louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT05473988: Optimization of Treatment Priority of the Manchester Triage System
Official title: Optimization of Treatment Priority of the Manchester Triage System
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Triage
Lead sponsor: Kepler University Hospital
Sponsor class: OTHER
First posted: 2022-07-26
Enrollment: 77976
Sex: ALL
Minimum age (years): 18
Maximum age (years): 120
Standard ages: ADULT
OLDER_ADULT
Observational model: COHORT
Time perspective: RETROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: As described in the inclusion criteria.

Brief summary: In the emergency department, the urgency for treating patients is determined according to the Manchester Triage System. The parameters collected in this process are deterministically translated into a treatment priority.

The Manchester Triage System (MTS), which has been in use for at least 20 years, is a widely used, validated and standardized procedure for initial assessment in the emergency department - this initial assessment (triage) is done to prioritize medical assistance at a central point. Especially in emergency situations, critically endangered patients often require the deployment of a large part of the available staff at the same time - the medically correct triage of patients according to objective criteria in order to enable an adequate allocation of the available resources at the right time is the main objective. In the optimal case, each patient is treated by medical professionals within the time frame that is adequate for his/her health condition.

Using artificial intelligence methods, it may be possible to increase the accuracy of treatment priority assignment. In the best case, incorrect prioritization of patients can be prevented and medical care can be ensured for those patients who actually need it most urgently.

However, initial assessment, even if standardized and validated, still runs under limited resource conditions - time, space, material and personnel. Last but not least, the very idea of conducting an initial assessment limits its validity, and the results of the allocation fluctuate according to current research, although the determinants of this are currently unknown.


Eligibility criteria: Inclusion Criteria:

* All adult patients that were triaged at the emergency department at the Kepler University Hospital in the period between 2015-12-01 to 2020-08-31.

Exclusion Criteria:

* None.

Primary outcomes:
measure: AUROC for Classification of Admission to General Ward
timeFrame: 2015-12-01 to 2020-08-31
measure: AUROC for Classification of Admission to Intensive Care Unit
timeFrame: 2015-12-01 to 2020-08-31
measure: AUROC for Classification of 30 Day Mortality
timeFrame: 2015-12-01 to 2020-08-31
Secondary outcomes:
measure: Confusion Matrix
timeFrame: 2015-12-01 to 2020-08-31
Other outcomes:
Locations:
city: Linz
country: Austria
facility: Kepler University Hospital
state: Upper Austria
Study officials:
affiliation: Kepler University Hospital and Johannes Kepler University, Linz, Austria
name: Thomas Tschoellitsch, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT05818488: The Effect of a Mind-body Exercise Program on Aspects of Attention in Individuals With Anxiety
Official title: The Effect of a Mind-body Exercise Program on Aspects of Attention in Individuals With Anxiety: Protocol for a Randomized Controlled Trial
Study type: INTERVENTIONAL
Overall status: NOT_YET_RECRUITING
Phase: NA
Conditions: Anxiety Disorder
Lead sponsor: Universidade Federal do Rio de Janeiro
Sponsor class: OTHER
First posted: 2023-04-18
Enrollment: 16
Sex: ALL
Minimum age (years): 40
Maximum age (years): 75
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: CROSSOVER
Primary purpose: OTHER

Brief summary: Mind-body exercises is a non-pharmacological intervention to mental health and can improve interoceptive capacity. Interoceptive is linked to the process of sensory information within the body playing an important role in behavior. Consequently, interoceptive can be modulated by mind-body training through sustained attention to breathing signals, certainty of movements, and also related to activation of brain processes. The present study aimed to evaluation the effect of mind-body in interoceptive capacity in individuals with anxiety. An anamnesis will be performed with demographic data, as well as questions about medications and physical and mental health history. After that, subjects will be randomized into an intervention (one session of mind-body exercises) where they will be asked to sit in a comfortable armchair and remain in a comfortable posture with their eyes closed. A meditation will be guided by an audio through headphones. The audio will last 15 minutes with an initial invitation to centering (full attention to the state of the body and the breath, bringing the attention to the present moment), followed by a body scan considering the seven dimensions of interoceptive capacity (noticing, not being distracted, not worrying, attentional regulation, emotional awareness, self-regulation, and trust) and the passive control group (waiting room), after the intervention the same cognitive tests will be reapplied. Then, the groups will be switched for a crossover analysis.


Eligibility criteria: Inclusion Criteria:

* clinical diagnosis of anxiety
* must be able to understand procedures

Exclusion Criteria:

* Clinical diagnosis of Alzheimer's Disease

Primary outcomes:
measure: interoceptive capacity.
timeFrame: 15 minutes after the intervention
measure: Anxiety symptoms
timeFrame: 15 minutes after the intervention
measure: Concentrated attention test
timeFrame: 15 minutes after the intervention
measure: Digit Span test
timeFrame: 15 minutes after the intervention
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
References:
Clinical trial NCT03817788: Randomized Controlled Trail of Polyethylene Glycol vs Sodium Phosphate for Colonic Cleansing of Colonoscopy
Official title: Randomized Controlled Trail of Polyethylene Glycol vs Sodium Phosphate for Colonic Cleansing of Colonoscopy
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE4
Conditions: Polyethylene Glycol
Sodium Phosphate
Lead sponsor: Jilin University
Sponsor class: OTHER
Collaborators: name: Xu Hong
First posted: 2019-01-25
Enrollment: 586
Sex: ALL
Minimum age (years): 18
Maximum age (years): 60
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: DIAGNOSTIC

Brief summary: This study is to compare polyethylene glycol and sodium phosphate for colonic cleansing of colonoscopy.


Eligibility criteria: Inclusion Criteria:

* Outpatients meet the following criteria: 1) age 18-60 years; 2) BMI 18.9-28; 3) Heart, lung, liver, and kidney function can tolerate colonoscopy; 4) Patients and their families are able to understand and be willing to participate in this clinical study and to sign informed consent

Exclusion Criteria:

* 1) colorectal surgery history (except appendectomy); 2) patients with intestinal obstruction, incomplete obstruction, intestinal hemorrhage; 3) patients with renal insufficiency; 4) patients with hirschsprung disease; 5) patients with inflammatory bowel disease during active period, which affects intestinal observation; 6) patients who are bedridden and lose the moving ability ; 7) have a history of severe mental illness; 8) pregnant or lactating women; 9) patients with other clinical conditions considered by some researchers should not participate in the trial.

Primary outcomes:
measure: Cleansing quality
timeFrame: during the procedure of colonoscopy
Secondary outcomes:
measure: the duration of the procedure
timeFrame: during the procedure of colonoscopy
measure: patient tolerance
timeFrame: before the procedure of colonoscopy
measure: the degree of difficulty of the procedure
timeFrame: at the end of the procedure of colonoscopy
measure: polyps or other endoscopic lesions
timeFrame: at the end of the procedure of colonoscopy
measure: patient pain
timeFrame: at the end of the procedure of colonoscopy
Other outcomes:
Locations:
city: Chang chun
country: China
facility: the First Hospital of Jilin University
state: Jilin
Study officials:
References:
Clinical trial NCT03378609: Prevalidation of the First German Version of the Vocal Fatigue Index (VFI)
Official title: Prevalidation of the First German Version of the Vocal Fatigue Index (VFI)"
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Vocal Fatigue
Lead sponsor: University of Zurich
Sponsor class: OTHER
First posted: 2017-12-20
Enrollment: 81
Sex: ALL
Minimum age (years): 18
Maximum age (years): 99
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SEQUENTIAL
Primary purpose: HEALTH_SERVICES_RESEARCH

Brief summary: Vocal fatigue has been described as a common complaint in patients with voice disorders, however to date there is no standardized questionnaire in german language to assess specific symptoms. Main aim of this study is to assess the validity of the first german version of the Vocal Fatigue Index (VFI), and english questionnaire developed for voice patients to assess vocal fatigue.

In this study patients with voice disorders will receive the patient based questionnaires "Vocal Fatigue Index (VFI)", "Voice Handicap Index 9 international (VHI 9i)" and "Vocal Tract Discomfort Scale (VTD)", the study information and consent letter together with the standard invitation letter to a voice assessment at the Department for Phoniatrics and Speech Pathology University Hospital Zurich. Data of 93 consecutive volunteering patients will be collected. Furthermore a retest using the VFI will be conducted after 1 week with 10 volunteers. Thereafter construct validity of the VFI as compared to the established voice symptom questionnaires VHI 9i and VTD will be investigated. Further test-retest reliability will be determined.


Eligibility criteria: Inclusion Criteria:

* age \> 18 years
* voice disorder (all etiologies)

Exclusion Criteria:

* age \< 18 Jahre
* current voice therapy
* psychological disease
* botox injection in the Larynx
* inability to independently fill out the questionnaire

Primary outcomes:
measure: Validity of the first German version ot the Vocal Fatigue Index (VFI) compared to the VHI9i and VTD
timeFrame: one day
Secondary outcomes:
measure: Reliability of the first German version ot the Vocal Fatigue Index (VFI) compared to the VHI9i and VTD
timeFrame: one day
Other outcomes:
Locations:
city: Zürich
country: Switzerland
facility: ORL Klinik
Study officials:
References:
Clinical trial NCT00311909: Thalamic Deep Brain Stimulation for Tourette Syndrome
Official title: Thalamic Deep Brain Stimulation for Tourette Syndrome: A Prospective Clinical Trial
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE2
Conditions: Tourette Syndrome
Keywords: Tourette Syndrome
Deep Brain Stimulation
Video assessment
YGTSS
TSSL
Lead sponsor: University Hospitals Cleveland Medical Center
Sponsor class: OTHER
Collaborators: name: Medtronic
First posted: 2006-04-06
Enrollment: 5
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: CROSSOVER
Primary purpose: TREATMENT

Brief summary: The purpose of this study is to determine whether deep brain stimulation is effective at reducing tic frequency and severity in adults with Tourette syndrome.


Eligibility criteria: Inclusion Criteria:

* age 18 or older
* Diagnosis of Tourette Syndrome by DSM-IV
* Tic frequency at least one per minute at screening
* prior failure of at least two dopamine receptor or presynaptic blockers
* negative impact on quality of life

Exclusion Criteria:

* significant structural brain lesion (on imaging studies)
* significant dementia
* severe head trauma preceding onset of tics
* use of dopamine receptor blockers prior to recognition of tics
* prior implanted electrical device
* electroconvulsive therapy (ECT) within 24 months
* suicide attempt within 12 months
* significant sociopathic personality
* current or planned pregnancy

Primary outcomes:
measure: modified Rush Video Rating Scale (mRVRS)
Secondary outcomes:
measure: tic counts (on video recording)
measure: Yale Global Tourette Severity Scale (YGTSS)
measure: Tourette Syndrome Symptom List (TSSL)
measure: Quality of Life Visual Analog Scale (VAS)
measure: SF-36
measure: Neuropsychological battery
Other outcomes:
Locations:
city: Cleveland
country: United States
facility: University Hospitals of Cleveland
state: Ohio
Study officials:
affiliation: University Hospitals Cleveland Medical Center
name: Robert J Maciunas, MD MPH FACS
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT05085509: Foreign Body Removal With the Assistance of Ultrasound Guidance and Methylene Blue Staining in Children
Official title: Foreign Body Removal With the Assistance of Ultrasound Guidance and Methylene Blue Staining
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Foreign Bodies
Ultrasound
Lead sponsor: Children's Hospital of Chongqing Medical University
Sponsor class: OTHER
First posted: 2021-10-20
Enrollment: 50
Sex: ALL
Minimum age (years): 1
Maximum age (years): 18
Standard ages: CHILD
ADULT
Accepts healthy volunteers: no
Allocation: NON_RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: Soft-tissue foreign bodies (FB) are very commonly observed in pediatric emergency departments. Some are metallic and can be diagnosed easily via X-ray radiography, whereas others are radiolucent and are hence less easily diagnosed. Not all FB can be removed effectively, even via open surgery and C-arm guidance. This deficiency may potentially be addressed through the ultrasound (US) skills instrument, which is increasingly popular and is convenient for use in the operation room. In the current study, we evaluated the efficiency of FB removal with the assistance of US and methylene blue (MB) staining.


Eligibility criteria: Inclusion Criteria:

* Diagnosed with soft-tissue foreign body
* Must have complete clinical data

Exclusion Criteria:

* Had other injuries
* Presented with more than 3 pieces foreign bodies

Primary outcomes:
measure: Surgery time
timeFrame: Surgery end time
Secondary outcomes:
measure: Blood loss
timeFrame: Surgery end time
Other outcomes:
Locations:
city: Chongqing
country: China
facility: Children's Hospital of Chongqing Medical University
state: Chongqing
Study officials:
References:
Clinical trial NCT01917409: Video-stylet for Nasotracheal Intubation
Official title: Comparison of Conventional Laryngoscopy and Video-stylet to Assist Nasotracheal Intubation for Patients Undergoing Oro-Maxillo-facial Surgery
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Intubation, Difficult
Keywords: Conventional Laryngoscopy ,
Video-stylet ,
Nasotracheal Intubation
Lead sponsor: Kaohsiung Medical University Chung-Ho Memorial Hospital
Sponsor class: OTHER
First posted: 2013-08-06
Enrollment: 100
Sex: ALL
Minimum age (years): 20
Maximum age (years): 65
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The purpose of this study is to compare conventional laryngoscopy with video-stylet (Trachway) for nasotracheal intubation in patients undergoing oro-maxillo-facial surgery.


Eligibility criteria: Inclusion Criteria:

1. patients with American Society of Anesthesiologists physical status I-III
2. aged 20-65 years
3. Requiring Nasotracheal Intubation under general anesthesia
4. unlimited mouth open
5. unlimited neck motion

Exclusion Criteria:

1. mouth open \< 3 cm
2. Ankylosing arthritis patients.
3. BMI≧35 kg/m2

Primary outcomes:
measure: number of the patients with successful nasotracheal intubation and scoring difficult intubation scale
timeFrame: half an hour
Secondary outcomes:
measure: time to intubate
timeFrame: 10 minutes
Other outcomes:
measure: postoperative nasal bleeding, sore throat and hoarseness
timeFrame: 2 days
Locations:
city: Kaohsiung
country: Taiwan
facility: Kaohsiung Medical University Chung-Ho Memorial Hospital
Study officials:
affiliation: Department of anesthesiology, Kaohsiung Medical University, Taiwan
name: Kuang I Cheng, MD., PhD.
role: STUDY_DIRECTOR
References:
citation: Hsu HT, Lin CH, Tseng KY, Shen YC, Chen CH, Chuang WM, Cheng KI. Trachway in assistance of nasotracheal intubation with a preformed nasotracheal tube in patients undergoing oral maxillofacial surgery. Br J Anaesth. 2014 Oct;113(4):720-1. doi: 10.1093/bja/aeu334. No abstract available.
Clinical trial NCT01462409: Humidity Under Continuous Positive Airway Pressure
Official title: Luftfeuchtigkeit Unter CPAP Mit Temperatur- Und Feuchtigkeitskontrolle
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Sleep Apnea, Obstructive
Keywords: obstructive sleep apnea
humidification
mask
heated tubing
Lead sponsor: Institut für Pneumologie Hagen Ambrock eV
Sponsor class: INDUSTRY
Collaborators: name: ResMed GmbH & Co KG
First posted: 2011-10-31
Enrollment: 19
Sex: MALE
Minimum age (years): 20
Maximum age (years): 70
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: CROSSOVER
Primary purpose: TREATMENT

Brief summary: Heated humidification in CPAP therapy is often not enough to prevent side effects like dryness of nasal mucosa and xerostomia, especially in cases of mouth breathing or mask leakage. Additionally a higher level of humidification in lower ambient room temperature can lead to condensation and irritating noises. Compliance of affected patients decreases considerably. Regarding this, devices with humidifier and additional heated tubing are developed to automatically regulate optimal humidification and temperature right up to the mask. The efficacy of a system with controlled heated humidification and heated tubing in nasal masks under various conditions like leakage and different pressure levels is object of this study.

Detailed description: Participants will breath 3 hours during daytime with a nasal mask under three different humidity modes (No humidity, controlled heated humidification, controlled heated humidification with heated tubing) with CPAP 8 and 12 mmHg and with and without leakage. The ambient room temperature is controlled with air conditioning. Changes in temperature and humidity is measured inside of the mask with a humidity sensor and recorded. After each phase the participants subjective opinion about humidity and temperature is asked.

Eligibility criteria: Inclusion Criteria:

* Age 20-70
* Obstructive Sleep Apnoea Syndrome

Exclusion Criteria:

* Other severe acute or chronic nasal disease (rhinitis, sinusitis), Cardiovascular disease, respiratory or neurologic disease
* Incapable of giving consent

Primary outcomes:
measure: Humidity differences
timeFrame: 3 hours per patient
Secondary outcomes:
Other outcomes:
Locations:
city: Hagen
country: Germany
facility: Helios Klinik Hagen Ambrock
state: NRW
Study officials:
affiliation: Institut für Pneumologie Hagen Ambrock eV
name: Karl Heinz Ruehle, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT01203709: Low-dose Combination of Mycophenolate Mofetil (MMF) and Tacrolimus (Tac) for Refractory Lupus Nephritis
Official title: Low-dose Combination of Mycophenolate Mofetil and Tacrolimus for Refractory Lupus Nephritis: a 12-month Prospective Study
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE4
Conditions: Lupus Nephritis
Keywords: lupus
nephritis
glomerulonephritis
nephropathy
refractory
Lead sponsor: Tuen Mun Hospital
Sponsor class: OTHER_GOV
First posted: 2010-09-16
Enrollment: 20
Sex: ALL
Minimum age (years): 18
Maximum age (years): 80
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: TREATMENT

Brief summary: A trial of combination of two drugs for the treatment of refractory lupus nephritis.

Detailed description: Low-dose combination of mycophenolate mofetil and tacrolimus for refractory lupus nephritis: a 12-month prospective study

Eligibility criteria: Inclusion Criteria:

1. Active nephritis documented by renal biopsy within 24 months of entry;
2. Failure to respond to 2 or more immunosuppressive regimens which consisted of high-dose prednisolone combined with other non-corticosteroid immunosuppressive agents together with ACE inhibitors plus or minus angiotensin receptor blockers (ARB) for at least 4 months for each regimen at the maximally tolerated drug dosages;
3. Serum creatinine (Scr) less than 200umol/L.

Exclusion Criteria:

1. Previous intolerance to either MMF/Tac;
2. Scr \>200umol/L;
3. Informed consent unavailable.

Primary outcomes:
measure: Clinical remission rate
timeFrame: 12 months
Secondary outcomes:
measure: Adverse events
timeFrame: 12 months
Other outcomes:
Locations:
city: Hong Kong
country: China
facility: Tuen Mun Hospital
Study officials:
affiliation: Tuen Mun Hospital, Hong Kong China
name: CC Mok, MD, FRCP
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT04877509: Micronutrient Status Involved in Immunity in Elderly Patients With COVID-19
Official title: Micronutrient Status Involved in Immunity in Elderly Patients With COVID-19
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Covid19
Keywords: Covid19
Micronutriments
Elderly
Lead sponsor: Hospices Civils de Lyon
Sponsor class: OTHER
First posted: 2021-05-07
Enrollment: 229
Sex: ALL
Minimum age (years): 50
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: OTHER
Sampling method: NON_PROBABILITY_SAMPLE
Study population: This is an observational study based on a monocentric historical cohort of ≥ 50 years patients hospitalized at HCL from 1st March 2020 to 30th May 2020and suffering from COVID-19.

Brief summary: During the ongoing COVID-19 pandemic, age was clearly the major factor of mortality. Increasing age was strongly associated with this risk, with the upper 80 years age group having more than 12-fold increased risk compared with those aged 50-59 years. Male gender was also associated with a doubling of risk.

The elderly subject is particularly exposed to global denutrition with risk of micronutrients deficiencies such as vitamins and trace elements. Those deficits expose to lower immunity. In addition, viral infection as COVID-19 can also worsen these deficits.

In general, low levels or intakes of micronutrients such as Zn, Se and vitamin A have been associated with adverse clinical outcomes during viral infections. This notion has been confirmed in a recent review proposing that besides vitamins A and D also B vitamins, vitamin C, omega-3 polyunsaturated fatty acids, as well as selenium, zinc and iron should be considered in the assessment of micronutrients in COVID-19 patients.

In this context, the MicroCovAging study will evaluate copper, zinc and selenium, vitamin A, D and E status in elderly subjects affected by COVID- 19 and to correlate this status with prognosis of this disease.


Eligibility criteria: Inclusion Criteria:

* Hospitalized adult patient ≥ 50 years at the time of admission,
* Suffering from confirmed COVID-19 (positive quantitative PCR for SARS-CoV-2 and/or chest scanner suggestive of COVID-19),
* Informed and non-opposed to the research. Patient will be informed of the study by his medical doctor during hospitalization or by post thanks to a generic information sheet dedicated to COVID-19 researches.

Exclusion Criteria:

* Adult patient \< 50 years at the time of admission
* Negative quantitative PCR for SARS-Cov-2

Primary outcomes:
measure: Selenium, Zinc and Copper, Vitamin A, D and E plasma concentrations of 229 over 50 year's patients hospitalized suffering from COVID-19.
timeFrame: Up to 3 months
Secondary outcomes:
Other outcomes:
Locations:
city: Pierre-Bénite
country: France
facility: Chls Cbap
Study officials:
References: