Clinical trial NCT04537507: Atrial Fibrillation and Non-obstructive Coronary Lesions
Official title: Is Atrial Fibrillation is Associated With Non-significant Coronary Angiography Findings?
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Fibrillation, Atrial
Coronary Artery Disease
Chronic Kidney Diseases
Keywords: Fibrillation, Atrial
Coronary Artery Disease
Chronic Kidney Disease
Lead sponsor: Medical University of Bialystok
Sponsor class: OTHER
Collaborators: name: I.M. Sechenov First Moscow State Medical University
name: Liverpool Heart and Chest Hospital NHS Foundation Trust
name: Medical University of Gdansk
First posted: 2020-09-03
Enrollment: 8000
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: OTHER
Sampling method: PROBABILITY_SAMPLE
Study population: We conducted a multi-center retrospective study including consecutive patients referred for elective coronary angiography.

Brief summary: Atrial fibrillation (AF) is the most common cardiac arrhythmia associated with excessive risk of ischemic stroke and heart failure as well as reduced life expectancy. On the other hand, chronic coronary syndromes (CCS) remains the main cause of morbidity and mortality in an aging population. Both disease entities share common risk factors such as hypertension, diabetes and obesity The purpose of the study is to investigate the hypothesis indicating lack of significant coronary lesions in AF vs. sinus rhythm (SR) patients.

Detailed description: Atrial fibrillation (AF) and chronic coronary syndromes (CCS) share common risk factors and both disease entities frequently co-exist. Additionally, AF symptoms may mimic CCS. Objectives: To investigate the hypothesis indicating lack of significant coronary lesions in AF vs. sinus rhythm (SR) patients.

The prevalence of CCS in patients with AF varies from 17% to 47% whereas AF in patients with CCS is much less common, ranging from 0.2% to 5.Patients with AF more often have concomitant CCS as compared with sinus rhythm controls. Additionally, AF is more frequently present in patients with either peripheral- or cerebrovascular artery disease than in non-atherosclerotic individuals We conducted a multi-center retrospective study including consecutive patients referred for elective coronary angiography.

Eligibility criteria: Inclusion Criteria:

* Coronary angiography

Exclusion Criteria:

* We excluded patients with acute coronary syndromes (ACS), Tako-tsubo cardiomiopathy and history of ischemic heart disease, as well as those referred for coronary angiography before heart valve surgery. Prior cardiosurgical valve replacement was also the exclusion criterion.

Primary outcomes:
measure: Coronary artery disease
timeFrame: Through study completion, an average of 8 years
Secondary outcomes:
Other outcomes:
Locations:
city: Bialystok
country: Poland
facility: Medical Univeristy of Bialystok
city: Białystok
country: Poland
facility: Department of Cardiology, Medical University of Bialystok, Bialystok, Poland
city: Gdansk
country: Poland
facility: Department of Cardiology and Internal Medicine, Medical University of Gdansk, Gdynia, Poland
city: Moscow
country: Russian Federation
facility: Department of Internal diseases, I.M.Sechenov First Moscow State Medical University, Moscow, Russian Federation
city: Liverpool
country: United Kingdom
facility: iverpool Centre for Cardiovascular Science, University of Liverpool and Liverpool Heart & Chest Hospital, Liverpool, United Kingdom
Study officials:
References:
citation: Tomaszuk-Kazberuk A, Kozinski M, Kuzma L, Bujno E, Lopatowska P, Rogalska E, Dobrzycki S, Sobkowicz B, Lip GYH. Atrial fibrillation is more frequently associated with nonobstructive coronary lesions: the Bialystok Coronary Project. Pol Arch Intern Med. 2020 Dec 22;130(12):1029-1036. doi: 10.20452/pamw.15635. Epub 2020 Oct 5.
citation: Rogalska E, Kuzma L, Wojszel ZB, Kurasz A, Napalkov D, Sokolova A, Tomaszuk-Kazberuk A. Atrial fibrillation is a predictor of nonobstructive coronary artery disease in elective angiography in old age: a cross-sectional study in Poland and Russia. Aging Clin Exp Res. 2022 Jan;34(1):175-183. doi: 10.1007/s40520-021-01895-y. Epub 2021 Jun 11.