louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT03345888: To Compare Predictive Power of End-tidal Carbon Dioxide Between Different Time Line During Resuscitation
Official title: To Compare Predictive Power of End-tidal Carbon Dioxide Between Different Time Line During Resuscitation
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Resuscitation
Lead sponsor: Peking Union Medical College Hospital
Sponsor class: OTHER
First posted: 2017-11-17
Enrollment: 130
Sex: ALL
Minimum age (years): 18
Maximum age (years): 100
Standard ages: ADULT
OLDER_ADULT
Observational model: COHORT
Time perspective: RETROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: CPR patient being treated in the emergency department

Brief summary: To analyze a multi-center observational study database. to select adult non-traumatic in-hospital cardiac arrest. Review and recored end-tidal carbon dioxide in per minute. Arrange them in different time line. one is in resuscitation time. The other is the time line which the beginning time is the time of starting appearing stable end-tidal carbon dioxide wave.To compare predictive power of end-tidal carbon dioxide between different time line during resuscitation.


Eligibility criteria: Inclusion Criteria:

adult non-traumatic in-hospital cardiac arrest patients Exclusion Criteria:1) surrogate decision of Do-Not-Resuscitate (DNR) during CPR; 2) out-of-hospital cardiac arrest (OHCA) patient; 3) trauma as the main reason for medical treatment; 4) child or adolescent patients; 5) Petco2 value was not recorded effectively; 6) delay from initial CPR to starting to record Petco2 exceeded 30 min; and 7) screening by qualified experts. More than three experienced physicians thought that the patient's Petco2 value was too extreme to agree with his/her medical history, and the value was seen as an error and was excluded

Primary outcomes:
measure: predictive power of ETCO2 is week at the beginning of resuscitation
timeFrame: 1 week
Secondary outcomes:
Other outcomes:
Locations:
city: Beijing
country: China
facility: Peking Union Medical College Hospital
Study officials:
References:
Clinical trial NCT04697888: Use of Omegaven for Treatment With Parenteral Nutrition Associated Liver Disease
Official title: Use of Omegaven for Treatment With Parenteral Nutrition Associated Liver Disease
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE2
PHASE3
Conditions: Parenteral Nutrition-related Hepatitis
Lead sponsor: Children's Mercy Hospital Kansas City
Sponsor class: OTHER
First posted: 2021-01-06
Enrollment: 2
Sex: ALL
Maximum age (years): 17
Standard ages: CHILD
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Intervention model description: This is a compassionate use protocol for patients with PNALD who have failed traditional treatment to receive Omegaven through an IND.
Primary purpose: TREATMENT

Brief summary: To provide parenteral fat emulsion prepared from fish oil (omega-3 fatty acid emulsion, Omegaven®) to patients with liver disease (PNALD).

Detailed description: This is a compassionate use protocol for patients with PNALD who have failed traditional treatment to receive Omegaven through an IND. Omegaven will be infused intravenously through either a central or peripheral catheter in conjunction with parenteral nutrition.

Eligibility criteria: Inclusion Criteria:

1. The patient will be PN dependent and unable to meet nutritional needs solely by enteral nutrition.
2. Patient will be \<18 years of age.
3. Direct bilirubin \> 2.0mg/dl
4. The patient must have failed standard therapies to prevent progression his/her liver disease.

Exclusion Criteria:

1. Other causes of chronic liver disease (Hepatitis C, Cystic fibrosis, biliary atresia, and alpha 1 anti-trypsin deficiency).
2. Patients who are allergic to eggs/shellfish
3. Patients who have severe hemorrhagic disorders.

Primary outcomes:
measure: Disease Progression as Measured by Serum Levels of Hepatic Enzymes
timeFrame: Up to 1 year
Secondary outcomes:
Other outcomes:
Locations:
city: Kansas City
country: United States
facility: Children's Mercy Hospitals and Clinics
state: Missouri
Study officials:
affiliation: Children's Mercy Hospital Kansas City
name: Joel D Lim, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT05245188: Evaluation of Cognitive Performance in 4 Dairy Beverages
Official title: Evaluation of Cognitive Performance in 4 Dairy Beverages
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Cognitive Performance
Lead sponsor: Universidad Católica San Antonio de Murcia
Sponsor class: OTHER
First posted: 2022-02-17
Enrollment: 20
Sex: ALL
Minimum age (years): 20
Maximum age (years): 35
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: OTHER

Brief summary: The objective of the study is to evaluate the cognitive performance of 4 chocolate milk drinks.

Detailed description: Subjects will make a total of 4 visits. Four visits in which they will drink a chocolate milkshake at each visit.

At each visit the subjects will have to come fasting, and they will have to perform the cognitive test at the time when they have their peak glycemic level.

Eligibility criteria: Inclusion Criteria:

* Subjects of both sexes (10 men and 10 women).
* Subjects aged between 20 and 35 years.
* Subjects with a body mass index between 20 and 25 kg/m2.

Exclusion Criteria:

* Subjects suffering from diabetes mellitus or any chronic disease.
* Subjects with medical problems or a diagnosed psychiatric disorder.
* Subjects with alcohol abuse or excessive alcohol consumption (\>3 glasses of wine or beer/day).
* Subjects consuming any pharmacological medication that may affect memory.
* Participation in another clinical trial in the three months prior to the study.
* Unwillingness or inability to comply with clinical trial procedures.
* Subjects whose condition does not make them eligible for the study according to the investigator's criteria.
* Pregnant or lactating women.

Primary outcomes:
measure: Cognitive performance
timeFrame: The test was carried out half an hour after consumption of the product, except for product 4, which was carried out 15 minutes after consumption.
Secondary outcomes:
measure: Depression, Anxiety and Stress
timeFrame: The test was carried out half an hour after consumption of the product, except for product 4, which was carried out 15 minutes after consumption.
measure: Sleep quality
timeFrame: The test was carried out half an hour after consumption of the product, except for product 4, which was carried out 15 minutes after consumption.
Other outcomes:
Locations:
city: Murcia
country: Spain
facility: Catholic University of Murcia
Study officials:
affiliation: Catholic University of Murcia
name: Fco Javier López Román
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT04527588: Italian Translation of the Michigan Hand Outcomes Questionnaire
Official title: Italian Translation and Cross-cultural Adaptation of the Michigan Hand Outcomes Questionnaire
Study type: OBSERVATIONAL
Overall status: WITHDRAWN
Conditions: Hand Fracture
Hand Osteoarthritis
Hand Injury Wrist
Hand Sprain
Wrist Injuries
Wrist Fracture
Wrist Arthritis
Lead sponsor: University of Zurich
Sponsor class: OTHER
First posted: 2020-08-26
Enrollment: 0
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: CASE_CONTROL
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Native Italian speaking patients followed by the Hand Therapy of the University Hospital Zürich and the Handtherapy Fairplay center of Bologna, IT, with a pathology of the hand/s and or wrist/s.

Brief summary: Patient-Reported Outcome Measures (PROMs) are important clinical items for evaluating injuries and recovery of the hand. Some of the most used Questionnaires, unfortunately, are not available in Italian.

Detailed description: Patient-Reported Outcome Measures (PROMs) are important clinical items for evaluating injuries and recovery of the hand. Some of the most used Questionnaires, unfortunately, are not available in Italian. This poses a problem when evaluating Italian speaking patients. Our aim is to develop a culturally adapted Italian version of the Michigan Hand Questionnaire. There is no risk involved for the patients, as the task of the recruited patients is to answer a survey (online and in clinics).

Eligibility criteria: Inclusion Criteria:

* age \> 18 years
* native Italian speakers
* wrist/hand pathology
* trauma (fractures, tendon injuries, etc.)
* chronic pathology, the pathology has been present for at least 1 month (tenosynovitis, chronic arthrosis pain, rheumatic hand or wrist disorders)
* in case of hand/wrist surgery: at least 4 weeks have elapsed since surgery to avoid that the patient could not perform certain actions evaluated by the scale, for example lifting a pan or shopping bags, due to normal post-operative precautions.
* full possession of mental capacity

Exclusion Criteria:

* age \< 18 years
* non-native Italian speakers of Italian, thus also excluding second generation Swiss Italians ("secundo")
* mental incapacity
* upper limb in cast/locked by splint (criterion in Chung's article 98) at the time of the evaluation

Primary outcomes:
measure: Validity
timeFrame: 3 months
Secondary outcomes:
measure: Reliability
timeFrame: 3 months
Other outcomes:
Locations:
Study officials:
affiliation: University Hospital, Zürich
name: Maurizio Calcagni, MD
role: STUDY_DIRECTOR
References:
Clinical trial NCT02529488: Investigation of AcrySof® IQ PanOptix™ Presbyopia-Correcting Intraocular Lens (IOL) Model TFNT00
Official title: Investigation of AcrySof® IQ PanOptix™ Presbyopia-Correcting IOL Model TFNT00
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Cataract
Lead sponsor: Alcon Research
Sponsor class: INDUSTRY
First posted: 2015-08-20
Enrollment: 167
Sex: ALL
Minimum age (years): 22
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: TREATMENT

Brief summary: The purpose of this study is to investigate visual outcomes and assess safety at 12 months (330-420 days) post bilateral implantation of the AcrySof® IQ PanOptix™ Presbyopia-Correcting IOL.

Detailed description: This study will be conducted in regions where the test article is approved at the time of study start.

Eligibility criteria: Inclusion Criteria:

* Diagnosis of bilateral cataracts with planned cataract removal by phacoemulsification with a clear cornea incision;
* Able to comprehend and willing to sign informed consent and complete all required postoperative follow-up procedures;
* Clear intraocular media other than cataract in both eyes;
* Other protocol-specified inclusion criteria may apply.

Exclusion Criteria:

* Clinically significant corneal abnormalities including corneal dystrophy, inflammation or edema;
* Ocular trauma, corneal transplant, retinal conditions, degenerative eye disorders, or color vision deficiencies;
* Glaucoma (uncontrolled or controlled with medication) or ocular hypertension;
* Pregnant or lactating;
* Expected to require ocular surgical or retinal laser treatment;
* Other protocol-specified exclusion criteria may apply.

Primary outcomes:
measure: Mean Binocular Defocus Visual Acuity (VA)
timeFrame: Day 20-40 and Day 120-180 from second eye implantation
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
affiliation: Alcon Research
name: Sr Clinical Manager, Cataract
role: STUDY_DIRECTOR
References:
Clinical trial NCT05993988: The Effect of Telerehabilitation on Clinical Stress Level and Stress Responses in Nursing Students
Official title: The Effect of Telerehabilitation Practice on the Clinical Stress Level and Stress Responses of Nursing Students During Their First Clinical Experience
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Stress
Lead sponsor: KTO Karatay University
Sponsor class: OTHER
First posted: 2023-08-16
Enrollment: 75
Sex: ALL
Minimum age (years): 18
Maximum age (years): 24
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Intervention model description: parallel assignment
Primary purpose: TREATMENT

Brief summary: It was aimed to examine the effect of telerehabilitation on clinical stress level and stress responses in nursing students.

Detailed description: It was aimed to examine the effect of telerehabilitation on clinical stress level and stress responses in nursing students.There is no study in the literature examining the relationship between telerehabilitation and clinical stress in nursing students. Since our study will be the first to investigate the subject, we foresee that it is scientifically important and will shed light on future studies. In addition, national or international publications are planned after the study is completed.

Eligibility criteria: Inclusion Criteria:

* to be between the ages of 18-24
* to do the first clinical internship in the hospital

Exclusion Criteria:

* have joint limitation
* have congenital anomaly
* have any orthopedic problem
* have any serious psychological problems

Primary outcomes:
measure: Perceived Stress Scale for Nursing Students
timeFrame: baseline and 4 weeks
measure: Biopsychosocial Response Scale of Nursing Students
timeFrame: baseline and 4 weeks
Secondary outcomes:
Other outcomes:
Locations:
city: Karatay
country: Turkey
facility: Mustafa Savaş Torlak
state: Eyalet/Yerleşke
Study officials:
References:
Clinical trial NCT00190788: Extended Therapy of Drotrecogin Alfa (Activated) 4 vs 7 Days Infusion
Official title: A Phase IIIb Study to Determine Efficacy and Safety of Extended Drotrecogin Alfa (Activated) Therapy in Patients With Persistent Requirement for Vasopressor Support After 96 Hour Infusion With Commercial Drotrecogin Alfa (Activated)
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE3
Conditions: Sepsis
Hypotension
Lead sponsor: Eli Lilly and Company
Sponsor class: INDUSTRY
First posted: 2005-09-19
Enrollment: 200
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The purpose of this study is to determine whether continued administration of Drotrecogin Alfa (Activated) up to additional 72 hours - after the so far recommended 96 hour infusion period - results in a more rapid resolution of hypotension in severe septic patients.


Eligibility criteria: Inclusion Criteria:

* Severe sepsis patients treated with 96 hour infusion of commercial Drotrecogin Alfa (Activated)
* Continue requirement of Vasopressor support after 96 hour commercial infusion

Exclusion Criteria:

* Patients require extensive surgical procedures within next 3 days
* Patients with platelet count below 30,000/mm3
* Patients receiving therapeutic heparin of 15,000 units/day and more
* Patients not expected to survive 24 days
* Patients contraindicated as to the country specific registration

Primary outcomes:
measure: - To assess whether continued administration of Drotrecogin Alfa (Activated)for up to 72 additional hours after 96 hours infusion of commercial DDA results in more rapid resolution of vasopressor-dependent hypotension
Secondary outcomes:
measure: Evaluate Reduction of 28-day all cause mortality
measure: Evaluate effects on various organ functions over 14 days
measure: Evaluate effects on the concentration of various biomarkers
measure: Investigate safety profile of an extended infusion of DDA
Other outcomes:
Locations:
city: Loma Linda
country: United States
facility: For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.
state: California
city: Paris
country: France
facility: For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.
Study officials:
affiliation: Eli Lilly and Company
name: Call 1-877-CTLILLY (1-877-285-4559) or 1-317-615-4559 Mon-Fri 9AM - 5 PM Eastern time (UTC/GMT - 5 hours, EST)
role: STUDY_DIRECTOR
References:
Clinical trial NCT04986488: INCIDENCE OF Delirium After Cardiac SURGERY Surgery
Official title: Incidence And Predictors of Delirium After Cardiac Surgery; A Prospective Observational Cohort Study From a Single Tertiary Referral Centre
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Delirium
Keywords: delirium;post-cardiac surgery;adults
Lead sponsor: Shahid Gangalal National Heart Centre
Sponsor class: OTHER
First posted: 2021-08-02
Enrollment: 234
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Patients 18 years old and older of both sexes who are undergoing cardiac surgery in a single centre

Brief summary: Delirium is a common problem that occurs after cardiac surgery. The incidence of delirium after cardiac surgery is estimated to be 26-52%, with a significant percentage being hypoactive delirium1-4.Postoperative delirium has been associated with higher hospital costs, longer lengths of hospital stay, increased likelihood of institutionalization, increased risk for dementia, and increased morbidity and mortality.5-7 .

The overall purpose of this study was to determine the incidence and perioperative factors that predispose to cause delirium in postoperative cardiac surgery patients in our ICU


Eligibility criteria: Inclusion Criteria:

* Patients 18 years old and older of both sexes
* Patients who signed an informed consent
* Patients scheduled for cardiac surgery with extracorporeal circulation (coronary-artery bypass grafting (CABG), cardiac valve replacement (CVR), combined CABG + CVR, excision of cardiac myxoma)

Exclusion Criteria:

* Patients who refused to participate before or after operation;
* Patients in poor general condition;
* Patients with preoperative dementia, delirium or illiterate, psychiatric or mental disorder (epilepsy, schizophrenia, depression);
* Patients who died intraoperatively or within the first 6 hours after the procedure.

Primary outcomes:
measure: incidence and perioperative factors that predispose to cause delirium in postoperative cardiac surgery patients in our ICU
timeFrame: 6 months
Secondary outcomes:
measure: ICU stay and mechanical ventilation time
timeFrame: 6 months
Other outcomes:
Locations:
city: Kathmandu
country: Nepal
facility: Shahid Gangalal National Heart Center
Study officials:
References:
Clinical trial NCT06945588: The Influence of Different Music Genres on Hearing Performance in Noise
Official title: The Influence of Different Music Genres on Hearing Performance in Noise
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Hearing
Lead sponsor: Istanbul Aydın University
Sponsor class: OTHER
First posted: 2025-04-25
Enrollment: 63
Sex: ALL
Minimum age (years): 18
Maximum age (years): 35
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: CROSSOVER
Primary purpose: OTHER

Brief summary: A fast tempo and major mode music improves cognitive performance by triggering a feeling of happiness. This study examines the impact of music on hearing performance, hypothesizing that listening to happy music may improve hearing performance in noise. Sixty-three normal hearing subjects aged between 18 and 35 years old were included. The subjects were randomly assigned to three groups: happy music, sad music, and control groups. The songs composed in minor mode with a tempo of \<80 beats per minute were categorized as "sad," while songs composed in major mode with a tempo of \>120 beats per minute were categorized as "happy". The Audible Contrast Threshold (ACT) Test and Hearing in Noise Test (HINT) were administered before and immediately after playing the music tracks. Repeated measures ANOVA test was run to compare the changes in measurement scores before and after listening to music.


Eligibility criteria: Inclusion Criteria:

* Native Turkish speakers,
* Aged between 18 and 35 years old with normal hearing thresholds (pure tone average \<25 dB),
* No history of otologic, psychiatric, or neurologic diseases

Exclusion Criteria:

-

Primary outcomes:
measure: The change in hearing performance in noise will be examined with Turkish Hearing in Noise Test after listening to different music genres.
timeFrame: Before and immediately after playing the music tracks.
Secondary outcomes:
measure: The change in hearing performance in noise will be examined with Audible Contrast Thresholdafter listening to different music genres.
timeFrame: Before and immediately after playing the music tracks.
Other outcomes:
Locations:
city: Istanbul
country: Turkey
facility: Istanbul Aydin University
Study officials:
References:
Clinical trial NCT01709188: Musical Dual Task Training to Improve Attention Control for Dementia
Official title: The Effects of Musical Dual Task Training on Attention Control and Associated Gait Stability of Patients With Mild to Moderate Dementia
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Dementia
Keywords: Musical Dual Task Training
dementia
attention control
dual task cost
gait stability
Lead sponsor: Chang Gung Memorial Hospital
Sponsor class: OTHER
First posted: 2012-10-18
Enrollment: 30
Sex: ALL
Minimum age (years): 55
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The purpose of this project is to determine if the Musical Dual Task Training program improves attention control that influences measures of gait performances under dual tasking, balance, fear of falling, and behavioral disturbance in patients with mild to moderate dementia. This Musical Dual Task Training protocol is structured with musical content and patients are required to do musical tasks including singing and playing instruments contingent on visual or auditory cues while walking. This paradigm is designed to include music making because it involves great demands on attention and memory that might elicit experience-dependent plasticity in the brain. Musical Dual Task Training is proposed to strengthen brain networking for attention control that consequently may improve the gait performances in patients with dementia, as indicated by reducing dual task cost on gait.


Eligibility criteria: Inclusion Criteria:

* a mild to moderate dementia diagnosis with Clinical Dementia Rating (CDR) score: .5, 1, or 2
* ability to walk 10 meters independently without the use of a walker or cane, or the assistance by another person

Exclusion Criteria:

* other known neurologic disorders such as stroke or Parkinson's disease
* significant orthopedic, visual, and hearing impairment that hinders ambulation

Primary outcomes:
measure: Change from Baseline on the Trail Making Test at 2 months
timeFrame: Baseline and at 2 months
Secondary outcomes:
measure: Change from Baseline on Walking Speed during Dual tasking at 2 Months
timeFrame: Baseline and at 2 months
measure: Change from Baseline on the Timed Up-and-Go test at 2 Months
timeFrame: Baseline and 2 months
measure: Change from Baseline on the 7-item Short Falls Efficacy Scale International at 2 Months
timeFrame: Baseline and at 2 months
measure: Change from Baseline on the Cohen-Mansfield Agitation Inventory scale at 2 months
timeFrame: Baseline and at 2 months
measure: Change from Baseline on Stride Lengths during Dual Tasking at 2 Months
timeFrame: Baseline and at 2 months
Other outcomes:
Locations:
city: Taoyuan
country: Taiwan
facility: Chang Gung Medical Foundation
Study officials:
affiliation: Chang Gung Medical Foundation
name: Yu-Cheng Pei, MD, PhD
role: PRINCIPAL_INVESTIGATOR
References: