Clinical trial NCT02869178: Strain X Cardiopulmonary Test
Official title: Analysis Of Strain Myocardial Associated With The Exercise Tolerance In Patients With Heart Failure Systolic
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Heart Failure
Lead sponsor: Universidade Federal de Pernambuco
Sponsor class: OTHER
First posted: 2016-08-16
Enrollment: 26
Sex: ALL
Minimum age (years): 21
Maximum age (years): 65
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Time perspective: CROSS_SECTIONAL
Sampling method: NON_PROBABILITY_SAMPLE
Study population: The study population consisted of adults 21-65 years diagnosed with HF of all etiologies , in functional class II and III by the New York Heart Association ( NYHA ) , sedentary , of both sexes.

Brief summary: Introduction : Patients with heart failure (HF ) with systolic dysfunction of moderate to severe exhibit significant reduction in the ability to exercise compared to those with mild dysfunction , and have worse prognosis. However, some clinical markers of severity and diagnosis widely used in this population such as ejection fraction (EF) , are not always able to translate the actual degree of cardiac damage as well as their relationship with the cardiorespiratory fitness of these individuals and prognosis .

Objective: To evaluate the ability of the global longitudinal strain ( GLS ) in predicting exercise tolerance in heart failure patients with moderate and significant systolic dysfunction.


Eligibility criteria: Inclusion Criteria:

* moderate and significant systolic dysfunction (LVEF \< 45%) assessed by transthoracic echocardiography recent ( last month before evaluation ) Teichholz method , or when in the presence of contractile deficit target , by the Simpson method.

Exclusion Criteria:

* deformity in the face to prevent the coupling of the mask to perform the CPET ,
* orthopedic and neurological diseases that could make it impossible to perform the tests ,
* patients with psychiatric disorders that restricted them to respond to the questionnaire ,
* HF FC IV or hospitalization in the last three months ,
* angina unstable;
* myocardial infarction or heart surgery up to three months before the survey ;
* FEV1 / FVC \<70 % predicted characterizing obstructive respiratory disorder .

Primary outcomes:
measure: Echocardiography for obtaining the "strain "
timeFrame: 1 day
Secondary outcomes:
measure: Cardiopulmonary Test
timeFrame: 1 day
Other outcomes:
Locations:
city: Recife
country: Brazil
facility: Universidade Federal de Pernmabuco
state: PE
Study officials:
References:
citation: Becker M, Hoffmann R, Kuhl HP, Grawe H, Katoh M, Kramann R, Bucker A, Hanrath P, Heussen N. Analysis of myocardial deformation based on ultrasonic pixel tracking to determine transmurality in chronic myocardial infarction. Eur Heart J. 2006 Nov;27(21):2560-6. doi: 10.1093/eurheartj/ehl288. Epub 2006 Oct 11.
citation: Belohlavek M, Pislaru C, Bae RY, Greenleaf JF, Seward JB. Real-time strain rate echocardiographic imaging: temporal and spatial analysis of postsystolic compression in acutely ischemic myocardium. J Am Soc Echocardiogr. 2001 May;14(5):360-9. doi: 10.1067/mje.2001.110786.
citation: Chan J, Hanekom L, Wong C, Leano R, Cho GY, Marwick TH. Differentiation of subendocardial and transmural infarction using two-dimensional strain rate imaging to assess short-axis and long-axis myocardial function. J Am Coll Cardiol. 2006 Nov 21;48(10):2026-33. doi: 10.1016/j.jacc.2006.07.050. Epub 2006 Oct 31.