Clinical trial NCT06063889: Maximal Rate of Force Development of Ankle Muscles and Functional Ability in Patients With Knee Osteoarthritis
Official title: Assessment of Maximal Rate of Force Development of Ankle Muscles and Its Association Functional Ability in Patients With Knee Osteoarthritis
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Knee Osteoarthritis
Knee Arthritis
Lead sponsor: Ahram Canadian University
Sponsor class: OTHER
First posted: 2023-10-03
Enrollment: 126
Sex: ALL
Minimum age (years): 30
Maximum age (years): 45
Standard ages: ADULT
Accepts healthy volunteers: yes
Observational model: CASE_CONTROL
Time perspective: CROSS_SECTIONAL
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Patients suffering from knee osteoarthritis.

Brief summary: This study is a detailed assessment of the maximal rate of force development of ankle muscles and its association with functional ability in patients with knee osteoarthritis (OA).

Detailed description: This research is designed to study the link between force development in ankle muscles and functional abilities in knee OA patients. It aims to understand the influence of ankle muscle strength, specifically plantar flexors, on the stability, pain, and functionality of patients with knee OA. The study will analyze the rate of force development, its importance in explosive strength improvement, and impact on preventing knee injuries. Furthermore, it will investigate the compensatory mechanism of the plantar flexors developed by patients in advanced stages to balance other muscle failures.

Eligibility criteria: Inclusion Criteria:

* Group 1 (Knee OA group)

  1. Patients diagnosed with knee osteoarthritis according to Performance of the 2018 classification criteria for early stage knee OA was tested using data from the Osteoarthritis Initiative (OAI (Leung et al.,2020).
  2. Grade 2-3 KOA cases according to Kelgren-Lawrance classification
  3. Having knee pain for at least 6 months.
  4. The visual analog scale (VAS) score being at least 3 or more.
* Group 2 (Healthy control group) 1. Individuals with no signs or symptoms of Knee OA or other neurological or musculoskeletal conditions.

Exclusion Criteria:

1. Patellar subluxation
2. Surgery in any joint of the lower limb
3. Meniscal injury
4. Ligament instability
5. Patients who received intra-articular injection in the knee in the last 6 months
6. Patients with problems in the hip and ankle
7. Patients who participated in in another physical therapy program in the last 3 months were not included in the study.

Primary outcomes:
measure: Knee Osteoarthritis Outcome Score (KOOS)
timeFrame: Baseline
measure: Forward Step Down Test (FSDT)
timeFrame: Baseline
measure: Single Leg Hop Test (SLHT)
timeFrame: Baseline
measure: Isokinetic Testing Procedures
timeFrame: Baseline
measure: Rate of Force Development (RFD)
timeFrame: Baseline
Secondary outcomes:
Other outcomes:
Locations:
city: Al Ḩayy Ath Thāmin
country: Egypt
facility: Outpatient clinic of faculty of physical therapy, Ahram Canadian University
state: Giza
Study officials:
affiliation: Cairo University
name: Abeer Abdelrahman, Ph.D
role: STUDY_CHAIR
References: