Clinical trial NCT04137211: Acute Effects of Sitting and Physical Activity on Brain Health
Official title: Acute Effects of Sitting and Physical Activity on Cerebrovascular Circulation Among Adults
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Healthy Adults
Lead sponsor: The Swedish School of Sport and Health Sciences
Sponsor class: OTHER
Collaborators: name: The Knowledge Foundation
name: ICA-gruppen
name: Intrum AB
name: SATS
name: Monark Exercise
name: Itrim
First posted: 2019-10-23
Enrollment: 13
Sex: ALL
Minimum age (years): 40
Maximum age (years): 60
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: CROSSOVER
Primary purpose: PREVENTION

Brief summary: The specific aim of this study is to understand how a working day composed of prolonged sitting, sitting regularly interrupted by light aerobic exercise or resistance exercise affects an important mechanism underpinning healthy brain functions, namely cerebral blood flow. It is primarily focused on investigating these effects in ecologically valid conditions, i.e. activity patterns that closely resemble a typical day at the office.

Detailed description: The study will be a controlled crossover experimental trial with three conditions involving 13 adult participants aged between 40 and 60 years. Each participant will complete each of the three experimental conditions, separated by a washout period of minimum four days. As well, physical activity behaviours and sleep the day/night before the test day will be measured. The first visit will be a familiarization session. On the second, third, and fourth visits, participants will undergo three different standardized 3-hour interventions in a randomized order. Before and immediately after the three-hour interventions, blood pressure, augmentation index, and cerebral hemodynamic response of the prefrontal cortex during standardized cognitive tasks (1,2, and 3-back tests) will be measured. Additionally, saliva samples will be collected the morning of the test day and before and after the interventions, blood glucose will be assessed continuously during the trial, and fitness will be measured at the familiarization visit.

Eligibility criteria: Inclusion Criteria:

- Has a BMI under 35kg/m2

Exclusion Criteria:

* Has diabetes, epilepsy, or circulatory conditions
* Has experienced heart failure, stroke, or myocardial infarction
* Takes treatment for high blood pressure, sleep disorders, depression, or psychosis

Primary outcomes:
measure: Changes in cerebral blood flow
timeFrame: before to after 3 hour intervention
Secondary outcomes:
measure: Augmentation index
timeFrame: before to after 3 hour intervention
measure: Blood glucose levels
timeFrame: during the 3 hour intervention
measure: Cortisol
timeFrame: before to after 3 hour intervention
measure: Mood
timeFrame: before to after 3 hour intervention
measure: Sleepiness
timeFrame: before to after 3 hour intervention
measure: Cognitive performance
timeFrame: before to after 3 hour intervention
measure: Alertness
timeFrame: before to after 3 hour intervention
Other outcomes:
Locations:
city: Stockholm
country: Sweden
facility: The Swedish School of Sport and Health Sciences (GIH)
Study officials:
affiliation: The Swedish School of Sport and Health Sciences (GIH)
name: Maria Ekblom, PhD
role: PRINCIPAL_INVESTIGATOR
References:
citation: Heiland EG, Tarassova O, Fernstrom M, English C, Ekblom O, Ekblom MM. Frequent, Short Physical Activity Breaks Reduce Prefrontal Cortex Activation but Preserve Working Memory in Middle-Aged Adults: ABBaH Study. Front Hum Neurosci. 2021 Sep 16;15:719509. doi: 10.3389/fnhum.2021.719509. eCollection 2021.