Clinical trial NCT06555978: Ageing BIOmarker Study in Singaporeans
Official title: Ageing BIOmarker Study in Singaporeans (ABIOS)
Study type: OBSERVATIONAL
Overall status: ACTIVE_NOT_RECRUITING
Conditions: Healthy Aging
Biological Aging
Lifestyle Factors
Keywords: Aging
Biological Clocks
DNA methylation
Geroscience
Lifestyle
Lead sponsor: National University of Singapore
Sponsor class: OTHER
First posted: 2024-08-15
Enrollment: 420
Sex: ALL
Minimum age (years): 21
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: COHORT
Time perspective: CROSS_SECTIONAL
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Adults 21 years of age or greater who has lived in Singapore for at least 5 consecutive years and is of Chinese, Malay, or Indian ethnicity

Brief summary: The Ageing BIOmarker Study in Singaporeans (ABIOS) aims to understand the biological aging processes and how they affect health among people in Singapore. As people grow older, their risk of developing chronic diseases increases. This study aims to better understand the biological changes that come with age, particularly in three major ethnic groups: Chinese, Malay, and Indian adults over 21 years old. By examining a range of health indicators such as DNA methylation, inflammation, metabolism, cardiovascular health, physical function, and physical activity (i.e., molecular, physiological, and digital biomarkers of ageing), the study seeks to identify how ethnicity, lifestyle, and socioeconomic factors influence ageing. This unique study focuses on an all-Asian population, aiming to enhance our understanding of healthy aging across different ethnic groups.

Detailed description: Biological ageing is the primary driver of age-associated chronic diseases in older adults. Asian populations have been underrepresented in studies developing biological age predictors and understanding age-related diseases. Thus, the Ageing BIOmarker Study in Singaporeans (ABIOS) aims to characterise the biomarkers of ageing in Singaporeans, exploring associations between molecular, physiological, and digital biomarkers of ageing.

This is a single-centre, cross-sectional study that recruits healthy community-dwelling adults (≥ 21 years) from three different ethnic groups (Chinese, Malay, and Indian). Molecular biomarkers of ageing include a multi-omics approach, such as DNA methylation and metabolic and inflammatory parameters in blood, saliva, and stool. Physiological biomarkers of ageing include bone density, body composition, skin autofluorescence, arterial stiffness, physical performance (e.g., muscle strength and flexibility), cognition, and nutritional status. Digital biomarkers of ageing include three-dimensional facial morphology and objective physical activity. Additional factors such as habitual physical activity, dietary patterns, and medical history are also examined. The associations between the molecular, physiological, and digital phenotypes will be explored.

By examining diverse age-related biomarkers, clinical indicators, and lifestyle factors, ABIOS will offer unique insights into the ageing process within these ethnic groups to develop health policies and interventions for promoting healthy ageing in an all-Asian population.

Eligibility criteria: Inclusion Criteria:

* ≥21 years of age
* Chinese, Malay, or Indian and has lived in Singapore for at least 5 consecutive years
* Apparently healthy and non-smokers
* Having only 1 condition (if ≥45 and \<65 years) or any condition (if ≥65 years), and all conditions were medication-controlled (if any):

  * Hypertension
  * Hyperlipidemia
  * Hyperglycemia
  * Osteopenia/osteoporosis
  * Osteoarthritis
  * Type 2 diabetes

Exclusion Criteria:

* Body mass index (BMI) ≥30 kg/m\^2
* Pre-existing or history of major cardiovascular disease (e.g., coronary artery disease, heart failure, stroke, peripheral vascular disease)
* Any metal implants (excluding dental implants) in the body
* Pre-existing or history of cancer or chronic obstructive pulmonary disease (COPD)
* Pregnant women or planning pregnancy in the next 6-12 months

Primary outcomes:
measure: blood DNA methylation
timeFrame: Baseline
Secondary outcomes:
measure: Carotid-femoral Pulse Wave Velocity
timeFrame: Baseline
measure: Handgrip strength
timeFrame: Baseline
measure: 8-repetition maximal strength
timeFrame: Baseline
measure: Skin autofluorescence
timeFrame: Baseline
measure: Objective physical activity
timeFrame: Baseline
measure: Facial age
timeFrame: Baseline
measure: Complete red blood cell (RBC) count
timeFrame: Baseline
measure: Total white blood cell (WBC) count
timeFrame: Baseline
measure: Total cholesterol
timeFrame: Baseline
measure: HDL cholesterol
timeFrame: Baseline
measure: LDL cholesterol
timeFrame: Baseline
measure: Triglycerides
timeFrame: Baseline
measure: Fasting blood glucose
timeFrame: Baseline
measure: Total protein
timeFrame: Baseline
measure: Total bilirubin
timeFrame: Baseline
measure: Alkaline phosphatase (ALP)
timeFrame: Baseline
measure: Insulin
timeFrame: Baseline
measure: HbA1c
timeFrame: Baseline
Other outcomes:
measure: Blood pressure
timeFrame: Baseline
measure: Waist-to-hip ratio
timeFrame: Baseline
measure: Bone mineral density
timeFrame: Baseline
measure: Fat-free mass
timeFrame: Baseline
measure: Fat mass
timeFrame: Baseline
measure: Arm curl repetitions
timeFrame: Baseline
measure: Backscratch test
timeFrame: Baseline
measure: Sit-to-stand repeitions
timeFrame: Baseline
measure: 4-metre walk
timeFrame: Baseline
measure: Habitual physical activity
timeFrame: Baseline
measure: Cognitive function
timeFrame: Baseline
measure: Frailty
timeFrame: Baseline
measure: Risk of malnutrition
timeFrame: Baseline
measure: Saliva DNA methylation status
timeFrame: Baseline
Locations:
city: Singapore
country: Singapore
facility: Centre for Healthy Longevity at Alexandra Hospital
Study officials:
affiliation: National University of Singapore
name: Andrea Maier, MD, PhD
role: PRINCIPAL_INVESTIGATOR
References: