louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT01512732: Validation of the Hebrew Version of the Montreal Affective Voices.
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Parkinson's Disease
Depression
Lead sponsor: Hadassah Medical Organization
Sponsor class: OTHER
First posted: 2012-01-19
Enrollment: 120
Sex: ALL
Minimum age (years): 20
Maximum age (years): 70
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Sampling method: NON_PROBABILITY_SAMPLE
Study population: healthy group, Parkinson's disease patients, Major depressive disorder patients.

Brief summary: Today, no non-verbal auditory stimuli that assess mental processing are available in Israel. The goal of this study is to make available a validated set of auditory stimuli in Israel. We created a computerized Hebrew version of the Montreal Affective Voices (MAV). The MAV is a novel tool for assessing mental processing. The MAV consists of 90 nonverbal affect bursts corresponding to nine different emotions (such as anger, fear, happiness etc.) recorded by ten different actors. The uniqueness of these affective bursts is that they do not contain verbal context, but rather express affective moods using the vowel /a/ (as in "apple"). In this study, the investigators will verify the new Hebrew version of MAV in healthy control groups. Next, the investigators will compare the mental processing ability in young vs. old population, using the MAV test. In addition, the investigators will assess mental processing in two pathologic study groups (Parkinson's disease, major depressive disorder) using the MAV test. The investigators intend to use the MAV tool in future research in Parkinson's disease and depression.


Eligibility criteria: Inclusion Criteria:

* Healthy group
* Parkinson's disease
* Major depressive disorder
* All participants will be competent and willing to give written informed consent. Patients over 65 and/or suspected to have a cognitive decline will be tested by the Mini-mental test and will be included in the study only if the score is above 26.

Exclusion Criteria:

* Non-competent or unable to give written informed consent

Primary outcomes:
measure: Verifying the results achieved by Belin et al (2008) when using the Hebrew version of the MAV bursts in healthy control groups.
timeFrame: 12 months
Secondary outcomes:
Other outcomes:
Locations:
city: Jerusalem,
country: Israel
facility: Hadassah Medical Organization,
Study officials:
References:
Clinical trial NCT04097132: Pattern of Non Valvular Atrial Fibrillation in Acute Ischemic Stroke Patients at Assiut University Hospitals
Official title: Pattern of Non Valvular Atrial Fibrillation in Acute Ischemic Stroke Patients at Assiut University Hospitals
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Atrial Fibrillation
Lead sponsor: Assiut University
Sponsor class: OTHER
First posted: 2019-09-20
Enrollment: 1
Sex: ALL
Minimum age (years): 18
Maximum age (years): 90
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: The study will include all cases of acute cerebrovascular stroke in Assiut university hospital

Brief summary: Pattern of non valvular Atrial fibrillation in acute ischemic stroke patients at Assiut University Hospitals.

Detailed description: Percentage of patients with AF admitted with acute cerebrovascular stroke at Assuit University and correlation between AF and severity of stroke at admission and discharge.

Eligibility criteria: Inclusion Criteria:

* Patients presented with acute cerebrovascular stroke aged more than 18 years old.

Exclusion Criteria:

1. Patients below 18 years old.
2. Patient admitted with cerebral hemohrrage.
3. Patients with significant valvular heart disease.

Primary outcomes:
measure: Percentage of patients with AF admitted with acute cerebrovascular stroke at Assuit University.
timeFrame: 1 year
Secondary outcomes:
measure: correlation between AF and severity of stroke at admission and discharge.
timeFrame: 1 year
measure: The role of anti coagulants in decreasing risk of ischemic cerebrovascular stroke in patients who are known to have Atrial Fibrillation and have been already anticoagulated
timeFrame: 1 year
Other outcomes:
Locations:
city: Assiut
country: Egypt
facility: Shery Refaat Asaad
Study officials:
References:
Clinical trial NCT02391532: Effect of Probiotic Bacteria on Oral Candida in Frail Elderly
Official title: Effect of Probiotic Bacteria (L. Reuteri) on Oral Candida Counts in Frail Elderly
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Candidiasis
Lead sponsor: University of Copenhagen
Sponsor class: OTHER
First posted: 2015-03-18
Enrollment: 215
Sex: ALL
Minimum age (years): 60
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: PREVENTION

Brief summary: The aim of this study is to investigate the effect of daily intake of the probiotic Lactobacillus Reuteri on the prevalence and counts of oral Candida in frail elderly living in nursery homes.

Detailed description: The aim of the present study was to investigate the effect of a twice daily intake of lozenges containing probiotic Lactobacillus reuteri on the prevalence and counts of oral Candida in senior residents living in nursery homes. The material consists of 215 elderly persons (range 60 to 102 years) living in 20 different nursery homes in the County of Kronoberg, situated in the southern parts of Sweden. The subjects were consecutively enrolled after informed consent consisting of verbal and written information directed to the individual as well as to their relatives. The study employed a double-blind randomized placebo-controlled design.

Eligibility criteria: Inclusion Criteria:

* non-smoking
* ability to cooperate with a dental examination and saliva sampling

Exclusion Criteria:

* severe chronic disease, malignancies or ongoing medication with immunosuppressive drugs
* severe dementia or cognitive impairment

Primary outcomes:
measure: Prevalence of oral Candida growth assessed from chair-side tests.
timeFrame: Baseline and 12 weeks.
measure: Amount of oral Candida growth assessed from chair-side tests.
timeFrame: Baseline and 12 weeks.
Secondary outcomes:
measure: Change in levels of dental plaque
timeFrame: Baseline and 12 weeks.
measure: Changes in levels of gingival bleeding.
timeFrame: Baseline and 12 weeks.
Other outcomes:
Locations:
Study officials:
affiliation: University of Copenhagen
name: Svante Twetman, Professor
role: STUDY_DIRECTOR
References:
citation: Kraft-Bodi E, Jorgensen MR, Keller MK, Kragelund C, Twetman S. Effect of Probiotic Bacteria on Oral Candida in Frail Elderly. J Dent Res. 2015 Sep;94(9 Suppl):181S-6S. doi: 10.1177/0022034515595950. Epub 2015 Jul 22.
Clinical trial NCT03943732: Trial Measuring the Clinical Impact of the FilmArray® Pneumonia Panel in Critically Ill
Official title: Randomized Trial Measuring the Clinical Impact of the FilmArray® Pneumonia, a Prospective Interventional Trial
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Pneumonia
Keywords: Pneumonia
Molecular Testing
Clinical impact
FilmArray Pneumonia
Lead sponsor: Cliniques universitaires Saint-Luc- Université Catholique de Louvain
Sponsor class: OTHER
Collaborators: name: BioMérieux
First posted: 2019-05-09
Enrollment: 300
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: SEQUENTIAL
Intervention model description: Open Randomized study, consecutive 2 weeks-period for observation group and study group
Primary purpose: DIAGNOSTIC

Brief summary: The objective of this study is to measure how the use of Film-Array Pneumonia (FA-PNEU) on respiratory samples of adult patients suspected of acute care pneumonia in the intensive care unit of Saint-Luc University Hospital can accelerate / improve the initiation of the optimal antibiotic treatment.

Detailed description: The main objective of this trial is to confirm/attest/prove the following statement:

The use of the FilmArray Pneumonia panel on respiratory samples of critically ill suspected with pneumonia, enables a faster microbiological pneumonia diagnosis and an improved therapeutic management of the patient.

Eligibility criteria: Inclusion Criteria:

* Adult patients 18 years, remaining at the intensive care of the Saint-Luc University Hospital
* Recently transferred from emergency care with Community acquired Pneumonia of grade 4 suspicion
* With a Ventilation acquired Pneumonia suspicion

Suspicion will be based on symptoms, clinical, biological and radiological criteria.

Exclusion Criteria:

* Patients from whom no respiratory sample can be obtained
* Patients benefitting from palliative care
* Insufficient volume of the respiratory sample after routine testing to perform the FA-PNEU test.

Primary outcomes:
measure: Turn Around Time Treatment
timeFrame: 48 hours from arrival of the respiratory sample at the laboratory
Secondary outcomes:
measure: Performances FilmArray Pneumonia
timeFrame: 1 week from arrival of the respiratory sample at the laboratory
Other outcomes:
Locations:
city: Bruxelles
country: Belgium
facility: Cliniques Universitaires Saint-Luc
Study officials:
affiliation: Cliniques universitaires St-Luc
name: Alexia VERROKEN
role: PRINCIPAL_INVESTIGATOR
References:
citation: Kerneis S, Visseaux B, Armand-Lefevre L, Timsit JF. Molecular diagnostic methods for pneumonia: how can they be applied in practice? Curr Opin Infect Dis. 2021 Apr 1;34(2):118-125. doi: 10.1097/QCO.0000000000000713.
Clinical trial NCT01980732: 68Ga DOTA-TATE PET/CT in Somatostatin Receptor Positive Tumors
Official title: 68Ga DOTA-TATE PET/CT in the Evaluation of Patients With Somatostatin Receptor Positive Tumors
Study type: EXPANDED_ACCESS
Overall status: NO_LONGER_AVAILABLE
Conditions: Carcinoid Tumors
Islet Cell (Pancreatic NET)
Other Neuroendocrine Tumors
Lead sponsor: Stanford University
Sponsor class: OTHER
First posted: 2013-11-11
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no

Brief summary: The primary objective of the study is to evaluate 68Ga-DOTA TATE PET/CT for staging and monitoring response to chemotherapy in patients with carcinoid, neuroendocrine tumors, medullary thyroid cancer and other cancers expressing somatostatin receptors.


Eligibility criteria: Inclusion Criteria:

* Greater than 18 years-old at the time of radiotracer administration
* Provides written informed consent
* Known diagnosis of NET or suspected SSTR positive tumors by 111In-Octreotide scan, 18FDG-PET, or MRI of the abdomen when clinically indicated
* Karnofsky score greater than 50 or ECOG Performance Status 0-2
* Women of childbearing age must have a negative pregnancy test at screening/baseline
* Able to remain still for duration of each imaging procedure (about one hour)

Exclusion Criteria:

* Less than 18 years-old at the time of radiotracer administration
* Pregnant or nursing
* Serum creatinine \>3.0 mg/dL
* Hepatic enzyme levels more than 5 times upper limit of normal.
* Use of any other investigational product or device within 30 days prior to dosing, or known requirement for any other investigational agent prior to completion of all scheduled study assessments.
* Inability to lie still for the entire imaging time
* Inability to complete the needed investigational and standard-of-care imaging examinations due to other reasons (severe claustrophobia, radiation phobia, etc.)
* Any additional medical condition, serious intercurrent illness, or other extenuating circumstance that, in the opinion of the Investigator, may significantly interfere with study compliance.

Primary outcomes:
Secondary outcomes:
Other outcomes:
Locations:
city: Stanford
country: United States
facility: Stanford University, School of Medicine
state: California
Study officials:
affiliation: Stanford University
name: Andrei Iagaru
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT06554132: Respiratory Muscle Strength and Aerobic Capacity in Scleroderma
Official title: Investigation of Respiratory Muscle Strength and Aerobic Capacity in Patients With Scleroderma
Study type: OBSERVATIONAL
Overall status: RECRUITING
Conditions: Scleroderma
Keywords: Scleroderma
Respiratory muscle strength
Aerobic capacity
Lead sponsor: Firat University
Sponsor class: OTHER
First posted: 2024-08-15
Enrollment: 15
Sex: FEMALE
Minimum age (years): 18
Maximum age (years): 65
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: OTHER
Time perspective: CROSS_SECTIONAL
Sampling method: PROBABILITY_SAMPLE
Study population: People who have not a chronic disease or othopedic disease will be included as Healthy controls

Brief summary: Primary aim of this study was to compare respiratory muscle strength, aerobic capacity, dyspnea, pulmonary function tests and fatigue values with healthy controls. The secondary aim was to evaluate the relationship between respiratory muscle strength and other parameters in these patients and to examine the factors that may affect respiratory muscle strength. Respiratory muscle strength, aerobic capacity, respiratory function tests and fatigue will be evaluated

Detailed description: Scleroderma is a systemic connective tissue disease characterized by progressive thickening of the skin, the etiology of which has not been fully elucidated, in which microvascular damage, immune activation and fibrosis play a role. Primary aim of this study was to compare respiratory muscle strength, aerobic capacity, dyspnea, pulmonary function tests and fatigue values with healthy controls. The secondary aim was to evaluate the relationship between respiratory muscle strength and other parameters in these patients and to examine the factors that may affect respiratory muscle strength. The study will include 15 patients and 15 healthy individuals of the same age and gender. Respiratory muscle strength, aerobic capacity, respiratory function tests and fatigue will be evaluated

Eligibility criteria: Inclusion Criteria:

* Being diagnosed with Ssk according to ACR/EULAR criteria
* Stable medical treatment for 3 months

Exclusion Criteria:

* Having a regular exercise habit (doing regular exercise at least once a week for the last 3 months)
* Comorbidity with another chronic disease that may affect aerobic capacity or respiratory muscle strength
* Having concomitant acute respiratory diseases
* Having a smoking habit
* History of orthopedic or neurologic disease in the lower extremities that may prevent cycling

Primary outcomes:
measure: Respiratory muscle strength assessment
timeFrame: 5 minutes
Secondary outcomes:
measure: Aerobic capacity assessment
timeFrame: 10 minutes
measure: Fatigue assessment
timeFrame: 2 minutes
measure: Pulmonary function test
timeFrame: 5 minutes
Other outcomes:
Locations:
city: Elazığ
country: Turkey
facility: Songul Baglan Yentur
Study officials:
References:
Clinical trial NCT06597032: The Resilience Challenge: Fostering Emotional Resilience During a Time of National Stress
Official title: The Resilience Challenge: FERN (Fostering Emotional Resilience During a Time of National Stress)
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Stress
Positive Affect
Keywords: Positive Affect
Resilience Challenge
Positive Psychology
Stress
Lead sponsor: Northwestern University
Sponsor class: OTHER
First posted: 2024-09-19
Enrollment: 11659
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: SUPPORTIVE_CARE

Brief summary: The goal of this clinical trial is to examine the effects of an online positive psychological intervention on positive emotion, anxiety, depression, feelings of social isolation, sleep disturbance and a sense of meaning and purpose in the general public. The main question it aims to answer is:

Will the practice of positive emotion skills via a self-guided online platform reduce feelings of anxiety, depression, social isolation, and sleep disturbance, as well as increase well-being, positive emotion, a sense of meaning and purpose, life satisfaction, and general self-efficacy?

Participants will take part in an online positive psychological skill learning intervention for 6-8 weeks. Prior to beginning, immediately after, and 4 weeks after, participants will fill out measures of their wellbeing.


Eligibility criteria: Inclusion Criteria:

* Over 18 years old, Access to device connected to the internet

Exclusion Criteria:

* Under 18 years old

Primary outcomes:
measure: PROMIS Positive Affect CAT
timeFrame: At baseline, after completion of 6-8 week intervention, and 4 weeks later
Secondary outcomes:
measure: PROMIS Depression CAT
timeFrame: At baseline, after completion of 6-8 week intervention, and 4 weeks later
measure: PROMIS Anxiety CAT
timeFrame: At baseline, after completion of 6-8 week intervention, and 4 weeks later
measure: PROMIS Meaning and Purpose CAT
timeFrame: At baseline, after completion of 6-8 week intervention, and 4 weeks later
measure: PROMIS Social Isolation CAT
timeFrame: At baseline, after completion of 6-8 week intervention, and 4 weeks later
measure: PROMIS Sleep Disturbance CAT
timeFrame: At baseline, after completion of 6-8 week intervention, and 4 weeks later
measure: PROMIS General Self-Efficacy CAT
timeFrame: At baseline, after completion of 6-8 week intervention, and 4 weeks later
measure: PROMIS General Life Satisfaction CAT
timeFrame: At baseline, after completion of 6-8 week intervention, and 4 weeks later
Other outcomes:
Locations:
city: Chicago
country: United States
facility: Northwestern University Feinberg School of Medicine
state: Illinois
Study officials:
affiliation: Northwestern University
name: Judith T Moskowitz
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT06053632: Young Age Soccer Player's Lower Limb Muscle Imbalance and Functional Status
Official title: The Effect of Eccentric Exercises on Lower Limb Muscle Imbalances and Functional Status of Young Female Football Players
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Healthy
Keywords: Young age soccer player
Eccentric hamstring exercise
Dynamic balance
Contractile muscle properties
Lead sponsor: Lithuanian Sports University
Sponsor class: OTHER
First posted: 2023-09-26
Enrollment: 20
Sex: FEMALE
Minimum age (years): 13
Maximum age (years): 15
Standard ages: CHILD
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: PREVENTION

Brief summary: A randomized controlled trial is designed to examine the effects of low-load and high-velocity eccentric exercises on lower limb muscular properties, imbalances and functional status of 13-15 years old female football players.

Detailed description: Twenty participants were included in the study. All participants were divided in two groups - control and experimental. In the experimental group (n=10) participants after team soccer training additional received 4 weeks eccentric exercises, in the control group (n=10) - did not perform additional exercises. The research group performed additional low-load and high-velocity - lying prone - eccentric hamstring exercise 3 times per week for 4 weeks. Pre- and post- training assessment included concentric/eccentric knee extension and flexion at 60°/s and 120°/s, changes in muscle contractile characteristics and dynamic balance.

Eligibility criteria: Inclusion Criteria:

* Healthy players able to participate in training and competitions.
* Playing football for at least 2 years.
* Regularly participating in team training, 2-3 times a week.

Exclusion Criteria:

* Female soccer players with a lower extremity injury (in a period of 6 months)
* Pain is less than 2 points on the Visual Analog Pain Scale.
* Irregular exercise
* The number of years of training attended is too low

Primary outcomes:
measure: Changes in isokinetic peak torque (with Biodex)
timeFrame: Baseline and after 4 weeks
measure: Dynamic balance
timeFrame: Baseline and after 4 weeks
measure: Changes in muscle contractile characteristics (with tensiomyography (TMG))
timeFrame: Baseline and after 4 weeks
Secondary outcomes:
Other outcomes:
Locations:
city: Kaunas
country: Lithuania
facility: Lithuanian Sports University
Study officials:
affiliation: Lithuanian Sports University
name: Dovile Kiele, PhD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT02637232: Mirvaso® Utilisation and Patient Satisfaction Evaluation (MUSE)
Official title: Mirvaso® Utilisation and Patient Satisfaction Evaluation
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Rosacea
Lead sponsor: Galderma R&D
Sponsor class: INDUSTRY
Collaborators: name: Chiltern International Inc.
First posted: 2015-12-22
Enrollment: 301
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: OTHER
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: patient with persistent facial erythema of rosacea

Brief summary: The aim of the study is to evaluate the level of satisfaction among patients to whom Mirvaso® / Onreltea TM (trade mark) is prescribed.


Eligibility criteria: Inclusion Criteria:

* Patients to whom the physician has already decided to prescribe Mirvaso® /OnrelteaTM according to package insert

Primary outcomes:
measure: Satisfaction Among Patients to Whom Mirvaso®/OnrelteaTM is Prescribed Question
timeFrame: Week 4
Secondary outcomes:
Other outcomes:
Locations:
city: Hamilton
country: Canada
facility: Investigator site 1
Study officials:
References: