Clinical trial NCT05247632: Precision Nutrition and Food Safety for Dietary Prevention of Chronic Disease Study
Official title: Precision Nutrition and Food Safety for Dietary Prevention of Chronic Disease (PNFS) Study
Study type: OBSERVATIONAL
Overall status: ACTIVE_NOT_RECRUITING
Conditions: Chronic Diseases
Keywords: Food safety
Food nutrition
Food contaminant
Mult-omics
Chronic diseases
Lead sponsor: Zhejiang University
Sponsor class: OTHER
Collaborators: name: Lanxi Red Cross Hospital
name: Lanxi Hospital of Traditional Chinese Medicine
First posted: 2022-02-21
Enrollment: 2290
Sex: ALL
Minimum age (years): 45
Maximum age (years): 75
Standard ages: ADULT
OLDER_ADULT
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: Subjects are eligible residents from 10 government-administered units including 7 urban towns and 3 rural villages of Jinhua, China.

Brief summary: The associations between food nutrition and safety factors with the risk of chronic diseases are still unclear. This study is conducted in Jinhua, a city with a high prevalence of chronic diseases in China, to assess relations between food nutrition and safety factors and chronic diseases.

Detailed description: Investigations of associations of food nutrition and safety factors with the risk of chronic diseases are limited and studies in China are still lacking. The investigators aim to collect basic characteristics of participants at baseline, including sex, age, smoking, exercise, marriage, education level, dietary factors, and so on, to assess the association of food nutrition and safety factors including various food items, dietary fatty acids, and internal biomarkers of food contaminants such as acrylamide and 3-MCPD with various chronic diseases in a Chinese middle-aged and elderly population. We will use multi-omics technology to investigate the causal mechanisms. Results from this study will be valuable for chronic diseases prevention in China.

Eligibility criteria: Inclusion Criteria:

* Subject aged ≥45 and ≤74 years old
* Subject has complete data on diet and follow-up time

Exclusion Criteria:

had the major illness that had made personal life disabled

Primary outcomes:
measure: Numbers of participants with metabolic syndrome
timeFrame: From entry into the study baseline:2018 until 2023
measure: Numbers of participants with obesity
timeFrame: From entry into the study baseline:2018 until 2023
measure: Numbers of participants with diabetes
timeFrame: From entry into the study baseline:2018 until 2023
Secondary outcomes:
measure: Numbers of participants died
timeFrame: From entry into the study baseline:2018 until 2023
measure: Numbers of participants with cardiovascular diseases
timeFrame: From entry into the study baseline:2018 until 2023
Other outcomes:
measure: Numbers of participants with fatty liver disease
timeFrame: From entry into the study baseline:2018 until 2023
Locations:
city: Lanxi
country: China
facility: Lanxi Red Cross Hospital
state: Zhejiang
city: Jinhua
country: China
facility: Lanxi Hospital of Traditional Chinese Medicine
Study officials:
affiliation: Lanxi Red Cross Hospital
name: Weifang Zheng
role: STUDY_DIRECTOR
affiliation: Zhejiang University
name: Jingjing Jiao
role: PRINCIPAL_INVESTIGATOR
affiliation: Zhejiang University
name: Yu Zhang
role: PRINCIPAL_INVESTIGATOR
affiliation: Zhejiang University
name: Pan Zhuang
role: PRINCIPAL_INVESTIGATOR
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