outcomes:
Locations:
city: New York
country: United States
facility: NYU Clinical Cancer Center
state: New York
Study officials:
affiliation: New York University Cancer Institute
name: Franco Muggia, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT02678585: Nalbuphine as an Adjuvant to Intravenous Regional Anesthesia
Official title: Nalbuphine as an Adjuvant to Intravenous Regional Anesthesia
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Postoperative Pain
Lead sponsor: Assiut University
Sponsor class: OTHER
First posted: 2016-02-10
Enrollment: 106
Sex: ALL
Minimum age (years): 20
Maximum age (years): 50
Standard ages: ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: PREVENTION

Brief summary: The effect of addition of nalbuphine to lidocaine in intravenous regional anesthesia


Eligibility criteria: Inclusion Criteria:

* adult patients
* American Society of Anesthesiologists (ASA) physical status I-II
* age between 20 and 50 years old
* scheduled for elective unilateral short hand surgery

Exclusion Criteria:

* allergy to study medications
* body mass index \> 35 kg/m2
* patients with sickle cell disease or Reynaud disease
* patient refusal

Primary outcomes:
measure: Tourniquet and postoperative pain measured by visual analogue scale
timeFrame: 4 hours
Secondary outcomes:
measure: Cortisol level
timeFrame: 4 hours
Other outcomes:
Locations:
city: Assiut
country: Egypt
facility: Assiut university hospital
Study officials:
References:
Clinical trial NCT02392585: Single or Triple Uterine Tourniquet at Myomectomy
Official title: Triple Tourniquet vs. Single Tourniquet to Reduce Haemorrhage During Myomectomy: a Prospective Randomised Controlled Trial
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Uterine Myoma
Keywords: Leiomyoma of uterus
Hemostasis, Surgical
Prevention of Surgical Blood Loss
mechanical uterine tourniquet
Lead sponsor: Ataturk University
Sponsor class: OTHER
First posted: 2015-03-19
Enrollment: 60
Sex: FEMALE
Minimum age (years): 18
Maximum age (years): 48
Standard ages: ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The aim of study is to compare triple tourniquet vs. single tourniquet to reduce blood loss at open myomectomy.


Eligibility criteria: Inclusion Criteria:

1. Three or more uterine myoma
2. At least one myoma ≥ 8 cm, if there is less than three myoma

Exclusion Criteria:

1. Pedunculated myoma,
2. broad ligament myoma

Primary outcomes:
measure: Estimated blood loss at the end of myomectomy
timeFrame: 15 minutes postoperatively
Secondary outcomes:
measure: The amount of transfusions
timeFrame: 7 Days
measure: A change in hemoglobin
timeFrame: At baseline and 48 hours after surgery
measure: Volume in drains
timeFrame: 7 days
measure: Peri-operative complications
timeFrame: 6 weeks
measure: Total operation time
timeFrame: 5 minutes post operatively
measure: Tourniquet time
timeFrame: 5 minutes after tourniquet removed
Other outcomes:
measure: Anti-Mullerian Hormone levels variation
timeFrame: One year postoperatively
Locations:
city: Erzurum
country: Turkey
facility: Atatürk Üniversitesi Araştırma Hastanesi
Study officials:
affiliation: Ataturk University
name: Neset Gümüsburun, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT00099385: Comprehensive Elementary School Risk Prevention
Official title: Comprehensive Elementary School Risk Prevention
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Risk Behavior
Keywords: social development
risk behaviors
social emotional education
classroom instruction
Lead sponsor: Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Sponsor class: NIH
First posted: 2004-12-14
Enrollment: 2620
Sex: ALL
Minimum age (years): 7
Maximum age (years): 14
Standard ages: CHILD
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: PREVENTION

Brief summary: This project will evaluate the benefit of an enhanced social development program in grades 3-6 to decrease the onset of risky behaviors in pre-adolescents.

Detailed description: Educational programs to promote the adoption of healthy behaviors and to decrease the onset of risky behaviors in pre-adolescents are far more likely to be successful than attempts to alter established patterns of high-risk behaviors. The project involves an evaluation of a comprehensive 4-year elementary school prevention initiative starting in 3rd grade. The prevention initiative, grounded in social cognitive, influence, and development theories is embedded within a pre-existing comprehensive elementary school social development program and will employ an evidence-based social skills curriculum (PATHS) in selected schools. The aim of the program is to teach children to use problem-solving and communication skills to negotiate and prevent high-risk behaviors.

Students attending schools that will receive the enhanced social development program will be compared to students attending schools that will receive the current, standard social development curriculum. The study hypothesizes that students who participate in the 4-year enhanced social development program will self-report fewer risk behaviors when surveyed by the school system in grades 6-8.

Eligibility criteria: Inclusion Criteria:

* All regular education students, including students in bilingual classes

Exclusion Criteria:

- Children attending special education classrooms.

Primary outcomes:
measure: Self reports of risky behaviors
timeFrame: Spring of 2008,2009,2010
Secondary outcomes:
measure: Academic test scores
timeFrame: annually 2006-2008
measure: Measure of social problem solving skills: Social Problem Solving Dilemma
timeFrame: Spring 2007,2008
Other outcomes:
Locations:
city: New Haven
country: United States
facility: Yale University School of Medicine
state: Connecticut
Study officials:
affiliation: Yale University
name: David J Schonfeld, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT04935385: Trace Element During Anesthesia Insertion and Surgery-
Official title: Monitoring Trace Element During Anesthesia Insertion and Surgery- A Prospective, Observational, Cohort Trial
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Trace Elements
Lead sponsor: Rabin Medical Center
Sponsor class: OTHER
First posted: 2021-06-23
Enrollment: 500
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Patients aged 18 and above undergoing elective surgeries (including general surgery, neurosurgery, ear nose and throat surgeries, cardiac surgery, orthopedic surgeries, vascular surgeries and urological surgeries) at Rabin Medical Center under general anesthesia will be eligible for participation.

Brief summary: Trace elements are micronutrients that are of vital important importance to human health and are involved in the process of many key human functions including the immune response, antioxidant defense and wound healing. Deficiency in a single element can manifest with multiple systems and can have significant organ impact.

Research has shown correlation between deficiencies in trace elements and increased risk for infections, sepsis, multi organ failure and mortality. However relatively few studies examined the impact of perioperative changes in trace elements and patients' postoperative outcomes.

In this prospective observational cohort study, we aim to examine the impact of perioperative changes in trace elements on postoperative outcomes, morbidity and mortality.

This study will include patients aged 18 and above undergoing elective surgeries under general anesthesia at Rabin Medical Center. In the operating room blood samples will be collected from all study participants in the beginning of surgery and at the end of surgery.

Collected samples will be sent for analysis of periodic table elements to assess the perioperative period changes in trace elements measured in whole blood. Participants intraoperative and postoperative data will be collected. All postoperative complications will be documented. Perioperative changes will be correlated with participants' postoperative outcomes using computer analytical correlations.


Eligibility criteria: Inclusion Criteria:

* Patients 18 and above
* Patients undergoing elective surgeries (as detailed above) under general anesthesia.
* Patients who can read and write Hebrew

Exclusion Criteria:

1. Emergency surgery
2. Regional anesthesia only

Primary outcomes:
measure: periodic trace elements measured in whole blood before and after surgery under general anesthesia.
timeFrame: 24 hours from surgery
Secondary outcomes:
Other outcomes:
Locations:
city: Petach Tikva
country: Israel
facility: Rabin Medical Center/Beilinson Campus
Study officials:
References:
Clinical trial NCT06967285: Prone Positioning in ARDS: Predicting Neurological Complications Via Cerebral Hemodynamics
Official title: Changes in Cerebral Blood Flow Before and After Prone Position in Patients With ARDS Predict the Occurrence of Neurological Complications
Study type: OBSERVATIONAL
Overall status: RECRUITING
Conditions: ARDS (Moderate or Severe)
Lead sponsor: Sichuan Provincial People's Hospital
Sponsor class: OTHER
First posted: 2025-05-13
Enrollment: 50
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: OTHER
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: Patients with Moderate to Severe ARDS Expected to Undergo Mechanical Ventilation for Over 48 Hours

Brief summary: Prone Positioning in ARDS: Predicting Neurological Complications via Cerebral Hemodynamics

Detailed description: Collecting Medical Records, Demographic Characteristics, and Clinical Data of Moderate to Severe ARDS Patients Requiring Prone Positioning Treatment at Chengdu Pixdu District People's Hospital, Sichuan Provincial People's Hospital, The Fourth People's Hospital of Chengdu, and Chengdu Shuangliu District First People's Hospital from March 2025 to March 2026.

Eligibility criteria: Inclusion Criteria:

* Age≥18 years
* Meet the diagnostic criteria for ARDS(Acute Respiratory Distress Syndrome),with PaO₂/FiO₂\<150 mmHg,and requiring prone ventilation
* Expected duration of mechanical ventilation\>48 hours
* Written informed consent obtained

Exclusion Criteria:

* Presence of contraindications to prone positioning(e.g.,head and neck injuries,spinal instability,severe intracranial hypertension)
* Severe neurological diseases(e.g.,cerebral hemorrhage,cerebral infarction,intracranial space-occupying lesions)that may affect the monitoring of cerebral hemodynamics
* Life-threatening ARDS
* Patients who are unable to undergo neurological assessment
* Poor image quality or absence of images

Primary outcomes:
measure: Neuroimaging Studies
timeFrame: From enrollment to 2 weeks after the end of treatment.
measure: Biomarker Detection
timeFrame: From enrollment to 2 weeks after the end of treatment.
Secondary outcomes:
measure: Incidence rate of delirium
timeFrame: From enrollment to 2 weeks after the end of treatment.
measure: Cognitive function
timeFrame: From enrollment to 2 weeks after the end of treatment.
Other outcomes:
Locations:
city: Chengdu
country: China
facility: Sichuan Provincial People's Hospital,
state: Sichuan
Study officials:
affiliation: Sichuan Provincial People's Hospital
name: lingai Pan, PhD
role: STUDY_CHAIR
References: