louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT02487056: Patient Journey in Hospital With Heart Failure in Turkish Population
Official title: A Multicentre, Prospective, Observational, Hospital-based Registry of Patients With Acute Heart Failure Those Whose Care Was Guided by a Cardiologist in Turkey
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Heart Failure
Keywords: Heart Failure
Diagnosis
Management
Lead sponsor: Ege University
Sponsor class: OTHER
First posted: 2015-07-01
Enrollment: 1622
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: Hospitalized patients with acute heart failure

Brief summary: The purpose of this study is to compose a national database of the etiologies, clinical and demographic characteristics, using diagnostic tests, precipitating and risk factors, management of from intensive care unit or coronary care unit to hospital discharge, length of stay in the intensive care unit and hospital, in-hospital mortality and discharge medications of hospitalized acute heart failure patients in Turkish population.

Detailed description: The etiologies, precipitating factors, demographics, clinical characteristics, management and outcome of patients admitted in hospital with acute heart failure in Turkish population will be recorded.

Eligibility criteria: Inclusion Criteria:

* Patients \>18 years olds
* Clinical diagnosis of acute heart failure
* Admitted to the participating hospitals

Exclusion Criteria:

* Patients \<18 years old
* Patients with acute heart failure who are discharged from the emergency room without admission.
* Failure to obtain informed consent

Primary outcomes:
measure: Adherence to European Heart Failure Guideline
timeFrame: Admission to Hospital (Enrollment)
Secondary outcomes:
measure: Length of Hospitalisation
timeFrame: In-Hospital
measure: Mortality
timeFrame: 1 month
Other outcomes:
Locations:
city: İstanbul
country: Turkey
facility: Ahmet Ekmekçi
Study officials:
affiliation: Dr. Siyami Ersek Göğüs Kalp Ve Damar Cerrahisi Eğitim Ve Araştırma Hastanesi
name: Ahmet Ekmekçi, MD
role: STUDY_CHAIR
References:
citation: Sinan UY, Ekmekci A, Ozbay B, Akyildiz Akcay F, Bekar L, Koza Y, Bolat I, Kocabas U, Zoghi M; Collaborators. The real-life data of hospitalized patients with heart failure: On behalf of the Journey HF-TR study investigators. Anatol J Cardiol. 2019 Jan;21(1):25-30. doi: 10.14744/AnatolJCardiol.2018.50880.
citation: Sabanoglu C, Sinan UY, Akboga MK, Coner A, Gok G, Kocabas U, Bekar L, Gazi E, Cengiz M, Kilic S, Inanc IH, Cakmak HA, Zoghi M. Long-Term Prognosis of Patients with Heart Failure: Follow-Up Results of Journey HF-TR Study Population. Anatol J Cardiol. 2023 Jan;27(1):26-33. doi: 10.14744/AnatolJCardiol.2022.2171.
Clinical trial NCT02805556: Absolute Bioavailability of BMS-626529 After Oral and Intravenous Dosing
Official title: Study of the Absolute Bioavailability of BMS-626529 in Healthy Subjects Following Oral Dosing of BMS-663068 and Intravenous Dosing of BMS-626529
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE1
Conditions: Infection, Human Immunodeficiency Virus
Lead sponsor: ViiV Healthcare
Sponsor class: INDUSTRY
Collaborators: name: GlaxoSmithKline
First posted: 2016-06-20
Enrollment: 36
Sex: MALE
Minimum age (years): 18
Maximum age (years): 50
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: TREATMENT

Brief summary: A phase I absolute bioavailability study of BMS-626529 following oral and intravenous dosing


Eligibility criteria: Inclusion Criteria:

* Generally healthy
* BMI 18.0-32.0 kg/m2
* Men sexually active with women of childbearing potential must follow instructions for contraception for the duration of treatment plus 90 days
* Men must refrain from sperm donation for the length of the study and for 90 days
* Sign informed consent

Exclusion Criteria:

* Significant medical illness
* Tobacco use in the last 12 months
* Major surgery within 4 weeks of study administration
* Donation of blood within 4 weeks of study administration
* Current or recent (within 3 months of study administration) of gastrointestinal disease

Primary outcomes:
measure: The absolute bioavailability of BMS-626529 after single oral (BMS-663068) and single intravenous dosing ([13C]-BMS-626529) by assessing the primary endpoints AUC(inf)
timeFrame: up to 11 days
Secondary outcomes:
measure: Safety and tolerability of single oral dose of BMS-663068 as determined by medical review of adverse event reports, vital sign measurements, electrocardiograms (ECGs), and results of physical examination and laboratory tests
timeFrame: up to 31 days
measure: Safety and tolerability of single intravenous dose of [13C]-BMS-626529 as determined by medical review of adverse event reports, vital sign measurements, electrocardiograms (ECGs), and results of physical examination and laboratory tests
timeFrame: up to 31 days
Other outcomes:
Locations:
city: Lisburn
country: United Kingdom
facility: GSK Investigational Site
Study officials:
affiliation: ViiV Healthcare
name: GSK Clinical Trials
role: STUDY_DIRECTOR
References:
Clinical trial NCT01453556: Intracorporeal Versus Extracorporeal Mechanical Anastomosis in Laparoscopic Right Colectomy
Official title: Intracorporeal Versus Extracorporeal Mechanical Anastomosis in Laparoscopic Right Colectomy. A Prospective Randomized Controlled Clinical Trial
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Neoplastic or Benign Disease of Right Colon
Elective Laparoscopic Surgery
Keywords: Laparoscopic surgery
Right colectomy
Mechanical anastomosis
Post-operative ileum
Lead sponsor: Scientific Institute San Raffaele
Sponsor class: OTHER
First posted: 2011-10-18
Enrollment: 158
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: Verify with a prospective randomised trial if intracorporeal mechanical anastomosis in laparoscopic right colectomy reduces post-operative bowel canalisation time and length of stay in comparison with extracorporeal mechanical anastomosis.


Eligibility criteria: Inclusion Criteria:

* Age 18 or more
* Benign o neoplastic disease of right colon
* Elective laparoscopic surgery

Exclusion Criteria:

* Emergency surgery
* Adhesion or infiltration of near organs
* Severe heart disease ( New York Heart Association class \> 3 )
* Severe respiratory disease ( arterial PO2 \< 70 torr )
* Severe Liver disease (Child-Pugh class C)
* Ongoing infections
* Number of plasmatic neutrophil \< a 2.0 x 10 9/L
* Other contraindications to laparoscopy

Primary outcomes:
measure: Post-operative canalisation time and length of stay
timeFrame: Post-operative stay (about 7 days)
Secondary outcomes:
measure: Impact of post-operative ileum and complications. Valuation of global costs
timeFrame: 12 months
Other outcomes:
Locations:
city: Milan
country: Italy
facility: San Raffaele Scientific Institute
state: MI
Study officials:
affiliation: San Raffaele Scientific Institute
name: Andrea Vignali, MD
role: PRINCIPAL_INVESTIGATOR
affiliation: San Raffaele Scientific Institute
name: Carlo Staudacher, Prof
role: STUDY_DIRECTOR
References:
Clinical trial NCT01313156: LUPS-Lipids and Glucose Under Prospective Surveillance
Official title: Lipids and Glucose Under Prospective Surveillance
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Metabolic Syndrome
Type 2 Diabetes
Keywords: Metabolic Syndrome, Syndrome X, MetS,
Type 2 Diabetes
Lead sponsor: Asklepios proresearch
Sponsor class: INDUSTRY
Collaborators: name: City of Hamburg
name: Universitätsklinikum Hamburg-Eppendorf
First posted: 2011-03-11
Enrollment: 1962
Sex: ALL
Minimum age (years): 25
Maximum age (years): 60
Standard ages: ADULT
Accepts healthy volunteers: yes
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: so-called "Healthy-Workers", aged 25-60years, of Lufthansa-Technik, Hamburg, Germany, who voluntarily aggreed to participate in the study.

Brief summary: Prospective, non-randomized cohort study to analyse genetic variations, dietary patterns, perceived stress and anxiety and early changes in lipid metabolism leading to the metabolic syndrome and type 2 diabetes

Detailed description: The LUPS-study is a collaboration between Asklepios Clinics Hamburg GmbH and University Clinic Hamburg Eppendorf, Germany. This study is assessing a multitude of serum biomarkers, anthropometrics, dietary habits, physical activity, perceived stress along with genetic information from "healthy workers" (25-60years) to better understand phenotype-genotype associations leading to MetS and type 2 diabetes.

Eligibility criteria: Inclusion Criteria:

* 25-60 years men and women willing to give consent

Exclusion Criteria:

* diabetes (type 1 or 2)

Primary outcomes:
measure: Metabolic Syndrome, Type 2 Diabetes
timeFrame: 10 years
Secondary outcomes:
Other outcomes:
Locations:
city: Hamburg
country: Germany
facility: Asklepios Klinik St.Georg
city: Hamburg
country: Germany
facility: Universitätsklinikum Eppendorf
Study officials:
affiliation: Asklepios Klinik St.Georg, Hamburg, Germany
name: Dirk Mueller-Wieland, Prof., MD
role: PRINCIPAL_INVESTIGATOR
affiliation: Universitätsklinikum Hamburg-Eppendorf, Germany
name: Karl Wegscheider, Prof., PHD
role: PRINCIPAL_INVESTIGATOR
References:
citation: Muller-Wieland D, Altenburg C, Becher H, Burchard J, Frisch A, Gebhard J, Haas J, Harth V, Heeren J, Hengelbrock J, von Karais M, Knebel B, Kotzka J, Lowe B, Marx N, Pinnschmidt H, Preisser A, Rose M, Sawitzky-Rose B, Scheja L, Terschuren C, Toller M, Vettorazzi E, Wegscheider K. Development of the Metabolic Syndrome: Study Design and Baseline Data of the Lufthansa Prevention Study (LUPS), A Prospective Observational Cohort Survey. Exp Clin Endocrinol Diabetes. 2020 Dec;128(12):777-787. doi: 10.1055/a-0767-6361. Epub 2018 Nov 26.
Clinical trial NCT04639856: ICU Stay in Patients With Low Ejection Fraction Undergoing Cardiac Revascularization: Comparison of On-pump vs Off-pump Coronary Artery Bypass Grafting
Official title: ICU Stay in Patients With Low Ejection Fraction Undergoing Cardiac Revascularization: Comparison of On-pump vs Off-pump Coronary Artery Bypass Grafting
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Cardiac Revascularization
Keywords: Coronary Artery Bypass Grafting
Lead sponsor: Armed Forces Institute of Cardiology, Pakistan
Sponsor class: OTHER
First posted: 2020-11-23
Enrollment: 60
Sex: ALL
Minimum age (years): 40
Maximum age (years): 80
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: Coronary artery bypass graft (CABG) surgery can result in severe postoperative complications, such as renal and pulmonary failure. In about 80% of the cases worldwide, it is currently performed with cardiopulmonary bypass (CPB) with cardiac arrest. Cardiopulmonary bypass leads to a systemic inflammatory response, which may be induced by the contact of circulating blood with artificial surfaces of the extracorporeal circuit.\[1\] To reduce postoperative complications caused by systemic inflammation, off-pump CABG was reintroduced into clinical practice in the early 1990s. During off-pump surgery, the coronary artery grafts are placed on coronaries of a beating heart, thereby avoiding aortic cross clamping and CPB. \[1\] There are many studies and debates about the two approaches to cardiac revascularization via CABG. This study aims to answer the question as to difference in the ICU stay of patients with low ejection fraction undergoing cardiac revascularization bet ween off pump and on pump coronary artery bypass grafting and better treatment option shall be adopted in future.


Eligibility criteria: Inclusion Criteria:

* All patients of either gender between the ages of 40 to 80
* Ejection fraction of less than or equal to 35% undergoing CABG.
* undergoing CABG.

Exclusion Criteria:

* Patients with ejection fraction of more than 35%
* Patients with previous history of cardiac revascularization
* Patients with previous history of chronic kidney disease and obstructive sleep apnea.

Primary outcomes:
measure: ICU Stay
timeFrame: 6 Months
Secondary outcomes:
Other outcomes:
Locations:
city: Rawalpindi
country: Pakistan
facility: Armed Forces Institute of Cardiology, Rawalpindi
Study officials:
References:
Clinical trial NCT01239056: Evaluation of Pancreatic Pseudocyst Drainage With a Metal Stent
Official title: Prospective Evaluation of the Clinical Utility of Pseudocyst Drainage With Metal Stent
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Pancreatic Pseudocysts
Lead sponsor: University of Florida
Sponsor class: OTHER
First posted: 2010-11-11
Enrollment: 22
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: CASE_ONLY
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Patients who have a medical indication for endoscopic drainage of pancreatic pseudocyst and are referred for the procedure as part of their standard medical care will be considered for the study.

Brief summary: The purpose of this study is to study the evaluation of the effectiveness of endoscopic Pancreatic Pseudocyst drainage using a metal stent.


Eligibility criteria: Inclusion Criteria:

1. Subject is 18 years or older
2. Subject has pancreatic pseudocyst
3. Subject has medical indication for drainage of the pancreatic pseudocyst
4. Subject must be able to give informed consent

Exclusion Criteria:

1. Any contraindication to endoscopic pseudocyst drainage
2. Subject is unable to give informed consent

Primary outcomes:
measure: Technical Success of Endoscopic Ultrasound-guided Single-access Pseudocyst Drainage With a Fully Covered Self-expanding Metal Stent ; Anchored With a Double Pigtail Plastic Stent Inserted Through the Metal Stent Lumen
timeFrame: baseline
Secondary outcomes:
measure: Resolution of Pancreatic Pseudocyst After Placement of Fully Covered Self-expanding Metal Stent (CSEMS).
timeFrame: 6 to 12 weeks after baseline
measure: Adverse Events
timeFrame: 1 year
Other outcomes:
Locations:
city: Gainesville
country: United States
facility: Shands UF Endoscopy
state: Florida
Study officials:
affiliation: University of Florida
name: Peter V draganov, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT02139956: Assessment of the Internal Urethral Sphincter and the Vagina by Three Dimensional Ultrasound
Official title: Ultrasonic Assessment of the Urethra and the Vagina in Normal Continent Women and Women Suffering From Stress Urinary Incontinence
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Urinary Incontinence Due to Urethral Sphincter Incompetence
Lead sponsor: Ain Shams University
Sponsor class: OTHER
First posted: 2014-05-16
Enrollment: 140
Sex: FEMALE
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: CASE_CONTROL
Time perspective: CROSS_SECTIONAL
Sampling method: NON_PROBABILITY_SAMPLE
Study population: out patient \[clinics\] and in patient

Brief summary: Continent women have an intact internal urethral sphincter that extends from the bladder neck down to the perineal membrane. The internal urethral sphincter is a strong collagen muscle tissue cylinder lined by urothelium. On ultrasound scanning tissue echo will be detected torn internal urethral sphincter will not stand sudden rise of abdominal pressure. Three dimensional ultrasound assessment of the internal urethral sphincter is very sensitive and specific for the diagnosis of stress urinary incontinence.

Detailed description: The internal urethral sphincter used to be said it's a muscular ring but the investigators will visualize by three dimensional ultrasound it's a cylinder in shape and it's the cause of stress urinary incontinence by being torn by stretching the vagina during normal delivery.

Eligibility criteria: Inclusion Criteria:

* signed an informed consent
* patient with stress urinary incontinence
* patient have done a vaginal delivery
* patient with genital prolapse

Exclusion Criteria:

* refusal to sign an informed consent
* patient have urinary tract infection
* patient with pregnancy
* patient have vaginal infection
* patient who has undiagnosed vaginal bleeding

Primary outcomes:
measure: evaluation of the internal urethral sphincter and assesst the extend and degree of the torn internal urethral sphincter
timeFrame: 6 month
Secondary outcomes:
Other outcomes:
Locations:
city: Cairo
country: Egypt
facility: Ain Shams University
Study officials:
References:
citation: Kruger JA, Dietz HP, Budgett SC, Dumoulin CL. Comparison between transperineal ultrasound and digital detection of levator ani trauma. Can we improve the odds? Neurourol Urodyn. 2014 Mar;33(3):307-11. doi: 10.1002/nau.22386. Epub 2013 Feb 22.
Clinical trial NCT06268756: Fear of Other's Judgment, Self-esteem and Use of Social Networks Among Students
Official title: Fear of Other's Judgment, Self-esteem and Use of Social Networks Among Students
Study type: OBSERVATIONAL
Overall status: RECRUITING
Conditions: Self-esteem
Keywords: Fear of judgment
self-esteem
social networks
student
Lead sponsor: Université de Reims Champagne-Ardenne
Sponsor class: OTHER
First posted: 2024-02-20
Enrollment: 500
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: CASE_ONLY
Time perspective: CROSS_SECTIONAL
Sampling method: NON_PROBABILITY_SAMPLE
Study population: students using social networks

Brief summary: Fear of being judged negatively by others can lead to avoidance of social situations or even social isolation. If the intensity of this fear is excessive and results in significant impairment of functioning or significant suffering, the subject may suffer from social anxiety.

The considerable growth of social networks in a decade has led to the emergence of new behaviors among young people. Individuals spend on average 2 hours and 27 minutes per day with differences in usage: time spent, social network used, function sought. The use of these networks may be reasonable and moderate but may also be excessive and abusive (Amnon, 2014). Some authors even talk about addiction or dependence on social networks (Perales and Billieux, 2020) even if the existence of this disorder is not consensus.

People who fear being judged negatively by others may be more at risk of misuse of social networks. Indeed, the use of social networks would compensate for their existing problems (Kardefelt-Winther, 2014) and would thus be a new emotional management strategy. It would also reduce dreaded social situations such as face-to-face exchanges (Weidman and Rodebaugh, 2012; Yen and Ko, 2012). Self-esteem is defined as a subjective judgment of oneself in relation to one's values and vision of the real and ideal self (Rosenberg. 1979). The greater the gap between the vision of the real self and the ideal self, the lower the self-esteem.

Detailed description: The objective of the study is to study the influence of self-esteem on the association between the fear of being judged negatively by others and the use of social networks.

Eligibility criteria: Inclusion Criteria:

* over 18 years of age
* students at a French school or university
* using social media
* agreeing to participate in the study

Exclusion Criteria:

* Protected by law
* Refusing to participate in the study

Primary outcomes:
measure: Rosenberg Self-esteem Scale
timeFrame: Day 0
Secondary outcomes:
Other outcomes:
Locations:
city: Reims
country: France
facility: Ufr Medecine Urca
city: Reims
country: France
facility: Université de Reims Champagne Ardenne
Study officials:
affiliation: Université de Reims Champagne-Ardenne
name: JULIEN SWEERTS Sabrina
role: STUDY_DIRECTOR
References:
Clinical trial NCT00451009: Safety and Efficacy of Freezing and Thawing of Human Eggs in Assisted Reproductive Technology
Official title: Safety and Effectiveness of Freeze and Thaw Media Kits for the Manufacturing of Oocytes for Future Use in Assisted Reproductive Technology
Study type: INTERVENTIONAL
Overall status: WITHDRAWN
Phase: NA
Conditions: Infertility
Keywords: IVF
Male factor infertility
Cryopreservation
Cryoprotective agents
Egg Freezing
Lead sponsor: ViaCell
Sponsor class: INDUSTRY
First posted: 2007-03-22
Enrollment: 0
Sex: FEMALE
Minimum age (years): 21
Maximum age (years): 35
Standard ages: ADULT
Accepts healthy volunteers: no
Allocation: NON_RANDOMIZED
Intervention model: SINGLE_GROUP
Primary purpose: TREATMENT

Brief summary: The purpose of this study is to determine the effectiveness of the ViaCell's product media for freezing and thawing human eggs for future use in assisted reproductive technology.

Detailed description: ViaCell's product is an investigational product intended to broaden reproductive options for women through freezing and thawing of human eggs. The egg is a large cell with a high water content, historically making it difficult to freeze. It uses a choline chloride-based media designed to protect the cells from damage during the freezing process with the goal of making it possible to successfully store and thaw eggs for future use.

Following informed consent, female subjects will be screened according to the inclusion/exclusion criteria of the protocol and eligible subjects will undergo hormonal stimulation using standard IVF drugs.

Eligibility criteria: Inclusion Criteria:

* Women 21-35 years of age
* Women with male factor infertility seeking IVF treatment
* Negative history of female infertility
* Non-smoking for at least 1 year

Exclusion Criteria:

* Greater than one miscarriage
* More than one previous failed IVF attempt

Primary outcomes:
measure: Live birth
Secondary outcomes:
Other outcomes:
Locations:
city: San Ramon
country: United States
facility: Reproductive Science Center
state: California
city: South Miami
country: United States
facility: South Florida Institute for Reproductive Medicine
state: Florida
city: Iowa City
country: United States
facility: University of Iowa Hospitals and Clinics, Center for Advanced Reproductive Care
state: Iowa
city: Waltham
country: United States
facility: Boston IVF
state: Massachusetts
Study officials:
References: