Clinical trial NCT03891511: TMJ Fibrocartilage Detection Using MRI
Official title: TMJ Fibrocartilage Detection Using 3D Fat-Suppressed Spoiled Gradient-Echo Magnetic Resonance Imaging
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: TMJ Disorders
MRI Scans
Lead sponsor: Universidad de los Andes, Chile
Sponsor class: OTHER
Collaborators: name: Universidad Mayor
name: University of Chile
First posted: 2019-03-27
Enrollment: 59
Sex: ALL
Minimum age (years): 18
Maximum age (years): 60
Standard ages: ADULT
Accepts healthy volunteers: yes
Observational model: CASE_ONLY
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: participants will be whites, urban, low , medium low and médium socioeconomic level, from Santiago, Chile.

Brief summary: Objective: The aims of this study will be to detect the fibrocartilage layer (FC) of the human temporomandibular joint (TMJ) using 3D SPGR (Spoiled GRASS sequence) (T1 WATS) sequence and to compare these results with those of conventional magnetic resonance imaging (DP, T2 MRI) sequences in patients with temporomandibular disorders (TMD).

Detailed description: This prospective and observational study will focused on analyzing morphological characteristics of the fibrocartilage layer of the TMJ based on the MRI scans of 59 patients. All 118 TMJs of these patients will be suitable for analysis, (range: 18-60 years old), females and males affected by TMD and did not undergo previous TMJ treatment.

Eligibility criteria: Inclusion Criteria:

\* Internal derangement in theTMJ

Exclusion Criteria:

* Cardiac pacemaker
* Cochlear implant
* Intracranial vascular clips
* Metal particles in the orbit
* Head or face trauma
* Gout
* Generalized osteoarthrosis
* Joint hyperlaxity
* Congenital malformity
* Facial cysts
* Facial tumors
* Previous TMJ surgery

Primary outcomes:
measure: Presence of the TMJ Fibrocartilage layer
timeFrame: six months
measure: Discontinuity of the TMJ FC layer
timeFrame: six months
measure: Fibrocartilage Signal Intensity
timeFrame: six month
measure: Thickness of the TMJ fibrocartilage layer
timeFrame: Six months
measure: Length of the TMJ fibrocartilage layer
timeFrame: Six moths
measure: Statistical analysis
timeFrame: seven months
Secondary outcomes:
Other outcomes:
Locations:
city: Santiago
country: Chile
facility: San Vicente de Paul Centro de Diagnóstico
Study officials:
affiliation: UAndes, Santiago, Chile
name: Gustavo Moncada, PhD
role: PRINCIPAL_INVESTIGATOR
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