Clinical trial NCT01060215: The Effects of Joint Effusion on Proprioception
Official title: Clinical Trial for the Effects of Joint Effusion on Proprioception
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Osteoarthritis
Keywords: effusion
osteoarthritis
knee
Lead sponsor: The Catholic University of Korea
Sponsor class: OTHER
First posted: 2010-02-02
Enrollment: 40
Sex: FEMALE
Minimum age (years): 50
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL

Brief summary: The purpose of this study is to assess the effects of joint effusion on proprioceptive status in patients with knee osteoarthritis (OA).

Detailed description: Proprioception is a sensory modality that provides feedback on the internal status of the body and enables us to perceive joint position and motion.

Osteoarthritis (OA), also called degenerative joint disease, is a major musculoskeletal condition characterized by loss of articular cartilage that leads to pain and loss of function. The most commonly affected joint is the knee, and OA may result in changes that affect not only intracapsular tissues, but also periarticular tissues, such as ligaments, capsules, tendons, and muscles. Many studies have examined the proprioceptive status of knee OA, and subjects with knee OA are known to have impaired proprioception compared with age-matched controls.

Joint effusion is a common symptom associated with chronic degenerative joint condition, but the effects of effusion on knee joint proprioception have not been investigated in detail.

A volume of 20 mL of normal saline was injected into the knee joint cavity of subjects in the experimental group under ultrasonographic guidance. Proprioceptive acuity was assessed by active repositioning of the lower limb using an electrogoniometer to measure knee joint position sense (JPS) under both non-weight-bearing and weight-bearing conditions twice, with a 20-min rest interval.

Eligibility criteria: Inclusion Criteria:

Or at least two of criteria 2-6 established by the American College of Rheumatology (ACR):

1. Kellgren and Lawrence (K/L) grade ≥II
2. morning stiffness \<30 min in duration
3. crepitus on movement of the knee joint
4. bony tenderness at the knee joint margins
5. palpable or visible bony enlargement
6. no palpable warmth.

Exclusion Criteria:

1. the presence of knee joint effusion determined by ultrasonography
2. a history of knee injury or surgery
3. a history of knee injection within 3 months
4. a history of inflammatory arthritis
5. taking anticoagulants
6. balance or gait disturbance
7. diabetes mellitus.

Primary outcomes:
measure: Proprioceptive acuity in Knee Joint. Proprioceptive acuity (difference between the knee angles at the target and reproduced positions) was assessed by active repositioning of the lower limb after injection or no injection.
timeFrame: within one hour after intervention
Secondary outcomes:
Other outcomes:
Locations:
city: Seoul
country: Korea, Republic of
facility: Seoul St. Mary's Hospital
Study officials:
affiliation: Department of Rehabilitation Medicine, Seoul St. Mary's Hospital
name: Jongin Lee, M.D
role: STUDY_CHAIR
References:
citation: Cho YR, Hong BY, Lim SH, Kim HW, Ko YJ, Im SA, Lee JI. Effects of joint effusion on proprioception in patients with knee osteoarthritis: a single-blind, randomized controlled clinical trial. Osteoarthritis Cartilage. 2011 Jan;19(1):22-8. doi: 10.1016/j.joca.2010.10.013. Epub 2010 Oct 27.