Clinical trial NCT05473052: Home-based Exercise Training for Lung Cancer Patients Awaiting Surgery
Official title: Home-based Preoperative Exercise Training for Lung Cancer Patients Undergoing Surgery: A Feasibility Trial
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Lung Neoplasm
Lead sponsor: Instituto Politécnico de Leiria
Sponsor class: OTHER
First posted: 2022-07-25
Enrollment: 15
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: SUPPORTIVE_CARE

Brief summary: Surgical resection is the only curative treatment in patients diagnosed with lung cancer, the most mortal type of malignancy globally. However, following lung cancer resection, patients experience a substantial deterioration in health-related quality of life and have an increased risk of developing pulmonary complications.

Although current clinical guidelines strongly recommend preoperative exercise training to improve clinical outcomes after lung cancer surgery, inaccessibility to facility-based exercise programs is a major barrier to routine participation, with patients indicating a strong preference to exercise in a home-based environment.

The primary purpose of the present study was to evaluate the feasibility of a home-based exercise program (HBEP) in lung cancer patients awaiting surgical treatment. The secondary purposes were to evaluate the safety of the HBEP and to explore exercise effects on patients' HRQOL and physical performance, either pre-and post-surgery.


Eligibility criteria: Inclusion Criteria:

* Scheduled for surgical treatment of suspected or confirmed lung cancer (clinical stage IIIA or less)
* Waiting time for surgery of at least two weeks from baseline assessment
* Medical clearance to exercise.
* Signed informed consent prior to initiation of study-related procedures.

Exclusion Criteria:

* Metastatic cancer
* Presence of physical or mental disabilities that contraindicated exercise training or physical testing
* Unable to communicate in Portuguese or English
* Performing combined aerobic plus resistance training over the past month (self-reported ≥2 days a week, ≥30 minutes each session).

Primary outcomes:
measure: Recruitment rate
timeFrame: Baseline
measure: Retention rate
timeFrame: Baseline to 4-5 weeks after surgery
measure: Exercise attendance rate
timeFrame: Baseline to 2-3 days before surgery
measure: Exercise compliance rate
timeFrame: Baseline to 2-3 days before surgery
Secondary outcomes:
measure: Adverse events
timeFrame: Baseline to 2-3 days before surgery
measure: Changes in exercise capacity
timeFrame: Baseline to 2-3 days before surgery
measure: Changes in exercise capacity
timeFrame: Baseline to 4-5 weeks after surgery.
measure: Changes in health-related quality of life
timeFrame: Baseline to 2-3 days before surgery
measure: Changes in health-related quality of life
timeFrame: Baseline to 4-5 weeks after surgery
measure: Changes in handgrip strength
timeFrame: Baseline to 2-3 days before surgery
measure: Changes in handgrip strength
timeFrame: Baseline to 4-5 weeks after surgery
measure: Changes in five times sit to stand test
timeFrame: Baseline to 2-3 days before surgery
measure: Changes in five times sit to stand test
timeFrame: Baseline to 4-5 weeks after surgery
Other outcomes:
Locations:
city: Coimbra
country: Portugal
facility: Portuguese Oncology Institute of Coimbra
Study officials:
References: