Clinical trial NCT03393728: Heart Rate Variability and Hyperthyroidism: Evaluation of the Short-term Effects of Propanolol
Official title: Short Term Effects of Propanolol on Heart Rate Variability of Hyperthyroidism
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE4
Conditions: Hyperthyroidism
Keywords: hyperthyroidism
heart rate variability
propanolol
Africa
Lead sponsor: Yaounde Central Hospital
Sponsor class: OTHER_GOV
First posted: 2018-01-08
Enrollment: 10
Sex: ALL
Minimum age (years): 18
Maximum age (years): 70
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Intervention model description: Open label Before and After design
Primary purpose: TREATMENT

Brief summary: Objective: The aim of our study was to evaluate the short term effects of Propanolol on heart rate variability in patients with hyperthyroidism.

Design: In ten patients newly diagnosed as having hyperthyroidism and naïve of all treatment specific for hyperthyroidism, we evaluated the short term effects of Propanolol on heart rate variability (HRV).

Methods: We measured heart rate variability by power spectral analysis during 2 hours of rest and during Ewing's tests before and after the administration of Propanolol 40mg/12 hours orally for 72 hours.

Detailed description: Objective: The aim of our study was to evaluate the short term effects of Propanolol on heart rate variability in patients with hyperthyroidism.

Design: In ten patients newly diagnosed as having hyperthyroidism and naïve of all treatment specific for hyperthyroidism, we evaluated the short term effects of Propanolol on heart rate variability (HRV).

Methods: We measured heart rate variability by power spectral analysis during 2 hours of rest and during Ewing's tests before and after the administration of Propanolol 40mg/12 hours orally for 72 hours. Other outcomes included mean heart rate, mean R-R interval during 2-hour rest.

The study questions the systematic adjunction of Propanolol early in the treatment of hyperthyroidism.

Eligibility criteria: Inclusion Criteria:

* consenting patients referred to or diagnosed at the National Centre of Obesity of the Yaounde Central Hospital as having hyperthyroidism
* naïve of all treatment specific for hyperthyroidism.
* aged 18-70 years

Exclusion Criteria:

* Patients already under a specific treatment for hyperthyroidism
* Patients taking beta blockers or any other cardiospecific treatment
* Patients presenting complications including acute thyrotoxic crisis, or symptomatic cardiac failure
* Contraindications to the prescription of beta blockers

Primary outcomes:
measure: Heart rate variability
timeFrame: 72 hours
Secondary outcomes:
measure: Heart rate
timeFrame: 72 hours
Other outcomes:
Locations:
Study officials:
affiliation: Yaounde Central Hospital and University of Yaounde 1
name: Jean Claude N Mbanya, MD, PhD
role: STUDY_CHAIR
affiliation: Hôpital Central de Yaoundé et Université de Yaoundé 1
name: Eugène Sobngwi
role: PRINCIPAL_INVESTIGATOR
References:
citation: Tankeu AT, Azabji-Kenfack M, Nganou CN, Ngassam E, Kuate-Mfeukeu L, Mba C, Dehayem MY, Mbanya JC, Sobngwi E. Effect of propranolol on heart rate variability in hyperthyroidism. BMC Res Notes. 2018 Feb 22;11(1):151. doi: 10.1186/s13104-018-3224-x.