Clinical trial NCT04711928: The Association Between Sedentary Behaviour and Cardiometabolic Health in Trained Athletes
Official title: Do Trained Athletes Also Suffer From the Sedentary Behaviour Paradigm?: the Association Between Sedentary Behaviour and Cardiometabolic Health
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Cardiometabolic Health
Sedentary Behavior
Physical Activity
Athletes
Lead sponsor: Hasselt University
Sponsor class: OTHER
First posted: 2021-01-15
Enrollment: 60
Sex: ALL
Minimum age (years): 18
Maximum age (years): 45
Standard ages: ADULT
Observational model: CASE_ONLY
Time perspective: CROSS_SECTIONAL
Sampling method: PROBABILITY_SAMPLE
Study population: Active individuals with at least 4 training hours per week and between 18 and 45 years of age.

Brief summary: Physical inactivity is one of the major contributing factors for the development of chronic diseases and highly correlated with increased all-cause mortality. In the last decade an exponential growth in research concerned with the study of sedentary behaviour and the potential for detrimental effects on health have been published. In this field increasing evidence suggests that prolonged periods of sedentary time, independent of the amount of physical activity, also increases the risk for the development of several chronic conditions and all-cause mortality. Here, sedentary behaviour is defined as "any waking behaviour, characterized by a low energy expenditure (≤1.5 METs), while being in a sitting or reclining posture". Interestingly, the advised moderate-to-vigorous bouts of exercise recommended by the various guidelines cannot compensate the negative impact on health risks arising from prolonged periods of sitting. In other words, it seems that people compensate their total amount of physical activity after exercise training by decreasing their physical activity levels throughout the rest of the day. Here, it appears that frequent, even low-intensity interruptions of periods of sitting are required for good cardiometabolic health. Therefore, not only physical activity but also prolonged sitting should be targeted to optimize cardiometabolic health. Nevertheless, a recent harmonized meta-syntheses indicated that the association between self-reported sitting with all-cause and cardiovascular disease mortality are only partially independent of physical activity, but were particularly evident in those who undertake insufficient physical activity (\<150min/week). However, it is unclear whether high amounts of objectively measured physical activity attenuates or even eliminates the detrimental effects of prolonged sitting. In addition, it is still unclear whether high amounts of physical activity can preserve a healthy cardiometabolic risk profile, despite prolonged sitting. Therefore, in this study we want to investigate the association between sedentary behaviour, physical activity and cardiometabolic health in highly physically active adults.


Eligibility criteria: Inclusion Criteria:

* Active individuals with at least 4 training hours per week

Exclusion Criteria:

* pregnancy
* Any known contradiction for physical activity
* Systolic blood pressure \>160mmHg, diastolic blood pressure \>100mmHg
* More than 20 alcohol consumptions per week
* Participants diagnosed with any known chronic disease

Primary outcomes:
measure: Sedentary time (min/day)
timeFrame: day 1
Secondary outcomes:
measure: Moderate-to-vigorous physical activity time (min/day)
timeFrame: day 1
measure: Light physical activity time (min/day)
timeFrame: day 1
measure: Blood glucose concentration
timeFrame: day 1
measure: Blood insulin concentration
timeFrame: day1
measure: Blood total cholesterol concentration
timeFrame: day 1
measure: Blood triglyceride concentration
timeFrame: day 1
measure: Blood high density lipoprotein concentration
timeFrame: day 1
measure: Blood low density lipoprotein concentration
timeFrame: day 1
measure: Fat mass (kg)
timeFrame: day 1
measure: Lean mass (kg)
timeFrame: day 1
measure: Systolic blood pressure
timeFrame: day 1
measure: Diastolic blood pressure
timeFrame: day 1
measure: Maximal oxygen uptake
timeFrame: day 1
Other outcomes:
Locations:
city: Diepenbeek
country: Belgium
facility: Wouter Franssen
state: Limburg
Study officials:
References: