Clinical trial NCT03138109: Analysis of Incidence and Risk Factors of Severe Cardiovascular Events in Patients With Diastolic Dysfunction
Official title: Analysis of Incidence and Risk Factors of Severe Cardiovascular Events in Patients With Diastolic Dysfunction
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Diastolic Dysfunction
Keywords: non-cardiac surgery
major adverse cardiac event
Lead sponsor: Peking University First Hospital
Sponsor class: OTHER
First posted: 2017-05-03
Enrollment: 4347
Sex: ALL
Minimum age (years): 18
Maximum age (years): 100
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: OTHER
Time perspective: RETROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: patients with diastolic dysfunction

Brief summary: This retrospective cohort study was intended to analyze the incidence and risk factors of perioperative severe cardiovascular events in patients with diastolic dysfunction.

Detailed description: The investigators retrospected patients underwent noncardiac surgery with pre-operative echocardiography and was diagnosed with diastolic dysfunction in 2015 in Peking University First Hospital. Patients' perioperative data were collected. Major adverse cardiovascular events(MACE), other complication incidence, and post-operative hospital stay were reviewed. propotional harzad ratio cox survival model was established. Risk and protective factors relative to MACE were analysed.

Eligibility criteria: Inclusion Criteria:

* 18 years old or older, with echocardiographic diagnosis of left ventricular diastolic dysfunction (while ejection fraction was \> = 50%) conducted by cardiologist within 90 days before surgery.

Exclusion Criteria:

* congenital heart disease, moderate to severe valvular disease (stenosis or insufficiency), atrial fibrillation / atrial flutter, pericarditis, unsatisfied cardiac ultrasound image, ejection fraction \< 50%, ASA greater than 4, or Echocardiography is missing or incomplete.

Primary outcomes:
measure: MACE
timeFrame: 30 days
Secondary outcomes:
Other outcomes:
Locations:
city: Beijing
country: China
facility: First hospital Peking University
state: Beijing
Study officials:
affiliation: Peking University First Hospital
name: Yan Zhou, MD, PhD
role: PRINCIPAL_INVESTIGATOR
References:
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citation: Fayad A, Ansari MT, Yang H, Ruddy T, Wells GA. Perioperative Diastolic Dysfunction in Patients Undergoing Noncardiac Surgery Is an Independent Risk Factor for Cardiovascular Events: A Systematic Review and Meta-analysis. Anesthesiology. 2016 Jul;125(1):72-91. doi: 10.1097/ALN.0000000000001132.
citation: Devereaux PJ, Goldman L, Yusuf S, Gilbert K, Leslie K, Guyatt GH. Surveillance and prevention of major perioperative ischemic cardiac events in patients undergoing noncardiac surgery: a review. CMAJ. 2005 Sep 27;173(7):779-88. doi: 10.1503/cmaj.050316.