Clinical trial NCT06682585: Nutritional Status and Therapy in DMD Patients
Official title: Determination of Nutritional Status of Duchenne Muscular Dystrophy Patients and Evaluation of the Effectiveness of Disease-Specific Nutrition Therapy
Study type: INTERVENTIONAL
Overall status: NOT_YET_RECRUITING
Phase: NA
Conditions: Duchenne Muscular Dystrophy (DMD)
Keywords: Duchenne Muscular Dystrophy
Nutrition
Lead sponsor: Ankara University
Sponsor class: OTHER
First posted: 2024-11-12
Enrollment: 10
Sex: MALE
Minimum age (years): 48
Maximum age (years): 96
Standard ages: CHILD
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: SUPPORTIVE_CARE

Brief summary: Brief Summary

The goal of this clinical trial is to evaluate the impact of a disease-specific, individualized diet on the nutritional status and functional abilities of Duchenne muscular dystrophy (DMD) patients. The study will focus on children aged 4-8 years residing in Ankara, Turkey.

Key questions the investigators aim to answer:

Can a tailored dietary intervention improve the nutritional status of DMD patients? Does a specialized diet positively impact the functional abilities of DMD patients, as measured by the North Star Ambulation Assessment (NSAA)? Participants will undergo a comprehensive nutritional assessment, including anthropometric measurements, and will receive individualized dietary counseling. The intervention will focus on optimizing energy, protein, calcium, and fluid intake, as well as addressing the potential side effects of corticosteroid therapy.

The primary outcome measure will be changes in nutritional status, as assessed by anthropometric measurements. Secondary outcome measures will include changes in functional abilities as measured by the NSAA and quality of life assessments.

Detailed description: Study Objective This study aims to investigate the efficacy of a disease-specific, individualized dietary intervention in improving the nutritional status and functional abilities of Duchenne Muscular Dystrophy (DMD) patients aged 4-8 years residing in Ankara, Turkey.

Study Design This is a prospective, interventional study. Intervention

A 12-week individualized dietary intervention will be implemented for each participant. The intervention will focus on:

* Energy Intake: Caloric needs will be calculated based on the patient's age, weight, and activity level, taking into account the potential impact of corticosteroid therapy on energy expenditure.
* Protein Intake: Protein requirements will be met through a balanced diet, aiming to optimize muscle protein synthesis.
* Calcium and Vitamin D Intake: Adequate intake of these nutrients will be emphasized to support bone health and prevent osteoporosis.
* Fluid Intake: Fluid intake will be monitored to prevent dehydration and constipation.
* Carbohydrate Intake: A low-glycemic index diet will be recommended to manage blood glucose levels and insulin resistance, especially in patients on corticosteroid therapy.
* Sodium Intake: Sodium intake will be restricted to minimize fluid retention and hypertension.

Outcome Measures Changes in anthropometric measurements (body weight, height, BMI, skinfold measurements) Changes in functional abilities as assessed by the North Star Ambulation Assessment (NSAA) Changes in functional abilities as assessed by handgrip strenght Changes in micro and micro nutrient intake as assessed by three-day food consumption record Data Collection Data will be collected through face-to-face interviews with parents or primary caregivers and patients with DMD. After the first interview, a second interview will be conducted 12 weeks after the personalized diet has been planned.

Baseline Assessment:

* Demographic information
* Medical history
* Nutritional assessment (anthropometric measurements, dietary intake assessment)
* Functional assessment (NSAA)

Follow-up Assessments:

* Anthropometric measurements
* Functional assessment (NSAA)
* Dietary intake assessment Data Analysis Statistical analysis will be performed using appropriate statistical software. Descriptive statistics will be used to summarize the baseline characteristics of the participants. Parametric or non-parametric tests will be used to compare pre- and post-intervention outcomes, as appropriate.

Ethical Considerations The study will be conducted in accordance with the Declaration of Helsinki and approved by the local ethics committee. Informed consent will be obtained from the parents or legal guardians of the participants.

By addressing the specific nutritional needs of DMD patients, this study aims to improve their overall health and quality of life.

Eligibility criteria: Inclusion Criteria:

Clinical diagnosis of Duchenne Muscular Dystrophy (DMD) Must be between 4 and 8 years old Able to ambulate independently Must be residing in Ankara province, Turkey Must be willing to participate and adhere to the dietary intervention, as confirmed by both the patient and their legal guardian(s) Must be currently receiving corticosteroid therapy

Exclusion Criteria:

Inability to read and write in Turkish Wheelchair-bound or unable to ambulate independently Significant liver or kidney dysfunction Scheduled for major surgery within 6 months of study enrollment Symptoms of dysphagia and swallowing difficulties Significant respiratory distress or respiratory insufficiency requiring mechanical ventilation.

Primary outcomes:
measure: Anthropometric measurements
timeFrame: From enrollment to the end of diet at 12 weeks
measure: Anthropometric measurements
timeFrame: From enrollment to the end of diet at 12 weeks
measure: Anthropometric measurements
timeFrame: From enrollment to the end of diet at 12 weeks
measure: Anthropometric measurements
timeFrame: From enrollment to the end of diet at 12 weeks
Secondary outcomes:
measure: Functional Ability
timeFrame: From enrollment to the end of diet at 12 weeks
measure: Functional Ability
timeFrame: From enrollment to the end of diet at 12 weeks
Other outcomes:
measure: Dietary Adherence
timeFrame: From enrollment to the end of diet at 12 weeks
Locations:
city: Ankara
country: Turkey
facility: DMD Aileleri Derneği
state: Çankaya
Study officials:
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