Clinical trial NCT06597370: Immunogenicity Induced by COVID-19 Vaccines in Mexican Population
Official title: Immunogenicity Induced by COVID-19 Vaccines in Mexican Population: mRNA Expression for IgG Anti-spike
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: COVID-19 Vaccine
Lead sponsor: National Polytechnic Institute, Mexico
Sponsor class: OTHER
First posted: 2024-09-19
Enrollment: 80
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: OTHER
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Mexican men and women over 18 years of age, vaccinated in the last 4 months

Brief summary: To determine the gene expression of anti-spike IgG through PCR-RT in patients vaccinated with the 4 types of vaccines available in Mexico Oxford/AstraZeneca (ChAdOx1 nCoV-19), Centro Nacional Gamaleya (Sputnik V), Pfizer/BioNTech (BNT162b2) and Sinovac (CoronaVac).

Detailed description: 80 subjects with full vaccination schedule will be included, 20 per group To know the gene expression of IgG anti-spike through PCR-RT in patients vaccinated with the 4 types of vaccines available in Mexico Oxford/AstraZeneca (ChAdOx1 nCoV-19), Centro Nacional Gamaleya (Sputnik V), Pfizer/BioNTech (BNT162b2) and Sinovac (CoronaVac).

Eligibility criteria: Inclusion Criteria:

1. - Mexican people.
2. - Over 18 years of age.
3. - With complete vaccination schedule against COVID-19.
4. - Allowing peripheral blood samples to be taken.
5. - To sign an informed consent form.
6. - To agree to participate in the protocol.

Exclusion Criteria:

1. - Persons with incomplete vaccination schedule against COVID-19.
2. - Persons who have 30 +/- 5 days of having completed the vaccination scheme against COVID-19.
3. - People under treatment with any immunosuppressive drug.
4. People who refuse to sign the informed consent form.

Primary outcomes:
measure: Immunogenicity induced by COVID-19 vaccines in Mexican population
timeFrame: 4 months
Secondary outcomes:
Other outcomes:
Locations:
city: Mexico City
country: Mexico
facility: Escuela Superior de Medicina, Instituto Politécnico Nacional
Study officials:
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