louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT06871371: Low and Moderete Flow Anaesthesia on Haemodynamics
Official title: The Comparison of the Effects of Low and Medium Flow Anesthesia on Haemodynamics, Arrhytmia Risk and Cerebral Oxygenation in Laparoscopic Cholecystomy Cases
Study type: INTERVENTIONAL
Overall status: NOT_YET_RECRUITING
Phase: NA
Conditions: Hemodynamics Instability
Arrhythmias Cardiac
Cerebral Oxygenation
Keywords: Low-Medium Flow Anesthesia, Hemodynamics, Oxygenation
Lead sponsor: Umraniye Education and Research Hospital
Sponsor class: OTHER_GOV
First posted: 2025-03-11
Enrollment: 76
Sex: ALL
Minimum age (years): 17
Maximum age (years): 70
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: SCREENING

Brief summary: The study topic investigates the potential advantages of low-flow anesthesia in terms of physiological protection and resource saving.

Detailed description: The study aims to compare the effects of low and normal flow sevoflurane anesthesia on the frontal QRS-T angle and cerebral oxygenation in laparoscopic cholecystectomy surgery. The primary objective was to evaluate the effects of low-flow anesthesia on hemodynamic stability and arrhythmia risk; the secondary objective was to compare the total sevoflurane consumption in both methods.

Eligibility criteria: Inclusion Criteria:

* being ASA1-2 status
* between the ages of 18-70
* who are planned for laparoscopic cholecystectomy

Exclusion Criteria:

* Patients who refuse to give informed consent
* Pregnant and breastfeeding patients
* Morbidly obese patients (Body mass index over 40)
* Patients with uncontrolled diabetes mellitus, with serious cardiovascular, pulmonary, renal, hepatic disease, obstructive sleep apnea, with electrolyte imbalance- Those with a history of alcohol or drug abuse, with perioperative hemodynamic instability
* Patients using drugs known to prolong myocardial repolarization
* inability to increase SPO2 above 95 despite necessary intervention

Primary outcomes:
measure: the effects of low-flow anesthesia on hemodynamic stability
timeFrame: in 2 months
Secondary outcomes:
measure: the cerebral oxygenation
timeFrame: in 2 months
Other outcomes:
Locations:
city: Istanbul
country: Turkey
facility: Umraniye Education and research hospital
Study officials:
affiliation: UMRANIYE E R HOSPITAL
name: SENAY GOKSU, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT00593671: Preimplantation Genetic Screening in Women Over 35 Year
Official title: Preimplantation Genetic Screening for Aneuploidy in Embryos After in Vitro Fertilization in Women Over 35: a Prospective Controlled Randomized Study.
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: In Vitro Fertilization
Keywords: aneuploidies in 7 chromosomes increased with advanced maternal age
Lead sponsor: KU Leuven
Sponsor class: OTHER
First posted: 2008-01-15
Enrollment: 100
Sex: ALL
Minimum age (years): 35
Maximum age (years): 45
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: BASIC_SCIENCE

Brief summary: In view of insufficient evidence to routinely use Preimplantation Genetic Screening (PGS) to improve success rates after IVF, we test the hypothesis that patients with advanced maternal age (AMA) have a higher implantation rate (IR) after embryo transfer (ET) of chromosomally normal embryos following PGS compared to patients who had an ET without PGS.

In a randomized controlled trial (RCT) in patients with AMA (≥ 35 years), the clinical IR per embryo transferred will be compared after ET on day 5 or 6 between the PGS group (embryo biopsy and analysis of chromosomes 13, 16, 18, 21, 22, X and Y) and the control group without PGS.


Eligibility criteria: Inclusion Criteria:

* All couples with a medical indication for IVF and with a female age of at least 35 years are invited to participate in the study.

Exclusion Criteria:

* Cycles were excluded from the study if ≤ 2 fertilized oocytes were available on day 1 after oocyte retrieval (OR), or if ≤ 2 ≥ 6c stage embryos were available on day 3 after OR.

Primary outcomes:
measure: Clinical implantation rate per embryo transferred
timeFrame: end of study
Secondary outcomes:
measure: Pregnancy rate per transfer
timeFrame: end of study
Other outcomes:
Locations:
city: Leuven
country: Belgium
facility: Leuven University Fertility Center
Study officials:
affiliation: UZ Leuven
name: Thomas M D'Hooghe, MD
role: STUDY_DIRECTOR
References:
Clinical trial NCT04704271: Gender Related Differences in the Acute Effects of Delta-9-Tetrahydrocannabinol in Healthy Humans: Sub-Study II
Official title: Gender Related Differences in the Acute Effects of Delta-9-Tetrahydrocannabinol in Healthy Humans: Sub-Study II
Study type: INTERVENTIONAL
Overall status: RECRUITING
Phase: PHASE1
Conditions: Cannabis
Lead sponsor: Yale University
Sponsor class: OTHER
First posted: 2021-01-11
Enrollment: 100
Sex: ALL
Minimum age (years): 18
Maximum age (years): 55
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: CROSSOVER
Primary purpose: BASIC_SCIENCE

Brief summary: The purpose of the study is to characterize the acute effects of cannabinoids in women relative to men and to begin probing the mechanisms that may underlie gender differences.

Detailed description: To characterize the acute effects of vaporized THC in women relative to men and to begin probing the mechanisms that may underlie gender differences.

Eligibility criteria: Inclusion Criteria:

* At least one lifetime exposure to cannabis
* Good physical and mental health

Exclusion Criteria:

* Cannabis naïve individuals
* Major current or recent stressors

Primary outcomes:
measure: Change from Baseline: Rewarding Effects measured by Visual Analog Scale (VAS)
timeFrame: Changes in "high" assessed over the following timepoints: baseline, +60, +80, +120, +180, +300 minutes after start of oral Dronabinol administration.
measure: Change from Baseline: Verbal Learning: Measured by Rey Auditory Verbal Learning Test (RAVLT)
timeFrame: Baseline and +80 minutes after start of oral Dronabinol administration.
Secondary outcomes:
Other outcomes:
Locations:
city: West Haven
country: United States
facility: Biological Studies Unit at the VA Connecticut Healthcare System, Yale School of Medicine
state: Connecticut
Study officials:
References:
Clinical trial NCT05677087: PREPARE: Remote Nutrition Education, Ghana
Official title: PREPARE Project: Examining Impacts of the COVID-19 Pandemic on Maternal Health and Infant and Young Child Feeding Practices
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Health Literacy
Dietary Diversity
Infant Feeding Practices
Lead sponsor: University of Massachusetts, Amherst
Sponsor class: OTHER
Collaborators: name: University of Ghana
First posted: 2023-01-10
Enrollment: 65
Sex: FEMALE
Minimum age (years): 18
Maximum age (years): 49
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: OTHER

Brief summary: In the wake of the pandemic, it is important to explore remote nutrition education programs during the pre- and postnatal period. This is the second phase of a bigger project, where a 6-week intensive remotely delivered nutrition and health education program called the PREPARE program will be piloted. Prepare stands for "Perinatal Remote Education for Pandemic Resilience", and it is a nutrition and health education program meant for pregnant and lactating women aimed at improving maternal and infant dietary diversity, maternal health literacy and increasing COVID-19 awareness. One hundred women will be selected from a pool of 233 women who completed a baseline survey last year. Fifty of them will receive the intervention and the other 50 will receive a delayed intervention.


Eligibility criteria: Inclusion Criteria:

* Women currently enrolled on the preliminary phase of the PREPARE project who participated in our baseline survey are eligible. To have been part of the preliminary survey, women had to have had children between 6 and 15 months old during recruitment last year.
* Due to our primary outcome of infant dietary diversity, women from our preliminary survey whose children are currently between 6 months and 2 years will be included in the PREPARE pilot study.

Exclusion Criteria:

* In our preliminary survey, participants were excluded if they were non-Ghanaian or currently pregnant.
* Besides women who had children less than 6 months at time of recruitment, there will be no other exclusion criteria for the PREPARE pilot.

Primary outcomes:
measure: % infants meeting the Minimum Dietary Diversity (MDD)
timeFrame: 6 weeks
measure: % of Mothers meeting the Minimum Dietary Diversity for women (MDD-W)
timeFrame: 6 weeks
measure: % of mothers scoring >66% on the maternal health literacy inventory in pregnancy (MHELIP) scale.
timeFrame: 6 weeks
Secondary outcomes:
Other outcomes:
Locations:
city: Accra
country: Ghana
facility: University of Ghana
Study officials:
affiliation: University of Massachusetts, Amherst
name: Ruthfirst EA Ayande, MSc
role: PRINCIPAL_INVESTIGATOR
affiliation: University of Massachusetts, Amherst
name: Elena T Carbone, DrPH
role: STUDY_CHAIR
References:
Clinical trial NCT06522087: The Effect of 40 Hz Transcranial Stimulation on the Incidence of Delirium After Total Hip Replacement or Total Knee Replacement Arthroplasty in Elderly Patients.
Official title: The Effect of 40 Hz Transcranial Stimulation on the Incidence of Delirium After Total Hip Replacement or Total Knee Replacement Arthroplasty in Elderly Patients
Study type: INTERVENTIONAL
Overall status: RECRUITING
Phase: NA
Conditions: Postoperative Delirium
Anesthesia
Elderly
Lead sponsor: Henan Provincial People's Hospital
Sponsor class: OTHER
First posted: 2024-07-26
Enrollment: 110
Sex: ALL
Minimum age (years): 65
Maximum age (years): 85
Standard ages: OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: PREVENTION

Brief summary: Delirium is an acute confusional state, it is a sign of acute encephalopathy, also known as acute brain failure, acute brain dysfunction or mental state changes.Postoperative delirium can cause post-traumatic stress disorder, affects patients' quality of life, extend the length of hospital stay, increased hospitalization cost, and is closely relative to short-term and long-term mortality after surgery. Exogenous 40 Hz stimulation can improve cognitive functioning. Therefore, the aim of this study was to investigate the effect of exogenous 40Hz stimulation on the incidence of postoperative delirium in elderly patients undergoing hip and knee replacement.


Eligibility criteria: Inclusion Criteria:

1.65-85 years old, gender not limited 2.General anesthesia unilateral total hip replacement surgery or unilateral total knee replacement 3.ASA classification I-III 4.No drugs for mental and central nervous system diseases were used before surgery 5.Preoperative MMSE score illiterate \> 17 points, primary \> 20 points, junior high school and above \> 24 points 6.Obtaining informed consent

Exclusion Criteria:

1. Severe liver and kidney dysfunction
2. here were mental and nervous system diseases before operation
3. Have a history of alcoholism, long-term use of sedative or analgesic
4. A history of a delirium and other reasons are reluctant to cooperate
5. Massive blood loss and blood transfusion during operation, prolonged operation time

Primary outcomes:
measure: The incidence of postoperative delirium
timeFrame: Day 1, Day 2, Day 3 after surgery
Secondary outcomes:
measure: Blood Markers
timeFrame: Preoperative and postoperative 1 d and 2 d
measure: The incidence of postoperative nausea and vomiting
timeFrame: Day 1, Day 2, Day 3 after surgery
measure: Sleep quality
timeFrame: Day 1, day 2, day 3 after surgery
measure: The incidence of pain
timeFrame: Day 1, day 2, day 3 after surgery
Other outcomes:
Locations:
city: Zhengzhou
country: China
facility: Henan People's Hospital
state: Henan
Study officials:
References:
Clinical trial NCT01273987: Neobladder Posterior Wall Suspended With Round Ligament of Uterus
Official title: Neobladder Posterior Wall Suspended With Round Ligament of Uterus After Radical Cystectomy in Female With Bladder Cancer -a Prospective Control Study
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Female
Bladder Cancer
Radical Cystectomy
Neobladder
Posterior Wall Suspended With Round Ligament of Uterus
Lead sponsor: Southwest Hospital, China
Sponsor class: OTHER
First posted: 2011-01-11
Enrollment: 76
Sex: FEMALE
Minimum age (years): 40
Maximum age (years): 70
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: Objective: to evaluate if the Neobladder posterior wall suspended with round ligament of uterus could improve neobladder empty after radical cystectomy in female patients with bladder cancer compared to present standard neobladder

Detailed description: The investigators developed a technical modification which to aim to provide an posterior support to the ideal neobladder and obtain the anatomy recovered neobladder by posterior wall of neobladder suspended with round ligament. In this study the investigators designed the prospective random trial to evaluate whether this technique improves the neobladder empty compared to a current standard neobladder reconstruction.

Eligibility criteria: Inclusion Criteria:

* The inclusion criteria for the study were bladder cancer (Stage T1G3, T2-3N0-NxM0), female (age between 40 and 70 years old), no history of urethral trauma or urethral stricture; and a desire to obtain an orthotopic neobladder

Exclusion Criteria:

* The exclusion criteria were male sex, posterior urethral margin confirmed as cancer invasive by pathology; and enteritis. The indications and contraindications for orthotopic reconstruction in this study conformed to the criteria set by the guidelines of the European Association of Urology on bladder cancer

Primary outcomes:
measure: postvoiding residual urine (PVP)
timeFrame: 2 years after operation
measure: clean intermittent catheterization(CIC)
timeFrame: 2 years after operation
Secondary outcomes:
measure: rate of complication
timeFrame: through study completion, an average of 2 years
measure: urodynamic profile
timeFrame: 12 months afer operation
measure: rate of continence of neobladder
timeFrame: 12 months after operation
Other outcomes:
Locations:
city: Chongqing
country: China
facility: Urology Institute of PLA, Southwest Hospital
Study officials:
affiliation: Urology Institute of PLA, Southwest Hospital, Chongqin, China
name: ZhiWen Chen, M.D.
role: STUDY_CHAIR
affiliation: Urology Institute of PLA, Southwest Hospital, Chongqin, China
name: HuiXiang Ji, M.D.
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT02304887: The Relationship Between the Residual Renal Function and Osteoporosis Treatment
Official title: The Relationship Between the Residual Renal Function and Osteoporosis Treatment
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Osteoporosis
Keywords: Osteoporosis
Bone mineral densisty
Renal function
CKD-MBD
Lead sponsor: Tomidahama Hospital
Sponsor class: OTHER
First posted: 2014-12-02
Enrollment: 1000
Sex: ALL
Minimum age (years): 45
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: CASE_ONLY
Time perspective: RETROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: Osteoporosis treatment patients

Brief summary: The relationship between osteoporosis drugs and kidney damage is unclear. In this study, we plan to reveal relationship between osteoporosis drugs and kidney damage.

Detailed description: Chronic kidney disease (CKD)- mineral and bone disorder (CKD-MBD) is one of the topic in osteoporosis treatment. As many osteoporotic patients are older, many patients are under the deterioration of the renal function. In addition, several drugs might have the potential for kidney damage. But the relationship between osteoporosis drugs and kidney damage is unclear.

The main objective of this study is to reveal relationship between osteoporosis drugs and kidney damage.

Eligibility criteria: Inclusion Criteria:

* Osteoporosis patients

Exclusion Criteria:

* eGFR \< 15

Primary outcomes:
measure: Longitudinal renal function changes by osteoporotic treatment
timeFrame: Up to 120 months
Secondary outcomes:
Other outcomes:
Locations:
city: Yokkaichi
country: Japan
facility: Tomidahama Hospital
state: Mie
Study officials:
affiliation: Tomidahama Hospital
name: Rui Niimi, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT04939987: Opioid-Free Pain Control Regiment Following Robotic Radical Prostatectomy
Official title: Opioid-Free Pain Control Regiment Following Robotic Radical Prostatectomy: A Randomized Controlled Trial
Study type: INTERVENTIONAL
Overall status: WITHDRAWN
Phase: PHASE2
PHASE3
Conditions: Radical Prostatectomies
Keywords: opioids
postoperative pain
Lead sponsor: Wake Forest University Health Sciences
Sponsor class: OTHER
First posted: 2021-06-25
Enrollment: 0
Sex: MALE
Minimum age (years): 40
Maximum age (years): 75
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: This study will address the gaps in research of non-opioid postoperative pain management for prostatectomies.

Detailed description: This study will conduct a randomized control double-blind clinical trial to evaluate an opioid versus a non-opioid pathway of gabapentin, ketorolac, and acetaminophen in treating postoperative pain following robot-assisted radical prostatectomy (RARP).

Eligibility criteria: Inclusion Criteria:

* All men ages 40-75 undergoing bilateral robot assisted radical prostatectomy (RARP) with bilateral lymph node dissection with low-intermediate to high-risk localized prostate cancer

Exclusion Criteria:

* Allergies to any medication involved in the study
* T4 prostate cancer
* incarcerated persons
* chronic narcotic dependence
* any current prescription for narcotics
* any surgery in the past 6 months

Primary outcomes:
measure: Visual Analogue Pain Score
timeFrame: 1 hour before surgery
measure: Visual Analogue Pain Score
timeFrame: Baseline
measure: Visual Analogue Pain Score
timeFrame: Day 1
measure: Visual Analogue Pain Score
timeFrame: Day 3
measure: Visual Analogue Pain Score
timeFrame: Day 7
measure: Amount of medication used
timeFrame: 1 hour before surgery
measure: Amount of medication used
timeFrame: Baseline
measure: Amount of medication used
timeFrame: Day 1
measure: Amount of medication used
timeFrame: Time of Discharge postoperative up to Day 3
measure: Opioid-Related Symptom Distress Scale (ORSDS)
timeFrame: 1 hour before surgery
measure: Opioid-Related Symptom Distress Scale (ORSDS)
timeFrame: Baseline
measure: Opioid-Related Symptom Distress Scale (ORSDS)
timeFrame: Day 1
measure: Opioid-Related Symptom Distress Scale (ORSDS)
timeFrame: Day 3
measure: Opioid-Related Symptom Distress Scale (ORSDS)
timeFrame: Day 7
Secondary outcomes:
Other outcomes:
Locations:
city: Winston-Salem
country: United States
facility: Wake Forest Health Sciences
state: North Carolina
Study officials:
affiliation: Wake Forest Health Sciences
name: Ram Pathak, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT01673087: Stress Biomarkers:Attaching Biological Meaning to Field Friendly Salivary Measures
Official title: Stress Biomarkers:Attaching Biological Meaning to Field Friendly Salivary Measures
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE1
Conditions: Stress
Keywords: stress biology
cortisol
adrenocorticotropin
salivary biomarkers
Lead sponsor: University of Michigan
Sponsor class: OTHER
First posted: 2012-08-27
Enrollment: 256
Sex: ALL
Minimum age (years): 18
Maximum age (years): 50
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: BASIC_SCIENCE

Brief summary: Cortisol is a stress hormone that can be measured in saliva. This has provided a convenient way to evaluate the biological impact of day-to-day stressors that people encounter as they go about their lives, since saliva is so easy to collect. However, the biological meaning of saliva cortisol measures has never been carefully examined. The goal of this study is to collect saliva from a large group of people as they go about their every-day lives, to measure their cortisol levels, and then study them in the laboratory where Investigators can learn more about how their stress response system (which produces cortisol) is really functioning. Investigators can then determine much more precisely what saliva cortisol levels really mean in terms of stress system biology. This will allow investigators to obtain much more useful information from the next decade of research on naturalistic stress and its biological impact using saliva cortisol measures, helping investigators to understand how stress undermines health and how to combat this effect.


Eligibility criteria: Inclusion Criteria:

* Medically healthy volunteers, ages 18 to 50 years

Exclusion Criteria:

* Pregnancy
* Irregular menses, medications or drugs that effect HPA axis
* Most psychiatric disorders
* Medical problems that effect HPA axis or increase risks involved in participation

Primary outcomes:
measure: cortisol levels
timeFrame: Primarily measuring change from pre-drug baseline to peak occuring about 20 minutes to an hour later
Secondary outcomes:
measure: corticotropin (ACTH)
timeFrame: Primarily measuring change from pre-drug baseline to peak occuring about 10 minutes to an hour later
Other outcomes:
Locations:
city: Ann Arbor
country: United States
facility: University of Michigan Health System
state: Michigan
Study officials:
affiliation: University of Michigan
name: James L Abelson, MD
role: PRINCIPAL_INVESTIGATOR
References: