Clinical trial NCT05019885: The Efficacy of a Subanesthetic Doses of IV Ketamine in the Treatment Drug Resistant Epilepsy
Official title: A Pilot Study to Assess the Efficacy of Subanesthetic Doses of IV Ketamine in the Treatment Drug Resistant Epilepsy
Study type: INTERVENTIONAL
Overall status: RECRUITING
Phase: PHASE2
Conditions: Drug Resistant Epilepsy
Medically Refractory Epilepsy
Refractory Epilepsy
Keywords: drug resistant epilepsy
subanesthetic Ketamine hydrochloride
Lead sponsor: Icahn School of Medicine at Mount Sinai
Sponsor class: OTHER
First posted: 2021-08-25
Enrollment: 9
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Intervention model description: Experimental clinical treatment
Primary purpose: TREATMENT

Brief summary: Ketamine is a medication that came into clinical practice in the 1960's. Ketamine is used as an anesthetic and to provide pain relief. Recently, Ketamine was approved to treat drug resistant depression using subanesthetic doses. In the hospital setting, intravenous anesthetic dosages are used to treat unrelenting seizures known as status epilepticus in comatose patients. Ketamine in subanesthetic doses has not been tried as a treatment for medication resistant seizures in the outpatient setting. This study would like to examine the effectiveness of subanesthetic ketamine in outpatients who suffer from drug resistant epilepsy.

Detailed description: This is an open label pilot study that will evaluate the effectiveness of a sub-anaesthetic dose (0.5mg/kg) of IV Ketamine in Drug Resistant Epilepsy Patients. Mood assessments will also be administered. The study consists of 3 phases:

Screening : Seizure diary will be prospectively filled for 4 weeks and subjects must have at least 4 seizures in 28 days to proceed to the treatment phase. Baseline mood assessment will be performed (NDDI-E, QOLIE-10, GAD 7 )

Treatment Phase: This phase will consist of 6 study visits (3 visits/ week for 2 weeks). Patients will receive 0.5mg/kg Racemic ketamine IV over 40 min three times a week (M, W, F) for 2 consecutive weeks.

Treatment Visit 1: Monday Week 5(baseline seizures diary collected) Treatment Visit 2: Wednesday Week 5 Treatment Visit 3: Friday Week 5 Treatment Visit 4: Monday Week 6 Treatment Visit 5: Wednesday Week 6 Treatment Visit 6: Friday Week 6 (Mood assessments performed prior to infusion)

Post- Treatment Phase : This phase will consist of 5 post infusion safety assessments and 3 post-treatment assessments.

Post-Infusion Safety Assessment 1: Saturday Week 6 (Adverse Event Assessment) Post-Infusion Safety Assessment 2: Sunday Week 7 (Adverse Event Assessment) Post-Infusion Safety Assessment 3: Monday Week 7 (Adverse Event Assessment) Post-Infusion Safety Assessment 4: Monday Week 8 (Adverse Event Assessment) Post-Infusion Safety Assessment 5: Monday Week 9 (Adverse Event Assessment)

Post-Treatment Assessment 1: phone call week 10 (Seizure diary collection, mood assessments performed) Post-Treatment Assessment 2: phone call week 14 (Seizure diary) Post-Treatment Assessment 3: phone call week 18 (Seizure diary collection, mood assessments performed)

Eligibility criteria: Inclusion Criteria:

* Provision of signed and dated informed consent form
* Adults (18 years or older)
* Cognitively impaired adults are not excluded (i.e. will be included in the study)
* Established diagnosis of Drug Resistant Epilepsy (DRE) i.e. failed two or more appropriately chosen anti-seizure medications (ASMs)
* EEG consistent with focal or generalized epilepsy
* Patients must have \>4 focal aware, focal impaired aware, focal to bilateral tonic clonic or generalized tonic clonic seizures per month.
* Patients can be on \>/= 1 anti-seizure medication (ASM) at the time of enrollment on stable doses 12 weeks prior to initiation
* Patients on Epilepsy devices: Vagal nerve stimulator (VNS), Deep brain stimulator (DBS) or Responsive Nerve Stimulator (RNS) must have remained stable for at least 4 weeks before the screening visit. Adjustment of devices is not allowed during the study.

Exclusion Criteria

* Patients \<18 years of age
* Pregnant women
* Women that are breast feeding
* Patients who had \>21 days of seizure freedom in the last year.
* Patients with a history of status epilepticus within 3 months of screening
* Patients with a history of alcoholism of drug misuse within the last 2 years
* Unstable medical illness
* Serious or imminent suicidal or homicidal risk
* Patients with cardiovascular disease
* Patients with schizophrenia
* Patients with history of aneurysm or aortic dissection, arteriovenous malformation and intracerebral hemorrhage
* Patients that are immobile i.e. wheel chair bound, bed ridden individuals
* Patients on psychostimulants (amphetamines, methylphenidate etc.) and Monoamine oxidase inhibitors (selegiline, isocarboxazid, phenelzine etc.)

Primary outcomes:
measure: Number of participants with seizure reduction
timeFrame: 2 week during active treatment
measure: Number of participants with seizure reduction
timeFrame: 28 days post infusion
measure: Seizure frequency
timeFrame: 3 months post infusion
Secondary outcomes:
measure: Neurological Disorders Depression Inventory for Epilepsy (NDDI-E) Score
timeFrame: Week 6
measure: Neurological Disorders Depression Inventory for Epilepsy (NDDI-E) Score
timeFrame: Week 10
measure: Neurological Disorders Depression Inventory for Epilepsy (NDDI-E) Score
timeFrame: Week 14
measure: Neurological Disorders Depression Inventory for Epilepsy (NDDI-E) Score
timeFrame: Week 18
measure: Quality of Life in Epilepsy (QOLIE-10)
timeFrame: Week 6
measure: Quality of Life in Epilepsy (QOLIE-10)
timeFrame: Week 10
measure: Quality of Life in Epilepsy (QOLIE-10)
timeFrame: Week 14
measure: Quality of Life in Epilepsy (QOLIE-10)
timeFrame: Week 18
measure: General Anxiety Disorder 7-item questionnaire (GAD-7)
timeFrame: week 6
measure: General Anxiety Disorder 7-item questionnaire (GAD-7)
timeFrame: week 10
measure: General Anxiety Disorder 7-item questionnaire (GAD-7)
timeFrame: week 14
measure: General Anxiety Disorder 7-item questionnaire (GAD-7)
timeFrame: week 18
Other outcomes:
Locations:
city: New York
country: United States
facility: Mount Sinai Hospital
state: New York
Study officials:
affiliation: Icahn School of Medicine
name: Madeline Fields, MD
role: PRINCIPAL_INVESTIGATOR
affiliation: Icahn School of Medicine
name: Lara Marcuse, MD
role: PRINCIPAL_INVESTIGATOR
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