Clinical trial NCT04932889: Musculoskeletal Symptoms in Post Acute Covid-19 Patients
Official title: Musculoskeletal Symptoms and Related Factors in Post Acute Covid-19 Patients
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Covid19
Musculoskeletal Abnormalities
Lead sponsor: Eskisehir City Hospital
Sponsor class: OTHER
First posted: 2021-06-21
Enrollment: 280
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: CASE_CONTROL
Time perspective: RETROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: This retrospective cross-sectional study was carried out with the records of 280 post Covid-19 patients who admitted to the physical medicine and rehabilitation outpatient clinic between December 2020 and May 2021.

Brief summary: The patients whose musculoskeletal symptoms initiated or aggravated with Covid-19, were compared with the patients whose musculoskeletal symptoms did not change with Covid-19. The variables; the demographic and treatment datas, admission symptoms, post acute-Covid-19 symptoms, laboratory, chest computed tomography findings.

Detailed description: There is a lack of an overview of the factors associated with post acute-Covid-19 musculoskeletal symptoms. The aims are;1-to evaluate the most frequent admission symptoms and the frequency of musculoskeletal symptoms in post acute-Covid-19 patients,2-to determine the related factors with the post acute-Covid-19 musculoskeletal symptoms.

In this retrospective study; the patients whose musculoskeletal symptoms initiated or aggravated with Covid-19, were compared wthe patients whose musculoskeletal symptoms did not change with Covid-19. The variables; the demographic and treatment datas, admission symptoms, post acute-Covid-19 symptoms, laboratory (complete blood count, C-reactive protein, ferritin, D-dimer), chest computed tomography findings.

Eligibility criteria: Inclusion Criteria:

* Being 18 years or older
* Having Covid-19 treatment (home quarantine / hospital / intensive care unit) according to a positive polymerase chain reaction (PCR) test in a nasopharyngeal + oropharyngeal swab or chest CT.

Exclusion Criteria:

* Patients who did not have musculoskeletal symptom records (admission symptoms and musculoskeletal symptoms such as; fatigue, spine / joint /muscle pain/ numbness) in patients files
* Acute Covid-19 patients whose symptoms started less than 1 month

Primary outcomes:
measure: Rate of back pain
timeFrame: Baseline
measure: Chest computed tomography
timeFrame: Baseline
measure: Rate of low-back pain
timeFrame: Baseline
measure: Rate of fatigue
timeFrame: Baseline
measure: Rate of neck pain
timeFrame: Baseline
measure: Rate of dyspnea
timeFrame: baseline
measure: Rate of joint pain
timeFrame: Baseline
measure: Rate of chest pain
timeFrame: Baseline
measure: Rate of myalgia
timeFrame: Baseline
Secondary outcomes:
measure: age
timeFrame: Baseline
measure: Weight
timeFrame: Baseline
measure: gender
timeFrame: Baseline
measure: Duration after the onset of covid-19
timeFrame: Baseline
measure: Lymhocyte levels
timeFrame: Baseline
measure: D-dimer levels
timeFrame: Baseline
measure: C-reactive protein
timeFrame: Baseline
measure: Hemoglobin
timeFrame: Baseline
measure: Platelet
timeFrame: Baseline
measure: Ferritin
timeFrame: Baseline
Other outcomes:
Locations:
city: Eskişehir
country: Turkey
facility: Eskişehir City Hospital
Study officials:
affiliation: Eskişehir City Hospital
name: Fulya Bakılan
role: PRINCIPAL_INVESTIGATOR
References: