Clinical trial NCT06721793: The Impact of a Caffeinated Sports Drink on Performance
Official title: The Impact of a Caffeinated Sports Drink on Performance
Study type: INTERVENTIONAL
Overall status: RECRUITING
Phase: NA
Conditions: Dehydration
Dehydration Related to Exercise
Keywords: caffeine
sports drinks
hydration
Lead sponsor: Arizona State University
Sponsor class: OTHER
First posted: 2024-12-06
Enrollment: 20
Sex: ALL
Minimum age (years): 18
Maximum age (years): 55
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: CROSSOVER
Intervention model description: Counter balanced cross-over design trial with 4 arms differing only on the type of drink consumed during exercise.

Each trial includes 2 hours of cycling in a warm environment (32ºC), followed by strength and cognitive assessments.
Primary purpose: BASIC_SCIENCE

Brief summary: Caffeine is known to enhance physical and mental performance, but few beverages combine caffeine with electrolytes and carbohydrates to enhance exercise performance. This study evaluates a caffeinated electrolyte-glucose drink's effect on endurance, strength, and cognition. Using a repeated-measures, cross-over design, 20 trained cyclists will complete one familiarization and four randomized 3-hour experimental trials (Liquid I.V.™ Energy Multiplier, Hydration Multiplier, Sugar-Free Hydration Multiplier, and water). Each trial includes 2 hours of cycling in a warm environment (32ºC), followed by strength and cognitive assessments. Cycling performance, capillary blood, urine, and expiratory gases will be collected.

Detailed description: Each subject will complete 5 trials (1 familiarization and 4 experimental) consisting of approximately 2 hours cycling in a warm environment (90ºF), followed by strength assessment and cognitive assessment via questionnaire. Each trial will be identical, with the only difference being the type of drink consumed during each trial. The first trial will be for familiarization without any blood sampling. The rest of the trials will be completed in a randomized order and the drink consumed

Cycling Endurance Exercise Performance

The exercise test will consist of a series of three consecutive cycling sets in a warm environment (90ºF), with each series consisting of:

1. a 30-min submaximal ride (50% maximal power as determined from the initial)
2. a 5-km time trial race-like performance effort. During each 30 min submaximal rides participants will drink a total 500 mL of fluid spread out during the 30 min. During the 5 km performance test the participants will drink 25 mL of fluid at the end of each kilometer.

At regular intervals throughout the exercise task, body weight, blood samples, respiratory gasses, and perceptual data will be collected. See study schematic provided below for specific measurement timepoints.

Upon completion of the cycling task subjects will moved to another room with cool temperature (70ºF), where strength and cognitive function will be assessed to determine the influence of each beverage on indices of exercise performance and fatigue.

Eligibility criteria: Inclusion Criteria:

* Age 18-55
* Healthy and injury-free (muscle, skeletal) for greater than 2 months
* Active cyclists who train at least 3 times per week
* Body mass index (BMI) range of 18.5-30 kg/m2

Exclusion Criteria:

* • History of caffeine sensitivity

  * Cancer Diagnosis during the last 5 years
  * Pregnancy
  * History of renal disease, hypertension
  * History of a heat stroke
  * Use of testosterone therapy
  * Adults who are unable to consent (impaired decision-making capacity)

Primary outcomes:
measure: 5 kilometer cycling time trial
timeFrame: During the 3rd time trial which is the last time trial.
measure: 5 kilometer Time trial performance
timeFrame: 2nd time trial
measure: Isokinetic stregth
timeFrame: right after the cycling tests
measure: Congitive performance 1
timeFrame: after the completion of strength test
measure: Cognitive performance 2
timeFrame: after the end of the strength assessment
measure: Congitive test 3
timeFrame: right after the strength test
Secondary outcomes:
measure: Blood glucose
timeFrame: at the end of the 3rd cycling time trial.
Other outcomes:
Locations:
city: Phoenix
country: United States
facility: Arizona State University - Hydration Science Lab
state: Arizona
Study officials:
affiliation: Arizona State University
name: Stavros Kavouras, PhD
role: PRINCIPAL_INVESTIGATOR
References: