Clinical trial NCT06240052: Use Electroencephalogram to Study Neural Dynamics of Fear Conditioning and Avoidance Learning Circuit in Humans
Official title: Use Electroencephalogram to Study Neural Dynamics of Fear Conditioning and Avoidance Learning Circuit in Humans
Study type: INTERVENTIONAL
Overall status: RECRUITING
Phase: NA
Conditions: Neural Dynamics of the Acquisition and Retention of Fear Learning and Active Avoidance Learning
Keywords: Fear Learning
Active Avoidance
Electroencephalogram (EEG)
Lead sponsor: The University of Texas Health Science Center, Houston
Sponsor class: OTHER
First posted: 2024-02-02
Enrollment: 150
Sex: ALL
Minimum age (years): 18
Maximum age (years): 70
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: BASIC_SCIENCE

Brief summary: The purpose of this study is to examine which event-related potentials (ERPs) and event-related oscillations (EROs) are associated with fear conditioning, avoidance learning, and memory recall for fear and avoidance, where are the source generators of the observed scalp EEG activity, the impact of fear and avoidance learning on the decision to avoid or not to avoid conditioned stimuli , to examine the large-scale functional connectivity across distributed brain regions across experimental phases, and to examine whether spontaneous EEG data during resting-state correlate with the EEG measures during experimental tasks.


Eligibility criteria: Inclusion Criteria:

* Willing and able to provide informed consent.

Exclusion Criteria:

* History of neurologic disease
* History of seizure or significant head trauma/loss of consciousness
* Significant serious psychiatric diagnosis
* Significant suicidal ideation or behaviors
* High risk of adverse emotional or behavioral reaction, and/or an inability to understand study procedures or the informed consent process, based on investigator/clinician clinical evaluation

Primary outcomes:
measure: Skin Conductance Response (SCR) during the image familiarization phase (viewing phase)
timeFrame: During the image familiarization/viewing phase (about 15 minutes total)
measure: Skin Conductance Response (SCR) during the fear conditioning phase
timeFrame: During the fear conditioning phase (about 18 minutes total)
measure: Skin Conductance Response (SCR) during the avoidance learning phase
timeFrame: During the avoidance learning phase (about 18 minutes total)
measure: Skin Conductance Response (SCR) during the memory recall phase
timeFrame: During the memory recall phase (about 18 minutes total)
measure: Skin Conductance Response (SCR) during resting state
timeFrame: Immediately Before the Viewing Phase on day 1
measure: Skin Conductance Response (SCR) during resting state
timeFrame: Immediately After the Viewing Phase (day 1 about 15 minutes after start of viewing phase)
measure: Skin Conductance Response (SCR) during resting state
timeFrame: Immediately Before the fear conditioning Phase (day 1 about 20 minutes after start of viewing phase)
measure: Skin Conductance Response (SCR) during resting state
timeFrame: Immediately After the fear conditioning Phase (day 1 about 38 minutes after start of viewing phase)
measure: Skin Conductance Response (SCR) during resting state
timeFrame: Immediately Before the avoidance learning phase (day 1 about 43 minutes after start of viewing phase)
measure: Skin Conductance Response (SCR) during resting state
timeFrame: Immediately after the avoidance learning phase (day 1 about 61 minutes after start of viewing phase)
measure: Skin Conductance Response (SCR) during resting state
timeFrame: Immediately Before the memory recall phase on day 2 (about 1 day after start of viewing phase)
measure: Skin Conductance Response (SCR) during resting state
timeFrame: Immediately after the memory recall phase (day 2 about 1 day 18 minutes after start of memory recall phase)
measure: Number of participants who had higher event-related potentials (ERPs) in response to CS+ categories relative to CS- categories, as assessed by electroencephalogram (EEG) during the image familiarization phase (viewing phase)
timeFrame: During the image familiarization/viewing phase (about 15 minutes total)
measure: Number of participants who had higher event-related potentials (ERPs) in response to CS+ categories relative to CS- categories, as assessed by electroencephalogram (EEG) during the fear conditioning phase
timeFrame: During the image familiarization/viewing phase (about 15 minutes total)
measure: Number of participants who had higher event-related potentials (ERPs) in response to CS+ categories relative to CS- categories, as assessed by electroencephalogram (EEG) during the avoidance learning phase
timeFrame: During the avoidance learning phase (about 18 minutes total)
measure: Number of participants who had higher event-related potentials (ERPs) in response to CS+ categories relative to CS- categories, as assessed by electroencephalogram (EEG) during the memory recall phase
timeFrame: During the memory recall phase (about 18 minutes total)
measure: Spontaneous electrical activity in the brain during the resting state as assessed by electroencephalogram (EEG)
timeFrame: Immediately Before the Viewing Phase on day 1
measure: Spontaneous electrical activity in the brain during the resting state as assessed by electroencephalogram (EEG)
timeFrame: Immediately After the Viewing Phase (day 1 about 15 minutes after start of viewing phase)
measure: Spontaneous electrical activity in the brain during the resting state as assessed by electroencephalogram (EEG)
timeFrame: Immediately Before the fear conditioning Phase (day 1 about 20 minutes after start of viewing phase)
measure: Spontaneous electrical activity in the brain during the resting state as assessed by electroencephalogram (EEG)
timeFrame: Immediately After the fear conditioning Phase (day 1 about 38 minutes after start of viewing phase)
measure: Spontaneous electrical activity in the brain during the resting state as assessed by electroencephalogram (EEG)
timeFrame: Immediately Before the avoidance learning phase (day 1 about 43 minutes after start of viewing phase)
measure: Spontaneous electrical activity in the brain during the resting state as assessed by electroencephalogram (EEG)
timeFrame: Immediately after the avoidance learning phase (day 1 about 61 minutes after start of viewing phase)
measure: Spontaneous electrical activity in the brain during the resting state as assessed by electroencephalogram (EEG)
timeFrame: Immediately Before the memory recall phase on day 2 (about 1 day after start of viewing phase
measure: Spontaneous electrical activity in the brain during the resting state as assessed by electroencephalogram (EEG)
timeFrame: Immediately after the memory recall phase (day 2 about 1 day 18 minutes after start of memory recall phase).
measure: Number of times a participant pressed the button to avoid shock in response to an object category during the avoidance learning phase
timeFrame: During the avoidance learning phase (about 18 minutes total)
measure: Number of times a participant pressed the button in response to an object category during the memory recall phase
timeFrame: During the memory recall phase (about 18 minutes total)
Secondary outcomes:
Other outcomes:
Locations:
city: Houston
country: United States
facility: The University of Texas Health Science Center at Houston
state: Texas
Study officials:
affiliation: The University of Texas Health Science Center, Houston
name: Mohammed Milad, PhD
role: PRINCIPAL_INVESTIGATOR
References: