Clinical trial NCT02528188: Long Term Safety and Efficacy Study of Tanezumab in Subjects With Osteoarthritis of the Hip or Knee
Official title: A PHASE 3 RANDOMIZED, DOUBLE-BLIND, ACTIVE-CONTROLLED, MULTICENTER STUDY OF THE LONG-TERM SAFETY AND EFFICACY OF SUBCUTANEOUS ADMINISTRATION OF TANEZUMAB IN SUBJECTS WITH OSTEOARTHRITIS OF THE HIP OR KNEE
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE3
Conditions: Chronic Pain
Osteoarthritis, Hip
Osteoarthritis, Knee
Lead sponsor: Pfizer
Sponsor class: INDUSTRY
First posted: 2015-08-19
Enrollment: 3021
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The purpose of this study is to compare the long-term joint safety and efficacy (pain relief) of the investigational study drug, tanezumab compared to non-steroidal anti inflammatory drugs (NSAIDs) in subjects with osteoarthritis of the hips or knees.


Eligibility criteria: Inclusion Criteria:

* A diagnosis of osteoarthritis of the index hip or knee based on American College of Rheumatology criteria with Kellgren Lawrence X ray Grade of 2 as diagnosed by the Central Reader
* Currently receiving a stable dose regimen of oral NSAID (naproxen, celecoxib, diclofenac, aceclofenac, loxoprofen, ibuprofen, meloxicam, nabumetone, sulindac or ketoprofen) as described in the protocol along with a history of insufficient pain relief from, inability to tolerate or contraindication to taking acetaminophen and, tramadol or opioid treatments. Subjects must also maintain a stabilized, protocol specified NSAID dose regimen for at least the final 2 or 3 weeks of the Screening period
* WOMAC Pain subscale score of at least 5 in the index knee or hip at Screening
* Be willing to discontinue all non study pain medications for osteoarthritis and not use prohibited pain medications throughout the duration of the study
* Female subjects of childbearing potential must agree to comply with protocol specified contraceptive requirements

Exclusion Criteria:

* Subjects exceeding protocol defined BMI or body weight limits
* History of other diseases specified in the protocol (eg, inflammatory joint diseases, crystalline diseases such as gout or pseudogout) that may involve the index joint and that could interfere with efficacy assessments
* Radiographic evidence of protocol specified bone or joint conditions in any screening radiograph as determined by the central radiology reviewer
* A history of osteonecrosis or osteoporotic fracture
* History of significant trauma or surgery to a knee, hip or shoulder within the previous year
* Planned surgical procedure during the duration of the study
* Presence of conditions (eg, fibromyaliga, radiculopathy) associated with moderate to severe pain that may confound assessments or self evaluation of osteoarthritis pain
* Signs or symptoms of carpal tunnel syndrome in the year prior to Screening
* Considered unfit for surgery based upon American Society of Anesthesiologists physical classification system for surgery grading, or subjects who would not be willing to undergo joint replacement surgery if required
* Contraindications to magnetic resonance imaging
* History of intolerance or hypersensitivity to the oral NSAID (naproxen, celecoxib or diclofenac) the subject could be randomized to receive or any of its excipients or existence of a medical condition or use of concomitant medication for which the use of this NSAID is contraindicated
* History of intolerance or hypersensitivity to acetaminophen or any of its excipients or existence of a medical condition or use of concomitant medication for which the use of acetaminophen is contraindicated
* Use of prohibited medications without the appropriate washout period prior to Screening or Initial Pain Assessment Period
* History of cancer within 5 years of Screening, except for cutaneous basal cell or squamous cell cancer resolved by excision
* Subjects with signs and symptoms of clinically significant cardiac disease as described in the protocol
* Diagnosis of a transient ischemic attack in the 6 months prior to Screening, diagnosis of stroke with residual deficits that would preclude completion of required study activities
* History, diagnosis, or signs and symptoms of clinically significant neurological disease such as but not limited to peripheral or autonomic neuropathy
* History, diagnosis, signs or symptoms of any clinically significant psychiatric disorder
* History of known alcohol, analgesic or drug abuse within 2 years of Screening
* Previous exposure to exogenous NGF or to an anti-NGF antibody
* History of allergic or anaphylactic reaction to a therapeutic or diagnostic monoclonal antibody or IgG fusion protein
* Poorly controlled hypertension as defined in the protocol or taking an antihypertensive that has not been stable for at least 1 month prior to Screening
* Evidence of protocol defined orthostatic hypotension at Screening
* Disqualifying score on the Survey of Autonomic Symptoms questionnaire at Screening
* Screening AST, ALT, serum creatinine or HbA1c values that exceed protocol defined limits
* Presence of drugs of abuse in screening urine toxicology panel
* Positive hepatitis B, hepatitis C or HIV test results indicative of current infection
* Participation in other investigational drug studies within protocol defined time limits
* Pregnant, breastfeeding or female subjects of childbearing potential who are unwilling or unable to follow protocol required contraceptive requirements
* Other severe acute or chronic medical or psychiatric condition or laboratory abnormality that in the judgment of the investigator, would make the subject inappropriate for entry into this study

Primary outcomes:
measure: Percentage of Participants With Adjudicated Primary Composite Joint Safety Outcome
timeFrame: Baseline up to Week 80
measure: Observation Time-Adjusted Event Rate of Participants With Adjudicated Primary Composite Joint Safety Outcome
timeFrame: Baseline up to Week 80
measure: Change From Baseline in Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) Pain Subscale at Week 16
timeFrame: Baseline, Week 16
measure: Change From Baseline in Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) Physical Function Subscale at Week 16
timeFrame: Baseline, Week 16
measure: Change From Baseline in Patient's Global Assessment (PGA) of Osteoarthritis at Week 16
timeFrame: Baseline, Week 16
Secondary outcomes:
measure: Percentage of Participants With Adjudicated Secondary Composite Joint Safety Outcome
timeFrame: Baseline up to Week 80
measure: Observation Time-Adjusted Event Rate of Participants With Adjudicated Secondary Composite Joint Safety Outcome
timeFrame: Baseline up to Week 80
measure: Percentage of Participants With Individual Adjudicated Joint Safety Outcome
timeFrame: Baseline up to Week 80
measure: Observation Time-Adjusted Event Rate of Participants With Individual Adjudicated Joint Safety Outcome
timeFrame: Baseline up to Week 80
measure: Percentage of Participants With Total Joint Replacement or Adjudicated Primary Composite Joint Safety Outcome
timeFrame: Baseline up to Week 80
measure: Observation Time-Adjusted Event Rate of Participants With Total Joint Replacement or Adjudicated Primary Composite Joint Safety Outcome
timeFrame: Baseline up to Week 80
measure: Change From Baseline in Medial or Lateral Joint Space Width of the Index Knee (Kellgren-Lawrence Grade 2 or 3) at Weeks 56 and 80
timeFrame: Baseline, Weeks 56 and 80
measure: Change From Baseline in Joint Space Width of the Index Hip (Kellgren-Lawrence Grade 2 or 3) at Weeks 56 and 80
timeFrame: Baseline, Weeks 56 and 80
measure: Number of Participants With Progression of Osteoarthritis in the Index Knee (Kellgren-Lawrence Grade 2 or 3) According to Bland and Altman Method at Weeks 56 and 80
timeFrame: Weeks 56 and 80
measure: Number of Participants With Progression of Osteoarthritis in the Index Hip (Kellgren-Lawrence Grade 2 or 3) According to Bland and Altman Method at Weeks 56 and 80
timeFrame: Weeks 56 and 80
measure: Change From Baseline in WOMAC Pain Subscale at Weeks 2, 4, 8, 24, 32, 40, 48 and 56
timeFrame: Baseline, Weeks 2, 4, 8, 24, 32, 40, 48 and 56
measure: Change From Baseline in WOMAC Pain Subscale at Week 64
timeFrame: Baseline, Week 64
measure: Change From Baseline in WOMAC Physical Function Subscale at Weeks 2, 4, 8, 24, 32, 40, 48 and 56
timeFrame: Baseline, Weeks 2, 4, 8, 24, 32, 40, 48 and 56
measure: Change From Baseline in WOMAC Physical Function Subscale at Week 64
timeFrame: Baseline, Week 64
measure: Change From Baseline in Patient's Global Assessment (PGA) of Osteoarthritis at Weeks 2, 4, 8, 24, 32, 40, 48 and 56
timeFrame: Baseline, Weeks 2, 4, 8, 24, 32, 40, 48 and 56
measure: Change From Baseline in Patient's Global Assessment (PGA) of Osteoarthritis at Week 64
timeFrame: Baseline, Week 64
measure: Percentage of Participants Meeting Outcome Measures in Arthritis Clinical Trials-Osteoarthritis Research Society International (OMERACT-OARSI) Responder Index at Weeks 2, 4, 8, 16, 24, 32, 40, 48, 56 and 64
timeFrame: Weeks 2, 4, 8, 16, 24, 32, 40, 48, 56 and 64
measure: Percentage of Participants Achieving Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) Pain Subscale Reduction >=30 Percent (%), >=50%, >=70% and >=90% Response at Weeks 2, 4, 8, 16, 24, 32, 40, 48, 56 and 64
timeFrame: Weeks 2, 4, 8, 16, 24, 32, 40, 48, 56 and 64
measure: Percentage of Participants With Cumulative Percent Change From Baseline in Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) Pain Subscale at Weeks 16, 24 and 56
timeFrame: Baseline, Weeks 16, 24 and 56
measure: Percentage of Participants Achieving Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) Physical Function Subscale Reduction of >=30%, >=50%, >=70% and >=90% Response at Weeks 2, 4, 8, 16, 24, 32, 40, 48, 56 and 64
timeFrame: Weeks 2, 4, 8, 16, 24, 32, 40, 48, 56 and 64
measure: Percentage of Participants With Cumulative Percent Change From Baseline in Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) Physical Function Subscale at Weeks 16, 24 and 56
timeFrame: Baseline, Weeks 16, 24 and 56
measure: Percentage of Participants Achieving Improvement of >=2 Points in Patient's Global Assessment (PGA) of Osteoarthritis at Weeks 2, 4, 8, 16, 24, 32, 40, 48, 56 and 64
timeFrame: Weeks 2, 4, 8, 16, 24, 32, 40, 48, 56 and 64
measure: Change From Baseline in Average Pain Score in the Index Joint at Weeks 1, 2, 3, 4, 6, 8, 10, 12, 16, 20, 24, 32, 40, 48 and 56
timeFrame: Baseline, Weeks 1, 2, 3, 4, 6, 8, 10, 12, 16, 20, 24, 32, 40, 48 and 56
measure: Change From Baseline in Average Pain Score in the Index Joint at Week 64
timeFrame: Baseline, Week 64
measure: Change From Baseline in Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) Stiffness Subscale at Weeks 2, 4, 8, 16, 24, 32, 40, 48 and 56
timeFrame: Baseline, Weeks 2, 4, 8, 16, 24, 32, 40, 48 and 56
measure: Change From Baseline in Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) Stiffness Subscale at Week 64
timeFrame: Baseline, Week 64
measure: Change From Baseline in Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) Average Score at Weeks 2, 4, 8, 16, 24, 32, 40, 48 and 56
timeFrame: Baseline, Weeks 2, 4, 8, 16, 24, 32, 40, 48 and 56
measure: Change From Baseline in Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) Average Score at Week 64
timeFrame: Baseline, Week 64
measure: Change From Baseline in Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) Pain Subscale Item: Pain When Walking on a Flat Surface at Weeks 2, 4, 8, 16, 24, 32, 40, 48 and 56
timeFrame: Baseline, Weeks 2, 4, 8, 16, 24, 32, 40, 48 and 56
measure: Change From Baseline in Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) Pain Subscale Item: Pain When Walking on a Flat Surface at Week 64
timeFrame: Baseline, Week 64
measure: Change From Baseline in Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) Pain Subscale Item: Pain When Going Up or Down Stairs at Weeks 2, 4, 8, 16, 24, 32, 40, 48 and 56
timeFrame: Baseline, Weeks 2, 4, 8, 16, 24, 32, 40, 48 and 56
measure: Change From Baseline in Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) Pain Subscale Item: Pain When Going Up or Down Stairs at Week 64
timeFrame: Baseline, Week 64
measure: Change From Baseline in Work Productivity and Activity Impairment Questionnaire for Osteoarthritis (WPAI:OA) Scores at Weeks 16, 24 and 56
timeFrame: Weeks 16, 24 and 56
measure: Change From Baseline in Work Productivity and Activity Impairment Questionnaire for Osteoarthritis (WPAI:OA) Scores at Week 64
timeFrame: Baseline, Week 64
measure: Number of Participants With Responses to European Quality of Life-5 Dimensions-5 Levels (EQ-5D-5L): Mobility Domain
timeFrame: Baseline, Weeks 8, 16, 24, 40, 56 and 64
measure: Number of Participants With Responses to European Quality of Life-5 Dimensions-5 Levels (EQ-5D-5L): Self-Care Domain
timeFrame: Baseline, Weeks 8, 16, 24, 40, 56 and 64
measure: Number of Participants With Responses to European Quality of Life-5 Dimensions-5 Levels (EQ-5D-5L): Usual Activities Domain
timeFrame: Baseline, Weeks 8, 16, 24, 40, 56 and 64
measure: Number of Participants With Responses to European Quality of Life-5 Dimensions-5 Levels (EQ-5D-5L): Pain/Discomfort Domain
timeFrame: Baseline, Weeks 8, 16, 24, 40, 56 and 64
measure: Number of Participants With Responses to European Quality of Life-5 Dimensions-5 Levels (EQ-5D-5L): Anxiety/ Depression Domain
timeFrame: Baseline, Weeks 8, 16, 24, 40, 56 and 64
measure: European Quality of Life-5 Dimensions-5 Levels (EQ-5D-5L) Overall Health Utility Score/Index Value
timeFrame: Baseline, Weeks 8, 16, 24, 40, 56 and 64
measure: Treatment Satisfaction Questionnaire Medicine Version II (TSQM v.II) Score With Effectiveness, Side Effects, Convenience, and Overall Satisfaction Responses
timeFrame: Weeks 16 and 56
measure: Patient-Reported Treatment Impact Assessment- Modified (mPRTI) Score at Weeks 16 and 56: Participant Global Preference Assessment- What is The Current or Most Recent Treatment You Were Receiving for Osteoarthritis Pain Before Enrolling?
timeFrame: Weeks 16 and 56
measure: Patient Reported Treatment Impact Assessment-Modified (mPRTI) Score at Weeks 16 and 56: Participant Global Preference Assessment- Overall, do You Prefer the Drug That You Received in This Study to Previous Treatment?
timeFrame: Weeks 16 and 56
measure: Patient Reported Treatment Impact Assessment-Modified (mPRTI) Score at Weeks 16 and 56: Participant Willingness to Use Drug Again Assessment- Willing to Use the Same Drug That You Have Received in This Study for Your Osteoarthritis Pain?
timeFrame: Weeks 16 and 56
measure: Number of Participants Who Withdrew Due to Lack of Efficacy
timeFrame: Baseline up to Week 56
measure: Time to Discontinuation Due to Lack of Efficacy
timeFrame: Baseline up to Week 56
measure: Number of Participants Who Took Rescue Medication During Weeks 2, 4, 8, 16, 24, 32, 40, 48 and 56
timeFrame: Weeks 2, 4, 8, 16, 24, 32, 40, 48 and 56
measure: Number of Participants Who Took Rescue Medication During Week 64
timeFrame: Week 64
measure: Number of Days of Rescue Medication Used During Weeks 2, 4, 8, 16, 24, 32, 40, 48 and 56
timeFrame: Weeks 2, 4, 8, 16, 24, 32, 40, 48 and 56
measure: Number of Days of Rescue Medication Used During Week 64
timeFrame: Week 64
measure: Amount of Rescue Medication Used During Weeks 2, 4, 8 and 16
timeFrame: Weeks 2, 4, 8 and 16
measure: Health Care Resource Utilization (HCRU): Number of Visits of Services Directly Related to Osteoarthritis
timeFrame: Baseline, Weeks 64 and 80
measure: Health Care Resource Utilization (HCRU): Number of Participants Who Visited the Emergency Room Due to Osteoarthritis
timeFrame: Baseline, Weeks 64 and 80
measure: Health Care Resource Utilization (HCRU): Number of Visits to the Emergency Room Due to Osteoarthritis
timeFrame: Baseline, Weeks 64 and 80
measure: Health Care Resource Utilization (HCRU): Number of Participants Hospitalized Due to Osteoarthritis
timeFrame: Baseline, Weeks 64 and 80
measure: Health Care Resource Utilization (HCRU): Number of Nights Stayed in the Hospital Due to Osteoarthritis
timeFrame: Baseline, Weeks 64 and 80
measure: Health Care Resource Utilization (HCRU): Number of Participants Who Used Any Aids/Devices for Doing Things Due to Osteoarthritis
timeFrame: Baseline, Weeks 64 and 80
measure: Health Care Resource Utilization (HCRU): Number of Participants Who Quit Job Due to Osteoarthritis
timeFrame: Baseline, Weeks 64 and 80
measure: Health Care Resource Utilization (HCRU): Duration Since Quitting Job Due to Osteoarthritis
timeFrame: Baseline, Weeks 64 and 80
measure: Number of Participants With Categorical Change From Baseline in Lower Extremity Activity Scale (LEAS) at Weeks 4, 8, 16, 24, 56 and 80
timeFrame: Baseline, Weeks 4, 8, 16, 24, 56 and 80
measure: Change From Baseline in Average Daily Minutes of Physical Activity at Weeks 16 and 56
timeFrame: Baseline, Weeks 16 and 56
measure: Change From Baseline in Average Daily Physical Activity Counts at Weeks 16 and 56
timeFrame: Baseline, Weeks 16 and 56
measure: Change From Baseline in Average Daily Minutes of Moderate to Vigorous Physical Activity at Weeks 16 and 56
timeFrame: Baseline, Weeks 16 and 56
measure: Change From Baseline in Average Daily Minutes of Bouted (Sustained) Moderate to Vigorous Physical Activity at Weeks 16 and 56
timeFrame: Baseline, Weeks 16 and 56
measure: Change From Baseline in Average Daily Step Count at Weeks 16 and 56
timeFrame: Baseline, Weeks 16 and 56
measure: Number of Participants With Treatment-Emergent Adverse Events (AEs) and Serious Adverse Events (SAEs)
timeFrame: Baseline up to Week 80
measure: Number of Participants With Treatment-Related Treatment-Emergent Adverse Events (AEs) and Serious Adverse Events (SAEs)
timeFrame: Baseline up to Week 80
measure: Number of Participants With Laboratory Test Abnormalities With Regard to Normal Baseline
timeFrame: Baseline up to Week 80
measure: Number of Participants With Laboratory Test Abnormalities With Regard to Abnormal Baseline
timeFrame: Baseline up to Week 80
measure: Change From Baseline in Blood Pressure (BP) at Weeks 2, 4, 8, 16, 24, 32, 40, 48, 56, 64 and 80
timeFrame: Baseline, Weeks 2, 4, 8, 16, 24, 32, 40, 48, 56, 64 and 80
measure: Change From Baseline in Heart Rate at Weeks 2, 4, 8, 16, 24, 32, 40, 48, 56, 64 and 80
timeFrame: Baseline, Weeks 2, 4, 8, 16, 24, 32, 40, 48, 56, 64 and 80
measure: Change From Baseline in Electrocardiogram (ECG) Parameters at Weeks 56 and 80
timeFrame: Baseline, Weeks 56 and 80
measure: Change From Baseline in Heart Rate (as Assessed by ECG) at Weeks 56 and 80
timeFrame: Baseline, Weeks 56 and 80
measure: Number of Participants With Confirmed Orthostatic Hypotension
timeFrame: Baseline, Weeks 2, 4, 8, 16, 24, 32, 40, 48, 56, 64 and 80
measure: Change From Baseline in Survey of Autonomic Symptom (SAS) Scores at Weeks 24, 56 and 80
timeFrame: Baseline, Weeks 24, 56 and 80
measure: Change From Baseline in Neuropathy Impairment Score (NIS) at Weeks 2, 4, 8, 16, 24, 32, 40, 48, 56, 64 and 80
timeFrame: Baseline, Weeks 2, 4, 8, 16, 24, 32, 40, 48, 56, 64 and 80
measure: Number of Participants With Anti-Tanezumab Antibodies
timeFrame: Baseline, Weeks 8, 16, 32, 48, 56, 64 and 80
Other outcomes:
Locations:
city: Birmingham
country: United States
facility: Central Alabama Research
state: Alabama
city: Birmingham
country: United States
facility: Achieve Clinical Research, LLC
state: Alabama
city: Birmingham
country: United States
facility: Alabama Clinical Therapeutics, LLC
state: Alabama
city: Birmingham
country: United States
facility: Alabama Orthopaedic Surgeons
state: Alabama
city: Huntsville
country: United States
facility: Rheumatology Associates of North Alabama, PC
state: Alabama
city: Mobile
country: United States
facility: Coastal Clinical Research, Inc.
state: Alabama
city: Mesa
country: United States
facility: Ferguson Family Medicine
state: Arizona
city: Phoenix
country: United States
facility: Arizona Arthritis & Rheumatology Associates, P.C.
state: Arizona
city: Phoenix
country: United States
facility: Arizona Research Center
state: Arizona
city: Scottsdale
country: United States
facility: Valley Pain Consultants
state: Arizona
city: Tempe
country: United States
facility: Clinical Research Consortium
state: Arizona
city: Tucson
country: United States
facility: Noble Clinical Research, LLC
state: Arizona
city: Tucson
country: United States
facility: Quality of Life Medical & Research Centers, LLC
state: Arizona
city: Tucson
country: United States
facility: Tucson Orthopaedic Institute - Research Center
state: Arizona
city: Hot Springs
country: United States
facility: CHI St. Vincent Medical Group Hot Springs
state: Arkansas
city: Little Rock
country: United States
facility: Chrystal Johnson
state: Arkansas
city: Little Rock
country: United States
facility: KLR Business Group, Inc., dba Arkansas Clinical Research
state: Arkansas
city: Little Rock
country: United States
facility: Larry Watkins, MD
state: Arkansas
city: Little Rock
country: United States
facility: Lynn Institute of the Ozarks
state: Arkansas
city: Anaheim
country: United States
facility: Orange County Research Institute
state: California
city: Anaheim
country: United States
facility: Advanced Research Center
state: California
city: Bellflower
country: United States
facility: CITrials
state: California
city: Beverly Hills
country: United States
facility: Osteoporosis Medical Center
state: California
city: Canoga Park
country: United States
facility: Hope Clinical Research
state: California
city: Carmichael
country: United States
facility: Med Center
state: California
city: Cerritos
country: United States
facility: Core Healthcare Group
state: California
city: Covina
country: United States
facility: Pleitez Medical Clinic
state: California
city: El Cajon
country: United States
facility: Triwest Research Associates, LLC
state: California
city: Encino
country: United States
facility: T. Joseph Raoof MD, INC/Encino Research Center
state: California
city: Escondido
country: United States
facility: San Diego Imaging Escondido
state: California
city: Fair Oaks
country: United States
facility: Med Investigations, Inc.
state: California
city: Fresno
country: United States
facility: Research Center of Fresno, Inc.
state: California
city: Fresno
country: United States
facility: Neuro-Pain Medical Center
state: California
city: Garden Grove
country: United States
facility: Collaborative Neuroscience Network, LLC.
state: California
city: Gold River
country: United States
facility: Allied Clinical Research
state: California
city: Huntington Beach
country: United States
facility: HealthCare Partners Clinical Research, LLC.
state: California
city: Huntington Beach
country: United States
facility: Marvel Clinical Research LLC
state: California
city: La Mesa
country: United States
facility: BioSolutions Clinical Research Center
state: California
city: La Mesa
country: United States
facility: eStudySite
state: California
city: La Palma
country: United States
facility: Arthritis & Osteoporosis Medical Center
state: California
city: Lakewood
country: United States
facility: Center For United Research, Inc.
state: California
city: Long Beach
country: United States
facility: Collaborative Neuroscience Network, LLC.
state: California
city: Los Angeles
country: United States
facility: Aeon Research, Inc.
state: California
city: Los Angeles
country: United States
facility: American Institute of Research
state: California
city: Los Angeles
country: United States
facility: InterMed Medical Group
state: California
city: Los Angeles
country: United States
facility: IMD Medical Group
state: California
city: Montclair
country: United States
facility: Catalina Research Institute, LLC
state: California
city: North Hollywood
country: United States
facility: Providence Clinical Research
state: California
city: Northridge
country: United States
facility: Renaissance Imaging Medical Associates, Inc
state: California
city: Orange
country: United States
facility: NRC Research Institute
state: California
city: Palm Desert
country: United States
facility: Advances in Medicine
state: California
city: Riverside
country: United States
facility: Probe Clinical Research Corporation
state: California
city: Sacramento
country: United States
facility: University of California, Davis Health System
state: California
city: Sacramento
country: United States
facility: University of California, Davis Medical Center
state: California
city: Sacramento
country: United States
facility: Clinical Trials Research
state: California
city: Sacramento
country: United States
facility: Northern California Research
state: California
city: Sacramento
country: United States
facility: Center for Clinical Trials of Sacramento, Inc.
state: California
city: San Diego
country: United States
facility: Artemis Institute for Clinical Research
state: California
city: San Diego
country: United States
facility: San Diego Imaging, Kearny Mesa
state: California
city: San Diego
country: United States
facility: Sharp and Children's MRI Center, LLC
state: California
city: San Marcos
country: United States
facility: Artemis Institute for Clinical Research
state: California
city: Santa Ana
country: United States
facility: CITrials
state: California
city: Santa Ana
country: United States
facility: Syrentis Clinical Research
state: California
city: Thousand Oaks
country: United States
facility: Shariar Cohen, MD Corp.
state: California
city: Thousand Oaks
country: United States
facility: Westlake Medical Research
state: California
city: Valley Village
country: United States
facility: Bayview Research Group
state: California
city: Van Nuys
country: United States
facility: Renaissance Imaging Medical Associates, Inc
state: California
city: West Covina
country: United States
facility: Buhay & Maglunog MDS
state: California
city: West Hills
country: United States
facility: Prohealth Advanced Imaging
state: California
city: Westminster
country: United States
facility: Advanced Rx Clinical Research Group, Inc
state: California
city: Whittier
country: United States
facility: Medvin Clinical Research
state: California
city: Wildomar
country: United States
facility: Elite Clinical Trials
state: California
city: Denver
country: United States
facility: Mountain View Clinical Research, Inc.
state: Colorado
city: Denver
country: United States
facility: Mountain View Clinical Research, Inc
state: Colorado
city: Bridgeport
country: United States
facility: New England Research Associates, LLC
state: Connecticut
city: Danbury
country: United States
facility: Clinical Research Center of CT
state: Connecticut
city: Stamford
country: United States
facility: Stamford Therapeutics Consortium
state: Connecticut
city: Lewes
country: United States
facility: Delaware Arthritis
state: Delaware
city: Newark
country: United States
facility: Javed Rheumatology Associates, Inc.
state: Delaware
city: Atlantis
country: United States
facility: JEM Research Institute
state: Florida
city: Aventura
country: United States
facility: AARDS Research, Inc.
state: Florida
city: Boca Raton
country: United States
facility: RASF-Clinical Research, Inc
state: Florida
city: Boynton Beach
country: United States
facility: Orthopedic Research Institute
state: Florida
city: Brooksville
country: United States
facility: Meridien Research
state: Florida
city: Clearwater
country: United States
facility: Orthopaedic Associates of West Florida
state: Florida
city: Clearwater
country: United States
facility: Tampa Bay Medical Research, Inc
state: Florida
city: DeLand
country: United States
facility: Midland Florida Clinical Research Center, LLC
state: Florida
city: Fort Lauderdale
country: United States
facility: S&W Clinical Research
state: Florida
city: Fort Lauderdale
country: United States
facility: Centre for Rheumatology, Immunology and Arthritis
state: Florida
city: Fort Myers
country: United States
facility: Clinical Physiology Associates
state: Florida
city: Fort Myers
country: United States
facility: IMA
state: Florida
city: Gainesville
country: United States
facility: SIMEDHealth, LLC
state: Florida
city: Hialeah
country: United States
facility: South Florida Clinical Trials
state: Florida
city: Hollywood
country: United States
facility: Pines Clinical Research Inc.
state: Florida
city: Jacksonville
country: United States
facility: Jacksonville Center for Clinical Research
state: Florida
city: Jacksonville
country: United States
facility: Care Partners Clinical Research
state: Florida
city: Jacksonville
country: United States
facility: Clinical Neuroscience Solutions, Inc.
state: Florida
city: Miami
country: United States
facility: Columbus Clinical Services LLC
state: Florida
city: Miami
country: United States
facility: Pharmax Research Clinic, Inc.
state: Florida
city: Miami
country: United States
facility: Clintex Research Group
state: Florida
city: Miami
country: United States
facility: Center for Arthritis and Rheumatic Diseases
state: Florida
city: Miami
country: United States
facility: Larkin Imaging Center
state: Florida
city: Miami
country: United States
facility: New Horizon Research Center
state: Florida
city: Miami
country: United States
facility: International Research Associates, LLC
state: Florida
city: Miami
country: United States
facility: M&M Medical Center, Inc.
state: Florida
city: Miami
country: United States
facility: Quality Research & Medical Center LLC
state: Florida
city: Ocala
country: United States
facility: Renstar Medical Research
state: Florida
city: Ocala
country: United States
facility: American Family Medical
state: Florida
city: Ocoee
country: United States
facility: Sensible Healthcare, LLC.
state: Florida
city: Oldsmar
country: United States
facility: Journey Research, Inc.
state: Florida
city: Opa-locka
country: United States
facility: Sunshine Research Center
state: Florida
city: Orlando
country: United States
facility: Compass Research, LLC
state: Florida
city: Orlando
country: United States
facility: Rheumatology Associates of Central Florida, P.A.
state: Florida
city: Orlando
country: United States
facility: Omega Research Consultants, LLC
state: Florida
city: Oviedo
country: United States
facility: Oviedo Medical Research, LLC
state: Florida
city: Pensacola
country: United States
facility: Pensacola Research Consultants, Inc., d.b.a. Avanza Medical Research Center
state: Florida
city: Pensacola
country: United States
facility: Sacred Heart Orthopedics
state: Florida
city: Plantation
country: United States
facility: Orthopaedic Center of South Florida
state: Florida
city: Ponte Vedra
country: United States
facility: St. Johns Center for Clinical Research
state: Florida
city: Port Orange
country: United States
facility: Progressive Medical Research
state: Florida
city: Port Orange
country: United States
facility: Accord Clinical Research, LLC
state: Florida
city: Saint Petersburg
country: United States
facility: Meridien Research
state: Florida
city: Sarasota
country: United States
facility: Gulfcoast Research Institute, LLC
state: Florida
city: Sarasota
country: United States
facility: Kennedy White Orthopaedic Center
state: Florida
city: Sunrise
country: United States
facility: Precision Clinical Research, LLC.
state: Florida
city: Tamarac
country: United States
facility: Phoenix Clinical Research, LLC.
state: Florida
city: Tampa
country: United States
facility: Clinical Research of West Florida, Inc.
state: Florida
city: Tampa
country: United States
facility: Stedman Clinical Trials
state: Florida
city: Tampa
country: United States
facility: BayCare Medical Group, Inc
state: Florida
city: The Villages
country: United States
facility: Compass Research North LLC
state: Florida
city: West Palm Beach
country: United States
facility: Palm Beach Research Center
state: Florida
city: Atlanta
country: United States
facility: Atlanta Center for Medical Research
state: Georgia
city: Atlanta
country: United States
facility: Perimeter Institute for Clinical Research, Inc. DBA:/PICR Clinic
state: Georgia
city: Augusta
country: United States
facility: Masters of Clinical Research, Inc.
state: Georgia
city: Blue Ridge
country: United States
facility: River Birch Research Alliance, LLC
state: Georgia
city: Gainesville
country: United States
facility: Arthritis Center of North Georgia
state: Georgia
city: Gainesville
country: United States
facility: Center for Advanced Research & Education
state: Georgia
city: Marietta
country: United States
facility: Drug Studies America
state: Georgia
city: Newnan
country: United States
facility: Better Health Clinical Research, Inc.
state: Georgia
city: Stockbridge
country: United States
facility: Atlanta Orthopaedic Institute, LLC
state: Georgia
city: Suwanee
country: United States
facility: Herman Clinical Research, LLC
state: Georgia
city: Woodstock
country: United States
facility: North Georgia Clinical Research
state: Georgia
city: Woodstock
country: United States
facility: North Georgia Internal Medicine
state: Georgia
city: Honolulu
country: United States
facility: East-West Medical Research Institute
state: Hawaii
city: Boise
country: United States
facility: Idaho Sports Medicine Institute
state: Idaho
city: Boise
country: United States
facility: Injury Care Research, LLC
state: Idaho
city: Idaho Falls
country: United States
facility: Institute Of Arthritis Research
state: Idaho
city: Meridian
country: United States
facility: Advanced Clinical Research
state: Idaho
city: Chicago
country: United States
facility: Medex Healthcare Research, Inc.
state: Illinois
city: Chicago
country: United States
facility: Chicago Clinical Research Institute Inc.
state: Illinois
city: Chicago
country: United States
facility: Northwestern Memorial Hospital-Arkes Pavilion, Diagnostic Testing Center
state: Illinois
city: Chicago
country: United States
facility: Northwestern University Feinberg School of Medicine
state: Illinois
city: Chicago
country: United States
facility: Rush University Medical Center
state: Illinois
city: Chicago
country: United States
facility: Great Lakes Clinical Trials
state: Illinois
city: Oak Lawn
country: United States
facility: Affinity Clinical Research Institute
state: Illinois
city: Oak Lawn
country: United States
facility: Southwest Center for Healthy Joints, S.C.
state: Illinois
city: Peoria
country: United States
facility: Methodist Research Administration Office
state: Illinois
city: Peoria
country: United States
facility: UnityPoint Clinic Rheumatology
state: Illinois
city: Peoria
country: United States
facility: Methodist Medical Center of Illinois
state: Illinois
city: Rockford
country: United States
facility: OrthoIllinois
state: Illinois
city: Rockford
country: United States
facility: Quest Diagnostics
state: Illinois
city: Evansville
country: United States
facility: MediSphere Medical Research Center, LLC
state: Indiana
city: Valparaiso
country: United States
facility: Buynak Clinical Research, P.C.
state: Indiana
city: Overland Park
country: United States
facility: Mid-America Physiatrists, P.A.
state: Kansas
city: Prairie Village
country: United States
facility: Phoenix Medical Research, Inc.
state: Kansas
city: Wichita
country: United States
facility: Professional Research Network of Kansas, LLC
state: Kansas
city: Wichita
country: United States
facility: Heartland Research Associates, LLC
state: Kansas
city: Edgewood
country: United States
facility: Otrimed Corporation
state: Kentucky
city: Lexington
country: United States
facility: Central Kentucky Research Associates, Inc.
state: Kentucky
city: Baton Rouge
country: United States
facility: Baton Rouge General Medical Center-Internal Medicine Clinic
state: Louisiana
city: Baton Rouge
country: United States
facility: Baton Rouge General Medical Center-Midcity
state: Louisiana
city: Baton Rouge
country: United States
facility: Baton Rouge General Medical Center-Bluebonnet
state: Louisiana
city: Baton Rouge
country: United States
facility: Baton Rouge General Medical Center-Clinical Trials Office
state: Louisiana
city: Lake Charles
country: United States
facility: Centex Studies, Inc.
state: Louisiana
city: Cumberland
country: United States
facility: Klein & Associates, M.D., P.A.
state: Maryland
city: Frederick
country: United States
facility: Arthritis Treatment Center
state: Maryland
city: Hagerstown
country: United States
facility: Klein & Associates, M.D., P.A.
state: Maryland
city: Wheaton
country: United States
facility: The Center for Rheumatology and Bone Research
state: Maryland
city: Quincy
country: United States
facility: Beacon Clinical Research, LLC
state: Massachusetts
city: Watertown
country: United States
facility: MedVadis Research Corporation
state: Massachusetts
city: Bay City
country: United States
facility: Great Lakes Research Group, Incorporated
state: Michigan
city: Caro
country: United States
facility: Onyx Clinical Research
state: Michigan
city: Grand Rapids
country: United States
facility: Orthopaedic Associates of Michigan, PC
state: Michigan
city: Lansing
country: United States
facility: June D.O. PC
state: Michigan
city: Pinconning
country: United States
facility: Great Lakes Research Group
state: Michigan
city: Rochester Hills
country: United States
facility: Michigan Orthopaedic Spine Surgeons
state: Michigan
city: Traverse City
country: United States
facility: Medical Research Associates Inc.
state: Michigan
city: Troy
country: United States
facility: Oakland Medical Research Center
state: Michigan
city: Olive Branch
country: United States
facility: Olive Branch Family Medical Center
state: Mississippi
city: Southaven
country: United States
facility: Landmark Internal Medicine
state: Mississippi
city: Columbia
country: United States
facility: University of Missouri Health Care-Investigational Pharmacy
state: Missouri
city: Columbia
country: United States
facility: University of Missouri Health Care
state: Missouri
city: Columbia
country: United States
facility: University of Missouri School of Medicine- Clinical Research Center
state: Missouri
city: Saint Louis
country: United States
facility: Advance Clinical Research, Inc.
state: Missouri
city: Saint Louis
country: United States
facility: Medex Healthcare Research, Inc.
state: Missouri
city: Lincoln
country: United States
facility: Physician Research Collaboration, LLC
state: Nebraska
city: Las Vegas
country: United States
facility: Affiliated Clinical Research, Inc.
state: Nevada
city: Las Vegas
country: United States
facility: Impact Clinical Trials
state: Nevada
city: Las Vegas
country: United States
facility: Office of Stephen H. Miller, MD
state: Nevada
city: Las Vegas
country: United States
facility: Clinical Research Consortium
state: Nevada
city: Las Vegas
country: United States
facility: Office of Robert P. Kaplan, DO
state: Nevada
city: Las Vegas
country: United States
facility: Advanced Biomedical Research of America
state: Nevada
city: Las Vegas
country: United States
facility: G. Timothy Kelly, MD
state: Nevada
city: Portsmouth
country: United States
facility: ActivMed Practices & Research, Inc.
state: New Hampshire
city: Toms River
country: United States
facility: Ocean Rheumatology, PA
state: New Jersey
city: Trenton
country: United States
facility: Premier Research
state: New Jersey
city: Voorhees
country: United States
facility: Arthritis, Rheumatic and Back Disease Associates, PA
state: New Jersey
city: Albuquerque
country: United States
facility: Albuquerque Clinical Trials, Inc.
state: New Mexico
city: Albuquerque
country: United States
facility: New Mexico Clinical Research & Osteoporosis Center, Inc.
state: New Mexico
city: Albuquerque
country: United States
facility: Lovelace Scientific Resources Inc.
state: New Mexico
city: Brooklyn
country: United States
facility: NYU Langone Ambulatory Care Brooklyn Heights
state: New York
city: Brooklyn
country: United States
facility: Drug Trials Brooklyn
state: New York
city: Brooklyn
country: United States
facility: SPRI Clinical Trials, LLC
state: New York
city: Hartsdale
country: United States
facility: Drug Trials America
state: New York
city: Lake Success
country: United States
facility: NYU Langone Arena Oncology, Laura and Issac Perlmutter Cancer Center, Infusion Center
state: New York
city: Lake Success
country: United States
facility: NYU Langone Arena Oncology, Laura and Issac Perlmutter Cancer Center
state: New York
city: Lake Success
country: United States
facility: NYU Langone Rheumatology Associates Long Island
state: New York
city: New York
country: United States
facility: Lenox Hill Radiology
state: New York
city: New York
country: United States
facility: Manhattan Medical Research Practice PLLC
state: New York
city: New York
country: United States
facility: The Medical Research Network, LLC
state: New York
city: Rochester
country: United States
facility: AAIR Research Center
state: New York
city: Williamsville
country: United States
facility: Upstate Clinical Research Associates, LLC
state: New York
city: Lenoir
country: United States
facility: Northstate Clinical Research, PLLC
state: North Carolina
city: Raleigh
country: United States
facility: Wake Internal Medicine Consultants, Inc
state: North Carolina
city: Raleigh
country: United States
facility: Wake Research Associates, LLC
state: North Carolina
city: Winston-Salem
country: United States
facility: The Center for Clinical Research
state: North Carolina
city: Fargo
country: United States
facility: Lillestol Research, LLC
state: North Dakota
city: Fargo
country: United States
facility: Plains Clinical Research Center, LLC
state: North Dakota
city: Centerville
country: United States
facility: Valley Medical Research/Valley Medical Primary Care
state: Ohio
city: Cincinnati
country: United States
facility: Hightop Medical Research Center
state: Ohio
city: Cincinnati
country: United States
facility: New Horizons Clinical Research
state: Ohio
city: Cincinnati
country: United States
facility: CTI Clinical Research Center
state: Ohio
city: Columbus
country: United States
facility: Aventiv Research Inc.
state: Ohio
city: Columbus
country: United States
facility: Remington-Davis, Incorporated
state: Ohio
city: Columbus
country: United States
facility: Optimed Research LTD
state: Ohio
city: Dayton
country: United States
facility: Dayton Clinical Research
state: Ohio
city: Dayton
country: United States
facility: PriMed Clinical Research
state: Ohio
city: Kettering
country: United States
facility: Kettering Medical Center
state: Ohio
city: Springboro
country: United States
facility: Springboro Health Center
state: Ohio
city: Tiffin
country: United States
facility: AC Clinical Research
state: Ohio
city: Toledo
country: United States
facility: Glendale Medical Center
state: Ohio
city: Toledo
country: United States
facility: Bone Joint & Spine Surgeons, Inc.
state: Ohio
city: Oklahoma City
country: United States
facility: Health Research of Oklahoma
state: Oklahoma
city: Oklahoma City
country: United States
facility: Lynn Health Science Institute
state: Oklahoma
city: Altoona
country: United States
facility: University Orthopedics Center
state: Pennsylvania
city: Beaver
country: United States
facility: Heritage Valley Medical Group, Inc.
state: Pennsylvania
city: Downingtown
country: United States
facility: Brandywine Clinical Research
state: Pennsylvania
city: Duncansville
country: United States
facility: Altoona Center for Clinical Research
state: Pennsylvania
city: Jenkintown
country: United States
facility: The Clinical Trial Center LLC
state: Pennsylvania
city: Philadelphia
country: United States
facility: Founders Research Corporation
state: Pennsylvania
city: Philadelphia
country: United States
facility: The Arthritis Group
state: Pennsylvania
city: Wyomissing
country: United States
facility: Clinical Research Center of Reading, LLC
state: Pennsylvania
city: Little River
country: United States
facility: Main Street Physician's Care - Waterway
state: South Carolina
city: Loris
country: United States
facility: Main Street Physician's Care - Loris
state: South Carolina
city: North Myrtle Beach
country: United States
facility: North Myrtle Beach Family Practice
state: South Carolina
city: Jackson
country: United States
facility: Clinical Research Solutions
state: Tennessee
city: Jackson
country: United States
facility: Physicians Quality Care
state: Tennessee
city: Jefferson City
country: United States
facility: PMG Research, Inc. d/b/a PMG Research of Knoxville
state: Tennessee
city: Knoxville
country: United States
facility: PCET Research Center, LLC
state: Tennessee
city: Memphis
country: United States
facility: Diagnostic Imaging PC
state: Tennessee
city: Austin
country: United States
facility: ARC Clinical Research at Wilson Parke
state: Texas
city: Austin
country: United States
facility: Tekton Research, Inc.
state: Texas
city: Baytown
country: United States
facility: Urgent Care MD's
state: Texas
city: Bedford
country: United States
facility: Texas Orthopedic Specialists, PLLC
state: Texas
city: Dallas
country: United States
facility: Galenos Research
state: Texas
city: Houston
country: United States
facility: Abigail R. Neiman, MD, PA
state: Texas
city: Houston
country: United States
facility: Advances in Health
state: Texas
city: Houston
country: United States
facility: Mercury Clinical Research, Inc.
state: Texas
city: Houston
country: United States
facility: Centex Studies, Inc.
state: Texas
city: Houston
country: United States
facility: Memorial Pulmonology
state: Texas
city: Houston
country: United States
facility: BI Research Center
state: Texas
city: Plano
country: United States
facility: Clinical Investigations of Texas
state: Texas
city: Richardson
country: United States
facility: ClinRX Research
state: Texas
city: San Antonio
country: United States
facility: Quality Research, Inc.
state: Texas
city: San Antonio
country: United States
facility: Lee Medical Associates PA
state: Texas
city: San Antonio
country: United States
facility: Progressive Clinical Research, PA
state: Texas
city: San Antonio
country: United States
facility: Sun Research Institute
state: Texas
city: San Antonio
country: United States
facility: Panacea Clinical Research
state: Texas
city: San Antonio
country: United States
facility: Accurate Clinical Research Inc.
state: Texas
city: San Antonio
country: United States
facility: Diagnostics Research Group
state: Texas
city: San Antonio
country: United States
facility: Victorium Clinical Research
state: Texas
city: San Antonio
country: United States
facility: DCT-Stone Oak, LLC dba Discovery Clinical Trials
state: Texas
city: San Antonio
country: United States
facility: South Texas Radiology Imaging Centers
state: Texas
city: Southlake
country: United States
facility: Envision Imaging
state: Texas
city: Sugar Land
country: United States
facility: Oakbend Medical Center
state: Texas
city: Waxahachie
country: United States
facility: ClinPoint Trials
state: Texas
city: Webester
country: United States
facility: Mercury Clinical Research
state: Texas
city: Wichita Falls
country: United States
facility: Clinics of North Texas
state: Texas
city: Wichita Falls
country: United States
facility: Grayline Clinical Drug Trials
state: Texas
city: Riverton
country: United States
facility: Granger Medical Clinic-Riverton
state: Utah
city: Arlington
country: United States
facility: Millennium Clinical Trials, LLC
state: Virginia
city: Charlottesville
country: United States
facility: Charlottesville Medical Research Center, LLC
state: Virginia
city: Fairfax
country: United States
facility: Millennium Clinical Trials
state: Virginia
city: Norfolk
country: United States
facility: National Clinical Research-Norfolk, Inc.
state: Virginia
city: Bellevue
country: United States
facility: Northwest Clinical Research Center
state: Washington
city: Bellingham
country: United States
facility: Optimed Research, LTD
state: Washington
city: Seattle
country: United States
facility: Swedish Medical Center Investigational Drug Services Pharmacy
state: Washington
city: Seattle
country: United States
facility: Seattle Rheumatology Associates
state: Washington
city: Seattle
country: United States
facility: Swedish Medical Center
state: Washington
city: Broadmeadow
country: Australia
facility: Genesis Research Services
state: New South Wales
city: Cardiff
country: Australia
facility: Hunter Imaging Group
state: New South Wales
city: Kogarah
country: Australia
facility: Optimus Clinical Research Pty Ltd
state: New South Wales
city: Miranda
country: Australia
facility: Southern Radiology
state: New South Wales
city: Randwick
country: Australia
facility: Royal Hospital for Women
state: New South Wales
city: St Leonards
country: Australia
facility: Castlereagh Imaging
state: New South Wales
city: St Leonards
country: Australia
facility: Royal North Shore Hospital
state: New South Wales
city: Sydney
country: Australia
facility: Australian Clinical Research Network
state: New South Wales
city: Sydney
country: Australia
facility: Spectrum Medical Imaging
state: New South Wales
city: Sherwood
country: Australia
facility: AusTrials Pty Ltd
state: Queensland
city: Adelaide
country: Australia
facility: CMAX Clinical Research Pty Ltd
state: South Australia
city: Adelaide
country: Australia
facility: Royal Adelaide Hospital Pharmacy
state: South Australia
city: North Adelaide
country: Australia
facility: Bensons Radiology
state: South Australia
city: Camberwell
country: Australia
facility: Emeritus Research
state: Victoria
city: Melbourne
country: Australia
facility: Capital Radiology-Malvern
state: Victoria
city: Melbourne
country: Australia
facility: Capital Radiology-Clayton
state: Victoria
city: Nedlands
country: Australia
facility: SKG Radiology Hollywood
state: Western Australia
city: Victoria Park
country: Australia
facility: RK Will Pty Ltd
state: Western Australia
city: Juiz de Fora
country: Brazil
facility: CMIP-Centro Mineiro de Pesquisa LTDA
state: Minas Gerais
city: Rio De Janeiro
country: Brazil
facility: CCBR - Centro de Pesquisas e Analises Clinicas LTDA
state: RJ
city: Sao Paulo
country: Brazil
facility: CEPIC - Centro Paulista de Investigacao Clinica e Servicos Medicos Ltda
state: SP
city: Plovdiv
country: Bulgaria
facility: Diagnostic Consultative Center "Sveti Georgi" EOOD
city: Plovdiv
country: Bulgaria
facility: Medical Center "Health for all" - EOOD
city: Plovdiv
country: Bulgaria
facility: UMHAT Kaspela - EOOD Rheumatology Clinic
city: Plovdiv
country: Bulgaria
facility: UMHAT Kaspela - EOOD
city: Ruse
country: Bulgaria
facility: "Medical Center Teodora" EOOD
city: Sofia
country: Bulgaria
facility: Diagnostic Consultative Center 17 Sofia EOOD
city: Sofia
country: Bulgaria
facility: UMHAT Sveti Ivan Rilski- EAD
city: Sofia
country: Bulgaria
facility: UMHAT "Sofiamed" OOD, Block 2
city: Sofia
country: Bulgaria
facility: "Medical Center- Dr. Hayvazov" EOOD
city: Medellin
country: Colombia
facility: Centro Integral de Reumatologia Reumalab S.A.S.
state: Antioquia
city: Bogota
country: Colombia
facility: Centro de Investigacion en Reumatologia y Especialidades Medicas SAS CIREEM SAS
state: Bogota DC
city: Zagreb
country: Croatia
facility: Medicinski centar Kuna&Peric
city: Toyohashi
country: Japan
facility: National Hospital Organization Toyohashi Medical Center
state: Aichi
city: Funabashi
country: Japan
facility: Funabashi Municipal Medical Center
state: Chiba
city: Matsudo
country: Japan
facility: Matsudo City General Hospital
state: Chiba
city: Kitakyushu
country: Japan
facility: Kanbara Clinic
state: Fukuoka
city: Kurume
country: Japan
facility: Hidaka Orthopedic Hospital
state: Fukuoka
city: Miyako-gun
country: Japan
facility: Obase Hospital
state: Fukuoka
city: Yamegun
country: Japan
facility: Himeno Hospital
state: Fukuoka
city: Sukagawa
country: Japan
facility: Ikeda Kinen Hospital
state: Fukushima
city: Maebashi
country: Japan
facility: Zenshukai Hospital
state: Gunma
city: Aki-gun
country: Japan
facility: Mazda Hospital
state: Hiroshima
city: Kure
country: Japan
facility: Medical Corporation Okimoto Clinic
state: Hiroshima
city: Kure
country: Japan
facility: Medical Corporation Emu Emukai, Matterhorn Rehabilitation Hospital
state: Hiroshima
city: Chitose
country: Japan
facility: Takahashi Orthopedics Clinic
state: Hokkaido
city: Obihiro
country: Japan
facility: Obihiro Orthopaedic Hospital
state: Hokkaido
city: Akashi
country: Japan
facility: Okubo Hospital
state: Hyogo
city: Himeji
country: Japan
facility: Omuro Orthopedic Clinic
state: Hyogo
city: Kako-gun
country: Japan
facility: Medical corporate corporation hoshikai Onishi medical clinic
state: Hyogo
city: Kobe
country: Japan
facility: Kobe Red Cross Hospital
state: Hyogo
city: Mito
country: Japan
facility: Mito Saiseikai General Hospital
state: Ibaraki
city: Kanazawa
country: Japan
facility: National Hospital Organization Kanazawa Medical Center
state: Ishikawa
city: Kawasaki
country: Japan
facility: Kokan Clinic
state: Kanagawa
city: Yawata
country: Japan
facility: Misugikai Medical Corporation Otokoyama Hospital
state: Kyoto
city: Sendai
country: Japan
facility: Nakajo Orthopedic Clinic
state: Miyagi
city: Matsumoto
country: Japan
facility: Marunouchi Hospital
state: Nagano
city: Yufu
country: Japan
facility: Oita University Hospital
state: Oita
city: Higashiosaka
country: Japan
facility: Sobajima Clinic/Orthopedics
state: Osaka
city: Izumisano
country: Japan
facility: Rinku General Medical Center
state: Osaka
city: Kishiwada
country: Japan
facility: Kishiwada Tokushukai Hospital
state: Osaka
city: Osaka-shi
country: Japan
facility: Social Welfare Organization Saiseikai Imperial Gift Foundation,Inc. Osaka Saiseikai Nakatsu Hospital
state: Osaka
city: Suita
country: Japan
facility: Osaka University Hospital
state: Osaka
city: Izumo
country: Japan
facility: Shimane University Hospital
state: Shimane
city: Fujieda
country: Japan
facility: Fujieda Municipal General Hospital
state: Shizuoka
city: Hamamatsu
country: Japan
facility: JA Shizuoka Kohseiren Enshu Hospital
state: Shizuoka
city: Hamamatsu
country: Japan
facility: Japanese Red Cross Hamamatsu Hospital
state: Shizuoka
city: Adachi-ku
country: Japan
facility: Sonodakai Joint Replacement Center Hospital
state: Tokyo
city: Edogawa-ku
country: Japan
facility: Medical Plaza Edogawa
state: Tokyo
city: Edogawa-ku
country: Japan
facility: Sato Orthopaedic Clinic
state: Tokyo
city: Fussa
country: Japan
facility: Fussa Hospital
state: Tokyo
city: Koto-ku
country: Japan
facility: Jukoukai hospital
state: Tokyo
city: Minato-ku
country: Japan
facility: Kitasato University Kitasato Institute Hospital
state: Tokyo
city: Setagaya-ku
country: Japan
facility: Tamagawa Hospital
state: Tokyo
city: Shinagawa-ku
country: Japan
facility: Kohno Clinical Medicine Research Institute Daisan Kitashinagawa Hospital
state: Tokyo
city: Shinagawa-ku
country: Japan
facility: Ohimachi Orthopaedic Clinic
state: Tokyo
city: Yonago
country: Japan
facility: Japan Organization of Occupational Health and Safety Sanin Rosai Hospital
state: Tottori
city: Chiba
country: Japan
facility: National Hospital Organization Chiba Medical Center
city: Fukuoka
country: Japan
facility: Chihaya Hospital
city: Fukuoka
country: Japan
facility: Kuroda Orthopedic Hospital
city: Hiroshima
country: Japan
facility: Hiroshima Red Cross Hospital & Atomic-bomb Survivors Hospital
city: Hiroshima
country: Japan
facility: Hiroshima Prefectural Hospital
city: Kumamoto
country: Japan
facility: Kumamoto Orthopaedic Hospital
city: Osaka
country: Japan
facility: Nagayoshi General Hospital
city: Saitama
country: Japan
facility: Iwasaki Orthopedic Surgery
city: Saitama
country: Japan
facility: Saitama Municipal Hospital
city: Daegu
country: Korea, Republic of
facility: Daegu Catholic University Medical Center
city: Daegu
country: Korea, Republic of
facility: Department of Radiology
city: Daegu
country: Korea, Republic of
facility: Division of Rheumatology, Department of Internal Medicine, Daegu Catholic University Medical Center
city: Daejeon
country: Korea, Republic of
facility: Chungnam National University Hospital
city: Daejeon
country: Korea, Republic of
facility: Clinical Trial Center Pharmacy
city: Daejeon
country: Korea, Republic of
facility: Department of Radiology
city: Gwangju
country: Korea, Republic of
facility: Chonnam National University Hospital
city: Gwangju
country: Korea, Republic of
facility: Department of Radiology
city: Gwangju
country: Korea, Republic of
facility: Pharmacy of Clinical Trial Center
city: Seoul
country: Korea, Republic of
facility: Clinical Trial Pharmacy
city: Seoul
country: Korea, Republic of
facility: Department of Radiology
city: Seoul
country: Korea, Republic of
facility: Korea University Anam Hospital
city: Seoul
country: Korea, Republic of
facility: Clinical Trials Center Pharmacy
city: Seoul
country: Korea, Republic of
facility: Seoul National University Hospital
city: Seoul
country: Korea, Republic of
facility: Clinical Trial Center Pharmacy
city: Seoul
country: Korea, Republic of
facility: Department of Radiology
city: Seoul
country: Korea, Republic of
facility: Yonsei University Health System, Severance Hospital
city: Seoul
country: Korea, Republic of
facility: Clinical Research Pharmacy
city: Seoul
country: Korea, Republic of
facility: Department of Clinical Research Pharmacy, Konkuk University Medical Center
city: Seoul
country: Korea, Republic of
facility: Department of Radiology
city: Seoul
country: Korea, Republic of
facility: Division of Rheumatology, Department of Internal Medicine, Konkuk University Medical Center
city: Seoul
country: Korea, Republic of
facility: Konkuk University Medical Center
city: Seoul
country: Korea, Republic of
facility: Clinical Trial Center Pharmacy
city: Seoul
country: Korea, Republic of
facility: Department of Orthopedic Surgery, Samsung Medical Center
city: Seoul
country: Korea, Republic of
facility: Clinical Trial Pharmacy
city: Seoul
country: Korea, Republic of
facility: Department of Radiology
city: Seoul
country: Korea, Republic of
facility: The Catholic University of Korea Seoul St. Mary's Hospital
city: Seoul
country: Korea, Republic of
facility: Clinical Research Pharmacy, SMG SNU Boramae Medical Center
city: Seoul
country: Korea, Republic of
facility: Department of Clinical Research Pharmacy, SMG-SNU Boramae Medical Center
city: Seoul
country: Korea, Republic of
facility: Department of Radiology
city: Seoul
country: Korea, Republic of
facility: SMG-SNU Boramae Medical Center
city: Seoul
country: Korea, Republic of
facility: Department of Radiology
city: Seoul
country: Korea, Republic of
facility: Ewha Womans University Mokdong Hospital
city: Yangcheon-gu, Seoul
country: Korea, Republic of
facility: Clinical Trial Pharmacy
city: Kaunas
country: Lithuania
facility: Saules seimos medicinos centras
city: Klaipeda
country: Lithuania
facility: Klaipeda University Hospital
city: Siauliai
country: Lithuania
facility: Republican Siauliai Hospital
city: Guadajara
country: Mexico
facility: Centro Hospitalario Mac, S.A. de C.V.
state: Jalisco
city: Guadalajara
country: Mexico
facility: Consultorio Medico del Dr. Federico Galvan Villegas
state: Jalisco
city: Rotorua
country: New Zealand
facility: Lakeland Clinical Trials
state: BOP
city: Dunedin
country: New Zealand
facility: Otago Radiology
state: Otago
city: Dunedin
country: New Zealand
facility: RMC Medical Research Ltd
state: Otago
city: Auckland
country: New Zealand
facility: South Pacific Clinical Trials
city: Auckland
country: New Zealand
facility: TRG Imaging Lincoln Road
city: Auckland
country: New Zealand
facility: Auckland Bone Density Ltd
city: Auckland
country: New Zealand
facility: North Shore Hospital, Waitemata District Health Board
city: Auckland
country: New Zealand
facility: Star Unit, North Shore Hospital, Waitemata District Health Board
city: Auckland
country: New Zealand
facility: The Radiology Group
city: Auckland
country: New Zealand
facility: Southern Clinical Trials- Waitemata Ltd
city: Auckland
country: New Zealand
facility: Auckland Bone Density
city: Auckland
country: New Zealand
facility: Optimal Clinical Trials
city: Auckland
country: New Zealand
facility: Auckland Radiology Parnell Branch
city: Christchurch
country: New Zealand
facility: Southern Clinical Trials Ltd
city: Nelson
country: New Zealand
facility: Collingwood Street Pharmacy
city: Nelson
country: New Zealand
facility: Nelson Radiology
city: Nelson
country: New Zealand
facility: Porter Rheumatology Ltd
city: Tauranga
country: New Zealand
facility: Bay Radiology
city: Tauranga
country: New Zealand
facility: P3 Research Ltd
city: Tauranga
country: New Zealand
facility: Clinical Horizons NZ Ltd
city: Wellington
country: New Zealand
facility: P3 Research Ltd
city: Wellington
country: New Zealand
facility: Pacific Radiology
city: Cayma
country: Peru
facility: Unidad de Investigacion en Medicina Interna y Enfermedades criticas-Hogar Clinica San Juan de Dios
state: Arequipa
city: Trujillo
country: Peru
facility: Centro De Investigacion Clinica Trujillo EIRL/Clinica Peruano Americana S.A.
state: LA Libertad
city: Lima
country: Peru
facility: ABK REUMA S.R.L. de Medicentro Biociencias/BIO CIENCIAS PERU S.R.L.
city: Lima
country: Peru
facility: Centro de Investigación Reumatología CAA-Clinica Anglo Americana
city: Lima
country: Peru
facility: Investigaciones en Reumatologia / Centro Medico Corpac S.A.
city: Lima
country: Peru
facility: Centro de Investigaciones Medicas-Hospital Maria Auxiliadora
city: Lima
country: Peru
facility: Investigaciones Clinicas S.A.C. / Instituto de Ginecologia y Reproduccion S.A.
city: Lima
country: Peru
facility: Investigaciones Clinicas S.A.C./Instituto de Ginecologia y Reproduccion S.A.
city: Manila
country: Philippines
facility: Philippine General Hospital
state: NCR
city: Manila
country: Philippines
facility: Manila Doctors Hospital
city: Moscow
country: Russian Federation
facility: Moscow Municipal Rheumatology Center
city: Moscow
country: Russian Federation
facility: SBHI "City Clinical Hospital No. 1 n.a N.I. Pirogov"
city: Moscow
country: Russian Federation
facility: SBHI "City Clinical Hospital No. 1 n.a. N.I. Pirogov"
city: Novosibirsk
country: Russian Federation
facility: Federal State Budgetary Scientific Research institution of fundamental and clinical immunology
city: Novosibirsk
country: Russian Federation
facility: Federal State Budgetary Scientific Institution
city: Ryazan
country: Russian Federation
facility: State Budgetary Institution of Ryazan Region
city: Saint Petersburg
country: Russian Federation
facility: Medical Technologies Ltd
city: Saint Petersburg
country: Russian Federation
facility: Limited Liability Company "Medical Center "Reavita Med SPb"
city: Saint Petersburg
country: Russian Federation
facility: Medinet LLC
city: Saint Petersburg
country: Russian Federation
facility: FSBI 'SRITO n.a. R.R. Vreden' MoH RF
city: Belgrade
country: Serbia
facility: Institute for Rehabilitation
city: Belgrade
country: Serbia
facility: Institute of Rheumatology
city: Niska Banja
country: Serbia
facility: Institute for treatment and rehabilitation "Niska Banja"
city: Novi Sad
country: Serbia
facility: Special Hospital for Rheumatic Diseases Novi Sad
city: Sabac
country: Serbia
facility: General hospital "Dr Laza K. Lazarevic" Sabac
city: Bratislava
country: Slovakia
facility: Reumatologia s.r.o.
city: Bratislava
country: Slovakia
facility: Nestatna Reumatologicka Ambulancia, Poliklinika Karlova Ves
city: Kosice
country: Slovakia
facility: MUDr. STRANAI s.r.o.
city: Nove Mesto nad Vahom
country: Slovakia
facility: Reum.hapi s.r.o.
city: Piestany
country: Slovakia
facility: MEDIPA s.r.o.
city: Piestany
country: Slovakia
facility: Thermium s.r.o.
city: Changhua
country: Taiwan
facility: Changhua Christian Hospital Clinical Trial Pharmacy
city: Changhua
country: Taiwan
facility: Changhua Christian Hospital
city: Kaohsiung
country: Taiwan
facility: Chang Gung Memorial Hospital-Kaohsiung Branch Clinical Trial Pharmacy
city: Kaohsiung
country: Taiwan
facility: Chang Gung Memorial Hospital-Kaohsiung Branch
city: Taichung
country: Taiwan
facility: Chung Shan Medical University Hospital Clinical Trial Pharmacy
city: Taichung
country: Taiwan
facility: Chung Shan Medical University Hospital
city: Taichung
country: Taiwan
facility: China Medical University Hospital
city: Taichung
country: Taiwan
facility: Department of Pharmacy, China Medical University Hospital
city: Chernivtsi
country: Ukraine
facility: Regional Communal Institution Chernivtsi Regional Clinical Hospital
city: Kharkiv
country: Ukraine
facility: Communal Non-profit Institution "City Clinical Hospital No.27" of Kharkiv City Council
city: Kharkiv
country: Ukraine
facility: Government Institution "L.T. Malaya Therapy National Institute of the NAMS of Ukraine"
city: Kyiv
country: Ukraine
facility: Chair of Internal Medicine #2
city: Kyiv
country: Ukraine
facility: Oleksandrivska Clinical Hospital Of Kyiv
city: Kyiv
country: Ukraine
facility: Kyiv City Clinical Hospital 3,Rheumatology Department
city: Kyiv
country: Ukraine
facility: Clinic of NI "NSC"M.D.Strazhesko Institute of Cardiology" of NAMS of Ukraine,
city: Kyiv
country: Ukraine
facility: Polyclinic of Administration of Medical Services and Rehabilitation of State Stock Holding Company
city: Kyiv
country: Ukraine
facility: Clinic of SI "Institute of Gerontology named after D.F Chebotarov of NAMS of Ukraine"
city: Kyiv
country: Ukraine
facility: Clinic of SI Institute of Gerontology named after D.F Chebotarov of NAMS of Ukraine
city: Kyiv
country: Ukraine
facility: National Medical University named after O O Bogomolets,
city: Kyiv
country: Ukraine
facility: Polyclinic Of Administration of Medical Services and Rehabilitation of SSHC Artem
city: Lviv
country: Ukraine
facility: Communal Non-profit Institution "City Clinical Hospital #5 of Lviv", Therapeutics Department
city: Odesa
country: Ukraine
facility: Communal Institution "Odesa Regional Clinical Hospital"
city: Odesa
country: Ukraine
facility: Multi-field Medical Center (University Clinic No.1) of Odesa National Medical University,
city: Ternopil
country: Ukraine
facility: Communal Institution Ternopil University Hospital
city: Vinnytsia
country: Ukraine
facility: Vinnytsia Regional Clinical Hospital named after M.I. Pyrogov, Rheumatology Department,
city: Vinnytsia
country: Ukraine
facility: Communal Non-commercial Enterprise "Vinnytsia City Clinical Hospital No 1"
city: Vinnytsia
country: Ukraine
facility: Medical Clinical Investigational Centre of Medical Centre Health Clinic LTD
city: Vinnytsia
country: Ukraine
facility: Scientific and Research Institute of Invalid Rehabilitation (Educational and Scientific Medical
city: Vinnytsia
country: Ukraine
facility: Vinnytsya Medical National University named after M.I. Pyrogov, Chair of Internal Medicine #3
city: Zaporizhzhya
country: Ukraine
facility: Communal Institution Zaporizhzhya Regional Clinical Hospital
Study officials:
affiliation: Pfizer
name: Pfizer CT.gov Call Center
role: STUDY_DIRECTOR
References:
citation: Atkinson J, Edwards RA, Bonfanti G, Barroso J, Schnitzer TJ. A Two-Step, Trajectory-Focused, Analytics Approach to Attempt Prediction of Analgesic Response in Patients with Moderate-to-Severe Osteoarthritis. Adv Ther. 2023 Jan;40(1):252-264. doi: 10.1007/s12325-022-02336-6. Epub 2022 Oct 27.
citation: Mease P, Kuritzky L, Wright WL, Mallick-Searle T, Fountaine R, Yang R, Sadrarhami M, Faison W, Johnston E, Viktrup L. Efficacy and safety of tanezumab, NSAIDs, and placebo in patients with moderate to severe hip or knee osteoarthritis and a history of depression, anxiety, or insomnia: post-hoc analysis of phase 3 trials. Curr Med Res Opin. 2022 Nov;38(11):1909-1922. doi: 10.1080/03007995.2022.2113689. Epub 2022 Aug 28.
citation: Schnitzer TJ, Bonfanti G, Atkinson J, Donevan S, Viktrup L, Barroso J, Whalen E, Edwards RA. Characterizing 16-Week Responder Profiles Using Group-Based Trajectory Modeling in Over 4300 Clinical Trial Participants Receiving Pharmaceutical Treatment for Moderate to Severe Osteoarthritis. Adv Ther. 2022 Oct;39(10):4742-4756. doi: 10.1007/s12325-022-02290-3. Epub 2022 Aug 12.
citation: Neogi T, Hunter DJ, Churchill M, Shirinsky I, White A, Guermazi A, Omata M, Fountaine RJ, Pixton G, Viktrup L, Brown MT, West CR, Verburg KM. Observed efficacy and clinically important improvements in participants with osteoarthritis treated with subcutaneous tanezumab: results from a 56-week randomized NSAID-controlled study. Arthritis Res Ther. 2022 Mar 29;24(1):78. doi: 10.1186/s13075-022-02759-0.
citation: Conaghan PG, Dworkin RH, Schnitzer TJ, Berenbaum F, Bushmakin AG, Cappelleri JC, Viktrup L, Abraham L. WOMAC Meaningful Within-patient Change: Results From 3 Studies of Tanezumab in Patients With Moderate-to-severe Osteoarthritis of the Hip or Knee. J Rheumatol. 2022 Jun;49(6):615-621. doi: 10.3899/jrheum.210543. Epub 2022 Mar 1.
citation: Brown MT, Sandroni P, Low PA, Gorson KC, Hunter DJ, Pixton GC, Fountaine RJ, Viktrup L, West CR, Verburg KM. Neurological safety of subcutaneous tanezumab versus NSAID in patients with osteoarthritis. J Neurol Sci. 2022 Mar 15;434:120184. doi: 10.1016/j.jns.2022.120184. Epub 2022 Feb 14.
citation: Hochberg MC, Carrino JA, Schnitzer TJ, Guermazi A, Walsh DA, White A, Nakajo S, Fountaine RJ, Hickman A, Pixton G, Viktrup L, Brown MT, West CR, Verburg KM. Long-Term Safety and Efficacy of Subcutaneous Tanezumab Versus Nonsteroidal Antiinflammatory Drugs for Hip or Knee Osteoarthritis: A Randomized Trial. Arthritis Rheumatol. 2021 Jul;73(7):1167-1177. doi: 10.1002/art.41674. Epub 2021 Jun 7.