Clinical trial NCT03879980: Effect of Quadratus Lumborum Block on Perioperative Analgesia and Inflammatory Responses in Laparoscopic Nephrectomy
Official title: Effect of Preincisional Ultrasound-guided Quadratus Lumborum Block on Perioperative Analgesia and Inflammatory Responses in Transperitoneal Laparoscopic Nephrectomy: A Single-Blinded, Randomised Control Trial
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Postoperative Pain
Keywords: quadratus lumborum block
pre-emptive analgesia
laparoscopic nephrectomy
Lead sponsor: Indonesia University
Sponsor class: OTHER
First posted: 2019-03-19
Enrollment: 44
Sex: ALL
Minimum age (years): 18
Maximum age (years): 65
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: SUPPORTIVE_CARE

Brief summary: Quadratus lumborum (QL) block can reduce intraoperative opioid consumption, decrease inflammation responses of IL-6, and reduce acute pain intensity in comparison with non-receiving QL block as the control group.

Detailed description: Quadratus lumborum block had been studied as an effective postoperative analgesia in lower abdominal surgery, due to its spread to the thoracic paravertebral space and thoracolumbar fascia nerve. The effect of preincisional ultrasound (US)-guided QL block as "preemptive analgesia" on patient underwent laparoscopic living donor nephrectomy has never been evaluated. As preemptive analgesia, quadratus lumborum block could provide analgesics before and after surgery. Both groups immediately received basic postoperative analgesia regimen paracetamol 1 gr IV 8th hourly.

Eligibility criteria: Inclusion Criteria:

* BMI \< 30 kg/m2
* ASA 1 or 2

Exclusion Criteria:

* refused to participate
* chronic use of analgesics or anti-inflammatory drugs
* allergy to local anaesthetic
* duration of surgery \<4 or \> 6 hours
* duration of anaesthesia \<5 or \> 7 hours
* neuropathy

Primary outcomes:
measure: Intraoperative fentanyl consumption
timeFrame: Intraoperative
measure: Changes in Interleukin-6 from baseline
timeFrame: 24 hours
Secondary outcomes:
measure: Numerical Rating Scale
timeFrame: 24 hours
measure: Hemodynamic Profiles: Heart Rate in bpm
timeFrame: Intraoperative
measure: Hemodynamic Profiles: Systolic, Diastolic, and Mean Arterial Pressure in mmHg
timeFrame: Intraoperative
measure: Number of participants with additional intravenous tramadol
timeFrame: 24 hours
measure: Number of participants with additional intravenous fentanyl
timeFrame: 24 hours
Other outcomes:
Locations:
city: Jakarta Pusat
country: Indonesia
facility: Rumah Sakit Cipto Mangunkusumo
state: DKI Jakarta
Study officials:
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