Clinical trial NCT03014856: Metabolic Phenotypes in Childhood Obesity
Official title: Identification of Metabolic Phenotypes in Childhood Obesity by 1H-NMR Metabolomics of Blood Plasma
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Obesity, Pediatric
Keywords: Metabolic syndrome
Metabolomics
NMR spectroscopy
Lead sponsor: Hasselt University
Sponsor class: OTHER
Collaborators: name: Jessa Hospital
First posted: 2017-01-09
Enrollment: 102
Sex: ALL
Minimum age (years): 8
Maximum age (years): 18
Standard ages: CHILD
ADULT
Accepts healthy volunteers: yes
Observational model: CASE_CONTROL
Time perspective: CROSS_SECTIONAL
Sampling method: PROBABILITY_SAMPLE
Study population: 65 overweight and obese (OB) children and 37 normal-weight (NW) controls aged 8 to 18 years

Brief summary: This study provides a sound basis towards a better understanding of the biochemical mechanisms behind childhood obesity and its metabolic phenotypes, which will be of great importance towards the development of more personalized prevention and treatment in future.

Detailed description: The aim of this study was to identify the plasma metabolic profile associated with childhood obesity and its phenotypes..

This cross-sectional study was set-up to examine the metabolic profile in fasting plasma samples from 65 overweight and obese (OB) children and 37 normal-weight (NW) controls aged 8 to 18 years. The obtained plasma 1H-NMR spectra were rationally divided into 110 integration regions, representing the metabolic phenotype. These integration regions reflect the relative metabolite concentrations and were used as statistical variables to construct a classification model in discriminating between OB and NW children and adolescents. In addition, two metabolic phenotypes were defined within the OB group, i.e. the metabolically "healthy" obese (MHO) and metabolically unhealthy obese (MUO) phenotype which are both classified as obese but with respectively, none (MHO) or at least two components (MUO) of the metabolic syndrome.

Eligibility criteria: Inclusion Criteria:

* aged 8 to 18
* normal-weight, overweight or obese according to the International Obesity Task Force (IOTF) Body Mass Index (BMI) criteria
* fasted for at least 8 hours

Exclusion Criteria:

* Subjects taking any medication or having serious chronic or acute illness within two weeks preceding the clinical examination,

Primary outcomes:
measure: metabolic phenotype of childhood obesity
timeFrame: day 1
Secondary outcomes:
measure: metabolic phenotype of metabolically healthy and unhealthy obese children and adolescents
timeFrame: day 1
Other outcomes:
Locations:
Study officials:
affiliation: Institute of Material Research, Hasselt University
name: Peter Adriaensens, PhD
role: PRINCIPAL_INVESTIGATOR
affiliation: Hasselt University
name: Liene Bervoets, PhD
role: STUDY_CHAIR
affiliation: Jessa Ziekenhuis Hasselt
name: Guy Massa, PhD, MD
role: STUDY_CHAIR
affiliation: Institute of Material Research, Hasselt University
name: Wanda Guedens, PhD
role: STUDY_CHAIR
affiliation: Institute of Material Research, Hasselt University
name: Gunter Reekmans, Ing
role: STUDY_CHAIR
affiliation: BIOMED, Hasselt University
name: Jean-Paul Noben, PhD
role: STUDY_CHAIR
References:
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citation: Bervoets L, Massa G, Guedens W, Reekmans G, Noben JP, Adriaensens P. Identification of metabolic phenotypes in childhood obesity by 1H NMR metabolomics of blood plasma. Future Sci OA. 2018 May 23;4(6):FSO310. doi: 10.4155/fsoa-2017-0146. eCollection 2018 Jul.