Clinical trial NCT03348085: Is Optimal Minute Ventilation a Predictor of Weaning in Patients With Prolong Mechanical Ventilation?
Official title: Taipei Tzu Chi Hospital , Buddhist Tzu Chi Medical Foundation
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Chronic Respiratory Failure
Lead sponsor: Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation
Sponsor class: OTHER
First posted: 2017-11-20
Enrollment: 120
Sex: ALL
Minimum age (years): 20
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: CASE_CONTROL
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: All patients are included in this study if they had been maintained on mechanical ventilation in excess of 3 weeks before respiratory care center admission, and all previous weaning attempts had failed.

Patients are eligible for respiratory care center admission : hemodynamics stability, no vasoactive drug infusion for 24 hours or more before transfer, stable oxygen requirements(FIO2\<40%,PERP\<10 cmH2O), no hepatic failure, no requirement for surgical intervention within the 2 weeks, .

Brief summary: 1. purpose of study: optimal minute could be the prediction of successful weaning and become the new weaning parameter.
2. study design: inclusion criteria: investigators will perform this study at our respiratory care center. Patients who had been maintained on mechanical ventilator in excess of 3 weeks before respiratory care center admission and all previous weaning attempts had ailed.

   Exclusion criteria: Patients do not have spontaneous breath. Terminal cancer stage and unstable hemodynamics condition.
3. study duration: 2016/01/01\~12/31

Detailed description: Investigators will preform this study at our respiratory care center. Initially, Investigators collected all physiological parameters and baseline characteristics of patients with prolong mechanical ventilator. Investigators use Gold-Galileo ventilator and patients use adaptive support ventilation mode. In adaptive support ventilation, the clinician enters a target minute volume , using a parameter called minute ventilation percentage. The minute ventilation percentage setting be initially set at 100% (the 100%minute ventilation setting), which provides a target minute ventilation of 0.1 L/min/kg of ideal body weight . Investigators observed respiratory frequency of patients, the minute ventilation percentage was increased every 5 min until the mandatory breath began to appear and spontaneous rate is zero. If the minute ventilation percentage had exceeded 250%, but patients do not have mandatory rate appeared, the optimal minute ventilation of the patient is means above 250%. Investigators also measure other weaning parameters. Finally, Investigators analyze the prediction of optimal minute ventilation as a weaning parameter.

Eligibility criteria: Inclusion Criteria:

* patients who had been maintained on mechanical ventilation in excess of 3 weeks before respiratory care center admission and all previous weaning attempts had failed.

Exclusion Criteria:

* Patients do not have spontaneous breath. Patients do not use invasive mechanical ventilator. Terminal cancer stage and hemodynamics unstable.

Primary outcomes:
measure: The prediction of optimal minute ventilation as successful weaning parameters in patients with prolong mechanical ventilator.
timeFrame: 2016/01/01~2016/12/31,1 year
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
affiliation: Taipei Tzuchi hospital , Buddhist Tzu chi medical foundation
name: YaRu Liang
role: STUDY_CHAIR
References:
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