Clinical trial NCT03901196: Multi-elemental Imaging of Lung Tissues With LIBS (Laser-induced Breakdown Spectroscopy)
Official title: Multi-elemental Imaging of Lung Tissues With LIBS (Laser-induced Breakdown Spectroscopy) : a Feasibility Study
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Interstitial Lung Disease
Sarcoidosis
Idiopathic Pulmonary Fibrosis
Keywords: Laser Induced Breakdown Spectroscopy
Multi elemental imaging
Lead sponsor: University Hospital, Grenoble
Sponsor class: OTHER
First posted: 2019-04-03
Enrollment: 86
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: CASE_ONLY
Time perspective: RETROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Adults with Interstitial Lung Disease

Brief summary: Evaluate the feasibility of performing a multi-elemental imaging analysis of lung specimens from patients with ILDs, with an technology named LIBS (Laser Induced-Breakdown Spectroscopy)

Detailed description: There is a major health problem due to the environmental and occupational related exposures to mineral particles, metals, and dust. The impact on health is considerable in terms of prevalence, morbidity and healthcare costs. Pathologists rarely report the presence of a possible mineral or metal-related etiology in a specimen by lack of available and convenient technology. Therefore, several respiratory diseases are considered idiopathic.

Interstitial lung disease (ILD), also known as diffuse parenchymal lung disease (DPLD) is a group of lung diseases affecting the interstitium (the tissue and space around the air sacs of the lungs). In France, 15.000 new cases of ILD are diagnosed each year. ILD may be classified according to the cause. Idiopathic ILD are ILD of unknown causes. The most frequent idiopathic ILD are sarcoidosis and idiopathic pulmonary fibrosis (IPF).These two diseases are the core topic of the present study since they may relate to important mineral or metal exposure.

The overall goal of this MEDICO-LIBS study is to evaluate the feasibility of using a laser-induced breakdown spectroscopy (LIBS)-based instrument to image(ie, identify, localize and possibly quantify) metals within selected human specimens with ILDs.

Eligibility criteria: Inclusion Criteria:

* Patient with ILD
* Patient informed, and agreed to participate

Exclusion Criteria:

* Patient opposed to participating in the study.
* Patient without available specimen.
* Patient under legal protection

Primary outcomes:
measure: Generation of multi-elemental images in tissues with LIBS
timeFrame: Within a month after reception of the biopsy by the analytical laboratory
Secondary outcomes:
measure: Description of elemental distribution in the specimens
timeFrame: Within a month after reception of the biopsy by the analytical laboratory
measure: Interpretation of the elemental maps
timeFrame: Within a month after reception of the biopsy by the analytical laboratory
measure: Comparison of the elemental distributions with results of other mineralogical investigations
timeFrame: Within a month after reception of the biopsy by the analytical laboratory
Other outcomes:
Locations:
city: Grenoble
country: France
facility: Grenoble Alpes University Hospital
city: Lille
country: France
facility: CHRU de LILLE
city: Lyon
country: France
facility: CHU de Lyon HCL - GH Sud
city: Lyon
country: France
facility: Hôpital Louis Pradel
Study officials:
affiliation: Grenoble Alpes University Hospital
name: Benoit Busser, PharmD, PhD
role: PRINCIPAL_INVESTIGATOR
References:
citation: Busser B, Moncayo S, Trichard F, Bonneterre V, Pinel N, Pelascini F, Dugourd P, Coll JL, D'Incan M, Charles J, Motto-Ros V, Sancey L. Characterization of foreign materials in paraffin-embedded pathological specimens using in situ multi-elemental imaging with laser spectroscopy. Mod Pathol. 2018 Mar;31(3):378-384. doi: 10.1038/modpathol.2017.152. Epub 2017 Nov 17.
citation: Busser et al., Coord Chem Rev, 2018, 358, p70