Clinical trial NCT06949995: Effects of Blood Flow Restriction on Post-Exercise Recovery in Amateur Runners
Official title: Effects of Blood Flow Restriction on Post-Exercise Recovery in Amateur Runners: A Stratified Randomized Controlled Trial
Study type: INTERVENTIONAL
Overall status: ENROLLING_BY_INVITATION
Phase: NA
Conditions: Recovery Methods
Recovery Time
Keywords: Running
physiological stress
functional physical performance
post-exercise recovery techniques
blood flow restriction therapy
Lead sponsor: Paulista University
Sponsor class: OTHER
First posted: 2025-04-29
Enrollment: 34
Sex: MALE
Minimum age (years): 18
Maximum age (years): 40
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: OTHER

Brief summary: Street running has become an increasingly popular sport. As a result, effective recovery strategies after exercise are essential. In this context, two techniques stand out: one already validated, active recovery (AR), and another with potential, blood flow restriction (BFR). This study aims to investigate whether using both techniques simultaneously can benefit practitioners and improve outcomes compared to complete rest.

Detailed description: This randomized clinical trial aims to evaluate the effects of combining active recovery (AR) and blood flow restriction (BFR) on post-exercise recovery in amateur runners. Thirty-four healthy male participants aged 18-40 years, who run at a pace faster than 5:30 min/km, will be stratified based on their performance in the 3-minute all-out running test and randomly assigned to one of three groups: AR with BFR, AR alone, or passive rest (control). All participants will undergo baseline assessments, followed by a muscle stress protocol, the assigned recovery strategy, and follow-up evaluations immediately, and at 24, 48, 72, and 96 hours post-exercise.

Outcomes include heart rate variability (via RR intervals), muscle soreness (Numeric Rating Scale), recovery perception and discomfort (Likert scale), effort (Borg CR-10), cellular integrity (bioelectrical impedance), pain threshold (pressure algometer), muscle tone, stiffness, and elasticity (myotonometry), muscle power (Squat Jump test), plantar flexor strength (digital dynamometer), and maximal aerobic capacity (3-minute test). Data will be analyzed using descriptive statistics and repeated measures ANOVA, with significance set at p\<0.05.

Participants will be duly informed about the procedures and objectives of this study, and after agreeing, they will sign an informed consent form, effectively becoming part of it. In the consent form, participants will be asked if they agree to the use of their data if they choose to withdraw from the study. Participants will also be asked for permission for the research team to share relevant data with people at universities participating in the research or regulatory authorities, where relevant. The study will be sent for consideration and approval to the Research Ethics Committee of FCT/UNESP, Presidente Prudente, SP, Brazil.

Eligibility criteria: Inclusion Criteria:

* Individuals who present one or more of the following characteristics will not be included:
* 1 presence of any health condition that contraindicates or prevents exercise;
* 2 diabetes and diagnosed high blood pressure;
* 3 inflammatory, psychiatric, cardiovascular and/or respiratory rheumatological disease; - -4 being dependent on alcohol, consuming drugs and/or being a smoker;
* 5 history of knee surgery (e.g., meniscal repair and ligament reconstruction) or recent lower limb musculoskeletal injury that may impair performance during tests or interventions (e.g., muscle injury, tendinopathy, patellofemoral pain and/or back pain column in the last six months);
* 6 use of ergogenic supplements to improve physical performance and/or muscle mass and/or vasoactive medications;
* 7 having one or more risk factors predisposing to thromboembolism

Exclusion Criteria:

* Participants will be excluded from the study if they:
* 1 have a health problem that does not allow them to continue;
* 2 wish to leave the study;
* 3 not sign the consent form

Primary outcomes:
measure: Isometric strength of the triceps surae
timeFrame: Change from baseline at 96 hours after exercise
measure: Aerobic capacity
timeFrame: Change from baseline at 96 hours after exercise
measure: Lower limb muscle power
timeFrame: Change from baseline at 96 hours after exercise
measure: Muscle soreness and pain threshold
timeFrame: Change from baseline at 96 hours after exercise
measure: Perceived exertion, recovery, and discomfort
timeFrame: Change from baseline at 96 hours after exercise
measure: Myotonometry
timeFrame: Change from baseline at 96 hours after exercise
measure: Bioelectrical impedance analysis
timeFrame: Change from baseline at 96 hours after exercise
measure: Heart rate variability (HRV)
timeFrame: Change from baseline at 96 hours after exercise
Secondary outcomes:
Other outcomes:
measure: Occlusion pressures (AOP)
timeFrame: Baseline
Locations:
city: Presidente Prudente
country: Brazil
facility: Franciele Marques Vanderlei
state: SP
Study officials:
References: