louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT06034756: Temporomandibular Joint Problems and Core Stabilization
Official title: Temporomandibular Joint Problems, Head Posture, Tongue Strength and Endurance and Core Stabilization With University Students
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Temporomandibular Joint Disorders
Core Stability
Keywords: temporomandibular disorders
core stability
head posture
tongue strength
Lead sponsor: Bandırma Onyedi Eylül University
Sponsor class: OTHER
First posted: 2023-09-13
Enrollment: 70
Sex: ALL
Minimum age (years): 18
Maximum age (years): 31
Standard ages: ADULT
Accepts healthy volunteers: yes
Observational model: CASE_ONLY
Time perspective: CROSS_SECTIONAL
Sampling method: PROBABILITY_SAMPLE
Study population: University students

Brief summary: This study aimed to investigate the relationship between temporomandibular joint problems, head posture, tongue strength, and endurance with core stabilization.

Detailed description: This cross-sectional study was conducted on university students aged 18-31 between September 2022 and February 2023. In the evaluation of the students were used that the Fonseca's Anamnestic Questionnaire for temporomandibular joint dysfunction, Research Diagnostic Criteria for Temporomandibular Disorders Examination Form for maximum pain-free mouth opening, presence of sound in temporomandibular joint movements, and palpation parameters of temporomandibular joint and surrounding muscles, Craniovertebral Angle for forward head posture, and Iowa Oral Performance Instrument for tongue strength and endurance. In addition, the Trunk Flexor Endurance Test and Biering Sorenson Test were used for static endurance of the core muscles, and Sit-ups Test and Modified Push-ups Test were used for dynamic endurance of the core muscles.

Eligibility criteria: Inclusion Criteria:

* University students aged 18 and 31 who agreed to participate in the study
* signed the Informed Consent Form were included.

Exclusion Criteria:

* having a non-reducible disc problem,
* having surgery related to spine, abdomen and/or TMJ problem,
* history of trauma, cancer,
* presence of neurological problems, congenital anomaly, musculoskeletal problems, systemic disease, facial paralysis,
* receiving any treatment related to the spine and TMJ in less than six months.

Primary outcomes:
measure: TMJ dysfunction
timeFrame: September 2022- February 2023
measure: Maximum pain-free mouth opening (MMO)
timeFrame: September 2022- February 2023
measure: Forward head posture
timeFrame: September 2022- February 2023
measure: Tongue strength and endurance
timeFrame: September 2022- February 2023
measure: Static endurance evaluation of the trunk muscles
timeFrame: September 2022- February 2023
measure: Dynamic endurance evaluation of the core muscles:
timeFrame: September 2022- February 2023
Secondary outcomes:
Other outcomes:
Locations:
city: Balıkesir
country: Turkey
facility: Bandırma Onyedi Eylül University
Study officials:
References:
Clinical trial NCT02862756: Analysis of Thrombo-embolic Complications After Endovascular Treatment of Unruptured Intracranial Aneurysms
Official title: Analysis of Thrombo-embolic Complications After Endovascular Treatment of Unruptured Intracranial Aneurysms
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Unruptured Intracranial Aneurysms
Lead sponsor: CHU de Reims
Sponsor class: OTHER
First posted: 2016-08-11
Enrollment: 250
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: BASIC_SCIENCE

Brief summary: Endovascular treatment of ruptured and unruptured intracranial aneurysms presents complications, mainly the thrombo-embolic complication. No specific studies have been conducted to study factors associated with the occurrence of thromboembolic complications (symptomatic or not) post endovascular treatment of intracranial aneurysms.

Detailed description: In this multicenter, prospective study, patients with treatment of unruptured intracranial aneurysms will be recruited. The thromboembolic complications will be research using diffusion-weighted MRI.

Eligibility criteria: Inclusion Criteria:

* patient having a programmed endovascular treatment for unruptured intracranial aneurysm
* patient older than 18 years
* patient consenting to participate to the study
* patient enrolled in the national healthcare insurance program

Exclusion Criteria:

* patients with contraindications for MRI
* patients whose clinical condition does not allow sufficient cooperation to the realization of MRI
* patients with arteriovenous malformation intracranial

Primary outcomes:
measure: Thromboembolic complication
timeFrame: 72 hours after endovascular treatment
Secondary outcomes:
Other outcomes:
Locations:
city: Reims
country: France
facility: Chu de Reims
Study officials:
References:
Clinical trial NCT01027156: The Influence of a High Intensity Physical Activity Intervention on a Selection of Health Related Outcomes: An Ecological Approach
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: To Assess the Impact of the HIT Intervention on Physiological Responses
To Assess the Role of a Secondary High School as a Setting for Promoting Healthy Eating and PA Behaviours
To Determine the Associations Between CVD Risk Factors at Baseline in 15 - 18 Year Old Youth
Keywords: Public Health
Biochemistry
Ecological
Lead sponsor: University of the West of Scotland
Sponsor class: OTHER
Collaborators: name: Swansea University
First posted: 2009-12-07
Sex: ALL
Minimum age (years): 15
Maximum age (years): 18
Standard ages: CHILD
ADULT
Accepts healthy volunteers: yes
Primary purpose: PREVENTION

Brief summary: The purpose of this study is to determine whether a High Intensity exercise intervention can elicit cardiovascular disease protection in adolescents.


Eligibility criteria: Inclusion Criteria:

* Healthy
* 15 - 18 yer old that are capable of performing vigorous exercise

Exclusion Criteria:

* Any health condition that would prevent them from undertaking vigorous exercise

Primary outcomes:
measure: To improve blood lipid profiles and lower levels of plasma inflammatory markers.
Secondary outcomes:
measure: To determine the associations between CVD risk factors at baseline in 15 - 18 year old youth.
Other outcomes:
Locations:
city: Hamilton
country: United Kingdom
facility: Holy Cross High School
state: South Lanarkshire
Study officials:
References:
citation: Buchan DS, Ollis S, Young JD, Cooper SM, Shield JP, Baker JS. High intensity interval running enhances measures of physical fitness but not metabolic measures of cardiovascular disease risk in healthy adolescents. BMC Public Health. 2013 May 24;13:498. doi: 10.1186/1471-2458-13-498.
citation: Buchan DS, Ollis S, Thomas NE, Baker JS. The influence of a high intensity physical activity intervention on a selection of health related outcomes: an ecological approach. BMC Public Health. 2010 Jan 8;10:8. doi: 10.1186/1471-2458-10-8.
Clinical trial NCT05402956: Aerobic Exercise in Persons With Multiple Sclerosis With Restless Legs Syndrome
Official title: Effect of Aerobic Exercise Training in Persons With Multiple Sclerosis With Restless Legs Syndrome
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Multiple Sclerosis
Lead sponsor: Dokuz Eylul University
Sponsor class: OTHER
First posted: 2022-06-02
Enrollment: 30
Sex: ALL
Minimum age (years): 18
Maximum age (years): 65
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Intervention model description: Parallel Assignment
Primary purpose: TREATMENT

Brief summary: In this studly, the effects of an 12-week aerobic exercise training in persons with multiple sclerosis with restless legs syndrome will be investigated.


Eligibility criteria: Inclusion Criteria:

* A relapsing-remitting or secondary progressive type of multiple sclerosis,
* To be willing to participate in the study.

Exclusion Criteria:

* Another neurological disorder,
* Orthopedic surgery history including the ankle-foot, knee, hip, or spine, affecting balance,
* Diagnosed severe cognitive and/or psychiatric impairment,
* Having congestive heart failure, coronary, cerebrovascular, and pulmonary disease such as COPD
* Having cardiac disease such as hypertension that would be a contraindication to exercise

Primary outcomes:
measure: International Restless Legs Syndrome Study Group rating scale for restless legs syndrome
timeFrame: Change from Baseline at 12 weeks
Secondary outcomes:
measure: Timed 25-Foot Walk
timeFrame: Change from Baseline at 12 weeks
measure: 12-Item Multiple sclerosis walking scale
timeFrame: Change from Baseline at 12 weeks
measure: Epworth Sleepiness Scale
timeFrame: Change from Baseline at 12 weeks
measure: Multiple Sclerosis International Quality of Life questionnaire
timeFrame: Change from Baseline at 12 weeks
measure: Pittsburgh Sleep Quality Index
timeFrame: Change from Baseline at 12 weeks
measure: Time Up and Go Test
timeFrame: Change from Baseline at 12 weeks
measure: Six-Minute Walk Test
timeFrame: Change from Baseline at 12 weeks
measure: Two-Minute Walk Test
timeFrame: Change from Baseline at 12 weeks
measure: Estimated VO2 Max
timeFrame: Change from Baseline at 12 weeks
Other outcomes:
measure: Restless Legs Syndrome Diagnostic Criteria
timeFrame: At Baseline
measure: Expanded Disability Status Scale
timeFrame: At Baseline
Locations:
city: Izmir
country: Turkey
facility: Dokuz Eylul University Hospital, MS Outpatient Clinic
Study officials:
References:
Clinical trial NCT01847456: Influence of Brain Insulin Sensitivity on Peripheral Insulin Sensitivity
Official title: Influence of Brain Insulin Sensitivity on Peripheral Insulin Sensitivity
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Insulin Sensitivity
Keywords: whole body insulin sensitivity
insulin action in the brain
Lead sponsor: University Hospital Tuebingen
Sponsor class: OTHER
First posted: 2013-05-06
Enrollment: 10
Sex: MALE
Minimum age (years): 18
Maximum age (years): 35
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: CROSSOVER
Primary purpose: BASIC_SCIENCE

Brief summary: The researchers will investigate if brain insulin action influences peripheral insulin sensitivity in healthy humans.


Eligibility criteria: Inclusion Criteria:

* BMI \< 28 kg/m2
* normal HbA1c
* healthy volunteers

Exclusion Criteria:

* Heparin induced thrombocytopenia (HIT)
* metal implants
* cardial diseases
* anemia
* patients taking any kind of drugs

Primary outcomes:
measure: Insulin sensitivity as measured by clamp
timeFrame: 45 minutes to 120 minutes post nasal spray
Secondary outcomes:
measure: Autonomous nervous system activity
timeFrame: 45 to 120 minutes post spray
Other outcomes:
Locations:
city: Tuebingen
country: Germany
facility: University of Tuebingen, Internal medicine IV
Study officials:
References:
citation: Heni M, Wagner R, Kullmann S, Veit R, Mat Husin H, Linder K, Benkendorff C, Peter A, Stefan N, Haring HU, Preissl H, Fritsche A. Central insulin administration improves whole-body insulin sensitivity via hypothalamus and parasympathetic outputs in men. Diabetes. 2014 Dec;63(12):4083-8. doi: 10.2337/db14-0477. Epub 2014 Jul 15.
Clinical trial NCT05282056: COVID-19 Volumetric Quantification on Computer Tomography Using Computer Aided Diagnostics
Official title: COVID-19 Volumetric Quantification on Computer Tomography Using Computer Aided Diagnostics
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: COVID-19
Keywords: CAD
AI
Artificial Intelligence
Lead sponsor: XVision
Sponsor class: INDUSTRY
Collaborators: name: Pius Brinzeu Timisoara County Emergency Hospital
First posted: 2022-03-16
Enrollment: 200
Sex: ALL
Minimum age (years): 16
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Intervention model description: CAD outputs are turned off for randomly chosen 50% of patients, which represent the control group. The other 50% are analysed using CAD
Primary purpose: DIAGNOSTIC

Brief summary: The aim of the study is to asses the influence of computer aided diagnostic to the process of lung affection quantification on computer tomography in COVID-19 confirmed patients.

Detailed description: The lung involvement of COVID-19 patients has been showed to be correlated to clinical outcomes and became part of the clinical practice. Even though various scores can be used, the affection estimation is usually done on computer tomography, using radiologists's estimation skills which is a highly subjective process.

Artificial intelligence is a known objective constant and therefore a potential radiologist complement. This trial aims at studying the effect of using a computer aided diagnostic software integrated in the normal clinical practice of radiologists from Timisoara County Emergency Hospital. It uses the AI-PROBE analysis setup, which turns off the CAD outputs for randomly chosen 50% the cases (control) and then compares the radiological reports for differences between the two arms.

Eligibility criteria: Inclusion Criteria:

* RT-PCR confirmed patients of COVID-19

Exclusion Criteria:

* 15 or lower

Primary outcomes:
measure: Mean difference of lung affection quantification percentage
timeFrame: At CT acquisition time, up to 2 weeks
Secondary outcomes:
Other outcomes:
Locations:
city: Timisoara
country: Romania
facility: Pius Brinzeu Timisoara County Emergency Hospital
state: Timis
Study officials:
References:
Clinical trial NCT01362556: Blood Gas Analysis and Buffering In Cardiac Arrest
Official title: Blood Gas Analysis and Buffering In Cardiac Arrest - A Multicenter, Prospective, Randomised, Double Blind Prehospital Trial to Evaluate the Impact of Early Blood-gas-analysis Targeted Buffer Therapy on ROSC After OOHCA
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Cardiac Arrest
Lead sponsor: Medical University of Graz
Sponsor class: OTHER
First posted: 2011-05-30
Enrollment: 700
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The debate over the administration of sodium bicarbonate in cardiac arrest has been going on for several decades, swinging like a pendulum from "first-line drug" to "not indicated" to the recent guidelines advocating "a small bolus under special conditions (metabolic acidosis, intoxication, long-term resuscitation)". A targeted, blood-gas controlled application under optimised ventilation conditions has not yet been evaluated prehospitally. Our preliminary studies have shown that an arterial puncture/line as well as measurement of blood gases is feasible in preclinical conditions. This multicentre trial including 5 centres and 10 physician-staffed emergency systems is designed to compare, in a prospective randomised controlled study, the effect of a calculated dosage of sodium bicarbonate based on the patient´s base deficit and weight, on ROSC (= return of spontaneous circulation) and on the secondary survival of cardiac arrest patients. The null hypothesis is that there is no or negative impact on survival.


Eligibility criteria: Inclusion Criteria:

* prehospitally started cardiopulmonary resuscitation (CPR)
* advanced cardiac life support provided
* age \>18 years
* arterial pH \< 7,2
* arterial BE \< -12
* arterial pCO2 15-75 mmHg
* arterial pO2 \>35 mmHg

Exclusion Criteria:

* women of childbearing age
* traumatic cardiac arrest

Primary outcomes:
measure: Rate of return of spontaneous circulation (ROSC)
timeFrame: Within five hours from start of resuscitation.
Secondary outcomes:
measure: Survival to discharge after cardiac arrest
timeFrame: participants will be followed for the duration of hospital stay, an expected average of 5 weeks
measure: Survival after one year of hospital discharge
timeFrame: One year after event
Other outcomes:
Locations:
city: Klagenfurt
country: Austria
facility: Landeskrankenhaus Klagenfurt
state: Carinthia
city: Wiener Neustadt
country: Austria
facility: Landesklinikum Wiener Neustadt
state: Lower Austria
city: Bruck / Mur
country: Austria
facility: Landeskrankenhaus Bruck / Mur
state: Styria
city: Graz
country: Austria
facility: LKH Graz West
state: Styria
city: Graz
country: Austria
facility: Medical University Graz
state: Styria
city: Linz
country: Austria
facility: AKH Linz
state: Upper Austria
Study officials:
affiliation: Medical University of Graz
name: Gerhard Prause, Prof. Dr.
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT02726256: G-CREDIT (Gangnam-Cohort for Risk Evaluation of Diabetes and Impaired Glucose Tolerance)
Study type: OBSERVATIONAL
Overall status: NOT_YET_RECRUITING
Conditions: Type 2 Diabetes
Impaired Glucose Intolerance
Keywords: Diabetes
DM complication
Lead sponsor: Yonsei University
Sponsor class: OTHER
First posted: 2016-04-01
Enrollment: 500
Sex: ALL
Minimum age (years): 20
Maximum age (years): 100
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Patients with either type 2 diabetes or impaired glucose toloerance who are older than 20 years old and have attended Gangnam Severance hospital for regular follow up.

Brief summary: The prevalence of type 2 diabetes has consistently increased and type 2 diabetes can cause many types of vascular complications. Diabetes develops due to glucose intolerance. Early detection and intervention in the stage of glucose intolerance makes it afford to prevent overt diabetes and its complications. This study was designed to make a cohort of korean patients with glucose intolerance to construct a long term database about clinical characteristics of these patients.


Eligibility criteria: Inclusion Criteria:

1. Patients older than 20 years old who has visited Gangnam severance hospital since January 2007.
2. Patients with either diabetes or impaired glucose tolerance
3. Patients with at least 6 months of follow-up period

Exclusion Criteria:

1. Patients with gestational diabetes, any active stage of cancer and severe disability

Primary outcomes:
measure: Life style assessment - Past medical history - Smoking, alcohol history - Sleep, exercise, daily activity check - Diet - Reproductive status (Women only) - Socioeconomic status
timeFrame: an expected average of 12 weeks
measure: Past medical history
timeFrame: an expected average of 12 weeks
measure: Smoking, alcohol history
timeFrame: an expected average of 12 weeks
measure: Sleep, exercise, daily activity check
timeFrame: an expected average of 12 weeks
measure: Diet
timeFrame: an expected average of 12 weeks
measure: Reproductive status (Women only)
timeFrame: an expected average of 12 weeks
measure: Socioeconomic status
timeFrame: an expected average of 12 weeks
measure: Anthropometric measurements : Height, weight, waist circumference, pulse rate, blood pressure
timeFrame: an expected average of 12 weeks
measure: SMA, TG, HDL, LDLM apoA, apoB
timeFrame: an expected average of 12 weeks
measure: PC2hrs, HbA1C, Insulin, C-peptide (AC, PC2hr), hs-CRP
timeFrame: an expected average of 12 weeks
measure: Urine protein, albumin, creatinine
timeFrame: an expected average of 12 weeks
measure: EKG, Neurometer, Chest PA, Abdominal sonography
timeFrame: an expected average of 12 weeks
measure: Fundus photography, fat computed tomography
timeFrame: an expected average of 12 weeks
measure: HOMA-IR, HOMA-β
timeFrame: an expected average of 12 weeks
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
References:
Clinical trial NCT01454856: Perioperative Evaluation of Immuno-inflammatory Parameters
Official title: Perioperative Evaluation of Immuno-inflammatory Parameters
Study type: OBSERVATIONAL
Overall status: TERMINATED
Conditions: Combined Inflammatory and Immunologic Defect
Lead sponsor: Université Catholique de Louvain
Sponsor class: OTHER
First posted: 2011-10-19
Enrollment: 20
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: Cohort of patients

Brief summary: This study consists of evaluations, using blood tests, various immune, inflammatory and coagulation parameters in the perioperative settings (different substudies), without changing anything to what is expected.

This will allow us to clarify the possible impact of surgery and analgesia on perioperative activation of these pathways.

Detailed description: A significant number of published data can be concluded that surgery and anesthetic and analgesic techniques have an impact on immunity and inflammation.

However, none of these studies have been performed with modern techniques, much more reliable evaluation of immune activity, such as the assessment of monocytic degranulation by flow cytometry.

It is therefore important to document immune activity using these new techniques, our patients, perioperative. This will be analyzed, so observational, the potential impact of different therapeutic interventions the patient receives.

This study consists of evaluations, using blood tests, various immune, inflammatory and coagulation parameters in the perioperative settings (different substudies), without changing anything to what is expected.

This will allow us to clarify the possible impact of surgery and analgesia on perioperative activation of these pathways.

Eligibility criteria: Inclusion Criteria:

* Surgical patients (and controls)

Exclusion Criteria:

* Immune disorders

Primary outcomes:
measure: Immune parameters (immunocytes phenotype)
timeFrame: baseline up to 8 days (return to baseline)
Secondary outcomes:
measure: Long term outcome
timeFrame: 5 years
measure: Coagulation parameters (like platelet function) (substudy)
timeFrame: perioperative period (up to 3 days)
measure: Inflammatory markers (cytokines) (substudy)
timeFrame: baseline up to 8 days (return to baseline)
Other outcomes:
Locations:
city: Brussels
country: Belgium
facility: Cliniques universitaires Saint-Luc
Study officials:
affiliation: UCL
name: Patrice Forget, M.D.
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT04041856: Povidone-iodine 2% Eye Drop Versus Artificial Tear Drop for Treatment of Adenoviral Keratoconjunctivitis
Official title: Povidone-iodine 2% Eye Drop Versus Artificial Tear Drop for Treatment of Adenoviral Keratoconjunctivitis
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: PHASE1
PHASE2
Conditions: Adenoviral Keratoconjunctivitis
Lead sponsor: Farabi Eye Hospital
Sponsor class: OTHER
First posted: 2019-08-01
Enrollment: 200
Sex: ALL
Minimum age (years): 17
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: Povidone-iodine 2% eye drop versus artificial tear drop for treatment of adenoviral keratoconjunctivitis

Detailed description: Diagnosed EKC patients will be devided into two groups,first group will undergo povidone-iodine 2% eye drop four times a day and the control group will be treated only by artificial tear drops,they will be examined 3 months later and evaluations and data collections for the final comparison will be done.

Eligibility criteria: Inclusion Criteria:

* Patients suspected for viral conjunctivitis

Exclusion Criteria:

* Allergic to iodized materials
* Age under 17

Primary outcomes:
measure: Povidone-iodine 2% eye drop versus artificial tear drop for treatment of adenoviral keratoconjunctivitis
timeFrame: 3 months
measure: Povidone-iodine 2% eye drop
timeFrame: 3 months
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
References: