louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT06849440: Effectiveness of Childbirth Preparation Education
Official title: The Effect of Childbirth Preparation Education on Perceived Stress and Traumatic Birth Perception in Pregnant Women
Study type: INTERVENTIONAL
Overall status: NOT_YET_RECRUITING
Phase: NA
Conditions: Perception of Traumatic Birth
Perceived Stress
Keywords: childbirth
childbirth preparation
percieved stress
perception of traumatic birth
Lead sponsor: Antalya Bilim University
Sponsor class: OTHER
First posted: 2025-02-27
Enrollment: 38
Sex: FEMALE
Minimum age (years): 18
Maximum age (years): 40
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: SUPPORTIVE_CARE

Brief summary: The act of birth, which is considered a natural event, is an act that the mother will remember with positive experiences in her life if it progresses normally. However, sometimes birth can be perceived as stressful and traumatic for women. Stress during pregnancy is a problem that should be emphasized and managed due to its negative effects on the health of the mother and the baby. As the pregnancy progresses, the levels of stress hormones may increase. In addition, the thought of spontaneous birth exposes women to physical discomfort, stress and uncertainty during pregnancy. The perception of traumatic birth is an important concept that emerges as a result of the woman's mental birth scenario, the information she has acquired about birth, and every situation she experiences during the birth, and also affects the postpartum period. In studies conducted in Turkey using the Traumatic Birth Perception Scale, it was determined that 23.6% and 26.9% of women experienced a high level of traumatic birth perception. Nulliparity, negative feelings about birth, inadequate antenatal care, inadequate psychosocial support, risky pregnancies, and lack of information about birth are among the factors that may cause traumatic birth perception. Physical and mental preparation for birth and information about pain management are considered to be the basic elements of prenatal education classes. There are study results indicating that birth preparation classes benefit women in many aspects such as self-sufficiency, reduced fear of birth, and positive pregnancy experience. No study results have been found in the literature examining the effect of birth preparation education on the perception of traumatic birth during pregnancy. Based on this, this study was needed to examine the effect of pregnant women's participation in childbirth preparation training on their perceived stress level and perception of traumatic birth.


Eligibility criteria: 28-34th weeks of pregnancy Agree to participate in the study Be literate Be able to speak and understand Turkish

Primary outcomes:
measure: Perceived Stress Scale (PSS)
timeFrame: Pre-test and immediately post-test
Secondary outcomes:
measure: Traumatic Birth Perception Scale (TBPS)
timeFrame: Pre-test and immediately post-test
Other outcomes:
Locations:
Study officials:
References:
Clinical trial NCT04458740: The Life and Care of Colorectal Cancer Patients After 65 Years and Their Family
Official title: The Life and Care of Colorectal Cancer Patients After 65 Years and Their Family
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Colorectal Cancer
Lead sponsor: Poitiers University Hospital
Sponsor class: OTHER
First posted: 2020-07-07
Enrollment: 18
Sex: ALL
Minimum age (years): 65
Maximum age (years): 80
Standard ages: OLDER_ADULT
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Surviving patients between 65 and 80 years and diagnosed with invasive CRC, infiltrating adenocarcinoma of the colon or rectum irrespective of the stage before 65 years old will be selected in the Poitou-Charentes cancer registry 2 to 5 years after announcement of the diagnosis.

Brief summary: Given a context where patients autonomy respect is important, it is necessary to pay a sustained attention to the patients care and life experiences, as well as the families and relatives of patients with colorectal cancer or patients in remission of colorectal cancer. Thanks to families and relatives data, it will allow to improve the analyses carried out by the "Societal Cancer Observatory" in 2016.


Eligibility criteria: Inclusion Criteria:

The patients will be:

* over the age of 65 and under 80
* with a colorectal cancer operated between 65 and 80 years with a documented histological diagnosis, dating from 2 to 5 years.
* be able to provide informed consent and appoint a caregiver who would be willing to participate in the study.

The spouse and / or children and / or parents will be eligible:

if he is at least 18 years old, if he can be considered a caregiver of the index patient for whom a diagnosis of CRC has been made.

Exclusion Criteria:

* Patients with a diagnosis of colorectal cancer before the age of 65 or after the age of 80 from 2 to 5 years old.

Near a deceased patient or under 18 years old.

Primary outcomes:
measure: Assess the interaction between the care path (surgery, chemotherapy, radiotherapy) and the life course in patients after 65 years old with colorectal cancer
timeFrame: 2 hours
measure: Assess how the patients and their family members face the disease
timeFrame: 1 hour
Secondary outcomes:
Other outcomes:
Locations:
city: Poitiers
country: France
facility: Registre du Cancer
Study officials:
References:
Clinical trial NCT06681844: Predict Tooth Wear
Official title: Prediction of the Tooth Wear Index Based on a Dataset of Dental Shapes:a Retrospective Study
Study type: OBSERVATIONAL
Overall status: RECRUITING
Conditions: Prediction of Tooth Wear
Lead sponsor: Hospices Civils de Lyon
Sponsor class: OTHER
First posted: 2024-11-08
Enrollment: 1000
Sex: ALL
Minimum age (years): 18
Maximum age (years): 80
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: RETROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: Avulsed teeth at the Oral Surgery Departement of the Lyon Dental University Hospital

Brief summary: Tooth wear, resulting from gradual loss of dental hard tissue due to mechanical and chemical factors, impacts tooth structure, texture, and function. It affects quality of life, with varying prevalence (26.9% to 90.0%), and is traditionally detected visually during check-ups, often at advanced stages. Monitoring alterations in tooth shape via intraoral scanners aids early detection, but restoration remains challenging. Prevention through early detection is vital, as patients may not fully comprehend tooth structure loss until visible. Recently, statistical shape analysis (SSA) used to learn the tooth anatomy and define a reference shape (biogeneric tooth) using. However, assuring landmark consistency is challenging mostly due to biases of the operator. Recently, a robust method called MEG-IsoQuad offered automated, isotopological remeshing. Combining this with SSA holds promise for diagnostic and simulation purposes. This study aims to assess the reliability of a remeshing-SSA approach for altered and intact premolar analysis and compare machine learning algorithms for simulating the shape of the initially intact tooth or future altered one.

The clinical perspective of the current work offers possibilities to:

* Prevent future tooth wear by detecting it at an early stage; and communicate better to the patient by presenting him/her potential future altered teeth
* Simulate the adapted reconstruction for the altered tooth by simulating the initially intact one


Eligibility criteria: Inclusion Criteria:

* teeth avulsed presenting a tooth wear index between 0 and 3
* mature incisor, canine, premolar or molars (1st and 2nd only)

Exclusion Criteria:

* teeth avulsed presenting a tooth wear index over 3 (or presenting an oral rehabilitation representative of a similar wear)
* immature teeth or teeth without root edification
* wisdom teeth

Primary outcomes:
measure: Prediction of the tooth wear index based on a dataset of dental shapes:a retrospective study
timeFrame: only once
Secondary outcomes:
Other outcomes:
Locations:
city: Indianapolis
country: United States
facility: Indiana University Hospital
state: Indiana
city: Leuven
country: Belgium
facility: KU Leuven University Hospital
city: Lyon
country: France
facility: Lyon Dental Hospital
city: Lucknow
country: India
facility: King George Medical University
city: Tel Aviv
country: Israel
facility: Tel Aviv Universi
Study officials:
References:
Clinical trial NCT02307344: Effect of Nigella Sativa on Nonalcoholic Steatohepatitis and Steatosis
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Nonalcoholic Steatohepatitis
Liver Steatosis
Lead sponsor: Hillel Yaffe Medical Center
Sponsor class: OTHER_GOV
First posted: 2014-12-04
Enrollment: 100
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The investigators hypothesize that Nigella Sativa will have an effect on Nonalcoholic Steatohepatitis and Liver Steatosis by enhancing lipophagy in the liver tissue.


Eligibility criteria: Inclusion Criteria:

* Patients suffering from Steatohepatitis
* Patients suffering from Liver Steatosis

Exclusion Criteria:

* Patients suffering from viral hepatitis
* Patients with HIV infection
* Patients suffering from Wilsons Disease

Primary outcomes:
measure: Effect of Nigella Sativa on Liver Triglyceride Concentration
timeFrame: One year
Secondary outcomes:
measure: Effect of Nigella Sativa on Improvement in NASH Activity Index
timeFrame: One year
measure: Effect of Nigella Sativa on Fibrosis Staging
timeFrame: One year
Other outcomes:
Locations:
city: Hadera
country: Israel
facility: Hillel Yaffe Medical Center
Study officials:
References:
Clinical trial NCT04353544: Effect of Delayed vs Immediate Umbilical Cord Clamping on Maternal Blood Loss in Term Spontaneous Vaginal Delivery
Official title: Effect of Delayed vs Immediate Umbilical Cord Clamping on Maternal Blood Loss in Term Spontaneous Vaginal Delivery
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Post Partum Hemorrhage
Lead sponsor: Federico II University
Sponsor class: OTHER
Collaborators: name: Casa di Cura Accreditata Fabia Mater, Rome, Italy
First posted: 2020-04-20
Enrollment: 122
Sex: FEMALE
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: PREVENTION

Brief summary: Policies for timing of cord clamping vary, with early cord clamping generally carried out in the first 60 seconds aLer birth, whereas latercord clamping usually involves clamping the umbilical cord greater than one minute after the birth or when cord pulsation has ceased


Eligibility criteria: Inclusion Criteria:

* singleton pregnancy
* at term
* cephalic presentation
* spontaneous labor
* spontaneous vaginal delivery

Exclusion Criteria:

* multiple gestation
* preterm gestation
* induced labor
* operative delivery
* hypertension or preeclampsia
* fetal anomaly
* abnormal placentation
* planned cord blood banking
* maternal bleeding disorder

Primary outcomes:
measure: change in maternal hemoglobin level on post delivery day 1 compared with the predelivery hemoglobin level
timeFrame: day 1 after delivery
Secondary outcomes:
measure: postpartum hemorrhage
timeFrame: at the time of delivery
measure: uterotonic administration
timeFrame: at the time of delivery
measure: need for blood transfusion
timeFrame: at the time of delivery
measure: jaundice
timeFrame: day 10 of life
Other outcomes:
Locations:
city: Rome
country: Italy
facility: Casa di Cura Accreditata Fabia Mater, Rome, Italy
state: Roma
Study officials:
References:
citation: De Angelis C, Saccone G, Sorichetti E, Alagna M, Zizolfi B, Gragnano E, Legnante A, Sardo ADS. Effect of delayed versus immediate umbilical cord clamping in vaginal delivery at term: A randomized clinical trial. Int J Gynaecol Obstet. 2022 Dec;159(3):898-902. doi: 10.1002/ijgo.14223. Epub 2022 May 2.
Clinical trial NCT03191344: Extended Application of Intraoperative Parathyroid Scores System(IPSS) in Thyroidectomy
Official title: Extended Application of Intraoperative Parathyroid Scores System(IPSS) in Thyroidectomy
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Intraoperative Parathyroid Scores System
Keywords: Intraoperative Parathyroid Scores System
total thyroidectomy
thyroid cancer
hypoparathyroidism
prediction
Lead sponsor: Fujian Medical University
Sponsor class: OTHER
First posted: 2017-06-19
Enrollment: 300
Sex: ALL
Maximum age (years): 60
Standard ages: CHILD
ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: the patients with thyroid tumors and require surgery In accordance with the guidelines.

Brief summary: after established the Intraoperative Parathyroid Scores System (IPSS) for thyroidectomy we further extented the clinical value of Intraoperative Parathyroid Scores System in Treatment decisions of calcium treatment time and improve recognition skills of parathyroid in Clinicians

Detailed description: IPSS includes transplantation Parathyroid Scores and in situ Parathyroid Scores, the investigators will establish the Intraoperative Parathyroid Scores System by parathyroid size and Blood supply, and recording IPSS, according to certain rules. We expand IPSS, including the description of the location of parathyroid after postoperative.Parathyroid hormone and calcium were test in d0, d1, d14, d60 post operation. The correlation between Intraoperative Parathyroid Scores and PTH calcium were calculated, and ROC curve and logistic regression were tested for the prediction value.and after that we further evaluate the relationship Between IPSS and calcium supplement time.and Whether IPSS enhance ability of parathyroid recognition for clinical doctors.

Eligibility criteria: Inclusion Criteria:

1. postoperative pathology confirmed as thyroid papillary carcinoma;
2. for the first time to undergo thyroid surgery, no history of neck surgery and external radiotherapy;
3. preoperative serum calcium, parathyroid hormone levels were normal;
4. intraoperative and postoperative clinical data integrity, standardized follow-up patients;
5. parathyroid is a tumor violation.

Exclusion Criteria:

1. serious underlying disease;
2. age greater than 60 years of age or combined with arteriosclerotic disease;
3. patients with postoperative loss;
4. patients with parathyroid disease.

Primary outcomes:
measure: Differences of parathyroid records between IPSS and TD
timeFrame: 1 year
Secondary outcomes:
measure: The effect of IPSS on the level of parathyroid recognition of surgeons
timeFrame: 1 year
measure: differences of the number of parathyroid glands found in the pathology betwen IPSS and TD
timeFrame: 1 year
Other outcomes:
measure: The Predictive Value of IPSS for Intravenous and Oral Calcium duration
timeFrame: 1 year
Locations:
city: Fuzhou
country: China
facility: Wen-xin ZHAO
state: Fujian
Study officials:
References:
Clinical trial NCT05207644: Letrozole and Misoprostol for Termination of Pregnancy up to 63 Days' Gestation
Official title: Letrozole and Misoprostol for Termination of Pregnancy up to 63 Days' Gestation: A Pilot Study to Evaluate the Safety and Acceptably of a User-friendly Regimen
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE2
Conditions: Pregnancy
Lead sponsor: Gynuity Health Projects
Sponsor class: OTHER
First posted: 2022-01-26
Enrollment: 40
Sex: FEMALE
Minimum age (years): 18
Maximum age (years): 50
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: TREATMENT

Brief summary: Study to determine if a user-friendly medical abortion regimen using letrozole and misoprostol is safe and acceptable.


Eligibility criteria: Inclusion Criteria:

* Pregnancy ≤ 63 days gestational age by ultrasound seeking termination of pregnancy
* Pregnancy visible on ultrasound
* Speaks English or Spanish
* Willing and able to return for follow-up appointment

Exclusion Criteria:

* People with gestations \> 63 days gestational age
* Confirmed or suspected ectopic pregnancy or undiagnosed adnexal mass
* Pregnancy of unknown location
* IUD or contraceptive implant in place
* History of allergy to letrozole or misoprostol
* Unable to return for clinic-based follow-up
* Currently breastfeeding
* Twin or multiple pregnancy
* History of liver disease or abnormal liver function

Primary outcomes:
measure: Safety Profile of medical abortion regimen
timeFrame: 2 weeks
Secondary outcomes:
Other outcomes:
Locations:
city: Salt Lake City
country: United States
facility: Planned Parenthood Salt Lake Health Center
state: Utah
Study officials:
affiliation: Gynuity Health Projects
name: Tara Shochet, PhD, MPH
role: PRINCIPAL_INVESTIGATOR
affiliation: Gynuity Health Projects
name: Beverly Winikoff, MD, MPH
role: PRINCIPAL_INVESTIGATOR
affiliation: The University of Utah
name: David Turok, MD, MPH
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT00319644: Impact of Using Mini-Bronchoalveolar Lavage as a Diagnostic Test for Ventilator-Associated Pneumonia
Official title: Impact of Using Mini-Bronchoalveolar Lavage as a Diagnostic Test for Ventilator-Associated Pneumonia
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Ventilator-Associated Pneumonia
Lead sponsor: University of California, San Francisco
Sponsor class: OTHER
First posted: 2006-04-27
Enrollment: 37
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: SINGLE_GROUP
Primary purpose: DIAGNOSTIC

Brief summary: The proposed study will evaluate adult patients admitted to the medical or surgical intensive care units (ICUs) at San Francisco General Hospital (SFGH). On admission, patients will be randomized in a 1:1 manner to the mini-bronchoalveolar lavage (BAL) quantitative culture arm in the setting of suspected ventilator-associated pneumonia (VAP) versus the tracheal aspirate culture arm, which is the current test available at SFGH.

Detailed description: Patients will be randomized to either Mini-Bal or tracheal aspirate then samples will be taken to the lab for culture. Comparative analysis will then be performed based upon lab results.

Eligibility criteria: Inclusion Criteria:

* All adult patients (\> age 18) admitted to 5E, 5R, and 4E intensive care units and are on the ventilator for greater than 48 hours and expected to remain on the ventilator for awhile
* Study procedures would be performed only in patients clinically suspected of having VAP.

Exclusion Criteria:

* Severe respiratory distress at the time of suspected VAP defined by:

  * FiO2 ≥ 0.7
  * PEEP ≥ 12

Primary outcomes:
measure: Change in Antibiotic Usage or Exposure
timeFrame: It is theorized that patients randomized to the tracheal aspirate will receive an average of 15 days of antibiotics while patients randomized under the minibal arm will receive an average of 10 days of antibiotics
measure: Antibiotics Exposure Days
timeFrame: 15 days
Secondary outcomes:
Other outcomes:
Locations:
city: San Francisco
country: United States
facility: San Francisco General Hospital
state: California
Study officials:
affiliation: University of California, San Francisco
name: Julin F Tang, M.D., M.S.
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT04558944: The Effect of Extracorporeal Shock Wave Therapy in the Treatment of Post Burn Scars
Official title: Clinical Use of the Extracorporeal Shock Wave Therapy in the Treatment of Pathological Post Burn Scars
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Cicatrix, Hypertrophic
Lead sponsor: Hospital Universitari Vall d'Hebron Research Institute
Sponsor class: OTHER
First posted: 2020-09-22
Enrollment: 40
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Intervention model description: Two randomized groups with twenty patients per group. The control group received the standard treatment for postburn scars. The treatment group (ESWT) received the standard treatment and treatment of postburn scars with ESWT 512 impulses of o.15mJ/mm 2 in each session, twice per week for 4 weeks.
Primary purpose: TREATMENT

Brief summary: A prospective, randomized, controlled study. The patients were divided into two groups with twenty patients per group. The control group received the standard treatment for postburn scars. The treatment group received the standard treatment and treatment of postburn scars with Extracorporeal Shock Wave Therapy 512 impulses of 0.15mJ/mm 2 in each session, twice per week for 4 weeks.

The investigators assessed the appearance of scar with the Vancouver Scar Scale (VSS), pruritus and pain with Visual Analog Scale (VAS) before the start of the treatment and at 2 weeks and 5 months after the treatment.


Eligibility criteria: Inclusion Criteria:

* Patients with hypertrophic post burn scars of approximately 64 cm2 surface area.

Exclusion Criteria:

* Patients younger than 18 year.
* Pregnant women.
* Having a known skin condition (e.g. psoriasis, skin cancer etc.).
* Immunosuppression.
* Hemophilia .
* Matured scars.
* Scars located above the lungs, the bowels, the gonads or electronic implants.

Primary outcomes:
measure: Scar appearance
timeFrame: 6 months from inclusion
Secondary outcomes:
measure: Scar pruritus
timeFrame: 6 months from inclusion
measure: Scar pain
timeFrame: 6 months from inclusion
Other outcomes:
Locations:
city: Barcelona
country: Spain
facility: Jorge Aguilera Sáez
Study officials:
References:
Clinical trial NCT06424444: A Clinical Trial to Assess the Safety and Efficacy of Subjects With Dry Eye Disease
Official title: A Multicenter, Phase 3, Randomized, Double-Masked, Parallel-Group, Vehicle-Controlled, Environment Exposure Clinical Trial to Assess the Efficacy and Safety of 0.25% Reproxalap Ophthalmic Solution Compared to Vehicle in Subjects With Dry Eye Disease
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE3
Conditions: Dry Eye Disease
Lead sponsor: Aldeyra Therapeutics, Inc.
Sponsor class: INDUSTRY
First posted: 2024-05-22
Enrollment: 421
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: A Multicenter, Phase 3, Randomized, Double-Masked, Parallel-Group, Vehicle-Controlled, Environment Exposure Clinical Trial to Assess the Efficacy and Safety of 0.25% Reproxalap


Eligibility criteria: Inclusion Criteria:

* at least 18 years of age;
* written informed consent and sign the Health Information Portability and Accountability Act (HIPAA) form;
* history of use or desire to use eye drops for dry eye symptoms within 6 months of Visit 1

Exclusion Criteria:

* ongoing ocular infection (bacterial, viral, or fungal) or active ocular inflammation at Visit 1;
* contact lenses within 7 days of Visit 1 or anticipate using contact lenses during the trial;
* eye drops within 2 hours of Visit 1;
* laser-assisted in situ keratomileusis (LASIK) surgery within the last 12 months;
* topical ocular cyclosporine, lifitegrast, corticosteroid, or any other topical ocular prescription medication within 90 days of Visit 1

Primary outcomes:
measure: Subject-reported ocular discomfort score over Week 1 to Week 6
timeFrame: From Day -14 to Day 43
Secondary outcomes:
Other outcomes:
Locations:
city: Shelby
country: United States
facility: Core, Inc.
state: North Carolina
Study officials:
References: