Clinical trial NCT01885078: An Extension Study in Participants With Moderate to Severe Rheumatoid Arthritis
Official title: A Phase 3, Multicenter Study to Evaluate the Long-Term Safety and Efficacy of Baricitinib in Patients With Rheumatoid Arthritis
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE3
Conditions: Rheumatoid Arthritis
Lead sponsor: Eli Lilly and Company
Sponsor class: INDUSTRY
First posted: 2013-06-24
Enrollment: 2877
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The purpose of this study is to investigate the long-term safety and any side effects of baricitinib in participants who have completed a previous baricitinib rheumatoid arthritis study.

The study provides 7 years of additional treatment with baricitinib.


Eligibility criteria: Inclusion Criteria:

* Have completed the final active treatment in study JADV (NCT01710358), JADZ (NCT01711359), JADX (NCT01721057), JADW (NCT01721044), JADA (NCT01185353) or JAGS (NCT02265705)

Exclusion Criteria:

* Have significant uncontrolled cerebro-cardiovascular (eg, myocardial infarction \[MI\], unstable angina, unstable arterial hypertension, severe heart failure, or cerebrovascular accident), respiratory, hepatic, renal, gastrointestinal, endocrine, hematologic, neuropsychiatric disorders, or abnormal laboratory values that developed during a previous baricitinib study that, in the opinion of the investigator, pose an unacceptable risk to the participant if investigational product continues to be administered
* Have a known hypersensitivity to baricitinib or any component of this investigational product
* Had investigational product permanently discontinued at any time during a previous baricitinib study
* Had temporary investigational product interruption at the final study visit of a previous baricitinib study and, in the opinion of the investigator, this poses an unacceptable risk for participation in the study
* Have any other condition that, in the opinion of the investigator, renders the participant unable to understand the nature, scope, and possible consequences of the study or precludes the participant from following and completing the protocol

Primary outcomes:
measure: Number of Participants Who Experienced Adverse Events (AEs) or Serious AE
timeFrame: Baseline through 84 Months
Secondary outcomes:
measure: Percentage of Participants Maintaining an American College of Rheumatology (ACR) Response of ACR20
timeFrame: Year 1 after entry into JADY
measure: Percentage of Participants Maintaining an American College of Rheumatology (ACR) Response of ACR20
timeFrame: Year 3 after entry into JADY
measure: Percentage of Participants Maintaining an American College of Rheumatology (ACR) Response of ACR20
timeFrame: Year 5 after entry into JADY
measure: Percentage of Participants Maintaining an American College of Rheumatology (ACR) Response of ACR50
timeFrame: Year 1 after entry into JADY
measure: Percentage of Participants Maintaining an American College of Rheumatology (ACR) Response of ACR50
timeFrame: Year 3 after entry into JADY
measure: Percentage of Participants Maintaining an American College of Rheumatology (ACR) Response of ACR50
timeFrame: Year 5 after entry into JADY
measure: Percentage of Participants Maintaining an American College of Rheumatology (ACR) Response of ACR70
timeFrame: Year 1 after entry into JADY
measure: Percentage of Participants Maintaining an American College of Rheumatology (ACR) Response of ACR70
timeFrame: Year 3 after entry into JADY
measure: Percentage of Participants Maintaining an American College of Rheumatology (ACR) Response of ACR70
timeFrame: Year 5 after entry into JADY
measure: Percentage of Participants Maintaining a Disease Activity Score (DAS28) High-Sensitivity C-Reactive Protein (hsCRP) ≤3.2
timeFrame: Year 1 after entry into JADY
measure: Percentage of Participants Maintaining a Disease Activity Score (DAS28) High-Sensitivity C-Reactive Protein (hsCRP) ≤3.2
timeFrame: Year 3 after entry into JADY
measure: Percentage of Participants Maintaining a Disease Activity Score (DAS28) High-Sensitivity C-Reactive Protein (hsCRP) ≤3.2
timeFrame: Year 5 after entry into JADY
measure: Percentage of Participants Maintaining a Disease Activity Score (DAS28) High-Sensitivity C-Reactive Protein (hsCRP)<2.6
timeFrame: Year 1 after entry into JADY
measure: Percentage of Participants Maintaining a Disease Activity Score (DAS28) High-Sensitivity C-Reactive Protein (hsCRP)<2.6
timeFrame: Year 3 after entry into JADY
measure: Percentage of Participants Maintaining a Disease Activity Score (DAS28) High-Sensitivity C-Reactive Protein (hsCRP)<2.6
timeFrame: Year 5 after entry into JADY
measure: Percentage of Participants Maintaining a DAS28-Erythrocyte Sedimentation Rate (ESR) Score of ≤3.2
timeFrame: Year 1 after entry into JADY
measure: Percentage of Participants Maintaining a DAS28-Erythrocyte Sedimentation Rate (ESR) Score of ≤3.2
timeFrame: Year 3 after entry into JADY
measure: Percentage of Participants Maintaining a DAS28-Erythrocyte Sedimentation Rate (ESR) Score of ≤3.2
timeFrame: Year 5 after entry into JADY
measure: Percentage of Participants Maintaining a DAS28-Erythrocyte Sedimentation Rate (ESR) Sore of <2.6
timeFrame: Year 1 after entry into JADY
measure: Percentage of Participants Maintaining a DAS28-Erythrocyte Sedimentation Rate (ESR) Sore of <2.6
timeFrame: Year 3 after entry into JADY
measure: Percentage of Participants Maintaining a DAS28-Erythrocyte Sedimentation Rate (ESR) Sore of <2.6
timeFrame: Year 5 after entry into JADY
measure: Percentage of Participants Maintaining American College of Rheumatology/European League Against Rheumatism (ACR/EULAR) Boolean Remission Response
timeFrame: Year 1 after entry into JADY
measure: Percentage of Participants Maintaining American College of Rheumatology/European League Against Rheumatism (ACR/EULAR) Boolean Remission Response
timeFrame: Year 3 after entry into JADY
measure: Percentage of Participants Maintaining American College of Rheumatology/European League Against Rheumatism (ACR/EULAR) Boolean Remission Response
timeFrame: Year 5 after entry into JADY
measure: Change From Baseline of Originating Study in Modified Total Sharp Score (mTSS)
timeFrame: Baseline, Year 1
measure: Change From Baseline of Originating Study in Modified Total Sharp Score (mTSS)
timeFrame: Baseline, Year 3
measure: Change From Baseline of Originating Study in Modified Total Sharp Score (mTSS)
timeFrame: Baseline, Year 5
measure: Percentage of Participants With mTSS Change ≤0
timeFrame: Year 1 after entry into JADY
measure: Percentage of Participants With mTSS Change ≤0
timeFrame: Year 3 after entry into JADY
measure: Percentage of Participants With mTSS Change ≤0
timeFrame: Year 5 after entry into JADY
measure: Change From Baseline of Originating Study in Joint Space Narrowing at Year 1
timeFrame: Baseline, Year 1
measure: Change From Baseline of Originating Study in Joint Space Narrowing at Year 3
timeFrame: Baseline, Year 3
measure: Change From Baseline of Originating Study in Joint Space Narrowing at Year 5
timeFrame: Baseline, Year 5
measure: Change From Baseline of Originating Study in Duration of Morning Stiffness
timeFrame: Baseline, Year 1
measure: Change From Baseline of Originating Study in Duration of Morning Stiffness
timeFrame: Baseline, Year 3
measure: Change From Baseline of Originating Study in Duration of Morning Stiffness
timeFrame: Baseline, Year 5
measure: Change From Baseline of Originating Study in European Quality of Life-5 Dimensions-5 Level (EQ-5D-5L) Health State Scores
timeFrame: Baseline, Year 1
measure: Change From Baseline of Originating Study in European Quality of Life-5 Dimensions-5 Level (EQ-5D-5L) Health State Scores
timeFrame: Baseline, Year 3
measure: Change From Baseline of Originating Study in European Quality of Life-5 Dimensions-5 Level (EQ-5D-5L) Health State Scores
timeFrame: Baseline, Year 5
measure: Change From Baseline of Originating Study in European Quality of Life-5 Dimensions-5 Level (EQ-5D-5L) Scores (Self-Perceived Health)
timeFrame: Baseline, Year 1
measure: Change From Baseline of Originating Study in European Quality of Life-5 Dimensions-5 Level (EQ-5D-5L) Scores (Self-Perceived Health)
timeFrame: Baseline, Year 3
measure: Change From Baseline of Originating Study in European Quality of Life-5 Dimensions-5 Level (EQ-5D-5L) Scores (Self-Perceived Health)
timeFrame: Baseline, Year 5
measure: Percentage of Participants Maintaining a Clinical Disease Activity Index Score (CDAI) ≤10
timeFrame: Year 1 after entry into JADY
measure: Percentage of Participants Maintaining a Clinical Disease Activity Index Score (CDAI) ≤10
timeFrame: Year 3 after entry into JADY
measure: Percentage of Participants Maintaining a Clinical Disease Activity Index Score (CDAI) ≤10
timeFrame: Years 5 after entry into JADY
measure: Percentage of Participants Maintaining a Clinical Disease Activity Index Score (CDAI) ≤ 2.8
timeFrame: Year 1 after entry into JADY
measure: Percentage of Participants Maintaining a Clinical Disease Activity Index Score (CDAI) ≤2.8
timeFrame: Year 3 after entry into JADY
measure: Percentage of Participants Maintaining a Clinical Disease Activity Index Score (CDAI) ≤2.8
timeFrame: Year 5 after entry into JADY
measure: Percentage of Participants Maintaining a Health Assessment Questionnaire Disability Index (HAQ-DI) Improvement ≥0.22
timeFrame: Year 1 after entry into JADY
measure: Percentage of Participants Maintaining a Health Assessment Questionnaire Disability Index (HAQ-DI) Improvement ≥0.22
timeFrame: Year 3 after entry into JADY
measure: Percentage of Participants Maintaining a Health Assessment Questionnaire Disability Index (HAQ-DI) Improvement ≥0.22
timeFrame: Year 5 after entry into JADY
measure: Percentage of Participants Maintaining a Health Assessment Questionnaire Disability Index (HAQ-DI) Improvement ≥0.3
timeFrame: Year 1 after entry into JADY
measure: Percentage of Participants Maintaining a Health Assessment Questionnaire Disability Index (HAQ-DI) Improvement ≥0.3
timeFrame: Year 3 after entry into JADY
measure: Percentage of Participants Maintaining a Health Assessment Questionnaire Disability Index (HAQ-DI) Improvement ≥0.3
timeFrame: Year 5 after entry into JADY
measure: Change From Baseline of Originating Study in Bone Erosion Score
timeFrame: Baseline, Year 1
measure: Change From Baseline of Originating Study in Bone Erosion Score
timeFrame: Baseline, Year 3
measure: Change From Baseline of Originating Study in Bone Erosion Score
timeFrame: Baseline, Year 5
measure: Healthcare Resource Utilization
timeFrame: Baseline up to 84 Months
measure: Percentage of Participants Maintaining a Simplified Disease Activity Index (SDAI) ≤11
timeFrame: Year 1 after entry into JADY
measure: Percentage of Participants Maintaining a Simplified Disease Activity Index (SDAI) ≤11
timeFrame: Year 3 after entry into JADY
measure: Percentage of Participants Maintaining a Simplified Disease Activity Index (SDAI) ≤11
timeFrame: Year 5 after entry into JADY
measure: Percentage of Participants Maintaining a Simplified Disease Activity Index (SDAI) ≤3.3
timeFrame: Year 1 after entry into JADY
measure: Percentage of Participants Maintaining a Simplified Disease Activity Index (SDAI) ≤3.3
timeFrame: Year 3 after entry into JADY
measure: Percentage of Participants Maintaining a Simplified Disease Activity Index (SDAI) ≤3.3
timeFrame: Year 5 after entry into JADY
measure: Percentage of Participants With Relapse Event During the 96-Week Step-Down Period
timeFrame: Week 0 through Week 96 of Step-down
Other outcomes:
Locations:
city: Glendale
country: United States
facility: Arizona Arthritis & Rheumatology Research, PLLC
state: Arizona
city: Mesa
country: United States
facility: Arizona Arthritis & Rheumatology Associates, P. C.
state: Arizona
city: Peoria
country: United States
facility: Sun Valley Arthritis Center, LTD
state: Arizona
city: Phoenix
country: United States
facility: Arizona Research Center
state: Arizona
city: Tucson
country: United States
facility: University of Arizona
state: Arizona
city: Fresno
country: United States
facility: Valley Endocrine, Fresno
state: California
city: La Jolla
country: United States
facility: Allergy and Rheumatology Medical Clinic Inc
state: California
city: Palm Desert
country: United States
facility: Desert Medical Advances
state: California
city: Palo Alto
country: United States
facility: Stanford University Hospital
state: California
city: Santa Maria
country: United States
facility: Pacific Arthritis Center
state: California
city: Upland
country: United States
facility: Inland Rheumatology & Osteoporosis Medical Group
state: California
city: Boulder
country: United States
facility: Boulder Medical Center
state: Colorado
city: Denver
country: United States
facility: Denver Arthritis Clinic - Lowry
state: Colorado
city: Bridgeport
country: United States
facility: New England Research Associates
state: Connecticut
city: Danbury
country: United States
facility: Clinical Research Center of CT/NY
state: Connecticut
city: Lewes
country: United States
facility: Delaware Arthritis
state: Delaware
city: Boynton Beach
country: United States
facility: Orthopedic Research Institute
state: Florida
city: Naples
country: United States
facility: Medallion Clinical Research Institute
state: Florida
city: New Port Richey
country: United States
facility: Sun Coast Clinical Research, Inc
state: Florida
city: Orlando
country: United States
facility: Omega Research Consultants
state: Florida
city: Orlando
country: United States
facility: Rheumatology Associates of Central Florida
state: Florida
city: Palm Harbor
country: United States
facility: Arthritis Research of Florida
state: Florida
city: Tamarac
country: United States
facility: West Broward Rheumatology Associates, Inc
state: Florida
city: Tampa
country: United States
facility: AdventHealth Medical Group
state: Florida
city: Tampa
country: United States
facility: Tampa Medical Group, P.A.
state: Florida
city: Boise
country: United States
facility: Intermountain Research Center
state: Idaho
city: Vernon Hills
country: United States
facility: Deerbrook Medical Associates
state: Illinois
city: Indianapolis
country: United States
facility: Indiana University Health
state: Indiana
city: Indianapolis
country: United States
facility: Diagnostic Rheumatology and Research
state: Indiana
city: Indianapolis
country: United States
facility: Goldpoint Clinical Research LLC
state: Indiana
city: Cumberland
country: United States
facility: Klein and Associates MD, PA
state: Maryland
city: Grand Rapids
country: United States
facility: West Michigan Rheumatology
state: Michigan
city: Kalamazoo
country: United States
facility: Borgess Rheumatology
state: Michigan
city: Lansing
country: United States
facility: Advanced Rheumatology, PC
state: Michigan
city: Lansing
country: United States
facility: Office: Dr. Fiechtner, Justus
state: Michigan
city: Flowood
country: United States
facility: Arthritis and Osteporosis Treatment and Research Center
state: Mississippi
city: Columbia
country: United States
facility: University of Missouri
state: Missouri
city: Saint Louis
country: United States
facility: Clayton Medical Research
state: Missouri
city: Saint Louis
country: United States
facility: Arthritis Consultants, Inc.
state: Missouri
city: Las Vegas
country: United States
facility: Dr. George Timothy Kelly
state: Nevada
city: Freehold
country: United States
facility: (AOA) Arthritis & Osteoporosis Associates
state: New Jersey
city: Toms River
country: United States
facility: Ocean Rheumatology, PA
state: New Jersey
city: Albuquerque
country: United States
facility: Albuquerque Clinical Trials, Inc.
state: New Mexico
city: Albany
country: United States
facility: The Center for Rheumatology
state: New York
city: Hartsdale
country: United States
facility: Drug Trials of America
state: New York
city: Rochester
country: United States
facility: Allergy Asthma Immunology of Rochester, AAIR Research Ctr
state: New York
city: Asheville
country: United States
facility: Asheville Rheumatology & Osteoporosis Research Assoc, PA
state: North Carolina
city: Charlotte
country: United States
facility: Arthritis and Osteoporosis Consultants of the Carolinas
state: North Carolina
city: Middleburg Heights
country: United States
facility: Paramount Medical Research
state: Ohio
city: Oklahoma City
country: United States
facility: Health Research of Oklahoma
state: Oklahoma
city: Tulsa
country: United States
facility: Healthcare Research Consultant
state: Oklahoma
city: Portland
country: United States
facility: Oregon Health and Science University
state: Oregon
city: Bethlehem
country: United States
facility: East Penn Rheumatology Associates
state: Pennsylvania
city: Duncansville
country: United States
facility: Altoona Center For Clinical Research
state: Pennsylvania
city: Philadelphia
country: United States
facility: Arthritis Group
state: Pennsylvania
city: Wyomissing
country: United States
facility: Clinical Research Center of Reading,LLC
state: Pennsylvania
city: Myrtle Beach
country: United States
facility: Carolina Rheumatology and Neurology Associates
state: South Carolina
city: Cypress
country: United States
facility: Pioneer Research Solutions
state: Texas
city: Dallas
country: United States
facility: Metroplex Clinical Research Center
state: Texas
city: League City
country: United States
facility: Accurate Clinical Research
state: Texas
city: Lubbock
country: United States
facility: Arthritis & Osteoporosis Associates LLP
state: Texas
city: Webster
country: United States
facility: Accurate Clinical Research
state: Texas
city: Chesapeake
country: United States
facility: Center for Arthritis and Rheumatic Diseases, PC
state: Virginia
city: Bothell
country: United States
facility: Western Washington Arthritis Clinic
state: Washington
city: Kennewick
country: United States
facility: Kadlec Clinic Rheumatology
state: Washington
city: Vancouver
country: United States
facility: The Vancouver Clinic
state: Washington
city: Franklin
country: United States
facility: Rheumatology and Immunotherapy Center
state: Wisconsin
city: Bahia Blanca
country: Argentina
facility: Hospital Italiano Regional del Sur
state: Buenos Aires
city: Ciudad Autonoma de Buenos Aire
country: Argentina
facility: Atencion Integral en Reumatología
state: Buenos Aires
city: Mar del Plata
country: Argentina
facility: Instituto de Investigaciones Clínicas Mar del Plata
state: Buenos Aires
city: Mar del Plata
country: Argentina
facility: Centro de Investigaciones Medicas Mar del Plata
state: Buenos Aires
city: Quilmes
country: Argentina
facility: CER Instituto Medico
state: Buenos Aires
city: Quilmes
country: Argentina
facility: Instituto de Investigaciones Clinicas Quilmes
state: Buenos Aires
city: San Isidro
country: Argentina
facility: Instituto Medico de Alta Complejidad San Isidro
state: Buenos Aires
city: Caba
country: Argentina
facility: CENIT Centro de Neurociencias, Investigación y Tratamiento
state: Ciudad Autonoma Buenos Aires
city: Caba
country: Argentina
facility: Instituto Centenario
state: Ciudad Autonoma De Buenos Aire
city: Rosario
country: Argentina
facility: Centro de Enfermedades del Higado y Aparato Digestivo
state: Santa Fe
city: Rosario
country: Argentina
facility: Instituto CAICI SRL
state: Santa Fe
city: San Miguel de Tucuman
country: Argentina
facility: CIR Centro de Investigacions Reumatologicas
state: Tucuman
city: SAN M. DE Tucuman
country: Argentina
facility: Centro Medico Privado de Reumatologia
state: Tucumán
city: Ciudad Autonoma Buenos Aires
country: Argentina
facility: Consultorios Asociados de Endocrinologia
city: Ciudad Autonoma de Buenos Aire
country: Argentina
facility: Organizacion Medica de Investigacion - OMI
city: Ciudad Autonoma de Buenos Aire
country: Argentina
facility: Centro De Osteopatias - Comlit
city: Ciudad Autonoma de Buenos Aire
country: Argentina
facility: Hospital Ramos Mejia
city: Ciudad Autonoma de Buenos Aire
country: Argentina
facility: Centro de Medicina Familiar Mindout Research
city: Ciudad Autonoma de Buenos Aire
country: Argentina
facility: Consultorios Reumatologicos Pampa
city: Ciudad Autonoma de Buenos Aire
country: Argentina
facility: CCBR Buenos Aires
city: Ciudad Autonoma de Buenos Aire
country: Argentina
facility: CEMIC Saavedra
city: Ciudad Autonoma de Buenos Aire
country: Argentina
facility: CENUDIAB
city: Cordoba
country: Argentina
facility: Instituto Medico Strusberg
city: Cordoba
country: Argentina
facility: Hospital Italiano de Cordoba
city: Cordoba
country: Argentina
facility: Cent Priva Especiali Médicas Ambulatorias Inve Clin CEMAIC
city: Cordoba
country: Argentina
facility: Hospital Privado Centro Medico de Cordoba SA
city: San Juan
country: Argentina
facility: Centro Polivalente de Asistencia e Inv. Clinica CER-San Juan
city: Garran
country: Australia
facility: Canberra Hospital
state: Australian Capital Territory
city: Camperdown
country: Australia
facility: Royal Prince Alfred Hospital
state: New South Wales
city: Kogarah
country: Australia
facility: Combined Rheumatology Practice (CRP)
state: New South Wales
city: Maroochydore
country: Australia
facility: Coast Joint Care
state: Queensland
city: Camberwell
country: Australia
facility: Emeritus Research
state: Victoria
city: Fitzroy
country: Australia
facility: St Vincents Hospital Melbourne
state: Victoria
city: Graz
country: Austria
facility: Universitätsklinikum Graz
state: Steiermark
city: Wien
country: Austria
facility: Rheuma Zentrum Favoriten GmbH
city: Bruxelles
country: Belgium
facility: Cliniques Universitaires Saint-Luc
state: Brussel
city: Gent
country: Belgium
facility: Universitair Ziekenhuis Gent
state: Oost-Vlaanderen
city: Merksem
country: Belgium
facility: ZNA Jan Palfijn
state: Vlaams Gewest
city: Genk
country: Belgium
facility: Reuma Clinic, Locatie Jaarbeurslaan
city: Mons
country: Belgium
facility: CHU Ambroise Pare
city: São Paulo
country: Brazil
facility: CPCLIN
state: SP
city: São Paulo
country: Brazil
facility: CEPIC - Centro Paulista de Investigação Clínica
state: SP
city: Sao Paulo
country: Brazil
facility: Associacao de Assistencia a Crianca Deficiente (AACD)
state: São Paulo
city: Edmonton
country: Canada
facility: Rheumatology Research Associates Group
state: Alberta
city: Kelowna
country: Canada
facility: The Medical Arts Health Research Group
state: British Columbia
city: Victoria
country: Canada
facility: PerCuro Clinical Research Ltd.
state: British Columbia
city: Winnipeg
country: Canada
facility: Manitoba Clinic Medical Corporation
state: Manitoba
city: Kitchener
country: Canada
facility: KW Musculoskeletal Research Inc
state: Ontario
city: Ottawa
country: Canada
facility: The Ottawa Hospital
state: Ontario
city: St. Catherines
country: Canada
facility: Niagara Peninsula Arthritis Centre, Inc.
state: Ontario
city: Toronto
country: Canada
facility: UHN-Toronto Western Hospital
state: Ontario
city: Toronto
country: Canada
facility: Mount Sinai Hospital
state: Ontario
city: Quebec City
country: Canada
facility: Center de Recherche St Louis
state: Quebec
city: Trois-Rivieres
country: Canada
facility: Centre de Recherche Musculo-Squelettique
state: Quebec
city: Saskatoon
country: Canada
facility: Saskatoon Osteoporosis Centre
state: Saskatchewan
city: Bengbu
country: China
facility: Afflilated Hospital of Bengbu Medical College
state: Anhui
city: Hefei
country: China
facility: Anhui Provincial Hospital
state: Anhui
city: Hefei
country: China
facility: The First Affiliate Hospital of AnHui Medical University
state: Anhui
city: Beijing
country: China
facility: Peking University People's Hospital
state: Beijing
city: Guangzhou
country: China
facility: Guangdong Provincial People's Hospital
state: Guangdong
city: Shantou
country: China
facility: 1st Hospital affiliated to Medical College of Shantou Univer
state: Guangzhou
city: Changsha
country: China
facility: Xiangya Hospital, Central South University
state: Hunan
city: Changsha
country: China
facility: The Second Xiangya Hospital of Central South University
state: Hunan
city: ZhuZhou
country: China
facility: ZhuZhou Central Hospital
state: Hunan
city: Yancheng
country: China
facility: YanCheng First People's Hospital
state: Jiangsu
city: Pingxiang
country: China
facility: Pingxiang People's Hospital
state: Jiangxi
city: Jinan
country: China
facility: Qilu Hospital of Shandong University
state: Shandong
city: Shanghai
country: China
facility: Zhongshan Hospital, Fudan University
state: Shanghai
city: Cheng Du
country: China
facility: West China Hospital Sichuan University
state: Sichuan
city: Kunming
country: China
facility: First Affiliated Hospital of Kunming Medical University
state: Yunnan
city: Ningbo
country: China
facility: Ningbo First Hospital
state: Zhejiang
city: Beijing
country: China
facility: China-Japan Friendship Hospital
city: Shanghai
country: China
facility: Shanghai Guanghua Hospital
city: Osijek
country: Croatia
facility: KBC Osijek
city: Zagreb
country: Croatia
facility: Klinicka bolnica Sveti Duh
city: Zagreb
country: Croatia
facility: Poliklinika K-centar
city: Praha 2
country: Czechia
facility: Revmatologicky ustav
state: Praha, Hlavní Mešto
city: Brno
country: Czechia
facility: Revmaclinic, s.r.o
city: Bruntal
country: Czechia
facility: Revmatologicka ambulance
city: Hustopece
country: Czechia
facility: ELIMATES BRNO s.r.o. Revmatologicka ambulance
city: Ostrava
country: Czechia
facility: Vesalion s.r.o.
city: Ostrava
country: Czechia
facility: Artroscan, s.r.o.
city: Pardubice
country: Czechia
facility: ARTHROHELP s.r.o.
city: Uherske Hradiste
country: Czechia
facility: Medical Plus
city: Zlin
country: Czechia
facility: PV Medical Services s.r.o.
city: Frederiksberg
country: Denmark
facility: Frederiksberg Hospital
state: Hovedstaden
city: Glostrup
country: Denmark
facility: Copenhagen University Hospital
state: Hovedstaden
city: Odense C
country: Denmark
facility: Odense Universitetshospital
state: Syd
city: Limoges CEDEX
country: France
facility: CHRU de Limoges Hopital Dupuytren
state: Haute-Vienne
city: Cahors CEDEX 9
country: France
facility: Centre Hospitalier Jean Rougier
city: Chambray-lès-Tours
country: France
facility: Hôpital Trousseau, CHRU de Tours
city: Montpellier Cedex 5
country: France
facility: Hôpital Arnaud de Villeneuve - CHU Montpellier
city: Nantes Cedex 1
country: France
facility: Centre Hospitalier Universitaire de Nantes - L' Hopital l'hôtel-Dieu
city: Orleans CEDEX 2
country: France
facility: Nouvel Hôpital Orléans La Source
city: Paris CEDEX 13
country: France
facility: Hopital de la Pitie Salpetriere
city: Paris CEDEX 14
country: France
facility: Hopital Cochin
city: Poitiers
country: France
facility: CHU la Miletrie
city: Rennes CEDEX 2
country: France
facility: CHU Rennes/Hopital Sud
city: Thionville
country: France
facility: Hopital Bel Air
city: Heidelberg
country: Germany
facility: Universitätsklinikum Heidelberg
state: Baden-Württemberg
city: Bayreuth
country: Germany
facility: Internistisch-rheumatologische Praxisgemeinschaft Bayreuth
state: Bayern
city: München
country: Germany
facility: Klinikum der Universität München
state: Bayern
city: Würzburg
country: Germany
facility: Universitätsklinikum Würzburg A. ö. R.
state: Bayern
city: Köln
country: Germany
facility: Universitätsklinikum Köln
state: Nordrhein-Westfalen
city: Gommern
country: Germany
facility: Immunologisches Zentrum Vogelsang-Gommern GmbH
state: Sachsen-Anhalt
city: Dresden
country: Germany
facility: Städtisches Klinikum Dresden-Friedrichstadt
state: Sachsen
city: Berlin
country: Germany
facility: Charité Campus Virchow-Klinikum
city: Hamburg
country: Germany
facility: Schön Klinik Hamburg Eilbek
city: Athens
country: Greece
facility: Hippokration Hospital of Athens
state: Attiki
city: Kifissia
country: Greece
facility: General Hospital of Attica KAT
state: Attiki
city: Heraklion
country: Greece
facility: University General Hospital of Heraklion
state: Crete
city: Larissa
country: Greece
facility: University General Hospital of Larissa
city: Kiskunhalas
country: Hungary
facility: Kiskunhalasi Semmelweis Korhaz
state: Bacs-Kiskun
city: Bekescsaba
country: Hungary
facility: Dr. Rethy Pal Korhaz es Rendelointezet
state: Bekes
city: Szekesfehervar
country: Hungary
facility: Fejer Megyei Szent Gyorgy Egyetemi Oktato Korhaz
state: Fejer
city: Budapest
country: Hungary
facility: Revita Clinic
state: Pest
city: Nyiregyhaza
country: Hungary
facility: Szabolcs-Szatmar-Bereg M-i Korhazak es Egyetemi Oktatokorhaz
state: Szabolcs-Szatmar-Bereg
city: Budapest
country: Hungary
facility: Orszagos Reumatologiai es Fizioterapias Intezet
city: Veszprem
country: Hungary
facility: Csolnoky Ferenc Korhaz
city: Hyderabad
country: India
facility: Sumana Hospital
state: Andhra Pradesh
city: New Delhi
country: India
facility: Sir Ganga Ram Hospital
state: Delhi
city: New Delhi
country: India
facility: Indraprastha Apollo Hospital
state: Delhi
city: Ahmedabad
country: India
facility: Shalby Hospital
state: Gujarat
city: Gurgaon
country: India
facility: Medanta-The Medicity
state: Haryana
city: Attavar, Mangalore
country: India
facility: Manipal Centre for Clinical Research (MCCR)
state: Karnataka
city: Bangalore
country: India
facility: St. John Medical College & Hospital
state: Karnataka
city: Bangalore
country: India
facility: M S Ramaiah Medical College Hospital
state: Karnataka
city: Belgaum
country: India
facility: KLES Prabhakar Kore Hospital and Medical Research Centre
state: Karnataka
city: Mumbai
country: India
facility: Kokilaben Dhirubhai Ambani Hospital &Medical Research Inst.
state: Maharashtra
city: Jaipur
country: India
facility: Shri Nidan Hospital & Hope Fertility Centre
state: Rajasthan
city: Hyderabad
country: India
facility: Care Hospital
state: Telangana
city: Secunderabad
country: India
facility: Krishna Institute of Medical Sciences Ltd.
state: Telengana
city: Lucknow
country: India
facility: CSM Medical University
state: Uttar Pradesh
city: Kolkata
country: India
facility: IPGMER and SSKM Hospital
state: West Bengal
city: Kolkata
country: India
facility: Apollo Gleneagles Hospitals Kolkata
state: West Bengal
city: Ashkelon
country: Israel
facility: Barzilai Medical Center
state: HaDarom
city: Haifa
country: Israel
facility: Bnai Zion Medical Center
city: Haifa
country: Israel
facility: Rambam Health Care Campus
city: Jerusalem
country: Israel
facility: Hadassah Medical Center
city: Kfar Saba
country: Israel
facility: Meir Medical Center
city: Petah Tiqva
country: Israel
facility: Rabin Medical Center
city: Tel Aviv
country: Israel
facility: Tel Aviv Sourasky Medical Center
city: Zerifin
country: Israel
facility: Assaf Harofeh Medical Center
city: Haifa
country: Israel
facility: Carmel Hospital
state: Ḥeifā
city: Firenze
country: Italy
facility: Azienda Ospedaliera Universitaria Careggi
city: Milano
country: Italy
facility: Ospedale Luigi Sacco
city: Pisa
country: Italy
facility: Stabilimento Ospedaliero Santa Chiara
city: Roma
country: Italy
facility: Polic.Umberto I -Univ. La Sapienza
city: Torino
country: Italy
facility: Ospedale San Giovanni Bosco
city: Verona
country: Italy
facility: Ospedale Policlinico Giambattista Rossi, Borgo Roma
city: Nagoya
country: Japan
facility: Chubu-Rosai Hospital
state: Aichi
city: Nagoya
country: Japan
facility: Nagoya Medical Center
state: Aichi
city: Nagoya
country: Japan
facility: Nagoya University Hospital
state: Aichi
city: Chuo-ku
country: Japan
facility: National Chiba-East-Hospital
state: Chiba
city: Matsudo
country: Japan
facility: Matsudo City Hospital
state: Chiba
city: Narashino
country: Japan
facility: Chibaken Saiseikai Narashino Hospital
state: Chiba
city: Yotsukaido
country: Japan
facility: Shimoshizu National Hospital
state: Chiba
city: Hakata-ku
country: Japan
facility: PS Clinic
state: Fukuoka
city: Iizuka
country: Japan
facility: Aso Iizuka Hospital
state: Fukuoka
city: Kitakyushu
country: Japan
facility: University of Occupational and Enviromental Health
state: Fukuoka
city: Asahikawa
country: Japan
facility: National Hospital Organization Asahikawa Medical Center
state: Hokkaido
city: Asahikawa
country: Japan
facility: Katayama Clinic
state: Hokkaido
city: Sapporo
country: Japan
facility: Sagawa Akira Rheumatology Clinic
state: Hokkaido
city: Sapporo
country: Japan
facility: NTT East Japan Sapporo Hospital
state: Hokkaido
city: Sapporo
country: Japan
facility: Hokkaido University Hospital
state: Hokkaido
city: Sapporo
country: Japan
facility: Hokkaido Medical Center for Rheumatic Diseases
state: Hokkaido
city: Kato
country: Japan
facility: Matsubara Mayflower Hospital
state: Hyogo
city: Takarazuka
country: Japan
facility: Takarazuka City Hospital
state: Hyogo
city: Hitachi
country: Japan
facility: Oasis Clinic
state: Ibaragi
city: Tsukuba
country: Japan
facility: Tsukuba University Hospital
state: Ibaraki
city: Morioka
country: Japan
facility: Yoshida Orthopaedic and Rheumatic Clinic
state: Iwate
city: Morioka
country: Japan
facility: Komagamine Orthopedic and Rheumatology Clinic
state: Iwate
city: Kita-gun
country: Japan
facility: Kagawa University Hospital
state: Kagawa
city: Kirishima
country: Japan
facility: Yoshitama Clinic Rheumatology & Internal Medicine
state: Kagoshima
city: Isehara
country: Japan
facility: Tokai University Hospital
state: Kanagawa
city: Kawasaki
country: Japan
facility: St Marianna University School of Medicine Hospital
state: Kanagawa
city: Yokohama-City
country: Japan
facility: Tsuzuki Azuma Clinic: Primary care and Rheumatology
state: Kanagawa
city: Yokohama
country: Japan
facility: Yokohama Rosai Hospital
state: Kanagawa
city: Yokohama
country: Japan
facility: Yokohama City University Hospital
state: Kanagawa
city: Yokohama
country: Japan
facility: Yokohama Minami Kyosai Hospital
state: Kanagawa
city: Koshi
country: Japan
facility: Kumamoto Saishun Medical Center
state: Kumamoto
city: Yokkaichi
country: Japan
facility: Yokkaichi Hazu Medical Center
state: Mie
city: Omura
country: Japan
facility: National Nagasaki Medical Center
state: Nagasaki
city: Sasebo
country: Japan
facility: Sasebo Chuo Hospital
state: Nagasaki
city: Nagaoka
country: Japan
facility: Nagaoka Red Cross Hospital
state: Niigata
city: Shibata
country: Japan
facility: Niigata Rheumatic Center
state: Niigata
city: Setouchi
country: Japan
facility: Osafune Clinic
state: Okayama
city: Tomigusuku
country: Japan
facility: Tomishiro Central Hospital
state: Okinawa
city: Ureshino
country: Japan
facility: NHO Ureshino Medical Center
state: Saga
city: Kawagoe
country: Japan
facility: Saitama Medical Center
state: Saitama
city: Kawaguchi
country: Japan
facility: Kaneko Clinic
state: Saitama
city: Sayama
country: Japan
facility: Azuma Rheumatology Clinic
state: Saitama
city: Tokorozawa
country: Japan
facility: Hirose Clinic
state: Saitama
city: Hamamatsu
country: Japan
facility: Seirei Hamamatsu General Hospital
state: Shizuoka
city: Shimotsuke
country: Japan
facility: Jichi Medical University Hospital
state: Tochigi
city: Arakawa-ku
country: Japan
facility: Tokyo Women's Medical University East Medical Center
state: Tokyo
city: Chuo-Ku
country: Japan
facility: St. Lukes International Hospital
state: Tokyo
city: Hachioji
country: Japan
facility: Fujimori Clinic
state: Tokyo
city: Itabashi-ku
country: Japan
facility: Nihon University Itabashi Hospital
state: Tokyo
city: Meguro-Ku
country: Japan
facility: National Tokyo Medical Center
state: Tokyo
city: Mitaka
country: Japan
facility: Kyorin University Hospital
state: Tokyo
city: Shinjuku-Ku
country: Japan
facility: Keio University Hospital
state: Tokyo
city: Takaoka
country: Japan
facility: Takaoka Rheumatic Orthopedic CL
state: Toyama
city: Shunan
country: Japan
facility: Miyasato Clinic
state: Yamaguchi
city: Fukuoka
country: Japan
facility: National Hospital Organization Kyushu Medical Center
city: Fukuoka
country: Japan
facility: Kondo Clinic for Rheumatism and Orthopaedics
city: Fukuoka
country: Japan
facility: Medical Co. LTA Fukuoka Mirai Hospital
city: Fukuoka
country: Japan
facility: Shono Rheumatism Clinic
city: Hiroshima
country: Japan
facility: Hiroshima Rheumatology Clinic
city: Hiroshima
country: Japan
facility: Hiroshima Clinic
city: Kagoshima
country: Japan
facility: Kagoshima Red Cross Hospital
city: Kumamoto
country: Japan
facility: Kumamoto Rheumatology Clinic
city: Kumamoto
country: Japan
facility: Kumamoto Orthopedic Hospital
city: Kumamoto
country: Japan
facility: Kumamoto Shinto General hospital
city: Nagano
country: Japan
facility: Nagano Red Cross Hospital
city: Nagasaki
country: Japan
facility: Nagasaki Medical Hospital of Rheumatology
city: Nagasaki
country: Japan
facility: The Japanese Red Cross Nagasaki Genbaku Hospital
city: Oita
country: Japan
facility: Oribe Clinic Rheumatism and Medicine
city: Okayama
country: Japan
facility: Okayama Saiseikai General Hospital Outpatient Center
city: Okayama
country: Japan
facility: Okayama University Hospital
city: Okayama
country: Japan
facility: Japanese Red Cross Okayama Hospital
city: Osaka
country: Japan
facility: Yokota Clinic for Rheumatology
city: Shizuoka
country: Japan
facility: Shizuoka Rheumatism orthopedic Rehabilitation Hospital
city: Shizuoka
country: Japan
facility: JA-Shizuoka Shizuoka-Kosei General Hospital
city: Suwon
country: Korea, Republic of
facility: Ajou University Hospital
state: Gyeonggi-do
city: Dae Jeon
country: Korea, Republic of
facility: Chungnam National University Hospital
state: Korea
city: Daegu
country: Korea, Republic of
facility: Kyung Pook National University Hospital
state: Korea
city: Daegu
country: Korea, Republic of
facility: Daegu Catholic University Medical Center
state: Korea
city: Daejeon
country: Korea, Republic of
facility: Chungnam National University Hospital
state: Korea
city: Gwangju
country: Korea, Republic of
facility: Chonnam National University Hospital
state: Korea
city: Incheon
country: Korea, Republic of
facility: Gachon University Gil Medical Center
state: Korea
city: Incheon
country: Korea, Republic of
facility: Inha University Hospital
state: Korea
city: Seoul
country: Korea, Republic of
facility: Kyung Hee University Hospital
state: Korea
city: Seoul
country: Korea, Republic of
facility: Seoul National University Hospital
state: Korea
city: Seoul
country: Korea, Republic of
facility: Hanyang University Medical Center
state: Korea
city: Seoul
country: Korea, Republic of
facility: Kyunghee University Hospital at Gangdong
state: Korea
city: Seoul
country: Korea, Republic of
facility: Asan Medical Center
state: Korea
city: Seoul
country: Korea, Republic of
facility: Seoul St. Mary's Hospital
state: Korea
city: Seoul
country: Korea, Republic of
facility: Seoul Municipal Boramae Hospital
state: Korea
city: Seoul
country: Korea, Republic of
facility: Catholic University of Korea Yeouido St. Mary's Hospital
state: Korea
city: Seoul
country: Korea, Republic of
facility: Konkuk University Medical Center
state: Seoul-teukbyeolsi [Seoul]
city: Liepaja
country: Latvia
facility: Rheumatology Practice in Jaunliepaja Primary Health Care Cen
city: Riga
country: Latvia
facility: Pauls Stradins Kliniska Universitates Slimnica
city: Valmiera
country: Latvia
facility: Dr. Sarmite Saleniece
city: Kaunas
country: Lithuania
facility: Dr. Kildos Klinika
city: Klaipeda
country: Lithuania
facility: Klaipedos Universitetine Ligonine
city: Siauliai
country: Lithuania
facility: Respublikine Siauliu Ligonine
city: Mexicali
country: Mexico
facility: Ctro Inv en Artritis y Osteoporosis SC
state: Baja California
city: Tijuana
country: Mexico
facility: Centro de Investigacion del Noroeste
state: Baja California
city: Mexico City
country: Mexico
facility: Mexico Centre for Clinical Research SA de CV
state: Distrito Federal
city: Mexico City
country: Mexico
facility: RM Pharma Specialists S.A. de C.V.
state: Distrito Federal
city: Mexico City
country: Mexico
facility: Hospital de Jesus I.A.P.
state: Distrito Federal
city: Mexico City
country: Mexico
facility: Comite Mexicano para la Prevencion de la Osteoporosis A.C.
state: Distrito Federal
city: Mexico City
country: Mexico
facility: Mentrials S.A. de C.V
state: Distrito Federal
city: Guadalajara
country: Mexico
facility: Centro Integral en Reumatologia SA de CV
state: Jalisco
city: Guadalajara
country: Mexico
facility: Unidad de Investigacion en Enfermedades Cronico Degenerative
state: Jalisco
city: Guadalajara
country: Mexico
facility: Clinica de Investigacion en Reumatologia y Obesidad S. C.
state: Jalisco
city: Guadalajara
country: Mexico
facility: Private Service
state: Jalisco
city: Guadalajara
country: Mexico
facility: Centro de Estudios de Investigacion Basica y Clinica, S.C.
state: Jalisco
city: Monterrey
country: Mexico
facility: Hospital Universitario de Monterrey
state: Nuevo Leon
city: Merida
country: Mexico
facility: Centro Medico de las Americas
state: Yucatan
city: Merida
country: Mexico
facility: Medical Care and Research, S.A. de C.V.
state: Yucatan
city: San Luis Potosi
country: Mexico
facility: Centro de Alta Especialidad Reumatologia e Inv Potosi, S.C.
city: Almelo
country: Netherlands
facility: Ziekenhuisgroep Twente, Almelo
city: Gdansk
country: Poland
facility: Centrum Badan Klinicznych PI-House sp. z o.o.
state: Pomorskie
city: Bydgoszcz
country: Poland
facility: Szpital Uniwersytecki Nr 2 w Bydgoszczy, Klinika Reumatologii i Ukladowych Chorob Tkanki Lacznej
city: Elblag
country: Poland
facility: Ambulatorium Barbara Bazela
city: Katowice
country: Poland
facility: Centrum Medyczne Pratia Katowice
city: Lodz
country: Poland
facility: Centrum Terapii Wspolczesnej J. M. Jasnorzewska Spolka Komandytowo-Akcyjna
city: Nadarzyn
country: Poland
facility: NZOZ Lecznica MAK-MED s.c.
city: Warszawa
country: Poland
facility: REUMATIKA - Centrum Reumatologii
city: Warszawa
country: Poland
facility: Centrum Medyczne AMED
city: Almada
country: Portugal
facility: Hospital Garcia da Orta
city: Lisbon
country: Portugal
facility: Instituto Portugues de Reumatologia
city: Ponte de Lima
country: Portugal
facility: Hospital do Conde de Bertiandos
city: Porto
country: Portugal
facility: Hospital Geral de Santo Antonio
city: Porto
country: Portugal
facility: Hospital de Sao Joao E.P.E.
city: Carolina
country: Puerto Rico
facility: Ramon L. Ortega Colon
city: Ponce
country: Puerto Rico
facility: Ponce School of Medicine CAIMED Center
city: San Juan
country: Puerto Rico
facility: Latin Clinical Trial Center
city: San Juan
country: Puerto Rico
facility: Mindful Medical Research
city: San Juan
country: Puerto Rico
facility: Barbara Diaz Hernandez
city: Tg.Mures
country: Romania
facility: Spital Clinic Judetean de Urgenta Tg.Mures
state: Mures
city: Bucuresti
country: Romania
facility: SC DUO Medical S.R.L Rheumatology
city: Bucuresti
country: Romania
facility: Spitalul Clinic Sf Maria Bucuresti
city: Bucuresti
country: Romania
facility: Spitalul Clinic "Dr. Ioan Cantacuzino"
city: Constanta
country: Romania
facility: Spitalul Clinic Judetean de Urgenta Sf.Apostol Andrei Constanta
city: Iasi
country: Romania
facility: Spitalul Clinic de Recuperare Iasi
city: Saint-Petersburg
country: Russian Federation
facility: Gbuz Lokb
state: Leningradskaya Oblast'
city: Ul'yanovsk
country: Russian Federation
facility: GUZ UOKB
state: Ul'yanovskaya Oblast
city: Korolev
country: Russian Federation
facility: Family Clinic No 4
city: Moscow
country: Russian Federation
facility: V.A. Nasonova Research Institute of Rheumatology
city: Moscow
country: Russian Federation
facility: City Clinical Hospital 1 named after N.I. Pirogov
city: Moscow
country: Russian Federation
facility: First Moscow State Medical University
city: Ryazan
country: Russian Federation
facility: Ryazan Regional Clinincal Cardiology Dispensary
city: Saratov
country: Russian Federation
facility: Saratov Regional Clinical Hospital
city: St. Petersburg
country: Russian Federation
facility: Clinical Rheumatology Hospital # 25
city: Yaroslavl
country: Russian Federation
facility: Clinical Emergency Hospital N.V.Solovyov
city: Bratislava
country: Slovakia
facility: Nestatna reumatologicka ambulancia
city: Bratislava
country: Slovakia
facility: ROMJAN s.r.o.
city: Partizanske
country: Slovakia
facility: Reumacentrum s.r.o.
city: Spisska Nova Ves
country: Slovakia
facility: REUMED s.r.o.
city: Topolcany
country: Slovakia
facility: LERAM s.r.o.
city: Ljubljana
country: Slovenia
facility: Bolnisnica Dr. P. Drzaja UKCLJ
city: Port Elizabeth
country: South Africa
facility: Netcare Greenacres Hospital
state: Eastern Cape
city: Durban
country: South Africa
facility: Saint Augustine's Hospital
state: KZ-Natal
city: Durban
country: South Africa
facility: Precise Clinical Solutions (Pty) Ltd
state: KZ-Natal
city: Cape Town
country: South Africa
facility: Arthritis Clinical Trial Centre
state: Western Cape
city: Somerset West
country: South Africa
facility: Somerset West Trial Centre
state: Western Cape
city: Stellenbosch
country: South Africa
facility: Winelands Medical Research Centre
state: Western Cape
city: La Vila Joiosa
country: Spain
facility: Hospital Marina Baixa
state: Alicante
city: Sevilla
country: Spain
facility: Hospital Quiron Infanta Luisa
state: Andalucía
city: Sabadell
country: Spain
facility: Corporacion Sanitaria Parc Tauli
state: Barcelona
city: Santander
country: Spain
facility: Hospital Universitario Marques De Valdecilla
state: Cantabria
city: Getafe
country: Spain
facility: Hospital Universitario Getafe
state: Madrid
city: Bilbao
country: Spain
facility: Hospital De Basurto
state: Vizcaya
city: Barcelona
country: Spain
facility: Hospital de la Santa Creu i Sant Pau
city: Barcelona
country: Spain
facility: Hospital Clinic I Provincial
city: Sevilla
country: Spain
facility: Hospital Universitario Virgen Macarena
city: Valencia
country: Spain
facility: Hospital Universitario La Fe de Valencia
city: Göteborg
country: Sweden
facility: Sahlgrenska Universitetssjukhuset
state: Gothenburg
city: Malmo
country: Sweden
facility: Reumatologiska Kliniken Skånes universitetssjukhus Malmö
city: Lausanne
country: Switzerland
facility: CHUV Centre Hospitalier Universitaire Vaudois
state: Vaud
city: Fribourg
country: Switzerland
facility: HFR Fribourg - Hôpital Cantonal
city: Zürich
country: Switzerland
facility: Universitätsspital Zürich
city: Kaohsiung City
country: Taiwan
facility: Chang Gung Memorial Hospital - Kaohsiung Branch
city: Neihu Taipei
country: Taiwan
facility: Tri-Service General Hospital
city: Taichung City
country: Taiwan
facility: Chung Shan Medical University Hospital
city: Taichung City
country: Taiwan
facility: China Medical University Hospital
city: Taipei City
country: Taiwan
facility: National Taiwan University Hospital
city: Taipei City
country: Taiwan
facility: MacKay Memorial Hospital
city: Taipei City
country: Taiwan
facility: Cathay General Hospital
city: Taipei City
country: Taiwan
facility: Taipei Veterans General Hospital
city: Yongkang City
country: Taiwan
facility: Chi-Mei Medical Center
city: Edirne
country: Turkey
facility: Trakya University
city: Cambridge
country: United Kingdom
facility: Addenbrookes Hospital
state: Cambridgeshire
city: Basingstoke
country: United Kingdom
facility: Basingstoke and North Hampshire Hospital
state: Hampshire
city: Southampton
country: United Kingdom
facility: Southampton General Hospital
state: Hants
city: London
country: United Kingdom
facility: Whipps Cross University Hospital
state: Surrey
city: London
country: United Kingdom
facility: Guy's Hospital
state: Surrey
city: Newcastle upon Tyne
country: United Kingdom
facility: Northumbria Healthcare NHS Foundation Trust
state: Tyneside
city: Bradford
country: United Kingdom
facility: St Lukes Hospital
state: West Yorkshire
Study officials:
affiliation: Eli Lilly and Company
name: Call 1-877-CTLILLY (1-877-285-4559) or 1-317-615-4559 Mon - Fri 9 AM - 5 PM Eastern time (UTC/GMT - 5 hours, EST)
role: STUDY_DIRECTOR
References:
citation: Taylor PC, Takeuchi T, Burmester GR, Durez P, Smolen JS, Deberdt W, Issa M, Terres JR, Bello N, Winthrop KL. Safety of baricitinib for the treatment of rheumatoid arthritis over a median of 4.6 and up to 9.3 years of treatment: final results from long-term extension study and integrated database. Ann Rheum Dis. 2022 Mar;81(3):335-343. doi: 10.1136/annrheumdis-2021-221276. Epub 2021 Oct 27.
citation: Wells AF, Jia B, Xie L, Valenzuela GJ, Keystone EC, Li Z, Quebe AK, Griffing K, Otawa S, Haraoui B. Efficacy of Long-Term Treatment with Once-Daily Baricitinib 2 mg in Patients with Active Rheumatoid Arthritis: Post Hoc Analysis of Two 24-Week, Phase III, Randomized, Controlled Studies and One Long-Term Extension Study. Rheumatol Ther. 2021 Jun;8(2):987-1001. doi: 10.1007/s40744-021-00317-9. Epub 2021 May 24.
citation: Fleischmann R, Takeuchi T, Schiff M, Schlichting D, Xie L, Issa M, Stoykov I, Lisse J, Martinez-Osuna P, Rooney T, Zerbini CAF. Efficacy and Safety of Long-Term Baricitinib With and Without Methotrexate for the Treatment of Rheumatoid Arthritis: Experience With Baricitinib Monotherapy Continuation or After Switching From Methotrexate Monotherapy or Baricitinib Plus Methotrexate. Arthritis Care Res (Hoboken). 2020 Aug;72(8):1112-1121. doi: 10.1002/acr.24007.
citation: Tanaka Y, Fautrel B, Keystone EC, Ortmann RA, Xie L, Zhu B, Issa M, Patel H, Gaich CL, de Bono S, Rooney TP, Taylor PC. Clinical outcomes in patients switched from adalimumab to baricitinib due to non-response and/or study design: phase III data in patients with rheumatoid arthritis. Ann Rheum Dis. 2019 Jul;78(7):890-898. doi: 10.1136/annrheumdis-2018-214529. Epub 2019 Apr 30.
citation: Winthrop KL, Bingham CO 3rd, Komocsar WJ, Bradley J, Issa M, Klar R, Kartman CE. Evaluation of pneumococcal and tetanus vaccine responses in patients with rheumatoid arthritis receiving baricitinib: results from a long-term extension trial substudy. Arthritis Res Ther. 2019 Apr 18;21(1):102. doi: 10.1186/s13075-019-1883-1.
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