Clinical trial NCT02010385: Investigation of the Effects of Obesity Surgery on Appetitive Behaviour
Official title: Investigation of the Effects of Obesity Surgery on Appetitive Behaviour - Impact of Gut Hormones
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Roux-en-Y Bariatric Surgery
Keywords: RYGB
Bariatric surgery
Taste
Reward
Food behaviour
Gut hormones
Lead sponsor: University College Dublin
Sponsor class: OTHER
First posted: 2013-12-12
Enrollment: 30
Sex: ALL
Minimum age (years): 18
Maximum age (years): 65
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: CROSSOVER
Primary purpose: HEALTH_SERVICES_RESEARCH

Brief summary: Among all the existing ways to treat obesity (lifestyle, pharmacological), Roux-en-Y gastric bypass (RYGB) surgery is currently the most effective. It results in long term weight loss maintenance, significant remission of obesity-related comorbidities and decreased overall mortality. It also induces changes in gastrointestinal hormones responses, with an increase of anorexigenic hormones GLP-1, and PYY.

Although successful, the mechanisms for RYGB-induced weight loss are not completely understood. The RYGB does result in increased satiation, decreased calorie intake and decreased preferences for sweet and fatty foods. Previous work from our lab has shown using progressive ratio task (PRT) that RYGB specifically decreases the appetitive behaviour for sweet and fat stimuli but not for vegetables. The reasons for this change in appetitive behaviour after the surgery remain unknown. They may be triggered by changes in gut hormones, conditioned taste aversion (negative post-ingestive effects) or changes in serum bile acids levels.

This study aims to assess whether RGYB-induced gut hormone changes contribute to the decrease in appetitive behaviour for sweet and fatty foods observed after the surgery.

This is a double blind controlled study comparing the effect of blocking gut hormones with somatostatin analogue (octreotide) on the appetitive behaviour for sweet-fat candies will be carried out. Appetitive behaviour will be measured using the progressive ratio task.

The investigators hypothesize that blocking the gut hormones in obese patients with RYGB will increase their appetitive behaviour for sweet-fat candies.


Eligibility criteria: Inclusion Criteria:

* Gastric bypass surgery since at least 6 months

Exclusion Criteria:

* serious illness
* pregnancy or breast feeding
* more than three alcoholic drinks per day
* substance abuse
* psychiatric illness
* significant longstanding heart disease or heart intervention (for example, patients who have had heart attacks, have pacemakers or have had heart surgery)

Primary outcomes:
measure: Progressive ratio breakpoint
timeFrame: One hour
Secondary outcomes:
measure: Subjective ratings
timeFrame: One hour
measure: Gut hormones level
timeFrame: One hour
Other outcomes:
Locations:
city: Dublin
country: Ireland
facility: University College Dublin Clinical Research Centre
Study officials:
affiliation: UCD Conway institute
name: Carel le Roux, Pr, MD
role: PRINCIPAL_INVESTIGATOR
References:
citation: Miras AD, Jackson RN, Jackson SN, Goldstone AP, Olbers T, Hackenberg T, Spector AC, le Roux CW. Gastric bypass surgery for obesity decreases the reward value of a sweet-fat stimulus as assessed in a progressive ratio task. Am J Clin Nutr. 2012 Sep;96(3):467-73. doi: 10.3945/ajcn.112.036921. Epub 2012 Jul 25.