Clinical trial NCT04698356: Speech Perception With High Cognitive Demand
Official title: Pilot Study - Validation of Speech Materials for an Auditory-cognitive Training Paradigm (NIH P01 Project - Speech Perception With High Cognitive Demand)
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Speech Intelligibility
Aging
Keywords: Auditory-cognitive training
Aging
Speech-in-noise perception
Lead sponsor: University of Maryland, College Park
Sponsor class: OTHER
Collaborators: name: National Institute on Aging (NIA)
First posted: 2021-01-06
Enrollment: 15
Sex: ALL
Minimum age (years): 18
Maximum age (years): 30
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: TREATMENT

Brief summary: With advancing age, adults experience increasing speech understanding difficulties in challenging situations. Currently, speech-in-noise difficulties are rehabilitated by providing hearing aids. For older normal-hearing adults, however, hearing devices do not provide much benefit since these adults do not have a decreased hearing sensitivity. The goal of the "Speech Perception with High Cognitive Demand" Project is to evaluate the benefit of a new auditory-cognitive training paradigm. In order to provide maximal benefit for older, normal-hearing adults, a validation of the new training materials is required. In a pilot study, the investigators will evaluate the new auditory-cognitive training paradigm in 15 young, normal-hearing adults (18-30 years). Based on these results, the training paradigm can be further optimized for older adults.

Detailed description: With advancing age, adults experience increasing speech understanding difficulties in challenging situations, such as difficulty with understanding other persons in a noisy restaurant. Speech-in-noise difficulties are typically rehabilitated by providing hearing aids. For older normal-hearing adults, however, hearing devices do not provide much benefit since these adults do not have a decreased hearing sensitivity. For these adults communication difficulties persist in everyday life situations and can even lead to social withdrawal, isolation, and depression.

A growing body of studies demonstrates that combined auditory-cognitive training paradigms can offer speech-in-noise benefits to adults with hearing loss that could prevent the consequences listed above (Ferguson \& Henshaw, 2015; Lawrence et al., 2018). The goal of the "Speech Perception with High Cognitive Demand" Project is to evaluate the benefit of a new auditory-cognitive training paradigm for older normal-hearing adults. The investigators developed an American English version of the Nottingham (UK) PLUS training paradigm in which listeners are asked to focus and listen to one speaker while ignoring another speaker. Although it cannot ensured that every participant will experience direct significant benefit from the training, the paradigm is being designed to optimally enhance the possibility of benefit: an adaptive procedure is employed in order to train each individual at their own level and to make the task challenging, and a short-term memory component is added to the original training paradigm to also enhance the cognitive skills of the participants. In addition, the training is implemented on tablets rather than computers, making at-home training possible (many older adults are more comfortable with tablets than laptops). This way, not only the risk of COVID-19 for participants is minimized, but training is also provided in a realistic setting which will ensure a better transfer of the trained skills to daily communication situations.

In order to provide maximal benefit for older, normal-hearing adults, a validation of the new training materials is however required, and the initial validation will be for younger adults only. The investigators will evaluate the translated and adjusted sentences (from UK to American English), the adaptive procedure, and the short-term memory component, in young, normal-hearing adults (18-30 years). Based on the results of this pilot study, the sentences and procedures of the training paradigm can be further optimized for older adults.

Eligibility criteria: Inclusion Criteria:

* Age between 18-30 years
* Normal hearing (pure-tone thresholds \<= 25 dB HL from 250-8000 Hz)
* Dominant language: American English
* Education: a high school diploma or higher educational level

Exclusion Criteria:

* Middle-ear or inner ear pathology
* Non-native speaker of English
* Inability to complete all training sessions within a pre-specified time window (e.g., due to unexpected schedule restrictions)
* Learning disorders.

Primary outcomes:
measure: Speech reception threshold (SRT)
timeFrame: Through study completion, an average of 2 months
Secondary outcomes:
Other outcomes:
Locations:
city: College Park
country: United States
facility: Department of Hearing and Speech Sciences
state: Maryland
Study officials:
affiliation: University of Maryland, College Park
name: Samira B Anderson, PhD
role: PRINCIPAL_INVESTIGATOR
affiliation: University of Maryland, College Park
name: Jonathan Z Simon, PhD
role: PRINCIPAL_INVESTIGATOR
affiliation: Walter Reed National Military Medical Center
name: Stefanie E Kuchinsky, PhD
role: PRINCIPAL_INVESTIGATOR
References: