louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT06821971: Study of Risk Factors for Therapeutic Failure in Chronic Non-Infectious Uveitis After First-Line Immunosuppressive Therapy
Official title: Study of Risk Factors for Therapeutic Failure in Chronic Non-Infectious Uveitis After First-Line Immunosuppressive Therapy
Study type: OBSERVATIONAL
Overall status: ACTIVE_NOT_RECRUITING
Conditions: Uveitis
Keywords: Uveitis
Lead sponsor: Centre Hospitalier Universitaire, Amiens
Sponsor class: OTHER
First posted: 2025-02-12
Enrollment: 200
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: OTHER
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Retrospective cohort study based on medical records of patients who received first-line immunosuppressive (IS) therapy for their uveitis. Patients with chronic non-infectious uveitis at Amiens-Picardie University Hospital, over the period from January 2013 to January 2023.

Brief summary: Uveitis is an inflammatory disease of the uvea, constituting the 4th leading cause of legal blindness worldwide and the 3rd leading cause of avoidable blindness . It is not a rare condition, with an incidence of 17 to 52 per 100,000 population and a prevalence of 38 to 204 per 100,000 population. In the case of cortico-dependence, it is generally accepted to propose sparing with a conventional immunosuppressant, whose efficacy is estimated at around 70%, compared with biotherapies, which are considered more effective (over 90%) but only available as 2nd-line treatment. However, there are few studies on the failure factors of this first-line treatment, such as macular thickness , gender, or vitamin D deficiency. Risk factors for flare-ups are nevertheless known, notably ethnicity, and smoking. The aim of this study is to identify risk factors for treatment failure after three months of first-line immunosuppressive therapy in patients with chronic non-infectious uveitis at Amiens-Picardie University Hospital.


Eligibility criteria: Inclusion Criteria:

* Age : \> 18 years old
* Uveitis requiring immunosuppressive therapy.
* Including at least one posterior involvement according to the SUN terminology: posterior, or intermediate and posterior, or anterior and posterior, or panuveitis.

Exclusion Criteria:

* Uveitis associated with multiple sclerosis or systemic lupus erythematosus.
* Ocular involvement in Behcet's disease requiring biologic therapy as first-line immunosuppressive treatment.
* Uveitis without posterior segment involvement.
* Infectious uveitis.
* Patients objecting to the use of their personal data for research purposes.

Primary outcomes:
measure: Number of therapeutic failure at 4 months
timeFrame: 4 months
Secondary outcomes:
measure: Number of therapeutic failure at 9 months
timeFrame: 9 months
Other outcomes:
Locations:
city: Salouel
country: France
facility: CHU Amiens-Picardie
Study officials:
References:
Clinical trial NCT02873871: Comparison of 2 Hemostasis Techniques After Transradial Coronary
Official title: Effect of Two Compression Devices on the Occurrence of Artery Occlusion After Transradial Cardiac Catheterization: Randomized Clinical Trial
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Coronary Artery Disease With Myocardial Infarction
Lead sponsor: Hospital de Clinicas de Porto Alegre
Sponsor class: OTHER
First posted: 2016-08-22
Enrollment: 600
Sex: ALL
Minimum age (years): 18
Maximum age (years): 70
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: Randomized clinical trial to compare radial artery patency after transradial coronary catheterization using 2 different hemostasis techniques. Patients submitted to diagnostic or therapeutic coronary catheterization will be prospectively enrolled in this single-center trial and will be randomized to radial hemostasis with TerumoBand® or a standardized compressive dressing with gauze and elastic bandage.

Detailed description: Randomized clinical trial to compare radial artery patency after transradial coronary catheterization using 2 different hemostasis techniques. Patients submitted to diagnostic or therapeutic coronary catheterization will be prospectively enrolled in this single-center trial and will be randomized to radial hemostasis with TerumoBand® or a standardized compressive dressing with gauze and elastic bandage.

Interventions: Radial hemostasis with TerumoBand® and Radial hemostasis with a standardized compressive dressing

Eligibility criteria: Inclusion Criteria:

* Adult patients submitted to elective or urgent coronary catheterization who presented with a A, B or C curve on oximetry test before the procedure

Exclusion Criteria:

* Inability to understand the study and sign the informed consent form

Primary outcomes:
measure: Radial artery occlusion evaluated using Barbeau's test
timeFrame: up to 3 hours
Secondary outcomes:
measure: Vascular complications
timeFrame: up to 3 hours
measure: Radial access site pain
timeFrame: up to 3 hours
Other outcomes:
Locations:
city: Porto Alegre
country: Brazil
facility: Universidade Federal do Rio Grande do Sul - Post Graduated Program
state: Rio Grande Do Sul
Study officials:
affiliation: Hospital de Clinicas de Porto Alegre
name: Eneida Rejane Rabelo da Silva, RN, MSc, ScD
role: STUDY_CHAIR
References:
Clinical trial NCT04710771: Effect of Prone Positioning in Patients With COVID-19
Official title: Effect of Prone Positioning and Alternate Nostril Breathing Technique in Patients With COVID-19: A Quasi Experimental Study.
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Covid19
Keywords: Covid-19
General Anxiety Disorder-7
Prone Position
Alternate Nostril Breathing
Lead sponsor: Sialkott College of Physical Therapy
Sponsor class: OTHER
First posted: 2021-01-15
Enrollment: 30
Sex: ALL
Minimum age (years): 40
Maximum age (years): 80
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NON_RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: COVID-19 is affecting the people around the world and the infected individuals' may either stay asymptomatic or present to hospitals with severe distress and life threatening symptoms. The objective of the study is to investigate role of Prone positioning and alternate nostril breathing in patients with Covid-19.

Detailed description: In this quasi experimental study, 30 patients aged 40-80 years of either gender with a confirmed diagnosis of COVID-19 receiving supplemental oxygen were recruited from DHQ Hospital Faisalabad. patients were grouped into two A \& B. We collected baseline data on demographics and anthropometrics. After baseline data collection, all the patients were helped into the prone position, which was maintained for a minimum duration of three hours. After that patients in group B performed alternate nostril breathing for 10 minutes with help of physiotherapist. Clinical data were re-collected on 3rd day of intervention one hour after returning to the supine position in group A and after alternate nostril breathing in group B. The main study outcome was the variation in oxygenation (partial pressure of oxygen \[PaO2\]/ fractional concentration of oxygen in inspired air \[FiO2\]) between baseline and resupination, and General psychological state through GAD-7 General anxiety disorder questionnaire.

Eligibility criteria: Inclusion Criteria:

Age: 40-80 Gender: Both GCS score:15

Exclusion Criteria:

* COPD Intubated ARDS Smoker Neurological Disorder

Primary outcomes:
measure: PaO2
timeFrame: Change in score before the intervention on 1st day of intervention and on 3rd day one hour after the intervention.
measure: FiO2
timeFrame: Change in score before the intervention on 1st day of intervention and on 3rd day one hour after the intervention.
measure: General Anxiety Disorder-7 Score
timeFrame: Change in score before the intervention on 1st day of intervention and on 3rd day one hour after the intervention.
Secondary outcomes:
Other outcomes:
Locations:
city: Faisalabad
country: Pakistan
facility: DHQ Hospital
state: Punjab
Study officials:
affiliation: Independent Medical College, Faisalabad
name: Sahreen Anwar, PhD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT05817071: Results of Arthroscopic Massive Rotator Cuff Tears Repair With or Without Using Long Head of Biceps Tendon
Official title: Results of Arthroscopic Massive Rotator Cuff Tears Repair With Or Without Superior Capsular Augmentation Using Proximal Part Of Long Head Of Biceps Tendon: A Randomized Controlled Trial
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Rotator Cuff Tears
Keywords: Massive cuff tears
Biceps autograft
Arthroscopic repair partial or complete
Retear
Superior capsular augmentation
Lead sponsor: Ain Shams University
Sponsor class: OTHER
First posted: 2023-04-18
Enrollment: 30
Sex: ALL
Minimum age (years): 40
Maximum age (years): 80
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The Goal of this clinical trial is to asses the function of arthroscopic repair with or without superior capsular augmentation using biceps tendon .

Detailed description: All patients included in this clinical trial Will be informed by written consent will undergo a one week screening to determine the eligibility for study entry. Patients who meet the eligibility requirements Will be randomised in a single blinded manner ( patients).

Eligibility criteria: Inclusion Criteria:

* age 40 to 80 years old
* Patients with massive rotator cuff tear

Exclusion Criteria:

* patients with glenohumeral arthritis
* Acromioclavicular arthritis that requires distal clavicle resection
* Patients with other intra articular pathology like slap lesion
* Neural damage( brachial plexus injury)
* Revision cases

Primary outcomes:
measure: Functional shoulder constant score (assess the change pre operative and post operative during study period completion)
timeFrame: 1- preoperative 2- six months post operative 3- one year post operative
measure: Functional shoulder ases score (assess the change preoperative and postoperative during study period completion )
timeFrame: 1- preoperative 2- six months post operative 3- one year post operative
Secondary outcomes:
measure: Shoulder Pain ( assess the change preoperative and postoperative during the study period completion)
timeFrame: 1 pre operative 2 two weeks post operative 3 six months post operative
Other outcomes:
Locations:
city: Cairo
country: Egypt
facility: Mostafa Ahmed Mohamed Mostafa,MSC
state: Abbasia
Study officials:
affiliation: Faculty of medicine Ain shams university
name: Amr Mo Abdelhady, Professor
role: STUDY_CHAIR
affiliation: Faculty of medicine Ain shams university
name: Mohamed Ha Sobhy, Professor
role: STUDY_DIRECTOR
affiliation: Faculty of medicine Ain shams university
name: Ahmed Ha Khater, professor
role: STUDY_DIRECTOR
affiliation: Faculty of medicine Ain shams university
name: Yahia Mo Haroun, Lecturer
role: STUDY_DIRECTOR
affiliation: Faculty of medicine Ain shams university
name: Mostafa Ah Mostafa
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT00869271: Postoperative Folfox4 Only Versus Folfox4 Plus Transhepatic Arterial Chemotherapy (TAC) in the Treatment Unresectable Liver Metastasis of Colorectal Cancer
Official title: Postoperative folfox4 Only vs folfox4 Plus TAC in the Treatment Unresectable Liver Metastasis of Colorectal Cancer: a Randomized,Prospective,Control Trial
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE4
Conditions: Unresectable Liver Metastasis of Colorectal Cancer
Keywords: liver metastasis
colorectal cancer
Lead sponsor: Fudan University
Sponsor class: OTHER
First posted: 2009-03-25
Enrollment: 200
Sex: ALL
Minimum age (years): 18
Maximum age (years): 75
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The purpose of this study is to investigate whether TAC plus FOLFOX4 are able to improve resection rate and overall survival in patients receiving primary colorectal tumor resection than given FOLFOX4 only.

Detailed description: We administered three cycles FOLFOX4 plus on TAC (oxaliplatin, FUDR and MMC) or FOLFOX4 only to primary colorectal tumor resected patients with unresected liver metastasis. The study endpoints were resection rate of liver metastasis, progression-free survival, overall survival as evaluated by intent-to-treat analysis.

Eligibility criteria: Inclusion Criteria:

* age \< 75 years with histologically proven adenocarcinoma of the colon or rectum
* no severe major organ dysfunction
* WHO performance status of 0 or 1
* no prior cancer therapy
* with measurable unresectableliver metastasis
* without other metastasis

Exclusion Criteria:

* age \>= 75
* severe major organ dysfunction
* WHO performance status of \>1
* prior cancer therapy
* with other metastasis

Primary outcomes:
measure: overall survival
timeFrame: 5 years after diagnosis
Secondary outcomes:
measure: progression free survival
timeFrame: 5 years after diagonsis
Other outcomes:
Locations:
city: Shanghai
country: China
facility: Zhongshan Hospital, Fudan University
state: Shanghai
Study officials:
affiliation: department of general surgery, zhongshan hospital, fudan university
name: jianmin xu, MD, PHD
role: STUDY_DIRECTOR
References:
Clinical trial NCT06456671: Examining the Generality of Laboratory-based Findings and Their Moderators in the ITC Study
Official title: Examining the Generality of Laboratory-based Findings and Their Moderators Using Diverse Samples From the International Tobacco Control (ITC) Policy Evaluation Project Cohorts - Study 3a
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Cigarette Smoking
Nicotine Vaping
Lead sponsor: Virginia Polytechnic Institute and State University
Sponsor class: OTHER
Collaborators: name: Medical University of South Carolina
name: University of Waterloo
name: National Cancer Institute (NCI)
First posted: 2024-06-13
Enrollment: 443
Sex: ALL
Minimum age (years): 21
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: CROSSOVER
Intervention model description: Participants will complete seven Experimental Tobacco Marketplace conditions. Conventional cigarette price will be parametrically increased, and the purchasing of alternative products measured. Alternative products (i.e. nicotine vaping products, heated tobacco products and nicotine pouches) will be available at different prices in separate conditions (i.e., ½ market price and market price).
Primary purpose: BASIC_SCIENCE

Brief summary: This study will investigate the relative appeal (abuse liability) of novel tobacco products, how the appeal is modulated by relative price, user type, and how novel products may substitute for one another.

Detailed description: An important aim of tobacco control is to reduce demand for the most harmful products. Therefore, a priori knowledge of substitutability across novel and widely used tobacco products may forecast the impact of policies on product switching. This study will use a novel method, the Experimental Tobacco Marketplace (ETM), to characterize the relative substitutability and appeal (abuse liability) of tobacco products (e.g., conventional cigarettes, nicotine vaping products \[NVP\], heated tobacco products \[HTP\], and nicotine pouch products \[NPP\]), and how the appeal is modulated by relative price, user type, and regulatory environment. Exclusive cigarette smokers and dual cigarette/NVP users, stratified by age, will complete multiple scenarios in the ETM.

Eligibility criteria: Inclusion Criteria:

* From CA, US, or EN
* At least 21 years old
* Smoking daily
* Smoking mostly or about equal amounts of factory-made cigarettes
* Does not currently vape (for exclusive smokers only)
* Vapes Daily (for dual users only)

Exclusion Criteria:

* There will be no additional exclusion criteria for this study.

Primary outcomes:
measure: Cigarette demand
timeFrame: 1 day
measure: Nicotine/tobacco products substitution
timeFrame: 1 day
Secondary outcomes:
Other outcomes:
Locations:
city: Roanoke
country: United States
facility: Fralin Biomedical Research Institute
state: Virginia
Study officials:
affiliation: Fralin Biomedical Research Institute at VTC
name: Warren K Bickel, Ph.D.
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT01862471: Neuromuscular Electrical Stimulation Versus Intermittent Pneumatic Compression for Blood Flow
Official title: Improved Lower Limb Haemodynamics Using Neuromuscular Electrical Stimulation (NMES); Potential Novel DVT Prophylaxis
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Venous Thrombosis
Keywords: Deep Vein Thrombosis
Neuromuscular Electrical Stimulation
Intermittent Pneumatic Compression
Doppler Ultrasound
Lead sponsor: National University of Ireland, Galway, Ireland
Sponsor class: OTHER
Collaborators: name: Irish Research Council
First posted: 2013-05-24
Enrollment: 30
Sex: ALL
Minimum age (years): 18
Maximum age (years): 40
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: PREVENTION

Brief summary: Deep Vein Thrombosis (DVT) is a life threatening condition and a serious concern among hospitalized patients, with death occurring in approximately 6% of cases. It involves the formation of a clot where stagnant blood flow occurs, predominantly in the deep veins of the legs. Three mechanisms underlie DVT, venous stasis (slowing or stopping of the blood), hypercoagulability (increased clotting) and damage to blood vessel endothelium (damage to blood vessel wall), collectively known as Virchow's triad.

Intermittent pneumatic compression (IPC) and neuromuscular electrical stimulation (NMES) have been shown to improve lower limb blood flow. However, few studies have directly compared the two methods and those that have, have used outdated NMES devices.

The objective of this study is to compare the effectiveness of a modern NMES device to intermittent pneumatic compression in terms of blood flow.


Eligibility criteria: Inclusion Criteria:

-

Exclusion Criteria:

* History of heart/respiratory problems
* Pregnancy
* Presence of implants, including cardiac pacemakers and orthopaedic implants
* History of neurological disorder
* History of severe arterial disease or known dermatological problems
* Under 18 years of age or over 40 years of age

Primary outcomes:
measure: Blood Flow Measurements from the Lower Limb
timeFrame: An hour and a half (plus or minus half an hour)
Secondary outcomes:
measure: Blood Pressure
timeFrame: An hour and a half (plus or minus half an hour)
measure: Heart Rate
timeFrame: An hour and a half (plus or minus half an hour)
Other outcomes:
Locations:
city: Galway
country: Ireland
facility: National University of Ireland, Galway
Study officials:
affiliation: National University of Ireland, Galway
name: Gearoid OLaighin, PhD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT04452071: Gingival Crevicular Fluid Alkaline Phosphatase as Skeletal Growth Indicator
Official title: Gingival Crevicular Fluid Alkaline Phosphatase Activity as a Biomarker of Skeletal Maturation in Comparison to Modified Middle Phalanx of The Middle Finger (MP3) Method in a Sample of Growing Egyptian Females
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Growth Indictaor
Lead sponsor: Cairo University
Sponsor class: OTHER
First posted: 2020-06-30
Enrollment: 92
Sex: FEMALE
Minimum age (years): 7
Maximum age (years): 16
Standard ages: CHILD
Observational model: COHORT
Time perspective: CROSS_SECTIONAL
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Egyptian female patients with age range from 7 to 16 years old

Brief summary: Determination of the pubertal growth spurt in Egyptian female patients using gingival crevicular fluid alkaline phosphatase

Detailed description: assessment of the pubertal growth spurt in growing Egyptian female patients by using a simple, quick and easy method, through taking a gingival crevicular fluid alkaline phosphatase sample and measuring its concentration. Comparing the concentration of GCF ALP to the standardized middle phalanax of the middle finger MP3 we can predict if it can be an accurate and reliable method as skeletal growth indicator.

Eligibility criteria: Inclusion Criteria:

1. Gender: only female subjects will be included.
2. Age between 7-16 years old
3. Intermediate or late mixed dentition and permanent dentition
4. Good general health with absence of any nutritional problems or bony disease
5. No usage of any anti-inflammatories or antibiotics in the month preceding the study
6. Fully erupted upper and lower central incisors for sample collection
7. Good gingival and periodontal health as indicated by Probing depth (PD) values that should not exceed 3 mm for the whole dentition.
8. Willingness to participate in the study and sign the informed consent form

Exclusion Criteria:

1. Male adolescent subjects
2. Periodontal and /or gingival disease
3. Systemic and/or bone disease

3. Growth abnormality

Primary outcomes:
measure: GCF ALP concentration
timeFrame: immediately after sample collection
measure: MP3
timeFrame: immediately after taking x-rays
Secondary outcomes:
Other outcomes:
Locations:
city: Cairo
country: Egypt
facility: Faculty of Dentistry
state: Manial
Study officials:
References:
citation: Perinetti G, Baccetti T, Contardo L, Di Lenarda R. Gingival crevicular fluid alkaline phosphatase activity as a non-invasive biomarker of skeletal maturation. Orthod Craniofac Res. 2011 Feb;14(1):44-50. doi: 10.1111/j.1601-6343.2010.01506.x. Epub 2010 Nov 23.