Clinical trial NCT06859996: CORE (Cognitive Optimization Through Rehabilitation and Education) Study
Official title: A Comparison of Two Interventions for Chronic Cognitive Difficulties After mTBI
Study type: INTERVENTIONAL
Overall status: NOT_YET_RECRUITING
Phase: NA
Conditions: Mild Traumatic Brain Injury; Concussion
Keywords: cognitive training
self-management
Veterans
concussion
psychoeducation
clinical trial
Lead sponsor: University of Washington
Sponsor class: OTHER
Collaborators: name: National Institute on Disability, Independent Living, and Rehabilitation Research
name: VA Puget Sound Health Care System
First posted: 2025-03-05
Enrollment: 354
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: Mild traumatic brain injury (mTBI) affects millions of individuals worldwide every year. It has long been thought that the vast majority of individuals who sustain a mTBI experience natural recovery with little or no intervention and return to baseline functioning within days to weeks of injury. However, recent large studies have demonstrated that a substantial number of individuals experience prolonged symptoms (e.g., cognitive impairment, headaches, affective symptoms). These symptoms, termed "Persistent Post-concussive Symptoms" (PPCS) are associated with significant functional disability and reduced quality of life (QOL) and can last for years post-injury. While PPCS can include affective, cognitive, and somatosensory/vestibular symptoms, objective and subjective cognitive symptoms - particularly in the domains of attention, memory, processing speed, and executive function - are among the most commonly reported following mTBI. There is currently no gold-standard intervention to address these symptoms. To address this gap, our research group developed a brief cognitive rehabilitation intervention called Tools for Rehabilitation and Cognitive Care (or On-TRACC).

The goals of this clinical trial are:

AIM 1: Compare the efficacy of On-TRACC to a psychoeducation control on reduction of self-reported cognitive post-concussive symptoms (Aim 1.1) and overall neurobehavioral post concussive symptoms and (Aim 1.2) following treatment and at 3-month follow-up (Aim 1.3) in a randomized clinical trial of community-dwelling adults with mTBI.

AIM 2: Compare the efficacy of On-TRACC and psychoeducation on change in secondary outcomes, including cognitive self-efficacy, compensatory strategy use, self-management skills, and quality of life at post-treatment and 3-month follow-up.

Exploratory AIM 3: Compare the efficacy of On-TRACC and psychoeducation on: primary and secondary outcomes at 6-months post-treatment and (Aim 3.1) explore whether engaging in On-TRACC leads to subsequent engagement in care by assessing whether there is a different level of participation in optional intervention booster sessions in the post-intervention period (Aim 3.2).

All participants will:

* Complete a series of assessments
* Complete 6 treatment sessions via telehealth (either On-TRACC or psychoeducation)

All participants will have the option of:

* Attending weekly "Booster Sessions" between 3 and 6-months post-treatment
* Completing neuropsychological assessments at 2 timepoints during the study


Eligibility criteria: Inclusion Criteria:

* \>18 years of age
* Evidence of self-reported mTBI sustained in adulthood at least 3 months prior to the date of study enrollment (clinical discretion allowed for mTBI in late adolescence) AND documentation of diagnosed or suspected mTBI as defined by American Congress of Rehabilitation Medicine (ACRM) criteria in the medical record (e.g., on the problem list, has a diagnosis, encounter for a TBI, diagnosis via a TBI evaluation, or documented in a clinical note, etc).
* Endorsement of at least moderate symptoms (score of 3 or higher) on at least one of the cognitive items (forgetfulness, poor concentration, taking longer to think) from the Rivermead Postconcussion Symptom Questionnaire.
* Ability to read, speak and understand English enough to participate in healthcare in English without a translator.
* Willingness to participate in audio-recorded treatment sessions.
* Willingness to be randomized to treatment condition.
* Willingness to use clinical video teleconferencing (CVT) for research appointments (including be on camera for treatment sessions).
* Able to use and have access to a smart phone, tablet, or computer with internet access in private setting for treatment sessions.

Exclusion Criteria:

* History of neurologic injury or illness other than mTBI that can affect cognitive functioning (e.g., any lifetime severe TBI \[Glasgow Coma Score (GCS)\<=8; loss of consciousness (LOC)\> 1 hour; posttraumatic amnesia (PTA)\>1 week\], seizure disorder, multiple sclerosis, neurodegenerative disorder).
* Alcohol abuse (operationalized as scoring 15 or more if male or 13 or more if female on the Alcohol Use Disorders Identification Test), or high-risk illicit drug use (as defined by modified Tobacco, Alcohol, Prescription Medications and Substance Use/Misuse (TAPS) Tool subscale scores \> 2) in the past 3 months. Indication of alcohol/drug abuse or dependence in medical record is also sufficient to meet this exclusion criteria, per PI discretion.
* Active suicidal ideation/intent indicating significant risk, per PI discretion.
* Unstable medical or psychiatric condition (e.g., mania, psychotic symptoms) that would interfere with study participation.
* Behavioral issues noted in the record or observed during the screening process that would interfere with appropriate or safe CVT participation or study procedures.
* Prior participation in the On-TRACC intervention.
* Significant cognitive impairment that would limit ability to engage in treatment (as indicated by more than 1 error on a 6-item screener).
* Planned life events that would interfere with study participation during active treatment phase (e.g., major surgery, moving out of state, extended travel).

Primary outcomes:
measure: Neurobehavioral Symptom Inventory Total Score
timeFrame: Pre-treatment, Immediately post-treatment, 3-months post-treatment
measure: Neurobehavioral Symptom Inventory Cognitive Subscale Score
timeFrame: Pre-treatment, Immediately post-treatment, 3-months post-treatment
Secondary outcomes:
measure: Cognitive Concerns Self-Efficacy Scale
timeFrame: Pre-treatment, Immediately post-treatment, 3-months post-treatment
measure: Compensatory Cognitive Strategies Scale
timeFrame: Pre-treatment, Immediately post-treatment, 3-months post-treatment
measure: Patient Global Impression of Change
timeFrame: Pre-treatment, Immediately post-treatment, 3-months post-treatment
measure: Quality of Life After Brain Injury
timeFrame: Pre-treatment, Immediately post-treatment, 3-months post-treatment
measure: Self-Management Assessment Scale
timeFrame: Pre-treatment, Immediately post-treatment, 3-months post-treatment
Other outcomes:
Locations:
city: Seattle
country: United States
facility: VA Puget Sound Health Care System
state: Washington
city: Seattle
country: United States
facility: University of Washington
state: Washington
Study officials:
affiliation: University of Washington
name: Kathleen Pagulayan, PhD
role: PRINCIPAL_INVESTIGATOR
affiliation: VA Puget Sound Health Care System
name: Rhonda Williams, PhD
role: PRINCIPAL_INVESTIGATOR
References:
citation: Pagulayan KF, Rau HK, Sheppard DP, Shulein OM, Onstad-Hawes E, Hoffman JM, Williams RM. On-TRACC Pilot Study: A Novel Intervention for Persistent Post-Concussive Cognitive Symptoms. J Head Trauma Rehabil. 2025 Jan 24. doi: 10.1097/HTR.0000000000001014. Online ahead of print.