Clinical trial NCT06764485: A Study to Compare the Efficacy and Safety of BMS-986365 Versus the Investigator's Choice of Therapy in Participants With Metastatic Castration-resistant Prostate Cancer
Official title: A Phase 3, Two-part, Randomized, Open-label, Adaptive Study Comparing BMS-986365 Versus Investigator's Choice of Therapy Comprising Either Docetaxel or Second Androgen Receptor Pathway Inhibitor (ARPI), in Participants With Metastatic Castration-resistant Prostate Cancer (mCRPC) - rechARge
Study type: INTERVENTIONAL
Overall status: RECRUITING
Phase: PHASE3
Conditions: Metastatic Castration-resistant Prostate Cancer
Keywords: Prostate cancer
Protein degrader
Protein degradation
Androgen receptor
Castrate resistant prostate cancer
Castration resistant prostate cancer
Hormone resistant
Metastatic hormone resistant prostate cancer
Metastatic castrate resistant prostate cancer
Metastatic castration resistant prostate cancer
BMS-986365
CC-94676
CA071-1000
CA0711000
rechARge
Abiraterone
Docetaxel
Enzalutamide
Lead sponsor: Celgene
Sponsor class: INDUSTRY
First posted: 2025-01-08
Enrollment: 960
Sex: MALE
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The purpose of this study is to compare the efficacy and safety of BMS-986365 versus the investigator's choice of therapy in participants with Metastatic Castration-resistant Prostate Cancer.

Detailed description: The primary objective of this clinical trial is to assess the radiographic progression free survival (rPFS) of BMS-986365 versus investigator's choice comprising Docetaxel + Prednisone/Prednisolone or Abiraterone + Prednisone/Prednisolone or Enzalutamide.

In Part 1, participants will be randomized 1:1:1 to one of the two BMS-986365 dose levels, or to the active comparator arm (investigator's choice). In Part 2 of the study, participants will be randomized 1:1 between BMS-986365 selected dose, or to the active comparator arm (investigator's choice).

Eligibility criteria: Inclusion Criteria

* Participants must have histologic or cytologic confirmation of adenocarcinoma of the prostate without small cell or neuro-endocrine features.
* Participants must have current evidence of metastatic disease documented by either bone lesions on radionuclide bone scan and/or soft tissue lesions on computed tomography/magnetic resonance imaging (CT/MRI).
* Participants must be asymptomatic or mildly symptomatic from prostate cancer with score on Brief Pain Inventory - Short Form (BPI-SF) that must be \< 4.
* Participants must have had previous treatment with an androgen receptor pathway inhibitor (abiraterone, enzalutamide, apalutamide, or darolutamide).

Exclusion Criteria

* Participants must not have impaired cardiac function or clinically significant cardiac disease.
* Participants must not have any brain metastasis.
* Participants must not have any liver metastasis.
* Participants with superscan on technetium-99m (Tc-99m) radionuclide bone scans.
* Other protocol-defined Inclusion/Exclusion criteria apply.

Primary outcomes:
measure: Radiographic progression-free survival (rPFS) by blinded independent central review (BICR) using Response Evaluation Criteria in Solid Tumors (RECIST) 1.1 (soft tissue) and Prostate Cancer Clinical Trials Working Group 3 (PCWG3) (bone) criteria
timeFrame: Up to 4 years
Secondary outcomes:
measure: Overall Survival (OS)
timeFrame: Up to 4 years
measure: Recommended dose of BMS-986365 for Part 2
timeFrame: Up to approximately 1.5 years
measure: Progression-free survival (PFS)
timeFrame: Up to 4 years
measure: Confirmed overall response rate (ORR) by BICR assessment in participants with measurable disease using RECIST 1.1 (soft tissue) and PCWG3 (bone) criteria
timeFrame: Up to 4 years
measure: Time to pain progression (TTPP)
timeFrame: Up to 4 years
measure: Time to symptomatic progression (TTSP)
timeFrame: Up to 4 years
measure: Time to initiation of the first subsequent systemic therapy (TFST)
timeFrame: Up to 4 years
measure: Prostate-specific antigen (PSA) response rate
timeFrame: Up to 4 years
measure: Change from baseline in Functional Assessment of Cancer Therapy - Prostate Cancer (FACT-P) total scores
timeFrame: Up to 4 years
measure: Change from baseline in Prostate Cancer Subscale (PCS) scores
timeFrame: Up to 4 years
measure: Change from baseline in trial outcome index (TOI)
timeFrame: Up to 4 years
measure: Change from baseline in Brief Pain Inventory - Short Form (BPI-SF) worst pain (item #3) intensity
timeFrame: Up to 4 years
measure: Incidence of adverse events (AEs)
timeFrame: Up to 4 years
measure: Incidence of serious adverse events (SAEs)
timeFrame: Up to 4 years
measure: Incidence of AEs leading to dose modifications
timeFrame: Up to 4 years
measure: Incidence of AEs leading to interruptions
timeFrame: Up to 4 years
measure: Incidence of AEs leading to discontinuation
timeFrame: Up to 4 years
measure: Electrocardiogram (ECG) findings
timeFrame: Up to 4 years
measure: Incidence of laboratory abnormalities
timeFrame: Up to 4 years
Other outcomes:
Locations:
city: Birmingham
country: United States
facility: Local Institution - 0330
state: Alabama
city: Gilbert
country: United States
facility: Local Institution - 0329
state: Arizona
city: Anaheim
country: United States
facility: Los Angeles Cancer Network (LACN)
state: California
city: La Jolla
country: United States
facility: Moores Cancer Center
state: California
city: Los Alamitos
country: United States
facility: Local Institution - 0224
state: California
city: Los Angeles
country: United States
facility: Local Institution - 0364
state: California
city: San Francisco
country: United States
facility: Local Institution - 0016
state: California
city: San Francisco
country: United States
facility: Local Institution - 0411
state: California
city: Aurora
country: United States
facility: Local Institution - 0238
state: Colorado
city: Denver
country: United States
facility: Rocky Mountain Cancer Centers, LLP
state: Colorado
city: Washington
country: United States
facility: Local Institution - 0413
state: District of Columbia
city: Athens
country: United States
facility: Local Institution - 0077
state: Georgia
city: Chicago
country: United States
facility: Local Institution - 0048
state: Illinois
city: Westwood
country: United States
facility: The University of Kansas Cancer Center - Westwood
state: Kansas
city: Wichita
country: United States
facility: Local Institution - 0060
state: Kansas
city: Baltimore
country: United States
facility: Local Institution - 0019
state: Maryland
city: Frederick
country: United States
facility: Local Institution - 0344
state: Maryland
city: Towson
country: United States
facility: Local Institution - 0054
state: Maryland
city: Minneapolis
country: United States
facility: Local Institution - 0104
state: Minnesota
city: Las Vegas
country: United States
facility: Local Institution - 0049
state: Nevada
city: Albuquerque
country: United States
facility: University of New Mexico Comprehensive Cancer Center
state: New Mexico
city: Albuquerque
country: United States
facility: New Mexico Oncology Hematology Consultants Ltd.
state: New Mexico
city: Buffalo
country: United States
facility: Local Institution - 0197
state: New York
city: Mineola
country: United States
facility: Perlmutter Cancer Center at NYU Langone Hospital - Long Island
state: New York
city: New York
country: United States
facility: Laura and Isaac Perlmutter Cancer Center
state: New York
city: New York
country: United States
facility: Local Institution - 0076
state: New York
city: New York
country: United States
facility: Local Institution - 0085
state: New York
city: New York
country: United States
facility: Local Institution - 0071
state: New York
city: Syracuse
country: United States
facility: Local Institution - 0225
state: New York
city: Columbus
country: United States
facility: Local Institution - 0056
state: Ohio
city: Portland
country: United States
facility: Local Institution - 0067
state: Oregon
city: Portland
country: United States
facility: Local Institution - 0416
state: Oregon
city: Philadelphia
country: United States
facility: Local Institution - 0345
state: Pennsylvania
city: Philadelphia
country: United States
facility: Local Institution - 0414
state: Pennsylvania
city: Philadelphia
country: United States
facility: Fox Chase Cancer Center
state: Pennsylvania
city: Willow Grove
country: United States
facility: Local Institution - 0349
state: Pennsylvania
city: Charleston
country: United States
facility: Local Institution - 0055
state: South Carolina
city: Myrtle Beach
country: United States
facility: Carolina Urologic Research Center, LLC
state: South Carolina
city: Nashville
country: United States
facility: Tennessee Oncology
state: Tennessee
city: Austin
country: United States
facility: Local Institution - 0114
state: Texas
city: Austin
country: United States
facility: Texas Oncology - Central/South Texas
state: Texas
city: Houston
country: United States
facility: Local Institution - 0220
state: Texas
city: Houston
country: United States
facility: University of Texas MD Anderson Cancer Center
state: Texas
city: Murray
country: United States
facility: Local Institution - 0109
state: Utah
city: Charlottesville
country: United States
facility: University of Virginia Cancer Center
state: Virginia
city: Richmond
country: United States
facility: Local Institution - 0023
state: Virginia
city: Seattle
country: United States
facility: Local Institution - 0078
state: Washington
city: Vancouver
country: United States
facility: Northwest Cancer Specialists, P.C.
state: Washington
city: Milwaukee
country: United States
facility: Local Institution - 0112
state: Wisconsin
city: Caba
country: Argentina
facility: Hospital Británico de Buenos Aires
state: Buenos Aires
city: Ciudad Autónoma de Buenos Aires
country: Argentina
facility: Local Institution - 0124
state: Buenos Aires
city: ABB
country: Argentina
facility: Local Institution - 0128
state: Ciudad Autónoma De Buenos Aires
city: Río Cuarto
country: Argentina
facility: Local Institution - 0130
state: Córdoba
city: Viedma
country: Argentina
facility: Local Institution - 0136
state: R
city: Buenos Aires
country: Argentina
facility: Asociación de Beneficencia Hospital Sirio Libanés
city: Cordoba
country: Argentina
facility: Hospital Italiano de Córdoba
city: Campbelltown
country: Australia
facility: GenesisCare - Campbelltown
state: New South Wales
city: Darlinghurst
country: Australia
facility: Local Institution - 0359
state: New South Wales
city: Macquarie University
country: Australia
facility: Macquarie University
state: New South Wales
city: Port Macquarie
country: Australia
facility: Port Macquarie - Mid North Coast Cancer Institute
state: New South Wales
city: Wahroonga
country: Australia
facility: Sydney Adventist Hospital
state: New South Wales
city: Greenslopes
country: Australia
facility: Greenslopes Private Hospital - Gallipoli Medical Research Foundation
state: Queensland
city: Southport
country: Australia
facility: Tasman Oncology Research
state: Queensland
city: Adelaide
country: Australia
facility: Local Institution - 0362
state: South Australia
city: Elizabeth Vale
country: Australia
facility: Lyell McEwin Hospital
state: South Australia
city: Kurralta Park
country: Australia
facility: ICON Cancer Centre - Kurralta Park
state: South Australia
city: Hobart
country: Australia
facility: Icon Cancer Centre Hobart
state: Tasmania
city: Heidelberg
country: Australia
facility: Local Institution - 0363
state: Victoria
city: Malvern
country: Australia
facility: Cabrini Hospital - Malvern
state: Victoria
city: Melbourne
country: Australia
facility: Peter MacCallum Cancer Centre
state: Victoria
city: Melbourne
country: Australia
facility: The Alfred Hospital
state: Victoria
city: Murdoch
country: Australia
facility: St. John of God Murdoch Hospital
state: Western Australia
city: Krems
country: Austria
facility: Local Institution - 0369
state: Niederösterreich
city: Linz
country: Austria
facility: Ordensklinikum Linz GmbH Elisabethinen
state: Oberösterreich
city: Salzburg
country: Austria
facility: Local Institution - 0367
city: Wien
country: Austria
facility: Local Institution - 0368
city: Vitória
country: Brazil
facility: Local Institution - 0039
state: Espírito Santo
city: Belo Horizonte
country: Brazil
facility: Local Institution - 0025
state: Minas Gerais
city: Natal
country: Brazil
facility: Local Institution - 0035
state: Rio Grande Do Norte
city: Porto Alegre
country: Brazil
facility: Local Institution - 0026
state: Rio Grande Do Sul
city: Sao Paulo
country: Brazil
facility: Local Institution - 0395
state: São Paulo
city: Sao Paulo
country: Brazil
facility: Local Institution - 0031
state: São Paulo
city: Kelowna
country: Canada
facility: Local Institution - 0304
state: British Columbia
city: Vancouver
country: Canada
facility: Local Institution - 0152
state: British Columbia
city: Halifax
country: Canada
facility: Local Institution - 0151
state: Nova Scotia
city: Toronto
country: Canada
facility: Local Institution - 0193
state: Ontario
city: Chicoutimi
country: Canada
facility: CIUSSS- saguenay-Lac-Saint-Jean
state: Quebec
city: Montréal
country: Canada
facility: Local Institution - 0305
state: Quebec
city: Quebec City
country: Canada
facility: Centre intégré de cancérologie du CHU de Québec Université Laval, Hôpital de l'Enfant-Jésus
state: Quebec
city: Rimouski
country: Canada
facility: Centre intégré de santé et de services sociaux du Bas Saint-Laurent- Hôpital régional de Rimouski
state: Quebec
city: Santiago
country: Chile
facility: Fundacion Arturo Lopez Perez (FALP)
state: Región Metropolitana De Santiago
city: Santiago
country: Chile
facility: Bradfordhill
state: Región Metropolitana De Santiago
city: Viña del Mar
country: Chile
facility: Local Institution - 0127
state: Valparaíso
city: Hefei
country: China
facility: Local Institution - 0232
state: Anhui
city: Beijing
country: China
facility: Local Institution - 0168
state: Beijing
city: Beijing
country: China
facility: Local Institution - 0192
state: Beijing
city: Beijing
country: China
facility: Local Institution - 0176
state: Beijing
city: Chongqing
country: China
facility: Local Institution - 0237
state: Chongqing
city: Fuzhou
country: China
facility: Local Institution - 0249
state: Fujian
city: Xiamen
country: China
facility: Local Institution - 0213
state: Fujian
city: Guangzhou
country: China
facility: Local Institution - 0226
state: Guangdong
city: Guangzhou
country: China
facility: Local Institution - 0180
state: Guangdong
city: Huizhou
country: China
facility: Local Institution - 0415
state: Guangdong
city: Harbin
country: China
facility: Local Institution - 0222
state: Heilongjiang
city: Zhengzhou
country: China
facility: Local Institution - 0211
state: Henan
city: Zhengzhou
country: China
facility: Local Institution - 0279
state: Henan
city: Wuhan
country: China
facility: Local Institution - 0284
state: Hubei
city: Changsha
country: China
facility: Local Institution - 0216
state: Hunan
city: Changsha
country: China
facility: Local Institution - 0217
state: Hunan
city: Changzhou
country: China
facility: Local Institution - 0417
state: Jiangsu
city: Nanjing
country: China
facility: Local Institution - 0233
state: Jiangsu
city: Nanjing
country: China
facility: Local Institution - 0228
state: Jiangsu
city: Nanjing
country: China
facility: Local Institution - 0229
state: Jiangsu
city: Nanchang
country: China
facility: Local Institution - 0219
state: Jiangxi
city: Xi'an
country: China
facility: Local Institution - 0198
state: Shaanxi
city: Jinan
country: China
facility: Local Institution - 0191
state: Shandong
city: Yantai
country: China
facility: Local Institution - 0221
state: Shandong
city: Shanghai
country: China
facility: Local Institution - 0300
state: Shanghai
city: Shanghai
country: China
facility: Local Institution - 0212
state: Shanghai
city: Shanghai
country: China
facility: Local Institution - 0214
state: Shanghai
city: Shanghai
country: China
facility: Local Institution - 0215
state: Shanghai
city: Shanghai
country: China
facility: Local Institution - 0308
state: Shanghai
city: Taiyuan
country: China
facility: Local Institution - 0205
state: Shanxi
city: Cheng Du
country: China
facility: Local Institution - 0278
state: Sichuan
city: Chengdu
country: China
facility: Local Institution - 0240
state: Sichuan
city: Chengdu
country: China
facility: Local Institution - 0283
state: Sichuan
city: Urumqi
country: China
facility: Local Institution - 0218
state: Xinjiang
city: Hangzhou
country: China
facility: Local Institution - 0181
state: Zhejiang
city: Hangzhou
country: China
facility: Local Institution - 0196
state: Zhejiang
city: Hangzhou
country: China
facility: Local Institution - 0280
state: Zhejiang
city: Linhai
country: China
facility: Local Institution - 0281
state: Zhejiang
city: Wenzhou
country: China
facility: Local Institution - 0223
state: Zhejiang
city: Horovice
country: Czechia
facility: Local Institution - 0011
state: Beroun
city: Brno
country: Czechia
facility: Local Institution - 0008
state: Brno-město
city: Hradec Kralove
country: Czechia
facility: Local Institution - 0005
state: Hradec Králové
city: Olomouc
country: Czechia
facility: Local Institution - 0010
state: Olomoucký Kraj
city: Prague
country: Czechia
facility: Local Institution - 0009
state: Praha 2
city: Praha
country: Czechia
facility: Local Institution - 0004
state: Praha 5
city: Praha 2
country: Czechia
facility: Local Institution - 0006
city: Copenhagen
country: Denmark
facility: Local Institution - 0243
state: Hovedstaden
city: Copenhagen
country: Denmark
facility: Rigshospitalet
state: Hovedstaden
city: Aarhus
country: Denmark
facility: Aarhus Universitetshospital, Skejby
state: Midtjylland
city: Aalborg
country: Denmark
facility: Local Institution - 0100
state: Nordjylland
city: Nice
country: France
facility: Local Institution - 0167
state: Alpes-Maritimes
city: Strasbourg
country: France
facility: Local Institution - 0169
state: Alsace
city: Toulouse
country: France
facility: Local Institution - 0307
state: Haute-Garonne
city: Vandoeuvre-lès-Nancy
country: France
facility: Local Institution - 0177
state: Lorraine
city: Pierre-Bénite
country: France
facility: Local Institution - 0166
state: Rhône
city: Le Mans
country: France
facility: Local Institution - 0231
state: Sarthe
city: Villejuif
country: France
facility: Local Institution - 0179
state: Val-de-Marne
city: Clermont-Ferrand
country: France
facility: Local Institution - 0165
city: Paris
country: France
facility: Local Institution - 0178
city: München
country: Germany
facility: Local Institution - 0374
state: Bayern
city: Lübeck
country: Germany
facility: Local Institution - 0371
state: Schleswig-Holstein
city: Jena
country: Germany
facility: Universitätsklinikum Jena
state: Thüringen
city: Bonn
country: Germany
facility: Local Institution - 0382
city: Essen
country: Germany
facility: Local Institution - 0375
city: Hamburg
country: Germany
facility: Universitaetsklinikum Hamburg-Eppendorf
city: Heidelberg
country: Germany
facility: Local Institution - 0379
city: Herne
country: Germany
facility: Marienhospital Herne
city: Tübingen
country: Germany
facility: Local Institution - 0376
city: Wuerzburg
country: Germany
facility: Universitaetsklinikum Wuerzburg
city: Cork
country: Ireland
facility: Local Institution - 0271
city: Dublin
country: Ireland
facility: Local Institution - 0272
city: Dublin
country: Ireland
facility: Local Institution - 0273
city: Milan
country: Italy
facility: Local Institution - 0157
state: Lombardia
city: Orbassano
country: Italy
facility: Local Institution - 0234
state: Piemonte
city: Rome
country: Italy
facility: Local Institution - 0155
state: Roma
city: Padova
country: Italy
facility: Local Institution - 0153
state: Veneto
city: Arezzo
country: Italy
facility: Local Institution - 0156
city: Foggia
country: Italy
facility: Local Institution - 0409
city: Napoli
country: Italy
facility: Local Institution - 0160
city: Terni
country: Italy
facility: Local Institution - 0159
city: Trento
country: Italy
facility: Local Institution - 0158
city: Goyang-si
country: Korea, Republic of
facility: Local Institution - 0389
state: Kyǒnggi-do
city: Seongnam
country: Korea, Republic of
facility: Local Institution - 0386
state: Kyǒnggi-do
city: Seoul
country: Korea, Republic of
facility: Local Institution - 0385
state: Seoul-teukbyeolsi [Seoul]
city: Seoul
country: Korea, Republic of
facility: Local Institution - 0387
state: Seoul-teukbyeolsi [Seoul]
city: Seoul
country: Korea, Republic of
facility: Local Institution - 0388
state: Seoul-teukbyeolsi [Seoul]
city: Seoul
country: Korea, Republic of
facility: Local Institution - 0384
state: Seoul-teukbyeolsi [Seoul]
city: Wroclaw
country: Poland
facility: Local Institution - 0346
state: Dolnośląskie
city: Warszawa
country: Poland
facility: Local Institution - 0187
state: Mazowieckie
city: Opole
country: Poland
facility: SP ZOZ Opolskie Centrum Onkologii im. prof. Tadeusza Koszarowskiego w Opolu
state: Opolskie
city: Gdansk
country: Poland
facility: COPERNICUS PL, Wojewodzkie Centrum Onkologii
state: Pomorskie
city: Poznań
country: Poland
facility: Local Institution - 0365
state: Wielkopolskie
city: Bydgoszcz
country: Poland
facility: Centrum Onkologii im. Prof. Franciszka Lukaszczyka
city: Katowice
country: Poland
facility: Local Institution - 0336
city: Bytom
country: Poland
facility: Local Institution - 0185
state: Śląskie
city: Mayaguez
country: Puerto Rico
facility: BRCR Global - Mayagüez
city: Craiova
country: Romania
facility: Local Institution - 0139
state: Dolj
city: Ploiești
country: Romania
facility: Local Institution - 0142
state: Prahova
city: Cluj
country: Romania
facility: Local Institution - 0145
city: Cluj
country: Romania
facility: Spitalul Universitar C.F. Cluj-Napoca
city: Iași
country: Romania
facility: Institutul Regional de Oncologie
city: Banska Bystrica
country: Slovakia
facility: Local Institution - 0275
state: Banskobystrický Kraj
city: Prešov
country: Slovakia
facility: Local Institution - 0381
state: Prešovský Kraj
city: Bratislava
country: Slovakia
facility: Local Institution - 0201
city: Martin
country: Slovakia
facility: Local Institution - 0200
state: Žilinský Kraj
city: Cordoba
country: Spain
facility: Hospital Universitario Reina Sofia
state: Andalucía
city: Barcelona
country: Spain
facility: Local Institution - 0310
state: Barcelona [Barcelona]
city: Sabadell
country: Spain
facility: Local Institution - 0311
state: Barcelona [Barcelona]
city: Barakaldo
country: Spain
facility: Local Institution - 0325
state: Bizkaia
city: Santander
country: Spain
facility: Local Institution - 0314
state: Cantabria
city: Barcelona
country: Spain
facility: Local Institution - 0315
state: Catalunya [Cataluña]
city: Lugo
country: Spain
facility: Local Institution - 0319
state: Lugo [Lugo]
city: Madrid
country: Spain
facility: Local Institution - 0321
state: Madrid, Comunidad De
city: Madrid
country: Spain
facility: Local Institution - 0316
state: Madrid, Comunidad De
city: Madrid
country: Spain
facility: Local Institution - 0317
state: Madrid, Comunidad De
city: Madrid
country: Spain
facility: Hospital Universitario La Paz
state: Madrid, Comunidad De
city: Majadahonda
country: Spain
facility: Hospital Universitario Puerta de Hierro Majadahonda
state: Madrid, Comunidad De
city: Pamplona
country: Spain
facility: Local Institution - 0406
state: Navarra
city: Ourense
country: Spain
facility: Local Institution - 0407
state: Ourense [Orense]
city: Badajoz
country: Spain
facility: Local Institution - 0320
city: Burgos
country: Spain
facility: Local Institution - 0328
city: Granada
country: Spain
facility: Local Institution - 0318
city: Madrid
country: Spain
facility: Local Institution - 0309
city: Málaga
country: Spain
facility: Local Institution - 0327
city: Sevilla
country: Spain
facility: Hospital Universitario Virgen Macarena
city: Sevilla
country: Spain
facility: Local Institution - 0313
city: València
country: Spain
facility: Local Institution - 0324
city: Lund
country: Sweden
facility: Local Institution - 0099
state: Skåne Län [se-12]
city: Solna
country: Sweden
facility: Local Institution - 0408
state: Stockholms Län [se-01]
city: Uppsala
country: Sweden
facility: Local Institution - 0097
state: Uppsala Län [se-03]
city: Gothenburg
country: Sweden
facility: Local Institution - 0095
state: Västra Götalands Län [se-14]
city: Taichung
country: Taiwan
facility: China Medical University Hospital
city: Taipei
country: Taiwan
facility: Local Institution - 0399
city: Taipei
country: Taiwan
facility: Local Institution - 0397
city: Taoyuan
country: Taiwan
facility: Local Institution - 0420
city: Adana
country: Turkey
facility: Local Institution - 0340
city: Ankara
country: Turkey
facility: Local Institution - 0339
city: Ankara
country: Turkey
facility: Local Institution - 0341
city: Ankara
country: Turkey
facility: Local Institution - 0338
city: Istanbul
country: Turkey
facility: Local Institution - 0337
city: Istanbul
country: Turkey
facility: Local Institution - 0342
city: Glasgow
country: United Kingdom
facility: Local Institution - 0393
state: Glasgow City
city: Northwood
country: United Kingdom
facility: Local Institution - 0383
state: Hillingdon
city: London
country: United Kingdom
facility: St Bartholomew's Hospital
state: London, City Of
city: London
country: United Kingdom
facility: Royal Marsden Hospital (Sutton)
state: Sutton
city: Manchester
country: United Kingdom
facility: The Christie NHS Foundation Trust
Study officials:
affiliation: Bristol-Myers Squibb
name: Bristol-Myers Squibb
role: STUDY_DIRECTOR
References: