louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT06659185: Carbohydrate Mouth Rinsing and Softball Batting Performance
Official title: Carbohydrate Mouth Rinsing and Softball Batting Performance: a Double-blind Crossover Study
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Carbohydrate
Keywords: batting accuracy
performance
Lead sponsor: National Taiwan Sport University
Sponsor class: OTHER
First posted: 2024-10-26
Enrollment: 14
Sex: FEMALE
Minimum age (years): 20
Maximum age (years): 30
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: CROSSOVER
Intervention model description: a double-blind crossover study
Primary purpose: TREATMENT

Brief summary: Participants rinsed their mouths for 20 seconds with 25 ml of either 6.4% maltodextrin (CMR) or placebo (PLA). After rinsing, the grip force, counter-movement jump (CMJ) and batting tests were performed in sequence.

Detailed description: The purpose of this study was to investigate the effect of CMR on softball batting performance. Fourteen trained collegiate female softball players completed two trials in a randomization crossover trail, in which they rinsed their mouths for 20 seconds with 25 ml of either 6.4% maltodextrin (CMR) or placebo (PLA). After rinsing, the grip force, counter-movement jump (CMJ) and batting tests were performed in sequence. The tanner tee was utilised to perform five sets of five balls at a time, with a minimum of 3 minutes rest between sets. The batting test recorded average exit velocity, maximum exit velocity and batting accuracy. The standardized standard deviation (SD) for launch angle represents standardized variability.

Eligibility criteria: Inclusion Criteria:

* more than 6 years of professional fast-pitch softball training
* more than 6 months of continuous training
* from at least the top four teams in the country

Exclusion Criteria:

* non-professionally fast-pitch softball training
* lack of regular training in the past 6 months
* in the event that the applicant has sustained a sports injury or is currently experiencing epilepsy, hypertension, hyperlipidemia, heart disease, arthritis, osteoporosis, or a brain injury, and has yet to undergo a period of recuperation exceeding three months

Primary outcomes:
measure: exit velocity
timeFrame: 20 seconds after rinsing
Secondary outcomes:
measure: batting accuracy
timeFrame: 20 seconds after rinsing
Other outcomes:
Locations:
city: Taichung
country: Taiwan
facility: National Taiwan University of Sport
state: North
Study officials:
affiliation: National Taiwan University of Sport
name: Chih Hui Chiu, PhD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT04874285: Use of Dietary Supplements in Patients at Risk of Abortion Treated With Progesterone.
Official title: Supplementation With Hyaluronic Acid, Alpha-lipoic Acid, Magnesium, and Vitamin D and B6 in Patients at Risk of Abortion Treated With Progesterone: a Pilot Study.
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Pregnancy, High Risk
Lead sponsor: Lo.Li.Pharma s.r.l
Sponsor class: INDUSTRY
First posted: 2021-05-05
Enrollment: 63
Sex: FEMALE
Minimum age (years): 18
Maximum age (years): 50
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: PREVENTION

Brief summary: The trial aims to investigate the effect of supplementation with hyaluronic acid, alpha-lipoic acid, magnesium, vitamin D and vitamin B6 in progesterone-treated pregnant women with risk factors for abortion.


Eligibility criteria: Inclusion Criteria:

* Women with risk factor for abortion (sub-chorionic hematoma during gestation or ART procedures)

Exclusion Criteria:

* Other pregnancy-related conditions
* Diabetes or hypertension
* Concomitant pharmacological therapies (anticoagulant or antihypertensive)
* Use of tocolytic drugs two months prior to enrollment
* Association with hypoglycemic drugs

Primary outcomes:
measure: reduction of the abortion rate
timeFrame: 1 day (single time-point before week 20 of gestation)
Secondary outcomes:
Other outcomes:
Locations:
city: Rome
country: Italy
facility: Clinica Alma Res
Study officials:
References:
Clinical trial NCT02491385: Thoracic Epidural for Postoperative Ileus
Official title: Effect of Thoracic Epidural Analgesia on Bowel Function Recovery in Major Upper Abdominal Surgeries
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Ileus
Keywords: Thoracic epidural analgesia
bowel function recovery
Lead sponsor: Samsung Medical Center
Sponsor class: OTHER
First posted: 2015-07-08
Enrollment: 28
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NON_RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The investigators try to find whether thoracic epidural analgesia (TEA) shortens the first gas-out time compared to iv-PCA and promotes earlier discharge after major upper abdominal surgery.

Detailed description: Postoperative ileus (POI) is a prolonged inhibition of coordinated bowel activity after surgery. Half of patients undergoing major abdominal surgery experience POI making it one of the limiting factors for early recovery.

The pathogenesis of POI is multifactorial, and includes neurogenic, inflammatory and pharmacological mechanisms. Thoracic epidural analgesia (TEA) can induce sympathetic block, attenuate inflammatory reaction and limit use of systemic opioids. In addition, sympatholysis induced by TEA can improve microcirculation of bowels and parasympathetic activation can increase gastrointestinal motility.

However, studies comparing TEA and iv-PCA on POI are rare in major upper abdominal surgeries. This study, therefore, compares TEA and iv-PCA in terms of bowel function recovery as a primary endpoint in major upper abdominal surgeries. Secondary endpoints are side effects and hospital stay.

Eligibility criteria: Inclusion Criteria:

* American Society of Anesthesiologists' (ASA) physical statusⅠ-Ⅲ

Exclusion Criteria:

* ASA status of Ⅳ, or more
* Body mass index 30 kg.m2-1 or more
* Severe renal, hepatic, or neurologic diseases
* Opioid or systemic analgesic preoperatively

Primary outcomes:
measure: gas out time
timeFrame: from operation to post operative 10 days
Secondary outcomes:
measure: voiding time
timeFrame: from operation to post operative 10 days
measure: numeric rating scale for pain
timeFrame: from operation to post operative 3 days
Other outcomes:
Locations:
city: Seoul
country: Korea, Republic of
facility: Samsung medical center
Study officials:
affiliation: Department of Anesthesiology and Pain Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine
name: Hyun Joo Ahn, Professor
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT02744885: Crave Crush Behavioral Study
Official title: Crave Crush: Sugar Cravings and ad Lib Candy Uptake
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Obesity
Lead sponsor: Oregon Research Behavioral Intervention Strategies, Inc.
Sponsor class: INDUSTRY
Collaborators: name: Cravecrush
name: Oregon Behavioral Intervention Strategies, Inc.
First posted: 2016-04-20
Enrollment: 67
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: BASIC_SCIENCE

Brief summary: The purpose of the research is to determine if participants who take "Crave Crush" will report lower cravings and palatability ratings of candy as compared to subjects who receive the placebo. Participants are self-selected university students who pass our table and verbally agree to participate in a research study about taste preferences. Data will be recorded anonymously.

Detailed description: When students approach the table, research assistants will ask them to choose their favorite kind of candy from an assortment. They will ask the subjects to rate their craving for the candy before they taste it. After they try the candy, the research assistants will ask them to rate its palatability. Then they will rate their craving for another piece of candy. A research assistant will flip a coin to determine whether the subject will receive Crave Crush or placebo. While the Crave Crush or placebo is dissolving in the mouth, the students will fill out a short questionnaire with an identification number. The questionnaire will ask for their age, gender, ethnicity, approximate height and weight, and a few questions about their dietary habits.

After the tablet dissolves, research assistants will ask the students to rate their craving for another piece of candy. Research assistants will ask participants if they would like another piece of candy and have them assess palatability again. The process of offering a piece of candy and asking subjects to rate palatability will occur up to five times. Finally, subjects will be asked if they would like to take a few pieces of candy for the road and if they say yes, the number of pieces they take with them will be noted. The study activities should last no more than 5-10 minutes per participant.

Eligibility criteria: Inclusion Criteria:

* University student, having eaten within the last hour, having slept within two hours of their normal amount

Exclusion Criteria:

-

Primary outcomes:
measure: Self-Reported Craving Reduction
timeFrame: 10 minutes
Secondary outcomes:
measure: Self-Reported Palatability Reduction
timeFrame: 10 minutes
Other outcomes:
Locations:
Study officials:
References:
citation: Stice E, Yokum S, Gau JM. Gymnemic acids lozenge reduces short-term consumption of high-sugar food: A placebo controlled experiment. J Psychopharmacol. 2017 Nov;31(11):1496-1502. doi: 10.1177/0269881117728541. Epub 2017 Sep 25.
Clinical trial NCT02718885: Gut Microbiome Mediated Effects of Inulin Supplementation on Mineral and Bone Metabolism in Hemodialysis Patients
Official title: Gut Microbiome Mediated Effects of Inulin Supplementation on Mineral and Bone Metabolism in Hemodialysis Patients
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: EARLY_PHASE1
Conditions: Bone Diseases, Endocrine
Nutritional and Metabolic Diseases
Keywords: inulin-type fructans
hemodialysis
gut microbiome
mineral and bone disorder
Lead sponsor: University of Illinois at Urbana-Champaign
Sponsor class: OTHER
Collaborators: name: Renal Research Institute
First posted: 2016-03-24
Enrollment: 20
Sex: ALL
Minimum age (years): 20
Maximum age (years): 65
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: CROSSOVER
Primary purpose: SUPPORTIVE_CARE

Brief summary: The overall objective of the study is to examine the changes within the gut microbiome after the supplementation of inulin and its effect on markers of mineral metabolism and bone turnover.

Detailed description: In this randomized controlled cross-over study, twenty HD patients (10 male/10 female, aged 20-80) will be recruited from local dialysis clinics in Champaign-Urbana, IL. After baseline testing, patients will be randomized to the intervention group or placebo group (maltodextrin). Patients will consume inulin (females 10g/day, males 15g/day) or maltodextrin (females 10g/day, males 15g/day) for one month, rest for two weeks (washout period), and continue with the other treatment (either inulin or maltodextrin) for another month. Outcomes will be assessed at the beginning of each period and after a month of supplementation at both periods.

Eligibility criteria: Inclusion Criteria:

* Receive HD therapy 3 days per week and for at least 3 months

Exclusion Criteria:

* Sustained hypercalcemia (\>3months).
* Previous major gastrointestinal disease diagnosis (e.g., inflammatory bowel disease and celiac disease).
* Antibiotic treatment \< 2 weeks prior the start of the study.

Primary outcomes:
measure: Mineral metabolism
timeFrame: 4 weeks
Secondary outcomes:
measure: Bone biomarkers
timeFrame: 4 weeks
measure: Gut-microbiota derived metabolites
timeFrame: 4 weeks
measure: Gut microbiome
timeFrame: 4 weeks
Other outcomes:
Locations:
city: Urbana
country: United States
facility: University of Illinois at Urbana-Champaign
state: Illinois
Study officials:
affiliation: University of Illinois at Urbana-Champaign
name: Kenneth Wilund, Ph.D.
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT05860985: Zeiss RESIGHT Disposable Lenses Evaluation Study
Official title: Zeiss RESIGHT Disposable Lenses Evaluation Study: Investigator-initiated, Mono-center, Academic, Prospective, Interventional Case Study
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Retinal Detachment
Macular Pucker
Macular Holes
Vitreomacular Traction
Lead sponsor: Universitaire Ziekenhuizen KU Leuven
Sponsor class: OTHER
First posted: 2023-05-16
Enrollment: 120
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: NON_RANDOMIZED
Intervention model: PARALLEL
Primary purpose: OTHER

Brief summary: To evaluate the intra-operative efficacy of a new intra-operative viewing device.

Detailed description: This study is designed to obtain more information on the efficacy of the disposable RESIGHT lenses in routine vitrectomy surgery. This information can lead to adjustments to these surgical lenses to further fine tune a device which can be used by other surgeons.

Theoretically, both the improved lens design and better resistance to fogging should improve the visualization of the retina hence facilitate the surgery, increasing the surgical safety.

Eligibility criteria: Inclusion Criteria:

* Voluntary written informed consent of the participant or their legally authorized representative has been obtained prior to any screening procedures
* Patients that are scheduled for primary vitrectomy surgery to treat retinal detachment or macular disease (pucker, macular hole, vitreomacular traction).
* Both vitrectomy-only and combined phaco-vitrectomy surgeries
* General or local anesthesia, or combination

Exclusion Criteria:

* Patient who do not have sufficient command of the Dutch language to read and understand the informed consent form
* Any disorder, which in the investigator's opinion might jeopardise participant's safety or compliance with the CIP.
* Repeat vitrectomy surgery

Primary outcomes:
measure: Ultra Wide Field lens View Angle evaluation
timeFrame: during surgery
measure: Ultra Wide Field lens Condensation evaluation
timeFrame: during surgery
measure: Wide Angle lens Condensation evaluation
timeFrame: during surgery
measure: Illumination appearance evaluation
timeFrame: during surgery
measure: Color appearance evaluation
timeFrame: during surgery
Secondary outcomes:
Other outcomes:
Locations:
city: Leuven
country: Belgium
facility: Universitaire Ziekenhuizen Leuven
state: Vlaams-Brabant
Study officials:
affiliation: UZ Leuven
name: Peter Stalmans, PhD, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT03165656: Right Ventricular Function at Rest in Highlanders/Lowlanders
Official title: Right Ventricular Function at Rest in Highlanders With Pulmonary Hypertension Compared to Highlanders Without Pulmonary Hypertension and Lowlanders
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: High Altitude Pulmonary Hypertension
Keywords: Echocardiography
right ventricular function
pulmonary hypertension
disease progression
hypoxia
Lead sponsor: University of Zurich
Sponsor class: OTHER
Collaborators: name: National Center of Cardiology and Internal Medicine named after academician M.Mirrakhimov
First posted: 2017-05-24
Enrollment: 173
Sex: ALL
Minimum age (years): 16
Standard ages: CHILD
ADULT
OLDER_ADULT
Observational model: CASE_CONTROL
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Highlanders with high altitude pulmonary hypertension living at an altitude of 2500-4000 m; healthy highlanders living at an altitude of 2500-4000 m; healthy lowlanders living at an altitude of \<1000 m.

Brief summary: The purpose of the current study is to evaluate the progression of right ventricular function and dimension in Kyrgyz highlanders with high altitude pulmonary hypertension (HAPH) by performing a cross sectional case-control study.


Eligibility criteria: Inclusion Criteria:

* high altitude pulmonary hypertension confirmed by clinical presentation and mean pulmonary artery pressure \>30 mmHg measured by echocardiography at altitude of residence.
* healthy subjects (high altitude controls)
* Both genders
* Age \>16 y
* Kyrgyz ethnicity
* born, raised and currently living at \>2500 m
* healthy subjects currently living at \<1000 m (low altitude controls)

Exclusion Criteria:

* Pulmonary hypertension from other causes, in particular from left ventricular failure as judged clinically and by echocardiography
* Excessive erythrocytosis
* Other coexistent disorders that may interfere with the cardio-respiratory system and sleep
* Regular use of medication that affects control of breathing
* Heavy smoking

Primary outcomes:
measure: Pulmonary artery pressure
timeFrame: Day 2
Secondary outcomes:
measure: cardiac output
timeFrame: Day 2
measure: right heart dimensions
timeFrame: Day 2
measure: Right heart function
timeFrame: Day 2
measure: stroke volume
timeFrame: Day 2
measure: volumes
timeFrame: Day 2
Other outcomes:
Locations:
city: Bishkek
country: Kyrgyzstan
facility: National Center for Cardiology and Internal Medicine
Study officials:
affiliation: National Center of Cardiology and Internal Medicine, Bishkek, Kyrgyzstan
name: Talant M Sooronbaev, MD
role: STUDY_CHAIR
References:
citation: Gosens R, Hiemstra PS, Adcock IM, Bracke KR, Dickson RP, Hansbro PM, Krauss-Etschmann S, Smits HH, Stassen FRM, Bartel S. Host-microbe cross-talk in the lung microenvironment: implications for understanding and treating chronic lung disease. Eur Respir J. 2020 Aug 20;56(2):1902320. doi: 10.1183/13993003.02320-2019. Print 2020 Aug.
Clinical trial NCT03911856: Unmasking Right Ventricular and Pulmonary Derangements With Exercise and Oxygen in Early Stage Cardiopulmonary Diseases
Official title: Unmasking Right Ventricular and Pulmonary Derangements With Exercise and Oxygen in Early Stage Cardiopulmonary Diseases
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Cardiopulmonary Disease
Lead sponsor: Mayo Clinic
Sponsor class: OTHER
First posted: 2019-04-11
Enrollment: 7
Sex: ALL
Minimum age (years): 18
Maximum age (years): 80
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: NON_RANDOMIZED
Intervention model: PARALLEL
Primary purpose: OTHER

Brief summary: Researchers are trying to develop innovative strategies that target the early identification heart and lung imbalances in patients with cardiopulmonary diseases.


Eligibility criteria: Inclusion criteria:

* Healthy controls (no known cardiac or pulmonary disease);
* PAH/HFpEF patients with known RV failure;
* PAH/HFpEF patients with known pulmonary failure
* Newly diagnosed PAH/HFpEF patients without any evidence of profound RV or pulmonary dysfunction.

Exclusion criteria:

* Persons unable to perform light exercise
* Persons pregnant or planning to be pregnant

Primary outcomes:
measure: Change in stroke volume (SV) during exercise and hyperoxia
timeFrame: 2 years
measure: Change in oxygen uptake (VO2) during exercise and hyperoxia
timeFrame: 2 years
measure: Change in ventilatory efficiency (VE/VCO2) during exercise and hyperoxia
timeFrame: 2 years
Secondary outcomes:
Other outcomes:
Locations:
city: Rochester
country: United States
facility: Mayo Clinic in Rochester
state: Minnesota
Study officials:
affiliation: Mayo Clinic
name: Bruce D Johnson
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT05670756: Preoperative Survey to Evaluate Patient Allergy
Official title: Preoperative Survey to Evaluate Patient Allergy List, Type of Response to Listed Medication, and Its Relevance to Perioperative Care
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Allergy Drug
Allergic Reaction
Pediatric
Surgery
Lead sponsor: Nationwide Children's Hospital
Sponsor class: OTHER
First posted: 2023-01-04
Enrollment: 250
Sex: ALL
Maximum age (years): 21
Standard ages: CHILD
ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Patients presenting for surgery at a children's hospital.

Brief summary: The study will only involve identification of the listed allergies from the electronic medical record and investigation into the symptoms that prompted this allergy listing. The purpose is to evaluate demographics and prevalence of allergies in patients presenting for surgery, evaluate the medical decision making process behind allergy identification, and determine its potential impact on perioperative care. The participants will be asked to complete a survey in REDCap using an iPad during the visit.


Eligibility criteria: Inclusion Criteria:

* Patients 0-21 years of age presenting for surgery or procedure requiring anesthesia

Exclusion Criteria:

* Patients who are not able cognitively to complete the computerized survey due to physical or intellectual impairment or communication issues related to non-English speaking patients

Primary outcomes:
measure: True Allergy (Consistent With an IgE-mediated Reaction)
timeFrame: Baseline
Secondary outcomes:
measure: Unlikely True Allergy (Less Relevant With an IgE-mediated Reaction)
timeFrame: Baseline
measure: Not True Allergy (Not Related to IgE-mediated Reaction)
timeFrame: Baseline
Other outcomes:
Locations:
city: Columbus
country: United States
facility: Nationwide Children's Hospital
state: Ohio
Study officials:
References:
Clinical trial NCT06913556: Comparing Effect of Hylorunic Acid and Lipid-coated Carbomer Gel on Dry Eyes After Phacoemulsification in DP
Official title: Comparing Effect of Hylorunic Acid and Lipid-coated Carbomer Gel on Dry Eyes After Phacoemulsification in Diabetic Patients
Study type: INTERVENTIONAL
Overall status: ACTIVE_NOT_RECRUITING
Phase: NA
Conditions: Dry Eye Syndrome
Lead sponsor: Superior University
Sponsor class: OTHER
First posted: 2025-04-06
Enrollment: 64
Sex: ALL
Minimum age (years): 50
Maximum age (years): 70
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: HEALTH_SERVICES_RESEARCH

Brief summary: In this research checked the curative effect of two different artificial tears on dry eyes after phacoemulsification was checked. In research, the randomized control trial methodology is used


Eligibility criteria: Inclusion Criteria:

* Patients aged 50-70
* Both gender male /female

Exclusion Criteria:

* Patients who have acute dry eye condition before phacoemulsification cataract surgery.

Primary outcomes:
measure: The Tear Break-Up Time (TBUT) test
timeFrame: 12 Months
measure: Schirmer test
timeFrame: 12 Months
Secondary outcomes:
Other outcomes:
Locations:
city: Lahore
country: Pakistan
facility: Shaheen welfare hospital
state: Punjab
Study officials:
References: