Clinical trial NCT03003988: Physiological Effects of Creatine Supplementation in Active Males
Official title: Effects of 28 Days of Different Forms of Creatine Supplementation on Muscle Creatine, Body Composition and Exercise Performance in Recreationally Active Males
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Dietary Supplementation
Lead sponsor: Texas A&M University
Sponsor class: OTHER
Collaborators: name: Nutrabolt
First posted: 2016-12-28
Enrollment: 48
Sex: MALE
Minimum age (years): 18
Maximum age (years): 40
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: HEALTH_SERVICES_RESEARCH

Brief summary: This study was designed to examine how different forms of creatine impact active males.

Detailed description: This study examined the effects of different formulations of creatine nitrate on muscle creatine content, body composition, anaerobic exercise capacity, bench press performance and clinical chemistry panels in recreationally active males.

Eligibility criteria: Inclusion Criteria:

* participants are apparently healthy and recreationally active males between the ages of 18 and 40;
* participants will need to have at least six months immediate prior history of resistance training on the bench press and leg press or squat;

Exclusion Criteria:

* participants have a history of treatment for metabolic disease (i.e., diabetes), hypertension, hypotension, thyroid disease, arrhythmias and/or cardiovascular disease;
* participants are currently using prescription medications;
* participants have a history of smoking;
* participants drink excessively (i.e., 12 drinks per week or more);
* participants have a recent history of creatine supplementation within six weeks of the start of supplementation;

Primary outcomes:
measure: Effects of 28 Days of Different Forms of Creatine Supplementation on Body Water
timeFrame: 28 Days
measure: Effects of 28 Days of Different Forms of Creatine Supplementation on Body Composition
timeFrame: 28 Days
measure: Effects of 28 Days of Different Forms of Creatine Supplementation on intramuscular creatine
timeFrame: 28 Days
measure: Effects of 28 Days of Different Forms of Creatine Supplementation on intramuscular phosphocreatine
timeFrame: 28 Days
measure: Effects of 28 Days of Different Forms of Creatine Supplementation on intramuscular ATP
timeFrame: 28 Days
measure: Effects of 28 Days of Different Forms of Creatine Supplementation on muscular strength
timeFrame: 28 Days
measure: Effects of 28 Days of Different Forms of Creatine Supplementation on muscular endurance
timeFrame: 28 Days
measure: Effects of 28 Days of Different Forms of Creatine Supplementation on anaerobic capacity
timeFrame: 28 Days
Secondary outcomes:
measure: Effects of 28 Days of Different Forms of Creatine Supplementation on training volume (weight lifted x number of repetitions x number of sets)
timeFrame: 28 Days
measure: Effects of 28 Days of Different Forms of Creatine Supplementation on self-reported side effects
timeFrame: 28 Days
measure: Effects of 28 Days of Different Forms of Creatine Supplementation on blood
timeFrame: 28 Days
Other outcomes:
Locations:
Study officials:
affiliation: Texas A&M University
name: Richard B Kreider, PhD
role: PRINCIPAL_INVESTIGATOR
References: