Clinical trial NCT02754089: The Effects of Rhus Coriaria L. on Body Weight
Official title: The Effects of Rhus Coriaria L. (Rhus or Somagh) on Body Weight
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Body Weight
Keywords: Body weight changes
Medicine, Traditional
Herbal medicine
Rhus
Waist Circumference
Waist-Hip Ratio
Body mass index
Lead sponsor: Shiraz University of Medical Sciences
Sponsor class: OTHER
First posted: 2016-04-28
Enrollment: 50
Sex: ALL
Minimum age (years): 18
Maximum age (years): 60
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The aim of this study is to evaluate the effects of Rhus coriaria L. (Rhus) commonly known as "Somagh" on body weight.

Detailed description: Rhus coriaria L.(Rhus) is a well-known spice widely consumed in the world which has also been utilized extensively for medicinal purposes. The antioxidant components of this plant made it a favorable target for laboratory and animal studies in different conditions such as oxidative stress cytotoxicity, diabetes and hyperlipidemia. Rhus (Somagh) is found in temperate and tropical regions worldwide, often growing in areas of marginal agricultural capacity. Rhus is used as an herbal remedy in traditional medicine because of its assumed analgesic, antidiarrheic, antiseptic, anorexic and antihyperglycemic properties. The fruits of Rhus contain flavonols, phenolic acids, hydrolysable tannins, anthocyans and organic acids such as malice, citric and tartaric acids. Some studies have shown that polyphenols could have beneficial effects on cardiovascular disease and cancer and could be regarded as bioactive compounds with a high potential health-promoting capacity. Phenolic compounds inhibit lipid peroxidation, scavenge the superoxide anion and hydroxyl radical, and enhance the activities of detoxifying enzymes.

The aim of this study is to evaluate the effects of Rhus coriaria L. (Rhus) commonly known as Somagh on body weight.

Eligibility criteria: Inclusion Criteria:

* Body mass index (BMI) \>= 25 kg/m2

Exclusion Criteria:

* Diabetes mellitus
* Hypo. or hyperthyroidism
* Any systemic illnesses e.g. liver cirrhosis, acute or chronic renal failure, heart failure
* Use of drugs: Weight lowering agents, glucocorticoids, Oral contraceptive pills.
* Pregnancy
* History of allergic reaction to Somagh

Primary outcomes:
measure: Body Mass Index
timeFrame: 6 weeks
Secondary outcomes:
measure: Waist Circumference (cm)
timeFrame: 6 weeks
measure: Hip Circumference (cm)
timeFrame: 6 weeks
measure: Leptin (ng/ml)
timeFrame: 6 weeks
measure: Insulin (mU/l)
timeFrame: 6 weeks
measure: Fasting Blood Glucose (mg/dl)
timeFrame: 6 weeks
measure: Number of patients with adverse event
timeFrame: 6 weeks
Other outcomes:
Locations:
city: Shiraz
country: Iran, Islamic Republic of
facility: Shahid Motahhari Clinic, Shiraz University of Medical Sciences
state: Fars
Study officials:
affiliation: Research Center for Traditional Medicine and History of Medicine, Shiraz University of Medical Sciences, Shiraz, IR Iran
name: Mojtaba Heydari, MD
role: PRINCIPAL_INVESTIGATOR
affiliation: Endocrine and Metabolism Research Center, Shiraz University of Medical Sciences
name: Gholamhossein Ranjbar Omrani, MD
role: STUDY_CHAIR
affiliation: Department of Internal Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
name: Zahra Hajmohammadi, MD
role: PRINCIPAL_INVESTIGATOR
References: