Clinical trial NCT06627309: Rapid DFLC Response Predict CHR in AL Amyloidosis
Official title: Rapid DFLC Response Predict Complete Hematologica Response in Systemic AL Amyloidosis Patients Treated with Daratumumab-based Regimen
Study type: OBSERVATIONAL
Overall status: RECRUITING
Conditions: Systemic AL Amyloidosis
Keywords: rapid dFLC response
daratumumab
systemic al amyloidosis
Lead sponsor: Peking University People's Hospital
Sponsor class: OTHER
First posted: 2024-10-04
Enrollment: 50
Sex: ALL
Minimum age (years): 18
Maximum age (years): 99
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: Systemic AL amyloidosis patients with evaluable hematologic parameter

Brief summary: Light chain amyloidosis (AL amyloidosis) is a rare plasma cell dyscrasia characterized by the deposition of insoluble amyloid fibrils in multiple organ systems. The treatment of amyloidosis primarily relies on anti-plasma cell therapy and supportive care. The application of anti-plasma cell therapy has significantly improved outcomes in patients with AL amyloidosis. Standard first-line therapy typically includes daratumumab, bortezomib, cyclophosphamide, and dexamethasone (Dara-BCD), achieving a complete hematologic response in nearly 60% of patients.The depth and speed of the hematologic response are strongly correlated with organ response and overall survival. An early achievement of a complete hematologic response is particularly crucial in cases of AL amyloidosis characterized by significant organ involvement. The median time to a hematologic response for the daratumumab based treatment is only 7-9 days. The retrospective data showed that the hematologic response in Day 7 in Cycle 1 (C1D7) may predict the complete hematologic response rate. In order to validate the conclusion, the investigator design this prospective study.


Eligibility criteria: Inclusion Criteria:

1. Diagnosis of systemic AL amyloidosis;
2. Daratumumab, bortezomib, dexamethasone used in treatment;
3. Informed consent explained to, understood by and signed by the patient;
4. dFLC ≥ 50 mg/L;

Exclusion Criteria:

1. Fulfill with the criteria of active multiple myeloma or active lymphoplasmacytic lymphoma;
2. Presence of other tumors which is/are in advanced malignant stage and has/have systemic metastasis;
3. Severe or persistent infection that cannot be effectively controlled;
4. Presence of severe autoimmune diseases or immunodeficiency disease;
5. Patients with active hepatitis B or hepatitis C (\[HBVDNA+\] or \[HCVRNA+\]); Patients with HIV infection or syphilis infection;
6. Any situations that the researchers believe will increase the risks for the subject or affect the results of the study.

Primary outcomes:
measure: Complete hematologic response
timeFrame: 6 months
Secondary outcomes:
measure: Overall hematologic response
timeFrame: 6 months
measure: At least one organ response
timeFrame: 12 months
measure: Minimal residual disease
timeFrame: 6 months, 12 months
measure: TTNT
timeFrame: 12 months
measure: MOD-EFS
timeFrame: 12 months
measure: MOD-PFS
timeFrame: 12 months
Other outcomes:
Locations:
city: Beijing
country: China
facility: Peking University People's Hospital
state: Beijing
city: Beijing
country: China
facility: Fuxing Hospital affiliated to Capital Medical University
state: Beijing
Study officials:
References: