Clinical trial NCT03160989: Acute and Chronic Responses to Blood Pressure After Exercise
Official title: Acute and Chronic Responses to Blood Pressure After Exercise
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Arterial Hypertension
Keywords: Blood pressure variability
Combined physical exercise
Hypertension
Lead sponsor: Federal University of Uberlandia
Sponsor class: OTHER
First posted: 2017-05-19
Enrollment: 14
Sex: FEMALE
Minimum age (years): 50
Maximum age (years): 70
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: HEALTH_SERVICES_RESEARCH

Brief summary: The study will evaluate the variability of blood pressure in postmenopausal and hypertensive women after only one session and after training of ten weeks of combined physical exercises (aerobic and resisted).

Detailed description: Before starting the training program, all the volunteers will sign the Free and Informed Consent Form (TCLE) and must present a medical certificate releasing the participation. In addition, the volunteers will respond to an anamnesis questionnaire and will undergo an anthropometric evaluation before the experimental sessions. The physical exercise program will be held three times a week for 10 weeks, containing aerobic exercise (exercise treadmill) and resistance exercises (bodybuilding). Initially, a familiarization of the ergometers used will be performed, followed by a session to evaluate the intensity of resistance exercise through a maximal repetition test (1RM), and a session to evaluate aerobic fitness through an incremental treadmill test.

Before starting the training, volunteers will perform a single exercise session, following the same exercise protocol. All the volunteers will be submitted to the evaluation of the blood pressure during 24 hours through the measurement of ambulatory blood pressure (ABPM) in three moments:

* PR: pre-training rest - the volunteers will arrive at the laboratory, will be in rest for 15 minutes and after that they will place the ABPM, without having done any exercise.
* PE: post exercise - upon arriving at the laboratory, the volunteers will be submitted to a single combined exercise session, will have a maximum interval of 20 minutes for the bath and will place the MAP device.
* CR: rest after chronic training - after the end of the 10 weeks of training, the volunteers will be submitted to ABPM, again at rest, with a maximum interval of 72 hours, between the end of the training and the placement of the device.

Eligibility criteria: Inclusion Criteria:

* Women aged between 50 and 70 years;
* Be in the postmenopausal phase;
* Be able to practice physical exercise on treadmill and resistance exercises (bodybuilding).
* Present stage 1 hypertension, according to the guidelines of the Brazilian Society of Hypertension
* Make use of anti-hypertensive medication, except beta-blockers
* Participants should be evaluated with a cardiologist beforehand and present a certificate attesting that they are able to perform physical activities.
* Do not present physical problems or cardiovascular complications that prevent the performance of physical exercises.

Exclusion Criteria:

* Make use of beta-blockers
* Present history of stroke or acute myocardial infarction;
* Smoking;
* Present diagnosis of Diabetes Mellitus.
* Present renal pathologies
* Use hormone replacement therapies

Primary outcomes:
measure: Change in ambulatory blood pressure variability in ten weeks
timeFrame: After ten weeks and before ten weeks of exercise training
Secondary outcomes:
measure: Comparison resting blood pressure
timeFrame: After ten weeks and before ten weeks of exercise training
measure: Anthropometric assessments
timeFrame: After ten weeks and before ten weeks of exercise training
Other outcomes:
Locations:
Study officials:
affiliation: Federal University of Uberlandia
name: LARISSA A SANTOS MATIAS, Graduate
role: PRINCIPAL_INVESTIGATOR
References:
citation: Gomes Anunciacao P, Doederlein Polito M. A review on post-exercise hypotension in hypertensive individuals. Arq Bras Cardiol. 2011 May;96(5):e100-109. Epub 2011 Mar 4. English, Portuguese, Spanish.
citation: Coylewright M, Reckelhoff JF, Ouyang P. Menopause and hypertension: an age-old debate. Hypertension. 2008 Apr;51(4):952-9. doi: 10.1161/HYPERTENSIONAHA.107.105742. Epub 2008 Feb 7. No abstract available.
citation: Puga GM, Kokubun E, Simoes HG, Nakamura FY, Campbell CS. Aerobic fitness evaluation during walking tests identifies the maximal lactate steady state. ScientificWorldJournal. 2012;2012:769431. doi: 10.1100/2012/769431. Epub 2012 May 1.