Clinical trial NCT04252378: Ultrasound-guided Deep and Superficial Serratus Anterior Plane Block
Official title: Comparison of Intraoperative Opioid Consumption, Emergence Time and Hemodynamic Stability Between Ultrasound-guided Deep and Superficial Serratus Anterior Plane Block During Video-assisted Thoracoscopic Lobectomy
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Pain Management
Thoracotomy
Lead sponsor: Kyungpook National University Hospital
Sponsor class: OTHER
First posted: 2020-02-05
Enrollment: 56
Sex: ALL
Minimum age (years): 20
Maximum age (years): 75
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: This study evaluates the difference of deep and superficial serratus anterior plane block on intraoperative opioid consumption, emergence time and hemodynamic stability in patients undergoing video-assisted thoracic surgery.

Detailed description: Thoracotomy is known as one of the most painful surgery. Thus, there is a development to reduce surgical stress in terms of operation technique, which is video-assisted thoracoscopic surgery. Although it has reduced postoperative pain and complications compared with thoracotomy, VATS is still quite painful operation. Serratus plane block is a novel technique which provide analgesic effect for lateral chest wall by blocking lateral branch of intercostal nerve. Two methods were proposed to target the top and bottom of the serratus anterior muscle. However, the difference of deep and superficial serratus anterior plane block during intraoperative period has not yet been studied.

In this study, therefore, the investigators decided to assess the difference of deep and superficial serratus anterior plane block on intraoperative opioid consumption, emergence time and hemodynamic stability in patients undergoing video-assisted thoracic surgery.

Eligibility criteria: Inclusion Criteria:

* a) American Society of Anesthesiologists (ASA) physical status 1 or 2
* b) age 20-75 years
* c) elective three port Video-assisted thoracoscopic surgery (VATS) lobectomy.

Exclusion Criteria:

* a) a history of drug allergy for opioids or local anesthetics
* b) local infection at the injection site and systemic infection
* c) coagulopathy
* d) difficulty in understanding the study protocol
* e) refusal to participate

Primary outcomes:
measure: Intraoperative remifentanil consumption
timeFrame: through study completion, an average of 1 year
Secondary outcomes:
measure: Emergence time
timeFrame: through study completion, an average of 1 year
measure: Systolic blood pressure
timeFrame: through study completion, an average of 1 year
measure: Heart rate (HR) Heart rate
timeFrame: through study completion, an average of 1 year
measure: Dose of rescue drugs used to control blood pressure and HR
timeFrame: through study completion, an average of 1 year
measure: Postoperative pain: numeric rating scale
timeFrame: 30 minutes later operation
Other outcomes:
Locations:
city: Daegu
country: Korea, Republic of
facility: Kyungpook national university hospital
Study officials:
affiliation: Kyungpook National University Hospital
name: Saeyoung Kim
role: PRINCIPAL_INVESTIGATOR
References: