Clinical trial NCT02003885: Effect of Desflurane on Cardiac Function During Cardiac Surgery: Tissue Doppler Imaging of Mitral Valve Annular Velocity
Official title: Effect of Desflurane on Left Ventricular Function in Remifentanil-based Anesthesia for Cardiac Surgery: Tissue Doppler Imaging of Mitral Valve Annular Velocity
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Valvular Heart Disease
Keywords: Desflurane, mitral annular velocity, tissue Doppler imaging
Lead sponsor: Konkuk University Medical Center
Sponsor class: OTHER
First posted: 2013-12-06
Enrollment: 14
Sex: ALL
Minimum age (years): 20
Maximum age (years): 65
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: DIAGNOSTIC

Brief summary: The purpose of this study is to determine desflurane's dose-dependent effect on left ventricular (LV) function in cardiac surgery. The change of tissue Doppler imaging (TDI) of lateral mitral valve annular velocity at three different desflurane concentrations would be analyzed by using intraoperative transesophageal echocardiography (TEE) in cardiac surgery patients

Detailed description: Tissue Doppler imaging (TDI ) of mitral annular velocity during the cardiac cycle has been introduced as a reliable method for analysis of systolic and diastolic LV ling-axix function , efficacy of diastolic TDI profile, including early early relaxation (E') and atrial contraction (A') and has been suggested to be useful in predicting the postoperative clinical outcomes and the impact of isoflurane on LV diastolic function.

Desflurane is widely used in cardiac surgery patients due to its beneficial effects , but many studies have shown that desflurane reduces myocardial contractility in a dose-dependent manner, and compromises left ventricular( LV) function We hypothesized that desflurane , even at a clinical dosage, would affects intraoperative LV systolic function in a dose-dependent manner and thus produce significant changes int the TDI profiles of mitral annular velocity.

So we planned to study the changes in TDI profiles of lateral mitral annular velocity at the clinical desflurane dosage during remifentanil based anesthesia for cardiac surgery

Eligibility criteria: Ages eligible for study : 20 years to 65 years Genders eligible for study : Both

Inclusion Criteria:

* Patients undergoing cardiac surgery

Exclusion Criteria:

* Low ejection fraction \<50% in preoperative transthoracic echocardiography
* Atrial fibrillation
* Pacemaker
* Pericardial and infiltrative myocardial disease
* Mitral annular calcification, surgical rings, prosthetic mitral valves
* Lateral left ventricular regional wall motion abnormality
* Esophageal spasm, stricture, laceration, perforation, and diverticulum
* Diaphragmatic hernia
* History of extensive radiation to mediastinum
* Upper gastrointestinal bleeding

Primary outcomes:
measure: Peak systolic mitral annular velocity (S')
timeFrame: after 10 min exposure to desflurane 0.5, 1.0 and 1.5 MAC
Secondary outcomes:
measure: diastolic mital annular veocities (E' and A'), ejection fraction (EF), Bispectral index
timeFrame: after 10 min exposure to desflurane 0.5, 1.0 and1.5 MAC
Other outcomes:
Locations:
city: Seoul
country: Korea, Republic of
facility: Konkuk University Medical Center
Study officials:
affiliation: Konkuk University Medical Center
name: Tae-Yop Kim, MD, PhD
role: PRINCIPAL_INVESTIGATOR
References: