Clinical trial NCT06981585: Physical Impairments in Children With Chronic Renal Failure
Official title: Comparison of Muscle Strength, Physical Activity, Sleep Quality and Quality of Life Between Children With Chronic Kidney Failure and Healthy Children
Study type: OBSERVATIONAL
Overall status: NOT_YET_RECRUITING
Conditions: Chronic Kidney Failure
Chronic Kidney Diseases
Keywords: Chronic Kidney Failure
Muscle Strength
Physical Activity
Sleep Quality
Quality of Life
Lead sponsor: Izmir Democracy University
Sponsor class: OTHER
First posted: 2025-05-20
Enrollment: 25
Sex: ALL
Minimum age (years): 8
Maximum age (years): 18
Standard ages: CHILD
ADULT
Accepts healthy volunteers: yes
Observational model: CASE_CONTROL
Time perspective: CROSS_SECTIONAL
Sampling method: NON_PROBABILITY_SAMPLE
Study population: At least 25 patients with Chronic Kidney Failure will be included in the research group and at least 25 healthy individuals will be included in the control group.

Brief summary: When the literature is examined, it is seen that the extent to which cough strength, grip strength, physical activity level and quality of life levels are affected in children with chronic kidney failure compared to healthy children is not sufficiently clarified. For this reason, this study aimed to reveal impairments in grip strength, cough strength, physical activity, sleep quality or quality of life in children with chronic renal failure compared to healthy children.

Detailed description: The aim of this study is to compare children and adolescents with chronic kidney disease with healthy children and adolescents in terms of grip strength, cough strength, physical activity, sleep quality and quality of life. Participants will be evaluated for these parameters through clinical assessments, questionnaires and measurements. The aim of the study is to understand the health effects of chronic kidney disease and to provide the basis for improvements in the health management of these individuals.

Eligibility criteria: Inclusion Criteria: for Children and Adolescents with Chronic Kidney Failure

* Being between the ages of 8-18
* Being clinically stable for at least the last 3 weeks
* Having the necessary cooperation for the measurements
* Being willing to participate in the study

Inclusion Criteria for Healthy Children and Adolescents:

* Being between the ages of 8-18,
* Having the necessary cooperation for the measurements,
* Being willing to participate in the research

Exclusion Criteria: for Children and Adolescents with Chronic Kidney Failure

* Having any orthopedic, neurological, cardiovascular or psychological problems that may prevent measurements from being taken in the last 6 months
* Being a smoker or having quit
* Having had a kidney transplant.

Exclusion Criteria for Healthy Children and Adolescents:

* Having a history of any orthopedic, neurological, cardiovascular or psychological problems that may prevent measurements from being taken in the last 6 months
* Having any chronic disease
* Being a smoker or having quit smoking

Primary outcomes:
measure: Quality of life score
timeFrame: through study completion, an average of 1 year
Secondary outcomes:
measure: Cough Strength
timeFrame: through study completion, an average of 1 year
measure: Hand Grip Strength
timeFrame: through study completion, an average of 1 year
measure: Evaluation of Physical Activities
timeFrame: through study completion, an average of 1 year
measure: Evaluation of sleep quality
timeFrame: through study completion, an average of 1 year
Other outcomes:
Locations:
city: İzmir
country: Turkey
facility: İzmir Demokrasi Üniversitesi
Study officials:
affiliation: İzmir Demokrasi Üniversitesi
name: Gülşah Barğı
role: STUDY_DIRECTOR
affiliation: İzmir Demokrasi Üniversitesi
name: Hüseyin Kıran
role: PRINCIPAL_INVESTIGATOR
affiliation: SBÜ İTF DR. BEHÇET UZ ÇOCUK HASTALIKLARI VE CERRAHİSİ EĞİTİM VE ARAŞTIRMA HASTANESİ
name: Nida Dinçel
role: STUDY_DIRECTOR
References:
citation: Clark SL, Denburg MR, Furth SL. Physical activity and screen time in adolescents in the chronic kidney disease in children (CKiD) cohort. Pediatr Nephrol. 2016 May;31(5):801-8. doi: 10.1007/s00467-015-3287-z. Epub 2015 Dec 18.
citation: Taner S, Ekberli G, Gunes S. The Effect of Sleep Habits on Quality of Life in Pediatric Patients With Chronic Kidney Disease. Cureus. 2024 Jul 15;16(7):e64585. doi: 10.7759/cureus.64585. eCollection 2024 Jul.
citation: Darwish AH, Abdel-Nabi H. Sleep disorders in children with chronic kidney disease. Int J Pediatr Adolesc Med. 2016 Sep;3(3):112-118. doi: 10.1016/j.ijpam.2016.06.001. Epub 2016 Jun 29.