Clinical trial NCT03894111: ICU Mortality Predictors of Trauma Patients
Official title: Prognostic Effect of Neutrophil \ Lymphocyte Ratio, Lactate Level and Apache 2 Score on Mortality in Intensive Care Trauma Patients at First Hospitalizations
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: İntensive Care Unit
Keywords: trauma, mortality
Lead sponsor: Balikesir University
Sponsor class: OTHER
First posted: 2019-03-28
Enrollment: 107
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: OTHER
Time perspective: RETROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: all trauvma patients in one year

Brief summary: In this study, the data of the patients who were hospitalized due to trauma in intensive care unit (ICU) were examined in their first development. The mortality rate and the factors affecting mortality in these patients were determined

Detailed description: In this study, 107 trauma patients were examined. Patients were divided into two groups according to ICU results: survivors (Group 1) and deceased patients (Group2). Patients were rated in terms of age, Neutrophil lymphocyte ratio (NLR) , mean platelet volüme (MPV), lactat value, intensive care unit stay, APACHE 2 soring systems. Mortality rate and the factors affecting this rate were examined.

83 of the patients were male (77.58%) and 24 were female (22.42%). The mean age was 46 years. The mean value of lactate level was 3.25. MPV mean value was 10.34. NLR mean value was 8.23 and Apache 2 score mean value was 22.8. The average length of stay in hospital was 11.33 days. When the intergroup mortality was evaluated in terms of the relationship between continuous variables, there was a statistically significant difference in apache 2 score. No statistically significant difference was found between age, lactate, MPV, NRL and length of hospital stay.

NRL, MPV, Lactate levels were not suitable for evaluation of trauma patients as a early prognostic factor in the first day ICU admission. The investigators think that the use of trauma scoring systems such as apache 2 related to mortality during first hospitalization in ICU is more appropriate.

Eligibility criteria: Inclusion Criteria:

* trauvma patients

Exclusion Criteria:

* systemic inflammatory diseases
* cancer
* renal failure
* cardiac failure
* serebro vascular diseases

Primary outcomes:
measure: mortallty
timeFrame: 28 days
Secondary outcomes:
Other outcomes:
Locations:
city: Balikesir
country: Turkey
facility: Balikesir City Hospital
Study officials:
affiliation: Netherlands: Ministry of Health, Welfare and Sports
name: bülent atik, md
role: PRINCIPAL_INVESTIGATOR
References:
citation: Zahorec R. Ratio of neutrophil to lymphocyte counts--rapid and simple parameter of systemic inflammation and stress in critically ill. Bratisl Lek Listy. 2001;102(1):5-14. English, Slovak.
citation: Chen W, Yang J, Li B, Peng G, Li T, Li L, Wang S. Neutrophil to Lymphocyte Ratio as a Novel Predictor of Outcome in Patients With Severe Traumatic Brain Injury. J Head Trauma Rehabil. 2018 Jan/Feb;33(1):E53-E59. doi: 10.1097/HTR.0000000000000320.
citation: Dilektasli E, Inaba K, Haltmeier T, Wong MD, Clark D, Benjamin ER, Lam L, Demetriades D. The prognostic value of neutrophil-to-lymphocyte ratio on mortality in critically ill trauma patients. J Trauma Acute Care Surg. 2016 Nov;81(5):882-888. doi: 10.1097/TA.0000000000000980.