Clinical trial NCT06489509: Distribution of Pulmonary Ventilation in Lateral Decubitus of Healthy Adults Under Non-Invasive Mechanical Ventilation
Official title: Distribution of Pulmonary Ventilation in Lateral Decubitus of Healthy Adults Under Non-Invasive Mechanical Ventilation Supply
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Noninvasive Ventilation
Patient Positioning
Keywords: impedance tomography
distribution of ventilation
lateral decubitus
Noninvasive Ventilation
Lead sponsor: Attikon Hospital
Sponsor class: OTHER
First posted: 2024-07-08
Enrollment: 10
Sex: ALL
Minimum age (years): 18
Maximum age (years): 35
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: CROSSOVER
Intervention model description: The regional distribution of pulmonary ventilation was measured in the supine, right, and left lateral positions while alternating the sides to ensure randomization.
Primary purpose: SUPPORTIVE_CARE

Brief summary: The aim was to investigate via impedance tomography apparatus the distribution of pulmonary ventilation at a lateral position at different Continuous Positive Airway Pressure levels (0, 5, 10 cm Η2Ο) in healthy subjects.

Detailed description: In lateral decubitus, the largest percentage of pulmonary ventilation of non-sedated subjects is distributed mainly in the dependent lung. The aim It was to investigate via impedance tomography apparatus the distribution of pulmonary ventilation at a lateral position at different Continuous Positive Airway Pressure levels (0, 5, 10 cm Η2Ο) in healthy subjects. The volunteers were noninvasively ventilated in both lateral positions and supine positions at the beginning and end of the process. It is concluded that implementing Non-Invasive Ventilation in the lateral body position resulted in increased ventilation of the dependent lung. In contrast, the respective ventilation of the non-dependent lung was further decreased.

Eligibility criteria: Inclusion Criteria:

• Healthy Volunteers

Exclusion Criteria:

* Chronic respiratory disease
* BMI\>40
* Smoking history

Primary outcomes:
measure: The percentage change in pulmonary ventilation
timeFrame: Up to 3 minutes
Secondary outcomes:
Other outcomes:
Locations:
city: Athens
country: Greece
facility: Attikon University Hospital
state: Attica
city: Athens
country: Greece
facility: Grigoriadis Konstantinos
state: Attica
Study officials:
affiliation: PT, Attikon University Hospital
name: Konstantinos Grigoriadis, Dr
role: PRINCIPAL_INVESTIGATOR
affiliation: PT, Attikon University Hospital
name: Anna Grigoriadou, MSc
role: STUDY_DIRECTOR
affiliation: MD, Attikon University Hospital
name: Frantzeska Frantzeskaki
role: STUDY_DIRECTOR
affiliation: PT, Attikon University Hospital
name: Ioannis Efstathiou
role: STUDY_DIRECTOR
affiliation: Professor, Attikon University Hospital
name: Iraklis Tsangaris
role: STUDY_CHAIR
References:
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citation: Sharma JP, Salhotra R, Kumar S, Tyagi A, Sethi AK. Noninvasive lung recruitment maneuver prevents reintubation and reduces ICU stay. Lung India. 2016 Jan-Feb;33(1):99-101. doi: 10.4103/0970-2113.173070. No abstract available.
citation: Hurewitz AN, Susskind H, Harold WH. Obesity alters regional ventilation in lateral decubitus position. J Appl Physiol (1985). 1985 Sep;59(3):774-83. doi: 10.1152/jappl.1985.59.3.774.
citation: Lobo B, Hermosa C, Abella A, Gordo F. Electrical impedance tomography. Ann Transl Med. 2018 Jan;6(2):26. doi: 10.21037/atm.2017.12.06.
citation: Miura MC, Ribeiro de Carvalho CR, Yamada da Silveira LT, de Moraes Regenga M, Petri Damiani L, Fu C. The effects of recruitment maneuver during noninvasive ventilation after coronary bypass grafting: A randomized trial. J Thorac Cardiovasc Surg. 2018 Dec;156(6):2170-2177.e1. doi: 10.1016/j.jtcvs.2018.05.004. Epub 2018 May 28.
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