louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT06691841: Effect of Chlorhexidine Gluconate in Oral Care of Patients With Endotracheal Intubation Based on 16sRNA Technology
Official title: Effect of Chlorhexidine Gluconate in Oral Care of Patients With Endotracheal Intubation Based on 16sRNA Technology
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Intubation, Endotracheal
Oral Hygiene
Keywords: Chlorhexidine Gluconate
Endotracheal Intubation
16sRNA
Lead sponsor: Shanghai 10th People's Hospital
Sponsor class: OTHER
First posted: 2024-11-15
Enrollment: 76
Sex: ALL
Minimum age (years): 65
Standard ages: OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: PREVENTION

Brief summary: Evaluation of the application effect of compound chlorhexidine gargle in oral care of patients with endotracheal intubation based on 16s RNA technology.

Detailed description: Evaluation of the application effect of compound chlorhexidine gargle in oral care of patients with endotracheal intubation based on 16s RNA technology. Between September 2022 and March 2023, 68 patients admitted to the ICU for endotracheal intubation were collected. They were randomly divided into intervention group and control group, with 34 cases in each group. The control group used the method of wiping, washing and saline (0.9%) three times a day, and the intervention group was using the method of wiping, washing and 0.12% chlorhexidine gluconate three times a day.The results were analyzed at three time points before the first oral care after intubation, before oral care 48 hours after intubation, and before oral care on the 5th day after intubation.

Eligibility criteria: Inclusion Criteria:

* Age ≥ 65 years; ② Complete clinical data; ③ Expected duration of orotracheal intubation for mechanical ventilation exceeding 5 days.

Exclusion Criteria:

* Patients with abnormal coagulation function, severe respiratory burns, oral surgery, lung and systemic infections; ② Patients expected to die within 48 hours after extubation; ③ Patients with actual duration of orotracheal intubation for mechanical ventilation less than 5 days.

Exclusion During Study:

* Failure to follow the prescribed plan; ② Incomplete data; ③ Patients who voluntarily withdraw from treatment during the study.

Primary outcomes:
measure: Changes in the oral microbiota
timeFrame: Immediately after enrollment; 48 hrs after intubation；5 days after intubation
Secondary outcomes:
measure: oral complications
timeFrame: mechanical ventilation at 0 hours, 2 days, and 5 days post-intervention
measure: plaque Index
timeFrame: mechanical ventilation at 0 hours, 2 days, and 5 days post-intervention
measure: whether VAP occurs
timeFrame: Immediately after enrollment; 48 hrs after intubation；5 days after intubation
measure: 28-day mortality rate
timeFrame: 28 days post-randomization
Other outcomes:
Locations:
city: Shanghai
country: China
facility: Changcui Qiu
Study officials:
affiliation: Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, China
name: sheng wang, PHD
role: STUDY_DIRECTOR
References:
Clinical trial NCT01073241: Transurethral Ventral Wall of Urethra-preserving Enucleation of Prostate
Official title: Transurethral Ventral Wall of Urethra-preserving Enucleation of Prostate
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Benign Prostatic Hyperplasia
Keywords: benign prostatic hyperplasia
Transurethral Resection of Prostate
transurethral enucleation of prostate
Lead sponsor: Southwest Hospital, China
Sponsor class: OTHER
First posted: 2010-02-23
Enrollment: 200
Sex: MALE
Minimum age (years): 45
Maximum age (years): 90
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: In this study, the investigators designed a randomized and double-blind prospective trial to evaluate the efficiency and safety of the investigators new approach-transurethral ventral wall of urethra-preserving enucleation of prostate in comparison with TURP for the hyperplasia weighing more than 45 g.

Detailed description: Although in recent dozen of years, laser operation and other safer minimally invasive surgeries have been well-developed, transurethral resection of the prostate (TURP) is still the gold standard for the surgical treatment of benign prostatic hyperplasia, despite of its various complications, and not suitable for the hyperplasia over 80 g which should be resected under open surgery. In this study, we design a randomized and double-blind prospective trial to evaluate the efficiency and safety of our new approach-transurethral ventral wall of urethra-preserving enucleation of prostate in comparison with TURP for the hyperplasia weighing more than 45 g.Urodynamic examination \[maximum flow rate (QMax), detrusor pressure, and so on\], transrectal color Doppler ultrasonography for the prostate, blood routine, blood electrolyte, prostate specific antigen (PSA), International Prostate Symptom Score (IPSS), the quality of life (Qol), blood loss during operation, and the weight of resected prostate were studied before and after the operation.

Eligibility criteria: Inclusion Criteria:

* BPH was diagnosed by DRE, Ultrasonography, CT or MR
* IPSS:\>15
* Qmax:≤10ml/s and volume of bladder \>200ml
* The weight of prostate \>45g

Exclusion Criteria:

* Patient with other aggravating malignant tumor
* Total-PSA\>20ng/ml, or 4\<total-PSA\<20ng/ml but the value of Free-PSA/total-PSA\<0.16
* The maximum press of detrusor muscle \<15cmH2O
* Patient with urethral stricture
* Patient with urinary infection
* Patient with Nervous System Disease
* Patient with surgical contraindication, such as severe cardiac or lung disease, diaphragmatic hernias, and so on

Primary outcomes:
measure: urodynamic study
timeFrame: before operation and the third month, 6th month after operation
Secondary outcomes:
Other outcomes:
Locations:
city: Shapinba
country: China
facility: Department of Urology, Southwest Hospital
state: Chongqin
Study officials:
affiliation: Urology Institute of Southwest Hospital, Chongqin, China
name: Zhang Jiahua
role: STUDY_DIRECTOR
References:
Clinical trial NCT01447641: Sleep, Circadian Rhythms and Cluster Headache
Official title: Characterisation of Sleep and Circadian Physiology in Individuals With Cluster Headache
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Cluster Headache
Keywords: Cluster Headache
Trigeminal Autonomic Cephalalgias
Sleep
Circadian Rhythms
Lead sponsor: University of Surrey
Sponsor class: OTHER
Collaborators: name: University of California, San Francisco
First posted: 2011-10-06
Enrollment: 8
Sex: ALL
Minimum age (years): 16
Maximum age (years): 75
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: CASE_CROSSOVER
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Cluster headache sufferers (both of the episodic and chronic cluster headache) Related headache disorders

Brief summary: The purpose of this study is to assess both the sleep and circadian (24-hourly biological rhythms) physiology of people with cluster headache. For sufferers with the episodic form of the disorder this will involve observation at two separate time points, once when experiencing attacks (in-bout) and once when attack free (out-of-bout).

The study will include measurement of basic rest-activity patterns, sleep timing and timing of individual attacks, as well as a more detailed study recording sleep and circadian rhythms under clinical conditions over consecutive nights.

Studying the differences in these processes in single individuals when they are both experiencing and free from attacks might provide insight into the brain mechanisms involved in triggering the bouts of attacks and individual attacks themselves. An improved understanding of this area may help design improved treatment options in future.


Eligibility criteria: Inclusion Criteria:

* Diagnosis of cluster headache or closely related primary headache disorder

Exclusion Criteria:

* Abnormality on screening investigations that increase risk of participation
* Alcohol consumption exceeding 21 units per week

Primary outcomes:
measure: amplitude and phase of circadian rhythm of melatonin
timeFrame: 36 hours
Secondary outcomes:
Other outcomes:
Locations:
city: Guildford
country: United Kingdom
facility: Surrey Clinical Research Centre, University of Surrey
Study officials:
affiliation: University of Surrey
name: Alexander D Nesbitt, BM BCh MRCP
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT00078741: Cognitive Behavioral Therapy for Post-Traumatic Stress Disorder in Individuals With Severe Mental Illness
Official title: CBT for PTSD and SMI in Community Mental Health Centers
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE2
Conditions: Stress Disorders, Post-Traumatic
Schizophrenia
Keywords: Psychotic Disorders
Lead sponsor: Medical University of South Carolina
Sponsor class: OTHER
Collaborators: name: National Institute of Mental Health (NIMH)
First posted: 2004-03-08
Enrollment: 60
Sex: ALL
Minimum age (years): 18
Maximum age (years): 80
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NON_RANDOMIZED
Intervention model: SINGLE_GROUP
Primary purpose: TREATMENT

Brief summary: This study will develop a cognitive behavioral therapy (CBT) program to treat symptoms of post-traumatic stress disorder (PTSD) in people with severe mental illnesses who are treated within community mental health systems.

Detailed description: A significant proportion of people with SMI who are treated within the public sector also suffer from PTSD. Evidence suggests that these individuals often receive inadequate mental health services because effective treatments have not been explored. This study will develop and implement a CBT treatment that is designed specifically for the SMI/PTSD population.

In the first year of the study, a treatment manual and a CBT treatment model, including education, social skills training, and exposure therapy, will be developed. In the following two years, the treatment program will be tested in individuals with SMI and PTSD. Scale ratings, self-report checklists, and daily logs of behavior will be used to assess PTSD symptoms. Scale ratings and self-report surveys will also be used to measure hostility, functional status, depression and schizophrenia symptoms, and satisfaction with the study. Assessments will be made throughout the study.

Eligibility criteria: Inclusion Criteria:

* Diagnosis of PTSD and schizophrenia or schizoaffective disorder
* Active involvement in case management

Exclusion Criteria:

* Suicide risk

Primary outcomes:
Secondary outcomes:
Other outcomes:
Locations:
city: Charleston
country: United States
facility: Medical University of South Carolina
state: South Carolina
city: Columbia
country: United States
facility: South Carolina Department of Mental Health
state: South Carolina
Study officials:
affiliation: Medical University of South Carolina
name: Christopher Frueh
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT04279041: In-vitro and In-vivo Comparative Evaluation of Rotary Fanta and Zunba Files in Root Canal Preparation of Infected Primary Molars
Official title: In-vitro and In-vivo Comparative Evaluation of Rotary Fanta and Zunba Files in Root Canal Preparation of Infected Primary Molars
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Root Canal Preparation of Infected Primary Molars
Lead sponsor: Minia University
Sponsor class: OTHER
First posted: 2020-02-20
Enrollment: 98
Sex: ALL
Minimum age (years): 4
Maximum age (years): 7
Standard ages: CHILD
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: Adequate shaping and cleaning, followed by a good coronal seal, are prerequisites for a favorable outcome. The goal of root canal preparation is to create optimized canal geometry to allow effective irrigation and obturation with preservation of the original canal morphology.

The aim of current study is to evaluate the effectiveness of Fanta and Zunba rotatory instruments in cleaning of infected root canal of primary molars to those instrumented with manual K-files.


Eligibility criteria: Inclusion Criteria:

* Class I or II according to American Society of Anesthesiologists (ASA)
* Necrotic pulp tissues which may be asymptomatic or manifested with dull ache pain
* Pathological tooth mobility
* Percussion sensitivity
* Swelling close to involved tooth accompanied with or without fistula
* The extension of radiolucency at the furcation area did not exceed half of the space between the furcation and the permanent successor
* No internal root resorption
* External root resorption (Physiologic or pathologic) limited to apical third and with at least two-third root intact

Exclusion Criteria:

* Uncooperativeness of child and/or parents or caregiver's behavior.
* Unrestorable tooth.
* Presence of calcific metamorphosis inside root canals.

Primary outcomes:
measure: clinical success rate
timeFrame: 12 month
measure: radiographic success rate
timeFrame: 12 month
Secondary outcomes:
Other outcomes:
Locations:
city: Minya
country: Egypt
facility: Minia University
Study officials:
References:
Clinical trial NCT06277141: The Vitality Mammography Messaging Study
Official title: The Vitality Mammography Study - Testing the Effectiveness of a Booking Platform on Receipt of Screening Mammography - a Randomized Controlled Trial.
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Breast Cancer Female
Keywords: Mammography
Screening
Social Media
Lead sponsor: Wits Health Consortium (Pty) Ltd
Sponsor class: OTHER
Collaborators: name: Discovery Vitality
First posted: 2024-02-26
Enrollment: 7655
Sex: FEMALE
Minimum age (years): 50
Maximum age (years): 75
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Intervention model description: Randomized controlled trial
Primary purpose: SCREENING

Brief summary: The investigators will be conducting a randomized controlled trial amongst members of a Wellness Program to test receipt of mammogram using the Whatsapp social media platform and testing various messages.

Detailed description: The investigators will be conducting a randomised control trial to test the efficacy of WhatsApp messages to increase receipt of mammography amongst eligible women who are members of the Vitality health promotion programme and are also on the Discovery Health Medical Scheme. The study will test a message that 1) has a link to a platform created by the Radiology Society of South Africa which allow members to select a range of practices to book a mammogram, against 2) a message that gives names and telephone numbers of Radiology practices in a 5 km radius of the members home address, against 3) a group with a link to an online platform as well as telephone numbers of radiology practices, against 4) a group where a standard message reminding to go for mammogram will be sent, but without names and telephone numbers of the radiology practices, against 5) a control group where no messages relating to mammography will be sent.

Eligibility criteria: Inclusion Criteria:

* Females aged 50 to 75 years, who are members of the Discovery Health Medical Plan and who are also members of Vitality and who have not had a screening mammogram in the preceding three years and who have not previously been diagnosed with breast cancer.

Exclusion Criteria:

* CPA Blocks
* If member's address location, based on their Discovery profile, was further than 5km radius to the Radiologist practice

Primary outcomes:
measure: Comparison of mammography screening rates using WhatsApp
timeFrame: Five months
Secondary outcomes:
Other outcomes:
Locations:
city: Johannesburg
country: South Africa
facility: University of Witwatersrand
state: Gauteng
Study officials:
affiliation: Discovery
name: Adele Walker
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT04848441: Risk of COVID-19 Infection After Vaccination
Official title: Risk of COVID-19 Infection After Vaccination: A Nationwide Study Comparing BNT162b2, mRNA-1273 and ChAdOx1
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Vaccination; Infection
Covid19
Keywords: COVID-19
Vaccination
Nationwide observational study
Lead sponsor: Umeå University
Sponsor class: OTHER
First posted: 2021-04-19
Enrollment: 2000000
Sex: ALL
Minimum age (years): 0
Maximum age (years): 110
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: RETROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: The study population will contain all Swedish citizens vaccinated with BNT162b2, mRNA-1273 or ChAdOx1, all Swedish citizens diagnosed with COVID-19, and a control group matched 1:1 on birth year, sex and municipality to the first two groups.

Brief summary: The purpose of this observational nationwide study is to evaluate the effects of three different COVID-19 vaccines for the outcome of different severities of incident COVID infection.


Eligibility criteria: Inclusion Criteria:

* Living in Sweden and vaccinated with BNT162b2, mRNA-1273 or ChAdOx1
* All individuals with a previous COVID-19 infection
* Controls matched 1:1 to the groups above

Exclusion Criteria:

* None

Primary outcomes:
measure: Incident COVID-19 infection
timeFrame: Up to six months after vaccination
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
References:
Clinical trial NCT04812041: Relationship Between Delirium Severity by CAM-ICU 7 and 4C Mortality Score of the COVID-19 Patients in ICU
Official title: Relationship Between Delirium Severity by CAM-ICU 7 and 4C Mortality Score of the COVID-19 Patients in ICU
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Delirium
Covid19
Intensive Care Unit Delirium
Lead sponsor: Ankara City Hospital Bilkent
Sponsor class: OTHER
First posted: 2021-03-23
Enrollment: 150
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: CROSS_SECTIONAL
Sampling method: PROBABILITY_SAMPLE
Study population: Patients hospitalized in the intensive care unit diagnosed with COVID-19 will participate in the study.

Brief summary: Aim: to investigate whether the 4C Mortality score, which measures the severity of COVID-19, and the CAM-ICU 7 score , which measures the severity of delirium, in ICU. To compare two scores in terms of the number of days without intubation and 28 day mortality rates in ICU.


Eligibility criteria: Inclusion Criteria:Patients hospitalized in the intensive care unit diagnosed with COVID-19 will include in the study

Exclusion Criteria:there is no exclusion criteria

Primary outcomes:
measure: 28 day mortality
timeFrame: 28 days
Secondary outcomes:
Other outcomes:
Locations:
city: Ankara
country: Turkey
facility: Ankara City Hospital
Study officials:
affiliation: ankara ch bilkent
name: betül aytaç, MD
role: STUDY_CHAIR
References:
citation: Khan BA, Perkins AJ, Gao S, Hui SL, Campbell NL, Farber MO, Chlan LL, Boustani MA. The Confusion Assessment Method for the ICU-7 Delirium Severity Scale: A Novel Delirium Severity Instrument for Use in the ICU. Crit Care Med. 2017 May;45(5):851-857. doi: 10.1097/CCM.0000000000002368.
citation: Knight SR, Ho A, Pius R, Buchan I, Carson G, Drake TM, Dunning J, Fairfield CJ, Gamble C, Green CA, Gupta R, Halpin S, Hardwick HE, Holden KA, Horby PW, Jackson C, Mclean KA, Merson L, Nguyen-Van-Tam JS, Norman L, Noursadeghi M, Olliaro PL, Pritchard MG, Russell CD, Shaw CA, Sheikh A, Solomon T, Sudlow C, Swann OV, Turtle LC, Openshaw PJ, Baillie JK, Semple MG, Docherty AB, Harrison EM; ISARIC4C investigators. Risk stratification of patients admitted to hospital with covid-19 using the ISARIC WHO Clinical Characterisation Protocol: development and validation of the 4C Mortality Score. BMJ. 2020 Sep 9;370:m3339. doi: 10.1136/bmj.m3339.
Clinical trial NCT07010848: the Efficacy of Core Stability Training in Rehabilitation
Official title: The Efficacy of Core Stability Training in Rehabilitation of Patients After Hip Fracture and in Patients After Stroke
Study type: OBSERVATIONAL
Overall status: NOT_YET_RECRUITING
Conditions: Stroke
Hip Fractures
Lead sponsor: Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Sponsor class: OTHER
First posted: 2025-06-08
Enrollment: 80
Sex: ALL
Minimum age (years): 18
Maximum age (years): 90
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: The study selects geriatric patients tha need rehabilitation after hip fracture and after stroke.

Brief summary: The goal of the study is to verify the efficacy of core stability training in rehabilitation of patients after hip fracture and in patients after stroke.

The study will compare one group using traditional rehabilitation and another one with the addiction of an approach named "Omino", which is a kind of "health education" for the patient to the use of "Core Stability".


Eligibility criteria: Inclusion Criteria:

* age:18/90
* hip fracture
* stroke
* Consensus released

Exclusion Criteria:

* MMSE\<24
* Dementia
* No Trunk control
* no deambulation
* clinical reasons
* consensus not released.

Primary outcomes:
measure: Ability in deambulation
timeFrame: 1 year
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
affiliation: Fondazione Policlinico universitario Agostino Gemelli IRCSS
name: maria chiara patriarca
role: PRINCIPAL_INVESTIGATOR
References: