Clinical trial NCT02095340: Effects of Maternal Interpretation Biases on Child Anxiety and Related Responses
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Anxiety Disorders
Lead sponsor: University of Houston
Sponsor class: OTHER
First posted: 2014-03-24
Enrollment: 210
Sex: ALL
Minimum age (years): 8
Maximum age (years): 12
Standard ages: CHILD
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: BASIC_SCIENCE

Brief summary: The purpose of this study is to expand our understanding of the intergenerational transmission of cognitive risk for childhood anxiety disorders by examining whether changes in maternal interpretations of situations result in changes in child interpretations and child anxiety.


Eligibility criteria: Inclusion Criteria:

* Children ages 8-12
* Children with primary diagnosis of anxiety disorder
* Mothers with clinical levels of anxiety symptoms on the Depression, Anxiety, and Stress Scales (DASS; Lovibond \& Lovibond, 1995)

Exclusion Criteria:

* Physical disability impairing ability to use a computer
* Intelligence Quotient \<80
* Reading comprehension and fluency composite \<75
* Concurrent primary diagnosis of any non-anxiety disorder
* Currently receiving psychological or pharmacological treatment for anxiety
* Danger to self/others
* Non-English speaking child/parent
* Maternal current involvement in cognitive-behavioral therapy
* Maternal changes in pharmacological treatment in the 12 weeks prior to enrollment.

Primary outcomes:
measure: Word Sentence Association Paradigm
timeFrame: Participants will be assessed, on average, within 20 minutes after the intervention.
measure: Maternal Anxious Behavior Coded by Independent Observers.
timeFrame: Immediately after the intervention, an average of 10 minutes.
Secondary outcomes:
Other outcomes:
Locations:
city: Houston
country: United States
facility: University of Houston
state: Texas
Study officials:
References:
citation: Raines EM, Viana AG, Trent ES, Conroy HE, Woodward EC, Zvolensky MJ, Storch EA. The explanatory role of anxiety sensitivity in the association between effortful control and child anxiety and depressive symptoms. Cogn Behav Ther. 2020 Nov;49(6):501-517. doi: 10.1080/16506073.2020.1790644. Epub 2020 Jul 21.
citation: Trent ES, Viana AG, Raines EM, Conroy HE, Storch EA, Zvolensky MJ. Interpretation biases and depressive symptoms among anxiety-disordered children: The role of individual differences in respiratory sinus arrhythmia. Dev Psychobiol. 2021 Mar;63(2):320-337. doi: 10.1002/dev.22002. Epub 2020 Jun 10.
citation: Trent ES, Viana AG, Raines EM, Woodward EC, Candelari AE, Storch EA, Zvolensky MJ. Interpretation Biases and Childhood Anxiety: The Moderating Role of Parasympathetic Nervous System Reactivity. J Abnorm Child Psychol. 2020 Mar;48(3):419-433. doi: 10.1007/s10802-019-00605-7.
citation: Raines EM, Viana AG, Trent ES, Woodward EC, Candelari AE, Zvolensky MJ, Storch EA. Effortful control, interpretation biases, and child anxiety symptom severity in a sample of children with anxiety disorders. J Anxiety Disord. 2019 Oct;67:102136. doi: 10.1016/j.janxdis.2019.102136. Epub 2019 Aug 27.