Clinical trial NCT05190744: Probenecid (PB) to Treat Hereditary Nephrogenic Diabetes Insipidus (NDI), ADPKD Treated With Tolvaptan, and Severely Polyuric Patients With Previous Lithium Administration
Official title: A Multi-center, Open-Label, Exploratory Study to Assess the Efficacy of PB in Decreasing the Urine Output and Increasing the Urine Osmolality in Patients With Hereditary Nephrogenic Diabetes Insipidus, Patients With Autosomal Dominant Polycystic Kidney Disease Treated With Tolvaptan, And Severely Polyuric Patients With Previous Lithium Administration (Serendipity-PB1)
Study type: INTERVENTIONAL
Overall status: RECRUITING
Phase: PHASE2
Conditions: Autosomal Dominant Polycystic Kidney Disease
Nephrogenic Diabetes Insipidus
Acquired Nephrogenic Diabetes Insipidus
Congenital Nephrogenic Diabetes Insipidus
Keywords: Tolvaptan
ADPKD
Polycystic Kidney Disease
Nephrogenic Diabetes Insipidus (NDI)
Nephrogenic diabetes insipidus
Inherited nephrogenic diabetes insipidus
Diabetes Insipidus
Lithium
Lithium-induced nephrogenic diabetes insipidus
Vasopressin receptor antagonist
Tolvaptan-induced aquaresis
Lead sponsor: Mayo Clinic
Sponsor class: OTHER
Collaborators: name: Otsuka America Pharmaceutical
First posted: 2022-01-13
Enrollment: 36
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NON_RANDOMIZED
Intervention model: PARALLEL
Primary purpose: SUPPORTIVE_CARE

Brief summary: The purpose of this research is to study the effectiveness and safety of the medication PB in slowing the frequent urination related to tolvaptan as long-term treatment of Autosomal Dominant Polycystic Kidney Disease (ADPKD), or frequent urination related to inherited nephrogenic diabetes insipidus as an inherited condition or as an acquired condition from prior treatment with lithium.


Eligibility criteria: Inclusion Criteria:

* Male or female, ≥ 18 years of age (inclusive) at time of screening
* Diagnosis of one of the following:

  1. ADPKD(as delineated in cohort 1)
  2. Congenital NDI (as delineated in cohort 1)
  3. Lithium-induced NDI (as delineated in cohort 1)
* Glomerular filtration rate (GFR) ≥ 25 ml/min/1.73 m2 at time of screening visit calculated as in cohort
* 24 hours urine volume in baseline 1 visit ≥ 5000 ml/ day
* If hypertensive, blood pressure controlled on antihypertensives (\<130/80 mm Hg) at least 30 days before day 1. Antihypertensives may be adjusted at time of baseline 2 per PI discretion.
* Female participants (see details in cohort 1 inclusion criteria)
* Have read, understood, and provided written informed consent after the nature of the study has been fully explained and must be willing to comply with protocol requirements and study-related procedures.
* Negative urinary pregnancy test (if applicable) at baseline 2
* Capable of providing urine samples as dictated by the protocol

Exclusion Criteria:

* Advanced diabetes (e.g., glycosylated hemoglobin \[HgbA1c\] \>7.5%, and/or glycosuria by dipstick, significant proteinuria \[\>300 mcg albumin/mg creatinine\]), other significant kidney disease, kidney cancer, transplanted kidney, single kidney, kidney surgery within the past 6 months (including cyst drainage or fenestration) or acute kidney injury within 6 months prior to screening.
* Clinically significant incontinence, overactive bladder, or urinary retention (e.g., benign prostatic hyperplasia).
* Other significant chronic medical disease (heart failure, diabetes mellitus, liver disease, transient or persistent elevated transaminases)
* History of acute gout attack in the past 30 days
* History of clinically significant drug or alcohol abuse in the 2 years prior to screening visit.
* Uncontrolled hyperuricemia or active gout
* History of hepatotoxicity related to tolvaptan; or clinically significant liver disease or impairment; or alanine aminotransferase (ALT), aspartate aminotransferase (AST), or total bilirubin values \>1.2 x Upper Limit of Normal (ULN) during screening.
* Medical history or findings that preclude safe participation in the trial or participants who are likely to be non-compliant with trial procedures in the opinion of the investigator or medical monitor.
* Requirement for ongoing diuretic use.
* Participants who are currently taking, or are expected to be taking, strong or moderate CYP3A4 or CYP2C8 inhibitors or inducers including regular use of grapefruit juice, Seville oranges, or St. John's wort. If applicable, there should be a 14-day washout of these treatments prior to Day 1.
* Prior use of a sodium-glucose cotransporter 2 inhibitor (SGLT2i) (e.g., canagliflozin, dapagliflozin, empagliflozin, etc.) within the 2 months prior to screening visit or expected need for initiation of treatment with a SGLT2i inhibitor during the study. Current use of SGLT2i will be reviewed by PI and allow enrollment if patient has been on stable dose for at least 2 months.
* Prior use of a hypoxia-inducible factor prolyl hydroxylase (HIF-PH) inhibitor within the 2 months prior to screening visit or expected need for initiation of treatment with a HIF-PH inhibitor during the study;
* Participants who have taken any investigational drug or used an investigational device within 30 days, or 5 half-lives, whichever is longer, prior to screening visit 1a or plan to participate in an interventional trial during the study.
* Allergy to probenecid
* History of persistent hyponatremia
* Positive test results for hepatitis B surface antigen (HBsAg).
* Positive test results for hepatitis C (HCV) antibody (Anti-HCV), with the exception of participants for whom the reflex HCV RNA titer test is negative.

Primary outcomes:
measure: Change in urine osmolality
timeFrame: Baseline, 30 days
Secondary outcomes:
measure: Change in urine output
timeFrame: From Baseline 2 to Post Treatment Follow Up at the end of 5 weeks
Other outcomes:
Locations:
city: Jacksonville
country: United States
facility: Mayo Clinic
state: Florida
Study officials:
affiliation: Mayo Clinic
name: Fouad Chebib, MD
role: PRINCIPAL_INVESTIGATOR
References: