Clinical trial NCT04945278: Study of Self-Recognition and Self/Other Distinction Disorders in Patients With Psychological Vulnerability
Official title: Study of Self-Recognition and Self/Other Distinction Disorders in Patients With Psychological Vulnerability (ALTER EGO)
Study type: INTERVENTIONAL
Overall status: RECRUITING
Phase: NA
Conditions: Psychosis of Childhood Borderline
Psychotic Disorder
Keywords: Mental Vulnerability
Self-recognition
Psychosis High-Risk State
Self-other Distinction
Double Mirror Paradigm
Schizophrenia
Lead sponsor: University Hospital, Brest
Sponsor class: OTHER
First posted: 2021-06-30
Enrollment: 34
Sex: ALL
Minimum age (years): 15
Maximum age (years): 25
Standard ages: CHILD
ADULT
Accepts healthy volunteers: yes
Allocation: NON_RANDOMIZED
Intervention model: PARALLEL
Intervention model description: Prospective interventional case / control trial
Primary purpose: BASIC_SCIENCE

Brief summary: The main objective of this study is to establish whether there are differences in self-recognition and self/other distinction in subjects with psychological vulnerability compared to healthy volunteer controls.

Detailed description: This study is based on the properties of the double mirror "Alter Ego" which is a device that appears as a double-sided mirror surrounded by light diodes whose intensity can be varied. Thanks to this variation of luminosity, this special paradigm creates morphs between two real subjects seated on both sides, resulting in different faces, each morphed to a varying extent.

In this task, participants watch a double mirror in which a picture of their own face gradually transforms into the face of an unfamiliar other (self-to-other direction) or vice versa (other-to-self direction), and indicate at which point they judge the morph to look more like the target face than the starting face.

The comparison of the thresholds obtained by different individuals makes it possible to establish whether there could be differences between subjects with psychological vulnerability and healthy controls and to explore hypothetical links between self/other distinction abilities and symptoms of psychological vulnerability .

Eligibility criteria: Inclusion criteria for patients:

* Aged from 15 to 25 years
* Subject meeting the Ultra High Risk criteria at CAARMS and / or SPI-A
* Signature of the consent (participants and parents for minors)
* Subject affiliated to the social security scheme or benefiting from such a scheme

Inclusion criteria for healthy volunteers:

* Aged from 15 to 25 years
* Subject not familiar to the patient to whom it is matched
* Signature of the consent (participants and parents for minors)
* Subject affiliated to the social security scheme or benefiting from such a scheme

Exclusion Criteria for both patients and healthy volunteers:

* History of epilepsy and / or migraine (due to the epileptogenic potential of light stimuli)
* Refusal of participation of the minor even if the legal representatives want the subject to participate in the study
* Claustrophobia
* Wearing glasses
* Abnormal right and left visual acuity without contact lenses
* Distinctive signs on the face which cannot be temporarily removed
* Subject under legal protection (curators / guardianship) or deprived of liberty

Primary outcomes:
measure: Average of the three M1
timeFrame: Inclusion
Secondary outcomes:
measure: The average of the three M2
timeFrame: Inclusion
measure: Results to tests for early prodromal symptoms assessed by SPI-A (Schizophrenia Prediction Instrument for Adults)
timeFrame: Inclusion
measure: Results to tests for early prodromal symptoms assessed by PQ16 (Prodromal Questionnaire - 16)
timeFrame: Inclusion
measure: Results to tests for early prodromal symptoms assessed by EASE(xamination of Anomalous Self-Experience)
timeFrame: Inclusion
measure: Results to tests for later prodromal symptoms
timeFrame: Inclusion
measure: Results to tests concerning the peculiarities of cognitive functioning (neuropsychological assessment) assessed by Wechsler scale
timeFrame: Inclusion
measure: Results to social functioning test:
timeFrame: Inclusion
Other outcomes:
Locations:
city: Bohars
country: France
facility: CHRU BREST Hôpital de Bohars
Study officials:
affiliation: CHRU BREST
name: Nathalie LAVENNE
role: PRINCIPAL_INVESTIGATOR
References:
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citation: Fusar-Poli P, Borgwardt S, Bechdolf A, Addington J, Riecher-Rossler A, Schultze-Lutter F, Keshavan M, Wood S, Ruhrmann S, Seidman LJ, Valmaggia L, Cannon T, Velthorst E, De Haan L, Cornblatt B, Bonoldi I, Birchwood M, McGlashan T, Carpenter W, McGorry P, Klosterkotter J, McGuire P, Yung A. The psychosis high-risk state: a comprehensive state-of-the-art review. JAMA Psychiatry. 2013 Jan;70(1):107-20. doi: 10.1001/jamapsychiatry.2013.269.
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citation: Keromnes G, Chokron S, Celume MP, Berthoz A, Botbol M, Canitano R, Du Boisgueheneuc F, Jaafari N, Lavenne-Collot N, Martin B, Motillon T, Thirioux B, Scandurra V, Wehrmann M, Ghanizadeh A, Tordjman S. Exploring Self-Consciousness From Self- and Other-Image Recognition in the Mirror: Concepts and Evaluation. Front Psychol. 2019 May 7;10:719. doi: 10.3389/fpsyg.2019.00719. eCollection 2019.
citation: Uddin LQ, Davies MS, Scott AA, Zaidel E, Bookheimer SY, Iacoboni M, Dapretto M. Neural basis of self and other representation in autism: an FMRI study of self-face recognition. PLoS One. 2008;3(10):e3526. doi: 10.1371/journal.pone.0003526. Epub 2008 Oct 29.
citation: Ionta S, Gassert R, Blanke O. Multi-sensory and sensorimotor foundation of bodily self-consciousness - an interdisciplinary approach. Front Psychol. 2011 Dec 23;2:383. doi: 10.3389/fpsyg.2011.00383. eCollection 2011.
citation: Parnas J, Moller P, Kircher T, Thalbitzer J, Jansson L, Handest P, Zahavi D. EASE: Examination of Anomalous Self-Experience. Psychopathology. 2005 Sep-Oct;38(5):236-58. doi: 10.1159/000088441. Epub 2005 Sep 20. No abstract available.