louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT04924556: The Effect of Rıgıd Brace on Spinopelvic Parameters and GAP Score in Adolescents With Structural Hyperkyphosis
Official title: The Effect of Rıgıd Brace on Spinopelvic Parameters and GAP Score in Adolescents With Structural Hyperkyphosis
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Hyperkyphosis, Adolescent
Scheuermann Disease
Spinal Curvatures
Keywords: Scheuermann Disease
Adolescent Hyperkyphosis
Sagittal Balance
Spinopelvic Parameters
Lead sponsor: Halic University
Sponsor class: OTHER
Collaborators: name: Medipol University
name: Başakşehir Çam & Sakura City Hospital
First posted: 2021-06-14
Enrollment: 40
Sex: ALL
Minimum age (years): 10
Maximum age (years): 18
Standard ages: CHILD
ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: 10-18 years patients with Scheuermann's kyphosis or adolescent hyperkyphosis and treated with CAD-CAM design a rigid brace

Brief summary: This study aimed to investigate the effect of rıgıd brace treatment on spinopelvic parameters and GAP score in patients with adolescent hyperkyphosis. This was a retrospective analysis of prospectively collected data. Thirty-two patients who were diagnosed with structural hyperkyphosis and treated with CAD-CAM design rigid brace were included in the study in Formed Healthcare Scoliosis Treatment and Brace Center between December 2015-2020.


Eligibility criteria: Inclusion Criteria:

* Subjects who diagnosed with Scheuermann's kyphosis or adolescent hyperkyphosis.
* Inıtial curve magnitude between 55-75°
* Patients who followed up at least 6 months
* Patients who wearing CAD-CAM (Computer-Aided Design\&Computer-Aided Manufacturing) design TLSO(Thoraco-lumbo-sacral orthosis) kyphosis brace in 16 hours/day or more

Exclusion Criteria:

* History of spinal surgery or trauma
* Patients has kyphosis due to congenital, neuromuscular, traumatic, tumor, infection causes
* Ankylosing spondylitis and other spondyloarthropathies.
* The lack of appropriate full-length lateral radiography with acceptable quality at the baseline or final assessment.

Primary outcomes:
measure: Change from kyphosis angle at 6 months
timeFrame: 6 months after from beginning of study
measure: Change from lordosis angle at 6 months
timeFrame: 6 months after from beginning of study
measure: Change from the global tilt at 6 months
timeFrame: 6 months after from beginning of study
measure: Change from Global Alignment and Proportion (GAP) score at 6 months
timeFrame: 6 months after from beginning
Secondary outcomes:
Other outcomes:
Locations:
city: Istanbul
country: Turkey
facility: Formed Healthcare Scoliosis Treatment and Brace Center
state: İ̇stanbul
Study officials:
affiliation: Medipol University
name: Ahsen Büyükaslan, PhD(c)
role: PRINCIPAL_INVESTIGATOR
affiliation: Başakşehir Çam & Sakura City Hospital
name: Kadir Abul, M.D.
role: STUDY_CHAIR
affiliation: Halic University
name: Hürriyet Yılmaz, Prof.Dr.
role: STUDY_DIRECTOR
References:
Clinical trial NCT02406456: Optimisation of Functional MRI-based Neurofeedback for Alcohol Use Disorders
Official title: Real-time fMRI Neurofeedback as a Treatment Tool for Alcohol Dependence - Protocol Optimisation Phase
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Alcohol Abuse
Lead sponsor: Cardiff University
Sponsor class: OTHER
Collaborators: name: European Commission
First posted: 2015-04-02
Enrollment: 15
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: TREATMENT

Brief summary: Participants will undergo a single session of functional magnetic resonance imaging (fMRI)-based neurofeedback (approximately 1 hour). The investigators will assess their ability to regulate motivational networks of the brain during the exposure to alcohol cues and evaluate immediate effects on craving and cognitive bias for alcohol by administering a questionnaire and a Stroop task before and after the session.


Eligibility criteria: Inclusion Criteria:

* History of alcohol use disorder or current alcohol consumption above 21 units (1 unit = 8g) of alcohol per week (male participants) or above 14 units of alcohol per week (female participants)

Exclusion Criteria:

* MRI safety exclusion criteria

Primary outcomes:
measure: Neurofeedback success (brain activation difference during neurofeedback and baseline blocks)
timeFrame: 1 day
Secondary outcomes:
measure: Drinking Urges Questionnaire as a measure of alcohol craving
timeFrame: 1 day
measure: Alcohol Stroop task as a measure of cognitive bias
timeFrame: 1 day
Other outcomes:
Locations:
city: Cardiff
country: United Kingdom
facility: School of Medicine, Cardiff University
state: Wales
Study officials:
affiliation: Cardiff University
name: David Linden, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT00540956: Natural Killer Cells in Older Patients With Acute Myeloid Leukemia
Official title: Descriptive Study Evaluating the Presence and Function of Natural Killer Cells in Elderly Patients With Acute Myeloid Leukemia in First Remission.
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Leukemia
Keywords: untreated adult acute myeloid leukemia
adult acute megakaryoblastic leukemia (M7)
adult acute minimally differentiated myeloid leukemia (M0)
adult acute monoblastic leukemia (M5a)
adult acute monocytic leukemia (M5b)
adult acute myeloblastic leukemia with maturation (M2)
adult acute myeloblastic leukemia without maturation (M1)
adult acute myelomonocytic leukemia (M4)
adult erythroleukemia (M6a)
adult pure erythroid leukemia (M6b)
adult acute myeloid leukemia with 11q23 (MLL) abnormalities
adult acute myeloid leukemia with inv(16)(p13;q22)
adult acute myeloid leukemia with t(16;16)(p13;q22)
adult acute myeloid leukemia with t(8;21)(q22;q22)
Lead sponsor: National Cancer Institute (NCI)
Sponsor class: NIH
First posted: 2007-10-08
Enrollment: 40
Sex: ALL
Minimum age (years): 65
Standard ages: OLDER_ADULT
Accepts healthy volunteers: no
Primary purpose: TREATMENT

Brief summary: RATIONALE: Studying natural killer cells in samples of blood from patients with cancer may help doctors find out how these cells are effected by chemotherapy.

PURPOSE: This clinical trial is studying natural killer cells in older patients with acute myeloid leukemia.

Detailed description: OBJECTIVES:

Primary

* Determine the evolution of functional receptors of natural killer (NK) cells after completion of chemotherapy in elderly patients with acute myeloid leukemia in first remission.

Secondary

* Measure the kinetics of cytotoxic functional recovery of NK cells.
* Determine activation markers of NK cells.

OUTLINE: This is a multicenter study.

Patients receive 1 course of consolidation therapy comprising an anthracycline and cytarabine to induce first remission.

Blood is collected on day 0 of the consolidation course and then every 2 weeks for 8 weeks.

Eligibility criteria: DISEASE CHARACTERISTICS:

* Diagnosis of acute myeloid leukemia

  * No promyelocytic leukemia
  * No prior therapy

PATIENT CHARACTERISTICS:

* Hemoglobin \> 10 g/dL

PRIOR CONCURRENT THERAPY:

* See Disease Characteristics

Primary outcomes:
measure: Evolution of functional natural killer (NK) cells after chemotherapy
Secondary outcomes:
measure: Kinetics of NK cells
measure: Activation markers of NK cells
Other outcomes:
Locations:
city: Marseille
country: France
facility: Marseille Institute of Cancer - Institut J. Paoli and I. Calmettes
Study officials:
affiliation: Institut Paoli-Calmettes
name: Norbert Vey, MD
References:
Clinical trial NCT03589209: Prediciton of the Round Window Visibility Through Posterior Tympanotomy by CT Scan Analysis
Official title: Preoperative CT Scan Analysis to Predict Perioperative Round Window Visibility Through the Posterior Tympanotoy in Cochlear Implant Surgery
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Tympanostomy Tube Insertion
Keywords: Round window visibility
Cochlear implantation
Lead sponsor: University Hospital, Strasbourg, France
Sponsor class: OTHER
First posted: 2018-07-17
Enrollment: 100
Sex: ALL
Minimum age (years): 9
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: RETROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Implanted cochlear subject in the ENT department of Strasbourg between 1st January 2010 and 1st March 2018

Brief summary: It is difficult to predict the intraoperative visibility of the round window through the posterior Tympanostomy. In case of non-visualization, the surgeon may have to change operative technique during cochlear implant surgery.

The primary purpose of the study is to define relevant CT measurements on the preoperative scanner to predict the perioperative visibility of the round window. Define relevant CT measurements on the preoperative scanner to predict the perioperative visibility of the round window.

The secondary purpose is to validate the investigator's scanner reading protocol for a prospective study.


Eligibility criteria: Inclusion Criteria:

* Aged subject from 9 months and over
* Implanted cochlear subject in the ENT department of Strasbourg between 1st January 2010 and 1st March 2018
* Subject (or the holders of parental authority in the case of minors) having agreed to the use of medical data for the purpose of this research.

Exclusion Criteria:

* Refusal of the patient to participate in the study
* CROP does not make it possible to evaluate the visibility of the FR
* Preoperative or uninterpretable scanner
* Major anatomical malformation
* Subject under the protection of justice
* Subject under guardianship or curatorship

Primary outcomes:
measure: Measure of the correlation between preoperative CT measurements and the visibility of the round window observed intraoperatively (based on the operative records)
timeFrame: 1 day after cochlear implantation surgery
Secondary outcomes:
Other outcomes:
Locations:
city: Strasbourg
country: France
facility: Service D'Orl Et de Chirurgie Cervico-Faciale
Study officials:
affiliation: University Hospital, Strasbourg, France
name: Anne CHARPIOT, MD, PhD
role: STUDY_DIRECTOR
References:
Clinical trial NCT05404009: Collecting Dietary Information From People Undergoing Cancer Treatment
Official title: Prospective, Digitized Dietary Intake Monitoring in Individuals Undergoing Cancer Therapy
Study type: OBSERVATIONAL
Overall status: ACTIVE_NOT_RECRUITING
Conditions: Receiving Allogeneic Hematopoietic Cell Transplants
Keywords: Dietary Intake Monitoring
22-149
Lead sponsor: Memorial Sloan Kettering Cancer Center
Sponsor class: OTHER
First posted: 2022-06-03
Enrollment: 150
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Several prospective subcohorts of patients will be recruited in a rolling fashion. The first 3 subcohorts will comprise allo-HCT, auto-HCT, and CAR-T recipients.

Brief summary: The purpose of this study is to develop a secure method of collecting dietary and nutritional intake information from people with cancer. The researchers will use this information to learn more about how dietary information may relate to cancer diagnosis and response to treatment, and to identify factors that may lead to higher or lower risk of cancer.


Eligibility criteria: Inclusion Criteria:

* Patient is receiving or planning to receive therapy for cancer.
* Patient (or caregiver) has sufficient English proficiency.

Exclusion Criteria:

* None

Primary outcomes:
measure: establish a prospective database
timeFrame: 2 years
Secondary outcomes:
Other outcomes:
Locations:
city: New York
country: United States
facility: Memorial Sloan Kettering Cancer Center (All Protocol Activities)
state: New York
Study officials:
affiliation: Memorial Sloan Kettering Cancer Center
name: Jonathan Peled, MD, PhD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT02679209: Evaluation of Amnion Chorion Membrane and Demineralized Bone Matrix Putty Allograft in Periodontal Intrabony Defects
Official title: Clinical and Radiographic Evaluation of Amnion Chorion Membrane and Demineralized Bone Matrix Putty Allograft for Management of Periodontal Intrabony Defects: a Randomized Clinical Trial.
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Chronic Periodontitis
Lead sponsor: Cairo University
Sponsor class: OTHER
First posted: 2016-02-10
Enrollment: 22
Sex: ALL
Minimum age (years): 35
Maximum age (years): 50
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: A clinical and radiographic evaluation of 2 regenerative techniques, bioresorbable membrane and bone allograft for management of periodontal intrabony defects.

Detailed description: Twenty-two patients suffering from advanced chronic periodontitis were included in this randomized controlled clinical trial. Each subject contributed had two- or three-walled intrabony defects. Patients were randomly assigned into two groups; bioresorbable membrane or bone allograft. Clinical parameters were recorded at baseline and at 3 and 6 months postoperatively. Radiographic parameters were recorded at baseline and at 6 months postoperatively.

Eligibility criteria: Inclusion Criteria:

* Severe chronic periodontitis patients.
* having at least one site with pocket depth ≥ 6 mm and clinical attachment level ≥ 5 mm, with radiographic evidence of bone loss as detected in periapical radiographs.

Exclusion Criteria:

* Pregnant women
* Having any given systemic disease
* Taking any type of medication and/or antibiotic therapy during the 3 months before the study
* Received periodontal treatment within the past 12 months Current or former smokers

Primary outcomes:
measure: Clinical attachment level
timeFrame: change from Baseline at 6 months
Secondary outcomes:
measure: pocket depth
timeFrame: Baseline and 6 months
measure: bone defect area
timeFrame: Baseline and 6 months
Other outcomes:
Locations:
city: Cairo
country: Egypt
facility: Faculty of Oral and Dental Medicine, Cairo University
Study officials:
affiliation: Associate Professor of Oral and Maxillofacial Radiology
name: Riham Hamdy, pHD
role: STUDY_CHAIR
affiliation: Master student at Oral medicine and Periodontology department
name: Amr Temraz, BDs
role: PRINCIPAL_INVESTIGATOR
affiliation: Professor of Oral Medicine & Periodontology, Cairo Unv.
name: Omnia Abouldahab, phD
role: STUDY_DIRECTOR
References:
citation: Kothiwale SV, Anuroopa P, Gajiwala AL. A clinical and radiological evaluation of DFDBA with amniotic membrane versus bovine derived xenograft with amniotic membrane in human periodontal grade II furcation defects. Cell Tissue Bank. 2009 Nov;10(4):317-26. doi: 10.1007/s10561-009-9126-3. Epub 2009 Mar 10.
Clinical trial NCT01855009: Study of Parental Ratings of Quality of Life and Body Composition in 5-19 Year Olds While Participating in the Good NEWS 4 Kids Program
Official title: A Comparative Effectiveness Research Study Comparing Changes in Body Composition and Parent Ratings of Quality of Life in 5-19 Year Olds as a Function of Participation in One of Four Versions of the Good NEWS 4 Kids Program (GN4K)
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Quality of Life
Body Mass Index
Keywords: Quality of Life
Body Weight and Measures
Malnutrition
Adolescent Nutrition Sciences
Sleep Initiation and Maintenance Disorder
Motor Activity
Drinking
Lead sponsor: Integrative Health Technologies, Inc.
Sponsor class: NETWORK
Collaborators: name: MannaRelief Ministries
First posted: 2013-05-16
Enrollment: 200
Sex: ALL
Minimum age (years): 5
Maximum age (years): 19
Standard ages: CHILD
ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL

Brief summary: This study will compare changes in body composition (lean mass, fat, and bone)and parent ratings of quality of life in 5-19 Year Olds as a function of participation in one of four versions of the Good NEWS 4 Kids Program (GN4K).

Detailed description: Purpose: The objectives of this study are to:

1. Compare the relative efficacy of four variations of the GN4K program in facilitating positive changes in body composition and parental ratings of quality of life.
2. Compare parental ratings of children's behavior to DXA-measured changes in body composition;
3. Compare measurements of scale weight, height, waist/hip ratios and BMI with DXA-measured changes in body composition;
4. Develop a logarithm formula with the use of anthropometric measurements and parental ratings to predict body composition changes

Eligibility criteria: Inclusion Criteria:

* Must ensure with medical provider that there are not medical conditions that would preclude participation
* Must be between the ages of 5 and 19

Exclusion Criteria:

* males and females below the age of 5 and above the age of 19
* pregnant or breast feeding

Primary outcomes:
measure: Change from baseline in parental ratings of participating child's quality of life
timeFrame: 0 and 90 days
Secondary outcomes:
measure: Changes in body composition as a measurement of Dual Energy Absorptiometry
timeFrame: 0 and 90 days
measure: Changes in hip to waist ratios
timeFrame: 0 and 90 days
measure: Changes in blood pressure
timeFrame: 0 and 90 days
measure: Changes in gender and age adjusted BMI
timeFrame: 0 and 90 days
Other outcomes:
Locations:
city: San Antonio
country: United States
facility: Integrative Health Technologies
state: Texas
Study officials:
affiliation: Integrative Health Technologies, Inc.
name: Gilbert R Kaats, PhD FACN
role: PRINCIPAL_INVESTIGATOR
affiliation: Georgetown University Medical Center, Dept of Biochemistry, Medicine and Pathology
name: Harry G Preuss, MD MACN
role: STUDY_CHAIR
References:
Clinical trial NCT00230009: Brief Intervention in At-Risk First-time Mothers
Official title: Brief Intervention in At-Risk First-time Mothers
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE1
PHASE2
Conditions: Substance Use
Keywords: child abuse, child neglect, substance use, violence exposure, brief intervention
Lead sponsor: Wayne State University
Sponsor class: OTHER
Collaborators: name: National Institute on Drug Abuse (NIDA)
First posted: 2005-09-30
Enrollment: 100
Sex: FEMALE
Minimum age (years): 18
Maximum age (years): 45
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: PREVENTION

Brief summary: Preliminary controlled trial of a brief intervention designed to reduce child maltreatment risk among low-income pregnant mothers. Foci will include major risk factors for maltreatment, including substance abuse, social isolation, depression, violence exposure, and maladaptive child-rearing attitudes/beliefs.


Eligibility criteria: Pregnant, expecting first child

Inclusion Criteria:

Receipt of public assistance (e.g., Medicaid, Food Stamps), ability to communicate in English

Exclusion Criteria:

Frank psychosis or other cognitive impairment

Primary outcomes:
measure: Alcohol Use
timeFrame: 3 month follow-up
measure: Drug Use
timeFrame: 3 month follow-up
measure: Child Abuse Potential
timeFrame: baseline and 3 month follow-up
measure: Treatment Engagement
timeFrame: at 3 month follow-up
Secondary outcomes:
measure: Depression
timeFrame: at 3 month follow-up
Other outcomes:
Locations:
city: Detroit
country: United States
facility: Wayne State University
state: Michigan
Study officials:
affiliation: Wayne State University
name: Steven J Ondersma, Ph.D.
role: PRINCIPAL_INVESTIGATOR
References:
citation: Delaney-Black V, Covington C, Ondersma SJ, Nordstrom-Klee B, Templin T, Ager J, Janisse J, Sokol RJ. Violence exposure, trauma, and IQ and/or reading deficits among urban children. Arch Pediatr Adolesc Med. 2002 Mar;156(3):280-5. doi: 10.1001/archpedi.156.3.280.
citation: Ondersma SJ, Chaffin MJ, Mullins SM, LeBreton JM. A brief form of the child abuse potential inventory: development and validation. J Clin Child Adolesc Psychol. 2005 Jun;34(2):301-11. doi: 10.1207/s15374424jccp3402_9.
citation: Mullins SM, Bard DE, Ondersma SJ. Comprehensive services for mothers of drug-exposed infants: relations between program participation and subsequent child protective services reports. Child Maltreat. 2005 Feb;10(1):72-81. doi: 10.1177/1077559504272101.
citation: Mullins SM, Suarez M, Ondersma SJ, Page MC. The impact of motivational interviewing on substance abuse treatment retention: a randomized control trial of women involved with child welfare. J Subst Abuse Treat. 2004 Jul;27(1):51-8. doi: 10.1016/j.jsat.2004.03.010.
Clinical trial NCT02450409: A New Technique to Produce Anatomical Alignment Results With Less Midflexion Instability in Total Knee Arthroplasty
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Osteoarthritis, Knee
Keywords: Total knee arthroplasty
Midflexion instability
Gap technique
Anatomical alignment
Lead sponsor: University of Jena
Sponsor class: OTHER
First posted: 2015-05-21
Enrollment: 56
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: Beside the current standard of classical mechanical alignment of total knee replacements, increased interest is being shown in anatomical alignment. However, no surgical technique is capable of controlling the stability of the joint in midflexion. The purpose of the present study was to present and evaluate a new surgical technique, which aims to reduce the need for soft-tissue release and optimize stability in midflexion.


Eligibility criteria: Inclusion Criteria:

* The patients were to undergo surface replacement due to primary osteoarthritis of the knee

Exclusion Criteria:

* Joints that had undergone open surgery beforehand (e.g. high tibial osteotomy, fracture treatment) were excluded.

Primary outcomes:
measure: Measurement of midflexion instability (i.e. tibofemoral gap medially and laterally) in 30° and 60° of flexion
timeFrame: intraoperatively immediately before implantation of definite implants.
Secondary outcomes:
measure: performance of soft tissue release (yes / no) and extend of release if done.
timeFrame: intraoperatively
Other outcomes:
measure: The Knee Society Score
timeFrame: 1 year postoperatively
Locations:
city: Eisenberg
country: Germany
facility: Friedrich-Schiller University Jena, Campus Eisenberg
Study officials:
References: