Clinical trial NCT04986215: Research on the Value of Genomics Research Based on Ultrasound Endoscopic Biopsy in the Differential Diagnosis and Prognostic Evaluation of Pancreatic Occupancy
Official title: Research on the Value of Genomics Research Based on Ultrasound Endoscopic Biopsy in the Differential Diagnosis and Prognostic Evaluation of Pancreatic Occupancy
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Pancreatic Space Occupying
Lead sponsor: Changhai Hospital
Sponsor class: OTHER
First posted: 2021-08-02
Enrollment: 300
Sex: ALL
Minimum age (years): 18
Maximum age (years): 85
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: CASE_CONTROL
Time perspective: OTHER
Sampling method: PROBABILITY_SAMPLE
Study population: Occupying lesions of the pancreas, specifically including benign diseases and malignant diseases, mainly pancreatic cancer has a very high incidence. Elderly patients, especially those who drink alcohol all year round, have a lot of occurrences, and many patients are already in the middle or advanced stage when they are diagnosed.

Brief summary: To clarify the value of genomic testing in the clinical diagnosis or prognosis of pancreatic space occupation, provide a basis for the selection of clinical diagnosis methods for pancreatic space occupation, optimize clinical management strategies, and improve the prognosis of patients.


Eligibility criteria: Inclusion Criteria:

1. Age 18-85, no gender limit
2. Imaging examinations suggest that the clear pancreas has clear space-occupying lesions
3. Admitted to our department, ready to undergo endoscopic ultrasound biopsy to confirm the diagnosis

Exclusion Criteria:

1. There are contraindications for endoscopic ultrasound biopsy
2. Failed to join the group or refused follow-up due to various reasons

Primary outcomes:
measure: Differential microRNA detected by sequencing
timeFrame: June 2023
measure: Differential mRNA detected by sequencing
timeFrame: June 2023
measure: Differential lncRNA detected by sequencing
timeFrame: June 2023
Secondary outcomes:
Other outcomes:
Locations:
city: Shanghai
country: China
facility: Shanghai Changhai Hospital
state: Shanghai
Study officials:
References:
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