Clinical trial NCT05906693: The Quality of Life in Individuals With Parkinson's Disease
Official title: A Cross-sectional Study - The Quality of Life in Individuals With Parkinson's Disease: Is it Related to Functionality and Tremor Severity?
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Parkinson Disease
Tremor
Functionality
Keywords: Quality of Life
Upper Limb Functionality
Tremor
Electromyography
Parkinson's Disease
Lead sponsor: Pamukkale University
Sponsor class: OTHER
First posted: 2023-06-18
Enrollment: 52
Sex: ALL
Minimum age (years): 40
Maximum age (years): 80
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: CROSS_SECTIONAL
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Individuals with Parkinson Disease were included in the study

Brief summary: This study aimed to examine the relationship of quality of life with tremor severity and upper limb functionality in individuals with Parkinson's Disease. The differences between Parkinson's Disease Quality of Life Questionnaire, Nine-Hole Peg Test, grip and pinch strength values in the individuals with and without tremor in the study were investigated.

Detailed description: Evaluating the relationship between Quality of Life and tremor is needed to determine the best physiotherapy and rehabilitation approaches for individuals with Parkinson's Disease. This study aimed to examine the relationship of quality of life with tremor severity and upper limb functionality in individuals with Parkinson's Disease. Fifty-two individuals with Parkinson's Disease participated in the study. Quality of Life, tremor amplitude, upper limb functionality, grip and pinch strength were evaluated. The relationship of quality of life with tremor severity and upper limb functionality was examined in individuals with Parkinson's Disease. The results of individuals with and without tremor were compared.

Eligibility criteria: Inclusion Criteria:

* Definite diagnosis of idiopathic Parkinson Disease
* Age between 40 and 80 years
* Being literate
* Having a grade between 1-4 from the Modified Hoehn and Yahr Scale
* Having a score lower than 11 in Hospital Anxiety and Depression Scale

Exclusion Criteria:

* Who were with any other neurologic or orthopedic or rheumatologic disease affecting the upper extremity
* Using antidepressants
* Having vision loss
* Deep brain stimulation

Primary outcomes:
measure: Movement Disorder Society-Sponsored Revision of the Unified Parkinson's Disease Rating Scale
timeFrame: 1 year
measure: Hospital Anxiety and Depression Scale
timeFrame: 1 year
measure: Parkinson's Disease Quality of Life Questionnaire (PDQ-39)
timeFrame: 1 year
measure: Electromyography
timeFrame: 1 year
measure: Nine-Hole Peg Test
timeFrame: 1 year
measure: Dynamometer
timeFrame: 1 year
Secondary outcomes:
Other outcomes:
Locations:
city: Denizli
country: Turkey
facility: Pamukkale University
state: Pamukkale
Study officials:
affiliation: Pamukkale University
name: Buse KILINÇ, PT.MSc.
role: PRINCIPAL_INVESTIGATOR
affiliation: Pamukkale University
name: Nilüfer ÇETİŞLİ-KORKMAZ, PT.PhD.Prof.
role: STUDY_DIRECTOR
affiliation: Pamukkale University
name: Levent S. BIR, MD.PhD.Prof.
role: STUDY_CHAIR
affiliation: Klinikum Stuttgart
name: Ahmet D. MARANGOZ, MD.
role: STUDY_CHAIR
affiliation: Pamukkale University
name: Hande ŞENOL, Assist.Prof.
role: STUDY_CHAIR
References:
citation: Kuhlman GD, Flanigan JL, Sperling SA, Barrett MJ. Predictors of health-related quality of life in Parkinson's disease. Parkinsonism Relat Disord. 2019 Aug;65:86-90. doi: 10.1016/j.parkreldis.2019.05.009. Epub 2019 May 7.
citation: Bhatia KP, Bain P, Bajaj N, Elble RJ, Hallett M, Louis ED, Raethjen J, Stamelou M, Testa CM, Deuschl G; Tremor Task Force of the International Parkinson and Movement Disorder Society. Consensus Statement on the classification of tremors. from the task force on tremor of the International Parkinson and Movement Disorder Society. Mov Disord. 2018 Jan;33(1):75-87. doi: 10.1002/mds.27121. Epub 2017 Nov 30.
citation: Louis ED, Machado DG. Tremor-related quality of life: A comparison of essential tremor vs. Parkinson's disease patients. Parkinsonism Relat Disord. 2015 Jul;21(7):729-35. doi: 10.1016/j.parkreldis.2015.04.019. Epub 2015 Apr 24.