louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT01685307: Impact of Cooking Process on Meat Protein Digestion and Metabolism
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Physiology
Digestive Tract
Heating Process
Keywords: ileal digestibility
metabolism
stable isotopes
Lead sponsor: Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement
Sponsor class: OTHER
Collaborators: name: National Research Agency, France
First posted: 2012-09-14
Enrollment: 48
Sex: ALL
Minimum age (years): 18
Maximum age (years): 45
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: BASIC_SCIENCE

Brief summary: Few is known on meat protein digestibility in humans and the impact of cooking process, while excessive intake of processed meat has been suggested to increase the risk of colorectal cancer.

This study aims to measure in vivo in humans the real digestibility of beef meat proteins depending 2 cooking processes, using ileal tubes and stable isotopes.


Eligibility criteria: Inclusion Criteria:

* Healthy
* BMI between 18 an 27
* Age between 18 and 45 years

Exclusion Criteria:

* Gastrointestinal or liver pathology
* Diabetes
* Pregnancy
* Vegetarian

Primary outcomes:
measure: protein digestibility
timeFrame: single measure
Secondary outcomes:
measure: nitrogen metabolism
timeFrame: single measure
Other outcomes:
Locations:
city: Bobigny
country: France
facility: Centre de Recherche sur volontaires
Study officials:
affiliation: INRA AgroParisTech
name: Claire Gaudichon, PhD
role: STUDY_DIRECTOR
References:
citation: Oberli M, Marsset-Baglieri A, Airinei G, Sante-Lhoutellier V, Khodorova N, Remond D, Foucault-Simonin A, Piedcoq J, Tome D, Fromentin G, Benamouzig R, Gaudichon C. High True Ileal Digestibility but Not Postprandial Utilization of Nitrogen from Bovine Meat Protein in Humans Is Moderately Decreased by High-Temperature, Long-Duration Cooking. J Nutr. 2015 Oct;145(10):2221-8. doi: 10.3945/jn.115.216838. Epub 2015 Aug 19.
Clinical trial NCT04181307: A Randomized Trial of a BE-EHR Module to Guide the Care of Older Adults With Diabetes
Official title: A Randomized Trial of a BE-EHR Module to Guide the Care of Older Adults With Diabetes
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Diabetes
Lead sponsor: NYU Langone Health
Sponsor class: OTHER
Collaborators: name: National Institute on Aging (NIA)
First posted: 2019-11-29
Enrollment: 7630
Sex: ALL
Minimum age (years): 75
Standard ages: OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: This RCT will test a new electronic health record module to improve guideline-compliant care of older adults with diabetes. The module incorporates effective behavioral economics (BE) principles to improve the degree to which care of older adults is compliant with Choosing Wisely (CW) guidelines; this generally involves less aggressive targets for HbA1c, and reductions of medications other than metformin. The implementation of the module is triggered by patient scheduling and medication prescribing in EPIC. The BE principles include suggesting alternatives to medications, requiring justification, setting of appropriate default order sets, and incorporation of anchoring and checklists to guide behavior.


Eligibility criteria: Inclusion Criteria:

* Patient at NYULH primary care or endocrinology practice
* Practices that have patients aged 75 or older
* Practices that have a diagnosis of diabetes in the EHR chart

Exclusion Criteria:

• Under age 75

Primary outcomes:
measure: Number of Participants Who Are CW-Compliant and CW-Noncompliant
timeFrame: Month 18
Secondary outcomes:
measure: Number of Total Prescription Encounters
timeFrame: Month 18
Other outcomes:
Locations:
city: New York
country: United States
facility: NYU Langone Health
state: New York
Study officials:
affiliation: NYU Langone
name: Andrea Troxel, ScD
role: PRINCIPAL_INVESTIGATOR
References:
citation: Belli HM, Troxel AB, Blecker SB, Anderman J, Wong C, Martinez TR, Mann DM. A Behavioral Economics-Electronic Health Record Module to Promote Appropriate Diabetes Management in Older Adults: Protocol for a Pragmatic Cluster Randomized Controlled Trial. JMIR Res Protoc. 2021 Oct 27;10(10):e28723. doi: 10.2196/28723.
Clinical trial NCT07027007: Prospective Observational Analysis of Circulating Endocan Levels in Patients Presenting With Acute Diverticulitis
Official title: Prospective Observational Analysis of Circulating Endocan Levels in Patients Presenting With Acute Diverticulitis
Study type: OBSERVATIONAL
Overall status: NOT_YET_RECRUITING
Conditions: Diverticulitis
Keywords: endocan
acute diverticolitis
diverticulitis classification
Lead sponsor: IRCCS Ospedale San Raffaele
Sponsor class: OTHER
First posted: 2025-06-18
Enrollment: 60
Sex: ALL
Minimum age (years): 18
Maximum age (years): 80
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: Patients affected by acute diverticulitis in the emergency department

Brief summary: Quantify the level of endocan in blood samples collected from patients with acute diverticulitis in the emergency department. Determine if endocan levels are correlated with the severity of diverticulitis according to the WSES classification. Assess whether patients requiring emergency surgical intervention have higher endocan values compared to others.


Eligibility criteria: Inclusion Criteria:

* Patients who have signed informed consent
* Patients who are affected by acute diverticulitis after clinical evaluation and imaging (i.e. u.s. or CeCT)

Exclusion Criteria:

* Immunosuppressed patients
* Patients suffering chronic inflammatory diseases
* Patients with concomitant malignancy, cardiac, renal and haepatic failure
* History of major vascular surgery (aneurysmectomy)
* Pregnant women
* Patients participating in other studies that may interfere with the outcome of the intervention.

Primary outcomes:
measure: Endocan serum level at admission
timeFrame: The serum of the patients enrolled inthe study will be collected within two hours from emergency room registation and tested for ENDOCAN
Secondary outcomes:
measure: Predictive value of endocan in determining which patients need emergency surgery
timeFrame: Patients will undergo diverticulitis evaluations (per WSES criteria) within 3 hours of Emergency room admission and study enrollment
measure: Prognostic value of endocan in determining the risk of recurrent diveritculitis
timeFrame: From discharge after definitive tretament till 12 months follow-up
Other outcomes:
Locations:
city: Milano
country: Italy
facility: Emergency Department IRCCS San Raffaele
Study officials:
References:
Clinical trial NCT05581888: Visual Performance of Functional Intraocular Lenses in Cataracts
Official title: Visual Performance of Different Types of Functional Intraocular Lenses in Cataract Patients
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: High Myopia
Cataract
Keywords: Visual performance
Trifocal IOL
High myopic cataract
Lead sponsor: Eye & ENT Hospital of Fudan University
Sponsor class: OTHER
First posted: 2022-10-17
Enrollment: 62
Sex: ALL
Minimum age (years): 21
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: This is a prospective, multi-center, randomized comparative study. The purpose of the study is to evaluate and compare the postoperative visual outcomes and quality of vision of two diffractive trifocal intraocular lenses (IOLs) in patients with high myopic cataracts.

Detailed description: Binocular implantation of two types of trifocal IOLs was performed in patients with high myopic cataracts. Postoperative uncorrected distance (UNVA), intermediate (UIVA), near (UNVA), and best-corrected distance visual acuity (BCVA) were measured. Defocus curve, high-order aberrations, modulation transfer function curve, Strehl ratio and reading ability were compared between the two groups. The functional vision and incidence of photic phenomena were surveyed using questionnaires.

Eligibility criteria: Inclusion Criteria:

* required binocular cataract extraction
* age \> 21 years
* length of optic axis \> 26 mm

Exclusion Criteria:

* irregular corneal astigmatism \> 0.3 um;
* amblyopia; previous ocular surgery;
* ocular pathologies such as diabetic retinopathy, macular degeneration, glaucoma with field defects;
* requirements for further ocular surgery (other than Nd:YAG capsulotomy) or retinal laser treatments during the study

Primary outcomes:
measure: uncorrected distance visual acuity (UDVA)
timeFrame: one year
measure: best corrected distance visual acuity (BCVA)
timeFrame: one year
measure: uncorrected near visual acuity (UNVA)
timeFrame: one year
measure: uncorrected intermediate visual acuity (UIVA)
timeFrame: one year
Secondary outcomes:
measure: HOAs
timeFrame: three months
measure: Strehl Ratio
timeFrame: three months
measure: objective visual quality
timeFrame: three months
Other outcomes:
Locations:
city: Shanghai
country: China
facility: Eye & ENT Hospital of Fudan University
state: Shanghai
Study officials:
affiliation: Department of Ophthalmology, Eye and Ear, Nose, and Throat Hospital, Fudan University
name: Jin Yang
role: STUDY_DIRECTOR
References:
Clinical trial NCT02186288: Effect of High-flow Nasal Cannula Oxygen on Lung Volumes Determined by Electrical Impedance Tomography
Official title: Effect of High-flow Nasal Cannula Oxygen on Lung Volumes Determined by Electrical Impedance Tomography
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Critical Care
High-flow Nasal Cannula Oxygen
Electrical Impedance Tomography
End Expiratory Lung Volume
End Expiratory Lung Impedance
Diaphragmatic Ultrasound
Keywords: Critical Care
High-flow nasal cannula oxygen
Electrical impedance tomography
End expiratory lung volume
End expiratory lung impedance
Diaphragmatic ultrasound
Lead sponsor: University Hospital, Clermont-Ferrand
Sponsor class: OTHER
First posted: 2014-07-10
Enrollment: 20
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Time perspective: CROSS_SECTIONAL
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Adult ICU patients

Brief summary: Effect of High-flow nasal cannula oxygen on end-expiratory lung volumes determined by electrical impedance tomography

Detailed description: Prospective clinical study in ICU with patients requiring High-flow nasal cannula oxygen comparing lung volumes determined by electrical impedance tomography and diaphragmatic ultrasound before, during and after High-flow nasal cannula oxygen.

Duration of High-flow nasal cannula oxygen is 30 minutes.

Eligibility criteria: Inclusion Criteria:

* • Adult ICU patients requiring High-flow nasal cannula oxygen

  * Consent of patients or family
  * Arterial line

Exclusion Criteria:

* • Tracheotomized patients

  * Dressings in the thoracic area

Primary outcomes:
measure: End-expiratory lung volume (EELV) determined by electrical impedance tomography before NIV non invasive ventilation
timeFrame: at day 1
measure: End-expiratory lung volume (EELV) determined by electrical impedance tomography during NIV non invasive ventilation
timeFrame: at day 1
measure: End-expiratory lung volume (EELV) determined by electrical impedance tomography after NIV non invasive ventilation
timeFrame: at day 1
Secondary outcomes:
measure: Anterior, medio-anterior, medio-posterior and posterior EELV at each time
timeFrame: at day 1
measure: Diaphragmatic excursion and thickness determined by ultrasound
timeFrame: at day 1
measure: Ventilatory frequency
timeFrame: at day 1
Other outcomes:
Locations:
city: Clermont-Ferrand
country: France
facility: CHU Clermont-Ferrand
Study officials:
affiliation: University Hospital, Clermont-Ferrand
name: Sébastien PERBET
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT01973088: Screening and Identification of Human Urate Transporter hURAT1 MicroRNA
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Urinary Calculi
Lead sponsor: Southwest Hospital, China
Sponsor class: OTHER
First posted: 2013-10-31
Enrollment: 80
Sex: ALL
Minimum age (years): 18
Maximum age (years): 65
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: Experiment are divided into uric acid stones group (A), non-uric acid stones group (B), control group (C), A, C recruited 30 patients each group, B group recruited 20 patients.

Brief summary: This study intends to use in patients with renal tissue and blood samples, screening and identification of renal tissue hURAT1 regulating the expression of micro-RNA, for further study of uric acid stone formation mechanism and the occurrence of clinical preventive uric acid stones provide new clues and new intervention targets.


Eligibility criteria: Inclusion Criteria:

A、B group were enrolled standards: ① aged 18-65 years old; ② comply with percutaneous nephrolithotomy lithotripsy indications for surgery; ③ ECT tips ipsilateral normal or mildly impaired renal function.

Group C patients were enrolled standards: ① aged 18-65 years old; ② normal renal function, not associated with urinary calculi in patients; ③ cancer patients met radical nephrectomy indications for surgery; ④ emergency trauma patients suffering from kidney resection surgical indications.

Exclusion Criteria:

* aged \<18 years or\> 65 years; ② neurological disease or cognitive dysfunction; ③ can not be corrected or uncorrected coagulopathy; ④ associated with diabetes, hypertension and other metabolic diseases; ⑤ accompanied by tuberculosis, hepatitis, HIV and other infectious diseases; ⑥ poor tolerance to anesthesia and surgery, such as: severe cardiopulmonary disease, coagulation disorders, etc.; ⑦ ultrasound, renal imaging examination revealed renal cortex was significantly thinner (renal cortical thickness \<1.5cm), structural variation; ⑧ with severe systemic or urinary tract infection; ⑨ ECT tips ipsilateral renal function is severely impaired or solitary kidney.

Primary outcomes:
measure: micro-RNA
timeFrame: 6 months
Secondary outcomes:
measure: Urine
timeFrame: 24 hours
measure: 24h urine quantitative analysis
timeFrame: 96 hours
measure: Blood biochemistry
timeFrame: 24 hours
measure: Stone analysis
timeFrame: 3 weeks
measure: hURAT1 transporter protein
timeFrame: 6 months
Other outcomes:
Locations:
Study officials:
References:
Clinical trial NCT02689388: Evaluating the Addition of Regional Analgesia to Reduce Postoperative Delirium in Patients Having Hip Fracture Surgery.
Official title: The Use of Post-operative Regional Analgesia Rather Than Systemic Analgesia to Decrease the Incidence of Post-operative Delirium After Acute Hip Fracture Surgery? A Prospective Randomized-controlled Double-blinded Pilot Study.
Study type: INTERVENTIONAL
Overall status: TERMINATED
Phase: NA
Conditions: Delirium
Hip Fracture
Keywords: analgesia
regional analgesia
femoral nerve block
older persons
frail
Lead sponsor: Auckland City Hospital
Sponsor class: OTHER_GOV
First posted: 2016-02-24
Enrollment: 20
Sex: ALL
Minimum age (years): 65
Standard ages: OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: PREVENTION

Brief summary: Post operative delirium is common after hip fracture surgery and is associated with increased length of hospital stay, delayed recovery and increased mortality. Postoperative delirium can also decrease a patient's quality of life and increase treatment costs. Anesthesia and pain relief (analgesia) treatments may also influence the incidence of delirium, but more research is needed into which techniques are effective in improving patient outcomes, care and decreasing costs. This pilot study compares the addition of regional analgesia as part of general anesthesia to determine the incidence of delirium following hip surgery. This is a collaborative study involving anesthesia, orthopedic surgery and geriatrics in the improvement of patient care.


Eligibility criteria: Inclusion criteria (must meet all 3):

* Greater than or equal to 65 years
* Have a hip fracture requiring surgery
* Written informed consent for participation of study prior to surgery.

Exclusion criteria:

* Contraindication to peripheral nerve block or local anaesthetics
* Unable to do delirium or cognitive testing due to language, vision or hearing impairment
* Unable to communicate with research staff due to language barriers
* History of chronic opioid use (longer than 1 month)
* Contraindication to general anesthesia

Primary outcomes:
measure: The incidence of post-operative delirium after hip fracture surgery
timeFrame: immeidately to 5 days post operatively
Secondary outcomes:
measure: Decreased recovery time after surgery
timeFrame: immediately - immediately - 90 days
measure: Decrease post-operative opioid consumption
timeFrame: immediately - immediately - 90 days
Other outcomes:
Locations:
city: Auckland
country: New Zealand
facility: Auckland City Hopsital
Study officials:
affiliation: Auckland City Hospital - Anaesthesia and Peri-Operative Medicine
name: Tin L Chiu, MBChB
role: PRINCIPAL_INVESTIGATOR
References:
citation: Guay J, Kopp S. Peripheral nerve blocks for hip fractures in adults. Cochrane Database Syst Rev. 2020 Nov 25;11(11):CD001159. doi: 10.1002/14651858.CD001159.pub3.
Clinical trial NCT02645188: Effect of Cueing on Gluteus Maximus Recruitment
Official title: Effects of Cueing on Gluteus Maximus and Hamstring Recruitment During the Bridging Exercise
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Muscle Contraction
Keywords: Electromyography
Exercise
Lead sponsor: Mayo Clinic
Sponsor class: OTHER
First posted: 2016-01-01
Enrollment: 30
Sex: FEMALE
Minimum age (years): 18
Maximum age (years): 40
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: Do specific verbal and tactile cues and instructions help people who perform bridging exercises to improve hip muscle strength to optimize recruitment of the gluteus maximus muscle?


Eligibility criteria: Inclusion Criteria:

* female
* 18-40 years of age
* normal muscle strength in lower extremities

Exclusion Criteria:

* evidence of patellofemoral pain syndrome
* evidence of femoracetabular impingement
* evidence of mechanical low back pain causing radicular (lower extremity) symptoms
* history of previous hip or knee ligament injury
* history of lower extremity trauma
* history of lower extremity surgery
* history of neurological conditions that impair motor function
* current lower extremity pain that limits functional activities

Primary outcomes:
measure: Muscle recruitment as a percentage of the maximal voluntary isometric contraction
timeFrame: 2 weeks
Secondary outcomes:
Other outcomes:
Locations:
city: Rochester
country: United States
facility: Mayo Clinic in Rochester
state: Minnesota
Study officials:
affiliation: Mayo Clinic
name: John Hollman, PhD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT00468988: Short Term Comparative Study of Xalatan With Benzalkonium Chloride vs. Travatan Z Without Benzalkonium Chloride in Healthy Volunteers
Official title: Short Term Comparative Study of Xalatan With Benzalkonium Chloride vs. Travatan Z Without Benzalkonium Chloride in Healthy Volunteers
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE4
Conditions: Glaucoma
Lead sponsor: Alcon Research
Sponsor class: INDUSTRY
First posted: 2007-05-03
Enrollment: 30
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: SINGLE_GROUP
Primary purpose: TREATMENT

Brief summary: Compare the effect of Xalatan with benzalkonium chloride on the ocular surface to those effects observed with Travatan Z without benzalkonium chloride after a single dose


Eligibility criteria: Inclusion Criteria:

* Adults with primary open-angle glaucoma, ocular hypertension or pigment dispersion glaucoma

Exclusion Criteria:

* Age

Primary outcomes:
measure: Tear Break Up Time
timeFrame: Day
Secondary outcomes:
measure: Safety
timeFrame: Onset
Other outcomes:
Locations:
city: Orlando
country: United States
facility: Orlando
state: Florida
Study officials:
affiliation: Alcon Research
name: Mark Jasek, PhD
role: STUDY_DIRECTOR
References:
Clinical trial NCT05440188: Study to Identify the Reduction of Exacerbations Resulting in Hospital Admission in Patients With COPD.
Official title: Identification of the Reduction of Exacerbations Resulting in Hospital Admission in COPD Patients After the Use of the Breath Detect Telemedicine Platform.
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: COPD Exacerbation
Keywords: telemedicine
Lead sponsor: Universidad Autonoma de Madrid
Sponsor class: OTHER
First posted: 2022-06-30
Enrollment: 80
Sex: ALL
Minimum age (years): 65
Standard ages: OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Patients from Primary Health Care, Elderly care homes, and HULP

Brief summary: identification of the reduction of exacerbations resulting in hospital admission in COPD patients after the use of the Breath Detect telemedicine platform.


Eligibility criteria: Inclusion Criteria:

* COPD diagnosed in GOLD II state or higher

Exclusion Criteria:

* Can´t read and talk in spanish

Primary outcomes:
measure: Number of hospital admissions due to exacerbations
timeFrame: 24 weeks
Secondary outcomes:
Other outcomes:
Locations:
city: Madrid
country: Spain
facility: CS Entrevías
Study officials:
References: