Clinical trial NCT06689709: Serum Alkaline Phosphatase Levels In Healthy Turkish Children
Official title: Determination Of Serum Alkaline Phosphatase Levels In Healthy Turkish Children
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Alkaline Phosphatase Deficiency
Vitamin D Deficiency
Keywords: Alkaline phosphatase
Vitamin D Deficiency
Lead sponsor: Kecioren Education and Training Hospital
Sponsor class: OTHER
First posted: 2024-11-14
Enrollment: 1000
Sex: ALL
Minimum age (years): 14
Maximum age (years): 18
Standard ages: CHILD
ADULT
Accepts healthy volunteers: yes
Allocation: NA
Intervention model: SINGLE_GROUP
Intervention model description: Prospective study.
Primary purpose: HEALTH_SERVICES_RESEARCH

Brief summary: Alkaline phosphatase (ALP), is a metalloenzyme of the plasma membrane. Serum ALP levels in children are closely related to age and gender, many commercial test kits being used in hospitals, are only offering reference values for adults. The aim of this study is to determine serum ALP levels regarding to age, gender and pubertal stage.

Detailed description: Alkaline phosphatase (ALP), is a metalloenzyme of the plasma membrane. Serum ALP levels in children are closely related to age and gender, many commercial test kits being used in hospitals, are only offering reference values for adults. The aim of this study is to determine serum ALP levels regarding to age, gender and pubertal stage Methods: This stuy has been proceeded on children, who have no history for a chronic diseasse or medication and attending to the Keçiören Education and Research Hospital Pediatric Policlinic for routine control between September 2012-September 2013. In order to determine the serum Alkaline Phosphatase levels in children, 1063 (511 male, 552 female) patients were incorporated. Ca, P and vitamin D levels were also evaluated. The ranges of serum ALP levels in both genders according to age has been determined.

Eligibility criteria: Inclusion Criteria:

* healthy
* Without chronic diseases

Exclusion Criteria:

* With chronic diseases

Primary outcomes:
measure: Serum Alp Levels In Healthy Turkish Children
timeFrame: 1 year
Secondary outcomes:
measure: Vitamin D insufficiency
timeFrame: 1 year
Other outcomes:
Locations:
Study officials:
References:
citation: Abhangi KK, Choudhari SR, Butala PB, Goyal SR, Yadav TG. Salivary Total Protein and Alkaline Phosphatase Activity as Biomarkers for Skeletal Maturity and Growth Prediction in Healthy Children: An In Vivo Study. Int J Clin Pediatr Dent. 2023 Jul-Aug;16(4):603-607. doi: 10.5005/jp-journals-10005-2629.
citation: Lala V, Zubair M, Minter DA. Liver Function Tests. 2023 Jul 30. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan-. Available from http://www.ncbi.nlm.nih.gov/books/NBK482489/
citation: Lu KL, Xie SS, Liu E, Yu XM, Wang L, Yang ZY, Xiong Q, Luo XG, Yang W, Liao W, Zhang YP. Age-wise trends in alkaline phosphatase activity in 167,625 Chinese children aged 0-18 years. Clin Biochem. 2020 May;79:34-40. doi: 10.1016/j.clinbiochem.2020.03.001. Epub 2020 Mar 3.
citation: Topal I, Gumus B. Can Bone-Specific Alkaline Phosphatase and Osteocalcine Levels Be Used to Determine the Age in Children? Am J Forensic Med Pathol. 2020 Sep;41(3):182-187. doi: 10.1097/PAF.0000000000000555.