Clinical trial NCT05315037: Resistance Training in Type 1 Diabetes Mellitus
Official title: Resistance Training Methods Impact On Glycemic Excursion and Metabolic Pathways in Type 1 Diabetes Mellitus
Study type: INTERVENTIONAL
Overall status: RECRUITING
Phase: NA
Conditions: Type 1 Diabetes
Keywords: Resistance Training in type 1 diabetes
Lead sponsor: University of Louisville
Sponsor class: OTHER
Collaborators: name: Norton Healthcare
First posted: 2022-04-07
Enrollment: 15
Sex: ALL
Minimum age (years): 13
Maximum age (years): 17
Standard ages: CHILD
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Intervention model description: Blood glucose and lactate measurements will be collected prior to any physical activity, post workout, and then 10- and 20-minutes post workout. Using a standard lancet device, capillary blood glucose values will be obtained using a Contour Next Glucometer.
Primary purpose: OTHER

Brief summary: The purpose of this study is to learn how different resistance training programs affects blood sugar in young athletes with T1DM.

Detailed description: Strength and condition training to improve sport performance has been greatly emphasized over the past 20 years. Formal strength and conditioning (S\&C) programming is performed by S\&C coaches who are educated in the field of exercise program with the intentions to bring about particular athletic adaptations through exercise. S\&C programs, previously limited to programs at the college and professional level, are now commonly seen in secondary school athletic programs. With such broad adoption, many athletes that manage chronic diseases, such as type 1 diabetes mellitus, are exposed to elements of these programs.

Diabetes mellitus impacts more than 10% of the United States population. Of these, 5.2% have identified type 1 diabetes mellitus (T1DM) which includes approximately 210,000 individuals under the age of 20. In addition to insulin and dietary management, exercise and physical activity is recommended as an important therapeutic tool for most patients with T1DM. Physical activity has been shown to significantly improve glycemic control in individuals with diabetes. Additional benefits of exercise include improved cardiovascular fitness, muscle strength, insulin sensitivity and blood glucose control. S\&C programs offer benefits to those living with T1DM as different exercises can be tailored to preserve health. However, there are no exercise prescription or guidelines specifically for adolescent athletes diagnosed with type 1 diabetes participating in strength and conditioning programs. Furthermore, there is no available data that states the predictability of glucose response and insulin needs to any of the specific strength and conditioning goals.

Objective: To assess the impact of different strength and conditioning programming on glycemic control in athletes with T1DM.

Primary Aim: Assess glucose response to different resistance training methods. Secondary Aims: To assess for correlation between lactate and glucose using different resistance training methods.

Eligibility criteria: Inclusion Criteria:

* ≥ 13 years of age
* ≥2 years from date of T1DM diagnosis
* Prior exposure to strength and conditioning
* HbA1C ≤ 10%
* Actively utilizing continuous glucose monitoring for diabetes management

Exclusion Criteria:

* Physical limitation that may impede ability to complete study procedures
* Non-English-speaking individual

Primary outcomes:
measure: Assess glucose response to different resistance training methods
timeFrame: 3 months
Secondary outcomes:
measure: To assess for correlation between lactate and glucose using different resistance training methods
timeFrame: 3 months
Other outcomes:
Locations:
city: Louisville
country: United States
facility: Norton Healthcare
state: Kentucky
city: Louisville
country: United States
facility: University of Louisville
state: Kentucky
Study officials:
References: