Clinical trial NCT02603315: Vascularity Impact on the Treatment Outcome in Malignant Pleural Mesothelioma(VITMPM)
Official title: To Assess the Correlation Between the Predictive Factor of Vascularity (CD74) in Malignant Pleural Mesothelioma and Treatment Results (Response Rate, and Overall Survival )
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Malignant Pleural Mesotheliomas
Lead sponsor: Ain Shams University
Sponsor class: OTHER
First posted: 2015-11-11
Enrollment: 50
Sex: ALL
Minimum age (years): 39
Maximum age (years): 84
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: RETROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: Egyptian patients with confirmed malignant pleural mesothelioma

Brief summary: The purpose of this study is to To assess the correlation between the predictive factor of vascularity (CD74) in malignant pleural mesothelioma and treatment results (response rate, and overall survival) .

Detailed description: This is a randomized controlled retrospective study through Examination of paraffin blocks of the patient selected to be included in the study for assessment of the selected vascularity marker of malignant pleural mesothelioma of both types . The CD74 (LN2) antibody is intended for qualified laboratories to qualitatively identify by light microscopy the presence of associated antigens in sections of formalin-fixed paraffin-embedded tissue sections using Immunohistochemistry test methods.

Eligibility criteria: Inclusion Criteria:

* Histopathological confirmation of malignant pleural mesothelioma .
* Full clinical data.
* Availability for follow up: Personal communication will be attempted in order to collect missing information.

  3-The files of all patients will be reviewed to analyze the following :
* Operative data if done .
* Pathological review and immunohistochemistry.
* Laboratory investigations: (routine investigations: complete blood picture,liver and renal function test)
* Radiological investigations:( CXR and CT-chest, Abdominal and pelvic U\\S and MRI ).
* Treatment protocols applied: Radiotherapy and Chemotherapy.
* Response and survival after treatment .

Exclusion Criteria:

* cases not receive chemotherapy ,on available of evaluation after treatment

Primary outcomes:
measure: to correlate the results of the vascularity marker of pleural mesothelioma CD74 of patients attended to Ain Shams University hospitals with the result response of treatment by chemotherapy ,overall survival and progreeion free survival
timeFrame: 3-4 months
Secondary outcomes:
measure: assessment of vascular enothelial growth factor (VEGF) in patient with malignant pleural mesothelioma who attended to Ain Shams University and made comparison with the result of CD 74
timeFrame: 3-4 months
Other outcomes:
Locations:
city: Cairo
country: Egypt
facility: Ain Shams University Hospital
Study officials:
affiliation: Ain Shams University
name: Amr S Saad, MD
role: STUDY_DIRECTOR
affiliation: Ain Shams University
name: Mahmoud Ellithy, MD
role: STUDY_CHAIR
affiliation: Ain Shams University
name: Doaa Atef, MD
role: STUDY_DIRECTOR
affiliation: Ain Shams University
name: Hoda Abougabal, MD
role: STUDY_DIRECTOR
References: