Clinical trial NCT00002550: Chemotherapy Plus Radiation Therapy With or Without Surgery in Treating Patients With Stage IIIA Non-small Cell Lung Cancer
Official title: A Phase III Comparison Between Concurrent Chemotherapy Plus Radiotherapy and Concurrent Chemotherapy Plus Radiotherapy Followed by Surgical Resection for Stage IIIA (N2) Non-Small Cell Lung Cancer
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE3
Conditions: Lung Cancer
Keywords: squamous cell lung cancer
large cell lung cancer
stage IIIA non-small cell lung cancer
adenocarcinoma of the lung
bronchoalveolar cell lung cancer
Lead sponsor: Radiation Therapy Oncology Group
Sponsor class: NETWORK
Collaborators: name: National Cancer Institute (NCI)
name: SWOG Cancer Research Network
name: Eastern Cooperative Oncology Group
name: Cancer and Leukemia Group B
name: North Central Cancer Treatment Group
name: NCIC Clinical Trials Group
First posted: 2003-04-10
Enrollment: 429
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Combining radiation therapy with chemotherapy may kill more tumor cells. It is not yet known if chemotherapy plus radiation therapy is more effective with or without surgery for lung cancer.

PURPOSE: Randomized phase III trial to compare the effectiveness of combining cisplatin, etoposide, and radiation therapy with or without surgery in treating patients who have stage IIIA non-small cell lung cancer.

Detailed description: OBJECTIVES:

Primary

* Compare the progression-free survival, median (2-year) survival, and long-term (5-year) survival in patients with newly diagnosed, stage IIIA (N2) non-small cell lung cancer treated with radiotherapy concurrently with cisplatin and etoposide with or without surgical resection.

Secondary

* Compare the patterns of local and distant failure in patients treated with these regimens.
* Determine the relationship of tobacco use, alcohol use, and diet with toxicity of these regimens and outcome in both men and women.

OUTLINE: This is a randomized, multicenter study. Patients are stratified by contralateral mediastinal sampling or biopsy (yes vs no), tumor stage (T1 vs T2 vs T3), and performance status (70-80% vs 90-100%). Patients are randomized to 1 of 2 treatment arms.

* Arm I: Patients receive induction with cisplatin IV over 1 hour on days 1 and 8 and etoposide IV over 1 hour on days 1-5. Treatment continues every 4 weeks for 2 courses in the absence of disease progression or unacceptable toxicity. Beginning within 24 hours of the first dose of chemotherapy, patients undergo induction radiotherapy 5 days a week for 5 weeks in the absence of disease progression or unacceptable toxicity. Patients without local progression or distant metastases at 2-4 weeks after completion of course 2 undergo resection approximately 3-5 weeks after completion of course 2. All visible, accessible bronchopulmonary, hilar, and mediastinal lymph nodes are excised. The choice of surgical procedure (thoracotomy, lobectomy, or pneumonectomy with en bloc resection of tumor extending into the parietal pleura, chest wall, pericardium, or diaphragm) is at the discretion of the surgeon. Patients who undergo resection receive 2 additional courses of chemotherapy alone beginning 4-6 weeks postoperatively. Patients with unresectable disease or who are medically unfit for or refuse resection receive 2 additional courses of chemotherapy alone beginning immediately after completion of course 2.
* Arm II: Patients undergo induction chemoradiotherapy as in arm I but do not undergo resection. Patients without local progression or distant metastases within 1 week before anticipated completion of induction radiotherapy receive 2 additional courses of chemotherapy beginning immediately after completion of course 2. Patients without local or distant progression after completion of course 4 undergo boost radiotherapy for 8 days.

Patients are followed every 2 months for 1 year, every 3 months for 2 years, and then every 6 months thereafter.

PROJECTED ACCRUAL: A total of 510 patients will be accrued for this study within 4.9 years.

Eligibility criteria: DISEASE CHARACTERISTICS:

* Histologically or cytologically proven newly diagnosed, stage IIIA (T1-3, N2) non-small cell lung cancer

  * Eligible subtypes:

    * Adenocarcinoma
    * Large cell carcinoma
    * Squamous cell carcinoma
    * Nonlobar and nondiffuse bronchoalveolar cell carcinoma
* Measurable or evaluable disease on chest x-ray and/or contrast CT scan

  * Contrast thoracic CT required to complete staging
* Single primary bronchogenic tumor (no more than 1 parenchymal lung lesion)
* Pleural effusions allowed if 1 of the following conditions is met:

  * Negative cytology on thoracentesis if effusions present before mediastinoscopy or exploratory thoracotomy
  * Effusion seen on CT scan but not on chest x-ray and deemed too small to tap under CT or ultrasound guidance
* Positive ipsilateral mediastinal node(s) with or without positive ipsilateral hilar nodes

  * Mediastinal nodes separate from primary lesion on CT scan or surgical exploration
  * Histologic or cytologic proof of N2 disease by thoracotomy, mediastinoscopy, mediastinotomy, Chamberlain procedure, Wang needle, or fine needle aspiration under bronchoscopic or CT guidance
  * Nodal biopsy or aspiration waived if all of the following conditions are met:

    * Paralyzed left true vocal cord documented by bronchoscopy or indirect laryngoscopy
    * Nodes visible in Level 5 region on CT scan
    * Distinct primary lesion separate from nodes on CT scan
  * All mediastinal nodal involvement mapped (positive or negative)
* No positive nodes in contralateral mediastinum (supraclavicular areas and higher) and neck

  * Mediastinoscopy, mediastinotomy, Chamberlain procedure, or thoracotomy required for nodes larger than 1 cm on contrast CT scan
  * Surgery waived if nodes negative or no larger than 1 cm on CT scan
* Lymphadenopathy allowed if biopsy proof of a benign cause
* No metastases by contrast CT or MRI scan of the brain, bone scan, CT scan of the lungs to exclude other ipsilateral or contralateral parenchymal lesions, and contrast CT scan of the upper abdomen including entire liver and adrenals
* No hepatomegaly or splenomegaly by physical examination or CT scan unless documentation of a benign cause
* No pericardial effusion
* No superior vena cava syndrome
* No prior diagnosis of lung cancer

PATIENT CHARACTERISTICS:

Age:

* 18 and over

Performance status:

* Karnofsky 90-100% (70-80% allowed if albumin at least 0.85 times lower limit of normal and weight loss no greater than 10% within 3 months before diagnosis)

Hematopoietic:

* White blood cell count (WBC) at least 4,000/mm\^3 OR
* Granulocyte count at least 2,000/mm\^3
* Platelet count normal
* Hemoglobin at least 10.0 g/dL (less than 8.5 g/dL allowed if no marrow involvement with tumor)

Hepatic:

* See Performance status
* Bilirubin no greater than 1.5 times upper limit of normal (ULN)\*
* Serum glutamate oxaloacetate transaminase (SGOT) and serum glutamate pyruvate transaminase (SGPT) no greater than 1.5 times ULN\* NOTE: \* Unless documentation of a benign cause

Renal:

* Creatinine clearance at least 50 mL/min

Cardiovascular:

* No myocardial infarction within the past 3 months
* No active angina
* No unstable arrhythmia
* No congestive heart failure

Pulmonary:

* Forced expiratory volume at one second (FEV1) at least 2.0 liters OR
* Predicted postresection FEV1 at least 800 mL based on quantitative V/Q scan
* Diffusion capacity of lung for carbon monoxide (DLCO) at least 50% predicted (corrected for hemoglobin) if pneumonectomy planned or likely after induction chemotherapy

Other:

* No clinically significant hearing loss unless willing to accept the potential of further loss
* No symptomatic peripheral neuropathy
* No peptic ulcer disease under active treatment
* No other medical illness not controllable by appropriate medical therapy
* No other malignancy within the past 5 years except adequately treated basal cell or squamous cell skin cancer, carcinoma in situ of the cervix, or ductal or lobular carcinoma in situ of the breast
* Not pregnant or nursing
* Negative pregnancy test
* Fertile patients must use effective contraception

PRIOR CONCURRENT THERAPY:

Biologic therapy:

* No concurrent colony-stimulating factors

Chemotherapy:

* No prior chemotherapy for lung cancer
* No concurrent chemotherapy for another condition (such as arthritis)

Endocrine therapy:

* Not specified

Radiotherapy:

* No prior radiotherapy for lung cancer

Surgery:

* See Disease Characteristics
* No prior resection of primary tumor

Primary outcomes:
measure: Median overall survival
timeFrame: From randomization to date of death or last follow-up. Analysis occurs after patients have been potentially followed for 2.5 years.
Secondary outcomes:
measure: Median Progression-free survival
timeFrame: From randomization to date of death or last follow-up. Analysis occurs after patients have been potentially followed for 2.5 years.
measure: Patterns of local and distant failure
timeFrame: From randomization to date of failure (local, regional or distant progression). Analysis occurs after patients have been potentially followed for 2.5 years.
Other outcomes:
Locations:
city: Urbana
country: United States
facility: CCOP - Carle Cancer Center
state: Illinois
city: Indianapolis
country: United States
facility: Indiana University Cancer Center
state: Indiana
city: Indianapolis
country: United States
facility: Veterans Affairs Medical Center - Indianapolis (Roudebush)
state: Indiana
city: Cedar Rapids
country: United States
facility: CCOP - Cedar Rapids Oncology Project
state: Iowa
city: Ann Arbor
country: United States
facility: CCOP - Ann Arbor Regional
state: Michigan
city: Omaha
country: United States
facility: CCOP - Missouri Valley Cancer Consortium
state: Nebraska
city: Rochester
country: United States
facility: University of Rochester Cancer Center
state: New York
city: Cleveland
country: United States
facility: Ireland Cancer Center
state: Ohio
city: Toledo
country: United States
facility: CCOP - Toledo Community Hospital Oncology Program
state: Ohio
city: Philadelphia
country: United States
facility: Hahnemann University Hospital
state: Pennsylvania
city: Pittsburgh
country: United States
facility: University of Pittsburgh Cancer Institute
state: Pennsylvania
city: Nashville
country: United States
facility: Vanderbilt-Ingram Cancer Center
state: Tennessee
city: Green Bay
country: United States
facility: CCOP - Green Bay
state: Wisconsin
city: Milwaukee
country: United States
facility: Medical College of Wisconsin
state: Wisconsin
city: Milwaukee
country: United States
facility: Veterans Affairs Medical Center - Milwaukee (Zablocki)
state: Wisconsin
city: Pretoria
country: South Africa
facility: Pretoria Academic Hospitals
Study officials:
affiliation: Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
name: David S. Ettinger, MD
role: STUDY_CHAIR
affiliation: Loyola University
name: Kathy S. Albain, MD
role: PRINCIPAL_INVESTIGATOR
affiliation: Vanderbilt-Ingram Cancer Center
name: David H. Johnson, MD
role: STUDY_CHAIR
affiliation: Dana-Farber Cancer Institute
name: Bruce E. Johnson, MD
role: STUDY_CHAIR
affiliation: Medical University of South Carolina
name: Mark R. Green, MD
role: STUDY_CHAIR
affiliation: Mayo Clinic
name: Robert C. Miller, MD
role: STUDY_CHAIR
affiliation: L'Hopital Laval
name: Yvon Cormier, MD
role: STUDY_CHAIR
References:
citation: Machtay M, Bae K, Movsas B, Paulus R, Gore EM, Komaki R, Albain K, Sause WT, Curran WJ. Higher biologically effective dose of radiotherapy is associated with improved outcomes for locally advanced non-small cell lung carcinoma treated with chemoradiation: an analysis of the Radiation Therapy Oncology Group. Int J Radiat Oncol Biol Phys. 2012 Jan 1;82(1):425-34. doi: 10.1016/j.ijrobp.2010.09.004. Epub 2010 Oct 25.
citation: Machtay M, Swann S, Komaki R, et al.: What is the meaning of local-regional control after chemoradiation for locally advanced NSCLC? An RTOG analysis. [Abstract] Lung Cancer 50 (Suppl 2): A-O-041, S17, 2005.
citation: Albain KS, Swann RS, Rusch VW, Turrisi AT 3rd, Shepherd FA, Smith C, Chen Y, Livingston RB, Feins RH, Gandara DR, Fry WA, Darling G, Johnson DH, Green MR, Miller RC, Ley J, Sause WT, Cox JD. Radiotherapy plus chemotherapy with or without surgical resection for stage III non-small-cell lung cancer: a phase III randomised controlled trial. Lancet. 2009 Aug 1;374(9687):379-86. doi: 10.1016/S0140-6736(09)60737-6. Epub 2009 Jul 24.
citation: Albain KS, Swann RS, Rusch VR, et al.: Phase III study of concurrent chemotherapy and radiotherapy (CT/RT) vs CT/RT followed by surgical resection for stage IIIA(pN2) non-small cell lung cancer (NSCLC): outcomes update of North American Intergroup 0139 (RTOG 9309). [Abstract] J Clin Oncol 23 (Suppl 16): A-7014, 624s, 2005.
citation: Albain KS, Scott CB, Rusch VR, et al.: Phase III comparison of concurrent chemotherapy plus radiotherapy (CT/RT) and CT/RT followed by surgical resection for stage IIIA(pN2) non-small cell lung cancer (NSCLC): initial results from intergroup trial 0139 (RTOG 93-09) . [Abstract] Proceedings of the American Society of Clinical Oncology 22: A-2497, 2003.
citation: Turrisi AT, Scott CB, Rusch VR, et al.: Randomized trial of chemoradiotherapy to 61 Gy [no S] versus chemoradiotherapy to 45 Gy followed by surgery [S] using cisplatin etoposide in stage IIIa non-small cell lung cancer (NSCLC): intergroup trial 0139, RTOG (9309). [Abstract] Int J Radiat Oncol Biol Phys 57 (2 Suppl): S125-6, 2003.