Clinical trial NCT00051207: Therapy for Depression With Co-occurring Panic or Anxiety Symptoms
Official title: Interpersonal Psychotherapy for Depression With Co-occurring Panic and Anxiety Symptoms (IPT-PS)
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE1
PHASE2
Conditions: Depression
Anxiety Disorders
Panic Disorder
Keywords: Mood Disorders
Psychotherapy
Comorbidity
Lead sponsor: University of Pittsburgh
Sponsor class: OTHER
First posted: 2003-01-08
Enrollment: 36
Sex: ALL
Minimum age (years): 18
Maximum age (years): 60
Standard ages: ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: This 6-month study, with a 3-month follow up period, will compare the effectiveness of new and traditional psychotherapies for depression with panic or anxiety symptoms.

Detailed description: Many depressed patients also experience significant symptoms of panic or anxiety. This study will compare the effectiveness of a new therapy called interpersonal psychotherapy for depression with panic or anxiety symptoms (IPT-PS) with that of traditional interpersonal psychotherapy for depression (IPT).

Participants are randomly assigned to receive up to 24 weeks of treatment with either IPT-PS or traditional IPT. Improvements in interpersonal functioning, quality of life, and symptoms of depression and anxiety will be assessed at the end of therapy and at a 3-month follow-up.

Eligibility criteria: Inclusion Criteria:

* DSM-IV diagnosis of major depression with co-existing panic or anxiety symptoms.

Exclusion Criteria:

* History of manic episode(s). Patients who have had hypomanic episodes in the past will be accepted into the study, provided they meet other admission criteria and are not presenting in a current hypomanic or mixed episode.
* History of schizophrenia or schizoaffective disorder.
* Organic affective syndrome.
* Unspecified functional psychosis.
* Anorexia nervosa or bulimia nervosa. Patients meeting criteria for an eating disorder not otherwise specified will not be excluded.
* Chronic drug or alcohol abuse/dependence within the past 2 years. Patients with abuse related to episodes will not be excluded.
* DSM-IV criteria for borderline or antisocial personality disorder. Patients who meet criteria for other Axis II disorders will not be excluded.
* Inpatient treatment due to suicide risk or psychotic symptoms.
* Index episode secondary to the effect of medically prescribed drugs.
* Significant or untreated medical illness, including cardiovascular disorder, renal or liver disease, epilepsy, untreated hypertension, or unstabilized endocrine disease.
* Medical illness that would interfere with the best treatment strategy for the potential participant.
* Current treatment with an antidepressant. Patients on a stable dose of anxiolytics for at least 3 months prior to study participation who are able to maintain this dosage throughout the study will not be excluded.
* Pregnant and breast-feeding women will be accepted into the study, but will not be prescribed adjunctive medications.

Primary outcomes:
Secondary outcomes:
Other outcomes:
Locations:
city: Pittsburgh
country: United States
facility: Western Psychiatric Institute and Clinic - Depression and Manic Depression Program
state: Pennsylvania
Study officials:
References: