Clinical trial NCT05930717: Zhejiang Nutrition and Health Study
Official title: Zhejiang Nutrition and Health Study: Nutrition and Lifespan Study (NuLife Study)
Study type: OBSERVATIONAL
Overall status: WITHDRAWN
Conditions: Metabolic Disease
Cardiovascular Diseases
Healthy Aging
Keywords: Nutrition
Health
Healthy lifespan
Lead sponsor: Westlake University
Sponsor class: OTHER
Collaborators: name: Zhejiang Provincial Center for Disease Control and Prevention
First posted: 2023-07-05
Enrollment: 0
Sex: ALL
Minimum age (years): 6
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: Permanent residents in Zhejiang Province

Brief summary: This project aims to explore the relationship between healthy lifespan and nutrition through a 10-year longitudinal study in Zhejiang Province. The cohort will include individuals in a wide range of age groups. The demographic, diet, lifestyle information, health status, and corresponding bio-samples will be collected carefully. It will give a deeper insight to the relation between nutrition and healthy aging and longevity. Ultimately, this research will contribute to evidence-based nutrition interventions to improve health outcomes and enhance quality of life.

Detailed description: This project aims to elucidate the relationship between healthy lifespan and nutrition through the establishment of a large-scale cohort of participants and longitudinal follow-ups spanning around 10 years in Zhejiang Province. The cohort will comprise individuals in a wide range of age groups starting at 6 years old. The participants will provide demographic information, anthropometry measurements, detailed diet, lifestyle data and health status, including 3-day dietary records and long-term food intake frequency recalls. Integrated with previous information, diverse bio-samples will also be collected to establish a multi-dimensional biobank. It will give a deeper insight to the relation between nutrition and healthy aging and longevity. Ultimately, this research will contribute to the development of evidence-based nutrition designed to improve health outcomes and enhance the quality of life for individuals of all ages.

Eligibility criteria: Inclusion Criteria:

* Chinese citizens who have resided in the surveyed area for at least 6 months before the survey within the last 12 months.
* Aged 6 years or older.
* They are included as resident households, which are comprised of people living together in one place based on family relationships, and at least one resident with permanent household registration.

Exclusion Criteria:

* Residents living in functional zones such as construction worker dormitories, military barracks, schools, nursing homes, etc.

Primary outcomes:
measure: Occurrence of cardio-metabolic diseases
timeFrame: up to 10 years
Secondary outcomes:
measure: Changes in fasting blood glucose
timeFrame: Every other year， up to 10 years
measure: Changes in fasting blood HbA1c
timeFrame: Every other year， up to 10 years
measure: Changes in fasting lipid metabolism
timeFrame: Every other year， up to 10 years
measure: Changes in fasting blood highly sensitive C-reactive protein (CRP)
timeFrame: Every other year， up to 10 years
measure: Changes in body mass index
timeFrame: Every other year， up to 10 years
measure: Changes in blood pressure
timeFrame: Every other year， up to 10 years
measure: Changes in gut microbiome profiling
timeFrame: Every other year， up to 10 years
Other outcomes:
Locations:
city: Hangzhou
country: China
facility: Zhejiang Provincial Center for Disease Control and Prevention
state: Zhejiang
city: Hangzhou
country: China
facility: Westlake University
state: Zhejiang
Study officials:
affiliation: Westlake University
name: Ju-Sheng Zheng, PhD
role: PRINCIPAL_INVESTIGATOR
References: