louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT04235452: Electrophysiological Characteristics and Anatomical Differentiation of Epileptic and Non-epileptic Myoclonus.
Official title: Electrophysiological Characteristics and Anatomical Differentiation of Epileptic and Non-epileptic Myoclonus.
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Myoclonus
Evoked Potential
Keywords: Myoclonus, Evoked potential
Lead sponsor: Mansoura University Hospital
Sponsor class: OTHER
First posted: 2020-01-22
Enrollment: 50
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: CASE_CONTROL
Time perspective: RETROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: 50 patients with myoclonus of different etiologies (primary and secondary myoclonus).

Brief summary: This study was conducted on a series of patients with myoclonus to identify the electrophysiological characteristics and the anatomical classification of myoclonus of different causes.

Detailed description: The current study included 50 patients with different types of myoclonus in comparison to 30 control subjects. Electrophysiological study was done for all patients by Somatosensory Evoked Potential (SSEP) and Electroencephalography (EEG) while the control group underwent SSEP. SSEP was studied in the patients and control group by stimulation of right and left median nerves.

Eligibility criteria: Inclusion Criteria:

* Myoclonus classified into primary and secondary myoclonus.

Exclusion Criteria:

* Psychiatric comorbidity to exclude psychological myoclonus.

Primary outcomes:
measure: Somatosensory evoked potential
timeFrame: 24-72 hours
Secondary outcomes:
Other outcomes:
Locations:
city: Mansoura
country: Egypt
facility: Mansoura University Hospital
state: Dakahlia
Study officials:
affiliation: Assistant Prof of Neurology
name: Esmael Ahmed, MD
role: PRINCIPAL_INVESTIGATOR
References:
citation: Abdo WF, van de Warrenburg BP, Burn DJ, Quinn NP, Bloem BR. The clinical approach to movement disorders. Nat Rev Neurol. 2010 Jan;6(1):29-37. doi: 10.1038/nrneurol.2009.196.
citation: Agarwal P, Frucht SJ. Myoclonus. Curr Opin Neurol. 2003 Aug;16(4):515-21. doi: 10.1097/01.wco.0000084231.82329.9c.
citation: Alvarez, V. & Rossetti, A. O. 2015. Electroencephalography and Evoked Potentials: Technical Background. Clinical Neurophysiology in Disorders of Consciousness. Springer. 7-23.
Clinical trial NCT02758652: Molecular Mechanisms Leading to Chemoresistance in Epithelial Ovarian Cancer
Official title: Molecular Mechanisms Leading to Chemoresistance in Epithelial Ovarian Cancer
Study type: OBSERVATIONAL
Overall status: ACTIVE_NOT_RECRUITING
Conditions: Ovarian Cancer
Keywords: chemoresistance
miRNA
microRNA
Lead sponsor: Tampere University Hospital
Sponsor class: OTHER
Collaborators: name: Tampere University
name: University of Helsinki
First posted: 2016-05-02
Enrollment: 160
Sex: FEMALE
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: CASE_ONLY
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Newly diagnosed epithelial ovarian cancer patients operated inTampere University Hospital, Finland.

Brief summary: Epithelial ovarian cancer is the most lethal gynecological malignancy in developed countries and the fifth most common cause of cancer-related death in women. Poor prognosis is due to challenges in early diagnosis and development of inevitable resistance to chemotherapy in majority of patients despite of good initial treatment response. The purpose of this prospective study is to analyze variation in microRNA expression in prediction of primary treatment response and the role of microRNAs in development of chemoresistance in epithelial ovarian cancer.

• Objectives: To screen microRNAs from prospectively collected plasma, urine and tumor samples from patients diagnosed with epithelial ovarian cancer. Samples are analyzed for microRNA expression and differential expression is correlated with primary treatment response, progression-free survival and overall survival.

• Methods: Plasma, urine and tumor samples are collected at primary surgery (open surgery or diagnostic laparoscopy) or interval debulking surgery, at 1st, 3rd and 6th neoadjuvant or adjuvant chemotherapy and at progression for high-throughput screening of microRNA expression by array technology.

Detailed description: Inclusion criteria:

patients operated for a suspected ovarian malignancy in the Department of Obstetrics and Gynecology in Tampere University Informed consent obtained

Eligibility criteria: Inclusion Criteria:

* 18 years of age, informed consent.

Exclusion Criteria:

* Informed consent not provided, age under 18 years.

Primary outcomes:
measure: miRNA expression profile as measured by miRNA array
timeFrame: 5 years
Secondary outcomes:
measure: Progression-free survival
timeFrame: 5 years
measure: Over-all survival
timeFrame: 5 years
Other outcomes:
Locations:
city: Tampere
country: Finland
facility: Tampere University Hospital
Study officials:
affiliation: Chief of Gynecological Oncology
name: Annika Auranen, adj prof
role: PRINCIPAL_INVESTIGATOR
References:
citation: Savolainen K, Scaravilli M, Ilvesmaki A, Staff S, Tolonen T, Maenpaa JU, Visakorpi T, Auranen A. Expression of the miR-200 family in tumor tissue, plasma and urine of epithelial ovarian cancer patients in comparison to benign counterparts. BMC Res Notes. 2020 Jul 1;13(1):311. doi: 10.1186/s13104-020-05155-6.
Clinical trial NCT01183052: Mitochondrial Dysfunction and Oxidative Stress in Chronic Obstructive Pulmonary Disease (COPD) Patients
Official title: Mitochondrial Respiratory Chain and Peripheral Muscle Dysfunction in COPD Patients
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: COPD Patients
Keywords: COPD
exercise tolerance
oxidative stress
Lead sponsor: 5 Santé
Sponsor class: OTHER
Collaborators: name: Centre Hospitalier Régional Universitaire Montpellier
name: Institut National de la Santé Et de la Recherche Médicale, France
First posted: 2010-08-17
Enrollment: 30
Sex: ALL
Minimum age (years): 50
Maximum age (years): 75
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP

Brief summary: The purpose of this study is to understand the underlying mechanisms of improved exercise tolerance in COPD patients after training program.

Detailed description: Training protocol used is based on recommendations (Nici et al., 2006) and was previously used in our group (Varray et al., 1991; Vallet et al., 1997). A minimum of 20 sessions in 4-6 weeks were proposed. The exercise intensity of exercise corresponds to target heart rate at ventilatory threshold measured during incremental exercise test. Training at this intensity allowed us to individualize effort for each patient.

Eligibility criteria: Inclusion Criteria:

* Sedentary mild to severe COPD patients

Exclusion Criteria:

* Neuromuscular disease
* Chronic heart failure
* Renal diseases
* Liver diseases
* Obesity

Primary outcomes:
measure: Cellular effects of exercise training at the ventilatory threshold intensity
timeFrame: 6 to 8 weeks
Secondary outcomes:
Other outcomes:
Locations:
city: Lodeve
country: France
facility: Clinique du Souffle La Vallonie
city: Osseja
country: France
facility: Clinique du Souffle la Solane
Study officials:
affiliation: Institut National de la Santé Et de la Recherche Médicale, France
name: Maurice MH Hayot, MCU-PH
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT03437252: Physical Activity in Chronic Obstructive Pulmonary Disease(COPD) Acute Exacerbation Patients
Official title: The Association of Physical Activity With Readmission Due to Exacerbation in COPD Patients
Study type: OBSERVATIONAL
Overall status: ENROLLING_BY_INVITATION
Conditions: COPD Exacerbation
Keywords: Chronic obstructive pulmonary disease
Chronic obstructive pulmonary disease acute exacerbation
Physical activity
Wearable arm device
Lead sponsor: Samsung Medical Center
Sponsor class: OTHER
First posted: 2018-02-19
Enrollment: 86
Sex: ALL
Minimum age (years): 40
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: CASE_CROSSOVER
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Based on COPD patients who visited Samsung medical center.

Brief summary: Patients who are suffering from Chronic Obstructive Pulmonary Disease (COPD) had a decreased level of physical activity which is consequentially related to another acute exacerbation event. In this study, we selected patients from those who were admitted for acute exacerbation of COPD, evaluated physical activity by accelerometer (wearable multisensory armband devices) to find out the correlation between physical activity in COPD acute exacerbation patients.


Eligibility criteria: Inclusion Criteria:

* COPD patient who have forced expiratory volume in one second/ forced vital capacity (FEV1/FVC) \< 70% by spirometry and those who have not been admitted for acute exacerbation in recent 3 months

Exclusion Criteria:

* Those who does not consent or those who have drug addiction, psycho-socially or medically not feasible to this study

Primary outcomes:
measure: Re admission rate after COPD acute exacerbation
timeFrame: 13 weeks
Secondary outcomes:
Other outcomes:
Locations:
city: Seoul
country: Korea, Republic of
facility: Samsung medical center
Study officials:
References:
Clinical trial NCT04375852: Tyrosine Hydroxylase Antibody Levels in Autoimmune Polyglandular Syndrome Type 1 Associated Keratitis
Official title: Tyrosine Hydroxylase Antibody Levels in Autoimmune Polyglandular Syndrome Type 1 Associated Keratitis
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Autoimmune Polyglandular Syndrome Type I
Autoimmune Keratitis
Keywords: Tyrosine hydroxylase
Autoantibodies
Autoimmune Polyglandular Syndrome
Lead sponsor: The Eye Center and The Eye Foundation for Research in Ophthalmology
Sponsor class: OTHER
First posted: 2020-05-05
Enrollment: 16
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: SCREENING

Brief summary: Tyrosine hydroxylase autoantibodies impair sympathetic innervation leading to keratitis. In this study, the investigators have shown the significant association between severity of keratitis and presence of tyrosine hydroxylase autoantibodies.

Detailed description: Sixteen consecutive cases diagnosed with APS-1associated keratitis were included in this study. Each patient underwent complete ophthalmologic examination. Blood was obtained from each patient for testing the endocrine functions and determination of a panel of autoantibodies to the following: Side-chain cleavage enzyme (SSC), Aromatic L-amino acid decarboxylase (AADC), Tryptophan hydroxylase (TPH),Tyrosine hydroxylase ( TH), 17 α-hydroxylase (17α-OH), Cytochrome P450 1A2 (CYP1A2), 21-hydroxylase (21-OH), Potassium channel regulatory protein (KCNRG), Tyrosine phosphatase-like protein IA-2 (IA-2), Glutamic acid decarboxylase 65 (GAD65), NACT Leucine-Rich-Repeat-Protein 5 (NALP5), and Interleukin (IL) 22.

Eligibility criteria: Inclusion Criteria:

* consecutive patients diagnosed with APS-1associated keratitis

Exclusion Criteria:

* None

Primary outcomes:
measure: To report the correlation between autoantibodies with the severity keratitis in patients Autoimmune polyglandular syndrome type 1 (APS-1).
timeFrame: 3 months
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
References:
Clinical trial NCT00300352: Effect of Folic Acid Treatment in Coronary Artery Disease
Official title: Effect of Folic Acid Treatment in Coronary Artery Disease
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: PHASE2
Conditions: Coronary Artery Disease
Keywords: Coronary artery disease
Folic acid
Endothelial function
Lead sponsor: University of Oxford
Sponsor class: OTHER
Collaborators: name: British Heart Foundation
First posted: 2006-03-08
Enrollment: 60
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: PREVENTION

Brief summary: We seek to examine the effects of folic acid treatment on vascular function in patients with coronary artery disease. Our hypothesis is that folic acid treatment will improve vascular function

Detailed description: Common vascular disease states including diabetes and atherosclerosis are associated with endothelial dysfunction, characterised by reduced bioactivity of nitric oxide (NO). Folates are thought to improve endothelial function,but the mechanism by which this effect occurs is poorly understood. We propose to study the effects of folate supplementation on endothelial function in patients with coronary artery disease.

Eligibility criteria: Inclusion Criteria:

Clinical diagnosis of coronary artery disease

Exclusion Criteria:

Recent acute coronary event Renal and/or hepatic dysfunction Metallic implants

Primary outcomes:
measure: Improvement in noninvasive measures of vascular function
Secondary outcomes:
measure: Improvement in laboratory measures of vascular function
Other outcomes:
Locations:
city: Oxford
country: United Kingdom
facility: University of Oxford
Study officials:
affiliation: University of Oxford
name: Keith Channon, MD FRCP
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT02616952: A Chinese Herbal Decoction for Stress Urinary Incontinence
Official title: Effect of Yiqi Suoquan Tang, a Chinese Herbal Decoction, on Stress Urinary Incontinence
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE2
Conditions: Urinary Incontinence, Stress
Keywords: Stress urinary incontinence
Chinese Herb
Traditional Chinese medicine
Pelvic floor muscle training
Lead sponsor: Guang'anmen Hospital of China Academy of Chinese Medical Sciences
Sponsor class: OTHER
First posted: 2015-11-30
Enrollment: 72
Sex: FEMALE
Minimum age (years): 21
Maximum age (years): 65
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The purpose of this study is to determine whether Yiqi Suoquan Tang, a Chinese Herbal decoction, is effective in the treatment of female stress urinary incontinence.

Detailed description: The pilot randomized, controlled trial is aimed to preliminarily assess the effectiveness of Yiqi Suoquan Tang, a Chinese Herbal decoction, in the treatment of female stress urinary incontinence (SUI). Eligible participants will be randomly allocated to receiving Yiqi Suoquan Tang or pelvic floor muscle training (PFMT) using a random number generator in a 1:1 ratio. To minimize the evaluation bias, the outcome assessors and statisticians will be masked to treatment allocation.

Assuming a two-sided alpha of 0.05, power of 90%, and a 20% drop-out, a sample size of 36 would be needed for each group. The statistical analysis will be performed based on the intention-to-treat principle, which is defined as patients that have received at least one treatment. Missing data will be replaced by the last observed value. Continuous variables will be compared by Student t test or Mann-Whitney U test; categorical variables will be analyzed by chi-square test, Fisher's exact test or Kruskal-Wallis H test as appropriate. For comparison between two time points, paired t-test or Wilcoxon signed rank test will be used as appropriate. A statistically significant difference was set at P\<0.05.

Eligibility criteria: Inclusion Criteria:

* Clinical diagnosis of stress urinary incontinence
* Must be able to swallow Chinese hebal decoction

Exclusion Criteria:

* Urinary tract infection
* Neurogenic bladder
* Pelvic organ prolapse \> stage 2
* Overactive bladder
* Previous anti-incontinence surgery
* Post-void residual urine volume (PVR) \> 100ml.

Primary outcomes:
measure: Change in 24h pad testing
timeFrame: 12 weeks
Secondary outcomes:
measure: Change in ICIQ-SF questionnaire
timeFrame: 12 weeks
measure: Change in abdominal leak-point pressure
timeFrame: 12 weeks
measure: Change in I-QOL questionnaire
timeFrame: 12 weeks
Other outcomes:
measure: Adverse events
timeFrame: 12 weeks
Locations:
city: Beijing
country: China
facility: Guang'anmen Hospital, China Academy of Chinese Medical Sciences
state: Beijing
Study officials:
affiliation: Guang'anmen hospital
name: Ran Pang, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT00005352: Chronic Stress as a Risk Factor in the Etiology of Coronary Heart Disease
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Cardiovascular Diseases
Coronary Disease
Heart Diseases
Lead sponsor: National Heart, Lung, and Blood Institute (NHLBI)
Sponsor class: NIH
First posted: 2000-05-26
Sex: MALE
Maximum age (years): 100
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no

Brief summary: To conduct a prospective, longitudinal, analysis of the psychophysiological effects of chronic exposure to environmental stress. The study took advantage of a unique, naturally occurring experiment caused by the relocation of a major international airport.

Detailed description: DESIGN NARRATIVE:

Studies were conducted on blood pressure and the neuroendocrine effects of noise resulting from the relocation of the Munich International Airport. At the former airport site the investigators monitored people exposed to high levels of noise and then tracked these same individuals as their ambient environment became normal following the shutdown of the airport. At the new airport site, the opposite situation occurred: Individuals living in normal, quiet ambient conditions became exposed to loud aircraft noise. At both sites, control groups were formed who were not exposed to aircraft noise. The study piggybacked onto a German sponsored grant. NIH funds covered the costs of cardiovascular and psycho-physiological data analysis. Measures included biochemical assays of chronic neuroendocrine markers of stress, resting blood pressure, and reactivity of blood pressure during cognitive tasks. Perceptions of community noise levels were also assessed as possible mediators of the stressful effects of chronic exposure to ambient, environmental noise.

The study completion date listed in this record was obtained from the "End Date" entered in the Protocol Registration and Results System (PRS) record.

Eligibility criteria: No eligibility criteria

Primary outcomes:
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
affiliation: Cornell University
name: Gary Evans
References:
citation: Tafalla RJ, Evans GW. Noise, physiology, and human performance: the potential role of effort. J Occup Health Psychol. 1997 Apr;2(2):148-55. doi: 10.1037//1076-8998.2.2.148.
citation: Bullinger M, Hygge S, Evans GW, Meis M, von Mackensen S. The psychological cost of aircraft noise for children. Zentralbl Hyg Umweltmed. 1999 Aug;202(2-4):127-38.
citation: Hygge S, Evans GW, Bullinger M. A prospective study of some effects of aircraft noise on cognitive performance in schoolchildren. Psychol Sci. 2002 Sep;13(5):469-74. doi: 10.1111/1467-9280.00483.
Clinical trial NCT06773052: The Experience, Perceptions and Unexpressed Needs of Heart and Lung Transplant Patients Admitted to Intensive Care
Official title: The Experience, Perceptions and Unexpressed Needs of Heart and Lung Transplant Patients Admitted to Intensive Care: a Qualitative, Descriptive Phenomenological Observational Study
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Heart and Lung Transplants
Lead sponsor: IRCCS Azienda Ospedaliero-Universitaria di Bologna
Sponsor class: OTHER
First posted: 2025-01-14
Enrollment: 21
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Observational model: OTHER
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: The total sample consisted of 21 patients who underwent heart or lung transplants. Of these, 18 patients (86%) had undergone heart transplants, while 3 patients (14%) had undergone lung transplants.

Brief summary: Qualitative descriptive phenomenological study aimed to investigate the experience, perceptions and unexpressed needs of patients undergoing heart and lung transplantation admitted to intensive care unit through semi-structured interviews

Detailed description: It was conduct a qualitative phenomenological study which, through semi-structured interviews to investigate the experience , the perceptions and the unexpressed needs of patients undergoing heart and lung transplants within the specific context of " High Intensity Cardio-Thoraco-Vascular Hospitalization" of the IRCCS University Hospital of Bologna. The study aims at helping nurses to provide more adequate care, in order to meet the individual needs of patients and describe the meaning and essence of the hospitalization experience, through the in-depth analysis of the specific words pronounced by the patients themselves.

Below are the questions that guided the research:

What is the general experience of the intensive care patients? What are the experiences, the perceptions and the unexpressed needs of these patients in relation to their hospitalization in intensive care?

Eligibility criteria: Inclusion Criteria:

* able to understand and communicate in Italian
* transferred from intensive to sub-intensive care unit
* not affected by cognitive disorders
* who provides informed consent to the study

Exclusion Criteria:

* none

Primary outcomes:
measure: Experience, perceptions and unexpressed needs of heart and lung transplant patients
timeFrame: through study completion, an average of 1 year
Secondary outcomes:
Other outcomes:
Locations:
city: Bologna
country: Italy
facility: IRCCS Azienda Ospedaliero-Universitaria di Bologna
Study officials:
affiliation: IRCCS Azienda Ospedaliero-Universitaria di Bologna
name: Nikita Valentina Ugenti, MD
role: PRINCIPAL_INVESTIGATOR
References: