Clinical trial NCT05795556: Biomarkers of Sarcopenia and Frailty in Geriatric Patients
Official title: Biomarkers of Sarcopenia and Frailty in Geriatric Patients
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Sarcopenia
Muscle Loss
Fall Patients
Lead sponsor: Herlev and Gentofte Hospital
Sponsor class: OTHER
Collaborators: name: Bispebjerg Hospital
First posted: 2023-04-03
Enrollment: 508
Sex: ALL
Minimum age (years): 65
Standard ages: OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: CROSS_SECTIONAL
Sampling method: NON_PROBABILITY_SAMPLE
Study population: The study population will consist of participants referred to the fall clinic at Gentofte Hospital

Brief summary: During the last decades there has been an increase in the relative proportion and life expectancy of elderly people. Hence, the number of elderly with diseases and disabilities related to aging will increase and consequently, age-related losses in skeletal muscle mass and physical function represents an important current and future public health issue. Sarcopenia is a progressive and generalized skeletal muscle disorder that is considered central to the development of physical deconditioning and untreated sarcopenia is linked to falls, morbidity, and mortality.

The underlying mechanisms behind the progressive loss of muscle mass and function associated with aging are yet unknown but seems to be multifactorial. A decrease in physical activity level and an altered central and peripheral nervous system innervation have been identified as some of the contributing factors. Furthermore, chronic low-grade inflammation has been proposed as a central contributor to sarcopenia and thus physical frailty.

However, it is not yet clear whether the elevated markers of inflammation seen in the elderly are due to aging, chronic illness, or inactivity. But overall, it seems that inflammation plays an important role in the development of muscle loss, and is related to increased risk of falls, fragility, and early death.


Eligibility criteria: Inclusion Criteria:

* Geriatric patients referred to out-patient clinic for fall assessments
* equal to or over the age of 65

Exclusion Criteria:

* age under 65 years
* participants who do not understand Danish
* severe communicative problems
* moderate to severe dementia or cognitive deficits
* no independent walking

Primary outcomes:
measure: Skeletal muscle mass
timeFrame: Baseline
measure: Appendicular lean muscle mass
timeFrame: Baseline
measure: Skeletal muscle mass index (SMI)
timeFrame: Baseline
Secondary outcomes:
measure: Muscle Thickness
timeFrame: Baseline
measure: Muscle strength (upper body)
timeFrame: Baseline
measure: Muscle strength (lower body)
timeFrame: Baseline
measure: Physical Activity (Chair rise)
timeFrame: Baseline
measure: Physical Activity (Gait speed)
timeFrame: Baseline
measure: Postural sway
timeFrame: Baseline
measure: SARC-F (sarcopenia screening)
timeFrame: Baseline
measure: Geriatric Depression Scale (GDS-15)
timeFrame: Baseline
measure: SNAQ (malnutrition)
timeFrame: Baseline
Other outcomes:
Locations:
city: Copenhagen
country: Denmark
facility: Pernille Hansen
state: Hellerup
Study officials:
affiliation: Charlotte Suetta
name: Charlotte Suetta, Professor
role: PRINCIPAL_INVESTIGATOR
References: