Clinical trial NCT04978246: Cognitive Functions After COVID-19
Official title: Evaluation Of Cognitive Functions In Adult Individuals With COVID-19
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: COVID-19 Acute Respiratory Distress Syndrome
Cognitive Decline
Keywords: Cognitive Functions
COVID-19
Attention
Executive Functions
Memory
Neurophysiology
Lead sponsor: Medipol University
Sponsor class: OTHER
First posted: 2021-07-27
Enrollment: 100
Sex: ALL
Minimum age (years): 18
Maximum age (years): 50
Standard ages: ADULT
Accepts healthy volunteers: yes
Observational model: CASE_CONTROL
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Community sample

Brief summary: This study was aimed to evaluate the post-infection cognitive functions of adult individuals with COVID-19. 50 individuals with COVID-19 and 50 healthy control groups were included in the study. Cognitive functions of individuals with COVID19 compared with healthy individuals.

Detailed description: This study was aimed to evaluate the post-infection cognitive functions of adult individuals with COVID-19. Fifty COVID-19 patients, aged between 18-50 years, who had positive RT-PCR test in the last 60 days and later recovered, were included in the study. The study group was compared with the control group consisting of 50 healthy individuals in whom gender, age and education year has not difference significantly. Participants' global cognitive skills were measured by the Montreal Cognitive Assessment Test (MoCA), the Clock Drawing Test and memory functions, the Öktem Verbal Memory Processes Test (Ö-SBST), the attention functions by the Digit Span Forward and Digit Span Backwards Test, the executive functions by Categorical Fluency, Phonemic Fluency, the Stroop Test, Trail Making Test A and B, visuospatial skills were evaluated with the Rey-Osterrieth Complex Figure Test (ROCF), and behavioral symptoms were evaluated with the Neuropsychiatric Inventory (NPI). The study group was evaluated between 21 and 60 days from the onset of the disease.

Eligibility criteria: Inclusion Criteria:

* Having positive for the COVID-19 RT-PCR test and turned negative in the last 60 days.
* be 18-50 years old
* 21 days have passed since the onset of the disease

Exclusion Criteria:

* Having any neurological or psychiatric illness

Primary outcomes:
measure: Montreal Cognitive Assessment Test (MoCA)
timeFrame: Any day between 21-60 days from the date of COVID-10 RT-PCR test positive.
Secondary outcomes:
measure: Clock Drawing Test
timeFrame: Any day between 21-60 days from the date of COVID-10 RT-PCR test positive.
measure: Öktem Verbal Memory Processes Test (Ö-SBST)
timeFrame: Any day between 21-60 days from the date of COVID-10 RT-PCR test positive.
measure: Digit Span
timeFrame: Any day between 21-60 days from the date of COVID-10 RT-PCR test positive.
measure: Verbal Fluency Test
timeFrame: Any day between 21-60 days from the date of COVID-10 RT-PCR test positive.
measure: Stroop Test
timeFrame: Any day between 21-60 days from the date of COVID-10 RT-PCR test positive.
measure: Trail Making Test
timeFrame: Any day between 21-60 days from the date of COVID-10 RT-PCR test positive.
measure: Rey-Osterrieth Complex Figure Test (ROCF)
timeFrame: Any day between 21-60 days from the date of COVID-10 RT-PCR test positive.
measure: Neuropsychiatric Inventory (NPI)
timeFrame: Any day between 21-60 days from the date of COVID-10 RT-PCR test positive.
Other outcomes:
Locations:
city: Beykoz
country: Turkey
facility: Istanbul Medipol University
state: İstanbul
Study officials:
affiliation: Medipol University
name: Büşra Tüfekçi, MD
role: PRINCIPAL_INVESTIGATOR
References:
citation: Zhou H, Lu S, Chen J, Wei N, Wang D, Lyu H, Shi C, Hu S. The landscape of cognitive function in recovered COVID-19 patients. J Psychiatr Res. 2020 Oct;129:98-102. doi: 10.1016/j.jpsychires.2020.06.022. Epub 2020 Jun 30.