Clinical trial NCT01897532: Cardiovascular and Renal Microvascular Outcome Study With Linagliptin in Patients With Type 2 Diabetes Mellitus (CARMELINA)
Official title: CARMELINA: A Multicenter, International, Randomized, Parallel Group, Double-blind, Placebo-controlled, Cardiovascular Safety and Renal Microvascular Outcome Study With Linagliptin, 5 mg Once Daily in Patients With Type 2 Diabetes Mellitus at High Vascular Risk
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE4
Conditions: Diabetes Mellitus, Type 2
Lead sponsor: Boehringer Ingelheim
Sponsor class: INDUSTRY
Collaborators: name: Eli Lilly and Company
First posted: 2013-07-12
Enrollment: 6991
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The aim of the study is to investigate the longterm impact on cardiovascular morbidity, mortality and renal function of treatment with linagliptin in a selected population of patients with Type 2 diabetes mellitus (T2DM) and to compare outcomes against placebo, on a background of standard of care.


Eligibility criteria: Inclusion criteria:

1. Documented diagnosis of T2DM before visit 1(screening).
2. Male or female patients who are drug-naïve or pre-treated with any antidiabetic background medication, excluding treatment with Glucagon-like Peptide 1 (GLP-1) receptor agonists, Dipeptidyl-peptidase 4 (DPP-4) inhibitors or Sodium Glucose Linked Transporter 2 (SGLT-2) inhibitors if =\> consecutive 7 days.
3. Stable antidiabetic background medication (unchanged daily dose) for at least 8 weeks prior to randomization. If insulin is part of the background therapy, the average daily insulin dose should not have changed by more than 10% within the 8 weeks prior to randomization compared with the daily insulin dose at randomization.
4. HbA1c of =\> 6.5% and \<= 10.0% at Visit 1 (screening)
5. Age =\> 18 years at Visit 1(screening). For Japan only: Age =\> 20 years at Visit 1
6. Body Mass Index (BMI) \<= 45 kg/m2 at Visit 1 (screening)
7. Signed and dated written informed consent by date of Visit 1(screening) in accordance with Good Clinical Practice (GCP) and local legislation prior to any study related procedure
8. High risk of cardiovascular (CV) events defined by: 1) albuminuria (micro or macro) and previous macrovascular disease and/or 2) impaired renal function with predefined Urine Albumin Creatinine Ratio (UACR)

Exclusion criteria:

1. Type 1 diabetes mellitus.
2. Treatment (=\> 7 consecutive days) with GLP-1 receptor agonists, other DPP-4 inhibitors or SGLT-2 inhibitors prior to informed consent. Note: This also includes clinical trials where these antidiabetic drugs have been provided to the patient.
3. Active liver disease or impaired hepatic function, defined by serum levels of either Alanine Transaminase (ALT) (SGPT), Aspartate transaminase (AST) (SGOT), or alkaline phosphatase (AP) =\> 3 x upper limit of normal (ULN) as determined at Visit 1.
4. Estimated Glomerular filtration Rate (eGFR) \<15 ml/min/1.73 m2 (severe renal impairment or End Stage Renal Disease (ESRD), Modification of Diet in Renal Disease (MDRD) formula), as determined during screening at Visit 1 and/or the need for maintenance dialysis.
5. Any previous (or planned within next 12 months) bariatric surgery (open or laparoscopic) or intervention (gastric sleeve).
6. Pre-planned coronary artery re-vascularisation (PCI, CABG) or any previous PCI and/or CABG \<= 2 months prior informed consent.
7. Known hypersensitivity or allergy to the investigational products or its excipients.
8. Any previous or current alcohol or drug abuse that would interfere with trial participation in the opinion of the investigator.
9. Participation in another trial with an investigational drug ongoing or within 2 months prior to visit 1 (screening).
10. Pre-menopausal women (last menstruation = 1 year prior to informed consent) who are nursing or pregnant, are of child-bearing potential and are not practicing an acceptable method of birth control (acceptable methods of birth control include tubal ligation, transdermal patch, intra uterine devices/systems (IUDs/IUSs), oral, implantable or injectable contraceptives, sexual abstinence (if allowed by local authorities), double barrier method and vasectomised partner) or do not plan to continue using acceptable method of birth control throughout the study and do not agree to submit to periodic pregnancy testing during participation in the trial.
11. Patients considered unreliable by the investigator concerning the requirements for follow up during the study and/or compliance with study drug administration, have a life expectancy less than 5 years for non-CV causes, or have cancer other than non-melanoma skin cancer within last 3 years, or has any other condition than mentioned which in the opinion of the investigator, would not allow safe participation in the study.
12. Acute coronary syndrome (ACS), diagnosed \<= 2 months prior to visit 1 (screening).
13. Stroke or Transient Ischemic Attack (TIA) \<= 3 months prior to visit 1 (screening).

Primary outcomes:
measure: Time to the First Occurrence of Any of the Following Adjudication-confirmed Components of the Primary Composite Endpoint 3-point Major Adverse Cardiovascular (CV) Events (3-point MACE): CV Death, Non-fatal Myocardial Infarction (MI) or Non-fatal Stroke.
timeFrame: From randomization to individual end of observation; up to 4.3 years
Secondary outcomes:
measure: Time to the First Occurrence of Any of the Following Adjudication-confirmed Components: Renal Death, Sustained End Stage Renal Disease (ESRD), or Sustained Decrease of 40% or More in Estimated Glomerular Filtration Rate (eGFR).
timeFrame: From randomization to individual end of observation; up to 4.3 years
Other outcomes:
Locations:
city: Huntsville
country: United States
facility: Longwood Research
state: Alabama
city: Scottsboro
country: United States
facility: Scottsboro Quick Care Clinic
state: Alabama
city: Tuscumbia
country: United States
facility: Office of Dr. Terence T. Hart MD
state: Alabama
city: Glendale
country: United States
facility: Arrowhead Health Centers
state: Arizona
city: Phoenix
country: United States
facility: Precision Trials, LLC
state: Arizona
city: Harrisburg
country: United States
facility: Harrisburg Family Medical Center
state: Arkansas
city: Little Rock
country: United States
facility: Cardiology and Medicine Clinic
state: Arkansas
city: Little Rock
country: United States
facility: Little Rock Diagnostic Clinic
state: Arkansas
city: Bonita
country: United States
facility: Kaiser Permanente - San Diego, Bonita
state: California
city: Concord
country: United States
facility: John Muir Physician Network Clinical Research Center
state: California
city: Fresno
country: United States
facility: Valley Research
state: California
city: Loma Linda
country: United States
facility: VA Loma Linda Healthcare System
state: California
city: Long Beach
country: United States
facility: Long Beach Center for Clinical Research
state: California
city: Los Angeles
country: United States
facility: Clearview Medical Research, LLC
state: California
city: Los Angeles
country: United States
facility: National Research Institute
state: California
city: Los Gatos
country: United States
facility: Office of Dr. Richard S. Cherlin
state: California
city: Los Osos
country: United States
facility: Coastal Medical Research Group
state: California
city: Modesto
country: United States
facility: Novo Research, Incorporated
state: California
city: North Hollywood
country: United States
facility: Providence Clinical Research
state: California
city: Northridge
country: United States
facility: Northridge Clinical Research Inc.
state: California
city: Oceanside
country: United States
facility: Carr Cardiology
state: California
city: Sacramento
country: United States
facility: Center for Clinical Trials of Sacramento, Incorporated
state: California
city: San Dimas
country: United States
facility: North America Research Institute
state: California
city: San Jose
country: United States
facility: Trinitas Research, Incorporated
state: California
city: Tarzana
country: United States
facility: Metabolic Institute of America
state: California
city: West Covina
country: United States
facility: Center for Clinical Trials of San Gabriel
state: California
city: Arvada
country: United States
facility: Western Nephrology & Metabolic
state: Colorado
city: Denver
country: United States
facility: South Denver Nephrology
state: Colorado
city: Golden
country: United States
facility: Colorado Center for Bone Research, P.C.
state: Colorado
city: Boynton Beach
country: United States
facility: Helix Biomedics LLC
state: Florida
city: Boynton Beach
country: United States
facility: Orthopedic Research Institute
state: Florida
city: Bradenton
country: United States
facility: Nova Clinical Research, LLC
state: Florida
city: Brandon
country: United States
facility: PAB Clinical Research
state: Florida
city: Brooksville
country: United States
facility: Meridien Research
state: Florida
city: Chiefland
country: United States
facility: Southeast Clinical Research, LLC
state: Florida
city: Clearwater
country: United States
facility: BayCare Medical Group
state: Florida
city: Delray Beach
country: United States
facility: Cohen Medical Research Associates, LLC
state: Florida
city: Doral
country: United States
facility: Innovation Medical Research Center, Inc
state: Florida
city: Fort Lauderdale
country: United States
facility: Integrative Research Associates
state: Florida
city: Fort Lauderdale
country: United States
facility: Jellinger and Lerman, MD, PA dba The Center for Diabetes and Endocrine Care
state: Florida
city: Hialeah
country: United States
facility: Direct Helpers Medical Center, Inc
state: Florida
city: Hialeah
country: United States
facility: Universal Clinical Research
state: Florida
city: Homestead
country: United States
facility: Homestead Associates in Research
state: Florida
city: Jacksonville
country: United States
facility: St. Vincent's Cardiology
state: Florida
city: Jacksonville
country: United States
facility: Care Partners Clinical Research LLC
state: Florida
city: Lake Clarke Shores
country: United States
facility: Altus Research, Inc.
state: Florida
city: Lakeland
country: United States
facility: Meridien Research
state: Florida
city: Miami Lakes
country: United States
facility: Precision Research Organization
state: Florida
city: Miami
country: United States
facility: Clinical Research of Miami
state: Florida
city: Miami
country: United States
facility: Prestige Clinical Research Center, Inc.
state: Florida
city: Miami
country: United States
facility: Jesscan Medical Research, Internal Medicine
state: Florida
city: Miami
country: United States
facility: Clintex Research Group, Inc. Research
state: Florida
city: Miami
country: United States
facility: University of Miami
state: Florida
city: Miami
country: United States
facility: Florida Medical Center & Research Inc
state: Florida
city: Miami
country: United States
facility: A+ Research Incorporated
state: Florida
city: Miami
country: United States
facility: Unlimited Medical Research, LLC
state: Florida
city: Miami
country: United States
facility: Regenerate Clinical Trials
state: Florida
city: Miami
country: United States
facility: Sanitas Research
state: Florida
city: Miami
country: United States
facility: Future Care Solution, LLC
state: Florida
city: Miami
country: United States
facility: Research Institute of South Florida Inc
state: Florida
city: Miami
country: United States
facility: Tellus Clinical Research, Incorporated
state: Florida
city: Miami
country: United States
facility: New Horizon Research Center
state: Florida
city: Miami
country: United States
facility: Kendall South Medical Center, Inc
state: Florida
city: Miami
country: United States
facility: Coral Research Clinic Corp
state: Florida
city: North Miami Beach
country: United States
facility: School of Clinical Research
state: Florida
city: North Miami Beach
country: United States
facility: Harmony Clinical Research, Incorporated
state: Florida
city: Ocala
country: United States
facility: Magnolia Research Group
state: Florida
city: Orlando
country: United States
facility: Family Medical Center
state: Florida
city: Ormond Beach
country: United States
facility: Peninsula Research, Inc.
state: Florida
city: Plantation
country: United States
facility: Infinity Clinical Research, LLC
state: Florida
city: Saint Petersburg
country: United States
facility: Meridien Research
state: Florida
city: Saint Petersburg
country: United States
facility: Professional Health Care of Pinellas, Inc.
state: Florida
city: Sarasota
country: United States
facility: Intercoastal Medical Group, Endocrinology
state: Florida
city: Tampa
country: United States
facility: Meridien Research
state: Florida
city: West Palm Beach
country: United States
facility: Metabolic Research Institute
state: Florida
city: Atlanta
country: United States
facility: Emory University
state: Georgia
city: Atlanta
country: United States
facility: Laureate Clinical Research Group, LLC
state: Georgia
city: Bainbridge
country: United States
facility: Bainbridge Medical Associates
state: Georgia
city: Cumming
country: United States
facility: Atlanta Heart Specialists, LLC
state: Georgia
city: Decatur
country: United States
facility: McGarity, Jr., William C.
state: Georgia
city: Tucker
country: United States
facility: Atlanta Heart Specialists, LLC
state: Georgia
city: Belleville
country: United States
facility: Belleville Family Medical Associates, Ltd
state: Illinois
city: Chicago
country: United States
facility: Cedar-Crosse Research Center
state: Illinois
city: Chicago
country: United States
facility: Chicago Clinical Research Institute, Inc.
state: Illinois
city: Elgin
country: United States
facility: Associates in Endocrinology, Incorporated
state: Illinois
city: Joliet
country: United States
facility: Kidney Care Center, Nephrology
state: Illinois
city: Avon
country: United States
facility: American Health Network
state: Indiana
city: Franklin
country: United States
facility: American Health Network of Indiana, LLC
state: Indiana
city: Greenfield
country: United States
facility: American Health Network of Indiana, LLC
state: Indiana
city: Muncie
country: United States
facility: American Health Network of Indiana, LLC
state: Indiana
city: Valparaiso
country: United States
facility: Buynak Clinical Research
state: Indiana
city: Waterloo
country: United States
facility: Northeast Iowa Medical Education Foundation
state: Iowa
city: West Des Moines
country: United States
facility: Iowa Diabetes and Endocrinology Research Center
state: Iowa
city: Topeka
country: United States
facility: Cotton-O'Neil Clinical Research Center
state: Kansas
city: Wichita
country: United States
facility: Professional Research Network of Kansas, LLC
state: Kansas
city: Wichita
country: United States
facility: Heartland Research Associates, LLC
state: Kansas
city: Lexington
country: United States
facility: The Research Group of Lexington, LLC
state: Kentucky
city: Metairie
country: United States
facility: Diabetes and Metabolism Associates APMC
state: Louisiana
city: New Orleans
country: United States
facility: Tulane University Hospital and Clinic
state: Louisiana
city: Baltimore
country: United States
facility: Maryland Cardiovascular Specialists
state: Maryland
city: Baltimore
country: United States
facility: Overlea Personal Physicians
state: Maryland
city: Baltimore
country: United States
facility: Johns Hopkins University
state: Maryland
city: Salisbury
country: United States
facility: Delmarva Heart Research Foundation, Inc
state: Maryland
city: Alpena
country: United States
facility: Endeavor Medical Research
state: Michigan
city: Ann Arbor
country: United States
facility: University of Michigan Health System
state: Michigan
city: Flint
country: United States
facility: Aa Mrc Llc
state: Michigan
city: Petoskey
country: United States
facility: McLaren Northern Michigan Hospital
state: Michigan
city: Rochester
country: United States
facility: Remedica LLC
state: Michigan
city: Sterling Heights
country: United States
facility: Tri-County Research, Inc
state: Michigan
city: Troy
country: United States
facility: Oakland Medical Research Center
state: Michigan
city: Saint Paul
country: United States
facility: HealthEast St. Joseph's Hospital
state: Minnesota
city: Carriere
country: United States
facility: Mississippi Medical Research, LLC
state: Mississippi
city: Kansas City
country: United States
facility: Truman Medical Centers, Inc.
state: Missouri
city: Kansas City
country: United States
facility: Kansas City Veterans Administration Medical Center
state: Missouri
city: Kalispell
country: United States
facility: Glacier View Cardiology, PC
state: Montana
city: North Platte
country: United States
facility: Platte River Nephrology
state: Nebraska
city: Omaha
country: United States
facility: Omaha Veterans Affairs Medical Center
state: Nebraska
city: Las Vegas
country: United States
facility: Alas Science Clinical Research
state: Nevada
city: Elizabeth
country: United States
facility: USMA Clin. Research/Union Square Med. Associates
state: New Jersey
city: Linden
country: United States
facility: Mount Sinai - PRIME
state: New Jersey
city: Albuquerque
country: United States
facility: New Mexico Clinical Research and Osteoporosis Center, Inc.
state: New Mexico
city: Bronx
country: United States
facility: Jacobi Medical Center
state: New York
city: Brooklyn
country: United States
facility: Life Medi-Research and Management
state: New York
city: Johnson City
country: United States
facility: United Medical Associates
state: New York
city: Saratoga Springs
country: United States
facility: Saratoga Clinical Research, LLC
state: New York
city: Burlington
country: United States
facility: Kernodle Clinic West
state: North Carolina
city: Calabash
country: United States
facility: Main Street Physicians Care
state: North Carolina
city: Charlotte
country: United States
facility: Box Arthritis & Rheumatology of the Carolinas
state: North Carolina
city: Gastonia
country: United States
facility: Clinical Research of Gastonia
state: North Carolina
city: Greensboro
country: United States
facility: Medication Management, LLC
state: North Carolina
city: Hickory
country: United States
facility: PMG Research of Bristol, LLC
state: North Carolina
city: Monroe
country: United States
facility: Novant Health Southern Piedmont Primary Care
state: North Carolina
city: Mooresville
country: United States
facility: Research Institute of the Carolinas, PLC
state: North Carolina
city: Morehead City
country: United States
facility: Down East Medical Associates
state: North Carolina
city: Morganton
country: United States
facility: Burke Primary Care
state: North Carolina
city: Salisbury
country: United States
facility: PMG Research of Salisbury, LLC
state: North Carolina
city: Wilson
country: United States
facility: Natalie A Doyle, M.D., P.A.
state: North Carolina
city: Akron
country: United States
facility: Summa Health System
state: Ohio
city: Carlisle
country: United States
facility: Medical Frontiers, LLC
state: Ohio
city: Dayton
country: United States
facility: Dayton VA Medical Center
state: Ohio
city: Norton
country: United States
facility: Norton Community Care
state: Ohio
city: Springfield
country: United States
facility: Apex Medical Research, AMR, Incorporated
state: Ohio
city: Toledo
country: United States
facility: ProMedica Health Education & Research Corp.
state: Ohio
city: Oklahoma City
country: United States
facility: COR Clinical Research, LLC
state: Oklahoma
city: Oklahoma City
country: United States
facility: Lynn Health Science Institute
state: Oklahoma
city: Corvallis
country: United States
facility: The Corvallis Clinic, PC
state: Oregon
city: Altoona
country: United States
facility: Blair Medical Associates
state: Pennsylvania
city: Altoona
country: United States
facility: Clinical Research Associates of Central Pennsylvania
state: Pennsylvania
city: Doylestown
country: United States
facility: Central Bucks Cardiology
state: Pennsylvania
city: Doylestown
country: United States
facility: Doylestown Health Cardiology
state: Pennsylvania
city: Jersey Shore
country: United States
facility: Lycoming Internal Medicine, Inc
state: Pennsylvania
city: Smithfield
country: United States
facility: Montgomery Medical Incorporated
state: Pennsylvania
city: Charleston
country: United States
facility: Clinical Trials of South Carolina
state: South Carolina
city: Charleston
country: United States
facility: Medical University of South Carolina
state: South Carolina
city: Gaffney
country: United States
facility: Spectrum Medical Research, LLC
state: South Carolina
city: Greenville
country: United States
facility: VitaLink Research
state: South Carolina
city: Greer
country: United States
facility: Mountain View Clinical Research
state: South Carolina
city: Rock Hill
country: United States
facility: Vita Link Research- Rock Hill
state: South Carolina
city: Rapid City
country: United States
facility: Health Concepts
state: South Dakota
city: Bristol
country: United States
facility: Holston Medical Group
state: Tennessee
city: Johnson City
country: United States
facility: State of Franklin Healthcare Associates, PLLC
state: Tennessee
city: Austin
country: United States
facility: DCT- AACT, LLC dba Discovery Clinical Trials
state: Texas
city: Bedford
country: United States
facility: Rockwood Medical Clinic
state: Texas
city: Dallas
country: United States
facility: Texas Health Physicians Group
state: Texas
city: Dallas
country: United States
facility: Research Institute of Dallas
state: Texas
city: Houston
country: United States
facility: Ben Taub General Hospital
state: Texas
city: Houston
country: United States
facility: Southwest Clinical Trials
state: Texas
city: Houston
country: United States
facility: The Endocrine Center
state: Texas
city: Houston
country: United States
facility: Texas Family Geriatrics Clinic
state: Texas
city: Houston
country: United States
facility: Memorial Clinical Associates Research
state: Texas
city: Irving
country: United States
facility: Break Through Medical Research
state: Texas
city: Irving
country: United States
facility: Medical & Surgical Clinic
state: Texas
city: Katy
country: United States
facility: West Memorial Family Practice
state: Texas
city: New Braunfels
country: United States
facility: Hill Country Medical Associates
state: Texas
city: Odessa
country: United States
facility: Permian Research Foundation
state: Texas
city: Pearland
country: United States
facility: Methodist Hospital Research Institute, Internal Medicine
state: Texas
city: San Antonio
country: United States
facility: Health Texas Research Institute
state: Texas
city: San Antonio
country: United States
facility: Covenant Clinical Research, PA
state: Texas
city: San Antonio
country: United States
facility: DM Clinical Research
state: Texas
city: San Antonio
country: United States
facility: DCT-Stone Oak, LLC dba Discovery Clinical Trials
state: Texas
city: Sealy
country: United States
facility: Sealy Urgent Care Center and Medical Clinic
state: Texas
city: Sugar Land
country: United States
facility: Pioneer Research Solutions, Inc.
state: Texas
city: Tomball
country: United States
facility: DM Clinical Research
state: Texas
city: Victoria
country: United States
facility: Crossroads Clinical Research, LLC
state: Texas
city: Clinton
country: United States
facility: Ericksen Research & Development, LLC
state: Utah
city: Draper
country: United States
facility: Focus Clinical Research
state: Utah
city: Ogden
country: United States
facility: Advanced Research Institute
state: Utah
city: Ogden
country: United States
facility: Paramount Medical Care
state: Utah
city: Burke
country: United States
facility: Burke Internal Medicine and Research
state: Virginia
city: Herndon
country: United States
facility: Nova Health Management & Research Group, PC
state: Virginia
city: Manassas
country: United States
facility: Manassas Clinical Research Center
state: Virginia
city: Richmond
country: United States
facility: Dominion Medical Associates, Inc.
state: Virginia
city: Richmond
country: United States
facility: Hunter Holmes McGuire Veterans Administration Medical Center
state: Virginia
city: Roanoke
country: United States
facility: Roanoke Heart Institute PLC
state: Virginia
city: Salem
country: United States
facility: Salem Veterans Affairs Medical Center
state: Virginia
city: Port Orchard
country: United States
facility: Sound Medical Research
state: Washington
city: Milwaukee
country: United States
facility: Zablocki VA Medical Center
state: Wisconsin
city: Adrogue
country: Argentina
facility: Instituto Médico Adrogué
city: Bahia Blanca
country: Argentina
facility: Hospital Interzonal General de Agudos Dr Jose Penna
city: Bahia Blanca
country: Argentina
facility: Inst de Inv Clinicas-Bahia Blanca
city: Bahia Blanca
country: Argentina
facility: Hospital Italiano Regional del Sur, Bahia Blanca
city: Caba
country: Argentina
facility: Hospital Sirio-Libanés
city: Ciudad Autonoma Buenos Aires
country: Argentina
facility: Centro de Investigaciones Metabólicas
city: Ciudad Autonoma Buenos Aires
country: Argentina
facility: CIPREC
city: Ciudad Autonoma Buenos Aires
country: Argentina
facility: Hospital Italiano
city: Ciudad Autonoma Buenos Aires
country: Argentina
facility: Consultorios Asociados de Endocrinología e Invest Clínica
city: Ciudad Autonoma Buenos Aires
country: Argentina
facility: CEDIC - Centro de Investigacion Clinica
city: Ciudad Autonoma Buenos Aires
country: Argentina
facility: Instituto Cardiovascular de Buenos Aires
city: Ciudad Autonoma Buenos Aires
country: Argentina
facility: CCBR - Buenos Aires - AR
city: Ciudad Autonoma de Bs As
country: Argentina
facility: Centro Médico Viamonte
city: Cordoba
country: Argentina
facility: Centro Médico Colon
city: Cordoba
country: Argentina
facility: CEMAIC - Centro Medico Especializado
city: Cordoba
country: Argentina
facility: Inst. Privado de Inv. Clínicas de Córdoba
city: Cordoba
country: Argentina
facility: Clínica Colombo
city: Cordoba
country: Argentina
facility: Instituto DAMIC - Fundacion Rusculleda
city: Cordoba
country: Argentina
facility: Hospital Cordoba
city: Cordoba
country: Argentina
facility: IPAC - Clínica Privada Caraffa SRL
city: Cordoba
country: Argentina
facility: Clinica Privada del Prado
city: Corrientes
country: Argentina
facility: Centro Universitario de Investigacion Corrientes
city: Córdoba
country: Argentina
facility: Sanatorio Allende S.A.
city: Godoy Cruz
country: Argentina
facility: CIPADI
city: Haedo
country: Argentina
facility: Centro Medico Dr. Javier Marino
city: La Plata
country: Argentina
facility: Hospital Italiano de La Plata
city: Mar del Plata
country: Argentina
facility: Unidad de Cardiologia Clinica
city: Mar del Plata
country: Argentina
facility: Hospital Privado de Comunidad
city: Mendoza
country: Argentina
facility: Hospital Central de Mendoza, Mendoza
city: Parana
country: Argentina
facility: Hospital San Martin
city: Pellegrini 661
country: Argentina
facility: Sanatorio San Martin S.A., Venado Tuerto
city: Quilmes
country: Argentina
facility: CER Instituto Médico
city: Quilmes
country: Argentina
facility: Instituto de Investigaciones Clínicas de Quilmes
city: Rosario
country: Argentina
facility: Instituto de Investigaciones Clinicas de Rosario
city: Rosario
country: Argentina
facility: Instituto Medico de la Fundacion Estudios Clinicos, Rosario
city: Rosario
country: Argentina
facility: Instituto Medico Fundación Grupo Colaborativo Rosario
city: Rosario
country: Argentina
facility: Sanatorio Británico
city: Rosario
country: Argentina
facility: Sanatorio Norte
city: Rosario
country: Argentina
facility: Instituto de Hematologia y Medicina Clinica Ruben Davoli
city: Rosario
country: Argentina
facility: Sanatorio Delta
city: Rosario
country: Argentina
facility: Centro Medico CIR
city: Rosario
country: Argentina
facility: CEDyN
city: Rosario
country: Argentina
facility: Instituto CAICI
city: Rosario
country: Argentina
facility: Instituto Medico CENICLAR-C de Investigaciones Clinicas
city: Salta
country: Argentina
facility: Centro Cardiovascular Salta
city: Salta
country: Argentina
facility: CORDIS S.A., Salta
city: Salta
country: Argentina
facility: Prevencion Cardiovascular Salta, Salta
city: San Miguel de Tucuman
country: Argentina
facility: CCBR Tucuman
city: San Miguel de Tucumán
country: Argentina
facility: Investigaciones Clinicas Tucuman
city: San Nicolas
country: Argentina
facility: Instituto de Investigaciones Clinicas San Nicolas
city: San Vicente
country: Argentina
facility: Centro Medico Luquez
city: Santa Fe
country: Argentina
facility: Centro de Investigaciones Clínicas del Litoral
city: Santa Fé
country: Argentina
facility: Hospital "Dr. José Maria Cullen "
city: Villa Maria
country: Argentina
facility: Clinica Privada Fusavim SRL
city: Zarate
country: Argentina
facility: Instituto de Investigaciones Clínicas Zárate
city: Belo Horizonte
country: Brazil
facility: Hospital Felício Rocho
city: Belo Horizonte
country: Brazil
facility: Hospital Lifecenter
city: Belo Horizonte
country: Brazil
facility: Hospital Vera Cruz
city: Belém
country: Brazil
facility: Hospital Universitário João de Barros Barreto
city: Campina Grande do Sul
country: Brazil
facility: Hospital Angelina Caron
city: Campinas
country: Brazil
facility: HMCP - Hospital e Maternidade Celso Pierro - PUC-Campinas
city: Campinas
country: Brazil
facility: CAEP - Centro Avançado de Estudos e Pesquisas Ltda.,Campinas
city: Canoas
country: Brazil
facility: Hospital Universitário
city: Caxias do Sul
country: Brazil
facility: Universidade de Caxias do Sul - IPCEM - Inst. de Pesq.clilni
city: Curitiba
country: Brazil
facility: Hospital de Caridade Santa Casa de Misericordia de Curitiba
city: Curitiba
country: Brazil
facility: HC UFPR
city: Curitiba
country: Brazil
facility: Cruz Vermelha Brasileira - Filial do Estado do Paraná
city: Fortaleza
country: Brazil
facility: Centro de Estudos em Diabetes e Hipertensão
city: Fortaleza
country: Brazil
facility: Centro de Pesquisas em Diabetes e Doenças
city: Fortaleza
country: Brazil
facility: ICE-HUWC - Instituto Cearense de Endocrinologia
city: Goiania
country: Brazil
facility: Via Médica
city: Lajeado
country: Brazil
facility: Hospital Bruno Born
city: Marília
country: Brazil
facility: ICM - Instituto do Coração de Marília
city: Passo Fundo
country: Brazil
facility: Hospital São Vicente de Paulo
city: Porto Alegre
country: Brazil
facility: Irmandade da Santa Casa de Misericórdia de Porto Alegre
city: Porto Alegre
country: Brazil
facility: Centro de Pesquisas em Diabetes
city: Porto Alegre
country: Brazil
facility: Instituto de Cardiologia Rio Grande do Sul
city: Recife
country: Brazil
facility: Centro de Pesquisas Médicas Básica e Clínica Ltda
city: Rio de Janeiro
country: Brazil
facility: CCBR - Rio de Janeiro - BR
city: Santa Maria
country: Brazil
facility: Centro de Pesquisa Clínica Santa Maria
city: Santo Andre
country: Brazil
facility: CCBR Brasil - São Paulo
city: Sao Jose do Rio Preto
country: Brazil
facility: Instituto Domingo Braile
city: Sao Jose do Rio Preto
country: Brazil
facility: Fundacao Faculdade Regional de Medicina, Sao Jose
city: Sao Paulo
country: Brazil
facility: Centro de Pesquisa Clinica - CPCLIN
city: Sao Paulo
country: Brazil
facility: FGM Clínica Paulista de Doenças Cardiovasculares LTDA
city: Sao Paulo
country: Brazil
facility: Hospital Sao Paulo - UNIFESP
city: São Paulo
country: Brazil
facility: Cpquali Pesquisa Clinica Ltda
city: São Paulo
country: Brazil
facility: Hospital Alemao Oswaldo Cruz
city: São Paulo
country: Brazil
facility: Hospital do Servidor Público Estadual
city: São Paulo
country: Brazil
facility: Dr. Consulta
city: São Paulo
country: Brazil
facility: Hospital das Clinicas da FMUSP
city: São Paulo
country: Brazil
facility: Incor - Instituto do Coração - HCFMUSP
city: Tatui
country: Brazil
facility: IMC - Instituto de Moléstias Cardiovasculares Tatuí
city: Uberlândia
country: Brazil
facility: ICT - Instituto do Coração do Triângulo
city: Blagoevgrad
country: Bulgaria
facility: MHAT - Blagoevgrad, EOOD
city: Byala
country: Bulgaria
facility: MHAT "Yuliya Vrevska" EOOD, Byala
city: Kazanlak
country: Bulgaria
facility: MHAT "Dr.Stambolski", Cardiology&Intensiv Care Dept,Kazanlak
city: Plovdiv
country: Bulgaria
facility: UMHAT "Kaspela", EOOD, Plovdiv
city: Ruse
country: Bulgaria
facility: DCC 1 - Ruse, EOOD
city: Sofia
country: Bulgaria
facility: Fifth MHAT - Sofia EAD, Sofia
city: Sofia
country: Bulgaria
facility: MHAT Lyulin
city: Sofia
country: Bulgaria
facility: MHAT 'Tokuda Hospital Sofia', EAD
city: Sofia
country: Bulgaria
facility: USHATE Hospital 'Academy Ivan Penchev', Sofia
city: Varna
country: Bulgaria
facility: DCC "Equita" EOOD
city: Edmonton
country: Canada
facility: ALTA Clinical Research Inc.
state: Alberta
city: Red Deer
country: Canada
facility: The Bailey Clinic
state: Alberta
city: Burnaby
country: Canada
facility: Dr. Ronald Collette
state: British Columbia
city: Penticton
country: Canada
facility: The Medical Arts Health Research Group
state: British Columbia
city: Vancouver
country: Canada
facility: LMC Clinical Research dba Manna Research Inc. Vancouver
state: British Columbia
city: Victoria
country: Canada
facility: Fraser Clinical Trials Inc.
state: British Columbia
city: Victoria
country: Canada
facility: Discovery Clinical Services Ltd.
state: British Columbia
city: Victoria
country: Canada
facility: CookMed Research
state: British Columbia
city: Winnipeg
country: Canada
facility: Winnipeg Regional Health Authority, Winnipeg
state: Manitoba
city: Halifax
country: Canada
facility: True North Clinical Research Halifax, Inc.
state: Nova Scotia
city: Barrie
country: Canada
facility: LMC Endocrinology Centres (Barrie) Ltd.
state: Ontario
city: Burlington
country: Canada
facility: JBN Medical Diagnostic Services Inc.
state: Ontario
city: Etobicoke
country: Canada
facility: LMC Endocrinology Centres (Etobicoke) Ltd.
state: Ontario
city: Markham
country: Canada
facility: LMC Endocrinology Centres (Markham) Ltd.
state: Ontario
city: Newmarket
country: Canada
facility: SKDS Research Incorporated
state: Ontario
city: Sudbury
country: Canada
facility: Medicor Research
state: Ontario
city: Sudbury
country: Canada
facility: Sudbury Cardiac Research
state: Ontario
city: Sudbury
country: Canada
facility: Dr. R. Labonte Prof. Med. Corp
state: Ontario
city: Brossard
country: Canada
facility: ViaCar Recherche Clinique Inc
state: Quebec
city: Greenfield Park
country: Canada
facility: Hopital Charles - LeMoyne
state: Quebec
city: Laval
country: Canada
facility: Centre De Recherche Clinique
state: Quebec
city: Longueuil
country: Canada
facility: Recherche Invascor Inc.
state: Quebec
city: Montreal
country: Canada
facility: Centre Hospitalier de l'Universite de Montreal (CHUM)
state: Quebec
city: Montreal
country: Canada
facility: McGill University Health Centre (MUHC)
state: Quebec
city: St-Jerome
country: Canada
facility: St Jerome Medical Research Inc.
state: Quebec
city: Ville Saint-Laurent
country: Canada
facility: LMC Endocrinology Centres (Montreal)
state: Quebec
city: Quebec
country: Canada
facility: Recherche Clinique Sigma Inc.
city: Quebec
country: Canada
facility: Clinique des maladies Lipidiques de Quebec
city: Punta Arenas
country: Chile
facility: Hospital Regional de Punta Arenas Dr. Lautaro Navarro Avaria
city: Santiago
country: Chile
facility: Hospital El Pino
city: Santiago
country: Chile
facility: Sociedad Medica Cardiologica El Llano
city: Santiago
country: Chile
facility: Hospital Militar de Santiago
city: Santiago
country: Chile
facility: Hospital Sotero del Rio
city: Santiago
country: Chile
facility: CeCim - Centro de Estudios Clinicos e Investigacion Medica
city: Santiago
country: Chile
facility: Hospital Padre Alberto Hurtado
city: Valdivia
country: Chile
facility: Hospital Base Valdivia
city: Viña del Mar
country: Chile
facility: Hospital Naval Almirante Nef
city: Beijing
country: China
facility: Beijing Jishuitan Hospital
city: Guangzhou
country: China
facility: Third Affiliated Hospital of Guangzhou Medical University
city: Hangzhou
country: China
facility: Zhejiang University School of Medicine SIR RUN RUN SHAW Hospital
city: Jinan
country: China
facility: Center Hospital of Jinan
city: Nanning
country: China
facility: People's Hospital of Guangxi Zhuang Autonomous Region
city: Shanghai
country: China
facility: Tongji Hospital, Tongji University
city: Xi'an
country: China
facility: First Affiliated Hospital of Xi'an JiaoTong University
city: Yinchuan
country: China
facility: General Hospital of Ningxia Medical University
city: Armenia
country: Colombia
facility: CEQUIN
city: Barranquilla
country: Colombia
facility: Corazon IPS S.A.S.
city: Barranquilla
country: Colombia
facility: Clínica de la Costa Ltda.
city: Barranquilla
country: Colombia
facility: IPS Centro Cientifico Asistencia
city: Bogota
country: Colombia
facility: Centro de Atencion e Investigacion Medica S.A. - CAIMED
city: Bogota
country: Colombia
facility: CAFESALUD Medicina Prepagada S.A.
city: Bogota
country: Colombia
facility: Solano y Terront Servicios Médicos Ltda.
city: Bogotá
country: Colombia
facility: Dexa Diabetes Servicios Médicos Ltda
city: Cali
country: Colombia
facility: Fundacion Reina Isabel
city: Cali
country: Colombia
facility: IPS Centro Medico Julián Coronel S.A.
city: Espinal
country: Colombia
facility: Fundación Centro de Investigaciones Biomédicas Riescard
city: Medellin
country: Colombia
facility: Centro de Investigacion Clínica Avanzada
city: Medellin
country: Colombia
facility: Fundacion Centro de Investigacion Clinica CIC, Medellin
city: Pasto
country: Colombia
facility: Fundacion Centro de Obesidad y Metabolismo - COMETA
city: Zipaquirá
country: Colombia
facility: Healthy Medical CenterS.A.S, Zipaquirá
city: Karlovac
country: Croatia
facility: General Hospital Karlovac
city: Krapinske Toplice
country: Croatia
facility: Hospital for Medical Rehabilitation, Krapinske Toplice
city: Slavonski Brod
country: Croatia
facility: General Hospital Slavonski Brod
city: Varazdin
country: Croatia
facility: General Hospital Varazdin
city: Zadar
country: Croatia
facility: General Hosp. Zadar, Dept. of Internal Medicine-Pulmonology
city: Zagreb
country: Croatia
facility: Clinical Hospital Sveti Duh
city: Zagreb
country: Croatia
facility: University hospital center Zagreb
city: Brno
country: Czechia
facility: Fakultni nemocnice u sv. Anny v Brne
city: Brno
country: Czechia
facility: Fakultni nemocnice u sv. Anny v Brne
city: Bruntal
country: Czechia
facility: Revmatologie Bruntal, s.r.o.
city: Chocen
country: Czechia
facility: Poliklinika Chocen, a.s.
city: Dolni Brezany
country: Czechia
facility: Aesculap Ambulance Sro
city: Hodonin
country: Czechia
facility: OKELI s.r.o.
city: Jindrichuv Hradec
country: Czechia
facility: Nemocnice Jindrichuv Hradec a.s.
city: Liberec
country: Czechia
facility: Regional Hospital Liberec
city: Marianske Lazne
country: Czechia
facility: InterKardioML s.r.o.
city: Nachod
country: Czechia
facility: Interna a diabetologicka ordinace s.r.o.
city: Olomouc
country: Czechia
facility: PreventaMed, s.r.o.
city: Praha 10
country: Czechia
facility: Univ. Hospital Kralovske Vinohrady
city: Praha 2
country: Czechia
facility: Vseobecna fakultni nemocnice V Praze
city: Praha 4 - Krc
country: Czechia
facility: Thomayer Hospital
city: Praha 8
country: Czechia
facility: ResTrial s.r.o.
city: Slany
country: Czechia
facility: Hospital Slany, Internal Department
city: Teplice
country: Czechia
facility: Krajska zdravotni, a.s. - Nemocnice Teplice, o.z.
city: Aschaffenburg
country: Germany
facility: Studienzentrum Aschaffenburg
city: Bad Homburg
country: Germany
facility: Zentrum für klinische Forschung Dr. med. Irma Schöll & Kollegen
city: Dresden
country: Germany
facility: Universitätsklinikum Carl Gustav Carus Dresden
city: Frankfurt am Main
country: Germany
facility: IKF Pneumologie GmbH & Co. KG
city: Frankfurt
country: Germany
facility: ClinPhenomics GmbH & Co KG, Frankfurt
city: Hohenmölsen
country: Germany
facility: Diabetologische Schwerpunktpraxis, Hohenmölsen
city: Leipzig
country: Germany
facility: EUGASTRO GmbH, Leipzig
city: Leipzig
country: Germany
facility: Gemeinschaftspraxis Dr. Taeschner / Dr. Bonigut, Leipzig
city: Baja
country: Hungary
facility: Lausmed Kft. Outpatient Unit of Internal Medicine
city: Balassagyarmat
country: Hungary
facility: Dr. Kenessey Albert Kórház-Rendelõintézet, Balassagyarmat
city: Balatonfured
country: Hungary
facility: DRC Gyogyszervizsgalo Kozpont Kft., Balatonfured
city: Budapest
country: Hungary
facility: Clinexpert Kft.
city: Budapest
country: Hungary
facility: Obudai Egeszsegugyi Centrum
city: Budapest
country: Hungary
facility: QUALICLINIC Kft
city: Budapest
country: Hungary
facility: Semmelweis Egyetem, Budapest
city: Budapest
country: Hungary
facility: Semmelweis Egyetem, Budapest
city: Budapest
country: Hungary
facility: Semmelweis Egyetem, Budapest
city: Debrecen
country: Hungary
facility: University Debrecen Hospital
city: Eger
country: Hungary
facility: Markhot Ferenc Hospital, Eger
city: Hodmezovasarhely
country: Hungary
facility: Csongrad Megyei Eu. Ellato Kozp. Hodmezovasarhely-Mako
city: Kaposvar
country: Hungary
facility: Somogy Megyei Kaposi Mor Oktato Korhaz, Kaposvar
city: Komarom
country: Hungary
facility: Selye Janos Hospital Komarom
city: Letavertes
country: Hungary
facility: Ermellek Egeszsegcentrum
city: Miskolc
country: Hungary
facility: Borsod-Abauj-Zemplen Megyei Korhaz es Egyetemi Oktato Korhaz
city: Pecs
country: Hungary
facility: Pecsi Tudomanyegyetem
city: Szeged
country: Hungary
facility: Szegedi Tudomanyegyetem Szent-Gyorgyi Albert Klin. Kozpont
city: Zalaegerszeg
country: Hungary
facility: Zala Megyei Szent Rafael Korhaz
city: Afula
country: Israel
facility: Haemek Medical Center
city: Haifa
country: Israel
facility: Bnei Zion Medical Center, Haifa
city: Haifa
country: Israel
facility: Rambam Medical Center
city: Herzliya
country: Israel
facility: Herzliya Medical Center
city: Holon
country: Israel
facility: Wolfson Medical Center
city: Jerusalem
country: Israel
facility: Hadassah Medical Center, Ein-Karem
city: Kfar-Saba
country: Israel
facility: Meir Medical Center
city: Nahariya
country: Israel
facility: Galilee Medical Center
city: Safed
country: Israel
facility: Ziv Medical Center
city: Tel Aviv
country: Israel
facility: Sourasky Medical Center
city: Aichi, Nagoya
country: Japan
facility: Daishinkai Medical Corporation Ookuma Hospital
city: Chiba, Matsudo
country: Japan
facility: Seikeikai New Tokyo Heart Clinic
city: Ehime, Matsuyama
country: Japan
facility: Saiseikai Matsuyama Hospital
city: Fukuoka, Iizuka
country: Japan
facility: Aso Co.,Ltd Iizuka Hospital
city: Fukuoka, Kitakyushu
country: Japan
facility: Kitakyushubyoin Kitakyushu General Hospital
city: Hyogo, Kawanishi
country: Japan
facility: The Veritas Hospital
city: Ibaraki, Sashima-gun
country: Japan
facility: Ibaraki Seinan Medical Center Hospital
city: Kanagawa, Kawasaki
country: Japan
facility: Kokan Clinic
city: Nagano, Nagano
country: Japan
facility: Nagano Red Cross Hospital
city: Takamatsu-shi
country: Japan
facility: Josuikai Olive Takamatsu Medical Clinic
city: Anyang-si
country: Korea, Republic of
facility: Hallym University Sacred Heart Hospital
city: Busan
country: Korea, Republic of
facility: Inje University Busan Paik Hospital
city: Busan
country: Korea, Republic of
facility: Dong-A University Hospital
city: Busan
country: Korea, Republic of
facility: Pusan National Univ. Hosp
city: Goyang-si
country: Korea, Republic of
facility: Myongji Hospital
city: Incheon
country: Korea, Republic of
facility: Gachon University Gil Medical Center
city: Seoul
country: Korea, Republic of
facility: The Catholic University of Korea, Seoul St.Mary's Hospital
city: Seoul
country: Korea, Republic of
facility: Seoul National University Hospital
city: Seoul
country: Korea, Republic of
facility: Asan Medical Center
city: Seoul
country: Korea, Republic of
facility: Korea University Anam Hospital
city: Seoul
country: Korea, Republic of
facility: Korea University Guro Hospital
city: Wonju
country: Korea, Republic of
facility: Wonju Severance Christian Hosp
city: Alor Setar
country: Malaysia
facility: Hospital Sultanah Bahiyah
city: Klang
country: Malaysia
facility: Hospital Tengku Ampuan Rahimah
city: Kuala Lumpur
country: Malaysia
facility: University Malaya Medical Centre
city: Kuantan
country: Malaysia
facility: Hospital Tengku Ampuan Afzan
city: Petaling Jaya
country: Malaysia
facility: Monash University(Sunway Campus)
city: Pulau Pinang
country: Malaysia
facility: Hospital Pulau Pinang
city: Serdang
country: Malaysia
facility: Universiti Putra Malaysia
city: Seri Manjung
country: Malaysia
facility: Hospital Seri Manjung
city: Taiping
country: Malaysia
facility: Hospital Taiping
city: Tampin
country: Malaysia
facility: Klinik Kesihatan Tampin
city: Chihuahua
country: Mexico
facility: Investigación en Salud y Metabolismo S.C.
city: Cuautitlan Izcalli
country: Mexico
facility: Phylasis Clinicas Research S de RL de CV
city: Culiacan
country: Mexico
facility: Centro para el Desarrollo de la Medicina y de Asist Med Espe
city: Distrito Federal
country: Mexico
facility: Centro de Investigacion Biomedica y Farmaceutica, S.C.
city: Guadalajara
country: Mexico
facility: Servicios Medicos de la Pena SC
city: Merida
country: Mexico
facility: Medical Care & Research SA de CV
city: Merida
country: Mexico
facility: Sociedad de Cirugia Vascular Plastica Reconstructiva
city: Mexico
country: Mexico
facility: Phytomedicamenta S.A. de C.V.
city: Mexico
country: Mexico
facility: Comite Mexicano Para la Prevencion de Osteoporosis AC
city: Mexico
country: Mexico
facility: Centro de Atención e Investigación en Factores de Riesgo
city: Mexico
country: Mexico
facility: Clinstile S.A. de C.V.
city: Mexico
country: Mexico
facility: Ultimate Medica SA de CV
city: Mexico
country: Mexico
facility: Health Pharma Professional Research S.A. de C.V.
city: Monterrey
country: Mexico
facility: Centro de Estudios Clinicos y Especialidades Medicas, S.C.
city: Monterrey
country: Mexico
facility: AVIX Investigación Clínica S.C
city: Monterrey
country: Mexico
facility: Global Trial Research Center S.A. de C.V.
city: Morelia
country: Mexico
facility: Centro de Investigacion Clinica Chapultepec S. A. de C. V.
city: Queretaro
country: Mexico
facility: Centro de Estudios Clínicos de Queretaro S.C., CECLIQ
city: Tijuana
country: Mexico
facility: Centro de Investigacion Cardiovascular y Metabolica
city: Zapopan
country: Mexico
facility: Centro de Investigación Médica de Ocidente, S.C.
city: Zapopan
country: Mexico
facility: Hospital Dr Angel Leano
city: Arnhem
country: Netherlands
facility: Rijnstate Hospital
city: Dordrecht
country: Netherlands
facility: Albert SchweitzerZiekenhuis
city: Groningen
country: Netherlands
facility: Universitair Medisch Centrum Groningen
city: Groningen
country: Netherlands
facility: Martini Ziekenhuis
city: Hoogeveen
country: Netherlands
facility: Bethesda Cardiology Group, Hoogeveen
city: Maastricht
country: Netherlands
facility: Maastricht Universitair Medisch Centrum
city: Rotterdam
country: Netherlands
facility: Rotterdam Research Institute
city: Utrecht
country: Netherlands
facility: Universitair Medisch Centrum Utrecht
city: Waalwijk
country: Netherlands
facility: TweeSteden Ziekenhuis
city: Zutphen
country: Netherlands
facility: Gelre Ziekenhuis Zutphen
city: Chorzow
country: Poland
facility: B_Serwis Popenda Sp.Jawna
city: Gdansk
country: Poland
facility: Poradnia Kardiologiczna Jaroslaw Jurowiecki
city: Gdansk
country: Poland
facility: University Clinical Center, Gdansk
city: Gdynia
country: Poland
facility: Indywidualna Specjalistyczna Praktyka Lekarska
city: Grodzisk Mazowiecki
country: Poland
facility: MCBK Iwona Czajkowska Anna Podrazka- Szczepaniak S.C.
city: Katowice
country: Poland
facility: Centrum Medyczne Pratia Katowice II
city: Kielce
country: Poland
facility: Polimedica Centrum Bada?, Profilaktyki I Leczenia
city: Krakow
country: Poland
facility: NZOZ Centrum Medyczne ProMiMed Sp. z o.o., Sp.k., Krakow
city: Lodz
country: Poland
facility: Centrum Terapii Wspolczesnej J.M.
city: Lodz
country: Poland
facility: CCBR - Lodz - PL, Lodz
city: Lodz
country: Poland
facility: Individual Specialized Practice
city: Lublin
country: Poland
facility: Centrum Medyczne "Luxmed" Sp. z o.o.
city: Lublin
country: Poland
facility: KO-MED Centra Kliniczne Lublin II
city: Lublin
country: Poland
facility: NZOZ Specialized Ambulance "MEDICA"
city: Nowy Duninow
country: Poland
facility: RCMed- Regionalne Centrum Medyczne
city: Oswiecim
country: Poland
facility: Medicome Sp. z o.o.
city: Parczew
country: Poland
facility: Prywatny Gabinet Lekarski Lech Lazuka
city: Poznan
country: Poland
facility: Clin.Hosp.Med.Univ.Marcinkowski in Poznan
city: Poznan
country: Poland
facility: Praktyka Lekarska Ewa Krzyzagorska
city: Pulawy
country: Poland
facility: KOMED Marek Konieczny
city: Ruda Slaska
country: Poland
facility: Indywidualna Specjalistyczna Praktyka Lekarska Dr N Med Andrzej Wittek
city: Rzeszow
country: Poland
facility: Centrum Medyczne Medyk
city: Sochaczew
country: Poland
facility: RCMed- Regionalne Centrum Medyczne
city: Sroda Wielkopolska
country: Poland
facility: NSZOZ Medicus
city: Staszow
country: Poland
facility: KO-MED Centra Kliniczne Staszow
city: Torun
country: Poland
facility: Lecznice Citomed Sp. z o.o.
city: Torun
country: Poland
facility: NZOZ Nasz Lekarz
city: Warsaw
country: Poland
facility: NBR Polska
city: Warszaw
country: Poland
facility: CCBR/Somed - Warszaw - PL
city: Wroclaw
country: Poland
facility: Regionalna Poradnia Diabetoloiczna Zytkiewicz-Jaruga
city: Zamosc
country: Poland
facility: KO-MED Centra Kliniczne Zamosc
city: Zgierz
country: Poland
facility: Polimedica Centrum Bada?, Profilaktyki I Leczenia
city: Braga
country: Portugal
facility: Hospital de Braga-Escala Braga
city: Coimbra
country: Portugal
facility: CHUC - Centro Hospitalar e Universitário de Coimbra, EPE
city: Lisboa
country: Portugal
facility: APDP - Associação Protectora dos Diabéticos de Portugal
city: Lisboa
country: Portugal
facility: CHLO, EPE - Hospital S. Francisco Xavier
city: Lisboa
country: Portugal
facility: Hospital da Luz
city: Porto
country: Portugal
facility: Hospital CUF Porto
city: V. N. Gaia
country: Portugal
facility: Centro Hospitalar de Vila Nova de Gaia
city: Alba Iulia
country: Romania
facility: SC Diana Barbonta SRL, Alba Iulia
city: Bucuresti
country: Romania
facility: Spitalul Universitar de Urgenta, Bucuresti
city: Bucuresti
country: Romania
facility: I.N.D.N.B.M. "Prof. Dr. N.C. Paulescu" - Sediul Central
city: Bucuresti
country: Romania
facility: I.N.D.N.B.M. "Prof. Dr. N.C. Paulescu" - Sediul Central
city: Bucuresti
country: Romania
facility: CMI Dr. Stolea T. Violeta
city: Bucuresti
country: Romania
facility: Clinica Medicala Data Plus SRL
city: Bucuresti
country: Romania
facility: I.N.D.N.B.M. "Prof. Dr. N.C. Paulescu" - Sediul "I.L. Caragiale"
city: Bucuresti
country: Romania
facility: S.C Centrul Medical "Sanatatea Ta" S.R.L
city: Bucuresti
country: Romania
facility: S.C. Policlinica CCBR SRL, Bucuresti
city: Buzau
country: Romania
facility: Medcon SRL
city: Galati
country: Romania
facility: Spitalul Clinic Judetean de Urgenta ¿Sf. Apostol Andrei¿
city: Iasi
country: Romania
facility: Spitalul Clinic, Iasi
city: Iasi
country: Romania
facility: Consultmed SRL, Iasi
city: Iasi
country: Romania
facility: SC Diaconu-Sotropa Michaela, Cabinet de Diabet
city: Oradea
country: Romania
facility: S.C Grandmed S.R.L, Oradea
city: Oradea
country: Romania
facility: Pelican Impex SRL, Cabinet Nr. 15
city: Oradea
country: Romania
facility: S.C Anamed S.R.L
city: Ploiesti
country: Romania
facility: S.C. Diabmed Dr. Popescu Alexandrina S.R.L
city: Sibiu
country: Romania
facility: Gensan SRL
city: Timisoara
country: Romania
facility: Centrul Medical Dr Negrisanu SRL
city: Tirgu Mures
country: Romania
facility: Mediab SRL
city: Barnaul
country: Russian Federation
facility: SBEI HPE Altay State Medical University of MoH and SD
city: Kemerovo
country: Russian Federation
facility: Res.Inst.-Compl.Iss.Cardi.Dis.
city: Kemerovo
country: Russian Federation
facility: NSIH "Departmental Hospital on Station Kemerovo of OJSC "Russian Railways"
city: Moscow
country: Russian Federation
facility: First Moscow State Medical University n.a. I.M. Sechenov
city: Moscow
country: Russian Federation
facility: Moscow 1st State Med.Univ.n.a.I.M.Sechenov
city: Moscow
country: Russian Federation
facility: SBEI HPE "Moscow State Medical and Dentistry University
city: Moscow
country: Russian Federation
facility: Moscow State Medical Dentistry University
city: Novosibirsk
country: Russian Federation
facility: SBIH of Novosibirsk Region "Clinical Emergency Hospital #2"
city: Novosibirsk
country: Russian Federation
facility: Novosibirsk Regional Clinical Cardiological Dispansary
city: Novosibirsk
country: Russian Federation
facility: FSBSI "Scientific Research Institute", Novosibirsk
city: Novosibirsk
country: Russian Federation
facility: FSBSI "Scientific and Research Institute of Physiology and Basic Medicine"
city: Omsk
country: Russian Federation
facility: BIH of OR "City Hospital # 2", Omsk
city: Perm
country: Russian Federation
facility: SBIH of Perm territory " City Clinical Hospital # 2 n.a.
city: Ryazan
country: Russian Federation
facility: SBI of Ryazan region "Regional Clinical Cardiological Dis.
city: Saint-Petersburg
country: Russian Federation
facility: FSBMEI HPE "Military Medical Academy n.a. S.M. Kirov"
city: Saint-Petersburg
country: Russian Federation
facility: 1stPavlov St.Med.Univ.St.-Petersburg Res.Inst.
city: Saint-Petersburg
country: Russian Federation
facility: Federal North-West Medical Research Centre
city: Saint-Petersburg
country: Russian Federation
facility: SPb SBHI "City Policlinic #74"
city: Saint-Petersburg
country: Russian Federation
facility: SPb SBIH "City Pokrovskaya Hospital"
city: Sestroretsk
country: Russian Federation
facility: GUZ "City Clinical Hospital #40, 197706 Saint-Petersburg
city: St. Petersburg
country: Russian Federation
facility: Medical Research Institute LLC, St. Petersburg
city: Tomsk
country: Russian Federation
facility: FSBI "Research Institute for Cardiology"
city: Alberton
country: South Africa
facility: Cardiology Clinical Research
city: Bloemfontein
country: South Africa
facility: Iatros International
city: Bloemfontein
country: South Africa
facility: Limaro Research
city: Cape Town
country: South Africa
facility: Dr JM Engelbrecht Practice
city: Cape Town
country: South Africa
facility: Dr Dawood, Mohamed and Pillay
city: Cape Town
country: South Africa
facility: TREAD Research
city: Cape Town
country: South Africa
facility: Langeberg Clinical Trials
city: Cape Town
country: South Africa
facility: Cape Town Medical Research Centre
city: Cape Town
country: South Africa
facility: Ismail, SM
city: Cape Town
country: South Africa
facility: Groote Schuur Hospital
city: Durban
country: South Africa
facility: Latiff, GHVM
city: Durban
country: South Africa
facility: Londisizwe Research Centre, Durban
city: Johannesburg
country: South Africa
facility: Diabetes Care Centre
city: Johannesburg
country: South Africa
facility: Wits Clinical Research Chris Hani Baragwanath Hospital
city: Johannesburg
country: South Africa
facility: WCR CMJAH Clinical Trial Site
city: Krugersdorp
country: South Africa
facility: DJW Navorsing
city: Pretoria
country: South Africa
facility: Emmed Research
city: Pretoria
country: South Africa
facility: University of Pretoria
city: Pretoria
country: South Africa
facility: Syzygy Clinical Research Services
city: Pretoria
country: South Africa
facility: Into Research
city: Pretoria
country: South Africa
facility: Seeber, M
city: Verulam
country: South Africa
facility: Dr M Duki Research and Trial Site, Verulam
city: Worcester
country: South Africa
facility: Clinical Projects Research
city: Almeria
country: Spain
facility: Hospital Virgen del Mar
city: Alzira
country: Spain
facility: Hospital de la Ribera
city: Badalona
country: Spain
facility: Hospital Germans Trias i Pujol
city: Barcelona
country: Spain
facility: Specialist
city: Barcelona
country: Spain
facility: CAP Sarria
city: Barcelona
country: Spain
facility: Hospital Quiron. I.C.U.
city: Centelles
country: Spain
facility: EBA Centelles
city: Madrid
country: Spain
facility: Fundación Jiménez Díaz
city: Malaga
country: Spain
facility: Hospital Regional Universitario de Málaga
city: Segovia
country: Spain
facility: Hospital General de Segovia
city: Sevilla
country: Spain
facility: Hospital Quironsalud Infanta Luisa
city: Sevilla
country: Spain
facility: Hospital Virgen Macarena
city: Valencia
country: Spain
facility: Hospital General Universitario de Valencia
city: Valencia
country: Spain
facility: Hospital Dr. Peset
city: Villamartin
country: Spain
facility: Hospital Virgen de las Montañas, Villamartin
city: Kaohsiung
country: Taiwan
facility: Kaohsiung Medical University Chung-Ho Memorial Hospital
city: Kaohsiung
country: Taiwan
facility: Kaohsiung Veterans General Hospital
city: New Taipei City
country: Taiwan
facility: Far Eastern Memorial Hospital
city: Taichung
country: Taiwan
facility: China Medical University Hospital
city: Tainan
country: Taiwan
facility: NCKUH
city: Taipei
country: Taiwan
facility: National Taiwan University Hospital
city: Taipei
country: Taiwan
facility: Taipe Veterans General Hospital
city: Taoyuan County
country: Taiwan
facility: Chang-Gung Memorial Hospital, Linkou
city: Chernivtsi
country: Ukraine
facility: Chernivtsi Regional Endocrinology Dispensary
city: Ivano-Frankivsk
country: Ukraine
facility: Regional CH Dept of Endocrinology SHEI Ivano-Frankivsk NMU
city: Ivano-Frankivsk
country: Ukraine
facility: CI Ivano-Frankivsk Reg Cl Card Center
city: Kharkiv
country: Ukraine
facility: L.T. Malaya Institute of Therapy AMS of Ukraine
city: Kharkiv
country: Ukraine
facility: CIPH Prof. O.I. Meshchaninov Kharkiv CCH of A&E
city: Kharkiv
country: Ukraine
facility: CI of Healthcare Kharkiv CCH #8, Kharkiv
city: Kyiv
country: Ukraine
facility: KCCC of Endocr Dept of General Endocrine Pathology
city: Kyiv
country: Ukraine
facility: City Clinical Hospital No. 1, Kiev
city: Kyiv
country: Ukraine
facility: V.P. Komisarenko Inst. of Endocrinology and Metabolism
city: Kyiv
country: Ukraine
facility: Kjiv City Oleksandrivska Clinical Hospital
city: Kyiv
country: Ukraine
facility: LLC Treatment and Diagnostic Center Adonis Plus, Kyiv
city: Kyiv
country: Ukraine
facility: SI National Scientific Centre of Radiation Medicine of NAMSU
city: Kyiv
country: Ukraine
facility: P.L. Shupyk NMA of PGE Ch of D H for S-ts of NASU
city: Kyiv
country: Ukraine
facility: SI V.P.Komisarenko Institute of Endocrinology and Metabolism
city: Lviv
country: Ukraine
facility: Lviv Regional Endocrinology Dispensary
city: Poltava
country: Ukraine
facility: M.V. Sklifosovskyi Poltava RCH, Poltava
city: Sumy
country: Ukraine
facility: CI Sumy City Clinical Hospital #1 Dept of Therapy Sumy SU
city: Ternopli
country: Ukraine
facility: CI of TRC Ternopil UH
city: Vinnytsia
country: Ukraine
facility: Private Small Enterprise Medical Center Pulse
city: Vinnytsia
country: Ukraine
facility: Vinnytsia RC Highly Special.Endocr.Center Dept of Therapy
city: Vinnytsia
country: Ukraine
facility: M.I. Pyrogov VRCH, Vinnytsia
city: Vinnytsia
country: Ukraine
facility: CCH #1 M.I. Pyrogov VNMU Ch of Propaedeutics of IM
city: Zaporizhzhia
country: Ukraine
facility: CI Zapor CCH#10 SI ZMA PGE Ch of therapy clin pharmacol & endocrin
city: Airdrie
country: United Kingdom
facility: University Hospital Monklands
city: Birmingham
country: United Kingdom
facility: Queen Elizabeth Hospital
city: Bradford on Avon
country: United Kingdom
facility: Bradford on Avon Health Centre
city: Chesterfield
country: United Kingdom
facility: Ashgate Medical Practice
city: Dumfries
country: United Kingdom
facility: Dumfries and Galloway Royal Infirmary
city: Dundee
country: United Kingdom
facility: Ninewells Hospital & Medical School
city: Exeter
country: United Kingdom
facility: Royal Devon and Exeter Hospital
city: Glasgow
country: United Kingdom
facility: Glasgow Royal Infirmary
city: Leicester
country: United Kingdom
facility: Leicester General Hospital
city: London
country: United Kingdom
facility: Barts and The London School of Medicine and Dentistry
city: Swansea
country: United Kingdom
facility: Morriston Hospital
city: Welwyn Garden City
country: United Kingdom
facility: Queen Elizabeth II Hospital
city: Wolverhampton
country: United Kingdom
facility: New Cross Hospital
Study officials:
affiliation: Boehringer Ingelheim
name: Boehringer Ingelheim
role: STUDY_CHAIR
References:
citation: Verhagen C, Janssen J, Minderhoud CA, van den Berg E, Wanner C, Passera A, Johansen OE, Biessels GJ. Chronic kidney disease and cognitive decline in patients with type 2 diabetes at elevated cardiovascular risk. J Diabetes Complications. 2022 Oct;36(10):108303. doi: 10.1016/j.jdiacomp.2022.108303. Epub 2022 Aug 31.
citation: Verhagen C, Janssen J, Exalto LG, van den Berg E, Johansen OE, Biessels GJ. Diabetes-specific dementia risk score (DSDRS) predicts cognitive performance in patients with type 2 diabetes at high cardio-renal risk. J Diabetes Complications. 2020 Oct;34(10):107674. doi: 10.1016/j.jdiacomp.2020.107674. Epub 2020 Jul 16.
citation: Perkovic V, Toto R, Cooper ME, Mann JFE, Rosenstock J, McGuire DK, Kahn SE, Marx N, Alexander JH, Zinman B, Pfarr E, Schnaidt S, Meinicke T, von Eynatten M, George JT, Johansen OE, Wanner C; CARMELINA investigators. Effects of Linagliptin on Cardiovascular and Kidney Outcomes in People With Normal and Reduced Kidney Function: Secondary Analysis of the CARMELINA Randomized Trial. Diabetes Care. 2020 Aug;43(8):1803-1812. doi: 10.2337/dc20-0279. Epub 2020 May 22.
citation: Biessels GJ, Verhagen C, Janssen J, van den Berg E, Zinman B, Rosenstock J, George JT, Passera A, Schnaidt S, Johansen OE; CARMELINA Investigators. Effect of Linagliptin on Cognitive Performance in Patients With Type 2 Diabetes and Cardiorenal Comorbidities: The CARMELINA Randomized Trial. Diabetes Care. 2019 Oct;42(10):1930-1938. doi: 10.2337/dc19-0783. Epub 2019 Aug 9.
citation: McGuire DK, Alexander JH, Johansen OE, Perkovic V, Rosenstock J, Cooper ME, Wanner C, Kahn SE, Toto RD, Zinman B, Baanstra D, Pfarr E, Schnaidt S, Meinicke T, George JT, von Eynatten M, Marx N; CARMELINA Investigators. Linagliptin Effects on Heart Failure and Related Outcomes in Individuals With Type 2 Diabetes Mellitus at High Cardiovascular and Renal Risk in CARMELINA. Circulation. 2019 Jan 15;139(3):351-361. doi: 10.1161/CIRCULATIONAHA.118.038352.
citation: Rosenstock J, Perkovic V, Johansen OE, Cooper ME, Kahn SE, Marx N, Alexander JH, Pencina M, Toto RD, Wanner C, Zinman B, Woerle HJ, Baanstra D, Pfarr E, Schnaidt S, Meinicke T, George JT, von Eynatten M, McGuire DK; CARMELINA Investigators. Effect of Linagliptin vs Placebo on Major Cardiovascular Events in Adults With Type 2 Diabetes and High Cardiovascular and Renal Risk: The CARMELINA Randomized Clinical Trial. JAMA. 2019 Jan 1;321(1):69-79. doi: 10.1001/jama.2018.18269.
citation: Rosenstock J, Perkovic V, Alexander JH, Cooper ME, Marx N, Pencina MJ, Toto RD, Wanner C, Zinman B, Baanstra D, Pfarr E, Mattheus M, Broedl UC, Woerle HJ, George JT, von Eynatten M, McGuire DK; CARMELINA(R) investigators. Rationale, design, and baseline characteristics of the CArdiovascular safety and Renal Microvascular outcomE study with LINAgliptin (CARMELINA(R)): a randomized, double-blind, placebo-controlled clinical trial in patients with type 2 diabetes and high cardio-renal risk. Cardiovasc Diabetol. 2018 Mar 14;17(1):39. doi: 10.1186/s12933-018-0682-3.