Clinical trial NCT06707948: A Study on Different Treatments for Knee Osteoarthritis Caused by Damaged Roots of the Medial Meniscus.
Official title: Comparison of Different Treatment Strategies for Root Injury Behind the Medial Meniscus to Delay the Progression of Knee Osteoarthritis: a Prospective Cohort Study
Study type: OBSERVATIONAL
Overall status: NOT_YET_RECRUITING
Conditions: Osteoarthritis
Meniscus Lesion
Keywords: posterior meniscus root lesion;Osteoarthrotis
Lead sponsor: Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine
Sponsor class: OTHER
First posted: 2024-11-27
Enrollment: 69
Sex: ALL
Minimum age (years): 50
Maximum age (years): 65
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: Patients with posterior root injuries of the medial meniscus

Brief summary: Medial meniscus posterior root tears (MMPRT) account for 20% or more of all meniscus tears, but the diagnosis and treatment of this condition continues to plague the general population due to the complexity of the diagnosis and uncertainty of the treatment. Early as well as timely diagnosis and treatment is one of the effective ways to avoid accelerated knee degeneration. Based on this study, our team is going to conduct a clinical study on posterior medial meniscus tear, combining Magnetic Resonance Imaging(MRI) to dynamically assess the changes of meniscus and articular cartilage surface after the injury, and selecting a specific patient group to carry out different therapeutic interventions, which mainly include conservative treatment, partial meniscectomy, and meniscal repair, in order to clarify the effects of different treatment modalities on the articular cartilage after the posterior meniscus tear, and to help to delay the degeneration of knee joints. This is to clarify the effects of different treatment modalities on the articular cartilage after posterior medial meniscus tears and to provide appropriate advice for delaying the progression of osteoarthritis of the knee.


Eligibility criteria: Inclusion Criteria:

1. Clinical diagnosis of posterior root tear of the medial meniscus;
2. Patients with K-L classification ≤ grade II;
3. The age range of 50-65 years old;
4. International Cartilage Repair Society (ICRS) Modified Magnetic Resonance Imaging Grading System ≤ Grade 2;
5. International Cartilage Repair Society (ICRS) arthroscopic grading system ≤ grade 2;
6. Knee joint mobility ≥90°;
7. Inversion deformity ≤10°;
8. Must be able to complete follow-up MRI within 2 years after knee meniscus surgery;
9. Must be able to complete clinical data;

Exclusion Criteria:

1. Can not participate in this study;
2. Patients with concomitant meniscal injuries elsewhere;
3. knee joint infection disease;
4. Osteoporosis disease;
5. Patients with previous history of knee surgery;
6. Knee joint instability disease;
7. Severe KOA disease;
8. Can not cooperate with MRI detection;
9. Cannot tolerate the surgery;
10. Those who cannot tolerate the arthroscopic knee surgery;
11. Neuromuscular system pathology disease;

Primary outcomes:
measure: the incidence of KOA
timeFrame: 30th November 2024 -30th November 2027
Secondary outcomes:
measure: Articular cartilage T2-mapping value
timeFrame: 30th November 2024 -30th November 2027
Other outcomes:
measure: VAS (visual analogue scale)，VAS score
timeFrame: 30th November 2024 -30th November 2027
measure: Lysholm score
timeFrame: 30th November 2024 -30th November 2027
measure: HSS (Hospital for Special Surgery) Score
timeFrame: 30th November 2024 -30th November 2027
Locations:
Study officials:
References:
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