Clinical trial NCT04849728: A Phase 3 Study Evaluating Efficacy and Safety of Lanifibranor Followed by an Active Treatment Extension in Adult Patients With (NASH) and Fibrosis Stages F2 and F3 ( NATiV3 )
Official title: A Randomised, Double-blind, Placebo-controlled, Multicentre, Phase 3 Study Evaluating Efficacy and Safety of Lanifibranor Followed by an Active Treatment Extension in Adult Patients With Non-cirrhotic Non-alcoholic Steatohepatitis (NASH) and Fibrosis Stages F2 and F3
Study type: INTERVENTIONAL
Overall status: RECRUITING
Phase: PHASE3
Conditions: NASH - Nonalcoholic Steatohepatitis
Keywords: Phase III
Nonalcoholic Steatohepatitis
NASH
Peroxisome proliferator-activated receptor (PPAR)
Liver Diseases
Fibrosis
Lead sponsor: Inventiva Pharma
Sponsor class: INDUSTRY
First posted: 2021-04-19
Enrollment: 1000
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: This Phase 3 study is conducted to evaluate lanifibranor in adults with NASH and liver fibrosis histological stage F2 or F3

Detailed description: Primary objectives

This Phase 3 study is conducted to evaluate lanifibranor in adults with NASH and liver fibrosis stage F2 or F3 and consists of 2 sequential parts - an initial double-blind placebo-controlled (DBPC) period (Part A) followed by a double-blind active treatment extension (ATE) period (Part B), with the following primary objectives:

Part A To assess the safety and efficacy of lanifibranor compared to placebo on 'NASH resolution and improvement of fibrosis' assessed by liver histology.

Part B To assess the safety of lanifibranor beyond the DBPC period. Secondary objectives

Key secondary objectives of Part 1:

* To assess the effect of lanifibranor compared to placebo on NASH resolution and no worsening of fibrosis
* To assess the effect of lanifibranor compared to placebo on improvement of fibrosis with no worsening of NASH

Other secondary objectives of both Part 1 and Part 2:

* To assess the effect of lanifibranor on other key histological features of NASH (only for DBPC period)
* To assess the effect of lanifibranor on NASH resolution and improvement of fibrosis in diabetic patients (only for DBPC period)
* To assess the effect of lanifibranor on liver tests
* To assess the effect of lanifibranor on glycaemic parameters
* To assess the effect of lanifibranor on lipid parameters
* To assess the effect of lanifibranor on liver stiffness and steatosis assessed by elastography.
* To assess the effect of lanifibranor on health-related quality of life
* To assess the safety of lanifibranor
* To assess population PK modeling through plasma levels of lanifibranor using sparse sampling scheme (only for DBPC period)

Eligibility criteria: Prescreening Criteria:

* Diagnosed with NASH on prior liver biopsy
* Type 2 diabetes with high waist circumference or obesity or hepatic steatosis on ultrasound
* At least 3 of the components of metabolic syndrome

Inclusion Criteria:

1. Male or female, aged ≥18 years at the time of signing informed consent
2. Upon central biopsy reading process: diagnosis of NASH according to the Steatosis-Activity-Fibrosis (SAF):

   1. Steatosis score ≥1
   2. Activity score: A3 or A4
   3. Fibrosis score: F2 or F3
3. No qualitative change in dose for the drugs listed below:

   1. Antidiabetic treatment if glucagon-like peptide-1 receptor agonists (GLP1 receptor agonists) or sodium-glucose co-transporter-2 inhibitors (SGLT2 inhibitors): for at least 3 months
   2. Vitamin E (if at a dose ≥400 IU/day): for at least 6 months
   3. Statins: for at least 3 months
4. No qualitative change in dose for all other chronically administered drugs for at least 3 months prior to Screening
5. Weight stable for 6 months prior to Screening and between the qualifying liver biopsy and Baseline (no more than 5% change for both periods)
6. Negative serum pregnancy test at study Screening for females of childbearing potential confirmed by central laboratory. Females of childbearing potential must practice a consistent and proper use of highly effective method of contraception throughout the study and for 1 month after treatment discontinuation.

Exclusion Criteria:

Liver-related:

1. Documented causes of chronic liver disease other than NASH
2. Histologically documented liver cirrhosis (fibrosis stage F4)
3. History or current diagnosis of hepatocellular carcinoma (HCC)
4. History of or planned liver transplant
5. Positive human immunodeficiency virus (HIV) serology
6. ALT or AST \>5 × ULN
7. AST\<0.6 ULN if the liver biopsy has to be performed in the scope of the study
8. Abnormal synthetic liver function as defined by Screening central laboratory evaluation
9. Haemoglobin \<110 g/L (11 g/dL) for females and \<120 g/L (12 g/dL) for males
10. Patient currently receiving any approved treatment for NASH or obesity
11. Current or recent history (\<5 years) of significant alcohol consumption
12. Treatment with drugs that may cause non-alcoholic fatty liver disease (NAFLD) administered for at least 2 weeks within 12 months prior to qualifying liver biopsy

    Glycaemia related:
13. HbA1c \>9% at Screening
14. Diabetes mellitus other than type 2
15. Current treatment with insulin
16. Treatment with PPAR-gamma agonists (thiazolidinediones \[TZDs\]) 12 months before screening or historical biopsy.

    Obesity related:
17. Bariatric surgery: Restrictive procedures are allowed, if performed \>6 months prior to the qualifying liver biopsy; malabsorptive procedures and procedures combining both restrictive and malabsorptive methods are not allowed within 5 years of the qualifying liver biopsy.

    Cardiovascular related:
18. History of heart failure with reduced left ventricular ejection fraction (LVEF)
19. Atrial fibrillation requiring anticoagulation
20. Unstable heart failure
21. Uncontrolled hypertension at Screening (values \>160/100 mm Hg)

    General safety:
22. Women currently breastfeeding
23. Previous exposure to lanifibranor
24. Participation in any clinical trial investigational medicinal product/device within 3 months from Screening or 5 half-lives from Screening, whichever is longer
25. Concomitant treatment with PPAR-alpha agonists (fibrates)

Primary outcomes:
measure: Resolution of NASH and improvement of fibrosis
timeFrame: Part A: Date of randomisation until the date of biopsy at Week 72
measure: Safety Analyses
timeFrame: 48 weeks after completion of DBPC period
Secondary outcomes:
Other outcomes:
Locations:
city: Anniston
country: United States
facility: Pinnacle Research Group
state: Alabama
city: Birmingham
country: United States
facility: Objective Health - Birmingham Gastroenterology Associates
state: Alabama
city: Dothan
country: United States
facility: Digestive Health Specialist of the Southeast
state: Alabama
city: Madison
country: United States
facility: North Alabama GI Research Center llc
state: Alabama
city: Chandler
country: United States
facility: The Institute For Liver Health - Chandler
state: Arizona
city: Peoria
country: United States
facility: Arizona Liver Health - Peoria
state: Arizona
city: Phoenix
country: United States
facility: Saint Joseph's Hospital and Medical Center
state: Arizona
city: Tucson
country: United States
facility: Arizona Digestive Health - Sun City
state: Arizona
city: Tucson
country: United States
facility: Adobe Gastroenterology
state: Arizona
city: Tucson
country: United States
facility: Arizona Liver Health
state: Arizona
city: Tucson
country: United States
facility: Del Sol Research Management - Tucson East
state: Arizona
city: Conway
country: United States
facility: ARcare Center for Clinical Research - Conway
state: Arkansas
city: Little Rock
country: United States
facility: ARcare Center for Clinical Research
state: Arkansas
city: Little Rock
country: United States
facility: Arkansas Diagnostic Center
state: Arkansas
city: North Little Rock
country: United States
facility: Arkansas Gastroenterology
state: Arkansas
city: Bakersfield
country: United States
facility: Office of Franco Felizarta, MD
state: California
city: Camarillo
country: United States
facility: Fomatmedicalresearch
state: California
city: Chula Vista
country: United States
facility: Precision Research Institute
state: California
city: Chula Vista
country: United States
facility: GW Research
state: California
city: Chula Vista
country: United States
facility: Velocity Clinical Research, Chula Vista
state: California
city: El Cajon
country: United States
facility: TriWest Research Associates
state: California
city: Fountain Valley
country: United States
facility: Cure Clinical Research, LLC
state: California
city: Garden Grove
country: United States
facility: SC Clinical Research
state: California
city: Huntington Park
country: United States
facility: National Research Institute - Santa Ana
state: California
city: Lancaster
country: United States
facility: The Clinical Trials Network - Gastro Care Institute
state: California
city: Los Angeles
country: United States
facility: National Research Institute - Westlake
state: California
city: Panorama City
country: United States
facility: National Research Institute - Panorama City
state: California
city: Pasadena
country: United States
facility: California Liver Reearch
state: California
city: Poway
country: United States
facility: Cadena Care Institute
state: California
city: Rancho Cucamonga
country: United States
facility: Prospective Research Innovations Inc.
state: California
city: Redwood City
country: United States
facility: Stanford University Medical Center
state: California
city: Rialto
country: United States
facility: Inland Empire Liver Foundation
state: California
city: San Diego
country: United States
facility: Research and Education, Inc.
state: California
city: San Francisco
country: United States
facility: California Pacific Medical Center Research Institute
state: California
city: San Francisco
country: United States
facility: Quest Clinical Research
state: California
city: San Jose
country: United States
facility: Silicon Valley Research Institute
state: California
city: Thousand Oaks
country: United States
facility: Clinical Trial Management Services
state: California
city: Van Nuys
country: United States
facility: San Fernando Valley Health Institute
state: California
city: Englewood
country: United States
facility: South Denver Gastroenterology - Swedish Medical Center Office
state: Colorado
city: Bridgeport
country: United States
facility: Bridgeport Hospital
state: Connecticut
city: New Haven
country: United States
facility: Yale School of Medicine
state: Connecticut
city: Adventura
country: United States
facility: MedBio Trials
state: Florida
city: Boca Raton
country: United States
facility: Excel Medical Clinical Trials, LLC
state: Florida
city: Bradenton
country: United States
facility: Synergy Healthcare
state: Florida
city: Clearwater
country: United States
facility: Tampa Bay Medical Research
state: Florida
city: Clearwater
country: United States
facility: Gastro Florida
state: Florida
city: Coral Gables
country: United States
facility: Hi Tech and Global Research, LLC
state: Florida
city: Cutler Bay
country: United States
facility: American Research Institute, INC
state: Florida
city: Cutler Bay
country: United States
facility: JY Research Institute Inc.
state: Florida
city: Cutler Bay
country: United States
facility: Top Medical Research
state: Florida
city: Hialeah
country: United States
facility: Doral Medical Research, LLC
state: Florida
city: Hialeah
country: United States
facility: Palmetto Research
state: Florida
city: Lakewood Ranch
country: United States
facility: Florida Research Institute
state: Florida
city: Lehigh Acres
country: United States
facility: Galenus Group
state: Florida
city: Maitland
country: United States
facility: Accel Research Sites
state: Florida
city: Maitland
country: United States
facility: Centor for Advanced Gastroenterology - Main Office - Maitland
state: Florida
city: Miami
country: United States
facility: Florida Vascular Research
state: Florida
city: Miami
country: United States
facility: Life Medical Research Group
state: Florida
city: Miami
country: United States
facility: Optimus U Corporation
state: Florida
city: Miami
country: United States
facility: Schiff Center for Liver Diseases
state: Florida
city: Miami
country: United States
facility: D&H National Research Centers
state: Florida
city: Miami
country: United States
facility: USPA Advance Concept Medical Research Group
state: Florida
city: Miami
country: United States
facility: Future Care Solution
state: Florida
city: Miami
country: United States
facility: Genoma Research Group
state: Florida
city: Miami
country: United States
facility: Gastro Health - Galloway
state: Florida
city: Miami
country: United States
facility: Pro Live Medical Research
state: Florida
city: Miami
country: United States
facility: Miami Dade Medical Research Institute
state: Florida
city: Miami
country: United States
facility: Clinical Trials Services Corporation
state: Florida
city: New Port Richey
country: United States
facility: Advanced Research Institute
state: Florida
city: Ocoee
country: United States
facility: Sensible Healthcare Clinical Research
state: Florida
city: Orlando
country: United States
facility: AdventHealth Transplant Institute
state: Florida
city: Orlando
country: United States
facility: Digestive and Liver Center of Florida - Orlando
state: Florida
city: Palmetto Bay
country: United States
facility: IMIC Research - International Medical Investigations Centers
state: Florida
city: Pembroke Pines
country: United States
facility: American Research Centers of Florida
state: Florida
city: Pensacola
country: United States
facility: Pensacola GI Research Center
state: Florida
city: Plantation
country: United States
facility: Eminat, LLC
state: Florida
city: Pompano Beach
country: United States
facility: NAPA Research
state: Florida
city: Sarasota
country: United States
facility: Covenant Metabolic Specialists LLC - Sarasota
state: Florida
city: Tampa
country: United States
facility: Tampa General Hospital
state: Florida
city: Wellington
country: United States
facility: GI Alliance - Gastroenterology Associates of Florida - Wellington
state: Florida
city: Weston
country: United States
facility: Cleveland Clinic Florida
state: Florida
city: Zephyrhills
country: United States
facility: Florida Medical Clinic - Zephyrhills
state: Florida
city: Athens
country: United States
facility: Athens Gastroenterology Association
state: Georgia
city: Atlanta
country: United States
facility: Digestive Healthcare of Georgia
state: Georgia
city: Atlanta
country: United States
facility: Research and Education Foundation of Atlanta Medical Center
state: Georgia
city: College Park
country: United States
facility: Oracle Clinical Research
state: Georgia
city: Columbus
country: United States
facility: IACT Health
state: Georgia
city: Dalton
country: United States
facility: Southeast Clinical Research Center
state: Georgia
city: LaGrange
country: United States
facility: Regional Infectious Diseases and Infusion Center
state: Georgia
city: Idaho Falls
country: United States
facility: Grand Teton Research Group, PLLC
state: Idaho
city: Chicago
country: United States
facility: Northwestern University
state: Illinois
city: Chicago
country: United States
facility: University of Chicago
state: Illinois
city: Skokie
country: United States
facility: NorthShore University HealthSystem
state: Illinois
city: Hammond
country: United States
facility: ASHA Clinical Research - Munster
state: Indiana
city: Clive
country: United States
facility: Heartland Medical Research
state: Iowa
city: Iowa City
country: United States
facility: University of Iowa Hospitals and Clinics
state: Iowa
city: Kansas City
country: United States
facility: Arizona Digestive Health - Sun City
state: Kansas
city: Kansas City
country: United States
facility: University of Kansas Medical Center Research Institute
state: Kansas
city: Topeka
country: United States
facility: Kansas Medical Clinic - Gastroenterology
state: Kansas
city: Lexington
country: United States
facility: University of Kentucky
state: Kentucky
city: Baton Rouge
country: United States
facility: Gastroenterology Associates - Baton Rouge
state: Louisiana
city: Houma
country: United States
facility: Tandem Clinical Research GI
state: Louisiana
city: Lafayette
country: United States
facility: Combined Gastro Research LLC
state: Louisiana
city: Marrero
country: United States
facility: Tandem Clinical Research
state: Louisiana
city: Metairie
country: United States
facility: Metropolitan Gastroenterology Associates - Metairie
state: Louisiana
city: Metairie
country: United States
facility: Tandem Clinical Research GI, LLC
state: Louisiana
city: Shreveport
country: United States
facility: Louisiana Research Center LLC
state: Louisiana
city: Annapolis
country: United States
facility: Investigative Clinical Research - Annapolis
state: Maryland
city: Baltimore
country: United States
facility: Mercy Medical Center - Mcauley Plaza
state: Maryland
city: Baltimore
country: United States
facility: The Johns Hopkins Hospital
state: Maryland
city: Catonsville
country: United States
facility: Digestive Disease Associates - Catonsville
state: Maryland
city: Chevy Chase
country: United States
facility: Chevy Chase Clinical Research
state: Maryland
city: Columbia
country: United States
facility: Gastro Center of Maryland - Columbia
state: Maryland
city: Greenbelt
country: United States
facility: Mid-Atlantic GI Research
state: Maryland
city: Hagerstown
country: United States
facility: Meritus Center for Clinical Research
state: Maryland
city: Boston
country: United States
facility: Massachusetts General Hospital
state: Massachusetts
city: Boston
country: United States
facility: Boston Medical Center
state: Massachusetts
city: Boston
country: United States
facility: Beth Israel Deaconess Medical Center - Liver Center
state: Massachusetts
city: Fall River
country: United States
facility: NECCR Prima Care Research, LLC
state: Massachusetts
city: Chesterfield
country: United States
facility: Clinical Research Institute of Michigan
state: Michigan
city: Detroit
country: United States
facility: Henry Ford Health System
state: Michigan
city: Wyoming
country: United States
facility: Gastroenterology Associates of Western Michigan
state: Michigan
city: Wyoming
country: United States
facility: University of Michigan Health-West Hospital
state: Michigan
city: Minneapolis
country: United States
facility: MNGI Digestive Health - Northeast Minneapolis Clinic
state: Minnesota
city: Rochester
country: United States
facility: Mayo Clinic - Rochester
state: Minnesota
city: Flowood
country: United States
facility: Gastrointestinal Associates & Endoscopy Center - Flowood
state: Mississippi
city: Ridgeland
country: United States
facility: SKYCRNG - Quinn Healthcare
state: Mississippi
city: Chesterfield
country: United States
facility: Galen Research
state: Missouri
city: Columbia
country: United States
facility: Gastrointestinal (GI) Associates L.L.P.
state: Missouri
city: Kansas City
country: United States
facility: Saint Luke's Hospital of Kansas City
state: Missouri
city: Kansas City
country: United States
facility: Kansas City Research Institute
state: Missouri
city: Saint Louis
country: United States
facility: SSM Health Saint Louis University Hospital
state: Missouri
city: Saint Louis
country: United States
facility: Washington University School of Medicine in St. Louis
state: Missouri
city: Las Vegas
country: United States
facility: Sierra Clinical Research - Las Vegas
state: Nevada
city: Albuquerque
country: United States
facility: Southwest Gastroenterology Associates
state: New Mexico
city: Buffalo
country: United States
facility: State University of New York - University at Buffalo
state: New York
city: New York
country: United States
facility: Weill Cornell Medical College
state: New York
city: New York
country: United States
facility: Icahn School of Medicine at Mount Sinai
state: New York
city: New York
country: United States
facility: Tandem Clinical Research - New York Clinic
state: New York
city: Rochester
country: United States
facility: University of Rochester Medical Center
state: New York
city: Staten Island
country: United States
facility: Richmond University Medical Center
state: New York
city: Charlotte
country: United States
facility: Charlotte Gastroenterology and Hepatology - Randolph Road Office
state: North Carolina
city: Concord
country: United States
facility: ObjectiveGI - Northeast GI Research
state: North Carolina
city: Durham
country: United States
facility: Duke University Medical Center
state: North Carolina
city: Fayetteville
country: United States
facility: Cumberland Research Associates
state: North Carolina
city: Greenville
country: United States
facility: Carolina Digestive Diseases
state: North Carolina
city: Morehead City
country: United States
facility: Lucas Research, Inc
state: North Carolina
city: Winston-Salem
country: United States
facility: Gastroenterology of the Piedmont, PA - Salem Office
state: North Carolina
city: Cincinnati
country: United States
facility: Consultants for Clinical Research - Montgomery Office
state: Ohio
city: Cleveland
country: United States
facility: University Hospitals Case Medical Center
state: Ohio
city: Columbus
country: United States
facility: The Ohio State University
state: Ohio
city: Columbus
country: United States
facility: Aventiv Research - Columbus
state: Ohio
city: Dayton
country: United States
facility: Digestive Specialists - Dayton
state: Ohio
city: Dublin
country: United States
facility: Ohio Gastroenterology Group, Inc. - Olentangy Office
state: Ohio
city: Mentor
country: United States
facility: Great Lakes Gastroenterology Research - Mentor
state: Ohio
city: Westlake
country: United States
facility: North Shore Gastroenterology
state: Ohio
city: Oklahoma City
country: United States
facility: INTEGRIS Baptist Medical Center
state: Oklahoma
city: Tulsa
country: United States
facility: Options Health Research
state: Oklahoma
city: Pittsburgh
country: United States
facility: Veterans Affairs Pittsburgh Healthcare System - University Drive Campus
state: Pennsylvania
city: Pittsburgh
country: United States
facility: University of Pittsburgh Medical Center
state: Pennsylvania
city: Charleston
country: United States
facility: Medical University of South Carolina
state: South Carolina
city: Summerville
country: United States
facility: Palmetto Clinical Research
state: South Carolina
city: West Columbia
country: United States
facility: Clinovacare Medical Clinical Research Center
state: South Carolina
city: Rapid City
country: United States
facility: Rapid City Medical Center
state: South Dakota
city: Germantown
country: United States
facility: Gastro One - Germantown Office - Wolf Park Drive
state: Tennessee
city: Nashville
country: United States
facility: Vanderbilt University Medical Center
state: Tennessee
city: Arlington
country: United States
facility: Texas Clinical Research Institute
state: Texas
city: Austin
country: United States
facility: Accelemed Research Institute
state: Texas
city: Austin
country: United States
facility: Pinnacle Clinical Research - Austin
state: Texas
city: Beaumont
country: United States
facility: Gadolin Research
state: Texas
city: Brownsville
country: United States
facility: South Texas Research Institute - Brownsville
state: Texas
city: Brownsville
country: United States
facility: PanAmerican Clinical Research - US Headquarters
state: Texas
city: Cedar Park
country: United States
facility: Velocity Clinical Research - Austin
state: Texas
city: Dallas
country: United States
facility: The Liver Institute at Methodist Dallas
state: Texas
city: Dallas
country: United States
facility: Liver Center of Texas
state: Texas
city: Dallas
country: United States
facility: GI Alliance - Texas Digestive Disease Consultants - Fort Worth - Downtown
state: Texas
city: Denison
country: United States
facility: Soma Clinical Trials
state: Texas
city: Edinburg
country: United States
facility: South Texas Research Institute - Edinburg
state: Texas
city: El Paso
country: United States
facility: Gastro Clinic
state: Texas
city: Forney
country: United States
facility: Care United Medical Center - Forney
state: Texas
city: Fort Sam Houston
country: United States
facility: Brooke Army Medical Center
state: Texas
city: Friendswood
country: United States
facility: Allure Health, Llc
state: Texas
city: Garland
country: United States
facility: Digestive Health Associates of Texas - Rockwall
state: Texas
city: Georgetown
country: United States
facility: Summitt - Pinnacle Clinical Research - Georgetown
state: Texas
city: Georgetown
country: United States
facility: Advanced Medical Trials
state: Texas
city: Houston
country: United States
facility: Houston Methodist Hospital
state: Texas
city: Houston
country: United States
facility: Liver Associates of Texas
state: Texas
city: Houston
country: United States
facility: Liver Specialists of Texas
state: Texas
city: Houston
country: United States
facility: Liver Specialists of Texas
state: Texas
city: Houston
country: United States
facility: Gastroenterology Consultants - Ellington
state: Texas
city: Houston
country: United States
facility: Alpha Research Institute, LLC
state: Texas
city: Houston
country: United States
facility: Houston Research Institute (HRI)
state: Texas
city: Houston
country: United States
facility: Headlands - Centex Studies - Westfield
state: Texas
city: Houston
country: United States
facility: Pioneer Research Solutions
state: Texas
city: Lubbock
country: United States
facility: GI Alliance - Lubbock Digestive Disease Associates - Lubbock
state: Texas
city: Mansfield
country: United States
facility: GI Alliance - Mansfield
state: Texas
city: McAllen
country: United States
facility: Koncord Research - McAllen LLC
state: Texas
city: McAllen
country: United States
facility: Koncord Research-McAllen LLC
state: Texas
city: San Antonio
country: United States
facility: Quality Research - San Antonio
state: Texas
city: San Antonio
country: United States
facility: Sun Research Institute
state: Texas
city: San Antonio
country: United States
facility: Texas Liver Institute/American Research Corporation
state: Texas
city: San Antonio
country: United States
facility: University of California San Diego
state: Texas
city: San Antonio
country: United States
facility: Pinnacle Clinical Research - San Antonio
state: Texas
city: Sherman
country: United States
facility: Sherman Clinical Research
state: Texas
city: Waco
country: United States
facility: Impact Research Institute
state: Texas
city: Waco
country: United States
facility: Digestive Health Research of Central Texas
state: Texas
city: Webster
country: United States
facility: GI Alliance - Bay Area Gastroenterology - Webster
state: Texas
city: Webster
country: United States
facility: Tranquil Clinical Research
state: Texas
city: Wichita Falls
country: United States
facility: Digestive Health Research of North Texas
state: Texas
city: Draper
country: United States
facility: Lone Peak Family Health
state: Utah
city: Salt Lake City
country: United States
facility: University of Utah School of Medicine
state: Utah
city: Burlington
country: United States
facility: University of Vermont Medical Center
state: Vermont
city: Charlottesville
country: United States
facility: University of Virginia Health System
state: Virginia
city: Fairfax
country: United States
facility: Gastroenterology Associates of Northern Virginia
state: Virginia
city: Falls Church
country: United States
facility: Inova Medical Group - Fairfax Hospital
state: Virginia
city: Leesburg
country: United States
facility: Emeritas Research Group
state: Virginia
city: Manassas
country: United States
facility: Topography Health, Inc.
state: Virginia
city: Newport News
country: United States
facility: Bon Secours Liver Institute of Hampton Roads
state: Virginia
city: Norfolk
country: United States
facility: Digestive & Liver Disease Specialists
state: Virginia
city: Richmond
country: United States
facility: GI Select Health Research, LLC
state: Virginia
city: Richmond
country: United States
facility: Hunter Holmes Mcguire Veterans Affairs Medical Center - Richmond
state: Virginia
city: Richmond
country: United States
facility: Virginia Commonwealth University
state: Virginia
city: Seattle
country: United States
facility: Liver Institute Northwest
state: Washington
city: Milwaukee
country: United States
facility: Froedtert and Medical College of Wisconsin
state: Wisconsin
city: Ciudad Autónoma De Buenos Aires
country: Argentina
facility: Hospital Italiano de Buenos Aires
state: Buenos Aires
city: La Plata
country: Argentina
facility: Hospital Italiano La Plata
state: Buenos Aires
city: Pilar
country: Argentina
facility: Hospital Universitario Austral
state: Buenos Aires
city: Buenos Aires
country: Argentina
facility: Hospital De Alta Complejidad en Red El Cruce
state: Buenos Aries
city: Rosario
country: Argentina
facility: Hospital Provincial del Centenario
state: Santa Fe
city: Buenos Aires
country: Argentina
facility: Hospital Británico de Buenos Aires
city: Concord
country: Australia
facility: Concord Repatriation General Hospital
state: New South Wales
city: Liverpool
country: Australia
facility: Campbelltown Hospital
state: New South Wales
city: Liverpool
country: Australia
facility: Liverpool Hospital
state: New South Wales
city: New Lambton
country: Australia
facility: John Hunter Hospital
state: New South Wales
city: Penrith
country: Australia
facility: Nepean Hospital
state: New South Wales
city: Greenslopes
country: Australia
facility: Gallipoli Medical Research Foundation
state: Queensland
city: Herston
country: Australia
facility: Royal Brisbane and Women's Hospital
state: Queensland
city: Box Hill
country: Australia
facility: Eastern Health - Australia
state: Victoria
city: Clayton
country: Australia
facility: Monash Medical Centre
state: Victoria
city: Heidelberg
country: Australia
facility: Austin Health
state: Victoria
city: Murdoch
country: Australia
facility: Fiona Stanley Hospital
state: Western Australia
city: Perth
country: Australia
facility: Royal Perth Hospital
state: Western Australia
city: Innsbruck
country: Austria
facility: Medizinische Universität Innsbruck
state: Tyrol
city: Edegem
country: Belgium
facility: Universitair Ziekenhuis Antwerpen
state: Antwerpen
city: Bruxelles
country: Belgium
facility: Hôpital Erasme
state: Bruxelles Capitale
city: Leuven
country: Belgium
facility: Universitair Ziekenhuis Leuven - Campus Gasthuisberg
state: Flemish Brabant
city: Genk
country: Belgium
facility: Ziekenhuis Oost-Limburg - Campus Sint-Jan
state: Limburg
city: Gent
country: Belgium
facility: Algemeen Ziekenhuis Maria Middelares
state: Oost-Vlaaderen
city: Gent
country: Belgium
facility: Universitair Ziekenhuis Gent
state: Oost-Vlaanderen
city: Sint-Niklaas
country: Belgium
facility: Vitaz
state: Oost-Vlaanderen
city: Brugge
country: Belgium
facility: Algemeen Ziekenhuis Sint-Jan Brugge-Oostende - Campus Sint-Jan
state: West-Vlaanderen
city: Roeselare
country: Belgium
facility: Algemeen Ziekenhuis Delta - Campus Rumbeke
state: West-Vlaanderen
city: Brussel
country: Belgium
facility: Cliniques Universitaires Saint-Luc
city: Liège
country: Belgium
facility: Centre Hospitalier Universitaire de Liège Site Sart Tilman
city: Belo Horizonte
country: Brazil
facility: Hospital das Clinicas da Universidade Federal de Minas Gerais
state: Minas Gerais
city: Porto Alegre
country: Brazil
facility: Hospital Ernesto Dornelles
state: Rio De Janeiro
city: Porto Alegre
country: Brazil
facility: Hospital de Clínicas de Porto Alegre
state: Rio Grande Do Sul
city: Cerqueira César
country: Brazil
facility: Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo
state: Sao Paulo
city: Ribeirão Preto
country: Brazil
facility: Hospital das Clínicas da Faculdade de Medicina de Ribeirão Preto
state: São Paulo
city: São José Do Rio Preto
country: Brazil
facility: Fundação Faculdade Regional de Medicina de São José do Rio Preto
state: São Paulo
city: Sofia
country: Bulgaria
facility: University Multiprofile Hospital for Active Treatment St. Ivan Rilski
state: Sofia City
city: Sofia
country: Bulgaria
facility: University Multiprofile Hospital for Active Treatment and Emergency Medicine N.I. Pirogov
state: Sofia City
city: Sofia
country: Bulgaria
facility: Acibadem City Clinic Tokuda Hospital
city: Sofia
country: Bulgaria
facility: Diagnostic Consultative Center Aleksandrovska
city: Sofia
country: Bulgaria
facility: Diagnostic Consulting Center 20 - Sofia Еооd
city: Stara Zagora
country: Bulgaria
facility: Nov Rehabilitatsionen Tsentar EOOD
city: Veliko Tarnovo
country: Bulgaria
facility: Medical Center Medica Plus
city: Calgary
country: Canada
facility: Heritage Medical Research Centre
state: Alberta
city: Brampton
country: Canada
facility: William Osler Health System - Brampton Civic Hospital
state: Ontario
city: Hamilton
country: Canada
facility: St. Joseph's Healthcare Hamilton - Charlton Campus
state: Ontario
city: Toronto
country: Canada
facility: University Health Network
state: Ontario
city: Vaughan
country: Canada
facility: Toronto Digestive Disease Associates
state: Ontario
city: Montréal
country: Canada
facility: McGill University Health Centre
state: Quebec
city: Terrebonne
country: Canada
facility: Centre de Médecine Métabolique de Lanaudière
state: Quebec
city: La Serena
country: Chile
facility: Hospital San Juan de Dios de La Serena
state: Coquimbo
city: Viña Del Mar
country: Chile
facility: Centro De Investigaciones Clínicas Viña Del Mar
state: Valparaíso
city: Santiago
country: Chile
facility: Pontificia Universidad Católica de Chile - Escuela de Medicina
city: Beijing
country: China
facility: Beijing Ditan Hospital, Capital Medical University
state: Beijing
city: Beijing
country: China
facility: Peking University First Hospital
state: Beijing
city: Beijing
country: China
facility: Peking University People's Hospital
state: Beijing
city: Chongqing
country: China
facility: Chongqing university three gorges hospital
state: Chongging
city: Chongqing
country: China
facility: First Affiliated Hospital of the Army Military Medical University (Southwest Hospital)
state: Chongging
city: Chongqing
country: China
facility: The First Affiliated Hospital of Chongqing Medical University
state: Chongqing
city: Beijing
country: China
facility: Beijing You'an Hospital,Capital Medical University
state: Fengtai
city: Fuzhou
country: China
facility: The First Affiliated Hospital of Fujian Medical University
state: Fujian
city: Lanzhou
country: China
facility: The First Hospital of Lanzhou University
state: Gansu
city: Guangzhou
country: China
facility: Guangzhou First People's Hospital
state: Guangdong
city: Guangzhou
country: China
facility: Nanfang Hospital of Southern Medical University
state: Guangdong
city: Guangzhou
country: China
facility: The Eighth Affiliated Hospital,GuangZhou Medical University
state: Guangdong
city: Guangzhou
country: China
facility: The First Affiliated Hospital Sun Yat-sen University
state: Guangdong
city: Nanning
country: China
facility: The First Affiliated Hospital of Guangxi Medical University
state: Guangxi
city: Guiyang
country: China
facility: Guizhou Provincial People's Hospital
state: Guizhou
city: Guiyang
country: China
facility: The Affiliated Hospital of Guizhou Medical University
state: Guizhou
city: Harbin
country: China
facility: Fourth Affiliated Hospital of Harbin Medical University
state: Heilongjiang
city: Luoyang
country: China
facility: The First Affiliated Hospital of Henan University of Science and Technology
state: Henan
city: Nanyang
country: China
facility: The First Affiliated Hospital of Nanyang Medical College
state: Henan
city: Sanmenxia
country: China
facility: Sanmenxia Central Hospital
state: Henan
city: Zhengzhou
country: China
facility: Henan Provincal People's Hospital
state: Henan
city: Zhengzhou
country: China
facility: The Sixth People's Hospital of Zhengzhou
state: Henan
city: Zhengzhou
country: China
facility: Zhengzhou First People's Hospital
state: Henan
city: Wuhan
country: China
facility: Union Hospital Tongji Medical College Huazhong University of Science and Technology
state: Hubei
city: Nanjing
country: China
facility: Jiangsu Provincial People's Hospital
state: Jiangsu
city: Nanjing
country: China
facility: The Second Hospital of Nanjing
state: Jiangsu
city: Nantong
country: China
facility: Affiliated Hospital of Nantong University
state: Jiangsu
city: Suzhou
country: China
facility: The Fifth People's Hospital of Suzhou
state: Jiangsu
city: Wuxi
country: China
facility: Wuxi No.5 People's Hospital
state: Jiangsu
city: Zhenjiang
country: China
facility: Third People's Hospital of Zhenjiang
state: Jiangsu
city: Nanchang
country: China
facility: The Second Affiliated Hospital of Nanchang University
state: Jiangxi
city: Shenyang
country: China
facility: First Affiliated Hospital of China Medical University
state: Liaoning
city: Shenyang
country: China
facility: The Sixth People' s Hospital Of ShenYang
state: Liaoning
city: Xi'an
country: China
facility: Xi'an International Medical Center
state: Shaanxi
city: Qingdao
country: China
facility: Qingdao Central Hospital
state: Shandong
city: Taiyuan
country: China
facility: Xu, Jun The First Hospital of Shanxi Medical University Taiyun Shanxi
state: Shanxi
city: Xi'an
country: China
facility: The First Affiliated Hospital of Xi'an Jiaotong University
state: Shanxi
city: Chengdu
country: China
facility: Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital
state: Sichuan Shi
city: Tianjin
country: China
facility: The Second Hospital of Tianjin Medical University
state: Tianjin
city: Kunming
country: China
facility: The First People's Hospital of Yunnan Province
state: Yunnan
city: Hangzhou
country: China
facility: The First Affiliated Hospital , Zhejiang University School of Medicine
state: Zhejiang
city: Ruian
country: China
facility: RuiAn People's Hospital - Ruixiang Branch
state: Zhejiang
city: Wenzhou
country: China
facility: The First Affiliated Hospital of Wenzhou Medical University
state: Zhejiang
city: Changchun
country: China
facility: The First Hospital of Jilin University
city: Changsha
country: China
facility: Xiangya Hospital - Central South University
city: Chengdu
country: China
facility: West china hospital Sichuan University
city: Chongqing
country: China
facility: The Second Affiliated Hospital of Chongqing Medical University
city: Dalian
country: China
facility: Second Affiliated Hospital of Dalian Medical University
city: Fuzhou
country: China
facility: Mengchao Hepatobiliary Hospital of FuJian Medical University
city: Guangzhou
country: China
facility: Guangdong Provincial people's hospital
city: Guangzhou
country: China
facility: The Third Affiliated Hospital, Sun Yat-Sen University
city: Hangzhou
country: China
facility: Sir Run Run Shaw Hospital of Zhejiang University School of Medicine - Qingchun Campus
city: Heping
country: China
facility: General Hospital of Tianjin Medical University
city: Ningbo
country: China
facility: Ningbo No.2 Hospital (Hwa Mei Hospital)
city: Qingdao
country: China
facility: Qingdao Municipal Hospital
city: Shanghai
country: China
facility: Ruijin Hospital, Shanghai Jiaotong University School of Medicine
city: Shenyang
country: China
facility: Shengjing Hospital of China Medical University
city: Shenzhen
country: China
facility: The University of Hong Kong-Shenzhen Hospital
city: Tianjin
country: China
facility: Tianjin Third Central Hospital
city: Zhengzhou
country: China
facility: The First Affiliated Hospital of Zhengzhou University
city: Zhengzhou
country: China
facility: Zhengzhou People's Hospital
city: Plzen
country: Czechia
facility: Research Site s.r.o.
city: Praha
country: Czechia
facility: Synexus Czech - DRS Prague
city: Strasbourg
country: France
facility: Hôpital Hautepierre
state: Bas-Rhin
city: Marseille
country: France
facility: Hôpital Saint-Joseph
state: Bouches-du-Rhône
city: Dijon
country: France
facility: CHU Dijon Bourgogne - Hôpital François Mitterrand
state: Cantal
city: Besançon
country: France
facility: CHRU de Besançon - Hôpital Jean-Minjoz
state: Franche-Comté
city: Lille
country: France
facility: CHU de Lille - Hôpital Claude Huriez
state: Hauts-de-France
city: Clichy
country: France
facility: Hôpitaux Universitaires Paris Nord Val-de-Seine - Hôpital Beaujon
state: Ile-de-France
city: Créteil
country: France
facility: Hôpitaux Universitaires Henri Mondor
state: Ile-de-France
city: Paris
country: France
facility: Hôpital Universitaire Pitié Salpêtrière
state: Ile-de-France
city: Paris
country: France
facility: Hôpital Saint-Antoine
state: Ile-de-France
city: Villejuif
country: France
facility: Hôpitaux Universitaires Paris-Sud - Hôpital Paul Brousse
state: Ile-de-France
city: Rennes
country: France
facility: Centre Hospitalier Universitaire de Rennes
state: Ille-et-Vilaine
city: Grenoble
country: France
facility: Centre Hospitalier Universitaire Grenoble Alpes
state: Isère
city: Limoges
country: France
facility: CHU de Limoges
state: Limousin
city: Nantes
country: France
facility: Centre Hospitalier Universitaire De Nantes - Hôpital Nord Laennec
state: Loire Atlantique
city: Vandœuvre-lès-Nancy
country: France
facility: Hôpitaux de Brabois
state: Lorraine
city: Vandœuvre-lès-Nancy
country: France
facility: Hôpitaux de Brabois
state: Lorraine
city: Angers Cedex 9
country: France
facility: Centre Hosptitalier Universitaire d'Angers
state: Maine-et-Loire
city: Angers
country: France
facility: Centre Hosptitalier Universitaire d'Angers
state: Maine-et-Loire
city: Nantes
country: France
facility: Centre Hospitalier Universitaire De Nantes - Hôpital Nord Laennec
state: Nantes Cedex 1
city: Pessac
country: France
facility: Hôpital Haut-Lévêque
state: Nouvelle-Aquitaine
city: Pessac
country: France
facility: Hôpital Haut-Lévêque
state: Nouvelle-Aquitaine
city: Montpellier
country: France
facility: CHU Saint-Eloi
state: Occitanie
city: Toulouse
country: France
facility: Hôpital Rangueil
state: Occitanie
city: Toulouse
country: France
facility: Clinique Pasteur
state: Occitanie
city: Nice
country: France
facility: Hôpital l'Archet
state: Provence-Alpes-Côte d'Azur
city: Clermont-Ferrand
country: France
facility: Centre Hospitalier Universitaire Estaing
state: Puy-de-Dôme
city: Lyon
country: France
facility: Hôpital de la Croix Rousse
state: Rhône-Alpes
city: Paris
country: France
facility: Hôpital Cochin
city: Karlsruhe
country: Germany
facility: Klinische Forschung Karlsruhe GmbH
state: Baden-Württemberg
city: Wiesbaden
country: Germany
facility: St. Josefs-Hospital Wiesbaden
state: Hessen
city: Herne
country: Germany
facility: Gastroenterologische Gemeinschaftspraxis Herne
state: Nordrhein-Westfalen
city: Mainz
country: Germany
facility: Universitätsmedizin der Johannes Gutenberg-Universität Mainz
state: Rheinland-Pfalz
city: Homburg
country: Germany
facility: Universitätsklinikum des Saarlandes
state: Saarland
city: Chemnitz
country: Germany
facility: Klinikum Chemnitz
state: Sachsen
city: Dresden
country: Germany
facility: Universitätsklinikum Carl Gustav Carus Dresden
state: Sachsen
city: Leipzig
country: Germany
facility: Eugastro
state: Sachsen
city: Lübeck
country: Germany
facility: Universitätsklinikum Schleswig-Holstein - Campus Lübeck
state: Schleswig-Holstein
city: Berlin
country: Germany
facility: EPIMED
city: Berlin
country: Germany
facility: Gastroenterologie am Bayerischen Platz
city: Berlin
country: Germany
facility: Charité Universitätsmedizin Berlin
city: Köln
country: Germany
facility: Uniklinik Köln
city: Northeim
country: Germany
facility: Universitätsklinikum Düsseldorf
city: Budapest
country: Hungary
facility: SYNEXUS Magyarország Egészségügyi Szolgáltató KFT
state: Central Hungary
city: Debrecen
country: Hungary
facility: Synexus Magyarország Egészségügyi Szolgáltató Kft. - Debrecen
state: Hajdu-Bihar County
city: Debrecen
country: Hungary
facility: Debreceni Egyetem Klinikai Központ Kenézy Gyula Campus
state: Hajdú-Bihar
city: Budapest
country: Hungary
facility: MIND Klinika
city: Budapest
country: Hungary
facility: High Tech Medical Kft.
city: Budapest
country: Hungary
facility: Dél-pesti Centrumkórház - Országos Hematológiai és Infektológiai Intézet
city: Tel Aviv
country: Israel
facility: Tel Aviv Sourasky Medical Center
state: Gush Dan
city: Haifa
country: Israel
facility: Carmel Medical Center
state: Haifa District
city: Jerusalem
country: Israel
facility: Shaare Zedek Medical Center
state: Jerusalem District
city: Jerusalem
country: Israel
facility: Hadassah University Hospital Ein Kerem
state: Jerusalem District
city: Nahariya
country: Israel
facility: Western Galilee Hospital-Nahariya
state: Northern District
city: Be'er Sheva
country: Israel
facility: Soroka Medical Center
state: Southern District
city: Ramat Gan
country: Israel
facility: The Chaim Sheba Medical Center
state: Tel Aviv
city: Haifa
country: Israel
facility: Rambam Health Care Campus
city: San Giovanni Rotondo
country: Italy
facility: Ospedale Casa Sollievo della Sofferenza
state: Foggia
city: Milano
country: Italy
facility: Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico
state: Milan
city: Bologna
country: Italy
facility: Azienda Ospedaliero-Universitaria di Bologna Policlinico Sant Orsola-Malpighi
city: Milan
country: Italy
facility: Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico
city: Napoli
country: Italy
facility: Università degli Studi di Napoli Federico II
city: Novara
country: Italy
facility: Azienda Ospedaliero-Universitaria Maggiore della Carità di Novara
city: Palermo
country: Italy
facility: Azienda Ospedaliera Universitaria Policlinico Paolo Giaccone
city: Roma
country: Italy
facility: Fondazione Policlinico Universitario Agostino Gemelli IRCCS
city: Roma
country: Italy
facility: UOSD Interdipartimentale Degenza Medica a ciclo breve
city: Torino
country: Italy
facility: Azienda Ospedaliero-Universitaria Citta della Salute e della Scienza di Torino
city: Cuauhtémoc
country: Mexico
facility: Centro de Investigación y Gastroenterología
state: Ciudad De México
city: Guadalajara
country: Mexico
facility: Centro de Investigacion Medico Biologica y Terapia Avanzada
state: Jalisco
city: Cuernavaca
country: Mexico
facility: PanAmerican Clinical Research Mexico - Cuernavaca
state: Morelos
city: Monterrey
country: Mexico
facility: Investigaciones Medicas Cisneros
state: Nuevo León
city: Monterrey
country: Mexico
facility: Hospital Universitario Doctor José Eleuterio Gonzalez
state: Nuevo León
city: Mérida
country: Mexico
facility: Medical Care and Research S.A. de C.V.
state: Yucatan
city: Mérida
country: Mexico
facility: Medical Care and Research S.A. de C.V.
state: Yucatan
city: Ciudad de Mexico
country: Mexico
facility: Centro de Investigacion y Gastroenterologia, S.C.
city: Ciudad de México
country: Mexico
facility: Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán (INCMNSZ)
city: Metepec
country: Mexico
facility: Consultorio de la Dra. Maria Sarai Gonzalez Huezo
city: Metepec
country: Mexico
facility: Instituto de Seguridad Social del Estado de Mexico y Municipios
city: Metepec
country: Mexico
facility: Oaxaca Site Management Organization S.C.
city: Mexico City
country: Mexico
facility: Investigacion Biomedica para el Desarrollo de Farmacos S.A. de C.V.
city: Monterrey
country: Mexico
facility: Hospital Universitario "Dr. Jose Eleuterio Gonzalez" (Servicio de Gastroenterologia)
city: Monterrey
country: Mexico
facility: Hospital Universitario "Dr. José Eleuterio González" (Servicio de Endocrinología)
city: Monterrey
country: Mexico
facility: Hospital Universitario Dr. José Eleuterio González
city: Monterrey
country: Mexico
facility: Hospital Universitario Dr. José Eleuterio González
city: Oaxaca
country: Mexico
facility: Oaxaca Site Management Organization S.C.
city: Querétaro
country: Mexico
facility: PanAmerican Clinical Research S.A. de C.V.
city: Zumpango
country: Mexico
facility: Hospital Regional de Alta Especialidad de Zumpango
city: Nijmegen
country: Netherlands
facility: Radboud Universitair Medisch Centrum
state: Gelderland
city: Amsterdam
country: Netherlands
facility: Amsterdam Universitair Medische Centra - Vrije Universiteit Medisch Centrum
state: Noord-Holland
city: Tilburg
country: Netherlands
facility: Elisabeth-TweeSteden Ziekenhuis
state: North Brabant
city: Uden
country: Netherlands
facility: Ziekenhuis Bernhoven
state: North Brabent
city: Rotterdam
country: Netherlands
facility: Erasmus Medisch Centrum
state: Zuid-Holland
city: Rotterdam
country: Netherlands
facility: Franciscus Gasthuis & Vlietland
city: Utrecht
country: Netherlands
facility: Universitair Medisch Centrum Utrecht
city: Wrocław
country: Poland
facility: Synexus - Wrocław
state: Dolnoslaskie
city: Wrocław
country: Poland
facility: Niepubliczny Zaklad Opieki Zdrowotnej Centrum Badan Klinicznych
state: Dolnoslaskie
city: Warszawa
country: Poland
facility: Synexus - Warszawa
state: Mazowieckie
city: Gdynia
country: Poland
facility: Synexus - Gdynia
state: Pomorskie
city: Mysłowice
country: Poland
facility: ID Clinic
state: Silesian Voivodeship
city: Katowice
country: Poland
facility: Synexus - Katowice
state: Slaskie
city: Katowice
country: Poland
facility: Centrum Medyczne Pratia - Katowice
state: Slaskie
city: Poznań
country: Poland
facility: Synexus - Poznań
state: Wielkopolskie
city: Gdańsk
country: Poland
facility: Synexus Polska Sp. z o.o. Oddzial w Gdansku
city: Łódź
country: Poland
facility: Synexus - Łódź
state: Łódzkie
city: Czestochowa
country: Poland
facility: Synexus - Częstochowa
state: Śląskie
city: Guimarães
country: Portugal
facility: Hospital da Senhora da Oliveira - Guimarães
state: Braga
city: Braga
country: Portugal
facility: Hospital de Braga
city: Lisboa
country: Portugal
facility: Centro Hospitalar Universitário Lisboa Norte - Hospital De Santa Maria
city: Porto
country: Portugal
facility: Centro Hospitalar Universitário De São João
city: Senhora Da Hora
country: Portugal
facility: Hospital Pedro Hispano
city: Viana Do Castelo
country: Portugal
facility: Unidade Local Saúde Alto Minho - Hospital de Santa Luzia
city: Vila Real
country: Portugal
facility: Centro Hospitalar de Trás-Os-Montes e Alto-Douro - Hospital de S. Pedro
city: San Juan
country: Puerto Rico
facility: Fundación de Investigación de Diego Clinical Research
city: Pretoria
country: South Africa
facility: Sefako Makgatho Health Sciences University
state: Gauteng
city: Cape Town
country: South Africa
facility: Synexus - Mediclinic Southern Africa - Constantiaberg
state: Western Cape
city: Somerset West
country: South Africa
facility: Synexus - Helderberg Clinical Research Centre - Somerset West
state: Western Cape
city: Pretoria
country: South Africa
facility: Synexus Clinical Research SA- Watermeyer
city: Palma De Mallorca
country: Spain
facility: Hospital Universitario Son Espases
state: Balearic Islands
city: Sabadell
country: Spain
facility: Consorci Corporació Sanitària Parc Taulí de Sabadell
state: Barcelona
city: Santander
country: Spain
facility: Hospital Universitario Marqués de Valdecilla
state: Cantabria
city: Santiago de Compostela
country: Spain
facility: Hospital Clínico Universitario de Santiago
state: La Coruña
city: Alcorcón
country: Spain
facility: Hospital Universitario Fundación Alcorcón
state: Madrid
city: Majadahonda
country: Spain
facility: Hospital Universitario Puerta de Hierro - Majadahonda
state: Madrid
city: Almería
country: Spain
facility: Complejo Hospitalario Torrecárdenas
city: Badalona
country: Spain
facility: Hospital Germans Trias i Pujol
city: Barcelona
country: Spain
facility: Hospital de la Santa Creu i Sant Pau
city: Barcelona
country: Spain
facility: Hospital Universitari Vall d'Hebrón
city: Barcelona
country: Spain
facility: Hospital Clínic de Barcelona
city: León
country: Spain
facility: Complejo Asistencial Universitario de Leon
city: Madrid
country: Spain
facility: Hospital General Universitario Gregorio Marañón
city: Madrid
country: Spain
facility: Clínica Universidad de Navarra
city: Málaga
country: Spain
facility: Hospital Universitario Virgen de la Victoria
city: Pontevedra
country: Spain
facility: Complejo Hospitalario De Pontevedra
city: Sevilla
country: Spain
facility: Hospital Universitario Virgen del Rocío
city: Sevilla
country: Spain
facility: Hospital Universitario Virgen de Valme
city: Valencia
country: Spain
facility: Hospital Clínico Universitario de Valencia
city: Valencia
country: Spain
facility: Consorci Hospital General Universitari de València
city: Valladolid
country: Spain
facility: Hospital Universitario Rio Hortega
city: Zaragoza
country: Spain
facility: Hospital Clinico Universitario Lozano Blesa
city: Zaragoza
country: Spain
facility: Hospital Universitario Miguel Servet
city: Kyiv
country: Ukraine
facility: Medical Center Edelweiss Medics, LLC
city: Kyiv
country: Ukraine
facility: Medical Center Medbud-Clinic, LLC
city: Kyiv
country: Ukraine
facility: Medical Center Center of Family Medicine Plus, LLC
city: London
country: United Kingdom
facility: Barts Health NHS Trust
state: England
city: London
country: United Kingdom
facility: Panthera Biopartners - North London
state: England
city: London
country: United Kingdom
facility: King's College Hospital NHS Foundation Trust
state: England
city: Manchester
country: United Kingdom
facility: Panthera Biopartners - Manchester
state: England
city: Manchester
country: United Kingdom
facility: Panthera Biopartners - Manchester
state: England
city: Newcastle Upon Tyne
country: United Kingdom
facility: The Newcastle Upon Tyne Hospitals NHS Foundation Trust
state: England
city: Nottingham
country: United Kingdom
facility: Nottingham University Hospitals NHS Trust
state: England
city: Preston
country: United Kingdom
facility: Panthera Biopartners - Preston
state: England
city: Sheffield
country: United Kingdom
facility: Sheffield Teaching Hospitals NHS FT
state: England
city: Surrey Quays
country: United Kingdom
facility: Royal Surrey County Hospital NHS Foundation Trust
state: England
city: Glasgow
country: United Kingdom
facility: Panthera Biopartners - Glasgow
state: North Lanarkshire
city: London
country: United Kingdom
facility: Royal Free London NHS Foundation Trust
Study officials:
affiliation: VCU Health, Gastroenterology Hepatology and Nutrition, 1200 West Broad Street, Richmond VA23298, USA
name: Arun J Sanyal, MD
role: PRINCIPAL_INVESTIGATOR
affiliation: Division of Gastroenterology and Hepatology, Antwerp University Hospital, Wilrijkstraat 10, B-2650 Edegem, Belgium
name: Sven Francque, MD
role: PRINCIPAL_INVESTIGATOR
References: