Clinical trial NCT02258607: Efficacy and Safety of Momelotinib Combined With Trametinib in Adults With Metastatic KRAS-mutated Non-Small Cell Lung Cancer (NSCLC) Who Have Failed Platinum-Based Chemotherapy Preceded by a Dose-finding Lead-in Phase
Official title: A Phase 1b With Expansion Study Evaluating the Efficacy and Safety of Momelotinib Combined With Trametinib in Subjects With Metastatic KRAS-mutated Non-Small Cell Lung Cancer (NSCLC) Who Have Failed Platinum-Based Chemotherapy Preceded by a Dose-finding Lead-in Phase
Study type: INTERVENTIONAL
Overall status: TERMINATED
Phase: PHASE1
Conditions: Relapsed Metastatic KRAS-Mutated Non-Small Cell Lung Cancer
Lead sponsor: Sierra Oncology LLC - a GSK company
Sponsor class: INDUSTRY
First posted: 2014-10-07
Enrollment: 21
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NON_RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: This study is conducted in two phases. The Dose-finding Lead-in Phase, Part A, will evaluate the safety and determine the maximum tolerated dose (MTD) of momelotinib (MMB) when combined with trametinib. Once the MTD of momelotinib (MMB) is determined, the study will proceed to the Dose-finding Lead-in Phase, Part B, to determine the MTD of trametinib. After the MTD is established, the study may proceed to an expansion phase to determine the efficacy, safety, and tolerability of MMB combined with trametinib at the MTD in participants with kirsten rat sarcoma viral oncogene homolog (KRAS) mutated metastatic non-small cell lung cancer (NSCLC). Each treatment cycle will consist of 28 days and treatment will continue in the absence of disease progression, unacceptable toxicity, consent withdrawal, or participant's refusal of treatment.


Eligibility criteria: Key Inclusion Criteria:

* Individuals with KRAS-mutated metastatic or recurrent non-small cell lung cancer
* Radiologic documentation of disease progression
* Measurable disease per RECIST v1.1
* Adequate organ function defined as follows:

  * Hepatic: Total conjugated bilirubin ≤ 1.25 x upper limit of normal (ULN); aspartate transaminase (AST) and alanine transaminase (ALT) \< 3 x upper limit of normal (ULN) or \< 5 x ULN in the setting of liver metastases
* Hematological: Absolute neutrophil count (ANC) ≥ 1.5 x 10\^9/L, platelet ≥ 100 x 10\^9/L, hemoglobin ≥ 9 g/dL

  * Renal: Serum creatinine \< 1.5 x ULN OR calculated creatinine clearance (CLcr) ≥ 60 ml/min
* Adequate left ventricular ejection fraction (LVEF) ≥ 50%
* Eastern Cooperative Oncology Group (ECOG) Performance Status of 0 or 1
* Negative serum pregnancy test for females

Key Exclusion Criteria:

* Less than or equal to 3 weeks since receiving treatment with biologic, small molecule, chemotherapy or other agent for non-small cell lung cancer and 28 days since any prior immunotherapy (such as nivolumab)
* History of a concurrent or second malignancy, except for specified exceptions in the protocol or any other cancer that has been in complete remission for ≥ 5 years
* Known positive status for human immunodeficiency virus (HIV)
* Chronic active or acute viral hepatitis A, B, or C infection or hepatitis B or C carrier
* Presence of ≥ Grade 2 peripheral neuropathy
* Brain metastases, or spinal cord compression. Individuals with brain metastases are allowed if they have been treated with irradiation or surgery, are clinically stable without steroid treatment. Individuals with documented leptomeningeal disease are not eligible
* A history of uveitis and/or scleritis
* Retinal pathology beyond normal age-related processes
* Evidence of a retinal vein occlusion on ophthalmological exam or a history of retinal vein occlusion
* History of newly diagnosed or uncontrolled glaucoma/intraocular pressure \> 21 mm Hg as measured by tonography
* Use of daily and/or chronic oral or ocular steroids. Individuals must be off daily steroids for at least 3 weeks prior to enrolling into the trial
* History of interstitial pneumonitis
* History of long QT syndrome or whose corrected QT interval (QTc) measured (Fridericia method) at screening is prolonged (\> 480 ms for males and females)

Note: Other protocol defined Inclusion/Exclusion criteria may apply

Primary outcomes:
measure: For the Dose-finding Lead-in Phase, incidence of dose limiting toxicities (DLTs)
timeFrame: Up to 28 days
measure: For Expansion Phase, disease control rate (DCR) at Week 8
timeFrame: Week 8
Secondary outcomes:
measure: For the Dose-finding Lead-in Phase, disease control rate (DCR) at Week 8
timeFrame: Week 8
measure: For the Dose-finding Lead-in Phase, overall survival
timeFrame: Up to 2 years
measure: For the Dose-finding Lead-in Phase, progression free survival (PFS)
timeFrame: Up to 2 years
measure: For the Dose-finding Lead-in Phase, overall response rate (ORR)
timeFrame: Up to 2 years
measure: For the Dose-finding Lead-in Phase, plasma pharmacokinetics (PK) parameters of momelotinib (MMB) and major metabolite GS-644603 as measured by Cmax and AUCtau
timeFrame: Days 1 and 15 (Cycle 1 only)
measure: For Expansion Phase, overall survival
timeFrame: Up to 2 years
measure: For Expansion Phase, progression free survival (PFS)
timeFrame: Up to 2 years
measure: For Expansion Phase, overall response rate (ORR)
timeFrame: Up to 2 years
Other outcomes:
Locations:
city: Duarte
country: United States
state: California
city: Sacramento
country: United States
state: California
city: Boston
country: United States
state: Massachusetts
city: Fairfax
country: United States
state: Virginia
city: Spokane
country: United States
state: Washington
Study officials:
affiliation: Gilead Sciences
name: Gilead Study Director
role: STUDY_DIRECTOR
References:
citation: Barbie DA, Spira A, Kelly K, Humeniuk R, Kawashima J, Kong S, Koczywas M. Phase 1B Study of Momelotinib Combined With Trametinib in Metastatic, Kirsten Rat Sarcoma Viral Oncogene Homolog-Mutated Non-Small-Cell Lung Cancer After Platinum-Based Chemotherapy Treatment Failure. Clin Lung Cancer. 2018 Nov;19(6):e853-e859. doi: 10.1016/j.cllc.2018.07.004. Epub 2018 Aug 4.