Clinical trial NCT06424288: A Study to Test Whether Vicadrostat in Combination With Empagliflozin Helps People With Heart Failure
Official title: EASi-HF Preserved - A Phase III Double-blind, Randomised, Parallel-group Superiority Trial to Evaluate Efficacy and Safety of the Combined Use of Oral Vicadrostat (BI 690517) and Empagliflozin Compared With Placebo and Empagliflozin in Participants With Symptomatic Heart Failure (HF: NYHA II-IV) and Left Ventricular Ejection Fraction (LVEF) ≥40%
Study type: INTERVENTIONAL
Overall status: RECRUITING
Phase: PHASE3
Conditions: Heart Failure
Lead sponsor: Boehringer Ingelheim
Sponsor class: INDUSTRY
First posted: 2024-05-22
Enrollment: 6000
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: This study is open to adults aged 18 or above legal age with heart failure. People can join the study if they have heart failure symptoms and a left ventricular ejection fraction (LVEF) of 40% or more. The purpose of this study is to find out whether vicadrostat (BI 690517) in combination with empagliflozin helps people with heart failure.

Participants are put into 2 groups by chance. Every participant has an equal chance of being in each group. The groups are:

* Vicadrostat and empagliflozin group: participants take vicadrostat and empagliflozin as tablets once a day.
* Placebo and empagliflozin group: participants take placebo and empagliflozin as tablets once a day.

Participants can stay in the study as long as they benefit from treatment and can tolerate it. During this time, they visit their doctors regularly. The doctors regularly check participants' health and take note of any unwanted effects. The study staff may also contact the participants by phone. Participants also regularly answer questions about their well-being.

The study does not have a fixed duration. It continues until there is enough data to see if the treatment is working.


Eligibility criteria: Inclusion criteria:

1. At least 18 years old and at least of the legal age of consent in countries where it is greater than 18 years
2. Signed and dated written informed consent in accordance with ICH-GCP and local legislation prior to admission to the trial
3. Male or female participants. Women of childbearing potential (WOCBP) must be ready and able to use highly effective methods of birth control per International Conference on Harmonisation (ICH) M3 (R2) that result in a low failure rate of less than 1% per year when used consistently and correctly. A list of contraception methods meeting these criteria and instructions on the duration of their use is provided in the participant information
4. Chronic Heart failure (HF) diagnosed at least 3 months before Visit 1, and in New York Heart Association (NYHA) class II-IV at Visit 1, with left ventricular ejection fraction (LVEF) ≥40% per local reading. A historical LVEF may be used if it was measured within 12 months prior to Visit 1, or the LVEF may be measured after study consent has been obtained and before randomisation at Visit 2
5. Presence of structural heart abnormality (confirmed by any imaging modality; i.e. echocardiography at Visit 1, as defined by left ventricular hypertrophy or left atrial enlargement). Historical imaging may be used if performed within 12 months prior to Visit 1, or imaging may be completed after study consent has been obtained and before Visit 2
6. Elevated N-terminal pro-brain natriuretic peptide (NT-proBNP) at Visit 1, analysed at the central laboratory at Visit 1:

   1. in participants with body mass index (BMI) \<27 kg/m²: ≥300 pg/mL for participants without atrial fibrillation (Afib) or atrial flutter (Aflutter) (at Visit 1 electrocardiogram (ECG)) and ≥900 pg/mL for participants with Afib or Aflutter (at Visit 1 ECG)
   2. in participants with BMI ≥27 kg/m² to \<35 kg/m²: ≥220 pg/mL for participants without Afib or Aflutter (at Visit 1 ECG) and ≥660 pg/mL for participants with Afib or Aflutter (at Visit 1 ECG)
   3. in participants with BMI ≥35 kg/m²: ≥125 pg/mL for participants without Afib or Aflutter (at Visit 1 ECG) and ≥375 pg/mL for participants with Afib or Aflutter (at Visit 1 ECG)
7. At least one of the following:

   * Currently treated with diuretic therapy e.g. loop diuretics or thiazides, and on a stable dose for at least 1 week prior to Visit 1
   * Documented hospitalisation for HF within 6 months prior to Visit 1
   * Elevated NT-proBNP at Visit 1, analysed at the central laboratory at Visit 1

     * in participants without Afib or Aflutter (at Visit 1 ECG): ≥900 pg/mL
     * for participants with Afib or Aflutter (at Visit 1 ECG): ≥1800 pg/mL
   * Urine albumin-to-creatinine ratio (UACR) ≥30 mg/g, analysed at the central laboratory at Visit 1
8. Treated according to best possible standard of care (SOC) (disregarding Sodium-dependent glucose co-transporter 2 inhibitors (SGLT2is) and Mineralocorticoid receptor antagonists (MRAs)) in accordance with applicable HF local/international guidelines and judgment of the investigator Further inclusion criteria apply.

Exclusion criteria:

1. Treatment with an mineralocorticoid receptor antagonist (MRA) (e.g. spironolactone, eplerenone, finerenone) within 14 days prior to Visit 1 or requiring such treatment before randomisation or planned during the trial based on the judgment of the investigator. Treatment with MRA should not be interrupted with the intention of enrolment into the study
2. Treatment with amiloride, or other potassium-sparing diuretic within 14 days prior to Visit 1 or requiring such treatment before randomisation or planned during the trial based on the judgment of the investigator
3. Receiving the following treatments:

   * a direct renin inhibitor (e.g. aliskiren) at Visit 2
   * more than one angiotensin-converting enzyme inhibitor (ACEI), angiotensin receptor blocker (ARB) or angiotensin receptor-neprilysin inhibitor (ARNI) used simultaneously at Visit 2
   * In case of acute decompensated HF:

     * i.v. inotrope, i.v. vasodilating drug (e.g. nitrate, nitroprusside), or i.v. natriuretic peptide (e.g. nesiritide, carperitide), or mechanical support (e.g. intra-aortic balloon pump, endotracheal intubation, mechanical ventilation, any ventricular assist device) within 24 hours prior to randomisation (Visit 2)
     * i.v. diuretic with a dose that has been increased/intensified within 6 hours prior to randomisation (a stable dose of an i.v. diuretic is not exclusionary)
   * Systemic mineralocorticoid replacement therapy (e.g. fludrocortisone) at Visit 2
   * Other aldosterone synthase inhibitors, e.g. baxdrostat at Visit 2 or planned during the trial
4. Myocardial infarction (MI), transient ischemic attack (TIA), stroke, coronary artery bypass graft (CABG) surgery, heart valve surgery/intervention or any other major surgery (major according to the investigator's assessment) within 90 days prior to Visit 2, or scheduled for major elective surgery (e.g. hip replacement, coronary artery bypass graft surgery/CABG)
5. Percutaneous coronary intervention (PCI) ( scheduled or unscheduled) or any angiography using iodinated contrast agents in the 7 days prior to Visit 2
6. Heart transplant recipient, awaiting heart transplant, or currently implanted left ventricular assist device (LVAD)
7. Known cardiomyopathy based on infiltrative diseases (e.g. amyloidosis), accumulation diseases (e.g. haemochromatosis, Fabry disease), muscular dystrophies, hypertrophic obstructive cardiomyopathy or genetic hypertrophic cardiomyopathy,known pericardial constriction, or cardiomyopathy with potentially reversible cause such as stress or peripartum cardiomyopathy or cardiomyopathy induced by chemotherapy within the 12 months prior to Visit 1 and until Visit 2
8. Acute inflammatory heart disease, such as acute myocarditis, within the 90 days preceding prior to Visit 1 and until Visit 2
9. Known severe valvular heart disease (obstructive or regurgitant), as per investigator's judgment, or valvular heart disease scheduled for surgical or invasive procedures at Visit 1, or anticipated invasive treatment during the study Further exclusion criteria apply.

Primary outcomes:
measure: Time to first event of Cardiovascular (CV) death, hospitalisation for heart failure (HHF) or urgent heart failure (HF) visit
timeFrame: up to 42 months
Secondary outcomes:
measure: Key secondary endpoint: Time to first event of CV death or HHF
timeFrame: up to 42 months
measure: Key secondary endpoint: Occurrence of HHFs (first and recurrent)
timeFrame: up to 42 months
measure: Key secondary endpoint: Absolute change from baseline in Kansas City Cardiomyopathy Questionnaire Total Symptom Score (KCCQ-TSS) at Week 32
timeFrame: at baseline, at week 32
measure: Key secondary endpoint: Time to CV death
timeFrame: up to 42 months
measure: Key secondary endpoint: Time to all-cause mortality
timeFrame: up to 42 months
measure: Time to first HHF
timeFrame: up to 42 months
measure: Time to first occurrence of death from kidney failure, chronic dialysis* or renal transplant or onset of sustained reduction of ≥50% eGFR from baseline** or onset of sustained eGFR (CKD-EPI)cr <10 mL/min/1.73 m2 (composite renal endpoint)
timeFrame: up to 42 months
measure: Absolute change from baseline in KCCQ Clinical Summary Score (KCCQ-CSS) at Week 32
timeFrame: at baseline, at week 32
measure: Absolute change from baseline in KCCQ-TSS at Week 52
timeFrame: at baseline, at week 52
measure: Absolute change from baseline in KCCQ-OSS at Week 32
timeFrame: at baseline, at week 32
measure: Absolute change from baseline in KCCQ-OSS at Week 52
timeFrame: at baseline, at week 52
measure: Absolute change from baseline in systolic blood pressure (SBP) [mmHg] at Week 32 in participants with baseline SBP ≥130 mmHg
timeFrame: at baseline, at week 32
measure: Absolute chance from baseline in diastolic blood pressure (DBP) [mmHg] at Week 32 in participants with baseline DBP ≥80 mmHg
timeFrame: at baseline, at week 32
Other outcomes:
Locations:
city: Anniston
country: United States
facility: Pinnacle Research Group, LLC
state: Alabama
city: Mobile
country: United States
facility: Diagnostic and Medical Clinic
state: Alabama
city: Mobile
country: United States
facility: Mobile Heart Specialists, PC
state: Alabama
city: Chula Vista
country: United States
facility: Velocity Clinical Research-Chula Vista-67286
state: California
city: Orange
country: United States
facility: University of California Irvine
state: California
city: San Dimas
country: United States
facility: North America Research Institute
state: California
city: Tustin
country: United States
facility: Orange County Research Center
state: California
city: Valencia
country: United States
facility: Amicis Research Center (ARC)
state: California
city: Bridgeport
country: United States
facility: Bridgeport Hospital
state: Connecticut
city: Boca Raton
country: United States
facility: Excel Medical Clinical Trials
state: Florida
city: Brandon
country: United States
facility: Bay Area Cardiology
state: Florida
city: Clearwater
country: United States
facility: Clearwater Cardiovascular and Interventional Consultants
state: Florida
city: Daytona Beach
country: United States
facility: Cardiology Associates Research Co.
state: Florida
city: Gainesville
country: United States
facility: Malcom Randall VA Medical Center
state: Florida
city: Hallandale Beach
country: United States
facility: Velocity Clinical Research-Hallandale Beach-67888
state: Florida
city: Jacksonville
country: United States
facility: University of Florida Health Jacksonville
state: Florida
city: Jacksonville
country: United States
facility: East Coast Institute for Research, LLC-Jacksonville-55146
state: Florida
city: Jacksonville
country: United States
facility: First Coast Cardiovascular Institute
state: Florida
city: Largo
country: United States
facility: Clearwater Cardiovascular Consultants-Largo-69917
state: Florida
city: Miami
country: United States
facility: University of Miami
state: Florida
city: Miramar Beach
country: United States
facility: Sacred Heart Medical Specialty Group
state: Florida
city: Naples
country: United States
facility: Advanced Research for Health Improvement, LLC
state: Florida
city: Naples
country: United States
facility: Southwest Florida Research, LLC
state: Florida
city: Ocala
country: United States
facility: Ocala Research Institute, Inc
state: Florida
city: Ocala
country: United States
facility: Central Florida Heart Center - Paddock Park Campus
state: Florida
city: Port Charlotte
country: United States
facility: Charlotte Cardiovascular Institute, PA
state: Florida
city: Saint Augustine
country: United States
facility: East Coast Institute for Research, LLC-Saint Augustine-63032
state: Florida
city: Tampa
country: United States
facility: University of South Florida
state: Florida
city: Wellington
country: United States
facility: Cardiology Partners Clinical Research Institute
state: Florida
city: Wesley Chapel
country: United States
facility: Cozy Research LLC
state: Florida
city: Winter Park
country: United States
facility: Clinical Site Partners, LLC
state: Florida
city: Atlanta
country: United States
facility: Atlanta Clinical Research Centers
state: Georgia
city: Columbus
country: United States
facility: Columbus Regional Research Institute
state: Georgia
city: Johns Creek
country: United States
facility: NSC Research Inc
state: Georgia
city: Coeur d'Alene
country: United States
facility: Kootenai Medical Center
state: Idaho
city: Arlington Heights
country: United States
facility: Northwest Heart Clinical Research, LLC
state: Illinois
city: Chicago
country: United States
facility: Illinois Masonic Hospital
state: Illinois
city: Hazel Crest
country: United States
facility: Chicago Medical Research
state: Illinois
city: Libertyville
country: United States
facility: Clinical Investigation Specialists, Inc.-Libertyville-69941
state: Illinois
city: Park Ridge
country: United States
facility: AMR Park Ridge
state: Illinois
city: Elkhart
country: United States
facility: Midwest Cardiovascular Research and Education Foundation
state: Indiana
city: Indianapolis
country: United States
facility: St. Francis Medical Group-Indiana Heart Physicians, Inc
state: Indiana
city: Merrillville
country: United States
facility: Indiana Medical Research Institute
state: Indiana
city: Munster
country: United States
facility: Cardiovascular Research of Northwest Indiana, LLC
state: Indiana
city: Richmond
country: United States
facility: Reid Hospital
state: Indiana
city: West Des Moines
country: United States
facility: The Iowa Clinic, PC
state: Iowa
city: Wichita
country: United States
facility: West Houston Area Clinical Trial Consultants, LLC
state: Kansas
city: Louisville
country: United States
facility: University of Louisville Physicians
state: Kentucky
city: Louisville
country: United States
facility: Norton Heart Specialists
state: Kentucky
city: Alexandria
country: United States
facility: Cambridge Medical Trials-Alexandria-50533
state: Louisiana
city: Bossier City
country: United States
facility: Grace Research, LLC-Bossier City-51040
state: Louisiana
city: Hammond
country: United States
facility: Heart Clinic of Hammond
state: Louisiana
city: Shreveport
country: United States
facility: Grace Research, LLC-Shreveport-64616
state: Louisiana
city: Slidell
country: United States
facility: Louisiana Heart Center - Slidell
state: Louisiana
city: Towson
country: United States
facility: Spectrum Clinical Research
state: Maryland
city: Dearborn
country: United States
facility: AMR Dearborn
state: Michigan
city: Lansing
country: United States
facility: Sparrow Clinical Research Institute
state: Michigan
city: Ypsilanti
country: United States
facility: Trinity Health Michigan D/B/A Michigan Heart
state: Michigan
city: Minneapolis
country: United States
facility: Minneapolis VA Health Care System
state: Minnesota
city: Jackson
country: United States
facility: Jackson Heart Clinic, P.A.
state: Mississippi
city: Kansas City
country: United States
facility: Kansas City VA Medical Center
state: Missouri
city: North Kansas City
country: United States
facility: North Kansas City Hospital
state: Missouri
city: Saint Louis
country: United States
facility: St. Louis Heart and Vascular, P.C.
state: Missouri
city: Lincoln
country: United States
facility: Velocity Clinical Research-Lincoln-69943
state: Nebraska
city: Bridgewater
country: United States
facility: Advanced Heart Care, LLC
state: New Jersey
city: Manalapan
country: United States
facility: Garden State Heart Care, PC
state: New Jersey
city: Somerset
country: United States
facility: Singal, Dinesh
state: New Jersey
city: Bronx
country: United States
facility: Cardiac Care and Vascular Medicine, PLLC
state: New York
city: New Hyde Park
country: United States
facility: Long Island Cardiovascular Consultants
state: New York
city: New York
country: United States
facility: Gotham Cardiovascular Research
state: New York
city: New York
country: United States
facility: Mount Sinai Hospital-New York-52529
state: New York
city: Southampton
country: United States
facility: Northwell Health Physician Partners Cardiology
state: New York
city: Greensboro
country: United States
facility: Medication Management, LLC
state: North Carolina
city: Raleigh
country: United States
facility: WakeMed
state: North Carolina
city: Cleveland
country: United States
facility: VA Northeast Ohio Healthcare System
state: Ohio
city: Marion
country: United States
facility: Parminder Singh MD Research LLC
state: Ohio
city: Toledo
country: United States
facility: Mercy Health St. Vincent Medical Center
state: Ohio
city: Butler
country: United States
facility: Butler Health System Cardiovascular Consultants
state: Pennsylvania
city: Greenville
country: United States
facility: Upstate Cardiology, PA
state: South Carolina
city: Rapid City
country: United States
facility: Monument Health
state: South Dakota
city: Jackson
country: United States
facility: Helios CR Inc
state: Tennessee
city: Jefferson City
country: United States
facility: East Coast Institute For Research LLC
state: Tennessee
city: Amarillo
country: United States
facility: Pharmatex Research
state: Texas
city: Amarillo
country: United States
facility: Amarillo Heart Clinical Research Institute, Incorporated
state: Texas
city: Dallas
country: United States
facility: Texas Health Research and Education Institute
state: Texas
city: Dallas
country: United States
facility: Texas Health Research and Education Institute
state: Texas
city: Dallas
country: United States
facility: Southwest Family Medicine Associates
state: Texas
city: Dallas
country: United States
facility: University of Texas Southwestern Medical Center
state: Texas
city: Fort Worth
country: United States
facility: Ventavia Research Group
state: Texas
city: Katy
country: United States
facility: Private Practice Leadership, LLC
state: Texas
city: Kingwood
country: United States
facility: Texas Cardiology Research Center PLLC
state: Texas
city: Longview
country: United States
facility: DCOL Center for Clinical Research
state: Texas
city: McKinney
country: United States
facility: North Texas Research Associates
state: Texas
city: McKinney
country: United States
facility: Texas Institute Of Cardiology
state: Texas
city: Salt Lake City
country: United States
facility: University of Utah Hospital
state: Utah
city: Burlington
country: United States
facility: University of Vermont
state: Vermont
city: Falls Church
country: United States
facility: Inova Health Care Services
state: Virginia
city: Norfolk
country: United States
facility: Sentara Norfolk General Hospital
state: Virginia
city: Winchester
country: United States
facility: Selma Medical Associates, Winchester
state: Virginia
city: Seattle
country: United States
facility: Virginia Mason Medical Center
state: Washington
city: Madison
country: United States
facility: Drug Research and Analysis Corporation
state: Wisconsin
city: Waukesha
country: United States
facility: ProHealth Care Research Institute and Cardiology Associates
state: Wisconsin
city: Wausau
country: United States
facility: Aspirus Research Institute
state: Wisconsin
city: Bahia Blanca
country: Argentina
facility: Inst de Inv Clinicas-Bahia Blanca
city: Buenos Aire
country: Argentina
facility: Swiss Medical Center Barrio Parque
city: Ciudad Autonoma Buenos Aires
country: Argentina
facility: Mautalen- Salud e Investigacion
city: Ciudad Autonoma Buenos Aires
country: Argentina
facility: Centro Medico Dra Laura Maffei
city: Ciudad Autonoma Buenos Aires
country: Argentina
facility: Fundacion Favaloro
city: Ciudad Autonoma Buenos Aires
country: Argentina
facility: Instituto Cardiovascular de Buenos Aires
city: Ciudad Autonoma Buenos Aires
country: Argentina
facility: Glenny Corp. S.A. Bioclinica Argentina
city: Ciudad Autonoma de Bs As
country: Argentina
facility: Centro Medico Viamonte
city: Ciudad Autonoma de Buenos Aire
country: Argentina
facility: CINME - Centro De Investigaciones Metabolicas
city: Ciudad Autónoma de Bs As
country: Argentina
facility: Hospital Italiano de Buenos Aires
city: Ciudadela
country: Argentina
facility: Instituto Medico Elsa Perez SRL (IMEP)
city: Cordoba
country: Argentina
facility: Clinica Privada Colombo- Fundacion Clinica Colombo
city: Cordoba
country: Argentina
facility: Instituto Médico DAMIC S.R.L.
city: Cordoba
country: Argentina
facility: Centro Medico Luquez
city: Coronel Suarez
country: Argentina
facility: Clinica Coronel Suárez
city: Córdoba
country: Argentina
facility: Sanatorio Allende S.A.
city: Córdoba
country: Argentina
facility: Well Medica
city: La Plata
country: Argentina
facility: Hospital Italiano de La Plata
city: Mar del Plata
country: Argentina
facility: Centro de Investigaciones Medicas Mar del Plata
city: Pilar
country: Argentina
facility: Hospital Universitario Austral
city: Quilmes
country: Argentina
facility: Instituto de Investigaciones Clínicas de Quilmes
city: Ramos Mejía
country: Argentina
facility: DIM Clinica Privada
city: Rosario
country: Argentina
facility: Instituto de Investigaciones Clinicas de Rosario
city: Rosario
country: Argentina
facility: Instituto CAICI
city: Salta
country: Argentina
facility: Centro Cardiovascular Salta
city: San Martin
country: Argentina
facility: Corporacion Medica de Gral. San Martin S.A.
city: San Miguel de Tucuman
country: Argentina
facility: Investigaciones Clinicas Tucuman
city: San Miguel de Tucuman
country: Argentina
facility: Clinica Mayo
city: San Nicolas
country: Argentina
facility: Instituto de Investigaciones Clinicas San Nicolas
city: Santa Fe
country: Argentina
facility: Centro de Investigaciones Clínicas del Litoral
city: Villa Luro
country: Argentina
facility: CEMEDIC - Centro de Especialidades Medicas
city: Garran
country: Australia
facility: Canberra Hospital
state: Australian Capital Territory
city: Concord
country: Australia
facility: Concord Repatriation General Hospital
state: New South Wales
city: Gosford
country: Australia
facility: Gosford Hospital
state: New South Wales
city: Kingswood
country: Australia
facility: Nepean Hospital
state: New South Wales
city: Kotara
country: Australia
facility: Pendlebury Research
state: New South Wales
city: Brisbane
country: Australia
facility: Royal Brisbane and Women's Hospital
state: Queensland
city: Chermside
country: Australia
facility: Prince Charles Hospital
state: Queensland
city: Tugun
country: Australia
facility: John Flynn Private Hospital
state: Queensland
city: Adelaide
country: Australia
facility: Royal Adelaide Hospital
state: South Australia
city: Woodville
country: Australia
facility: The Queen Elizabeth Hospital
state: South Australia
city: Frankston
country: Australia
facility: Nightingale Research Victoria
state: Victoria
city: Parkville
country: Australia
facility: Royal Melbourne Hospital
state: Victoria
city: Perth
country: Australia
facility: Mount Hospital
state: Western Australia
city: Genk
country: Belgium
facility: Ziekenhuis Oost-Limburg - Campus Sint-Jan
city: Gent
country: Belgium
facility: AZ Sint-Lucas - Campus Sint Lucas
city: Gilly
country: Belgium
facility: Gilly - HOSP GHdC - site St.Joseph
city: Hasselt
country: Belgium
facility: Jessa Ziekenhuis
city: Kortrijk
country: Belgium
facility: Kortrijk - HOSP AZ Groeninge Kennedylaan
city: Leuven
country: Belgium
facility: UZ Leuven
city: Belo Horizonte
country: Brazil
facility: Hospital Vera Cruz
city: Belo Horizonte
country: Brazil
facility: Cardresearch Cardiologia Assistencial e de Pesquisas Ltda
city: Brasilia
country: Brazil
facility: L2IP -Instituto de Pesquisas Clínicas Ltda.
city: Brasília
country: Brazil
facility: CECAP - Centro de Cardiologia Clínica
city: Campina Grande do Sul
country: Brazil
facility: Hospital Angelina Caron
city: Campinas
country: Brazil
facility: IPECC - Instituto de Pesquisa Clínica de Campinas
city: Campinas
country: Brazil
facility: Centro Especializado em Cardiol Loema Instituto de Pesq Clin
city: Campo Largo
country: Brazil
facility: Hospital do Rocio
city: Curitiba
country: Brazil
facility: PUC Trials - Núcleo de Pesquisa Clínica da Escola de Medicina da PUC-PR
city: Goiânia
country: Brazil
facility: Via Medica
city: Marília
country: Brazil
facility: ICM - Instituto do Coracao de Marilia
city: Passo Fundo
country: Brazil
facility: Instituto Mederi de Pesquisa e Saude
city: Porto Alegre
country: Brazil
facility: Santa Casa de Misericórdia de Porto Alegre
city: Porto Alegre
country: Brazil
facility: Hospital de Clínicas de Porto Alegre
city: Porto Alegre
country: Brazil
facility: Universidade Federal do Rio Grande do Sul
city: Porto Alegre
country: Brazil
facility: Hospital Mae de Deus
city: Ribeirão Preto
country: Brazil
facility: Hospital das Clínicas FMRP-USP
city: Rio de Janeiro
country: Brazil
facility: Instituto Brasil de Pesquisa Clinica (IBPClin)
city: Rio de Janeiro
country: Brazil
facility: Hospital São Lucas Copacabana
city: Santo Andre
country: Brazil
facility: Pesquisare
city: Santo Andre
country: Brazil
facility: Praxis Pesquisa Medica
city: Sao Jose Rio Preto
country: Brazil
facility: Fundacao Faculdade Regional de Medicina, Sao Jose
city: Sao Paulo
country: Brazil
facility: Centro de Pesquisa Clinica - CPCLIN
city: Sao Paulo
country: Brazil
facility: CEPIC - Centro Paulista de Investigacao Clinica
city: São Paulo
country: Brazil
facility: INCOR e Hospital das Clínicas da Universidade de São Paulo
city: Vitória
country: Brazil
facility: CEDOES - Diagnóstico e Pesquisa,Vitória
city: Votuporanga
country: Brazil
facility: Integral Pesquisa e Ensino
city: Pleven
country: Bulgaria
facility: Ambulatory for Individual Practice for Specialized Medical Care in Cardiology - Dr Nikolay Iliev
city: Pleven
country: Bulgaria
facility: Medical Center Medconsult Pleven LTD
city: Pleven
country: Bulgaria
facility: Multiprofile Hospital for Active Treatment Heart and Brain EAD
city: Plovdiv
country: Bulgaria
facility: UMHAT Sv.Georgi
city: Sofia
country: Bulgaria
facility: National Multiprofile Transport Hospital, Sofia
city: Sofia
country: Bulgaria
facility: Diagnostic Consultative Center Alexandrovska
city: Sofia
country: Bulgaria
facility: University Multidisciplinary Hospital for Active Treatment Sveta Ekaterina EAD
city: Sofia
country: Bulgaria
facility: University Multiprofile Hospital for Active Treatement "Alexandrovska" EAD
city: Sofia
country: Bulgaria
facility: Medical Center Hera EOOD
city: Sofia
country: Bulgaria
facility: MHAT "Tsaritsa Yoanna-ISUL" Clinic of Cardiology, Sofia
city: Sofia
country: Bulgaria
facility: Multiprofile Hospital MHATEM 'Pirogov', Sofia
city: Sofia
country: Bulgaria
facility: Kalimat Medical Center Ltd.
city: Stara Zagora
country: Bulgaria
facility: Medical Center Zara-Med EOOD
city: Varna
country: Bulgaria
facility: DCC 'Chaika', EOOD, Varna
city: Yambol
country: Bulgaria
facility: MHAT St Panteleimon
city: Yambol
country: Bulgaria
facility: MHAT St Panteleimon
city: Cambridge
country: Canada
facility: Cambridge Cardiac Care Centre
state: Ontario
city: Hamilton
country: Canada
facility: Curnew Medicine Professional Corporation
state: Ontario
city: London
country: Canada
facility: St. Joseph's Health Centre (London, Ontario)
state: Ontario
city: Mississauga
country: Canada
facility: KMH Cardiology Centres (Mississauga)
state: Ontario
city: Oshawa
country: Canada
facility: James Cha, MD
state: Ontario
city: Peterborough
country: Canada
facility: Kawartha Cardiology Clinical Trials
state: Ontario
city: Sarnia
country: Canada
facility: CardioQuest Research Centre
state: Ontario
city: St Catharines
country: Canada
facility: Niagara Health System - St. Catharines Site
state: Ontario
city: Stoney Creek
country: Canada
facility: KMH Cardiology Centers (Hamilton)
state: Ontario
city: Toronto
country: Canada
facility: Diabetes Heart Research Centre
state: Ontario
city: Greenfield Park
country: Canada
facility: ViaCar Recherches Cliniques Inc. (Greenfield Park)
state: Quebec
city: Trois-Rivières
country: Canada
facility: Diex Recherche (Trois-Rivieres)
state: Quebec
city: Edmonton
country: Canada
facility: Royal Alexandra Hospital
city: Kitchener
country: Canada
facility: Clinical Research Solutions Inc. (Kitchener)
city: Montreal
country: Canada
facility: Centre Hospitalier de l'Universite de Montreal (CHUM)
city: Montreal
country: Canada
facility: Montreal General Hospital - McGill University Health Centre
city: Montreal
country: Canada
facility: CIUSSS du Centre Ouest de l'lle de Montreal
city: Oakville
country: Canada
facility: M Heffernan Medicine Professional Corp.
city: St. Jean sur Richelieu
country: Canada
facility: CardioVasc HR Inc.
city: Sudbury
country: Canada
facility: Health Sciences North
city: Puerto Varas
country: Chile
facility: Quantum Research Santiago, Puerto Varas
city: Santiago
country: Chile
facility: Sociedad Medica Cardiologica El Llano
city: Talcahuano
country: Chile
facility: Hospital Las Higueras
city: Temuco
country: Chile
facility: CECMI Ltda
city: Viña del Mar
country: Chile
facility: CINVEC - Centro de Investigacion Clinica V Reg.,Vina del Mar
city: Baotou
country: China
facility: The First Affiliated Hospital of Baotou Medical College
city: Baotou
country: China
facility: Baotou Central Hospital
city: Beijing
country: China
facility: Beijing AnZhen Hospital
city: Beijing
country: China
facility: Cardiovascular Institute and Fu Wai Hospital
city: Beijing
country: China
facility: Peking University Third Hospital
city: Changchun
country: China
facility: Jilin Province People's Hospital
city: Changchun
country: China
facility: The First Hospital of Jilin University
city: Changchun
country: China
facility: China-Japan Union Hospital of Jilin University
city: Changde City
country: China
facility: Changde Second People's Hospital
city: Changsha
country: China
facility: Changsha Central Hospital
city: Changsha
country: China
facility: The Second Xiangya Hospital Of Central South University
city: Changsha
country: China
facility: The third xiangya hospital of Central South University
city: Changsha
country: China
facility: The Third Hospital of Changsha
city: Chengdu
country: China
facility: Chengdu Second People's Hospital
city: Chengdu
country: China
facility: West China Hospital
city: Chengdu
country: China
facility: The First Affiliated Hospital of Chengdu Medical College
city: Chenzhou
country: China
facility: Chenzhou No.1 people's Hospital
city: Dalian
country: China
facility: Affiliated Zhongshan Hospital of Dalian University
city: Daqing City
country: China
facility: Daqing Oilfield General Hospital
city: Deyang
country: China
facility: People's Hospital of Deyang City
city: Foshan
country: China
facility: The First People's Hospital of Foshan
city: Fuzhou
country: China
facility: The First Affiliated Hospital of Fujian Medical University
city: Fuzhou
country: China
facility: No.900 Hospital of PLA Joint Logistics Support Force
city: Guangzhou
country: China
facility: Guangdong Provincial People's Hospital
city: Guangzhou
country: China
facility: Sun yet-sen Memorial Hospital, Sun yet-sen Univesity
city: Guangzhou
country: China
facility: Third Affiliated Hospital of Guangzhou Medical University
city: Guangzhou
country: China
facility: The First Affiliated Hospital of Guangzhou University of Chinese Medicine
city: Guangzhou
country: China
facility: The Affiliated Panyu Central Hospital of Guangzhou Medical University
city: Guiyang City
country: China
facility: The Affiliated Hospital of Guizhou Medical University
city: Guiyang
country: China
facility: Guizhou People's Hospital
city: Haikou
country: China
facility: Hainan General Hospital
city: Hangzhou
country: China
facility: Hangzhou First People's Hospital
city: Harbin
country: China
facility: The First Affiliated Hospital of Harbin Medical University
city: Huainan
country: China
facility: Huainan First People's Hospital
city: Jiangmen
country: China
facility: Jiangmen Central Hospital
city: Jinan
country: China
facility: Center Hospital of Jinan
city: Jining
country: China
facility: Jining No.1 people's hospital
city: Lanzhou
country: China
facility: The Second Affiliated Hospital of Lanzhou Medical University
city: Linfen
country: China
facility: Linfen Central Hospital
city: Luoyang
country: China
facility: The First Affiliated Hospital of Henan University of Science and Technology
city: Luoyang
country: China
facility: Luoyang Third People's Hospital
city: Nanchang City
country: China
facility: The First Affiliated Hospital of Nanchang University
city: Nanchang
country: China
facility: Jiangxi Province Integrated Tractional Chinese Medicine& Western Medicine Hospital
city: Nanjing
country: China
facility: Nanjing Drum Tower Hospital
city: Nanjing
country: China
facility: Nanjing Jiangning Hospital
city: Nanning
country: China
facility: The First Affiliated Hospital of Guangxi Medical University
city: Nanyang
country: China
facility: Nanyang Second General Hospital
city: Panjin
country: China
facility: Panjin Liao Oil Gem Flower Hospital
city: Pingxiang
country: China
facility: Pingxiang People's Hospital
city: Shanghai
country: China
facility: Zhongshan Hospital Affiliated to Fudan University
city: Shanghai
country: China
facility: Tongren hospital, Shanghai Jiaotong University School of Medicine
city: Shanghai
country: China
facility: Shanghai General Hospital
city: Shengyang
country: China
facility: Shengjing Hospital of China Medical University
city: Shenzhen
country: China
facility: Shenzhen People's Hospital
city: Tianjin
country: China
facility: Tianjin Union Medical Center Nankai University Affiliated Hospital
city: Wuhan
country: China
facility: Hubei Province Zhongshan Hospital
city: Wuhan
country: China
facility: Wuhan Puai Hospital
city: Wuhan
country: China
facility: Renmin Hospital of Wuhan University
city: XI An
country: China
facility: Shaanxi Provincial People's Hospital
city: Xiangtan
country: China
facility: Xiangtan Central Hospital
city: Xuancheng
country: China
facility: The People's Hospital Of Xuancheng City
city: Xuzhou
country: China
facility: The General Hospital of XZCMG (The Second Affiliated Hospital of Xuzhou Medical University)
city: Yanji
country: China
facility: Yanbian University Hospital
city: Yinchuan
country: China
facility: The first People's Hosptal of Yinchuan
city: Yueyang
country: China
facility: Yueyang Central Hospital
city: Yuncheng
country: China
facility: Yuncheng Central Hospital
city: Zhangjiakoou
country: China
facility: The First Affiliated Hospital of Hebei North University
city: Zhengzhou
country: China
facility: The First Affiliated Hospital of Zhengzhou University
city: Zhenjiang
country: China
facility: Affiliated Hospital of Jiangsu University
city: Armenia
country: Colombia
facility: Cardiomet CEQUIN S.A.S
city: Barranquilla
country: Colombia
facility: Centro de Investigacion Medico Asistencial S.A.S
city: Barranquilla
country: Colombia
facility: Corazon IPS S.A.S.
city: Barranquilla
country: Colombia
facility: IPS Centro Cientifico Asistencia
city: Cali
country: Colombia
facility: IPS Centro Medico Julián Coronel S.A.
city: Cartagena
country: Colombia
facility: Centro de Diagnostico Cardiologico para la Investigacion Bio
city: Floridablanca
country: Colombia
facility: Fundacion Cardiovascular de Colombia
city: Manizales
country: Colombia
facility: IPS médicos internistas de Caldas S.A.S.
city: Santa Marta
country: Colombia
facility: T Y C Inversiones S A S Grupsalud
city: Zipaquirá
country: Colombia
facility: Healthy Medical CenterS.A.S, Zipaquirá
city: Bilovec
country: Czechia
facility: Poliklinika Humanitas
city: Brandys nad Labem
country: Czechia
facility: Medicus Services Ltd.
city: Brandýs nad Labem
country: Czechia
facility: Interni Ordinace s.r.o.
city: Brno
country: Czechia
facility: University Hospital at St. Anna
city: Brno
country: Czechia
facility: Internal and Cardiology Practice, MUDr. Karel Kamenik, Brno
city: Brno
country: Czechia
facility: University Hospital Brno
city: Brno
country: Czechia
facility: Vojenska nemocnice Brno
city: Chrudim
country: Czechia
facility: MUDr. Jan Hubac, s.r.o. Kardiologicka ambulance
city: Havlickuv Brod
country: Czechia
facility: Regional Hospital Havlickuv Brod
city: Jablonec nad Nisou
country: Czechia
facility: Kardiologie KarMa s.r.o
city: Jihlava
country: Czechia
facility: Hospital Jihlava
city: Litovel
country: Czechia
facility: MUDr Petra Maskova PhD
city: Marianske Lazne
country: Czechia
facility: InterKardioML s.r.o.
city: Prague 10
country: Czechia
facility: Cardiology and Angiology Private Practice
city: Prag
country: Czechia
facility: University Hospital Motol
city: Praha 1
country: Czechia
facility: Kardiologie Vinohrady s r o
city: Praha 4-Krc
country: Czechia
facility: Thomayer University Hospital
city: Praha 4
country: Czechia
facility: Institute for Clinical and Experimental Medicine -Praha 4-58982
city: Smirice
country: Czechia
facility: Internist Care s r o
city: Trutnov
country: Czechia
facility: Kardiologicka ambulance MUDr. Ferkl s.r.o.
city: Uherske Hradiste
country: Czechia
facility: Clinical Trials Services s.r.o
city: Uherske Hradiste
country: Czechia
facility: MUDr. Nina Zemkova s.r.o.
city: Zlin
country: Czechia
facility: Cardio Research s.r.o.
city: Aachen
country: Germany
facility: Universitätsklinikum Aachen, AöR
city: Bad Friedrichshall
country: Germany
facility: SLK-Kliniken Heilbronn GmbH
city: Berlin
country: Germany
facility: Charite Universitätsmedizin Berlin KöR
city: Berlin
country: Germany
facility: Praxis Dr. Rieker, Berlin
city: Berlin
country: Germany
facility: Charite Universitätsmedizin Berlin KöR
city: Berlin
country: Germany
facility: Praxis Dr. Toursarkissian, 13347 Berlin
city: Berlin
country: Germany
facility: Vivantes Netzwerk für Gesundheit GmbH
city: Bonn
country: Germany
facility: Universitätsklinikum Bonn AöR
city: Dessau-Roßlau
country: Germany
facility: Praxis Dr. Menzel
city: Dresden
country: Germany
facility: Städtisches Klinikum Dresden
city: Erfurt
country: Germany
facility: Helios Klinikum Erfurt
city: Frankfurt
country: Germany
facility: ClinPhenomics CVC GmbH
city: Hannover
country: Germany
facility: Medizinische Hochschule Hannover
city: Jena
country: Germany
facility: Universitätsklinikum Jena
city: Kamp-Lintfort
country: Germany
facility: Praxis Joachim Heisters
city: Langen
country: Germany
facility: Asklepios Klinik Langen-Seligenstadt GmbH
city: Lüneburg
country: Germany
facility: Praxis Dr. Sarnighausen, Lüneburg
city: Neuwied
country: Germany
facility: Marienhaus Klinikum St. Elisabeth, Neuwied
city: Nürnberg
country: Germany
facility: Gemeinschaftspraxis Dres Haggenmiller/Jeserich
city: Papenburg
country: Germany
facility: Dr. Andreas Wilke Dr. Andrej Malazhavy und Detelin Lalev Denchev Fachaerzte Innere Medizin und Kardiologie Partnerschaft
city: Regensburg
country: Germany
facility: Universitätsklinikum Regensburg
city: Stuhr
country: Germany
facility: Gemeinschaftspraxis Stuhr-Brinkum
city: Wallerfing
country: Germany
facility: Praxis Dr. Großkopf Wilma, Wallerfing
city: Wermsdorf
country: Germany
facility: Kardiologische Praxis, Wermsdorf
city: Baja
country: Hungary
facility: Lausmed Kft. Outpatient Unit of Internal Medicine
city: Budapest
country: Hungary
facility: Buda Hospital of the Hospitaller Order of Saint John of God
city: Budapest
country: Hungary
facility: Obuda Health Center
city: Budapest
country: Hungary
facility: Belvaros-Lipotvaros Egeszsegugyi Szolgalat
city: Budapest
country: Hungary
facility: Semmelweis University
city: Budapest
country: Hungary
facility: Gottsegen National Cardiovascular Center
city: Budapest
country: Hungary
facility: Semmelweis University
city: Budapest
country: Hungary
facility: Privat Doktor Egeszseguegyi Szolgaltato Zrt.
city: Budapest
country: Hungary
facility: UNO Medical Trials Kft.
city: Gyula
country: Hungary
facility: Bekes Varmegyei Koezponti Korhaz
city: Hatvan
country: Hungary
facility: BKS Research Ltd
city: Miskolc
country: Hungary
facility: Borsod-Abauj-Zemplen Megyei Korhaz es Egyetemi Oktato Korhaz
city: Miskolc
country: Hungary
facility: IPR Hungary Kft.
city: Oroshaza
country: Hungary
facility: Dr. Nagy Laszlo Kardiologiai Maganrendeles
city: Pecs
country: Hungary
facility: Coromed-Smo Kft.
city: Pecs
country: Hungary
facility: Pecsi Tudomanyegyetem
city: Pecs
country: Hungary
facility: Da Vinci Private Clinic
city: Szeged
country: Hungary
facility: Ujszeged Egeszsegkozpont Diabetes Centrum
city: Szekszard
country: Hungary
facility: Tolna County Balassa Janos Hospital
city: Szolnok
country: Hungary
facility: Jasz-Nagykun-Szolnok Megyei Hetenyi G. Korhaz-Rendelointezet
city: Zalaegerszeg
country: Hungary
facility: Belvarosi Egeszseghaz Kft.
city: Aurangabad
country: India
facility: Kamalnayan Bajaj Hospital
city: Bangalore
country: India
facility: Narayana Institute of Cardiac Sciences
city: Bengaluru
country: India
facility: Bangalore Medical college
city: Bikaner
country: India
facility: S.P. Medical College & Associated Group of Hospitals
city: Chennai
country: India
facility: Tamil Nadu Government Multi Super Speciality Hospital TNGMSSH
city: Chennai
country: India
facility: Apollo Main Hospital
city: Gurgaon
country: India
facility: Medanta-The Medicity
city: Guwahati
country: India
facility: GNRC Hospital
city: Kolkata
country: India
facility: IPGMER and SSKM Hospital
city: New Delhi
country: India
facility: Max Super Speciality Hospital, Delhi
city: Vishakhapatnam
country: India
facility: King George Hospital
city: Bergamo
country: Italy
facility: Humanitas Gavazzeni
city: Bergamo
country: Italy
facility: ASST Papa Giovanni XXIII
city: Foggia
country: Italy
facility: Az.Osp. Universitaria "Ospedali Riuniti"
city: Genova
country: Italy
facility: Azienda Ospedaliera San Martino
city: Napoli
country: Italy
facility: Azienda Ospedaliera Universitaria "Federico II"
city: Pavia
country: Italy
facility: Fondazione IRCCS Policlinico S. Matteo
city: Roma
country: Italy
facility: Azienda Ospedaliera Sant'Andrea-Università di Roma La Sapienza
city: Rozzano
country: Italy
facility: Istituto Clinico Humanitas
city: Aichi, Kasugai
country: Japan
facility: Kasugai Municipal Hospital
city: Azumino-shi
country: Japan
facility: Azumino Red Cross Hospital
city: Chiba, Chiba
country: Japan
facility: Chiba Heart Clinic
city: Chuo-Ku
country: Japan
facility: Tokyo-Eki Center-building Clinic
city: Fukuoka, Kitakyushu
country: Japan
facility: Kokura Memorial Hospital
city: Hamada-shi
country: Japan
facility: National Hospital Organization Hamada Medical Center
city: Higashiibaraki-gun
country: Japan
facility: Mito Medical Center
city: Himeji-shi
country: Japan
facility: Hyogo Prefectural Harima-Himeji General Medical Center
city: Hokkaido, Sapporo
country: Japan
facility: Matsuda Cardiovascular Clinic
city: Hokkaido, Tomakomai
country: Japan
facility: Oji General Hospital
city: Hyogo, Amagasaki
country: Japan
facility: Hyogo Prefectural Amagasaki General Medical Center
city: Ishikawa, Kanazawa
country: Japan
facility: National Hospital Organization Kanazawa Medical Center
city: Iwakuni-shi
country: Japan
facility: National Hospital Organization Iwakuni Clinical Center
city: Kagawa, Takamatsu
country: Japan
facility: Kagawa Prefectural Central Hospital
city: Kamakura-shi
country: Japan
facility: Tokushukai Shonan Kamakura General Hospital
city: Kanagawa, Miura-gun
country: Japan
facility: Tokushukai Hayama Heart Center
city: Kanagawa, Yokohama
country: Japan
facility: Kanagawa Cardiovascular and Respiratory Center
city: Kanagawa, Yokohama
country: Japan
facility: Yokohama Sakae Kyosai Hospital
city: Kanonji-shi
country: Japan
facility: Mitoyo General Hospital
city: Kishiwada-shi
country: Japan
facility: Tokushukai Kishiwada Tokushukai Hospital
city: Kitaazumi-gun
country: Japan
facility: North Alps Medical Center Azumi Hospital
city: Kobe-shi
country: Japan
facility: National Hospital Organization Kobe Medical Center
city: Matsumoto-shi
country: Japan
facility: Shinshu University Hospital
city: Matsuyama-shi
country: Japan
facility: Ehime Prefectural Central Hospital
city: Matsuyama-shi
country: Japan
facility: Matsuyama Shimin Hospital
city: Mito-shi
country: Japan
facility: Mito Saiseikai General Hospital
city: Nakano-shi
country: Japan
facility: Hokushin General Hospital
city: Oita, Oita
country: Japan
facility: Oita Medical Center
city: Okayama-shi
country: Japan
facility: Okayama City General Medical Center
city: Okinawa, Naha
country: Japan
facility: Naha City Hospital
city: Okinawa, Urasoe
country: Japan
facility: Urasoe General Hospital
city: Osaka, Osaka
country: Japan
facility: Kitano Hospital
city: Osaka, Osaka
country: Japan
facility: Osaka Keisatsu Hospital
city: Osaka, Osaka
country: Japan
facility: Nippon Life Hospital
city: Osaka, Osaka
country: Japan
facility: Japan Community Health care Organization Osaka Hospital
city: Osaka, Osaka
country: Japan
facility: Osaka General Medical Center
city: Saga-shi
country: Japan
facility: Saga-Ken Medical Centre Koseikan
city: Saitama-shi
country: Japan
facility: Sainokuni Higashiomiya Medical Center
city: Saitama-shi
country: Japan
facility: San-Ai Hospital
city: Sendai-shi
country: Japan
facility: NHO Sendai Medical Center
city: Suita-shi
country: Japan
facility: The University of Osaka Hospital
city: Tokushima-shi
country: Japan
facility: Tokushima Prefectural Central Hospital
city: Tokyo, Ome
country: Japan
facility: Ome Municipal General Hospital
city: Tomakomai-shi
country: Japan
facility: Tomakomai City Hospital
city: Busan
country: Korea, Republic of
facility: Inje University Busan Paik Hospital
city: Busan
country: Korea, Republic of
facility: Dong-A University Hospital
city: Busan
country: Korea, Republic of
facility: Pusan National Univ. Hosp
city: Gwangju
country: Korea, Republic of
facility: Chonnam National University Hospital
city: Incheon
country: Korea, Republic of
facility: Gachon University Gil Medical Center
city: Seongnam
country: Korea, Republic of
facility: Seoul National University Bundang Hospital
city: Seoul
country: Korea, Republic of
facility: Seoul National University Hospital
city: Seoul
country: Korea, Republic of
facility: Severance Hospital
city: Seoul
country: Korea, Republic of
facility: Samsung Medical Center
city: Seoul
country: Korea, Republic of
facility: Korea University Guro Hospital
city: Wonju-si, Gangwon State
country: Korea, Republic of
facility: Yonsei University Wonju Severance Christian Hospital
city: Aguascalientes
country: Mexico
facility: Fundación Cardiovascular de Aguascalientes A.C
city: Aguascalientes
country: Mexico
facility: Hospital Cardiologica Aguascalientes
city: Culiacan
country: Mexico
facility: Centro Especializado de Investigación Medical Group Culiacan
city: Culiacan
country: Mexico
facility: Centro para el Desarrollo de la Medicina y de Asistencia Medica Especializada S.C.
city: Distrito Federal
country: Mexico
facility: Centro de Investigacion Biomedica y Farmaceutica, S.C.
city: Guadalajara
country: Mexico
facility: CICEJ Centro de Investigacion Clinica Endocrinologica de Jalisco S.C.
city: Guadalajara
country: Mexico
facility: Salud Cardiovascular
city: Irapuato
country: Mexico
facility: Proactive CR Mexico S.A. de C.V.
city: Mazatlan
country: Mexico
facility: Centro de Estudios de Alta Especialidad de Sinaloa CEAES
city: Monterrey
country: Mexico
facility: Cardiolink Clin Trials S.C.
city: Monterrey
country: Mexico
facility: Hospital Universitario Dr Jose Eleuterio Gonzalez
city: México
country: Mexico
facility: Clinstile S.A. de C.V.
city: Tlalnepantla
country: Mexico
facility: Clinical Research Institute S.C.
city: Torreon
country: Mexico
facility: Centro de Investigacion Medica Alberto Bazzoni S.A. de C.V.
city: Arnhem
country: Netherlands
facility: Rijnstate Hospital
city: Breda
country: Netherlands
facility: Amphia Ziekenhuis
city: Deventer
country: Netherlands
facility: Deventer Ziekenhuis
city: Eindhoven
country: Netherlands
facility: Catharina Ziekenhuis
city: Gouda
country: Netherlands
facility: Groene Hart ziekenhuis
city: Leiderdorp
country: Netherlands
facility: Alrijne Leiderdorp
city: Nieuwegein
country: Netherlands
facility: St. Antonius ziekenhuis, locatie Nieuwegein
city: Rotterdam
country: Netherlands
facility: Ikazia Ziekenhuis
city: s Hertogenbosch
country: Netherlands
facility: Jeroen Bosch Ziekenhuis-Hertogenbosch
city: Zaandam
country: Netherlands
facility: De Heel - Zaans Medisch Centrum
city: Bialystok
country: Poland
facility: Univ. Clinic Hosp, Bialystok
city: Bydgoszcz
country: Poland
facility: INTERCORE Medical Center
city: Bydgoszcz
country: Poland
facility: NZOZ Medical Center KERmed
city: Gdansk
country: Poland
facility: Poradnia Kardiologiczna Jaroslaw Jurowiecki
city: Gdynia
country: Poland
facility: Individual Specialist Medical Practice Krzysztof Cymerman
city: Katowice
country: Poland
facility: Pratia Katowice Medical Center
city: Katowice
country: Poland
facility: Clinical Medical Research Sp. z o.o.
city: Kielce
country: Poland
facility: Specialistic Cardiology&Hypertension Out-patient Clin,Kielce
city: Krakow
country: Poland
facility: Leszek Bryniarski Specialized Medical Cabinet
city: Kraków
country: Poland
facility: Linden Sp. z o.o. sp.k.
city: Legnica
country: Poland
facility: Beata Miklaszewicz & Dariusz Dabrowski Cardiamed Sp. j.
city: Lodz
country: Poland
facility: SANTA FAMILIA Centrum Badan, Profilaktyki i Leczenia
city: Lodz
country: Poland
facility: Individual Specialized Practice
city: Lowicz
country: Poland
facility: Lowickie Cardiology Center
city: Lublin
country: Poland
facility: Velocity Lublin
city: Lublin
country: Poland
facility: Zanamed Medical Clinic Sp. z o.o.
city: Olsztyn
country: Poland
facility: Medeusz-Plus
city: Oswiecim
country: Poland
facility: Medicome Sp. z o.o.
city: Piaseczno
country: Poland
facility: NZOZ HEUREKA, Piaseczno
city: Poznan
country: Poland
facility: Non-Public Outpatient Clinic Neuro-Kard Ilkowski & Partners
city: Ruda Slaska
country: Poland
facility: Aka-Med Centrum Sp. z o.o. S.K.
city: Rzeszow
country: Poland
facility: MEDYK Medical Center
city: Siedlce
country: Poland
facility: Lukmed Lukasz Wozniak
city: Skierniewice
country: Poland
facility: Velocity Skierniewice Sp. z o.o
city: Sochaczew
country: Poland
facility: RCMed- Regionalne Centrum Medyczne
city: Sopot
country: Poland
facility: NZOZ Procordis, Cardiology Research Center of Sopot
city: Staszow
country: Poland
facility: Velocity Staszow
city: Warsaw
country: Poland
facility: FutureMeds Sp. z o.o.
city: Warszawa
country: Poland
facility: Balsammedica Sp. z o. o.
city: Wroclaw
country: Poland
facility: 4. Military Clinical Hospital with Polyclinic SP ZOZ
city: Wroclaw
country: Poland
facility: Sedimed Sp. z o.o.
city: Zamosc
country: Poland
facility: KO-MED Clinical Centers Zamosc
city: Zarow
country: Poland
facility: NZOZ Centrum Medyczne SERAFIN-MED Halina Serafin
city: Balotesti
country: Romania
facility: Spitalul Clinic De Urgenta Prof Dr Agrippa Ionescu
city: Braila
country: Romania
facility: Spitalul Judetean de Urgenta Braila
city: Brasov
country: Romania
facility: S.C.Centrul Medical Unirea SRL
city: Bucharest
country: Romania
facility: S.C. Policlinica CCBR S.R.L.
city: Bucharest
country: Romania
facility: Emergency University Hospital, Bucharest
city: Bucuresti
country: Romania
facility: Clinica Medicala Data Plus SRL
city: Cluj-Napoca
country: Romania
facility: Spitalul Angiocare SRL
city: Iasi
country: Romania
facility: S.C.Centrul Medical Unirea S.R.L.
city: Pitesti
country: Romania
facility: Sal Med Srl
city: Targu Mures
country: Romania
facility: Cmi Dr. Podoleanu Cristian
city: Targu-Mures
country: Romania
facility: Country Clinical Emergency Hospital, Targu-Mures
city: Timisoara
country: Romania
facility: S.C Medicali's S.R.L
city: Jeddah
country: Saudi Arabia
facility: King AbdulAziz University Hospital
city: Riyadh
country: Saudi Arabia
facility: King Faisal Specialist Hospital and Research Center
city: Riyadh
country: Saudi Arabia
facility: King Abdulaziz Medical City
city: Riyadh
country: Saudi Arabia
facility: King Fahad Medical City
city: Riyadh
country: Saudi Arabia
facility: King Saud Medical City
city: Belgrade
country: Serbia
facility: Clinical Hospital Center Dr. Dragisa Misovic
city: Belgrade
country: Serbia
facility: Institute for Cardiovascular diseases Dedinje
city: Belgrade
country: Serbia
facility: University Clinical Center of Serbia
city: Belgrade
country: Serbia
facility: Clinical Hospital Center Zemun
city: Kragujevac
country: Serbia
facility: University Clinical Center of Kragujevac
city: Niska Banja
country: Serbia
facility: Institute for Treatment and Rehabilitation, Niska Banja
city: Nis
country: Serbia
facility: University Clinical Center Nis
city: Pancevo
country: Serbia
facility: General Hospital Pancevo
city: Smederevo
country: Serbia
facility: General Hospital Sveti Luka
city: Zajecar
country: Serbia
facility: Health Centre Zajecar
city: Celje
country: Slovenia
facility: General Hospital Celje
city: Golnik
country: Slovenia
facility: University Hospital Golnik
city: Jesenice
country: Slovenia
facility: General Hospital Jesenice
city: Ljubljana
country: Slovenia
facility: University Medical Center Ljubljana
city: Murska Sobota
country: Slovenia
facility: General Hospital Murska Sobota
city: Trbovlje
country: Slovenia
facility: General Hospital Trbovlje
city: Bloemfontein
country: South Africa
facility: Iatros International
city: Bloemfontein
country: South Africa
facility: Josha Research Centre
city: Cape Town
country: South Africa
facility: TREAD Research
city: Centurion
country: South Africa
facility: Badenhorst, JCW
city: Johannesburg
country: South Africa
facility: Chris Hani Baragwanath Hospital: Cardiology Department
city: Somerset West
country: South Africa
facility: Dr JM Engelbrecht
city: Worcester
country: South Africa
facility: Clinical Projects Research
city: Barcelona
country: Spain
facility: Hospital Quiron. I.C.U.
city: El Palmar
country: Spain
facility: Hospital Universitario Virgen de la Arrixaca
city: Madrid
country: Spain
facility: Hospital General Universitario Gregorio Marañón
city: Madrid
country: Spain
facility: Hospital Universitario 12 de Octubre
city: Madrid
country: Spain
facility: Hospital La Paz
city: Malaga
country: Spain
facility: Hospital Virgen de la Victoria
city: Sanlúcar de Barrameda
country: Spain
facility: Hospital Virgen del Camino
city: Santiago de Compostela
country: Spain
facility: Complexo Hospitalario Universitario De Santiago
city: Valencia
country: Spain
facility: Hospital Clínico de Valencia
city: Valencia
country: Spain
facility: Hospital General Universitario de Valencia
city: Valencia
country: Spain
facility: Hospital Politècnic La Fe
city: Villamartin, Cardiz
country: Spain
facility: Hospital Virgen de las Montañas, Villamartin
city: Kaohsiung
country: Taiwan
facility: Kaohsiung Medical University Chung-Ho Memorial Hospital
city: Kaohsiung
country: Taiwan
facility: E-Da Hospital
city: New Taipei City
country: Taiwan
facility: Far Eastern Memorial Hospital
city: Taichung
country: Taiwan
facility: China Medical University Hospital
city: Taichung
country: Taiwan
facility: Taichung Veterans General Hospital
city: Taipei City
country: Taiwan
facility: Taipei Medical University Hospital
city: Taipei
country: Taiwan
facility: National Taiwan University Hospital
city: Taipei
country: Taiwan
facility: Taipei Veterans General Hospital
city: Taipei
country: Taiwan
facility: Cheng Hsin General Hospital
city: Taoyuan County
country: Taiwan
facility: Chang Gung Memorial Hospital(Linkou)
city: Adana
country: Turkey
facility: Çukurova Ü. Tip Fak., Balcali Hastanesi, Kardiyoloji
city: Afyon
country: Turkey
facility: Afyon Kocatepe University Medical Faculty
city: Ankara
country: Turkey
facility: Etlik City Hospital
city: Elazıg
country: Turkey
facility: Firat University Hospital
city: Erzurum
country: Turkey
facility: Ataturk Universitesi Tip Fakultesi
city: Eskisehir
country: Turkey
facility: Osmangazi Universitesi Tip Fakultesi Gögüs Hast. ABD
city: Gaziantep
country: Turkey
facility: Gaziantep University Medical Faculty Sahinbey Educational Research Hospital
city: Istanbul
country: Turkey
facility: Siyami Ersek Gogus Kalp ve Damar Cerrahisi Hastanesi
city: Istanbul
country: Turkey
facility: Medical Park Pendik Hospital
city: Izmir
country: Turkey
facility: Dokuz Eylul University Faculty of Medicine
city: Kutahya
country: Turkey
facility: Kutahya Health Science University Evliya Celebi Research and Training Hospital
city: Malatya
country: Turkey
facility: Inonu Universitesi Tip Fakultesi Gogus Hastaliklari ABD
city: Mersin
country: Turkey
facility: Mersin University Medical Faculty
city: Pendik/ Istanbul
country: Turkey
facility: Marmara Universitesi Pendik Egitim ve Arastirma Hastanesi
city: Trabzon
country: Turkey
facility: KTU Tip Fakultesi Farabi Hastanesi
city: Barnet
country: United Kingdom
facility: Barnet Hospital
city: Bristol
country: United Kingdom
facility: Southmead Hospital
city: Exeter
country: United Kingdom
facility: Royal Devon and Exeter Hospital, Wonford
city: Halifax
country: United Kingdom
facility: Calderdale Royal Hospital
city: London
country: United Kingdom
facility: St Bartholomew's Hospital
city: Oldham
country: United Kingdom
facility: The Royal Oldham Hospital
city: Sheffield
country: United Kingdom
facility: Northern General Hospital
city: Truro
country: United Kingdom
facility: Royal Cornwall Hospital
city: York
country: United Kingdom
facility: York and Scarborough Teaching Hospitals NHS Foundation Trust York Hospital
city: Hanoi
country: Vietnam
facility: Bach Mai hospital
city: Ho Chi Minh City
country: Vietnam
facility: Cho Ray Hospital
city: Ho Chi Minh City
country: Vietnam
facility: Nguyen Tri Phuong Hospital
city: Ho Chi Minh
country: Vietnam
facility: Tam Duc Heart Hospital
city: Ho Chi Minh
country: Vietnam
facility: Thong Nhat Hospital HCMC
Study officials:
References: