louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT04533256: Effects of Renal Replacement Therapy With Hemoadsoption in Patients With Sepsis
Official title: Effects of Renal Replacement Therapy With Hemoadsoption in Patients With Sepsis
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Sepsis
Keywords: organ failure
renal replacement therapy
hemoadsorption
Lead sponsor: Institutul Clinic Fundeni
Sponsor class: OTHER
First posted: 2020-08-31
Enrollment: 30
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Patients with sepsis or septic shock who require hemoadsorption in accordance with local guidelines. The decision of hemoadsorption is made by the attending physician prior to study inclusion.

Brief summary: Hemoadsorption has been demonstrated to improve clinical and paraclinical results in critically ill patients with sepsis and septic shock. The present study investigates the effects of three consecutive sessions of hemoadsorption, performed in accordance to the local protocol for treating patients with sepsis, on organ failure, severity scores and 30-days mortality. Paraclinical results and severity scores were obtained before and after the three consecutive sessions.


Eligibility criteria: Inclusion Criteria:

* patients with sepsis or septic shock who require hemoadsorption in accordance with local guidelines

Exclusion Criteria:

* unsigned informed consent
* duration of therapy under 12 hours
* death before the three consecutive sessions

Primary outcomes:
measure: 28-days mortality
timeFrame: 28 days after ICU admission
Secondary outcomes:
measure: severity score
timeFrame: 3 days
Other outcomes:
Locations:
city: Bucharest
country: Romania
facility: Fundeni Clinical Institute
Study officials:
affiliation: Fundeni Clinical Institute
name: Dana Tomescu, Prof
role: STUDY_CHAIR
References:
Clinical trial NCT04122456: DNA Repair Activity in the Skin of Day and Night Shift Workers
Official title: Pilot Study on DNA Repair Activity in the Skin of Day and Night Shift Workers
Study type: INTERVENTIONAL
Overall status: RECRUITING
Phase: NA
Conditions: Skin Cancer
Lead sponsor: Wright State University
Sponsor class: OTHER
First posted: 2019-10-10
Enrollment: 48
Sex: ALL
Minimum age (years): 18
Maximum age (years): 40
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: NON_RANDOMIZED
Intervention model: PARALLEL
Primary purpose: DIAGNOSTIC

Brief summary: The purpose of this study is to test how the skin of night shift workers responds to artificial sunlight (ultraviolet B radiation; UVB) at two different times of the day in comparison to normal day shift workers. After the skin biopsies are obtained, they will be brought to the laboratory to be exposed to UVB radiation and to measure UVB responses.


Eligibility criteria: Inclusion Criteria:

* Male/Female
* Fair skin (Fitzpatrick types I and II)
* Age 18 to 40
* Able to comprehend procedures/risks
* Primarily work and are awake during normal daylight hours (6 am to 6 pm), or primarily work and are awake during night shifts hours (between the hours of 6 pm and 6 am) or may work a mixture of these shifts over the past 3 months. Rotating shifts will be categorized based on the majority of hours worked on average during the last 3 months. Able to fill out a 3-month calendar of work schedule.

Exclusion Criteria:

* Known photosensitivity
* Currently on photosensitizing medications
* Diabetes Mellitus
* On any hormonal agents (e.g., birth control pills)
* History of abnormal scarring
* History of skin infections
* History of skin cancers
* History of sleep disorders such as sleep apnea or insomnia
* Known allergy to lidocaine local anesthetic
* Pregnancy or nursing
* Other serious health issues

Primary outcomes:
measure: Expression level of the DNA repair factor XPA at two times of the day in the skin of day and night shift workers.
timeFrame: After 1 hour incubation from ultraviolet B radiation exposure.
measure: Expression levels of core clock genes at two times of the day in the skin of day and night shift works.
timeFrame: After 1 hour incubation from ultraviolet B radiation exposure.
measure: Activity of the nucleotide excision repair (NER) system at two times of the day in day and night shift workers.
timeFrame: After 1 hour incubation from ultraviolet B radiation exposure.
measure: Activation of DNA damage kinase signaling pathways at two times of the day in the skin of day and night shift workers.
timeFrame: After 1 hour incubation from ultraviolet B radiation exposure.
Secondary outcomes:
Other outcomes:
Locations:
city: Fairborn
country: United States
facility: Wright State Physicians
state: Ohio
Study officials:
affiliation: Wright State University
name: Jeffrey B Travers, MD, PhD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT04591756: Effectiveness of Respiratory Protection During Simulated Resuscitation: a Prospective Cohort Study
Official title: Effectiveness of Respiratory Protection During Simulated Resuscitation: a Prospective Cohort Study
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Occupational Exposure
Keywords: Respirator
Cardiopulmonary resusitation
Lead sponsor: University of Virginia
Sponsor class: OTHER
First posted: 2020-10-19
Enrollment: 100
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: NON_RANDOMIZED
Intervention model: PARALLEL
Primary purpose: OTHER

Brief summary: The study hypothesizes that EHMRs with P100 filters will provide superior respiratory protection during simulated CPR compared to disposable N95 FFRs as measured by qualitative fit testing.

To this end, the study is a prospective observational cohort to evaluate the effectiveness of disposable FFRs and EHMR during simulated CPR. The primary endpoint will be subject report of detection of the testing agent during a 2 minute session of simulated chest compressions on a mannequin while wearing the respiratory protection that subjects routinely wear during the course of employment.


Eligibility criteria: Inclusion Criteria:

* Current use of respirator within last 7 days
* Completed fit test with respirator within last 2 years

Exclusion Criteria:

* Previous adverse reaction to fit testing or testing agent
* Development of any health problem that precludes use of a respirator since last occupational health evaluation

Primary outcomes:
measure: Subject Detection of Testing Agent
timeFrame: 2 minutes
Secondary outcomes:
measure: Time to detection of testing agent
timeFrame: 2 minutes
Other outcomes:
Locations:
city: Charlottesville
country: United States
facility: UVAHealth
state: Virginia
Study officials:
affiliation: University of Virginia
name: Andrew Barros, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT06179056: Anti-microbial Role of Non-antibiotic Agents Against Cutibacterium Acnes in Patients With Acne Vulgaris
Official title: Anti-microbial Role of Non-antibiotic Agents Against Cutibacterium Acnes in Patients With Acne Vulgaris
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Acne Vulgaris
Lead sponsor: Zagazig University
Sponsor class: OTHER_GOV
First posted: 2023-12-21
Enrollment: 48
Sex: ALL
Minimum age (years): 16
Maximum age (years): 40
Standard ages: CHILD
ADULT
Accepts healthy volunteers: yes
Observational model: CASE_ONLY
Time perspective: CROSS_SECTIONAL
Sampling method: PROBABILITY_SAMPLE
Study population: The study was carried out on 48 patients with acne vulgaris

Brief summary: * To evaluate and compare the anti-biofilm activity of Salicylic acid, Isotretinoin, and N-acetylcysteine against C. acne .
* To assess the possible role of Salicylic acid, Isotretinoin, and N-acetylcysteine in improving the susceptibility of C. acne for Azithromycin and Doxycycline.

Detailed description: The study was carried out on 24 patients with acne vulgaris. They were recruited from the outpatient clinic of the Dermatology and Venereology and Andrology Department, Zagazig University Hospitals, Egypt.

The degree of severity of lesions was determined by the global acne grading system (GAGS)

Microbiological samples were collected from all patients for:

1. Isolation of C. acnes
2. Antibiotic susceptibility testing for C. acnes isolates aganist the most commonly used antibiotics in treatment of acne(Azithromycin and Doxycycline) in the presence and absence of Salicylic acid, Isotretinoin, and N-acetylcysteine
3. Testing biofilm forming ability of C. acnes isolates in the presence and absence of Salicylic acid, Isotretinoin, and N-acetylcysteine

Eligibility criteria: Inclusion Criteria:

* Adult Patients.
* Patients of both sexes.
* Patients with acne vulgaris with different grades

Exclusion Criteria:

* Patients received topical or oral treatment within 6 weeks prior to microbiological sampling

Primary outcomes:
measure: inhibition of biofilm formation of c.acne after the use of Salicylic acid, Isotretinoin, and N-acetylcysteine
timeFrame: 6 month
measure: improvement of antibiotic sensitivity of c.acne after the use of Salicylic acid, Isotretinoin, and N-acetylcysteine
timeFrame: 6 month
Secondary outcomes:
Other outcomes:
Locations:
city: Zagazig
country: Egypt
facility: Reham Essam
state: Al Sharqia
Study officials:
affiliation: Zagazig University
name: Reham Essam
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT03940456: Prognostic Factors of Importance on Who Develops Chronic Low Back Pain
Official title: Prognostic Factors of Importance on Who Develops Chronic Low Back Pain: A Protocol Update for an Inception Cohort With Focus on Prognostic Factors With 54 Years of Follow up
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Low Back Pain
Life Style
Illness Perception
Keywords: Cohort
Low Back Pain
Illness perception
Life Style
Lead sponsor: Frederiksberg University Hospital
Sponsor class: OTHER
First posted: 2019-05-07
Enrollment: 607
Sex: ALL
Minimum age (years): 67
Maximum age (years): 69
Standard ages: OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Study population will comprise all available subjects who have been part of the Elsinore cohort since 1965

Brief summary: The incidence of low back pain (LBP) is increasing and prognostic factors for developing LBP are unclear. Based on questionnaires, different prognostic factors are being explored over time.

Detailed description: Despite massive efforts of trying to find predictors and prevention for LBP, it remains to be clarified, why some individuals develop severely disabling low back pain while others never experience noteworthy back pain. There is no evidence that numbers of chronically affected individuals have diminished; rather, the incidence of LBP has increased continuously over the last 20 years which is also reflected in rising numbers of lumbar surgical treatments. The prevalence and burden increase with age and prevention of LBP in an aging population seems more urgent than ever. As LBP is undoubtedly a multifaceted disorder that tends to fluctuate throughout life, there is a need for longitudinal research, exploring the effect of both life style and psychosocial factors on the development of chronic low back pain.

The aim of this study is to identify whether a history of low back pain during adolescence represents an increased risk of experiencing low back pain later in life.

Eligibility criteria: Inclusion Criteria:

This is an inception cohort based on pupils from schools in Elsinore. There are no formal inclusion criteria other tan being part of this cohort

Exclusion Criteria:

* No formal exclusion criteria but inability to understand/answer our questionnaire is per se an exclusion criteria

Primary outcomes:
measure: prevalence of LBP
timeFrame: measured once at study baseline
Secondary outcomes:
measure: Incidence of LBP
timeFrame: measured once at study baseline
measure: Brief illness perception questionnaire (IPQ-B)
timeFrame: measured once at study baseline
measure: EQ-5D (3 likert scale)
timeFrame: measured once at study baseline
Other outcomes:
Locations:
city: Copenhagen
country: Denmark
facility: The Parker Institute, Frederiksberg Hospital
Study officials:
References:
Clinical trial NCT03742856: A Multi-omics Study of Epithelial Ovarian Cancer
Official title: A Multi-omics Study on the Invasiveness of Epithelial Ovarian Cancer
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Epithelial Ovarian Cancer
Tumor Invasiveness
Whole Exome Sequencing
Transcriptomics
Metabolomics
Tumorigenesis
Lead sponsor: Peking Union Medical College Hospital
Sponsor class: OTHER
First posted: 2018-11-15
Enrollment: 80
Sex: FEMALE
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: CASE_CONTROL
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Patients confirmed primary epithelial ovarian cancer will be included for analysis.

Brief summary: This study aims to analyze the multi-omics results between epithelial ovarian cancer (EOC) patient with different FIGO stages and pathological subtypes. The multi-omics profiles include whole exome sequencing, analysis of transcriptomics and metabolomics. A comprehensive multi-omics will reveal the invasiveness and tumorigenesis of EOC.


Eligibility criteria: Inclusion Criteria:

* Confirmed primary epithelial ovarian cancer
* Signed an approved informed consents
* Feasible for biopsy

Exclusion Criteria:

* Not meeting all of the inclusion criteria

Primary outcomes:
measure: Frequencies of somatic driving mutations
timeFrame: Two years
Secondary outcomes:
measure: Frequencies of alteration of RNA expression
timeFrame: Two years
measure: Frequencies of alteration of protein expression and signal pathway
timeFrame: Two years
measure: Progression-free survival
timeFrame: Five years
Other outcomes:
Locations:
city: Beijing
country: China
facility: Lei Li
state: Beijing
Study officials:
affiliation: Peking Union Medical College Hospital
name: Lei Li, M.D.
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT05127356: Diagnostic Accuracy of DIAGNOdent Compared to ICDAS II
Official title: Diagnostic Accuracy of DIAGNOdent Compared to ICDAS II in Detection of Incipient White Spot Lesions: An In-vivo Evaluation
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Caries; Initial
Lead sponsor: Cairo University
Sponsor class: OTHER
First posted: 2021-11-19
Enrollment: 193
Sex: ALL
Minimum age (years): 18
Maximum age (years): 30
Standard ages: ADULT
Accepts healthy volunteers: yes
Observational model: OTHER
Time perspective: CROSS_SECTIONAL
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Patients with non cavitated incipient carious white spot lesions

Brief summary: There is a paradigm shift in conservative dentistry by substituting the surgical model with the medical model of treatment. Early detection of initial carious lesions will aid in clinical decision making during management ; either no care advised, preventive care advised or operative care advised. According to recent systematic reviews meticulous visual examination using ICDAS II presented a substantial level of reproducibility and accuracy for assessment of carious lesions and was considered the reference for clinical visual assessment . However, visual examination is subjective and is highly dependent on the dentist's skills and experience, with high specificity and low sensitivity. New devices have been developed to detect and quantify incipient demineralization. Besides visual detection systems, laser fluorescence assessment can be considered a suitable method. In vitro data suggested that the visual examination and fluorescence method have similar accuracy to detect initial carious lesions.

Detailed description: This study will be conducted to evaluate the diagnostic accuracy of laser fluorescence device (DIAGNOdent) compared to to visual examination (ICDAS II) in detection of incipient carious lesions for decision making during caries management

Eligibility criteria: Inclusion Criteria:

* Non cavitated white spot lesions.
* Patient compliance

Exclusion Criteria:

* Cavitated lesions.
* Medically compromised patients.
* Enrollment in another clinical trials.

Primary outcomes:
measure: Diagnostic accuracy
timeFrame: Immediate (cross-sectional)
Secondary outcomes:
Other outcomes:
Locations:
city: Cairo
country: Egypt
facility: Faculty of Dentistry, Cairo University
state: El Manial
Study officials:
affiliation: Lecturer, Conservative Dentistry Department, Faculty of Dentistry, Cairo University
name: Omar O Shaalan, PhD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT00624156: Expressive Writing and Adjustment to Metastatic Breast Cancer
Official title: Expressive Writing and Adjustment to Metastatic Breast Cancer
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Metastatic Breast Cancer
Keywords: Breast Cancer
Lead sponsor: Memorial Sloan Kettering Cancer Center
Sponsor class: OTHER
Collaborators: name: National Cancer Institute (NCI)
name: Indiana University
First posted: 2008-02-26
Enrollment: 98
Sex: FEMALE
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: MSKCC clinics

Brief summary: We are doing this study to see if writing about life experiences helps women adjust to breast cancer that has spread. We will compare two groups. One group will write about their breast cancer experience. The other will write about their daily activities. What we learn from this study may help us to find new ways to help women cope with breast cancer that has spread.


Eligibility criteria: Inclusion Criteria:

* Women with Stage IV breast cancer
* Receiving cancer care at Memorial Sloan-Kettering Cancer Center
* At least 18 years of age
* Can speak, read, and write in English
* In the judgment of consenting professionals able to provide informed consent
* Score of 4 or higher on the distress thermometer (established cutoff score for probable distress; see Jacobsen et al., 2005)

Exclusion Criteria:

* Significant psychiatric or cognitive impairment (dementia/delirium, retardation, psychosis) that in the judgment of the investigators will preclude providing informed consent and participating in the intervention
* Currently engaging in expressive writing (e.g., journal writing that involves expressing one's feelings) on a daily basis
* Currently participating in intervention trials with similar endpoints • Male

Primary outcomes:
measure: Determine the potential utility of expressive writing for enhancing existential well-being (i.e., increasing a sense of meaning and peace and reducing demoralization) among women with metastatic breast cancer.
timeFrame: conclusion of the study
Secondary outcomes:
measure: Determine the potential utility of expressive writing for reducing distress (i.e., depressive symptoms, anxiety, cancer-specific and general distress) among women with metastatic breast cancer.
timeFrame: conclusion of the study
Other outcomes:
Locations:
city: New York
country: United States
facility: Memorial Sloan Kettering Cancer Center
state: New York
Study officials:
affiliation: Memorial Sloan Kettering Cancer Center
name: Katherine DuHamel, PhD
role: PRINCIPAL_INVESTIGATOR
References:
citation: Mosher CE, Duhamel KN, Lam J, Dickler M, Li Y, Massie MJ, Norton L. Randomised trial of expressive writing for distressed metastatic breast cancer patients. Psychol Health. 2012;27(1):88-100. doi: 10.1080/08870446.2010.551212. Epub 2011 Jul 8.
Clinical trial NCT05145556: Teach Intubation by Novices in Anaesthesiology
Official title: Comparision of Direct Laryngoscopy and Video Laryngoscopy to Learn Successful Tracheal Intubation by Novices in Anaesthesiology
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Learning Problem
Larynx
Keywords: Tracheal Intubation, Learning Technique, Laryngoscope
Lead sponsor: Johannes Gutenberg University Mainz
Sponsor class: OTHER
First posted: 2021-12-06
Enrollment: 10
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: CROSSOVER
Intervention model description: Starting with 100 tracheal intubations with conventional tracheal intubation and videolaryngoscopy and after 100 intubations change the device for the next 100 intubations
Primary purpose: TREATMENT

Brief summary: Comparision of direct laryngoscopy and video laryngoscopy to learn successful tracheal intubation by novices in anaesthesiology

Detailed description: Video laryngoscopy has been recommended as an alternative during difficult conventional direct laryngoscopy using the Macintosh blade. However, successful visualisation of the larynx and tracheal intubation using some of the indirect laryngoscopes or video laryngoscopy requires hand-eye coordination. To best of our knowledge in the current literature there are no data how is the best educative way to learn successful tracheal intubation by novices in anaesthesiology.

Eligibility criteria: Inclusion Criteria:

* Age ≥ 18 Years
* capacity to consent
* Present written informed consent of the research participant

Exclusion Criteria:

* Age \<18 years
* Lack of consent
* inability to consent

Primary outcomes:
measure: First pass success rate
timeFrame: at intubation in 60 seconds
Secondary outcomes:
measure: Time to ventilation
timeFrame: at intubation in 120 seconds
measure: Cormack and Lehane Classification
timeFrame: at intubation in 120 seconds
measure: Overall success rate
timeFrame: at intubation in 120 seconds
measure: Subjective Training Process
timeFrame: at one month
Other outcomes:
Locations:
city: Mainz
country: Germany
facility: Department of Anesthesiology,Prof. C. Werner, Universitätsmedizin of the JG University
state: Rhineland-Palatinate
Study officials:
affiliation: University JG, Mainz
name: Marc MK Kriege, PD Dr
role: PRINCIPAL_INVESTIGATOR
References: