louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT06230809: Internet Based Self-help for Problem Gambling Concerned Significant Others
Official title: Internet Based Self-help for Problem Gambling Concerned Significant Others
Study type: INTERVENTIONAL
Overall status: NOT_YET_RECRUITING
Phase: NA
Conditions: Problem Gambling
Keywords: concerned significant others
Lead sponsor: Karolinska Institutet
Sponsor class: OTHER
Collaborators: name: The National Gambling Helpline Sweden
First posted: 2024-01-30
Enrollment: 170
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: SUPPORTIVE_CARE

Brief summary: The project aims to evaluate a brief online self-help intervention for Concerned Significant Others of individuals with Problem Gambling. The intervention consists of five modules with texts, films and exercises and is compared to a waiting list.


Eligibility criteria: Inclusion Criteria:

* No treatment related to the gambling during the past 3 months for the CSO
* The CSO is at least 18 years old
* The CSO can read and answer questions in Swedish.
* The CSO is assessed as a non-problem gambler according to the Gambling Disorder Identification Test.

Exclusion Criteria:

* Displaying symptoms of severe psychiatric disorders such as psychosis or bipolar disease deemed to needed other treatment options.

Primary outcomes:
measure: Kessler-9
timeFrame: At baseline and post treatment (5-7 weeks after inclusion) and again 3, 6, and 12 months following treatment completion
Secondary outcomes:
measure: Patient Health Questionnaire-9
timeFrame: At baseline and post treatment (5-7 weeks after baseline) and again 3, 6, and 12 months following treatment completion
measure: Generalized Anxiety Disorder 7-item scale
timeFrame: At baseline and post treatment (5-7 weeks after inclusion), and again 3, 6, and 12 months following treatment completion
measure: Relationship Assessment Scale
timeFrame: At baseline and post treatment (5-7 weeks after inclusion), and again 3, 6, and 12 months following treatment completion
measure: Family Member Impact Scale
timeFrame: At baseline and post treatment (5-7 weeks after inclusion), and again 3, 6, and 12 months following treatment completion
measure: Coping Questionnaire
timeFrame: At baseline and post treatment (5-7 weeks after inclusion), and again 3, 6, and 12 months following treatment completion
measure: Brunnsviken Brief Quality of life quality scale
timeFrame: At baseline and post treatment (5-7 weeks after inclusion), and again 3, 6, and 12 months following treatment completion
Other outcomes:
Locations:
Study officials:
References:
Clinical trial NCT04360109: Study of the Association Between Presbycusis With the Incidence of Frailty
Official title: Study of the Association Between Presbycusis With the Incidence of Frailty. Intake of Polyphenols for the Prevention of Presbycusis: Effects on Frailty
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Presbycusis
Frailty Syndrome
Oxidative Stress
Lead sponsor: Universidad Europea de Madrid
Sponsor class: OTHER
First posted: 2020-04-24
Enrollment: 300
Sex: ALL
Minimum age (years): 60
Maximum age (years): 99
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: People who meet the inclusion and exclusion criteria and who attend the ENT or geriatrics clinic

Brief summary: The objective of the project is to establish the association between presbycusis and the incidence of frailty in humans in order to establish hearing loss with age as another index for the diagnosis of frailty; As well as studying the effect of exposure to polyphenols in the diet on presbycusis and frailty. Human study: volunteers between 60 and 99 years old, men and women during a period of 6 months, questions and answers, audiometries, study of fragility, analysis of antioxidants in blood, and samples of urine will be measured Total polyphenols and oxidant capacity.


Eligibility criteria: Inclusion Criteria:

* Age

Exclusion Criteria:

* Disease of the hearing system
* Serious illness (e.g. tumor)
* Dementia
* Total dependence

Primary outcomes:
measure: Auditory function
timeFrame: 6 months
measure: Frailty
timeFrame: 6 months
Secondary outcomes:
measure: Determination of total polyphenols in urine
timeFrame: measured twice in each volunteer, at the beginning and end of the study period (6 months)
measure: Blood analysis,
timeFrame: It will be performed at the beginning and at end of the study period (6 months)
measure: Microbiota
timeFrame: It will be performed at the beginning and at end of the study period (6 months)
Other outcomes:
Locations:
city: Getafe
country: Spain
facility: Hospital Universitario de Getafe
state: Madrid
Study officials:
affiliation: Universidad Europea de Madrid
name: Carolina S Rodríguez
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT02299609: Ultrasound Beams as an Adjunct to Reperfusion Therapy in STEMI
Official title: Therapeutic Effect of Ultrasound Beams as an Adjunct to Reperfusion Therapy in STEMI
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Myocardial Infarction
ST Elevation Myocardial Infarction
Keywords: C14.280.647.500
Lead sponsor: Sakarya University
Sponsor class: OTHER
First posted: 2014-11-24
Enrollment: 100
Sex: ALL
Minimum age (years): 18
Maximum age (years): 80
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: SUPPORTIVE_CARE

Brief summary: Successfully perfused STEMI patients will receive routine transthoracic echocardiography qid for 4 days or placebo. Myocardial function and infarct size will be evaluated at 3 and 6 months.

Detailed description: Patients who had acute STEMI and successfully reperfused by either thrombolytic therapy or primary angioplasty and stenting will be included this study.

A basal routine echocardiography will be obtained in all patients after reperfusion therapy. Thereafter, patients will be divided into two groups: 1.Treatment group will receive transthoracic echocardiography using Philips HD11 XE ® for 30 minutes qid for 4 days. 2. Placebo group will have the same Philips HD11 XE ® echo transducer applied for the same time and duration on their chest but with the ultrasound turned-off. Detailed left and right ventricle function as well as performance index and stress-strain imaging will be obtained and analyzed at 3 and 6 months.

Eligibility criteria: Inclusion criteria:

-Patients presenting within 12 hours of their first ST- elevation myocardial infarction that is successfully reperfused; and completed baseline echocardiographic evaluation and accepted participation in the study

Exclusion criteria:

Patients:

* With prior ST- elevation myocardial infarction
* Patients presenting \>12hrs
* Not successfully reperfused
* Not completed baseline ECHO evaluation,
* Not accepting participation in the study

Primary outcomes:
measure: Increase in left ventricular function
timeFrame: At 3 and 6 months
Secondary outcomes:
measure: Decrease in infarct size
timeFrame: At 3 and 6 months
Other outcomes:
Locations:
city: Sakarya
country: Turkey
facility: Sakarya University, Faculty of Medicine
Study officials:
affiliation: Sakarya University
name: Ramazan Akdemir, MD
role: STUDY_CHAIR
References:
citation: Ling ZY, Shu SY, Zhong SG, Luo J, Su L, Liu ZZ, Lan XB, Yuan GB, Zheng YY, Ran HT, Wang ZG, Yin YH. Ultrasound targeted microbubble destruction promotes angiogenesis and heart function by inducing myocardial microenvironment change. Ultrasound Med Biol. 2013 Nov;39(11):2001-10. doi: 10.1016/j.ultrasmedbio.2013.06.003. Epub 2013 Aug 19.
citation: Nazer B, Gerstenfeld EP, Hata A, Crum LA, Matula TJ. Cardiovascular applications of therapeutic ultrasound. J Interv Card Electrophysiol. 2014 Apr;39(3):287-94. doi: 10.1007/s10840-013-9845-z. Epub 2013 Dec 3.
Clinical trial NCT00519909: The Effect of Calcium on Fecal Fat and Energy Excretion
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Obesity
Keywords: dairy products, calcium, fat excretion, energy excretion
Lead sponsor: University of Copenhagen
Sponsor class: OTHER
Collaborators: name: Arla Foods
name: The Danish Dairy Research Foundation, Denmark
name: FOOD Graduate School, the Royal Veterinary & Agricultural University, Denmark
name: Danish Research Agency
First posted: 2007-08-23
Enrollment: 15
Sex: MALE
Minimum age (years): 18
Maximum age (years): 50
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: CROSSOVER
Primary purpose: BASIC_SCIENCE

Brief summary: The overall purpose of this study is to examine the effect of calcium on fecal fat and energy excretion.

Detailed description: Several reports have found inverse associations between calcium intake and body weight. Few intervention studies have shown that a high calcium diet resulted in a greater body weight loss than a low calcium diet. The mechanism is not clear, but one possible explanation is reduced absorption of fat in the gut, due to formation of insoluble calcium fatty acid soaps or binding of bile acids which impairs the formation of micelles.

The aim of this study is to examined if a high calcium intake from dairy products, in diets high or normal in fat content, have an effect on fecal energy and fat excretion, concentrations of substrates involved in energy metabolism and blood pressure.

Eligibility criteria: Inclusion Criteria:

* healthy meals
* BMI 24-31 kg/m2
* age between 18-50 years

Exclusion Criteria:

* donation of blood 6 months before and under the study
* milk allergy, diabetes, hypertension, hyperlipidemia, cronic infectious disease
* use of dietary supplements 3 months before and under the study
* smoking
* elite athletes
* use of medication

Primary outcomes:
measure: Fecal fat excretion, fecal energy excretion, calcium excretion, cholesterol
Secondary outcomes:
measure: Vitamin D, changes in lipolyse
Other outcomes:
Locations:
city: Frederiksberg
country: Denmark
facility: Dept. of Human Nutrition, Faculty of Life Sciences, University of Copenhagen
Study officials:
affiliation: Dept. of Human Nutrition, Faculty of Life Sciences, Univerity of Copenhagen
name: Janne K Lorenzen, PhD student
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT05782309: Healthy Aging Through Dietary Intervention
Official title: Healthy Aging Through Dietary Intervention: Multiparametric Quantification of Function and Pathophysiology of the Aging Heart and Prevention of Age-associated Decline in Exercise Capacity Through Dietary Flavanols
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Aging, Healthy
Lead sponsor: Heinrich-Heine University, Duesseldorf
Sponsor class: OTHER
First posted: 2023-03-23
Enrollment: 68
Sex: ALL
Minimum age (years): 50
Maximum age (years): 79
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: PREVENTION

Brief summary: To test the impact of flavanol supplementation of cardiac and vascular function and subsequently on exercise capacity in elderly individuals


Eligibility criteria: Inclusion Criteria:

* age 50-79

Exclusion Criteria:

* non-cardiac limitations of exercise capacity such as orthopedic or neurological disorders, BMI \>35 kg/m2, active smoking, uncontrolled blood pressure, diabetes, COPD, atrial fibrillation, cardiomyopathy, coronary heart disease, valvular heart disease, cardiac pacemaker, acute respiratory tract infections, missing ability or missing cooperation to participate in the study

Primary outcomes:
measure: Exercise capacity
timeFrame: 30 days
measure: peakVO2
timeFrame: 30 days
Secondary outcomes:
measure: flow mediated vasodilation (FMD)
timeFrame: 30 days
measure: Oxygen pulse
timeFrame: 30 days
measure: aortic stiffness
timeFrame: 30 days
measure: diastolic strain
timeFrame: 30 days
measure: Left ventricular function
timeFrame: 30 days
measure: left atrial volume index (LAVi)
timeFrame: 30 days
measure: brain natriuretic peptide (nt-proBNP)
timeFrame: 30 days
measure: aortic pulse wave velocity (PWV)
timeFrame: 30 days
measure: diastolic strain rate (SR)
timeFrame: 30 days
Other outcomes:
Locations:
city: Düsseldorf
country: Germany
facility: Heinrich Heine University
state: NRW
Study officials:
References:
Clinical trial NCT02131909: PC MIROIR : Effects of Mirror Therapy in Children With Hemiplegic Cerebral Palsy
Official title: PC MIROIR : Effects of Mirror Therapy in Children With Hemiplegic Cerebral Palsy
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Hemiplegic Cerebral Palsy
Keywords: unilateral cerebral palsy
children
upper-limb
mirror therapy
bimanual coordination
kinematics analysis
Lead sponsor: Rennes University Hospital
Sponsor class: OTHER
First posted: 2014-05-06
Enrollment: 33
Sex: ALL
Minimum age (years): 7
Maximum age (years): 17
Standard ages: CHILD
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: OTHER

Brief summary: This is a randomized and comparative prospective test, monocentric and controlled (mirror therapy versus bimanual rehabilitation exercises), in single-blind (investigator and occupational therapist " 1 " do not know the type of rehabilitation performed).


Eligibility criteria: Inclusion Criteria:

* Unilateral spastic cerebral palsy as defined by SCPE (Surveillance of Cerebral Palsy in Europe)
* Aged 7 to 17 years
* MACS (Manual Ability Classification System) 1 to 3
* Extension of the wrist more than 10°
* Free, informed and written consent of the parents
* Free, informed and written consent of the child
* affiliated, via his/her parents, to the Social Security regime

Exclusion Criteria:

* Other neuromuscular disorders known
* Cognitive impairment hampering the understanding of instructions
* Upper-limb pain (EVA score \>3)
* Restriction of passive range of motion
* Visual impairment not allowing the visualization of the upper limb in the mirror
* Upper-limb Botulinum toxin injection in upper limb 6 months prior to inclusion

Primary outcomes:
measure: Measurement of the AHA (Assisting Hand Assessment) score
timeFrame: 5 weeks
Secondary outcomes:
measure: Evolution of the AHA score
timeFrame: baseline, 5 weeks, 10 weeks
measure: Measurement of the maximal grasp and pinch strength
timeFrame: baseline, 5 weeks, 10 weeks
measure: Qualitative and quantitative measurement of movement
timeFrame: baseline, 5 weeks, 10 weeks
measure: Measurement of the manual ability
timeFrame: baseline, 5 weeks, 10 weeks
Other outcomes:
Locations:
city: Rennes
country: France
facility: CHU Rennes
Study officials:
affiliation: CHU Rennes
name: Hélène HR Rauscent
role: PRINCIPAL_INVESTIGATOR
References:
citation: Gaillard F, Cretual A, Cordillet S, Le Cornec C, Gonthier C, Bouvier B, Heyman R, Marleix S, Bonan I, Rauscent H. Kinematic motion abnormalities and bimanual performance in children with unilateral cerebral palsy. Dev Med Child Neurol. 2018 Aug;60(8):839-845. doi: 10.1111/dmcn.13774. Epub 2018 Apr 27.
Clinical trial NCT00556309: Optical Coherence Tomography Imaging of Post Coil Aneurysm Healing.
Official title: Optical Coherence Tomography Imaging of Post Coil Aneurysm Healing.
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Cerebral Aneurysm
Lead sponsor: University of California, Irvine
Sponsor class: OTHER
Collaborators: name: Beckman Laser Institute University of California Irvine
First posted: 2007-11-09
Enrollment: 3
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: CASE_ONLY
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: Primary care clinic

Brief summary: The purpose of this study is to identify the healing of aneurysms in three month use Optical Coherence Tomography image to measure outcomes in post coiled aneurysms. Endovascular therapeutic coiling is a widely used procedure in the management of aneurysms, which is an angiogram .

Detailed description: Subarachnoid hemorrhage secondary to ruptured cerebral aneurysms, unruptured aneurysms that are being treated using endovascular coiling. The researcher can use Optical Coherence Tomography image at the rime of initial angiography with unruptured aneurysms, and at the three month follow up catheter angiogram.

Optical Coherence Tomography image can follow the therapeutic coiling of the aneurysm, the 6F endocatheter and the microcatheter used for the coiling procedure place in the internal carotid artery and parent artery lumen follow with Optical Coherence Tomography fiber insert through the lumen of the tube on which the image can obtain.

Eligibility criteria: Inclusion Criteria:

* Age ≥ 18 years of age
* Subject diagnosis of aneurysm and undergoing endovascular coiling

Exclusion Criteria:

* Pregnant women
* Age ≤ 18 years of age
* Patient presenting emergently with acutely ruptured aneurysms

Primary outcomes:
measure: Aneurysm Healing
timeFrame: up to 12 months
Secondary outcomes:
Other outcomes:
Locations:
city: Irvine
country: United States
facility: Beckman Laser Institute,University of California, Irvine
state: California
city: Irvine
country: United States
facility: Neurosurgery department, University of California,Irvine
state: California
Study officials:
affiliation: UCIMC
name: Marlon Mathew, MD
role: PRINCIPAL_INVESTIGATOR
affiliation: Zhongping Chen, PhD, Assistant Professor, Beckman Laser Institute
name: Zhongping Chen, PhD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT06965907: Kinesiotaping on Hand Function in Computer Users
Official title: Immediate Effect of Kinesio Taping on Two-Point Discrimination, Fine Motor Skills, Grip Strength and Reaction Time on Computer Users
Study type: INTERVENTIONAL
Overall status: RECRUITING
Phase: NA
Conditions: Computer-user Training
Keywords: kinesiotaping
sensation
dexterity
reaction time
athletic tape
Lead sponsor: Istinye University
Sponsor class: OTHER
First posted: 2025-05-11
Enrollment: 34
Sex: ALL
Minimum age (years): 18
Maximum age (years): 50
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: This study aims to investigate whether kinesio taping contributes to improved hand function in individuals who frequently use computers. The effectiveness of kinesio taping will be compared to sham taping in order to determine its impact. Participants will be randomly assigned to one of two groups: a kinesio taping group or a sham taping group. Taping will be applied to the forearm. Functional assessments will be conducted at three time points: prior to taping, immediately after taping, and 30 minutes post-taping. The following evaluations will be performed:

* Two-point discrimination test to assess touch sensitivity
* Purdue Pegboard test to evaluate fine motor skills
* Grip strength test using a hand dynamometer
* Visual reaction time test utilizing a light-based device All procedures will be completed in a single study session.


Eligibility criteria: Inclusion Criteria:

* Participants must use a computer ≥ 2 hours per day.
* Participants must be between the ages of 18 and 50.
* If the participants are employed, they must not have changed professions in the last 6 months.
* If the participants are students, their student status must have been ongoing for at least 6 months.

Exclusion Criteria:

* A diagnosed history of neuropathy or common diseases associated with peripheral neuropathy.
* Diagnosed musculoskeletal disorders related to the neck and upper extremities.
* Presence of symptoms suggestive of nerve entrapment.
* Having a condition that prevents the application of physical tests (e.g., limited range of joint motion, deformities, fractures, arthritis, etc.).
* Allergic reaction to kinesiology tape.

Primary outcomes:
measure: Two-point Discrimination
timeFrame: Day 1
measure: Fine Motor Skills
timeFrame: Day 1
measure: Grip Strength
timeFrame: Day 1
measure: Reaction Time
timeFrame: Day 1
Secondary outcomes:
Other outcomes:
Locations:
city: Istanbul
country: Turkey
facility: Istinye University Physiotherapy and Rehabilitation Application and Research Center (İSÜFİZYOTEM)
Study officials:
References:
Clinical trial NCT01625507: The Alberta Diet: Effectiveness Study
Official title: The Alberta Diet: a Proposal for Its Implementation
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE2
Conditions: Type 2 Diabetes
Lead sponsor: University of Alberta
Sponsor class: OTHER
First posted: 2012-06-21
Enrollment: 73
Sex: ALL
Minimum age (years): 35
Maximum age (years): 80
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: TREATMENT

Brief summary: The study hypothesis is that individuals with type 2 diabetes (T2D), who adhere to the PANDA intervention, will have improved compliance with the nutritional therapy recommendations of the Canadian Diabetes Association. Specific objectives of this proposal: The objectives of the investigators PANDA (Physical Activity and Nutrition for Diabetes in Alberta) are to (a) to devise and evaluate the efficacy of a multi-level, practical, nutrition intervention program that promotes the individual factors required for effective self-management practices AND that explicitly incorporate strategies to improve food availability, accessibility and acceptability and (b) to use these interventions as a means to examine the relationships between food availability, accessibility, acceptability, adherence to Nutrition Therapy Guidelines, and metabolic indicators of diabetes control in people with type 2 diabetes.


Eligibility criteria: Inclusion Criteria:

* Type 2 diabetes, and speak/write English.
* Have attended a diabetes education session delivered by their healthcare provider.

Exclusion Criteria:

* Participants with type 1 diabetes, and those who are unable to speak English.
* People with end-stage renal disease or gastrointestinal diseases that require specialized diets will also be excluded.

Primary outcomes:
measure: Change in Total Energy Intake
timeFrame: 4 months
measure: Change in Macronutrient Intake
timeFrame: 3 months
measure: Change in Nutrient Intake
timeFrame: 3 months
Secondary outcomes:
measure: Change in Hemoglobin A1c
timeFrame: 4 months
measure: Program Retention
timeFrame: 3 months
measure: Change in Body Mass Index
timeFrame: 4 months
measure: Body Composition
timeFrame: 3 months
measure: Change in Blood Biomarkers
timeFrame: 4 months
measure: Change in Perceived Dietary Adherence Questionnaire Score
timeFrame: 4 months
measure: Food Acceptability
timeFrame: 4 months
measure: Food Accessibility
timeFrame: 4 months
measure: Food Availability
timeFrame: 4 months
measure: Change in Waist Circumference
timeFrame: 4 months
Other outcomes:
Locations:
city: Edmonton
country: Canada
facility: Alberta Diabetes Institute
state: Alberta
Study officials:
affiliation: University of Alberta
name: Catherine B Chan, PhD
role: PRINCIPAL_INVESTIGATOR
References: