louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT02504437: Therapy of Preconditioned Autologous BMMSCs for Patients With Ischemic Heart Disease
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: PHASE1
PHASE2
Conditions: Myocardial Infarction
Acute Myocardial Infarction
Ischemic Cardiomyopathy
Lead sponsor: Academy Military Medical Science, China
Sponsor class: INDUSTRY
Collaborators: name: Sun Yat-sen University
First posted: 2015-07-22
Enrollment: 200
Sex: ALL
Maximum age (years): 75
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The purpose of the present study is to evaluate the efficacy of the preconditioned autologous bone marrow mesenchymal stem cells for patients with ischemic heart diseases.


Eligibility criteria: Inclusion Criteria:

* Age under 75;
* Clinical diagnosis of acute Myocardial Infarction, chronic Myocardial Infarction and Ischemic Cardiomyopathy
* NYHA (New York Heart Association) grade: III-IV, LVEF (left ventricular ejection fraction): 25-50%;
* No infection diseases including HBV (hepatitis B virus), HCV (hepatitis C virus ), syphilis and AIDS;
* No psychiatric illnesses and speaking dysfunction;
* Informed consent.

Exclusion Criteria:

* More than 75 years old;
* LVEF\<24%;
* Unstable hemodynamics, shock;
* Severe infection;
* Patients have tumor or other lethal diseases (expectation of life\<6 months);
* Radiation patients;
* hematopoietic malignancy including Haemophiliacs;
* Anemia (Hb\<100g/L);
* The other clinical trial participants within one month;
* Abnormal increasing of the blood biochemical indicators that is not explained by the conditions;
* Informed refusal.

Primary outcomes:
measure: LVEF (left ventricular ejection fraction)
timeFrame: one year
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
References:
citation: Gao LR, Pei XT, Ding QA, Chen Y, Zhang NK, Chen HY, Wang ZG, Wang YF, Zhu ZM, Li TC, Liu HL, Tong ZC, Yang Y, Nan X, Guo F, Shen JL, Shen YH, Zhang JJ, Fei YX, Xu HT, Wang LH, Tian HT, Liu DQ, Yang Y. A critical challenge: dosage-related efficacy and acute complication intracoronary injection of autologous bone marrow mesenchymal stem cells in acute myocardial infarction. Int J Cardiol. 2013 Oct 9;168(4):3191-9. doi: 10.1016/j.ijcard.2013.04.112. Epub 2013 May 4.
Clinical trial NCT06739837: Comparison of the Effect of a Non-immersive VRE and CT in Patients With Tennis Elbow
Official title: Comparison of the Effect of a Non-immersive Virtual Reality Environment and Conventional Treatment in Patients With Tennis Elbow
Study type: INTERVENTIONAL
Overall status: ACTIVE_NOT_RECRUITING
Phase: NA
Conditions: Tennis Elbow
Lead sponsor: Superior University
Sponsor class: OTHER
First posted: 2024-12-18
Enrollment: 40
Sex: ALL
Minimum age (years): 20
Maximum age (years): 25
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: HEALTH_SERVICES_RESEARCH

Brief summary: This study investigates the comparative effectiveness of non-immersive virtual reality (VR) therapy and conventional physiotherapy in managing tennis elbow (lateral epicondylitis). Tennis elbow is a painful condition often characterized by chronic pain, reduced grip strength, and limited functionality.

Detailed description: Conventional treatment approaches, including manual therapy and strengthening exercises, have been widely used but may not fully address the long-term rehabilitation needs of every patient. Virtual reality, an emerging tool in rehabilitation, has the potential to enhance patient engagement and adherence by providing an interactive therapeutic environment. Participants will be divided into two groups: one receiving VR therapy and the other conventional therapy, with each intervention lasting six weeks. Outcome measures include pain intensity (VAS), functional disability (DASH), patient satisfaction (PRTEE), grip strength, range of motion (ROM), and adherence rates. This study aims to determine if VR therapy can offer superior benefits over conventional

Eligibility criteria: Inclusion Criteria:

* Adults aged 25 to 50 years.
* Patient diagnosis with lateral epicondylitis.
* Patients that a medical doctor will be formally diagnosed to have tennis elbow, that is, lateral epicondylitis.
* Patients who have specific pain and function impairment associated with tennis elbow.
* Patients giving written consent to participate in the study. Willing to participate and provide informed consent.

Exclusion Criteria:

* Patients with neurological conditions whereby they have abnormal functioning of their arms.
* Any previous surgical intervention for tennis elbow The presence of other significant musculoskeletal diseases in the upper extremity Severe cardiovascular or neurological disorders.

Primary outcomes:
measure: Visual Analog Scale (VAS)
timeFrame: 12 Months
measure: Handheld Dynamometer
timeFrame: 12 Months
Secondary outcomes:
Other outcomes:
Locations:
city: Kashmir
country: Pakistan
facility: Samahni, Near thq hospital samahni azad kashmir
state: Azad Kashmir
Study officials:
References:
Clinical trial NCT06219837: Subarachnoid Block Versus Ultrasound Guided Transversalis Fascia Plane Block for Postoperative Analgesia of Inguinal Hernia Repair in Adults
Official title: Subarachnoid Block Versus Ultrasound Guided Transversalis Fascia Plane Block for Postoperative Analgesia of Inguinal Hernia Repair in Adults: A Randomized, Double Blinded, Controlled Trial
Study type: INTERVENTIONAL
Overall status: RECRUITING
Phase: NA
Conditions: Postoperative Analgesia of Inguinal Hernia Repair in Adults
Lead sponsor: Cairo University
Sponsor class: OTHER
First posted: 2024-01-23
Enrollment: 80
Sex: ALL
Minimum age (years): 18
Maximum age (years): 65
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: OTHER

Brief summary: The aim of our study is to investigate the effect of the ultrasound guided transversalis fascia plane block on the postoperative opioid consumption as a part of multimodal analgesia in patients undergoing inguinal herniorrhaphy under spinal anesthesia.

Detailed description: The aim of our study is to investigate the efficacy of the ultrasound-guided transversalis fascia plane block as a postoperative analgesia as a part of multimodal analgesia in patients undergoing inguinal herniorrhaphy under spinal anesthesia.

The ultrasound (US)-guided transversalis fascia plane (TFP) block was first described by Hebbard in 2009. A local anesthetic (LA) injected between the transversus abdominis muscle, and its deep investing fascia will block the anterior and the lateral branches of the T12 and L1 nerves (4). The efficacy of this block has been demonstrated in iliac crest bone graft harvesting, caesarean section and inguinal herniorrhaphy

Eligibility criteria: Inclusion Criteria:

* Patients undergoing inguinal herniorrhaphy.
* Patients 18-60 years.
* ASA I and II.
* Both sexes.
* Having no contraindication for spinal anesthesia or TFP block.

Exclusion Criteria:

* Refusal of regional anesthesia.
* Infection in the back or at the site of injection for TFP block.
* INR \> 1.5.
* Platelet count \< 80000 per microliter of blood.
* Patients known to be allergic to amide local anesthetics.
* BMI greater than 35 kgm_2.
* Opioid addiction.
* Have communication problems that may hinder the assessement of pain postoperative.

Primary outcomes:
measure: The total amount of postoperative morphine consumption during the first 24hrs postoperative.
timeFrame: First 24 hours postoperative
Secondary outcomes:
Other outcomes:
Locations:
city: Cairo
country: Egypt
facility: Faculty of Medicine, Cairo University
state: Giza
Study officials:
affiliation: Cairo University
name: Marwa Zayed, Assistant professor
role: STUDY_DIRECTOR
affiliation: Cairo University
name: Belal Khater, Master
role: PRINCIPAL_INVESTIGATOR
affiliation: Cairo University
name: Mohamed Mohamed, MD
role: STUDY_DIRECTOR
References:
Clinical trial NCT02383537: Biological Changes in the Adipose Tissue Among Pregnant Women With Diabetes
Official title: Biological Changes in the Adipose Tissue (RNA Profile) Among Pregnant Women With Diabetes
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Pregnancy
Diabetes
Lead sponsor: Hadassah Medical Organization
Sponsor class: OTHER
First posted: 2015-03-09
Enrollment: 150
Sex: FEMALE
Minimum age (years): 18
Maximum age (years): 45
Standard ages: ADULT
Accepts healthy volunteers: yes
Observational model: CASE_CONTROL
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: Pregnant women with diabetes. Healthy women will serve as a reference group

Brief summary: The aim of the research is to study the effect of miRNA, fat tissue and insulin resistance on the pathophysiology of diabetes during pregnancy. During the study fat tissue, Umbilical cord blood, placenta tissue and subcutaneous fat will be taken from pregnant diabetic woman over going a C-section. Healthy pregnant women will serve as a control group.

Detailed description: The aim of the research is to study the effect of miRNA, fat tissue and insulin resistance on the pathophysiology of diabetes during pregnancy. During the study:

1. fat tissue, Umbilical cord blood, placenta tissue and subcutaneous fat will be taken from pregnant diabetic woman over going a C-section.
2. Bloods will be analyzed for insulin, c-peptide, glucose and fat profile
3. Placenta and fat tissue will be analyzed for miRNA and total RNA
4. Clinical and anthropometric measurements will be taken from the mother
5. Placenta status will be taken

Eligibility criteria: Inclusion Criteria:

* age 18-45
* pregnant
* signed consent form
* going through an elective C-section
* Diabetic
* reference group: healthy women with no background illness

Exclusion Criteria:

* \<18 or \>45
* chronic illness that may effect the outcome
* polypharmacy

Primary outcomes:
measure: miRNA profiling
timeFrame: samles are taken during C-section samples will be analyzed after completion of collection
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
affiliation: Hadassah Ein Keren
name: Uriel Elchalal, Professor
role: PRINCIPAL_INVESTIGATOR
affiliation: Hebrew University
name: Ram Weiss, Professor
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT00724737: Presurgical Planning With Functional MRI (fMRI) Mapping of Motor Cortex in Patients With Cerebral Tumors
Official title: Presurgical Planning With Motion Corrected fMRI Mapping of Motor Cortex in Patients With Cerebral Tumors
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Brain Tumors
Lead sponsor: University of Michigan
Sponsor class: OTHER
Collaborators: name: National Cancer Institute (NCI)
name: National Institutes of Health (NIH)
First posted: 2008-07-29
Enrollment: 23
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: NON_RANDOMIZED
Intervention model: SINGLE_GROUP
Primary purpose: DIAGNOSTIC

Brief summary: The purpose of this study is to determine if functional MRI is precise enough to provide information about the location of brain functions in patients who have brain tumors. This might allow physicians to use a non-invasive procedure to assist with brain mapping prior to surgery

Detailed description: The purpose of this study is to determine if fMRI is precise enough to be used in preoperative decision making for patients who have brain tumors. Before a patient has brain surgery to have the tumor removed, functional mapping of the brain takes place either intra-operatively or post operatively after a subdural grid implant has been placed. Mapping helps the surgeon determine which areas of the brain are responsible for different important body functions. During this mapping procedure the surgeon determines if they can safely remove all or part of a brain tumor. The investigators are hoping to show that fMRI is just as accurate in mapping out different areas of the brain, without having to utilize an invasive form of brain mapping.

Eligibility criteria: Inclusion Criteria:

* All patients with brain tumors and healthy volunteers

Exclusion Criteria:

* If patients are pregnant.
* If patients suffer from a significant degree of claustrophobia.
* If patients are claustrophobic and requires general anesthesia to complete the diagnostic MRI.
* Contraindications for an MRI due to surgeries and/or implantation of pacemakers or pacemaker wires, open heart surgery for placement of an artificial heart valve, brain aneurysm surgery, middle ear implants, hearing aids, braces or extensive dental work, cataract surgery or lens implant, any implanted mechanical or electrical device, implanted neurological stimulators or artificial limbs or joints.
* Contraindications from an MRI due to foreign metallic objects in the body such as: bullets, BBs, pellets, surgical magnetic metal clips, joint or bone pins, metal plates, shrapnel or any one who has a history of working near metal who could have metal shavings in their eyes.

Primary outcomes:
measure: Determining whether fMRI mapping is as effective as invasive presurgical mapping.
timeFrame: 2 weeks
Secondary outcomes:
Other outcomes:
Locations:
city: Ann Arbor
country: United States
facility: University of Michigan Health System
state: Michigan
Study officials:
affiliation: University of Michigan
name: Boklye Kim, M.D.
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT00481637: Study to Evaluate Immune Responses in Neurologically Normal Cancer Patients
Official title: Tumor Immunity in Neurologically Normal Patients
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Cancer
Keywords: paraneoplastic; autoimmunity;
Lead sponsor: Rockefeller University
Sponsor class: OTHER
First posted: 2007-06-04
Enrollment: 33
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: CASE_CONTROL
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Patients with SCLC and gynecologic (breast or ovarian) tumors and patients with unrelated cancers. Also healthy volunteers will be included as a comparison group in this study.

Brief summary: The purpose of this study is to study whether immune cells capable of killing tumors that express proteins associated with paraneoplastic neurologic syndrome (PNS) can be found in small cell lung cancer and ovarian cancer patients. The presence of these cells may play a role in tumor immunity in these patients. The protocol involves neurological examinations and collection of blood.

Detailed description: See brief description

Eligibility criteria: Inclusion Criteria:

1. Males and females ages 25 -75
2. If leukapheresis:

   Hepatitis B surface antigen negative if tested\* Hepatitis C antibody negative if tested\* HIV antibody negative if tested\* Venereal disease reaction level (VDRL) negative if tested\* No known IV drug users Hemoglobin \> 8.5 White blood cell count \> 3,800 Platelets \> 120,000 International normalized ratio (INR) \< 2 (verified only if clinically indicated)
3. If large blood draw (1/2 to 1 unit) in lieu of leukapheresis:

Hepatitis B surface antigen negative if tested\* Hepatitis C antibody negative if tested\* HIV antibody negative if tested\* VDRL negative if tested\* No known IV drug users HgB \> 10.0 WBC \> 3,800 Platelets \> 120,000 INR \< 2 (verified only if clinically indicated)

Exclusion Criteria:

No known neurologic disease 2. No known central nervous system (CNS) metastasis on clinical exam 3. No chemotherapy within 1 month 4. No New York Heart Association class III/IV status 5. No pulmonary disease which limits daily activities 6. No anticoagulation therapy

Primary outcomes:
measure: Paraneoplastic neoplastic disease antibody titer, Cytotoxic T Lymphocyte activity, and clinical data in neurologically normal patients with small cell lung cancer and gynecologic tumors, with tumors unrelated to PNDs, and in normal control patients.
timeFrame: Duration of study
Secondary outcomes:
Other outcomes:
Locations:
city: New York
country: United States
facility: Rockefeller University Hospital
state: New York
Study officials:
affiliation: Rockefeller University
name: Robert Darnell, MD, PHD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT03588637: Real-world Daptomycin Use in Chinese ICUs
Official title: Real-world Effectiveness and Safety on Daptomycin in Gram-Positive Infections in Chinese Intensive Care Units
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Daptomycin
Real-world Study
Intensive Care Unit
Lead sponsor: West China Hospital
Sponsor class: OTHER
First posted: 2018-07-17
Enrollment: 200
Sex: ALL
Minimum age (years): 1
Maximum age (years): 100
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: OTHER
Time perspective: OTHER
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Patient who are suspected of Gram-positive infection in the Intensive Care Units.

Brief summary: Analyze the effectiveness and safety of Daptomycin(Jiangsu Hengrui Medicine Co., Ltd) in Gram-positive infections in Chinese Intensive Care Units by using the real-world data platform, https://rws.scccmqc.com. Patients who received at least one dose of Daptomycin between 2016 to 2021 are eligible.


Eligibility criteria: Inclusion Criteria:

* Patient who received at least one dose of daptomycin

Exclusion Criteria:

* No

Primary outcomes:
measure: mortality
timeFrame: 30 days
measure: Cure Rate
timeFrame: 30 days
Secondary outcomes:
measure: Number of participants with treatment-related adverse events
timeFrame: 30 days
Other outcomes:
Locations:
city: Chengdu
country: China
facility: West China Hospital
state: Sichuan
Study officials:
References:
Clinical trial NCT03475537: tDCS in Patients With Disorders of Consciousness
Official title: The Usage of tDCS in Patients With Disorders of Consciousness
Study type: INTERVENTIONAL
Overall status: WITHDRAWN
Phase: NA
Conditions: Consciousness Disorder
Transcranial Direct Current Stimulation
Lead sponsor: First Affiliated Hospital of Zhejiang University
Sponsor class: OTHER
First posted: 2018-03-23
Enrollment: 0
Sex: MALE
Minimum age (years): 18
Maximum age (years): 80
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: TREATMENT

Brief summary: test

Detailed description: Neurostimulation techniques such as deep brain stimulation (DBS) and spinal cord stimulation (SCS) have been used to treat DOC. Although these techniques have been shown to increase patient response, there are still some limitations. For example, DBS requires craniotomy and may increase the risk of intracranial hemorrhage and infection. In addition, the complexity and cost of these technologies also limit their potential applications.

Eligibility criteria: Inclusion Criteria:

Patients with DOC: VS and MCS (the cause of unification is: traumatic brain injury, the course of more than 1 month, not more than 1 year ; age 18-65; Past history without a mental disorder; No previous alcohol or substance abuse; No epilepsy or frequent spontaneous movement; No benzodiazepines; No moderate or severe hydrocephalus, All patients were right handed.

Exclusion Criteria:

Exclusion of organic heart disease, such as sinus bradycardia, arrhythmia; exclusion of patients with intracranial metal devices, pacemakers or any other device.

Primary outcomes:
measure: improvement of CRS-R
timeFrame: 7 days
Secondary outcomes:
Other outcomes:
Locations:
city: Hangzhou
country: China
facility: The First Affiliated Hospital, Zhejiang University
state: Zhejiang
Study officials:
affiliation: Department of Neurology and Brain Medical Centre The First Affiliated Hospital, School of Medicine, Zhejiang University 79 Qingchun Road, Hangzhou
name: Benyan Luo
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT04910737: Safety and Effectiveness of Extended Circumferential Decompression for Thoracic Ossification of Posterior Longitudinal Ligament
Official title: Safety and Effectiveness of Extended Circumferential Decompression for Thoracic Ossification of Posterior Longitudinal Ligament：a Single-center Experience
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Indications and Effectiveness for Extended Posterior Circumferential Decompression
Keywords: circumferential decompression
thoracic ossification of posterior longitudinal ligament
kyphosis
neurological outcomes
Lead sponsor: Second Affiliated Hospital, School of Medicine, Zhejiang University
Sponsor class: OTHER
First posted: 2021-06-02
Enrollment: 30
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: CASE_ONLY
Time perspective: RETROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: No limit

Brief summary: The study was to evaluate the indications, efficiency and safety of the extended posterior circumferential decompression technique for the treatment of thoracic ossification of posterior longitudinal ligament (TOPLL) with dura adhesions or ossification.

Detailed description: The clinical characteristics of patients with TOPLL combined with dura adhesions who underwent extended circumferential decompression in our hospital were retrospectively investigated. TOPLL adhered with dura matter or dura ossification were detected intraoperatively in all the cases. Imaging evaluation included the ossification-kyphosis angle and the fixed-segment kyphosis angle. A modified Japanese Orthopedic Association Score (JOA score) was applied for the evaluation of clinical outcomes.

Eligibility criteria: Inclusion Criteria: (1) thoracic myelopathy caused by TOPLL with or without TOLF; (2) severe adhesions between dura mater and ossified lesion with or without dura ossification confirmed intraoperatively; (3) extended posterior circumferential decompression was applied; (4) pedicle screw instrumentations were implanted after decompression; (5) follow-up for more than 6 months; (7) complete clinical data.

Exclusion Criteria:

(1) spinal deformities; (2) thoracic spine fractures; (3) syringomyelia, spinal tumor, myelitis, etc.; (4) coexisted with cervical spondylosis and lumbar stenosis; (5) post operation of thoracic spinal stenosis; (6) recurrent myelopathy caused by lesions in other levels than the decompressed segments.

Primary outcomes:
measure: A modified Japanese Orthopedic Association Score
timeFrame: 2 years
Secondary outcomes:
Other outcomes:
Locations:
city: Hangzhou
country: China
facility: Second affiliated hospital of Zhejiang University, School of medicine
state: Zhejiang
Study officials:
affiliation: Second affiliated hospital of medicine, Zhejiang University
name: Ruofu Tang
role: STUDY_DIRECTOR
References: