Clinical trial NCT00440960: Anesthesia in Flexible Bronchoscopy for Lung Cancer Diagnostic
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE4
Conditions: Lung Cancer
Keywords: alfentanil
anesthesia
bronchoscopy
lidocaine
midazolam
propofol.
Lead sponsor: Hospital Pompeia
Sponsor class: OTHER
First posted: 2007-02-27
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Allocation: RANDOMIZED
Intervention model: FACTORIAL
Primary purpose: TREATMENT

Brief summary: The objective of the study was to establish which anesthetic procedure used during flexible bronchoscopy has the lowest index of complications.

Detailed description: This prospective randomized study analyzed 80 patients that underwent flexible bronchoscopy. Patients were randomly assigned to four groups of 20 patients each according to the anesthetic combination used: 200 mg topical lidocaine (LID group); 200 mg topical lidocaine and 2 mg/kg propofol (PPF group); 200 mg topical lidocaine and 20 mcg/kg alfentanil (ALF group); or 200 mg topical lidocaine and 0.05 mg/kg midazolam (MID group). Scores were assigned to patients according to the different variables observed during the endoscopic procedure; the lower the score, the lower the complication index.

Eligibility criteria: Inclusion Criteria:

* The patients included in this study were referred to FBC for the investigation of bronchial carcinoma (diagnostic procedure).
* Patients included in the study were classified as ASA I, II and II according to the anesthetic risk classification of the American Society of Anesthesiologists (ASA).

Exclusion Criteria:

* ASA IV classification of anesthesiology risk
* procedure that lasted longer than 15 minutes
* indication of therapeutic bronchoscopy
* cardiac arrhythmia and / or hypoxemia detected at admission.

Primary outcomes:
Secondary outcomes:
Other outcomes:
Locations:
city: Caxias do Sul
country: Brazil
facility: Hospital Pompeia
state: RS
city: Caxias do Sul
country: Brazil
facility: Hospital Medianeira
state: RS
city: Caxias do Sul
country: Brazil
facility: General Hospital of Universidade de Caxias do Sul
state: RS
Study officials:
affiliation: Brazilian Society of Thoracic Surgery
name: Andre GS Leite, PhD
role: PRINCIPAL_INVESTIGATOR
References:
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