Clinical trial NCT06333470: Liwan Eye Study: the Fourth Follow-up
Official title: Liwan Eye Study: the Fourth Follow-up
Study type: OBSERVATIONAL
Overall status: NOT_YET_RECRUITING
Conditions: Primary Angle-Closure Glaucoma
Lead sponsor: Zhongshan Ophthalmic Center, Sun Yat-sen University
Sponsor class: OTHER
First posted: 2024-03-27
Enrollment: 600
Sex: ALL
Minimum age (years): 70
Maximum age (years): 100
Standard ages: OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: CROSS_SECTIONAL
Sampling method: PROBABILITY_SAMPLE
Study population: All participants who will be follow-up in this study are from the Liwan Eye Study. At baseline, study subjects were enrolled in Liwan District, Guangzhou. (Liwan District is 1 of 10 administrative districts in Guangzhou, with a population of 514,600.) The decision to select this district for the survey was taken because of its stable, older population and a socioeconomic profile representative of Guangzhou as a whole. Individuals aged 50 years or more who had been resident in the selected study districts for more than 6 months were considered eligible during the enumeration. A total of 1405 eligible subjects were identified from the register.

Brief summary: Primary angle-closure glaucoma (PACG) is one of the major causes of blindness affecting more than 20 million patients worldwide. The goals of this observational cohort study are to investigate the 20-year incidence of PACG in Chinese population aged 50 years and to develop prediction models for the long-term risk of progression from primary angle-closure suspect (PACS) to PACG.

Detailed description: Primary angle-closure glaucoma (PACG) is potentially a devastating disease, responsible for half of glaucoma-related blindness worldwide, especially in East Asia. Primary angle-closure suspect (PACS), which is characterized by appositional angle closure, is the earliest stage of primary angle closure diseases and can finally progress to PACG. Thus, identifying PACS eyes at risk of angle closure is crucial for its management. However, the natural history of progression from PACS to PACG and its prediction models are still limited in long-term longitudinal studies. Meanwhile, visual impairment poses a significant global public health burden along with the accelerating trend of aging, it is imperative to further evaluate the visual impairment among the elderly population.

The Liwan Eye Study was a population-based study initiated in 2003. The decision to select Liwan District for the survey was taken because of its stable, older population and a socioeconomic profile representative of Guangzhou as a whole. At baseline, 1405 eligible subjects aged 50 years and older completed a comprehensive eye examination and a questionnaire interview regarding education, income, hypertension and diabetes mellitus. To improve the monitoring of PACS and prevent vision loss associated with PACG, the purposes of this observational cohort study are to investigate the 20-year incidence of PACG in Chinese population aged over 50 years, develop prediction models that include eye characteristics, demographic features, ocular imaging characteristics, and genetic factors for the long-term risk of progression from PACS to PACG. Moreover, we aim to investigate the 20-year change in visual impairment and associated factors.

Eligibility criteria: Inclusion Criteria:

* Participants who have previously participated in the Liwan Eye Study
* Individuals who sign an informed consent form voluntarily

Exclusion Criteria:

* None

Primary outcomes:
measure: The 20-year incidence of primary angle-closure glaucoma (PACG) in Chinese population aged over 50 years
timeFrame: 20-year
Secondary outcomes:
measure: The development of prediction models for the long-term risk of progression from primary angle-closure suspect (PACS) to primary angle-closure glaucoma (PACG)
timeFrame: 5-year, 10-year, 20-year
measure: The 20-year incidence of visual impairment in Chinese population aged over 50 years
timeFrame: 20-year
Other outcomes:
Locations:
Study officials:
affiliation: Zhongshan Ophthalmic Center, Sun Yat-sen University
name: Wei Wang, PhD
role: PRINCIPAL_INVESTIGATOR
References: