Clinical trial NCT04444492: Combination of Ranibizumab and Targeted Laser Photocoagulation
Official title: Long-term Need of Ranibizumab Injections With or Without Early Targeted Peripheral Laser Photocoagulation for Treatment of Macular Edema Due to Central Retinal Vein Occlusion
Study type: INTERVENTIONAL
Overall status: RECRUITING
Phase: PHASE3
Conditions: Central Retinal Vein Occlusion With Macular Edema
Keywords: retinal vein occlusion
Lead sponsor: University of Giessen
Sponsor class: OTHER
Collaborators: name: University of Leipzig
First posted: 2020-06-23
Enrollment: 110
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: Intravitreal injections of Ranibizumab will be applied in all patients according to treatment guidelines. The experimental group will receive additional targeted laser photocoagulation of the peripheral areas of capillary non-perfusion (up to 4 laser treatments within 1st year of the study). Based on the long-term observation after CoRaLa I study an importantly shorter duration of treatment and a relevant reduction of the total number of re-injections in RL patients is expected.

Detailed description: Retinal vein occlusion (RVO) is the second most common retinal vascular disease leading to visual impairment. Main cause for visual impairment in CRVO (Central Retinal Vein Occlusion) is macular edema (ME) while neovascularization of the retina and/or the anterior segment is the most serious complication leading to vitreous hemorrhage, retinal detachment and neovascular glaucoma. In serious cases loss of vision is imminent. To date, no causal treatment has been proven to be effective in large trials. Intravitreal injections of drugs that inhibit the vascular endothelial growth factor (VEGF) and other inflammatory factors are the current treatments of choice for ME due to CRVO. Two different anti-VEGF drugs (ranibizumab and aflibercept), and a biodegradable dexamethasone implant are approved by the EMA (European Medicines Agency). Based on data from confirmatory studies anti-VEGF-drugs are recommended as a treatment of first choice in patients with RVO. All intravitreal drugs provide only a temporary effect with need for re-treatment for recurrences of ME. Mean number of ranibizumab application needed in CRVO patients was found to be 7.4 to 10.2 injections in 12 months. A significant number of CRVO patients require treatment over several years. Need for repetitive treatments and ophthalmic controls are a major burden for patients (and their relatives who are required for driving the patients to ophthalmologists) despite of only few adverse events and generally well-tolerated injections. Endophthalmitis is the most severe ocular complication which can be eye-sight-threatening. The more injections are administered, the higher is the cumulative risk of complications. Due to high costs (\>1000 € per injection) treatment with repeated injections over years is of significant socio-economic importance, too. Therefore, treatments concepts which would lead to permanent reduction of ME and/or significantly reduce the number of re-injections over long-term periods are the major currently unmet need in patients with RVO.

Until now, several studies evaluated the impact of the additional pan-retinal laser photocoagulation in patients undergoing the anti-VEGF-treatment for the ME due to retinal vein occlusions. However, most of the studies are limited by retrospective design, small number of evaluated patients or lack of the randomization. None of the available prospective randomized studies had sufficient power to finally clarify the benefit of the additional laser treatment. Therefore, there is an unmet need for a large randomized, prospective, multicentric trials.

The proposed study will be the first sufficiently powered trial evaluating the long-term effect of targeted laser photocoagulation performed selectively (targeted) in peripheral areas of non-perfusion in combination with standard anti-VEGF treatment (ranibizumab injections) on the duration of the required intravitreal treatment over time period of 2 years.

Eligibility criteria: Inclusion Criteria:

* Diagnosis of macular edema due to central retinal vein occlusion foveal thickness \> 250 μm (measured by OCT)
* Age \> 18 years
* Written informed consent of the patient
* BCVA score in the study eye between 24 letters (20/320) and 78 letters (20/25) measured in ETDRS chart
* History of CRVO no longer than 6 months
* Presence of capillary non-perfusion in peripheral retina larger than 5 disc areas documented in ultra wide-field fluorescein angiography
* Ability and willingness to attend all scheduled visits and assessments

Exclusion Criteria:

* CRVO with ischemic maculopathy defined as diameter of the foveolar avascular zone larger than 2 optic disc diameters
* Macular edema due to another etiology than retinal vein occlusion (e.g. diabetic maculopathy, uveitis, age related macular degeneration, Irvine-Gass syndrome)
* History of idiopathic central serous chorioretinopathy
* Presence of vitreoretinal interface disease (e.g. vitreomacular traction, epiretinal membrane), either on clinical examination or in OCT
* An eye that, in the investigator's opinion, would not benefit from resolution of macular edema, such as eyes with foveal atrophy, dense pigmentary changes, or dense subfoveal hard exudates
* Aphakia in the study eye
* Scatter laser photocoagulation or macular photocoagulation in the study eye prior to study entry
* Intraocular or periocular injection of steroids in the study eye prior to study entry
* Previous use of an anti-VEGF drug in the study eye
* Cataract surgery or any other intraocular surgery in the study eye within 3 months prior to study entry
* Uncontrolled glaucoma (defined as intraocular pressure ≥ 30 mm Hg despite treatment with maximal anti-glaucoma medications)
* History of stroke, myocardial infarction, transient ischemic attacks within 3 months prior to the study
* Pregnancy (positive urine pregnancy test) or lactation
* The presence of active malignancy, including lymphoproliferative disorders.
* History of allergy to fluorescein or any component of the ranibizumab formulation
* Active intraocular infection
* Participation in another simultaneous interventional medical investigation or trial
* Women with child bearing potency without effective contraception (i. e. implants, injectables, combined oral contraceptives, some IUDs or vasectomised partner) during the conduct of the trial.

Primary outcomes:
measure: Efficacy endpoint is the time to treatment success
timeFrame: up-to 29 months
Secondary outcomes:
measure: Best corrected visual acuity (BCVA)
timeFrame: Month 29
measure: Central subfield thickness (CST)
timeFrame: Month 29
measure: Number of ranibizumab injections
timeFrame: Month 29
Other outcomes:
measure: Development of neovascularization(s)
timeFrame: Month 24
measure: The area of non-perfusion
timeFrame: Month 24
measure: Vessel density
timeFrame: Month 24
measure: Potential visual field loss
timeFrame: Month 4 and Month 24
measure: The number of laser treatments and the laser spots given in the experimental group (RL-arm).
timeFrame: Month 24
measure: Health-related quality of life (QoL): Visual Function Questionnaire VFQ25
timeFrame: Baseline, Month 12 and Month 24
measure: Areal of foveal avascular zone
timeFrame: Month 24
Locations:
city: Innsbruck
country: Austria
facility: Medizinische Universität Innsbruck, Klinik für Augenheilkunde und Optometrie
city: Dresden
country: Germany
facility: Universitätsklinikum Carl Gustav Carus Dresden Klinik und Polyklinik für Augenheilkunde
city: Düsseldorf
country: Germany
facility: Internationale Innovative Ophthalmochirurgie GbR, Klinik für Augenchirurgie
city: Freiburg
country: Germany
facility: Universitätsklinikum Klinik für Augenheilkunde Freiburg
city: Gießen
country: Germany
facility: Universitätsklinikum Gießen, Klinik und Poliklinik für Augenheilkunde
city: Hannover
country: Germany
facility: Hannover MHH Universitätsklinik für Augenheilkunde
city: Leipzig
country: Germany
facility: University Hospital of Leipzig Department of Ophthalmology
city: Ludwigshafen
country: Germany
facility: Klinikum der Stadt Ludwigshafen Augenklinik
city: Marburg
country: Germany
facility: Universitätsklinikum Gießen und Marburg GmbH, Standort Marburg Klinik für Augenheilkunde
city: München
country: Germany
facility: Ludwig-Maximilians-Universität München, Augenklinik
city: Münster
country: Germany
facility: Augenzentrum am St. Franziskus-Hospital Münster
city: Münster
country: Germany
facility: Universitätsklinikum Klinik für Augenheilkunde
city: Tübingen
country: Germany
facility: Universitätsklinikum Tübingen, Department für Augenheilkunde
city: Ulm
country: Germany
facility: Universitätsklinikum Ulm, Klinik für Augenheilkunde
city: Zschopau
country: Germany
facility: Augen-OP-Zentrum Zschopau, Praxis für Augenheilkunde
Study officials:
affiliation: Department of Ophthalmology Justus-Liebig-Universität Giessen
name: Matus Rehak, Professor
role: STUDY_DIRECTOR
References: