Clinical trial NCT06829680: Investigation of the Effects of Pilates Training Combined with Whole Body Vibration on Balance and Mobility in Individuals with Multiple Sclerosis
Official title: Investigation of the Effects of Pilates Training Combined with Whole Body Vibration on Balance and Mobility in Individuals with Multiple Sclerosis
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Multiple Sclerosis
Keywords: Balance
Multiple Sclerosis
Mobility
Pilates
Vibration
Lead sponsor: Gazi University
Sponsor class: OTHER
First posted: 2025-02-17
Enrollment: 34
Sex: ALL
Minimum age (years): 18
Maximum age (years): 65
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: SUPPORTIVE_CARE

Brief summary: The aim of this study is to investigate the effects of Pilates training combined with whole-body vibration (WBV) on balance and mobility in individuals with Multiple Sclerosis (MS). The main questions it aims to answer are:

* Are the improvements in core stability, lower limb functional muscle strength, balance and mobility obtained with Pilates training combined with WBV (Pilates-WBV) in individuals with MS greater than with Pilates training alone?
* Are the improvements in upper extremity performance and fatigue obtained with Pilates-WBV training in individuals with MS greater than with Pilates training alone?

Researchers will compare Pilates-WBV training with a group that received Pilates training alone to see if there is any additional benefit.

Participants will:

* Take Pilates-WBV or Pilates training twice a week for 6 weeks
* Be evaluated with pre- and post-training


Eligibility criteria: Inclusion Criteria:

* Definitive Multiple Sclerosis diagnosed by a specialist
* Expanded Disability Status Scale (EDSS) score between 0-5
* Accepting participation in the study voluntarily

Exclusion Criteria:

* An MS attack within the last three months
* Pregnancy
* Endoprosthesis or electronic implant
* A cardiovascular, pulmonary or orthopedic disease
* A disease that can affect the immune system, such as infection or cancer
* Additional neurological disease

Primary outcomes:
measure: The Activities-specific Balance Confidence Scale
timeFrame: From enrollment to the end of treatment at 6 weeks
measure: The Five Times Sit-to-Stand Test
timeFrame: From enrollment to the end of treatment at 6 weeks
measure: The Timed Up and Go Test
timeFrame: From enrollment to the end of treatment at 6 weeks
measure: The 6-Minute Walk Test
timeFrame: From enrollment to the end of treatment at 6 weeks
measure: The Limits of Stability Test
timeFrame: From enrollment to the end of treatment at 6 weeks
measure: The Postural Stability Test
timeFrame: From enrollment to the end of treatment at 6 weeks
measure: The Modified Sensory Organization Test
timeFrame: From enrollment to the end of treatment at 6 weeks
measure: The Side-bridge Test
timeFrame: From enrollment to the end of treatment at 6 weeks
measure: The Biering-Sorensen Test
timeFrame: From enrollment to the end of treatment at 6 weeks
measure: The Trunk Flexor Test
timeFrame: From enrollment to the end of treatment at 6 weeks
measure: The Prone Bridge Test
timeFrame: From enrollment to the end of treatment at 6 weeks
measure: The Sit-ups Test
timeFrame: From enrollment to the end of treatment at 6 weeks
measure: The Modified Push-ups Test
timeFrame: From enrollment to the end of treatment at 6 weeks
Secondary outcomes:
measure: The Nine-Hole Peg Test
timeFrame: From enrollment to the end of treatment at 6 weeks
measure: The Fatigue Severity Scale
timeFrame: From enrollment to the end of treatment at 6 weeks
measure: The Fatigue Impact Scale
timeFrame: From enrollment to the end of treatment at 6 weeks
Other outcomes:
Locations:
city: Ankara
country: Turkey
facility: Gazi University, Faculty of Health Science, Department of Physiotherapy and Rehabilitation
Study officials:
affiliation: Gazi University
name: Arzu GUCLU GUNDUZ, Professor Doctor
role: PRINCIPAL_INVESTIGATOR
References:
citation: Abbasi M, Kordi Yoosefinejad A, Poursadeghfard M, Parsaei Jahromi F, Motealleh A, Sobhani S. Whole body vibration improves core muscle strength and endurance in ambulant individuals with multiple sclerosis: A randomized clinical trial. Mult Scler Relat Disord. 2019 Jul;32:88-93. doi: 10.1016/j.msard.2019.04.028. Epub 2019 Apr 30.