louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT05794828: Erector Spinae Regional Anesthesia for Pain Control
Official title: Erector Spinae Regional Anesthesia for Pain Control in the Emergency Department
Study type: INTERVENTIONAL
Overall status: RECRUITING
Phase: EARLY_PHASE1
Conditions: Pain Management
Keywords: Erector spinae plane block
ESPB
Pain reduction
Lead sponsor: The University of Texas Health Science Center at San Antonio
Sponsor class: OTHER
First posted: 2023-04-03
Enrollment: 40
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Intervention model description: Single group open label assignment
Primary purpose: TREATMENT

Brief summary: Interventional study to use erector spinae plane block (ESPB) on diagnoses of posterior or lateral rib fractures, vertebral fractures, pancreatitis, pancreatic cancer, renal colic, and back pain for multimodal pain therapy to determine its assistance with pain relief as well as the patient's use of opiates after block completion

Detailed description: Patients with the listed diagnoses will be offered and then consented for an ESPB under ultrasound guidance. They will rate their pain before and 30 minutes after the procedure using the ordinal categorical data on a numeric pain scale. Total patient opiate use will be gathered up to 8 hours after block completion.

Eligibility criteria: Inclusion Criteria:

* Posterior/lateral rib or vertebral fractures
* Pancreatitis or pancreatic cancer
* Renal colic
* Back pain

Exclusion Criteria:

* Unstable vitals
* Infection or open wound over insertion site
* Prior allergic reaction to local anesthetic
* Pregnant females
* Patients \<18 years old
* Altered mentation

Primary outcomes:
measure: Pain Scale Rating
timeFrame: Baseline to study procedure end (approximately 30 minutes)
Secondary outcomes:
Other outcomes:
Locations:
city: Ridley Park
country: United States
facility: Crozer Chester Medical Center
state: Pennsylvania
city: Upland
country: United States
facility: Crozer Chester Medical Center
state: Pennsylvania
city: San Antonio
country: United States
facility: University Hospital
state: Texas
city: Temple
country: United States
facility: Baylor Scott & White
state: Texas
Study officials:
affiliation: University of Texas Health Science Center San Antonio
name: Morgan Ritz, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT06986928: A Network Analysis on the Role of Specific ER Abilities as ERFs for Distress and Mental Health, in Relation to CAs Exposure in the AYAs
Official title: A Network Analysis on the Role of Specific Emotion Regulation Abilities as Emotional Resilience Factors for Distress and Mental Health, in Relation to Childhood Abuse Exposure in Adolescents and Young Adults
Study type: OBSERVATIONAL
Overall status: NOT_YET_RECRUITING
Conditions: Emotional Resilience
Lead sponsor: Babes-Bolyai University
Sponsor class: OTHER
Collaborators: name: The Executive Agency for Higher Education, Research, Development and Innovation Funding
First posted: 2025-05-23
Enrollment: 349
Sex: ALL
Minimum age (years): 10
Maximum age (years): 24
Standard ages: CHILD
ADULT
Accepts healthy volunteers: yes
Observational model: ECOLOGIC_OR_COMMUNITY
Time perspective: CROSS_SECTIONAL
Sampling method: NON_PROBABILITY_SAMPLE
Study population: School- and university-aged students recruited from educational institutions in Cluj-Napoca.

Brief summary: This activity will aim to compare the network of emotional resilience factors and stress in adolescents and young adults depending on the childhood abuse exposure (considered moderator), using a network analysis approach.

Detailed description: Participants included in this study (age range = 10-24, G\*power estimated N = 349) will complete a set of questionnaires on constructs that are focusing on or closely related to resilience and mental health, in order to investigate the dynamics of emotional resilience factors in relation to mental health outcomes such as anxiety and depression, taking into account the moderating effects of childhood abuse exposure.

Eligibility criteria: Inclusion Criteria:

* adolescents and young adults between 10 and 24 years old provided with written parental consent where applicable

Exclusion Criteria:

* intellectual disability or physical limitations precluded the use of the computer program

Primary outcomes:
measure: Childhood Trauma Exposure
timeFrame: Baseline
measure: Emotion regulation abilities
timeFrame: Baseline
measure: Emotional and behavioral difficulties
timeFrame: Baseline
measure: Stress
timeFrame: Baseline
Secondary outcomes:
Other outcomes:
Locations:
city: Cluj-Napoca
country: Romania
facility: Babes-Bolyai University
state: Cluj
Study officials:
affiliation: Babes-Bolyai University
name: Oana A. David, Ph.D
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT05749328: Effect of Preoperative Oral Carbohydrate on Hypotension After Anesthesia Induction in Elderly Patients With Joint Replacement
Official title: Effect of Preoperative Oral Carbohydrate Shortening the Fasting Period on Hypotension After Anesthesia Induction in Elderly Patients With Joint Replacement
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Carbohydrates
Aged
Post-induction Hypotension
Lead sponsor: Second Affiliated Hospital, School of Medicine, Zhejiang University
Sponsor class: OTHER
First posted: 2023-03-01
Enrollment: 210
Sex: ALL
Minimum age (years): 65
Maximum age (years): 80
Standard ages: OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: PREVENTION

Brief summary: The goal of this Randomized controlled trial is to investigate the effect of shortening the duration of preoperative oral carbohydrate drinks on blood pressure after anesthesia induction in elderly patients undergoing joint replacement surgery. The main question it aims to answer is Whether preoperative oral carbohydrate drinks can reduce the incidence of hypotension after anesthesia-induced hypotension in elderly patients undergoing joint replacement surgery.According to the numerical table method, the patients in the experimental group will drink carbohydrate drinks the night before the operation and 3 hours before the operation, and the control group patients will routinely fast


Eligibility criteria: Inclusion Criteria:

1. Patients undergoing elective unilateral joint replacement (total hip or knee)
2. ASAⅠ-Ⅲ

Exclusion Criteria:

1. Diagnosed patients at high risk of reflux aspiration (diabetes mellitus, obesity (BMI\>30), gastrointestinal obstruction, elevated intracranial pressure, and esophageal disease)
2. Eating disorders
3. History of gastrointestinal or epigastric surgery
4. Recent use of drugs that affect gastrointestinal motility
5. Heart disease (severe arrhythmias, severe heart valve disease, heart failure, unstable angina on the day of surgery)
6. Severe poorly controlled hypertension (MAP≥135 mmHg) or hypotension (MAP≤55 mmHg) before induction
7. Difficult airway
8. Severe hepatic and renal insufficiency

Primary outcomes:
measure: Incidence of hypotension
timeFrame: 20 minutes after induction of anesthesia
Secondary outcomes:
measure: Duration of fasting and drinking
timeFrame: 1 day before the operation
measure: Antral cross-sectional area
timeFrame: 30 minutes before anesthesia induction
measure: Incidence of hypotension
timeFrame: during the whole operation
measure: The dosage of vasoactive drugs
timeFrame: 20 minutes after induction of anesthesia
measure: Thirst and hunger VAS score
timeFrame: 3 hours before and 1 day after the operation
measure: Fasting blood glucose and insulin resistance index
timeFrame: 3 hours before the operation
measure: Incidence of nausea and vomiting
timeFrame: 1 day after the operation
Other outcomes:
Locations:
Study officials:
affiliation: The second affiliated hospital of Zhejiang University hangzhou
name: min yan, prof.
role: STUDY_CHAIR
References:
Clinical trial NCT03430128: Perioperative Immunonutrition for Patients Undergoing CRS and HIPEC
Official title: Perioperative Immunonutrition for Patients Undergoing Cytoreductive Surgery (CRS) and Hyperthermic Intraperitoneal Chemotherapy
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Peritoneal Metastases
Lead sponsor: National Cancer Centre, Singapore
Sponsor class: OTHER
First posted: 2018-02-12
Enrollment: 70
Sex: ALL
Minimum age (years): 21
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: SUPPORTIVE_CARE

Brief summary: Patients with peritoneal disease commonly present with symptoms of abdominal distension and subacute intestinal obstruction. This results in poor oral intake leading to these patients often presenting in a malnourished state.

CRS and HIPEC can potential provide improve survival for these patients, however can be a hazardous procedure, involving multi-organ resections. The risk is especially high in poorly nourished patients.

The study investigators hypothesize that perioperative immunonutrition can reduce wound infections and length of hospital stay, and improve perioperative outcomes. To the investigators' knowledge, it has not been evaluated in patients undergoing CRS and HIPEC.


Eligibility criteria: Inclusion Criteria:

1. All patients planned for CRS and HIPEC, with sufficient time (5 to 7 days) prior to surgery for start of nutritional supplements are eligible
2. All patients must be able to provide informed consent
3. There are no restrictions to use of contraception

Exclusion Criteria:

1. Patients who are not able to provide informed consent will be excluded.
2. Patients with a diagnosis of diabetes mellitus will be excluded.
3. Patients not fit for surgery or those who undergo surgery under emergency situations will be excluded.
4. Patients who have intestinal obstruction and not able to consume the nutritional supplements orally will be excluded.

Primary outcomes:
measure: Baseline wound infection rates
timeFrame: From date of surgery to date that wound is healed, up to 30 days from surgery
Secondary outcomes:
measure: Peri-operative complications
timeFrame: Within 30 days from surgery
measure: Length of stay
timeFrame: 100 days
Other outcomes:
Locations:
city: Singapore
country: Singapore
facility: National Cancer Centre Singapore
Study officials:
affiliation: National Cancer Centre, Singapore
name: Melissa Teo, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT06929728: Automatic and Conventional Methods of Hypertensive Patients Monitoring
Official title: Copmaring Automatic Blood Preesure Measurments To Conventional Office Readings For Monitoring Hypertensive Patients And Predicting Hypertention Mediated Organ Damage
Study type: OBSERVATIONAL
Overall status: NOT_YET_RECRUITING
Conditions: Primary Hypertension
Keywords: HTN , HMOD ,BP , LVH ,LAE
Lead sponsor: Assiut University
Sponsor class: OTHER
First posted: 2025-04-16
Enrollment: 620
Sex: ALL
Minimum age (years): 18
Maximum age (years): 70
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: OTHER
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: A calculated minimum sample of 620 male and female hypertensive patients aged more than 18 years old recruited from outpatient clinic of assiut cardiology departement will be randomly assigned 1:1 design.

Brief summary: comparing automatic blood pressure measurments methods with conventional office methods in follow up and monitoring of hypertensive patients and predicting hypertension mediated organ damage .

Detailed description: Close monitoring of hypertensive patients using home and ambulatory blood pressure measurments and its role in predicting hypertention mediated organ damage. Echocardiography assessment for hypertensive patients and its important role in early detection and prevention of changes such as left ventricular hypertrophy,left atrial enlargement ,systolic and diastolic dysfunction and left ventricular mass . Microalbumiuria and early detection of renal impairment. Important role of close monitoring in management and control of hypertention and reduction of hypertensive emergencies and improvement of outcomes ,addherence to treatment , reduce of office consultation , improvement of psycosochial life ,reduce hospitalization cost and mortality rates . Digital apps has a good role in improve healthy life style and rapid detection of blood presssure changes during daily activities.

Eligibility criteria: Inclusion Criteria:

* Patients who were screening for suspected hypertention or white coat hypertention .
* medically underserved population .
* primary arterial hypertention .
* high risk hypertensive patients \[resistant hypertension ,patients with poor medication adherance \]

Exclusion Criteria:

* patients with secondary causes of hypertention
* patients with other cardiac diseases \[heart faliure ,valvular heart diseases \]
* chronic illness affect blood pressure as chronic kideny disease .

Primary outcomes:
measure: predictive accuracy of automatic blood pressure measurments versus conventional office based measurments in identifying patient at risk of hypertension mediated organ damage [HMOD] .
timeFrame: over 6 months follow up period
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
References:
Clinical trial NCT00822328: Fermented Milk Drink on Human Intestinal Microflora
Official title: Effects of a Fermented Milk Drink Containing Lactobacillus Casei Strain Shirota on the Human Intestinal Microflora
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE2
Conditions: Signs and Symptoms, Digestive
Keywords: Probiotics
Lactobacillus
Intestine
Flora
Lead sponsor: Cheng Hsin Rehabilitation Medical Center
Sponsor class: OTHER
First posted: 2009-01-14
Enrollment: 24
Sex: ALL
Minimum age (years): 20
Maximum age (years): 65
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: BASIC_SCIENCE

Brief summary: Fermented milk is a popular drink. Recent studies revealed that some fermented milk containing some strains of lactic acid bacteria have health-promoting effects through improvement of the intestinal microflora and modulation of the immune system. Lactobacillus casei strain Shirota (LcS) is a probiotic bacterium used in the production of fermented milk products and lactic acid bacteria preparations. LcS has been shown to modify allergen-induced immune responses in allergic rhinitis, altering fermentation patterns in the small bowel, prevention of recurrent urinary tract infections in women. Yakult®300 is a fermented milk containing at least 3x10\^10 live LcS cells per 100 ml bottle. This study aimed to evaluate the effects of a fermented milk drink containing Lactobacillus casei strain Shirota on the human intestinal microflora.


Eligibility criteria: Inclusion Criteria:

* Healthy adult volunteers and willing to give voluntary written informed consent

Exclusion Criteria:

* Major systemic disease
* Pregnancy, parturient and feeding woman, or expect to be pregnant
* Abnormal liver function
* Abnormal renal function
* Abnormal gastrointestinal function
* Take medication for gastrointestinal function
* Stroke, myocardial infarction,
* Poor compliance for study protocol

Primary outcomes:
measure: Modification of the Composition of the Intestinal Microflora: Bifidobacterium
timeFrame: week 0, 1, 2, 3, 4, 5, 6.
measure: Modification of the Composition of the Intestinal Microflora: Clostridium Perfringens
timeFrame: week 0, 1, 2, 3, 4, 5, 6.
Secondary outcomes:
measure: Modification of the Composition of the Intestinal Microflora: Escherichia Coli, Lactobacillus Spp., Lactobacillus Casei Shirota
timeFrame: at week 0, 1, 2, 3, 4, 5, 6
Other outcomes:
Locations:
city: Taipei
country: Taiwan
facility: Division of Radiotherapy, Cheng Hsin Rehabilitation Medical Center
Study officials:
affiliation: Division of Radiotherapy, Cheng Hsin Rehabilitation Medical Center
name: Yi-Hsien Lin, M.D.
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT01260428: Effects of Expiratory Pressure on Arterial Oxygenation During Hypoxia
Official title: Arterial Oxygenation During Hypoxia : Effects of an Added Expiratory Resistance
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Hypoxia
Keywords: hypoxia
O2 diffusion and convection
cardiac output
PEEP
Effects of hypoxia
Lead sponsor: AGIR à Dom
Sponsor class: OTHER
First posted: 2010-12-15
Enrollment: 20
Sex: FEMALE
Minimum age (years): 18
Maximum age (years): 65
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: CASE_ONLY
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: community sample with mounteneering experience

Brief summary: Altitude tolerance correlates with the level of oxygenation achieved. The aim of the present study is to investigate whether increased expiratory pressure within the thorax is able to improve oxygenation during hypoxic hypoxia.

Detailed description: Two types of procedures will be tested in a random order, interspaced by resting periods : threshold PEEP set at 5,10 and 15 cm of water and pursed leap breathing.

Subjects will be tested at rest, and during light exercise (30% of sea level predicted VO2max).

FiO2 will be set at 12.5% (4000 m). fc, VE, PETCO2, TA, ECG, cardiac output, and tissular oxygenation will be monitored.

Eligibility criteria: Inclusion Criteria :

* active (\> 2 hrs/week physical activity)
* adult
* non smoking volunteers

Exclusion Criteria :

* cardiac, respiratory, neuromuscular, metabolic pathology

Primary outcomes:
measure: SpO2
timeFrame: mean over 1 minute
Secondary outcomes:
measure: peripheral HbO2/DeoxyHb
timeFrame: 1 min
measure: cardiac output
timeFrame: mean over 1 min
measure: pattern of breathing (fR, VT, PETCO2)
timeFrame: 1 min
Other outcomes:
Locations:
city: La Tronche
country: France
facility: CHU de Grenoble
state: Isere
Study officials:
affiliation: University Hospital, Grenoble
name: Bernard Wuyam, MD, PhD
role: PRINCIPAL_INVESTIGATOR
affiliation: Institut National de la Santé Et de la Recherche Médicale, France
name: Samuel Vergès, PhD
role: STUDY_DIRECTOR
affiliation: Université Joseph Fourier
name: Hugo NESPOULET, MsC
role: STUDY_CHAIR
References:
Clinical trial NCT01259128: Study to Investigate the Safety and Pharmacokinetics of SER120 Nasal Spray in Elderly Patients With Nocturia
Official title: A Phase III Randomized, Open-Label, Multicenter Study to Investigate the Safety and Pharmacokinetics of SER120 Nasal Spray Formulations in Elderly Patients (≥ 75 Years Old) With Nocturia
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE3
Conditions: Nocturia
Lead sponsor: Serenity Pharmaceuticals, Inc.
Sponsor class: INDUSTRY
First posted: 2010-12-13
Enrollment: 32
Sex: ALL
Minimum age (years): 75
Maximum age (years): 95
Standard ages: OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The purpose of this study is to determine if SER120 nasal spray is well tolerated in 75 years or older nocturic patients.

Detailed description: Patients entering the study are randomized to either Level 1 SER120 nasal spray concentration or Level 2 SER120 nasal spray concentration

Eligibility criteria: Inclusion Criteria:

* Male \& female greater or equal to 75 years of age, history of nocturia

Exclusion Criteria:

* CHF, Diabetes, Diabetes Insipidus, Renal Insufficiency, Heptatic Insufficiency, Incontinence, Illness requiring steroid, current or past urologic maliganancy, nephrotic syndrome
* Unexplained pelvic masses
* Urinary bladder surgery or radiotherapy
* Sleep apnea

Primary outcomes:
measure: Serum Sodium Levels at Baseline and During Treatment
timeFrame: baseline, Day 4, Day 8, Day 15, Day 22, Day 29, Day 43 and Day 57
Secondary outcomes:
measure: Change in Mean Nocturic Episodes Per Night
timeFrame: Mean value at Week 8 minus mean value at baseline
measure: Percent of Participants With Greater or Equal to 50% Reduction in the Number of Nocturic Episodes
timeFrame: 8 weeks
Other outcomes:
Locations:
city: San Antonio
country: United States
facility: Dr. Jolene Berg
state: Texas
Study officials:
References:
Clinical trial NCT01742728: Nagasaki and Tokushima
Official title: Oxidative Stress in Community-dwelling Adults
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Periodontitis
Keywords: oxidative stress, antioxidant, periodontitis, serum immunoglobulin G
antibody titer
Lead sponsor: University of Tokushima
Sponsor class: OTHER
First posted: 2012-12-05
Enrollment: 2000
Sex: ALL
Minimum age (years): 20
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: COHORT
Time perspective: CROSS_SECTIONAL
Sampling method: NON_PROBABILITY_SAMPLE
Study population: community sample

Brief summary: we analyzed the relationship between oxidative stress, immunoglobulin G antibody titers, cytokines, and periodontitis through community-based study held in the Goto city, Japan.


Eligibility criteria: Inclusion Criteria:

more than 15 teeth

Exclusion Criteria:

less than 15 teeth

Primary outcomes:
measure: oxidative stress and periodontitis
timeFrame: participants will be followed by an expected average of 1 year.
Secondary outcomes:
Other outcomes:
Locations:
city: Nagasaki, Goto
country: Japan
facility: University of Nagasaki
Study officials:
References:
citation: Hayashida H, Kawasaki K, Yoshimura A, Kitamura M, Furugen R, Nakazato M, Takamura N, Hara Y, Maeda T, Saito T. Relationship between periodontal status and HbA1c in nondiabetics. J Public Health Dent. 2009 Summer;69(3):204-6. doi: 10.1111/j.1752-7325.2009.00122.x.
citation: Tamaki N, Yoshino F, Fukui M, Hayashida H, Yoshida A, Kitamura M, Iwasaki T, Furugen R, Kawasaki K, Nakazato M, Maeda T, Kokeguchi S, Yamamoto T, Lee MC, Ito HO, Saito T. Relationship among salivary antioxidant activity, cytokines, and periodontitis: the Nagasaki Island study. J Clin Periodontol. 2015 Aug;42(8):711-718. doi: 10.1111/jcpe.12438. Epub 2015 Aug 29.