Clinical trial NCT06589232: Threshold Dose Distribution for Pistachio Allergy
Official title: Threshold Dose Distribution for Pistachio Allergy in Children
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Allergy
Food Allergy
Lead sponsor: Central Hospital, Nancy, France
Sponsor class: OTHER
First posted: 2024-09-19
Enrollment: 50
Sex: ALL
Minimum age (years): 1
Maximum age (years): 18
Standard ages: CHILD
ADULT
Accepts healthy volunteers: yes
Observational model: COHORT
Time perspective: RETROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Patients under 18 years of age who had a positive pistachio challenge test between January 2021 and December 2023, in the pediatric allergology unit of the Nancy CHRU

Brief summary: The main objective of this study is to describe the distribution of reactogenic thresholds for pistachio. The secondary objectives are to 1) describe the clinical severity of allergic reactions to pistachio in an oral challenge test, 2) compare the reactogenic thresholds of pistachio and cashew nut on matched data and 3) evaluate predictive factors of a low reactogenic threshold

Detailed description: Nuts, including almonds, walnuts, cashews, pistachio and hazelnut, are among the food allergens most frequently involved in food allergies in children with an estimated prevalence. between 0.05 and 4.9%.

According to data from the Allergo-Vigilance Network, peanuts and the group of nuts, led by cashews, are alone responsible for 51.4% of food anaphylaxis in children.

The pistachio belongs to the same botanical family as the cashew nut (Anacardiumouest) and the mango (Mangifera indica): the anacardiaceae. Botanically, pistachio and cashew are closely related and can both be responsible for moderate to severe immediate allergic reactions. Furthermore, in a previous publication by the team, co-sensitization to pistachio was observed in 98% of children allergic to cashew nuts with only 34% confirmed allergic to pistachio.

In the case of allergy to both anacardiaceae, in a small number of patients, the investigators reported a reactogenic threshold for pistachio greater than or equal to that for cashew nuts.

To our knowledge, there is currently only one study that has evaluated the reactogenic threshold for pistachio, compared to other nuts.

Eligibility criteria: Inclusion Criteria:

* Patients under 18 years of age who had a positive pistachio challenge test between January 2021 and December 2023, in the pediatric allergology unit of the Nancy CHRU.

Exclusion Criteria:

* Patients who had a questionable oral pistachio provocation test.
* Patients who had a negative pistachio oral provocation test.

Primary outcomes:
measure: Threshold dose to pistachio
timeFrame: in the 4 hours of monitoring
Secondary outcomes:
measure: Threshold dose to cashew
timeFrame: in the 4 hours of monitoring
measure: Severity of the reaction during a positive pistachio oral provocation test
timeFrame: in the 4 hours of monitoring
Other outcomes:
Locations:
city: Vandœuvre-les-Nancy
country: France
facility: Centre Hospitalo-Universitaire de Nancy
Study officials:
affiliation: Centre hospitalo-universitaire de Nancy
name: Amandine DIVARET-CHAUVEAU
role: PRINCIPAL_INVESTIGATOR
References: