Clinical trial NCT01134978: Neural Mechanisms of the Contextual Interference Effect: A fNIRs and EEG Study
Official title: Neural Mechanisms of the Contextual Interference Effect: A fNIRs and EEG Study
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE1
Conditions: Healthy Individuals
Learning
Keywords: repeated measures design
random assignment to groups
Lead sponsor: Drexel University
Sponsor class: OTHER
Collaborators: name: Pennsylvania Department of Health
First posted: 2010-06-02
Enrollment: 20
Sex: ALL
Minimum age (years): 18
Maximum age (years): 55
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: BASIC_SCIENCE

Brief summary: The overall goal of this study is to gain insight into the neural mechanisms of learning multiple tasks. By examination of cognitive and behavioral output during the performance and learning of several computer maze tasks, and through a detailed examination of the neural activity obtained from functional near-infrared (fNIR) and electroencephalography (EEG), it may be possible to gain insight into the impact of the amount of practice and the organization of practice has on learning fine motor skills. This insight may provide direction as to how to better develop instructional and rehabilitation protocols in addition to clinical interventions to facilitate recovery of function, relearning and transfer of cognitive and fine motor skills based upon neural responses to physical practice.


Eligibility criteria: Inclusion Criteria:

* 18 to 55 years of age
* vision correctable to 20/20
* right-handed
* English is first language or learned English before age of 5 years

Exclusion Criteria:

* 17 years or younger and 56 years or older
* pregnant
* have latex or tape adhesives allergies
* self-exclude if:
* had a history of seizures, head injury or neurological dysfunction
* history or diagnosis of depression, schizophrenia or social phobia
* previous admission to alcohol/drug treatment program or diagnosis of alcohol/drug abuse
* take medications know to affect neurological function.

Primary outcomes:
measure: metabolic measures of neural activity in the dorsolateral prefrontal cortex
timeFrame: outcomes measured 72 - 96 hours post-training
Secondary outcomes:
measure: Behavioral measures
timeFrame: measured 72-96 hours post training
Other outcomes:
Locations:
city: Philadelphia
country: United States
facility: Cognitive Motor Movement Neuroscience Lab (CoMMoNS) - rm 3612 NCB, Drexel University
state: Pennsylvania
Study officials:
affiliation: Drexel University
name: Patricia A Shewokis, PhD
role: PRINCIPAL_INVESTIGATOR
References:
citation: Ayaz H, Shewokis PA, Curtin A, Izzetoglu M, Izzetoglu K, Onaral B. Using MazeSuite and functional near infrared spectroscopy to study learning in spatial navigation. J Vis Exp. 2011 Oct 8;(56):3443. doi: 10.3791/3443.
citation: Shewokis PA, Ayaz H, Izzetoglu M, Bunce S, Gentili RJ, Sela I, Izzetoglu K, Onaral B. Brain in the Loop: Assessing Learning using fNIR in cognitive and motor tasks. D.D. Schmorrow and C.M. Fidopiastis (Eds.).Lecture Notes in Artificial Intelligence, 6780: 240-249. 2011. Springer-Verlag Berlin Heidelberg 2011.
citation: Shewokis PA, Ayaz H, Izzetoglu K, Izzetoglu M, Bunce SC, Schultheis MT, Pourrezaei K. Dorsolateral prefrontal cortex activity during the learning of computer tasks in a contextual interference paradigm using fNIRs: a case series. Journal of Sport & Exercise Psychology 30: S130. 2008.
citation: Shewokis PA, Ayaz H, Izzetoglu M, Getchell N, Izzetoglu K. the acquisition and learning of computer tasks in a contextual interference paradigm: Using functional near infrared spectroscopy to examine prefrontal cortex activity. Journal of Sport & Exercise Psychology. 32: S127-S128. 2010.