Clinical trial NCT01818609: Study of Inactivity on Metabolism of Elderly Muscles
Official title: Influence of Reduce Daily Step Count on Muscle Protein Metabolism in Older Persons
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE1
Conditions: Sarcopenia
Keywords: sarcopenia
muscle
reduced activity
insulin sensitivity
protein
step reduction
muscle protein synthesis
whey protein
leg strength
whole body protein
Lead sponsor: McMaster University
Sponsor class: OTHER
First posted: 2013-03-26
Enrollment: 10
Sex: ALL
Minimum age (years): 60
Maximum age (years): 80
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: BASIC_SCIENCE

Brief summary: Skeletal muscle mass declines with inactivity (casting is a good example) and increases with activity (such as weightlifting). Whether muscle mass increases or decreases, is determined by whether more new proteins within muscle are made than are broken down. The investigators know that feeding protein increases the synthesis of new proteins but that the response of older muscles to protein feeding is blunted compared with the young. This resistance of the elderly to muscle building stimuli may be the primary reason that muscle mass is lost in aging. The investigators also know that periods of muscle disuse such as casting result in a person's muscle shrinking due, the investigators believe, to a lower rate of synthesis of new muscle proteins. Age-related muscle loss begins around 50 years old and proceeds at approximately 1% for every year after. Elderly persons would likely fare well with advancing age if their muscle loss were simply linear; however, a rate of muscle loss of 1% annually is a 'population view' and does not represent what occurs during short periods of muscle disuse (i.e. during hospitalization or illness), which occur with increasing frequency in elderly persons. During periods of disuse, the resistance of elderly muscles to protein nutrition may be worsened. The investigators will measure how quickly new proteins are made at rest and after protein feeding in elderly men, before and after a 14 day period of reduced activity brought on by having people reduce their daily step count.


Eligibility criteria: Inclusion Criteria:

* Male or Female
* Aged 60 to 80 years old
* Non-smoker Generally healthy and can tolerate the resistance exercise and protein drink

Exclusion Criteria:

* Allergies to whey protein
* Health problems such as: heart disease, rheumatoid arthritis of the knee joint, diabetes, poor lung function, uncontrolled hypertension, or any health conditions that might put participants at risks for this study
* Failed an exercise stress test
* Taking metformin and/or other medications for the control of blood glucose even though one might not be classified as diabetic
* Taking prescribed blood thinners such as warfarin and heparin but excluding aspirin
* Taking medications for lung and kidney conditions but excluding medication for asthma that is under control

Primary outcomes:
measure: Fractional synthetic rate (FSR) of myofibrillar muscle protein
timeFrame: over 5h
Secondary outcomes:
measure: Blood amino acid concentrations
timeFrame: over 5h
measure: Intramuscular signalling protein status
timeFrame: over 5h
measure: Insulin sensitivity via blood sampling
timeFrame: over 5h
Other outcomes:
Locations:
city: Hamilton
country: Canada
facility: McMaster University
state: Ontario
Study officials:
affiliation: McMaster University
name: Stuart M Phillips, PhD
role: PRINCIPAL_INVESTIGATOR
References: