Clinical trial NCT06654778: Ultrasound Evaluation of Preventive Measures for Postoperative Lung Atelectasis After Surgery
Official title: Ultrasound Evaluation of Different Preventive Measures of Post Operative Lung Atelectasis After Upper Abdominal Surgeries: Ventilation and Fluid Measures
Study type: INTERVENTIONAL
Overall status: RECRUITING
Phase: NA
Conditions: Pulmonary Atelectasis, Postoperative
Keywords: lung ultrasound
lung Atelectasis
Atelectasis
Pulmonary Atelectasis
pressure controlled ventilation - volume guarantee (PCV- VG)
positive end-expiratory pressure (PEEP)
lung recruitment maneuver
restrictive fluid strategies
Lead sponsor: Al-Azhar University
Sponsor class: OTHER
First posted: 2024-10-23
Enrollment: 60
Sex: ALL
Minimum age (years): 30
Maximum age (years): 60
Standard ages: ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Intervention model description: The patients will be assigned into three equal groups of 20 patients each:

1. Group I: PEEP of 8 cm H2O and fluid management: 500 ml + 4 mL/kg/hour Ringer's lactate
2. Group II: PEEP/RM group, addition of RM (30 cm H2O for 30 s)
3. Group III: PEEP/RM group and restricted fluid management 3 mL/kg/hour Ringer's lactate

A total sample size of 60 patients will be involved.
Primary purpose: PREVENTION

Brief summary: the aim of this prospective randomized blinded clinical study will be to assess the ultrasound evaluation of different preventive measures of post operative lung atelectasis in abdominal surgeries; these measures include ventilation and fluid measures

Detailed description: ultrasound evaluation for application of different preventive measures of post operative lung atelectasis, including positive end-expiratory pressure, lung recruitment maneuvers, and restrictive fluid management.

Eligibility criteria: Inclusion Criteria:

* ASA physical status I or II, of either gender.
* BMI \< 40
* Age 30-60 years
* scheduled for elective abdominal surgeries

Exclusion Criteria:

* Patient refusal
* American Society of Anesthesiologists (ASA) physical status classification system more than II
* BMI \> 40 .
* Psychiatric disorders
* History of chest disorders such as asthma and obstructive pulmonary disease (COPD).
* History of Previous Thoracic Procedures.
* Pregnancy

Primary outcomes:
measure: Lung ultrasound assessment of postoperative pulmonary atelectasis at the end of surgery
timeFrame: at the end of surgery before emergence from GA.
Secondary outcomes:
measure: Lung ultrasound assessment
timeFrame: before induction of general anesthesia
measure: Lung ultrasound assessment
timeFrame: 5 minutes post induction of general anesthesia
measure: Lung ultrasound assessment
timeFrame: 15 minutes after patients arrive to PACU
measure: Lung ultrasound assessment
timeFrame: 60 minutes after patients arrive to PACU
measure: arterial blood gases
timeFrame: 5 minutes post induction of general anesthesia
measure: arterial blood gases
timeFrame: before emergence from general anesthesia
measure: arterial blood gases
timeFrame: 15 minutes after patients arrive to PACU
Other outcomes:
Locations:
city: Assiut
country: Egypt
facility: Al-Azhar university
Study officials:
affiliation: Al-Azhar University
name: Hamed M Wally Allah
role: PRINCIPAL_INVESTIGATOR
References: