louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT04622488: The Effect of Diclofenac Potassium Insitu Gel Vs Calcium Hydroxide as Intra-canal Medications on Post-operative Pain and Anti-bacterial Effect
Official title: The Effect of Diclofenac Potassium Insitu Gel Versus Calcium Hydroxide as Intra-canal Medications on Post-operative Pain and Anti-bacterial Effect in Lower Non Vital Premolars With Symptomatic Apical Periodontitis
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Post Operative Pain
Keywords: Calcium Hydroxide
Diclofenac potassium
Intra-canal Medications
Lead sponsor: Cairo University
Sponsor class: OTHER
First posted: 2020-11-10
Enrollment: 44
Sex: ALL
Minimum age (years): 18
Maximum age (years): 45
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The aim of this study is to clinically compare the post-operative pain level and antibacterial effect when using the Diclofenac Potassium Insitu gel versus calcium hydroxide as an intra- canal medication in patients with apical periodontitis.


Eligibility criteria: Inclusion Criteria:

* Age between 18-45 years old.
* Males/Females.
* Lower permanent premolars with: Non-Vital pulps. Sensitive to percussion. Negative response to cold pulp tester (ethyl chloride spray1). Apical periodontitis
* Systemically healthy patients (ASA I or II).

Exclusion Criteria:

* Medically compromised patients having significant systemic disorders. (ASA III or IV).

  * History of intolerance to NSAIDS.
  * Patients with two or more adjacent teeth requiring endodontic treatment.
  * Teeth with :
* Association with swelling or fistulous tract.
* Acute or chronic peri-apical abscess. Mobility Grade II or III.
* Pocket depth more than 5mm.
* Previous root canal therapy.
* Non-restorability
* Patients with a contraindication for the use of DFK or those known to be allergic to any of the study medications.eg. Patient with kidney problems.

Primary outcomes:
measure: Incidence of Post operative pain assessed by VAS
timeFrame: 72 hours
Secondary outcomes:
measure: Antibacterial effectiveness by measuring the bacterial count.
timeFrame: pre-operatively(S1), after chemo-mechanical preparation(S2), and after 1 week(S3).
Other outcomes:
Locations:
city: Cairo
country: Egypt
facility: Faculty of Dentistry Cairo University
state: El- Manial
Study officials:
References:
Clinical trial NCT04326088: Postoperative Complication After Free Flap Reconstruction for Head and Neck Cancer
Official title: The Impact of Operation Time and Operators on Postoperative Complication After Free Flap Reconstruction for Patients With Head and Neck Cancer
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Head and Neck Cancer
Recurrent Cancer
Surgery--Complications
Lead sponsor: Chang Gung Memorial Hospital
Sponsor class: OTHER
First posted: 2020-03-30
Enrollment: 2004
Sex: ALL
Minimum age (years): 20
Maximum age (years): 100
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: CASE_CONTROL
Time perspective: RETROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: 2,004 patients with head and neck cancer who underwent tumor wide excision and primary free flap reconstruction or secondary free flap reconstruction between March 2008 and February 2017. After excluding missing or unvalidated data, 1,700 patients with a total of 1,791 free flap reconstructions (21 patients received double free flap reconstructions) was left in the study.

Brief summary: This study was designed to investigate the outcome of free-flap reconstruction surgery following head and neck cancer resection between primary and recurrent head and neck cancer patients.


Eligibility criteria: Inclusion Criteria:

* Patients with head and neck cancer who underwent tumor wide excision and primary free flap reconstruction or secondary free flap reconstruction between March 2008 and February 2017
* Age: 20\~100 years old

Exclusion Criteria:

* patients with missing or unvalidated data
* patients less than 20 years old

Primary outcomes:
measure: Failure or success flap
timeFrame: 2 months after surgery
Secondary outcomes:
measure: Complications
timeFrame: 2 months after surgery
Other outcomes:
Locations:
city: Kaohsiung
country: Taiwan
facility: Kaohsiung Chang Gung Memorial Hospital
Study officials:
References:
Clinical trial NCT05711888: Semantic Recognition Task (SRT) in Alzheimer Disease
Official title: A Sensitive Measurement Proposal in Alzheimer's Disease: Semantic Recognition Task
Study type: INTERVENTIONAL
Overall status: RECRUITING
Phase: NA
Conditions: Alzheimer Disease
Keywords: Alzheimer Disease
Recognition
Semantic
Memory
Free and Cued Selective Reminding Test
Lead sponsor: Istanbul University
Sponsor class: OTHER
First posted: 2023-02-03
Enrollment: 80
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: NA
Intervention model: SINGLE_GROUP
Intervention model description: Semantic recognition task outcomes are observed in people diagnosed with Alzheimer's disease with Non-Alzheimer population.
Primary purpose: DIAGNOSTIC

Brief summary: The goal of this study is to observe the outcomes of a semantic recognition task in Alzheimer Disease and discuss what this might add to clinical practice.

Detailed description: In classical memory testing procedures, the outcomes of recognition task is related to hippocampal memory deficits knowing that the recognition task is not purely temporal lobe activity. The aim of this study is to propose a recognition task more specific to temporal lobe activity.

Eligibility criteria: Inclusion Criteria:

* to have biomarker analysis for Alzheimer disease (positive or negative).

Exclusion Criteria:

* illiteracy

Primary outcomes:
measure: Semantic Recognition Task
timeFrame: 1 day
Secondary outcomes:
Other outcomes:
Locations:
city: Beşiktaş
country: Turkey
facility: Jbid Dursun Uncu
state: İstanbul
Study officials:
affiliation: Istanbul University
name: İ. Hakan Gürvit, Prof. MD.
role: STUDY_DIRECTOR
References:
Clinical trial NCT01506388: A Novel Protocol for Labour Induction
Official title: Foley Catheter Plus Vaginal Isosorbide Mononitrate Versus Vaginal Misoprostol for Induction of Labour:a Randomised Controlled Trial
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE3
Conditions: Failed Induction of Labor
Keywords: labour induction
Foley catheter
misoprostol
isosorbide mononitrate
Lead sponsor: Cairo University
Sponsor class: OTHER
First posted: 2012-01-10
Enrollment: 400
Sex: FEMALE
Minimum age (years): 18
Maximum age (years): 40
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The use of foley catheter was tested many times and proved to be effective for induction of labour.

Detailed description: The investigators compare between vaginal misoprostol versus foley catheter plus vaginal isosorbide mononitrate (IMN) for induction of labour

Eligibility criteria: Inclusion Criteria:

* Term or post term pregnancies.
* Live,singleton fetus.
* Cephalic presentation.
* Intact membrane.
* Bishop score \< 6.
* Not in labour.
* Medically indicated for labour induction.
* Primigravida or parity of 3 or less.

Exclusion Criteria:

* Previous caesarean delivery.
* Malpresentation.
* Placenta previa.
* Sever intrauterine growth restriction.
* Multiple pregnancy.
* Polyhydramnios.
* Oligohydramnios.
* Bishop score 7 or more.

Primary outcomes:
measure: caesarean section rate
timeFrame: 1 year
Secondary outcomes:
measure: time from induction to delivery
timeFrame: 1 year
Other outcomes:
Locations:
city: Cairo
country: Egypt
facility: Cairo University
city: Cairo
country: Egypt
facility: Waleed El-khayat
Study officials:
affiliation: Cairo University
name: Waleed El-khayat, M.D.
role: STUDY_DIRECTOR
References:
citation: El-Khayat W, Alelaiw H, El-kateb A, Elsemary A. Comparing vaginal misoprostol versus Foley catheter plus vaginal isosorbide mononitrate for labor induction. J Matern Fetal Neonatal Med. 2016;29(3):487-92. doi: 10.3109/14767058.2015.1007036. Epub 2015 Feb 19.
Clinical trial NCT04133688: Mobile App in Addiction
Official title: A Mobile App for the Self Quantification of Sleep and Behaviors : a Pilot Study With Teenagers and Young Adults
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Addiction
Keywords: mobile app, pilot study, addiction, sleep, ePRO
Lead sponsor: Assistance Publique - Hôpitaux de Paris
Sponsor class: OTHER
First posted: 2019-10-21
Enrollment: 36
Sex: ALL
Minimum age (years): 12
Maximum age (years): 18
Standard ages: CHILD
ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: SUPPORTIVE_CARE

Brief summary: The sleep and behavior agendas are today very largely underused while they can be of a considerable contribution in the follow-up of the patients and the reinforcement of the therapeutic alliance. In the management of addictions, sleep disorders are a major comorbidity, these two components maintain indeed complex links: it was highlighted a bidirectional relationship between the effect of the consumption of addictive substances on sleep and conversely, the effect of sleep disorders on the consumption of products, the same is true for overexposure to screens.

Detailed description: The sleep and behavior agendas are today very largely underused while they can be of a considerable contribution in the follow-up of the patients and the reinforcement of the therapeutic alliance. In the management of addictions, sleep disorders are a major comorbidity, these two components maintain indeed complex links: it was highlighted a bidirectional relationship between the effect of the consumption of addictive substances on sleep and conversely, the effect of sleep disorders on the consumption of products, the same is true for overexposure to screens.

Eligibility criteria: Inclusion Criteria:

* Teenagers or young adults from 12 to 18 years old (included)
* Consultant for addiction to cannabis and / or tobacco and / or alcohol and / or screen
* Treated within the Functional Unit of addictology
* For minors, after parental consent

Exclusion Criteria:

-

Primary outcomes:
measure: Number of days filled for sleep and consumptions, usable by the doctor on the day of the consultation / after 15 days of self-evaluation required by the treatment
timeFrame: 15 days
Secondary outcomes:
Other outcomes:
Locations:
city: Paris
country: France
facility: Robert Debre Hospital
Study officials:
affiliation: APHP
name: Benjamin Pitrat, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT03088488: Vitamin D and Periodontitis
Official title: Relationship of Bone Metabolism Biomarkers and Serum 25-Hydroxy Vitamin D in Patients With Chronic Periodontitis
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Alveolar Bone Loss
Keywords: 25-OH vitamin D
RANKL
Osteoprotogerin
TNF-α
Lead sponsor: T.C. ORDU ÜNİVERSİTESİ
Sponsor class: OTHER
First posted: 2017-03-23
Enrollment: 60
Sex: ALL
Minimum age (years): 25
Maximum age (years): 45
Standard ages: ADULT
Accepts healthy volunteers: yes
Observational model: CASE_CONTROL
Time perspective: CROSS_SECTIONAL
Sampling method: PROBABILITY_SAMPLE
Study population: Sixty patients (35 girls) who were aged between 25-45 years (30.8 (mean) ± 4.9 (standard deviation) and presented to our faculty for periodontal and other dental problems, participated in the study.

Subjects were divided in to 2 groups each containing 30 patients:

* Group I - periodontal healthy
* Group II - untreated chronic periodontitis (radiographic evidence of bone loss and clinical attachment loss in excess of 5 mm in more than six teeth)

Brief summary: Vitamin D has become important for periodontal disease due to play a role in autoimmunity, bone mineral metabolism and inflammation. Our aim was to investigate the relation between serum 25-hydroxy vitamin D levels, clinical periodontal parameters and blood serum biomarkers. The subjects were evaluated in 2 groups as chronic periodontitis (n= 30) and periodontally healthy subjects (n= 30). Periodontal parameters and fasting venous blood samples were taken from the subjects to assess each patient's periodontal status and for biochemical analyses (25-hydroxy vitamin D (25-OH vit D), osteoprotegerin (OPG), receptor activator of nuclear kappa B ligand (RANKL), C-telopeptide (CTx), tumor necrosis factor-α (TNF-α)).


Eligibility criteria: * Inclusion Criteria:

  * never-smokers
  * no history of systemic disease
  * no patients had been under periodontal therapy and medicine for at least 6 months before the study
  * no pregnancy or lactation
  * no alcohol or antioxidant vitamin consumption.
* Exclusion Criteria:

  * -

Primary outcomes:
measure: Biochemical parameters
timeFrame: Baseline
measure: Biochemical parameters
timeFrame: Baseline
measure: Biochemical parameters
timeFrame: Baseline
measure: Biochemical parameters
timeFrame: Baseline
measure: Biochemical parameters
timeFrame: Baseline
Secondary outcomes:
measure: Periodontal parameters
timeFrame: Baseline
measure: Periodontal parameters
timeFrame: Baseline
measure: Periodontal parameters
timeFrame: Baseline
measure: Periodontal parameters
timeFrame: Baseline
Other outcomes:
Locations:
Study officials:
References:
Clinical trial NCT02582788: Bathing Additives in Pediatric Atopic Dermatitis
Official title: Bathing Additives in Management of Pediatric Atopic Dermatitis
Study type: INTERVENTIONAL
Overall status: TERMINATED
Phase: NA
Conditions: Dermatitis, Atopic
Lead sponsor: Mayo Clinic
Sponsor class: OTHER
First posted: 2015-10-21
Enrollment: 10
Sex: ALL
Minimum age (years): 6
Maximum age (years): 17
Standard ages: CHILD
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The current clinical guidelines for management of atopic dermatitis now recommend bleach baths. This requires simply the addition of regular household bleach to twice-weekly baths. At the Mayo Clinic, dilute acetic acid (vinegar) has been recommended for decades in wet wraps to treat patients hospitalized for their atopic dermatitis. However, this practice has not been widely adopted in the pediatric dermatology community. Will the use of dilute acetic acid (vinegar) in twice weekly baths help manage atopic dermatitis in pediatric patients as well as, or better than, the current accepted guidelines?


Eligibility criteria: Inclusion Criteria:

1. Patients from 6 months to 17 years of age
2. Currently residing in US.
3. Follow up visits at 1 month, 3 months and 6 months after initiation of treatment in study (Figure 1).
4. Last follow-up at 1 year in clinic or via written mailed-out survey.
5. Diagnosis of atopic dermatitis AND

   1. Have active signs of bacterial skin infection OR
   2. Any documented suspected history of bacterial skin infection (weeping, crusting, and/or pustules on exam), OR
   3. Prescription for oral antibiotics for skin infection in the past 6 months from any provider). OR
   4. Have been prescribed bleach baths as part of an atopic dermatitis skin care regimen.

Exclusion Criteria:

1. Superficial skin infection without diagnosis of atopic dermatitis
2. Lack of in-clinic follow up assessment at 6 months

Primary outcomes:
measure: EASI score at 6 months
timeFrame: 6 months
Secondary outcomes:
measure: Courses of antibiotics required
timeFrame: 1 year
Other outcomes:
Locations:
city: Rochester
country: United States
facility: Mayo Clinic in Rochester
state: Minnesota
Study officials:
affiliation: Mayo Clinic
name: Megha Tollefson, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT04365088: Evaluation of the Effects of Pre-operative Deflazacort on Post-operative Pain, Edema and Trismus
Official title: Evaluation of the Effects of Pre-operative Deflazacort on Post-operative Pain, Edema and Trismus in Impacted Lower Third Molar Surgery
Study type: INTERVENTIONAL
Overall status: ACTIVE_NOT_RECRUITING
Phase: PHASE4
Conditions: Impacted Third Molar Tooth
Keywords: deflazacort
pain
edema
trismus
Lead sponsor: Yuzuncu Yıl University
Sponsor class: OTHER
First posted: 2020-04-28
Enrollment: 35
Sex: ALL
Minimum age (years): 18
Maximum age (years): 40
Standard ages: ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: FACTORIAL
Primary purpose: PREVENTION

Brief summary: Removal of impacted lower third molar teeth is one of the most common oral surgical procedures, and these operations often lead to various complications in patients. Antibiotics, analgesics and/or anti-inflammatory drugs are prescribed for the treatment of complications encountered. Anti-inflammatory is the property of a substance or treatment that reduces inflammation or swelling. Anti-inflammatory drugs make up about half of analgesics, remedying pain by reducing inflammation as opposed to opioids, which affect the central nervous system to block pain signaling to the brain. Based on this information, in this study, it is aimed to evaluate the effects of deflazacort preoperatively on the postoperative pain, swelling and trismus.


Eligibility criteria: Inclusion Criteria:

* absence of any systemic disease,
* having bilateral impacted mandibular third molar teeth in a similar position
* absence of allergy to any of the drugs used in the study,
* absence of pregnancy/lactating state,
* no history of any medication use during at least 2 week before the operation.

Exclusion Criteria:

* not regularly coming to the controls,
* not using their medicines regularly,
* using any additional medication that may affect the outcome of the study

Primary outcomes:
measure: Postoperative Pain
timeFrame: Postoperative 1st day
measure: Postoperative Pain
timeFrame: Postoperative 2nd day
measure: Postoperative Edema
timeFrame: Postoperative 2nd day
measure: Postoperative Trismus
timeFrame: Postoperative 2nd day
measure: Postoperative Pain
timeFrame: Postoperative 3d day
measure: Postoperative Pain
timeFrame: Postoperative 4th day
measure: Postoperative Pain
timeFrame: Postoperative 5th day
measure: Postoperative Pain
timeFrame: Postoperative 6th day
measure: Postoperative Pain
timeFrame: Postoperative 7th day
measure: Postoperative Edema
timeFrame: Postoperative 7th day
measure: Postoperative Trismus
timeFrame: Postoperative 7th day
Secondary outcomes:
Other outcomes:
Locations:
city: Van
country: Turkey
facility: Van Yuzuncu Yil University, Faculty of Dentistry
state: Tuşba
Study officials:
References:
Clinical trial NCT06242288: Correlation Between Depression Scores and Serum NF-ĸB/NLRP3 Axis, Biotinidase, and HMGB After Treatment With Isotretinoin in Patients With Acne Vulgaris
Official title: Correlation Between Depression Scores and Serum NF-ĸB/NLRP3 Axis, Biotinidase, and HMGB After Treatment With Isotretinoin in Patients With Acne Vulgaris
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE3
Conditions: Acne Vulgaris
Lead sponsor: Tanta University
Sponsor class: OTHER
First posted: 2024-02-05
Enrollment: 40
Sex: ALL
Minimum age (years): 18
Maximum age (years): 40
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: Acne is a chronic inflammatory disease of the pilosebaceous unit resulting from androgen-induced increased sebum production, altered keratinization, inflammation, and bacterial colonization of hair follicles on the face, neck, chest, and back by, Cutibacterium acnes. Although all age groups can be affected, it is primarily a disease of adolescence. Treatment selection is based on disease severity, patient preference, and tolerability. Isotretinoin is drug of chioce used for moderate and severe acne. Isotretinoin results in a significant reduction in sebum production, influences comedogenesis, lowers surface and ductal c. acnes and has anti-inflammatory properties. Biotin deficiency may be caused by insufficient dietary uptake of biotin, drug- vitamin interactions and increased biotin catabolism during pregnancy and in smokers. Biotin deficiency can also be precipitated by decreased activities of biotinidase, which plays a central role in the intestinal absorption of biotin


Eligibility criteria: Inclusion Criteria:

Age of 19 to 35 years. Body mass index (BMI) of 18.5 to 23 kg/m2. Acne vulgaris (global acne scoring more than 18)

Exclusion Criteria:

Use of oral steroids, oral contraceptives, oral vitamin A derivatives, antibiotics, or herbal medicines that may affect the test results during the last 4 weeks.

Alcohol drinking within the last week. Smoking. Pregnancy or lactation. Judgement that physical or mental testing is not appropriate for the clinical trial.

Participation in other clinical trials that may affect this t

Primary outcomes:
measure: change in biotinidase level
timeFrame: 2 months
Secondary outcomes:
Other outcomes:
Locations:
city: Tanta
country: Egypt
facility: Tanta Unuversity
Study officials:
References:
Clinical trial NCT04194788: Olfaction Changes in Patients Undergoing Spine Surgery
Official title: Prospective Observational Pilot Study on Olfaction Alterations That Occur in Spine Patients After Surgery
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Orthopedic Disorder of Spine
Smell Disorder
Lead sponsor: I.R.C.C.S Ospedale Galeazzi-Sant'Ambrogio
Sponsor class: OTHER
First posted: 2019-12-11
Enrollment: 50
Sex: ALL
Minimum age (years): 50
Maximum age (years): 85
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Patients undergoing spine surgery.

Brief summary: This observational prospective study evaluates perioperative olfaction alterations, comprising changes in threshold value, discrimination and identification, which occur in spine patients. The single group is subjected to a preoperative and a postoperative assessment.


Eligibility criteria: Inclusion Criteria:

* Males or females
* Caucasian race
* Between 50 and 85 years of age
* Candidates to spine surgery
* Acceptance and signing of informed consent

Exclusion Criteria:

* Past or present cancer
* Heart failure
* Kidney failure (III-IV)
* Past or present neuropsychiatric disorders
* Heavy smokers (over/equal 3 cigarettes per day)
* Smell disorders
* Rhinitis
* Allergies to the respiratory system

Primary outcomes:
measure: Changes in olfaction threshold
timeFrame: Day before surgery and first day after surgery
Secondary outcomes:
Other outcomes:
Locations:
city: Milan
country: Italy
facility: IRCCS Istituto Ortopedico Galeazzi
Study officials:
affiliation: IRCCS Istituto Ortopedico Galeazzi
name: Matteo Briguglio
role: PRINCIPAL_INVESTIGATOR
References: