Clinical trial NCT01950793: A Comparison Between Sonoguided Injection Corticosteroid and Hyaluronic Acid Injection in Treatment of Trigger Finger
Official title: Steroid Versus Hyaluronic Acid Ultrasound-guided Injection for Trigger Finger: A Comparative Study of Outcomes
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Trigger Finger
Keywords: Hyaluronic acid, trigger finger
Lead sponsor: Taipei Veterans General Hospital, Taiwan
Sponsor class: OTHER_GOV
First posted: 2013-09-25
Enrollment: 36
Sex: ALL
Minimum age (years): 20
Maximum age (years): 65
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The study is to compare the effect between steroid injection and Hyaluronic acid in treatment trigger finger. Using sonoguided injection technique achieves more accurate injection location and therapeutic effect. We hypothesize hyaluronic acid has both lubricant and anti-inflammation effect in treatment of trigger finger, and can provide better outcome and lower adverse effect than steroid injection.

Detailed description: This is a prospective, randomized, double-blinded controlled study. Patients with the diagnosis of trigger finger will be recruited and enrolled from Taipei Veteran General Hospital PM\&R outpatient clinic. Subjects will be randomized into two groups; hyaluronic acid and triamcinolone acetonide injections, both via ultrasound-guided with one injection only.We hypothesize that through the anti-inflammatory property of the hyaluronate acid, the treatment effects will be as effective as the traditionally used steroid injections with equal or even lower recurrence rate for treatment of trigger finger. We expect that injections of hyaluronate into tendon sheath could become a new treatment option for trigger finger.

Eligibility criteria: Inclusion Criteria:

* patients with trigger digits and patients
* without previous treatment of the trigger digit

Exclusion Criteria:

* patients with prior treatment of the trigger digit (eg, splinting, injection, or therapy),
* patients less than
* 20 years old,
* patients with allergy or contraindication to hyaluronic acid,
* patients with trigger digits due to rheumatoid arthritis,
* and patients with infection at the site of injection.

Primary outcomes:
measure: Quinnell classification
timeFrame: Pre-injection; 3-weeks and 3-months post-injections
Secondary outcomes:
measure: hand functional evaluation
timeFrame: Pre-injection; 3-weeks and 3-months post-injections
measure: visual analog scale
timeFrame: Pre-injection; 3-weeks and 3-months post-injections
measure: total active motion (TAM)
timeFrame: Pre-injection; 3-weeks and 3-months post-injections
measure: grip strength
timeFrame: Pre-injection; 3-weeks and 3-months post-injections
Other outcomes:
Locations:
city: Taipei
country: Taiwan
facility: Taipei Veterans General Hospital
Study officials:
affiliation: Taipei Veterans General Hospital, Taiwan
name: Chung-Lan Kao, MD, PhD
role: STUDY_CHAIR
References:
citation: Liu DH, Tsai MW, Lin SH, Chou CL, Chiu JW, Chiang CC, Kao CL. Ultrasound-Guided Hyaluronic Acid Injections for Trigger Finger: A Double-Blinded, Randomized Controlled Trial. Arch Phys Med Rehabil. 2015 Dec;96(12):2120-7. doi: 10.1016/j.apmr.2015.08.421. Epub 2015 Sep 1.