louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT00533065: Effects of Donepezil on Deficits Associated With Age-Related Decrease of Growth Hormone
Official title: Effects of the Cholinesterase Inhibitor Donepezil on Organic and Functional Deficits Associated With Age-Related Decrease of Growth Hormone
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Elderly
Keywords: Aging
Lead sponsor: Ludwig Boltzmann Gesellschaft
Sponsor class: OTHER
First posted: 2007-09-21
Enrollment: 80
Sex: ALL
Minimum age (years): 70
Maximum age (years): 80
Standard ages: OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: PREVENTION

Brief summary: The planned study has two purposes:

1. It is to provide evidence that the administration of a cholinesterase inhibitor will result in an increase of IGF-I (primary variable) and in an increase of the secretion growth hormone (secondary variable) that can be maintained throughout the treatment-period of one year.
2. The study also tests the hypothesis that maintenance of increased blood levels of growth hormone and IGF-I can stop or delay the age-related changes of body composition (secondary variables) .


Eligibility criteria: Inclusion Criteria:

* Aged between 70 and 80 years

Exclusion Criteria:

* Cardiac arrhythmias (sick sinus syndrome, AV block, sino-atrial block),
* Treatment with beta-blockers, NSAIDs or cholinergic agonists,
* Known hypersensitivity to donepezil hydrochloride, piperidine derivatives or to any excipients used in the formulation,
* Gastric and duodenal ulcer,
* Severe renal and hepatic impairment,
* Urinary congestion (prostatic hypertrophy),
* Obstructive pulmonary disease (bronchial asthma);

Primary outcomes:
measure: Serum IGF1
timeFrame: one year
Secondary outcomes:
measure: Growth hormone, body composition variables
timeFrame: one year
Other outcomes:
Locations:
city: Vienna
country: Austria
facility: Ludwig Boltzmann Institute
Study officials:
affiliation: Ludwig Boltzmann Institute of Aging Research
name: Karl H Tragl, MD
role: STUDY_DIRECTOR
References:
Clinical trial NCT04358965: Tranexamic Acid Versus Vaginal Misoprostol in Abdominal Myomectomy
Official title: Evaluating Safety and Efficacy of Tranexamic Acid Versus Vaginal Misoprostol in Reducing Intraoperative Blood Loss During Abdominal Myomectomy
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: PHASE4
Conditions: Myomectomy
Lead sponsor: Cairo University
Sponsor class: OTHER
First posted: 2020-04-24
Enrollment: 162
Sex: FEMALE
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: PREVENTION

Brief summary: the aim of the present study is to evaluate safety and efficacy of tranexamic acid versus vaginal misoprostol in reducing intraoperative blood loss during abdominal myomectomy


Eligibility criteria: Inclusion Criteria:

* symptomatic fibroids candidate for abdominal myomectomy

Exclusion Criteria:

* myomas candidate for laparoscopic or hysteroscopic myomectomy and allergy or contraindications to misoprostol or tranexamic acid

Primary outcomes:
measure: intraoperative blood loss
timeFrame: one hour
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
References:
Clinical trial NCT04115865: Assessment of Post-operative Sore Throat After Scheduled General Anesthesia
Official title: Assessment of Post-operative Sore Throat After Scheduled General Anesthesia
Study type: OBSERVATIONAL
Overall status: WITHDRAWN
Conditions: Sore Throat
Intubation;Difficult
Lead sponsor: University Hospital, Lille
Sponsor class: OTHER
First posted: 2019-10-04
Enrollment: 0
Sex: ALL
Minimum age (years): 6
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: Patient to be operated on in the Department of Surgical Specialties, Neurosurgery, Orthopaedics and Pediatric Surgery at the University Hospital of Lille

Brief summary: Precise description of the technique for intubation or laryngeal mask placement during general anesthesia Research on factors that can influence sore throat due to the placement of an endobuccal or endotracheal device during general anesthesia


Eligibility criteria: Inclusion Criteria:

- General Anesthesia required Endotracheal or endobuccal device

Exclusion Criteria:

* Tracheotomy per or post surgery
* Patient with pre-operative pharyngeal irritation.
* Patient with a prior respiratory tract infection.
* Surgery of the laryngeal or tracheal vein, old or new
* Surgery scheduled less than 24 hours ago.

Primary outcomes:
measure: Incidence of sore throat
timeFrame: Within 24 hours of surgery
Secondary outcomes:
measure: Severity of sore throat,
timeFrame: At exit of the post-interventional monitoring room, at 24 hours of surgery or exit of hospital
measure: type of sore throat risk factor
timeFrame: At exit of the post-interventional monitoring room, at 24 hours of surgery or exit of hospital
Other outcomes:
Locations:
Study officials:
affiliation: University Hospital, Lille
name: Elsa Jozefowicz, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT06401265: Recalling the Treatment and Prognosis of Upper Tract Urothelial Cancer (UTUC)
Official title: Recalling the Treatment and Prognosis of Upper Tract Urothelial Cancer (UTUC)
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Uterine Cancer
Lead sponsor: Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation
Sponsor class: OTHER
First posted: 2024-05-06
Enrollment: 8000
Sex: ALL
Minimum age (years): 18
Maximum age (years): 100
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: CASE_CONTROL
Time perspective: RETROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Patients with upper urinary tract urothelial carcinoma

Brief summary: Among urothelial cancers, upper urinary tract urothelial cancers, including renal pelvis and ureteral cancers have a higher incidence rate in Taiwan than Western countries. In particular, the proportion of female patients is similar to that of males. This situation is significantly different from that in foreign countries. The cause is currently uncertain.In the past, the arsenic contamination of groundwater made blackfoot disease become common and malignant in areas. Now, the number of kidney dialysis patients in Taiwan is increasing; and according to statistics, there is a significantly higher incidence of urothelial cancer among kidney dialysis patients. This may be caused by the use of traditional Chinese medicine or other unknown reasons.


Eligibility criteria: Inclusion Criteria:

* Case study of upper urinary tract urothelial cancer surgery

Exclusion Criteria:

* Cases of surgery for non-upper urinary tract urothelial cancer

Primary outcomes:
measure: It is a retrospective and questionnaire-based study.
timeFrame: Patients with urothelial carcinoma of the upper urinary tract from January 2008 to December 2019.
Secondary outcomes:
Other outcomes:
Locations:
city: Taipei
country: Taiwan
facility: Tzu Chi hospital
Study officials:
References:
Clinical trial NCT02198365: Comparison of Human Papillomavirus Integrated DNA and Messenger RNA in Cervical Neoplasia
Official title: Comparison of Human Papillomavirus Integrated DNA and Messenger RNA for Detection and Prediction in Progression of Cervical Neoplasia
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Cervical Intraepithelial Neoplasia
Keywords: mRNA,
DNA,
integrated HPV DNA
human papillomavirus,
cervical neoplasia
Lead sponsor: Cathay General Hospital
Sponsor class: OTHER
Collaborators: name: National Science and Technology Council, Taiwan
First posted: 2014-07-23
Enrollment: 250
Sex: FEMALE
Minimum age (years): 20
Maximum age (years): 80
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: CASE_CONTROL
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: We will examine 250 baseline liquid-based cytology specimens from women with 100 low-grade squamous intraepithelial lesions (LSILs), 100 high-grade squamous intraepithelial lesions (HSILs), 10 microinvasions and 40 invasive cervical cancers.

Brief summary: The investigators hypothesis is HPV integration could result in expression of oncogene transcripts, and not only constitutive expression but also the level of expression will be decisive for transformation and the maintenance of the malignant phenotype. Moreover, the expression and level of HPV viral transcripts not HPV DNA viral loads is correlated to the severity in cervical intraepithelial neoplasia (CIN) and cervical carcinomas (CxCa).

Detailed description: In the investigators proposal, the investigators will examine at least 250 baseline liquid-based cytology specimens from women with normal cytology, low-grade squamous intraepithelial lesions (LSILs), high-grade squamous intraepithelial lesions (HSILs), microinvasions and invasive cervical cancers. Specimens will be tested for HPV DNA using HPV blot and type-specific PCR including type 16, 18, 52, 58, 31, 33, 39, 45, 51, 56, 59, 68, 6, and 11. Cervical specimens from women with HPV DNA types 16, 18, 52, 58, 31 and 33, which are the most prevalent oncogenic types in Taiwan, will be examined for physical status of viral DNA tested by real-time PCR and FISH, along with level of expression in mRNA.

Eligibility criteria: Inclusion Criteria:

* cervical neoplasia

  * HPV infection patient

Exclusion Criteria:

* no HPV infection

  * no intra-epithelial neoplasia lesion

Primary outcomes:
measure: level of mRNA expression
timeFrame: 12 month
Secondary outcomes:
measure: The integrated HPV DNA
timeFrame: 12 months
Other outcomes:
Locations:
city: Taipei
country: Taiwan
facility: Cathay General Hospital
Study officials:
affiliation: Gynecologic Cancer Center, Cathay General Hospital
name: Chih-Ming Ho
role: STUDY_CHAIR
References:
Clinical trial NCT01316965: Impact of a Multifaceted Program to Prevent Postoperative Delirium in the Elderly
Official title: CONFUCIUS Study : Impact of a Multifaceted Program to Prevent Postoperative Delirium in the Elderly
Study type: INTERVENTIONAL
Overall status: TERMINATED
Phase: NA
Conditions: Postoperative Delirium
Keywords: Postoperative delirium
elderly
prevention
stepped wedge design
healthcare workers
Lead sponsor: Hospices Civils de Lyon
Sponsor class: OTHER
First posted: 2011-03-16
Enrollment: 175
Sex: ALL
Minimum age (years): 75
Standard ages: OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: PREVENTION

Brief summary: Postoperative delirium is common in the elderly and is associated with a significant increase in mortality, complications, length of hospital stay and admission in long care facility. Several interventions have proved their effectiveness to prevent it but their combination within a multifaceted intervention needs to be assessed using rigorous methodology based on randomized study design. CONFUCIUS trial aims to measure the impact of a multifaceted program on the prevention of postoperative delirium in elderly.


Eligibility criteria: Inclusion Criteria:

* Male or female subject aged over 75 years
* Admission for a scheduled surgery (i.e. all oncologic digestive surgery , ureterostomy, nephrectomy or cystectomy, total hip or knee replacement)
* Participation agreement

Exclusion Criteria:

* Patients with a progressive and/or poorly managed psychiatric pathology (patients with stabilized depression could be included in the study)

Primary outcomes:
measure: Postoperative delirium rate within 7 days after surgery
timeFrame: 7 days after surgery
Secondary outcomes:
measure: Mean delirium intensity within 7 days after surgery
timeFrame: 7 days after surgery
measure: Length of hospital stay
timeFrame: Hospital discharge
measure: Postoperative complications 30 days after surgery incidence
timeFrame: 30 days after surgery
measure: Mortality 6 months after surgery
timeFrame: 6 months after surgery
measure: Feasibility of the multidisciplinary prevention program
timeFrame: 24 months
Other outcomes:
Locations:
city: Villeurbanne
country: France
facility: Hospices Civils de Lyon-Hôpital des Charpennes
Study officials:
affiliation: Hospices Civils de Lyon- Hôpital des Charpennes
name: Pierre KROLAK-SALMON, Pr
role: PRINCIPAL_INVESTIGATOR
References:
citation: Mouchoux C, Rippert P, Duclos A, Fassier T, Bonnefoy M, Comte B, Heitz D, Colin C, Krolak-Salmon P. Impact of a multifaceted program to prevent postoperative delirium in the elderly: the CONFUCIUS stepped wedge protocol. BMC Geriatr. 2011 May 18;11:25. doi: 10.1186/1471-2318-11-25.
Clinical trial NCT05223465: Faculty and Students' Attitude Toward E-learning
Official title: Faculty and Students' Attitude Toward E-learning at the Start of the COVID-19 Pandemic: A Cross-sectional Study
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: E Learning
Medical Education
Keywords: Medical Education
E-learning
COVID-19
Students' attitude
Facultys' attitude
Lead sponsor: Hawler Medical University
Sponsor class: OTHER
First posted: 2022-02-04
Enrollment: 1896
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: OTHER
Time perspective: CROSS_SECTIONAL
Sampling method: NON_PROBABILITY_SAMPLE
Study population: The population is composed of students studying in colleges of Haler Medical University (Medicine, Dentistry, Pharmacy, nursing and health science) in addition to faculty staff working in the above-mentioned colleges

Brief summary: E-learning in medical education is a relatively new idea that is rapidly growing. This study aimed to assess the students and faculty staff attitude for e-learning at the emergence of COVID-19.

A prospective cross-sectional online survey based on Google form was conducted at a medical university in Iraq between March and April 2020

Detailed description: E learning provides education at a generally lower cost and engages learners at a time and location that is most appropriate for them. Recent calls for reform in medical education and training have emphasized the use of information technology-empowered learning. This was enhanced more in the COVID-19 era . Some international organizations, such as the World Health Organization (WHO), have acknowledged e-learning as a helpful tool for healthcare education, particularly in developing countries. Nevertheless, the use of e-learning by the faculty members and students stayed minimum for uploading lecture notes, course books, feedbacks, and providing marks until the COVID-19 pandemic raised that need. This study aimed to evaluate faculty and students' knowledge and attitudes toward e-learning at the emergence of COVID-19 and identify the potential requirements for implementing e-learning.

An online survey was distributed to a sample of 190 faculty and 1706 students of a medical university in Iraq. Knowledge and attitudes towards e-learning were studied

Eligibility criteria: Inclusion Criteria:

* undergraduate students faculty staff working in Hawler Medical University

Exclusion Criteria:

* Faculty staff who are on leave for study or health purpose

Primary outcomes:
measure: Knowledge
timeFrame: At the beginning of the study
measure: Attitude
timeFrame: At the beginning of the study
Secondary outcomes:
measure: Opinion
timeFrame: At the beginning of the study
Other outcomes:
Locations:
city: Erbil
country: Iraq
facility: Nazdar Ezzaddin Alkhateeb
state: Kurdistan Region
Study officials:
affiliation: Hawler Medical University
name: Nazdar E Alkhateeb, PhD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT04995965: Infections With Enterobacteria Producing Carbapenemases at the University Hospitals of Strasbourg
Official title: Infections With Enterobacteria Producing Carbapenemases at the University Hospitals of Strasbourg - Descriptive Epidemiology and Risk Factors for Infection in the Event of Colonization
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Nfections, Enterobacterial
Keywords: nfections, Enterobacterial
carbapenemases
producers of a carbapenemase
Lead sponsor: University Hospital, Strasbourg, France
Sponsor class: OTHER
First posted: 2021-08-09
Enrollment: 274
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Observational model: CASE_ONLY
Time perspective: RETROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Major subject with clinical sample or rectal screening smear finding an enterobacterium producing a carbapenemase

Brief summary: Infections with enterobacteria producing carbapenemases at the University Hospitals of Strasbourg - descriptive epidemiology and risk factors for infection in the event of colonization

There is a worrying situation of an increase in the number of patients colonized with carbapenemase-producing Enterobacteriaceae (CPE) at HUS.

7 to 15% of patients colonized with EPC would develop an infection with EPC. The cohorts published mainly concern patients hospitalized in intensive care. The associated mortality reported in the literature is high (\> 25%) and greater than that associated with infection with the same bacterium sensitive to carbapenems.


Eligibility criteria: Inclusion criteria:

* Major subject (≥18 years old)
* Subject hospitalized at HUS between 01/01/2011 and 07/31/2021
* Clinical sample or rectal screening smear finding an enterobacterium producing a carbapenemase (EPC)
* Subject not having expressed their opposition to participating in the study

Exclusion criteria:

* Subject having expressed opposition to participating in the study
* Subject under guardianship or guardianship
* Subject under safeguard of justice

Primary outcomes:
measure: Retrospective study of Enterobacteriaceae infections producing carbapenemases
timeFrame: Files analysed retrospectively from January 01, 2011 to July 31, 2021 will be examined]
Secondary outcomes:
Other outcomes:
Locations:
city: Strasbourg
country: France
facility: Service de maladies infectieuses et tropicales - Hôpitaux Universitaires de Strasbourg
Study officials:
affiliation: Service de maladies infectieuses et tropicales - Hôpitaux Universitaires de Strasbourg
name: Yves HANSMANN, MD, PhD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT02762565: Clinical Utility of a Low-Cost Hand-Held Breast Scanner
Official title: Clinical Utility of a Low-Cost Hand-Held Breast Scanner
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Symptomatic Breast Lump
Lead sponsor: Abramson Cancer Center at Penn Medicine
Sponsor class: OTHER
First posted: 2016-05-05
Enrollment: 89
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: DIAGNOSTIC

Brief summary: Early detection of breast cancer improves the survival rate and makes treatment less costly. This study would measure the accuracy a low-cost hand-held commercially viable device, iBE, for the detection of clinically relevant findings in the breast using the results of current mammography as a comparison. This research will have no impact on clinical decision making.


Eligibility criteria: Inclusion Criteria:

* 18 years of age and older
* Women and men with symptomatic breast lump (either by palpation or imaging) OR
* Asymptomatic women presenting to the imaging center for a screening mammogram.
* Signed Informed Consent

Exclusion Criteria:

* Patients under 18 years of age
* Patients who previously participated in this study and are returning to the Women's Imaging Center for follow-up diagnostic tests

Primary outcomes:
measure: Number of Quadrants With Detected Breast Lesions
timeFrame: 3 months
measure: Sensitivity of iBE Breast Lesion Detection
timeFrame: 1 day
measure: Specificity of iBE Breast Lesion Detection
timeFrame: 1 day
Secondary outcomes:
Other outcomes:
Locations:
city: Philadelphia
country: United States
facility: Abramson Cancer Center of the University of Pennsylvania
state: Pennsylvania
Study officials:
affiliation: Abramson Cancer Center at Penn Medicine
name: Ari Brooks, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT06992765: Evaluation of Green Tea for Improving Blood Lipid Profile
Official title: Evaluation of Heysong Japanese Green Tea for Improving Blood Lipid Function
Study type: INTERVENTIONAL
Overall status: ACTIVE_NOT_RECRUITING
Phase: NA
Conditions: Hypercholesterolemia
Keywords: Green tea
Cholesterol
Triglyceride
Blood lipid
Lead sponsor: Taipei Medical University
Sponsor class: OTHER
Collaborators: name: Eagletek Corp.
First posted: 2025-05-28
Enrollment: 38
Sex: ALL
Minimum age (years): 18
Maximum age (years): 65
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: SUPPORTIVE_CARE

Brief summary: The objects of this study are to evaluate the effects of the "Heysong japanese green tea" on the human subjects who are dyslipidemia. In this trial, 40 healthy subjects whose ages are 18\~65 years old (20 for placebo and 20 for experimental) will be included. The total experiment will be 16 weeks and the intervention period will be 12 weeks, within which, at wk 0, 2, 8, 14 and 16, serum triglyceride (TG), total cholesterol (TC), high density lipoprotein cholesterol (HDL-C) and low density lipoprotein cholesterol (LDL-C) values would be measured. Urine/feces samples and anthropometric data will also be acquired. The results will be analyzed according to the methods published by the Ministry of Health and Welfare of Taiwan Food and Drug Administration.


Eligibility criteria: Inclusion Criteria:

* Male and female. Age between 18-65 years old.
* Those who have been assessed as dyslipidemia by a family physician but have not yet required medication. The following measurement values were used as evaluation criteria:

  1. Hypercholesterolemia: plasma total cholesterol (TC) \>200 mg/dL;
  2. Mixed hyperlipidemia: plasma total cholesterol (TC) \>200 mg/dL , triglyceride (TG) \>200 mg/dL;
  3. Hypertriglyceridemia: plasma triglyceride (TG) \>200 mg/dL, and high-density lipoprotein cholesterol (HDL-C) \< 35 mg/dL or TC/HDL-C \>5.

Exclusion Criteria:

* Pregnant, breastfeeding, menopausal women.
* Take any drugs or supplements that can affect blood lipid levels 2 weeks before or during the experiment.
* People with intolerance to caffeine or green tea.
* People who take drugs for chronic diseases.
* People who smoke or drink alcohol.

Primary outcomes:
measure: Serum total cholesterol
timeFrame: Wk(-2), Week(0) (Baseline), Wk(6), Wk(12) and Wk(14)
Secondary outcomes:
Other outcomes:
Locations:
city: Taipei
country: Taiwan
facility: Taipei Medical University
Study officials:
References: