Clinical trial NCT04951011: Different Treatment Options for Tubal Ectopic Pregnancy:- A Systmatic Review
Official title: Different Treatment Options for Tubal Ectopic Pregnancy:- A Systmatic Review
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Woman With Tubal Ectopic Pregnancy
Lead sponsor: Sohag University
Sponsor class: OTHER
First posted: 2021-07-06
Enrollment: 50
Sex: FEMALE
Minimum age (years): 15
Maximum age (years): 40
Standard ages: CHILD
ADULT
Observational model: CASE_CONTROL
Time perspective: CROSS_SECTIONAL
Sampling method: PROBABILITY_SAMPLE
Study population: Sample size: All articles fulfilling the inclusion criteria within the last five years.

Study tools: Primary data will be re-analyzed statistically and processed data to be compared. Secondary data will be analyzed for correlation between the type of anastomosis (hand sewing vs. staplers) and between measurements outcome (leakage and, stricture and fistula formation).

• Study procedure: The study will start by searching articles using the key words and then downloading papers that fulfill the inclusion criteria and excluding papers with exclusion criteria. These papers will be examined by the supervisors to make sure of finding the appropriate source of data and then I will start working with the statistical supervisor and put data on R-based software for meta-analysis and start conducting the study.

Brief summary: Ectopic pregnancy is an early pregnancy complication in which a fertilized ovum implant outside the uterine cavity. Implantation may occur anywhere along the reproductive tract with the most common implantation site being the fallopian tube. The incidence of ectopic pregnancy is 1% of pregnant women, and may seriously compromise women's health and future fertility.

Currently, ectopic pregnancy can be often diagnosed before the woman's condition has deteriorated, which has altered the former clinical picture of a lifethreatening disease into a more benign condition in frequently asymptomatic women.


Eligibility criteria: Inclusion criteria:

* RCTs and observational studies
* All types of ectopic pregnancies.
* All types of treatments and medications for ectopic pregnancies.
* The long-term survival of patients with or without complications.
* Successful pregnancy and birth.

Exclusion criteria:

* Articles of failed treatments of ectopic pregnancies.
* Articles with over all P value \> 0.05.
* Articles for which the full text is not available in English.

Primary outcomes:
measure: Abdominal and Transvaginal Ultrasound:
timeFrame: 6 Monthes
measure: S.bHCG:
timeFrame: 6 Monthes
measure: Diagnostic laparoscopy
timeFrame: 6 Monthes
Secondary outcomes:
Other outcomes:
Locations:
city: Akhmim
country: Egypt
facility: Sohag
Study officials:
References:
citation: Barnhart KT. Clinical practice. Ectopic pregnancy. N Engl J Med. 2009 Jul 23;361(4):379-87. doi: 10.1056/NEJMcp0810384. No abstract available.
citation: Bagshawe KD, Dent J, Newlands ES, Begent RH, Rustin GJ. The role of low-dose methotrexate and folinic acid in gestational trophoblastic tumours (GTT). Br J Obstet Gynaecol. 1989 Jul;96(7):795-802. doi: 10.1111/j.1471-0528.1989.tb03318.x.
citation: Elson J, Tailor A, Banerjee S, Salim R, Hillaby K, Jurkovic D. Expectant management of tubal ectopic pregnancy: prediction of successful outcome using decision tree analysis. Ultrasound Obstet Gynecol. 2004 Jun;23(6):552-6. doi: 10.1002/uog.1061.