Clinical trial NCT04974437: Metabolic Activation of Brain Areas With Emotional Stimuli Compared With Score in Psychological Test
Official title: Quantitative Assessment of the Activation of Brain Areas With Positive and Negative Emotional Stimuli and Its Correlation With Degrees of Emotional Disorder.
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Emotional Disorder
Keywords: fMRI
Emotion
Cerebral blood volume
Lead sponsor: Instituto del Corazon, Argentina
Sponsor class: OTHER
First posted: 2021-07-23
Enrollment: 16
Sex: ALL
Minimum age (years): 21
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: CASE_CROSSOVER
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: Volunteer participants from the population of the city of La Rioja in Argentina, over 21 years of age.

Brief summary: Quantitative assessment of the activation of brain areas by functional magnetic resonance imaging (fRMI) in the face of positive and negative emotional stimuli using audiovisual materials validated for the local population and its correlation with degrees of emotional disorder based on a score obtained by a validated questionnaire for the local population, in 16 volunteers from the city of La Rioja in Argentina.

Detailed description: The technology applied in fMRI allows us to visualize on a color scale the changes in blood flow in those sectors of the brain that increase their metabolic activity during a given action. This is achieved by mapping the cerebral blood volume, which increases or decreases according to the metabolic activity in a certain region of the brain. This indirect method of measuring the metabolic activity of brain areas is very useful for anatomically identifying motor areas and critical functions in individual patients prior to neurosurgery, to allow better surgical planning. Currently this is its main application in healthcare practice. In the field of research it is applied in clinical neurology, psychiatry and psychology. Studies have been conducted on the activations of brain regions in basic emotions. There is less data on the quantitative differences of these activations in the Argentine population according to the degree of emotional disorder, this being the object of study of this project. Emotional disorders are transversal to different pathologies, with or without a psychotic component.

Eligibility criteria: Inclusion Criteria:

- Must be able to understand the instructions and collaborate during the data adquisition.

Exclusion Criteria:

* Any contraindication to enter an MRI (for example, a pacemaker)
* Claustrophobia.

Primary outcomes:
measure: Differences in fMRI brain activation response in specific brain regions in response to positive and negative emotional stimuli
timeFrame: Cross sectional adquistion of data with fMRI in a 20 minutes session after answering a questionnaire.
Secondary outcomes:
Other outcomes:
Locations:
city: La Rioja
country: Argentina
facility: Incor
Study officials:
affiliation: InCor Heart Institute
name: Ruben F Novoa, MD
role: PRINCIPAL_INVESTIGATOR
References:
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