Clinical trial NCT03355729: The Quebec Family Study (QFS): Role of Genetic Factors in Obesity and Its Related Risk Factors and Diseases
Official title: The Quebec Family Study: an Observational Study Aimed at Investigating the Role of Genetic Factors in Physical Fitness, Obesity and Risk Factors for Common Diseases and Health-related Behaviours
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Obesity
Physical Fitness
Lead sponsor: Laval University
Sponsor class: OTHER
Collaborators: name: Canadian Institutes of Health Research (CIHR)
First posted: 2017-11-28
Enrollment: 951
Sex: ALL
Minimum age (years): 10
Standard ages: CHILD
ADULT
OLDER_ADULT
Observational model: FAMILY_BASED
Time perspective: CROSS_SECTIONAL
Sampling method: NON_PROBABILITY_SAMPLE
Study population: The QFS cohort is a mixture of random sampling and ascertainment through obese individuals. In Phase 1 of the study, subjects were randomly selected from French-Canadian families living in the Quebec city area, In Phases 2 and 3 of the study, families with a least one obese parent and one obese offspring were recruited.

Brief summary: The Quebec Family Study (QFS) is an observational study that was planned to investigate the role of genetic factors in physical fitness, body composition, risk factors for common disease and health-related behaviour.

Detailed description: The Quebec Family Study was an observational study with three cycles of data collection between 1978 and 1992. During the first cycle of data collection (Phase 1: 1978-1982), a total of 1,650 subjects from 375 families were recruited. During the second cycle (Phase 2: 1989-1997), 385 subjects from 105 phase 1 families were retested and an additional 372 subject from 74 families were recruited. During the third cycle (Phase 3: 1998-2002), 204 subjects from phase 1 were tested a third time, 113 subjects from phase 2 were tested a second time and 194 new subjects from 44 families were recruited.

Eligibility criteria: Inclusion Criteria:

* Age over 10 years

Exclusion Criteria:

* Not applicable

Primary outcomes:
measure: Body composition
timeFrame: Through study completion, an average of 24 years
measure: Body mass index (kg/m^2)
timeFrame: Through study completion, an average of 24 years
measure: Abdominal fat
timeFrame: Through study completion, an average of 24 years
measure: Waist and hip circumferences (cm)
timeFrame: Through study completion, an average of 24 years
Secondary outcomes:
measure: Caloric intake
timeFrame: Through study completion, an average of 24 years
measure: Eating behaviour
timeFrame: Through study completion, an average of 24 years
measure: Energy expenditure
timeFrame: Through study completion, an average of 24 years
measure: Physical activity level
timeFrame: Through study completion, an average of 24 years
measure: Blood pressure (mm Hg)
timeFrame: Through study completion, an average of 24 years
measure: Plasma lipid levels (mmol/L)
timeFrame: Through study completion, an average of 24 years
measure: Glucose levels (mmol/L)
timeFrame: Through study completion, an average of 24 years
measure: Insulin levels (pmol/L)
timeFrame: Through study completion, an average of 24 years
measure: C-reactive protein (CRP in mg/ml)
timeFrame: Through study completion, an average of 24 years
measure: Adiponectin levels (in micrograms/ml)
timeFrame: Through study completion, an average of 24 years
measure: Interleukin-6 (IL6) and tumor necrosis factor-alpha (TNF-alpha) in pg/ml
timeFrame: Through study completion, an average of 24 years
measure: Smoking habits (nb of cigarettes per day)
timeFrame: Through study completion, an average of 24 years
measure: Sleeping (hours/day)
timeFrame: Through study completion, an average of 24 years
measure: Alcohol consumption
timeFrame: Through study completion, an average of 24 years
Other outcomes:
Locations:
Study officials:
affiliation: Pennington Biomedical Center
name: Claude Bouchard, Ph.D.
role: PRINCIPAL_INVESTIGATOR
affiliation: Laval University
name: Louis Perusse, Ph.D.
role: STUDY_DIRECTOR
References:
citation: Chaput JP, Perusse L, Despres JP, Tremblay A, Bouchard C. Findings from the Quebec Family Study on the Etiology of Obesity: Genetics and Environmental Highlights. Curr Obes Rep. 2014 Jan 4;3(1):54-66. doi: 10.1007/s13679-013-0086-3. eCollection 2014.
citation: Jacob R, Drapeau V, Tremblay A, Provencher V, Bouchard C, Perusse L. The role of eating behavior traits in mediating genetic susceptibility to obesity. Am J Clin Nutr. 2018 Sep 1;108(3):445-452. doi: 10.1093/ajcn/nqy130.