Clinical trial NCT01208311: Acoustic Liver Biopsy in Normals and in Patients With Cirrhosis Using Endoscopic Ultrasound
Official title: Acoustic Liver Biopsy in Normals and in Patients With Cirrhosis Using Endoscopic Ultrasound.
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Alcoholism
Cirrhosis
Hepatitis c
Keywords: Alcoholic cirrhosis
hepatitis c cirrhosis
cirrhosis
Lead sponsor: Northwell Health
Sponsor class: OTHER
First posted: 2010-09-23
Enrollment: 7
Sex: ALL
Minimum age (years): 20
Maximum age (years): 70
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Collect endoscopic ultrasound images form normal subjects, alcoholic liver patients and patients with hepatitis C Cirrhosis.

Brief summary: The purpose of this study is to determine the amount of fibrosis in the liver of hepatitis C patients with advanced fibrosis, using endoscopic ultrasound.

Detailed description: Background: Transabdominal ultrasound cannot be used to quantitate fibrosis in patients with cirrhosis due to variability in the abdominal wall thickness and composition. This variability can be eliminated by using endoscopic ultrasound.

Aim: To determine the amount of fibrosis in the liver of hepatitis C patients with advanced fibrosis, using endoscopic ultrasound.

Eligibility criteria: Inclusion Criteria:

* hepatic cirrhosis and hepatitis C and undergoing endoscopy
* Alcoholic liver and undergoing endoscopy
* Normal liver undergoing endoscopy

Exclusion Criteria:

* pregnancy
* Children

Primary outcomes:
measure: Luminosity on ultrasound
timeFrame: Once at the time of the endoscopic ultrasound
Secondary outcomes:
Other outcomes:
Locations:
city: New Hyde Park
country: United States
facility: LIJ Medical Center- NSLIJ Health System
state: New York
Study officials:
affiliation: Northwell Health
name: Larry S Miller, M.D
role: PRINCIPAL_INVESTIGATOR
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citation: Andanappa HK, Dai Q, Korimilli A, Panganamamula K, Friedenberg F, Miller L. Acoustic liver biopsy using endoscopic ultrasound. Dig Dis Sci. 2008 Apr;53(4):1078-83. doi: 10.1007/s10620-008-0211-4. Epub 2008 Feb 13.