Clinical trial NCT05560880: High Intensity Interval Gait Training in Multiple Sclerosis
Official title: The Effects of High Intensity Interval Gait Training vs. Moderate Intensity Continuous Gait Training in Multiple Sclerosis
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Multiple Sclerosis
Lead sponsor: Hunter College of City University of New York
Sponsor class: OTHER
First posted: 2022-09-30
Enrollment: 30
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: Over 90% of persons with MS (pwMS) complain of difficulty with walking. High intensity interval gait training (HIIGT), where persons alternate brief periods of walking at high speeds with periods of rest has been found to improve walking in other neurologic diagnoses. However its impact on pwMS is not known. Most gait training in MS is done continuously at a slower pace. The purpose of this study is to compare the effects of HIIGT to traditional Moderate Intensity Continuous Gait Training (MICGT) in pwMS.

Detailed description: Purpose: To determine whether pwMS will have greater improvements in gait with HIIGT as compared to MICGT.

Primary Question: Does HIIGT results in greater improvements in gait parameters in pwMS than MICGT? Secondary question: Will HIIGT result in greater improvements in balance, lower extremity strength, lower extremity range of motion and HR when compared to MICGT in pwMS?

Hypothesis: HIIGT will result in greater improvements in gait parameters in pwMS than MICGT.

Justification: Previous research has shown that MICGT, moderate intensity interval training and high intensity non-gait interval training is effective in pwMS. HIIGT has been shown to be effective in persons with stroke but the effects of HIIGT on pwMS are not known.

Outcomes and dissemination of information: We will present our findings at national conferences and submit manuscripts of our findings to the appropriate peer reviewed journal.

Eligibility criteria: Inclusion Criteria:

* Persons diagnosed with Multiple Sclerosis.
* The ability to walk for 6 minutes continuously with or without assistive device.
* The ability to read, understand and sign a consent form so that they are able to understand the study we are doing
* Above the age of 18

Exclusion Criteria:

* Any cardiopulmonary, orthopedic, or non-MS neurologic disease as we are only examining the effects of MS and need to rule out the impact of other conditions
* Report of a recent exacerbation. Rationale: the impact of the rationale can interfere with the impact of the independent variables

Primary outcomes:
measure: Change in Six minute walk test time from before to after the intervention
timeFrame: The test will be administered to all subjects one week before and one week after the intervention.The test will be administered to all subjects one week before and one week after the intervention.
Secondary outcomes:
measure: Change in Functional gait assessment score from before to after the intervention
timeFrame: Will be done in the week before and the week after the intervention.Will be done in the week before and the week after the intervention.
measure: Change in Hand held dynamometry values from before to after the intervention
timeFrame: Will be done the week before and the week after the intervention.
measure: Change in Multiple sclerosis impact scale 29 from before to afterthe intervention
timeFrame: Performed in the week before and the week after the intervention.
Other outcomes:
Locations:
city: New York
country: United States
facility: Hunter College
state: New York
Study officials:
References: