Clinical trial NCT05799911: Effect of Molecular Hydrogen Administration on Performance and Body Response on Exercise in National-level Fin-swimmers
Official title: Effect of Molecular Hydrogen Administration on Performance and Body Response on Repeated Exercise and the Following Recovery in National-level Fin-swimmers: A Randomized, Double-blind, Placebo-controlled Crossover Trial
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Athletic Performance
Muscle Fatigue
Oxidative Stress
Lead sponsor: Palacky University
Sponsor class: OTHER
First posted: 2023-04-05
Enrollment: 14
Sex: ALL
Minimum age (years): 16
Maximum age (years): 30
Standard ages: CHILD
ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: CROSSOVER
Primary purpose: PREVENTION

Brief summary: The aim of this randomized, double-blind, placebo-controlled crossover trial is to evaluate the effect of hydrogen-rich water consumption on performance, recovery, psychological and biochemical outcomes in elite Czech fin-swimmers.

Detailed description: Twelve Czech national and international-level fin-swimmers participate in this trial. Participants take molecular hydrogen via drinking hydrogen-rich water (HRW) or placebo three days before (1260 ml/day) and during testing day (2520 ml). All participants participate in two testing session and receive HRW and placebo in random order. Each session includes two training units in a 25-m indoor swimming pool and a 24-hour monitored recovery. The first training unit takes place in the morning between 9 and 11 AM and includes three high intensity interval sets. The afternoon training unit includes a continuous 400-m competitive performance. The washout period between testing sessions is 7 days. The variables assessed are as follows: swimming times, heart rate variability, lower limb explosive strength, rating of perceived exertion, subjective perceived muscle soreness, creatine kinase, blood lactate, and protein carbonyls. Statistical analysis is based on analysis of variance for repeated measures with factors: water (HRW and placebo), time, and interaction. Fisher's post-hoc tests is used for pairwise comparisons. The significance level is set at 0.05.

Eligibility criteria: Inclusion Criteria:

* Junior or adult Czech fin-swimming representative.
* Medical eligibility for competitive sport.
* Good health condition.
* Signed informed consent.

Exclusion Criteria:

* Acute health problems.
* Not following instructions (free of any supplements three weeks before experiment, free of any medicaments, no caffeine at least 24 hours before experiment).
* Menstruation in testing session.

Primary outcomes:
measure: Swimming time for 400 m
timeFrame: Change between values before and after 7 days of crossover.
Secondary outcomes:
measure: Swimming time for 50 m
timeFrame: Change between values before and after 7 days of crossover.
measure: Heart rate variability
timeFrame: Change between values before and after 7 days of crossover.
measure: Lower limb explosive strength
timeFrame: Change between values before and after 7 days of crossover.
measure: Rating of perceived exertion
timeFrame: Change between values before and after 7 days of crossover.
measure: Subjective perceived muscle soreness
timeFrame: Change between values before and after 7 days of crossover.
measure: Creatine kinase
timeFrame: Change between values before and after 7 days of crossover.
measure: Blood lactate
timeFrame: Change between values before and after 7 days of crossover.
measure: Protein carbonyls
timeFrame: Change between values before and after 7 days of crossover.
Other outcomes:
Locations:
city: Olomouc
country: Czechia
facility: Palacky University, Faculty of Physical Culture
Study officials:
affiliation: Palacky University
name: Barbora Sladeckova, MSc
role: PRINCIPAL_INVESTIGATOR
References:
citation: Botek M, Krejčí J, Sládečková B, McKune A. Autonomic cardiac regulation in response to exercise and molecular hydrogen administration in well-trained athletes. In: Slezak J, Kura B, eds. Molecular Hydrogen in Health and Disease. Springer Nature Switzerland; 2024:69-91. doi:10.1007/978-3-031-47375-3_5
citation: Sladeckova B, Botek M, Krejci J, Valenta M, McKune A, Neuls F, Klimesova I. Hydrogen-rich water supplementation promotes muscle recovery after two strenuous training sessions performed on the same day in elite fin swimmers: randomized, double-blind, placebo-controlled, crossover trial. Front Physiol. 2024 Apr 12;15:1321160. doi: 10.3389/fphys.2024.1321160. eCollection 2024.