Clinical trial NCT03723044: Multistability: Perception is Inspired by Noise
Official title: Multistability: Perception is Inspired by Noise
Study type: INTERVENTIONAL
Overall status: RECRUITING
Phase: NA
Conditions: No Conditions
Keywords: Multistable Perception
Micro eye movement
Electroencephalography
Lead sponsor: University Hospital, Grenoble
Sponsor class: OTHER
Collaborators: name: GIPSA-LAB
First posted: 2018-10-29
Enrollment: 80
Sex: ALL
Minimum age (years): 18
Maximum age (years): 55
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: BASIC_SCIENCE

Brief summary: Some stimuli, such as sinusoidal networks in motion, or the best known, Necker's cube, are simple visual stimulations generating interpretations of unstable and oscillatory shapes or movements, mutually exclusive. Currently, the explanatory models of these perception phenomena are based on adaptation and learning mechanisms as well as the importance of noise in the perceptual and decision-making system. Often noise is a harmful component, but it can also be a facilitator in perceptual systems: the investigator's eye is always in motion, it is the micro-movements during eye fixation (phase of eye stability). In particular, the role of micro-eye movements has been identified in perceptual systems, and it will be necessary here to relate these micro-movements to the perceptive tilts facing multisable stimuli. However, how to access the perceptive states is a real question, since it has been shown that the participant's transfer of his perceptual state by means of a motor response can alter the very state of the percept. This is why the EEG activity will be analyzed to learn to discriminate the different percepts over time, without disruption of the participant's perceptual exploration endogenous activity.

Detailed description: Each participant will benefit from a medical interview before inclusion to eliminate the contraindications to this study. The maximum duration of the individual participation of each subject in this study is 5 hours in two sessions. Each session lasts 2h30. Both sessions are spaced a maximum of 14 days apart. Each session includes EEG headset placement and oculometer calibration (20 min), followed by recording EEG and eye tracking activity during a visual cognitive task where the participant will be presented with multi-stable visual stimuli to watch. for one or two minutes after the tests. By repeating the essays and the conditions of presentation, each session will be organized in six blocks of 20 minutes each, interspersed with a break.

Eligibility criteria: Inclusion Criteria:

* Signed informed consent
* Medical examination carried out before the participation in the research
* Age between 18 and 55 years
* Minimum level of studies
* Obligation to join the social security system
* normal or corrected vision normal

Exclusion Criteria:

* Subject included in another clinical and / or therapeutic experimentation in progress
* Major vision disorder
* Past or current neurological or neuropsychiatric pathologies
* History of cranial trauma with loss of consciousness.
* Medication treatments likely to modulate brain activity: benzodiazepine, antidepressants, neuroleptics, lithium, etc.
* Diabetes, cardiac pathology, immunodeficiency.
* Medication treatments likely to modulate the activity of the cardiovascular system.
* History of abuse or recent ingestion of alcohol, hard drugs or doping products.
* Consumption of more than 15 cigarettes per day
* Subject deprived of liberty by a judicial or administrative decision (L1121-6 CSP)
* Major subject subject to a legal protection measure or unable to express their consent (L1121-8 CSP)
* Pregnant, parturient and nursing mothers (L1121-5)

Primary outcomes:
measure: Micro-eye movement
timeFrame: along the complete experiment (2 hours) per session and per participant.
measure: Electroencephalography
timeFrame: along the complete experiment (2 hours) per session and per participant.
Secondary outcomes:
Other outcomes:
Locations:
city: Grenoble
country: France
facility: CHU Grenoble-Alpes
Study officials:
References: