Clinical trial NCT05403489: Comparison of the Results of Bronchoalveolar Lavage Culture and Endotracheal Aspirate Culture in Intubated Critically Ill COVID-19 Patients
Official title: Comparison of the Results of Bronchoalveolar Lavage Culture and Endotracheal Aspirate Culture in Intubated Critically Ill COVID-19 Patients
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Bronchoalveolar Lavage
COVID-19 Pneumonia
Critical Illness
Lead sponsor: Hisar Intercontinental Hospital
Sponsor class: OTHER
First posted: 2022-06-03
Enrollment: 67
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: OTHER
Time perspective: RETROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: The patients who were intubated due to COVID 19 in our reanimation unit between January 2021 and December 2021 and underwent BAL or ETA analysis were retrospectively scanned from the hospital information management system and patient files.

Brief summary: Introduction: Secondary pneumonia is frequently seen in COVID-19 cases followed up intubated, and high mortality rates can be observed. Isolation of the agent with bronchoalveolar lavage (BAL) culture or endotracheal aspirate (ETA) culture may increase the success of treatment. This study aimed to retrospectively analyze the results of BAL and ETA cultures in intubated COVID-19 cases.

Methods: We routinely apply BAL culture with bronchoscopy or ETA culture within the first 48 hours after intubating. We retrospectively screened cases who underwent BAL and ETA. They were divided into two groups: Group B and E. Evaluated parameters were compared in both groups.

Results: Demographic data and blood test results were similar in both groups. Intensive care unit (ICU) and intubation durations, and culture positivity were statistically significantly higher in Group B. Although not statistically significant, the mortality rate was higher in Group E. The most growth microorganisms were Candida species.

Conclusion: Mortality rates were consistent with the literature. Since the microorganism isolation rate is higher with BAL and antimicrobial treatment is applied more effectively; early deaths were prevented and stay periods were prolonged. In contrast, these durations were shorter in the ETA group due to higher mortality. In intubated COVID-19 cases, a more effective treatment process can be carried out by clearing the airway with fiberoptic bronchoscopy and by specifically planning the treatment according to the BAL culture. This may have a positive effect on prognosis and mortality.


Eligibility criteria: Inclusion Criteria:

* Intubated COVID-19 patients
* Above 18 years old patients

Exclusion Criteria:

* Non COVID-19 patients
* Non intubated COVID-19 patients
* Below 18 years old patients

Primary outcomes:
measure: Culture positivity
timeFrame: 1 years
measure: Length of stay in intensive care unit
timeFrame: 1 years
measure: Duration of intubation
timeFrame: 1 years
measure: Mortality
timeFrame: 1 years
Secondary outcomes:
measure: Microorganism
timeFrame: 1 years
Other outcomes:
Locations:
city: Istanbul
country: Turkey
facility: Hisar Intercontinental Hospital
Study officials:
affiliation: Hisar Intercontinental Hospital
name: Hasan Huseyin Kilic
role: PRINCIPAL_INVESTIGATOR
References: