Clinical trial NCT02881892: Iplasma IL6, Procalcitonin and VEGF and Dialysate Level in CAPD Patients
Official title: Interleukin-6, Procalcitonin and Vascular Endothelial Growth Factor in Plasma and Dialysate Correlate With Peritoneal Solute Transport and Dialysis Adequacy in CAPD Patients
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Chronic Kidney Disease
Keywords: CAPD
Peritoneal solute transport rate
Dialysis adequacy
Lead sponsor: Bangkok Metropolitan Administration Medical College and Vajira Hospital
Sponsor class: OTHER_GOV
First posted: 2016-08-29
Enrollment: 26
Sex: ALL
Minimum age (years): 18
Maximum age (years): 80
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: CASE_ONLY
Time perspective: CROSS_SECTIONAL
Sampling method: NON_PROBABILITY_SAMPLE
Study population: CAPD patients age more than 18 years

Brief summary: The aim of study was to evaluated the correlation between plasma levels, dialysate appearance rate of VEGF, inflammatory cytokines (IL- 6, procalcitonin) and PSTR, dialysis adequacy in CAPD patients.

Detailed description: This cross -sectional study measured IL-6, procalcitonin and VEGF level in plasma and overnight effluent. PSTR of small solutes was evaluated by standard peritoneal equilibration test (standard PET). Weekly Kt/V and creatinine clearance (CCr ) were evaluated in all patients.

Eligibility criteria: Inclusion Criteria:

* Stable CAPD patients without previous history of peritonitis

Exclusion Criteria:

* HIV
* Other infections, tuberculosis or on immunosuppressive drugs,
* Autoimmune disease,
* Cancer
* Diagnosis of permanent ultrafiltration failure .

Primary outcomes:
measure: plasma level of VEGF, IL-6 and procalcitonin with the PSTR and dialysis adequacy in CAPD patients
timeFrame: 2 years
Secondary outcomes:
measure: Cytokines in diabetic and non-diabetic group
timeFrame: 2 years
Other outcomes:
Locations:
city: Bangkok
country: Thailand
facility: Renal Unit, BMA Medical College and Vajira Hospital
Study officials:
affiliation: Department of Medicine,Vajira Hospital,Navamindradhiraj University
name: Thananda Trakarnvniach, M.D.
role: PRINCIPAL_INVESTIGATOR
References:
citation: Oh KH, Jung JY, Yoon MO, Song A, Lee H, Ro H, Hwang YH, Kim DK, Margetts P, Ahn C. Intra-peritoneal interleukin-6 system is a potent determinant of the baseline peritoneal solute transport in incident peritoneal dialysis patients. Nephrol Dial Transplant. 2010 May;25(5):1639-46. doi: 10.1093/ndt/gfp670. Epub 2010 Jan 8.
citation: Alscher DM, Mettang T. Procalcitonin in peritoneal dialysis--a useful marker of inflammation? Perit Dial Int. 2005 Sep-Oct;25(5):441-4. No abstract available.
citation: Herget-Rosenthal S, Klein T, Marggraf G, Hirsch T, Jakob HG, Philipp T, Kribben A. Modulation and source of procalcitonin in reduced renal function and renal replacement therapy. Scand J Immunol. 2005 Feb;61(2):180-6. doi: 10.1111/j.0300-9475.2005.01545.x.
citation: Guz G, Colak B, Hizel K, Reis KA, Erten Y, Bali M, Sindel S. Procalcitonin and conventional markers of inflammation in peritoneal dialysis patients and peritonitis. Perit Dial Int. 2006 Mar-Apr;26(2):240-8.
citation: Pecoits-Filho R, Araujo MR, Lindholm B, Stenvinkel P, Abensur H, Romao JE Jr, Marcondes M, De Oliveira AH, Noronha IL. Plasma and dialysate IL-6 and VEGF concentrations are associated with high peritoneal solute transport rate. Nephrol Dial Transplant. 2002 Aug;17(8):1480-6. doi: 10.1093/ndt/17.8.1480.