Clinical trial NCT04204148: To Explore the Related Factors of Cough After Thoracoscopic Pneumonectomy
Official title: Multivariate Analysis of Cough After Uniport Video-assisted Thoracoscopic Surgery Pneumonectomy
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Cough
Keywords: postoperative cough
Multivariate analysis
non-small cell lung cancer (NSCLC)
Uniport Video-assisted Thoracoscopic Surgery
Lead sponsor: The First Affiliated Hospital of Soochow University
Sponsor class: OTHER
First posted: 2019-12-18
Enrollment: 120
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Age ≥ 18 years old, male and female

Brief summary: To explore the related factors of cough after Uniport video-assisted thoracoscopic surgery pneumonectomy, and to provide theoretical basis and social accumulation of new knowledge for the diagnosis and treatment of cough after pneumonectomy in the future.

Detailed description: Intractable cough after thoracoscopic pneumonectomy is one of the common complications after pneumonectomy. The incidence of cough can reach 25% ≤ 50%. Cough after operation can aggravate the pain of incision, prolong the hospitalization time, increase the cost of hospitalization, affect the conversation and even sleep of the patients, increase the psychological burden of the patients, and reduce the quality of life of the patients accordingly. Therefore, through this study, the investigators hope to understand the related factors of cough after thoracoscopic pneumonectomy and whether there are predictable risk factors, so as to provide theoretical basis for reducing the occurrence of cough after pneumonectomy.

Eligibility criteria: Inclusion Criteria:

* Age ≥ 18 years old, male and female
* Uniport video-assisted thoracoscopic surgery
* No cough symptoms within two weeks before operation
* Informed consent form was signed before operation

Exclusion Criteria:

* Diabetes , heart, brain, liver and kidney diseases
* Chest radiographs / CT in recent months indicate pneumonia
* Pulmonary function cannot tolerate lobectomy / segmental / cuneiform resection
* Distant metastasis patients
* Before operation, there were internal causes of cough (including respiratory tract infectious diseases, pharyngitis, allergic rhinitis, posterior nasal drip syndrome, etc.)

Primary outcomes:
measure: The mean Leicester Cough Questionnaire in Mandarin Chinese (LCQ-MC) score before and after surgery
timeFrame: The day before surgery,two weeks after surgery,one month after surgery
Secondary outcomes:
measure: Hospitalization days
timeFrame: From the first days after surgery to discharge,up to 4 weeks
measure: Drainage
timeFrame: Measure the volume every 24 hours,up to 4 weeks
measure: Anesthesia time
timeFrame: Record total anesthesia during surgery
Other outcomes:
Locations:
city: Suzhou
country: China
facility: The First Affiliated Hospital of Soochow University
state: Jiangsu
Study officials:
affiliation: The First Affiliated Hospital of Soochow University
name: Liping Peng
role: PRINCIPAL_INVESTIGATOR
affiliation: The First Affiliated Hospital of Soochow University
name: Liuying Pan
role: PRINCIPAL_INVESTIGATOR
References:
citation: Dicpinigaitis PV, Rauf K. The influence of gender on cough reflex sensitivity. Chest. 1998 May;113(5):1319-21. doi: 10.1378/chest.113.5.1319.
citation: Birring SS, Spinou A. How best to measure cough clinically. Curr Opin Pharmacol. 2015 Jun;22:37-40. doi: 10.1016/j.coph.2015.03.003. Epub 2015 Mar 25.
citation: Harle ASM, Blackhall FH, Molassiotis A, Yorke J, Dockry R, Holt KJ, Yuill D, Baker K, Smith JA. Cough in Patients With Lung Cancer: A Longitudinal Observational Study of Characterization and Clinical Associations. Chest. 2019 Jan;155(1):103-113. doi: 10.1016/j.chest.2018.10.003. Epub 2018 Oct 13.
citation: Brignall K, Jayaraman B, Birring SS. Quality of life and psychosocial aspects of cough. Lung. 2008;186 Suppl 1:S55-8. doi: 10.1007/s00408-007-9034-x. Epub 2007 Oct 16.
citation: Xie MR, Zhu YF, Zhou MQ, Wu SB, Xu GW, Xu SB, Xu MQ. Analysis of factors related to chronic cough after lung cancer surgery. Thorac Cancer. 2019 Apr;10(4):898-903. doi: 10.1111/1759-7714.13021. Epub 2019 Mar 15.
citation: Koskela HO, Latti AM, Pekkanen J. The impacts of cough: a cross-sectional study in a Finnish adult employee population. ERJ Open Res. 2018 Nov 12;4(4):00113-2018. doi: 10.1183/23120541.00113-2018. eCollection 2018 Oct.
citation: Wang P, Zhu M, Zhang D, Guo XG, Zhao S, Zhang XL, Wang DL, Liu CT. The relationship between chronic obstructive pulmonary disease and non-small cell lung cancer in the elderly. Cancer Med. 2019 Aug;8(9):4124-4134. doi: 10.1002/cam4.2333. Epub 2019 Jun 11.
citation: Pan LY, Peng LP, Xu C, Ding C, Chen J, Wang WY, Zhu XY, Zhao J, Li C. Predictive factors of cough after uniportal video-assisted thoracoscopic pulmonary resection. J Thorac Dis. 2020 Oct;12(10):5958-5969. doi: 10.21037/jtd-20-2652.