Clinical trial NCT06711341: Comparing Exercise Programs for Managing Knee Osteoarthritis
Official title: Investigating The Most Effective Exercise Modality in Knee Osteoarthritis; A RCT
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Knee OA
Osteoarthritis
Osteoarthritis (OA) of the Knee
Keywords: Exercise
Knee Osteoarthritis
Pain
Strength
Whole-Body Vibration
Lead sponsor: Uludag University
Sponsor class: OTHER
Collaborators: name: Uludag University Hospital
First posted: 2024-12-02
Enrollment: 69
Sex: ALL
Minimum age (years): 45
Maximum age (years): 70
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The goal of this clinical trial is to assess and compare the effectiveness of three different exercise modalities-whole-body vibration exercise, progressive resistance exercise, and home-based exercise -in improving quadriceps isometric muscle strength, physical function, balance, knee pain, osteoarthritis symptoms, and overall quality of life in individuals with knee osteoarthritis.

The main questions it aims to answer are:

* How do WBV, PRE, and home-based exercise compare in improving quadriceps strength in people with knee osteoarthritis?
* Which exercise modality leads to the greatest improvements in physical function, balance, knee pain, and quality of life?

Researchers will compare the three exercise regimens to determine which is most effective for improving knee function and relieving osteoarthritis symptoms.

Participants will:

* Engage in whole-body vibration exercise, progressive resistance exercise, or home-based exercise for 3 weeks.
* Undergo assessments before and at the end of the exercise program, including tests for physical function and balance (Timed Up and Go Test, 5x Sit to Stand Test) and questionnaires to evaluate knee osteoarthritis symptoms (WOMAC), quality of life (SF-36), and self-reported knee pain (Numeric Rating Scale).


Eligibility criteria: Inclusion Criteria:

1. participants between the ages of 45-70,
2. diagnosed with knee osteoarthritis according to ACR criteria (unilateral or bilateral),
3. having grade 2 or 3 tibiofemoral knee osteoarthritis according to Kellgren-Lawrence staging,
4. having knee pain due to OA for a minimum of 3 months prior to enrollment,
5. patients whose medical treatment is not expected to change during the study period.

Exclusion Criteria:

1. having or had undergone knee surgery,
2. patients unable to walk without support,
3. having musculoskeletal limitations that prevent participation in resistance exercises (contracture, fracture, etc.),
4. other neurological, cardiac, respiratory and systemic diseases that will affect physical activity,
5. currently implementing a regular exercise or physical therapy program specific to knee OA

Primary outcomes:
measure: Quadriceps Isometric Muscle Strength
timeFrame: at baseline and 3-weeks
Secondary outcomes:
measure: Timed Up and Go (TUG) Test (Physical Function and Balance)
timeFrame: at baseline and 3-weeks
measure: Five Times Sit to Stand Test (5xSST) (Physical Function and Balance)
timeFrame: at baseline and 3-weeks
measure: Numeric Rating Scale (NRS) (Self-reported Knee Pain)
timeFrame: at baseline and 3-weeks
measure: WOMAC (Knee Osteoarthritis Symptoms and Function)
timeFrame: at baseline and 3-weeks
measure: SF-36 (Quality of Life)
timeFrame: at baseline and 3-weeks
Other outcomes:
Locations:
city: Bursa
country: Turkey
facility: Uludağ University Hospital Physical Medicine and Rehabilitation Clinic
state: Nilüfer
Study officials:
References: