Clinical trial NCT05219578: RTX-224 Monotherapy in Patients With Solid Tumors
Official title: A Phase 1/2 Study of RTX-224 for the Treatment of Patients With Advanced Solid Tumors
Study type: INTERVENTIONAL
Overall status: TERMINATED
Phase: PHASE1
PHASE2
Conditions: Non Small Cell Lung Cancer
Cutaneous Melanoma
Head and Neck Squamous Cell Carcinoma
Urothelial Carcinoma
TNBC - Triple-Negative Breast Cancer
Keywords: Solid Tumor, Advanced Solid Tumors
Lead sponsor: Rubius Therapeutics
Sponsor class: INDUSTRY
First posted: 2022-02-02
Enrollment: 7
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NON_RANDOMIZED
Intervention model: SEQUENTIAL
Primary purpose: TREATMENT

Brief summary: This is an open-label, multidose, first-in-human (FIH), Phase 1/2 study of RTX-224 for the treatment of patients with relapsed or refractory (R/R), or locally advanced solid tumors.

Detailed description: This is a Phase 1, open label, multicenter, multidose, first-in-human (FIH), dose escalation and expansion to determine the safety and tolerability, recommended phase 2 dose, and pharmacology, and antitumor activity of RTX-224 in adult patients with persistent, recurrent, or metastatic, unresectable solid tumors. The study will include a monotherapy dose escalation phase followed by an expansion phase.

Eligibility criteria: Inclusion Criteria:

* Signed written informed consent obtained prior to study procedures Patients ≥18 years with an ECOG of 0 or 1
* R/R, or locally advanced, unresectable, and histologically or cytologically confirmed

  (a) NSCLC, (b) cutaneous melanoma, (c) HNSCC, (d) UC, or (e) TNBC, which are refractory to or otherwise ineligible for treatment with standard-of-care treatments
* Prior therapy in each disease setting must include the following:

  * NSCLC: Patients must have experienced disease progression following platinum-containing chemotherapy and a PD-1 or PD-L1 inhibitor. Patients with EGFR, ALK, ROS-1, or other actionable mutations should have previously received or been ineligible for therapies targeting their respective mutation(s).
  * Cutaneous melanoma: Patients must have experienced disease progression following a PD-1 or PD-L1 inhibitor. Patients with V600E mutations should have previously received or been ineligible for approved BRAF inhibitor or MEK inhibitor therapy.
  * HNSCC: Patients must have experienced disease progression following platinum-based combination chemotherapy and a PD-1 or PD-L1 inhibitor.
  * UC: Patients must have experienced disease progression following platinum-based combination chemotherapy and a PD-1 or PD-L1 inhibitor.
  * TNBC: Patients must have experienced disease progression following single-agent or combination chemotherapy. Patients with BRCA1/2 mutations should have previously received or been ineligible for an approved PARP inhibitor; patients who are PD-L1 positive should have received or been ineligible for an approved PD-1 or PD-L1 inhibitor.
* Disease must be measurable per Response Evaluation Criteria
* The shorter of 28 days or 5 half-lives must have elapsed since the completion of prior therapy, before initiation of study treatment.
* Adequate Organ Function as Defined by the protocol:

  * AST and ALT ≤3 × the upper limit of normal (ULN) Except in documented cases of Gilbert syndrome, total bilirubin ≤1.5 × ULN
  * Serum albumin ≥2.5 g/dL
  * Serum or plasma creatinine ≤1.5 × ULN and/or glomerular filtration rate ≥50 mL/min/1.73 calculated by the Cockcroft-Gault formula
  * Absolute neutrophil count ≥1 × 103/μL
  * Platelet count ≥100 × 103/μL
  * Hemoglobin ≥9 g/dL

Exclusion Criteria:

* Patient has central nervous system (CNS) involvement. If the patient fulfills the following 3 criteria, she/he is eligible for the trial after consultation with the Sponsor Medical Monitor.
* Completed prior therapy for CNS metastases (radiation and/or surgery)
* CNS tumor(s) is clinically stable at the time of enrollment
* Patient does not require corticosteroid or antiepileptic therapy for management of CNS metastases
* Known hypersensitivity to any component of study treatment or excipients.
* Positive antibody screen using institution's standard type and screen test.
* Clinically significant, active and uncontrolled infection, including human immunodeficiency virus (HIV), Hepatitis B virus (HBV), or Hepatitis C virus (HCV).

Primary outcomes:
measure: Safety Assessment by rate of Adverse Events (AEs)
timeFrame: up to 30 months
measure: Dose limiting toxicities (DLTs) of RTX-224
timeFrame: up to 30 months
Secondary outcomes:
measure: Pharmacodynamics (PD) of RTX-224
timeFrame: up to 30 months
measure: Pharmacokinetics (PK) of RTX-224
timeFrame: up to 30 months
measure: Pharmacokinetics (PK) of RTX-224
timeFrame: up to 30 months
measure: Anti-tumor activity of RTX-224
timeFrame: up to 30 months
measure: Anti-tumor activity of RTX-224
timeFrame: up to 30 months
measure: Anti-tumor activity of RTX-224
timeFrame: up to 30 months
measure: Anti-tumor activity of RTX-224
timeFrame: up to 30 months
measure: Anti-tumor activity of RTX-224
timeFrame: up to 30 months
Other outcomes:
Locations:
city: Scottsdale
country: United States
facility: HonorHealth
state: Arizona
city: Los Angeles
country: United States
facility: USC Norris Comprehensive Cancer Center
state: California
city: San Francisco
country: United States
facility: University of California San Francisco Health
state: California
city: Nashville
country: United States
facility: Sarah Cannon Research Institute
state: Tennessee
city: Fairfax
country: United States
facility: Virginia Cancer Specialists
state: Virginia
Study officials:
References: