louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT06044207: Biomarkers and Risk Factors for Perioperative Neurocognitive Dysfunction in Elderly Patients
Official title: Biomarkers and Risk Factors for Perioperative Neurocognitive Disorders in Elderly Non-neurosurgical Patients
Study type: OBSERVATIONAL
Overall status: RECRUITING
Conditions: Perioperative Neurocognitive Dysfunction
Lead sponsor: Jinan Central Hospital
Sponsor class: OTHER
First posted: 2023-09-21
Enrollment: 1000
Sex: ALL
Minimum age (years): 65
Standard ages: OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Elderly people older than 65 years old who have been identified for non-neurosurgical procedures at Jinan Central Hospital

Brief summary: Basic information and biological samples of patients were collected preoperatively and intraoperatively, and patients were divided into case and control groups by cognitive function assessment postoperatively, and risk factors and biomarkers of perioperative cognitive dysfunction were derived by analyzing and statistically processing basic information and biological samples.


Eligibility criteria: Inclusion Criteria:

* Age more than or equal to 65 years old
* ASA classification Ⅰ\~Ⅲ grade

Exclusion Criteria:

* History of previous Craniocerebral surgery or Craniocerebral trauma
* Inability to successfully complete preoperative psychological function tests
* Those who are severely deaf, speech impaired and otherwise unable to communicate.

Primary outcomes:
measure: Perioperative neurocognitive dysfunction
timeFrame: 1 year postoperative
Secondary outcomes:
Other outcomes:
Locations:
city: Jinan
country: China
facility: Jinan Central Hospital
state: Shandong
Study officials:
References:
Clinical trial NCT04425707: Ivermectin In Treatment of COVID 19 Patients
Official title: The Use of Ivermectin In the Treatment of COVID 19 Patients
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Covid19
Lead sponsor: Ministry of Health and Population, Egypt
Sponsor class: OTHER_GOV
First posted: 2020-06-11
Enrollment: 100
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: as Egypt suffered a lot during the pandemic of COVID 19 with limited drug choices, many of the patients could not acheive viral clearence with the standard module of care teh idea of introduction of new medications in the treatment protocol of COVID 19 managment. Ivermectin had shown a promising results in vitro studies and in limited in vivo studies. this clinical trial may open a new hope for COVID 19 patients as a new and cheap line of treatment

Detailed description: the study will compare the effect of ivermectin in comaprison and addition to the standard mode of care for the COVID 19 patients

Eligibility criteria: Inclusion Criteria:

* Asymptomatic mild cases and moderate cases proven to be infected by COVID 19 by viral RNA swap

Exclusion Criteria:

* Contraindications for the drug: hypersensitivity.
* Any medications with possible drug interactions.
* Severe cases.
* Any malignant condition.
* Pregnant females.
* Breast feeding females.
* Any patient on the following medications: Erdafitinib- Lasmiditan- Quinidine due to potential severe drug interaction.

Primary outcomes:
measure: to evaluate the role of Ivermectin as a line of treatment for COVID 19
timeFrame: 2 months
Secondary outcomes:
measure: To asses the rate of viral clearance in comparison to other treatment protocols.
timeFrame: 2 months
Other outcomes:
Locations:
city: Cairo
country: Egypt
facility: isolation and referal hospitals for COVID 19 patients
Study officials:
affiliation: COVID sceintific comittee ministry of health and population
name: houssam ho masoud, MD
role: STUDY_DIRECTOR
References:
Clinical trial NCT06911307: Exploring the Effectiveness of Unpowered Negative Pressure Wound Therapy
Official title: Exploring the Effectiveness of Unpowered Negative Pressure Wound Therapy: a Randomized Controlled Trial
Study type: INTERVENTIONAL
Overall status: NOT_YET_RECRUITING
Phase: NA
Conditions: Chronic Wound
Acute Wound
Keywords: Negative Pressure Wound Therapy;
wound care
randomized controlled trial
Lead sponsor: Taipei Medical University
Sponsor class: OTHER
Collaborators: name: BenQ Materials Corporation
First posted: 2025-04-04
Enrollment: 160
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The aim of this study is to investigate the effectiveness of Non-powered Negative Pressure Wound Therapy (NPWT) on the healing of abdominal surgical wounds. It is designed as a randomized controlled trial with an experimental group (using NPWT) and a control group (conventional wound care). The study aims to recruit 160 participants: 80 with acute wounds and 80 with chronic wounds. Participants will be randomly assigned to either the experimental group (40 acute wounds, 40 chronic wounds) or the control group (40 acute wounds, 40 chronic wounds). The study will assess wound healing rates and speed, quality of life, self-perceived health status, pain levels, complications, and wound care costs using indicators. Effectiveness will be analyzed using Generalized Estimating Equations (GEE). The study anticipates that results will contribute to evaluating the effects of Non-powered NPWT on wound healing, quality of life, pain, and cost-effectiveness in patients with acute and chronic wounds.


Eligibility criteria: Inclusion Criteria:

1. Patients with acute wounds (wound duration \<4 weeks) or chronic wounds (wound duration ≥4 weeks).
2. Wound depth \<2 cm.
3. Age ≥18 years.
4. Patients who have been evaluated and approved for participation by their attending physician.

Exclusion Criteria:

1. Patients with unstable vital signs.
2. Presence of ischemia in the wound or surrounding tissues.
3. Fragile skin around the wound.
4. Severe wound infection or necrotic tissue.
5. Wound size \>10 × 20 cm.

Primary outcomes:
measure: wound healing
timeFrame: 90days
Secondary outcomes:
measure: Pain Assessment
timeFrame: 90days
measure: Wound-related Quality of Life
timeFrame: 90days
measure: Self-reported Health Status
timeFrame: 90days
measure: Length of Hospital Stay for wound treatment
timeFrame: 90days
measure: Cost Analysis
timeFrame: 90days
measure: Complications and Adverse Events
timeFrame: 90days
measure: Adhesion Issues for Dressing
timeFrame: 90days
measure: Mortality Events
timeFrame: 90days
Other outcomes:
Locations:
Study officials:
References:
Clinical trial NCT05373407: Low Versus Moderate-intensity Aerobic Training in Post-discharge COVID-19 Subjects
Official title: A Randomized Controlled Trial Examining the Impact of Low Versus Moderate-intensity Aerobic Training in Post-discharge COVID-19 Older Subjects
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: COVID-19
Aerobic Exercises
Elderly
Lead sponsor: University of Hail
Sponsor class: OTHER
First posted: 2022-05-13
Enrollment: 72
Sex: ALL
Minimum age (years): 60
Maximum age (years): 80
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The main purpose of this study is to compare the impact of low versus moderate-intensity aerobic training in post-COVID 19 older subjects.

On exercise adherence and changes in physical fitness, psychological status, and quality of life after a 10-week intervention.


Eligibility criteria: Inclusion Criteria:

* Age range of 60 - 80 years with
* diagnosis of post-COVID-19

Exclusion Criteria:

* • History of lower limb surgeries, fractures

  * Cardiac problems
  * Respiratory problems
  * Neurological problems
  * Systemic problems and any other contraindications for aerobic training

Primary outcomes:
measure: Distance walked in the 6-min walk test (6 MWT)
timeFrame: 8 weeks
measure: Post-Covid Functional Scale (PCFS)
timeFrame: 8 weeks
Secondary outcomes:
measure: Number of repetitions performed in a 1-min Sit-to-Stand (STS) test
timeFrame: 8 weeks
measure: 2. Anxiety and Depression evaluated by the HAMLITON ScAnxiety and Depressionale (HADS)
timeFrame: 8 weeks
measure: Quality of life SF-36
timeFrame: 8 weeks
Other outcomes:
Locations:
city: Hail
country: Saudi Arabia
facility: Hail University Poly Clinic
Study officials:
References:
Clinical trial NCT00906607: Prevalence of Urinary Incontinence in Different Age Categories
Official title: Prevalence of the Urinary Incontinence in Adolescents, Young, Adults and Aged
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Urinary Incontinence
Keywords: Urinary Incontinence
Lead sponsor: Universidade de Franca
Sponsor class: OTHER
First posted: 2009-05-21
Enrollment: 78
Sex: FEMALE
Minimum age (years): 10
Maximum age (years): 75
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Sampling method: NON_PROBABILITY_SAMPLE
Study population: The study included 78 nulliparous and nulligest women of different ages living in the city of Franca, and these are divided into: G1 (10-18 years), G2 (20-35 years), G3 (45-60 years) and G4 (65-75 years).

Women with a history of cancer or surgery of the lower urinary tract, urinary tract infection, cognitive changes, pregnancy and obesity, were excluded from this study.

Brief summary: Introduction: Urinary incontinence (UI) is considered erroneously by many as being a phenomenon of the aging process, however there is a growing prevalence of complaints of UI in nulliparous and nulligest young women.

Objective: To investigate the prevalence of urinary incontinence in women of different age groups.

Method: 78 nulliparous and nulligest women of different resident age groups in the city of France, being these divided in: G1 (10-18 years); G2 (20-35 years); G3 (45-60 years) and G4 (65-75 years). Excluded from this study were women with cancer or surgeries of the inferior urinary treatment, urinary infection, alterations cognitive, pregnant and obesity. All the participants were questioned as a perception of urine loss, to the efforts or effortlessly evident.

Detailed description: All participants were asked about perceived loss of urine, the effort or without apparent effort. The responses of participants from G1 were offered by parents and / or responsible.

Eligibility criteria: Inclusion Criteria:

* nulliparous and nulligest women

Exclusion Criteria:

* women with cancer reported
* surgeries of the inferior urinary treatment
* urinary infection
* cognitive alterations
* pregnant
* obesity

Primary outcomes:
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
affiliation: Universidade de Franca
name: Lislei Patrizzi
role: STUDY_DIRECTOR
References:
Clinical trial NCT01443507: Effect of Exercise With Low Intensity and Longer Duration Versus High Intensity Interval Training
Official title: Does Endurance Exercise With Low Intensity and Longer Duration Improve Aerobic Capacity to the Same Extent as High Intensity Interval Training?
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE2
Conditions: Healthy Subjects
Keywords: aerobic capacity
maximal oxygen uptake
aerobic endurance
work economy
lactate threshold
endurance training
exercise intensity
Lead sponsor: Volda University College
Sponsor class: OTHER
Collaborators: name: helse Møre og Romsdal, Volda sjukehus
First posted: 2011-09-29
Enrollment: 22
Sex: ALL
Minimum age (years): 18
Maximum age (years): 30
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: FACTORIAL
Primary purpose: PREVENTION

Brief summary: The purpose of the study is to compare exercise at 70% of maximal heart rate were total energy expenditure is twice compared to interval training at 90- 95% of maximal heart rate. Since 70% of maximal heart rate is well above the minimum threshold for improvements in maximal oxygen uptake it should be suited to investigate the effect of duration.


Eligibility criteria: Inclusion Criteria:

* healthy non smoking men and woman, age 18-30

Exclusion Criteria:

* pathological findings measured by ekko/doppler, high cholesterol or high blood pressure

Primary outcomes:
measure: changes in maximal oxygen uptake
timeFrame: Maximal oxygen uptake will be measured at day 1 before training, then we will measure changes in maximal oxygen uptake after 8 weeks, and finally a follow up measurement of changes in maximal oxygen uptake after 1 year
Secondary outcomes:
measure: endurance performance
timeFrame: one year
measure: health effects
timeFrame: one year
Other outcomes:
Locations:
city: Volda
country: Norway
facility: Volda university college
Study officials:
affiliation: Volda University College
name: Aud Folkestad, dean
role: STUDY_DIRECTOR
References:
Clinical trial NCT04664907: Videomusic and Psychic Trauma
Official title: Phenomenological Crossing of the Psychic Trauma and Its Resolution. Imagination at the Heart of the Treatment: Video-music as a Metaphor for Psychological Trauma and Its Resolution.
Study type: INTERVENTIONAL
Overall status: WITHDRAWN
Phase: NA
Conditions: Post Traumatic Stress Disorder
Keywords: Psychic trauma
Phenomenology
Consciousness
Anxiety
Music
Videomusic
Lead sponsor: Centre Hospitalier Intercommunal de Toulon La Seyne sur Mer
Sponsor class: OTHER
First posted: 2020-12-11
Enrollment: 0
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: TREATMENT

Brief summary: This project is interested in the flow of consciousness and its modalizations during psychological trauma (post-traumatic stress disorder) and its resolution. It is based on the premise that in PTSD, consciousness becomes more rigid, less fluid, due to the memory always imposing itself on the consciousness. The resolution of the trauma and the subsequent reduction of anxiety might improve the fluidity of consciousness and thus lead to an overall improvement in the psychological state of PTSD patients. In cases of PTSD, music has been shown to reduce anxiety from the very first session and has a very positive effect on all PTSD symptoms.

In this project the following elements will be evaluated : on one hand, the changes in consciousness and its fluidity and, on the other hand, the evolution of anxiety following the listening of a new kind of work, videomusic (which associates a video scenario with music) exemplifying (metaphorizing) the trauma and its resolution.


Eligibility criteria: Inclusion Criteria:

* Male or female at least 18 years of age
* Patients diagnosed with Simple Post Traumatic Stress according to DSM 5 criteria
* Patient able to express consent prior to participation in the study
* Patient affiliated to or beneficiary of a social security regimen

Exclusion Criteria:

* Other serious psychiatric pathologies
* Serious chronic pathologies, especially neurological ones
* Epilepsy
* Blindness or deafness
* Psychiatric decompensation
* Pregnant Women
* Patient under judicial protection (guardianship, curatorship...) or justice safeguard
* Any other reason that, in the opinion of the investigator, could interfere with study objective evaluation

Primary outcomes:
measure: Consciousness fluidity using a questionnaire dedicated to this measure
timeFrame: 4 weeks
Secondary outcomes:
measure: Qualitative analysis of experiential phenomenological interview
timeFrame: 4 weeks
measure: Salience-resonances method
timeFrame: 4 weeks
measure: Patient anxiety
timeFrame: 4 weeks
measure: Post traumatic stress disorder phenomenological definition
timeFrame: 4 weeks
Other outcomes:
Locations:
Study officials:
affiliation: Centre Hospitalier Intercommunal Toulon La Seyne sur Mer
name: Manuel Dias Alves, MD
role: STUDY_DIRECTOR
References:
Clinical trial NCT05288907: SOOTHER Trial to Treat Rectal Itch
Official title: SOOTHER Trial: Study of an Over-the-Counter Ointment to Treat Rectal Itch
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Pruritus Ani
Keywords: Pruritus ani
rectal itch
anal itch
Lead sponsor: Bell International Laboratories
Sponsor class: INDUSTRY
First posted: 2022-03-21
Enrollment: 20
Sex: ALL
Minimum age (years): 18
Maximum age (years): 80
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: CASE_ONLY
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Adult patients with pruritus ani (anal itch/discomfort)

Brief summary: Longitudinal, observational, single-arm trial of a novel, composite Lidocaine ointment to treat rectal itch (pruritus ani)


Eligibility criteria: Inclusion Criteria:

* Presence of pruritus ani (anal itch/discomfort) for at least 2 weeks, and a compatible physical exam.

Exclusion Criteria:

* Inability to understand informed consent, history of inflammatory bowel disease, known venereal disease, or immunodeficiency disease, history of or current anal or perianal abscess, anal or rectal surgery within the past 12 weeks, pregnancy or breastfeeding female, or signs of other rectal diseases such as anorectal fistula, infection, perianal eczema or tumors.

Primary outcomes:
measure: Symptom assessment
timeFrame: 2 weeks
measure: Visual ano-rectal exam
timeFrame: 2 weeks
Secondary outcomes:
Other outcomes:
Locations:
city: Plymouth
country: United States
facility: Minnesota Gastroenterology
state: Minnesota
Study officials:
affiliation: Bell International Laboratories
name: Mohammad Saremi
role: PRINCIPAL_INVESTIGATOR
References:
citation: Felemovicius I, Ganz RA, Saremi M, Christopfel W. SOOTHER TRIAL: Observational study of an over-the-counter ointment to heal anal itch. Front Med (Lausanne). 2022 Sep 14;9:890883. doi: 10.3389/fmed.2022.890883. eCollection 2022.
Clinical trial NCT03331107: Correlation of the Objective and Subjective Measures of the Nasal Obstruction Before and After Surgery of the Nasal Septum
Official title: Correlation of the Objective and Subjective Measures of the Nasal Obstruction Before and After Surgery of the Nasal Septum
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Nasal Obstruction
Lead sponsor: Fondation Hôpital Saint-Joseph
Sponsor class: OTHER
First posted: 2017-11-06
Enrollment: 80
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: patient admitted for septoplasty in Institut Arthur Vernes

Brief summary: Nasal obstruction is a very subjective sensation but it's also a frequent reason of consultation. Two specific questionnaire NOSE and RhinoQOL were validated; but rhinomanometry value is still a question to debate. As well as the difference between acoustic rhinometry and rhinomanometry.

Usually nasal obstruction due to a septal deviation is treated by septoplasty. If the anatomic result can be proved true, the patient's felt would be unsuccessful.

The aim of this study is to assess the impact of septoplasty on the nasal obstruction, objectively by rhinometry and subjectively by questionnaire.


Eligibility criteria: Inclusion Criteria:

* age \>18
* with medical insurance
* programmed for septoplasty
* nasal obstruction with septal deviation
* accept participation

Exclusion Criteria:

* nasal sine polyposis
* endonasal mass
* chronic sinusite
* previous nasal surgery

Primary outcomes:
measure: Nose Obstruction symptom Evaluation
timeFrame: 3 months
measure: nasal resistance to airflow
timeFrame: 3 months
Secondary outcomes:
Other outcomes:
Locations:
city: Paris
country: France
facility: Groupe Hospitalier Paris Saint Joseph
state: Ile-de-France
Study officials:
References:
Clinical trial NCT00139607: Parecoxib In Post Surgery (Hemicolectomy) Pain
Official title: A Multicenter, Open Label, Pilot Study To Evaluate Analgesic Activity And Safety Of Parecoxib 40 Mg IV In Patients Undergoing Hemicolectomy, In The Optimal Management Of Acute Post-Operative Pain Of Surgical Patients
Study type: INTERVENTIONAL
Overall status: TERMINATED
Phase: PHASE3
Conditions: Colectomy
Lead sponsor: Pfizer
Sponsor class: INDUSTRY
First posted: 2005-08-31
Enrollment: 60
Sex: ALL
Minimum age (years): 18
Maximum age (years): 80
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NON_RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: This is a phase III, multicenter, open label, pilot to evaluate the analgesic efficacy and safety of parecoxib 40 mg IV in the treatment of the pain following hemicolectomy in an optimal management of the surgical patient

Detailed description: The study was terminated prematurely due to recruitment issues on 31 January 2006. Safety concerns did not lead to the decision to terminate this study.

Eligibility criteria: Inclusion Criteria:

* patients hospitalised for resection of left/right colon;
* preoperative health graded as ASA \<3.

Exclusion Criteria:

* patients with any type of metastatic cancer, particularly metastatic colon cancer;
* patients with familial adenomatous polyps (sporadic adenomatous polyps are accepted);

Primary outcomes:
measure: Evaluation of efficacy assessments based on pain intensity (VAS) and on Pain relief (PR).
Secondary outcomes:
measure: Time between the first administration of parecoxib and the first request of morphine The total amount of morphine in the first 24 hours of treatment and the total amount of morphine given during the entire period of treatment with parecoxib
Other outcomes:
Locations:
city: Biella
country: Italy
facility: Pfizer Investigational Site
city: Milano
country: Italy
facility: Pfizer Investigational Site
city: Siena
country: Italy
facility: Pfizer Investigational Site
Study officials:
affiliation: Pfizer
name: Pfizer CT.gov Call Center
role: STUDY_DIRECTOR
References: