Clinical trial NCT02550132: The Role of the Rate of Force Application in Responses to Spinal Manipulation Therapy
Official title: Neuromechanical Response to Spinal Manipulation Therapy: Effects of a Constant Rate of Force Application
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Spinal Manipulation
Keywords: electromyography
biomechanical phenomena
dose-response relationship
musculoskeletal manipulations
spinal manipulation
Lead sponsor: Université du Québec à Trois-Rivières
Sponsor class: OTHER
Collaborators: name: Fondation Chiropratique du Québec
First posted: 2015-09-15
Enrollment: 25
Sex: ALL
Minimum age (years): 18
Maximum age (years): 50
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: BASIC_SCIENCE

Brief summary: The objective of the present study is to determine if spinal manipulations with a constant rate of force application but with different peak force and time to peak force lead to similar responses in healthy adults.

Detailed description: Although there are indirect evidences that the rate of force application modulates neuromuscular responses to spinal manipulation therapy (SMT) through peak force or thrust duration modulations, such an assumption remains to be confirmed. Therefore, the objective of the present study was to determine if different SMT force-time profiles where a constant rate of force application would be maintained (through the modulation of the peak force and the time to peak force) lead to similar neuromechanical responses. Based on the available data relative to the effect of SMT biomechanical parameters modulation, it was hypothesized that neuromuscular responses would be similar across SMT force-time profiles, while vertebral displacements would increase as SMT peak force increases.

Eligibility criteria: Inclusion Criteria:

* Healthy adult

Exclusion Criteria:

* Thoracic or lumbar pain
* History of back trauma or surgery
* Severe osteoarthritis
* Inflammatory arthritis
* Vascular conditions
* Contraindication to the use of SMT

Primary outcomes:
measure: Left T6 Normalized Root Mean Square (RMS) Value
timeFrame: During the 150N spinal manipulation procedure, assessed up to 2 seconds following thrust onset
measure: Left T8 Normalized Root Mean Square (RMS) Value
timeFrame: During the 150N spinal manipulation procedure, assessed up to 2 seconds following thrust onset
measure: Right T6 Normalized Root Mean Square (RMS) Value
timeFrame: During the 150N spinal manipulation procedure, assessed up to 2 seconds following thrust onset
measure: Right T8 Normalized Root Mean Square (RMS) Value
timeFrame: During the 150N spinal manipulation procedure, assessed up to 2 seconds following thrust onset
measure: Left T6 Normalized Root Mean Square (RMS) Value
timeFrame: During the 200N spinal manipulation procedure, assessed up to 2 seconds following thrust onset
measure: Left T8 Normalized Root Mean Square (RMS) Value
timeFrame: During the 200N spinal manipulation procedure, assessed up to 2 seconds following thrust onset
measure: Right T6 Normalized Root Mean Square (RMS) Value
timeFrame: During the 200N spinal manipulation procedure, assessed up to 2 seconds following thrust onset
measure: Right T8 Normalized Root Mean Square (RMS) Value
timeFrame: During the 200N spinal manipulation procedure, assessed up to 2 seconds following thrust onset
measure: Left T6 Normalized Root Mean Square (RMS) Value
timeFrame: During the 250N spinal manipulation procedure, assessed up to 2 seconds following thrust onset
measure: Left T8 Normalized Root Mean Square (RMS) Value
timeFrame: During the 250N spinal manipulation procedure, assessed up to 2 seconds following thrust onset
measure: Right T6 Normalized Root Mean Square (RMS) Value
timeFrame: During the 250N spinal manipulation procedure, assessed up to 2 seconds following thrust onset
measure: Right T8 Normalized Root Mean Square (RMS) Value
timeFrame: During the 250N spinal manipulation procedure, assessed up to 2 seconds following thrust onset
measure: Left T6 Normalized Root Mean Square (RMS) Value
timeFrame: During the 300N spinal manipulation procedure, assessed up to 2 seconds following thrust onset
measure: Left T8 Normalized Root Mean Square (RMS) Value
timeFrame: During the 300N spinal manipulation procedure, assessed up to 2 seconds following thrust onset
measure: Right T6 Normalized Root Mean Square (RMS) Value
timeFrame: During the 300N spinal manipulation procedure, assessed up to 2 seconds following thrust onset
measure: Right T8 Normalized Root Mean Square (RMS) Value
timeFrame: During the 300N spinal manipulation procedure, assessed up to 2 seconds following thrust onset
measure: Vertebral Displacement of the Sixth Thoracic Vertebra
timeFrame: During the 150N spinal manipulation procedure, assessed up to 2 seconds following thrust onset
measure: Vertebral Displacement of the Seventh Thoracic Vertebra
timeFrame: During the 150N spinal manipulation procedure, assessed up to 2 seconds following thrust onset
measure: Vertebral Displacement of the Eighth Thoracic Vertebra
timeFrame: During the 150N spinal manipulation procedure, assessed up to 2 seconds following thrust onset
measure: Vertebral Displacement of the Sixth Thoracic Vertebra
timeFrame: During the 200N spinal manipulation procedure, assessed up to 2 seconds following thrust onset
measure: Vertebral Displacement of the Seventh Thoracic Vertebra
timeFrame: During the 200N spinal manipulation procedure, assessed up to 2 seconds following thrust onset
measure: Vertebral Displacement of the Eighth Thoracic Vertebra
timeFrame: During the 200N spinal manipulation procedure, assessed up to 2 seconds following thrust onset
measure: Vertebral Displacement of the Sixth Thoracic Vertebra
timeFrame: During the 250N spinal manipulation procedure, assessed up to 2 seconds following thrust onset
measure: Vertebral Displacement of the Seventh Thoracic Vertebra
timeFrame: During the 250N spinal manipulation procedure, assessed up to 2 seconds following thrust onset
measure: Vertebral Displacement of the Eighth Thoracic Vertebra
timeFrame: During the 250N spinal manipulation procedure, assessed up to 2 seconds following thrust onset
measure: Vertebral Displacement of the Sixth Thoracic Vertebra
timeFrame: During the 300N spinal manipulation procedure, assessed up to 2 seconds following thrust onset
measure: Vertebral Displacement of the Seventh Thoracic Vertebra
timeFrame: During the 300N spinal manipulation procedure, assessed up to 2 seconds following thrust onset
measure: Vertebral Displacement of the Eighth Thoracic Vertebra
timeFrame: During the 300N spinal manipulation procedure, assessed up to 2 seconds following thrust onset
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
affiliation: Université du Québec à Trois-Rivières
name: Martin Descarreaux, DC, PhD
role: PRINCIPAL_INVESTIGATOR
References:
citation: Nougarou F, Page I, Loranger M, Dugas C, Descarreaux M. Neuromechanical response to spinal manipulation therapy: effects of a constant rate of force application. BMC Complement Altern Med. 2016 Jun 2;16:161. doi: 10.1186/s12906-016-1153-6.