louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT05799937: Effect of Smoking on Periapical Healing After NSRCT
Official title: To Evaluate the Effect of Smoking on Periapical Healing After Non Surgical Root Canal Treatment- a Prospective Cohort Study
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Apical Periodontitis
Keywords: apical periodontitis, periapical pathology, smokers, non-smokers
Lead sponsor: Postgraduate Institute of Dental Sciences Rohtak
Sponsor class: OTHER
First posted: 2023-04-05
Enrollment: 116
Sex: ALL
Minimum age (years): 18
Maximum age (years): 80
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Smokers of age 18 years (male/female) and above having apical periodontitis with age and gender matched controls will be enrolled in the study.

Brief summary: Goal of this prospective observational study is determine effect of smoking on periapical healing after NSRCT. Population includes systemically healthy smokers with radiographic evidence of apical periodontitis will be recruited and compared with same type of population of non smokers after non surgical root canal treatment intervention in both the groups. Outcome will be assessed using periapical index scoring system at 6 and 12 months follow up period

Detailed description: The clinical and radiological success of primary non-surgical endodontic treatment in smoker \& nonsmoker patients will be compared between both groups and smoking cessation effect on periapical healing will be assessed.

The correlation between the self-reported smoking status \& smoking status by urine analysis

Eligibility criteria: Inclusion Criteria:

* systemically healthy patients of age 18 years and above, known current smoker patient , a non-smoker or former smoker patient ,should have at least minimum 8 teeth in oral cavity, requiring periapical radiographs of teeth with periapical pathosis

Exclusion Criteria:

* Pregnant or patient having systemic disorders, those patients who are non-compliant and not maintaining oral hygiene, teeth requiring retreatment and having procedural errors. Teeth that are not suitable for rubber dam isolation, teeth that have advanced periodontal disease and having endo-perio lesions and, patients requiring endocarditis prophylaxis

Primary outcomes:
measure: Radiographic healing
timeFrame: 12 months
measure: Clinical Success
timeFrame: 12 month
Secondary outcomes:
Other outcomes:
Locations:
city: Rohtak
country: India
facility: PGIDS
state: Haryana
Study officials:
affiliation: Post Graduate Institute Of Dental Sciences,Rohtak
name: Dr. Sanjay Tewari, MDS
role: STUDY_DIRECTOR
References:
Clinical trial NCT03224637: Radiofrequency Neurotomy In Relieving Chronic Knee Pain
Official title: Fluoroscopic Guided Radiofrequency of Genicular Nerves for Pain Alleviation in Chronic Knee Osteoarthritis : A Single-blind Randomized Controlled Trial.
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Osteo Arthritis Knee
Pain, Chronic
Lead sponsor: Assiut University
Sponsor class: OTHER
First posted: 2017-07-21
Enrollment: 60
Sex: ALL
Minimum age (years): 30
Maximum age (years): 70
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: Osteoarthritis (OA) affects aged above 45 years. RF has been used for several painful conditions. There have been a few attempts to use RF current for the treatment of painful conditions of joints of the extremities. It was also used for the treatment of painful conditions of the hip joint.

Detailed description: Osteoarthritis (OA) is commonest chronic arthritis affecting patients usually aged above 45 years. OA decreased health-related quality of life and increased economic costs. Radiofrequency (RF), was used for the treatment of chronic pain unresponsive to conservative therapies. RF has been used for several painful conditions. There have been a few attempts to use RF current for the treatment of painful conditions of joints of the extremities. It was also used for the treatment of painful conditions of the hip joint.

Eligibility criteria: Inclusion Criteria:

* chronic arthritis according to the American College of Rheumatology criteria
* diagnosed radiologically patients in stage 3 and 4, according to the Kellgren-Lawrence classification

Exclusion Criteria:

* other causes of pain such as radiculopathy, neurological disorders, or intermittent claudication.
* patients receive intraarticular steroid or hyaluronic acids during previous three months.
* patients did previous knee surgery.
* Patients with general contraindication to the application of invasive intervention such as hemorrhage, coagulation disorder, systemic infection or local infection.
* patients with other connective tissue disease affecting the knee. And 6-psychiatric disorders.

Primary outcomes:
measure: pain assessment by VAS scale
timeFrame: 6 months
Secondary outcomes:
measure: patient satisfaction by Likert scale
timeFrame: 6 months
measure: patient disability by Western Ontario McMaster Universities OA index
timeFrame: 6 months
Other outcomes:
Locations:
city: Assiut
country: Egypt
facility: Emad Zarief Kamel Said
Study officials:
References:
citation: El-Hakeim EH, Elawamy A, Kamel EZ, Goma SH, Gamal RM, Ghandour AM, Osman AM, Morsy KM. Fluoroscopic Guided Radiofrequency of Genicular Nerves for Pain Alleviation in Chronic Knee Osteoarthritis: A Single-Blind Randomized Controlled Trial. Pain Physician. 2018 Mar;21(2):169-177.
Clinical trial NCT00190437: ANTEAB: a Study of Early Antibiotherapy in the ICU Management of Acute Exacerbations of COPD
Official title: ANTEAB: a Study of Early Antibiotherapy in the ICU Management of Acute Exacerbations of COPD
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE4
Conditions: Chronic Obstructive Lung Disease (COLD)
Keywords: Chronic Obstructive Lung Disease (COLD)
Randomized Clinical Trial
Antibiotics
Acute Exacerbation
Mechanical
Ventilation
Intensive Care
Length of Stay
Mortality
Lead sponsor: Assistance Publique - Hôpitaux de Paris
Sponsor class: OTHER
First posted: 2005-09-19
Enrollment: 520
Sex: ALL
Minimum age (years): 18
Maximum age (years): 70
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: Intensive Care Unit (ICU) admission for acute exacerbation of chronic obstructive lung disease (COLD) is a major cause of morbidity and mortality in such patients. Although bacterial of mortality in such patients. Although bacterial and or viral infections are considered as the major precipitating factor, the antibiotic strategy in this setting is unclear. The absence of overt infection remains controversial, and has not been adequately studied in patients admitted to the ICU. To assess the benefit ( or lack thereof ) of routine early systemic antibiotic therapy in patients with COLD admitted to the ICU.

The primary objective of the essay is to evaluate the effectiveness of the precocious antibiotic therapy on the length of the respiratory symptoms with the admitted patients in polyvalent medical intensive care of chronic obstructive lung disease ( COLD )

Detailed description: This is a multicenter, randomised, double-blind controlled trial, comparing amoxicillin-clavulanic acid administered for 7 days to a placebo.

Eligibility criteria: Inclusion Criteria:

* Patients included are those with documented or suspected COLD, exclusive of other bronchial or lung disease, and admitted for acute exacerbation, in the absence of overt sepsis or broncho-pneumonia, and having no other organ.

Exclusion Criteria:

* Patients recently hospitalised, having received antibiotics since more than 24h, or on long-term steroids will not be included

Primary outcomes:
measure: A 20% reduction of the duration of clinical symptoms of exacerbation is expected
timeFrame: during de study
Secondary outcomes:
measure: The incidence of documented infection, antibiotic use, the proportion of patients having infection with resistant bacteria
timeFrame: during the study
Other outcomes:
Locations:
city: Paris
country: France
facility: Assistance Publique-Hopitaux de Paris
state: Ile de France
city: Creteil
country: France
facility: Hopital Henri Mondor
state: Val de Marne
Study officials:
affiliation: Assistance Publique - Hôpitaux de Paris
name: Christian BRUN-BUISSON, Pr,MD,PhD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT06222437: Semaglutide and Polycystic Ovarian Syndrome: an Emerging Treatment Strategy
Official title: Semaglutide and Polycystic Ovarian Syndrome: an Emerging Treatment Strategy
Study type: INTERVENTIONAL
Overall status: NOT_YET_RECRUITING
Phase: PHASE1
Conditions: Polycystic Ovary Syndrome
Lead sponsor: Methodist Health System
Sponsor class: OTHER
First posted: 2024-01-24
Enrollment: 85
Sex: FEMALE
Minimum age (years): 18
Maximum age (years): 45
Standard ages: ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: TREATMENT

Brief summary: The purpose of this study is to investigate the effect of semaglutide in women with Polycystic Ovarian Syndrome(PCOS ) and determine potential therapeutic benefits.

Detailed description: The study mainly focused for the following objectives:

To determine the effect of semaglutide on ovulation and menstrual regularity. To determine the effect of semaglutide on androgen levels, namely testosterone, sex hormone binding globulin, and changes in hirsutism.

To determine changes in weight, body mass index (BMI), and Glycated Hemoglobin( HbA1c) with semaglutide therapy.

Eligibility criteria: Inclusion Criteria:

* Age 18-45
* Body mass index(BMI) \> 30
* Diagnosis of PCOS
* Normal thyroid stimulating hormone, prolactin, follicle-stimulating hormone (FSH), estradiol, and normal progesterone

Exclusion Criteria:

* Medications excluded: any hormone-containing contraceptive - oral contraceptive pills, Progesterone-only pill, depo-provera, oral provera, progesterone-containing intrauterine contraceptive device
* Letrozole, clomiphene citrate, FSH therapy
* Androgen receptor blockers
* 5α reductase inhibitors
* Insulin
* Hysterectomy
* Endometrial ablation

Primary outcomes:
measure: Number of appropriate weekly dose
timeFrame: 4 weeks
measure: Number of days on therapy
timeFrame: 4 weeks
Secondary outcomes:
measure: measure the Weight in kilograms
timeFrame: 4 weeks
measure: Numbers of days with exercise changes
timeFrame: 4 weeks
Other outcomes:
Locations:
city: Dallas
country: United States
facility: Clinical Research Institute at Methodist Health System
state: Texas
Study officials:
References:
Clinical trial NCT02817737: Pre-operative Radiological Measurement to Assess Femur Rotational Alignment
Official title: Pre-operative Radiological Measurement of Proximal Tibia Angle to Assess Femur Rotational Alignment in Total Knee Arthroplasty
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Total Knee Replacement
Lead sponsor: Xi'an Honghui Hospital
Sponsor class: OTHER
First posted: 2016-06-29
Enrollment: 33
Sex: FEMALE
Minimum age (years): 40
Maximum age (years): 80
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: Chinese female patients with primary varus knee OA, scheduled for primary TKAs

Brief summary: Purpose: This study outlines the benefits of the proximal tibia angle (PTA) in evaluation of the pre-operative individual condylar twist angle (CTA) in total knee arthroplasty.

Methods: Condylar twist angle and proximal tibia angle were obtained from 33 female healthy participants using computed tomography (CT). The CTA, angle between clinical transepicondylar axis and posterior condylar line were measured. The PTA is the angle formed between the mechanical axis of the tibia and tibia plateau line. The correlation between the CTA and the PTA was analyzed statistically with the linear regression.


Eligibility criteria: Inclusion Criteria:

* Osteoarthritis Varus knee deformity

Exclusion Criteria:

* Rheumatoid arthritis valgus knee OA previous knee surgeries posttraumatic arthritis

Primary outcomes:
measure: proximal tibia angle (PTA)
timeFrame: Four months
Secondary outcomes:
measure: Condylar twist angle (CTA)
timeFrame: Four months
Other outcomes:
Locations:
city: Xi'an
country: China
facility: Honghui Hospital
state: Shanxi
city: Xi'an
country: China
facility: Hong-hui Hospital
Study officials:
affiliation: Honghui Hospital
name: Jianbing Ma, MD
role: STUDY_DIRECTOR
References:
citation: Kanekasu K, Kondo M, Kadoya Y. Axial radiography of the distal femur to assess rotational alignment in total knee arthroplasty. Clin Orthop Relat Res. 2005 May;(434):193-7. doi: 10.1097/01.blo.0000156819.24866.8b.
citation: Savin L, Botez P, Mihailescu D, Predescu V, Grierosu C. Pre-operative radiological measurement of femoral rotation for prosthetic positioning in total knee arthroplasty. Int Orthop. 2016 Sep;40(9):1855-60. doi: 10.1007/s00264-015-3110-2. Epub 2016 Jan 23.
citation: Kobayashi H, Aratake M, Akamatsu Y, Mitsugi N, Taki N, Saito T. Reproducibility of condylar twist angle measurement using computed tomography and axial radiography of the distal femur. Orthop Traumatol Surg Res. 2014 Dec;100(8):885-90. doi: 10.1016/j.otsr.2014.07.025. Epub 2014 Nov 20.
Clinical trial NCT03331237: Sparing Diaphragm; ISO Block Versus Low Volume Scalene Block
Official title: Shoulder Analgesia Sparing Diaphragm; ISO Block Versus Low Volume Scalene Block. A Randomized Controlled Double Blind Study
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Shoulder Arthropathy Associated With Other Conditions
Lead sponsor: Healthpoint Hospital
Sponsor class: OTHER
First posted: 2017-11-06
Enrollment: 72
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: PREVENTION

Brief summary: For shoulder analgesia, both ISO block and low volume scalene (LVS) block (using 5 ml of local anesthetics) are suggested to have a low incidence of hemi-diaphragmatic pariesis (HDP).

The aim of this study was to compare the incidence of HDP and the analgesic efficacy of the LVS block versus ISO block.


Eligibility criteria: Inclusion Criteria:

* patients who were scheduled for arthroscopic shoulder surgery

Exclusion Criteria:

* aged \<18y
* BMI \>35,
* ASA greater \>III,
* an infection at the injection site
* has a contraindication for laryngeal mask or the medications used in this study.

Primary outcomes:
measure: hemi-diaphragmatic pariesis
timeFrame: 2-4 hours
Secondary outcomes:
measure: analgesic efficacy (block success)
timeFrame: 2-4 hours
measure: patient satisfaction
timeFrame: 24 hours
measure: duration of analgesia
timeFrame: 24 hours
measure: total morphine dose
timeFrame: 24 hours
Other outcomes:
Locations:
city: Abu Dhabi
country: United Arab Emirates
facility: Healthpoint Hospital
Study officials:
References:
citation: Taha AM, Yurdi NA, Elahl MI, Abd-Elmaksoud AM. Diaphragm-sparing effect of the infraclavicular subomohyoid block vs low volume interscalene block. A randomized blinded study. Acta Anaesthesiol Scand. 2019 May;63(5):653-658. doi: 10.1111/aas.13322. Epub 2019 Jan 30.
Clinical trial NCT04497337: The Superficial Lesions in the Peri-auricular Region
Official title: The Superficial Lesions in the Peri-auricular Region; Retrospective Study
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Superficial Cyst or Mass and Sinus on and Around the Ear
Lead sponsor: Sohag University
Sponsor class: OTHER
First posted: 2020-08-04
Enrollment: 70
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Intervention model description: Data included in this descriptive retrospective study were collected from records of 70 patients with superficial lesions around the auricle, i.e., periauricular (preauricular, auricular, and postauricular) during the period extending between 2017 and 2019, who were primarily diagnosed and operated
Primary purpose: TREATMENT

Brief summary: Superficial lesions on and around the ear are uncommon with many differential diagnoses and different characteristic histopathologic features. The purpose of this study was to describe a series of peri-auricular superficial lesions and characterize the distinctive types of these lesions.

Detailed description: Data included in this descriptive retrospective study were collected from records of 70 patients with superficial lesions around the auricle, i.e., periauricular (preauricular, auricular, and postauricular) during the period extending between 2017 and 2019, who were primarily diagnosed and operated. Data were retrieved, reviewed, and analyzed. The primary analysis outcome measures were patient history (age, gender, complaint, medical advice clinic, and associated medical diseases), lesions examination (site, laterality, clinical presentation, and the number of lesions). Also, the needed investigations for diagnosis, type of intervention, postoperative patient satisfaction were evaluated. Evaluation of the patients' follow up was done.

Eligibility criteria: Inclusion Criteria:

* Patients with superficial lesions around the auricle, i.e., periauricular (preauricular, auricular, and postauricular) operated during the period extending between 2017 and 2019
* Available full demographic, clinical and histopathological data

Exclusion Criteria:

* deep lesions involving parotid or parapharyngeal space
* Missed demographic, clinical and histopathological data

Primary outcomes:
measure: clinical and Histopathlogical types of superficial lesion around the ear
timeFrame: Cases operated between in the previous 3 years from 2017 and 2019
Secondary outcomes:
Other outcomes:
Locations:
city: Sohag
country: Egypt
facility: Sohag University
Study officials:
affiliation: Nasr City, Eastern Avenue, University Street, Sohag, Egypt
name: Sohag University hospital
role: STUDY_DIRECTOR
References:
Clinical trial NCT02620137: Maintenance of Multivitamin Supplements After Sleeve Gastrectomy
Official title: Maintenance of Multivitamin Supplements After Sleeve Gastrectomy
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE3
Conditions: Iron Deficiency Anemia
Lead sponsor: Hospital General Universitario Elche
Sponsor class: OTHER
First posted: 2015-12-02
Enrollment: 80
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: PREVENTION

Brief summary: A prospective randomized study of patients undergoing a laparoscopic sleeve gastrectomy was performed. Patients were randomized into 2 groups: those patients receiving the multivitamin supplement during 3 months (Group 1), and those receiving the supplement during 12 months (Group 2). Laboratory data were recorded: vitamins and oligoelements at 3, 6 and 12 months after surgery.

Detailed description: A prospective randomized study of patients undergoing a laparoscopic sleeve gastrectomy was performed. Patients were randomized into 2 groups: those patients receiving the multivitamin supplement (Multicentrum, Pfizer, 1 tablet/day) during 3 months (Group 1), and those receiving the supplement during 12 months (Group 2). Laboratory data were recorded: vitamins (D, B12 and folic acid) and oligoelements (calcium, iron, phosphorus, magnesium and zinc) at 3, 6 and 12 months after surgery.

Eligibility criteria: Inclusion Criteria:

* patients undergoing laparoscopic sleeve gastrectomy
* BMI \>40 Kg/m2
* BMI \> 35 Kg/m2 with the presence of comorbidities associated to obesity

Exclusion Criteria:

* documented gastroesophageal reflux
* patients with uncontrolled psychiatric disorders
* active infections or malignancies
* any other concomitant pathology considered as a contraindication for bariatric surgery.

Primary outcomes:
measure: Iron serum levels
timeFrame: 12 months
Secondary outcomes:
measure: Calcium serum levels
timeFrame: 12 months
measure: Vitamin B12 serum levels
timeFrame: 12 months
measure: Folic acid serum levels
timeFrame: 12 months
Other outcomes:
Locations:
Study officials:
affiliation: Department of Surgery
name: Manuel Duran
role: STUDY_DIRECTOR
References:
citation: Ruiz-Tovar J, Llavero C, Zubiaga L, Boix E; OBELCHE group. Maintenance of Multivitamin Supplements After Sleeve Gastrectomy. Obes Surg. 2016 Oct;26(10):2324-30. doi: 10.1007/s11695-016-2084-5.
Clinical trial NCT03501537: Association of Keratinised Mucosa Around Implants and Teeth With Peri-implant/Periodontal Disease and Soft Tissue Conditioning
Official title: Soft Tissue Conditioning to for the Treatment of Peri-implantitis in the Lack of Keratinised Mucosa
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Peri-Implantitis
Soft Tissue
Bone Gain
Lead sponsor: Center of Implantology, Oral and Maxillofacial Surgery, Badajoz, Spain
Sponsor class: OTHER
First posted: 2018-04-18
Enrollment: 37
Sex: ALL
Minimum age (years): 18
Maximum age (years): 80
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: NA
Intervention model: SINGLE_GROUP
Intervention model description: Single-prospective one-arm study
Primary purpose: TREATMENT

Brief summary: Lack of keratinised mucosa around dental implants and teeth is associated with plaque accumulation and worse tissue conditions. However, there is lack of data on the influence of the presence/lack of keratinised mucosa on the periodontal condition. Hence, soft tissue conditioning by grafting with a gingival graft is aimed at improving the quality of the peri-implant conditions


Eligibility criteria: Inclusion Criteria:

* Partial edentulous patients with adjacent teeth
* Lack of keratinised mucosa
* Healthy patient

Exclusion Criteria:

* Pregnancy
* Complete edentulous patients
* Patients taking any medication
* Smokers

Primary outcomes:
measure: Peri-implant conditions
timeFrame: 12 months after implant loading
Secondary outcomes:
measure: Association of keratinised mucosa/gingiva with periodontal and peri-implant conditions
timeFrame: 12 months after implant loading
Other outcomes:
Locations:
city: Badajoz
country: Spain
facility: Centro de Implantologia Cirugia Oral y Maxilofacial
Study officials:
References:
citation: Parpaiola A, Cecchinato D, Toia M, Bressan E, Speroni S, Lindhe J. Dimensions of the healthy gingiva and peri-implant mucosa. Clin Oral Implants Res. 2015 Jun;26(6):657-62. doi: 10.1111/clr.12359. Epub 2014 Feb 26.
citation: Monje A, Blasi G. Significance of keratinized mucosa/gingiva on peri-implant and adjacent periodontal conditions in erratic maintenance compliers. J Periodontol. 2019 May;90(5):445-453. doi: 10.1002/JPER.18-0471. Epub 2018 Dec 7.