Clinical trial NCT01805128: Exploration of the Social Cognition in Adolescents With a Dissociative Disorder or Autism Spectrum
Official title: EXPLORATION OF THE SOCIAL COGNITION IN ADOLESCENTS WITH A Dissociative Disorder OR AUTISM SPECTRUM
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Schizophrenia
Autistic Disorder
Keywords: Schizophrenia
Autistic Disorder
social cognition
Lead sponsor: Centre Hospitalier Universitaire de Nice
Sponsor class: OTHER
Collaborators: name: Centre Hospitalier d'Antibes Juans les Pins
name: Centre Hospitalier de Cannes
First posted: 2013-03-06
Enrollment: 60
Sex: ALL
Minimum age (years): 12
Maximum age (years): 18
Standard ages: CHILD
ADULT
Accepts healthy volunteers: yes
Allocation: NON_RANDOMIZED
Intervention model: PARALLEL

Brief summary: The schizophrenic disorders and pervasive developmental disorders are neurodevelopmental disorders distinct origin who share common challenges to engage and maintain social relationships and mutual disturbances of affective contact. An important issue of research is to determine the cognitive and brain mechanisms underlying social disability in these two pathologies. Several lines of social cognition have been systematically explored: the perception of emotions, the ability to attribute intentionality and mental states to others (theory of mind), the understanding of social situations in different contexts. We made the observation today that research findings clearly in the field of autism and schizophrenic disorders that converge on common patterns neurocognitive abnormalities. Consequently, many programs support published today use the same therapeutic targets and the same tools in both pathologies. This raises two questions of science: (1) whether the disorders of social cognition reported in the field of autism and schizophrenia are "specific deficit" and not "specific condition", that is to say they are inherent social disadvantage whatever condition or (2) if these disorders of social cognition is a pattern common to autism and schizophrenia but are the result of specific neurocognitive mechanisms and different in each these pathologies. Systematic exploration of these issues is a current issue for understanding the pathophysiological borders between the two neurodevelopmental disorders but also to better define the potential targets of therapeutic strategies, psycho-educational and remediation of disorders of social cognition in autism and schizophrenia.

Main objective: To compare clinical cognitive profiles in adolescents with a schizophrenic disorder, autistic or healthy in the three areas of social cognition: perception of emotions, attribution of intentions to others (theory of mind) and style attribution. We shall constitute three population groups of patients, a group of patients meeting the diagnosis of schizophrenia, a group of patients with autism and a control group (healthy subjects).

Detailed description: The schizophrenic disorders and pervasive developmental disorders are neurodevelopmental disorders distinct origin who share common challenges to engage and maintain social relationships and mutual disturbances of affective contact. An important issue of research is to determine the cognitive and brain mechanisms underlying social disability in these two pathologies. Several lines of social cognition have been systematically explored: the perception of emotions, the ability to attribute intentionality and mental states to others (theory of mind), the understanding of social situations in different contexts. We made the observation today that research findings clearly in the field of autism and schizophrenic disorders that converge on common patterns neurocognitive abnormalities. Consequently, many programs support published today use the same therapeutic targets and the same tools in both pathologies. This raises two questions of science: (1) whether the disorders of social cognition reported in the field of autism and schizophrenia are "specific deficit" and not "specific condition", that is to say they are inherent social disadvantage whatever condition or (2) if these disorders of social cognition is a pattern common to autism and schizophrenia but are the result of specific neurocognitive mechanisms and different in each these pathologies. Systematic exploration of these issues is a current issue for understanding the pathophysiological borders between the two neurodevelopmental disorders but also to better define the potential targets of therapeutic strategies, psycho-educational and remediation of disorders of social cognition in autism and schizophrenia.

Main objective: To compare clinical cognitive profiles in adolescents with a schizophrenic disorder, autistic or healthy in the three areas of social cognition: perception of emotions, attribution of intentions to others (theory of mind) and style attribution. We shall constitute three population groups of patients, a group of patients meeting the diagnosis of schizophrenia, a group of patients with autism and a control group (healthy subjects).

Inclusion criteria: patients aged 12 to 18, with a verbal IQ greater than or equal to 70, a DSM-IV diagnosis of autism and / or schizophrenia.

Assessment instruments: (1) clinical assessment instruments using standardized structured interviews that have already shown good sensitivity in our preliminary studies (2) techniques neuro-social cognition scientifically validated by the expert group of the ANR we are partners.

The study of active files and preliminary results, we can estimate the population to 20 patients per group, a total of 60 patients.

The originality of this study focuses on the ability to compare two populations in the same field of social cognition in three dimensions, which hitherto have been explored separately in the literature. The expected results are a range of prevention and treatment of major psychiatric children and adolescents because they help define therapeutic targets specific to each population

Eligibility criteria: Inclusion Criteria:

* Child with a DSM-IV diagnosis of schizophrenia or autism spectrum disorder:

  * Schizophrenic patients, positive to the award of psychosis section of the Kiddie SADS and having a negative ADI.

or:

* Patients with autism spectrum disorder, diagnosed by the scale ADI (Autism Diagnostic Interview) or ADOS (Autism Diagnostic Observation Schedule): Autism Asperger and PDD nos. These patients do not respond to a diagnosis of psychosis Kiddie-SADS according.

  * Total IQ greater than or equal to 70

Exclusion Criteria:

* Genetic disorders, neurological and neurosensory
* Child satisfy both the diagnosis of autism spectrum disorder and schizophrenia than (comorbidity).
* Will not be included patients who participate in a study on rehabilitation for social skills.

Primary outcomes:
measure: Compare cognitive profiles in clinical adolescents with a schizophrenic disorder, autistic or healthy in the three areas of social cognition
timeFrame: First day
Secondary outcomes:
measure: Compare the cognitive profiles within the clinical group of schizophrenic
timeFrame: First day
measure: Cognitive profiles compare clinical results between the different types of schizophrenia and autism patients.
timeFrame: First day
Other outcomes:
Locations:
city: Antibes
country: France
facility: Centre Hospitalier d'Antibes Juans les Pins
city: Cannes
country: France
facility: Centre hospitalier de Cannes
city: Nice
country: France
facility: CHU de Nice
Study officials:
affiliation: Centre Hospitalier Universitaire de Nice
name: Emmanuelle DOR, Medical Doctor
role: PRINCIPAL_INVESTIGATOR
References: