Clinical trial NCT02444832: Multicenter Retrospective Registry of Anterior Communicating Artery Aneurysms With Endovascular Therapy
Official title: Multicenter Retrospective Registry of Anterior Communicating Artery Aneurysms With Endovascular Therapy
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Intracranial Aneurysm
Anterior Communicating Artery Aneurysm
Cerebral Aneurysm
Aneurysm, Ruptured
Lead sponsor: Hospital Clinic of Barcelona
Sponsor class: OTHER
Collaborators: name: Hospitales Universitarios Virgen del Rocío
name: Hospital Universitario Reina Sofia de Cordoba
First posted: 2015-05-15
Enrollment: 300
Sex: ALL
Minimum age (years): 18
Maximum age (years): 80
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: CASE_ONLY
Time perspective: RETROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Patients with Communicating Artery Aneurysm treated with endovascular coiling.

Brief summary: Based on the anatomical features of the anterior Communicating artery complex, the investigators will analyze the outcome of the ACoA aneurysms treated by endovascular therapy.

The most common site of intracranial aneurysms is the anterior communicating artery (AcomA). AcomA aneurysms account for approximately one-fourth of all intracranial aneurysms.

Recent publications have addressed specifically the endovascular treatment of AcoA aneurysms. Furthermore, detailed anatomic characteristics and the effects of the multiple variations of the anterior communicating artery complex have scarcely been reported.

The hemodynamic factors play a fundamental role in the adequate treatment of aneurismal coiling.

The objective of our registry is to analyze the impact of morphological configuration of the anterior communicating artery complex and the results of coil embolization in AcoA aneurysms


Eligibility criteria: Inclusion Criteria:

* Patient with Anterior Communicating Artery Aneurysm treated with endovascular coiling.

Exclusion Criteria:

* Patients without imaging follow up of at least 12 months after endovascular treatment.

Primary outcomes:
measure: Effective Aneurysm Coiling (no residual cerebral aneurysm)
timeFrame: 1 year
Secondary outcomes:
measure: All Cause Mortality
timeFrame: 1 year
measure: Neurological Outcome (classified with the Glasgow Outcome Scale, Rankin Scale)
timeFrame: 1 year
measure: Procedural device-related serious adverse events
timeFrame: 1 year
Other outcomes:
Locations:
city: Barcelona
country: Spain
facility: Hospital Clinic
Study officials:
affiliation: Hospital Clinic of Barcelona
name: Federico Zarco, MD
role: PRINCIPAL_INVESTIGATOR
References:
citation: Elias T, Ogungbo B, Connolly D, Gregson B, Mendelow AD, Gholkar A. Endovascular treatment of anterior communicating artery aneurysms: results of clinical and radiological outcome in Newcastle. Br J Neurosurg. 2003 Jun;17(3):278-86. doi: 10.1080/0268869031000153251.
citation: Moret J, Pierot L, Boulin A, Castaings L, Rey A. Endovascular treatment of anterior communicating artery aneurysms using Guglielmi detachable coils. Neuroradiology. 1996 Nov;38(8):800-5. doi: 10.1007/s002340050352.
citation: Birknes JK, Hwang SK, Pandey AS, Cockroft K, Dyer AM, Benitez RP, Veznedaroglu E, Rosenwasser RH. Feasibility and limitations of endovascular coil embolization of anterior communicating artery aneurysms: morphological considerations. Neurosurgery. 2006 Jul;59(1):43-52; discussion 43-52. doi: 10.1227/01.NEU.0000219220.25721.B9.
citation: Molyneux AJ, Kerr RS, Yu LM, Clarke M, Sneade M, Yarnold JA, Sandercock P; International Subarachnoid Aneurysm Trial (ISAT) Collaborative Group. International subarachnoid aneurysm trial (ISAT) of neurosurgical clipping versus endovascular coiling in 2143 patients with ruptured intracranial aneurysms: a randomised comparison of effects on survival, dependency, seizures, rebleeding, subgroups, and aneurysm occlusion. Lancet. 2005 Sep 3-9;366(9488):809-17. doi: 10.1016/S0140-6736(05)67214-5.