Clinical trial NCT02629588: Effectiveness of Sensory Stimulation for Person in a Coma or Persistent Vegetative State After Traumatic Brain Injury
Official title: Effectiveness of Sensory Stimulation for Person in a Coma or Persistent Vegetative State After Traumatic Brain Injury
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Brain Injuries
Keywords: Coma
Persistent Vegetative State
Sensory Stimulation
Lead sponsor: Creighton University
Sponsor class: OTHER
First posted: 2015-12-14
Enrollment: 9
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Time perspective: RETROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: Persons in a coma or persistent vegetative state (Glasgow Coma Scale below 8) after traumatic brain injury

Brief summary: Appraised the empirical evidence of effectiveness of sensory stimulation to improve arousal and alertness for persons in a coma or persistent vegetative state after traumatic brain injury (TBI). Databases were searched and nine articles met inclusion criteria.

Detailed description: Background: Traumatic brain injury (TBI) accounts for approximately 50,000 deaths in the United States each year. About 17% of survivors have a period of "coma". Duration of coma contributes significantly to functional outcomes.

Objective: To appraise the evidence of effectiveness of sensory stimulation to improve arousal and alertness for persons in a coma or persistent vegetative state after TBI.

Data Sources and Study Eligibility Criteria: Databases searched included Medline, PsycINFO, CINAHL, OTseeker, and the Cochrane Database of Systematic Reviews. The search was limited to outcomes studies in the hierarchy described by Sackett and colleagues (1996), published in English in peer-reviewed journals between 2006 and 2014.

Eligibility criteria: Inclusion Criteria:

* in coma or persistent vegetative state after traumatic brain injury

Exclusion Criteria:

* coma or persistent vegetative state not caused by traumatic brain injury

Primary outcomes:
measure: Glasgow Coma Scale
timeFrame: 0-30 days post injury
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
affiliation: Creighton University
name: Rene L Padilla, PhD
role: PRINCIPAL_INVESTIGATOR
References:
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citation: Padilla R, Domina A. Effectiveness of Sensory Stimulation to Improve Arousal and Alertness of People in a Coma or Persistent Vegetative State After Traumatic Brain Injury: A Systematic Review. Am J Occup Ther. 2016 May-Jun;70(3):7003180030p1-8. doi: 10.5014/ajot.2016.021022.