Clinical trial NCT01224561: Adaptation of Lipid and Energy Metabolism During a Lipid Overnutrition in Constitutional Thinness
Official title: Adaptation of Lipid and Energy Metabolism During a Lipid Overnutrition in Constitutional Thinness
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Lipid Overnutrition
Constitutional Thinness
Keywords: Thinness
Leanness
healthy volunteers
Lipid metabolism disorder
Lead sponsor: Centre Hospitalier Universitaire de Saint Etienne
Sponsor class: OTHER
Collaborators: name: Ministry of Health, France
First posted: 2010-10-20
Enrollment: 26
Sex: FEMALE
Minimum age (years): 18
Maximum age (years): 35
Standard ages: ADULT
Accepts healthy volunteers: yes
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Constitutionnal thinness women and healthy volonteers(women)

Brief summary: For a given food intake, fat and energy metabolism in adipose tissue and muscle adapt to nutrient intakes. This adaptation to nutrition may be impaired in susceptible individuals or in obese patients by promoting weight gain, either in constitutional thinness (MC) by blocking it. The MC is a little known entity. These patients wish to grow for her and others. Can they? We have demonstrated abnormalities of hormones regulating appetite (ghrelin, PYY, GLP1 and leptin) that may participate in thinness. Furthermore, this thinness is associated with osteoporosis in 25% of true MC who is 25 years old.

Detailed description: This project aims to overfed MCs and follow the control parameters of energy metabolism. We will look for abnormalities in the adaptation to overnutrition in subjects with genetic background of thinness, which could explain the resistance to weight gain. The answer could possibly help to understand obesity.

Eligibility criteria: Inclusion Criteria:

* consent form the study signed
* consent form for genetic study signed
* normal laboratory values for liver enzymes, glucose, lipid

Exclusion Criteria (common to the two groups):

* pregnant
* vegetarian
* heavy smoking
* heavy alcohol
* depressive
* taking hypolipidemic or antihypertensive drugs
* dyslipidemia

Primary outcomes:
measure: gene expression
timeFrame: After one month of lipid overnutrition
Secondary outcomes:
measure: Anthropometric parameter
timeFrame: After one month of lipid overnutrition
measure: Autonomic nervous system activity
timeFrame: After one month of lipid overnutrition
measure: gastrointestinal hormone level
timeFrame: After one month of lipid overnutrition
measure: Anthropometric parameter
timeFrame: After one month of lipid overnutrition
measure: Anthropometric parameter
timeFrame: After one month of lipid overnutrition
measure: gastrointestinal hormone level
timeFrame: After one month of lipid overnutrition
measure: gastrointestinal hormone level
timeFrame: After one month of lipid overnutrition
Other outcomes:
Locations:
city: Clermont-Ferrand
country: France
facility: CRNH Auvergne
city: Lyon
country: France
facility: CRNH Rhône-Alpes
city: Saint-etienne
country: France
facility: CHU de Saint-Etienne
Study officials:
affiliation: CHU de Saint-Etienne
name: Bruno ESTOUR, MD PhD
role: PRINCIPAL_INVESTIGATOR
References: