Clinical trial NCT05108792: Continuous Deep Sedation Until Death
Official title: Continuous Deep Sedation Until Death Following a Decision to Limit or Stop Treatment in Intensive Care and in Continuous Surveillance Units
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Terminal Care
Keywords: Limit or Stop Treatment in Intensive Care
Continuous deep sedation (CDS)
Continuous deep sedation until death (CDSUD)
Lead sponsor: Société Française d'Anesthésie et de Réanimation
Sponsor class: OTHER
First posted: 2021-11-05
Enrollment: 585
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: RETROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: Adult patients at the time of death (\>18years) Died in intensive care or in continuing care unit following a decision to limit or stop therapeutics

Brief summary: This research is a descriptive observational study conducted in multicenter (intensive care and continuing care units) in France. All data collected is part of the patient record. The main objective is to describe the end-of-life sedative practices following a decision to limit or stop therapy in intensive care unit and continuing care unit.

Detailed description: All participating sites will include last 10 consecutive major patients deceased following a decision to limit or stop therapeutics. The study include only data from patients died before January 1, 2020. In the case report form the following information will be entered:

* the characteristics of the unit of intensive care or continuing care unit.
* Patient Characteristics
* Characteristics of sedative practices

Eligibility criteria: Inclusion Criteria:

* Adult patients at the time of death (\>18years)
* Died in intensive care or in continuing care unit
* Patient died before January 1st, 2020.
* Patients deceased following a decision to limit or stop therapeutics

Exclusion Criteria:

* Patients who died of brain death or unexpected cardiac arrest at death of unsuccessful cardiopulmonary resuscitation
* Patient who expressed during his lifetime his opposition to the use of his data for scientific research

Primary outcomes:
measure: Description of end-of-life sedative practices
timeFrame: after patient death (before january 1st 2020)
Secondary outcomes:
Other outcomes:
Locations:
city: Amiens
country: France
facility: CHU Amiens
city: Angers
country: France
facility: CHU Angers
city: Arras
country: France
facility: CH Arras
city: Ars-Laquenexy
country: France
facility: CHR Metz Thionville
city: Aurillac
country: France
facility: CH Henri Mondor d'Aurillac
city: Besançon
country: France
facility: CHU Jean Minjoz
city: Château-Thierry
country: France
facility: Centre Hospitalier de Chateau Thierry
city: Clamart
country: France
facility: Hôpital d'Instruction des Armées Percy
city: Clermont-Ferrand
country: France
facility: CHU Clermont-Ferrand - Site de Gabriel Montpied - Neuroréanimation
city: Clermont-Ferrand
country: France
facility: CHU Clermont-Ferrand - Site de Gabriel Montpied - Réa médico chir
city: Clichy
country: France
facility: Hôpital Beaujon - Réa hépato digestive
city: Clichy
country: France
facility: Hôpital Beaujon - Réa neuro chir
city: Dax
country: France
facility: CH de DAX
city: Grenoble
country: France
facility: CHU de Grenoble - Hôpital A Michallon
city: Jossigny
country: France
facility: Hôpital privé de Marne la Vallée
city: La Rochelle
country: France
facility: Groupe Hospitalier LITTORAL ATLANTIQUE
city: Laon
country: France
facility: Centre Hospitalier de Laon - Réanimation Polyvalente
city: Le Chesnay
country: France
facility: CH de Versailles - André Mignot
city: Le Kremlin-Bicêtre
country: France
facility: Hôpital Bicêtre
city: Lille
country: France
facility: CHRU de Lille - Réa Neurochirurgicale
city: Lille
country: France
facility: CHRU de Lille - service de déchocage et de soins intensifs - Urgence
city: Lille
country: France
facility: CHRU de Lille- Hôpital Huriez
city: Marseille
country: France
facility: CHU la Timone 2 - Pôle GEST - RUSH
city: Marseille
country: France
facility: Hôpital Nord Aphm
city: Mont-de-Marsan
country: France
facility: CH Mont de Marsan
city: Montpellier
country: France
facility: CHU de Montpellier - Hopital Gui de Chauliac - Réa médicale
city: Montpellier
country: France
facility: CHU de Montpellier - Hopital Gui de Chauliac
city: Montpellier
country: France
facility: CHU MONTPELLIER - Hôpital Arnaud de Villeneuve
city: Montpellier
country: France
facility: CHU Montpellier - Hôpital Lapeyronie
city: Montélimar
country: France
facility: Centre Hospitalier de Montélimar
city: Mulhouse
country: France
facility: Groupe hospitalier de la région de Mulhouse et Sud-Alsace _ GHRMSA Mulhouse
city: Nancy
country: France
facility: CHRU de NANCY
city: Nantes
country: France
facility: CHU Nantes, Hôtel-Dieu
city: Nice
country: France
facility: Hôpital Pasteur 2 - CHU de Nice
city: Nice
country: France
facility: Hôpital Privé Gériatrique Les Sources- Nice
city: Nouméa
country: France
facility: Centre Hospitalier territorial de Nouméa en Nouvelle Calédonie
city: Nîmes
country: France
facility: CHU de Nimes
city: Orléans
country: France
facility: Centre Hospitalier d'Orléans
city: Paris
country: France
facility: Centre Hospitalier Sainte-Anne
city: Paris
country: France
facility: CHU Bichat Claude Bernard
city: Paris
country: France
facility: Fondation Ophtalmologique Adolphe de Rothschild
city: Paris
country: France
facility: Hôpital Lariboisière
city: Paris
country: France
facility: Hôpital Pitié-Salpêtrière - Réa neuro chir
city: Paris
country: France
facility: Hôpital Pitié-Salpêtrière - Réanimation Polyvalente
city: Paris
country: France
facility: Hôpital Pitié-Salpêtrière Paris - SSPI
city: Paris
country: France
facility: hôpital Saint Antoine - Paris
city: Poitiers
country: France
facility: CHU de Poitiers
city: Reims
country: France
facility: CHU de Reims
city: Rennes
country: France
facility: CHU de Rennes - Réanimation chirurgicale
city: Rennes
country: France
facility: CHU de Rennes - Réanimation CTCV
city: Romans
country: France
facility: Hôpitaux Drôme Nord - Site de Romans
city: Rouen
country: France
facility: CHU de Rouen
city: Rouen
country: France
facility: CHU Rouen - Réanimation cardiaque chirurgicale
city: Saint-Grégoire
country: France
facility: Centre Hospitalier Privé Saint-Grégoire
city: Strasbourg
country: France
facility: CHRU Strasbourg
city: Toulon
country: France
facility: Hôpital d'Instruction des Armées Sainte Anne
city: Toulouse
country: France
facility: CHU de Toulouse - Hôpital Pierre-Paul
city: Toulouse
country: France
facility: CHU de Toulouse-Rangueil
city: Toulouse
country: France
facility: CHU Rangueil - Toulouse - Réanimation de Néphrologie et Transplantation
city: Toulouse
country: France
facility: Clinique Pasteur
city: Tours
country: France
facility: CHRU Tours, Site Trousseau - Réa chir
city: Tours
country: France
facility: CHRU Tours, Site Trousseau - URTC-B
city: Vannes
country: France
facility: Centre Hospitalier Bretagne Atlantique de Vannes
city: Villejuif
country: France
facility: Gustave Roussy
Study officials:
affiliation: GH Lariboisière-St Louis
name: Matthieu LE DORZE, MD
role: STUDY_CHAIR
References: