Clinical trial NCT02514109: Clinical, Electrophysiological and Biological Diagnostic Criteria of Sensory Neuronopathies
Official title: Clinical, Electrophysiological and Biological Diagnostic Criteria of Sensory Neuronopathies
Study type: OBSERVATIONAL
Overall status: TERMINATED
Conditions: Neuronopathy
Keywords: neuronopathy
antibodies
Clinical and biological diagnostic criteria
Lead sponsor: Centre Hospitalier Universitaire de Saint Etienne
Sponsor class: OTHER
First posted: 2015-08-03
Enrollment: 80
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: CASE_CONTROL
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Patient group : patient with sensitive neuronopathy Control group :patient without sensitive neuronopathy

Brief summary: The diagnosis of sensory neuronopathy is difficult to establish because the only certainty criterion is based on the detection of specific lesions in the posterior spinal ganglion which is usually not possible. There is to date no clinical and electrophysiological criteria or validated biomarker for the diagnosis of this type of neuropathy. In a retrospective study, we analyzed the files of patients with peripheral sensory neuronopathy certain and established clinical and electrophysiological diagnostic criteria for sensitive neuronopathy. We therefore wish now validate these criteria and investigate possible associated antibodies on a prospective cohort of patients.

Detailed description: All the patients (patient group and control) will be included in the study after giving their consent. The clinical, biological and electrophysiological data concerning the neuropathy will be collected. There is no specific follow-up for the study.

Blood samples will be retrospectively analyzed for antibody screening.

Eligibility criteria: Inclusion Criteria:

* A :Patients Male or female patient aged 18 years or more with a clinically pure sensory neuropathy, abnormal ENMG in sensory nerves in more than one limb and complete etiological assessment allowing a diagnosis of sensory neuronopathy.

B :Controls Male or female patient aged 18 years or more with a clinically pure sensory neuropathy, abnormal ENMG in sensory nerves in more than one limb and complete etiological assessment allowing a diagnosis of sensory neuropathy excluding a neuronopathy.

Exclusion Criteria:

* Patient with a sensory-motor neuropathy or incomplete clinical evaluation

Primary outcomes:
measure: Likelihood ratio diagnostic criteria established on the study population
timeFrame: baseline
Secondary outcomes:
measure: Identified antibodies
timeFrame: baseline
Other outcomes:
Locations:
city: Angers
country: France
facility: CHU Angers
city: Clermont-Ferrand
country: France
facility: CHU Clermont-Ferrand
city: Grenoble
country: France
facility: CHU de Grenoble
city: Lyon
country: France
facility: Hospices Civils de Lyon
city: Marseille
country: France
facility: AP-HM
city: Montpellier
country: France
facility: CHU de Montpellier
city: Nimes
country: France
facility: CHU de Nimes
city: Paris
country: France
facility: Hopital Pitie Salpetriere
city: Poitiers
country: France
facility: CHU Poitiers
city: Saint-etienne
country: France
facility: Chu Saint-Etienne
city: Strasbourg
country: France
facility: Chu Strasbourg
city: Tours
country: France
facility: Chu de Tours
Study officials:
affiliation: CHU SAINT-ETIENNE
name: Jean-Christophe ANTOINE, PhD
role: PRINCIPAL_INVESTIGATOR
References: