Clinical trial NCT01504828: Cardiac Energetics and Function in Normal Human Ageing
Official title: Cardiac Energetics and Function in Normal Human Ageing
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Left Ventricular Function Systolic Dysfunction
Left Ventricular Function Diastolic Dysfunction
Ageing
Keywords: Energy Metabolism
Ageing
left ventricle
energetics
function
Lead sponsor: Newcastle-upon-Tyne Hospitals NHS Trust
Sponsor class: OTHER
First posted: 2012-01-05
Enrollment: 135
Sex: ALL
Minimum age (years): 20
Maximum age (years): 80
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: BASIC_SCIENCE

Brief summary: Normal aging is characterized by altered cardiovascular function. Our preliminary data with MR imaging and spectroscopy in normal subjects without cardiovascular disease or hypertension show that age-related cardiac dysfunction is characterized initially by impaired relaxation of the heart (40 - 60 years), and then at \> 60 years altered contraction and impaired myocardial energetics. For the first time, the investigators will test whether the functional and energetic effects of normal aging can be reversed by acutely reducing stiffness of peripheral blood vessels using an ACE inhibitor. This will potentially have important insights into how normal aging affects the heart, and how potential treatments could be used to attenuate this process.

Detailed description: Normal aging is characterized by altered cardiovascular function. Our preliminary data with MR imaging and spectroscopy in normal subjects without cardiovascular disease or hypertension show that age-related cardiac dysfunction is characterized initially by diastolic dysfunction (40 - 60 years), and then at \> 60 years altered systolic strains and impaired myocardial energetics. The investigators propose to study the mechanism of these findings in subjects with normal aging without any cardiovascular disease, hypothesizing that increased vascular stiffening contributes to impaired energetics and left ventricular function. For the first time, the investigators will test whether the functional and energetic effects of normal aging can be reversed by acutely reducing afterload using an ACE inhibitor. This will be tested at 2 ages (40-60 and \> 60 years), so that the intervention tests the hypothesis soon after the abnormalities develop (40-60 years - diastolic dysfunction; \> 60 years energetics and altered strains). This will potentially have important insights into how normal aging affects the heart, and how potential treatments could be used to attenuate this process.

Eligibility criteria: Inclusion Criteria:

* Male and female subjects between the ages of 20 and 80 years

Exclusion Criteria:

* Any cardiovascular condition including hypertension, or on any cardiovascular therapy.
* Blood Pressure \> 150 mmHg systolic, and/or \> 90 mmHg diastolic
* Claustrophobia
* Implanted metal prosthesis
* Chronic renal failure requiring dialysis
* Diabetes mellitus.

Primary outcomes:
measure: Vascular Stiffness
timeFrame: 2 Hours - Acute study with no follow-up
measure: Left Ventricular Energetics
timeFrame: 2 hours - Acute Study, no follow-up
measure: Left Ventricular Function
timeFrame: 2 hours - Acute Study, no follow-up
Secondary outcomes:
measure: Effects of ACE inhibitor on left ventricular energetics and function in those subjects aged 40 and over
timeFrame: 6 hours - Acute study, no follow-up
Other outcomes:
Locations:
city: Newcastle upon Tyne
country: United Kingdom
facility: Campus for Ageing and Vitality
Study officials:
affiliation: Freeman Hospital, Newcastle upon Tyne and Newcastle University
name: Guy A MacGowan, MD
role: PRINCIPAL_INVESTIGATOR
References:
citation: Hollingsworth KG, Blamire AM, Keavney BD, Macgowan GA. Left ventricular torsion, energetics, and diastolic function in normal human aging. Am J Physiol Heart Circ Physiol. 2012 Feb 15;302(4):H885-92. doi: 10.1152/ajpheart.00985.2011. Epub 2011 Dec 16.
citation: Parikh JD, Hollingsworth KG, Kunadian V, Blamire A, MacGowan GA. Measurement of pulse wave velocity in normal ageing: comparison of Vicorder and magnetic resonance phase contrast imaging. BMC Cardiovasc Disord. 2016 Feb 19;16:50. doi: 10.1186/s12872-016-0224-4.