Clinical trial NCT04643444: Police COVID-19 Serosurvey
Official title: Police Officer COVID-19 Seroprevalence Survey in the Canton of Bern, Switzerland
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: SARS-CoV-2 Infection
Volunteers
Healthy
Keywords: COVID-19
SARS-COV-2
Antibodies
Seroprevalence
Lead sponsor: University of Bern
Sponsor class: OTHER
Collaborators: name: Interregionale Blutspende SRK Bern
First posted: 2020-11-25
Enrollment: 1000
Sex: ALL
Minimum age (years): 18
Maximum age (years): 65
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Employees of the cantonal police of Bern, Switzerland

Brief summary: The investigators aim to determine the immune status of the employees of the cantonal police of Bern against SARS-CoV-2 over a period of 1 year, and to investigate the risk profile of the study participants and their risk of SARS-CoV-2 exposure in their working and private environments, as well as to evaluate the use of personal protective equipment at potential exposure instances.

Detailed description: i) To determine the extent of infection with seroprevalence data in the special population of police officers of the canton Bern.

ii) To determine risk factors for infection by comparing the proportion of seropositivity (infected versus noninfected individuals). The investigators hypothesize that police officers with fieldwork activity will have a higher seroprevalence than will office and administration personnel. The investigators hypothesize that working in the city of Bern will be associated with a higher seroprevalence than will working in other geographic areas of the canton (i.e. rural area).

iii) To monitor COVID-19 antibody titres and neutralizing capacity over time and to associate them with reinfection rates and infection-free intervals in police officers after accidental contact with a proven COVID-19 case. The investigators hypothesize that in seropositive individuals, there will be a decreasing dynamic of antibody titres over the one-year study period, and hence, a decrease of neutralizing capacity.

Eligibility criteria: Inclusion Criteria:

* Police officers of the cantonal police of Bern volunteering to participate in the study.

Exclusion Criteria:

* Refusal or inability to give informed consent or contraindication to venepuncture.

Primary outcomes:
measure: Seroprevalence
timeFrame: One year
Secondary outcomes:
measure: Risk profile assessment
timeFrame: One year
Other outcomes:
Locations:
city: Bern
country: Switzerland
facility: University of Bern, Institute for Infectious Diseases
state: BE
Study officials:
affiliation: University of Bern
name: Parham Sendi, MD
role: PRINCIPAL_INVESTIGATOR
References:
citation: Sendi P, Baldan R, Thierstein M, Widmer N, Gowland P, Gahl B, Buchi AE, Guntensperger D, Wider M, Blum MR, Tinguely C, Maillat C, Theel ES, Berbari E, Dijkman R, Niederhauser C. A Multidimensional Cross-Sectional Analysis of Coronavirus Disease 2019 Seroprevalence Among a Police Officer Cohort: The PoliCOV-19 Study. Open Forum Infect Dis. 2021 Oct 16;8(12):ofab524. doi: 10.1093/ofid/ofab524. eCollection 2021 Dec.