louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT04656509: Effects of Short Duration High-intensity Interval Training on Peak Oxygen Consumption
Official title: Effects of Short Duration High-intensity Interval Training on Peak Oxygen Consumption
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Cardiovascular Fitness
Keywords: exercise
cardiovascular fitness
sprinting
performance
Lead sponsor: University of Texas at Austin
Sponsor class: OTHER
First posted: 2020-12-07
Enrollment: 11
Sex: ALL
Minimum age (years): 18
Maximum age (years): 49
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: TREATMENT

Brief summary: High-intensity interval training (HIIT) is an effective tool to improve cardiovascular fitness and maximal anaerobic power. Different methods of HIIT have been studied but the effect of a maximal effort cycling and very short exercise time (i.e., 4-s) with short recovery time (15-30 s) and a high number of repetitions (i.e., 30 bouts) is unknown.

Detailed description: The investigators examined the effects of training at maximal anaerobic power during cycling (PC) on maximal anaerobic power, peak oxygen consumption (VO2peak), and total blood volume in 11 young healthy individuals (age: 21.3±0.5 y) (6 men, 5 women). Methods: Participants trained three times a week for eight weeks performing a PC program consisting of 30 bouts of 4-s at an all-out intensity (i.e., 2 minutes of exercise per session). The cardiovascular stress progressively increased over the weeks by decreasing the recovery time between sprints (30 to 24 to 15-s) and thus session time decreased from 17 to \< 10 min.

Eligibility criteria: Inclusion Criteria:

Young (18-30), Healthy, Recreationally active, but untrained (not meeting ACSM's recommendations of 150 min/week of moderate-vigorous aerobic exercise) -

Exclusion Criteria:

Cardiovascular disease Smoking Subjects who were exercising regularly (\>75 min/week) were excluded.

-

Primary outcomes:
measure: Cardiovascular changes
timeFrame: Pre and post training (8 weeks)
measure: Blood volume changes
timeFrame: Pre and post training (8 weeks)
Secondary outcomes:
measure: Performance changes
timeFrame: Pre and post training (8 weeks)
Other outcomes:
Locations:
city: Austin
country: United States
facility: Human Performance Laboratory, Department of Kinesiology and Health Education, the University of Texas at Austin
state: Texas
Study officials:
affiliation: University of Texas at Austin
name: Edward F Coyle, Ph.D.
role: STUDY_DIRECTOR
References:
citation: Satiroglu R, Lalande S, Hong S, Nagel MJ, Coyle EF. Four-Second Power Cycling Training Increases Maximal Anaerobic Power, Peak Oxygen Consumption, and Total Blood Volume. Med Sci Sports Exerc. 2021 Dec 1;53(12):2536-2542. doi: 10.1249/MSS.0000000000002748.
Clinical trial NCT00864409: Local Infiltration Analgesia With Ropivacaine Versus Placebo in Bilateral Hip Arthroplasty
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: PHASE4
Conditions: Postoperative Pain
Hip Arthroplasty
Keywords: postoperative pain
total hip arthroplasty
Lead sponsor: Hvidovre University Hospital
Sponsor class: OTHER
First posted: 2009-03-18
Enrollment: 12
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Primary purpose: TREATMENT

Brief summary: High-volume infiltration analgesia may be effective in postoperative pain management following total hip arthroplasty. In this randomized, double-blind trial patients undergoing bilateral hip arthoplasty are randomized to receive high-volume local anesthetic infiltration in one hip and similar infiltration with saline (placebo) in the other hip.


Eligibility criteria: Inclusion Criteria:

* scheduled for bilateral total hip arthroplasty
* able to speak and understand Danish

Exclusion Criteria:

* treatment with opioids or steroids

Primary outcomes:
measure: postoperative pain
timeFrame: 0-48 hours postoperative
Secondary outcomes:
Other outcomes:
Locations:
city: Hvidovre
country: Denmark
facility: Hviovre University Hospital
Study officials:
References:
Clinical trial NCT03802409: The Real Word Study of Albumin-binding Taxol for Lung Cancer Treatment
Official title: The Real Word Study of Albumin-binding Taxol for Lung Cancer Treatment
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Lung Cancer
Keywords: Albumin-binding taxol
Lead sponsor: The First Affiliated Hospital of Anhui Medical University
Sponsor class: OTHER
First posted: 2019-01-14
Enrollment: 500
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Confirmed by Histopathology or Cytology of Lung cancer

Brief summary: The investigators conduct the real world study to explore the efficacy and safety of Albumin-binding taxol in lung cancer .


Eligibility criteria: Inclusion Criteria:

1. Male or female patients .
2. Confirmed by Histopathology or Cytology of Lung Cancer
3. Patients should be voluntary to the trial and provide with signed informed consent
4. The researchers believe patients can benefit from the study.

Exclusion Criteria:

1. Patients with a known history of allergic reactions and/or hypersensitivity attributed to Albumin-binding taxol or its accessories
2. Pregnant or lactating women
3. Patients with Albumin-binding taxol contraindications
4. Patients of doctors considered unsuitable for the trial

Primary outcomes:
measure: Progress free survival
timeFrame: 1 year
Secondary outcomes:
measure: Overall Survival
timeFrame: 3 year
measure: disease control rate
timeFrame: 1 year
measure: Objective tumor response rate
timeFrame: 1 year
Other outcomes:
measure: Quality of life score
timeFrame: 1 year
measure: adverse events
timeFrame: 1 year
Locations:
city: Hefei
country: China
facility: First Affiliated Hospital of Anhui Medical University
state: Anhui
Study officials:
References:
Clinical trial NCT06043609: Outcome Evaluation After Fertility Preservation
Official title: Outcome Evaluation After Fertility Preservation
Study type: OBSERVATIONAL
Overall status: RECRUITING
Conditions: Cancer
Fertility Issues
Lead sponsor: Chinese University of Hong Kong
Sponsor class: OTHER
First posted: 2023-09-21
Enrollment: 100
Sex: ALL
Maximum age (years): 60
Standard ages: CHILD
ADULT
Accepts healthy volunteers: no
Observational model: CASE_ONLY
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: All patients who have undergone or will seek for fertility preservation services in PWH will be invited to participate.

Brief summary: It is important to evaluate outcomes after different fertility preservation strategies. Therefore, this study aims to assess the outcomes after different fertility preservation strategies and identify any factors that may affect their reproductive outcome.

Detailed description: All patients who have undergone or will seek fertility preservation services in PWH will be invited to participate. For those patients who have undergone fertility preservation services in PWH, when they come back to use their frozen gametes or embryos, they will also be invited to participate.

Medical record assessment When patients come for fertility preservation consultation in PWH, they will be invited to participate. The medical notes of these patients undergoing fertility preservation services will be reviewed. The baseline characteristics including the socio-demographic background, past medical history, details of the surgical procedures, and the subsequent reproductive outcome, will be obtained by reviewing their hospital record. The participants will not be required to take any extra procedures.

Eligibility criteria: Inclusion Criteria:

* Patients aged from 0-50 years old
* Patients with any illness or who will undergo any type of treatment that may cause irreversible damage to their fertility, such as extensive abdominal surgery, high toxicity medication and treatments;
* Patients seek for fertility preservation services

Exclusion Criteria:

-Patients unable to provide consent/assent (i.e. significant psychiatric problems/cognitive delay)

Primary outcomes:
measure: To determine any factors that may affect the success rate of different fertility preservation methods.
timeFrame: 10 years
Secondary outcomes:
measure: To assess the pregnancy rate after different fertility preservation methods.
timeFrame: 10 years
measure: To report on the frequency of surgical complications
timeFrame: 10 years
Other outcomes:
Locations:
city: Hong Kong
country: Hong Kong
facility: Prince of Wales Hospital
Study officials:
affiliation: Chinese University of Hong Kong
name: Jacqueline CHUNG, MBBS
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT04887909: Prediction of Postoperative Visual Acuity in Cataract Patients Using a Macular Optical Coherence Tomography-based Deep Learning Method
Official title: Prediction of Postoperative Visual Acuity in Cataract Patients Using a Macular Optical Coherence Tomography-based Deep Learning Method
Study type: OBSERVATIONAL
Overall status: NOT_YET_RECRUITING
Conditions: Data Collecting
Keywords: artificial intelligence
deep learning
cataract surgery
acuity vision
macular
optical coherence tomography
Lead sponsor: Second Affiliated Hospital, School of Medicine, Zhejiang University
Sponsor class: OTHER
First posted: 2021-05-14
Enrollment: 1100
Sex: ALL
Minimum age (years): 50
Maximum age (years): 90
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: OTHER
Time perspective: RETROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: Cataract surgery was performed in ophthalmic hospital affiliated to Medical College of Zhejiang University

Brief summary: The purpose of this study is to collect the macular OCT images and preoperative and postoperative visual acuity of cataract patients who had been operated in the eye center of the Second Affiliated Hospital of Zhejiang University Medical College, and to train a model that can relatively accurately predict the postoperative visual acuity of patients by deep learing.


Eligibility criteria: Inclusion Criteria:

* Senile cataract patients, with or without macular disease, the impact of cataract on vision has affected the daily life of patients.

Exclusion Criteria:

* Glasses can obviously improve eyesight
* In addition to macular disease, combined with other eye diseases that seriously affect vision, resulting in no significant improvement in postoperative vision
* Complicated cataract surgery due to trauma and other reasons
* Combined with other eye diseases not suitable for intraocular lens implantation
* Patients with systemic diseases who cannot tolerate surgery

Primary outcomes:
measure: Uncorrected distance visual acuity
timeFrame: 1 month postoperatively
measure: Best Corrected Visual Acuity
timeFrame: 1 month postoperatively
measure: Macular optical coherence tomography
timeFrame: 1 month postoperatively
Secondary outcomes:
Other outcomes:
Locations:
city: Hangzhou
country: China
facility: Second Affiliated Hospital, Zhejiang University School of Medicine
Study officials:
References:
Clinical trial NCT04126109: Parental Attitudes in Invitro Fertilization
Official title: Parental Reports Toward in Vitro Fertilization
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Infertility, Female
Lead sponsor: Aljazeera Hospital
Sponsor class: OTHER
Collaborators: name: Cairo University
First posted: 2019-10-15
Enrollment: 400
Sex: ALL
Minimum age (years): 20
Maximum age (years): 44
Standard ages: ADULT
Accepts healthy volunteers: no
Observational model: OTHER
Time perspective: RETROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Women who are enrolled in ICI and became pregnant

Brief summary: The relationship between revelation of mode of conception and child behavior is not known

Detailed description: start of assisted reproductive techniques over the past 25 years made many otherwise infertile couples to become parents to genetically related children.

Eligibility criteria: Inclusion Criteria:

* Parents who were enrolled in ICSI and pregnancy occurred

Exclusion Criteria:

* ICSI with no pregnancy

Primary outcomes:
measure: The number of women who got pregnant that will tell others by that
timeFrame: within one year
Secondary outcomes:
Other outcomes:
Locations:
city: Giza
country: Egypt
facility: Algazeerah
Study officials:
affiliation: Algezeera hospitaland National Research Centre ,Egypt
name: Mahmoud Alalfy, PhD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT00482209: Study of 400mcg Versus 800mcg Buccal Misoprostol Following Mifepristone 200mg for Abortion up to 63 Days Gestation
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Induced Abortion
Keywords: mifepristone, misoprostol, medical abortion
Lead sponsor: Gynuity Health Projects
Sponsor class: OTHER
First posted: 2007-06-05
Enrollment: 1220
Sex: FEMALE
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: This double-blind, randomized study will compare the efficacy and acceptability of mifepristone 200mg followed in 36-48 hours by 400mcg or 800mcg of buccal misoprostol (i.e., in the cheeks) for termination of pregnancy in women up to 63 days LMP.

Detailed description: The goal of this study is to provide answers to the following four questions:

1. Is a regimen of medical abortion with mifepristone using 400mcg buccal misoprostol as effective and acceptable as using 800mcg buccal misoprostol up to 63 days since the last menstrual period (LMP)?
2. Are the side effects with buccal use tolerable for women?
3. Is buccal administration of misoprostol acceptable to women?
4. When given a choice, do women prefer to take misoprostol at home or in the clinic?

Eligibility criteria: Inclusion Criteria:

* Women 18 years or over presenting for abortion services who consent to participate
* good general health
* assessed by a clinician to have an intrauterine pregnancy less than 64 days LMP on Study Day 1 and to be eligible for medical abortion
* Have ready access to a telephone and emergency transportation;
* Be willing to provide an address and/or telephone number for purposes of follow-up

Exclusion Criteria:

* Conditions which contraindicate the use of mifepristone or misoprostol
* Women presenting for medical abortion who do not consent to participate

Primary outcomes:
measure: Need for surgical completion for ongoing viable pregnancies at follow up visit (Study day 12-15) or for incomplete abortion at extended follow up visit (Study day (19-22).
timeFrame: Study day 12-15 for ongoing viable pregnancies or Study day 19-22 for incomplete abortion at extended follow up visit
Secondary outcomes:
measure: Side-effects, acceptability for women
timeFrame: side effects and acceptability recorded at exit interview
Other outcomes:
Locations:
city: Tbilisi
country: Georgia
facility: Maternity House #2
city: Tbilisi
country: Georgia
facility: Maternity House #4
city: Tbilisi
country: Georgia
facility: Zhordania Institute of Human Reproduction
city: Ho Chi Minh City
country: Vietnam
facility: Hocmon Hospital
Study officials:
affiliation: Gynuity Health Projects
name: Beverly Winikoff, MD, MPH
role: PRINCIPAL_INVESTIGATOR
affiliation: Gynuity Health Projects
name: Erica Chong, MPH
role: STUDY_DIRECTOR
affiliation: Gynuity Health Projects
name: Tamuna Tsereteli, MD, MSc, PhD
role: STUDY_DIRECTOR
References:
Clinical trial NCT00982007: Efficacy and Safety of Intravenous Ferric Carboxymaltose (FCM) in Patients With Iron Deficiency Anemia (IDA)
Official title: A Multi-center, Randomized, Active Controlled Study to Investigate the Efficacy and Safety of Intravenous Ferric Carboxymaltose (FCM) in Patients With Iron Deficiency Anemia (IDA)
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE3
Conditions: Iron Deficiency Anemia
Keywords: IDA
Lead sponsor: American Regent, Inc.
Sponsor class: INDUSTRY
First posted: 2009-09-22
Enrollment: 997
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The main objective of this study is to demonstrate the efficacy and safety of an investigational intravenous (IV) iron, ferric carboxymaltose (FCM), compared to oral iron in subjects who have iron deficiency anemia (IDA) and have shown an unsatisfactory response to oral iron.


Eligibility criteria: Inclusion Criteria:

* Male or female subjects ≥ to 18 years of age and able to give informed consent.
* Diagnosis of Iron Deficiency Anemia (IDA).
* Hemoglobin (Hgb) ≤ to 11 g/dL.
* Ferritin ≤ to 100 ng/mL or ≤ 300 when Transferrin Saturation (TSAT) was ≤ 30%.
* Must demonstrate an unsatisfactory response or intolerance to oral iron.

Exclusion Criteria:

* Known hypersensitivity reaction to any component of ferric carboxymaltose or ferrous sulfate.
* Previously randomized in a clinical study of Ferric Carboxymaltose (FCM).
* Requires dialysis for treatment of chronic kidney disease.
* No evidence of iron deficiency.
* Any non-viral infection.
* AST or ALT at screen 1, as determined by central labs, greater than 1.5 times the upper limit of normal.
* Known positive hepatitis with evidence of active disease.
* Received an investigational drug within 30 days of screening.
* Alcohol or drug abuse within the past 6 months.
* Hemochromatosis or other iron storage disorders.
* Estimated life expectancy of less than 6 months or, for cancer patients, an ECOG Performance Status greater than 1.
* Any other laboratory abnormality, medical condition, or psychiatric disorders which in the opinion of the investigator would put the subject's disease management at risk or may result in the subject being unable to comply with study requirements.
* Pregnant or sexually-active females who are of childbearing potential and who are not willing to use an acceptable form of contraception.

Primary outcomes:
measure: Mean Increase From Baseline to the Highest Observed Hemoglobin Value Between Baseline and Day 35 or Time of Intervention for Patients Taking FCM as Compared to That for Patients Taking Ferrous Sulfate.
timeFrame: Day 35
Secondary outcomes:
Other outcomes:
Locations:
city: Norristown
country: United States
facility: Luitpold Pharmaceuticals, Inc.
state: Pennsylvania
Study officials:
References:
Clinical trial NCT05920707: Common and Differentiated Representations Between Social Exclusion and Social Separation
Official title: Common and Differentiated Representations Between Social Exclusion and Social Separation
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Healthy
Keywords: Social exclusion
Social separation
Oxytocin
Arginine Vasopressin
fMRI
Lead sponsor: University of Electronic Science and Technology of China
Sponsor class: OTHER
First posted: 2023-06-27
Enrollment: 120
Sex: ALL
Minimum age (years): 18
Maximum age (years): 30
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Intervention model description: Randomized placebo-controlled double-blind between-subject design
Primary purpose: BASIC_SCIENCE

Brief summary: Explore the shared or separated neural mechanisms of social exclusion and social segregation and compare differential effects of AVP and OXT on these social interaction function.

Detailed description: A large body of research has shown that there are differences in the neural representation between social exclusion and social segregation, but the results are inconsistent, and the exploration of the neural basis is still insufficient. In addition, there are two mainstream theoretical explanations for these differences, namely the construction-level theory and the emotion-based theory, but there is no consistent theoretical model yet. Therefore, further exploration is necessary to confirm the cognitive and neural mechanisms underlying the differences between social exclusion and social segregation, and to attempt to reveal the theoretical explanations for these differences. In this project, the investigators propose to perform behavioral and functional magnetic resonance imaging (fMRI) techniques to examine the shared or separate neural mechanisms of social exclusion and social segregation (exp 1: social exclusion; exp 2: social separation) and investigate the modulatory effects of OXT/AVP on them (PLC/24IU OXT/20IU AVP).

Eligibility criteria: Inclusion Criteria:

1. Healthy subjects;
2. Without any past or present psychiatric or neurological disorders;
3. Without any current psychotherapeutic medication.

EXclusion Criteria:

1. With any past or present psychiatric or neurological disorders;
2. With any current psychotherapeutic medication.

Primary outcomes:
measure: Neural index: OXT and AVP effects on fMRI based- social exclusion and social separation tasks
timeFrame: 45 minutes after treatment administration
measure: Behavioral index: behavioral ratings of social exclusion and social separation tasks
timeFrame: Immediately after fMRI scanning
Secondary outcomes:
Other outcomes:
Locations:
city: Chengdu
country: China
facility: University of Electronic Science and Technology of China(UESTC)
state: Sichuan
Study officials:
affiliation: University of Electronic Science and Technology of China
name: Siying Wang, Dr
role: STUDY_CHAIR
References:
Clinical trial NCT03247907: Humidification Needs
Official title: Humidification Needs
Study type: INTERVENTIONAL
Overall status: TERMINATED
Phase: NA
Conditions: Obstructive Sleep Apnea
Lead sponsor: Fisher and Paykel Healthcare
Sponsor class: INDUSTRY
First posted: 2017-08-14
Enrollment: 10
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: CROSSOVER
Primary purpose: OTHER

Brief summary: A study undertaken to investigate mouth leak for airway discomfort/dryness while using CPAP. This study will also measure how much humidification is required to treat subsequent upper airway discomfort/dryness from mouth leak by utilizing different levels and types of humidification.


Eligibility criteria: Inclusion Criteria:

* Aged 18 and over

Exclusion Criteria:

* Inability to give consent
* Currently pregnant or think they may be pregnant
* Current nasal symptoms or chronic nasal disease
* Contraindicated for PAP therapy

Primary outcomes:
measure: Nasal Resistance
timeFrame: 8 Days
measure: Evaluation of Nasal Dryness and Discomfort
timeFrame: 8 Days
Secondary outcomes:
measure: Preference of Testing Condition
timeFrame: 8 Days
Other outcomes:
Locations:
city: East Tamaki
country: New Zealand
facility: Fisher and Paykel Healthcare
state: Auckland
Study officials:
References: