Clinical trial NCT04277611: Comaprison Between QLB and ESPB in Patients for PCNL Operation
Official title: Comparison Between Ultrasound Guided Subcostal Oblique Quadratus Lumborum Block and Erector Spinae Plane Block in Patients Undergoing Percutaneous Nephrolithotomy
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Pain, Postoperative
Keywords: pain management
Nephrolithotomy
QLB
ESPB
Erector Spinae
Quadratus Lumborum
Anesthesia
ultrasound
regional anethesia
Lead sponsor: Assiut University
Sponsor class: OTHER
First posted: 2020-02-20
Enrollment: 92
Sex: ALL
Minimum age (years): 18
Maximum age (years): 60
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: SUPPORTIVE_CARE

Brief summary: comparing the subcostal oblique Quadratus Lumborum block and the Erector Spinae plane block in patients undergoing percutaneous nephrolithotomy operation to get the best and longest postoperative analgesic effect.

Detailed description: Here the investigators are going to compare between the Anterior approach for the subcostal oblique Quadratus Lumborum block (QLB) and the Erector Spinae Plane Block (ESPB) to determine their level of spread and their value in controlling postoperative pain in patients scheduled for Percutaneous Nephrolithotomy surgery. We hypothesized that quadratus lumborum is not inferior regarding the duration of analgesia when compared to erector spinae in patients undergoing percutaneous nephrolithotomy under general anesthesia.

Eligibility criteria: Inclusion Criteria:

* Both sex
* Age: 18-60
* ASA (American Society of Anesthesiologists) class I and II
* Elective surgery
* Patients undergoing PNL surgery

Exclusion Criteria:

* Patient's refusal
* Allergy or contraindications to drugs used in the study
* Emergency surgery
* Psychiatric disorders
* Severely co-morbid patients
* Inflammation or infection over injection site
* Bleeding diathesis; INR more than 1.5 and Platelet count less than 100,000/mm3
* Peripheral neuropathy
* Obese patients BMI ≥35
* Patients on previous opioid therapy
* Pre-operative haemoglobin \<10 mg/dl
* Inability to properly describe postoperative pain to investigators
* Coagulation abnormalities
* History of drug addiction or alcohol abuse
* History of Previous renal surgery

Primary outcomes:
measure: Analgesia
timeFrame: 48 hours
Secondary outcomes:
measure: Analgesia
timeFrame: 24 hours
measure: episodes of nausea and vomiting
timeFrame: within 24 hours postoperative
measure: Pain Scores using Visual Analog Scale (VAS) Scores
timeFrame: 24 hours postoperative.
measure: ambulation time
timeFrame: 5 days postoperative
measure: time of recovery of bowl movement
timeFrame: 5 days postoperative
measure: patient satisfaction with anesthesia
timeFrame: 48 hours postoperative.
measure: postoperative length of hospital stay
timeFrame: within 2 weeks postoperative.
Other outcomes:
Locations:
city: Assiut
country: Egypt
facility: Assiut University Hospitals
Study officials:
affiliation: Assiut University
name: Amr Thabet, Lecturer
role: STUDY_DIRECTOR
affiliation: Assiut University
name: Alaa Attia, Professor
role: STUDY_CHAIR
References: