louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT02396836: Randomised Controlled Trial (RCT) of 6 Versus 3 Steps for Hand Hygiene
Official title: Randomised Controlled Trial of the Effectiveness of Two Hand Hygiene Techniques Using Alcohol Based Hand Rub on Hand Surface Coverage and Reducing Bacterial Hand Contamination
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Hand Hygiene
Keywords: Hand hygiene
Hand decontamination
Microbial load
Hand coverage
Glove juice technique
Ayliffe technique
6 step technique
Lead sponsor: Glasgow Caledonian University
Sponsor class: OTHER
Collaborators: name: University of Strathclyde
name: University of East Anglia
name: NHS Greater Glasgow and Clyde
name: Tan Tock Seng Hospital
First posted: 2015-03-24
Enrollment: 120
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: HEALTH_SERVICES_RESEARCH

Brief summary: The aim is to compare the effectiveness of the 6 step hand rub technique versus 3 step hand rub technique in hand coverage and in reducing bacterial contamination on the hands of healthcare workers in practice.

Research questions

1. What is the effectiveness of the 6 step technique in hand coverage compared to the 3 step technique?

   1. What are the most frequently missed sites in hand surface coverage using 6 steps compared to 3 steps?
   2. What is the reduction in bacterial contamination of the hand with the 6 step compared to the 3 step technique?
2. Does site missed or coverage relate to bacterial load?
3. What is the time taken for 6 step technique versus 3 step technique?

Detailed description: The 6 step for decontamination of healthcare workers hand is recommended by the World Health Organization but the 3 step technique is easy to perform and has been shown by some studies to be effective. Compliance with the 6 step technique is not optimum. If the 3 step was more as or more effective than the 6 step compliance with it could be compared with that for the 6 step. No randomised controlled trial comparing the effectiveness of these two techniques using alcohol based hand rub has been conducted.

Eligibility criteria: Inclusion Criteria:

* Medical and nursing staff performing a clinical procedure

Exclusion Criteria:

* A procedure requiring use of gloves
* A self declared active skin condition

Primary outcomes:
measure: Microbial load on dominant hand
timeFrame: up to 5 min
Secondary outcomes:
measure: Hand coverage
timeFrame: up to 5 min
Other outcomes:
Locations:
city: Glasgow
country: United Kingdom
facility: Western Infirmary
Study officials:
affiliation: Glasgow Caledonian University
name: Jacqui Reilly, PhD
role: PRINCIPAL_INVESTIGATOR
References:
citation: Reilly JS, Price L, Lang S, Robertson C, Cheater F, Skinner K, Chow A. A Pragmatic Randomized Controlled Trial of 6-Step vs 3-Step Hand Hygiene Technique in Acute Hospital Care in the United Kingdom. Infect Control Hosp Epidemiol. 2016 Jun;37(6):661-6. doi: 10.1017/ice.2016.51. Epub 2016 Apr 7.
Clinical trial NCT03240536: Choosing Tests Wisely in Rheumatology
Official title: Choosing Tests Wisely in Rheumatology
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: SLE
Keywords: Rheumatology Referral
Choosing Wisely
Lead sponsor: London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Sponsor class: OTHER
First posted: 2017-08-07
Enrollment: 638
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Intervention model description: Randomized Study
Primary purpose: HEALTH_SERVICES_RESEARCH

Brief summary: This is a randomized study intended to produce a reduction in ordering of inappropriate tests by general practitioners as determined by recommendations from the CRA's Choosing Wisely guidelines. This reduction of inappropriate testing is expected in referrals to the rheumatologists randomized to the intervention group. This study will further explore which recommendations from the Canadian Rheumatology Association (CRA)/Canada Choosing Wisely campaign have the most impact on regional referring physicians to the Rheumatology clinic at St. Joseph's Hospital, London.

Detailed description: This a randomized study in that 6 rheumatologists (30 referrals each) will be randomized to one of two groups: intervention or control. Referring physicians to the intervention group will be faxed a brief Choosing Wisely form (intervention) based upon the recommendations of the Canadian Rheumatology Association's (CRA) Canada Choosing Wisely campaign, while referring physicians from the control group will not receive the form (non intervention). Analysis will be based upon the results of a three question survey faxed to all referring physicians at year one and at year two and on future referrals from the referring physicians to determine if there is a reduction in the group of ordering physicians that received the intervention (Choosing Wisely form).

Eligibility criteria: Inclusion Criteria:

* Ordering physicians who recently made a referral to the Rheumatology clinic at St. Joseph's Health Care.

Exclusion Criteria:

* N/A, all recent referrals will be included.

Primary outcomes:
measure: Assessing the change in the number of the total number of ANA tests, back CT's and shoulder ultrasounds in rheumatology referrals
timeFrame: Change from baseline number of tests at year one, year two
Secondary outcomes:
Other outcomes:
Locations:
city: London
country: Canada
facility: St. Joseph's Health Care London
state: Ontario
Study officials:
References:
Clinical trial NCT06408636: Prognostic Role of LA Strain in Acute Myocardial Infarction
Official title: Cardiac MRI Left Atrial Strain Associated With Ischemic Stroke in Patients With Acute Myocardial Infarction
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Atrial Fibrillation
Myocardial Infarction, Acute
Stroke Ischemic
Mortality
Keywords: cardiac magnetic resonance
myocardial infarction
atrial fibrillation
ischemic stroke
Lead sponsor: The Affiliated Hospital of Xuzhou Medical University
Sponsor class: OTHER
First posted: 2024-05-10
Enrollment: 780
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: RETROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: This is a single-center retrospective observational study in which we consecutively selected patients diagnosed with acute myocardial infarction from September 2019 to March 2024 at the Affiliated Hospital of Xuzhou Medical University. Dedicated cardiovascular imaging software CVI42 (cvi42® version 5.13.5, Circle Cardiovascular Imaging, Canada) was used for image analysis. LA strain was obtained by cardiac MRI feature tracking. Patient prognosis was obtained through chart notes and telephone follow-up. Major events included atrial fibrillation, ischemic stroke, and all-cause mortality.

Brief summary: This is a single-center retrospective observational study in which we consecutively selected patients diagnosed with acute myocardial infarction from September 2019 to March 2024 at the Affiliated Hospital of Xuzhou Medical University. Inclusion criteria: 1. CMR was completed during all hospitalizations; 2. complete clinical data; 3. received continuous cardiac monitoring during hospitalization. Exclusion criteria: 1. unclear or non-compliant CMR images; 2. previous history of myocardial infarction; 3. malignant tumors diseases. Dedicated cardiovascular imaging software CVI42 (cvi42® version 5.13.5, Circle Cardiovascular Imaging, Canada) was used for image analysis. LA strain was obtained by cardiac MRI feature tracking. Patient prognosis was obtained through chart notes and telephone follow-up. Major events included atrial fibrillation, ischemic stroke, and all-cause mortality.


Eligibility criteria: Inclusion Criteria:

* 1.CMR was completed during all hospitalizations; 2. complete clinical data; 3. received continuous cardiac monitoring during hospitalization.

Exclusion Criteria:

* 1.unclear or non-compliant CMR images; 2. previous history of myocardial infarction; 3. malignant tumors diseases.

Primary outcomes:
measure: Primary endpoint events included all-cause death, ischemic stroke, and atrial fibrillation
timeFrame: All patients were followed until March 31, 2024
Secondary outcomes:
Other outcomes:
Locations:
city: Xuzhou
country: China
facility: The Affiliated Hospital of Xuzhou Medical University
state: Jiangsu
Study officials:
References:
Clinical trial NCT00530036: Burden of Urinary Incontinence in Home Care Patients in the State of Geneva
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Urinary Incontinence
Keywords: Mortality
Patient readmission
Institutionalization
Lead sponsor: University Hospital, Geneva
Sponsor class: OTHER
First posted: 2007-09-17
Enrollment: 699
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: DEFINED_POPULATION
Time perspective: RETROSPECTIVE

Brief summary: Urinary incontinence (UI) is a frequent problem in community-dwelling older adults and has a huge burden on health complications and healthcare costs. Although effective treatments exist, UI is frequently neglected resulting in unmet needs for continence treatment and potential negative health outcomes. The impact of UI in older patients receiving home care services has not been extensively explored. In a recent study we observed that UI was identified in 46% of 699 patients followed by the "Fondation des Services d'Aide et de Soins à Domicile" in Geneva but the impact of UI on outcome such as institutionalization, hospitalization or death is unknown.


Eligibility criteria: Inclusion Criteria:

* Between July 2004 and December 2004
* 699 adults patients followed by the "Fondation des Services d'Aide et de Soins à Domicile" in Geneva (two region in the state of Geneva: Meyrin and St-Jean)

Primary outcomes:
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
affiliation: University Hospital of Geneva (HUG)
name: Michel Jung, MD
role: PRINCIPAL_INVESTIGATOR
References:
citation: Jung M, Faltin DL, Rutschmann O. [Impact of urinary incontinence in community-dwelling women]. Rev Med Suisse. 2006 Oct 18;2(83):2332-5. French.
Clinical trial NCT04123236: The Relationship of Orthodontic Malocclusions With Temporomandibular Joint Disorders
Official title: Investigation of the Relationship of Orthodontic Malocclusions With Temporomandibular Joint Disorders by Helkimo's Indices and Oral Health Impact Profile-14
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Temporomandibular Joint Disorders
Lead sponsor: University of Gaziantep
Sponsor class: OTHER
First posted: 2019-10-10
Enrollment: 250
Sex: ALL
Minimum age (years): 12
Maximum age (years): 27
Standard ages: CHILD
ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: CROSS_SECTIONAL
Sampling method: PROBABILITY_SAMPLE
Study population: Patients wish to receive orthodontic treatment in our clinic.

Brief summary: The patients who applied to the hospital for orthodontic treatment were asked various questions to evaluate their oral health related quality of life, malocclusions and self reported temporomandibular joint problems.

Detailed description: The patients who applied to the hospital for orthodontic treatment were asked various questions to evaluate their oral health related quality of life, malocclusions and self reported temporomandibular joint problems. For this purposes Oral Health Impact Profile-14, and Helkimo's indexes were used.The relationship between these results were investigated.

Eligibility criteria: Inclusion Criteria:

* wish to receive orthodontic treatment in our clinic.

Exclusion Criteria:

* The absence of willingness for the temporomandibular joint and clinical examination or answering the survey questions.

Primary outcomes:
measure: Oral Health Impact Profile
timeFrame: through study completion, an average of 2 months. The scale ranged from 0-5. All data will be summed at the end of the study. Higher values means worse quality of life standard
measure: Helkimo's anamnestic dysfunction index
timeFrame: through study completion, an average of 2 months. The scale ranged from 0-3. Higher scale means worse quality of life standards
measure: Helkimo's clinical dysfunction index
timeFrame: through study completion, an average of 2 months. The scale ranged from 0-3. Higher scale means worse quality of life standards
measure: Visual analog scale
timeFrame: through study completion, an average of 2 months.
Secondary outcomes:
Other outcomes:
Locations:
city: Gaziantep
country: Turkey
facility: Gaziantep University
state: Şehitkamil
Study officials:
affiliation: University of Gaziantep
name: Merve Goymen, PhD
role: STUDY_CHAIR
affiliation: Yuzuncu Yıl University
name: Yeşim Kaya
role: STUDY_CHAIR
References:
Clinical trial NCT02502136: Efficacy and Safety of Carbon Dioxide Insufflation During Endoscopy
Official title: The Assessment of Differences in Clinical Safety and Efficacy of Carbon Dioxide Insufflation During Sedated and Conventional Endoscopy
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Carbon Dioxide Insufflation During Colonoscopy
Keywords: CO2 insufflation
Lead sponsor: Chang Gung Memorial Hospital
Sponsor class: OTHER
First posted: 2015-07-20
Enrollment: 640
Sex: ALL
Minimum age (years): 20
Maximum age (years): 80
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: SUPPORTIVE_CARE

Brief summary: The purpose of this study is to assess the differences of safety and efficacy of carbon dioxide insufflation instead of air during sedated or unsedated endoscopy.

Detailed description: Total 640 participants who are indicated to accept endoscopic examinations or procedures will be enrolled in this study. The participants will be divided into 2 groups according to the examination field, esophagogastroduodenoscopy group (320 participants) and colonoscope group (320 participants). The participants in each group will be divided into sedated endoscope subgroup and sedated and unsedated endoscope subgroup (each subgroup is inclusive of 160 participants). Carbon dioxide (CO2) or room air will be used randomly to insufflate the bowel lumen during the procedure in each subgroup.

Eligibility criteria: Inclusion Criteria:

* outpatients referred for panendoscopy or colonoscopy examination

Exclusion Criteria:

* pregnancy, breast feeding, severe chronic obstructive lung disease or severe heart failure, renal function impairment, inability to understand participant information, a history of abdominal surgery, or refusal to participate in this study

Primary outcomes:
measure: the participants' discomfort scale after endoscopy
timeFrame: within 24hours
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
affiliation: Chang Gung Memorial Hospital
name: Shuo-Wei Chen, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT03399136: Fitness and Longevity in Exercise
Official title: Fitness and Longevity in Exercise
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: HIV-1-infection
Aging
Keywords: Exercise training
Intervention
Aerobic capacity
Lead sponsor: University of Maryland, Baltimore
Sponsor class: OTHER
First posted: 2018-01-16
Enrollment: 31
Sex: ALL
Minimum age (years): 50
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: OTHER

Brief summary: The study objective was to determine the safety and efficacy of aerobic exercise in older HIV-infected men in a randomized trial comparing different levels of exercise intensity.

Detailed description: The study was a randomized trial of moderate-intensity versus high-intensity aerobic exercise (AEX) training in older HIV-infected adults. Funding was provided by K23 AG024896 (PI, Oursler) and the UMB Claude D. Pepper Older Americans Independence Center P60 AG12583 (PI, Goldberg).

The central hypothesis was that high-intensity AEX training is well-tolerated and significantly increases aerobic capacity in older HIV-infected adults.

The study met its objectives:

1. Scientific AIMS met:

   1. High-intensity AEX training significantly increases aerobic capacity
   2. Both moderate-intensity and high-intensity AEX training improve ambulatory function and endurance.
   3. Activity of skeletal muscle oxidative enzymes is reduced, and associated with aerobic capacity.
2. Feasibility Objectives met:

   1. AEX training is safe and well-tolerated in older HIV-infected adults.
   2. Skeletal muscle punch biopsy is safe and well-tolerated in older HIV-infected adults.
   3. Preliminary data was collected on plasma biomarkers of inflammation.

Eligibility criteria: Inclusion Criteria:

* HIV+
* stable combination antiretroviral therapy (cART)

Exclusion Criteria:

* AIDS defining conditions in the prior six months
* Conditions that increase the risk of exercise training per the American College of Sports Medicine (ACSM)

Primary outcomes:
measure: Change from baseline Cardiorespiratory Fitness at 16 weeks
timeFrame: 16-weeks
Secondary outcomes:
measure: Change from baseline Six-minute walk distance at 16 weeks
timeFrame: 16-weeks
measure: Change from baseline body composition at 16 weeks
timeFrame: 16-weeks
measure: Change from baseline exercise endurance at 16 weeks
timeFrame: 16-weeks
Other outcomes:
measure: skeletal muscle oxidative function
timeFrame: baseline
Locations:
Study officials:
affiliation: University of Maryland, Baltimore
name: Krisann Oursler, MD
role: PRINCIPAL_INVESTIGATOR
References:
citation: Ortmeyer HK, Ryan AS, Hafer-Macko C, Oursler KK. Skeletal muscle cellular metabolism in older HIV-infected men. Physiol Rep. 2016 May;4(9):e12794. doi: 10.14814/phy2.12794.
Clinical trial NCT03218436: Physical Cold Atmospheric Plasma for the Treatment of Cervical Intraepithelial Neoplasia
Official title: Physical Cold Atmospheric Plasma for the Treatment of Cervical Intraepithelial Neoplasia
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Cervical Intraepithelial Neoplasia
Lead sponsor: University Hospital Tuebingen
Sponsor class: OTHER
First posted: 2017-07-14
Enrollment: 63
Sex: FEMALE
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NON_RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: Cervical intraepithelial neoplasia will be treated with physical low temperature plasma in the plasma cohort compared to watchful waiting in the control cohort.

Primary endpoint after 3-6 months: Pathological remission.

Secondary endpoint: HPV remission.

Detailed description: The study was completed with Less recruitment as it was planned due to overwhelming study success. The study was published in August 2023. A link has been added to the Reference section.

Eligibility criteria: Inclusion Criteria for CAP:

* Histologically confirmed CIN I / II
* Reliable assessment of the radius of the portio and marginal borders of the lesions
* Written consent for treatment with low temperature plasma after reconnaissance

Inclusion Criteria for Control-Group:

* Histologically confirmed CIN I / II
* Reliable assessment of the radius of the portio and marginal borders of the lesions
* Patients who want a waiting procedure and a control examination after 3-6 months

Exclusion Criteria:

* Histologically confirmed CIN III
* Not fully visible transformation zone
* An indication of invasive disease
* Expected lack of compliance of the patient or incapacity of the patient to understand the meaning and purpose of the clinical trial
* Severe cardio-vascular disease
* Lack of patient consent

Primary outcomes:
measure: Pathological remission of cervical intraepithelial neoplasia
timeFrame: 3-6 months
Secondary outcomes:
measure: Human papilloma virus remission rate
timeFrame: 3-6 months
measure: Comfort / Dyscomfort during intervention
timeFrame: Immediately, 2 week, 3-6 months
Other outcomes:
Locations:
city: Tübingen
country: Germany
facility: Department for Women's Health
Study officials:
affiliation: Department for Women's Health
name: Melanie Henes, Dr.
role: PRINCIPAL_INVESTIGATOR
affiliation: Department for Women's Health
name: Martin Weiss, Dr.
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT06647836: The Therapeutic Effect of Immunotherapy in Patients With Advanced Lung Squamous Carcinoma
Official title: Exploration of the Treatment Trajectory and Drug Resistance Mechanism of Immunotherapy Combined With Chemotherapy in Patients With Advanced Lung Squamous Carcinoma
Study type: OBSERVATIONAL
Overall status: ENROLLING_BY_INVITATION
Conditions: Squamous Cell Lung Cancer
Lead sponsor: Wuhan Union Hospital, China
Sponsor class: OTHER
First posted: 2024-10-18
Enrollment: 1000
Sex: ALL
Minimum age (years): 18
Maximum age (years): 80
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: OTHER
Sampling method: NON_PROBABILITY_SAMPLE
Study population: From January 2021 to December 2025, about 1000 patients with sq-NSCLC receiving immunotherapy combined with or without chemotherapy as first-line treatment will be enrolled in this cohort study.

Brief summary: The aim of this observational study is to investigate the treatment trajectory of immunotherapy in patients with squamous non-small cell lung cancer (sq-NSCLC). The primary objective is to identify potential indicators that can predict the efficacy of immunotherapy and explore strategies to prolong its effectiveness in sq-NSCLC patients. Biological specimens and medical imaging data will be collected from patients already receiving immunotherapy as a first-line treatment, and follow-up will be conducted to analyze prognosis based on different patterns.

Detailed description: The medical imaging data will be collected retrospectively and prospectively and the blood samples and tumor tissues will be collected prospectively.

Eligibility criteria: Inclusion Criteria:

* Diagnosed with sq-NSCLC;
* Receiving immunotherapy combined with or without chemotherapy as first-line treatment;
* ≥ 18 years and ≤ 80 years old;
* No previous treatment in the lungs or any other organ.

Exclusion Criteria:

* History of cancer treatment;
* History of other malignant tumors;
* Irregular treatment or poor compliance;
* Incomplete clinical information or lost to follow-up.

Primary outcomes:
measure: progression-free survival
timeFrame: A two-year period after starting treatment (Regular follow-up every three months after receiving immunotherapy combined with or without chemotherapy as first-line treatment)
Secondary outcomes:
measure: Overall survival
timeFrame: A three-year period after starting treatment (Regular follow-up every six months after receiving immunotherapy combined with or without chemotherapy as first-line treatment)
Other outcomes:
Locations:
city: Wuhan
country: China
facility: Union Hospital, Tongji Medical college, Huazhong University of Science and Technology
state: Hubei
Study officials:
affiliation: Wuhan Union Hospital, China
name: Xueyun Tan, MD
role: STUDY_DIRECTOR
affiliation: Wuhan Union Hospital, China
name: Yang Jin, PHD
role: PRINCIPAL_INVESTIGATOR
References: