louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT00618085: Motor Imagery Practice in Neurological Rehabilitation
Official title: An Integrated Motor Imagery Program in Rehabilitation - a RCT
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE2
Conditions: Stroke
Brain Injury
Multiple Sclerosis
Lead sponsor: Nuffield Orthopaedic Centre NHS Trust
Sponsor class: OTHER
Collaborators: name: Oxford Brookes University
First posted: 2008-02-18
Enrollment: 50
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: Motor imagery is a technique widely used in learning skills. Its effectiveness has been proven in various sports and in musicians. A recent review (Braun et al. 2006) suggested that this technique may also be effective in rehabilitation of patients with neurological disease or damage, but that further research was needed.

The main purpose of this research is to discover whether motor imagery practice is beneficial in the rehabilitation of skills in patients who have some disability due to neurological disease or damage. The principal research question is: are physiotherapy and occupational therapy given incorporating motor imagery more effective than standard care (i.e., the same therapies but without integrated motor imagery) in re-training task specific performance for patients with neurological disease or damage?


Eligibility criteria: Inclusion Criteria:

* Participating in a rehabilitation program for problems arising secondary to disease or damage affecting the central nervous system (usually stroke, brain injury, multiple sclerosis)
* Over 18 years of age
* Have sufficient language and memory skills to undertake the intervention (i.e. score positive on the first three items of the Sheffield screening test)

Exclusion Criteria:

* Any co-morbidity that would interfere with the ability to perform imagery as judged by the clinician or from the medical notes (e.g., schizophrenia)

Primary outcomes:
measure: Goal Attainment Scaling
timeFrame: After 6 and 12 weeks
Secondary outcomes:
measure: Motor imagery questionnaire
timeFrame: Baseline, 6 weeks, 12 weeks
measure: Timed up and go
timeFrame: Baseline, 6 weeks, 12 weeks
measure: Action research arm test
timeFrame: Baseline, 6 weeks, 12 weeks
Other outcomes:
Locations:
city: Oxford
country: United Kingdom
facility: Oxford Centre for Enablement
Study officials:
affiliation: Oxford Centre for Enablement
name: Thamar J Bovend'Eerdt, MSc
role: PRINCIPAL_INVESTIGATOR
affiliation: Oxford Centre for Enablement
name: Derick T Wade, MD
role: STUDY_DIRECTOR
References:
citation: Braun SM, Beurskens AJ, Borm PJ, Schack T, Wade DT. The effects of mental practice in stroke rehabilitation: a systematic review. Arch Phys Med Rehabil. 2006 Jun;87(6):842-52. doi: 10.1016/j.apmr.2006.02.034.
Clinical trial NCT05738785: Risk of Osteoporotic Fracture in Home Care Patients in Turkey
Official title: Risk of Osteoporotic Fracture in Home Care Patients in Turkey: A Call for Action
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Osteoporosis
Osteoporosis Risk
Osteoporotic Fractures
Lead sponsor: Uskudar State Hospital
Sponsor class: OTHER_GOV
First posted: 2023-02-22
Enrollment: 370
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Observational model: ECOLOGIC_OR_COMMUNITY
Time perspective: RETROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Home care patients who have called home health services in the last 6 months.

Brief summary: This study will assess the incidence of osteoporosis and osteoporotic fracture risk of registered home health patients in the Anatolian side of Istanbul.

Detailed description: After selecting the patients who have been visited by the team in the last 6 months from the patients registered in the home health system, the number of patients required to reflect the population will be determined, and patient files will be selected by randomization. Demographic information, comorbidities, medications, and blood tests will be recorded. FRAX risks of the patients will be calculated, and it will be examined whether they have any previous fracture history and whether they have received treatment for osteoporosis.

Eligibility criteria: Inclusion Criteria:

Being registered for home health services Having made a call to home health services in the last 6 months

Exclusion Criteria:

Patients that have passed away

Primary outcomes:
measure: Osteoporotic fracture risk of home care patients
timeFrame: 3 months
Secondary outcomes:
Other outcomes:
Locations:
city: Istanbul
country: Turkey
facility: Üsküdar State Hospital
state: Üsküdar
Study officials:
References:
Clinical trial NCT01936285: Colchicine in ST-elevation Myocardial Infarction
Official title: Study of Anti-inflammatory Treatment With Colchicine in the Acute Phase of ST-elevation Myocardial Infarction to Reduce Infarct Size
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: PHASE4
Conditions: Acute Myocardial Infarction
Lead sponsor: G.Gennimatas General Hospital
Sponsor class: OTHER
First posted: 2013-09-06
Enrollment: 150
Sex: ALL
Maximum age (years): 80
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: * There is evidence that inflammatory processes may play detrimental role during the acute phase of myocardial infarction
* The hypothesis of this study is that colchicine, by its anti-inflammatory action, may lead to reduction in infarct size, when administered during the acute phase of myocardial infarction


Eligibility criteria: Inclusion Criteria:

The study will enroll patients 18 years old or older who present to the hospital within twelve (12) hours of the onset of chest pain and who had ST segment elevation \>1 mm in two contiguous limb leads or ST segment elevation \>2 mm in two consecutive precordial leads or new onset of left bundle branch block (LBBB) in a twelve lead electrocardiogram and for whom the decision was made to be taken to the cath lab to perform angioplasty of the coronary vessels.

Excluded patients:

* \> 80 years old
* with active inflammatory diseases, infectious diseases or known malignancy
* under treatment with corticosteroids, anti-inflammatory agents or disease modifying agents
* with known hypersensitivity-allergy to colchicine
* under chronic treatment with colchicine
* with severe renal failure (eGFR \< 30 ml/min/1.73 m2)
* with hepatic failure (Child - Pugh class B or C)
* presenting with cardiac arrest
* presenting with ventricular fibrillation
* presenting with cardiogenic shock
* with stent thrombosis
* with angina within 48 hours before infarction
* with previous myocardial infarction
* with occlusion of the left main or left circumflex coronary artery or with evidence of coronary collaterals to the region at risk on initial coronary angiography (at the time of admission)
* with metallic implants (ferromagnetic material)

Primary outcomes:
measure: Infarct size on MRI
timeFrame: 5 days post-MI
measure: AUC CK-MB concentration
timeFrame: 0-3 days post-MI
Secondary outcomes:
measure: Myocardial damage marker levels
timeFrame: Days 1-3 post-MI
Other outcomes:
Locations:
city: Athens
country: Greece
facility: Athens General Hospital "G. Gennimatas"
Study officials:
References:
citation: Deftereos S, Giannopoulos G, Angelidis C, Alexopoulos N, Filippatos G, Papoutsidakis N, Sianos G, Goudevenos J, Alexopoulos D, Pyrgakis V, Cleman MW, Manolis AS, Tousoulis D, Lekakis J. Anti-Inflammatory Treatment With Colchicine in Acute Myocardial Infarction: A Pilot Study. Circulation. 2015 Oct 13;132(15):1395-403. doi: 10.1161/CIRCULATIONAHA.115.017611. Epub 2015 Aug 11.
Clinical trial NCT06175585: Construction of Theoretical Model of Medical Treatment Behavior of Patients With Chronic Kidney Disease
Official title: Construction of a Theoretical Model of Medical Behavior of Patients With Chronic Kidney Disease From the Perspective of Supply: An Empirical Analysis Based on Andersen Behavior Model
Study type: OBSERVATIONAL
Overall status: RECRUITING
Conditions: Narrative Nursing
Maintenance Hemodialysis
Chronic Kidney Diseases
Keywords: self-efficacy
negative emotions
life quality
Lead sponsor: Shanxi Medical University
Sponsor class: OTHER
First posted: 2023-12-19
Enrollment: 80
Sex: ALL
Minimum age (years): 18
Maximum age (years): 70
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: Patients undergoing MHD at the Department of Nephrology in our hospital.

Brief summary: The impact of narrative nursing interventions on negative emotions, self-efficacy, quality of life in individuals undergoing maintenance hemodialysis

Detailed description: The objective of this study is to create a narrative nursing protocol using the "two-line system" approach to enhance the practice of narrative nursing.Investigators applied this protocol during maintenance hemodialysis (MHD) treatment, with the aim of examining the impact of the interventions on negative emotions, self-efficacy, and overall quality of life of patients. By analyzing the data before and after the interventions, investigators aim to demonstrate how targeted narrative nursing measures can positively influence negative emotions, self-efficacy, and life quality of patients.

Eligibility criteria: Inclusion criteria:

* Patients diagnosed with ESRD and treated with dialysis for more than 3 months;
* Patients aged ≥18 years old;
* Patients with complete clinical data;
* Patients who are clearly conscious and can accurately express their willingness;
* Patients who have signed informed consent and are willing to cooperate with the study.

Exclusion criteria:

* Patients with other serious systemic diseases, such as severe cardiovascular and cerebrovascular diseases, severe diabetes, etc.;
* Patients with mental disorder, such as cognitive or intellectual disability;
* Patients with a history of anxiety and depression;
* Patients with intermittent loss of consciousness or are unable to understand the questions in the questionnaire.

Primary outcomes:
measure: Zung's Self-Rating Anxiety Scale
timeFrame: one week
measure: Self-rating Depression Scale
timeFrame: one week
Secondary outcomes:
Other outcomes:
Locations:
city: Taiyuan
country: China
facility: The Second Hospital of Shanxi Medical University
state: Shanxi
Study officials:
References:
Clinical trial NCT05892185: Evaluate the Efficacy and Safety of Glaucoma Implant in Primary Open Angle Glaucoma
Official title: A Randomized, Single-blind, Parallel Group Study to Evaluate the Efficacy and Safety of Glaucoma Implant in Primary Open Angle Glaucoma.
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Glaucoma
Keywords: Glaucoma Implant
Lead sponsor: Mingche Biotechnology CO., LTD
Sponsor class: INDUSTRY
First posted: 2023-06-07
Enrollment: 20
Sex: ALL
Minimum age (years): 18
Maximum age (years): 75
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The objective of this study is to evaluate the efficacy and safety of glaucoma device in the treatment of primary open-angle glaucoma.

Detailed description: A prospective, randomized, single-blind, positive control design was used to study primary open-angle glaucoma. Eligible subjects were screened and randomly assigned to the experimental group and the control group.

Eligibility criteria: Inclusion Criteria

* Patients with a clinical diagnosis of primary open-angle glaucoma (POAG) who could undergo minimally invasive glaucoma surgery (MIGS) as judged by the investigator.

Primary outcomes:
measure: Success rate at 6 months after surgery
timeFrame: 6 months
Secondary outcomes:
measure: IOP reduction
timeFrame: 6 months
measure: topical IOP-lowering medications
timeFrame: 6 months
measure: Success rate 12 months after operation
timeFrame: 12 months
measure: Adverse event
timeFrame: 12 months
Other outcomes:
Locations:
Study officials:
References:
Clinical trial NCT04982185: Neuromuscular Block Monitoring During Monitored Thyroidectomy
Official title: The Feasibility of Routine Neuromuscular Block Monitoring During Monitored Thyroidectomy- A Retrospective Review
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Thyroid Surgery
Keywords: intraoperative neuromonitoring (IONM)
thyroid surgery
neuromuscular block (NMB)
Lead sponsor: Kaohsiung Medical University Chung-Ho Memorial Hospital
Sponsor class: OTHER
Collaborators: name: Kaohsiung Medical University
First posted: 2021-07-29
Enrollment: 116
Sex: ALL
Minimum age (years): 20
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: CASE_CONTROL
Time perspective: RETROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: In a tertiary medical center and a regional teaching hospital

Brief summary: Titration of neuromuscular block (NMB) plays a key role in intraoperative recurrent laryngeal nerve monitoring during thyroid surgery. Aim to titrate sugammadex dose based on neuromuscular block degree as a surgeon friendly protocol with high intraoperative neuromonitoring (IONM) quality.


Eligibility criteria: Inclusion Criteria:

* elective monitored thyroidectomy

Exclusion Criteria:

* previous thyroid surgery
* preexisting vocal cord palsy

Primary outcomes:
measure: Feasibility in neural monitoring
timeFrame: through surgery completion, an average of 2 hours
Secondary outcomes:
measure: Quality of surgical relaxation
timeFrame: through surgery completion, an average of 2 hours
Other outcomes:
Locations:
city: Kaohsiung
country: Taiwan
facility: I-Cheng Lu
state: Select
Study officials:
References:
Clinical trial NCT06621485: Calculator Predicts Early Mortality Post Hepatocellular Carcinoma Resection
Official title: Multi-institutional Development and Validation of an Individualized Online Calculator for Early Mortality Risk After Hepatectomy Among Patients With Hepatocellular Carcinoma
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: To Predict Early Post-hepatectomy Mortality for HCC
Keywords: Hepatocellular carcinoma
Hepatectomy
Survival
Morbidity
Futile surgery
Lead sponsor: Beijing Tsinghua Chang Gung Hospital
Sponsor class: OTHER
Collaborators: name: Eastern Hepatobiliary Surgery Hospital of Shanghai
name: The First Hospital of Jilin University
name: Mengchao Hepatobiliary Hospital
name: The Fourth Affiliated Hospital of Harbin Medical University
name: Pu'er People's Hospital
name: Liuyang People's Hospital
name: Ziyang First People's Hospital
name: Qianfoshan Hospital
name: First Affiliated Hospital of Harbin Medical University
name: Fuyang people's hospital
First posted: 2024-10-01
Enrollment: 4966
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: CASE_CONTROL
Time perspective: RETROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: The final analytic cohort was comprised of 4,966 HCC patients treated with hepatectomy with curative intent across 11 hospitals; 3,433 patients were in the 9-center training cohort and 1,533 in the 2-center external validation cohort.

Brief summary: Using the multicenter data, we developed and validated an individualized online calculator to predict early mortality after liver resection for hepatocellular carcinoma. The user-friendly tool with 6 preoperative predictors demonstrated excellent accuracy. The freely available calculator may help identify high-risk patients and reduce futile liver resection for hepatocellular carcinoma.


Eligibility criteria: Inclusion Criteria:

Adults (age ≥18 years) who underwent curative-intent hepatectomy for newly diagnosed HCC.

HCC diagnosis was confirmed histopathologically.

Exclusion Criteria:

Patients undergoing emergency hepatectomy for tumor rupture, as well as individuals with recurrent HCC, and those with missing survival data or less than 90 days of follow-up were excluded.

Primary outcomes:
measure: 90-day death
timeFrame: The period starts from the day of the hepatectomy surgery and extends up to the 90th day post-surgery.
Secondary outcomes:
Other outcomes:
Locations:
city: Beijing
country: China
facility: Beijing Tsinghua Changgung Hospital
Study officials:
References:
Clinical trial NCT04464785: CentriMag Failure-to-Wean Post Approval Study
Official title: CentriMag Failure-to-Wean Post-Approval Study
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Heart Failure
Lead sponsor: Abbott Medical Devices
Sponsor class: INDUSTRY
First posted: 2020-07-09
Enrollment: 32
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Male and female subjects who fail-to-wean from cardiopulmonary bypass.

Brief summary: The primary objective of this Post Approval Study is to report the proportion of patients surviving to 30 days post CentriMag support or to hospital discharge, whichever is longer. For subjects who do not recover and are bridged to a heart transplant or a long-term assist device, the primary endpoint is survival to induction of anesthesia for the surgery.


Eligibility criteria: Inclusion Criteria:

* Subject \>18 years of age
* Subject or legal representative has signed Informed Consent Form (ICF)
* Subject has CentriMag Circulatory Support System implanted due to Failure To Wean from Cardiopulmonary Bypass

Exclusion Criteria:

• Concomitant use of Extracorporeal Membrane Oxygenation (ECMO) during CentriMag Circulatory Support System implantation due to FTW from CPB

Primary outcomes:
measure: Survival to 30 days Post CentriMag support or to hospital discharge
timeFrame: 30 days
measure: Survival to induction of anesthesia for surgery for transplant or a long-term system
timeFrame: Approximately 30 days
Secondary outcomes:
Other outcomes:
Locations:
city: Little Rock
country: United States
facility: Baptist Healt Medical Center
state: Arkansas
city: Atlanta
country: United States
facility: Emory University Hospital
state: Georgia
city: Oak Lawn
country: United States
facility: Advocate Christ Medical Center
state: Illinois
city: Ann Arbor
country: United States
facility: University of Michigan
state: Michigan
city: Minneapolis
country: United States
facility: University of Minnesota Medical Center Fairview
state: Minnesota
city: Saint Louis
country: United States
facility: Barnes Jewish Hospital
state: Missouri
city: Salt Lake City
country: United States
facility: University of Utah
state: Utah
city: Milwaukee
country: United States
facility: Medical College of Wisconsin
state: Wisconsin
Study officials:
affiliation: Abbott
name: Brian Crowe
role: STUDY_DIRECTOR
References:
Clinical trial NCT03962985: Effects of Montreal Museum of Fine Arts Visits and Older Community Dwellers With a Precarious State
Official title: Effects of Montreal Museum of Fine Arts Visits and Older Community Dwellers With a Precarious State: An Experimental Study
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Well Aging
Health Impairment
Social Isolation
Old Age
Lead sponsor: Jewish General Hospital
Sponsor class: OTHER
First posted: 2019-05-24
Enrollment: 41
Sex: ALL
Minimum age (years): 65
Standard ages: OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: OTHER

Brief summary: This study evaluates the effects of MMFA visits on psychological, health, social conditions and personal interactions in older community dwellers with a precarious state and to determine whether these effects may change precarity.

Detailed description: Precarity is a vulnerable state exposing individuals to adverse health, psychological social events. Older adults are exposed to precarity, especially those who were the old generation of immigrants in Canada. Art-based activities have also been proposed to community dwellers and have shown positive effects on health outcomes and are determinants for well-being with aging. The effects of participatory art-based activities on precarity in older adults have never been examined. Recently, the Montreal Museum of Fine Arts (MMFA) developed a new participatory art-based activity which is a 3 month-period of weekly museum visits for precarious populations.

Eligibility criteria: Inclusion Criteria:

* Being 65 years and over;
* Precarious condition defined with a score ≥30 (/100)
* Having an Internet access with an electronic device (i.e.; laptop, computer, smartphone, tablet) as the repetitive assessments for this study will be performed on the web platform of the Centre of Excellence on Longevity of McGill University;
* Understanding and writing the different languages of the recruitment centre (i.e., French, English, Chinese.);
* Severe frail condition determined with the Centre of Excellence self-administered questionnaire (CESAM)
* Living in Montreal

Exclusion Criteria:

* A concomitant participation to another clinical trial;
* Participation in another art-based activity;
* Palliative care;
* Living in residence;
* Having a moderate to severe mobility impairment (i.e. using a walker, a wheelchair or being unable to walk alone 10m).

Primary outcomes:
measure: Precarious social conditions
timeFrame: 3 months
Secondary outcomes:
measure: Well-being
timeFrame: 3 months
Other outcomes:
Locations:
city: Montréal
country: Canada
facility: Jewish General Hospital
state: Quebec
Study officials:
affiliation: Jewish General Hospital
name: Olivier Beauchet, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT00049985: Heart Failure and Anemia
Official title: A Double-blind, Randomized, Placebo-controlled, Multicenter Study to Assess the Impact of Subcutaneous (SC) Darbepoetin Alfa Treatment on Exercise Tolerance in Subjects With Symptomatic Heart Failure (CHF) and Anemia.
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE2
Conditions: Heart Failure
Anemia
Lead sponsor: Amgen
Sponsor class: INDUSTRY
First posted: 2002-11-19
Enrollment: 300
Sex: ALL
Minimum age (years): 21
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The purpose of this study is to determine whether increasing hemoglobin concentration in patients with heart failure and anemia will improve the patients' functional status, including exercise tolerance and New York Heart Association (NYHA) classification.


Eligibility criteria: Inclusion Criteria: - At least 21 years of age - Symptomatic CHF for at least 3 months - Limited exercise tolerance on a treadmill - Reduced left ventricular ejection fraction - Stable heart failure medication - Hemoglobin concentration between 9.0 and 12.5 g/dL Exclusion Criteria: - Hypertension - Unstable angina pectoris or recent myocardial infarction - Likely to receive cardiac transplant - Unable to do cardiopulmonary exercise testing - Major organ transplant (e.g., lung, liver, heart) or in renal replacement therapy (e.g., dialysis) - Recent or current treatment for malignancy - Systemic hematologic disease - Anemia due to acute or chronic bleeding - Recent epogen or darbepoetin alfa therapy - Recent blood transfusion

Primary outcomes:
measure: Exercise tolerance
Secondary outcomes:
measure: NYHA classification; patient-reported outcomes
Other outcomes:
Locations:
Study officials:
affiliation: Amgen
name: MD
role: STUDY_DIRECTOR
References:
citation: Ghali JK, Anand IS, Abraham WT, Fonarow GC, Greenberg B, Krum H, Massie BM, Wasserman SM, Trotman ML, Sun Y, Knusel B, Armstrong P; Study of Anemia in Heart Failure Trial (STAMINA-HeFT) Group. Randomized double-blind trial of darbepoetin alfa in patients with symptomatic heart failure and anemia. Circulation. 2008 Jan 29;117(4):526-35. doi: 10.1161/CIRCULATIONAHA.107.698514. Epub 2008 Jan 14.