Clinical trial NCT03778489: Impact of Aerobic Exercise Training on Sympathetic Vasoconstriction and Vascular Function in Essential Hypertension
Official title: Impact of Aerobic Exercise Training on Sympathetically Mediated Vasoconstriction and Vascular Function in Individuals With Essential Hypertension (IMPROVEH)
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Hypertension,Essential
Keywords: Pannexin-1 channel
Lead sponsor: University of Copenhagen
Sponsor class: OTHER
Collaborators: name: Lundbeck Foundation
name: Danish Council for Independent Research
First posted: 2018-12-19
Enrollment: 30
Sex: ALL
Minimum age (years): 35
Maximum age (years): 65
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Intervention model description: Randomized double blinded case-control interventional study
Primary purpose: BASIC_SCIENCE

Brief summary: Sympathetic nervous activity plays an important role in the development of hypertension and studies have shown that the pannexin-1 channel is involved in the signalling of the sympathetic activity to the vascular bed. The main project aim is to investigate the effects of 10 weeks of high intensity training on the effect of the sympathetic nervous activity on vascular function in individuals with essential hypertension. A secondary aim is to assess the role of essential hypertension and physical activity on vascular endothelial function,


Eligibility criteria: Inclusion Criteria:

* Sedentary men and women age 35 - 65 years
* Resting blood pressure \>140/90 mmHg or Resting blood pressure \<140/90 mmHg
* Essential hypertension
* Non or exclusively antihypertensive medication

Exclusion Criteria:

* Hypertensive condition other than essential hypertension
* Other chronical diseases
* Smoking
* Excess alcohol intake or drug abuse

Primary outcomes:
measure: Blood pressure
timeFrame: Before and after 8 weeks of training
Secondary outcomes:
measure: Pannexin channel function assessed in vivo
timeFrame: Before and after 8 weeks of training
measure: Pannexin channel distribution in skeletal muscle tissue
timeFrame: Before and after 8 weeks of training
measure: Sympathetic activity
timeFrame: Before and after 8 weeks of training
measure: Vascular function
timeFrame: Before and after 8 weeks of training
measure: Mitochondrial function in endothelial cells
timeFrame: Before and after 8 weeks of training
measure: Reactive oxygen species formation in in endothelial cells
timeFrame: Before and after 8 weeks of training
measure: Rheology
timeFrame: Before and after 8 weeks of training
measure: Platelet reactivity
timeFrame: Before and after 8 weeks of training
measure: Maximal oxygen uptake
timeFrame: Before and after 8 weeks of training
measure: Body Composition
timeFrame: Before and after 8 weeks of training
measure: Endothelial cell characterization
timeFrame: Before and after 8 weeks of training
measure: Skeletal muscle characterization
timeFrame: Before and after 8 weeks of training
Other outcomes:
Locations:
city: Copenhagen
country: Denmark
facility: University of Copenhagen
Study officials:
References:
citation: Moller S, Hansen CC, Ehlers TS, Tamariz-Ellemann A, Tolborg SAR, Kurell ME, Perez-Gomez J, Patrzalek SS, Maulitz C, Hellsten Y, Gliemann L. Exercise Training Lowers Arterial Blood Pressure Independently of Pannexin 1 in Men with Essential Hypertension. Med Sci Sports Exerc. 2022 Sep 1;54(9):1417-1427. doi: 10.1249/MSS.0000000000002936. Epub 2022 Apr 12.