Clinical trial NCT05920356: A Study Evaluating Sotorasib Platinum Doublet Combination Versus Pembrolizumab Platinum Doublet Combination as a Front-Line Therapy in Participants With Stage IV or Advanced Stage IIIB/C Nonsquamous Non-Small Cell Lung Cancers (CodeBreaK 202)
Official title: A Phase 3, Multicenter, Randomized, Open-label Study Evaluating Efficacy of Sotorasib Platinum Doublet Combination Versus Pembrolizumab Platinum Doublet Combination as a Front-Line Therapy in Subjects With Stage IV or Advanced Stage IIIB/C Nonsquamous Non-Small Cell Lung Cancers, Negative for PD-L1, and Positive for KRAS p.G12C (CodeBreaK 202)
Study type: INTERVENTIONAL
Overall status: RECRUITING
Phase: PHASE3
Conditions: Non-Small Cell Lung Cancer (NSCLC)
Keywords: Oncology
Lung Cancer
PD-L1
KRAS p.G12C
Sotorasib
Pembrolizumab
Carboplatin
Pemetrexed
CodeBreaK 202
NSCLC
PD-L1 Negative
AMG 510
LUMAKRAS ®
LUMYKRAS ®
Lead sponsor: Amgen
Sponsor class: INDUSTRY
First posted: 2023-06-27
Enrollment: 750
Sex: ALL
Minimum age (years): 18
Maximum age (years): 100
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The primary objective of this study is to compare progression-free survival (PFS) in participants who receive sotorasib with platinum doublet chemotherapy versus participants who receive pembrolizumab with platinum doublet chemotherapy.


Eligibility criteria: Inclusion Criteria:

* Histologically or cytologically confirmed diagnosis of nonsquamous stage IV or advanced Stage IIIB or IIIC NSCLC with KRAS p. G12C mutation and negative for PD-L1 expression by central testing or local laboratory testing confirmed through central testing
* No history of systemic anticancer therapy in metastatic/non-curable settings
* Eastern Cooperative Oncology Group (ECOG) ≤ 1

Exclusion Criteria:

* Mixed histology NSCLC with either small-cell or large-cell neuroendocrine cell component or predominant squamous cell histology
* Participants with tumors known to harbor molecular alterations for which targeted therapy is locally approved
* Symptomatic (treated or untreated) brain metastases
* Gastrointestinal (GI) tract disease causing the inability to take oral medication
* Myocardial infarction within 6 months of randomization, unstable arrhythmias, or unstable angina
* Prior therapy with a KRAS G12C inhibitor

Primary outcomes:
measure: Progression-free Survival (PFS)
timeFrame: From Baseline up to end of study (EOS) (approximately 5.5 years)
Secondary outcomes:
measure: Objective Response Rate (ORR)
timeFrame: From Baseline up to EOS (approximately 5.5 years)
measure: Overall Survival (OS)
timeFrame: From Baseline up to EOS (approximately 5.5 years)
measure: Change in Quality-of-Life Questionnaire Core 30 (QLQ-C30) Dyspnea Domain Score
timeFrame: From Baseline to Week 12
measure: Change in Quality-of-Life Questionnaire Lung Cancer 13 (QLQ-LC13) Symptoms of Dyspnea Subscale
timeFrame: From Baseline to Week 12
measure: Change in QLQ-LC13 Symptoms of Cough Subscale
timeFrame: From Baseline to Week 12
measure: Change in QLQ-LC13 Symptoms of Chest Pain Subscale
timeFrame: From Baseline to Week 12
measure: Change in Physical Function as Measured by QLQ-C30
timeFrame: From Baseline to Week 12
measure: Change in Global Health Status as Measured by QLQ-C30
timeFrame: From Baseline to Week 12
measure: Progression-free Survival 2 (PFS2)
timeFrame: From Baseline up to EOS (approximately 5.5 years)
measure: Change in QLQ-LC13 Subscale Scores
timeFrame: From Baseline up to EOS (approximately 5.5 years)
measure: Change in QLQ-C30 Subscale Scores
timeFrame: From Baseline up to EOS (approximately 5.5 years)
measure: Time to Deterioration in QLC-LC13 Subscale Scores
timeFrame: From Baseline to Week 12
measure: Time to Deterioration in QLC-C30 Subscale Scores
timeFrame: From Baseline to Week 12
measure: Change in Summary Scores and Visual Analogue Scale (VAS) Scores
timeFrame: From Baseline up to EOS (approximately 5.5 years)
measure: Duration of Response
timeFrame: From Baseline up to EOS (approximately 5.5 years)
measure: Time to Response
timeFrame: From Baseline up to EOS (approximately 5.5 years)
measure: Disease Control
timeFrame: From Baseline up to EOS (approximately 5.5 years)
measure: PFS
timeFrame: From Baseline up to EOS (approximately 5.5 years)
measure: Objective Response
timeFrame: From Baseline up to EOS (approximately 5.5 years)
measure: Number of Participants With Treatment-Emergent Adverse Events
timeFrame: From Baseline up to EOS (approximately 5.5 years)
measure: Number of Participants With Clinically Significant Changes in Vital Signs
timeFrame: From Baseline up to EOS (approximately 5.5 years)
measure: Number of Participants With Clinically Significant Changes in Clinical Laboratory Tests
timeFrame: From Baseline up to EOS (approximately 5.5 years)
measure: Maximum Plasma Concentration (Cmax) of Sotorasib
timeFrame: Pre-dose Day 1 up to Day 64
measure: Minimum Plasma Concentration (Cmin) of Sotorasib
timeFrame: Pre-dose Day 1 up to Day 64
measure: Area Under The Curve (AUC) of Sotorasib
timeFrame: Pre-dose Day 1 up to Day 64
Other outcomes:
Locations:
city: Santa Barbara
country: United States
facility: Sansum Clinic
state: California
city: Newark
country: United States
facility: Medical Oncology Hematology Consultants Helen F Graham Cancer Center
state: Delaware
city: Chicago
country: United States
facility: University of Illinois Chicago
state: Illinois
city: Niles
country: United States
facility: Illinois Cancer Specialists
state: Illinois
city: Louisville
country: United States
facility: Norton Cancer Institute - Brownsboro
state: Kentucky
city: Worcester
country: United States
facility: Reliant Medical Group Inc
state: Massachusetts
city: Albuquerque
country: United States
facility: University of New Mexico Cancer Center
state: New Mexico
city: New York
country: United States
facility: Memorial Sloan Kettering Cancer Center
state: New York
city: Durham
country: United States
facility: Duke University
state: North Carolina
city: Pinehurst
country: United States
facility: FirstHealth Cancer Center
state: North Carolina
city: Media
country: United States
facility: Alliance Cancer Specialists - Media
state: Pennsylvania
city: Pittsburgh
country: United States
facility: University of Pittsburgh Medical Center
state: Pennsylvania
city: Knoxville
country: United States
facility: University of Tennessee Medical Center Knoxville
state: Tennessee
city: Nashville
country: United States
facility: Sarah Cannon Research Institute
state: Tennessee
city: Nashville
country: United States
facility: United States Oncology Regulatory Affairs Corporate Office
state: Tennessee
city: Houston
country: United States
facility: University of Texas MD Anderson Cancer Center
state: Texas
city: Irving
country: United States
facility: US Oncology Research Investigational Products Center
state: Texas
city: Caba
country: Argentina
facility: Hospital Britanico de Buenos Aires
state: Buenos Aires
city: Capital Federal
country: Argentina
facility: Instituto Alexander Fleming
state: Buenos Aires
city: Ciudad Autónoma de Buenos Aires
country: Argentina
facility: Instituto Argentino de Diagnostico y Tratamiento IADT
state: Buenos Aires
city: La Plata
country: Argentina
facility: Hospital Italiano de La Plata
state: Buenos Aires
city: San Salvador de Jujuy
country: Argentina
facility: Fundacion Ars Medica
state: Jujuy
city: Viedma
country: Argentina
facility: Clinica Viedma
state: Río Negro
city: Rosario
country: Argentina
facility: Sanatorio Parque SA
state: Santa Fe
city: Buenos Aires
country: Argentina
facility: Centro Oncologico Korben
city: La Rioja
country: Argentina
facility: Fundacion Centro Oncológico Riojano Integral para la Investigación y Prevención del Cáncer
city: Salta
country: Argentina
facility: Centro de Diagnostico Investigacion y Tratamiento
city: Campbelltown
country: Australia
facility: Campbelltown Hospital
state: New South Wales
city: Concord
country: Australia
facility: Concord Repatriation General Hospital
state: New South Wales
city: Kingswood
country: Australia
facility: Nepean Cancer Centre
state: New South Wales
city: St Leonards
country: Australia
facility: GenesisCare -North Shore Oncology
state: New South Wales
city: Waratah
country: Australia
facility: Calvary Mater Newcastle Hospital
state: New South Wales
city: Toowoomba
country: Australia
facility: Toowoomba Hospital
state: Queensland
city: Woolloongabba
country: Australia
facility: Princess Alexandra Hospital
state: Queensland
city: Adelaide
country: Australia
facility: Cancer Research South Australia
state: South Australia
city: Melbourne
country: Australia
facility: Peter MacCallum Cancer Centre
state: Victoria
city: Melbourne
country: Australia
facility: The Alfred Hospital
state: Victoria
city: Graz
country: Austria
facility: Medizinische Universitaet Graz
city: Klagenfurt
country: Austria
facility: Klinikum Klagenfurt am Woerthersee
city: Krems
country: Austria
facility: Universitaetsklinikum Krems
city: Salzburg
country: Austria
facility: Landeskrankenhaus Salzburg
city: Wels
country: Austria
facility: Klinikum Wels - Grieskirchen GmbH
city: Auderghem
country: Belgium
facility: Chirec - Delta Ziekenhuis
city: Gent
country: Belgium
facility: Algemeen Ziekenhuis Maria Middelares
city: Leuven
country: Belgium
facility: Universitair Ziekenhuis Leuven - Campus Gasthuisberg
city: Liège
country: Belgium
facility: Centre Hospitalier Regional de la Citadelle
city: Mechelen
country: Belgium
facility: Algemeen Ziekenhuis Sint-Maarten
city: Salvador
country: Brazil
facility: Núcleo de Oncologia da Bahia
state: Bahia
city: Brasilia
country: Brazil
facility: Hospital Sirio Libanes
state: Distrito Federal
city: Brasilia
country: Brazil
facility: Oncoclinicas Onco Vida Distrito Federal
state: Distrito Federal
city: Cachoeiro de Itapemirim
country: Brazil
facility: Hospital Evangelico de Cachoeiro de Itapemirim
state: Espírito Santo
city: Belo Horizonte
country: Brazil
facility: Nucleo de Ensino Pesquisa e Inovacao Mario Penna
state: Minas Gerais
city: Belem
country: Brazil
facility: Centro de Tratamento Oncologico - Cto
state: Pará
city: Recife
country: Brazil
facility: Instituto de Medicina Integral Professor Fernando Figueira - Imip
state: Pernambuco
city: Natal
country: Brazil
facility: Liga Norte-Riograndense Contra O Cancer
state: Rio Grande Do Norte
city: Canoas
country: Brazil
facility: Associação Beneficente de Canoas
state: Rio Grande Do Sul
city: Porto Alegre
country: Brazil
facility: Irmandade da Santa Casa de Misericordia de Porto Alegre
state: Rio Grande Do Sul
city: Porto Alegre
country: Brazil
facility: Hospital Sao Lucas da Pontificia Universidade Catolica do Rio Grande do Sul
state: Rio Grande Do Sul
city: Santa Cruz do Sul
country: Brazil
facility: Centro de pesquisa em oncologia Hospital Ana Nery
state: Rio Grande Do Sul
city: Itajai
country: Brazil
facility: Clinica de Neoplasias Litoral
state: Santa Catarina
city: Barretos
country: Brazil
facility: Fundacao Pio 12 Hospital de Amor de Barretos
state: São Paulo
city: Santos
country: Brazil
facility: Santa Casa de Misericordia de Santos - Iscms
state: São Paulo
city: Sao Paulo
country: Brazil
facility: Beneficencia Portuguesa de Sao Paulo - Bp
state: São Paulo
city: Sao Paulo
country: Brazil
facility: Fundacao Antonio Prudente
state: São Paulo
city: São José do Rio Preto
country: Brazil
facility: Hospital de Base de Sao Jose do Rio Preto
state: São Paulo
city: Rio de Janeiro
country: Brazil
facility: Oncoclinicas Rio de Janeiro S A
city: São Paulo
country: Brazil
facility: Instituto de Ensino e Pesquisa Sao Lucas Iep Sao Lucas
city: São Paulo
country: Brazil
facility: Instituto do Cancer do Estado de Sao Paulo Octavio Frias de Oliveira Icesp
city: Panagyurishte
country: Bulgaria
facility: Multiprofile Hospital for Active Treatment - Uni Hospital OOD
city: Pleven
country: Bulgaria
facility: University Multiprofile Hospital for Active Treatment Sveta Marina - Pleven OOD
city: Sofia
country: Bulgaria
facility: Multiprofile Hospital for Active Treatment for Womens Health - Nadezhda OOD
city: Sofia
country: Bulgaria
facility: Acibadem City Clinic University Multiprofile Hospital for Active Treatment Tokuda EAD
city: Sofia
country: Bulgaria
facility: University Multiprofile Hospital for Active Treatment Tsaritsa Yoanna - ISUL EAD
city: Halifax
country: Canada
facility: Queen Elizabeth II, Health Sciences Centre
state: Nova Scotia
city: Toronto
country: Canada
facility: Sunnybrook Research Institute Sunnybrook Health Sciences Centre
state: Ontario
city: Montreal
country: Canada
facility: McGill University Health Centre Glen Site
state: Quebec
city: Montreal
country: Canada
facility: CIUSSS - du Nord-de-lIle-de-Montreal / Hopital Sacre-Coeur de Montreal
state: Quebec
city: Quebec City
country: Canada
facility: Institut Universitaire de cardiologie et de pneumologie de Quebec
state: Quebec
city: Regina
country: Canada
facility: Allan Blair Cancer Centre
state: Saskatchewan
city: Saskatoon
country: Canada
facility: Saskatoon Cancer Centre
state: Saskatchewan
city: Temuco
country: Chile
facility: James Lind Centro de Investigacion del Cancer
state: Cautín
city: Temuco
country: Chile
facility: Clinica CIDO
state: Cautín
city: Santiago
country: Chile
facility: Orlandi Oncologia
city: Santiago
country: Chile
facility: Fundacion Arturo Lopez Perez
city: Santiago
country: Chile
facility: Biocinetic servicios medicos limitada
city: Talca
country: Chile
facility: Centro de Investigacion del Maule
city: Bengbu
country: China
facility: The First Affiliated Hospital of Bengbu Medical University
state: Anhui
city: Hefei
country: China
facility: Anhui Chest Hospital
state: Anhui
city: Beijing
country: China
facility: Peking Union Medical College Hospital
state: Beijing
city: Chongqing
country: China
facility: Chongqing University Cancer Hospital
state: Chongqing
city: Fuzhou
country: China
facility: Fujian Provincial Hospital
state: Fujian
city: Fuzhou
country: China
facility: Fujian Cancer Hospital
state: Fujian
city: Fuzhou
country: China
facility: Fujian Medical University Union Hospital
state: Fujian
city: Xiamen
country: China
facility: The First Affiliated Hospital of Xiamen University
state: Fujian
city: Xiamen
country: China
facility: Zhongshan Hospital Xiamen University
state: Fujian
city: Lanzhou
country: China
facility: Gansu Province Cancer Hospital
state: Gansu
city: Guangzhou
country: China
facility: Guangdong Provincial Peoples Hospital
state: Guangdong
city: Guangzhou
country: China
facility: Affiliated Cancer Hospital and institute of Guangzhou Medical University
state: Guangdong
city: Shantou
country: China
facility: Cancer Hospital of Shantou University Medical College
state: Guangdong
city: Liuzhou
country: China
facility: Liuzhou Peoples Hospital
state: Guangxi
city: Nanning
country: China
facility: Guangxi Medical University Cancer Hospital
state: Guangxi
city: Haikou
country: China
facility: Hainan Cancer Hospital
state: Hainan
city: Baoding
country: China
facility: Affiliated Hospital of Hebei University
state: Hebei
city: Harbin
country: China
facility: Harbin Medical University Cancer Hospital
state: Heilongjiang
city: Anyang
country: China
facility: AnYang Tumor Hospital
state: Henan
city: Luoyang
country: China
facility: The First Affiliated Hospital of Henan University of Science And Technology
state: Henan
city: Zhengzhou
country: China
facility: Henan Cancer Hospital
state: Henan
city: Zhengzhou
country: China
facility: The First Affiliated Hospital of Zhengzhou University
state: Henan
city: Wuhan
country: China
facility: Union Hospital Tongji Medical College Huazhong University of Science and Technology
state: Hubei
city: Wuhan
country: China
facility: Tongji Hospital Tongji Medical College Of Hust
state: Hubei
city: Xiangyang
country: China
facility: Xiangyang Central Hospital
state: Hubei
city: Changsha
country: China
facility: Xiangya Hospital Central South University
state: Hunan
city: Changsha
country: China
facility: The Second Xiangya Hospital of Central South University
state: Hunan
city: Changsha
country: China
facility: Hunan Cancer Hospital
state: Hunan
city: Changsha
country: China
facility: Hunan Cancer Hospital
state: Hunan
city: Nanjing
country: China
facility: Nanjing Drum Tower Hospital
state: Jiangsu
city: Nanjing
country: China
facility: Nanjing First Hospital
state: Jiangsu
city: Nanchang
country: China
facility: The First Affiliated Hospital of Nanchang University
state: Jiangxi
city: Nanchang
country: China
facility: Jiangxi Cancer Hospital
state: Jiangxi
city: Changchun
country: China
facility: Jilin Cancer Hospital
state: Jilin
city: Jinan
country: China
facility: Cancer Hospital of Shandong First Medical University
state: Shandong
city: Linyi
country: China
facility: Linyi Peoples Hospital
state: Shandong
city: Weifang
country: China
facility: Weifang Peoples Hospital
state: Shandong
city: Shanghai
country: China
facility: Fudan University Shanghai Cancer Center
state: Shanghai
city: Taiyuan
country: China
facility: Shanxi Cancer Hospital
state: Shanxi
city: Xi'an
country: China
facility: The First Affiliated Hospital of Xi An JiaoTong University
state: Shanxi
city: Chengdu
country: China
facility: Sichuan Cancer Hospital
state: Sichuan
city: Chengdu
country: China
facility: West China Hospital of Sichuan University
state: Sichuan
city: Tianjin
country: China
facility: Tianjin Medical University Cancer Institute and Hospital
state: Tianjin
city: Kunming
country: China
facility: Yunnan Cancer Hospital
state: Yunnan
city: Hangzhou
country: China
facility: the First Affiliated Hospital Zhejiang University School of Medicine
state: Zhejiang
city: Hangzhou
country: China
facility: Zhejiang Cancer Hospital
state: Zhejiang
city: Hangzhou
country: China
facility: Sir Run Run Shaw Hospital Affiliated to Zhejiang University School of Medicine
state: Zhejiang
city: Nantong
country: China
facility: Nantong Tumor Hospital
state: Zhejiang
city: Taizhou
country: China
facility: Taizhou Hospital of Zhejiang Province
state: Zhejiang
city: Beijing
country: China
facility: Beijing Cancer Hospital
city: Beijing
country: China
facility: Beijing Chest Hospital, Capital Medical University
city: Medellin
country: Colombia
facility: Fundacion Colombiana de Cancerologia Clinica Vida
state: Antioquia
city: Valledupar
country: Colombia
facility: Sociedad de Oncologia y Hematologia del Cesar
state: Cesar
city: Bogota
country: Colombia
facility: Instituto Nacional de Cancerologia
state: Cundinamarca
city: Bogotá
country: Colombia
facility: Centro de Tratamiento e Investigación sobre Cancer Luis Carlos Sarmiento Angulo Ctic
state: Cundinamarca
city: Monteria
country: Colombia
facility: Instituto Medico de Alta Tecnologia sas - Imat sas
state: Córdoba
city: Pereira
country: Colombia
facility: Oncologos del Occidente SAS
state: Risaralda
city: Bucaramanga
country: Colombia
facility: Fundacion cardiovascular de Colombia
state: Santander
city: Barranquilla
country: Colombia
facility: Centro Cancerologico del Caribe LTDA CECAC
city: Brno
country: Czechia
facility: Fakultni nemocnice Brno
city: Olomouc
country: Czechia
facility: Fakultni nemocnice Olomouc
city: Plzen
country: Czechia
facility: Fakultni nemocnice Plzen
city: Aarhus N
country: Denmark
facility: Aarhus Universitetshospital
city: Copenhagen
country: Denmark
facility: Rigshospitalet
city: Herning
country: Denmark
facility: Regionshospitalet Godstrup
city: Sonderborg
country: Denmark
facility: Sonderborg Sygehus
city: Vejle
country: Denmark
facility: Vejle Sygehus
city: Besancon
country: France
facility: Centre Hospitalier Regional Universitaire de Besancon - Hopital Jean Minjoz
city: Boulogne-Billancourt
country: France
facility: Centre Hospitalier Universitaire Ambroise Pare
city: Caen
country: France
facility: Centre Hospitalier Universitaire de Caen - Hopital Cote de Nacre
city: Creteil
country: France
facility: Centre Hospitalier Intercommunal de Creteil
city: La Roche sur Yon
country: France
facility: Centre Hospitalier Departemental Les Oudairies
city: Le Mans
country: France
facility: Centre Hospitalier - Le Mans
city: Lille Cedex
country: France
facility: Centre Hospitalier Régional Universitaire de Lille - Institut Coeur Poumon
city: Marseille Cedex 20
country: France
facility: Centre Hospitalier Universitaire Nord
city: Montpellier
country: France
facility: Centre de Cancerologie du Grand Montpellier-Clinique Clementville
city: Nantes Cedex 2
country: France
facility: Hopital prive du Confluent
city: Nice
country: France
facility: Centre Antoine Lacassagne
city: Nimes cedex 9
country: France
facility: Hopital Universitaire Caremeau
city: Paris Cedex 20
country: France
facility: Hopital Tenon
city: Paris
country: France
facility: Institut Curie
city: Paris
country: France
facility: Groupe Hospitalier Paris Saint Joseph
city: Paris
country: France
facility: Hopital Cochin
city: Pessac Cedex
country: France
facility: Centre Hospitalier Universitaire de Bordeaux - Hopital Haut Leveque
city: Poitiers CEDEX
country: France
facility: Centre Hospitalier Universitaire de Poitiers - Hopital la Miletrie
city: Quimper
country: France
facility: Centre Hospitalier de Cornouaille
city: Reims Cedex
country: France
facility: Centre Hospitalier Universitaire de Reims - Hopital Christian Cabrol
city: Rennes
country: France
facility: Centre Hospitalier Universitaire de Rennes - Hopital Pontchaillou
city: Rouen Cedex
country: France
facility: Centre Hospitalier Universitaire de Rouen - Hopital Charles Nicolle
city: Saint Priest en Jarez
country: France
facility: Centre Hospitalier Universitaire de Saint Etienne - Hopital Nord
city: Strasbourg Cedex
country: France
facility: Centre Hospitalier Universitaire de Strasbourg - Nouvel Hopital Civil
city: Toulon
country: France
facility: Hopital d instruction des armees sainte anne
city: Toulouse Cedex 9
country: France
facility: Centre Hospitalier Universitaire de Toulouse - Hopital Larrey
city: Tours Cedex 9
country: France
facility: Centre Hospitalier Regional Universitaire de Tours - Hopital Bretonneau
city: Villefranche Sur Saone Cedex
country: France
facility: Hopital Nord Ouest Villefranche sur Saone
city: Villejuif
country: France
facility: Gustave Roussy
city: Chemnitz
country: Germany
facility: Klinikum Chemnitz GmbH
city: Gauting
country: Germany
facility: Asklepios Fachkliniken Muenchen Gauting
city: Goettingen
country: Germany
facility: Universitaetsmedizin Goettingen
city: Kempten
country: Germany
facility: Klinikverbund Allgaeu
city: Muenchen
country: Germany
facility: Klinikum der LMU Muenchen
city: Athens
country: Greece
facility: 251 General Airforce Hospital
city: Athens
country: Greece
facility: Henry Dunant Hospital Center
city: Athens
country: Greece
facility: Alexandra Hospital
city: Athens
country: Greece
facility: Attikon University Hospital
city: Athens
country: Greece
facility: Iaso Hospital
city: Athens
country: Greece
facility: Metropolitan Hospital
city: Marousi
country: Greece
facility: Iaso General Clinic
city: Piraeus
country: Greece
facility: Metaxa Anticancer Hospital
city: Thessaloniki
country: Greece
facility: Theagenion Cancer Hospital
city: Thessaloniki
country: Greece
facility: Agios Loukas Clinic
city: Thessaloniki
country: Greece
facility: European Interbalkan Medical Center
city: Hong Kong
country: Hong Kong
facility: Queen Mary Hospital, The University of Hong Kong
city: Kowloon
country: Hong Kong
facility: Princess Margaret Hospital
city: Kowloon
country: Hong Kong
facility: Queen Elizabeth Hospital, Hong Kong
city: Budapest
country: Hungary
facility: Orszagos Koranyi Pulmonologiai Intezet
city: Budapest
country: Hungary
facility: Budapesti Uzsoki Utcai Korhaz
city: Farkasgyepu
country: Hungary
facility: Farkasgyepui Tudogyogyintezet
city: Gyongyos
country: Hungary
facility: Matrai Gyogyintezet
city: Gyor
country: Hungary
facility: Gyor-Moson-Sopron Varmegyei Petz Aladar Egyetemi Oktatokorhaz
city: Szekesfehervar
country: Hungary
facility: Fejer Varmegyei Szent Gyorgy Egyetemi Oktato Korhaz
city: Szolnok
country: Hungary
facility: Jasz-Nagykun-Szolnok Varmegyei Hetenyi Geza Korhaz-Rendelointezet
city: Tatabanya
country: Hungary
facility: Komarom-Esztergom Varmegyei Szent Borbala Korhaz
city: Torokbalint
country: Hungary
facility: Reformatus Pulmonologiai Centrum
city: Bari
country: Italy
facility: IRCCS Istituto Tumori Giovanni Paolo II
city: Catania
country: Italy
facility: Azienda Ospedaliero Universitaria Policlinico G Rodolico - San Marco Presidio Ospedaliero G Rodolico
city: Firenze
country: Italy
facility: Azienda Ospedaliero Universitaria Careggi
city: Meldola (FC)
country: Italy
facility: Istituto Romagnolo per lo Studio dei Tumori Dino Amadori
city: Milano
country: Italy
facility: Fondazione IRCCS Istituto Nazionale dei Tumori
city: Monza (MB)
country: Italy
facility: Fondazione IRCCS San Gerardo dei Tintori
city: Napoli
country: Italy
facility: Azienda Ospedaliera di Rilievo Nazionale Specialistica dei Colli Monaldi
city: Napoli
country: Italy
facility: Azienda Ospedaliero Universitaria Luigi Vanvitelli
city: Parma
country: Italy
facility: Azienda Ospedaliero-Universitaria di Parma
city: Perugia
country: Italy
facility: Azienda Ospedaliera di Perugia Ospedale Santa Maria della Misericordia
city: Pesaro
country: Italy
facility: Azienda Sanitaria Territoriale Pesaro Urbino - Presidio San Salvatore Muraglia
city: Rome
country: Italy
facility: IRCCS Istituti Fisioterapici Ospitalieri
city: Nagoya-shi
country: Japan
facility: Nagoya University Hospital
state: Aichi
city: Hirosaki-shi
country: Japan
facility: Hirosaki University Hospital
state: Aomori
city: Chiba-shi
country: Japan
facility: Chiba Cancer Center
state: Chiba
city: Kashiwa-shi
country: Japan
facility: National Cancer Center Hospital East
state: Chiba
city: Matsuyama-shi
country: Japan
facility: National Hospital Organization Shikoku Cancer Center
state: Ehime
city: Toon-shi
country: Japan
facility: Ehime University Hospital
state: Ehime
city: Fukuoka-shi
country: Japan
facility: National Hospital Organization Kyushu Cancer Center
state: Fukuoka
city: Kitakyushu-shi
country: Japan
facility: Hospital of the University of Occupational and Environmental Health, Japan
state: Fukuoka
city: Kurume-shi
country: Japan
facility: Kurume University Hospital
state: Fukuoka
city: Fukuyama-shi
country: Japan
facility: Chugoku Central Hospital of Japan Mutual Aid Association of Public School Teachers
state: Hiroshima
city: Sapporo-shi
country: Japan
facility: National Hospital Organization Hokkaido Cancer Center
state: Hokkaido
city: Kobe-shi
country: Japan
facility: Kobe Minimally invasive Cancer Center
state: Hyogo
city: Takarazuka-shi
country: Japan
facility: Takarazuka City Hospital
state: Hyogo
city: Kanazawa-shi
country: Japan
facility: Kanazawa University Hospital
state: Ishikawa
city: Kawasaki-shi
country: Japan
facility: St Marianna University Hospital
state: Kanagawa
city: Yokohama-shi
country: Japan
facility: Kanagawa Prefectural Hospital Organization Kanagawa Cancer Center
state: Kanagawa
city: Kyoto-shi
country: Japan
facility: Kyoto University Hospital
state: Kyoto
city: Natori-shi
country: Japan
facility: Miyagi Cancer Center
state: Miyagi
city: Sendai-shi
country: Japan
facility: Sendai Kousei Hospital
state: Miyagi
city: Niigata-shi
country: Japan
facility: Niigata Cancer Center Hospital
state: Niigata
city: Okayama-shi
country: Japan
facility: Okayama University Hospital
state: Okayama
city: Hirakata-shi
country: Japan
facility: Kansai Medical University Hospital
state: Osaka
city: Osaka-shi
country: Japan
facility: Osaka International Cancer Institute
state: Osaka
city: Osakasayama-shi
country: Japan
facility: Kindai University Hospital
state: Osaka
city: Sakai-shi
country: Japan
facility: National Hospital Organization Kinki-chuo Chest Medical Center
state: Osaka
city: Kitaadachi-gun
country: Japan
facility: Saitama Cancer Center
state: Saitama
city: Sunto-gun
country: Japan
facility: Shizuoka Cancer Center
state: Shizuoka
city: Bunkyo-ku
country: Japan
facility: Juntendo University Hospital
state: Tokyo
city: Koto-ku
country: Japan
facility: The Cancer Institute Hospital of Japanese Foundation for Cancer Research
state: Tokyo
city: Yonago-shi
country: Japan
facility: Tottori University Hospital
state: Tottori
city: Wakayama-shi
country: Japan
facility: Wakayama Medical University Hospital
state: Wakayama
city: Ube-shi
country: Japan
facility: National Hospital Organization Yamaguchi-Ube Medical Center
state: Yamaguchi
city: Busan
country: Korea, Republic of
facility: Pusan National University Hospital
city: Goyang-si Gyeonggi-do
country: Korea, Republic of
facility: National Cancer Center
city: Incheon
country: Korea, Republic of
facility: Gachon University Gil Hospital
city: Seoul
country: Korea, Republic of
facility: Korea University Anam Hospital
city: Seoul
country: Korea, Republic of
facility: Asan Medical Center
city: Seoul
country: Korea, Republic of
facility: Samsung Medical Center
city: Seoul
country: Korea, Republic of
facility: Korea University Guro Hospital
city: Yangsan-si, Gyeongsangnam-do
country: Korea, Republic of
facility: Pusan National University Yangsan Hospital
city: Riga
country: Latvia
facility: Pauls Stradins Clinical University Hospital
city: Riga
country: Latvia
facility: Riga East Clinical University Hospital
city: Kuantan
country: Malaysia
facility: Hospital Tengku Ampuan Afzan
state: Pahang
city: Kuala Lumpur
country: Malaysia
facility: Pantai Hospital Kuala Lumpur
state: Wilayah Persekutuan
city: Kuala Lumpur
country: Malaysia
facility: University Malaya Medical Centre
state: Wilayah Persekutuan
city: Mexico City
country: Mexico
facility: Health Pharma Professional Research SA de CV
state: Distrito Federal
city: Guadalajara
country: Mexico
facility: Hospital Civil de Guadalajara Fray Antonio Alcalde
state: Jalisco
city: Monterrey
country: Mexico
facility: Hospital Universitario Dr Jose Eleuterio Gonzalez
state: Nuevo León
city: Monterrey
country: Mexico
facility: Oncare
state: Nuevo León
city: Guadalajara
country: Mexico
facility: Actualidad Basada en la Investigación del Cáncer
city: Amersfoort
country: Netherlands
facility: Meander Medisch Centrum
city: Groningen
country: Netherlands
facility: Universitair Medisch Centrum Groningen
city: Harderwijk
country: Netherlands
facility: Sint Jansdal Ziekenhuis
city: Maastricht
country: Netherlands
facility: Maastricht Universitair Medisch Centrum
city: Tilburg
country: Netherlands
facility: Elisabeth-TweeSteden Ziekenhuis
city: Zwolle
country: Netherlands
facility: Isala Klinieken
city: Arequipa
country: Peru
facility: Centro de Investigacion Vallesur
city: Lima
country: Peru
facility: Oncosalud
city: Lima
country: Peru
facility: Unidad de Investigación Clínica Internacional Sede San Borja
city: Lima
country: Peru
facility: Hospital de Apoyo Departamental Maria Auxiliadora
city: Bialystok
country: Poland
facility: Uniwersytecki Szpital Kliniczny w Bialymstoku
city: Bystra
country: Poland
facility: Centrum Pulmonologii i Torakochirurgii w Bystrej
city: Gdynia
country: Poland
facility: Szpitale Pomorskie Spolka z ograniczona odpowiedzialnoscia
city: Krakow
country: Poland
facility: Szpital Specjalistyczny imienia Ludwika Rydygiera w Krakowie Sp zoo
city: Lodz
country: Poland
facility: Instytut Centrum Zdrowia Matki Polki
city: Lublin
country: Poland
facility: Uniwerystecki Szpital Kliniczny Nr 4 w Lublinie
city: Poznan
country: Poland
facility: Med Polonia Sp zoo
city: Przemysl
country: Poland
facility: Wojewodzki Szpital im Sw Ojca Pio w Przemyslu
city: Walbrzych
country: Poland
facility: Specjalistyczny Szpital im Dra Alfreda Sokolowskiego
city: Warszawa
country: Poland
facility: Narodowy Instytut Onkologii im Marii Sklodowskiej-Curie - Panstwowy Instytut Badawczy
city: Lisboa
country: Portugal
facility: Fundacao Champalimaud
city: Lisboa
country: Portugal
facility: Hospital da Luz, SA
city: Lisboa
country: Portugal
facility: Unidade Local de Saude de Santa Maria, EPE - Hospital Pulido Valente
city: Lisboa
country: Portugal
facility: Hospital Cuf Tejo
city: Matosinhos
country: Portugal
facility: Unidade Local de Saude de Matosinhos, EPE - Hospital Pedro Hispano
city: Porto
country: Portugal
facility: Hospital Cuf porto
city: Bucuresti
country: Romania
facility: Institutul Oncologic, Prof Dr Alexandru Trestioreanu
city: Bucuresti
country: Romania
facility: Spitalul Universitar de Urgenta Bucuresti
city: Cluj Napoca
country: Romania
facility: Institutul Oncologic Prof Dr Ion Chiricuta Cluj-Napoca
city: Cluj Napoca
country: Romania
facility: SC Medisprof SRL
city: Craiova
country: Romania
facility: Centrul de Oncologie Sf Nectarie SRL
city: Iasi
country: Romania
facility: Institutul Regional de Oncologie Iasi
city: Ploiesti
country: Romania
facility: Spitalul Municipal Ploiesti
city: Timisoara
country: Romania
facility: SC Oncomed SRL
city: Singapore
country: Singapore
facility: National University Hospital
city: Singapore
country: Singapore
facility: Tan Tock Seng Hospital
city: Malaga
country: Spain
facility: Hospital Regional Universitario de Malaga
state: Andalucía
city: Sevilla
country: Spain
facility: Hospital Universitario Virgen del Rocio
state: Andalucía
city: Zaragoza
country: Spain
facility: Hospital Clinico Universitario Lozano Blesa
state: Aragón
city: Las Palmas de Gran Canaria
country: Spain
facility: Hospital Universitario Insular de Gran Canaria
state: Canarias
city: Santander
country: Spain
facility: Hospital Universitario Marques de Valdecilla
state: Cantabria
city: Barcelona
country: Spain
facility: Hospital del Mar
state: Cataluña
city: Barcelona
country: Spain
facility: Hospital Universitari Vall d Hebron
state: Cataluña
city: Barcelona
country: Spain
facility: Hospital Clinic i Provincial de Barcelona
state: Cataluña
city: Barcelona
country: Spain
facility: Hospital de la Santa Creu i Sant Pau
state: Cataluña
city: Hospitalet de Llobregat
country: Spain
facility: Institut Catala d Oncologia Hospitalet Hospital Duran i Reynals
state: Cataluña
city: Valencia
country: Spain
facility: Hospital Clinico Universitario de Valencia
state: Comunidad Valenciana
city: Valencia
country: Spain
facility: Hospital Universitari i Politecnic La Fe
state: Comunidad Valenciana
city: A Coruña
country: Spain
facility: Complexo Hospitalario Universitario A Coruna Hospital Teresa Herrera
state: Galicia
city: Majadahonda
country: Spain
facility: Hospital Universitario Puerta de Hierro Majadahonda
state: Madrid
city: Madrid
country: Spain
facility: Fundacion Jimenez Diaz
city: Madrid
country: Spain
facility: Hospital Clinico San Carlos
city: Madrid
country: Spain
facility: Hospital Universitario La Paz
city: Goteborg
country: Sweden
facility: Sahlgrenska Universitetssjukhuset
city: Gävle
country: Sweden
facility: Gavle Sjukhus
city: Umea
country: Sweden
facility: Norrlands Universitetssjukhus
city: Aarau
country: Switzerland
facility: Kantonsspital Aarau
city: Baden
country: Switzerland
facility: Kantonsspital Baden
city: Basel
country: Switzerland
facility: Universitaetsspital Basel
city: Zuerich
country: Switzerland
facility: Universitaetsspital Zuerich
city: Taichung
country: Taiwan
facility: China Medical University Hospital
city: Taichung
country: Taiwan
facility: Veterans General Hospital - Taichung
city: Tainan
country: Taiwan
facility: National Cheng Kung University Hospital
city: Tainan
country: Taiwan
facility: Chi Mei Hospital, Liouying
city: Taipei
country: Taiwan
facility: National Taiwan University Hospital
city: Taipei
country: Taiwan
facility: Taipei Veterans General Hospital
city: Taoyuan
country: Taiwan
facility: Linkou Chang Gung Memorial Hospital
city: Bangkok
country: Thailand
facility: Vajira Hospital
city: Bangkok
country: Thailand
facility: King Chulalongkorn Memorial Hospital
city: Bangkok
country: Thailand
facility: Phramongkutklao Hospital
city: Chiang Mai
country: Thailand
facility: Maharaj Nakorn Chiang Mai Hospital
city: Khon Kaen
country: Thailand
facility: Srinagarind Hospital
city: Samut Sakhon
country: Thailand
facility: Banphaeo General Hospital
city: Songkla
country: Thailand
facility: Songklanagarind Hospital
city: Adana
country: Turkey
facility: Medical Park Seyhan Hastanesi
city: Ankara
country: Turkey
facility: Hacettepe Universitesi Tip Fakultesi Hastanesi
city: Ankara
country: Turkey
facility: Gazi Universitesi Saglik Arastirma ve Uygulama Merkezi Gazi Hastanesi
city: Ankara
country: Turkey
facility: Ankara Bilkent Sehir Hastanesi
city: Antalya
country: Turkey
facility: Akdeniz Universitesi Tip Fakultesi
city: Aydin
country: Turkey
facility: Aydin Adnan Menderes Universitesi Tip Fakultesi
city: Denizli
country: Turkey
facility: Pamukkale Universitesi Tip Fakultesi Hastanesi
city: Istanbul
country: Turkey
facility: Istanbul Universitesi Cerrahpasa Tip Fakultesi
city: Istanbul
country: Turkey
facility: Memorial Bahcelievler Hastanesi
city: Istanbul
country: Turkey
facility: Bagcilar Medipol Mega Universite Hastanesi
city: Istanbul
country: Turkey
facility: Goztepe Prof Dr Suleyman Yalcin Sehir Hastanesi
city: Istanbul
country: Turkey
facility: Marmara Universitesi Tip Fakultesi Hastanesi
city: Izmir
country: Turkey
facility: Dr Suat Seren Gogus Hastaliklari ve Cerrahisi Egitim ve Arastirma Hastanesi
city: Izmir
country: Turkey
facility: Izmir Ekonomi Universitesi Medical Point Hastanesi
city: Samsun
country: Turkey
facility: Ondokuz Mayis Universitesi Tip Fakultesi Hastanesi
city: Birmingham
country: United Kingdom
facility: Queen Elizabeth Hospital Birmingham
city: Inverness
country: United Kingdom
facility: Raigmore Hospital
city: London
country: United Kingdom
facility: Royal Marsden Hospital
city: Northwood
country: United Kingdom
facility: Mount Vernon Cancer Centre
city: Nottingham
country: United Kingdom
facility: Nottingham City Hospital
city: Sutton
country: United Kingdom
facility: Royal Marsden Hospital
city: Torquay
country: United Kingdom
facility: Torbay Hospital
city: Truro
country: United Kingdom
facility: Royal Cornwall Hospital
Study officials:
affiliation: Amgen
name: MD
role: STUDY_DIRECTOR
References: