Clinical trial NCT06931756: Effects of Uremia on Brachial Plexus Electrophysiology and Brachial Plexus Block
Official title: Effects of Uremia on Brachial Plexus Electrophysiology and Brachial Plexus Block: One Prospective Parallel Cohort Study
Study type: INTERVENTIONAL
Overall status: NOT_YET_RECRUITING
Phase: NA
Conditions: Electrical Stimulation of Nerves Produces Muscle Reflexes
Keywords: Neuron
Muscle movement
Electrical Stimulation
Electric current
Lead sponsor: Nanjing First Hospital, Nanjing Medical University
Sponsor class: OTHER
First posted: 2025-04-17
Enrollment: 60
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NON_RANDOMIZED
Intervention model: PARALLEL
Primary purpose: DIAGNOSTIC

Brief summary: As a late stage of renal failure, uremia not only leads to severe impairment of renal function in patients, but also often leads to a variety of complications, among which multiple peripheral neuropathy is particularly common. This lesion is mainly caused by the combination of multiple mechanisms, such as the accumulation of uremic toxins, electrolyte disorder, nutrient deficiency and factors related to hemodialysis. Therefore, it is important clinical significance to deeply explore the effects of uremia on electrophysiological properties and nerve block of brachial plexus.

At present, there are relatively few studies on the effects of uremia on the brachial plexus, especially the prospective parallel cohort studies on its electrophysiological properties and nerve block. As a new anesthetic technique, ultrasound-guided axillary brachial plexus block has the advantages of precise positioning, scientific administration, reducing complications and improved safety, but the application effect and safety in uremic patients still need to be further verified.


Eligibility criteria: Inclusion Criteria:

* Uremia group \[group U\]

  1. Patients aged 18 years and older
  2. ASA classification I-IV
  3. BMI 18.5-29.9
  4. Patients with uremia planning to undergo forearm or hand surgery
  5. Diagnostic criteria: Patients must meet the internationally recognized diagnostic criteria for uremia and require hemodialysis
  6. Informed consent: Patients or their legal representatives must sign an informed consent form, agreeing to participate in this study and undergo related examinations and treatments
* Non-uremia group \[Group N\]

  1. Patients aged 18 years and older
  2. ASA classification I-IV
  3. BMI 18.5-29.9
  4. Patients planning to undergo forearm or hand surgery
  5. In addition to possibly having diabetes, patients should not have any other diseases that could cause peripheral neuropathy
  6. The patient or their legal representative must sign an informed consent form, agreeing to participate in this study and receive the relevant examinations and treatments

Exclusion Criteria:

* Individuals allergic to study medications (such as ropivacaine)
* Those with contraindications to local anesthesia or nerve blockades, such as coagulation disorders, infections, etc.
* Those with severe cardiovascular or respiratory diseases
* Those unable to comply with study requirements, such as cognitive impairment, mental disorders, etc.
* Pregnant women

Primary outcomes:
measure: The difference in the minimum excitatory threshold current for motor electrical stimulation of the radial, ulnar, median, and musculocutaneous nerves between patients with uremia and those without uremia.
timeFrame: one year
Secondary outcomes:
measure: The onset time of forearm sensory block in two groups of patients
timeFrame: one year
measure: Onset time of forearm motor block in two groups of patients
timeFrame: one year
measure: The recovery time of forearm sensation in two groups of patients
timeFrame: one year
measure: Recovery time for forearm movement in two groups of patients
timeFrame: one year
Other outcomes:
Locations:
Study officials:
References: