Clinical trial NCT03443193: Periodization of Exercise Training in Patients With Coronary Heart Disease.
Official title: The Effects of Periodization Training on Physiological Parameters, Cerebral Oxygenation, Cognitive Functions and Cardiac Remodelling in Coronary Patients.
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Coronary Heart Disease
Healthy Control
Keywords: aerobic exercise training
periodization
cerebral oxygenation and perfusion
cognition
Lead sponsor: Montreal Heart Institute
Sponsor class: OTHER
First posted: 2018-02-23
Enrollment: 70
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The research project includes two components that assess exercise physiology parameters, cerebrovascular reserve, cognitive functions and cardiac function in coronary heart disease patients at rest, during an acute exercise, and after two different periodized training programs.


Eligibility criteria: Inclusion Criteria for patients with coronary heart disease:

* Major
* Adequate physical and mental capacities
* Autonomy in daily activities
* Documented coronary artery disease
* Stable or recent coronary artery disease

Exclusion Criteria for patients with coronary heart disease:

* Inability to complete the consent form
* Acute coronary syndrome \< 3 months
* Heart failure
* Ejection fraction of the left ventricle \<40%
* Coronary artery disease non revascularisable including left main coronary stenosis
* Waiting for a bridging of the coronary artery
* Chronic atrial fibrillation
* Malignant arrhythmias during exercise
* Restriction to non cardiopulmonary exercise
* Severe intolerance to exercise

Primary outcomes:
measure: Maximal oxygen uptake (VO2peak) with gas exchange
timeFrame: At baseline and following 12 weeks exercise training intervention
Secondary outcomes:
measure: Cerebral hemodynamics
timeFrame: At baseline and following 12 weeks exercise training intervention
measure: Cognitive functions at rest by a by standard pen-paper battery test
timeFrame: At baseline and following 12 weeks exercise training intervention
measure: Cardiac hemodynamics
timeFrame: At baseline and following 12 weeks exercise training intervention
measure: Standard echocardiographic parameter of left and right ventricular strain
timeFrame: At baseline and following 12 weeks exercise training intervention
Other outcomes:
Locations:
city: Montréal
country: Canada
facility: Cardiovascular prevention and rehabilitation center
state: Quebec
Study officials:
References:
citation: Boidin M, David LP, Trachsel LD, Gayda M, Tremblay J, Lalonge J, Juneau M, Nigam A, Henri C. Impact of 2 different aerobic periodization training protocols on left ventricular function in patients with stable coronary artery disease: an exploratory study. Appl Physiol Nutr Metab. 2021 May;46(5):436-442. doi: 10.1139/apnm-2020-0423. Epub 2020 Oct 27.
citation: Trachsel LD, Boidin M, Henri C, Fortier A, Lalonge J, Juneau M, Nigam A, Gayda M. Women and men with coronary heart disease respond similarly to different aerobic exercise training modalities: a pooled analysis of prospective randomized trials. Appl Physiol Nutr Metab. 2021 May;46(5):417-425. doi: 10.1139/apnm-2020-0650. Epub 2020 Oct 23.