Clinical trial NCT06075732: ACTIVATE in Public Housing
Official title: Academic-Community Team for Improving Vaccine Acceptability and Targeted Engagement: Public Housing
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Pneumonia
Influenza
Varicella Zoster
Meningitis
COVID-19
Vaccine Hesitancy
Lead sponsor: Charles Drew University of Medicine and Science
Sponsor class: OTHER
First posted: 2023-10-10
Enrollment: 400
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: SUPPORTIVE_CARE

Brief summary: This multilevel, multidisciplinary, theoretically based, culturally sensitive, community-engaged intervention sets out to mitigate uptake barriers and non-adherence to vaccination schedules as recommended by the CDC and increase influenza, meningitis, pneumonia, VZV, and COVID-19 vaccine rates among under-resourced African American and Latino public housing residents in South Los Angeles.

Detailed description: Vaccinations are critical for preventing infectious diseases such as influenza, meningitis, pneumonia, varicella zoster virus (VZV), and COVID-19. Despite increasing national distribution and promotion of routine recommendations for adult vaccination, coverage remains low, with historically lower uptake among racial and ethnic minorities. This is compounded by higher levels of vaccine hesitancy, which may be attributed to a myriad of issues, including worsening social determinants, medical mistrust, and lack of access to health services. Specifically, African American and Latino public housing residents may benefit from public health campaigns and vaccination initiatives to support high vaccine uptake and confidence. This R01 proposal seeks to expand on a proven, multilevel, multidisciplinary, theoretically based, culturally sensitive, community-engaged intervention by expanding the Academic-Community Team for Improving Vaccine Acceptability and Targeted Engagement (ACTIVATE) program. Guided by a fusion of the Social-Ecological framework (SEM) and the Practical, Robust Implementation and Sustainability Model (PRISM), the ACTIVATE program is inclusive of health factors on the individual, interpersonal, community, and societal level and elements for successful implementation. Led by leadership triads of public housing resident leaders, nurse practitioner students, and public health students, the ACTIVATE program centers on mitigating uptake barriers and non-adherence to vaccination schedules as recommended by the CDC and to increase influenza, meningitis, pneumonia, VZV, and COVID-19 vaccine rates among under-resourced AA and Latino adults in South LA.

Eligibility criteria: Aim 3:

Inclusion Criteria:

* identify as Latinx or African American
* age 18 or older
* reside in one of the six collaborating public housing area
* Speak either English or Spanish
* Report vaccine hesitancy

Exclusion Criteria:

* Not a resident at one of the collaborating public housing areas
* Does not self-identify as African American or Latinx
* Age 17 and younger
* Unable to speak either English or Spanish
* Received all recommended vaccines for Influenza, Pneumonia, Meningitis, VZV, and COVID-19
* No reporting of vaccine hesitancy

Primary outcomes:
measure: Prevalence of vaccination uptake for Influenza, Pneumonia, Meningitis, VZV, and COVID-19 using Vaccination History Self Report
timeFrame: Intervention: 8 months; Follow-up Point: 3- and 9-months post-intervention
Secondary outcomes:
measure: Percentage of Participants Achieving Decreased Vaccine Hesitancy Levels of Influenza, Pneumonia, Meningitis, VZV, and COVID-19 vaccine Using the NIH Toolbox Surveys on COVID-19
timeFrame: Intervention: 8 months; Follow-up Point: 3- and 9-months post-intervention
measure: Percentage of Participants Achieving Increased Level of Behavior Change toward COVID-19 Vaccination Using the NIH Toolbox Surveys on Influenza, Pneumonia, Meningitis, VZV, and COVID-19
timeFrame: Intervention: 8 months; Follow-up Point: 3- and 9-months post-intervention
Other outcomes:
Locations:
city: Los Angeles
country: United States
facility: Charles R. Drew University of Medicine & Science
state: California
Study officials:
References: