Clinical trial NCT06497556: A Study Evaluating the Efficacy and Safety of Divarasib Versus Sotorasib or Adagrasib in Participants With Previously Treated KRAS G12C-positive Advanced or Metastatic Non-Small Cell Lung Cancer
Official title: A Phase III, Randomized, Open-Label, Multicenter Study Evaluating the Efficacy and Safety of Divarasib Versus Sotorasib or Adagrasib in Patients With Previously Treated KRAS G12C-Positive Advanced or Metastatic Non-Small Cell Lung Cancer
Study type: INTERVENTIONAL
Overall status: RECRUITING
Phase: PHASE3
Conditions: Non-Small Cell Lung Cancer
KRAS G12C Lung Cancer
Keywords: Advanced Non-Small Cell Lung Cancer
KRAS G12 Lung Cancer
Advanced Lung Cancer
Metastatic lung cancer
Divarasib
KRAS G12C Inhibitor
KRAS G12C Positive
KRAS Mutation
KRAS G12C Mutation
Lung Cancer Mutation
Lead sponsor: Hoffmann-La Roche
Sponsor class: INDUSTRY
Collaborators: name: Chugai Pharmaceutical
First posted: 2024-07-11
Enrollment: 320
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The purpose of this study is to assess the safety and efficacy of divarasib compared to locally approved KRAS G12C inhibitors (sotorasib or adagrasib) in participants with KRAS G12C-positive (KRAS G12C +) advanced or metastatic non-small cell lung cancer (NSCLC).


Eligibility criteria: Inclusion Criteria:

* Unequivocal histologically or cytologically confirmed diagnosis of metastatic or locally advanced NSCLC not amenable to treatment with surgical resection or combined chemoradiation
* Disease progression during or after treatment with at least one prior systemic therapy but no more than three lines of prior systemic therapy in the advanced or metastatic setting
* Measurable disease according to Response Evaluation Criteria in Solid Tumors (RECIST) v1.1
* Documentation of the presence of a KRAS G12C mutation
* Availability of a representative formalin-fixed, paraffin-embedded (FFPE) tumor specimen in a paraffin block (preferred) or 10-15 (15 preferred) unstained, freshly cut, serial slides with an associated pathology report
* Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1
* Life expectancy of \>= 12 weeks

Exclusion Criteria:

* Known hypersensitivity to any of the components of divarasib, or sotorasib or adagrasib
* Malabsorption syndrome or other condition that would interfere with enteral absorption
* Known concomitant second oncogenic driver
* Mixed small-cell lung cancer or large cell neuroendocrine histology
* Known and untreated, or active central nervous system (CNS) metastases
* Leptomeningeal disease or carcinomatous meningitis
* Uncontrolled pleural effusion, pericardial effusion, or ascites requiring recurrent drainage procedures biweekly or more frequently
* Any infection that, in the opinion of the investigator, could impact patient safety, or treatment with therapeutic oral or IV antibiotics within 14 days prior to Day 1 of Cycle 1
* Prior treatment with any KRAS G12C inhibitor or pan-KRAS/RAS inhibitor
* More than 30 Gy of radiotherapy to the lung within 6 months of randomization
* Uncontrolled tumor-related pain
* Unresolved toxicities from prior anticancer therapy
* History of malignancy within 5 years prior to screening, with the exception of the cancer under investigation in this study and malignancies with a negligible risk of metastasis or death (e.g., 5-year OS rate \>90%), such as adequately treated carcinoma in situ of the cervix, nonmelanoma skin carcinoma, localized prostate cancer, ductal carcinoma in situ, or Stage I uterine cancer

Primary outcomes:
measure: Progression-Free Survival (PFS)
timeFrame: Up to approximately 4 years
Secondary outcomes:
measure: Overall Survival (OS)
timeFrame: Up to approximately 4 years
measure: Objective Response
timeFrame: Up to approximately 4 years
measure: Time to Confirmed Deterioration (TTCD) on the European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire (EORTC QLQ-C30) Dyspnea Item and Physical Functioning Scale
timeFrame: Baseline up to approximately 4 years
measure: TTCD on the EORTC Quality-of-Life Questionnaire-Supplemental Lung Cancer Module (QLQ-LC13) Cough Scale
timeFrame: Baseline up to approximately 4 years
measure: Duration of Response (DOR)
timeFrame: Up to approximately 4 years
measure: Percentage of Participants with Adverse Events (AEs)
timeFrame: Up to approximately 4 years
measure: Number of Participants Reporting Presence, Frequency, Severity, and/or Degree of Interference with Daily Function of Symptomatic Treatment Toxicities Assessed by NCI Patient-Reported Outcomes Common Terminology Criteria for Adverse Events (PRO-CTCAE)
timeFrame: Up to approximately 4 years
measure: Change from Baseline in Diarrhea, Nausea, Vomiting, Anorexia, Alopecia, Dyspnea, Cough, Constipation, Myalgia, Headache, and Rash/Acne as Assessed Through use of the NCI PRO-CTCAE
timeFrame: Baseline up to approximately 4 years
measure: Frequency of Participants' Response of the Degree they are Troubled with Treatment Symptoms, as Assessed Through use of the single-item EORTC Item List (IL46)
timeFrame: Up to approximately 4 years
measure: Change from Baseline in Cough, Chest Pain, Dyspnea, Physical and Role Functioning, and Global Health Status score/Quality of Life Score (GHS/QoL) at Each Timepoint as Assessed Through use of the EORTC QLQ-LC13 and QLQ-C30
timeFrame: Baseline up to approximately 4 years
measure: TTCD on the EORTC QLQ-C30 Role Functioning and GHS/QoL scales
timeFrame: Up to approximately 4 years
measure: TTCD on the Chest Pain Scale of the QLQ-LC13 Scales
timeFrame: Up to approximately 4 years
Other outcomes:
Locations:
city: Gilbert
country: United States
facility: Banner Health MD Anderson AZ
state: Arizona
city: Little Rock
country: United States
facility: University of Arkansas For Medical Sciences
state: Arkansas
city: Los Angeles
country: United States
facility: Los Angeles Cancer Network
state: California
city: Los Angeles
country: United States
facility: UCLA Hematology / Oncology Clinic
state: California
city: Orange
country: United States
facility: Community Clinical Trials
state: California
city: San Francisco
country: United States
facility: Zuckerberg San Francisco General Hospital
state: California
city: San Francisco
country: United States
facility: University of California, San Francisco
state: California
city: Colorado Springs
country: United States
facility: UC Health Oncology Research
state: Colorado
city: New Haven
country: United States
facility: Yale Cancer Center
state: Connecticut
city: Bay Pines
country: United States
facility: Bay Pines Foundation Inc
state: Florida
city: Fort Myers
country: United States
facility: Florida Cancer Specialists
state: Florida
city: Miami
country: United States
facility: University of Miami
state: Florida
city: Saint Augustine
country: United States
facility: Cancer Specialists of North Florida
state: Florida
city: Saint Petersburg
country: United States
facility: Florida Cancer Specialists.
state: Florida
city: West Palm Beach
country: United States
facility: Florida Cancer Specialists
state: Florida
city: Athens
country: United States
facility: University Cancer & Blood Center, LLC
state: Georgia
city: Savannah
country: United States
facility: Summit Cancer Care PC
state: Georgia
city: Chicago
country: United States
facility: University of Chicago Medical Center
state: Illinois
city: Muncie
country: United States
facility: IU Health Ball Memorial Hospital
state: Indiana
city: Waukee
country: United States
facility: Mission Cancer + Blood - IMMC
state: Iowa
city: Lexington
country: United States
facility: Baptist Health Lexington
state: Kentucky
city: Louisville
country: United States
facility: Norton Cancer Institute- Poplar
state: Kentucky
city: Shreveport
country: United States
facility: VA Shreveport Healthcare System
state: Louisiana
city: Scarborough
country: United States
facility: New England Cancer Specialists
state: Maine
city: Boston
country: United States
facility: Beth Israel Deaconess Medical Center
state: Massachusetts
city: Boston
country: United States
facility: Dana Farber Cancer Institute
state: Massachusetts
city: Foxboro
country: United States
facility: Dana Farber/Harvard Cancer Center (Foxborough)
state: Massachusetts
city: Methuen
country: United States
facility: Dana-Farber Cancer Institute
state: Massachusetts
city: Ann Arbor
country: United States
facility: University of Michigan
state: Michigan
city: Detroit
country: United States
facility: Henry Ford Health System;Clinical Trials Office
state: Michigan
city: Grand Rapids
country: United States
facility: Cancer and Hematology Centers of Western Michigan
state: Michigan
city: Omaha
country: United States
facility: Nebraska Methodist Estabrook Cancer Center
state: Nebraska
city: Reno
country: United States
facility: Renown Regional Medical Center Hospital
state: Nevada
city: Bronx
country: United States
facility: New York Cancer & Blood Specialists
state: New York
city: New Hyde Park
country: United States
facility: New York Cancer & Blood Specialists - New Hyde Park
state: New York
city: New York
country: United States
facility: New York Cancer and Blood Specialists-Central Park Hematology & Oncology
state: New York
city: New York
country: United States
facility: Mount SInai Medical Center
state: New York
city: New York
country: United States
facility: Columbia University Medical Center
state: New York
city: Shirley
country: United States
facility: North Shore Hematology Oncology Associates P.C. DBA New York Cancer and Blood Specialists
state: New York
city: Chapel Hill
country: United States
facility: University of North Carolina At Chapel Hill
state: North Carolina
city: Greenville
country: United States
facility: East Carolina University
state: North Carolina
city: Pinehurst
country: United States
facility: Firsthealth of The Carolinas
state: North Carolina
city: Columbus
country: United States
facility: Ohio State University Comprehensive Cancer Center
state: Ohio
city: Columbus
country: United States
facility: SCRI Mark H. Zangmeister Center
state: Ohio
city: Maumee
country: United States
facility: Taylor Cancer Research Center
state: Ohio
city: Eugene
country: United States
facility: Oncology Associates of Oregon, P.C
state: Oregon
city: Portland
country: United States
facility: Oregon Health & Science University
state: Oregon
city: Pittsburgh
country: United States
facility: Allegheny Cancer Center
state: Pennsylvania
city: Spartanburg
country: United States
facility: Gibbs Cancer Center & Research Institute
state: South Carolina
city: Sioux Falls
country: United States
facility: Avera Cancer Institute
state: South Dakota
city: Chattanooga
country: United States
facility: Tennessee Oncology, PLLC - Chattanooga
state: Tennessee
city: Memphis
country: United States
facility: Baptist Clinical Research Institute
state: Tennessee
city: Nashville
country: United States
facility: Tennessee Oncology
state: Tennessee
city: Fort Worth
country: United States
facility: JPS Health Network
state: Texas
city: Houston
country: United States
facility: MD Anderson Cancer Center
state: Texas
city: Longview
country: United States
facility: Texas Oncology - Northeast Texas
state: Texas
city: Richmond
country: United States
facility: Virginia Commonwealth University - Massey Cancer Center
state: Virginia
city: Buenos Aires
country: Argentina
facility: Hospital Britanico
city: Ciudad Autonoma Buenos Aires
country: Argentina
facility: Centro Oncologico Korben
city: Ciudad Autonoma Buenos Aires
country: Argentina
facility: Clinica Adventista Belgrano
city: Rosario
country: Argentina
facility: Sanatorio Parque S.A.
city: Darlinghurst
country: Australia
facility: Kinghorn Cancer Centre
state: New South Wales
city: Liverpool
country: Australia
facility: Liverpool Hospital
state: New South Wales
city: St Leonards
country: Australia
facility: GenesisCare North Shore
state: New South Wales
city: Birtinya
country: Australia
facility: Sunshine Coast University Hospital
state: Queensland
city: Elizabeth Vale
country: Australia
facility: Lyell McEwin Hospital
state: South Australia
city: Melbourne
country: Australia
facility: Peter Maccallum Cancer Centre
state: Victoria
city: Wien
country: Austria
facility: Klinik Penzing
city: Wien
country: Austria
facility: Institut für Lungenforschung Wien
city: Wien
country: Austria
facility: Krankenhaus Nord - Klinik Floridsdorf
city: Aalst
country: Belgium
facility: AZORG Campus Aalst-Moorselbaan
city: Brussel
country: Belgium
facility: UZ Brussel
city: Bruxelles
country: Belgium
facility: Cliniques Universitaires St-Luc
city: Edegem
country: Belgium
facility: UZ Antwerpen
city: Hasselt
country: Belgium
facility: Jessa Zkh (Campus Virga Jesse)
city: Liège
country: Belgium
facility: CHU Sart-Tilman
city: Mont-godinne
country: Belgium
facility: CHU UCL Mont-Godinne
city: Roeselare
country: Belgium
facility: AZ Delta (Campus Rumbeke)
city: Sint Niklaas
country: Belgium
facility: Vitaz
city: Wilrijk
country: Belgium
facility: Sint Augustinus Wilrijk
city: Salvador
country: Brazil
facility: Hospital Sao Rafael - HSR
state: Bahia
city: Brasilia
country: Brazil
facility: Hospital Brasilia
state: Distrito Federal
city: Campo Grande
country: Brazil
facility: Clinica Onconeo
state: Mato Grosso Do Sul
city: Porto Alegre
country: Brazil
facility: Santa Casa de Misericordia de Porto Alegre
state: Rio Grande Do Sul
city: Porto Alegre
country: Brazil
facility: Hospital Nossa Senhora da Conceicao
state: Rio Grande Do Sul
city: Porto Alegre
country: Brazil
facility: Hospital Mae de Deus
state: Rio Grande Do Sul
city: Barretos
country: Brazil
facility: Hospital de Cancer de Barretos
state: São Paulo
city: Sao Jose do Rio Preto
country: Brazil
facility: Hospital de Base de Sao Jose do Rio Preto
state: São Paulo
city: Sao Paulo
country: Brazil
facility: Hospital Sírio-Libanês
state: São Paulo
city: Sao Paulo
country: Brazil
facility: Hospital Alemao Oswaldo Cruz
state: São Paulo
city: Rio de Janeiro
country: Brazil
facility: Oncoclinicas Rio de Janeiro S.A.
city: Brampton
country: Canada
facility: William Osler Health Centre - Brampton Civic Hospital
state: Ontario
city: Toronto
country: Canada
facility: Princess Margaret Cancer Center
state: Ontario
city: Montreal
country: Canada
facility: Jewish General Hospital
state: Quebec
city: Aarhus N
country: Denmark
facility: Aarhus Universitetshospital
city: Herlev
country: Denmark
facility: Herlev Hospital
city: Herning
country: Denmark
facility: Regionshospitalet Gødstrup
city: Helsinki
country: Finland
facility: Helsinki University Central Hospital
city: Kuopio
country: Finland
facility: Kuopio Uni Hospital
city: Turku
country: Finland
facility: Turku Uni Central Hospital
city: Angers
country: France
facility: CHU Angers
city: Brest
country: France
facility: CHRU Brest
city: Bron
country: France
facility: Chu Toulouse
city: Bron
country: France
facility: Hopital Louis Pradel
city: Lille
country: France
facility: CHRU Lille
city: Lyon
country: France
facility: Centre Leon Berard
city: Montpellier
country: France
facility: CHU Montpellier
city: Nice
country: France
facility: Centre Antoine Lacassagne Centre Régional de Lutte Contre Le Cancer
city: Paris
country: France
facility: Hopital Tenon
city: Pessac
country: France
facility: CHU Bordeaux
city: Saint Quentin
country: France
facility: CH de Saint Quentin
city: Strasbourg
country: France
facility: Chru de Strasbourg
city: Toulon
country: France
facility: Hia Sainte Anne
city: Berlin
country: Germany
facility: Evangelische Lungenklinik Berlin
city: Berlin
country: Germany
facility: Charité Universitätsmedizin Berlin, Med Klinik Infekto und Pneumo
city: Berlin
country: Germany
facility: Helios Klinikum Emil von Behring GmbH
city: Braunschweig
country: Germany
facility: Klinikum Braunschweig
city: Essen
country: Germany
facility: KEM/Evang. Kliniken Essen Mitte gGmbH
city: Essen
country: Germany
facility: Universitätsklinikum Essen
city: Esslingen
country: Germany
facility: Klinikum Esslingen
city: Gauting
country: Germany
facility: Asklepios Fachkliniken GmbH
city: Großhansdorf
country: Germany
facility: LungenClinic Großhansdorf GmbH
city: Halle
country: Germany
facility: Krankenhaus Martha-Maria Halle-Doelau gGmbH
city: Heidelberg
country: Germany
facility: Thoraxklinik Heidelberg gGmbH
city: Hemer
country: Germany
facility: Lungenklinik Hemer
city: Homburg
country: Germany
facility: Universität Des Saarlandes
city: Immenhausen
country: Germany
facility: Lungenfachklinik Immenhausen
city: Kiel
country: Germany
facility: Uniklinik Schleswig-Holstein
city: Köln
country: Germany
facility: Klinikum Koeln-Merheim
city: Löwenstein
country: Germany
facility: SLK Kliniken Heilbronn GmbH, Standort Fachklinik Löwenstein
city: Lübeck
country: Germany
facility: Universitätsklinikum Schleswig-Holstein
city: Mannheim
country: Germany
facility: Universität Mannheim
city: München
country: Germany
facility: Klinikum Bogenhausen
city: Münster
country: Germany
facility: Universitätsklinikum Münster, Medizinische Klinik A, Translationale Onkologie
city: Oldenburg
country: Germany
facility: Pius Hospital Oldenburg
city: Regensburg
country: Germany
facility: Universitätsklinikum Regensburg
city: Würzburg
country: Germany
facility: Klinikum Würzburg Mitte gGmbH
city: Athens
country: Greece
facility: Uoa Sotiria Hospital
city: Athens
country: Greece
facility: Errikos Dynan Hospital
city: Faliro
country: Greece
facility: Metropolitan Hospital Fourth Oncology Clinic
city: Larissa
country: Greece
facility: University Hospital of Larissa
city: Thessaloniki
country: Greece
facility: Theageneio Hospital
city: Thessaloniki
country: Greece
facility: Ag. Loukas Hospital
city: Hong Kong
country: Hong Kong
facility: Hong Kong Integrated Oncology Centre
city: Hong Kong
country: Hong Kong
facility: Queen Mary Hospital
city: Hong Kong
country: Hong Kong
facility: Tuen Mun Hospital
city: Shatin
country: Hong Kong
facility: Prince of Wales Hosp
city: Catanzaro
country: Italy
facility: Az. Osp. Pugliese Ciaccio
state: Calabria
city: Bologna
country: Italy
facility: AZ.Osp S. Orsola ? Malpighi-Reparto di Oncologia Medica
state: Emilia-Romagna
city: Parma
country: Italy
facility: A.O. Universitaria Di Parma
state: Emilia-Romagna
city: Ravenna
country: Italy
facility: AUSL della Romagna
state: Emilia-Romagna
city: Udine
country: Italy
facility: Azienda Sanitaria Universitaria Friuli Centrale ? PO Universitario Santa Maria della Misericordia
state: Friuli-Venezia Giulia
city: Roma
country: Italy
facility: IRCCS Istituto Regina Elena (IFO)
state: Lazio
city: Genova
country: Italy
facility: Ospedale Policlinico San Martino
state: Liguria
city: Bergamo
country: Italy
facility: Asst Papa Giovanni XXIII
state: Lombardia
city: Rozzano (MI)
country: Italy
facility: IRCCS Istituto Clinico Humanitas
state: Lombardia
city: Novara
country: Italy
facility: A.O.U. Maggiore della Carità
state: Piemonte
city: Bari
country: Italy
facility: Irccs Ist. Tumori Giovanni Paolo Ii
state: Puglia
city: Sassari
country: Italy
facility: Ospedale Civile SS Annunziata
state: Sardegna
city: Palermo
country: Italy
facility: AO Ospedali Riuniti Villa Sofia-Cervello-Presidio Ospedaliero Cervello
state: Sicilia
city: Firenze
country: Italy
facility: Azienda Ospedaliero-Universitaria Careggi
state: Toscana
city: Pisa
country: Italy
facility: Azienda Ospedaliero Universitaria Pisana
state: Toscana
city: Padova
country: Italy
facility: IRCCS Istituto Oncologico Veneto (IOV)
state: Veneto
city: Ehime
country: Japan
facility: Shikoku Cancer Center
city: Fukuoka
country: Japan
facility: Kyushu University Hospital
city: Hokkaido
country: Japan
facility: Hokkaido University Hospital
city: Miyagi
country: Japan
facility: Sendai Kousei Hospital
city: Niigata
country: Japan
facility: Niigata Cancer Center Hospital
city: Okayama
country: Japan
facility: Okayama University Hospital
city: Osaka
country: Japan
facility: Kindai University Hospital
city: Shizuoka
country: Japan
facility: Shizuoka Cancer Center
city: Tokyo
country: Japan
facility: National Cancer Center Hospital
city: Tokyo
country: Japan
facility: The Cancer Institute Hospital of JFCR
city: Wakayama
country: Japan
facility: Wakayama Medical University Hospital
city: Busan
country: Korea, Republic of
facility: Pusan National University Hospital
city: Cheongju-si
country: Korea, Republic of
facility: Chungbuk National University Hospital
city: Daegu
country: Korea, Republic of
facility: Kyungpook National University Chilgok Hospital
city: Daegu
country: Korea, Republic of
facility: Keimyung University Dongsan Medical Center
city: Gyeonggi-do
country: Korea, Republic of
facility: St. Vincent's Hospital
city: Gyeongsangnam-do
country: Korea, Republic of
facility: Pusan National University Yangsan Hospital
city: Incheon
country: Korea, Republic of
facility: Gachon University Gil Medical Center
city: Jeollanam-do
country: Korea, Republic of
facility: Chonnam National University Hwasun Hospital
city: Seongnam-si
country: Korea, Republic of
facility: Seoul National University Bundang Hospital
city: Seoul
country: Korea, Republic of
facility: Korea University Anam Hospital
city: Seoul
country: Korea, Republic of
facility: Seoul National University Hospital
city: Seoul
country: Korea, Republic of
facility: Samsung Medical Center
city: Seoul
country: Korea, Republic of
facility: Korea University Guro Hospital
city: Saltillo
country: Mexico
facility: Centro de Infusion E Investigacion Oncologia de Saltillo Sc
state: Coahuila
city: Guadalajara
country: Mexico
facility: Hospital Civil de Guadalajara Fray Antonio Alcalde
state: Jalisco
city: Heroica Puebla de Zaragoza
country: Mexico
facility: Clínica Integral Internacional de Oncología S de RL de CV
state: Puebla
city: Santiago de Querétaro
country: Mexico
facility: PanAmerican Clinical Research, Querétaro
state: Queretaro
city: Ciudad de México
country: Mexico
facility: ARKE Estudios Clínicos S.A. de C.V.
city: 'S Hertogenbosch
country: Netherlands
facility: Jeroen Bosch Ziekenhuis
city: Arnhem
country: Netherlands
facility: Ziekenhuis Rijnstate
city: Breda
country: Netherlands
facility: Amphia Ziekenhuis
city: Harderwijk
country: Netherlands
facility: Ziekenhuis St. Jansdal
city: Leidschendam
country: Netherlands
facility: Medisch Centrum Haaglanden, locatie Antoniushove
city: Zwolle
country: Netherlands
facility: Isala
city: ?ód?
country: Poland
facility: Instytut "Centrum Zdrowia Matki Polki"
city: Bydgoszcz
country: Poland
facility: Kujawsko-Pomorskie Centrum Pulmonologii
city: Gdansk
country: Poland
facility: Uniwersyteckie Centrum Kliniczne, Klinika Onkologii i Radioterapii
city: Kraków
country: Poland
facility: Krakowski Szpital Specjalistyczny im sw. Jana Paw?a II
city: Lublin
country: Poland
facility: Uniwersytecki Szpital Kliniczny nr 4 w Lublinie
city: Olsztyn
country: Poland
facility: Warminsko-Mazurskie Centrum Chorób P?uc w Olsztynie
city: Poznan
country: Poland
facility: Wielkopolskie Centrum Pulmonologii i Torakochirurgii w Poznaniu
city: Radom
country: Poland
facility: Radomskie Centrum Onkologii
city: Warszawa
country: Poland
facility: Instytut Gruzlicy I Chorob Pluc
city: Warszawa
country: Poland
facility: Narod.Inst.Onkol. im. M.Sklodowskiej - Curie-Panst.Inst.Bad
city: Wroc?aw
country: Poland
facility: Dolno?L?Skie Centrum Onkologii, Pulmonologii I Hematologii
city: Braga
country: Portugal
facility: Hospital de Braga
city: Coimbra
country: Portugal
facility: CHUC - Unidade de Pneumologia Oncológica
city: Lisboa
country: Portugal
facility: Centro Clinico Champalimaud
city: Porto
country: Portugal
facility: Centro Hospitalar do Porto ? Hospital de Santo António
city: Porto
country: Portugal
facility: IPO do Porto
city: Singapore
country: Singapore
facility: National Cancer Centre
city: Singapore
country: Singapore
facility: Curie Oncology (Farrer)
city: Hospitalet de Llobregat
country: Spain
facility: Institut Catala d Oncologia Hospitalet
state: Barcelona
city: Seville
country: Spain
facility: Hospital Nuestra Senora de Valme
state: Sevilla
city: Barcelona
country: Spain
facility: Hospital de la Santa Creu i Sant Pau
city: Barcelona
country: Spain
facility: Hospital Vall Hebron
city: Madrid
country: Spain
facility: Hospital General Universitario Gregorio Marañon
city: Madrid
country: Spain
facility: Hospital Universitario La Paz
city: Malaga
country: Spain
facility: Hospital Regional Universitario de Malaga
city: Valencia
country: Spain
facility: Hospital Universitario la Fe
city: Zaragoza
country: Spain
facility: Hospital Universitario Miguel Servet
city: Gävle
country: Sweden
facility: Gävle Sjukhus
city: Hsinchu City
country: Taiwan
facility: Hsin-Chu Branch of National Taiwan University Hospital
city: Kaohsiung
country: Taiwan
facility: Kaohsiung Medical University Chung-Ho Memorial Hospital
city: Taichung
country: Taiwan
facility: Chung Shan Medical University Hospital
city: Taipei
country: Taiwan
facility: National Taiwan University Hospital
city: Taipei
country: Taiwan
facility: Taipei Veterans General Hospital
city: Taoyuan
country: Taiwan
facility: Chang Gung Medical Foundation - Linkou
city: Bangkok
country: Thailand
facility: Vajira Hospital
city: Bangkok
country: Thailand
facility: Siriraj Hospital - Chulabhorn Bone Marrow Transplant Centre
city: Khon Kaen
country: Thailand
facility: Srinagarind Hospital
city: Songkhla
country: Thailand
facility: Songklanagarind Hospital
city: Blackpool
country: United Kingdom
facility: Blackpool Victoria Hospital
city: Cambridge
country: United Kingdom
facility: Addenbrooke's Hospital
city: Cardiff
country: United Kingdom
facility: Velindre NHS Trust - Velindre Cancer Centre
city: Cottingham
country: United Kingdom
facility: Castle Hill Hospital
city: Glasgow
country: United Kingdom
facility: Beatson West of Scotland Cancer Centre
city: Leeds
country: United Kingdom
facility: St James University Hospital
city: London
country: United Kingdom
facility: Guy's Hospital - Cancer Centre
city: London
country: United Kingdom
facility: Royal Marsden Hospital - London
city: Manchester
country: United Kingdom
facility: The Christie NHS Foundation Trust
city: Nottingham
country: United Kingdom
facility: Nottingham City Hospital
city: Stoke-On-Trent
country: United Kingdom
facility: University Hospitals of North Midlands NHS Trust-Royal Stoke University Hospital
city: Sutton
country: United Kingdom
facility: Royal Marsden Hospital (Sutton)
city: Torquay
country: United Kingdom
facility: Torbay Hospital
Study officials:
affiliation: Hoffmann-La Roche
name: Clinical Trials
role: STUDY_DIRECTOR
References: