louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT05536817: Sleep Disorder in Inflammatory Bowel Disease and Its Association With Disease Activity
Official title: Prevalence of Sleep Disorder in Inflammatory Bowel Disease and Its Association With Disease Activity
Study type: OBSERVATIONAL
Overall status: RECRUITING
Conditions: Sleep Disorder
Inflammatory Bowel Diseases
Lead sponsor: Mahidol University
Sponsor class: OTHER
First posted: 2022-09-13
Enrollment: 100
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: patients over 18 years of age diagnosed with inflammatory bowel disease, either UC or CD. In addition, patients with non-IBD-related conditions that potentially impacted sleep quality will be excluded

Brief summary: Recently, an association between active inflammatory bowel disease (IBD) and poor sleep quality has been proposed; however, the causal relationship has not yet been established. This study aimed to investigate prevalence of poor sleep quality in IBD and association with disease activity by subjective and objective measures.

Prospective observational study is conducted with expected sample size of 100 patients. Participants are classified into active and inactive disease status according to standard IBD severity assessment measures. Demographic data, disease activity, quality of life, sleep questionnaire (validated PSQI questionaire), and seven-day sleep data acquired from ambulatory wrist actigraphy were obtained. Association between sleep quality and disease activity will be analyzed.


Eligibility criteria: Inclusion Criteria:

* Age ≥ 18 years
* Diagnosed inflammatory bowel disease, followed up in Siriraj hospital, Mahidol University

Exclusion Criteria:

* Unstable medical conditions
* Known psychiatric disease
* Patients who could not withhold sedative drugs
* Pregnant patients
* Obese patients with body mass index (BMI) ≥ 35 kg/m2
* Refuse to sign a consent/ had cognitive impairment

Primary outcomes:
measure: Subjective sleep quality
timeFrame: 12 months
measure: Objective sleep quality
timeFrame: 12 months
Secondary outcomes:
Other outcomes:
Locations:
city: Bangkok
country: Thailand
facility: Gastroenterology division, Faculty of Medicine, Siriraj Hospital, Mahidol University
Study officials:
References:
Clinical trial NCT03008317: Microbial Adhesion to Metallic Versus Non Metallic Surfaces of Bounded Removable Partial Denture
Official title: Microbial Adhesion to Metallic Versus Non Metallic Surfaces of Bounded Removable Partial Denture
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Polyetheretherketone
Lead sponsor: Cairo University
Sponsor class: OTHER
First posted: 2017-01-02
Enrollment: 2
Sex: ALL
Minimum age (years): 40
Maximum age (years): 55
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: a split mouth randomized clinical trial that compares quantity and quality of bacterial adhesion under both PEEK versus cobalt chromium alloy denture base.

Detailed description: this study aimed to compare the adhesion of microorganisms to the non metallic denture base of PEEK and metallic denture base of cobalt chromium alloy in patients with class III modification 1

Eligibility criteria: Inclusion Criteria:

* patients are medically free

Exclusion Criteria:

* patients with badly broken abutments

Primary outcomes:
measure: microbial culture using number of clonies after insertion by 3 months
timeFrame: one year
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
References:
Clinical trial NCT03564717: Evaluation of Segmented Versus Full Arch Three Dimensionally Printed Transfer Tray for Orthodontic Indirect Bonding
Official title: Evaluation of Segmented Versus Full Arch Three Dimensionally Printed Transfer Tray for Orthodontic Indirect Bonding: Randomized Controlled Trial
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Inaccurate Transfer and Bond Failure of Conventional Indirect Bonding Tray
Accuracy of Bracket Transfer and Bond Failure Rate of Full Arch and Segmented Digitally Printed Trays
Lead sponsor: Cairo University
Sponsor class: OTHER
First posted: 2018-06-21
Enrollment: 132
Sex: ALL
Minimum age (years): 16
Maximum age (years): 38
Standard ages: CHILD
ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: OTHER

Brief summary: This study is conducted to overcome the problems of conventional indirect bonding technique, through investigating accuracy of two novel three dimensionally digitally printed indirect bonding transfer trays (full arch \& segmented) in terms of accuracy of transferring brackets, rate of immediate bond failure and chair side time.

Detailed description: Fourteen patients (7 in each group) with mild to moderate crowding, requiring orthodontic treatment with full set of permanent teeth including second molars, will be selected for this study. A total of 196 brackets will be used (98 Full Arch Tray and 98 Segment Arch Tray). The same bracket type and bonding material will used in both groups. The accuracy of bracket transfer will be measured by 3 Shape Ortho planner software (Bracket Placement Module), rate of bond failure by counting number of debonded brackets upon tray removal \& chair side time by using digital watch.

Eligibility criteria: Inclusion Criteria:

1. Patients seeking fixed orthodontic treatment with full set of permanent teeth including second molars.
2. No sex predilection.
3. Mild to moderate crowding cases (4-6 mm).

Exclusion Criteria:

1. Severely rotated teeth
2. Enamel hypoplasia or hypocalcification.
3. Systemic disease that contraindicates orthodontic treatment.
4. Presence of deep carious lesions or large restorations.
5. No or poor patient's compliance \& bad oral hygiene.
6. Psychological problems.

Primary outcomes:
measure: Accuracy of 3D printed full arch &segmented transfer tray.
timeFrame: immediate
Secondary outcomes:
measure: Chairside Time
timeFrame: immediate
measure: Immediate Bond Failure
timeFrame: immediate
Other outcomes:
Locations:
Study officials:
References:
Clinical trial NCT05837117: Sexual Dysfunction in Palliative Care Patients: An Assessment of Patient's Perspective
Official title: Sexual Dysfunction in Palliative Care Patients: An Assessment of Patient's Perspective
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Sexual Dysfunction
Lead sponsor: M.D. Anderson Cancer Center
Sponsor class: OTHER
First posted: 2023-05-01
Enrollment: 104
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: M D Anderson Cancer Center

Brief summary: To learn about the communications that Supportive Care patients receive about sexual well-being from their healthcare provider. Researchers also want to learn about your attitudes, beliefs, and feelings about sexual well-being.

Detailed description: Primary Objectives:

1. To determine the frequency of discussion about sexual dysfunction in palliative care patients.
2. To evaluate the impact of cancer diagnosis and treatment on patient's sexual life.

Secondary Objectives:

1. To evaluate patient self-reported severity of sexual dysfunction
2. To evaluate the proportion of patients suffering distress from body image concerns
3. To identify patient self-reported barriers that prevent discussion about sexual dysfunction
4. To evaluate patient self-reported impact of sexual dysfunction on their wellbeing

Eligibility criteria: Inclusion Criteria:

* All patients who are evaluated as follow-ups in the Supportive Care clinic, and able to voluntarily consent to participate in the study
* Patients must be able to understand, read, write, and speak English
* Diagnosis of cancer
* Patients who are 18 years of age or older

Exclusion criteria:

* New patients (consults)
* Patient who have declined to participate, or who are unable to consent

Primary outcomes:
measure: Quality of Life Questionnaires
timeFrame: through study completion an average of year
Secondary outcomes:
Other outcomes:
Locations:
city: Houston
country: United States
facility: M D Anderson Cancer Center
state: Texas
Study officials:
affiliation: M.D. Anderson Cancer Center
name: Patricia Bramati, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT04703517: Musculoskeletal Ultrasound for Diagnosis of Shoulder Dislocation Reduction
Official title: Musculoskeletal Ultrasonography to Diagnose Successful Reduction of Shoulder Dislocation
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Ultrasound
Shoulder Dislocation
Musculoskeletal Injury
Lead sponsor: Rutgers, The State University of New Jersey
Sponsor class: OTHER
First posted: 2021-01-11
Enrollment: 100
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: DIAGNOSTIC

Brief summary: This study will compare the current standard of care post reduction plain film x ray for confirmation of shoulder reduction to point of care ultrasound. Patients will receive both the current standard of care post reduction x ray and point of care ultrasound to act as their own comparators


Eligibility criteria: Inclusion Criteria:

* Adults greater than or equal to 18 years
* Acute shoulder dislocation

Exclusion Criteria:

* Associated fracture
* Associated neurovascular injury

Primary outcomes:
measure: Comparison of X ray to Ultrasound for Shoulder Reduction
timeFrame: through study completion up to 1 year
Secondary outcomes:
measure: Comparison of X ray to Ultrasound in the diagnosis of post shoulder reduction complications
timeFrame: through study completion up to 1 year
Other outcomes:
Locations:
Study officials:
References:
Clinical trial NCT01938417: Tobramycin Exposure From Active Calcium Sulfate Bone Graft Substitute
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Orthopedic Operations
Keywords: tobramycin
bone graft substitute
pharmacokinetics
renal failure
Lead sponsor: University of Lausanne Hospitals
Sponsor class: OTHER
First posted: 2013-09-10
Enrollment: 12
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: All adult patients treated with Osteoset® T in our orthopedic surgery department

Brief summary: This study aimed to assess the systemic absorption and disposition of tobramycin in patients treated with a tobramycin-laden bone graft substitute (Osteoset® T).


Eligibility criteria: Inclusion Criteria:

* Adult (\> or =18 years old) patients
* Treatment with Osteoset® T

Exclusion Criteria:

* Intravenous tobramycin

Primary outcomes:
measure: Measurement of systemic tobramycin concentration
timeFrame: within 10 days after surgery
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
References:
citation: Livio F, Wahl P, Csajka C, Gautier E, Buclin T. Tobramycin exposure from active calcium sulfate bone graft substitute. BMC Pharmacol Toxicol. 2014 Mar 4;15:12. doi: 10.1186/2050-6511-15-12.
Clinical trial NCT00482417: Efficacy and Safety Study of MK0359 in Patients With Arthritis (0359-017)
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE2
Conditions: Rheumatoid Arthritis
Lead sponsor: Merck Sharp & Dohme LLC
Sponsor class: INDUSTRY
First posted: 2007-06-05
Enrollment: 11
Sex: ALL
Minimum age (years): 18
Maximum age (years): 65
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: Efficacy and Safety Study of MK0359 in Patients with Arthritis


Eligibility criteria: Inclusion Criteria:

* You are 18-65 years of age and have Rheumatoid Arthritis
* You must be able to read and understand patient questionnaires

Exclusion Criteria:

* You have had certain types of surgery, certain types of cancer or history of Tuberculosis (TB) or HIV.

Primary outcomes:
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
affiliation: Merck Sharp & Dohme LLC
name: Medical Monitor
role: STUDY_DIRECTOR
References:
Clinical trial NCT02875717: Influence of Acetylsalicylic Acid and Low Molecular Weight Heparins on the Incidence of Renal Hematoma of Shockwave Lithotripsy
Official title: Influence of Acetylsalicylic Acid and Low Molecular Weight Heparins on the Incidence of Renal Hematoma of Shockwave Lithotripsy
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Urolithiasis
Renal Hematoma
Lead sponsor: Kantonsspital Winterthur KSW
Sponsor class: OTHER
First posted: 2016-08-23
Enrollment: 500
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: RETROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: All patients that received shockwave lithotripsy at Kantonsspital Winterthur between January 2009 and September 2015 and were 18 years or older at the time of treatment

Brief summary: Retrospective Analysis of patients that received shockwave lithotripsy as Treatment of ureteral or kidney Stones. Condition examinated is the effect of low molecular weight Heparins and acetylsalicylic acid on the Formation of renal hematoma after shockwave lithotripsy. Primary outcome is documented hematoma in a postoperative ultrasound control. Secondary outcomes are perioperative complication, Need for erythrocyte tranfusion, interventions for bleeding control, readmission or death within 30 days.


Eligibility criteria: Inclusion Criteria:

* consent
* Stones in kidney and proximal Ureter
* Treatment with shockwave lithotripsy for urolithiasis between January 2009 and September 2015 at Kantonsspital Winterthur

Exclusion Criteria:

* other Position of ureteral Stones
* missing data in Patient reports
* refused consent
* under Age limit

Primary outcomes:
measure: Renal Hematoma in ultrasound control
timeFrame: first day after intervention
Secondary outcomes:
measure: Intervention for bleeding control
timeFrame: 30 days after intervention
measure: Need for erythrocyte concentrate tranfusion
timeFrame: 30 days after intervention
measure: Death
timeFrame: 30 days after intervention
measure: Hospital readmission
timeFrame: 30 days after intervention
Other outcomes:
Locations:
city: Winterhur
country: Switzerland
facility: Kantonsspital Winterthur
state: Kanton Zürich
Study officials:
affiliation: Kantonsspital Winterthur KSW
name: Hubert John, M.D.
role: PRINCIPAL_INVESTIGATOR
References:
citation: Schregel C, John H, Randazzo M, Keller I. Influence of acetylsalicylic acid and low-molecular weight heparins on the formation of renal hematoma after shock wave lithotripsy. World J Urol. 2017 Dec;35(12):1939-1946. doi: 10.1007/s00345-017-2070-0. Epub 2017 Jul 12.
Clinical trial NCT03651817: Lung Protection Strategy in Open Heart Surgery: Which Tidal Volume is Better 8ml/kg or 6ml/kg
Official title: Lung Protection Strategy in Open Heart Surgery: Which Tidal Volume is Better 8ml/kg or 6ml/kg
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Lung Injury, Acute
Ventilator-Induced Lung Injury
Ventilator Adverse Event
Lead sponsor: Kocaeli University
Sponsor class: OTHER
First posted: 2018-08-29
Enrollment: 32
Sex: ALL
Minimum age (years): 18
Maximum age (years): 75
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: PREVENTION

Brief summary: Respiratory complications range from 8% to 79% of the frequency after open heart surgery where the patient is on-pump operated by cardiopulmonary machine. There were many changes in physiology due to anesthesia and cardiac surgery which cause volume and barotrauma complications with mechanical ventilation. These complications increase cost by prolonging morbidity and morbidity as well as hospital stay. Intraoperative and postoperative mechanical ventilation strategies can prevent these complications. CPB stimulates the systemic inflammatory response to the secretion of neutrophil, endotoxin and proinflammatory cytokines in the complex, increasing the permeability of the capillaries. Although coronary artery bypass graft surgery (CABG) is associated with a 0.4% to 2.0% acute respiratory distress syndrome (ARDS), mortality is quite high. Lung-protective ventilation strategies commonly used for prevention of ARDS. Ferrando et al. have proposed pulmonary ventilation with a tidal volume (TV) of less than 10 mL / kg as a pulmonary intraoperative protective ventilation strategy. Investigators aimed to compare oxygenation and ventilation parameters with respiratory mechanics in patients who underwent open heart surgery and were ventilated with 6 ml / kg tidal volume and 8 ml / kg TV, which were recommended as lung protective ventilation strategies during anesthesia.


Eligibility criteria: Inclusion Criteria:

* Undergoing Cardiopulmonary bypass

Exclusion Criteria:

* Severe COPD
* Chronic Anemia
* Active Smoker
* Chronic kidney Disease

Primary outcomes:
measure: Change of arterial carbondiokside pressure levels
timeFrame: from the beginning of operation to 6th hour of post-extubation
Secondary outcomes:
measure: Changes in respiratory parameters
timeFrame: from the beginning of the operation to the end of the surgery
measure: Changes in Invasive blood pressures
timeFrame: from the beginning of the operation to the end of the surgery
measure: Changes in heart rate
timeFrame: from the beginning of the operation to the end of the surgery
measure: Changes in central venous pressure
timeFrame: from the beginning of the operation to the end of the surgery
Other outcomes:
Locations:
city: Kocaeli
country: Turkey
facility: Kocaeli University Hospital
Study officials:
References:
Clinical trial NCT03426917: Anesthetic Complication Among Acute Ischemic Stroke Patients During Endovascularization Therapy
Official title: Anesthetic Complication Among Acute Ischemic Stroke Patients During Endovascularization Therapy, Retrospective Descriptive Study
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Anesthetic Complication
Lead sponsor: Mahidol University
Sponsor class: OTHER
First posted: 2018-02-08
Enrollment: 93
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: OTHER
Time perspective: RETROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: - The patients' chart of acute ischemic stroke patients who received endovascular therapy from January 2015 to December 2016

Brief summary: Retrospective descriptive study

Detailed description: Retrospective chart review from January 2014 to December 2015

Eligibility criteria: Inclusion Criteria:

- Acute ischemic stroke patients who received endovascular therapy from January 2015 to December 2016

Exclusion Criteria:

- Age less than 18 years old

Primary outcomes:
measure: Anesthetic Complication
timeFrame: Up to 24 hours
Secondary outcomes:
Other outcomes:
Locations:
city: Bangkok
country: Thailand
facility: Anesthesiology Department
Study officials:
affiliation: Mahidol University
name: Phuriphong Songarj, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT00162617: The Effect of Liberal vs. Restrictive Transfusion Strategies on Rehabilitation After Hip Fracture Surgery
Official title: The Effect of Liberal vs. Restrictive Transfusion Strategies on Rehabilitation After Hip Fracture Surgery
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: PHASE4
Conditions: Hip Fracture
Keywords: Hip fracture
Rehabilitation
Transfusion
Outcome
Lead sponsor: Hvidovre University Hospital
Sponsor class: OTHER
Collaborators: name: IMK Fonden
First posted: 2005-09-13
Enrollment: 120
Sex: ALL
Minimum age (years): 65
Standard ages: OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: To examine the effect of two different transfusion regimens on rehabilitation after hip fracture surgery.

Detailed description: The effect of liberal vs restrictive transfusion regimens after hip fracture surgery is unresolved. Liberal transfusion regimens (transfusion trigger hgb. 6.25 mmol/l) leads to an increased use of blood products but may impact positively on rehabilitation outcome, a restrictive transfusion trigger (hbg. 5.0 mmol/l) saves blood products but may also impair postoperative rehabilitation and outcome. the study randomizes 120 elderly patients with hip fractures to either a restrictive or a liberal perioperative transfusion therapy and measures postoperative rehabilitation outcomes within a well defined multimodal rehabilitation regimen.

Eligibility criteria: Inclusion Criteria:

* Primary hip fracture
* capable of informed consent
* independently dwelling
* able to ambulate independent of human assistance
* no active heart condition defined as no AMI within 3 months, no unstable angina or present incompensation/pulmonary oedema
* no regular transfusion demand or terminal disease.

Exclusion Criteria:

* Multiple fractures
* postop. immobilization due to to surgical reasons
* patient refusal to participate in relevant rehabilitation
* reoperation within 4. postoperative day.

Primary outcomes:
measure: Postoperative Functional mobility
measure: Restricting factors for functional mobility
Secondary outcomes:
measure: Length of stay
measure: Complications
measure: Dizziness
measure: Exhaustion
measure: Haematoma (leg swelling)
Other outcomes:
Locations:
city: Hvidovre
country: Denmark
facility: Hvidovre University Hospital
Study officials:
affiliation: Hvidovre University Hospital
name: Nicolai B Foss, MD
role: STUDY_DIRECTOR
References:
citation: Carson JL, Stanworth SJ, Dennis JA, Trivella M, Roubinian N, Fergusson DA, Triulzi D, Doree C, Hebert PC. Transfusion thresholds for guiding red blood cell transfusion. Cochrane Database Syst Rev. 2021 Dec 21;12(12):CD002042. doi: 10.1002/14651858.CD002042.pub5.
citation: Foss NB, Kristensen MT, Jensen PS, Palm H, Krasheninnikoff M, Kehlet H. The effects of liberal versus restrictive transfusion thresholds on ambulation after hip fracture surgery. Transfusion. 2009 Feb;49(2):227-34. doi: 10.1111/j.1537-2995.2008.01967.x.
Clinical trial NCT00226317: Aripiprazole in the Treatment of Bipolar Depression
Official title: Phase 4 Study: An Open Prospective Study of the Safety and Effectiveness of Aripiprazole in the Treatment of Bipolar Depression
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Bipolar Disorder
Lead sponsor: Cambridge Health Alliance
Sponsor class: OTHER
Collaborators: name: Bristol-Myers Squibb
First posted: 2005-09-27
Enrollment: 20
Sex: ALL
Minimum age (years): 18
Maximum age (years): 64
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: TREATMENT

Brief summary: A systematic open-label prospective pilot study to assess aripirazole for acute bipolar depression, with a secondary assessment of longer-term mood stabilization.

Detailed description: Study is 6 weeks long with 7 clinical visits.

Eligibility criteria: Inclusion Criteria:

* DSM-IV diagnosis of bipolar disorder, any subtype; MADRS \>16; MRS \< 10; not currently taking other mood stabilizers; women of reproductive potential must use an acceptable method of birth control

Exclusion Criteria:

* Current substance abuse within past month; serious unstable medical condition; active suicidal ideation; pregnant, trying to become pregnant, or nursing; intent to continue or initiate herbal preparations

Primary outcomes:
measure: Depression state
timeFrame: 6 week study
Secondary outcomes:
Other outcomes:
Locations:
city: Cambridge
country: United States
facility: Cambridge Health Alliance
state: Massachusetts
Study officials:
affiliation: Cambridge Health Alliance
name: Robert T Dunn, MD, PhD
role: PRINCIPAL_INVESTIGATOR
References: