Clinical trial NCT04182529: Photo Neuro-Modulation Therapy to Adults
Official title: Photo Neuro-Modulation Therapy to Middle Aged and Older Adults With Mild Memory Problem
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Photo Neuro-Modulation Therapy, Mild Cognitive Impairment
Lead sponsor: Chinese University of Hong Kong
Sponsor class: OTHER
First posted: 2019-12-02
Enrollment: 40
Sex: ALL
Minimum age (years): 40
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: It is well-documented that mild cognitive impairment (MCI) is associated frontal lobe dysfunction and executive dysfunction. In addition, many studies reported high level of MCI symptoms among the elderly and the trend is increasing in Hong Kong. Based upon the link between MCI and frontal and executive function problems, it is conceivable that elderly who exhibits high levels of memory problems would exhibit frontal and executive function problems. To our knowledge, there is still a lack of effective treatment or therapy for MCI, it is important to investigate effective intervention that can efficiently improve the cognitive ability of MCI patients or patients with mild memory problems. The objective of the present study is to compare individuals with mild memory problems after the Photo neuro-modulation Therapy (PNMT) and those who do not. 40 middle aged and older adults were recruited from the subject database of the Neuropsychology Laboratory of The Chinese University of Hong Kong. Participants were divided randomly and equally into treatment group, as well as the placebo group. Several computerized executive function tests will be used before and after the treatment under the recording of near-infrared spectroscopy (NIRS), which estimates level of frontal activation. It is hypothesized that compared to participants without PNMT, those with PNMT will have a better performance in the executive function tasks and exhibit a higher frontal activation. The cognitive and neurophysiological results would provide evidences on the possibility of PNMT in treating individuals with mild memory problems, as well as with other mental disorders.


Eligibility criteria: Inclusion Criteria:

* 40 middle age and older adults with aged 40 or above who have subjective memory complaints

Exclusion Criteria:

* A history of head injury, or any neurological/psychiatric disorders, and dementia will be excluded. In addition, a score higher than 7 on the short form of the Chinese Geriatric Depression Scale (CGDS-SF; Lee, Chiu, Kwok, \& Leung, 1993)

Primary outcomes:
measure: N-Back Test (cognitive test battery)
timeFrame: through study completion, an average of 2 year
measure: Category Fluency Test
timeFrame: through study completion, an average of 2 year
measure: The Hong Kong List Learning Test
timeFrame: through study completion, an average of 2 year
measure: The Chinese Version of the Mattis Dementia Rating Scale
timeFrame: through study completion, an average of 2 year
measure: NIRS Recording
timeFrame: through study completion, an average of 2 year
measure: EEG Recordings
timeFrame: through study completion, an average of 2 year
measure: EEG Recordings
timeFrame: through study completion, an average of 2 year
Secondary outcomes:
Other outcomes:
Locations:
city: Hong Kong
country: Hong Kong
facility: Neuropsychology Laboratory, Department of Psychology, The Chinese University of Hong Kong
Study officials:
References: