Clinical trial NCT05759832: Modified HFNC Therapy for ARF Patients Undergoing Flexible Bronchoscopy
Official title: Modified Nasal High-flow Oxygen Therapy for Acute Respiratory Failure Patients Undergoing Flexible Bronchoscopy
Study type: INTERVENTIONAL
Overall status: RECRUITING
Phase: NA
Conditions: Acute Hypoxemic Respiratory Failure
High-flow Nasal Cannula Oxygen
Lead sponsor: Beijing Chao Yang Hospital
Sponsor class: OTHER
First posted: 2023-03-08
Enrollment: 140
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: Acute respiratory failure (AFR) is a serious condition that requires prompt and appropriate intervention to prevent further deterioration and improve outcomes. Bronchoscopy is a commonly used diagnostic and therapeutic procedure in patients with respiratory failure. However, traditional low-flow oxygen supplementation during bronchoscopy may not provide adequate oxygenation and ventilation, leading to complications and worsening of the patient's condition.

High-flow nasal cannula therapy has improved oxygenation and ventilation in critically ill patients, making it a promising alternative to traditional oxygen supplementation during bronchoscopy. The bronchoscope is passed through the nose during all procedures in our center. HFNC oxygen therapy is applied to both nostrils. The bronchoscope occupies one of the nares receiving oxygen therapy during bronchoscopy. As a result, the application of HFNC needs to be optimized. Therefore, the investigators designed a modified HFNC with a single cannula. However, limited data exist on the safety and efficacy of modified HFNC therapy in patients with respiratory failure undergoing bronchoscopy.

Therefore, the aim of this study is to evaluate the impact of modified HFNC therapy on the outcomes of undergoing bronchoscopy in patients with ARF. The findings of this study will contribute to understanding the role of modified HFNC therapy in managing ARF and inform clinical practice.


Eligibility criteria: Inclusion Criteria:

1. Age ≥ 18 years old;
2. Bronchoscopy is required;
3. 150 mmHg ≤ PaO2/FiO2 \< 300 mmHg.

Exclusion Criteria:

1. Not tolerate HFNC oxygen therapy;
2. Obstruction of nasopharynx cavity;
3. Platelet\<60 × 109/L；
4. Need tracheal intubation;
5. The patient has received invasive ventilation.

Primary outcomes:
measure: Need to increase ventilatory support
timeFrame: Within 24 hours after bronchoscopy
Secondary outcomes:
measure: The incidence of hypoxia during bronchoscopy
timeFrame: During bronchoscopy
Other outcomes:
Locations:
city: Beijing
country: China
facility: Beijing Chao-Yang Hospital
state: Beijing
Study officials:
affiliation: Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China
name: Rui Wang, Dr.
role: STUDY_DIRECTOR
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