Clinical trial NCT02080065: Incidence, Risk Factors, and Risk Model of Acute Kidney Injury After Liver Transplantation
Official title: Incidence, Risk Factors, and Risk Model of Acute Kidney Injury After Liver Transplantation
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Renal Function
Liver Transplantation
Keywords: risk factor
acute kidney injury
liver transplantation
postoperative renal function
Lead sponsor: Samsung Medical Center
Sponsor class: OTHER
First posted: 2014-03-06
Enrollment: 573
Sex: ALL
Minimum age (years): 20
Maximum age (years): 70
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: RETROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: patients who underwent living donor liver transplantation between 2010 and 2013

Brief summary: The incidence of acute kidney injury after liver transplantation has been reported to be 17 to 95 percent, but no definite treatment has been reported yet. Therefore, it is important to identify and prevent reversible risk factors for acute kidney injury after liver transplantation. Previous studies have reported several preoperative clinical risk factors, but preoperative medication and intraoperative colloid administration and hemodynamic parameters have not been evaluated. Therefore, we attempt to evaluate perioperative risk factors and develop simplified clinical risk scoring model.

Detailed description: Ischemia/reperfusion injury occurs during graft harvesting, cold storage, and surgical procedures in liver transplantation. Ischemia/reperfusion injury in liver graft results in major organ damage including kidney, lung and heart as well as graft dysfunction. Graft dysfunction and renal injury after liver transplantation are major clinical issues and are associated with prognosis and low survival rate. The incidence of acute kidney injury after liver transplantation has been reported to be 17 to 95 percent, but no definite treatment has been reported yet. Therefore, it is important to identify and prevent reversible risk factors for acute kidney injury after liver transplantation. Previous studies have reported several preoperative clinical risk factors, but perioperative medication, metabolic variables (albumin, glucose, uric acid), intraoperative colloid administration and hemodynamic parameters have not been evaluated. In addition, a neutrophil-lymphocyte ratio (NLR), which has been reported to be related to systemic inflammation and associated with prognosis of cardiac and cancer patients, might be related to the development of AKI after LDLT. Therefore, we attempt to evaluate these perioperative risk factors and develop simplified clinical risk scoring model.

Eligibility criteria: Inclusion Criteria:

* Patients who underwent living donor liver transplantation between 2010 and 2013 in Samsung Medical Center

Exclusion Criteria:

* Incomplete data regarding pre- and postoperative creatinine and estimated Glomerular Filtration Rate
* patient who underwent retransplantation

Primary outcomes:
measure: acute kidney injury as defined by RIFLE criteria
timeFrame: during 7 days after transplantation
Secondary outcomes:
measure: incidence of renal replacement therapy
timeFrame: during one month after transplantation
measure: incidence of acute rejection of graft
timeFrame: during one month after transplantation
measure: incidence of initial poor graft function
timeFrame: during one month after transplantation
measure: incidence of retransplantation
timeFrame: during one month after transplantation
Other outcomes:
measure: Mortality
timeFrame: during one month, six month, one year
Locations:
city: Seoul
country: Korea, Republic of
facility: Samsung Medical Center
Study officials:
References: