Clinical trial NCT05296109: Application of 3D MR Neurogram for Intraparotid Facial Nerves Evaluation
Official title: Application of 3D Magnetic Resonance Neurogram Sequences for Evaluation of Intraparotid Facial Nerves in Patients With Parotid Neoplasm
Study type: INTERVENTIONAL
Overall status: RECRUITING
Phase: NA
Conditions: Parotid Neoplasms
Lead sponsor: Chinese University of Hong Kong
Sponsor class: OTHER
First posted: 2022-03-25
Enrollment: 50
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: DIAGNOSTIC

Brief summary: Parotid neoplasm consists of a wide range of benign and malignant lesions, and parotidectomy has been the mainstay for management of these neoplasms. Within the parotid gland there are branches of the intra-parotid facial nerves, which are tiny in calibre and are prone to injury to injury during operation. It has been reported in recent retrospective view that the incidence of temporary and permanent facial nerve injury were 9.2% and 5.2% respectively, the risk of which increased with old age, malignant tumour and revision surgery. Traditional the incidental of facial nerve injury is reduced by intra-operative facial nerve monitoring and surgical magnification, while imaging has limited role in aiding this purpose. However with advancement in MRI technique high resolution three-dimensional sequences (i.e. neurogram sequences) are available for better visualization of branches of facial nerves. The investigators would therefore aim to demonstrate additional efficacy of these techniques and also to compare with conventional 3D post-contrast anatomical imaging studies in the localization and visualization of the facial nerve branches in patients with tumour. With better pre-operative imaging, the investigators hope to reduce the chance of facial nerve injury in these patients.


Eligibility criteria: Inclusion Criteria:

* Consecutive patients with parotid tumour diagnosed on other imaging modalities (such as ultrasonography or computed tomography), with or without cytological diagnosis from fine needle aspiration, will be recruited from the ear, nose and throat specialty clinic.

Exclusion Criteria:

* Patients who are contraindicated to magnetic resonance imaging (such as due to underlying MRI incompatible metallic implants)
* Patient who are contraindicated to MRI contrast agents (such as advanced renal failure or previous severe allergic reaction)
* Patients who cannot cooperate for MRI scanning.
* Patients show are unable to provide informed consent.

Primary outcomes:
measure: visualization of the major branches of the facial nerve on MRI sequences
timeFrame: At MRI scan before therapeutic intervention (operation or radiofrequency ablation)
Secondary outcomes:
measure: Diagnostic value of multi-parametric MRI
timeFrame: At MRI scan before therapeutic intervention (operation or radiofrequency ablation)
Other outcomes:
Locations:
city: Hong Kong
country: Hong Kong
facility: Gerald Choa MRI Center
Study officials:
affiliation: Department of Imaging and Interventional Radiology, Prince of Wales Hospital
name: Ho Sang Leung, MBBS (HK)
role: PRINCIPAL_INVESTIGATOR
affiliation: Department of Imaging and Interventional Radiology, Prince of Wales Hospital
name: Chiu Wing WInnie Chu, MD, FHKCR
role: STUDY_DIRECTOR
References: