Clinical trial NCT01094756: Brain, Obesity, Dopamine and You Study
Official title: Central Dopamine Receptors In Obesity
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Obesity
Keywords: Obesity
Lead sponsor: Washington University School of Medicine
Sponsor class: OTHER
Collaborators: name: National Institutes of Health (NIH)
First posted: 2010-03-29
Enrollment: 82
Sex: ALL
Minimum age (years): 18
Maximum age (years): 40
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: NON_RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: Central dopamine is thought to play a significant role in obesity. In support of this idea, animal studies and one human positron emission tomography (PET) study have found reduced postsynaptic D2-like receptor availability in the striatum in obesity, with lower D2 receptor availability associated with higher weight. In addition, reward sensitivity and hedonic responses, known to be related to dopamine function, have also been implicated in obesity and obesity-related eating behavior. These reports have led to the concept that dopaminergic abnormalities (e.g. reduced D2-like receptors) influence reward sensitivity, leading to altered eating behaviors and eventually obesity. However, there are several critical limitations of the human D2 receptor studies that limit the strength of their conclusions and thus the interpretations and speculations embedded in literature that relies on this work. First, estimates of D2-like receptors in humans have been confounded by potential differences in endogenous dopamine release since the PET ligand (raclopride) used is known to be displaceable from receptors by endogenous dopamine. Second, failure to rigorously screen obese individuals for diabetes confounds conclusions, since diabetes has been independently associated with dopaminergic abnormalities such as reduced D2-like receptors and muted dopamine release in diabetic rats. Finally, no human studies have addressed whether reduced D2-like receptor levels are a risk factor for obesity, a consequence of engaging in obesity-related behaviors or being obese or all of the above.


Eligibility criteria: Inclusion Criteria:

* 41 obese adults (BMI 33 kg - 45 kg.)
* 24 lean adults (BMI 18.5 kg - 24.9 kg.)

Exclusion Criteria:

* Subjects who are:

  1. smokers,
  2. pregnant or lactating, postmenopausal,
  3. have diabetes or impaired oral glucose tolerance (fasting blood glucose level of \< 100 mg/dl and a 2 hour post-glucose challenge plasma glucose level of \< 140mg/dl, per ADA criteria; ADA 2004),
  4. significant organ system dysfunction, anemia (Hb \<10 g/dl),
  5. take medications that could influence the study results, any history of dopamine agonist or antagonist treatment (e.g. neuroleptics or metoclopramide),
  6. parkinsonism on exam,
  7. borderline or lower IQ (\<80 full scaled score), or
  8. any psychiatric or neurologic illness (e.g. drug abuse, Parkinson disease, Tourette syndrome, stroke) that could affect the interpretation of the data, compliance or completion of the study will be excluded. Specific psychiatric exclusions are lifetime psychosis, current mania, substance dependence, major depression, social phobia, tic disorders, eating disorders and panic disorder. Dysthymia will not be excluded, but levels of depression will be measured with the BDI for future exploratory analysis.
* Lean subjects will be excluded for being obese in the past (based on maximum BMI not related to pregnancy).

Primary outcomes:
measure: To determine the status of postsynaptic D2-like receptor binding in humans with obesity.
timeFrame: 1 year for each participant
Secondary outcomes:
measure: To determine the relationship between D2-like receptor binding, reward sensitivity and hedonic response to sweet tastes.
timeFrame: 1 year per participant
Other outcomes:
Locations:
city: St. Louis
country: United States
facility: Washington University Medical School
state: Missouri
Study officials:
affiliation: Washington University School of Medicine
name: Tamara Hershey, Ph.D.
role: PRINCIPAL_INVESTIGATOR
References: