Clinical trial NCT05188456: The Impact Evaluation of the COVID-19 Prevention on Risk Factors of HIV and Sexually Transmitted Comorbidity
Official title: The Impact Evaluation of the COVID-19 Prevention Knowledge, Attitude, and Practice on Risk Factors of HIV and Sexually Transmitted Comorbidity: Application of Protection Motivation Theory
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: COVID-19 Pandemics
Human Immunodeficiency Virus
Keywords: Attitude
Behavior
Coronavirus disease 19 (COVID-19)
HIV high risk group
Knowledge
People living with HIV/AIDS (PLWHA)
Protection Motivation Theory (PMT)
Stigma
Lead sponsor: National Taiwan University
Sponsor class: OTHER
Collaborators: name: Ministry of Science and Technology, Taiwan
First posted: 2022-01-12
Enrollment: 2200
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: CASE_ONLY
Time perspective: CROSS_SECTIONAL
Sampling method: PROBABILITY_SAMPLE
Study population: Two study populations will be incruited in this research:

1. Those who had been diagnosed with HIV/AIDS.
2. Those who self-idenftified as HIV high risk group, such as having unsafe sex experience or injecting drug user.

Brief summary: This is a cross-sectional research. The Protection Motivation Theory (PMT) was applied as theoretical framework to analyze correlation of prevention knowledge, prevention intentions and anxiety, and prevention behavior of COVID-19 and HIV risk feature and behavior and stigma of people living with HIV/AIDS (PLWHA), and HIV high-risk groups. Purposive and snowball sampling will be applied to recruit participant who visit hospital, HIV/AIDS related institutions, and social media platforms. The investigators expect that the outcome could reveal the relationship of cognition and attitude of COVID-19 to HIV prevention and treatment.

Detailed description: The prevention strategies can effectively block the spread of Coronavirus disease (Coronavirus disease 19; COVID-19), and at the same time may indirectly reduce or increase the risk behaviors and factors of Human Immunodeficiency Virus (HIV) and sexually transmitted comorbidities. The main purpose of this research is to apply the Protection Motivation Theory (PMT) as the framework to analyze COVID-19 prevention knowledge, COVID-19 prevention intentions and anxiety level, and COVID-19 prevention behavior and HIV risk behavior and risk factors of people living with HIV/AIDS (PLWHA) and HIV high-risk groups. The cross-sectional research method was adopted, and the subjects included the northern, central, southern, and eastern regions of Taiwan.About 1100 PLWHA and 1100 high-risk groups will be recruited. The information of recruitment will be disseminated through the AIDS designated medical institutions and related institutions, and social media, Snowball recruitment of interviewees will also be used. After completing the online questionnaire, the structural equation modeling (SEM) will be applied to test the good of fit of the theory model and to explain the structural relationship between COVID-19 prevention knowledge, attitudes, behaviors and HIV risk factors. The relationship with the above variables and stigma also been discussed. In addition to verifying the theories proposition of PMT, the research results also contribute to the prevention and treatment of HIV high-risk groups, and provide important references for prevention strategies for susceptible groups during the epidemic of emerging infectious diseases in the future.

Eligibility criteria: Inclusion Criteria for HIV/AIDS participants:

1. Participants who diagnosed with HIV/AIDS.
2. Age over 18 years old.
3. Participants who can read and communicate.

Exclusion Criteria for HIV/AIDS participants:

1. Participants who can't read and communicate.

Inclusion Criteria for HIV high risk group:

1. Participants who have experienced unsafe sex, regardless of their gender orientation, such as those who describe themselves as men who have sex with men (MSM), heterosexuals, transgender, sex workers, etc.
2. Injecting Drug User(IDU)
3. Age over 18 years old.
4. Participants who can read and communicate.

Exclusion Criteria for HIV high risk group:

1. Participants who can't read and communicate.

Primary outcomes:
measure: COVID-19 prevention knowledge
timeFrame: Through study completion, an average of one and half year
measure: COVID-19 prevention intention and anxiety
timeFrame: Through study completion, an average of one and half year
measure: COVID-19 prevention behavior
timeFrame: Through study completion, an average of one and half year
measure: Stigma
timeFrame: Through study completion, an average of one and half year
measure: HIV risk factor and behavior
timeFrame: Through study completion, an average of one and half year
Secondary outcomes:
Other outcomes:
Locations:
city: Taipei
country: Taiwan
facility: School of Nursing of National Taiwan University
Study officials:
References: