Clinical trial NCT00607815: A Comparison of Cognitive Processing Therapy (CPT) Versus Present Centered Therapy (PCT) for Veterans
Official title: A Comparison of CPT vs PCT for Veterans
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: PTSD
Keywords: PTSD
OEF/OIF
Combat
Treatment
CPT
PCT
Cognitive
Lead sponsor: VA Office of Research and Development
Sponsor class: FED
First posted: 2008-02-06
Enrollment: 79
Sex: MALE
Minimum age (years): 18
Maximum age (years): 75
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The purpose of this study is to compare the effectiveness of Cognitive Processing Therapy (CPT) versus Present Centered Therapy (PCT) for male OEF/OIF Veterans with combat related PTSD.

Detailed description: The purpose of this study is to compare the effectiveness of Cognitive Processing Therapy (CPT) versus Present Centered Therapy (PCT) for male OEF/OIF Veterans with combat related PTSD.

CPT has been shown to be effective in treating trauma survivors in several treatment outcome studies, but utility with Veterans has only been examined with male Veterans in one small pilot study. In addition CPT has never been compared to a treatment as usual or supportive psychotherapy condition to control for the specific and nonspecific elements of treatment. Although Cognitive Processing Therapy is one of the main treatment modalities at several VA's, including Cincinnati, it has never been compared to PCT, nor has it been used in a large, randomized study of male OEF/OIF Veterans. It is hypothesized that individual receiving CPT will show a larger reduction in posttraumatic stress disorder and related symptoms than those individuals receiving PCT.

All male OEF/OIF Veterans will be screened for their appropriateness for the study by phone screen and then by an assessment technician. The Veteran will be assessed at pre, post, 3-month, and 1-year follow-up. The assessment technicians will be blind to the participant's condition. CPT is a 12 week long individual psychotherapy treatment shown to be effective at reducing PTSD and related symptoms for survivors of various types of traumas, including combat. PCT is a supportive counseling treatment that has been utilized as an alternative to waitlist control in VA cooperative studies of PTSD.

Eligibility criteria: Inclusion Criteria:

* PTSD;
* memory of the trauma;
* able to read/write;
* must be stable on medication for 3 months

Exclusion Criteria:

* Psychosis;
* suicidal/homicidal intent;
* alcohol/substance dependence;
* no memory of the trauma

Primary outcomes:
measure: Clinician Administered PTSD Scale
timeFrame: Post-treatment, at 3 months and 1 year
measure: PTSD Checklist (PCL)
timeFrame: post-treatment, at 3 months and 1 year
Secondary outcomes:
measure: Beck Depression Inventory - II (BDI-II)
timeFrame: post-treatment, at 3 months and 1 year
measure: State-Trait Anger Scale (STAXI)
timeFrame: post-treatment, at 3 months and 1 year
measure: State-Trait Anxiety Scale
timeFrame: post-treatment, at 3 months and 1 year
Other outcomes:
Locations:
city: Cincinnati
country: United States
facility: Cincinnati VA Medical Center, Cincinnati, OH
state: Ohio
Study officials:
affiliation: Cincinnati VA Medical Center, Cincinnati, OH
name: Kathleen M Chard, PhD
role: PRINCIPAL_INVESTIGATOR
References: