Clinical trial NCT02919085: Effect of Critical Patients Mobilization on Respiratory and Peripheral Muscle Strength and Functional Capacity.
Official title: Effect of Spontaneously Breathing Critical Patients Mobilization on Respiratory and Peripheral Muscle Strength and Functional Capacity.
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Intensive Care Unit Syndrome
Muscle Weakness
Lead sponsor: Universidade Federal de Pernambuco
Sponsor class: OTHER
First posted: 2016-09-29
Enrollment: 40
Sex: ALL
Minimum age (years): 18
Maximum age (years): 80
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: TREATMENT

Brief summary: To analyze changes on respiratory muscle strength, peripheral and functional capacity of critically ill patients with clinical and surgical etiology, breathing spontaneously and bedridden, within 48 hours of admission to the intensive care unit (ICU) and if there are correlations among these variables. This is an observational study. Respiratory muscle strength will be assessed through the maximum inspiratory pressure (MIP) and maximal expiratory pressure (MEP) and peripheral muscle strength, by the Medical Research Council score (MRC) and hand grip test and functional capacity through the Functional Independence Measure (FIM) and Physical Function ICU Test Score (PFIT-s) in the period between 24h and 48h of hospitalization in the adult ICU. For descriptive purposes, the sample will be stratified according to clinical and surgical characteristics. Correlations will be determined using the Pearson test, with significance level of p \<0.05.


Eligibility criteria: Inclusion Criteria:

* Breathing spontaneously
* Length of stay in ICU greater than 24 hours
* Adherence to study

Exclusion Criteria:

* Patients with poor prognosis or palliation;
* Preexisting neuromuscular diseases;
* Immobility or restriction to bed prior to admission;
* Nonunions and amputations;
* Osteomioarticular, cognitive or neurological impairment;
* Non-cooperation;
* Specific contraindications to the application of evaluation methods;
* Hemodynamic or respiratory instability within 48 hours of ICU admission preventing evaluation muscle strength and functional capacity.

Primary outcomes:
measure: Respiratory muscle strength
timeFrame: 48 hours
measure: Peripheral muscle strength
timeFrame: 48 hours
measure: Functional capacity
timeFrame: 48 hours
Secondary outcomes:
Other outcomes:
Locations:
city: Recife
country: Brazil
facility: Real Hospital Português de Beneficência
state: Pernambuco
Study officials:
affiliation: Universidade Federal de Pernambuco
name: Maria KF Richtrmoc
role: PRINCIPAL_INVESTIGATOR
References:
citation: Williams TA, Dobb GJ, Finn JC, Webb SA. Long-term survival from intensive care: a review. Intensive Care Med. 2005 Oct;31(10):1306-15. doi: 10.1007/s00134-005-2744-8. Epub 2005 Aug 24.
citation: Rossi PJ, Edmiston CE Jr. Patient safety in the critical care environment. Surg Clin North Am. 2012 Dec;92(6):1369-86. doi: 10.1016/j.suc.2012.08.007. Epub 2012 Oct 6.
citation: Neideen T. Monitoring devices in the intensive care unit. Surg Clin North Am. 2012 Dec;92(6):1387-402. doi: 10.1016/j.suc.2012.08.010. Epub 2012 Oct 13.