louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT03054246: Chewing Side Preference and Hemispheric Laterality in Healthy Adults
Official title: Chewing Side Preference is Associated With Hemispheric Laterality in Healthy Adults
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Mastication
Lead sponsor: Hacettepe University
Sponsor class: OTHER
First posted: 2017-02-15
Enrollment: 75
Sex: ALL
Minimum age (years): 18
Maximum age (years): 50
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: NA
Intervention model: SINGLE_GROUP
Intervention model description: Healthy volunteers
Primary purpose: OTHER

Brief summary: The study is aimed to investigate if chewing side preference (CSP) can be used as another indicator of hemispheric laterality in healthy adults. Healthy volunteers with no oral/dental problems with Angle I occlusion relationship and without any missing teeth will be included in the study. The CSP will be determined with the visual analog scale (VAS), which is the highly reliable method. Laterality test will be used to determine the preferred side for hands, feet, ears and eyes.

Detailed description: Lateral preference is important to determine hemispheric laterality, which is usually diagnosed by hand and other sidedness, including footedness, eyedness and earedness. study is aimed to investigate if chewing side preference (CSP) can be used as another indicator of hemispheric laterality in healthy adults. Healthy volunteers with no oral/dental problems with Angle I occlusion relationship and without any missing teeth will be included in the study. The CSP will be determined with the visual analog scale (VAS), which is the highly reliable method. Laterality test will be used to determine the preferred side for hands, feet, ears and eyes.

Eligibility criteria: Inclusion Criteria:

Healthy volunteers;

* Between the ages of 18-50 years
* Have no oral/dental problems with Angle I occlusion relationship and without any missing teeth
* Have no orofacial pain and/or no oral appliances will be included in the study.

Exclusion Criteria:

Participants;

* Under the age of 18 years and above the age of 50 years
* Have oral/dental problems with missing teeth
* Have orofacial pain
* Have oral appliances will be excluded from the study.

Primary outcomes:
measure: Chewing side
timeFrame: 1 month
Secondary outcomes:
measure: Laterality
timeFrame: 1 month
Other outcomes:
Locations:
city: Ankara
country: Turkey
facility: Hacetttepe University
Study officials:
affiliation: Hacettepe University
name: SELEN SEREL ARSLAN
role: PRINCIPAL_INVESTIGATOR
References:
citation: Serel Arslan S, Inal O, Demir N, Olmez MS, Karaduman AA. Chewing side preference is associated with hemispheric laterality in healthy adults. Somatosens Mot Res. 2017 Jun;34(2):92-95. doi: 10.1080/08990220.2017.1308923. Epub 2017 Apr 10.
Clinical trial NCT00411346: Patient Research In Self-Management of Asthma (PRISMA)
Official title: Nurse-Led Telemonitoring Programme in Asthmatic Outpatients: a Randomized Controlled Trial
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE4
Conditions: Asthma
Keywords: Asthma
Self-Monitoring
Cost-effectiveness
Lead sponsor: Maastricht University Medical Center
Sponsor class: OTHER
First posted: 2006-12-14
Enrollment: 112
Sex: ALL
Minimum age (years): 7
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: HEALTH_SERVICES_RESEARCH

Brief summary: The objective of this study was to investigate if a nurse-led telemonitoring programme is effective and cost-effective in asthmatic outpatients, aged seven years and older.

Detailed description: At the present day asthma is one of the most common chronic illnesses worldwide and the prevalence is still increasing. Asthma can be treated and controlled with guidance of health care professionals, and self-monitoring is an important aspect in this control.

Respiratory nurses have become common caregivers in the treatment and control of asthma. Advances in information and communication technology have created the potential to monitor the asthma status of patients at a distance, named telemonitoring. These two developments come together in nurse-led telemonitoring programmes. Lung function tests, from which the peak expiratory flow (PEF) is the most commonly used, are recorded into an electronic monitor. By transferring monitor data to a central database a nurse can continuously supervise the disease status of individual patients. The use of stepwise protocols can enable nurses to independently adjust the medication by one step.

Design: Randomized controlled trial comparing a nurse-led telemonitoring programme versus regular care in asthmatic outpatients aged 7 years and older.

Primary outcome parameter: asthma-specific quality of life. Secondary outcome parameters: symptoms, generic quality of life, direct and indirect costs, satisfaction.

Eligibility criteria: Inclusion Criteria:

* 7 years or older
* Asthma severity of stage I - III as described in the GINA guidelines
* Must be competent to use an asthma monitor
* Must possess a household phone connection

Exclusion Criteria:

* Respiratory co-morbidity

Primary outcomes:
measure: Asthma-specific quality of life at one year.
Secondary outcomes:
measure: Asthma symptoms at one year
measure: generic quality of life at one year
measure: direct and indirect costs during one year
measure: satisfaction with and feasibility of the intervention at one year.
Other outcomes:
Locations:
city: Maastricht
country: Netherlands
facility: University Hospital Maastricht
state: Limburg
Study officials:
affiliation: Department of Respiratory Medicine
name: Emiel FM Wouters, MD PhD
role: STUDY_CHAIR
References:
Clinical trial NCT00919646: Monitoring Arrhythmia Patients in in Hospital Monitoring
Official title: Arrhythmia Detection With Adherent Patient Monitoring Study
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Arrhythmias
Lead sponsor: Corventis, Inc.
Sponsor class: INDUSTRY
First posted: 2009-06-12
Enrollment: 30
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: CASE_ONLY
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Telemetry ward

Brief summary: This is a prospective, single center, non-randomized study to evaluate the arrhythmia monitoring performance of the AVIVO™ System in a hospital setting.

Detailed description: The AVIVO™ System will continuously monitor the patient's cardiac activity which will be compared to the performance of standard telemetry system.

Eligibility criteria: Inclusion Criteria:

* Is female or male, 18 years of age or older
* Undergoing in-hospital electrocardiographic monitoring for primarily cardiac reasons

Exclusion Criteria:

* Is participating in another clinical study that may confound the results of this study

Primary outcomes:
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
affiliation: Corventis, Inc.
name: Imad Libbus, PhD
role: STUDY_DIRECTOR
References:
Clinical trial NCT05112146: Effects of Whey Protein Pre-meals on Post-prandial Glucose
Official title: Effects of Whey Protein Pre-meals on Post-prandial Glucose
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Prediabetic State
Lead sponsor: Société des Produits Nestlé (SPN)
Sponsor class: INDUSTRY
First posted: 2021-11-08
Enrollment: 16
Sex: ALL
Minimum age (years): 40
Maximum age (years): 65
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: CROSSOVER
Primary purpose: TREATMENT

Brief summary: The aim of this project was to determine if an administration of either 10 g of whey protein isolate or 10 g of whey protein microgels 30 or 10 min before a standard meal could reduce postprandial glucose response in obese subjects.

Detailed description: Monocentric, controlled, randomized, open, complete cross-over study design where participants will take 2 test products or water (negative control) at 2 different time points.

The targeted population will be 16 completely healthy males and females at risk for pre-diabetes.

Primary objective: To quantify the effects of whey protein pre-meals administrated at 30 or 10 min before a meal on post-prandial glucose in the interstitial tissue, as compared to water as negative control.

Secondary objective: To compare glucose response of the different pre-meals (water, whey protein isolate, whey protein micelles).

Eligibility criteria: Inclusion Criteria:

* Male and female participant
* Age between 40 and 65 years
* BMI higher than 27.0 kg/m2
* Sedentarity (no more than 30 min of walk per day).
* Able to understand and sign an informed consent form

Exclusion Criteria:

* Any known metabolic disease including diabetes or chronic drug intake (aspirin, vitamin C and mineral supplements, steroids, protease inhibitors, antidepressants, anxiolytic, or antipsychotics...) possibly impacting (to the opinion of the medical doctor):
* The digestion or absorption of nutrients
* The postprandial glucose response
* Major medical/surgical event requiring hospitalization in the last 3 months, to the opinion of the medical doctor
* Known allergy and intolerance to products components
* Medically known cutaneous hypersensitivity to adhesives and plasters
* Alcohol intake higher than 2 servings per day. A serving is 0.4 dl of strong alcohols, 1 dl of red or white wine, or 3 dl of beer.
* Smokers
* Volunteer who cannot be expected to comply with the protocol
* Subject having a hierarchical link with the research team members

Primary outcomes:
measure: Post-prandial glucose
timeFrame: Hour 0 to hour 2 after standard meal consumption
Secondary outcomes:
measure: C max glucose
timeFrame: Hour 0 to hour 2 after standard meal consumption
measure: T max glucose
timeFrame: Hour 0 to hour 2 after standard meal consumption
Other outcomes:
Locations:
city: Lausanne
country: Switzerland
facility: Nestlé Clinical Research Unit
state: Vaud
Study officials:
affiliation: Nestlé Research
name: Christian Darimont
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT00179946: HLA Matching - Unrelated Umbilical Cord Blood Transplantation
Official title: Impact of HLA Matching on Outcome in Pediatric Patients Undergoing Unrelated Umbilical Cord Blood Transplantation.
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Hematologic Diseases
Lead sponsor: Ann & Robert H Lurie Children's Hospital of Chicago
Sponsor class: OTHER
First posted: 2005-09-16
Enrollment: 30
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Time perspective: PROSPECTIVE

Brief summary: The aim of this protocol is to clarify the role of HLA matching in unrelated umbilical cord blood (UCB) transplantation and to identify the level of HLA matching required assuring successful outcome of unrelated UCB transplantation.

Detailed description: The aim of this protocol is to clarify the role of HLA matching in unrelated umbilical cord blood (UCB) transplantation and to identify the level of HLA matching required assuring successful outcome of unrelated UCB transplantation.

The study will answer the following questions:

1. Is HLA matching beneficial to unrelated UCB transplantation?
2. Which HLA loci, HLA-A, B, C, DRB1, or BQB1 is/are important to math, or alternatively to mismatch, to improve graft survival?
3. Which HLA loci, HLA-A, B, C, DRB1, or BQB1 mismatches is/are "permissive mismatches" or well tolerated mismatches?
4. What level of typing resolution (low, intermediate, or hgh) is required to perform patient/donor H:A matching?

By studying the cells and blood of donors and recipients, we may learn more about improving the tissue matching between unrelated donors and their recipients. Also, we hope to learn if an additional level of matching testing improves the results of the transplant treatment. Increasing knowledge about tissue matching could result in the improved long-term survival of cord blood transplant recipients.

Eligibility criteria: Inclusion Criteria:

* Pediatric Patients undergoing an unrelated umbilical cord blood transplantation.

Exclusion Criteria:

* Refusal to participate in study.

Primary outcomes:
Secondary outcomes:
Other outcomes:
Locations:
city: Chicago
country: United States
facility: Ann & Robert H Lurie Children's Hospital of Chicago
state: Illinois
Study officials:
affiliation: Ann & Robert H Lurie Children's Hospital of Chicago
name: Sonali Chadhury, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT05840146: Kineesiotaping for Patients With LCPD
Official title: Effects of Kinesiotaping in Patients With Legg-Calvé-Perthes Disease: A Randomized, Double-blind, Placebo-controlled Trial
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Legg-Calve-Perthes Disease
Keywords: Kinesiotape
Taping
Pediatric pain
Hip joint
Physiotherapy
Lead sponsor: Istanbul University - Cerrahpasa
Sponsor class: OTHER
First posted: 2023-05-03
Enrollment: 30
Sex: ALL
Minimum age (years): 5
Maximum age (years): 18
Standard ages: CHILD
ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: Kinesiotaping is increasingly being used as a complement to musculoskeletal pain management. This study aimed to evaluate the immediate clinical efficacy of kinesiotaping on pain and pain-related symptoms of Legg-Calvé-Perthes Disease (LCPD).

Detailed description: Kinesio taping is increasingly being used as a complement to musculoskeletal pain management. A randomized, double-blind, placebo-controlled clinical trial was conducted. Activity-related hip pain, passive and pain limited hip range of motion, gluteus medius muscle strength, function and balance were assessed.

Eligibility criteria: Inclusion Criteria:

* Having received unilateral LCPD diagnosis,
* Anterior hip pain minimum three points on 10-cm Visual Analog Scale (VAS) over the previous week,
* Having the following symptoms; weakness of gluteus medius muscle and patient-reported complaints on function or balance

Exclusion Criteria:

* Having a history of any other hip pathologies,
* Having allergy to polyacrylate adhesive,
* Having used analgesic medication within the previous three days.

Primary outcomes:
measure: Immediate Clinical Efficacy on Activity Related Hip
timeFrame: The change between T1 (baseline) to T2 (thirty minutes later from the application)
Secondary outcomes:
measure: Immediate Clinical Efficacy on Hip Abduction ROM
timeFrame: The change between T1 (baseline) to T2 (thirty minutes later from the application)
measure: Immediate Clinical Efficacy on Functional Task Durations
timeFrame: The change between T1 (baseline) to T2 (thirty minutes later from the application)
measure: Immediate Clinical Efficacy on Balance test durations
timeFrame: The change between T1 (baseline) to T2 (thirty minutes later from the application)
measure: Immediate Clinical Efficacy on Gluteus medius muscle strength
timeFrame: The change between T1 (baseline) to T2 (thirty minutes later from the application)
Other outcomes:
Locations:
city: Istanbul
country: Turkey
facility: Istanbul University-Cerrahpasa
Study officials:
References:
Clinical trial NCT02408146: The Effect of Parecoxib Sodium Intravenous Patient-controlled Analgesia in Laparotomic Liver Resection
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Pain, Postoperative
Lead sponsor: First Affiliated Hospital of Harbin Medical University
Sponsor class: OTHER
First posted: 2015-04-03
Enrollment: 80
Sex: ALL
Minimum age (years): 18
Maximum age (years): 70
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The investigators hypothesized that using new intravenous infusion pump of patient-controlled analgesia (parecoxib sodium 1 mg/mL + normal saline) would significantly improve postoperative pain control compare to conventional intravenous infusion pump of patient-controlled analgesia (fentanyl citrate 20 mg/mL/kg + ondansetron hydrochloride 16 mg/8 mL + normal saline). This prospective randomized controlled trial was designed to evaluate the benefit of new intravenous infusion pump of patient-controlled analgesia (parecoxib sodium 1 mg/mL + normal saline) for postoperative analgesia after laparotomic liver resection.


Eligibility criteria: Inclusion Criteria:

Patients need laparotomic liver resection.

Exclusion Criteria:

Patients with contraindications to spinal anesthesia or intrathecal morphine, difficulty understanding passive cutaneous anaphylaxis, a history of drug dependence or chronic pain, body mass index greater than 35 kg/m2, or history of sleep apnea were excluded from this study.

Primary outcomes:
measure: The measure is a composite outcome measure consisting of multiple measures,pain scores, sedation, nausea, pruritus, and respiratory rate.
timeFrame: With or without changes in the three days after surgery
Secondary outcomes:
Other outcomes:
Locations:
city: Harbin
country: China
facility: harbin Medical University
state: Heilongjiang
Study officials:
References:
Clinical trial NCT01435746: Transfusion Requirements After Orthotopic Liver Transplantation
Official title: A Randomized, Controlled Pilot Trial of Transfusion Requirements After Orthotopic Liver
Study type: INTERVENTIONAL
Overall status: WITHDRAWN
Phase: NA
Conditions: Anemia
Keywords: liver transplantation
intensive care
red blood cell transfusion
Lead sponsor: University Medical Center Goettingen
Sponsor class: OTHER
First posted: 2011-09-19
Enrollment: 0
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The objective of this trial is to evaluate different transfusion strategies in patients after liver transplantation. Patients in the experimental arm will be given red blood cell (RBC) transfusion according to a liberal strategy, i. e., transfusions should be given, when hemoglobin concentration falls below 10 g/dl, and hemoglobin concentration should be maintained between 10 and 12 g/dl. Patients in the control arm will be given red blood cell (RBC) transfusion according to a restrictive strategy, i. e., transfusions should be given, when hemoglobin concentration falls below 8 g/dl, and hemoglobin concentration should be maintained between 8 and 10 g/dl.


Eligibility criteria: Inclusion Criteria:

* Patients undergoing liver transplantation
* Patients considered to have euvolemia after initial treatment by attending physicians

Exclusion Criteria:

* Patients age 18 or less
* Patients undergoing combined liver-kidney transplantation
* Patients requiring renal replacement therapy before liver transplantation for longer than two weeks
* Inability to receive blood products
* Patient with active blood loss at the time of enrollment
* Pregnancy
* Imminent death

Primary outcomes:
measure: Composite of death, graft loss and renal failure
timeFrame: 30 days after randomization
Secondary outcomes:
measure: Renal function
timeFrame: 30 days after randomization
Other outcomes:
Locations:
city: Göttingen
country: Germany
facility: University Medical Center Göttingen
state: Niedersachsen
Study officials:
References:
Clinical trial NCT06404346: Comparative Effectiveness of HVT and Bowen Technique in Patients of SI Joint Dysfunction With Upslipped Innominates
Official title: Comparative Effectiveness of High Velocity Thrust and Bowen Technique in Patients of SI Joint Dysfunction With Upslipped Innominates. A Randomized Controlled Trial
Study type: INTERVENTIONAL
Overall status: ACTIVE_NOT_RECRUITING
Phase: NA
Conditions: Joint Diseases
Lead sponsor: Superior University
Sponsor class: OTHER
First posted: 2024-05-08
Enrollment: 26
Sex: ALL
Minimum age (years): 18
Maximum age (years): 35
Standard ages: ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: DIAGNOSTIC

Brief summary: Sacroiliac joint dysfunction (SIJD) is a common musculoskeletal condition characterized by pain and impaired function in the lower back and pelvis region.

Detailed description: The reported prevalence of sacroiliac joint pain in cases of chronic low back and lower extremity pain is estimated to be between 10 - 27%. Manual therapy techniques, such as High-Velocity Thrust (HVT) and the Bowen Technique, have emerged as potential treatment options for SIJD. HVT involves quick, controlled movements applied to specific joints to restore normal range of motion and alleviate pain. Conversely, the Bowen Technique is a gentle, non-invasive form of bodywork that utilizes subtle rolling movements over muscles and connective tissues to promote relaxation and restore balance within the body.

Eligibility criteria: Inclusion Criteria:

* Diagnosis of sacroiliac joint dysfunction confirmed by clinical assessment and imaging findings.
* The presence of an upslipped innominate observed on imaging studies.

Exclusion Criteria:

* History of significant trauma or surgery involving the sacroiliac joint region.
* The presence of inflammatory or infectious conditions affecting the sacroiliac joint.
* Contraindications to manual therapy interventions such as HVT or the Bowen Technique.
* Inability to comprehend study procedures or provide informed consent

Primary outcomes:
measure: Oswestry Disability Index (ODI)
timeFrame: 12 Months
measure: Visual Analog Scale(VAS)
timeFrame: 12 months
Secondary outcomes:
Other outcomes:
Locations:
city: Lahore
country: Pakistan
facility: Govt. Hospital Kot Kahwaja Saeed
state: Punjab
Study officials:
References: