louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT05079685: HyFoSy Versus HSG as a Diagnostic Technique for Tubal Patency.
Official title: HyFoSy Versus HSG as a Diagnostic Technique for Tubal Patency: a Prospective Case-control Study.
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Tubal Patency
Sterility
Lead sponsor: Fundación Pública Andaluza para la gestión de la Investigación en Sevilla
Sponsor class: OTHER
First posted: 2021-10-15
Enrollment: 112
Sex: FEMALE
Minimum age (years): 18
Maximum age (years): 39
Standard ages: ADULT
Accepts healthy volunteers: no
Observational model: CASE_CONTROL
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: Women aged 18-39 years, with BMI \<30 and good ovarian reserve, undergoing study for primary sterility, subsidiary of conducting tubal patency studies to rule out pathology of the same and thus be able to perform Spousal or Donor IA.

Brief summary: Observational, single-center, prospective case-control study, in which each patient is his own control.

It focuses on the study of tubal patency and establishing the agreement of results between HyFoSy and HSG.

Detailed description: Observational, single-center, case-control study in which tubal pathology is studied in the context of a Basic Sterility Study.

The main objective of this study is to demonstrate the concordance of this new diagnostic test (HyFoSy) with HSG, which is the common technique to visualize tubal patency. Once demonstrated concordance, we also want to carry out a cost-effectiveness study and demonstrate through different scales the greater ease of the test, less time to perform and less pain for the patient.

It is a study in which the patients are women between 18-39 years old, undergoing study for primary sterility, with a BMI \<30, AMH\> 0.6 (good ovarian reserve).

Eligibility criteria: Inclusion Criteria:

* Women between 18-39 years, under study for primary sterility, with BMI \<30, AMH\> 0.6 (good ovarian reserve), subsidiaries of Conjugal or Donor IA, according to the 2019 SAS Reproduction Guide.

Exclusion Criteria:

* Women \<19 or\> 39 years old, BMI\> 30, secondary sterility, previous tubal sterilization, that is, the ART exclusion criteria according to the 2019 SAS Reproduction Guide.

Primary outcomes:
measure: Study of tubal patency and establish the concordance of results between HyFoSy and HSG.
timeFrame: Up to 48 weeks.
Secondary outcomes:
measure: Rate of occurrence of complications in the patients included in the study.
timeFrame: Up to 48 weeks.
measure: Time costs of performing HyFoSy versus HSG.
timeFrame: Up to 48 weeks.
Other outcomes:
Locations:
city: Sevilla
country: Spain
facility: Hospital Universitario Virgen macarena
Study officials:
affiliation: Hospital Universitario Virgen Macarena
name: Angela Morales Bueno
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT01140685: Analysis of Anti-inflammatory and Antioxidant Pathways in Lung Diseases by Haem Oxygenase-1 (HO-1) in Induced Sputum and Carbon Monoxide (CO) in Exhaled Air
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Lung Diseases
Keywords: mucus-stimulated (induced sputum)
lung disease (asthma, COPD, ILD and OLD)
HO-1 (heme oxigenase-1)
oxidative stress
CO (carbon monoxide)
The oxidative stress in lung diseases
Lead sponsor: Tel-Aviv Sourasky Medical Center
Sponsor class: OTHER_GOV
First posted: 2010-06-09
Enrollment: 70
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: CASE_CONTROL
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Fifty adult male and female patients who had been diagnosed with one or more of the four study diseases and referred for sputum induction to the Pulmonary Laboratory in the Tel-Aviv Sourasky Medical Center will be enrolled

Brief summary: This work will focus on the anti-inflammatory and antioxidant pathways in lung diseases by measuring HO-1 in induced sputum and CO in exhaled air in cases of four respiratory diseases, asthma, chronic obstructive pulmonary disease (COPD), occupational lung diseases (OLD) and interstitial lung disease (ILD).


Eligibility criteria: Inclusion Criteria:

* Male and female
* Ages \>/= 18 years
* Diagnosed with one or more lung diseases
* Referred for sputum induction to the Pulmonary Laboratory in the Tel-Aviv Sourasky Medical Center

Primary outcomes:
measure: exhaled CO levels
timeFrame: 2010-2011
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
affiliation: Tel Aviv Sorasky Medical Center
name: Elizabeth Fierman, PHD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT06947785: Effectiveness of Combined Neural Mobilization With Manual Myofascial Release for Sciatic Pain Relief
Official title: Effectiveness of Combined Neural Mobilization With Manual Myofascial Release for Sciatic Pain Relief
Study type: INTERVENTIONAL
Overall status: NOT_YET_RECRUITING
Phase: NA
Conditions: Sciatica
Keywords: Neural Mobilization
Myofascial Release
Sciatic Pain
Lead sponsor: Riphah International University
Sponsor class: OTHER
First posted: 2025-04-27
Enrollment: 48
Sex: ALL
Minimum age (years): 20
Maximum age (years): 40
Standard ages: ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: This study will address to evaluate and compare both Neural mobilization and Manual Myofascial Release of piriformis and Lumbar muscles in sciatic pain with the aim of evaluating and identifying the most effective intervention for managing this specific condition, and provide valuable insights into the effectiveness, mechanisms, and practical considerations associated with these interventions, ultimately contributing to evidence based and patient centered care.

Detailed description: MFR is a hands-on technique targeting fascial restrictions that may contribute to pain and reduced mobility. Barnes proposed that releasing fascial adhesions can improve circulation, reduce nerve compression, and enhance tissue flexibility. In a study by Ajimsha et al. , MFR was found to significantly reduce pain and improve physical function in patients with nonspecific low back pain. There is a lack of comparative research assessing the relative efficacy of neural mobilization andMFR in sciatic pain management. While both techniques are rooted in distinct mechanisms neural desensitization versus fascial release they may have overlapping benefits in improving mobility and reducing pain. This study addresses this research gap by directly comparing the two approaches in individuals with sciatic pain.

Eligibility criteria: Inclusion Criteria:

1. Clinically diagnosed unilateral sciatic pain for \>3 months.
2. Positive Straight Leg Raise (SLR).

Exclusion Criteria:

- Participants fall in this category would be excluded of the study.

1. Recent spinal surgery or trauma.
2. Neurological deficits or systemic conditions affecting the nervous system.
3. Any other red flags

Primary outcomes:
measure: Numerical pain rating scale
timeFrame: Four Weeks
measure: Universal Goniometer
timeFrame: Four Weeks
measure: Patient-Specific Functional Scale
timeFrame: Four Weeks
measure: SLR (Straight Leg Raise)
timeFrame: Four Weeks
Secondary outcomes:
Other outcomes:
Locations:
city: Chakdara
country: Pakistan
facility: Riphah International University, Malakand
state: KPK
Study officials:
affiliation: Riphah International University
name: Amnah Anum, MSPT
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT05009485: A Pre-post Intervention Study Evaluating Home-based Management of Patients With COPD or CAP
Official title: A Pre-post Intervention Study Evaluating Home-based Management of Patients With Chronic Obstructive Pulmonary Disease or Community Acquired Pneumonia
Study type: INTERVENTIONAL
Overall status: WITHDRAWN
Phase: NA
Conditions: Chronic Obstructive Pulmonary Disease
Community-acquired Pneumonia
Keywords: wearable
Current Health platform
30 day readmission
Lead sponsor: Current Health
Sponsor class: INDUSTRY
Collaborators: name: South Shore Hospital
First posted: 2021-08-17
Enrollment: 0
Sex: ALL
Minimum age (years): 21
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: TREATMENT

Brief summary: Risk of rehospitalization within 30 days of discharge is higher than 20% in patients with chronic obstructive pulmonary disease (COPD) and up to 20% for patients with community acquired pneumonia (CAP). This pre-post intervention study aims to quantify the impact of continuous remote patient monitoring (RPM) on rates of hospital readmission for patients presenting with CAP or exacerbation of COPD and compare the intervention group to historical controls that did not have access to the intervention. We hypothesize that an intervention combining remote patient monitoring with the remote clinical services and escalation pathways available at SSH (including the Mobile Integrated Health (MIH) program) will reduce hospital readmission within the 30 days following hospital discharge compared to standard of care in this population.


Eligibility criteria: Inclusion Criteria:

* 21 years or older
* confirmed diagnosis of moderate-severe COPD or community acquired pneumonia
* attendance at South Shore Hospital with an exacerbation of COPD / CAP
* fit for discharge to home

Exclusion Criteria:

* suspicion of COVID-19 or confirmed COVID-19 positive
* life-threatening exacerbation requiring invasive ventilation or prolonged stay in critical care (\> 24 hours)
* unable/unwilling to use Current Health
* bilateral axillary lymph node dissection
* persistent atrial fibrillation
* heavy tattooing on upper arms
* discharged to skilled nursing facility
* no access to home or mobile telephone

Primary outcomes:
measure: Number of participants with a hospital readmission
timeFrame: up to 30 days
Secondary outcomes:
measure: Time to service use
timeFrame: up to 30 days
measure: Rate of clinical visits
timeFrame: up to 30 days
measure: Length of Stay
timeFrame: up to 30 days
measure: Rate of Mortality
timeFrame: up to 30 days
measure: Rate of medication adherence
timeFrame: up to 30 days
measure: Progression of Disease
timeFrame: up to 30 days
Other outcomes:
measure: Patient Satisfaction as assessed by the Telehealth Usability Questionnaire
timeFrame: up to 30 days
Locations:
Study officials:
References:
Clinical trial NCT05292885: Mp-MRI in the Diagnosis of Liver Fibrosis After Liver Transplantation
Official title: Mp-MRI in the Diagnosis of Liver Fibrosis After Liver Transplantation
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Liver Fibrosis After Liver Transplantation
Multiparameter Magnetic Resonance Imaging
Lead sponsor: The Affiliated Hospital of Qingdao University
Sponsor class: OTHER
First posted: 2022-03-23
Enrollment: 40
Sex: ALL
Minimum age (years): 18
Maximum age (years): 85
Standard ages: ADULT
OLDER_ADULT
Observational model: CASE_ONLY
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: Patients with liver fibrosis after liver transplantation underwent percutaneous liver biopsy or FibroScan.

Brief summary: It is an open label observation clinical trial, all participants are liver transplant patients. The investigators deem to make a better criteria for assessing liver fibrosis after liver transplantation. The point of the clinical trial is to evaluate the efficacy of multiparameter MRI in the diagnosis of liver fibrosis after liver transplantation.

Detailed description: We collected patients aged 18 to 85 who had undergone liver transplantation. At the same time, all patients underwent liver biopsy or ultrasonic transient elastography after MRI. People who were allergic to gadolinium contrast agent, serious cardiopulmonary disease and contraindications to MRI were excluded.

Eligibility criteria: Inclusion Criteria:

* Subjects aged 18 -85 years
* Patients after liver transplantation
* Patients who are going to undergo liver biopsy or ultrasonic transient elastography
* Patients voluntarily joined the study and signed informed consent

Exclusion Criteria:

* Patients with tumor
* Patients who are allergic to gadolinium contrast agent
* Patients with contraindications to magnetic resonance imaging
* Patients with severe heart and lung diseases
* Patients who are not suitable for this study according to the researcher's judgment.

Primary outcomes:
measure: Mp-MRI in the Diagnosis of Liver Fibrosis After Liver Transplantation
timeFrame: 03.18.2022 to12.01.2022
Secondary outcomes:
Other outcomes:
Locations:
city: Qingdao
country: China
facility: The Affiliated Hospital of Qingdao University
state: Shandong
Study officials:
affiliation: The affiliated hostpital of Qingdao University
name: Guangjie Yang, PhD
role: STUDY_CHAIR
References:
Clinical trial NCT03202485: Comparison Between TICL and ICL+AK for High Myopic Astigmatism
Official title: Comparison Between Toric and Spherical Implantable Collamer Lens Combined With Astigmatic Keratotomy for High Myopic Astigmatism
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Astigmatism
High Myopia
Keywords: astigmatism
high myopia
phakic intraocular lens
astigmatic keratotomy
toric
Lead sponsor: Wenzhou Medical University
Sponsor class: OTHER
First posted: 2017-06-28
Enrollment: 62
Sex: ALL
Minimum age (years): 18
Maximum age (years): 40
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: NON_RANDOMIZED
Intervention model: PARALLEL
Intervention model description: Prospective comparative case series
Primary purpose: TREATMENT

Brief summary: To compare the outcomes of a toric Implantable Collamer Lens (ICL) and a spherical Implantable Collamer Lens combined with astigmatic keratotomy (AK) in the correction of high myopic astigmatism.


Eligibility criteria: Inclusion Criteria:

* age ranged from 18 to 40 years,
* myopia greater than -8.00 diopters (D), and refractive cylinder in the range of 1.50D to 5.50D,
* for the patients who were planned to undergo AK+ICL implantation, the axial difference between the corneal astigmatism and the manifest refractive astigmatism was less than 10 degree,
* a stable refractive error during the previous 2 years,
* anterior chamber depth more than 2.8 mm,
* endothelial cell density (ECD) more than 2500 cells/mm2, and
* scotopic pupillary diameter less than 7 mm.

Exclusion Criteria:

* subjects had significant irregular astigmatism, corneal pathological changes, glaucoma, ocular inflammation, or previous ocular trauma or surgery.

Primary outcomes:
measure: Uncorrected Visual Acuity (UCVA) at distance
timeFrame: 2 years after surgery
measure: astigmatism
timeFrame: 2 years after surgery
Secondary outcomes:
measure: Best Corrected Visual Acuity (BCVA) at distance
timeFrame: 2 years after surgery
measure: Spherical Equivalent (SE)
timeFrame: 2 years after surgery
measure: mean postoperative BCVA/mean preoperative BCVA
timeFrame: 2 years after surgery
measure: mean postoperative UCVA/mean preoperative BCVA
timeFrame: 2 years after surgery
Other outcomes:
Locations:
Study officials:
affiliation: Wenzhou Medical University
name: AYong Yu, MD.PhD.
role: PRINCIPAL_INVESTIGATOR
References:
citation: Zheng LY, Zhu SQ, Su YF, Zou HY, Wang QM, Yu AY. Comparison between toric and spherical phakic intraocular lenses combined with astigmatic keratotomy for high myopic astigmatism. Eye Vis (Lond). 2017 Aug 18;4:20. doi: 10.1186/s40662-017-0085-7. eCollection 2017.
Clinical trial NCT01827085: Time to Intubation (TTI) of Obese Patients. A Comparison Macintosh Laryngoscope and Stortz Video Laryngoscope
Official title: Time to Intubation in Obese Patients. A Comparison Between Macintosh Laryngoscope and Stortz Video Laryngoscope
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Obese
Lead sponsor: Örebro University, Sweden
Sponsor class: OTHER
First posted: 2013-04-09
Enrollment: 80
Sex: ALL
Minimum age (years): 18
Maximum age (years): 60
Standard ages: ADULT
Accepts healthy volunteers: no
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: In-patients from the University hospital of Orebro who will go through planned surgery

Brief summary: The purpose of the study is to investigate wether the use of the Stortz video laryngoscope will render in shorter time for the intubation of obese patients compared with the use of a conventional Macintosh laryngoscope.

Detailed description: Obese patients are prone to develop desaturation soon after initiation of anaesthesia compared to patients of normal body weight. It is therefore important to keep the time from when spontaneous breathing to when the airway is secured with a orotracheal tube as short as possible. We will therefore investigate if it is possible to shorten this time by using a Stortz videolaryngoscope.

Patients 18-60 years with ASA grade 1-3 and BMI \< 35 that turn up for planned surgery that demands the use of orotracheal tubing and controlled ventilation will be randomly and consecutively enrolled in either of two groups. Patients in both groups will be anaesthetised with the same combination of drugs using Propofol and Remifentanyl or Fentanyl for induction of sleep, combined with Rocuronium for muscle relaxation.

After the induction and relaxation the intubation will be facilitated using either of two laryngoscopes. In the first group a conventional Macintosh laryngoscope, and in the second group a Stortz videolaryngoscope will be used. The time to intubation is defined as the time from grabbing the laryngoscope to when the tube has been inserted and end-tidal carbon dioxide appears on the monitor. Our hypothesis is that we will be able to achieve a faster intubation with the use of videolaryngoscope.

Eligibility criteria: Inclusion Criteria:

* Age 18-60
* Obesity defined as BMI \> 35
* ASA 1-3

Exclusion Criteria:

-known or suspected difficult airway

Primary outcomes:
measure: Time to intubation seconds (s)
timeFrame: Up to 1 minute
Secondary outcomes:
measure: Presence and level of postoperational throat pain
timeFrame: 1 hour to 96 hours postoperative
measure: Ease of intubation
timeFrame: Two minutes
measure: Incidence of trauma in each group
timeFrame: Two minutes
measure: Number of attempts of intubation
timeFrame: Two minutes
Other outcomes:
Locations:
city: Örebro
country: Sweden
facility: Department of Anaethesia and Intensive Care, University Hospital Örebro
Study officials:
References:
Clinical trial NCT06267456: The Reliability of ULRT in Overhead Athletes and Its Relationship With Selected UEPT
Official title: The Reliability of Upper Extremity Rotation Test in Overhead Athletes and Its Relationship With Selected Upper Extremity Performance Tests
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Upper Limb Asymmetry
Keywords: Physical performance test
shoulder
assessment
Lead sponsor: Hacettepe University
Sponsor class: OTHER
First posted: 2024-02-20
Enrollment: 48
Sex: ALL
Minimum age (years): 18
Maximum age (years): 35
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: NON_RANDOMIZED
Intervention model: SEQUENTIAL
Intervention model description: handball, volleyball and basketball players 18-30 years Someone who has been participating in sports for at least three years and trains at least three times a week
Primary purpose: DIAGNOSTIC

Brief summary: Upper Extremity Rotation Test is a new test the evaluates 90-90 position, which is one of the requirements for overhead throwing. The aim of the study was to evaluate the reliability of the Upper Extremity Rotation Test in overhead athletes and the relationship between the Closed Chain Upper Extremity Stability Test and the Upper Quarter Y Balance Test.

Detailed description: Upper Extremity Rotation Test is a new test the evaluates 90-90 position, which is one of the requirements for overhead throwing. The aim of the study was to evaluate the reliability of the Upper Extremity Rotation Test in overhead athletes and the relationship between the Closed Kinetic Chain Upper Extremity Stability Test and the Upper Quarter Y Balance Test. Upper Extremity Rotation Test was found to be reliable in overhead athletes. Upper Extremity Rotation Test showed high reliability in overhead atheletes. There was no correlation between the Upper Exremity Rotation Test and the Upper Quarter Y Balance Test. A moderate corelation was found between the Upper Extremity Rotation Test and Closed Kinetic Chain Upper Extremity Stability Test.

Eligibility criteria: Inclusion Criteria:

* 18-30 years
* Continuing sports for at least three years for each group (volleyball, handball, baskeball)
* Athletes training at least three days per week.

Exclusion Criteria:

* Individuals experiencing difficulty understanding what the physiotherapist says.
* Having a history of orthopedic surgery within the last year

Primary outcomes:
measure: The reliability of Upper Extremity Rotation Test
timeFrame: January 2022
Secondary outcomes:
measure: The Relationship Assessment of the Upper Extremity Rotation Test
timeFrame: February 2022
Other outcomes:
Locations:
city: Kocaeli
country: Turkey
facility: Birgül Dıngırdan
state: İzmit
city: Ankara
country: Turkey
facility: Hacettepe University
Study officials:
affiliation: Sakarya Applied Sciences University
name: Birgül Dıngırdan, Master's
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT05163756: To Evaluate the Efficacy and Safety of DW1903 in Acute and Chronic Gastritis Patient
Official title: A Multi-center, Double-blind, Randomized, Parallel, Active-controlled, Non-inferiority, Phase III Clinical Trial to Evaluate the Efficacy and Safety of DW1903 in Patients With Gastritis
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE3
Conditions: Gastritis Acute
Gastritis Chronic
Lead sponsor: Daewon Pharmaceutical Co., Ltd.
Sponsor class: INDUSTRY
First posted: 2021-12-20
Enrollment: 332
Sex: ALL
Minimum age (years): 19
Maximum age (years): 75
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: A Multi-center, Double-blind, Randomized, Parallel, Active-controlled, Non-inferiority, Phase III Clinical Trial to Evaluate the Efficacy and Safety of DW1903 in Patients with Gastritis


Eligibility criteria: Inclusion Criteria:

* Patients who were diagnosed with acute or chronic gastritis in a gastroscopy performed within 7 days prior to administration of this trial.
* At least one or more erosions have been identified on gastroscopy.
* Patients who decided to voluntarily participate in this trial and agreed in writing.

Exclusion Criteria:

* Patients who can not undergo gastroscopy
* Peptic ulcer (except scarring) and reflux esophagitis
* Patients who have had gastric acid suppression surgery or stomach/esophagus surgery (except for simple perforation surgery and appendectomy)
* Patients with a history of gastrointestinal malignancies
* Zollinger-Ellison syndrome patients
* Patient with spontaneous coagulation disorder
* Patients with an allergic or hypersensitive response to a study drug
* Patients with a potential pregnancy.
* Patients who had clinically significant abnormalities in the screening test.
* Pregnant and lactating women
* Those currently taking other study drugs
* patients who were judged to be ineligible for the trial by the principle investigator and the person in charge.

Primary outcomes:
measure: The efficacy rate on gastroscopy
timeFrame: Week 0, Week2
Secondary outcomes:
measure: Cure rate on gastroscopy
timeFrame: Week 0, Week2
Other outcomes:
Locations:
city: Seoul
country: Korea, Republic of
facility: Korea University Ansan Hospital
Study officials:
References: