Clinical trial NCT03211507: Idiopathic Pulmonary Fibrosis Job Exposures Study
Official title: Idiopathic Pulmonary Fibrosis Job Exposures Study
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: IPF
Idiopathic Pulmonary Fibrosis
Keywords: Idiopathic Pulmonary Fibrosis
Lead sponsor: Imperial College London
Sponsor class: OTHER
Collaborators: name: Wellcome Trust
name: University Hospital Southampton NHS Foundation Trust
name: Imperial College Healthcare NHS Trust
name: Heart of England NHS Foundation Trust
name: Liverpool University Hospitals NHS Foundation Trust
name: Papworth Hospital NHS Foundation Trust
name: Nottingham University Hospitals NHS Trust
name: University Hospital of South Manchester
name: Guy's and St Thomas' NHS Foundation Trust
name: North Bristol NHS Trust
name: The Leeds Teaching Hospitals NHS Trust
name: Newcastle-upon-Tyne Hospitals NHS Trust
name: Royal Devon and Exeter NHS Foundation Trust
name: Somerset NHS Foundation Trust
name: Royal Infirmary of Edinburgh
name: Morriston Hospital
name: Aberdeen Royal Infirmary
name: Worcestershire Acute Hospitals NHS Trust
name: University Hospital Birmingham NHS Foundation Trust
name: Portsmouth Hospitals NHS Trust
name: Norfolk and Norwich University Hospitals NHS Foundation Trust
name: Glasgow Royal Infirmary
First posted: 2017-07-07
Enrollment: 960
Sex: MALE
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: CASE_CONTROL
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: Hospital based

Brief summary: A case-control study to investigate whether job exposures are an under-recognized cause of idiopathic pulmonary fibrosis (IPF) using an interview to collect information about previous jobs and a blood test to investigate genetic susceptibility.

Detailed description: Idiopathic pulmonary fibrosis (IPF) is a scarring lung disease. It damages the air sacs that allow oxygen to be transferred into the blood and transported to vital organs. These changes make people with IPF cough and feel short of breath. It not known what causes the damage. People who get IPF are usually older than 40; it's a very serious illness that cannot be cured and gets worse over time. Statistics show that IPF is becoming more common in the UK but it's not known why. It can be difficult for doctors to tell if someone has IPF or another disease called asbestosis.

Eligibility criteria: For cases

Inclusion Criteria:

* New diagnosis of IPF between February 2017 and October 2019

Exclusion Criteria:

* Unable to give informed consent
* Ever worked outside of the UK

For controls

Inclusion Criteria:

* New outpatient department attendee between February 2017 and October 2019

Exclusion Criteria:

* Unable to give informed consent
* Ever worked outside of the UK (does not include work outside the UK by members of the armed forces or merchant navy)
* Diagnosis of IPF

Primary outcomes:
measure: Association between asbestos exposure and IPF
timeFrame: 2 years
Secondary outcomes:
measure: Dose-response relationship between asbestos exposure and IPF
timeFrame: 2 years
measure: Gene-environment interaction (for MUC5B rs35705950 and asbestos exposure) odds ratio.
timeFrame: 2 years
Other outcomes:
Locations:
city: London
country: United Kingdom
facility: Imperial Healthcare NHS Trust
Study officials:
affiliation: Imperial College London
name: Carl Reynolds
role: STUDY_DIRECTOR
References: