louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT04110548: Emotion and Craving Regulation Among Individuals With Internet Gaming Disorders
Official title: Emotion and Craving Regulation Among Individuals With Internet Gaming Disorder: Cognitive Appraisal and Mindfulness Capacities
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Internet Gaming Disorder
Emotion Regulation
Keywords: Emotion and craving regulation
Lead sponsor: Beijing Normal University
Sponsor class: OTHER
First posted: 2019-10-01
Enrollment: 60
Sex: ALL
Minimum age (years): 18
Maximum age (years): 30
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: BASIC_SCIENCE

Brief summary: To investigate the potential deficits in emotion and craving regulation capacities of drug-naïve young adults with Internet gaming disorder as compared with healthy controls.

Detailed description: The purpose of this study is to examine the differences in young adults' capacities of utilizing cognitive appraisal versus mindfulness to regulate negative emotions and/or craving in response to negative affective stimuli or gaming cues, respectively. This project will be conducted in Beijing, China.

Eligibility criteria: Inclusion Criteria:

Internet gaming disorders (IGD):

1, DSM-5 recommended diagnosis of Internet gaming disorder :

1. the scores of the 9 items of DSM-5 recommended diagnosis for Internet gaming disorder ≥ 5.
2. engagement in popular Internet games (e.g. Arena of Valor, League of Legends and Player Unknown's Battle Grounds) for over 20 hours per week for a minimum of 12 months.

2, the scores of the Y-IAT(Young-Internet addiction Test) ≥ 50

Healthy controls (HCs): DSM-5 scores less than 5 and less than 20 hours gaming time per week.

Exclusion Criteria:

current or history of use of illegal substances and gambling; current or history of psychiatric or neurological illness; current use of psychotropic medications; being left-handed.

Primary outcomes:
measure: Behavioral outcome
timeFrame: 30- 40 minutes after training
measure: Behavioral outcome
timeFrame: 40- 60 minutes after training
measure: Behavioral outcome
timeFrame: 60- 80 minutes after training
Secondary outcomes:
Other outcomes:
Locations:
city: Beijing
country: China
facility: Beijing Normal University
state: Beijing
Study officials:
affiliation: Beijing Normal University
name: Nan Zhou, PhD
role: PRINCIPAL_INVESTIGATOR
References:
citation: Yip SW, Gross JJ, Chawla M, Ma SS, Shi XH, Liu L, Yao YW, Zhu L, Worhunsky PD, Zhang J. Is Neural Processing of Negative Stimuli Altered in Addiction Independent of Drug Effects? Findings From Drug-Naive Youth with Internet Gaming Disorder. Neuropsychopharmacology. 2018 May;43(6):1364-1372. doi: 10.1038/npp.2017.283. Epub 2017 Nov 20.
citation: Westbrook C, Creswell JD, Tabibnia G, Julson E, Kober H, Tindle HA. Mindful attention reduces neural and self-reported cue-induced craving in smokers. Soc Cogn Affect Neurosci. 2013 Jan;8(1):73-84. doi: 10.1093/scan/nsr076. Epub 2011 Nov 22.
Clinical trial NCT02913248: Salivary Bacterial Profiles in Relation to Periodontal Treatment
Official title: Short and Long Term Alterations of Subgingival and Salivary Microbiota in Relation to Periodontal Treatment
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Periodontitis
Keywords: periodontitis
saliva
bacteria
Lead sponsor: University of Copenhagen
Sponsor class: OTHER
Collaborators: name: The Forsyth Institute
name: Rigshospitalet, Denmark
First posted: 2016-09-23
Enrollment: 30
Sex: ALL
Minimum age (years): 40
Maximum age (years): 99
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: DIAGNOSTIC

Brief summary: The purpose of the present investigation is to record and compare bacterial compositions in subgingival plaque samples and saliva samples in subjects receiving periodontal treatment. The hypothesis is that the composition of the salivary microbiota might reflect local bacterial alterations in relation to periodontal treatment.

Detailed description: In this study we plan to enroll 35 subjects with manifest periodontitis, which will be treated according to national and international guidelines. Clinical registration and collection of subgingival plaque samples and saliva samples will be performed at baseline and 2, 6 and 12 weeks after treatment.

Eligibility criteria: Inclusion Criteria:

- Manifest chronic periodontitis according to international classification

Exclusion Criteria:

* Other treatment requiring oral conditions
* Systemic antibiotics within the latest 6 months
* Systemic diseases and medications with known associations to periodontitis
* Pregnancy and breastfeeding

Primary outcomes:
measure: Changes in α-diversity in saliva samples collected .
timeFrame: Baseline and 12 weeks
Secondary outcomes:
measure: Specis specific changes in saliva samples collected
timeFrame: Baseline and 12 weeks
Other outcomes:
Locations:
city: Copenhagen
country: Denmark
facility: University of Copenhagen, Department of Odontology
Study officials:
affiliation: University of Copenhagen
name: Daniel Belstrøm, DDS, PhD
role: PRINCIPAL_INVESTIGATOR
References:
citation: Grande MA, Belstrom D, Damgaard C, Holmstrup P, Thangaraj SS, Nielsen CH, Palarasah Y. Complement split product C3c in saliva as biomarker for periodontitis and response to periodontal treatment. J Periodontal Res. 2021 Jan;56(1):27-33. doi: 10.1111/jre.12788. Epub 2020 Jul 18.
citation: Grande MA, Belstrom D, Damgaard C, Holmstrup P, Kononen E, Gursoy M, Gursoy UK. Salivary concentrations of macrophage activation-related chemokines are influenced by non-surgical periodontal treatment: a 12-week follow-up study. J Oral Microbiol. 2019 Dec 9;12(1):1694383. doi: 10.1080/20002297.2019.1694383. eCollection 2020.
Clinical trial NCT04825548: Post-thrombotic Syndrome After Deep Venous Thrombosis (DVT) in Patients Treated According to the NOPHO ALL2008 Protocol
Official title: Post-thrombotic Syndrome After Deep Venous Thrombosis (DVT) in Patients Treated According to the NOPHO ALL2008 Protocol
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Acute Lymphoblastic Leukemia
Post Thrombotic Syndrome
Lead sponsor: Aarhus University Hospital
Sponsor class: OTHER
First posted: 2021-04-01
Enrollment: 27
Sex: ALL
Minimum age (years): 1
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: CASE_ONLY
Time perspective: CROSS_SECTIONAL
Sampling method: PROBABILITY_SAMPLE
Study population: All patients between 1.0-45 years of age and diagnosed with DVT and PE during treatment on the NOPHO ALL2008 protocol. In this period, 115 patients were diagnosed with DVT

Brief summary: Acute lymphoblastic leukemia (ALL) is the most common malignant disease in childhood. Today more than 90% of children and 75% of adults (18-45 years) survive ALL. The enzyme Asparaginase (Asp) is an indispensable part of the multiagent treatment of ALL.

Treatment related severe acute toxicities are common. Especially in teenagers and adults, thromboembolism is one of the most common acute toxicities and may result in post thrombotic syndrome (PTS) or pulmonary hypertension. The knowledge about these late effects is limited, including for ALL patients.


Eligibility criteria: Inclusion Criteria:

* Treated on the ALL2008 protocol for ALL. Had a DVT on treatment.

Exclusion Criteria:

* Death

Primary outcomes:
measure: Number of patients with post thrombotic syndrome
timeFrame: 01112020-01022023
Secondary outcomes:
Other outcomes:
Locations:
city: Aarhus N
country: Denmark
facility: Aarhus University Hospital
state: Vælg En Region, Stat Eller Provins.
Study officials:
References:
Clinical trial NCT01912248: Acute Effect of Strength Training on Blood Pressure in Cardiac Patients
Official title: Acute Effect of Strength Training on Blood Pressure in Cardiac Patients
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Heart Failure
Ischemic Heart Disease
Heart Transplant Recipients
Keywords: acute rise of systolic and diastolic bloodpressure
Lead sponsor: Bispebjerg Hospital
Sponsor class: OTHER
First posted: 2013-07-31
Enrollment: 36
Sex: ALL
Minimum age (years): 18
Maximum age (years): 80
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: CASE_ONLY
Time perspective: CROSS_SECTIONAL
Sampling method: PROBABILITY_SAMPLE
Study population: 12 heart transplant recipients 12 heart failure patients 12 patients with ischemic disease

Brief summary: Moderate and heavy strength training exercise and the acute blood pressure rise in cardiac patient, how high?

Detailed description: 12 heart transplant recipients 12 heart failure patients 12 patients with ischemic heart disease

Eligibility criteria: Inclusion Criteria:

* 18 years
* no strength training \> 3 month
* speak and understand danish

Exclusion Criteria:

* cancer
* serum creatinin above 200 mmol/l
* re-transplantation
* Ejection fraction \> 35

Primary outcomes:
measure: systolic blood pressure
timeFrame: one test, 1 hour, continuated systolic blood pressure surveliance
Secondary outcomes:
measure: diastolic blood pressure
timeFrame: one test 1 hour, continuated bloodpressure surveliance
Other outcomes:
Locations:
city: Copenhagen
country: Denmark
facility: Christian Dall
Study officials:
affiliation: Bispebjerg Hospital, Denmark
name: Christian H Dall, cand.scient
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT03204448: Clinical Performance of BioCLIA Ro60
Official title: Evaluation of Clinical Performance of Serologic Anti-Ro60 Autoantibody Detection Kit on BioCLIA Platform
Study type: OBSERVATIONAL
Overall status: WITHDRAWN
Conditions: Systemic Lupus Erythematosus
Sjogren's Syndrome
Lead sponsor: HOB Biotech Group
Sponsor class: INDUSTRY
First posted: 2017-07-02
Enrollment: 0
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: RETROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Multiple sites for clinically leftover samples accessed through Access Biologicals not confined to any demographic groups, general health status nor geographic locations

Brief summary: The study is to evaluate the clinical performance of BioCLIA Ro60 for measuring the autoantibody in autoimmune disease patients.

Detailed description: 100-200 clinically-diagnosed disease samples, as well as approximately 300 samples of various control diseases, will be used in the study. The specimen will be collected as the clinically leftover samples that have been used for routine clinical diagnosis purpose or research purpose, and with de-identification methods. Each set of samples will also be tested on a control serologic Anti-Ro60 detection kit, QUANTA Flash Ro60. Clinical sensitivity and clinical specificity will be analyzed for, also a method comparison conclusion will be drawn by comparing the two methods.

Eligibility criteria: Inclusion Criteria:

* Diagnosed with relevant diseases, including Systemic lupus erythematosus (SLE) and Sjogren's syndrome (SS)
* Or diagnosed with other control diseases, including Rheumatoid arthritis (RA), Infectious diseases and others

Exclusion Criteria:

* Treatment with medicine that submerge the autoantibody concentration to non-detectable range
* Co-diagnosed with multiple relevant diseases (e.g., SLE / SS) and/or control diseases
* Hemolyzed sample.

Primary outcomes:
measure: Clinical performance of BioCLIA Ro60
timeFrame: 10 months
Secondary outcomes:
measure: Method comparison between BioCLIA Ro60 and BioFlash/QUANTA Flash Ro60
timeFrame: 2 months
Other outcomes:
Locations:
city: Irvine
country: United States
facility: CRM Biotech
state: California
Study officials:
affiliation: CRM Biotech
name: Polly Chan, PhD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT02934048: Optimal Duration of Antimicrobial Susceptibility Test (AST) Guided Rescue Therapy for Helicobacter Pylori Infection
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: PHASE4
Conditions: Therapeutic Duration
Helicobacter Pylori
Antimicrobial Susceptibility Test
Eradication
Lead sponsor: Shandong University
Sponsor class: OTHER
First posted: 2016-10-14
Enrollment: 700
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: Strongly evidence supports that H. pylori eradication is an effective approach to reduce the incidence of those pathologies. However, due to the increasing resistance rates to antibiotics, failures of H. pylori eradication get more and more common. Thus, rescue therapy for persistent H. pylori infection is becoming a grand challenge the investigators have to face.


Eligibility criteria: Inclusion Criteria:

* Patients require upper endoscopy owing to persistent H. pylori infection despite one or more treatment attempts.

Exclusion Criteria:

* Age younger than 18 years;
* Patients with gastrectomy, acute GI bleeding and advanced gastric cancer;
* Known or suspected allergy to study medications;
* Inability to provide informed consent and other situations that could interfere with the examination or therapeutic protocol.

Primary outcomes:
measure: The different rate of H. pylori eradication among 3 different course of treatments (7-day, 10-day and 14-day) guided by AST in intention-to-treat (ITT) analysis.
timeFrame: 9 months
measure: The different rate of H. pylori eradication among 3 different course of treatments (7-day, 10-day and 14-day) guided by AST in per-protocol (PP) analysis.
timeFrame: 9 months
Secondary outcomes:
measure: the rate of improving dyspepsia symptoms after H. pylori eradication
timeFrame: 9 months
measure: the rate of adverse events happening
timeFrame: 9 months
Other outcomes:
Locations:
Study officials:
affiliation: Qilu Hospital of Shandong University
name: Li Yanqing, MD, PhD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT00748748: Effect of Lactobacillus Probiotic on Healthy Adults
Official title: Effect of Lactobacillus Probiotic on Healthy Adults
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE1
Conditions: Antibiotic-associated Diarrhea
Lead sponsor: Fargo VA Medical Center
Sponsor class: FED
First posted: 2008-09-09
Enrollment: 20
Sex: ALL
Minimum age (years): 18
Maximum age (years): 64
Standard ages: ADULT
Accepts healthy volunteers: no
Allocation: NON_RANDOMIZED
Intervention model: SINGLE_GROUP
Primary purpose: PREVENTION

Brief summary: Diarrhea is a common side effect of antibiotics; it may prolong hospital stay, increase the risk of other infections, develop into more serious forms of disease, and lead to premature discontinuation of the needed antibiotic. The purpose of this study is to examine the safety and effectiveness of a capsule containing Lactobacillus rhamnosus GG in the prevention of diarrhea associated with antibiotic use.


Eligibility criteria: Inclusion Criteria:

* Participants (male or female inpatients) 18 to 64 years of age who are prescribed antibiotics (single or multiple antibiotics, oral or intravenous) will be recruited from the Fargo VAMC Primary Care Clinic area.
* Participants must be able to swallow a capsule.

Exclusion Criteria:

* Exclusion criteria include diarrhea on admission or within the preceding week
* Reported recurrent diarrhea
* Antibiotics in the past four weeks
* Significant underlying conditions (e.g. diabetes, structural cardiac defects including valvular defects, history of infective endocarditis, poor cardiac function, immunosuppression, impaired gut integrity, moderate or serious intestinal disorders, malignancies, pancreatitis, indwelling catheters, recent surgery, recent prolonged hospitalization)
* Previous bowel surgery
* Nutritional restrictions that preclude participation
* Hypersensitivity to penicillin G, ampicillin, or erythromycin
* Persons who have been prescribed their antibiotic for a duration longer than 3 weeks

Primary outcomes:
measure: Incidence of diarrhea
timeFrame: Approximately one month
Secondary outcomes:
Other outcomes:
Locations:
city: Fargo
country: United States
facility: Fargo VA Medical Center
state: North Dakota
Study officials:
References:
Clinical trial NCT03981848: Radiomics-based Non-invasive Classifier Research for HCC-related Liver Transplantation
Official title: Radiomics-based Non-invasive Classifier Research for HCC-related Liver Transplantation
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Hepatocellular Carcinoma
Liver Transplantation
Magnetic Resonance Imaging
Lead sponsor: Zhejiang University
Sponsor class: OTHER
Collaborators: name: Fudan University
First posted: 2019-06-11
Enrollment: 200
Sex: ALL
Minimum age (years): 18
Maximum age (years): 70
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: RETROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: hospitalization patients

Brief summary: The purpose of this study is to establish a non-invasive radiomics method to filter high recurrent-risk liver transplantation recipient population

Detailed description: Hepatocellular carcinoma is one of the most common malignant tumors in the world with high incidence and mortality. Liver transplantation is the most effective treatment for HCC and is in high demand in China. However, recurrence of HCC among liver transplantation recipients is still a great challenge and threat to the survival of recipients. So it is of great significance to establish a non-invasive way to filter high liver transplantation recipient population before transplantation. Based on large scales of pre-treatment MR images, the investigator's study aims to establish a non-invasive radiomics method to filter high recurrent-risk liver transplantation recipient population. This study will contribute to the precise selection of HCC-related liver transplantation recipients.

Eligibility criteria: Inclusion Criteria:

* All patients had postoperative pathological diagnosis of HCC
* All patients had underwent contrast-enhanced MRI scan within 2 weeks before liver transplantation

Exclusion Criteria:

* patients whose pathological diagnosis is not HCC
* patients whose CT images were affected by strong imaging artifacts, i.e. artifacts obscuring more than 10% of whole volume of interest
* patients whose clinical data or CT images were missing

Primary outcomes:
measure: tumor recurrent status
timeFrame: two years
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
References:
Clinical trial NCT01432548: Ischemic Preconditioning. Prospective Comparison
Official title: Ischemic Preconditioning Versus Intermittent Portal Triad Clamping in Liver Resection. Prospective Randomized Comparison
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Ischemic Lesions
Keywords: Ischemic
preconditioning
liver
resection
Lead sponsor: Hospital General de Agudos "Dr. Cosme Argerich"
Sponsor class: OTHER
First posted: 2011-09-13
Enrollment: 60
Sex: ALL
Minimum age (years): 18
Maximum age (years): 90
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: Vascular occlusion is used to reduce blood loss during liver resection (LR), but may cause ischemic damage to the remnant liver and can lead to liver failure in case of chronic liver disease. This restriction of blood flow (ischemia) and subsequent restoration (reperfusion) causes a harm that is called ischemia- reperfusion injury. Injuries sustained during the ischemic phase are related to a lack of oxygen to reduce cellular respiratory events can lead to, in a few minutes, irreversible damage. Ischemic preconditioning as a technique to protect the liver parenchyma during liver resection consists of an initial flow clamping for 10 minutes, with subsequent reperfusion for 10-15min, followed by a complete portal triad clamping during transection.

Detailed description: Detailed Description:

This is a prospective controlled trial, conducted between July 2011 and July 2012. This study has been initiated by Liver \& Transplant Division, Hospital Dr Cosme Argerich, Buenos Aires Argentina. The protocol was approved by ethics committees and an informed consent was obtained from each patient before they were enrolled. Sixty patients were randomized to either receive ischemic preconditioning prior to liver resection under intermittent pedicle clamping or Intermittent Pringle ischemia. Ischemic preconditioning was performed through a sequence of 10 minutes vascular inflow occlusion and 10 minutes of reperfusion prior to continuous pedicle clamping during resection. Intermittent pedicle clamping was conducted through a sequence of 15 minutes of vascular inflow occlusion and 5 minutes of reperfusion. The randomization process which was centralized was held in the operating room after inclusion criteria had been check and exclusion criteria ruled out.

Eligibility criteria: Inclusion Criteria:

* patients' age ≥ 18 years old
* Portal vein embolization allowed

Exclusion Criteria:

* laparoscopic liver resection
* pregnant women
* lack of patient consent
* lack of acceptance of the operating surgeon
* Hilar cholangiocarcinoma
* Simultaneous hepaticojejunostomy

Primary outcomes:
measure: Mortality Complications
timeFrame: within 30 days after surgery
Secondary outcomes:
measure: Operative variables,markers of liver function and injury, pathological parenchymal characteristics
timeFrame: within 30 days after surgey
Other outcomes:
Locations:
city: Buenos Aires
country: Argentina
facility: Hospital Dr Cosme Argerich
Study officials:
References:
Clinical trial NCT00425048: Does Gloved Medical Personnel Scratch Less Often?
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Hygiene
Equipment Contamination
Health Education
Lead sponsor: Medical University Innsbruck
Sponsor class: OTHER
First posted: 2007-01-22
Enrollment: 40
Sex: ALL
Minimum age (years): 18
Maximum age (years): 30
Standard ages: ADULT
Accepts healthy volunteers: yes
Time perspective: PROSPECTIVE

Brief summary: Unconscious touching of a person's own head or neck (for example by scratching) is a frequently observed and completely normal physiological movement pattern in humans, which when done by medical personnel attending a patient poses a high risk of unconscious self-contamination, even of an already disinfected hand, and of subsequent contamination of the patient. However, as compared to an ungloved hand, a gloved hand is felt to be "foreign," which could reduce the frequency of self-contact and thus the contamination rate.

Wearing protective gloves is highly recommended in medical practice. The purpose of this study is to explore how wearing, or not wearing, protective gloves affects

* the frequency of unconscious self-contact
* contamination of the gloved/ungloved hand


Eligibility criteria: Inclusion Criteria:

* Medical students working in a simulated OR environment

Primary outcomes:
Secondary outcomes:
Other outcomes:
Locations:
city: Innsbruck
country: Austria
facility: University Hospital
Study officials:
affiliation: MUI Innsbruck
name: Arnulf Benzer, MD
role: PRINCIPAL_INVESTIGATOR
References: