louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT06611488: Sleep Disturbances on Postural Control in the Elderly Population
Official title: Effect of Sleep Disturbances on Postural Control in the Elderly Population
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Sleep Quality
Postural Stability
Keywords: Sleep disturbances
Postural control
Elderly population
Lead sponsor: Cairo University
Sponsor class: OTHER
Collaborators: name: Majmaah University
First posted: 2024-09-25
Enrollment: 30
Sex: ALL
Minimum age (years): 67
Standard ages: OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: OTHER
Time perspective: CROSS_SECTIONAL
Sampling method: PROBABILITY_SAMPLE
Study population: Elderly participant with age 67 years and more

Brief summary: The sleep disorders are common among older adults and comprises of wide spectrum of the sleep related issues like poor sleep quality, sleep deprivation and excessive day time sleepiness.

Detailed description: Earlier studies were carried to determine the effect of sleep deprivation on the postural control parameters. The effect of poor sleep quality and excessive daytime sleepiness on the postural control were not widely studied. Aim : To determine the effect of the sleep quality and excessive daytime sleepiness on the postural stability during quiet standing and whether this influence vary based on the availability of the visual feedback.

Eligibility criteria: Inclusion Criteria:

* Be able to stand unsupported with eyes opened and eyes closed for 30 seconds.

Exclusion Criteria:

* Elderly with uncorrected visual impairment, Underwent bilateral hip replacement.
* Participants using drugs which affect control.
* Participants with previous history of conditions which affect postural control.

Primary outcomes:
measure: Postural stability using STABLE platform
timeFrame: "Immediately after enrollment"
Secondary outcomes:
Other outcomes:
measure: Sleep parameters using the Arabic version of Pittsburgh Sleep Quality Index
timeFrame: "Immediately after enrollment"
measure: Day time sleepiness using The Arabic version of Epworth Sleepiness Scale.
timeFrame: "Immediately after enrollment"
Locations:
city: Al Majmaah
country: Saudi Arabia
facility: The Majmaah University
state: Riyadh/ Saudi Arabia
Study officials:
affiliation: The Majmaah University
name: Abdulrhman Y Alqahtani, Master degree
role: PRINCIPAL_INVESTIGATOR
affiliation: Cairo University
name: Zeinab A Ali, PhD
role: STUDY_DIRECTOR
affiliation: Cairo University
name: Shaimaa M Elsayeh, PhD
role: STUDY_DIRECTOR
References:
citation: Melzer I, Benjuya N, Kaplanski J. Age-related changes of postural control: effect of cognitive tasks. Gerontology. 2001 Jul-Aug;47(4):189-94. doi: 10.1159/000052797.
Clinical trial NCT01407588: Manual Compared to Magnetic Navigation in Ablation for Atrial Fibrillation
Official title: Manual Compared to Magnetic Navigation in Ablation for Atrial Fibrillation
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Atrial Fibrillation
Keywords: Atrial fibrillation
Ablation
Lead sponsor: Norwegian University of Science and Technology
Sponsor class: OTHER
Collaborators: name: St. Olavs Hospital
name: SINTEF Health Research
First posted: 2011-08-02
Enrollment: 51
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The purpose of this study is to compare manual and magnetic navigation in ablation for atrial fibrillation.


Eligibility criteria: Inclusion Criteria:

* Undergoing ablation for atrial fibrillation at St. Olavs Hospital
* Implanted Reveal

Primary outcomes:
measure: Number of participants with recurrence of atrial fibrillation after ablation
timeFrame: 2 years
Secondary outcomes:
measure: Procedure time
timeFrame: Day 1(after ablation procedure)
measure: Number of Participants with Adverse Events as a Measure of Safety and Tolerability
timeFrame: Day 1(after ablation procedure)
measure: Exposure of radiation to health personnel involved in the procedure
timeFrame: Day 1(after ablation procedure)
measure: Amount of analgetics and sedatives given during procedure
timeFrame: Day 1
measure: Pain
timeFrame: After ablation(day 1)
measure: Numbers of and types of catheters used
timeFrame: During ablation(Day1)
measure: Time with active ablation
timeFrame: During the procedure(Day 1)
measure: Total time nurses are occupied with the ablation
timeFrame: During the ablation(day 1)
measure: Myocardial damage
timeFrame: After ablation(day 1)
measure: Cardiac volumes and function
timeFrame: 1 year
measure: Quality of life
timeFrame: 2 years
Other outcomes:
Locations:
city: Trondheim
country: Norway
facility: Norwegian University of Science and Technology
Study officials:
affiliation: St. Olavs Hospital
name: Jan Paal Loennechen, PhD
role: STUDY_CHAIR
References:
Clinical trial NCT01057888: Evaluation of Vaccination Reminder/Recall Systems for Adolescent Patients
Official title: Randomized Controlled Trial of an Automated, Managed Care-based Reminder/Recall System on Improving Rates of Immunization and Preventive Care Visits for Publically Insured Adolescents
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Immunization Status
Well Child Care Visit
Keywords: Immunization status for:
Tdap
Menactra
HPV (if female)
Well child care visit
Lead sponsor: University of California, Los Angeles
Sponsor class: OTHER
Collaborators: name: Centers for Disease Control and Prevention
First posted: 2010-01-27
Enrollment: 10599
Sex: ALL
Minimum age (years): 11
Maximum age (years): 18
Standard ages: CHILD
ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: HEALTH_SERVICES_RESEARCH

Brief summary: The investigators will design and implement a randomized clinical trial to test, on a community-wide level, the effectiveness of managed care based tracking/reminder/recall on improving vaccination coverage among adolescents.

The investigators propose a randomized controlled trial to evaluate the effectiveness of reminder/recall for adolescents: 10,599 adolescents within the managed care organization (MCO) will be randomized into one of three arms: 1) mailed reminders, 2) autodialer telephone messages or 3) standard of care of their practice (no messages from the intervention).

Hypothesis 1: Reminder/recall will increase the receipt of immunizations and preventive services

Hypothesis 2: Telephone (autodialer) reminders will be more effective than mailed reminders

Hypothesis 3: The impact of reminders will be greatest for the most high-risk subgroups which have low baseline immunization rates.

Hypothesis 4: Mailed reminders will be more costly (and less effective) than telephone reminders.


Eligibility criteria: Inclusion Criteria:

* Member of the Monroe Plan for Medical Care (managed care organization)
* Patient of a participating practice
* Ages 10.75 to \<18 years of age

Exclusion Criteria:

* Member of the Monroe Plan for Medical care for less than 6 months
* ICD-9 diagnosis of 999.4 for anaphylactic reaction to a vaccine or its components.
* Encephalopathy within 7 days of a previous dose of a pertussis containing vaccine not attributable to another identifiable cause
* Guillain-Barre- ICD-9 code is 357.0

Primary outcomes:
measure: Fully Vaccinated (Tdap, Menactra and 3 Doses of HPV (if Female))
timeFrame: 12 months
measure: Well Child Care Status
timeFrame: 12 months
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
affiliation: University of Rochester
name: Peter G Szilagyi, MD, MPH
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT00895388: Effects of Structured Rehabilitation Program on Quality of Life in Rectal Cancer Patients- a Randomized Controlled Trial
Official title: Effects of Structured Rehabilitation Program on Quality of Life After Surgical Treatment for Rectal Cancer- a Randomized Controlled Clinical Trial
Study type: INTERVENTIONAL
Overall status: WITHDRAWN
Phase: NA
Conditions: Quality of Life
Sexual Function
Urinary Incontinence
Anal Incontinence
Keywords: Urinary function
Anal function
Lead sponsor: University Hospital of North Norway
Sponsor class: OTHER
Collaborators: name: Helse Nord
First posted: 2009-05-08
Enrollment: 0
Sex: ALL
Minimum age (years): 18
Maximum age (years): 75
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: Quality of life after rectal surgery is reported to be impaired. Side effects of surgery and/or neoadjuvant treatment as functional disturbances like sexual dysfunction, urinary incontinence, anal incontinence or stoma problems are commonly experienced. The investigators hypotheses is that structured rehabilitation program addressing these problems will improve quality of life. A RCT are performed in order to document the effects of the rehabilitation.


Eligibility criteria: Inclusion Criteria:

* Rectal cancer Surgically treated for rectal cancer Informed concent Included in national guidelines for surveillance of rectal cancer patients

Exclusion Criteria:

* Older than 75 years Mentally or physically not able to participate Non curative surgical treatment

Primary outcomes:
measure: Quality of Life (EORTC QLQ-C30, EORTC QLQ-CR38)
timeFrame: Baseline, 3, 6, 12,18 and 24 months postoperative.
measure: Quality of LIfe (EQ 5D)
timeFrame: Baseline, 3,6,12, 18 and 24.
Secondary outcomes:
measure: St Marks incontinence
timeFrame: Baseline, 3, 12 and 24
measure: ICIQ sexual function
timeFrame: baseline, 3,12 and 24
measure: ICIQ Urinary function Short form
timeFrame: baseline,3, 12 and 24 months
Other outcomes:
Locations:
city: Tromsø
country: Norway
facility: Dep. of gastrointestinal surgery, University Hospital of North Norway
Study officials:
affiliation: Dep of gastrointestinal surgery, University Hospital of North Norway
name: Rolv-Ole Lindsetmo, MD, Phd, Mph
role: STUDY_DIRECTOR
References:
Clinical trial NCT06450288: Effectiveness of GO for Transitional Housing Residents
Official title: Effectiveness of the Green Oasis (GO) Wellness Program for Residents Living in Concordia Tsat Sing Kong Transitional Housing Estate
Study type: INTERVENTIONAL
Overall status: NOT_YET_RECRUITING
Phase: NA
Conditions: Quality of Life
Wellness, Psychological
Lead sponsor: The Hong Kong Polytechnic University
Sponsor class: OTHER
First posted: 2024-06-10
Enrollment: 50
Sex: ALL
Minimum age (years): 10
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: PREVENTION

Brief summary: The goal of this pre-post study is to enhance the health and wellness of the residents in the Concordia Tsat Sing Kong Transitional Housing Estate. This study aims to evaluate the effectiveness of the Green Oasis (GO) wellness program in:

1. Increase health awareness and engaging in health promoting activities, including more physical activities/walking, gardening.
2. Enhance happiness and quality of life.

Participants will:

* complete physical exercises, gardening, and interact with the GO website
* receive health talks


Eligibility criteria: Inclusion Criteria:

* Aged 10 or above.
* Scored \>6 in the Abbreviated Mental Test; a cut-off point of 6 is valid in differentiating between normal and abnormal cognitive functions for geriatric clients.
* Can understand Cantonese.
* Able to take part in light exercise and stretching.
* Have access to smartphone and internet.

Exclusion Criteria:

* Have a serious organic disease or malignant tumor.
* Have a mental disorder diagnosed by neurologists or psychiatrists.
* Experienced drug addiction

Primary outcomes:
measure: Quality of life (World Health Organization)
timeFrame: T0 (baseline), T1 (6 months), T2 (12 months)
measure: Happiness
timeFrame: T0 (baseline), T1 (6 months), T2 (12 months)
measure: Activities of daily living
timeFrame: T0 (baseline), T1 (6 months), T2 (12 months)
measure: Physical activity
timeFrame: T0 (baseline), T1 (6 months), T2 (12 months)
measure: Satisfaction with migration life
timeFrame: T0 (baseline), T1 (6 months), T2 (12 months)
measure: Pain intensity
timeFrame: T0 (baseline), T1 (6 months), T2 (12 months)
Secondary outcomes:
measure: Website evaluation
timeFrame: 2 weeks after T2 (post-test)
measure: Semi-structured interview
timeFrame: within 2 weeks after T2 (post-test)
Other outcomes:
Locations:
city: Hong Kong
country: Hong Kong
facility: Hong Kong Metropolitan University
Study officials:
References:
Clinical trial NCT05702788: Efficacy and Safety of Jaktinib in Participants With Severe Novel Coronavirus Pneumonia(COVID-19)
Official title: A Multicenter, Randomized, Double-blind, Placebo-parallel Controlled Study to Evaluate the Efficacy and Safety of Jaktinib Hydrochloride Tablets in Participants Receiving the Best Available Treatment for Severe Novel Coronavirus Pneumonia
Study type: INTERVENTIONAL
Overall status: WITHDRAWN
Phase: PHASE2
Conditions: COVID-19
Pneumonia
Lead sponsor: Suzhou Zelgen Biopharmaceuticals Co.,Ltd
Sponsor class: INDUSTRY
First posted: 2023-01-27
Enrollment: 0
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: This study adopts a randomized, double-blind, placebo parallel control design, and is expected to include 168 eligible patients with severe novel coronavirus pneumonia.


Eligibility criteria: Inclusion Criteria:

* 18 years of age, male or female;
* The Participants was diagnosed with novel coronavirus pneumonia;
* It meets the heavy-duty standards of the new coronavirus pneumonia diagnosis and treatment protocol (version 9).
* Participants who voluntarily sign informed consent.
* The National Institute of Allergy and Infectious Diseases Sequential Scale (NIAID-0S) score is 5 or 6;

Exclusion Criteria:

* Participants who cannot take orally, or are suspected to be allergic to Jaktinib, similar drugs or their excipients, or have severe gastrointestinal dysfunction that affects drug absorption;
* Participants who have received the following treatments within the specified time window before randomization:

  1. Participants have received Janus kinase (JAK) inhibitor, interleukin 6 (IL-6) inhibitor, IL-1 inhibitor, tumor necrosis factor (TNF) inhibitor, T cell or B cell depletion agent, interferon and other immunosuppressive drugs within the first two weeks of randomization, except glucocorticoid;
  2. Systematically used CYP 3A4 potent inhibitor or potent inducer in the first five drug half lives at random;
* Immune deficiency;

Primary outcomes:
measure: The proportion of Participants who develop death or respiratory failure.
timeFrame: 28 days after randomization
Secondary outcomes:
measure: The proportion of Participants who develop death or respiratory failure.
timeFrame: 14 days after randomization
Other outcomes:
Locations:
Study officials:
affiliation: The Third People Hospital of Shenzhen
name: Hongzhou Lu
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT05835388: The South Texas Aging Registry and Repository
Official title: The South Texas Aging Registry and Repository (STARR)
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Aging
Keywords: Older adults
Genetic material
Biorepository
Lead sponsor: The University of Texas Health Science Center at San Antonio
Sponsor class: OTHER
First posted: 2023-04-28
Enrollment: 149
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: OTHER
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Community dwelling adults from the South Texas area who are interested in volunteering for research studies on aging.

Brief summary: This research registry and repository was designed because the investigators want to learn about how to improve the health and quality of life of older adults.

Detailed description: The South Texas Aging Registry and Repository (STARR) is a database and specimen resource of community dwelling adults from the South Texas area who are interested in volunteering for research studies on aging. The goal is to assist in the inclusion of older adults in clinical research studies and to help to increase the quantity and quality of research relating to them. This registry and repository can be used for various purposes ranging from describing the natural history of aging, identifying risk factors for premature aging, and the real-world effectiveness of life-extending therapies. Collection and storage of biological samples and patient-reported data from of Individuals can help advance research and the development of new awareness of basic mechanisms that play a part in healthy aging or premature death.

Eligibility criteria: Inclusion Criteria STARR:

-Age 18 years or older

Inclusion Criteria KAPP Sen TMC:

-Age 20 years and older

Exclusion Criteria STARR:

* Inability to provide informed consent
* Pregnancy

Exclusion Criteria KAPP Sen Tissue Mapping Center (TMC) Study:

* Diabetes
* Hypertension with end-organ damage
* BMI\>30
* GFR\<60 ml/min/1.73 m2
* Cardiovascular disease
* Pancreatitis
* Malignancy other than non-melanoma skin cancers
* Active, uncontrolled pulmonary, hepatic, infectious, gastrointestinal, endocrine, neurologic, or inflammatory disease.
* Chronic use of systemic steroids or use of agents with senolytic activity
* Any disease or condition considered to be exclusionary based on the clinical option and discretion of PI

Primary outcomes:
measure: Collection of STARR repository data
timeFrame: Baseline to one day
Secondary outcomes:
measure: KAPP Sen TMC repository data
timeFrame: Baseline to one year
Other outcomes:
Locations:
city: San Antonio
country: United States
facility: The University of Texas Health Science Center at San Antonio
state: Texas
Study officials:
affiliation: University of Texas Health Science Center San Antonio
name: Sara Espinoza, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT01085188: Effectiveness of Assertive Continuing Care for Youth
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE3
Conditions: Substance Use Disorders
Lead sponsor: Chestnut Health Systems
Sponsor class: OTHER
Collaborators: name: National Institute on Alcohol Abuse and Alcoholism (NIAAA)
First posted: 2010-03-11
Enrollment: 342
Sex: ALL
Minimum age (years): 12
Maximum age (years): 18
Standard ages: CHILD
ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: FACTORIAL
Primary purpose: TREATMENT

Brief summary: Following discharge from residential treatment 324 adolescents are randomly assigned to Assertive Continuing Care with and without motivational incentives in a 2 x 2 factorial design. Clinical outcomes are assessed at 3, 6, 9, and 12 months post discharge.


Eligibility criteria: Inclusion Criteria:

* Met DSM-IV diagnostic criteria for abuse or dependence on alcohol or another drug in the past year
* Been between the ages of 12 and 18 at the time of residential admission; and (c) resided in one of ten Illinois counties targeted for the intervention

Exclusion Criteria:

* left residential treatment prior to the seventh day
* did not return to a target county at discharge
* showed evidence of cognitive impairment that interfered with understanding of study instruments, procedures, or the informed consent process
* were deemed dangerous to themselves or others during treatment
* were a ward of child protective services and inaccessible for the intervention
* met DSM-IV criteria for pathological gambling
* were discharged to the state department of corrections
* were already participating in a treatment study

Primary outcomes:
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
References:
Clinical trial NCT00390988: Capillary and Venous Blood Count Parameters
Official title: Comparison of Capillary and Venous Blood Count Parameters
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Hematological Diseases
Healthy Volunteers
Keywords: blood count
capillary
venous
Adult
reference values
Lead sponsor: University of Magdeburg
Sponsor class: OTHER
First posted: 2006-10-23
Enrollment: 250
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Time perspective: PROSPECTIVE

Brief summary: The purpose of this study is to compare capillary blood count parameters with the corresponding venous samples to verify the hypothesis that capillary and venous blood count parameters are equivalent.

Detailed description: In patients with haematological diseases regular blood count analyses are necessary. In haematology, capillary blood count analyses became established in routine diagnostics. The method and procedure of capillary blood sampling is well accepted by both the patients and the medical personal for a long time. However, only venous values are generally accepted in clinical routine. It is important to know whether or how capillary blood gives discrepant results for the various parameters. Values for therapeutic decisions, e.g. transfusion, are only known for venous values. So far, there are only deficient data available. Therefore, the aim of this study is (i) to compare capillary blood count parameters with the corresponding venous samples to verify the hypothesis that capillary and venous blood count parameters are equivalent, (ii) to include an adequate large number of adult haematological patients (with low and high values) and healthy adults, (iii) to obtain difference values for conversation of measured capillary values into the corresponding venous values.

Eligibility criteria: Inclusion Criteria:

* Patients with haematological diseases ≥18 years
* Healthy volunteers ≥18 years
* Informed consent
* No participation in another study 3 month before and during the study

Exclusion Criteria:

* Subjects \<18 years
* Healthy subjects with acute or chronic infections and autoimmune or malignant diseases

Primary outcomes:
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
affiliation: University Hospial Magdeburg, Division of Haematoloy/Oncology, Leipziger Str. 44, D-39120 Magdeburg, Germany
name: Kathleen Jentsch-Ullrich, Dr.
role: PRINCIPAL_INVESTIGATOR
References:
citation: Schalk E, Heim MU, Koenigsmann M, Jentsch-Ullrich K. Use of capillary blood count parameters in adults. Vox Sang. 2007 Nov;93(4):348-53. doi: 10.1111/j.1423-0410.2007.00978.x.
citation: Schalk E, Scheinpflug K, Mohren M. Correlation of capillary and venous absolute neutrophil counts in adult hematological patients and normal controls. Am J Hematol. 2008 Jul;83(7):605. doi: 10.1002/ajh.21163. No abstract available.