louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT03145246: Long-Term Outcome Following Regenerative Periodontal Treatment of Intrabony Defects
Official title: Long-Term Outcome Following Regenerative Periodontal Treatment of Intrabony Defects: A Retrospective Study at Mahidol University
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Regenerative Periodontal Treatment
Keywords: intrabony defect
periodontal regeneration
Lead sponsor: Mahidol University
Sponsor class: OTHER
First posted: 2017-05-09
Enrollment: 89
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: OTHER
Time perspective: RETROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: The patients who received regenerative periodontal therapy of the intrabony defects by post-graduate students at the Periodontics and Oral Medicine Clinic, Faculty of Dentistry, Mahidol University, Thailand and were placed in the Recall Patient Bank from 2000 to 2014.

Brief summary: Many years ago, periodontal regenerative treatment has been done in Periodontics and Oral Medicine Clinic, Faculty of Dentistry, Mahidol University, Bangkok, Thailand. However, there is still lacking of study about long-term result of periodontal regenerative treatment of intrabony defects.

Detailed description: Beside, in the present, some materials for periodontal regenerative treatment are still expensive. Periodontists and patients have to plan together based on not only rationale of treatment but also cost and effectiveness. Thus the long-term result of treatment could be useful for the decision making.

Eligibility criteria: Inclusion Criteria:

* Patients who received regenerative therapy of the intrabony defects
* Patients who had the record of re-evaluation at 1 year post-surgery

Exclusion Criteria:

* Patients who received regenerative therapy involving the furcation area
* Patients who received non-periodontal regenerative therapy
* Patients who received endodontic regeneration
* Patients who had an incomplete periodontal data recording

Primary outcomes:
measure: Percentage of regenerative-treated tooth loss after periodontal regeneration
timeFrame: 1 year
measure: Percentage of regenerative-treated sites with clinical attachment loss ≥ 2 mm
timeFrame: 1 year
Secondary outcomes:
measure: Variables (patient and tooth characteristics) that associated with tooth loss or clinical attachment loss
timeFrame: 1 year
Other outcomes:
Locations:
Study officials:
affiliation: Mahidol University
name: Kanyawat Rattanasuwan
role: STUDY_DIRECTOR
References:
Clinical trial NCT06695546: Evaluation of the Venous Excess Ultrasound Score (VExUS) After Circulating Volume Modification in Children.
Official title: Evaluation of the Venous Excess Ultrasound Score (VExUS) After Circulating Volume Modification in Children. VExUS-Mod
Study type: OBSERVATIONAL
Overall status: RECRUITING
Conditions: Blood Volume Expansion
Keywords: extra renal purification
bleeding
vascular filling
Lead sponsor: University Hospital, Toulouse
Sponsor class: OTHER
First posted: 2024-11-19
Enrollment: 56
Sex: ALL
Minimum age (years): 1
Maximum age (years): 18
Standard ages: CHILD
ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: All children aged between 1 and 18 years, receiving extrarenal purification with UF \> 10 ml/kg, bleeding \> 10 ml/kg or vascular filling \> 10 ml/kg treated at Toulouse University Hospital.

Brief summary: Venous overload has an impact on peripheral organ perfusion and on the short- and long-term prognosis of intensive care patients. The VExUS ultrasound score is a new tool whose parameters can be used to estimate this impact. This score was initially evaluated and validated on an adult population. ) In children, there is only one study looking at the use and applicability of this VExUS score, highlighting its feasibility in a paediatric population, as well as a possible correlation between elevated central venous pressure and altered renal Doppler (one of the score's components).


Eligibility criteria: Inclusion Criteria:

Children aged between 1 and 18 years, receiving extrarenal purification with UF \> 10 ml/kg, bleeding \> 10 ml/kg or vascular filling \> 10 ml/kg

Exclusion Criteria:

* Refusal of the patient or opposition of one or both holders of parental authority.
* Minors with parental authority.
* Ultrafiltration time \> 6h.
* Curarized patient, known abnormality of the hepatorenal venous network.
* Patient agitated or poor tolerance of the examination.
* Parents under court protection, guardianship or curatorship.

Primary outcomes:
measure: Change in VExUS score
timeFrame: 10 minutes before en after the procedure of extrarenal purification, bloodletting or vascular filling
Secondary outcomes:
Other outcomes:
Locations:
city: Toulouse
country: France
facility: CHU Toulouse
Study officials:
affiliation: CHU Toulouse
name: Montserrat SIERRA COLOMINA, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT01810146: Characterization of the Digestive Functions and the Enteric Nervous System in Obesity. Investigations of Relationships With Metabolism Disorders (EnteroNeurObesity)
Official title: Characterization of the Digestive Functions and the Enteric Nervous System in Obesity. Investigations of Relationships With Metabolism Disorders(EnteroNeurObesity)
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Obesity
Keywords: Patients eligible for bariatric surgery (BMI>40kg/m2)
Lead sponsor: Nantes University Hospital
Sponsor class: OTHER
First posted: 2013-03-13
Enrollment: 40
Sex: ALL
Minimum age (years): 18
Maximum age (years): 65
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: BASIC_SCIENCE

Brief summary: 60 patients scheduled for bariatric surgery will be included into 3 categories (20 patients with non complicated obesity, 20 patients with metabolic syndrome and 20 patients with a type 2 diabetes or hypertension). 20 volunteers will be enrolled as normal referents. The patients and the volunteers will have a classical pre-operative check-up (fibroscopy, oesophageal pHmetry and manometry) and extra investigations as isotopic gastric empty exam, lactulose oro-caecal transit exam, intestinal permeability test calculated by lactulose-manitol ratio urinary excretion. Intestinal and colonic biopsies will be also provided for studying permeability. For only patients, samples from the gastric resection will be provided for analysing the enteric nervous system and motricity.


Eligibility criteria: Patients:

Patients must be aged between 18 and 65 years old with a BMI\>40kg/m2 for non complicated patients or with a metabolic syndrome and with a BMI\>35kg/m2 for patients with type 2 diabetes or hypertension. They must be eligible for bariatric surgery.

Patients with a type 1 diabetes, neurologic or neuro-degenerative disease will be excluded.

Volunteers:

Volunteers must be aged between 18 and 65 years old with a BMI between 20 and 25kg/m2 Men and women are eligible.

Primary outcomes:
measure: T1/2 solids (on the kinetic of isotopic gastric empty exam)
timeFrame: 6 months
Secondary outcomes:
Other outcomes:
Locations:
city: Nantes
country: France
facility: University Hospital
Study officials:
References:
Clinical trial NCT01047046: Combined Anticholinergic Medication and Sacral Neuromodulation to Treat Refractory Overactive Bladder
Official title: Use of Combined Anticholinergic Medication and Sacral Neuromodulation in the Treatment of Refractory Overactive Bladder
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Overactive Bladder
Keywords: SNM device
Chart review of patients with surgical placed SNM device
Lead sponsor: University of California, Irvine
Sponsor class: OTHER
First posted: 2010-01-12
Enrollment: 88
Sex: FEMALE
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: RETROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Patients who have undergone a placement of a SNM device to treat refractory OAB. A retrospective chart review will be performed on all patients who underwent a one or two-stage placement of an SNM device, which includes an implantable pulse generator (IPG), for refractory urge incontinence and urgency frequency symptoms. The patients will be those of Dr. Karen Noblett, having their device placed after 2001.

Brief summary: This study is a retrospective chart review including all patients who received surgical placement of a SNM device with Dr. Noblett from 2001 to the present.

Detailed description: The following data will be collected from patient charts: age at time of surgery, gravidity/parity, body mass index, pre-existing medical conditions/surgical history, current medications, menopausal status, form and severity of OAB symptoms, other previously or currently used interventions, method of SNM device placement, observed motor/sensory response, percent improvement of symptoms, follow-up OAB symptoms, frequency of InterStim settings adjustments, adverse events, significant changes in health, and incidence/reason for drop out.

Eligibility criteria: Inclusion Criteria:

* Female patients with symptoms of OAB, namely urge incontinence and urgency-frequency.
* Ages 18 and older.

Exclusion Criteria:

* Any patient who received surgical placement of an SNM device to treat non-obstructive urinary retention, or the symptoms of an underlying neurologic pathology, such as Parkinson's or Multiple Sclerosis.

Primary outcomes:
measure: Prevalence of combined therapy - determine the nmbr of pts on anticholinergic medication to treat symptoms of OAB after placement of SNM device, examine outcomes and defining characteristics of these pts compared to those not receiving anticholinergics.
timeFrame: Retrospective chart review
Secondary outcomes:
measure: Predictors of SNM therapy success - collect data factors; previously trialed conservative therapies, age, and severity of urinary symptoms, and examine for a correlation with urinary symptom resolution with either SNM therapy or combined therapy.
timeFrame: Retrospective chart review
Other outcomes:
Locations:
city: Orange
country: United States
facility: UCI Women's Healthcare
state: California
Study officials:
affiliation: UCI Medical Center
name: Karen Noblett, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT00741546: Association of Low Vitamin D Levels With Mortality in Patients With Reduced Left Ventricular Function Referred to Cardiac Surgery
Official title: Association of Low Vitamin D Levels With Mortality in Patients With Reduced Left Ventricular Function Referred to Cardiac Surgery
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Malnutrition
Keywords: Vitamin D
malnutrition
cardiac surgery
study
emphasize
importance
significant
high risk patient
Lead sponsor: Johann Wolfgang Goethe University Hospital
Sponsor class: OTHER
First posted: 2008-08-26
Enrollment: 160
Sex: ALL
Minimum age (years): 18
Maximum age (years): 80
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: CASE_CONTROL
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: Patients admitted for cardiac surgery intervention

Brief summary: This study investigates if reduced serum levels of vitamin D concentration are a typical feature in patient group with low left ventricular function admitted for cardiac surgery interventions. and also the necessity of more preventive strategies for adequate nutrition of these patients with more focus on intake of vitamin D before admission to cardiac surgery.


Eligibility criteria: Inclusion Criteria:

* All routinely cardiac procedures

Exclusion Criteria:

* dialysis, cancer

Primary outcomes:
measure: Perioperative mortality
timeFrame: 90day
Secondary outcomes:
Other outcomes:
Locations:
city: Frankfurt am Main
country: Germany
facility: Department of Thoracic and Cardiovascular Surgery
state: Hessen
Study officials:
References:
Clinical trial NCT01102946: Panretinal Photocoagulation (PRP) Plus Ranibizumab for Proliferative Diabetic Retinopathy
Official title: Panretinal Photocoagulation Versus Panretinal Photocoagulation Plus Intravitreous Ranibizumab for High Risk Proliferative Diabetic Retinopathy
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE2
Conditions: Diabetic Retinopathy
Retinal Neovascularization
Keywords: proliferative diabetic retinopathy
retinal neovascularization
Angiogenesis Inhibitors
ranibizumab
laser
Lead sponsor: University of Sao Paulo
Sponsor class: OTHER
First posted: 2010-04-13
Enrollment: 40
Sex: ALL
Minimum age (years): 18
Maximum age (years): 80
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The purpose of this study is to evaluate the effects of panretinal photocoagulation plus intravitreal ranibizumab for the treatment of patients with high risk proliferative diabetic retinopathy in terms of changes in visual acuity and neovascularization area.


Eligibility criteria: Inclusion Criteria:

* Age ≥ 18 years old
* High risk proliferative diabetic retinopathy
* Visual acuity ≥ 20/800
* No previous laser treatment for diabetic retinopathy

Exclusion Criteria:

* Previous pars plana vitrectomy
* Systemic thrombo-embolic events
* Uncontrolled systemic hypertension
* Conditions avoiding adequated documentation
* Previous eye surgery in the last 6 months before inclusion in the study

Primary outcomes:
measure: Fluorescein leakage area (mm2)
timeFrame: Week 48 after inclusion in the study
Secondary outcomes:
measure: CMT
timeFrame: Week 48 after inclusion in the study
measure: LogMAR BCVA
timeFrame: Week 48 after inclusion in the study
measure: Retina mid periphery visual field sensitivity change
timeFrame: Week 48 after inclusion in the study
measure: Rod pathway integrity and oscillatory potential amplitudes
timeFrame: Week 48 after inclusion in the study
Other outcomes:
Locations:
city: Ribeirao Preto
country: Brazil
facility: University of São Paulo
state: Sao Paulo
Study officials:
References:
Clinical trial NCT05512546: The Prevention of Thromboembolic Complications Associated With Coil Embolization
Official title: Coil Embolization and Thromboembolic Complications in Patients With Ruptured Aneurysms
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Thromboembolic Stroke
Aspirin
Clopidogrel
Coil Embolization
Prevention
Lead sponsor: Shaheed Zulfiqar Ali Bhutto Medical University
Sponsor class: OTHER
First posted: 2022-08-23
Enrollment: 200
Sex: ALL
Minimum age (years): 45
Maximum age (years): 80
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: CASE_CONTROL
Time perspective: RETROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: patients with ruptured cerebral hemorrhage

Brief summary: Clopidogrel has been to be reported to be superior to aspirin for the prevention of thromboembolic complications associated with coil embolization in patients with ruptured aneurysms.


Eligibility criteria: Inclusion Criteria:

* All the patients enrolled in the study underwent MRI and Angiography.
* Participants included in the study were confirmed on assessment, and verified for ruptured aneurysm by imaging using either computed tomography (CT) or MRI.

Exclusion Criteria:

* Patients with any history of sensitivity or reaction to aspirin, or any contraindication for MRI, were excluded from the study.

Primary outcomes:
measure: High Intensity Areas
timeFrame: at 24 hours
measure: High Intensity Areas
timeFrame: 3 months
Secondary outcomes:
measure: High Intensity Areas
timeFrame: at 6 months
Other outcomes:
Locations:
city: Lahore
country: Pakistan
facility: Umair Rasheed
state: Punjab
Study officials:
affiliation: Lahore General Hospital
name: Umair Rasheed, FRCPS
role: STUDY_DIRECTOR
References:
Clinical trial NCT00489346: A Study to Evaluate MK0476 and Fluticasone to Control Asthma in Patients With Mild Persistent Asthma (0476-910)
Official title: A Double-Blind, Randomized, Double-Dummy, Multicenter Study to Evaluate and Compare Oral Montelukast and Inhaled Fluticasone in the Control of Asthma for 6- to 14-Year-Olds With Mild Persistent Asthma
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE3
Conditions: Asthma, Bronchial
Lead sponsor: Organon and Co
Sponsor class: INDUSTRY
First posted: 2007-06-21
Enrollment: 994
Sex: ALL
Minimum age (years): 6
Maximum age (years): 14
Standard ages: CHILD
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: A study to evaluate MK0476 and Fluticasone to control asthma in patients with mild persistent asthma.


Eligibility criteria: Inclusion Criteria:

* Patient is male or female, 6-14 years of age with mild persistent asthma
* Patient has a history of the following symptoms: wheezing, chest tightness, cough, etc.
* Patient has asthma diagnosed by a doctor

Exclusion Criteria:

* Patient is hospitalized
* Patient has had major surgery or participated in another clinical trial in the last 4 weeks
* Patient has been on a breathing tube for asthma

Primary outcomes:
measure: Improvement of asthma with MK0476 and Fluticasone as measured by number of asthma rescue-free days
timeFrame: Duration of Trial
Secondary outcomes:
measure: Improved effect of MK0476 and fluticasone on FEV1 values
timeFrame: Duration of Trial
Other outcomes:
Locations:
Study officials:
affiliation: Merck Sharp & Dohme LLC
name: Medical Monitor
role: STUDY_DIRECTOR
References:
citation: Garcia Garcia ML, Wahn U, Gilles L, Swern A, Tozzi CA, Polos P. Montelukast, compared with fluticasone, for control of asthma among 6- to 14-year-old patients with mild asthma: the MOSAIC study. Pediatrics. 2005 Aug;116(2):360-9. doi: 10.1542/peds.2004-1172.
Clinical trial NCT02873546: tDCS Effect on Cognitive Functions From Patients With Alzheimer's Disease or Progressive Primary Aphasia
Official title: Evaluation de l'Effet de la tDCS Sur Les Fonctions Cognitives de Patients Souffrant de Maladie d'Alzheimer et Maladies apparentées au Stade léger
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Alzheimer's Disease
Progressive Primary Aphasia
Early or Mild State
Lead sponsor: Centre Hospitalier Universitaire de Besancon
Sponsor class: OTHER
Collaborators: name: Centre Hospitalier Universitaire Dijon
name: Assistance Publique - Hôpitaux de Paris
First posted: 2016-08-19
Enrollment: 52
Sex: ALL
Minimum age (years): 60
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The purpose of this study is to evaluate the effect of 10 sessions of anodal transcranial Direct Current Stimulation (tDCS - 1 mA) applied to left Cortex DorsoLateral PreFrontal (CDLPF) of Alzheimer's or Primary Progressive Aphasia (PPA) patients compared to the application of a placebo tDCS (sham procedure) on cognitive functions, which are evaluated at short term (1 week post-treatment) and mild term (3 weeks post-treatment).

After unblinding, patients who received placebo treatment could be received active tDCS.


Eligibility criteria: Inclusion Criteria:

* National Institute of Neurological and Communicative Disorders and Stroke and the Alzheimer's Disease and Related Disorders Association (NINCDS-ADRADA) criteria (Alzheimer's patient) OR Gordo-Tempini criteria (PPA's patient)
* CDR score ≤ 2
* treatment by IAChE ≥ 3 months
* MADRS score \< 18
* w/o severe progressive somatic pathology (especially tumor diseases)

Exclusion Criteria:

* last neuropsychological assessment \< 6 months
* presence of a specific contraindication for tDCS (e.g. personal history of epilepsy, metallic head implant, cardiac pacemaker)

Primary outcomes:
measure: change from baseline cognitive functions at 3 weeks
timeFrame: baseline, day 5 and 3 weeks post-tDCS
Secondary outcomes:
Other outcomes:
Locations:
city: Besancon
country: France
facility: CHU Besancon - Clinical Psychiatric Department
city: Dijon
country: France
facility: Hopital Universitaire Dijon
city: Paris
country: France
facility: Assistance Publique - Hôpitaux Paris
Study officials:
affiliation: Assitance Publique - Hôpitaux Paris
name: Claire Paquet, MD PhD
role: PRINCIPAL_INVESTIGATOR
affiliation: Centre Hospitalier Universaitaire Dijon
name: Bernard Bonnin, MD PhD
role: PRINCIPAL_INVESTIGATOR
References:
citation: Bereau M, Sylvestre G, Mauny F, Puyraveau M, Baudier F, Magnin E, Berger E, Vandel P, Galmiche J, Chopard G. [Assessment of 10 years of memory consultations in the Franche-Comte: Description and analysis of the RAPID regional database]. Rev Neurol (Paris). 2015 Sep;171(8-9):655-61. doi: 10.1016/j.neurol.2015.04.008. Epub 2015 Jul 23. French.
Clinical trial NCT04337346: Evaluation of Covid 19 Anxiety in Endometriosis Patients
Official title: Endometriosis Patients Covid 19 Anxiety
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Endometriosis
Covid19
Lead sponsor: Kanuni Sultan Suleyman Training and Research Hospital
Sponsor class: OTHER
First posted: 2020-04-07
Enrollment: 80
Sex: FEMALE
Minimum age (years): 18
Maximum age (years): 45
Standard ages: ADULT
Accepts healthy volunteers: yes
Observational model: CASE_CONTROL
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: Evaluation of endometriosis patients anxiety and lifestyle during the covid 19 pandemic

Brief summary: It is aimed to measure the general anxiety and lifestyle information of endometriosis patients about covid 19 pandemic, to evaluate anxiety levels in this period.


Eligibility criteria: Inclusion Criteria:

* endometriosis patients
* no psychiatric illness
* no antidepressant use

Exclusion Criteria:

* women who had not endometriosis
* no extra health conditions
* women younger than 18 and older than 45

Primary outcomes:
measure: Covid 19 Anxiety levels in Endometriosis Patients
timeFrame: 20 days
Secondary outcomes:
Other outcomes:
Locations:
city: Istanbul
country: Turkey
facility: Pinar Yalcin Bahat
state: İ̇stanbul
Study officials:
References: