Clinical trial NCT01379352: Vecuronium Requirements According to the Operation Phase During Liver Transplantation Under Desflurane Anesthesia
Official title: Vecuronium Requirements According to the Operation Phase During Liver Transplantation Under Desflurane Anesthesia
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Liver Transplantation
Keywords: liver transplantation
vecuronium
Lead sponsor: Samsung Medical Center
Sponsor class: OTHER
First posted: 2011-06-23
Enrollment: 35
Sex: ALL
Minimum age (years): 20
Maximum age (years): 69
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Patients undergoing elective living donor liver transplantation

Brief summary: The vecuronium requirements may be reduced for recipients of living donor liver transplantation, as the vecuronium is eliminated principally by the liver. Furthermore, the requirements may be different according to the phase of surgery. The requirements may also be different according to the preoperative hepatic function as measured by MELD score during prehepatic phase, or graft to recipient body weight ratio (GRWR) during neohepatic phase. Therefore, the investigators are trying to investigate the difference of vecuronium requirements according to the phase of surgery or MELD score, GRWR.

Detailed description: The vecuronium requirements may be reduced for recipients of living donor liver transplantation, as the vecuronium is eliminated principally by the liver. Furthermore, the requirements may be different according to the phase of surgery. The requirements may by further reduced during anhepatic phase of liver transplantation. And the requirements may be increased as the graft functions during neohepatic phase.

We also postulated that the requirements may be different according to the preoperative hepatic function during preanhepatic phase, and according to the graft to recipient body weight ratio (GRWR) during neohepatic phase.

Therefore, we are trying to investigate the difference of vecuronium requirements according to the phase of surgery, MELD score, GRWR.

Eligibility criteria: Inclusion Criteria:

* patients undergoing elective living donor liver transplantation

Exclusion Criteria:

* patients who can not undergo train-of-four test due to central or peripheral neuromuscular disease.
* patients with severe cardiopulmonary diseases.
* patients who received transfusion with more than 10 units of packed red blood cells.
* primary non-functioning graft immediately after reperfusion of the graft.
* patients who administered drugs that influences the metabolism of vecuronium (such as anticonvulsant: phenytoin, carbamazepine, primidone, sodium valproate)
* patients undergoing cadaver donor liver transplantation

Primary outcomes:
measure: vecuronium requirements during preanhepatic phase
timeFrame: during prehepatic phase of liver transplantation
measure: vecuronium requirements during anhepatic phase
timeFrame: during anhepatic phase of liver transplantation
measure: vecuronium requirements during neohepatic phase
timeFrame: during neohepatic phase of liver transplantation
Secondary outcomes:
Other outcomes:
Locations:
city: Seoul
country: Korea, Republic of
facility: Samsung Medical Center
Study officials:
affiliation: Samsung Medical Center
name: Gaab Soo Kim, M.D.,Ph.D.
role: STUDY_DIRECTOR
References: