louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT06982989: Clinical Study on the Treatment of Pelvic Pain With Wearable Dual-band LED Device
Official title: Clinical Study on the Treatment of Pelvic Pain With Wearable Dual-band LED Device
Study type: INTERVENTIONAL
Overall status: RECRUITING
Phase: NA
Conditions: Pelvic Pain
Keywords: LED
pelvic pain
Lead sponsor: Peking University Third Hospital
Sponsor class: OTHER
First posted: 2025-05-21
Enrollment: 250
Sex: FEMALE
Minimum age (years): 18
Maximum age (years): 35
Standard ages: ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: TREATMENT

Brief summary: This study is a prospective clinical trial, which intends to prospective include female pelvic pain (dysmenorrhea and chronic pelvic pain), screen suitable cases, wear dual-band LED devices in non-menstrual period, perform low-dose phototherapy on local pelvic area and acupoints, and observe the changes of pelvic pain and related serological indicators in clinical practice.


Eligibility criteria: Inclusion Criteria:

* pelvic pain

Exclusion Criteria:

* Irregular menstrual cycles;
* Inflammatory disease;
* pregnant;
* Light allergy;

Primary outcomes:
measure: Efficacy that LED release pelvic pain
timeFrame: 1 month after the treatment
Secondary outcomes:
Other outcomes:
Locations:
city: Beijing
country: China
facility: Peking Unniversity Third Hospital
state: Beijing
Study officials:
References:
Clinical trial NCT00108589: S-Adenosylmethionine Therapy for Non-Alcoholic Steatohepatitis
Official title: S-Adenosylmethionine Therapy for Non-Alcoholic Steatohepatitis
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE3
Conditions: Hepatitis
Keywords: s-adenosylmethionine
fatty liver
obesity
Non-alcoholic steatohepatitis
Lead sponsor: VA Office of Research and Development
Sponsor class: FED
First posted: 2005-04-18
Sex: MALE
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: SINGLE_GROUP
Primary purpose: TREATMENT

Brief summary: The purpose of this study is to examine the effect of S-adenosylmethionine therapy in those patients with non-alcoholic liver disease in the form of steatohepatitis (NASH). This will be accomplished by development of a database of these patients, all of whom will have biopsy documented NASH. A placebo controlled trial will then examine the effect of S-adenosylmethionine over time on clinical outcome in these patients. It is expected that this agent will slow or halt the progression of this disease.


Eligibility criteria: Inclusion Criteria:

* Men with biopsy proven non-alcoholic steatohepatitis from the liver disease clinic or referred from other physicians from the VAMC-Louisville.

Primary outcomes:
Secondary outcomes:
Other outcomes:
Locations:
city: Louisville
country: United States
facility: VA Medical Center
state: Kentucky
Study officials:
References:
Clinical trial NCT02065089: Development of 'Emma'--a Pediatric IBD Quiz
Official title: Development of an Electronic Pediatric Inflammatory Bowel Disease Quiz
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Ulcerative Colitis
Crohn's Disease
Inflammatory Bowel Disease
Lead sponsor: Mayo Clinic
Sponsor class: OTHER
First posted: 2014-02-17
Enrollment: 116
Sex: ALL
Minimum age (years): 10
Maximum age (years): 18
Standard ages: CHILD
ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: HEALTH_SERVICES_RESEARCH

Brief summary: We would like to collaborate and further develop an ipad-based, interactive quiz game 'Emma'; to identify gaps in knowledge of inflammatory bowel disease in pediatric patients. These gaps can be used to improve patient education.


Eligibility criteria: Inclusion Criteria:

* Children 10-18 years of age
* Diagnosis of Crohn's disease or ulcerative colitis
* English-speaking
* Established patient of participating institution

Exclusion criteria

* Inability to understand and read English at a grade 5-12 year level, as commensurate to their chronological age
* Research denial by patient or guardian

Primary outcomes:
measure: Improvement in patient knowledge of inflammatory bowel disease
timeFrame: baseline to 18 months
Secondary outcomes:
Other outcomes:
Locations:
city: Rochester
country: United States
facility: Mayo Clinic in Rochester
state: Minnesota
city: Oklahoma City
country: United States
facility: Oklahoma University Medical Center
state: Oklahoma
Study officials:
affiliation: Mayo Clinic
name: Jeanne Tung, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT01070589: The Effect of Obesity on Growth Hormone Response to Anaerobic Exercise
Official title: The Effect of Obesity on Growth Hormone Response to Anaerobic Exercise
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Obesity
Keywords: Obesity
Growth hormone secretion
Anaerobic exercise
Lead sponsor: Meir Medical Center
Sponsor class: OTHER
First posted: 2010-02-18
Enrollment: 24
Sex: FEMALE
Minimum age (years): 18
Maximum age (years): 40
Standard ages: ADULT
Accepts healthy volunteers: yes
Observational model: CASE_CONTROL
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: Healthy female Age 18-40 years

Brief summary: The aim of the present study is to asses the effect of obesity on anaerobic exercise's growth hormone (GH) response.

Detailed description: Exercise is a potent physiological stimulator of growth hormone (GH) release. GH is an important factor in the distribution of fat and lean tissue in the body. Previous studies suggested that the GH response to aerobic exercise may be attenuated by obesity. The effect of obesity on GH response to anaerobic effort is unclear. The aim of the present study is to asses the effect of obesity on anaerobic exercise's GH response. We will recruit 12 obese (BMI \> 30) healthy adults and 12 age and gender matched normal weight (BMI \< 25) controls. All the participants will conduct a "wingate" anaerobic test (30 seconds of intense effort against resistance calculated by the individual's body weight). Blood sample for GH level will be collected at 5 different time (0, 20, 30, 40 and 60 minutes after the test). We will compare the GH response in the two groups.

Eligibility criteria: Inclusion Criteria:

* Healthy female
* Age 18-40

Exclusion Criteria:

* Male
* Age \<18, \>40
* Heart, Liver, Kidney or Hypophyseal disease
* Medications that may alter GH secretion (eg Steroids, Eltroxin)

Primary outcomes:
Secondary outcomes:
Other outcomes:
Locations:
city: Kfar Saba
country: Israel
facility: Meir Medical Center
Study officials:
affiliation: Meir Medical Center
name: Allon Eliakim, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT01821989: Oral Lactoferrin Supplementation for Prevention of Sepsis in Preterm Neonate
Official title: Oral Lactoferrin Supplementation for Prevention of Sepsis in Preterm Neonate.
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: EARLY_PHASE1
Conditions: Neonatal Sepsis
Lead sponsor: Mooselmokadem
Sponsor class: OTHER
First posted: 2013-04-01
Enrollment: 180
Sex: ALL
Maximum age (years): 28
Standard ages: CHILD
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: PREVENTION

Brief summary: Hypothesis:

Orally ingested lactoferrin has effects on promotion of growth and differentiation of the immature gut; also it has immunomodulatory properties, so it will prevent serious infections in preterm infants.

The aim of the study is to:

* Evaluate the effectiveness of oral lactoferrin in prevention of neonatal sepsis.
* Compare two dose regiment of lactoferrin supplementation.
* Study effect of lactoferrin supplementation on serum iron stores.

It is a prospective, randomized, double blind, placebo-controlled study, it will include 180 preterm neonates admitted to the Neonatal Intensive Care Units of of Ain Shams University Hospitals and Manshiet El Bakry Hospital.

•Group A: Who will receive oral lactoferrin supplementation in a dose of 100 mg/day.

•Group B: Who will receive oral lactoferrin supplementation in a dose of 150 mg/kg/ twice daily.

•Group C (Controls): Who match the subjected neonates, will receive placebo in form of distilled water.


Eligibility criteria: Inclusion Criteria:

1. Neonates with a birth weight between 500g and 2500g.
2. Neonates with a ≤ 36 weeks of gestation counting from the first day of the Last Menstrual Period.
3. Preterm neonates born in, or referred to the Neonatal Intensive Care Units of one of the participating hospitals in the first 48 hours of life.

Exclusion Criteria:

1. Neonates with underlying gastrointestinal problems that prevent oral intake.
2. Neonates with predisposing conditions that profoundly affect growth and development (chromosomal abnormalities, structural brain anomalies, severe congenital abnormalities).
3. Neonates with a family background of cow milk allergy.
4. Neonates who will not have the chance to complete the study time (who will be referred to another hospitals).
5. Neonates whose parents decline to participate.
6. Neonates with early onset sepsis.

Primary outcomes:
measure: Blood culture
timeFrame: 2 years
Secondary outcomes:
measure: Complete blood count with differential leucocytic count.
timeFrame: 2 years
Other outcomes:
measure: C reactive protein quantitative assay
timeFrame: 2 years
Locations:
city: Cairo
country: Egypt
facility: Ain Shams University
state: Abassia
Study officials:
References:
Clinical trial NCT04689789: OCTA and Retinal Angiomatous Proliferation
Official title: The Role of Quantitative Deep Capillary Plexus in the Pathogenesis of Retinal Angiomatous Proliferation: an Optical Coherence Tomography Angiography Study.
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Age Related Macular Degeneration
Lead sponsor: Federico II University
Sponsor class: OTHER
First posted: 2020-12-30
Enrollment: 118
Sex: ALL
Minimum age (years): 65
Maximum age (years): 80
Standard ages: OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: CASE_CONTROL
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: The participans were older than 65 years with diagnosis of age-related macular degeneration and in particular retinal angiomatous proliferation and reticular pseudodrusen.

They did not present other ophthalmological diseases.

Brief summary: To investigate, using optical coherence tomography angiography, the retinal vascular features in patients affected by RAP.

Detailed description: Retinal vascular anomalous complex represents a distinct form of neovascularization in patients with age-related macular degeneration.

The study investigated the changes in retinal vascular network using optical coherence tomography angiography, a novel and non invasive diagnostic technique that allows to better understand the pathophysiologic mechanism of this neovascularization.

Eligibility criteria: Inclusion Criteria:

* age older than 65 years
* diagnosis of retinal angiomatous proliferation and reticular pseudodrusen
* absence of previous ocular surgery, congenital eye disease, high myopia (\>6 dioptres), actual or previous diagnosis of glaucoma, optic disc anomaly, macular or vitreoretinal diseases.
* absence of significant lens opacities, low-quality OCT-A images.

Exclusion Criteria:

* age older than 80 years
* absence of diagnosis of retinal angiomatous proliferation and reticular pseudodrusen
* presence of previous ocular surgery, congenital eye disease, high myopia (\>6 dioptres), actual or previous diagnosis of glaucoma, optic disc anomaly, macular or vitreoretinal diseases.
* presence of significant lens opacities, low-quality OCT-A images.

Primary outcomes:
measure: The measurements of retinal vascular network in patients with age-related macular degeneration, using optical coherence tomography angiography, compared to controls
timeFrame: 15 months
Secondary outcomes:
Other outcomes:
Locations:
city: Naples
country: Italy
facility: Federico II University
state: Napoli
Study officials:
affiliation: Federico II University
name: Gilda Cennamo
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT05303389: Posterior Plating Versus Anterior to Posterior Screws in Fixation of Posterior Column in Pilon Fractures
Official title: Posterior Plating Versus Anterior to Posterior Screws in Fixation of Posterior Column in Pilon Fractures
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Tibial Fractures
Lead sponsor: Ain Shams University
Sponsor class: OTHER
First posted: 2022-03-31
Enrollment: 30
Sex: ALL
Minimum age (years): 16
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: Management of comminuted distal tibia fracture (pilon fracture) is still a challenging field. It is recently done guided by the new four column theory of distal tibia. Several approaches were advocated to address and fix each column. Fixation of posterior column is still a wide debate among orthopedic surgeons. This study is conducted to compare outcomes between two modalities for the management of posterior column fracture in pilon fractures.

Detailed description: The aim of this work is to assess and compare results of anterior to posterior screws versus posterior buttress plate in management of posterior column fracture in pilon fracture as regards functional, radiological outcomes and possible complications.

Optimal treatment of comminuted pilon fractures requires precise anatomical reduction. Several methods have been advocated to manage complex pilon fractures, but an optimal fixation technique remains controversial. On the basis of the anatomical characteristics of the ankle joint a four-column classification to guide the treatment of comminuted pilon fractures was proposed. The four-column classification can be summarized as follows: lateral column( the distal fibula), posterior column( the posterior part of the intermalleolus line with the distal tibial shaft), anterior column (the anterior part of the intermalleolus line with the distal tibial shaft) and medial column(the medial one-third of the tibial plafond with the distal tibial shaft).

A posterolateral incision is typically used to reduce and fix the posterior malleolar fragment to the tibial metaphysis which can be also done through the anterior incision using anterior to posterior screws.

Eligibility criteria: Inclusion Criteria:

* Two, Three and four column pilon fracture

Exclusion Criteria:

* Pathological fractures.
* Pediatric age group with open physis.

Primary outcomes:
measure: The American Orthopaedic Foot and Ankle Society (AOFAS) scoring system
timeFrame: up to one year
Secondary outcomes:
Other outcomes:
Locations:
city: Cairo
country: Egypt
facility: Ain Shams University
Study officials:
affiliation: Ain Shams University
name: Tamer Fayyad, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT00460889: Renal Donor Comparison of Outcomes: Hand Assist Versus Laparoscopic Nephrectomy
Official title: Renal Donor Comparison of Outcomes: Hand Assist Versus Laparoscopic Nephrectomy
Study type: OBSERVATIONAL
Overall status: WITHDRAWN
Conditions: Living Renal Donor
Keywords: hand assist
laparoscopy
renal donor
outcomes
Lead sponsor: Columbia University
Sponsor class: OTHER
First posted: 2007-04-17
Enrollment: 0
Sex: ALL
Minimum age (years): 18
Maximum age (years): 80
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Time perspective: RETROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Surgical clinic

Brief summary: This study is designed to look at outcomes of patients who have undergone hand assisted laparoscopic donor nephrectomy versus totally laparoscopic donor nephrectomy.


Eligibility criteria: Inclusion Criteria:

* any person undergoing minimally invasive donor nephrectomy surgery at NewYork Hospital/Columbia.

Exclusion Criteria:

* any person undergoing open donor nephrectomy surgery at NewYork Hospital/Columbia.

Primary outcomes:
measure: Prevalence of postoperative comfort and hospital stay satisfaction with HALDN
timeFrame: 1 week
measure: Prevalence of postoperative comfort and hospital stay satisfaction with LDN
timeFrame: 1 week
Secondary outcomes:
Other outcomes:
Locations:
city: New York
country: United States
facility: Columbia University College of Physicians and Surgeons
state: New York
Study officials:
affiliation: Columbia University
name: Dennis L Fowler, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT06730789: Conservative Treatment in Lateral Epicondylitis
Official title: Prospective Comparison of Conservative Treatment Methods in Patients With Lateral Epicondylitis
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Lateral Epicondylitis
Lead sponsor: Uludag University
Sponsor class: OTHER
First posted: 2024-12-12
Enrollment: 54
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: Conservative treatments follow the vast majority of treatments in lateral epicondylitis. In this research, we aimed to elucidate the treatment outcomes of patients via epicondylitis bandage, wrist dorsiflexion splint, and kinesio tape groups by sequential randomization and to compare treatment outcomes.


Eligibility criteria: Inclusion Criteria:

* Patients who were ≥18 years of age, and had no history of elbow surgery.
* Participants should have pain and sensitivity, with symptom duration less than 12 weeks.
* Patients with a positive result in one of the provocation tests (Maudsley's Test-resisted middle finger extension extensor carpi radialis test), resisted wrist extension, or passive stretching of the wrist extensors (Mill's Test) were included.

Exclusion Criteria:

* Patients under 18 years of age,
* patients who did not consent to participate in the study,
* those who had previous surgery on the elbow,
* presence of cervical spondylosis and radiculopathy,
* presence of endocrine disease,
* presence of autoimmune disease,
* presence of concomitant entrapment neuropathy or polyneuropathy,
* pregnancy,
* presence of systemic inflammatory disease,
* presence of acute trauma,
* presence of deformity in the upper extremity,
* presence of metabolic disease,
* presence of elbow arthritis,
* presence of allergy to kinesio tape and orthoses,
* having received treatment for lateral epicondylitis in the past (exercise, injection, NSAIDs).

Primary outcomes:
measure: Visual analog score
timeFrame: Baseline
measure: Visual analog score
timeFrame: At sixth weeks.
Secondary outcomes:
measure: Disabilities of the Arm, Shoulder Score
timeFrame: Baseline
measure: Disabilities of the Arm, Shoulder Score
timeFrame: At sixth weeks.
Other outcomes:
measure: Patient-Rated Tennis Elbow Evaluation Score
timeFrame: Baseline
measure: Patient-Rated Tennis Elbow Evaluation Score
timeFrame: At sixth weeks.
measure: hand grip strength
timeFrame: Baseline
measure: hand grip strength
timeFrame: At sixth weeks.
Locations:
city: Bursa
country: Turkey
facility: Bursa Uludag University
state: Nilüfer
Study officials:
References:
Clinical trial NCT02907489: Effect of Triple Antibiotic Paste as an Intracanal Medication With an Anti-Inflammatory Drug on Post-operative Pain.
Official title: The Effect of Triple Antibiotic Paste as an Intracanal Medication With an Anti-Inflammatory Drug on Post-Operative Pain of Asymptomatic Uniradicular Necrotic Teeth (A Double Blind Randomized Clinical Trial).
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE1
Conditions: Asymptomatic Necrotic Teeth
Keywords: post operative pain
triple antibiotic paste
intracanal medication
Lead sponsor: Cairo University
Sponsor class: OTHER
First posted: 2016-09-20
Enrollment: 84
Sex: ALL
Minimum age (years): 18
Maximum age (years): 50
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The purpose of this study is to determine whether the use of triple antibiotic paste as intracanal medication with an anti-inflammatory drug, compared to a calcium hydroxide will reduce postoperative pain and intracanal bacteria or not in patients with asymptomatic necrotic teeth.

Detailed description: This trial is aiming to answer a clinical question whether in patients with asymptomatic necrotic teeth, the use of triple antibiotic paste as intracanal medication with an anti-inflammatory drug, compared to a calcium hydroxide, reduce postoperative pain and intracanal bacteria or not? trial design will be Randomized, controlled, double blinded, unicenter, parallel, two-arm, superiority trial with 1:1 allocation ratio.

Eligibility criteria: Inclusion Criteria:

1. Subject's age between 18-50 years.
2. Both male and female subjects.
3. Medically free and healthy subjects.
4. Mandibular and maxillary single rooted teeth.
5. Asymptomatic non vital teeth.

Exclusion Criteria:

1. Teeth with acute dentoalveolar abscess.
2. Subjects having more than one tooth that require root canal treatment.
3. Subjects that have taken analgesic, anti-inflammatory or antibiotic drugs during the 10 days prior to the start of treatment.
4. Pregnant females.
5. Subjects with systemic diseases who have endocrine diseases, Infectious diseases or Psychological disturbance.
6. Teeth with periodontal disease or pulp calcification.
7. Subjects taking chronic pain medications.

Primary outcomes:
measure: Post Operative Pain
timeFrame: after 24, 48, and 72 hour from the end of the first visit.
Secondary outcomes:
measure: Intracanal Bacterial Count
timeFrame: before and after mechanical preparation (at day 0) and after 72 hour from placement of the intracanal medication.
Other outcomes:
Locations:
Study officials:
References:
Clinical trial NCT03114189: Kneipp Water Applications for Insomnia
Official title: Effects of Ascending Warm Footbaths on Sleep Disturbances in Women Before Climacteric
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Sleep Disturbance
Keywords: Sleep disturbance
footbath
Kneipp
care of sleep
sleep
Lead sponsor: Universität Duisburg-Essen
Sponsor class: OTHER
First posted: 2017-04-14
Enrollment: 52
Sex: FEMALE
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The purpose of this study is to ascertain whether warm footbathes are effective on sleep disturbances in women before climacteric.


Eligibility criteria: Inclusion Criteria:

* Minimum age: 18 years
* Regularly recurring sleeping disease (not less then 2 times a week for minimum 3 month)

Exclusion Criteria:

* secundary sleeping disease
* Mental diseases which require therapy
* Medication: benzodiazepine,Z-drugs, barbiturat, antihistaminika, melatonin
* Severe comorbidity
* Gravidity
* Shift work
* Voyages (\>3 times during the study)
* regulary application of Kneipp
* Participation on other studies to therapy sleeping diseases or stress

Primary outcomes:
measure: Change of sleep quality
timeFrame: T1: At the beginning of intervention, T2: After 4 weeks of intervention, T3: 12 weeks after randomization
Secondary outcomes:
Other outcomes:
Locations:
city: Essen
country: Germany
facility: • Department of Internal and Integrative Medicine, Kliniken Essen-Mitte, Faculty of Medicine, University of Duisburg-Essen
Study officials:
References: