Clinical trial NCT00539461: Non-interventional Observational Study of Pramipexole in Restless Legs Syndrome: Impact on Quality of Life
Official title: Sifrol® (Pramipexole) Impact on RLS Related Quality of Life: A 12-weeks Observational Study in Patients With Primary RLS
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Restless Legs Syndrome
Lead sponsor: Boehringer Ingelheim
Sponsor class: INDUSTRY
First posted: 2007-10-04
Enrollment: 2023
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: RLS patients

Brief summary: In this German non-interventional observational study 1980 patients diagnosed with Restless Legs Syndrome (RLS) will be investigated by 990 General Practitioners across all federal states in Germany. Both moderate to severe RLS patients, with or without previous RLS treatment, suffering from RLS symptoms like a desire to move the extremities usually associated with some discomfort, motor restlessness and worsening of symptoms at rest with at least temporary relief by activity, worsening of symptoms later in the day or at night, are eligible for this study, if it is planned to initiate therapy with pramipexole or to add pramipexole to a previously given, insufficient therapy. Three visits are planned to be documented in this PMS study, one baseline visit, visit two after the end of pramipexole titration and visit three after 12 weeks of treatment. Evaluations and visits are to be carried out and documented only if part of routine medical practice. The main goal of observational studies is to determine how pramipexole treatment works when applied in actual practice and thus maximise external validity. In actual practice patients who have been excluded in the clinical registration trials of PPX in moderate to severe primary RLS (i.e. those with certain disease histories, co-morbidities and/or demographic characteristics) will be treated with PPX. Thus in addition during this observational study information on the efficacy and safety of PPX in those patients will be obtained. The objectives of this PMS study are:

* To evaluate the treatment effect of pramipexole on RLS severity and general improvement as measured by IRLS and CGI-I.
* To evaluate quality of life of RLS patients as measured by the Restless Legs Syndrome Quality of Life questionnaire (RLS-QoL).
* To evaluate the safety profile of PPX in a natural study population.


Eligibility criteria: Inclusion Criteria:

1. Diagnosis of primary RLS
2. Indication for RLS treatment with Sifrol® (pramipexole)
3. Male or female patients aged at least 18 years.

Exclusion Criteria:

1. Any contraindications according to the Summary of Product Characteristics (SPC): hypersensitivity to pramipexole or to any of the excipients.
2. Ongoing treatment with Sifrol® (pramipexole).

Primary outcomes:
measure: Change from baseline in IRLS total score after 12 weeks
timeFrame: 12 weeks
measure: CGI-I responder rate after 12 weeks
timeFrame: 12 weeks
measure: Time to reach maintenance dose
timeFrame: 12 weeks
measure: Change from baseline in RLS-QoL total score after 12 weeks
timeFrame: 12 weeks
Secondary outcomes:
measure: Change from baseline in IRLS score after 1-4 weeks
timeFrame: 4 weeks
measure: Change in IRLS items after 12 weeks
timeFrame: 12 weeks
measure: Final dose distribution
timeFrame: 12 weeks
measure: Incidence, relationship and seriousness of adverse events
timeFrame: 12 weeks
measure: Number of premature discontinuations
timeFrame: 12 weeks
Other outcomes:
Locations:
city: Aalen
country: Germany
facility: Boehringer Ingelheim Investigational Site
city: Aarbergen
country: Germany
facility: Boehringer Ingelheim Investigational Site
city: Adendorf
country: Germany
facility: Boehringer Ingelheim Investigational Site
city: Aham
country: Germany
facility: Boehringer Ingelheim Investigational Site
city: Ahaus
country: Germany
facility: Boehringer Ingelheim Investigational Site
city: Ahlen
country: Germany
facility: Boehringer Ingelheim Investigational Site
city: Ahorntal
country: Germany
facility: Boehringer Ingelheim Investigational Site
city: Aichach
country: Germany
facility: Boehringer Ingelheim Investigational Site
city: Aislingen
country: Germany
facility: Boehringer Ingelheim Investigational Site
city: Albstadt
country: Germany
facility: Boehringer Ingelheim Investigational Site
city: Aldenhoven
country: Germany
facility: Boehringer Ingelheim Investigational Site
city: Aldingen
country: Germany
facility: Boehringer Ingelheim Investigational Site
city: Alfeld
country: Germany
facility: Boehringer Ingelheim Investigational Site
city: Alpirsbach
country: Germany
facility: Boehringer Ingelheim Investigational Site
city: Alsdorf
country: Germany
facility: Boehringer Ingelheim Investigational Site
city: Altena
country: Germany
facility: Boehringer Ingelheim Investigational Site
city: Altenstadt
country: Germany
facility: Boehringer Ingelheim Investigational Site
city: Altomünster
country: Germany
facility: Boehringer Ingelheim Investigational Site
city: Alveslohe
country: Germany
facility: Boehringer Ingelheim Investigational Site
city: Amberg
country: Germany
facility: Boehringer Ingelheim Investigational Site
city: Ammerbuch
country: Germany
facility: Boehringer Ingelheim Investigational Site
city: Andernach
country: Germany
facility: Boehringer Ingelheim Investigational Site
city: Anklam
country: Germany
facility: Boehringer Ingelheim Investigational Site
city: Apolda
country: Germany
facility: Boehringer Ingelheim Investigational Site
city: Armsheim
country: Germany
facility: Boehringer Ingelheim Investigational Site
city: Arzberg
country: Germany
facility: Boehringer Ingelheim Investigational Site
city: Aschaffenburg
country: Germany
facility: Boehringer Ingelheim Investigational Site
city: Aschersleben
country: Germany
facility: Boehringer Ingelheim Investigational Site
city: Aschheim
country: Germany
facility: Boehringer Ingelheim Investigational Site
city: Attendorn
country: Germany
facility: Boehringer Ingelheim Investigational Site
city: Auerbach
country: Germany
facility: Boehringer Ingelheim Investigational Site
city: Augsburg
country: Germany
facility: Boehringer Ingelheim Investigational Site
city: Aurich
country: Germany
facility: Boehringer Ingelheim Investigational Site
city: Babensham
country: Germany
facility: Boehringer Ingelheim Investigational Site
city: Backnang
country: Germany
facility: Boehringer Ingelheim Investigational Site
city: Bad Arolsen
country: Germany
facility: Boehringer Ingelheim Investigational Site
city: Bad Berleburg
country: Germany
facility: Boehringer Ingelheim Investigational Site
city: Bad Bevensen
country: Germany
facility: Boehringer Ingelheim Investigational Site
city: Bad Düben
country: Germany
facility: Boehringer Ingelheim Investigational Site
city: Bad Dürrenberg
country: Germany
facility: Boehringer Ingelheim Investigational Site
city: Bad Dürrheim
country: Germany
facility: Boehringer Ingelheim Investigational Site
city: Bad Ems
country: Germany
facility: Boehringer Ingelheim Investigational Site
city: Bad Essen
country: Germany
facility: Boehringer Ingelheim Investigational Site
city: Bad Kreuznach
country: Germany
facility: Boehringer Ingelheim Investigational Site
city: Bad Laasphe
country: Germany
facility: Boehringer Ingelheim Investigational Site
city: Bad Langensalza
country: Germany
facility: Boehringer Ingelheim Investigational Site
city: Bad Lausick
country: Germany
facility: Boehringer Ingelheim Investigational Site
city: Bad Münstereifel
country: Germany
facility: Boehringer Ingelheim Investigational Site
city: Bad Oeynhausen
country: Germany
facility: Boehringer Ingelheim Investigational Site
city: Bad Salzungen
country: Germany
facility: Boehringer Ingelheim Investigational Site
city: Bad Schwalbach
country: Germany
facility: Boehringer Ingelheim Investigational Site
city: Bad Schwartau
country: Germany
facility: Boehringer Ingelheim Investigational Site
city: Bad Segeberg
country: Germany
facility: Boehringer Ingelheim Investigational Site
city: Bad Tennstedt
country: Germany
facility: Boehringer Ingelheim Investigational Site
city: Bad Waldsee
country: Germany
facility: Boehringer Ingelheim Investigational Site
city: Baden-Baden
country: Germany
facility: Boehringer Ingelheim Investigational Site
city: Bahrdorf
country: Germany
facility: Boehringer Ingelheim Investigational Site
city: Baltmannsweiler
country: Germany
facility: Boehringer Ingelheim Investigational Site
city: Bamberg
country: Germany
facility: Boehringer Ingelheim Investigational Site
city: Barleben
country: Germany
facility: Boehringer Ingelheim Investigational Site
city: Baunatal
country: Germany
facility: Boehringer Ingelheim Investigational Site
city: Bautzen
country: Germany
facility: Boehringer Ingelheim Investigational Site
city: Bayreuth
country: Germany
facility: Boehringer Ingelheim Investigational Site
city: Beckum
country: Germany
facility: Boehringer Ingelheim Investigational Site
city: Beeskow
country: Germany
facility: Boehringer Ingelheim Investigational Site
city: Bellheim
country: Germany
facility: Boehringer Ingelheim Investigational Site
city: Belm
country: Germany
facility: Boehringer Ingelheim Investigational Site
city: Bensheim
country: Germany
facility: Boehringer Ingelheim Investigational Site
city: Berching
country: Germany
facility: Boehringer Ingelheim Investigational Site
city: Bergfelde
country: Germany
facility: Boehringer Ingelheim Investigational Site
city: Bergheim
country: Germany
facility: Boehringer Ingelheim Investigational Site
city: Bergisch Gladbach
country: Germany
facility: Boehringer Ingelheim Investigational Site
city: Berkheim
country: Germany
facility: Boehringer Ingelheim Investigational Site
city: Berlin
country: Germany
facility: Boehringer Ingelheim Investigational Site
city: Berne
country: Germany
facility: Boehringer Ingelheim Investigational Site
city: Bernsdorf
country: Germany
facility: Boehringer Ingelheim Investigational Site
city: Betzdorf
country: Germany
facility: Boehringer Ingelheim Investigational Site
city: Biebertal
country: Germany
facility: Boehringer Ingelheim Investigational Site
city: Bielefeld
country: Germany
facility: Boehringer Ingelheim Investigational Site
city: Bienenbüttel
country: Germany
facility: Boehringer Ingelheim Investigational Site
city: Bippen
country: Germany
facility: Boehringer Ingelheim Investigational Site
city: Birkenfeld
country: Germany
facility: Boehringer Ingelheim Investigational Site
city: Birkenwerder
country: Germany
facility: Boehringer Ingelheim Investigational Site
city: Blankenhain
country: Germany
facility: Boehringer Ingelheim Investigational Site
city: Blaustein
country: Germany
facility: Boehringer Ingelheim Investigational Site
city: Blieskastel
country: Germany
facility: Boehringer Ingelheim Investigational Site
city: Bobritzsch
country: Germany
facility: Boehringer Ingelheim Investigational Site
city: Bocholt
country: Germany
facility: Boehringer Ingelheim Investigational Site
city: Bochum
country: Germany
facility: Boehringer Ingelheim Investigational Site
city: Bockenem
country: Germany
facility: Boehringer Ingelheim Investigational Site
city: Bodelshausen
country: Germany
facility: Boehringer Ingelheim Investigational Site
city: Bodenfelde
country: Germany
facility: Boehringer Ingelheim Investigational Site
city: Bodenkirchen
country: Germany
facility: Boehringer Ingelheim Investigational Site
city: Bodenwöhr
country: Germany
facility: Boehringer Ingelheim Investigational Site
city: Bodman-Ludwigshafen
country: Germany
facility: Boehringer Ingelheim Investigational Site
city: Bollendorf
country: Germany
facility: Boehringer Ingelheim Investigational Site
city: Bonn
country: Germany
facility: Boehringer Ingelheim Investigational Site
city: Bopfingen
country: Germany
facility: Boehringer Ingelheim Investigational Site
city: Borgholzhausen
country: Germany
facility: Boehringer Ingelheim Investigational Site
city: Borken
country: Germany
facility: Boehringer Ingelheim Investigational Site
city: Borna
country: Germany
facility: Boehringer Ingelheim Investigational Site
city: Bornheim
country: Germany
facility: Boehringer Ingelheim Investigational Site
city: Bottendorf
country: Germany
facility: Boehringer Ingelheim Investigational Site
city: Bottmersdorf
country: Germany
facility: Boehringer Ingelheim Investigational Site
city: Bottrop
country: Germany
facility: Boehringer Ingelheim Investigational Site
city: Bovenden
country: Germany
facility: Boehringer Ingelheim Investigational Site
city: Brake
country: Germany
facility: Boehringer Ingelheim Investigational Site
city: Brandenburg
country: Germany
facility: Boehringer Ingelheim Investigational Site
city: Brannenburg
country: Germany
facility: Boehringer Ingelheim Investigational Site
city: Braunschweig
country: Germany
facility: Boehringer Ingelheim Investigational Site
city: Brechen
country: Germany
facility: Boehringer Ingelheim Investigational Site
city: Breitenbrunn
country: Germany
facility: Boehringer Ingelheim Investigational Site
city: Bremen
country: Germany
facility: Boehringer Ingelheim Investigational Site
city: Bremerhaven
country: Germany
facility: Boehringer Ingelheim Investigational Site
city: Brensbach
country: Germany
facility: Boehringer Ingelheim Investigational Site
city: Breuberg
country: Germany
facility: Boehringer Ingelheim Investigational Site
city: Bruchköbel
country: Germany
facility: Boehringer Ingelheim Investigational Site
city: Brunsbüttel
country: Germany
facility: Boehringer Ingelheim Investigational Site
city: Buchbach
country: Germany
facility: Boehringer Ingelheim Investigational Site
city: Buckow
country: Germany
facility: Boehringer Ingelheim Investigational Site
city: Bunde
country: Germany
facility: Boehringer Ingelheim Investigational Site
city: Burgau
country: Germany
facility: Boehringer Ingelheim Investigational Site
city: Burgdorf
country: Germany
facility: Boehringer Ingelheim Investigational Site
city: Burgpreppach
country: Germany
facility: Boehringer Ingelheim Investigational Site
city: Burg
country: Germany
facility: Boehringer Ingelheim Investigational Site
city: Burtenbach
country: Germany
facility: Boehringer Ingelheim Investigational Site
city: Buttstädt
country: Germany
facility: Boehringer Ingelheim Investigational Site
city: Butzbach
country: Germany
facility: Boehringer Ingelheim Investigational Site
city: Bärnau
country: Germany
facility: Boehringer Ingelheim Investigational Site
city: Böhlen
country: Germany
facility: Boehringer Ingelheim Investigational Site
city: Bösel
country: Germany
facility: Boehringer Ingelheim Investigational Site
city: Bückeburg
country: Germany
facility: Boehringer Ingelheim Investigational Site
city: Büdelsdorf
country: Germany
facility: Boehringer Ingelheim Investigational Site
city: Büttelborn
country: Germany
facility: Boehringer Ingelheim Investigational Site
city: Cadolzburg
country: Germany
facility: Boehringer Ingelheim Investigational Site
city: Calberlah
country: Germany
facility: Boehringer Ingelheim Investigational Site
city: Calbe
country: Germany
facility: Boehringer Ingelheim Investigational Site
city: Castrop-Rauxel
country: Germany
facility: Boehringer Ingelheim Investigational Site
city: Celle
country: Germany
facility: Boehringer Ingelheim Investigational Site
city: Chemnitz
country: Germany
facility: Boehringer Ingelheim Investigational Site
city: Cochem
country: Germany
facility: Boehringer Ingelheim Investigational Site
city: Coppenbrügge
country: Germany
facility: Boehringer Ingelheim Investigational Site
city: Crimmitschau
country: Germany
facility: Boehringer Ingelheim Investigational Site
city: Crivitz
country: Germany
facility: Boehringer Ingelheim Investigational Site
city: Cuxhaven
country: Germany
facility: Boehringer Ingelheim Investigational Site
city: Dabel
country: Germany
facility: Boehringer Ingelheim Investigational Site
city: Darmstadt
country: Germany
facility: Boehringer Ingelheim Investigational Site
city: Dassow
country: Germany
facility: Boehringer Ingelheim Investigational Site
city: Datteln
country: Germany
facility: Boehringer Ingelheim Investigational Site
city: Daun
country: Germany
facility: Boehringer Ingelheim Investigational Site
city: Deggendorf
country: Germany
facility: Boehringer Ingelheim Investigational Site
city: Deidesheim
country: Germany
facility: Boehringer Ingelheim Investigational Site
city: Deining
country: Germany
facility: Boehringer Ingelheim Investigational Site
city: Delitzsch
country: Germany
facility: Boehringer Ingelheim Investigational Site
city: Demen
country: Germany
facility: Boehringer Ingelheim Investigational Site
city: Denkendorf
country: Germany
facility: Boehringer Ingelheim Investigational Site
city: Dessau
country: Germany
facility: Boehringer Ingelheim Investigational Site
city: Detmold
country: Germany
facility: Boehringer Ingelheim Investigational Site
city: Dettenheim
country: Germany
facility: Boehringer Ingelheim Investigational Site
city: Deuben
country: Germany
facility: Boehringer Ingelheim Investigational Site
city: Deutzen
country: Germany
facility: Boehringer Ingelheim Investigational Site
city: Diepholz
country: Germany
facility: Boehringer Ingelheim Investigational Site
city: Dillingen
country: Germany
facility: Boehringer Ingelheim Investigational Site
city: Dingolfing
country: Germany
facility: Boehringer Ingelheim Investigational Site
city: Dinkelsbühl
country: Germany
facility: Boehringer Ingelheim Investigational Site
city: Dinslaken
country: Germany
facility: Boehringer Ingelheim Investigational Site
city: Dissen
country: Germany
facility: Boehringer Ingelheim Investigational Site
city: Dogern
country: Germany
facility: Boehringer Ingelheim Investigational Site
city: Dollern
country: Germany
facility: Boehringer Ingelheim Investigational Site
city: Donaueschingen
country: Germany
facility: Boehringer Ingelheim Investigational Site
city: Dormagen
country: Germany
facility: Boehringer Ingelheim Investigational Site
city: Dornstetten
country: Germany
facility: Boehringer Ingelheim Investigational Site
city: Dorsten
country: Germany
facility: Boehringer Ingelheim Investigational Site
city: Dortmund
country: Germany
facility: Boehringer Ingelheim Investigational Site
city: Dreieich
country: Germany
facility: Boehringer Ingelheim Investigational Site
city: Drensteinfurt
country: Germany
facility: Boehringer Ingelheim Investigational Site
city: Dresden
country: Germany
facility: Boehringer Ingelheim Investigational Site
city: Driedorf
country: Germany
facility: Boehringer Ingelheim Investigational Site
city: Duderstadt
country: Germany
facility: Boehringer Ingelheim Investigational Site
city: Duisburg
country: Germany
facility: Boehringer Ingelheim Investigational Site
city: Dummerstorf
country: Germany
facility: Boehringer Ingelheim Investigational Site
city: Dörentrup
country: Germany
facility: Boehringer Ingelheim Investigational Site
city: Dörpen
country: Germany
facility: Boehringer Ingelheim Investigational Site
city: Düren
country: Germany
facility: Boehringer Ingelheim Investigational Site
city: Düsseldorf
country: Germany
facility: Boehringer Ingelheim Investigational Site
city: Ebergötzen
country: Germany
facility: Boehringer Ingelheim Investigational Site
city: Ebermannstadt
country: Germany
facility: Boehringer Ingelheim Investigational Site
city: Eberstadt
country: Germany
facility: Boehringer Ingelheim Investigational Site
city: Ebhausen
country: Germany
facility: Boehringer Ingelheim Investigational Site
city: Edewecht
country: Germany
facility: Boehringer Ingelheim Investigational Site
city: Edling
country: Germany
facility: Boehringer Ingelheim Investigational Site
city: Egelsbach
country: Germany
facility: Boehringer Ingelheim Investigational Site
city: Ehingen
country: Germany
facility: Boehringer Ingelheim Investigational Site
city: Eilenburg
country: Germany
facility: Boehringer Ingelheim Investigational Site
city: Eisenhüttenstadt
country: Germany
facility: Boehringer Ingelheim Investigational Site
city: Eiterfeld
country: Germany
facility: Boehringer Ingelheim Investigational Site
city: Eitorf
country: Germany
facility: Boehringer Ingelheim Investigational Site
city: Ellwangen
country: Germany
facility: Boehringer Ingelheim Investigational Site
city: Elmshorn
country: Germany
facility: Boehringer Ingelheim Investigational Site
city: Emersacker
country: Germany
facility: Boehringer Ingelheim Investigational Site
city: Emmendingen
country: Germany
facility: Boehringer Ingelheim Investigational Site
city: Emsdetten
country: Germany
facility: Boehringer Ingelheim Investigational Site
city: Enger
country: Germany
facility: Boehringer Ingelheim Investigational Site
city: Enkenbach-Alsenborn
country: Germany
facility: Boehringer Ingelheim Investigational Site
city: Ennepetal
country: Germany
facility: Boehringer Ingelheim Investigational Site
city: Ennigerloh
country: Germany
facility: Boehringer Ingelheim Investigational Site
city: Eppstein
country: Germany
facility: Boehringer Ingelheim Investigational Site
city: Erding
country: Germany
facility: Boehringer Ingelheim Investigational Site
city: Erftstadt
country: Germany
facility: Boehringer Ingelheim Investigational Site
city: Erkrath
country: Germany
facility: Boehringer Ingelheim Investigational Site
city: Erligheim
country: Germany
facility: Boehringer Ingelheim Investigational Site
city: Erndtebrück
country: Germany
facility: Boehringer Ingelheim Investigational Site
city: Erolzheim
country: Germany
facility: Boehringer Ingelheim Investigational Site
city: Eschborn
country: Germany
facility: Boehringer Ingelheim Investigational Site
city: Eschelbronn
country: Germany
facility: Boehringer Ingelheim Investigational Site
city: Eschweiler
country: Germany
facility: Boehringer Ingelheim Investigational Site
city: Eslohe
country: Germany
facility: Boehringer Ingelheim Investigational Site
city: Espenhain
country: Germany
facility: Boehringer Ingelheim Investigational Site
city: Essen
country: Germany
facility: Boehringer Ingelheim Investigational Site
city: Esslingen
country: Germany
facility: Boehringer Ingelheim Investigational Site
city: Euskirchen
country: Germany
facility: Boehringer Ingelheim Investigational Site
city: Filderstadt
country: Germany
facility: Boehringer Ingelheim Investigational Site
city: Floh-Seligenthal
country: Germany
facility: Boehringer Ingelheim Investigational Site
city: Flöha
country: Germany
facility: Boehringer Ingelheim Investigational Site
city: Forbach
country: Germany
facility: Boehringer Ingelheim Investigational Site
city: Forchheim
country: Germany
facility: Boehringer Ingelheim Investigational Site
city: Frankenberg
country: Germany
facility: Boehringer Ingelheim Investigational Site
city: Frankenthal
country: Germany
facility: Boehringer Ingelheim Investigational Site
city: Frankfurt
country: Germany
facility: Boehringer Ingelheim Investigational Site
city: Freiberg
country: Germany
facility: Boehringer Ingelheim Investigational Site
city: Freiburg
country: Germany
facility: Boehringer Ingelheim Investigational Site
city: Freigericht
country: Germany
facility: Boehringer Ingelheim Investigational Site
city: Freudenstadt
country: Germany
facility: Boehringer Ingelheim Investigational Site
city: Freyung
country: Germany
facility: Boehringer Ingelheim Investigational Site
city: Friedland
country: Germany
facility: Boehringer Ingelheim Investigational Site
city: Friedrichshafen
country: Germany
facility: Boehringer Ingelheim Investigational Site
city: Friedrichsthal
country: Germany
facility: Boehringer Ingelheim Investigational Site
city: Frohburg
country: Germany
facility: Boehringer Ingelheim Investigational Site
city: Fulda
country: Germany
facility: Boehringer Ingelheim Investigational Site
city: Furtwangen
country: Germany
facility: Boehringer Ingelheim Investigational Site
city: Fürstenwalde
country: Germany
facility: Boehringer Ingelheim Investigational Site
city: Füssen
country: Germany
facility: Boehringer Ingelheim Investigational Site
city: Gangelt
country: Germany
facility: Boehringer Ingelheim Investigational Site
city: Gardelegen
country: Germany
facility: Boehringer Ingelheim Investigational Site
city: Garmisch-Partenkirchen
country: Germany
facility: Boehringer Ingelheim Investigational Site
city: Gars
country: Germany
facility: Boehringer Ingelheim Investigational Site
city: Gaußig
country: Germany
facility: Boehringer Ingelheim Investigational Site
city: Gebesee
country: Germany
facility: Boehringer Ingelheim Investigational Site
city: Geesthacht
country: Germany
facility: Boehringer Ingelheim Investigational Site
city: Gelbensande
country: Germany
facility: Boehringer Ingelheim Investigational Site
city: Gelsenkirchen
country: Germany
facility: Boehringer Ingelheim Investigational Site
city: Gensingen
country: Germany
facility: Boehringer Ingelheim Investigational Site
city: Georgsmarienhütte
country: Germany
facility: Boehringer Ingelheim Investigational Site
city: Gera
country: Germany
facility: Boehringer Ingelheim Investigational Site
city: Gerbstedt
country: Germany
facility: Boehringer Ingelheim Investigational Site
city: Germaringen
country: Germany
facility: Boehringer Ingelheim Investigational Site
city: Germering
country: Germany
facility: Boehringer Ingelheim Investigational Site
city: Germersheim
country: Germany
facility: Boehringer Ingelheim Investigational Site
city: Gevelsberg
country: Germany
facility: Boehringer Ingelheim Investigational Site
city: Gießen
country: Germany
facility: Boehringer Ingelheim Investigational Site
city: Gifhorn
country: Germany
facility: Boehringer Ingelheim Investigational Site
city: Gilserberg
country: Germany
facility: Boehringer Ingelheim Investigational Site
city: Gladbeck
country: Germany
facility: Boehringer Ingelheim Investigational Site
city: Gleichen
country: Germany
facility: Boehringer Ingelheim Investigational Site
city: Gochsheim
country: Germany
facility: Boehringer Ingelheim Investigational Site
city: Goch
country: Germany
facility: Boehringer Ingelheim Investigational Site
city: Gomaringen
country: Germany
facility: Boehringer Ingelheim Investigational Site
city: Grafenau
country: Germany
facility: Boehringer Ingelheim Investigational Site
city: Gransee
country: Germany
facility: Boehringer Ingelheim Investigational Site
city: Grassau
country: Germany
facility: Boehringer Ingelheim Investigational Site
city: Greiz
country: Germany
facility: Boehringer Ingelheim Investigational Site
city: Greven
country: Germany
facility: Boehringer Ingelheim Investigational Site
city: Grevesmühlen
country: Germany
facility: Boehringer Ingelheim Investigational Site
city: Griesheim
country: Germany
facility: Boehringer Ingelheim Investigational Site
city: Gronau
country: Germany
facility: Boehringer Ingelheim Investigational Site
city: Groß Grönau
country: Germany
facility: Boehringer Ingelheim Investigational Site
city: Groß Quenstedt
country: Germany
facility: Boehringer Ingelheim Investigational Site
city: Groß-Zimmern
country: Germany
facility: Boehringer Ingelheim Investigational Site
city: Großalmerode
country: Germany
facility: Boehringer Ingelheim Investigational Site
city: Großbottwar
country: Germany
facility: Boehringer Ingelheim Investigational Site
city: Großefehn
country: Germany
facility: Boehringer Ingelheim Investigational Site
city: Großhabersdorf
country: Germany
facility: Boehringer Ingelheim Investigational Site
city: Großkorbetha
country: Germany
facility: Boehringer Ingelheim Investigational Site
city: Großlangheim
country: Germany
facility: Boehringer Ingelheim Investigational Site
city: Grömitz
country: Germany
facility: Boehringer Ingelheim Investigational Site
city: Grünbach
country: Germany
facility: Boehringer Ingelheim Investigational Site
city: Gummersbach
country: Germany
facility: Boehringer Ingelheim Investigational Site
city: Göllheim
country: Germany
facility: Boehringer Ingelheim Investigational Site
city: Göllingen
country: Germany
facility: Boehringer Ingelheim Investigational Site
city: Göttingen
country: Germany
facility: Boehringer Ingelheim Investigational Site
city: Güstrow
country: Germany
facility: Boehringer Ingelheim Investigational Site
city: Haag
country: Germany
facility: Boehringer Ingelheim Investigational Site
city: Hagen
country: Germany
facility: Boehringer Ingelheim Investigational Site
city: Haigerloch
country: Germany
facility: Boehringer Ingelheim Investigational Site
city: Haldensleben
country: Germany
facility: Boehringer Ingelheim Investigational Site
city: Halle
country: Germany
facility: Boehringer Ingelheim Investigational Site
city: Hamburg
country: Germany
facility: Boehringer Ingelheim Investigational Site
city: Hamminkeln
country: Germany
facility: Boehringer Ingelheim Investigational Site
city: Hamm
country: Germany
facility: Boehringer Ingelheim Investigational Site
city: Hanau
country: Germany
facility: Boehringer Ingelheim Investigational Site
city: Hanerau-Hademarschen
country: Germany
facility: Boehringer Ingelheim Investigational Site
city: Hannover
country: Germany
facility: Boehringer Ingelheim Investigational Site
city: Harpstedt
country: Germany
facility: Boehringer Ingelheim Investigational Site
city: Harsefeld
country: Germany
facility: Boehringer Ingelheim Investigational Site
city: Harsewinkel
country: Germany
facility: Boehringer Ingelheim Investigational Site
city: Haselünne
country: Germany
facility: Boehringer Ingelheim Investigational Site
city: Hattersheim
country: Germany
facility: Boehringer Ingelheim Investigational Site
city: Hattingen
country: Germany
facility: Boehringer Ingelheim Investigational Site
city: Havixbeck
country: Germany
facility: Boehringer Ingelheim Investigational Site
city: Hedersleben
country: Germany
facility: Boehringer Ingelheim Investigational Site
city: Heek
country: Germany
facility: Boehringer Ingelheim Investigational Site
city: Heidelberg
country: Germany
facility: Boehringer Ingelheim Investigational Site
city: Heide
country: Germany
facility: Boehringer Ingelheim Investigational Site
city: Heilbronn
country: Germany
facility: Boehringer Ingelheim Investigational Site
city: Heimsheim
country: Germany
facility: Boehringer Ingelheim Investigational Site
city: Heinsberg
country: Germany
facility: Boehringer Ingelheim Investigational Site
city: Hellenthal
country: Germany
facility: Boehringer Ingelheim Investigational Site
Study officials:
References: