Clinical trial NCT05855785: Effect of Dual Task Exercise on Cognitive and Physical Function in the Elderly With Mild Cognitive Impairment
Official title: Effect of Dual-task Exercise on Cognitive and Physical Function in the Elderly With Mild Cognitive Impairment: a Randomized Controlled Trial
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Cognitive Dysfunction
Mild Cognitive Impairment
Lead sponsor: Seoul National University Boramae Hospital
Sponsor class: OTHER
Collaborators: name: National Rehabilitation Center, Ministry of Health and Welfare, Korea
First posted: 2023-05-11
Enrollment: 12
Sex: ALL
Minimum age (years): 65
Standard ages: OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The purpose of this study is to investigate the effect of the dual task exercise program on cognitive and physical function in the elderly with mild cognitive impairment.

Detailed description: All participants provided written informed consent before study participation. A total of 12 community-dwelling participants were randomized either to the exercise group or to the control group.

The exercise group underwent 8-week, 3 times a week, 60-minute group exercise sessions, which were comprised of moderate-to-high intensity exercise and simultaneous cognitive tasks. They also performed moderate-intensity home aerobic exercises for at least 60 minutes per week. The control group performed 60-minute light intensity home exercise, 4 times a week for 8 weeks.

Eligibility criteria: Inclusion Criteria:

* a score on the Korean Montreal Cognitive Assessment (MoCA-K) of 25 points or below
* aged 65 or more
* no physical or medical problem which impairs moderate to vigorous physical activity

Exclusion Criteria:

* uncontrolled or unstable cardiovascular disease
* malignancy affecting general condition
* musculoskeletal problems affecting motor performance
* speech and hearing impairment
* other organic brain diseases

Primary outcomes:
measure: Dual task cost in Timed up and go (TUG)
timeFrame: Baseline
measure: Dual task cost in 10-meter walking test
timeFrame: Baseline
measure: Dual task cost in Timed up and go (TUG)
timeFrame: immediately after the 8-week intervention
measure: Dual task cost in 10-meter walking test
timeFrame: immediately after the 8-week intervention
Secondary outcomes:
measure: Korean Montreal Cognitive Assessment (MoCA-K)
timeFrame: Baseline
measure: Korean Montreal Cognitive Assessment (MoCA-K)
timeFrame: immediately after the 8-week intervention
measure: Korean Mini Mental Status Examination (K-MMSE)
timeFrame: Baseline
measure: Korean Mini Mental Status Examination (K-MMSE)
timeFrame: immediately after the 8-week intervention
measure: Computerized cognitive test(digit span test, visual learning test, verbal learning test, the Stroop Color and Word test, Boston naming test, trail making test, and verbal fluency test)
timeFrame: Baseline
measure: Computerized cognitive test(digit span test, visual learning test, verbal learning test, the Stroop Color and Word test, Boston naming test, trail making test, and verbal fluency test)
timeFrame: immediately after the 8-week intervention
measure: Short Physical Performance Battery (SPPB)
timeFrame: Baseline
measure: Short Physical Performance Battery (SPPB)
timeFrame: immediately after the 8-week intervention
measure: Berg Balance Scale (BBS)
timeFrame: Baseline
measure: Berg Balance Scale (BBS)
timeFrame: immediately after the 8-week intervention
measure: Falls Efficacy Scale (FES)
timeFrame: Baseline
measure: Falls Efficacy Scale (FES)
timeFrame: immediately after the 8-week intervention
measure: Activities-specific Balance Confidence (ABC)
timeFrame: Baseline
measure: Activities-specific Balance Confidence (ABC)
timeFrame: immediately after the 8-week intervention
measure: Grip strength
timeFrame: Baseline
measure: Grip strength
timeFrame: immediately after the 8-week intervention
measure: Korean version of Physical Activity Scale for the Elderly (K-PASE)
timeFrame: Baseline
measure: Korean version of Physical Activity Scale for the Elderly (K-PASE)
timeFrame: during intervention(8 weeks)
measure: International Physical Activity Questionnaires Short form (IPAQ)
timeFrame: Baseline
measure: International Physical Activity Questionnaires Short form (IPAQ)
timeFrame: during intervention (8 weeks)
measure: Metabolic Equivalent Task (MET) minutes per week
timeFrame: Baseline
measure: Metabolic Equivalent Task (MET) minutes per week
timeFrame: during intervention(8 weeks)
measure: Bioelectrical Impedance Analysis
timeFrame: Baseline
measure: Bioelectrical Impedance Analysis
timeFrame: immediately after the 8-week intervention
measure: Exercise Identity Scale (EIS)
timeFrame: Baseline
measure: Exercise Identity Scale (EIS)
timeFrame: immediately after the 8-week intervention
measure: Psychological Need Satisfaction in Exercise Scale (PNSE)
timeFrame: Baseline
measure: Psychological Need Satisfaction in Exercise Scale (PNSE)
timeFrame: immediately after the 8-week intervention
measure: Godin Leisure Time Exercise Questionnaire (GLTEQ)
timeFrame: Baseline
measure: Godin Leisure Time Exercise Questionnaire (GLTEQ)
timeFrame: immediately after the 8-week intervention
Other outcomes:
Locations:
city: Seoul
country: Korea, Republic of
facility: Seoul National University Boramae Medical Center
Study officials:
affiliation: Department of Rehabilitation Medicine, Seoul National University Boramae Medical Center
name: Se Hee Jung, MD, PhD
role: STUDY_CHAIR
References:
citation: Plummer P, Eskes G. Measuring treatment effects on dual-task performance: a framework for research and clinical practice. Front Hum Neurosci. 2015 Apr 28;9:225. doi: 10.3389/fnhum.2015.00225. eCollection 2015.