louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT01075932: Effects of Docosahexaenoic Acid (DHA)-Rich Fish Oil on Cerebral Haemodynamics
Official title: The Cognitive And Cerebral Hemodynamic Effects Of DHA-Rich Fish Oil: A Dose-Ranging Study
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Cerebral Blood Flow
Cognitive Function
Keywords: cerebral blood flow
NIRS
n-3 PUFAs
fish oil
cognitive function
Lead sponsor: Northumbria University
Sponsor class: OTHER
Collaborators: name: Ginsana SA
First posted: 2010-02-25
Enrollment: 65
Sex: ALL
Minimum age (years): 18
Maximum age (years): 35
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: BASIC_SCIENCE

Brief summary: DHA has previously been shown to increase regional cerebral blood flow response to tactile stimulation in aged monkeys; modulation of cerebral blood flow in humans has yet to be demonstrated. Given that the brain relies on a constant supply of blood-borne metabolic substrates (e.g. glucose, oxygen), increasing regional cerebral blood flow may also have an impact on cognitive function. The current study aims to investigate the effects of two doses of DHA-rich fish oil on task-related cerebral hemodynamic response and cognitive performance in healthy adults.


Eligibility criteria: Inclusion Criteria:

* Male/Female
* 18-35 years
* Healthy
* No herbal supplements/prescription medications (excl. contraceptive pill)
* Non smoker
* Native English speaker

Exclusion Criteria:

* consumes oily fish
* takes omega-3 supplement
* food allergies to treatment ingredients

Primary outcomes:
measure: Cerebral blood flow
timeFrame: 12 weeks
Secondary outcomes:
measure: Cognitive function
timeFrame: 12 weeks
Other outcomes:
Locations:
city: Newcastle upon Tyne
country: United Kingdom
facility: Northumbria University
state: Tyne and Wear
Study officials:
affiliation: Northumbria University
name: Philippa A Jackson
role: PRINCIPAL_INVESTIGATOR
References:
citation: Jackson PA, Reay JL, Scholey AB, Kennedy DO. Docosahexaenoic acid-rich fish oil modulates the cerebral hemodynamic response to cognitive tasks in healthy young adults. Biol Psychol. 2012 Jan;89(1):183-90. doi: 10.1016/j.biopsycho.2011.10.006. Epub 2011 Oct 19.
Clinical trial NCT06871332: Progressive Relaxation Exercise on Pain, Anxiety and Patient Satisfaction
Official title: The Effect of Progressive Relaxation Exercise on Pain, Anxiety and Patient Satisfaction Related to Femoral Sheath Removal: a Randomized Controlled Study
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Effect of Progressive Relaxation Exercise
Keywords: Anxiety
Femoral Sheath
Pain
Progressive Relaxation Exercise
Satisfaction
Lead sponsor: TC Erciyes University
Sponsor class: OTHER
First posted: 2025-03-11
Enrollment: 70
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: SUPPORTIVE_CARE

Brief summary: This single-center, prospective, randomized controlled trial was completed with a total of 70 patients, 35 in each of the intervention and control groups. Data were collected using the Patient Information Form, Visual Analogy Scale and State-Trait Anxiety Inventory. Patients in the intervention group performed progressive relaxation exercise for 20 minutes before femoral sheath removal. The patients in the control group received the standard practice of the clinic.

Detailed description: This study aimed to determine the effect of progressive relaxation exercise (PRE) applied to patients undergoing percutaneous coronary intervention (PCI) on pain, anxiety and patient satisfaction related to femoral sheath removal. This single-center, prospective, randomized controlled trial was completed with a total of 70 patients, 35 in each of the intervention and control groups. Data were collected using the Patient Information Form, Visual Analogy Scale and State-Trait Anxiety Inventory. Patients in the intervention group performed PRE for 20 minutes before femoral sheath removal. The patients in the control group received the standard practice of the clinic.

Eligibility criteria: Inclusion Criteria:

* able to speak and understand Turkish,
* over 18 years of age,
* intervened in the femoral region,
* with only one catheter in the femoral region,
* without vision and hearing problems,
* undergoing angiography procedure for the first time,
* with normal vital signs,
* who have not been administered analgesics for any reason prior to sheath removal after the procedure,
* patients who volunteered to participate in the study were included in the study.

Exclusion Criteria:

* patients with chronic pain using transdermal patches,
* patients with impaired time and place orientation,
* patients with psychiatric disorders.

Primary outcomes:
measure: Pain level
timeFrame: One minute after femoral sheath removal
measure: Anxiety level
timeFrame: One minute after femoral sheath removal
measure: Patient satisfaction
timeFrame: One minute after sheath removal
Secondary outcomes:
Other outcomes:
Locations:
city: Talas
country: Turkey
facility: Erciyes University
state: Kayseri
Study officials:
References:
Clinical trial NCT04115332: The Effects of Resilience and Mental Health of Abused Psychiatric Nurses: An Intervention With Biofeedback Training
Official title: 精神科受暴護理人員復原力與心理健康之成效-以生理回饋訓練為介入措施 The Effects of Resilience and Mental Health of Abused Psychiatric Nurses: An Intervention With Biofeedback Training
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Psychiatric Nurses, Workplace Violence, Biofeedback Training, and Resilience
Keywords: psychiatric nurses
workplace violence
resilience
biofeedback training
physiological indicators
Lead sponsor: Kaohsiung Medical University Chung-Ho Memorial Hospital
Sponsor class: OTHER
First posted: 2019-10-04
Enrollment: 136
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: SUPPORTIVE_CARE

Brief summary: The investigators provide biofeedback training to assist the abused PW nurses to reduce WPV-related stress and achieve better resilience and mental health. The research project will assess the participants' physiological indices prior to the intervention as well as their levels of resilience and mental status.

Detailed description: This was a quasi-experimental study, structured questionnaires of Resilience Score, The Center for Epidemiologic Studies Depression (CES-D) and Occupational Stress Indicator-2 were used in this study before and three months after intervention. A total of 112 abused psychiatric nurses were randomly assigned to 3 groups. The biofeedback group (n=40) received the biofeedback training and the self-training group received video relaxation training by Line (n=44). The control group (n=28) did not receive any intervention.

Biofeedback training is an effective intervention to enhance abused PW nurses' resilience and lower their depressive symptoms. Video relaxation self-training is also an effective way to strengthen abused psychiatric nurses' resilience.

Eligibility criteria: Inclusion Criteria:

* abused psychiatric ward (PW) nurses

Exclusion Criteria:

-

Primary outcomes:
measure: The Center for Epidemiologic Studies Depression
timeFrame: 15 minutes
measure: The Resilience
timeFrame: 15 minutes
Secondary outcomes:
measure: EEG
timeFrame: 5 minutes
measure: Heart rate
timeFrame: 5 minutes
Other outcomes:
Locations:
city: Kaohsiung
country: Taiwan
facility: Kaohsiung Medical University
Study officials:
References:
Clinical trial NCT04679532: NBA G-League Sweat Testing Study: Validity of the Gx Sweat Patch in Measuring Sweating Rate and Sweat Chloride Concentration During On-court Training With Basketball Players
Official title: NBA G-League Sweat Testing Study: Validity of the Gx Sweat Patch in Measuring Sweating Rate and Sweat Chloride Concentration During On-court Training With Basketball Players
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Sweat Analysis
Keywords: sweating rate
sweat electrolytes
sweat electrolyte concentration
sweat patch
wearable
epidermal
Gx patch
Lead sponsor: PepsiCo Global R&D
Sponsor class: INDUSTRY
First posted: 2020-12-22
Enrollment: 65
Sex: MALE
Minimum age (years): 18
Maximum age (years): 40
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: NON_RANDOMIZED
Intervention model: SINGLE_GROUP
Intervention model description: Each subject serves as their own control. Both devices are worn during the same exercise session.
Primary purpose: BASIC_SCIENCE

Brief summary: To determine the validity of the Gx Sweat Patch in measuring sweating rate and sweat chloride concentration during moderate-high intensity practice against well-established reference methods in field conditions with basketball athletes


Eligibility criteria: Inclusion Criteria:

* 18-40 years of age
* Subject is participating in training/competition with the NBA G-league
* Subject is participating in a coach led practice

Exclusion Criteria:

* Subject has an allergy to adhesives (e.g., experiences rash reactions to typical adhesive bandages)
* Subject has participated in a clinical trial within past 30 days
* Subject has participated in any PepsiCo trial within past 6 months
* Subject has a condition the investigator believes would interfere with his/her ability to provide informed consent, comply with the study protocol, which might confound the interpretation of the study results or put the person at undue risk

Primary outcomes:
measure: Regional sweat chloride concentration
timeFrame: Average across a single practice session on 1 day
Secondary outcomes:
measure: Regional sweating rate
timeFrame: Average across the same single practice session on the same 1 day as the primary outcome
measure: Whole body sweating rate
timeFrame: Measured one time to represent the average across the same single practice session on the same 1 day as the primary outcome
Other outcomes:
Locations:
city: Walnut Creek
country: United States
facility: NBA G League Ignite Team Site Ultimate Fieldhouse, 2675 Mitchell Dr.
state: California
Study officials:
affiliation: PepsiCo Global R&D, Gatorade Sports Science Institute (GSSI) Barrington, IL
name: Lindsay B Baker, PhD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT00623532: Intervention Study of Mind-Body Physical Activity in Frail Institutionalized Elderly
Official title: A Randomized Interventional Study of a Cognition-Action Physical Activity and Adapted Tai-Chi in Frail Institutionalized Elderly
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Aging
Frailty
Keywords: Tertiary prevention of disability
Lead sponsor: Association de Recherche Gerontologique
Sponsor class: OTHER
Collaborators: name: Conseil Régional d'Aquitaine (France)
First posted: 2008-02-26
Enrollment: 160
Sex: ALL
Minimum age (years): 65
Standard ages: OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: FACTORIAL
Primary purpose: PREVENTION

Brief summary: Few previous studies have explored the effects of mind body approaches on health-related quality of life (HRQoL) in frail elderly. Cognition and action are an inseparable whole while functioning. A new intervention-based approach using familiarity based movements and a non-judgmental approach was labeled "cognition-action." The investigators aimed to explore the effects of two different mind-body exercise types on (HRQoL) in frail institutionalized elderly.

The investigators' main hypothesis is that adaptated physical activity in frail institutionalized elderly can improve HRQoL.


Eligibility criteria: Inclusion Criteria:

* Aged 65 and older
* Institutionalized
* Ability to get up alone or with technical or human help if necessary and ability to understand basic motor commands
* Have given a signed consent

Exclusion Criteria:

* Terminally ill and bedridden patients
* Unable or unwilling to sign the consent
* Have participated in a study in the past 3 month

Primary outcomes:
measure: MOS SF-12
Secondary outcomes:
measure: Timed Up and Go test
Other outcomes:
Locations:
city: Bordeaux
country: France
facility: Hopital Xavier Arnozan, CHU de Bordeaux
state: Gironde
Study officials:
References:
citation: Dechamps A, Diolez P, Thiaudiere E, Tulon A, Onifade C, Vuong T, Helmer C, Bourdel-Marchasson I. Effects of exercise programs to prevent decline in health-related quality of life in highly deconditioned institutionalized elderly persons: a randomized controlled trial. Arch Intern Med. 2010 Jan 25;170(2):162-9. doi: 10.1001/archinternmed.2009.489.
Clinical trial NCT06317532: Effect of Functional Exercises on Pain and Quality of Life in Females With Primary Dysmenorrhea
Official title: Effect of Functional Exercises on Pain and Quality of Life in Females With Primary Dysmenorrhea
Study type: INTERVENTIONAL
Overall status: NOT_YET_RECRUITING
Phase: NA
Conditions: Primary Dysmenorrhea
Keywords: Primary Dysmenorrhea
Functional Exercises
Pain
Quality of Life
Lead sponsor: Cairo University
Sponsor class: OTHER
First posted: 2024-03-19
Enrollment: 58
Sex: FEMALE
Minimum age (years): 18
Maximum age (years): 25
Standard ages: ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The aim of the study will be to investigate the effect of functional exercises on pain and quality of life in females with primary dysmenorrhea.

Detailed description: Primary dysmenorrhea and menstrual pain are significant health, social and economic problems. It involves a broad spectrum of physical and emotional manifestations, with 50% to 91 % prevalence in young women.

Women with primary dysmenorrhea report significantly lower quality of life because of bodily pain, general health condition, and physical and social functioning. It compromises the most common gynecological alternations and is the primary cause of women's academic and work absenteeism, which reduces the quality of life, daily activities, and economic situation due to decreased working hours.

Non-Steroidal Anti-Inflammatory Drugs are the first therapeutic line for primary dysmenorrhea; however, they might be accompanied by undesirable side effects, such as dyspepsia, headache, and drowsiness.

So, there is a need for safe interventions with no side effects. Therefore, this study aims to investigate the effects of functional exercises on pain and quality of life in females with primary dysmenorrhea.

Eligibility criteria: Inclusion Criteria:

1. Their ages will be ranged from 18 to 25 years
2. They will be suffering from primary dysmenorrhea based on the Menstrual Distress questionnaire.
3. Their BMI will be ranged from 20 to 25 kg/m2.
4. Having regular menstrual cycles (one every 28-34 days).
5. They will be sedentary virgin females.
6. They are non-smokers.
7. They have not been in any exercise program for three months.

Exclusion Criteria:

1. Having secondary dysmenorrhea.
2. Using regular medication or contraceptive pills.
3. Having neuromuscular, metabolic, or cardiac diseases.
4. Having a preexisting condition prevents them from engaging in an exercise program.

Primary outcomes:
measure: Visual analogue scale (VAS)
timeFrame: 8 weeks
measure: The Menstrual Distress Questionnaire
timeFrame: 8 weeks
Secondary outcomes:
measure: Quality of life enjoyment and satisfaction questionnaire
timeFrame: 8 weeks
measure: Pressure pain threshold assessment
timeFrame: 8 weeks
Other outcomes:
Locations:
city: Giza
country: Egypt
facility: Cairo University
Study officials:
References:
Clinical trial NCT01515332: Energy Expenditure Methodology
Official title: Energy Expenditure Methodology
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Healthy Adults
Lead sponsor: Arkansas Children's Hospital Research Institute
Sponsor class: OTHER
First posted: 2012-01-24
Enrollment: 15
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: healthy adults from the surrounding community

Brief summary: This study is simply to test the repeatability of the indirect calorimetry instrument the investigators use for our clinical studies.

Detailed description: Participants will be required to attend two study visits at the Arkansas Children's Nutrition Center. During the first visit, informed consent will be obtained, participant will be measured and an indirect calorimetry assessment to measure resting energy expenditure will be performed. During the second visit, we will repeat the indirect calorimetry assessment to measure resting energy expenditure.

Eligibility criteria: Inclusion Criteria:

* 18 years of age or older

Exclusion Criteria:

* pulmonary or respiratory disorders

Primary outcomes:
measure: repeatability of test results
timeFrame: 2-3 hours up to 2-3 days
Secondary outcomes:
Other outcomes:
Locations:
city: Little Rock
country: United States
facility: Arkansas Children's Nutrition Center
state: Arkansas
Study officials:
References:
Clinical trial NCT04582032: Effects of Cyclooxygenase (COX) 1-2 Inhibitors on Prevention of Rocuronium Injection Pain
Official title: Effects of COX 1-2 Inhibitors on Prevention of Rocuronium Injection Pain: Controlled, Randomised, Double Blind Study
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Injection Site Irritation
Keywords: dexketoprofen, pain, rocuronium
Lead sponsor: Ankara City Hospital Bilkent
Sponsor class: OTHER
First posted: 2020-10-09
Enrollment: 68
Sex: ALL
Minimum age (years): 18
Maximum age (years): 60
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: PREVENTION

Brief summary: Purpose : The aim of the study is to investigate the effects of cox inhibitors as a rescue agent against the rocuronium pain Methodology : Sixty patients enrolled for the general anesthesia enrolled in this study. Patients were allocated into two groups (Group 1: Dexketoprofen group, Group 2: Control group) .Pain was evaluated by during rocuronium injection, patients were scored by a scale showed below.

0;No movement response to injection

1. Mild movement response to injection
2. Hand withdrawal response to injection
3. Arm withdrawal response to injection Investigators also evaluated the pain with 2 questions when the patient was in the recovery room.

Question 1.What was the last feeling before participants fall into sleep? question 2. Did participants feel any pain on participants's hand during medication injection for anesthesia?

Detailed description: Purpose : Rocuronium bromide is a painful agent while general anesthesia induction. The aim of the study is to investigate the effects of cox inhibitors as a rescue agent against the rocuronium pain Methodology : Sixty patients enrolled for the general anesthesia enrolled in this study. Patients were allocated into two groups (Group 1: Dexketoprofen group, Group 2: Control group) .Pain was evaluated by during rocuronium injection, patients were scored by a scale showed below.

0;No movement response to injection

1. Mild movement response to injection
2. Hand withdrawal response to injection
3. Arm withdrawal response to injection Investigators also evaluated the pain with 2 questions when the patient was in the recovery room.

Question 1.What was the last feeling before participants fall into sleep? question 2. Did participants feel any pain on participants's hand during medication injection for anesthesia?

Eligibility criteria: Inclusion Criteria:

* non allergic to dexketoprofen
* 18-60 years old
* American Society of Anesthesiologists(ASA) 1-2-3
* 70-90 kg weigh

Exclusion Criteria:

* patients with psychiatric and mental problems

Primary outcomes:
measure: The injection pain due to rocuronium
timeFrame: 1 month
Secondary outcomes:
measure: Score on pain due to injection of rocuronium
timeFrame: 1 month
Other outcomes:
Locations:
city: Ankara
country: Turkey
facility: Kecioren Training and Research Hospital
Study officials:
References:
Clinical trial NCT03558932: IP3R Modulation by Cancer Genes in Mesothelioma
Official title: IP3R Modulation by Cancer Genes Bcl-2 & PKM2 in Mesothelioma
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Malignant Mesothelioma
Lead sponsor: KU Leuven
Sponsor class: OTHER
First posted: 2018-06-15
Enrollment: 20
Sex: ALL
Minimum age (years): 18
Maximum age (years): 89
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: mesothelioma

Brief summary: Obtaining pleural biopsies in cases of malignant mesothelioma to detect molecular mechnisms and signal transduction


Eligibility criteria: Inclusion Criteria:

* suspicion of mesothelioma
* referral for diagnostic thoracoscopy

Exclusion Criteria:

* contra-indication for thoracoscopy

Primary outcomes:
measure: Pleural biopsy
timeFrame: 5 years
Secondary outcomes:
Other outcomes:
measure: Immunoblotting
timeFrame: 5 years
measure: Cytometric analysis (FACS-based approaches)
timeFrame: 5 years
measure: Live cell imaging for Ca2+-signaling
timeFrame: 5 years
Locations:
Study officials:
affiliation: Catholic university Leuven
name: Jonas Yserbyt
role: PRINCIPAL_INVESTIGATOR
References: