Clinical trial NCT03861585: Emotional Information Processing in Attention Deficit Disorder With or Without Hyperactivity
Official title: Attentional and Emotional Processing of Complex Visual Scenes in Children With Attention Deficit Disorder With or Without Hyperactivity
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Attention Deficit Disorder With Hyperactivity
Attention Deficit Disorder Without Hyperactivity
Lead sponsor: Fondation Lenval
Sponsor class: OTHER
First posted: 2019-03-04
Enrollment: 54
Sex: ALL
Minimum age (years): 7
Maximum age (years): 12
Standard ages: CHILD
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: BASIC_SCIENCE

Brief summary: The aim of this study is to analyse explicit and implicit emotional information processing abilities in children with attention deficit disorder with or without hyperactivity

Detailed description: The main symptoms of Attentional Deficit Hyperactivity Disorder (ADHD) are inattention, motor agitation and impulsivity. However, other dysfunctions affecting the quality of life remain poorly studied: lack of understanding and management of emotions, focus on the local aspects of a visual scene limiting the ability to assign a general meaning to the scene and alteration of long-term memory encoding. This study aims to analyse these difficulties using different tasks requiring processing of rich and varied everyday images, having high ecological validity. It involves the participation of 56 boys and girls with ADHD, aged 7 to 12 years. A first phase examines the immediate understanding of images using two tasks: semantic categorization (Experiment 1) and emotional evaluation (Experiment 2) of images with positive, negative or neutral emotional valence, and depicting real environments (natural vs. manufactured contexts) or foreground objects pasted into a noise background (inanimate objects vs. animals vs. people. In each trial, one context image and one object image are presented briefly and simultaneously, one in each visual field. In order to be appropriately understood in both their semantic and emotional contents, context images will require more global processing, while object images will require more local, detailed processing. Their semantic (Exp. 1) and emotional (Exp. 2) consistency is manipulated. A week later, the participants have to perform a memory task requiring old/new recognition in a two-alternative forced choice (2AFC) paradigm that presents in each trial a pair of images (one old, one new) having the same emotional valence (Exp. 3). The study will characterize the specificities of processing and representing visual emotional information in ADHD children. The results will be compared with those from a previous study we conducted with the same methodology on neuro-typical children (controls).

Eligibility criteria: Inclusion Criteria:

* Children between 7 and 12 years old..................................
* Normal or corrected visual acuity .....................................
* ADHD diagnostic given by a doctor according to DSM 5 criteria (Diagnostic and Statistical Manual of Mental Disorders)
* Free from drug treatment until 24 hours before the experiment session............................
* Affiliation to a social security system.........................
* Signature of the authorization documents from one parent or the holder of parental authority

Exclusion Criteria:

-History of neurological troubles, dysphasia, autistic spectrum disorder, intellectual disabilities

Primary outcomes:
measure: 1. Accuracy and response time at an explicit emotional evaluation task of visual scenes, by children with Attentional Deficit Hyperactivity Disorder (ADHD)
timeFrame: at baseline Day 0
measure: 2. Accuracy and response time at a semantic categorization task of visual scenes, by children with Attentional Deficit Hyperactivity Disorder (ADHD)
timeFrame: at baseline Day 0
Secondary outcomes:
measure: Proportion and response time of correct response for the contextual images compared to the local images at the semantic categorization task for ADHD's participants
timeFrame: at baseline Day 0
measure: Proportion and response time of correct response for the contextual images compared to the local images at the emotional evaluation task for ADHD's participants
timeFrame: at baseline Day 0
measure: Influence of the image's emotional content (i.e. neutral, positive or negative) on long term memory in ADHD participants
timeFrame: at 1 week from the first evaluation
measure: Performance on long term memory in ADHD participants
timeFrame: at 1 week from the first evaluation
Other outcomes:
Locations:
city: Nice
country: France
facility: Hôpitaux Pédiatriques de Nice CHU-Lenval
Study officials:
affiliation: Fondation Lenval - Nice Children Hôpitaux Pédiatriques de Nice
name: FOSSOUD Catherine, MD
role: PRINCIPAL_INVESTIGATOR
References: