Clinical trial NCT06870656: Muscle Isometric Contraction for the Treatment of Knee Osteoarthritis
Official title: Muscle Isometric Contraction for the Treatment of Knee Osteoarthritis
Study type: INTERVENTIONAL
Overall status: NOT_YET_RECRUITING
Phase: NA
Conditions: Knee Osteoarthritis (Knee OA)
Keywords: KOA
Muscle isometric contraction
Lead sponsor: Chengdu Sport University
Sponsor class: OTHER
First posted: 2025-03-11
Enrollment: 120
Sex: FEMALE
Minimum age (years): 60
Maximum age (years): 80
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: PREVENTION

Brief summary: This study compares the effects of three different intensities of Muscle Isometric Contraction (MIC) on balance ability, proprioception, muscle strength, KOA symptoms, and inflammatory factors in synovial fluid among elderly individuals with Knee Osteoarthritis (KOA).

Detailed description: A total of 120 elderly individuals with Knee Osteoarthritis (KOA) will be recruited and randomly assigned into four groups using a digital randomization method: low-intensity group (n = 30), medium-intensity group (n = 30), high-intensity group (n = 30), and control group (n = 30). The elderly individuals in the low-, medium-, and high-intensity groups will receive five interventions per week targeting the quadriceps femoris muscle. For each intervention, the quadriceps will perform an isometric contraction and relaxation for 1 second each. The low-, medium-, and high-intensity groups will perform 10, 20, and 30 repetitions per set, respectively, of Muscle Isometric Contraction (MIC) (guided by a rhythmic timer), completing a total of 10 sets with a 30-second rest between sets. The entire intervention will last for 16 weeks. Researchers will follow up with participants weekly to complete exercise record forms, ensuring that all subjects maintain their original lifestyle and dietary habits. The study aims to compare the effects of three different intensities of MIC on balance ability, proprioception, muscle strength, KOA symptoms, and inflammatory factors in synovial fluid among elderly individuals with KOA.

Eligibility criteria: Inclusion Criteria:

* Women aged 60 to 80 years;
* Based on the diagnostic criteria for knee osteoarthritis (KOA) established by the American College of Rheumatology in 2001, participants with KOA graded 1 to 3 were selected;
* Compliance with the Declaration of Helsinki and signing of the informed consent form.

Exclusion Criteria:

* Cardiovascular diseases;
* Need for surgery or pharmacological treatment in the near future;
* Neuromuscular diseases;
* Currently engaged in regular exercise.

Primary outcomes:
measure: KOA Symptoms
timeFrame: 16 weeks
measure: Balance Ability
timeFrame: 16 weeks
measure: Muscle Strength
timeFrame: 16 weeks
measure: Proprioception
timeFrame: 16 weeks
measure: Expression of IL-1β in Knee Synovial Fluid
timeFrame: 16 weeks
measure: Expression of TNF-α in Knee Synovial Fluid
timeFrame: 16 weeks
measure: Expression of MMP-13 in Knee Synovial Fluid
timeFrame: 16 weeks
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
affiliation: Chengdu Sport University
name: Liang Cheng
role: PRINCIPAL_INVESTIGATOR
References: