Clinical trial NCT01874132: Study of the Long-term Effects of Exercise on Heath Indicators in Older People
Official title: A Randomised Longitudinal Study of Exercise Prescription for Older Adults: Mode and Intensity to Induce the Highest Cardiovascular Health-related Benefits
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Hypertension With Complications and Secondary Hypertension
Overweight and Obesity
Lipid Metabolism Disorders
Sarcopenia
Osteoporosis
Personal Satisfaction
Keywords: Exercise
Blood pressure
Lipids
Body composition
Fitness
Bone density
Quality of life
Lead sponsor: University of Trás-os-Montes and Alto Douro
Sponsor class: OTHER
First posted: 2013-06-10
Enrollment: 66
Sex: MALE
Minimum age (years): 65
Maximum age (years): 79
Standard ages: OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: PREVENTION

Brief summary: Cardiovascular diseases (CVD) represent the most frequent cause of death among the elderly population. Hypertension, unfavorable lipid profile, obesity and physical inactivity are among the main risk factors for CVD. In contrast, mortality from CVD is inversely related to levels of physical activity, and is lower in individuals who exercise and have higher functional fitness levels. Thus, the Centers for Disease Control and Prevention, the American College of Sports Medicine, and the American Heart Association have recommended 20-30 min of moderate-to-vigorous aerobic training for the elderly, preferably every day or at least 3 days a week in the case of vigorous exercise.The same organizations also suggest the inclusion of resistance training in order to improve functional fitness. Therefore, the purpose of this study was to compare different exercise modalities in long-term changes of CVD risk factors and physical fitness among older adults.


Eligibility criteria: Inclusion Criteria:

* Older adults living independently;
* medical approval.

Exclusion Criteria:

* Non-smokers;
* Non-morbidly obese;
* No history of severe hypertension;
* No history of falls;
* No orthopaedic, neurological, pulmonary, or cardiac problems.

Primary outcomes:
measure: Cardiovascular Disease Risk Factors
timeFrame: one year
Secondary outcomes:
measure: Risk of Falls
timeFrame: One year
Other outcomes:
measure: Quality of Life
timeFrame: One year
Locations:
city: Maia
country: Portugal
facility: Maia City Council facilities
Study officials:
affiliation: Research Center in Sport Sciences, Health Sciences and Human Development; University of Trás-os-Montes e Alto Douro
name: Nelson Sousa, PhD
role: PRINCIPAL_INVESTIGATOR
affiliation: Research Center in Physical Activity, Health and Leisure; Sport Faculty, University of Porto
name: José Oliveira, PhD
role: STUDY_DIRECTOR
affiliation: University of Trás-os-Montes and Alto Douro
name: Romeu Mendes, MD
role: STUDY_CHAIR
References:
citation: Sousa N, Mendes R, Oliveira J. Response to Drs. Safer and Safer. J Am Geriatr Soc. 2014 Mar;62(3):590-1. doi: 10.1111/jgs.12712. No abstract available.
citation: Sousa N, Mendes R, Abrantes C, Sampaio J, Oliveira J. Long-term effects of aerobic training versus combined aerobic and resistance training in modifying cardiovascular disease risk factors in healthy elderly men. Geriatr Gerontol Int. 2013 Oct;13(4):928-35. doi: 10.1111/ggi.12033. Epub 2013 Feb 26.
citation: Sousa N, Mendes R, Abrantes C, Sampaio J, Oliveira J. A randomized 9-month study of blood pressure and body fat responses to aerobic training versus combined aerobic and resistance training in older men. Exp Gerontol. 2013 Aug;48(8):727-33. doi: 10.1016/j.exger.2013.04.008. Epub 2013 Apr 26.
citation: Sousa N, Mendes R, Abrantes C, Sampaio J, Oliveira J. Is once-weekly resistance training enough to prevent sarcopenia? J Am Geriatr Soc. 2013 Aug;61(8):1423-4. doi: 10.1111/jgs.12387. No abstract available.
citation: Sousa N, Mendes R, Abrantes C, Sampaio J, Oliveira J. Effectiveness of combined exercise training to improve functional fitness in older adults: A randomized controlled trial. Geriatr Gerontol Int. 2014 Oct;14(4):892-8. doi: 10.1111/ggi.12188. Epub 2014 Apr 30.
citation: Sousa N, Mendes R, Abrantes C, Sampaio J, Oliveira J. A randomized study on lipids response to different exercise programs in overweight older men. Int J Sports Med. 2014 Dec;35(13):1106-11. doi: 10.1055/s-0034-1374639. Epub 2014 Jul 10.
citation: Sousa N, Mendes R, Silva A, Oliveira J. Combined exercise is more effective than aerobic exercise in the improvement of fall risk factors: a randomized controlled trial in community-dwelling older men. Clin Rehabil. 2017 Apr;31(4):478-486. doi: 10.1177/0269215516655857. Epub 2016 Jul 10.