louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT03196752: Laryngeal Handshake for Identifying the Cricothyroid Membrane
Official title: Utility of the Laryngeal Handshake Method for Identifying the Cricothyroid Membrane
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Emergent Cricothyrodotomy
Keywords: cricothyroid membrane
Lead sponsor: Seoul National University Hospital
Sponsor class: OTHER
First posted: 2017-06-23
Enrollment: 123
Sex: ALL
Minimum age (years): 19
Maximum age (years): 80
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: OTHER

Brief summary: The cricothyroid membrane is the most common position that the invasive airway secure is performed, but it is not easy to identify the cricothyroid membrane by tactile perception. Although it is recommended to use the laryngeal handshake method for identifying the cricothyroid membrane in difficult airway society 2015 guidelines for management of unanticipated difficult intubation in adults, there is only suggestion without clinical data about how much the laryngeal handshake method improves the accuracy of identification of the cricothyroid membrane So we made the hypothesis that the cricothyroid membrane is identified more correctly when the laryngeal handshake method is used than when that method is not used. And we try to find out whether there is actual difference about identification of the cricothyroid membrane between using the laryngeal handshake method and not using that method. By identifying the difference between them, we are going to support the recommendation of guidelines and make the evidence for educating the doctors who have any possibility to perform the criocthyroidotomy to use the laryngeal handshake method skillfully in the 'cannot intubate, cannot oxygenate' situation.


Eligibility criteria: Inclusion Criteria:

* patients who underwent nose or ear surgery in Seoul National University Hospital and Seoul Metropolitan Government Seoul National University Boramae Medical Center

Exclusion Criteria:

* those whose ASA class was over 3, those who rejected to participate study or had impaired capacity to agree, those who was going to undergo neck surgery, those who had anatomical anomaly or skin lesion at neck, and those who were pregnant were excluded.

Primary outcomes:
measure: accuracy of cricothyroid membrane identification
timeFrame: Baseline
Secondary outcomes:
Other outcomes:
Locations:
city: Seoul
country: Korea, Republic of
facility: Seoul National University Hospital
state: Agree
city: Seoul
country: Korea, Republic of
facility: Boramae Medical Center
Study officials:
References:
citation: Oh H, Yoon S, Seo M, Oh E, Yoon H, Lee H, Lee J, Ryu HG. Utility of the laryngeal handshake method for identifying the cricothyroid membrane. Acta Anaesthesiol Scand. 2018 Oct;62(9):1223-1228. doi: 10.1111/aas.13169. Epub 2018 Jun 21.
Clinical trial NCT04704752: Swallowing Characteristics of Pediatric Patients With Eosinophilic Esophagitis
Official title: Clinical Characteristics of Swallowing in Pediatric Patients With Eosinophilic Esophagitis
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Eosinophilic Esophagitis
Lead sponsor: Gazi University
Sponsor class: OTHER
First posted: 2021-01-12
Enrollment: 52
Sex: ALL
Minimum age (years): 2
Maximum age (years): 17
Standard ages: CHILD
Observational model: CASE_ONLY
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Children and adolescents aged 2-17 years with a diagnosis of Eosinophilic Esophagitis

Brief summary: Eosinophilic Esophagitis (EoE) can affect patients all age group and clinical symptoms of the disease varies depending on the patient's ages. Infants and toddlers with EoE generally have food refusal, vomiting and poor weight gain. Older school-aged children and adolescents may have abdominal and chest pain, difficulty in swallowing (dysphagia) especially in solid foods. In the meantime, many children especially infants and toddlers, are not perceptive of their dysphagia, because they have the ability to compensate. Such as, avoiding certain textures or increases liquid intake in the meal.To date, to our knowledge, there is no study in the literature has investigated complex swallowing behaviour (including all phases), oral-motor evaluation and/or swallowing safety. Thus, the present study purposed to investigate (a) descriptive and clinical swallowing characteristics of children with EoE (b) the relation between disease characteristic and swallowing function.


Eligibility criteria: Inclusion Criteria:

* Children and adolescents aged 2-17 years with a diagnosis of Eosinophilic Esophagitis

Exclusion Criteria:

* Do not accommodate the study
* Do not want to attempt the study

Primary outcomes:
measure: Mastication and Observation Evaluation
timeFrame: 15 minutes
Secondary outcomes:
measure: Pediatric version of the Eating Assessment Tool-10
timeFrame: 10 minutes
Other outcomes:
Locations:
city: Ankara
country: Turkey
facility: Gazi University, Faculty of Health and Sciences, Department of Physiotherapy and Rehabilitation Recruiting Ankara, Turkey, 06500
Study officials:
affiliation: Gazi University
name: Bulent Elbasan, PhD
role: STUDY_CHAIR
References:
Clinical trial NCT06857552: The Effect of Ultrasound Guided Visual Biofeedback Performed by Midwifes on the Duration of the Active Second Stage of Labor
Official title: The Effect of Ultrasound Guided Visual Biofeedback Performed by Midwifes on the Duration of the Active Second Stage of Labor, a Randomized Controlled Trial
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Labor Stage, Second
Keywords: Prolonged second stage
Transperineal ultrasound
biofeedback
Lead sponsor: Kaplan Medical Center
Sponsor class: OTHER
First posted: 2025-03-04
Enrollment: 324
Sex: FEMALE
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: OTHER

Brief summary: The goal of this randomized controlled trial is to investigate whether using of coached sonographic pushing will decrease the length of the second stage of labor and the rate of operative deliveries.

Researchers will compare women who undergo the traditional coached pushing to women who undergo visual biofeedback coached pushing.


Eligibility criteria: Inclusion Criteria:

* Singleton pregnancy
* Nulliparous
* 37-42 weeks of gestation
* Under neuroaxial analgesia
* Reached the second stage of labor
* An estimated fetal weight between 2500-4000 grams

Exclusion Criteria:

* Women who arrived in active labor and delivered before being assessed by a physician.
* Women with contra-indications for vaginal birth

Primary outcomes:
measure: Length of the second stage of labor
timeFrame: At baseline
measure: Mode of delivery
timeFrame: At baseline
Secondary outcomes:
measure: Maternal outcomes
timeFrame: At baseline
measure: Neonatal Outcomes
timeFrame: At baseline
measure: Neonatal Outcomes
timeFrame: At baseline
Other outcomes:
Locations:
city: Rehovot
country: Israel
facility: Kaplan Medical Center
Study officials:
References:
citation: Bellussi F, Alcamisi L, Guizzardi G, Parma D, Pilu G. Traditionally vs sonographically coached pushing in second stage of labor: a pilot randomized controlled trial. Ultrasound Obstet Gynecol. 2018 Jul;52(1):87-90. doi: 10.1002/uog.19044. Epub 2018 May 30.
citation: Gilboa Y, Frenkel TI, Schlesinger Y, Rousseau S, Hamiel D, Achiron R, Perlman S. Visual biofeedback using transperineal ultrasound in second stage of labor. Ultrasound Obstet Gynecol. 2018 Jul;52(1):91-96. doi: 10.1002/uog.18962. Epub 2018 May 29.
Clinical trial NCT01044836: Safety and Pharmacokinetic Characteristics of HD203 in Healthy Male Volunteers
Official title: A Randomized, Double-blind, Single-dosing, Crossover Study to Compare the Safety and Pharmacokinetic Characteristics of HD203 25 mg With Those of Enbrel® Injection 25 mg After Subcutaneous Injection in Healthy Male Volunteers
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE1
Conditions: Healthy
Keywords: Healthy volunteer
Lead sponsor: Hanwha Chemical
Sponsor class: INDUSTRY
First posted: 2010-01-08
Enrollment: 42
Sex: MALE
Minimum age (years): 20
Maximum age (years): 40
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: CROSSOVER
Primary purpose: BASIC_SCIENCE

Brief summary: The purpose of this study is compare the safety and pharmacokinetic characteristics of HD203 with those of etanercept after subcutaneous injection in healthy male volunteers.


Eligibility criteria: Inclusion Criteria:

* 20 to 40 years of healthy volunteers

Primary outcomes:
measure: Etanercept levels in blood
timeFrame: 21 days
Secondary outcomes:
Other outcomes:
Locations:
city: Seoul
country: Korea, Republic of
facility: Seoul National University Hospital
Study officials:
affiliation: Seoul National University Hospital
name: Kyung-Sang Yu, M.D., Ph.D.
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT05711836: Role of HLA Genes and Innate Immunity in the Phenotypic Variability of COVID-19
Official title: Role of HLA Genes and Innate Immunity in the Phenotypic Variability of COVID-19 an Italian, Prospective, Multicenter Association Study
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: COVID-19
Lead sponsor: Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Sponsor class: OTHER
First posted: 2023-02-03
Enrollment: 720
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: CASE_CONTROL
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Subjects healed from severe forms of COVID19 and oligo/asymptomatic subjects as controls

Brief summary: Case-control, prospective retrospective association study of patients infected with SARS-CoV2 and cured by COVID19. Recruited patients were divided into two cohorts (cases: patients with respiratory failure that required hospitalization and ventilatory assistance. Controls: patients who had oligo-asymptomatic forms of COVID19). Patients' blood samples were collected on bibula paper, from which genomic DNA was extracted. Next-generation sequencing of HLA and innate immunity genes was performed on these samples. Genetic risk and protective variants were identified, based on the distribution of allele frequencies in the two cohorts. The aim of the study is to evaluate the role of genes of the HLA system and innate immunity in modulating the host response to SARS-CoV2 infection. The identification of these factors is essential from the perspective of public health (identifying individuals most in need of protection from infection as they are at higher risk of severe forms), basic research (characterization of molecular mechanisms of disease) and therapeutics (through knowledge of basic mechanisms, identify potential therapeutic targets and optimize the protective efficacy of vaccines).


Eligibility criteria: Inclusion Criteria:

* Oxygen saturation (SaO2) \<94% on room air; \<90% if known chronic hypoxic conditions or receiving chronic supplemental oxygen
* Respiratory rate \>24 breaths/min

Exclusion Criteria:

* Patients who still test positive for the presence of SARS-CoV-2 genome at the recruitment.
* Patients who cannot understand the meaning of the study and/or do not sign the informed consent form.

Primary outcomes:
measure: Severe COVID19
timeFrame: 52 weeks
Secondary outcomes:
Other outcomes:
Locations:
city: Roma
country: Italy
facility: Francesco Danilo Tiziano
state: Rm
Study officials:
References:
Clinical trial NCT03184636: Acute-On-Chronic Liver Failure in Zagazig University Hospitals
Official title: ACLF in Zagazig University Hospitals
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Acute-On-Chronic Liver Failure
Keywords: ACLF
SOFA
Zagazig university
Lead sponsor: Zagazig University
Sponsor class: OTHER_GOV
First posted: 2017-06-12
Enrollment: 300
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: All patients admitted to Gastroenterology and Hepatology Unit with the criteria of ACLF according to EASL-AASLD will be included in this study.

Brief summary: Rationale:

To identify the prevalence of Acute-on-chronic liver failure in Zagazig University Hospitals.

The question of the research:

How much the prevalence of Acute-on-chronic Liver Failure in Zagazig University Hospitals?

The aim of the work:

The aim of the study is to identify the presence of Acute-on-chronic Liver Failure in Zagazig University Hospitals

Objectives:

To estimate the prevalence of Acute-on-chronic Liver Failure in Zagazig University Hospitals.

Subjects and Methods:

I . Technical Design:

* Site of the study: Gastroenterology and Hepatology Unit- Zagazig University Hospitals
* Sample size: ''all patients admitted to Gastroenterology and Hepatology Unit with the criteria of ACLF according to EASL-AASLD from June 2017 to December 2017 were included in this study''.

II . OPERATIONAL DESIGN:

* Type of the study: a prospective study.
* Full medical history - taking.
* Full clinical examination.
* Laboratory investigations including Routine laboratory investigation " CBC, Liver functions test, kidney functions test and prothrombin time "

III. Administrative Design:

* Approvals obtained for performing the study from the official or governmental department.
* An ethical committee from the faculty of medicine and patients included in the study.

Results:

Collected data will be presented in tables and suitable graphs and analyzed according to standard statistical methods


Eligibility criteria: Inclusion Criteria:

* all patients admitted to Gastroenterology and Hepatology Unit with the criteria of ACLF according to EASL-AASLD will be included in this study.

Exclusion Criteria:

* no any exclusion criteria

Primary outcomes:
measure: improvement of the patients score according to SOFA score (AASLD and EASL guidelines)
timeFrame: 24 weeks from first recruiting
Secondary outcomes:
measure: death of the patient
timeFrame: 24 weeks from first recruiting
Other outcomes:
Locations:
city: Zagazig
country: Egypt
facility: Salem Mohamed
state: Sharqia
Study officials:
References:
Clinical trial NCT01934036: Obex, a Nutritional Supplement, in Overweight and Obese Spanish Women
Official title: Efficacy and Safety of Obex®, a Nutritional Supplement, in Overweight or Obese Women
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE2
PHASE3
Conditions: Obesity
Overweight
Keywords: Weight loss
Nutritional supplement
Waist
Body composition
Skinfolds
Lead sponsor: Catalysis SL
Sponsor class: INDUSTRY
First posted: 2013-09-04
Enrollment: 92
Sex: FEMALE
Minimum age (years): 35
Maximum age (years): 60
Standard ages: ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The aim of the study is to evaluate the effects of a dietary supplement (Obex®) on anthropometric and physiological variables in Spanish women between 35 and 60 years who are overweight or obese.

Detailed description: The nutritional supplement consists of natural plant extracts such as Caralluma fimbriata, Phaseolus vulgaris, Acai Berry and other antiobesity agents: ornithine, carnitine fumarate, essential fatty acids and certain amino acids, vitamins and minerals.

Eligibility criteria: Inclusion Criteria:

* Women aged between 35 and 60 years.
* Body Mass Index (BMI) greater than 27 kg/m² and lower than 35 kg/m²
* Ability to provide informed consent

Exclusion Criteria:

* Presence of any endocrine, hepatic, renal or cardiovascular disease.
* History of bariatric surgery
* Pregnancy or lactation
* Concomitant disease with reduced life expectancy
* Severe psychiatric conditions
* Drug dependence

Primary outcomes:
measure: To evaluate the effect of OBEX on skinfolds
timeFrame: Two months of treatment and three months after concluded the treatment
Secondary outcomes:
measure: To evaluate the effect of OBEX on the waist and hip circumferences
timeFrame: Two months of treatment and three months after concluded the treatment
measure: To evaluate the effect of Obex on the arm circumference.
timeFrame: Two months of treatment and three months after concluded the treatment
measure: To evaluate the effect of Obex on the percentage of body fat
timeFrame: Two months of treatment and three months after concluded the treatment
measure: To evaluate the effect of Obex on the muscular mass
timeFrame: Two months of treatments and three months after concluded the treatment
measure: To evaluate the effect of Obex on arterial blood pressures.
timeFrame: Two months of treatment and three months after concluded the treatment
measure: To evaluate the effect of Obex on fasting glucose and cholesterol levels
timeFrame: Two months of treatment and three months after concluded the treatment
Other outcomes:
Locations:
city: Ciudad Universitaria de Cantoblanco
country: Spain
facility: Universidad Autónoma de Madrid
state: Madrid
Study officials:
affiliation: Universidad Autonónoma de Madrid
name: Consuelo Prado, Ph.D.
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT05970536: Vital Pulp Therapy of Mature Permanent Teeth With Irreversible Pulpitis Using Bioceramic Material
Official title: The Effect of Two Different Contemporary Chelating Agents on Vital Pulp Therapy in Mature Permanent Teeth With Irreversible Pulpitis Using Bioceramic Material
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Vital Pulp Therapy
Lead sponsor: Sinai University
Sponsor class: OTHER
First posted: 2023-08-01
Enrollment: 40
Sex: ALL
Minimum age (years): 18
Maximum age (years): 50
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Intervention model description: Parallel double blinded.
Primary purpose: TREATMENT

Brief summary: This clinical trial is designed to study and compare the effect of two different types of chelating agents on the vital pulp therapy of mature permanent teeth with irreversible pulpitis using bioceramic material.

Detailed description: 1. The vital pulps exposed by caries process is treated by complete caries removal followed by full pulpotomy.
2. After hemostasis, application of apple vinegar and EDTA 17% will be used followed by MTA application. finally teeth will be restored with resin composite restoration.

Eligibility criteria: Inclusion Criteria:

* Presence of at least one tooth with carious pulp exposure and irreversible pulpitis.
* Cooperative behavior with no medical problem.
* Absence of tooth mobility , tenderness on percussion.
* History of pain with cold and sweets.
* Radiographically, no internal or external resorption, no periapical or furcation radiolucency and no widening of the periodontal membrane space.

Exclusion Criteria:

* Teeth with pulp necrosis.
* Presence of sinus tract.
* Teeth with open apices.
* Pregnant women.
* History of intolerance of non- steroidal anti inflammatory drugs.
* Tenderness to palpation of adjacent soft tissues

Primary outcomes:
measure: Success rate of vital pulp therapy of mature permanent teeth with irreversible pulpitis using bioceramic material.
timeFrame: one year
measure: The Pulp vitality
timeFrame: one year
Secondary outcomes:
measure: Radiographic success
timeFrame: one year
Other outcomes:
Locations:
city: Cairo
country: Egypt
facility: Mona Rizk Abo El Wafa Ahmed
Study officials:
affiliation: Faculty of Dentistry, Sinai University.
name: Mona R Abo El Wafa Ahmed, PhD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT02645136: The Effects of Pilates in Muscle Strength of the Pelvic Floor as Treatment of Post Prostatectomy Urinary Incontinence
Official title: The Effects of Pilates Method in Muscle Strength of the Pelvic Floor as Treatment of Post Prostatectomy Urinary Incontinence: : a Randomized Control Trial
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Prostate Cancer
Urinary Incontinence
Lead sponsor: Universidade Estadual de Londrina
Sponsor class: OTHER
First posted: 2016-01-01
Enrollment: 115
Sex: MALE
Minimum age (years): 50
Maximum age (years): 75
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The purpose of this study is to compare the efficacy between a Pilates exercise program and a Pelvic Floor Muscle Training (PFMT) protocol combined with anal electrical stimulation (AES) in muscular pressure strength of the pelvic floor as conservative treatment of urinary incontinence after prostatectomy.

Detailed description: This randomized clinical trial includes 115 individuals with urinary incontinence one month after radical prostatectomy. One physiotherapist, with experience in urogynecology, was responsible for all the assessments. muscular pressure strength of the pelvic floor, 24-hour pad test and the International Consultation on Incontinence Questionnaire - Short Form (ICIQ-SF) were the variables evaluated.

The subjects were allocated in one of three treatment groups (G1: Pilates; G2: anal electrical stimulation combined with pelvic floor muscle training and G3: Control Group).

Eligibility criteria: Inclusion Criteria:

* Volunteers between 50 and 75 years old;
* Submitted to radical prostatectomy;
* With complaints of urinary incontinence;
* That completed one month of surgery;

Exclusion Criteria:

* History of incontinence;
* Transurethral resection of the prostate;
* Diagnosis of neurological or cognitive impairment;
* Subjects who were unable to attend treatment sessions, due to distance or physical limitations.

Primary outcomes:
measure: improves muscle strength of the pelvic floor at 3 months
timeFrame: baseline and 3 months
Secondary outcomes:
measure: Change in the International Consultation of Urinary Incontinence- Short Form questionnaire at 3 months
timeFrame: baseline and 3 months
measure: Change in Pad test 24 hours at 3 months
timeFrame: baseline and 3 months
Other outcomes:
Locations:
Study officials:
References:
citation: Gomes CS, Pedriali FR, Urbano MR, Moreira EH, Averbeck MA, Almeida SHM. The effects of Pilates method on pelvic floor muscle strength in patients with post-prostatectomy urinary incontinence: A randomized clinical trial. Neurourol Urodyn. 2018 Jan;37(1):346-353. doi: 10.1002/nau.23300. Epub 2017 May 2.
Clinical trial NCT00647036: Microbial Invasion During Parenteral Nutrition in Surgical Infants Receiving Glutamine
Official title: Microbial Invasion During Parenteral Nutrition in Surgical Infants Receiving Glutamine.
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE4
Conditions: Surgical Infants Requiring Total Parenteral Nutrition
Keywords: Parenteral nutrition, Infants, Dipeotiven, Microbial invasion
Lead sponsor: Institute of Child Health
Sponsor class: OTHER
First posted: 2008-03-31
Enrollment: 60
Sex: ALL
Maximum age (years): 3
Standard ages: CHILD
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: SINGLE_GROUP
Primary purpose: OTHER

Brief summary: We hypothesise that the addition of glutamine supplementation to both parenteral nutrition and enteral feeds in surgical newborn infants leads to a reduction in bacterial invasion.


Eligibility criteria: Inclusion Criteria:

* Infants who have undergone surgical procedures for congenital anomalies or
* Intestinal inflammation who require total parenteral nutrition.

Exclusion Criteria:

-

Primary outcomes:
measure: Evidence of microbial invasion
timeFrame: 5 days
Secondary outcomes:
Other outcomes:
Locations:
city: London
country: United Kingdom
facility: Institute of Child Health, 30 Guilford Street
Study officials:
References:
citation: Bishay M, Simchowitz V, Harris K, Macdonald S, De Coppi P, Klein N, Eaton S, Pierro A; MIGS Trial Group. The Effect of Glutamine Supplementation on Microbial Invasion in Surgical Infants Requiring Parenteral Nutrition: Results of a Randomized Controlled Trial. JPEN J Parenter Enteral Nutr. 2020 Jan;44(1):80-91. doi: 10.1002/jpen.1700. Epub 2019 Sep 9.