louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT02917252: How Orally Consumed 3-hydroxybuturate Alters Metabolism
Official title: Ketone Bodies Ingested Orally Alter Metabolism for Glucose, Lipid, and Protein
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Acute Ketosis
Lead sponsor: University of Aarhus
Sponsor class: OTHER
First posted: 2016-09-28
Enrollment: 6
Sex: MALE
Minimum age (years): 18
Maximum age (years): 40
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: CROSSOVER
Primary purpose: BASIC_SCIENCE

Brief summary: This study evaluate the metabolic effects of orally ingested ketone bodies. The study is conducted as a randomized, cross over study.

Detailed description: Subject participate for two separate days; i) intervention, ii) placebo. Intervention: subjects drink ketone body solution. Tracer kinetics on glucose and lipid metabolism is applied. Muscle tissue and adipose tissue biopsies are taken.

Placebo: subjects drink saline. Same sampling as on intervention day.

Eligibility criteria: Inclusion Criteria:

* BMI 20-30

Exclusion Criteria:

* Smoking
* alcohol or drug abuse
* Critically ill

Primary outcomes:
measure: 3-hydroxybuturate
timeFrame: 0-270 minutes
Secondary outcomes:
measure: Glucose
timeFrame: 0-270 minutes
measure: lipid metabolism
timeFrame: 0-270 minutes
Other outcomes:
Locations:
city: Aarhus
country: Denmark
facility: Aarhus University Hospital
Study officials:
References:
citation: Svart M, Rittig N, Pedersen SB, Jessen N, Moller N. Oral 3-hydroxybutyrate ingestion decreases endogenous glucose production, lipolysis, and hormone-sensitive lipase phosphorylation in adipose tissue in men: a human randomized, controlled, crossover trial. Diabet Med. 2021 Feb;38(2):e14385. doi: 10.1111/dme.14385. Epub 2020 Sep 22.
Clinical trial NCT00543452: Effect of Oxygen on Core Temperature
Official title: Effect of Oxygen on Core Temperature
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Cardiac Disease
Cheyne-Stokes Respiration
Lead sponsor: Umeå University
Sponsor class: OTHER
Collaborators: name: Swedish Heart Lung Foundation
First posted: 2007-10-15
Enrollment: 40
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: BASIC_SCIENCE

Brief summary: Study of the effect of oxygen on the frequency of central apnea, sleep and body temperature in patients with a cardiac disease


Eligibility criteria: Inclusion Criteria:

* Cardiac disease and Cheyne-Stokes respiration and controls without Cheyne-Stokes respiration

Exclusion Criteria:

* Obstructive sleep apnea

Primary outcomes:
measure: Core temperature
timeFrame: One day
Secondary outcomes:
measure: Sleep stages, apnea-hypopnea index
timeFrame: One day
Other outcomes:
Locations:
city: Umeå
country: Sweden
facility: Dept of respiratory medicine
Study officials:
affiliation: Dept Respiratory Medicine, University Hospital, Umeå
name: Karl A Franklin, MD, PhD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT06701552: Prevalence of MIH in Young Adults At Cairo University Dental Hospital and Its Link to Dental Cavities: a Cross-Sectional Study
Official title: MIH Prevalence Among Early Adulthood Patients Attending Cairo University Dental Educational Hospital and Its Correlation to Dental Caries Experience: a Cross-Sectional Study
Study type: OBSERVATIONAL
Overall status: NOT_YET_RECRUITING
Conditions: Molar Incisor Hypomineralization
Dental Caries
Keywords: MIH
Lead sponsor: Cairo University
Sponsor class: OTHER
First posted: 2024-11-22
Enrollment: 266
Sex: ALL
Minimum age (years): 18
Maximum age (years): 30
Standard ages: ADULT
Accepts healthy volunteers: yes
Observational model: OTHER
Time perspective: CROSS_SECTIONAL
Sampling method: PROBABILITY_SAMPLE
Study population: Egyptian participants whose between 18 and 30 years old, both sexes will be included

Brief summary: We are conducting a study to understand how often MIH (Molar Incisor Hypomineralization) occurs and whether it is linked to a higher chance of dental cavities (caries).

MIH is a condition where the enamel (the hard outer surface) of the first permanent molars and incisors (front teeth) doesn't develop properly, making these teeth more prone to damage and decay. We are looking at whether patients with MIH have more cavities in their teeth compared to patients without MIH.

This study aims to help us learn more about the connection between MIH and dental health, so we can improve care and prevention strategies for kids at risk of cavities.


Eligibility criteria: Inclusion Criteria:

* patients whose age between 18 and 30 years old provide informed consent Egyptian patients from both sexes

Exclusion Criteria:

* patients under or over this age group patients undergoing orthodontic treatment patients who refuse to participate

Primary outcomes:
measure: prevalence of MIH
timeFrame: one year
Secondary outcomes:
Other outcomes:
Locations:
city: Cairo
country: Egypt
facility: Faculty of Dentistry, Cairo University
Study officials:
References:
Clinical trial NCT06979752: Efficacy and Safety of Tran Cannula in Combined Pseudoexfoliative Glaucoma and Cataract Surgery Compared With Augmented Ocular Irrigation
Official title: Efficacy and Safety of Tran Cannula in Combined Pseudoexfoliative Glaucoma and Cataract Surgery Compared With Augmented Ocular Irrigation
Study type: INTERVENTIONAL
Overall status: RECRUITING
Phase: NA
Conditions: Glaucoma, Open Angle, Pseudo-exfoliative
Cataract
Lead sponsor: Hôpital Privé de la Baie
Sponsor class: OTHER
First posted: 2025-05-20
Enrollment: 58
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: Pseudoexfoliative glaucoma is a glaucoma secondary to pseudoexfoliative syndrome; cataract surgery is often more difficult, with more complications. Tran's cannula is a single-use irrigation system designed for cleaning, with the pseudoexfoliative material remaining in the trabecular meshwork.

The main objective of this study is to evaluate the efficacy of the Tran cannula, in comparison with increased irrigation, in lowering intraocular pressure (IOP) in patients with pseudoexfoliative glaucoma and treated for glaucoma, and with an indication for isolated cataract surgery.


Eligibility criteria: Inclusion Criteria:

* Patients with cataract and early-to-moderate pseudoexfoliative glaucoma (GPX) scheduled for isolated cataract surgery.
* Reliable visual field, Humphrey 24-2, Sita-Fast, with typical glaucoma alterations, and with mean deviation ≤-12 dB.
* OCT with ganglion cell alterations and fibers typical of glaucoma.
* Typical glaucomatous neuropathy
* Slit-lamp signs of pseudoexfoliation.
* Open angle (2 to 4, according to Shaffer classification) determined by gonioscopy.
* Untreated eye pressure \>21 mmHg and \<33 mmHg

Exclusion Criteria:

* Presence of other ophthalmological pathologies (except cataract or mild dry eye)
* History of intraocular surgery in the last 12 months, history of trauma
* History of laser trabeculoplasty (TLA or SLT) in the previous 12 months
* Visual acuity below "finger count
* Myopia ≥ 6 dioptres, hyperopia ≥ 5 dioptres
* Iridocorneal angle closure (and angle-closure glaucoma), any other type of non-pseudoexfoliative glaucoma, iris neovascularization
* Pachymetry \< 490 μm or \> 620 μm; or corneal pathology or other condition that makes accurate IOP measurements with flattening tonometry, ultrasonic pachymetry or specular microscopy impossible.
* Presence of severe systemic pathologies

Primary outcomes:
measure: Intraocular pressure measure
timeFrame: day 1, day 30, month 3, month 6 and month 12 after surgery
Secondary outcomes:
Other outcomes:
Locations:
city: Avranches
country: France
facility: Hôpital Privé de la Baie
city: Paris
country: France
facility: Fondation Rothschild
Study officials:
References:
Clinical trial NCT00240552: Fosamprenavir Expanded Access
Official title: An Open-label Phase III Study to Provide Access to Fosamprenavir and to Assess the Long Term Safety and Tolerability of Fosamprenavir Containing Regimens in HIV Infected Patients With Limited Treatment Options
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE4
Conditions: Infection, Human Immunodeficiency Virus
Keywords: protease inhibitor
Treatment Experienced
amprenavir
fosamprenavir
GW433908
HIV
pro drug
Lead sponsor: ViiV Healthcare
Sponsor class: INDUSTRY
Collaborators: name: GlaxoSmithKline
First posted: 2005-10-18
Enrollment: 85
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no

Brief summary: This open-label study will enable HIV-infected adults with limited treatment options to receive fosamprenavir until commercial supplies are available in Switzerland.


Eligibility criteria: Inclusion Criteria:

* HIV-1 infected subjects.
* Subjects must belong to one of the following populations:

  1. Subjects with limited treatment options due to viral resistance, interactions, or tolerability issues with other antiretroviral drugs.
  2. Subjects who already receive amprenavir (Agenerase®)
  3. Subjects for whom once daily dosing of antiretroviral therapy is indicated, including, once daily dosing with fosamprenavir/ritonavir.

Primary outcomes:
Secondary outcomes:
Other outcomes:
Locations:
city: Aarau
country: Switzerland
facility: GSK Investigational Site
city: Basel
country: Switzerland
facility: GSK Investigational Site
city: Bern
country: Switzerland
facility: GSK Investigational Site
city: Bruderholz
country: Switzerland
facility: GSK Investigational Site
city: La Chaux-de-Fonds
country: Switzerland
facility: GSK Investigational Site
city: Lausanne
country: Switzerland
facility: GSK Investigational Site
city: Lugano
country: Switzerland
facility: GSK Investigational Site
city: Luzern
country: Switzerland
facility: GSK Investigational Site
city: St Gallen
country: Switzerland
facility: GSK Investigational Site
city: Zurich
country: Switzerland
facility: GSK Investigational Site
city: Zurich
country: Switzerland
facility: GSK Investigational Site
city: Zurich
country: Switzerland
facility: GSK Investigational Site
Study officials:
affiliation: ViiV Healthcare
name: GSK Clinical Trials
role: STUDY_DIRECTOR
References:
Clinical trial NCT05106452: Effect of ANI on Intraoperative Opioid Consumption
Official title: Intraoperative Analgesia Management in Gynecological Surgery With Erector Spinae Block
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Analgesia
Nociceptive Pain
Nerve Block
Pain
Keywords: Analgesia nociception index
Pain monitoring
Analgesia
Lead sponsor: Zonguldak Bulent Ecevit University
Sponsor class: OTHER
Collaborators: name: Zeynep Koc
First posted: 2021-11-03
Enrollment: 35
Sex: FEMALE
Minimum age (years): 18
Maximum age (years): 65
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: female patients gynecological surgery under general anesthesia

Brief summary: The aim of the study is to compare the analgesic nociception index (ANI), which is used to determine the dose of analgesic agent needed in the intraoperative period, with the conventional method in patients with erector spinae block who underwent gynecological surgery under general anesthesia.


Eligibility criteria: Inclusion Criteria:

* ASA I-II-III risk group
* Patients who underwent gynecological surgery under general anesthesia, who underwent erector spina block, and whose pain was followed by analgesia nociception index or conventional methods for intraoperative pain monitoring
* Patients whose informed consent was read and consent was obtained from them and their guardians

Exclusion Criteria:

* cardiac rhythm disorder
* central-autonomic nervous system disease
* neuropsychiatric disease
* receiving opioid therapy
* Use of drugs that will affect cardiac autonomic regulation
* Known allergy to the drugs to be applied
* Contraindicated for ESP block
* Patients who do not agree to participate in the study will not be included in the study.
* Patients who were administered drugs to stabilize the patient's hemodynamics during the operation

Primary outcomes:
measure: intraoperative opioid consumption
timeFrame: during the surgery
Secondary outcomes:
measure: emergence time
timeFrame: at the end of the surgery
measure: VAS pain scores
timeFrame: during her stay in the recovery unit
measure: duration of stay in recovery room
timeFrame: at the end of the surgery
measure: nausea and vomiting i
timeFrame: during her stay in the recovery unit
Other outcomes:
Locations:
city: Zonguldak
country: Turkey
facility: Zonguldak Bülent Ecevit University Medicine Faculty
state: Kozlu
Study officials:
References:
Clinical trial NCT04096352: Virtual Reality in Teachers' Vocal Motor Behavior Acquisition (VirtuVox)
Official title: Virtual Reality in Teachers' Vocal Motor Behavior Acquisition (VirtuVox): Randomized Controlled Trial
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Voice Disorders
Virtual Reality Therapy
Keywords: Speech Therapy
Virtual Reality
Teacher's voice
Background Noise
School Teachers
Lead sponsor: University of Liege
Sponsor class: OTHER
Collaborators: name: Universite du Quebec en Outaouais
First posted: 2019-09-19
Enrollment: 41
Sex: ALL
Minimum age (years): 18
Maximum age (years): 40
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: PREVENTION

Brief summary: Scientific literature supports that teachers are at greater risk for voice disorders than the general population. In the classroom, the teacher's voice represents the main communication tool. Optimal voice use is indispensable to ensure effective teaching and preserve the teacher's vocal health.

This project investigates how virtual reality (VR) facilitates the learning of effective vocal skills and their application in real-world contexts. Based on acoustic analyses and self-assessment scales, the investigators compare 100 future teachers randomly assigned in two groups. The experimental group (n=50) receives a voice training by VR simulations and voice information. The control group (n=50) only receives voice information.

Detailed description: Experimental group participants receive direct method (three 1-hour sessions of voice training by virtual reality simulations over a course of 3 weeks) and indirect method (one 1-hour session of information on voice function and voice hygiene). Control group participants receive indirect method (one 1-hour session of information on voice function and voice hygiene).

Eligibility criteria: Inclusion Criteria:

* future teacher having completed at least one internship as a schoolteacher
* speaking French fluently

Exclusion Criteria:

* hearing impairment
* voice pathology at the time of the study

Primary outcomes:
measure: Self-perceived voice changes between the baseline and the end of the intervention
timeFrame: 3 weeks
measure: Voice frequency changes between the baseline and the end of the intervention
timeFrame: 3 weeks
measure: Voice intensity changes between the baseline and the end of the intervention
timeFrame: 3 weeks
measure: Voice spectrum changes between the baseline and the end of the intervention
timeFrame: 3 weeks
measure: Speech rate changes between the baseline and the end of the intervention
timeFrame: 3 weeks
Secondary outcomes:
Other outcomes:
Locations:
city: Liège
country: Belgium
facility: Université de Liège
state: Wallonia
Study officials:
affiliation: University of Liege
name: Angélique Remacle, Ph.D.
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT01537952: Microbiologic Findings of Acute Facial Palsy in Children
Official title: Microbiologic Findings of Acute Facial Palsy in Children
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Facial Paralysis
Keywords: facial paralysis, facial nerve, borreliosis, Bell's palsy
Lead sponsor: University of Helsinki
Sponsor class: OTHER
Collaborators: name: Helsinki University Central Hospital
First posted: 2012-02-23
Enrollment: 46
Sex: ALL
Maximum age (years): 16
Standard ages: CHILD
Accepts healthy volunteers: no
Observational model: CASE_ONLY
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Tertiary university Hospital, children 0-16 years old

Brief summary: Objective: Microbiologic etiologies of facial palsy in children were investigated.

Study design: Prospective clinical study. Methods: Forty-six children aged 0-16 years with facial palsy comprised the study group. Paired serum samples and cerebrospinal fluid were tested to find indications (antibodies, growth of the microbe, or nucleic acids) of microbes putatively associated with facial palsy. The microbes tested were herpes simplex virus-1 and -2, varicella-zoster virus, human herpesvirus-6, Mycoplasma pneumoniae, Borrelia burgdorferi, influenza A and B-, picorna-, cytomegalo-, parainfluenza-, respiratory syncytial-, coxsackie B5-, adeno-, and enteroviruses, Chlamydia psittaci, and Toxoplasma gondii. Besides the routine tests in clinical practice, serum and cerebrospinal fluid samples were tested with a highly sensitive microarray assay for DNA of herpes simplex virus-1 and -2, human herpesvirus-6A , -6B, -7, Epstein-Barr-, cytomegalo-, and varicella-zoster viruses.


Eligibility criteria: Inclusion Criteria:

* Age 0-16
* Facial palsy

Primary outcomes:
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
References:
citation: Kanerva M, Nissinen J, Moilanen K, Maki M, Lahdenne P, Pitkaranta A. Microbiologic findings in acute facial palsy in children. Otol Neurotol. 2013 Sep;34(7):e82-7. doi: 10.1097/MAO.0b013e318289844c.
Clinical trial NCT03012152: A Comparative Study Between Oncoplastic Breast Surgery and Standard Conservative Surgery:Margin Status and Patient Satisfaction
Official title: A Comparative Study Between Oncoplastic Breast Surgery and Standard Conservative Surgery:Margin Status and Patient Satisfaction Among Egyptian Females
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Breastcancer
Keywords: Oncoplastic surgery
Standard conservative surgery
Patient satisfaction
Margin Status
Lead sponsor: Ain Shams University
Sponsor class: OTHER
First posted: 2017-01-06
Enrollment: 70
Sex: FEMALE
Maximum age (years): 60
Standard ages: CHILD
ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: This non randomized study is a comparative study between standard conservative breast surgery and oncoplastic surgery as regard margin status and patient satisfaction.

Detailed description: This planned study was conducted on 70 female patients presented to our tertiary referral breast unit at Ain Shams University hospitals with breast cancer amid the period from September 2012 to May 2013 .

Every one of them signed an informed consent to partake in this study that was approved in a meeting held by the ethical committee on august 2012 at Ain Shams University. All patients sharing in the study received closed envelope before surgery in a randomized way in which the surgical technique is written either standard conservative surgery or oncoplastic surgery(Double Blind).

Our patients were partitioned into 2 equal groups: group A (35patients) who underwent standard conservative surgery, group B (35patients) who underwent oncoplastic surgery.

Eligibility criteria: Inclusion Criteria:

* Female Patients with stage 1,2 breast cancer.

Exclusion Criteria:

* Patients \>60 years.
* Patients with previous breast surgery.
* patients candidate for mastectomy or palliative excision. Patients with collagen disease.

Primary outcomes:
measure: Margins in all specimens measured in millimeters 2.
timeFrame: 2 years
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
References:
Clinical trial NCT04912752: Copy Number Variation in CHRNA7 Gene in Migraine and Gene Expression
Official title: Copy Number Variation in Migraine and Gene Expression
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Migraine
Lead sponsor: University of Gaziantep
Sponsor class: OTHER
First posted: 2021-06-03
Enrollment: 200
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: BASIC_SCIENCE

Brief summary: Migraine is a common and possible hereditary disease. Copy number variation (CNV) is a phenomenon in which parts of the genome are repeated and the number of repeats in the genome varies between individuals in the human population.The CHRNA7 gene has a major role in the neuropsychiatric phenotypes observed in patients. The 15q13.3 gain/loss variation in this gene may be associated with migraine.

Detailed description: Migraine is a common neurological disorder. Although they have different genetic bases according to their types, cholinergic receptors after calcium channels play an important role in the clinic and genetics of the disease. Neuronal acetylcholine receptor subunit alpha-7, also known as nAChRα7, is a protein that in humans is encoded by the CHRNA7 gene.

Eligibility criteria: Inclusion Criteria:

Migraine

Exclusion Criteria:

Vascular problems

Primary outcomes:
measure: CNV number
timeFrame: 1 year
Secondary outcomes:
Other outcomes:
Locations:
city: Gaziantep
country: Turkey
facility: Medicine
state: Şehitkamil
Study officials:
affiliation: Assist
name: Mehmet Fatih Özaltun, MD
role: PRINCIPAL_INVESTIGATOR
References: