louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT02601456: Changes in Trans Tibial Amputee Running Asymmetry During Prolonged Effort
Official title: The Effect of Prolonged Effort on the Bilateral Asymmetry in Trans Tibial Amputee Running With Running Specific Prosthesis
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Amputation, Traumatic
Keywords: Amputation, Traumatic
Biomechanics
Asymmetry
Amputee Running
Prolonged Effort
Lead sponsor: Sheba Medical Center
Sponsor class: OTHER_GOV
First posted: 2015-11-10
Enrollment: 10
Sex: ALL
Minimum age (years): 20
Maximum age (years): 60
Standard ages: ADULT
Accepts healthy volunteers: no
Observational model: CASE_ONLY
Time perspective: CROSS_SECTIONAL
Sampling method: NON_PROBABILITY_SAMPLE
Study population: community sample

Brief summary: The purpose of this study is to determine the effect of prolonged effort in long distance running on the biomechanical bilateral asymmetry in the lower limbs of trans tibial amputee running with running specific prosthesis.


Eligibility criteria: Inclusion Criteria:

* Unilateral traumatic trans tibial amputee.
* Experience in running with running specific prosthesis.
* Ability to run for at least 20 minutes.

Exclusion Criteria:

* Injury or other orthopedic or neurologic issue that compromises the gait.

Primary outcomes:
measure: The changes in step length asymmetry after prolonged effort in running on a treadmill.
timeFrame: Several measurements during 20-30 minutes run.
measure: The changes in contact time asymmetry after prolonged effort in running on a treadmill.
timeFrame: Several measurements during 30 minutes run.
measure: The changes in flight time asymmetry after prolonged effort in running on a treadmill.
timeFrame: Several measurements during 30 minutes run.
measure: The changes in hip angles asymmetry after prolonged effort in running on a treadmill.
timeFrame: Several measurements during 30 minutes run.
measure: The changes in knee angles asymmetry after prolonged effort in running on a treadmill.
timeFrame: Several measurements during 30 minutes run.
measure: The changes in vertical ground reaction force asymmetry after prolonged effort in running. on a treadmill
timeFrame: Several measurements during 30 minutes run.
measure: The changes in ground reaction impulse asymmetry after prolonged effort in running on a treadmill.
timeFrame: Several measurements during 30 minutes run.
Secondary outcomes:
Other outcomes:
Locations:
city: Ramat Gan
country: Israel
facility: Sheba Medical Center
Study officials:
affiliation: Sheba Medical Center
name: Itzhak Ziev-Ner, Dr.
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT04522856: Anaesthesiological Routine Care for Thrombectomy in Cerebral Ischaemia
Official title: Anaesthesiological Routine Care for Thrombectomy in Cerebral Ischaemia
Study type: OBSERVATIONAL
Overall status: RECRUITING
Conditions: Cerebral Ischemia
Keywords: Endovascular thrombectomy
acute ischaemic stroke
large-vessel occlusion
Lead sponsor: European Society of Anaesthesiology
Sponsor class: OTHER
First posted: 2020-08-21
Enrollment: 2500
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: CASE_ONLY
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: The target population consists of patients undergoing emergency endovascular thrombectomy for treatment of AIS-LVO. The planned minimum sample size is 5,000 patients.

Brief summary: Endovascular thrombectomy is the standard of care for acute ischaemic stroke due to large-vessel occlusion. Current guidelines for periprocedural anaesthesiological care give gross recommendations on management of stroke patients during recanalization, but lack detailed information.

To determine how anaesthesiologists support endovascular thrombectomy with regard to anaesthetic technique, choice of substances, haemodynamic management, and ventilation. With a multivariate analysis, the investigators will look for the factors of anesthetic management that are independently correlated with a good or bad outcome.

Detailed description: see brief summary

Eligibility criteria: Inclusion Criteria:

* Endovascular stroke treatment involving anaesthesia care

Exclusion Criteria:

* In-hospital onset of stroke
* Inclusion in an interventional study concerning the anaesthesia protocol
* Age under 18 years

Primary outcomes:
measure: Neurological outcome 90 days after the stroke
timeFrame: 90 days
Secondary outcomes:
measure: Mortality
timeFrame: 90 days
measure: Grade of recanalization
timeFrame: sixty minutes
measure: Duration
timeFrame: 30 Minutes
measure: Proportion of patients breathing spontaneously
timeFrame: sixty minutes
Other outcomes:
Locations:
city: München
country: Germany
facility: TU München
Study officials:
affiliation: Senior Physician-München, Germany
name: Andreas Ranft, Dr.
role: STUDY_CHAIR
References:
Clinical trial NCT00802256: Comparative Evaluation of Pulpotomized Primary Molars With Mineral Trioxide Aggregate and New Endodonthic Cement
Official title: Comparative Evaluation of Pulpotomized Primary Molars With Mineralized Trioxide Aggregate & New Endodonthic Cement
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: PHASE3
Conditions: Pulpotomy Treatment
Keywords: pulpotomy
primary molar teeth
MTA
NEC
CEM
Primary Molar Teeth Which Require Pulpotomy Treatment
Lead sponsor: Shahid Beheshti University of Medical Sciences
Sponsor class: OTHER
Collaborators: name: Iranian center for endodontic research
First posted: 2008-12-04
Enrollment: 80
Sex: ALL
Minimum age (years): 4
Maximum age (years): 8
Standard ages: CHILD
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: A new Endodontic Cement (NEC) is being compared with mineral trioxide aggregate in pulpotomy of primary molars.

Detailed description: Forty patient are selected randomly. Each patient has at least 2 teeth which require pulpotomy treatment. After removing of carious teeth by a low speed round bur and pulp exposure, roof of pulp chamber is removed completely by a high speed 008 fissure bur. Life tissues of pulp are removed by sharp excavator and rinsing with normal salin. Hemostat is achieved and cavity will be cleaned by 0.5% hypo chlorate solution. MTA or NEC material is mixed according to manufacturer instruction and will be placed in pulp chamber and over pulpal canal orifices for at least 1 mm. The light cure glass inomor is also mixed according to manufacturer instruction and is places over the A or B material and cured for 40 minutes. The treated tooth will be restored with a stainless steel crown or amalgam filling material.

Eligibility criteria: Inclusion Criteria:

* Vital pulp exposure of teeth with caries or trauma
* No clinical signs \& symptoms like pain,inflammation
* No radiographic signs \& symptoms like: internal resorption,external resorption, furcation involvement,pulp canal obliteration.
* The restorable tooth
* No dental treatment contraindication

Exclusion Criteria:

* Systemic diseases
* Existence of pain,inflammation or sinus tract
* No patient compliance

Primary outcomes:
measure: Clinical features and radiographic examination
timeFrame: 6 monthes and one year
Secondary outcomes:
Other outcomes:
Locations:
city: Tehran
country: Iran, Islamic Republic of
facility: Saheed Behesti University for Medical sciences
Study officials:
affiliation: Saheed Behesti University for Medical sciences
name: Fatemeh Shekarchi, student
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT01963156: Synchronization to Improve Non-Adherence to Cardiovascular Medications
Official title: Synchronization to Improve Non-Adherence to Cardiovascular Medications (SyNCMed)
Study type: INTERVENTIONAL
Overall status: TERMINATED
Phase: NA
Conditions: Chronic Disease
Cardiovascular Disease
Diabetes Mellitus
Keywords: Prescription synchronization
Cardiovascular disease
Medication adherence
Randomized controlled trial
Chronic disease
Pharmacy benefit design
Quality improvement
Lead sponsor: Brigham and Women's Hospital
Sponsor class: OTHER
Collaborators: name: CVS Caremark
First posted: 2013-10-16
Enrollment: 3675
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: HEALTH_SERVICES_RESEARCH

Brief summary: The aim of this study is to evaluate if synchronizing when patients with diabetes and/or coronary artery disease fill their prescriptions improves long-term adherence to these medications.


Eligibility criteria: We will enroll patients 18 years of age and older who within 6 months of study enrollment have filled ≥ 2 medications intended for long-term use (i.e. maintenance medications) by mail order at CVS Caremark. At least 1 of these 2 medications of must be for the treatment of diabetes or cardiovascular disease. In addition, these medications must be delivered on two or more unique delivery dates, there must be at least one refill remaining for all eligible medications and either all or none of their prescriptions must be enrolled in the ReadyFill@Mail program (see Intervention Description for details).

Primary outcomes:
measure: Medication adherence
timeFrame: 12 months
Secondary outcomes:
measure: Full adherence to medications for the treatment of diabetes or cardiovascular disease
timeFrame: 12 months
Other outcomes:
measure: Rates of de-synchronization
timeFrame: 12 months
Locations:
city: Woonsocket
country: United States
facility: CVS Caremark
state: Rhode Island
Study officials:
affiliation: Brigham and Women's Hospital/Harvard Medical School
name: Niteesh K Choudhry, MD, PhD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT02752256: Thrombolytic Care During Inter-hospital Transfer
Official title: Quality and Effectiveness of Thrombolytic Care During Inter-hospital Transfer ("Drip-Ship") With Air Ambulance Services
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Stroke
Keywords: tissue plasminogen activator
Lead sponsor: University of Iowa
Sponsor class: OTHER
First posted: 2016-04-26
Enrollment: 76
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: All acute ischemic stroke patients who receive rtPA and transferred to our institution via our air ambulance service or present directly to our ED

Brief summary: Evaluation of ischemic stroke patients receiving tissue plasminogen activator (rtPA) during air ambulance transfer

Detailed description: The purpose of our study is to evaluate the effect of air ambulance transport on patients presenting with an ischemic stroke and receive tissue plasminogen activator (rtPA). Primary outcome will be the evaluation of air ambulance transfer and if it leads to protocol violations or significant delays in therapy. Protocol violations include inaccurate dosing or preparation at the outside hospital, uncontrolled blood pressure before and during the flight, unnecessary medication administration before and during the flight and adverse events (intracranial bleeding, allergic reaction) associated with transfer process. Additional evaluation will include the effects of vibration of the air ambulance and its effects on the lytic activity of rtPA. rtPA is not supposed to be significantly agitated after it is prepared in solution and there is significant vibration and agitation during air ambulance transfer.

Eligibility criteria: Inclusion Criteria:

* Patients who received tissue plasminogen activator for acute ischemic stroke
* presented directly to comprehensive stroke center or were transferred by our air ambulance service

Exclusion Criteria:

* Transferred by another air ambulance service or ground ambulance

Primary outcomes:
measure: Percentage of Participants With a rtPA Protocol Violation
timeFrame: 24 hours
Secondary outcomes:
measure: Average Time to rtPA
timeFrame: 24 hours
Other outcomes:
Locations:
city: Iowa City
country: United States
facility: University of Iowa Hospitals and Clinics
state: Iowa
Study officials:
References:
citation: Faine BA, Dayal S, Kumar R, Lentz SR, Leira EC. Helicopter "Drip and Ship" Flights Do Not Alter the Pharmacological Integrity of rtPA. J Stroke Cerebrovasc Dis. 2018 Oct;27(10):2720-2724. doi: 10.1016/j.jstrokecerebrovasdis.2018.05.049. Epub 2018 Jul 20.
Clinical trial NCT00144456: A New Active Vitamin D, ED-71 for Osteoporosis
Official title: A Prospective, Randomized, Double-blind Study to Compare the Effect of ED-71 With That of Alfacalcidol on Fracture Incidence in Osteoporotic Patients
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE3
Conditions: Osteoporosis
Lead sponsor: Chugai Pharmaceutical
Sponsor class: INDUSTRY
First posted: 2005-09-05
Enrollment: 1056
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: A prospective, randomized, double-blind study to compare the effect of ED-71 with that of alfacalcidol on fracture incidence


Eligibility criteria: Inclusion Criteria:

* Osteoporotic patients who meet any of the following condition:

  1. with at least one fragility fracture,
  2. above 70 year-old with bone mineral density below 70% young adult mean,
  3. with bone mineral density below 60% young adult mean
* Women three years or more after menopause or men

Exclusion Criteria:

* Current disorders such as primary hyperparathyroidism, Cushing's syndrome,gonadal insufficiency, poorly controlled diabetes mellitus or other causes of secondary osteoporosis
* A history or suspicion of active urolithiasis at any time
* Use of bisphosphonates in the past 12 months
* Use of medications known to affect bone in the past 2 months
* Abnormal serum calcium, urinary calcium, serum creatinine or liver function tests

Primary outcomes:
measure: Incidences of vertebral fracture
timeFrame: throughout study
Secondary outcomes:
measure: Changes of Lumbar Spine and total hip bone mineral density
timeFrame: throughout study
Other outcomes:
Locations:
Study officials:
affiliation: Department of Medicine and Bioregulatory Sciences, Universitof Tokushima Graduate School of Health Bioscience
name: Toshio Matsumoto, MD
role: PRINCIPAL_INVESTIGATOR
References:
citation: Shiraki M, Saito H, Matsumoto T. Eldecalcitol normalizes bone turnover markers regardless of their pre-treatment levels. Curr Med Res Opin. 2012 Sep;28(9):1547-52. doi: 10.1185/03007995.2012.712506. Epub 2012 Aug 23.
citation: Matsumoto T, Ito M, Hayashi Y, Hirota T, Tanigawara Y, Sone T, Fukunaga M, Shiraki M, Nakamura T. A new active vitamin D3 analog, eldecalcitol, prevents the risk of osteoporotic fractures--a randomized, active comparator, double-blind study. Bone. 2011 Oct;49(4):605-12. doi: 10.1016/j.bone.2011.07.011. Epub 2011 Jul 19.
Clinical trial NCT02038556: Exploring the Outcomes and Financial Impact of a CBT-I Group Program Provided by Registered Nurses for Adults With Insomnia
Official title: Exploring the Outcomes and Financial Impact of a CBT-I Group Program Provided by Registered Nurses for Adults With Insomnia
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Insomnia
Lead sponsor: Mayo Clinic
Sponsor class: OTHER
First posted: 2014-01-16
Enrollment: 60
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NON_RANDOMIZED
Intervention model: SINGLE_GROUP
Primary purpose: TREATMENT

Brief summary: The purpose of this pilot study is to evaluate our RN CBT-I program outcomes and determine utility of this program as a high-value care model targeted specifically to our sleep center patient population.

Hypothesis: PIRS will improve from baseline to 2 month follow up


Eligibility criteria: * Able to speak english
* Referred to Mayo Center for Sleep medicine Cognitive behaviorial therapy program for insomnia
* no dementia

Primary outcomes:
measure: Pittsburg insomnia rating scale
timeFrame: up to 2 months
Secondary outcomes:
Other outcomes:
Locations:
city: Rochester
country: United States
facility: Mayo Clinic in Rochester
state: Minnesota
city: Rochester
country: United States
facility: Mayo Clinic
state: Minnesota
Study officials:
affiliation: Mayo Clinic
name: Wendy Moore, RN
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT04758156: Comparison Between a 1L of Polyethylene Glycol+Ascorbic Acid as a Split Dose Bowel Preparation for Colonoscopy
Official title: Comparison Between a 1L of Polyethylene Glycol+Ascorbic Acid as a Split Dose Bowel Preparation for Colonoscopy: Prospective, Randomized, Parallel, Multi-center Trial
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: PHASE4
Conditions: Colon Adenoma
Colonic Polyp
Lead sponsor: Seoul National University Hospital
Sponsor class: OTHER
First posted: 2021-02-17
Enrollment: 200
Sex: ALL
Minimum age (years): 20
Maximum age (years): 75
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: OTHER

Brief summary: Comparison between a 1L of polyethylene glycol+ascorbic acid as a split dose and oral sulfate solution bowel preparation for colonoscopy

study design: prospective, randomized, parallel, multi-center trial in 3 hospitals in Korea ( Seoul National University hospital, Seoul National University Bundang hospital, Seoul Metropolitan Government-Seoul National University )

patient inclusion criteria

- aged 20-75 adults (out-clinic patients) scheduled for colonoscopy for any indication within the normal process of care


Eligibility criteria: Inclusion Criteria:

* Adult out clinic patients scheduled for colonoscopy for any indication within the normal process of care

Exclusion Criteria:

* previous history of significant gastrointestinal surgeries (except for appendectomy)
* known or clinically suspicious Inflammatory bowel disease patients
* known or suspected ileus/ GI obstruction
* previous history of major cancer or currently on treating cancer
* Major cardiovascular disease, respiratory disease, liver, hematologic diseases with complication
* severe cognitive impairment / dementia / confusion state
* past history within the last 12 months or current episode of severe constipation severe constipation
* Regular use of laxatives or colon motility-altering drugs (i. e. more than 2 - 3 times per week) in the last 28 days prior to screening and/or laxative use within 72 hours prior to administration of the preparation)
* women who are pregnant or lactating
* known phenylketonuria, glucose-6-phosphate dehydrogenase deficiency
* those who were allergic to any preparation components.
* those who, in the opinion of the investigator, should not be included in the study for any reason

Primary outcomes:
measure: Boston Bowel Preparation Scale (BBPS)
timeFrame: at the time of colonoscopy procedure
Secondary outcomes:
measure: questionnaire gathered for Tolerability, compliance, satisfaction
timeFrame: on the 1 day of colonoscopy via questionnaire
Other outcomes:
Locations:
city: Seoul
country: Korea, Republic of
facility: Seoul national university hospital
Study officials:
affiliation: Seoul National University Hospital
name: Jong Pil Im, MD, PhD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT01606956: The Comparison of Two Different Methods of Partial Inflation of Cuff for Facile Insertion of Laryngeal Mask Airway in Adult Patients
Official title: The Comparison of Two Different Methods of Partial Inflation of Cuff for Facile Insertion of Laryngeal Mask Airway in Adult Patients
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: General Anesthesia
Lead sponsor: Yonsei University
Sponsor class: OTHER
First posted: 2012-05-28
Enrollment: 80
Sex: ALL
Minimum age (years): 20
Maximum age (years): 70
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL

Brief summary: Partial cuff inflation before insertion is generally used for laryngeal mask airway insertion in adult patients. However, it is not proven how much the cuff should be inflated. The aim of this study is to compare efficacy between the method using the resting volume and the method using half the maximum volume for partial cuff inflation.


Eligibility criteria: Inclusion Criteria:

* adult patients (20-70 years of age) scheduled for elective surgery undergoing general anesthesia using LMA-classic size 3-5

Exclusion Criteria:

* patients with an abnormal airway,
* patients with reactive airway disease,
* patients with gastroesophageal reflux disease,
* patients with chronic respiratory disease,
* or a history of an upper respiratory tract infection

Primary outcomes:
measure: The intra-cuff pressure
timeFrame: approximately 5 to 10 minutes after insertion of LMA.
Secondary outcomes:
measure: leak volume
timeFrame: approximately 5 to 10 minutes after insertion of LMA.
Other outcomes:
Locations:
city: Seoul
country: Korea, Republic of
facility: Severance hospital
Study officials:
References:
citation: Al-Shaikh B, George William M, Van Zundert AA. Using atmospheric pressure to inflate the cuff of the Portex Laryngeal Mask. Anaesthesia. 2005 Mar;60(3):296-7. doi: 10.1111/j.1365-2044.2005.04135.x. No abstract available.
citation: Kim MS, Lee JR, Shin YS, Chung JW, Lee KH, Ahn KR. Comparison of 2 cuff inflation methods of laryngeal mask airway Classic for safe use without cuff manometer in adults. Am J Emerg Med. 2014 Mar;32(3):237-42. doi: 10.1016/j.ajem.2013.11.029. Epub 2013 Nov 21.
Clinical trial NCT05395156: EFFECT OF TENS ON ACUPOINTS IN PREMENSTRUAL SYNDROME
Official title: EFFECT OF TENS ON ACUPOINTS IN PREMENSTRUAL SYNDROME
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Premenstrual Pain
Lead sponsor: Cairo University
Sponsor class: OTHER
First posted: 2022-05-27
Enrollment: 50
Sex: FEMALE
Minimum age (years): 18
Maximum age (years): 25
Standard ages: ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: These will be no effect of transcutaneous electrical acupoint stimulation on premenstrual syndrome Does transcutaneous electrical acupoint stimulation affect premenstrual syndrome (PMS)?

Detailed description: Premenstrual syndrome is a collection of emotional, physiological, and behavioral symptoms that develop around the end of the luteal phase and fade away with or after menstruation Due to limited evidence on the efficacy of sustained progesterone and the side effects of antidepressant and anxiolytics, in some cases, alternative therapies are recommended for patients with PMS TEAS may be more effective than other forms of transcutaneous electrical nerve stimulation (TENS) in modulating brain activity because acupoint areas contain relatively denser neural and neuroactive components than non-acupoint areas TEAS has been reported to have similar efficacy as acupuncture, electrical acupuncture, and TENS

Eligibility criteria: Inclusion Criteria:

* Their age will range from 18 to 25 years.
* The regularity of menstrual cycle is 28-35 days.
* All of them suffering from moderate and sever PMS.
* All participants are virgin.
* Their BMI will range from 25-30 kg\\m2.

Exclusion Criteria:

* Any pathological findings in the pelvic cavity as PCO, Endometriosis and pelvic inflammatory disease.
* Any history of gynecological intervention.
* Have any condition impedes the use of electrotherapy.
* Receiving sedatives or any medical treatment.
* Having irregular menstruation.

Primary outcomes:
measure: pain severity
timeFrame: Up to 3 monthes
measure: premenstrual syndrome severity
timeFrame: up to 3 monthes
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
References: