louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT02748980: Clinical Observation of Coronary Arterial Microcirculation Dysfunction in Diabetic Patients With Non- Obstructive Coronary Artery Disease
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Complications of Diabetes Mellitus
Coronary Artery Disease
Lead sponsor: Shaanxi Provincial People's Hospital
Sponsor class: OTHER
First posted: 2016-04-22
Enrollment: 200
Sex: ALL
Minimum age (years): 18
Maximum age (years): 80
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Hospitalized patients

Brief summary: The purpose of this study is to investigate the prevalence and degree of coronary arterial microcirculaiton dysfunction of non- obstructive coronary artery disease in patients with type 2 diabetes. Furthermore, the risk factors of coronary arterial microcirulation would be screened and identified.


Eligibility criteria: Inclusion Criteria:

* Diagnosis non- obstructive coronary artery disease;
* Positive Treadmill exercise test;
* Positive Cardiac ECT test;
* Positive Holter test

Exclusion Criteria:

* Diagnosis of myocardial infarction;
* Diagnosis heart failure;
* Diagnosis of chronic kidney disease;
* Diagnosis of heart valvular disease;
* Diagnosis of malignant tumor;
* Positive heart transplant history;
* Pregnant and lactating women

Primary outcomes:
measure: The coronary microcirculation dysfunction is measured by index of microcirculatory resistance
timeFrame: 10 minutes after diagnosis is made by CAG
Secondary outcomes:
Other outcomes:
Locations:
city: Xi'an
country: China
facility: Shaanxi Provincial People's Hospital
state: Shaanxi
Study officials:
References:
Clinical trial NCT06901180: in Our Study we Compare Results of Two Oncoplastic Breast Surgery (Short Scar Reduction Mammoplasty and Wise Pattern Reduction Mammoplasty) as Surgical Treatment of Breast Cancer
Official title: Evaluation of Short Scar Periareolar Inferior Pedicle Reduction Mammoplasty in Oncoplastic Breast Surgery
Study type: OBSERVATIONAL
Overall status: NOT_YET_RECRUITING
Conditions: Evaluation of Short Scar Periareolar Inferior Pedicle Reduction Mammoplasty in Oncoplastic Breast Surgery
Lead sponsor: Sohag University
Sponsor class: OTHER
First posted: 2025-03-28
Enrollment: 60
Sex: FEMALE
Minimum age (years): 25
Maximum age (years): 75
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: CASE_CONTROL
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: female patients aged from 25 years to 75 years with early breast cancer that meet inclusion and exclusion criteria

Brief summary: in our study we compare results of two oncoplastic breast surgery (short scar reduction mammoplasty and wise pattern reduction mammoplasty) as surgical treatment of breast cancer


Eligibility criteria: Inclusion Criteria:

1. Female patients with ages ranging from 25 to 75 years.
2. Patients with operable breast cancer (Stage I, II and IIIa).
3. Patients with moderate to large /ptotic breasts.

Exclusion Criteria:

1. Patients with a contraindication to breast conservative surgery:

   1. Multi-centric disease that can't be incorporated by local excision through a single incision that achieves adequate safety margin and satisfactory cosmetic results.
   2. inflammatory carcinoma.
   3. Contraindications to postoperative radiation e.g. pregnancy, pre-existing lung disease with reduced diffusing capacity and pulmonary TB.
   4. diffuse suspicious malignant micro-calcification on mammography.
   5. inability to attain negative surgical margins.
   6. cardiomyopathy
   7. connective tissue disorders with significant vasculitis.
2. Previous chest wall or breast radiation.
3. Patients' refusal participation.

Primary outcomes:
measure: oncological outcomes
timeFrame: 1 year
measure: post operative complications
timeFrame: 1 month
measure: cosmetic outcomes
timeFrame: 1 year
Secondary outcomes:
Other outcomes:
Locations:
city: Sohag
country: Egypt
facility: Sohag University
Study officials:
References:
Clinical trial NCT00687180: Mycophenolate vs Azathioprin in Autoimmune Hepatitis
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE4
Conditions: Autoimmune Hepatitis
Keywords: Prednisolone dosage
Lead sponsor: Rigshospitalet, Denmark
Sponsor class: OTHER
First posted: 2008-05-30
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Primary purpose: TREATMENT

Brief summary: A study with 20 de novo patients with autoimmune hepatitis, 10 receiving azathioprin and 10 receiving mycophenolat mofetil.


Eligibility criteria: Inclusion Criteria:

* De novo autoimmune hepatitis
* Consent

Exclusion Criteria:

* age below 18
* pregnancy

Primary outcomes:
Secondary outcomes:
Other outcomes:
Locations:
city: Copenhagen
country: Denmark
facility: Rigshospitalet, Dept. of Hepatology A-2121
Study officials:
References:
Clinical trial NCT04713280: Maxillary Versus Bi-Maxillary Posterior Segments Intrusion Adult Subjects With Skeletal Open Bite
Official title: Maxillary Versus Bi-Maxillary Posterior Segments Intrusion in Treatment of Adult Subjects With Skeletal Open Bite - A Randomized Clinical Trial
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Dental Malocclusion
Keywords: molar intrusion
open bite
mini-screws
Lead sponsor: Cairo University
Sponsor class: OTHER
First posted: 2021-01-19
Enrollment: 20
Sex: ALL
Minimum age (years): 17
Maximum age (years): 25
Standard ages: CHILD
ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: Compare between bi-maxillary (maxillary and mandibular) posterior dento-alveolar intrusion and maxillary posterior dento-alveolar intrusion as regards open bite closure.

Detailed description: Now, maxillary posterior dento-alveolar intrusion has been validated as a conservative treatment modality for treatment of skeletal open bite in adult patients. However, it was proved that mandibular posterior teeth extrusion take place during the treatment which results in reduction in the amount of open. bite closure. Therefore, the aim of our study is to compare in a randomized clinical trial methodology between maxillary posterior dento-alveolar intrusion and combined maxillary and mandibular posterior dento-alveolar intrusion in terms of anterior open bite closure.

Eligibility criteria: Inclusion Criteria:

* Skeletal open bite with a dental open bite ranging from 3-8 mm.
* Adequate incisal show at rest and on smiling
* Full set of posterior teeth from first premolar to second molar (with the exception of one tooth in one quadrant).

Exclusion Criteria:

* Dental open bites without skeletal components
* Previous orthodontic treatment
* Medically compromised patients

Primary outcomes:
measure: Anterior open bite closure
timeFrame: 6 months
Secondary outcomes:
measure: Maxillary posterior teeth intrusion radiographically in millimeters.
timeFrame: 6 months
measure: Mandibular posterior teeth intrusion radiographically in millimeters.
timeFrame: 6 months
measure: Tip and torque of intruded teeth radiographically in degrees.
timeFrame: 6 months
Other outcomes:
Locations:
city: Cairo
country: Egypt
facility: Orthodontic Department, Faculty of Dentistry, Cairo University
Study officials:
affiliation: Assistant lecturer, PhD candidate
name: Heba Akl, MSc.
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT02611180: Dendritic Cells in Patients With Acute or Chronic Skin Graft Versus Host Disease
Official title: Analysis of Dendritic Cells in Patients With Acute or Chronic Skin Graft Versus Host Disease
Study type: OBSERVATIONAL
Overall status: RECRUITING
Conditions: Acute Graft-versus-host Disease
Acute GVHD
Chronic Graft-versus-host Disease
Chronic GVHD
Lead sponsor: Washington University School of Medicine
Sponsor class: OTHER
First posted: 2015-11-20
Enrollment: 50
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: CASE_ONLY
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Patients with current or suspected acute or chronic GVHD of the skin

Brief summary: Dendritic cells (DCs) serve as sentries for the immune system. DCs recognize foreign compounds (antigens) in the body, which they internalize and process. When DCs uptake foreign antigens, they migrate to secondary lymphoid organs, where the processed antigens are presented to T cells.

Various DC subsets with unique cell lineages, surface protein markers, and tissue localization determinants have been identified. For example, Langerhans cells (LCs) and interstitial dendritic cells (intDCs) are DCs found in stratified epithelia, such as the skin. Though both are expressed in the skin, they differ with respect to their origin and surface protein content and can activate distinct types of immune responses. They may also have different specificities for the capture of antigens and presentation to circulating T cells.

To date, it is unknown what role, if any, the different DC populations that reside or repopulate in the skin play in the development and progression of skin graft-versus-host disease (GVHD) following bone marrow transplant.


Eligibility criteria: Inclusion Criteria:

* At least 18 years of age at enrollment
* Willing and able to sign the informed consent
* Current diagnosis/suspected diagnosis of acute skin GVHD OR Current diagnosis/suspected diagnosis of chronic skin GVHD

Exclusion Criteria:

* Known infection with Hepatitis B or C, HTLV, or HIV
* Pregnant females

Primary outcomes:
measure: Dendritic cell characteristics
timeFrame: Up to 2 years
measure: Antigen specific lymphocyte subset characteristics
timeFrame: Up to 2 years
measure: Genes and skin microbiota that correlate with dendritic cell function
timeFrame: Up to 2 years
measure: Potential treatment targets as measured by deep sequencing or microarray analysis
timeFrame: Up to 2 years
Secondary outcomes:
Other outcomes:
Locations:
city: Saint Louis
country: United States
facility: Washington University School of Medicine
state: Missouri
Study officials:
affiliation: Washington University School of Medicine
name: Eynav Klechevsky, Ph.D.
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT00484380: The Scanner in the Coronary Evaluation
Official title: Contribution of the Scanner in the Coronary Evaluation Before Valvular Replacement
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Valvular Disease
Coronary Stenosis
Keywords: Valvular surgery
Diagnostic accuracy of coronary angiography
Coronary stenosis
Coronary revascularisation
Lead sponsor: French Cardiology Society
Sponsor class: OTHER
Collaborators: name: French Federation of Cardiology
First posted: 2007-06-08
Enrollment: 66
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NON_RANDOMIZED
Intervention model: SINGLE_GROUP
Primary purpose: DIAGNOSTIC

Brief summary: Conventional coronary angiography is the recommended procedure in detection of coronary stenosis in patients with heart valve disease referred for surgery.The aim of this prospective study is to assess diagnostic accuracy of multislice spiral computed tomography coronary angiography in patients with heart valve disease referred for surgery.

Detailed description: The diagnostic accuracy of multislice spiral computed tomography coronary angiography in terms of sensitivity, specificity, negative and positive predictive value, the conventional coronary angiography being the gold standard.50 patients scheduled for valve surgery will be screened to conduct an additional multislice spiral computed tomography.

Eligibility criteria: Inclusion Criteria:

* Patients scheduled for valve surgery who need a conventional coronary angiography
* Informed Content
* Patients affiliated to the social security system

Exclusion Criteria:

* Instable condition
* Arrhythmia including atrial fibrillation
* Impaired renal function
* Known contrast allergy
* Patients unable to hold an apnea during 20 seconds
* Pregnancy
* Emergency
* People unable to sign the informed content such as major under supervision

Primary outcomes:
measure: The diagnostic accuracy of coronary scanner (sensitivity, specificity, positive and negative predictive values) in the detection of the coronary stenosis higher than 50%.
timeFrame: a month at the latest after the signature of consent
Secondary outcomes:
measure: The diagnostic accuracy of coronary scanner to detect the patients requiring or not a coronary revascularisation in more of the valvular surgery.
timeFrame: a month at the latest after the signature of consent
Other outcomes:
Locations:
city: Paris
country: France
facility: Pitié Salpêtrière Hospital
Study officials:
affiliation: Pitié-Salpêtrière Hospital
name: Gérard Helft, MD, PHD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT04381780: Treatment of Fibromyalgia With Recovery Factors
Official title: Treatment of Fibromyalgia With a Unique Polypeptide Nutritional Support
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Fibromyalgia
Chronic Fatigue Syndrome
Lead sponsor: Practitioners Alliance Network
Sponsor class: OTHER
First posted: 2020-05-11
Enrollment: 100
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Intervention model description: Open pilot study
Primary purpose: TREATMENT

Brief summary: Treatment of Fibromyalgia and CFS with Recovery Factors

Detailed description: Use of a unique oral porcine peptide nutritional supplement in those meeting ACR 2010(amended) diagnostic criteria for Fibromyalgia or CDC Criteria for CFS

Eligibility criteria: Inclusion Criteria:

* Meet the ACR 2010 Amended Fibromyalgia Diagnostic Criteria or CFS CDC criteria; Score 5 or less on Energy VAS

Exclusion Criteria:

Under 18 Pregnant Other severe complicating conditions

-

Primary outcomes:
measure: Composite VAS
timeFrame: 6 weeks
Secondary outcomes:
measure: FIQ-R
timeFrame: 1 month
Other outcomes:
Locations:
city: Kailua
country: United States
facility: Jacob Teitelbaum MD
state: Hawaii
Study officials:
References:
Clinical trial NCT02001480: Surrogate Markers for Sudden Cardiac Death in Patients With Diabetes Mellitus and End Stage Renal Disease
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Diabetes Mellitus Type 2
End Stage Renal Disease
Lead sponsor: RWTH Aachen University
Sponsor class: OTHER
First posted: 2013-12-05
Enrollment: 60
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: PREVENTION

Brief summary: Aim: Patients with type 2 diabetes mellitus (T2DM) and hemodialysis due to diabetic nephropathy exhibit a high risk for sudden cardiac death (SCD). Preliminary data suggest that beta-blocker treatment may reduce arrhythmias and mortality in this high-risk population. However, no results from large-scale clinical outcome trials with beta-blockers exist in this patient group and a broad, scientifically unapproved use of beta-blocker treatment may not be justified due to potential harmful side-effects such as AV-block or hypotension. In addition, we are lacking identified ECG surrogate parameters for SCD in this high-risk population and on the occurrence of arrhythmias in temporary relationship to hemodialysis sessions.

Therefore, the present study will identify surrogate parameters of SCD in hemodialysis patients with T2DM and in an interventional trial investigate the suppressive effect of beta-blockers on these identified ECG markers.


Eligibility criteria: Inclusion Criteria:

* patients with diabetes mellitus type 2
* chronic hemodialysis at least since 3 months
* aged above 18 years
* written informed consent
* legally competent

Exclusion Criteria:

* intake of bets-blockker within the last four weeks
* pregnancy and breast feeding
* abuse of drugs and alcohol
* missing compliance
* life expectancy \< 6 month

Primary outcomes:
measure: ECG surrogate markers compared to cardiac events
timeFrame: Analysis will be performed after last patient is out
Secondary outcomes:
measure: Continuous glucose monitoring is performed to identify episodes of hypoglycaemia
timeFrame: Analysis will be done after last patient is out
Other outcomes:
Locations:
city: Coburg
country: Germany
facility: regioMed-Kliniken GmbH
state: Bayern
city: Würzburg
country: Germany
facility: University Hospital Würzburg
state: Bayern
city: Aachen
country: Germany
facility: Department of Internal Medicine I University Hospital RWTH Aachen
state: NRW
Study officials:
affiliation: Department of Internal Medicine University Hospital Aachen
name: Nikolaus Marx, Univ.-Prof.
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT04130880: Turkish Montreal Children's Hospital Feeding Scale
Official title: Reliability and Validity of the Turkish Montreal Children's Hospital Feeding Scale
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Feeding Disorders
Lead sponsor: Hacettepe University
Sponsor class: OTHER
First posted: 2019-10-18
Enrollment: 120
Sex: ALL
Minimum age (years): 18
Maximum age (years): 6
Standard ages: CHILD
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: Children with cerebral palsy and Children with typical development

Brief summary: The purpose of this study is to test the reliability and validity of the Turkish Montreal Children's Hospital Feeding Scale.

Detailed description: The purpose of this study is to test the reliability and validity of the Turkish Montreal Children's Hospital Feeding Scale. The internal consistency, test-retest reliability, and criterion validity of Turkish Montreal Children's Hospital Feeding Scale will be investigated. The internal consistency will be assessed using Cronbach's alpha. Intraclass correlation coefficient (ICC) value with 95 % confidence intervals will be calculated for test-retest reliability. The criterion validity of the scale will be determined by assessing the correlation between the Turkish Montreal Children's Hospital Feeding Scale and Behavioral Pediatrics Feeding Assessment Scale.

Eligibility criteria: Inclusion Criteria:

* Children with cerebral palsy
* Children with typical development
* Aged between 18 months- 6 years

Exclusion Criteria:

* Who aged under the age of 18 months and above the age of 6 years.

Primary outcomes:
measure: Montreal Children's Hospital Feeding Scale
timeFrame: 2 months
Secondary outcomes:
measure: Behavioral Pediatrics Feeding Assessment Scale
timeFrame: 2 months
Other outcomes:
Locations:
city: Edirne
country: Turkey
facility: Özgü İnal
Study officials:
affiliation: Trakya University
name: ÖZGÜ İNAL
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT00878280: Copy Number Variations, Inflammatory Cytokines and the Risk of Dementia
Official title: Copy Number Variations, Expression of Inflammatory Cytokines and the Risk of Dementia - A Two-stage Genome-wide Association Study
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Dementia
Lead sponsor: National Taiwan University Hospital
Sponsor class: OTHER
First posted: 2009-04-08
Enrollment: 700
Sex: ALL
Minimum age (years): 50
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: CASE_CONTROL
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: hospital recruited dementia patients and controls

Brief summary: Assess the association of copy number variation (CNV) and inflammatory cytokine with the risk of dementia.

Detailed description: This is a hospital-based case-control study. We plan to assess the association of CNV and inflammatory cytokine with the risk of dementia. Hopefully to find some genetic biomarkers to identify the risk of dementia at an early stage.

Eligibility criteria: Inclusion Criteria:

* hospital recruited dementia patients and controls

Primary outcomes:
measure: Dementia
timeFrame: Aug 2008-July 2011
Secondary outcomes:
Other outcomes:
Locations:
city: Taipei
country: Taiwan
facility: National Taiwan University Hospital
Study officials:
affiliation: National Taiwan University Hospital
name: yen-ching chen, ScD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT01988480: Guided Surgery Versus Sinus Graft
Official title: Clinical Assessment of Innovative Procedure Using Image-guided Surgery to Avoid Sinus Lift
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Edentulous
Keywords: Guided surgery
Sinus graft
Lead sponsor: Hospices Civils de Lyon
Sponsor class: OTHER
First posted: 2013-11-20
Enrollment: 60
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The objective of this study is to compare two surgical procedure to place implant in severely resorbed posterioir part of the maxilla.


Eligibility criteria: Inclusion Criteria:

* 18 years and more
* sinus lift
* enough remaining bone for image guided implant placement

Exclusion Criteria:

* pregnancy
* chronic disease

Primary outcomes:
measure: Treatment success
timeFrame: 2 years
Secondary outcomes:
measure: Accuracy of the image guided system used
timeFrame: During surgery
measure: Treatment success
timeFrame: 5 years
measure: Replacement of missing teeth
timeFrame: 4 month after surgery
measure: Angulation of implant
timeFrame: 4 month after surgery
measure: Cost of treatment
timeFrame: 4 month after surgery
measure: Patient pain
timeFrame: 1 week after implant placement procedure
measure: Patient satisfaction
timeFrame: 1 year after prosthesis loading
Other outcomes:
Locations:
city: Lyon cedex 07
country: France
facility: Hospices Civils de Lyon - Service de Consultations et Traitements Dentaires
Study officials:
affiliation: Hospices Civils de Lyon - Service de Consultations et Traitements Dentaires
name: Thomas FORTIN
role: PRINCIPAL_INVESTIGATOR
References: