Clinical trial NCT05439317: Elasticity of the Hoffa's Fat Pad in Patients With Knee Osteoarthritis
Official title: Elasticity of the Hoffa's Fat Pad in Patients With Knee Osteoarthritis
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Knee Osteoarthritis
Elasticity Imaging Techniques
Lead sponsor: Taipei Veterans General Hospital, Taiwan
Sponsor class: OTHER_GOV
First posted: 2022-06-30
Enrollment: 33
Sex: ALL
Minimum age (years): 20
Maximum age (years): 86
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: OTHER
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: individuals with knee osteoarthritis diagnosis is classified as K-L grading I - IV individuals in control group has no knee pain or osteoarthritis history

Brief summary: Knee osteoarthritis (OA) is a common problem in clinical settings. Knee OA is well known for its association with the wear and tear of the cartilage and osteophyte formation. Evidence has suggested the importance of the infrapatellar fat pad, known as Hoffa's fat pad, during the development of knee OA. Some studies have demonstrated the protective role of the infrapatellar fat pad, whereas others have suggested an inflammatory role such as increased fibrosis and proinflammatory cytokine levels. Ultrasound is exceptionally convenient in the assessment of the musculoskeletal system, and elastography is a tool to evaluate tissue texture. Therefore, in this study, we investigated the Hoffa's fat pad in knee OA patients by using elastography.

Detailed description: This was an observation study that included a control group. We enrolled 20 patients with knee OA, as well as 10 healthy individuals. The Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) and Kellgren-Lawrence X-ray grading were employed to determine disease severity. All the study participants received elastography assessment, including strain and shear wave elastography in the knee extension and flexion position. The strain elastography contained color mapping that enabled the calculation of the relative texture and strain ratio. The shear wave elastography revealed the qualitative velocity, which was measured 3 times. Each patients with knee OA received elastography examination twice: once before hyaluronic acid injection and once 1 month after the injection.

Eligibility criteria: Inclusion Criteria:

OA group

* Kellgren-Lawrence grading I-IV proved by knee X-ray Healthy group
* No knee pain or received injection during the past 1 year
* No history of knee OA

Exclusion Criteria:

* History of knee surgery, trauma or malignancy
* History of patellar tendinopathy or patellofemoral pain syndrome
* Refused informed consent

Primary outcomes:
measure: shear modulus
timeFrame: before and 1-3 months after hyaluronic acid injection
measure: strain ratio
timeFrame: before and 1-3 months after hyaluronic acid injection
measure: thickness of Hoffa's fat pad
timeFrame: before and 1-3 months after hyaluronic acid injection
Secondary outcomes:
Other outcomes:
Locations:
city: Taipei
country: Taiwan
facility: Taipei Veterans General Hospital
Study officials:
affiliation: Physical and Rehabilitation Medicine, Veterans General Hospital
name: Ding-Hao Liu
role: STUDY_CHAIR
References: