Clinical trial NCT00572871: Hormonal and Bone Turnover Marker Response to an Acute Bout of Resistance or Plyometric Exercise
Official title: Hormonal and Bone Turnover Marker Response to an Acute Bout of Resistance or Plyometric Exercise
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Osteoporosis
Osteopenia
Lead sponsor: University of Missouri-Columbia
Sponsor class: OTHER
First posted: 2007-12-13
Enrollment: 12
Sex: MALE
Minimum age (years): 25
Maximum age (years): 65
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: CASE_ONLY
Time perspective: CROSS_SECTIONAL
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Male participants apparently healthy and non-sedentary free of disease that affects bone and not have used or currently use any medication that affects bone.

Brief summary: We are interested in determining if there exist a short-term response in the serum markers and hormones that participate in the regulation of bone tissue formation and breakdown to a single, high-intensity exercise session of weight lifting (resistance exercise) or jumping (plyometrics). We are also interested in determining if the bone marker response to exercise is altered by changing the negative energy state caused by the exercise treatment, when subjects are given a moderate calorie meal.

Detailed description: Bone tissue responds to impact and strain forces, like high-intensity exercise, by upregulating the bone remolding process, resulting in the deposition of calcium phosphate minerals into the collagen matrix of bone. Bone remodeling is a continually active process that involves both activation cells regulating bone formation (osteoblasts) and resorption (osteoclasts). Alterations in the balance between formation and resorption are critical for changes in bone density and mineral content to occur, which is regulated by several hormones including vitamin D and growth hormone, the sex hormones estrogen and testosterone, and parathyroid hormone. Importantly, it remains unclear how single bouts of physical activity contribute to the overall changes in remodeling and whether those acute alterations can be detected in the hours after exercise. Additionally, research studies examining the effects of exercise on bone remodeling often draw blood samples after 24 hours of physical inactivity, potentially diminishing the magnitude of the exercise response. Therefore, we plan to evaluate the acute effects of plyometrics and resistance exercise on changes in serum hormones and markers of bone turnover in non-sedentary, healthy males, with or without a moderate calorie supplement.

Eligibility criteria: Inclusion Criteria:

* Male
* No symptoms of disease
* Non-sedentary
* Age 25-65

Exclusion Criteria:

* Medications or supplements that affect bone metabolism or prevent exercise
* Previous or current medical condition affecting bone health, including osteoporosis.
* Cardiovascular disease
* Metallic implants affecting accuracy of bone density scan
* Current smoker
* Current participation in high-intensity jumping or resistance exercise in the last 3 months.

Primary outcomes:
measure: serum bone turnover markers
timeFrame: 24 hours
Secondary outcomes:
measure: serum hormones regulating bone turnover
timeFrame: 24 hours
Other outcomes:
Locations:
Study officials:
affiliation: University of Missouri-Columbia
name: Pamela S Hinton, Ph.D.
role: PRINCIPAL_INVESTIGATOR
References: