Clinical trial NCT04572594: Molecular Profiling and Molecular Labeling of Inflammatory Myofibroblastic Tumor
Official title: Study on the Molecular Profile and Molecular Signature of Inflammatory Myofibroblastic Tumor
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Inflammatory Myofibroblatic Tumor
Keywords: IMT
gene
molecular profiling and molecular markers
Lead sponsor: Sun Yat-sen University
Sponsor class: OTHER
First posted: 2020-10-01
Enrollment: 29
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Observational model: CASE_ONLY
Time perspective: RETROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: From December 2009 to July 2019, the histopathological diagnosis of inflammatory myofibroblastic tumor was confirmed by surgery or puncture at Sun Yat-sen University Cancer Center.

Brief summary: Gene mutation is a research hotspot in the occurrence of multiple malignant tumors. The somatic gene mutations of many different types of tumors not only help to study the tumorigenesis mechanism and molecular diagnosis, but also can be used as an ideal therapeutic target. Large-scale gene profiling studies performed by humans in various types of epithelial tumors have confirmed some new gene mutations. However, there are few reports on the detection of genes related to inflammatory myofibroblastic tumor, and humans have not yet understood its molecular content. Therefore, it is necessary to further use molecular detection methods to explore the molecular markers of IMT to facilitate its follow-up precise treatment plan.

Detailed description: Inflammatory myofibroblastic tumor（IMT）is a rare clinical mesenchymal tissue-derived tumor, which can occur in almost all organs and soft tissues, and is characterized by low-grade or borderline tumors.

The diagnosis of inflammatory myofibroblastic tumor is mainly based on histopathology and immunohistochemistry. The treatment is resistant to conventional chemotherapy and radiotherapy. The only curative treatment is complete surgical resection. When IMT shows typical cellular structural features in pathology, the diagnosis is relatively simple. However, in the presence of atypical features, the accurate diagnosis of IMT is still a challenge. Therefore, it is necessary to explore a better diagnostic method. Secondly, there is no individualized treatment method for aggressive IMT patients who relapse and metastasize after surgery. At present, gene mutation is a research hotspot in the occurrence of various malignant tumors. The somatic gene mutations of many different types of tumors not only help to study the tumorigenesis mechanism and molecular diagnosis, but also can be used as an ideal therapeutic target. Large-scale gene profiling studies performed by humans in various types of epithelial tumors have confirmed some new gene mutations. However, there are few reports on the detection of inflammatory myofibroblastic tumor, and humans have not yet understood its molecular content. Therefore, it is necessary to further use molecular detection methods to explore the molecular markers of IMT to facilitate its follow-up precise treatment plan.

Eligibility criteria: Inclusion Criteria:

1. From December 2009 to July 2019, patients who were pathologically diagnosed with inflammatory myofibroblastic tumor by Sun Yat-sen University Cancer Center；
2. There are related pathological tissue wax blocks in Sun Yat-sen University Cancer Center;
3. Patient clinical and prognosis tracking data are available.

Exclusion Criteria:

The patient who has a clinically detectable second primary malignant tumor.

Primary outcomes:
measure: Establishing gene mutation spectrum of patients with inflammatory myofibroblastic tumor
timeFrame: through study completion，an average of 1 year
Secondary outcomes:
measure: Exploring molecular markers for inflammatory myofibroblastic tumor
timeFrame: through study completion，an average of 1 year
Other outcomes:
Locations:
city: Guangzhou
country: China
facility: Cancer center of SunYat-sen University
state: Guangdong
Study officials:
affiliation: Sun Yat-sen University
name: Dongsheng Zhang, PhD
role: PRINCIPAL_INVESTIGATOR
References: