louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT06828978: Clinical and Radiographic Success Following Regenerative Pulpotomy Using Chitosan Hydrogel Versus Platelet Rich Fibrin in Mature Mandibular Molars
Official title: Clinical and Radiographic Success Following Regenerative Pulpotomy Using Chitosan Hydrogel Versus Platelet Rich Fibrin in Mature Mandibular Molars: A Randomized Clinical Trial
Study type: INTERVENTIONAL
Overall status: NOT_YET_RECRUITING
Phase: NA
Conditions: Regenerative Pulpotomy for Symptomatic Pulpitis of Mandibular Permanent Molars With Mature Apices
Lead sponsor: Cairo University
Sponsor class: OTHER
First posted: 2025-02-17
Enrollment: 36
Sex: ALL
Minimum age (years): 18
Maximum age (years): 40
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The aim of this study is to assess the clinical and radiographic success and postoperative pain in mature mandibular molars following vital pulp therapy using chitosan hydrogel versus platelet rich fibrin.


Eligibility criteria: Inclusion Criteria:

* Patients suffering from Symptomatic pulpitis in mature mandibular molars only will be involved.
* Tooth should give positive response to cold test
* Haemostasis should be achieved after full pulpotomy
* The tooth is restorable and free from advanced periodontal disease, cracks and splits.
* Patients should be free from any systemic disease that may affect normal healing and predictable outcome.
* Patients who will agree to the consent and will commit to follow-up period.
* Patients with mature root apices
* Patients with no internal or external resorption and no periapical lesions
* Soft tissues around the tooth are normal with no swelling or sinus tract

Exclusion Criteria:

* Patients with immature roots.
* Haemostasias after 10 minutes cannot be controlled after full pulpotomy Patients with any systemic disease that may affect normal healing.
* Patients with periapical lesions or infections.
* Pregnant females.
* Patients who could/would not participate in a 6 months follow-up.
* Patients with fistula or swelling
* Patients with necrotic pulp.
* Patients with old age.

Primary outcomes:
measure: Success Rate
timeFrame: 6 months (Postoperative)
Secondary outcomes:
measure: Postoperative pain
timeFrame: 1st day up to 7th day
measure: Tooth sensibility
timeFrame: 1,3,6 months (postoperative)
Other outcomes:
Locations:
Study officials:
References:
Clinical trial NCT05825378: The Effect of Intercostal Nerve Block With Dexamethasone and Ropivacaine on Rebound Pain After Thoracoscopic Surgery
Official title: The Effect of Intercostal Nerve Block With Dexamethasone and Ropivacaine on Rebound Pain After Thoracoscopic Surgery: a Randomized, Double-blind, Controlled Study
Study type: INTERVENTIONAL
Overall status: NOT_YET_RECRUITING
Phase: NA
Conditions: Rebound Pain
Dexamethasone
Intercostal Nerve Block
Thoracoscopic Surgery
Lead sponsor: Beijing Tiantan Hospital
Sponsor class: OTHER
First posted: 2023-04-24
Enrollment: 260
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: Regional nerve block is one of the commonly used methods for postoperative analgesia after thoracoscopic surgery. Recent studies have found that rebound pain may occur after regional block, which is defined as acute postoperative pain that occurs after the resolution of sensory block related to regional anesthesia, and seriously affects the quality of postoperative recovery of patients. There is evidence that rebound tenderness is associated with local anesthetic toxicity and proinflammatory effects. The aim of this study was to investigate the effect of dexamethasone on rebound pain after a single intercostal nerve block in patients undergoing thoracoscopic surgery.


Eligibility criteria: Inclusion Criteria:

* Patients scheduled for elective thoracoscopic surgery Age \> 18 years old ASA ⅰ-ⅲ Informed consent was signed

Exclusion Criteria:

* Patients with aoagulation disorders Patients with allergy to local anesthetics Patients with severe cardiopulmonary diseases Patients had systemic steroid use Patients with chronic pain Patients with uncontrolled diabetes and mental disorders History of drug abuse; Body Mass Index more than 35 kg.m-2 Pregnant or breastfeeding woman.

Primary outcomes:
measure: The incidence of rebound pain after the disappearance of nerve block effect
timeFrame: 8 hours after the nerve block
Secondary outcomes:
Other outcomes:
Locations:
city: Beijing
country: China
facility: Beijing Tiantan Hospital, Capital Medical University
Study officials:
References:
Clinical trial NCT05796778: Sub Omohyoid Suprascapular Nerve Block Versus Interscalene Nerve Block
Official title: Sub Omohyoid Suprascapular Nerve Block Versus Interscalene Nerve Block for Postoperative Shoulder Surgery Pain: Randomized Comparative Study.
Study type: INTERVENTIONAL
Overall status: RECRUITING
Phase: NA
Conditions: Post Operative Pain
Regional Anesthesia
Nerve Block
Keywords: Interscalene brachial plexus block
shoulder pain
subomohyoid plane block
Lead sponsor: Minia University
Sponsor class: OTHER
First posted: 2023-04-04
Enrollment: 72
Sex: ALL
Minimum age (years): 18
Maximum age (years): 60
Standard ages: ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: PREVENTION

Brief summary: Shoulder surgery can be very painful surgery after which the use of opioids is often required. The well-known side-effects of opioids (e.g. respiratory depression, somnolence, nausea, vomiting, and pruritus) limit their use in so called 'fast track' surgery and anaesthesia programmes.

the study aimed to compare the effect of sub omohyoid suprascapular nerve block versus interscalene nerve block in preventing postoperative pain and decreasing analgesic consumption in patients scheduled for shoulder surgery


Eligibility criteria: Inclusion Criteria:

1. Aged 18-60 years.
2. ASA I-II.
3. Both sexes.
4. Shoulder surgery.

Exclusion Criteria:

1. Patient refusal
2. Allergy to local anesthetics
3. BMI \>40 kg/m2
4. Bleeding diathesis or history of anticoagulant use.
5. Psychiatric diseases.
6. Infection of the skin at the site of needle punctures area.

Primary outcomes:
measure: Visual analogue pain score
timeFrame: 24 hour
Secondary outcomes:
measure: Time of first analgesic request
timeFrame: 24 hour
measure: Total analgesic consumption
timeFrame: 24 hour
measure: Incidence of any side effects
timeFrame: 24 hour
Other outcomes:
Locations:
city: Minya
country: Egypt
facility: Minia University Hospital
Study officials:
affiliation: Minia University, faculty of medicine
name: hassan m. hetta, lecturer
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT03010878: Yoga and Occupational Therapy to Improve Pain
Official title: Yoga and Occupational Therapy to Improve Pain
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Chronic Pain
Keywords: yoga
chronic pain
occupational therapy
self-management
Lead sponsor: Colorado State University
Sponsor class: OTHER
First posted: 2017-01-05
Enrollment: 83
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: This was a randomized control trial of a yoga and self-management intervention for individuals with chronic pain. Participants were assigned to either a wait-list control group (self-management only), or a yoga intervention (self-management and yoga). Self-management education session occurred monthly within the community. Group yoga intervention was delivered two times a week with a specifically designed program that was progressively more difficult. Assessments were then administered pre and post intervention, and a semi-structured interview was completed following the intervention. Quantitative and qualitative data were then compared between groups.

Detailed description: This was a randomized control trial completed with two specific aims.

Aim 1: To assess the feasibility of completing a group yoga intervention in conjunction with an ongoing self-management education for people with chronic pain.

Aim 2: To explore the preliminary efficacy of a group yoga intervention in people with chronic pain. The key variables of interest were pain interference, functional performance, balance, strength, mobility, and quality of life (QoL)

Eligibility criteria: Inclusion Criteria:

* greater than 18 years of age
* Individual with self-reported pain for over six months
* attending outpatient pain clinic
* ability to attend yoga classes
* ability to complete assessments
* ability to provide informed consent

Exclusion Criteria:

* consistent yoga practice over the past year
* self-reported exercise restrictions
* serious and recent medical procedures or conditions without doctor's note
* high risk pregnancy

Primary outcomes:
measure: Brief Pain Inventory--Short Form
timeFrame: 8 weeks
Secondary outcomes:
Other outcomes:
Locations:
city: Fort Collins
country: United States
facility: UC Health Fort Collins Family Medicine Residency Program Pain Management Clinic
state: Colorado
Study officials:
affiliation: Colorado State University
name: Arlene Schmid, PhD
role: PRINCIPAL_INVESTIGATOR
References:
citation: Schmid AA, Atler KE, Malcolm MP, Grimm LA, Klinedinst TC, Marchant DR, Marchant TP, Portz JD. Yoga improves quality of life and fall risk-factors in a sample of people with chronic pain and Type 2 Diabetes. Complement Ther Clin Pract. 2018 May;31:369-373. doi: 10.1016/j.ctcp.2018.01.003. Epub 2018 Feb 15.
Clinical trial NCT01901978: Study to Investigate Benefits of Weight Loss in Young Adults and Adolescents
Official title: Study to Investigate Benefits of Weight Loss in Yound Adults and Adolescents
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Obesity
Insulin Resistance
Keywords: Obesity
Insulin Resistance
Weight loss
Women
Lead sponsor: Yale University
Sponsor class: OTHER
Collaborators: name: National Institutes of Health (NIH)
name: Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
First posted: 2013-07-17
Enrollment: 14
Sex: FEMALE
Minimum age (years): 16
Maximum age (years): 32
Standard ages: CHILD
ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: HEALTH_SERVICES_RESEARCH

Brief summary: The purpose of this study is to investigate the changes in subcutaneous adipocyte size, number and gene expression after weight loss and to assess whether those changes contribute to decreases in ectopic fat accumulation and insulin resistance in women between ages of 16-32.

Detailed description: There are no studies in young women that have prospectively studied changes in fat cell size, gene expression and insulin sensitivity during the transition from overweight/obese to normal weight. Our preliminary data suggest that the presence of ectopic fat accumulation and insulin resistance in obese children could be considered an "early phase" in the development of T2DM. We hypothesize that a 10% weight loss will restore/improve insulin sensitivity. Furthermore, we speculate that the decrease in subcutaneous fat mass after weight loss is due to a decrease in mean adipocyte cell size, but not cell number.

Eligibility criteria: Inclusion Criteria:

* Women ages 16-32

Exclusion Criteria:

* They will not be on any medications that are known to alter glucose or insulin metabolism, such as oral steroids, or certain psychiatric medications, such as Xeleca, Lithium and Paxil. Patients on diuretics will be excluded.

Primary outcomes:
measure: Abdominal fat re-distribution with weight loss
timeFrame: 12 weeks
Secondary outcomes:
measure: Adipocyte cell size distrubtion and gene expression
timeFrame: 12 week
Other outcomes:
Locations:
city: New Haven
country: United States
facility: Yale University
state: Connecticut
Study officials:
affiliation: Yale University
name: Sonia Caprio, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT05125978: Efficacy and Safety of Canadá Association in the Treatment of Chronic Pain
Official title: National, Multicenter, Randomized, Double-blind, Triple-dummy, Phase II Clinical Trial to Evaluate the Efficacy and Safety of Canadá Association in the Treatment of Chronic Pain
Study type: INTERVENTIONAL
Overall status: WITHDRAWN
Phase: PHASE2
Conditions: Pain, Chronic
Keywords: Analgesia
Pain Management
Lead sponsor: EMS
Sponsor class: INDUSTRY
First posted: 2021-11-18
Enrollment: 0
Sex: ALL
Minimum age (years): 15
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The purpose of this study is to evaluate the efficacy and safety of Canadá association in the treatment of chronic pain


Eligibility criteria: Inclusion Criteria:

* Ability to confirm voluntary participation and agree to all trial purposes by signing and dating the consent form;
* Chronic pain during at least 3 months.

Exclusion Criteria:

* Any clinical and laboratory findings that, in the judgment of the investigator, may interfere with the safety of participants;
* History of alcohol abuse or illicit drug use;
* Participation in a clinical trial in the year prior to this study;
* Pregnancy or risk of pregnacy and lactating participants;
* Known hypersensitivity to any of the formula compounds.

Primary outcomes:
measure: Difference in pain intensity assessed by the VAS scale
timeFrame: 12 weeks
Secondary outcomes:
measure: Adverse events
timeFrame: 16 weeks
Other outcomes:
Locations:
Study officials:
References:
Clinical trial NCT02826278: Genitalia and Androgen in New Born Girls
Official title: Study Protocol: Reference Values for External Genitalia and Androgen Blood Level in New Born Girls
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Newborn Genitalia
Keywords: Newborn genitalia
reference charts
Lead sponsor: Hospices Civils de Lyon
Sponsor class: OTHER
First posted: 2016-07-07
Enrollment: 180
Sex: FEMALE
Maximum age (years): 3
Standard ages: CHILD
Accepts healthy volunteers: yes
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Female newborns, with gestational ages of 24 to 41 weeks of pregnancy.

Brief summary: Normal values for female external genitalia size at birth, particularly clitoris and blood level of androgens are not well known. This study's aim is to collect normal values in 180 newborn girls of 24 to 41 weeks of pregnancy, and to build genitalia growth charts according to gestational age and birth weight.

The investigators will measure clitoris, genito-anal ratio using a small plastic caliper, at birth, and their evolution until Day 3 of life (if the child is still at the hospital).

The investigators also want to establish normal values of blood testosterone, 17-hydroxyprogesterone, delta4-androstenedione, 21-deoxycortisol, 11-deoxycortisol, deoxycorticosterone, corticosterone, dehydroepiandrostenedione, and dihydrotestosterone), using samples taken for systematic post natal screening of diseases (only in new born of 35 or more weeks of birth).

This is an observational prospective study.


Eligibility criteria: Inclusion Criteria:

* Healthy female newborns 24 to 41 weeks of pregnancy without sexual development disturbances. Dysmature children - i.e. those with a - 2DS birth weight or height at are not excluded.

Exclusion Criteria:

* Sexual development abnormality, diagnosed pre- or post- birth, endocrine disorder, obstetric trauma affecting genitalia, malformation syndrome, midline abnormalities, congenital cancer, maternal ovary or adrenal tumor diagnosed during pregnancy, mother or father's treatment during pregnancy likely to virilize the fetus, family history of congenital adrenal hyperplasia or neurofibromatosis

Primary outcomes:
measure: length of the clitoris
timeFrame: Day 1
measure: length of the clitoris
timeFrame: Day 3
Secondary outcomes:
measure: clitoris width
timeFrame: Day 1
measure: clitoris width
timeFrame: Day 3
measure: anogenital ratio
timeFrame: Day 1
measure: anogenital ratio
timeFrame: Day 3
measure: Blood level of testosterone
timeFrame: Day 3
measure: Blood level of 17-hydroxyprogesterone
timeFrame: Day 3
measure: Blood level of delta4-androstenedione
timeFrame: Day 3
measure: Blood level of 21-deoxycortisol
timeFrame: Day 3
measure: Blood level of corticosterone
timeFrame: Day 3
measure: Blood level of dihydrotestosterone
timeFrame: Day 3
Other outcomes:
Locations:
city: Bron
country: France
facility: Hopital Femme Mere Enfant
Study officials:
affiliation: Hospices Civils de Lyon
name: Claire-Lise GAY, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT06268678: The Effect of Menstrual Cycle Phase on Muscle Protein Synthesis
Official title: The Effect of Menstrual Cycle Phase on Muscle Protein Synthesis Following Protein Ingestion and Resistance Exercise in Young Women
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Menstrual Cycle Phase
Muscle Protein Synthesis
Lead sponsor: University of Exeter
Sponsor class: OTHER
Collaborators: name: Pvolve
First posted: 2024-02-20
Enrollment: 14
Sex: FEMALE
Minimum age (years): 18
Maximum age (years): 40
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: CROSSOVER
Intervention model description: Randomised cross-over design.
Primary purpose: BASIC_SCIENCE

Brief summary: The combination of dietary protein ingestion and resistance exercise are essential to increase muscle protein synthesis. The vast majority of studies assessing protein intake following resistance exercise in young adults has been conducted exclusively in men or in studies where both men and women are assessed. The increase in muscle mass is thought to be impacted by sex hormones that fluctuate across different phases of the menstrual cycle. However, the effect of menstrual cycle phase on muscle protein synthesis following exercise is not known.


Eligibility criteria: Inclusion Criteria:

* Female, aged 18-40 years
* BMI between 18 and 30 kg/m2
* Recreationally active
* Regular menstrual cycle

Exclusion Criteria:

* Smoking or use of tobacco containing products
* Irregular menstrual cycle
* Currently on any form of hormonal contraception
* Post-menopausal
* Pregnant or breastfeeding
* Diagnosed metabolic/pulmonary/musculoskeletal illness
* Diagnosed cardiovascular disease or hypertension
* Use of medications that may impact protein metabolism or are anti-inflammatory
* Gastrointestinal disorders
* Allergy to pomegranate or amino acids
* Injuries that would impact ability to complete study

Primary outcomes:
measure: Muscle protein synthesis
timeFrame: 7 hours
Secondary outcomes:
measure: Plasma amino acid kinetics
timeFrame: 7 hours
measure: Serum insulin concentrations
timeFrame: 7 hours
measure: Sex hormone concentrations
timeFrame: 5 minutes
measure: Energy expenditure
timeFrame: 20 minutes
Other outcomes:
Locations:
city: Exeter
country: United Kingdom
facility: University of Exeter
state: Devon
Study officials:
affiliation: University of Exeter
name: Francis Stephens
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT06002178: Ultrasound Evaluation of the Vascular Anatomy of the Neck to Minimize the Accidental Risk of Vascular Puncture During Percutaneous Tracheostomy
Official title: Ultrasound Evaluation of the Vascular Anatomy of the Neck to Minimize the Accidental Risk of Vascular Puncture During Percutaneous Tracheostomy
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Tracheostomy Complication
Trachea
Lead sponsor: University of Padova
Sponsor class: OTHER
First posted: 2023-08-21
Enrollment: 500
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: All adult patients accessing the operating room for any reason

Brief summary: Tracheostomy is a commonly performed procedure in Intensive Care and its incidence tends to increase over time as a consequence of the increase in chronic diseases and the average age of the population accessing Intensive Care.

Surgical open tracheostomy (ST) is the standard procedure but has a relatively high incidence of peristomal infections and perioperative bleeding. Percutaneous dilatational tracheostomy (PDT) was introduced in 1985 and has since become a common bedside procedure. Compared to open ST, PDT has the advantages of a lower risk of wound infection, lower bleeding-related mortality, shorter procedure times, and improved cost-effectiveness.

Fiberoptic bronchoscopy is commonly used during PDT to verify the safety of direct tracheal access \[5\]. However, bronchoscopy-guided PDT has several limitations regarding the precise identification of cervical anatomical structures and the prevention of complications such as vascular injury.

Preliminary ultrasound examination of neck anatomy has numerous potential benefits, including increased safety during the procedure, identification of cervical vascularization, and localization of the tracheal puncture site with lower risk of complications \[6-8\]. Several studies have shown that the use of ultrasound in a preliminary and real-time manner can improve first-pass success rate and puncture accuracy, reduce procedure time, and complications.

The objective of this study is to map the arterial and venous vascular anatomy of the neck in order to identify points with a lower risk of vascular injury during PDT. This helps prevent bleeding during tracheostomy, which is one of the major complications associated with the procedure.


Eligibility criteria: Inclusion Criteria:

* Patients of eighteen years or older
* Informed consent

Exclusion Criteria:

* Tracheostomized patients

Primary outcomes:
measure: Mapping of artery and veins of the neck in the general population
timeFrame: through study completion, an average of 1 year
measure: Size of artery and veins of the neck in the general population
timeFrame: through study completion, an average of 1 year
Secondary outcomes:
Other outcomes:
Locations:
city: Padova
country: Italy
facility: University Hospital of Padova
state: Veneto
Study officials:
References: