Clinical trial NCT05732688: Drug-screening in AML at Relapse for Targeted Treatment
Official title: Drug-screening in AML at Relapse for Targeted Treatment
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: AML
Keywords: AML
Relapse
Drug-screening
Pharmacoscopy
Lead sponsor: Insel Gruppe AG, University Hospital Bern
Sponsor class: OTHER
First posted: 2023-02-17
Enrollment: 30
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: SCREENING

Brief summary: This is a non-randomised clinical study investigating subsequent patients with specific AML treatment started between January 1, 2022 until December 31, 2022.

Patients with relapsing disease are planned to be analyzed in this study

Detailed description: The standard treatment for young fit patients with acute myeloid leukemia (AML) is intensive chemotherapy followed by consolidation treatment with curative intent. Usually, two cycles of intensive chemotherapy are given, with subsequent consolidation treatment depending on the genetic risk-assessment of the patients as well as on the response to the induction treatment.

For elderly or unfit patients, such an intensive approach is not feasible, and palliative treatment must be considered. The standard first-line-treatment for such patients since more than a decade comprises repetitive cycles of a hypomethylating agent (either Azacitidine or Decitabine). The median progression free survival following these approaches in this population is between 4 and 8 months, with an overall-survival of up to 12 months. More recently, the addition of the Bcl-2 inhibitor Venetoclax to hypomethylating agents has led to a modest improvement both of progression-free and overall survival. However, overall survival in such patients usually does not exceed 14-16 months.

The laboratory of Prof. Berend Snijder, Institute of Molecular Systems Biology, at the ETH (Eidgenössische Technische Hochschule) Zurich has developed an image-based ex-vivo drug screening platform for patients with aggressive haematological malignancies, also called pharmacoscopy. Using such a technique, leukemic cells from a patient at relapse can be rapidly screened for sensitivity to single compounds. A drug score is calculated for each compound.

Starting in Q2/2021, the investigator at the Department of Medical Oncology, University Hospital Inselspital in Bern, collected experiences using such an approach. Having received information from the laboratory on top sensitivity of leukemic cells of a given patient to a specific drug, a process is initiated to try to obtain access to such off-label drugs.

Eligibility criteria: Inclusion Criteria:

* Included are patients with AML at relapse treated at the Department of Medical Oncology at the University Hospital Inselspital in Bern.
* Patients are not planned to undergo intensive reinduction treatment with subsequent allogeneic hematopoietic transplantation in a curative intent.
* Patients have exhausted all standard therapeutic options and they must have no available licensed standard treatment for relapsed AML.
* Written informed consent

Exclusion Criteria:

* Patients able to undergo intensive reinduction treatment with subsequent allogeneic hematopoietic transplantation in a curative intent
* Patients have available standard therapeutic options

Primary outcomes:
measure: Treatment with identified effective drug
timeFrame: 12 months
Secondary outcomes:
measure: Identification of effective drug
timeFrame: 12 months
measure: Duration of response
timeFrame: 12 months
measure: Overall survival
timeFrame: 12 months
measure: Response rate of patients depending on the RBF (relative blast fraction) value
timeFrame: 12 months
measure: Duration of response of patients depending on the RBF (relative blast fraction) value
timeFrame: 12 months
measure: Overall survival of patients depending on the RBF (relative blast fraction) value
timeFrame: 12 months
Other outcomes:
Locations:
city: Berne
country: Switzerland
facility: Departement of Medical Oncology, University Hospital Berne
Study officials:
affiliation: Department for Medical Oncology; University Hospital/Inselspital
name: Thomas Pabst, Prof Dr. med
role: STUDY_CHAIR
References: