Clinical trial NCT06245707: the Effects of Different Treatment Schemes on Cognitive Function of Patients With Idiopathic Membranous Nephropathy
Official title: To Evaluate the Effects of Different Treatment Schemes on Cognitive Function of Patients With Idiopathic Membranous Nephropathy and Explore the Possible Mechanism by Using Functional Magnetic Resonance Imaging (fMRI)
Study type: INTERVENTIONAL
Overall status: RECRUITING
Phase: NA
Conditions: Mild Cognitive Impairment
Idiopathic Membranous Nephropathy
Lead sponsor: Beijing Friendship Hospital
Sponsor class: OTHER
First posted: 2024-02-07
Enrollment: 2
Sex: ALL
Minimum age (years): 18
Maximum age (years): 70
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: This study intends to apply prospective, open, single-center, randomized controlled study to evaluate the cognitive status of patients with Idiopathic membranous nephropathy and the influence of different treatment schemes on the cognitive status of patients with Idiopathic membranous nephropathy, and explore the possible pathophysiological mechanism by using brain magnetic resonance imaging technology.

Detailed description: Proteinuia is an independent risk factor for cognitive dysfunction and dementia. There is no relevant research on whether patients with Idiopathic membranous nephropathy with normal renal function are complicated with cognitive impairment. In the process of clinical diagnosis and treatment, it was observed that the cognitive function of patients with Idiopathic membranous nephropathy decreased significantly after treatment compared with that before treatment. However, there is no clinical study to confirm this phenomenon at present, and the causes of cognitive function damage are not clear. This study intends to apply prospective, open, single-center, randomized controlled study to evaluate the cognitive status of patients with Idiopathic membranous nephropathy and the influence of different treatment schemes on the cognitive status of patients with Idiopathic membranous nephropathy, and explore the possible pathophysiological mechanism by using brain magnetic resonance imaging technology, so as to fill the research gap of clinical cognitive status of Idiopathic membranous nephropathy and provide theoretical basis for better clinical treatment scheme selection and prevention of cognitive impairment.

Eligibility criteria: Inclusion Criteria:

* Patients with nephrotic syndrome and normal renal function.
* Patients with idiopathic membranous nephropathy diagnosed by pathology.
* not received hormone or other immunosuppressive treatment in the past six months.

Exclusion Criteria:

* Unable to treat patients with hormones and immunosuppression.
* Patients with definite intracranial diseases such as previous cerebral infarction and cerebral hemorrhage;
* Patients who have been diagnosed with cognitive decline or dementia in the past;
* Patients with claustrophobia or have other contraindications for magnetic resonance imaging, such as pacemakers and metal foreign bodies in the body.
* Pregnant and lactating women

Primary outcomes:
measure: The cognitive function of the two groups was evaluated and analyzed by the Chinese version of Montreal Cognitive Assessment Scale (MoCA)
timeFrame: enrollment, half a year after treatment and one year after treatment.
Secondary outcomes:
measure: Brain magnetic resonance high-resolution structural imaging was performed to observe the changes of brain structure
timeFrame: enrollment, half a year after treatment and one year after treatment.
Other outcomes:
Locations:
city: Beijing
country: China
facility: Beijing Friedship Hospital
state: Beijing
Study officials:
affiliation: Student
name: Jia Wang
role: PRINCIPAL_INVESTIGATOR
References: