Clinical trial NCT02947789: Predictive Model for Postoperative Mortality
Official title: Predictive Model for Postoperative Mortality in Adult Emergency Surgical Patients Under General Anesthesia
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Postoperative Complications
Lead sponsor: Khon Kaen University
Sponsor class: OTHER
First posted: 2016-10-28
Enrollment: 740
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: RETROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Adult patients undergoing emergency surgery

Brief summary: Surgery has risk of morbidity and mortality. Risk factors include: patient factors; surgical factors; and anesthetic factors. The risk is much higher in emergency cases. The study of relevant risk factors can lead to improvement in patient management and reduction in mortality.

Detailed description: Objective: To identify risk factors for postoperative mortality within 3 days in adult patients undergoing emergency surgery and construct a predictive model.

Methods: This will be a retrospective, exploratory and analytical study. All medical records of adult patients undergoing emergency surgery between January 2013 to December 2014 will be used to analyze for relevant risk factors using binary logistic regression analysis. A predictive model to predict postoperative morbidity within 3 days will be constructed.

Eligibility criteria: Inclusion Criteria:

* Emergency surgery
* Age =\> 18 years

Exclusion Criteria:

* Caesarean section
* Incomplete medical record

Primary outcomes:
measure: Postoperative mortality within 3 days
timeFrame: through study completion, an average of 1 week
Secondary outcomes:
Other outcomes:
Locations:
city: Khon Kaen
country: Thailand
facility: Faculty of Medicine, Khon Kaen University
Study officials:
affiliation: Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand
name: Sirirat Tribuddharat, MD
role: PRINCIPAL_INVESTIGATOR
References:
citation: Akinbami F, Askari R, Steinberg J, Panizales M, Rogers SO Jr. Factors affecting morbidity in emergency general surgery. Am J Surg. 2011 Apr;201(4):456-62. doi: 10.1016/j.amjsurg.2010.11.007.
citation: Fukuda N, Wada J, Niki M, Sugiyama Y, Mushiake H. Factors predicting mortality in emergency abdominal surgery in the elderly. World J Emerg Surg. 2012 May 11;7(1):12. doi: 10.1186/1749-7922-7-12.
citation: Ingraham AM, Cohen ME, Bilimoria KY, Raval MV, Ko CY, Nathens AB, Hall BL. Comparison of 30-day outcomes after emergency general surgery procedures: potential for targeted improvement. Surgery. 2010 Aug;148(2):217-38. doi: 10.1016/j.surg.2010.05.009.
citation: Matsuyama T, Iranami H, Fujii K, Inoue M, Nakagawa R, Kawashima K. Risk factors for postoperative mortality and morbidities in emergency surgeries. J Anesth. 2013 Dec;27(6):838-43. doi: 10.1007/s00540-013-1639-z. Epub 2013 May 23.
citation: Wilson I, Paul Barrett M, Sinha A, Chan S. Predictors of in-hospital mortality amongst octogenarians undergoing emergency general surgery: a retrospective cohort study. Int J Surg. 2014 Nov;12(11):1157-61. doi: 10.1016/j.ijsu.2014.08.404. Epub 2014 Sep 16.