Clinical trial NCT03708952: Lifestyle and Dietary Pattern in Relation to Precursor Lesions of Colorectal Cancer and Cardiometabolic Diseases
Official title: Lifestyle and Dietary Pattern in Relation to Precursor Lesions of Colorectal Cancer and Cardiometabolic Diseases Among High-risk Populations in Lanxi, China
Study type: OBSERVATIONAL
Overall status: ACTIVE_NOT_RECRUITING
Conditions: Polyps
Cardiovascular Diseases
Keywords: Dietary factors
Precursor lesions of colorectal cancer
Lifestyle
Polyps
Cardiovascular Diseases
Lead sponsor: Zhejiang University
Sponsor class: OTHER
Collaborators: name: Lanxi Hospital of Traditional Chinese Medicine
name: Lanxi Red Cross Hospital
First posted: 2018-10-17
Enrollment: 25000
Sex: ALL
Minimum age (years): 45
Maximum age (years): 74
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: Subjects are eligible residents from 16 towns and villages of Jinhua, China.

Brief summary: The association between lifestyle and dietary patterns with precursor lesions of colorectal cancer and cardiometabolic diseases is still unclear. This study is conducted in Jinhua, a city with a high prevalence of colorectal cancer in China, to assess the relationship between lifestyle and dietary factors with precursor lesions of colorectal cancer and cardiometabolic diseases.

Detailed description: Investigations of lifestyle and dietary factors in relation to precursor lesions of colorectal cancer and cardiometabolic diseases are limited in China. The investigators aim to collect the basic characteristics of participants at baseline, including sex, age, smoking, exercise, marriage, education level, dietary factors and so on, to assess the associations between lifestyle and dietary factors with precursor lesions of colorectal cancer and cardiometabolic diseases. This large cohort - the Lanxi Pre-colorectal Cancer Cohort (LP3C) also included several subcohorts consisting of patients with CVD, diabetes, hypertension, metabolic syndrome, obese/overweight or fatty liver disease. Results from this study will be valuable for colorectal cancer and cardiometabolic disease prevention in China.

Eligibility criteria: Inclusion Criteria:

* Subject aged ≥45 and ≤74 years old
* Subject has complete data on diet and follow-up time

Exclusion Criteria:

* Colorectal cancer
* Severe intestines problems

Primary outcomes:
measure: Numbers of participants with polyps
timeFrame: From entry into the study (baseline:2018-2022) until 2028
Secondary outcomes:
measure: Numbers of participants with different subtypes of polyps
timeFrame: From entry into the study (baseline:2018-2022) until 2028
measure: Numbers of participants with cardiometabolic diseases
timeFrame: From entry into the study (baseline:2018-2022) until 2028
Other outcomes:
measure: Numbers of participants died
timeFrame: From entry into the study (baseline:2018-2022) until 2028
Locations:
city: Jinhua
country: China
facility: Lanxi Hospital of Traditional Chinese Medicine
state: Zhejiang
city: Lanxi
country: China
facility: Lanxi Red Cross Hospital
state: Zhejiang
Study officials:
affiliation: Lanxi Red Cross Hospital
name: Weifang Zheng, MD
role: PRINCIPAL_INVESTIGATOR
affiliation: Zhejiang University
name: Jingjing Jiao
role: PRINCIPAL_INVESTIGATOR
affiliation: Zhejiang University
name: Pan Zhuang
role: PRINCIPAL_INVESTIGATOR
References: