Clinical trial NCT05306678: Breaking Sitting and Metabolic Health in Sedentary Overweight and Obese Adults
Official title: Acute Effects of Breaking Prolonged Sitting on Postprandial Glycaemic Response, Incretin Hormones Secretion and Eating Behaviour in Overweight and Obese Adults
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Metabolic Health
Gut Hormones
Energy Balance
Keywords: GLP-1
PYY
Breaking sitting
Energy balance
Postprandial glycaemia
Lead sponsor: National Taiwan Normal University
Sponsor class: OTHER
First posted: 2022-04-01
Enrollment: 13
Sex: ALL
Minimum age (years): 20
Maximum age (years): 45
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: CROSSOVER
Primary purpose: BASIC_SCIENCE

Brief summary: The purpose of this project is to investigate the effects of breaking up prolonged sitting on postprandial metabolic responses, gut hormones secretion and energy balance in sedentary overweight and obese adults.

Detailed description: Two trials are included in this project - Prolonged sitting and Breaking sitting.

In the Prolonged sitting trial, after consuming breakfast, participants sat on a chair for 180 min. After 180 min, lunch was provided. After finishing lunch, participants sat on a chair for another 120 min. In the Breaking sitting trial, after consuming breakfast, participants walked 2 min on a treadmill every 20 minutes for the following 180 min. For the remainder of the time participants sat on the chair. After 180 min, lunch was provided. After finishing lunch, participants continued 2 min of walking every 20 min for the following 120 min. Blood samples were collected in a regular pattern throughout the trials. Energy balance (e.g., energy intake and spontaneous physical activity) was assessed using food diary and an accelerometer until midnight in the trial days once participants left laboratory.

Eligibility criteria: Inclusion Criteria:

* Physical inactive males and females
* Aged between 20 and 45 years
* Overweight and obese healthy adults (waist circumference greater than 90 cm for males and 80 cm for females)
* Weight stable for more than 3 months (no change in weight +/- 3%)
* Non-smoker
* Able to walk comfortably on a treadmill

Exclusion Criteria:

* Personal history of/existing diabetes, cardiovascular disease, metabolic disease or dyslipidaemia
* Waist circumference \< 90 cm for male and \< 80 cm for female
* Taking medications that may influence lipid or carbohydrate metabolism or immune system function
* Unable to take part in exercise for any reason (e.g., injury or disability) or a positive response to any questions on the Physical Activity Readiness questionnaire (PAR-Q)

Primary outcomes:
measure: Gut hormones responses
timeFrame: 320 minutes
Secondary outcomes:
measure: Visual analogue scale (VAS)
timeFrame: 320 minutes
measure: Energy intake
timeFrame: 600 minutes after leaving the labalotory
measure: Physical activity level
timeFrame: 600 minutes after leaving the labalotory
measure: Lipid profile
timeFrame: 320 minutes
measure: Blood pressure
timeFrame: 320 minutes
measure: Computerized cognitive testing
timeFrame: 320 minutes
measure: Incremental area under curve (iAUC) for metabolic health
timeFrame: 320 minutes
Other outcomes:
Locations:
city: Taipei
country: Taiwan
facility: National Taiwan Normal University
Study officials:
affiliation: National Taiwan Normal University
name: Chen, PhD
role: PRINCIPAL_INVESTIGATOR
References: