Clinical trial NCT05067881: Post-COVID-19 Pneumo-hematocele
Official title: Post COVID-19 Pneumo-hematocele: Clinical Presentation and Treatment Pathway
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: COVID-19 Respiratory Infection
Keywords: COVID-19
Pneumohematocele
Giant bullae
Pneumatocele
Lead sponsor: Hospital General Ajusco Medio
Sponsor class: OTHER
Collaborators: name: Instituto Nacional de Enfermedades Respiratorias
First posted: 2021-10-05
Enrollment: 37
Sex: ALL
Minimum age (years): 18
Maximum age (years): 80
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: CASE_ONLY
Time perspective: RETROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Patients with a positive chain reaction for SARS CoV-2 who had PHC on imaging studies in two hospitals of Mexico City

Brief summary: Introduction. As the COVID-19 pandemic has continued, an increasing number of long-term complications are emerging. Recently, the appearance of characteristic pulmonary lesions has been noted, being described as post COVID-19 pneumatocele. The aim of this study is to describe the clinical, histopathologic and imaging features of post COVID-19 pneumo-hematoceles (PHC) and secondarily to suggest a treatment algorithm in these patients.

Methods. A retrospective study was performed in patients admitted with diagnosis of SARS-CoV2 infection from March 2020 to September 2021 who presented PHC on imaging studies. Clinical and demographic variables were recorded and CT scans were analyzed. A logistic regression analysis was performed to determine the risk for rupture according to PHC characteristics.

It appears that PHC occurs secondary to encapsulation of blood accumulation, the result of micro capillary bleeding, with partial reabsorption of blood and subsequent air filling. The recommendation is to operate on patients with PHC of 5cm and those with persistent lesions of 3cm.


Eligibility criteria: Inclusion Criteria:

* Adults with a positive protein chain reaction for SARS-CoV2,
* PHC on imaging studies.

Exclusion Criteria:

* loss of follow up
* age out of range.

Primary outcomes:
measure: PHC diagnosis
timeFrame: From date of diagnosis until 4 weeks after diagnosis
Secondary outcomes:
Other outcomes:
Locations:
city: Mexico City
country: Mexico
facility: Karla Verónica Chávez Tostado
Study officials:
affiliation: Head of surgery department
name: Karla V Chavez Tostado, MD
role: PRINCIPAL_INVESTIGATOR
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