Clinical trial NCT06712511: The Effect of Coffee on Energy Expenditure and Caffeine Metabolism
Official title: The Effect of Coffee on Energy Expenditure and Caffeine Metabolism
Study type: INTERVENTIONAL
Overall status: RECRUITING
Phase: NA
Conditions: Healthy
Keywords: Coffee
Caffeine
Energy expenditure
Caffeine metabolism
Lead sponsor: Shenzhen Institutes of Advanced Technology ,Chinese Academy of Sciences
Sponsor class: OTHER
First posted: 2024-12-02
Enrollment: 60
Sex: ALL
Minimum age (years): 18
Maximum age (years): 40
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: BASIC_SCIENCE

Brief summary: Obesity is a risk factor for chronic diseases, and improving energy expenditure is a way to prevent and treat obesity. The purpose of this project is to explore the relationship between the effect of coffee on energy expenditure and caffeine metabolism, which has important significance in the rational application of caffeine.

Detailed description: The investigators will study the relationship between the effect of coffee on energy expenditure and caffeine metabolism. The investigators will recruit healthy participants. Participants will be forbidden to consume stimulant drinks such as coffee for 24 hours before the experiment. When the participants arrive at the lab on the day of the experiment, they will sign an informed consent form, a health history questionnaire and a daily coffee consumption questionnaire. The changes of drinking water/coffee on total energy expenditure (TEE), body temperature, heart rate, blood pressure, electrocardiogram, memory，cognition, sleep time and so on will be observed. The concentration of caffeine and its metabolites in the blood and urine will be measured by liquid chromatography-mass spectrometry (LC-MS) and gas chromatography-mass spectrometry (GC-MS).

Eligibility criteria: Inclusion Criteria：

* Healthy adults.
* Must be able to drink coffee.

Exclusion Criteria:

* Diabetes.
* Hypoglycemia.
* Gout.
* Osteoporosis.
* Gastric ulcer.
* Pancreatitis.
* Intestinal obstruction.
* Blood phobia.
* Pathological hypo or hyper tension.
* Impaired glucose tolerance.
* Claustrophobia.
* HIV,etc.

Primary outcomes:
measure: Total energy expenditure
timeFrame: 2 days
measure: The concentration of caffeine and its metabolites in urine
timeFrame: 2 days
measure: The concentration of caffeine and its metabolites in serum
timeFrame: 1 day
Secondary outcomes:
measure: Body temperature
timeFrame: 2 days
measure: Electrocardiogram (ECG)
timeFrame: 2 days
measure: Blood pressure
timeFrame: 2 days
measure: Height
timeFrame: The morning of the first day of the experiment, 5 mins
measure: Body weight
timeFrame: The morning of the first day of the experiment, 5 mins
measure: Fat mass
timeFrame: The morning of the first day of the experiment, 10 mins
measure: Fat free mass
timeFrame: on the morning of the experiment, 5 mins
measure: Heart rate
timeFrame: 2 days
measure: Hunger rating
timeFrame: 2 days
measure: Memory and cognitive tests
timeFrame: The morning of the experiment, 60 mins
measure: Physical activity
timeFrame: 7 days
measure: Sleep duration
timeFrame: 2 days
measure: Waist circumferences
timeFrame: The morning of the first day of the experiment,10 mins.
Other outcomes:
Locations:
city: Shenzhen
country: China
facility: Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences
state: Guangdong
Study officials:
affiliation: Shenzhen Institutes of Advanced Technology ,Chinese Academy of Sciences
name: John R Speakman, PhD
role: STUDY_CHAIR
References: