Clinical trial NCT05904171: Cognitive, Affective, and Motor Effects of Tangotherapy in Parkinson's Disease
Official title: Cognitive, Affective, and Motor Effects of Tangotherapy in Parkinson's Disease
Study type: INTERVENTIONAL
Overall status: RECRUITING
Phase: NA
Conditions: Parkinson Disease
Keywords: Parkinson's Disease
Argentine Tango
Dance Therapy
Cognition
Lead sponsor: Istituto Auxologico Italiano
Sponsor class: OTHER
First posted: 2023-06-15
Enrollment: 42
Sex: ALL
Minimum age (years): 40
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: Neuroscientific research has shown a close relationship between physical fitness and cognition, showing a positive effect of physical activity (e.g., aerobic activity) on the maintenance of psycho-cognitive well-being in the elderly. In particular, dancing seems to be very effective, as it involves both motor and multisensory aspects (touch, sight, hearing, proprioception), stimulating memory, motor learning and social interaction. In fact, dance increases sensory-motor skills and cognitive performance in the neurologically healthy elderly. Dance-based therapeutic approaches, in particular Argentine tango, have also been implemented in the context of neurodegenerative pathologies, including Parkinson's disease (PD) where motor (i.e., tremors, postural instability, motor slowdown) and cognitive difficulties (e.g., executive deficits) may coexist. Most of these studies have so far demonstrated a significant improvement in balance and a reduction in motor symptoms, while evidence regarding cognitive and emotional benefits brought about by dance remains limited. When investigated, cognitive benefits have often been evaluated at the level of global cognition (i.e., screening tests), without a detailed characterization of the effects of tango on cognitive and affective functioning (e.g., executive functions, social cognition, depressive symptoms), central aspects in Parkinson's disease.


Eligibility criteria: Inclusion Criteria:

* Clinical diagnosis of mild-moderate Parkinson's Disease (modified Hoehn\&Yahr Scale 1-3)

Exclusion Criteria:

* Having attended Argentine Tango classes in the past year;
* Having attended Physical Therapy rehabilitation in the past month;
* Other neurological diseases (e.g., stroke, traumatic brain injury, brain tumors)
* Dementia
* Any clinical condition not compatible with physical activity
* Deep Brain Stimulation of infusion pumps implants

Primary outcomes:
measure: Change in Parkinson's Disease Cognitive Rating Scale (PD-CRS) - total score
timeFrame: At the beginning of the treatment, at the end of the treatment (i.e., after 6 weeks), and at 45 days follow-up
measure: Change in Hospital Anxiety and Depression Scale (HADS) - total score
timeFrame: At the beginning of the treatment, at the end of the treatment (i.e., after 6 weeks), and at 45 days follow-up
measure: Change in Health-related quality of Life (EQ-5D-5L) - total score
timeFrame: At the beginning of the treatment, at the end of the treatment (i.e., after 6 weeks), and at 45 days follow-up
measure: Change in Stroop Task - reading time
timeFrame: At the beginning of the treatment, at the end of the treatment (i.e., after 6 weeks), and at 45 days follow-up
measure: Change in 6 minutes walking Test (6MWT) - Distance Walked
timeFrame: At the beginning of the treatment, at the end of the treatment (i.e., after 6 weeks), and at 45 days follow-up
measure: Change in Timed Up and Go (TUG) test - Execution Time
timeFrame: At the beginning of the treatment, at the end of the treatment (i.e., after 6 weeks), and at 45 days follow-up
measure: Change in 10 meters walking test (10mWT) - Execution Time
timeFrame: At the beginning of the treatment, at the end of the treatment (i.e., after 6 weeks), and at 45 days follow-up
Secondary outcomes:
Other outcomes:
Locations:
city: Milan
country: Italy
facility: Istituto Auxologico Italiano IRCCS
state: Lombardia
Study officials:
affiliation: Laboratorio di Neuropsicologia, IRCCS Istituto Auxologico Italiano
name: Nadia Bolognini, PhD
role: PRINCIPAL_INVESTIGATOR
References:
citation: Carvalho A, Rea IM, Parimon T, Cusack BJ. Physical activity and cognitive function in individuals over 60 years of age: a systematic review. Clin Interv Aging. 2014 Apr 12;9:661-82. doi: 10.2147/CIA.S55520. eCollection 2014.
citation: Kattenstroth JC, Kalisch T, Holt S, Tegenthoff M, Dinse HR. Six months of dance intervention enhances postural, sensorimotor, and cognitive performance in elderly without affecting cardio-respiratory functions. Front Aging Neurosci. 2013 Feb 26;5:5. doi: 10.3389/fnagi.2013.00005. eCollection 2013.
citation: Kattenstroth JC, Kolankowska I, Kalisch T, Dinse HR. Superior sensory, motor, and cognitive performance in elderly individuals with multi-year dancing activities. Front Aging Neurosci. 2010 Jul 21;2:31. doi: 10.3389/fnagi.2010.00031. eCollection 2010.
citation: Ismail SR, Lee SWH, Merom D, Megat Kamaruddin PSN, Chong MS, Ong T, Lai NM. Evidence of disease severity, cognitive and physical outcomes of dance interventions for persons with Parkinson's Disease: a systematic review and meta-analysis. BMC Geriatr. 2021 Sep 22;21(1):503. doi: 10.1186/s12877-021-02446-w.
citation: Duncan RP, Earhart GM. Randomized controlled trial of community-based dancing to modify disease progression in Parkinson disease. Neurorehabil Neural Repair. 2012 Feb;26(2):132-43. doi: 10.1177/1545968311421614. Epub 2011 Sep 29.
citation: Rios Romenets S, Anang J, Fereshtehnejad SM, Pelletier A, Postuma R. Tango for treatment of motor and non-motor manifestations in Parkinson's disease: a randomized control study. Complement Ther Med. 2015 Apr;23(2):175-84. doi: 10.1016/j.ctim.2015.01.015. Epub 2015 Feb 9.