louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT06292715: Microwave Ablation With Splenic Artery Occlusion for Secondary Hypersplenism
Official title: A Single-Arm Clinical Study Evaluating Microwave Ablation of the Spleen Combined With Splenic Artery Occlusion for Secondary Hypersplenism Treatment
Study type: INTERVENTIONAL
Overall status: RECRUITING
Phase: NA
Conditions: Secondary Hypersplenism
Lead sponsor: Tianjin Medical University Cancer Institute and Hospital
Sponsor class: OTHER
First posted: 2024-03-05
Enrollment: 35
Sex: ALL
Minimum age (years): 18
Maximum age (years): 65
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: TREATMENT

Brief summary: This study assesses the effectiveness of microwave ablation of the spleen in conjunction with splenic artery occlusion for treating secondary hypersplenism.

Detailed description: This open-label, single-arm, single-center clinical trial investigates the combined approach of microwave ablation of the spleen and splenic artery occlusion for managing secondary hypersplenism.

Eligibility criteria: Inclusion Criteria:

* 1. written informed consent signed prior to enrolment 2. age \> 18 years, both sexes 3.Patients with severe hypersplenism secondary to cirrhosis with clinical diagnosis, White blood cells \<3×109/L, and/or platelet \<50×109/L 4.Patients who have been repeatedly given drugs to raise white blood cells and platelets in clinical practice have poor effect 5.Mental problems such as clinical symptoms or anxiety in patients require interventional treatment for hypersplenism

Exclusion Criteria:

* Patients with any of the following are not eligible for enrollment in this study

  1. Coagulopathy or other blood disorders
  2. Recent use of anticoagulant drugs
  3. Severe hypertension and cardiac insufficiency
  4. Bone marrow aspiration results showed bone marrow suppression
  5. Combined with other spleen malignant diseases
  6. Severe skin infection at the puncture site
  7. Participated in other clinical studies within 2 months prior to the start of the study
  8. Patient or his/her authorized person is unwilling to sign a written informed consent form or unwilling to comply with the study protocol

Primary outcomes:
measure: Portal venous pressure
timeFrame: Up to 1 year
measure: Hepatic artery blood flow velocity
timeFrame: Up to 1 year
measure: Routine blood test
timeFrame: Up to 1 year
measure: Adverse Events
timeFrame: Up to 1 year
Secondary outcomes:
Other outcomes:
Locations:
city: Tianjin
country: China
facility: Tianjin Medical University Cancer Institute & Hospital
state: Tianjin
Study officials:
affiliation: Tianjin Cancer Hospital
name: WEI LU, PhD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT02150915: Acute Effects of Acupuncture in the Response of the Median Neurodynamic Test
Official title: Acute Effects of Acupuncture in the Response of the Median Neurodynamic Test: a Randomised, Double-blind, Non-inferiority Trial
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Other Lesions of Median Nerve
Keywords: Acupoints
Acupuncture therapy
Median nerve
Biomechanics
Lead sponsor: Universidade do Porto
Sponsor class: OTHER
Collaborators: name: Instituto Politécnico de Leiria
First posted: 2014-05-30
Enrollment: 32
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The purpose of this study is to test whether the application of acupuncture alters the mechanical (range of elbow extension motion) and physiological (eg, intensity and onset of discomfort, tingling feeling and/or feeling of tension or restriction of movement) responses of the neurodynamic test of nerve median in asymptomatic individuals

Detailed description: To understand the potential of acupuncture therapy in pain syndromes that involve changes of the mechanics and physiology of the peripheral nervous system

Eligibility criteria: Inclusion Criteria:

* age \> 18 years-old
* normal mobility in the joints of the upper quadrant

Exclusion Criteria:

* pathology that may impair nerve function (eg, diabetes)
* complaints over the past 3 months in the upper quadrant
* significant deformities in the upper quadrant

Primary outcomes:
measure: Elbow extension range of motion
timeFrame: immediately after the application of acupuncture
Secondary outcomes:
Other outcomes:
Locations:
city: Porto
country: Portugal
facility: Instituto de Ciências Biomédicas Abel Salazar - Universidade do Porto
Study officials:
affiliation: Universidade do Porto - Instituto de Ciências Biomédicas Abel Salazar
name: Henry J Greten, PhD
role: PRINCIPAL_INVESTIGATOR
References:
citation: Morais N, Greten HJ, Santos MJ, Machado JP. Immediate effects of acupuncture on the mechanosensitivity of the median nerve: an exploratory randomised trial. Acupunct Med. 2018 Jun;36(3):132-138. doi: 10.1136/acupmed-2016-011357. Epub 2018 May 2.
Clinical trial NCT05091515: Thermoregulatory Reactions of Medical Workers Who Use Personal Protective Equipment From Biological Hazards
Official title: Study of Thermoregulatory Reactions of the Body of Medical Workers Who Use Personal Protective Equipment From Biological Hazards
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Overheating
Keywords: Thermophysiology
Personal protective equipment from biological hazards
Medical workers
COVID-19
Working conditions
Lead sponsor: Federal State Budgetary Scientific Institution "Izmerov Research Institute of Occupational Health"
Sponsor class: OTHER
First posted: 2021-10-25
Enrollment: 25
Sex: ALL
Minimum age (years): 18
Maximum age (years): 55
Standard ages: ADULT
Accepts healthy volunteers: yes
Observational model: CASE_CONTROL
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Health workers

Brief summary: This research will provide data on thermal condition, functional status and working conditions of medical workers who use personal protective equipment from biological hazards. Acquired data will be used to define acceptable period of use for these protective costumes.

Detailed description: This research will recruit 14-20 volunteers. During 8 hours each subject will perform their work using protective costume. Heart rate, electrocardiogram, oxygenation, skin and air temperature under costume and hygrometric data will be registered. Also there will be questionnaires for volunteers for subjective assessment of thermal and moisture sensations and assessment of working conditions.

Eligibility criteria: Inclusion Criteria:

* healthy individuals (based on medical screening)

Exclusion Criteria:

* endocrinological diseases and disorders
* health deviations at the time of the study

Primary outcomes:
measure: Skin thermometry
timeFrame: 8 hours
measure: Hygrometry under costume
timeFrame: 8 hours
measure: Electrocardiography
timeFrame: 8 hours
measure: Blood pressure
timeFrame: 8 hours
measure: Heart rate
timeFrame: 8 hours
measure: Breathing rate
timeFrame: 8 hours
measure: Air thermometry and hygrometry
timeFrame: 8 hours
Secondary outcomes:
measure: Oxygenation
timeFrame: 8 hours
Other outcomes:
Locations:
city: Moscow
country: Russian Federation
facility: Federal State Budgetary Scientific Institution Izmerov Research Institute of Occupational Health
Study officials:
affiliation: Junior scientist
name: Alexey Konyukhov
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT06412185: Single Dose Escalation Study of CM383 in Healthy Volunteers
Official title: A Randomized, Double-blind, Placebo-controlled Phase I Clinical Study Evaluating the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics, and Immunogenicity of Single Dose Escalation of CM383 in Male Healthy Subjects
Study type: INTERVENTIONAL
Overall status: RECRUITING
Phase: PHASE1
Conditions: Alzheimer Disease
Lead sponsor: Keymed Biosciences Co.Ltd
Sponsor class: INDUSTRY
First posted: 2024-05-14
Enrollment: 56
Sex: MALE
Minimum age (years): 18
Maximum age (years): 80
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: SEQUENTIAL
Primary purpose: TREATMENT

Brief summary: This study is a single center, randomized, double-blind, placebo-controlled Phase I clinical study in a single dose escalation to evaluate its safety, tolerability, pharmacokinetics, pharmacodynamics, and immunogenicity of CM383 in male healthy subjects.

Detailed description: Alzheimer's disease (AD) is the most common type of dementia, which is a degenerative disease of the central nervous system with insidious onset and progressive development. Its clinical features mainly include memory impairment, cognitive impairment, psychobehavioral abnormalities, and social decline.

Eligibility criteria: Inclusion Criteria:

* Healthy males, voluntarily participate;
* 18 and 80 years old (including boundary values);
* able to communicate well with the researchers and follow up the protocol requirements.

Exclusion Criteria:

* The average daily smoking volume within three months before screening is greater than 5 cigarettes;
* Excessive alcohol consumption within three months before screening, or positive alcohol breath test;
* Urine drug abuse screening is positive;
* Having a family planning or sperm donation plan; Disagree to adopt efficient contraceptive measures.

Primary outcomes:
measure: Adverse events
timeFrame: Up to week 12
Secondary outcomes:
Other outcomes:
Locations:
city: Jinan
country: China
facility: Jinan Central Hospital
state: Shandong
Study officials:
affiliation: Jinan Central Hospital
name: Qing Wen
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT00117585: Orthostatic Hypotension in Rehabilitation Patients
Official title: Orthostatic Hypotension in Rehabilitation Patients
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Hypotension, Orthostatic
Keywords: Aging
Blood pressure
Hypotension
Orthostatic
Rehabilitation
Lead sponsor: VA Office of Research and Development
Sponsor class: FED
First posted: 2005-07-07
Enrollment: 341
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: TREATMENT

Brief summary: The purpose of this study is to determine the prevalence and clinical course of orthostatic hypotension (OH) on a rehabilitation and nursing home unit during their inpatient stay and to initiate a standardized, interdisciplinary treatment plan for patients with OH and determine the effect of treatment on the clinical course of OH during their inpatient stay.

Detailed description: This study is a prospective, quasi-experiment conducted in two consecutive phases. During the observation phase, eligible patients are identified and followed through their usual course of care in the nursing home/rehabilitation unit. During the intervention phase, patients enrolled who have OH will receive the intervention. Patients will be enrolled over two research phases and the investigators expect to evaluate 459 subjects. This research program will occur over a three-year period.

Methods:

During Phase I, baseline prevalence and natural history of OH will be determined by: enrolling consecutive appropriate subjects (able to stand, not end of life care) from a rehabilitation and nursing home unit and measuring OH 3 times weekly over their inpatient stay. In addition, chart review of diagnoses, medications, functional status, nutrition, and adverse events will be evaluated and correlated with clinical status. During Phase II, the investigators will implement a standardized, interdisciplinary (MD/RN/PT/Dietician) treatment plan for patients with OH. This will include chart review of diagnoses, medications, functional status, nutrition, adverse events, and correlation with clinical status. The goals of the interventions are to identify and treat the underlying causes of OH in rehabilitation patients. Based upon the comprehensive assessment, intervention participants will receive a standardized, interdisciplinary treatment regime.

Eligibility criteria: Inclusion Criteria:

* Admitted to Vancouver VA Nursing Home or Rehabilitation ward

Exclusion Criteria:

* Unable to stand upon admission
* Hospice admission
* Respite admission

Primary outcomes:
measure: Orthostatic Hypotension at Discharge
timeFrame: Last three blood pressures prior to discharge
Secondary outcomes:
Other outcomes:
Locations:
city: Portland
country: United States
facility: VA Portland Health Care System, Portland, OR
state: Oregon
Study officials:
References:
Clinical trial NCT02249585: Effects of Neuromuscular Blockade Level and Intra-abdominal Pressure on Surgical Conditions and Cardiopulmonary Responses During Laparoscopic Colon Surgery With the Trendelenburg Position
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Cardiac Index
Lead sponsor: Seoul National University Hospital
Sponsor class: OTHER
First posted: 2014-09-25
Enrollment: 131
Sex: ALL
Minimum age (years): 20
Maximum age (years): 90
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: PREVENTION

Brief summary: The purpose of this study is to find out the effect of low abdominal pressure vs. standard abdominal pressure on the cardiac and respiratory function of the patients undergoing laparoscopic colon surgery in Trendelenberg position. It was also designed to evaluate the effect of the degree of neuromuscular blockade on the surgical condition of the patients undergoing laparoscopic colon surgery in Trendelenberg position.


Eligibility criteria: Inclusion Criteria:

* Patients scheduled for laparoscopic colon surgery under Trendelenberg position

Exclusion Criteria:

* ASA classification IV
* Unable to make a written, informed consent
* Allergic to neuromuscular blocking agents, anesthetics, opioids
* Patients with neuromuscular disease
* Hepatic failure
* Renal failure
* History of malignant hyperthermia
* Morbid obesity with BMI\>35 kg/m2
* Patients enrolled in another clinical trials

Primary outcomes:
measure: Cardiac Index
timeFrame: 30 min after onset of laparoscopy
Secondary outcomes:
measure: Mean Arterial Blood Pressure (MBP)
timeFrame: 1, 30, 60, 90, and 120 minutes after onset of laparoscopy
measure: Stroke Volume Index (SVI)
timeFrame: 1, 30, 60, 90, 120 min after onset of laparoscopy
measure: PaO2
timeFrame: 1, 30, 60, 90, and 120 minutes after onset of laparoscopy
measure: Pulmonary Compliance
timeFrame: 1, 30, 60, 90, and 120 minutes after onset of laparoscopy
measure: Surgical Rating Scale
timeFrame: 1 min after laparoscopic procedure
Other outcomes:
Locations:
city: Seoul
country: Korea, Republic of
facility: Seoul National University Hospital
Study officials:
References:
Clinical trial NCT01148485: Community-acquired Methicillin-Resistant Staphylococcus Aureus Carriage Among Athletes
Official title: Community-acquired Methicillin-Resistant Staphylococcus Aureus Carriage Among Athletes: a Study in Limousin. : CA-MRSA
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Staphylococcus Aureus
Keywords: - Staphylococcus aureus Carriage among Athletes
Lead sponsor: University Hospital, Limoges
Sponsor class: OTHER
First posted: 2010-06-22
Enrollment: 300
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: CASE_ONLY
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: Athletes of Limousin practicing sport.

Brief summary: There are only very few data about the prevalence of CA-MRSA in France and no in athletes. In USA, the clone USA300 is widely disseminated and in Europe the clone ST80 predominates. The aim of the study was to study the carriage of S. aureus in athletes in a French county (Limousin) and to evaluate the proportion of CA-MRSA. The athletes will be met during their training, each one will fill-in a clinical information questionnaire. Nasal, throat, inguinal and skin lesions swab samples will be performed. The antibiotic susceptibility profile of the Staphyloccocus aureus strains isolated will be performed as well as the detection of the PVL gene. Strains will also be typed by different molecular methods (PGFE (Pulsed Gel Field Electrophoresis), SCCmec type (Staphylococcal Chromosome Cassette mec), and MLST (MultiLocus Sequence Typing)). The CIC (Clinical Investigation Center) of the Limoges University Hospital will be in charge of the inclusions of the athletes. The sample analysis will be centralized and performed at the Laboratory of Bacteriology of the Limoges University Hospital. A Clinical Research Officer of the Limoges University Hospital will be in charge of the survey of the study and will organize monthly meetings with all the participants of the study.


Eligibility criteria: Inclusion Criteria:

* adult patients (over 18),
* belonging to a sport club of Limousin, practicing rugby, wrestling, basket-ball, volley-ball, hand-ball, fence, martial art, football, weight lifting, and base-ball.
* Patient having signed in a free way and lit his consent to participate in this study

Exclusion Criteria:

* clinical information questionnaire not possible to fill,
* swab sample not possible to realize.

Primary outcomes:
measure: Presence of Methicillin-Resistant Staphylococcus aureus in the samples.
timeFrame: 1 year
Secondary outcomes:
measure: Comparison of the MRSA prevalence in athletes according to the sport
timeFrame: 1 year
Other outcomes:
Locations:
Study officials:
References:
citation: Couve-Deacon E, Postil D, Barraud O, Duchiron C, Chainier D, Labrunie A, Pestourie N, Preux PM, Francois B, Ploy MC. Staphylococcus Aureus Carriage in French Athletes at Risk of CA-MRSA Infection: a Prospective, Cross-sectional Study. Sports Med Open. 2017 Aug 16;3(1):28. doi: 10.1186/s40798-017-0094-z.
Clinical trial NCT04658485: The Effect of Transcranial Direct Current Stimulation of the Primary Motor and Somatosensory Cortex on Pain Thresholds.
Official title: The Modulatory Effect of Anodal Primary Motor Cortex and Cathodal Primary Somatosensory Cortex Transcranial Direct Current Stimulation on Pain Thresholds in the Neck Musculature.
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Healthy
Lead sponsor: Aalborg University
Sponsor class: OTHER
Collaborators: name: Danish National Research Foundation
First posted: 2020-12-08
Enrollment: 40
Sex: ALL
Minimum age (years): 18
Maximum age (years): 30
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: BASIC_SCIENCE

Brief summary: The purpose of this study is to investigate the modulatory effect of a novel tDCS configuration on the pain sensitivity in healthy subjects.

Detailed description: The purpose of this study is to investigate the modulatory effect of a single session 20 min anodal primary motor cortex (M1) and cathodal primary somatosensory cortex (S1) transcranial direct current stimulation (tDCS) on the pain sensitivity on the descending part of musculus trapezius in healthy young adults.

Eligibility criteria: Inclusion Criteria:

* Healthy
* Age between 18-30 years
* Living in Denmark

Exclusion Criteria:

* Pregnancy
* Drug addiction defined as the use of cannabis, opioids or other drugs
* Current use of opioids, antipsychotics, benzodiazepines
* Previous or current neurological, musculoskeletal, rheumatic, malignant, inflammatory or mental illnesses
* Current or prior chronic pain conditions
* Lack of ability to cooperate

Primary outcomes:
measure: Change in pressure pain threshold
timeFrame: Two assessments total: Once before the stimulation intervention (baseline assessment) and once again three minutes after the stimulation (post intervention assessment).
Secondary outcomes:
measure: Change in Heat and Cold Pain Detection Thresholds
timeFrame: Two assessments total: Once before the stimulation intervention (baseline) and once again five minutes after the stimulation (post intervention assessment).
Other outcomes:
Locations:
city: Aalborg
country: Denmark
facility: Center for Neuroplasticity and Pain
state: Nordjylland
Study officials:
affiliation: Aalborg University
name: Thomas Graven-Nielsen, Prof.
role: STUDY_DIRECTOR
References:
citation: Kold S, Kragh AJ, Graven-Nielsen CS, Elnegaard FS, Lund F, Vittrup IV, Cliff KL, Sivarooban R, Petrini L. Neuromodulation of somatosensory pain thresholds of the neck musculature using a novel transcranial direct current stimulation montage: a randomized double-blind, sham controlled study. Scand J Pain. 2022 Feb 7;22(3):622-630. doi: 10.1515/sjpain-2021-0187. Print 2022 Jul 26.
Clinical trial NCT01043185: A Study to Estimate Effect of 4 Different Doses of AZD3355 on Reflux Episodes, Which Patients With Gastroesophageal Reflux Disease (GERD) May Experience
Official title: A Double-blind, Placebo Controlled, Randomised, Phase IIA Pharmacodynamic 4-way Cross-over Study to Estimate the Dose Response Relationship of AZD3355 on the Number of Reflux Episodes Assessed by Impedance/pH in Patients With GERD and a Partial Response to PPI Treatment
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE2
Conditions: Gastroesophageal Reflux Disease
Keywords: GERD
lesogaberan
impedance
pH
pharmacokinetics
safety
tolerability
Lead sponsor: AstraZeneca
Sponsor class: INDUSTRY
First posted: 2010-01-06
Enrollment: 27
Sex: ALL
Minimum age (years): 18
Maximum age (years): 70
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: CROSSOVER
Primary purpose: TREATMENT

Brief summary: The purpose of the study is to estimate what effect 4 different doses of AZD3355 will have on the number of reflux episodes, in patients who have GERD and still experience symptoms despite proton pump inhibitor (PPI) treatment.


Eligibility criteria: Inclusion Criteria:

* Provide informed consent
* History of GERD with persistent symptoms despite treatment with PPI
* Otherwise normal physical health

Exclusion Criteria:

* History of GERD with symptoms that has not improved at all during treatment with PPI
* Prior surgery of the upper gastrointestinal tract
* History of significant heart disease, cardiovascular, respiratory, hepatic, renal, metabolic, psychiatric or gastrointestinal disorders besides GERD

Primary outcomes:
measure: Total Number of Reflux Episodes During 24 Hours
timeFrame: Measured during 24 hours at 4 different visits with a 7-28 days interval between
Secondary outcomes:
measure: Number of Acid Reflux Episodes
timeFrame: Measured during 24 hours at 4 different visits with a 7-28 days interval between
measure: Number of Weakly Acidic Reflux Episodes
timeFrame: Measured during 24 hours at 4 different visits with a 7-28 days interval between
measure: Number of Weakly Alkaline Reflux Episodes
timeFrame: Measured during 24 hours at 4 different visits with a 7-28 days interval between
Other outcomes:
Locations:
city: Oklahoma City
country: United States
facility: Research Site
state: Oklahoma
Study officials:
affiliation: Oklahoma Foundation of Digestive Research
name: Philip Miner
role: PRINCIPAL_INVESTIGATOR
affiliation: AstraZeneca
name: Debra G Silberg
role: STUDY_DIRECTOR
References:
citation: Miner PB Jr, Silberg DG, Ruth M, Miller F, Pandolfino J. Dose-dependent effects of lesogaberan on reflux measures in patients with refractory gastroesophageal reflux disease: a randomized, placebo-controlled study. BMC Gastroenterol. 2014 Nov 18;14:188. doi: 10.1186/1471-230X-14-188.