Clinical trial NCT03670589: Vestibular Evaluation After Vestibular Schwannoma Treatment
Official title: Vestibular Evaluation Before and After Treatment of Vestibular Schwannoma. Comparison of Gamma Knife Radiosurgery and Microsurgical Resection
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Dizziness
Keywords: vestibular schwannoma
gammaknife radiosurgery
vestibular evaluation
Lead sponsor: University Hospital, Grenoble
Sponsor class: OTHER
First posted: 2018-09-13
Enrollment: 51
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: CASE_CONTROL
Time perspective: RETROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: The popultaion include patients treated by gamaknife radiosurgery or microsurgery resection for a one side vestibular schwannoma between 01/01/2012 and 31/12/2017, follow at the Grenoble University Hospital

Brief summary: Vestibular schwannoma is a benign tumor located on the vestibular nerve. Patient could present dizziness symptoms cause to the tumor, and at least after the treatment by gamaknife radiosurgery or microsurgery resection.

Only few studies keep the interest about dizziness symptoms and treatment modality in vestibular schwannoma.

In the study dizziness symptoms were compared before and after the treatment of vestibular schwannoma by radiosurgery gammaknife or microsurgery resection. 2 scales were used : dizziness handicap inventory (DHI) and dizziness functionnal scale (AAO).


Eligibility criteria: Inclusion Criteria:

* patient treated of an one side vestibular schwannoma between 01/01/2012 and 31/12/2017, follow at the Grenoble University Hospital
* treatment : gamaknife radiosurgery or microsurgery resection
* no opposition of the patient

Exclusion Criteria:

* association of gamaknife radiosurgery and microsurgery resection
* bilateral vestibular schwannoma

Primary outcomes:
measure: Vestibular evaluation DHI
timeFrame: From 4 years to 6 months
measure: Vestibular evaluation AAO
timeFrame: From 4 years to 6 months
Secondary outcomes:
measure: Facial fonction
timeFrame: From 4 years to 6 months
measure: Hearing function
timeFrame: From 4 years to 6 months
measure: Tumor control
timeFrame: From 4 years to 6 months
Other outcomes:
Locations:
city: La Tronche
country: France
facility: CHU Grenoble-Alpes
Study officials:
References:
citation: Carlson ML, Tveiten OV, Driscoll CL, Neff BA, Shepard NT, Eggers SD, Staab JP, Tombers NM, Goplen FK, Lund-Johansen M, Link MJ. Long-term dizziness handicap in patients with vestibular schwannoma: a multicenter cross-sectional study. Otolaryngol Head Neck Surg. 2014 Dec;151(6):1028-37. doi: 10.1177/0194599814551132. Epub 2014 Oct 1.
citation: Park CE, Park BJ, Lim YJ, Yeo SG. Functional outcomes in retrosigmoid approach microsurgery and gamma knife stereotactic radiosurgery in vestibular schwannoma. Eur Arch Otorhinolaryngol. 2011 Jul;268(7):955-9. doi: 10.1007/s00405-011-1596-9. Epub 2011 Apr 11.
citation: Pollock BE, Driscoll CL, Foote RL, Link MJ, Gorman DA, Bauch CD, Mandrekar JN, Krecke KN, Johnson CH. Patient outcomes after vestibular schwannoma management: a prospective comparison of microsurgical resection and stereotactic radiosurgery. Neurosurgery. 2006 Jul;59(1):77-85; discussion 77-85. doi: 10.1227/01.NEU.0000219217.14930.14.
citation: Coelho DH, Roland JT Jr, Rush SA, Narayana A, St Clair E, Chung W, Golfinos JG. Small vestibular schwannomas with no hearing: comparison of functional outcomes in stereotactic radiosurgery and microsurgery. Laryngoscope. 2008 Nov;118(11):1909-16. doi: 10.1097/MLG.0b013e31818226cb.