louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT04030481: Effects of Anesthetic Techniques on Renal Function
Official title: Different Effects of Two Anesthetic Techniques on Renal Function During the Perioperative Period of Cardiac Surgery in Children
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Congenital Heart Disease
Acute Kidney Injury
Keywords: propofol,sevoflurane
Lead sponsor: Children's Hospital of Fudan University
Sponsor class: OTHER
First posted: 2019-07-24
Enrollment: 60
Sex: ALL
Minimum age (years): 1
Maximum age (years): 3
Standard ages: CHILD
Accepts healthy volunteers: no
Observational model: CASE_CONTROL
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: After approved by the ethics committee, sixty patients who met the inclusion criteria of this study with their parents' informed consent in Children's Hospital of Fudan University.

Brief summary: This study evaluates Different effects of two anesthetic techniques on renal function during the perioperative period of cardiac surgery in children.

Detailed description: Acute kidney injury is one of the major complications after heart surgery, which increases the mortality of patients. Therefore, early prevention and detection of acute kidney injury is particularly important. In recent years, more and more studies have shown that both sevoflurane, an inhaled anesthetic widely used in clinical practice, and propofol, an intravenous anesthetic, have protective effects on kidneys. The aim of this study was to investigate the perioperative effects of two different anesthetic techniques on renal function for pediatric cardiac surgery.

Eligibility criteria: Inclusion Criteria:

* children with congenital heart disease
* \<3 years of age

Exclusion Criteria:

* preoperative renal insufficiency;
* renal malformation, kidney absence

Primary outcomes:
measure: renal blood flow
timeFrame: 2 days
Secondary outcomes:
measure: neutrophil gelatinase-associated lipocalin , NGAL
timeFrame: 2 days
measure: creatinine
timeFrame: 3 and 4 days
measure: Mean arterial pressure
timeFrame: 2 days
measure: cardiopulmonary bypass (CPB) time
timeFrame: 24 hours
Other outcomes:
Locations:
city: Shanghai
country: China
facility: Children's Hospital of Fudan University
state: Shanghai
Study officials:
affiliation: Shanghai Children's Medical Center
name: mazhong zhang, MD
role: STUDY_DIRECTOR
References:
Clinical trial NCT01258881: Retrospective Study of Ovarian Cancer Patients With Brain Metastasis
Official title: Retrospective Study of Ovarian Cancer Patients With Brain Metastasis
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Ovarian Cancer
Brain Metastases
Lead sponsor: National Taiwan University Hospital
Sponsor class: OTHER
First posted: 2010-12-13
Enrollment: 70
Sex: FEMALE
Minimum age (years): 25
Maximum age (years): 80
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: CASE_ONLY
Time perspective: RETROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: ovarian cancer patients with brain metastasis

Brief summary: Ovarian cancer, especially epithelial ovarian carcinoma, has the highest mortality rate among the gynecologic malignancies. The majority of patients with epithelial ovarian carcinoma are diagnosed at advanced stage which has the overall survival rates of only 19-30%. As the advance in the managements which prolonged the overall survival, metastatic lesion in rare location such as brain was noted in few patients of ovarian cancer in recent years. In the retrospective study, the investigators will review the medical records of the ovarian cancer patients with brain metastasis in the investigators hospital to investigate the incidence, clinical courses, optimal managements and possible prognostic factors in the rare condition.

Detailed description: The ovarian cancer patient treated at the Department of Obstetrics and Gynecology of the National Taiwan University Hospital were retrospectively collected. The cancer registration database was searched for the patients with ovarian carcinoma who brain metastases were also diagnosed. The medical records of these patients were reviewed with particular attention to the results of histo-pathological and radiologic reports. Patients with other synchronous primary brain tumor were excluded. The initial management of primary tumor, including the surgery and adjuvant chemotherapy, and the clinical courses and disease status, such as remission, recurrence and progression, were all carefully reviewed. The intra-cranial lesions were all diagnosed by imaging studies, including brain computed tomography (CT) and magnetic resonance imaging (MRI) scans. Therapeutic strategies for the metastatic lesions in the brain were also reviewed. All statistical analyses were performed using the SPSS 13.0 statistical software for Windows. P\<0.05 was defined as statistical significance. Survival was measured from the time of initial diagnosis of brain metastasis until the date of death or last contact, and was presented by Kaplan-Meier curves.

Eligibility criteria: Inclusion Criteria:

* Patients with ovarian cancer and brain metastasis
* Patients ovarian cancer from National Taiwan University Hospital

Exclusion Criteria:

* none

Primary outcomes:
Secondary outcomes:
Other outcomes:
Locations:
city: Taipei
country: Taiwan
facility: National Taiwan University Hospital
Study officials:
affiliation: National Taiwan University Hospital
name: Wen-Fang Cheng, Professor
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT03160781: Intraosseous PRP for Knee Osteoarthritis: Pilot Study
Official title: Pilot Study to Evaluate Combination of Intraosseous With Intra-articular Infiltrations of Plasma Rich in Growth Factors (PRGF®-Endoret®) in the Treatment of Knee Osteoarthritis.
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE2
Conditions: Knee Osteoarthritis
Lead sponsor: Unidad de Cirugía Artroscópica
Sponsor class: OTHER
First posted: 2017-05-19
Enrollment: 19
Sex: ALL
Minimum age (years): 40
Maximum age (years): 77
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: TREATMENT

Brief summary: The aim of this study was to assess a novel approach to treating severe knee osteoarthritis by targeting synovialmembrane, superficial articular cartilage, synovial fluid, and subchondral bone by combining intra-articular injections and intraosseous infiltrations of platelet rich plasma.This study explored a new strategy consisting of intraosseous infiltrations of platelet rich plasma into the subchondral bone in combination with the conventional intra-articular injection in order to tackle several knee joint tissues simultaneously.


Eligibility criteria: Inclusion Criteria:

* Patients of both sexes aged 40 to 77 years.
* Predominant internal tibiofemoral knee osteoarthritis.
* Joint pain above 2.5 VAS points.
* Radiographic severity degrees 3 and 4 according to Ahlbäck scale.
* Values of body mass index between 20 and 33.
* Possibility for observation during the follow-up period.

Exclusion Criteria:

* Bilateral knee osteoarthritis which requires infiltration in both knees.
* Values of body mass index \> 33.
* Polyarticular disease diagnosed.
* Severe mechanical deformity (diaphyseal varus of 4∘ and valgus of 16∘).
* Arthroscopy in the last year prior to treatment.
* Intra-articular infiltration of hyaluronic acid in the past 6 months.
* Systemic autoimmune rheumatic disease (connective tissue diseases and systemic necrotizing vasculitis).
* Poorly controlled diabetes mellitus (glycosylated hemoglobin above 9%).
* Blood disorders (thrombopathy, thrombocytopenia, and anemia with Hb \< 9).
* Undergoing immunosuppressive therapy and/or warfarin.
* Treatment with corticosteroids during the 6 months prior to inclusion in the study.

Primary outcomes:
measure: Pain according to KOOS scale at 6 months after treatment
timeFrame: 6 months
Secondary outcomes:
measure: Symptoms according to KOOS scale at 6 months after treatment
timeFrame: 6 months
measure: Function according to KOOS scale at 6 months after treatment
timeFrame: 6 months
measure: Sport Activity according to KOOS scale at 6 months after treatment
timeFrame: 6 months
measure: QoL according to KOOS scale at 6 months after treatment
timeFrame: 6 months
Other outcomes:
Locations:
Study officials:
References:
Clinical trial NCT02895581: Retrospective Study of the Survival of Patients Suffering From Hiv-related Progressive Multifocal Leukoencephalopathy
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Progressive Multifocal Leukoencephalopathy
Lead sponsor: Fondation Ophtalmologique Adolphe de Rothschild
Sponsor class: NETWORK
First posted: 2016-09-09
Enrollment: 34
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: CASE_ONLY
Time perspective: RETROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: HIV-infected patients diagnosed with progressive multifocal leukoencephalopathy

Brief summary: Retrospective medical chart review of HIV-infected patients diagnosed with progressive multifocal leukoencephalopathy


Eligibility criteria: Inclusion Criteria:

* HIV infected patients
* Diagnosed with progressive multifocal leukoencephalopathy
* Minimal follow-up of one year OR patient deceased less than one year after diagnosis

Exclusion Criteria:

* Loss of follow-up within 12 months after diagnosis

Primary outcomes:
measure: Rankin score
timeFrame: 12 months after diagnosis of leukoencephalopathy
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
References:
Clinical trial NCT01978795: Interactive Training in Sports Concussion Prevention and Management
Official title: The Effectiveness of a Web-Based Resource in Improving Post-Concussion Management in High Schools
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE2
Conditions: Concussion
Keywords: concussion
high school
web-based training
school-based health care
Lead sponsor: Oregon Center for Applied Science, Inc.
Sponsor class: INDUSTRY
Collaborators: name: Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
First posted: 2013-11-08
Enrollment: 25
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL

Brief summary: This study evaluated Brain 101: The Concussion Play book, an intervention that provides education and resources on concussion management for high schools. The study hypotheses were that athletes and parents who viewed the Brain 101 program would demonstrate increased knowledge and self efficacy in concussion management, and that use of the intervention would positively affect school concussion management practices.


Eligibility criteria: Inclusion Criteria for participating schools:

* athletic trainer (AT) on staff or contracted by school for services
* school access to a high-speed internet connection
* agreement to expose all students participating in fall sports to the training.

Exclusion Criteria:

* didn't meet inclusion criteria

Primary outcomes:
measure: Change in youth athlete and parent knowledge of effective sports concussion management from before and after intervention exposure
timeFrame: Pre: Participants completed the measure an average of 30 minutes prior to being exposed to the intervention. Post: Participants completed the measure an average of 30 minutes after exposure to the intervention
Secondary outcomes:
measure: Change in youth athlete and parent ratings of self-efficacy in sports concussion management
timeFrame: Pre: Participants completed the measure an average of 30 minutes prior to being exposed to the intervention. Post: Participants completed the measure an average of 30 minutes after exposure to the intervention
Other outcomes:
measure: Implementation of effective concussion management guidelines
timeFrame: 3 months post intervention
Locations:
city: Eugene
country: United States
facility: Oregon Center for Applied Science
state: Oregon
Study officials:
affiliation: Oregon Center for Applied Science
name: Ann E Glang, PhD
role: PRINCIPAL_INVESTIGATOR
References:
citation: Glang AE, Koester MC, Chesnutt JC, Gioia GA, McAvoy K, Marshall S, Gau JM. The effectiveness of a web-based resource in improving postconcussion management in high schools. J Adolesc Health. 2015 Jan;56(1):91-7. doi: 10.1016/j.jadohealth.2014.08.011. Epub 2014 Oct 29.
Clinical trial NCT03904095: Comparison Between the Analgesic Efficacy of Erector Spinae Plane Block and Psoas Compartment Block in Hip Surgery
Official title: Comparison Between the Analgesic Efficacy of Erector Spinae Plane Block and Psoas Compartment Block in Hip Surgery
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Hip Arthropathy
Keywords: Erector spinae block
hip arthroplasty
postoperative analgesia
psoas compartment block
ultrasound
Lead sponsor: TC Erciyes University
Sponsor class: OTHER
First posted: 2019-04-04
Enrollment: 105
Sex: ALL
Minimum age (years): 18
Maximum age (years): 65
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Intervention model description: Patients randomly allocated to three treatment groups: , The psoas compartment block (Group I) the ESP block group (Group II) and the control group (Group III). Blocks performed after general anesthesia induction with the Ultrasound while patients lying on surgical type at the top.
Primary purpose: TREATMENT

Brief summary: To evaluate the ability of Erector spina Plane block and Psoas compartment block to decrease postoperative pain and analgesia requirements in patients undergoing hip surgery.

Detailed description: Erector spina Plane block or Psoas compartment block will performed with guided ultrasound at L4 Transverse process level would lead to adequate postoperative analgesia ,in total hip arthroplasty surgeries.

Eligibility criteria: Inclusion Criteria:

ASA (American Society of Anesthesiologists) I- ASA II Patients

-

Exclusion Criteria:

* history of allergy to the study medication
* refusal to participate

Primary outcomes:
measure: opioid consumption
timeFrame: 24 hours after surgery
measure: Verbal analog Pain Scores on rest and movement
timeFrame: 24 hours after surgery
Secondary outcomes:
measure: incidences of adverse effects (like nausea and vomiting)
timeFrame: 24 hours after surgery
Other outcomes:
Locations:
city: Kayseri
country: Turkey
facility: Sibel Seçkin Pehlivan
state: Talas
Study officials:
affiliation: TC Erciyes University
name: Sibel Pehlivan
role: STUDY_DIRECTOR
References:
citation: Touray ST, de Leeuw MA, Zuurmond WW, Perez RS. Psoas compartment block for lower extremity surgery: a meta-analysis. Br J Anaesth. 2008 Dec;101(6):750-60. doi: 10.1093/bja/aen298. Epub 2008 Oct 22.
citation: Tsui BCH, Fonseca A, Munshey F, McFadyen G, Caruso TJ. The erector spinae plane (ESP) block: A pooled review of 242 cases. J Clin Anesth. 2019 Mar;53:29-34. doi: 10.1016/j.jclinane.2018.09.036. Epub 2018 Oct 3.
citation: Tulgar S, Ermis MN, Ozer Z. Combination of lumbar erector spinae plane block and transmuscular quadratus lumborum block for surgical anaesthesia in hemiarthroplasty for femoral neck fracture. Indian J Anaesth. 2018 Oct;62(10):802-805. doi: 10.4103/ija.IJA_230_18.
Clinical trial NCT04964895: Sexual Quality of Patients After Bladder Cancer Cystectomy
Official title: Sexual Quality of Patients After Bladder Cancer Cystectomy : A Prospective Observational Study
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Sexual Dysfunction
Keywords: bladder cancer
cystectomy
sex life
sex quality
Lead sponsor: University Hospital, Toulouse
Sponsor class: OTHER
First posted: 2021-07-16
Enrollment: 50
Sex: ALL
Minimum age (years): 18
Maximum age (years): 100
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Intervention model description: Prospective observational study
Primary purpose: SUPPORTIVE_CARE

Brief summary: Bladder cancer is the second most prevalent urological cancer in France. About 1 in 5 new cases of bladder cancer infiltrate the muscles. The standard treatment is neoadjuvant chemotherapy followed by radical cystectomy associated with reconstruction of the urinary tract. The short-term effects on well-being and quality of life are well known. The long-term effects are, on the other hand, poorly understood, particularly sexual function. This study aim to asses the quality of sexual life in patients with cystectomy for bladder cancer. This will be done via various questionnaires given before and after surgery.

Detailed description: The study is a prospective observational cohort study of the quality of sexual life in patients with cystectomy for bladder cancer. Data is collected via Qlq-C30, EORTC-Shq22, MSHQ if male, Female Sexual Function Index (FSFI) questionnaires that the patients complete by themselves. They are given before surgery and then 8 months after surgery.

The study consists of the compilation of relevant clinical data and questionnaire results.

Eligibility criteria: Inclusion Criteria:

* Any adult patient who had a cystectomy for bladder cancer
* Affiliated with a social security scheme

Exclusion Criteria:

* No Cystectomy
* Cystectomy for neurological etiology
* Pregnant or breastfeeding women

Primary outcomes:
measure: Evaluation of the decrease in the quality of sexual life of patients who had a cystectomy
timeFrame: T0 : before surgery
measure: Evaluation of the decrease in the quality of sexual life of patients who had a cystectomy
timeFrame: T1 : 8 months after surgery
Secondary outcomes:
measure: Evaluation of the decrease in the quality of life of patients who had a cystectomy
timeFrame: T0 : before surgery
measure: Evaluation of the decrease in the quality of life of patients who had a cystectomy
timeFrame: T1 : 8 months after surgery
Other outcomes:
Locations:
city: Toulouse
country: France
facility: University Hospital Toulouse
Study officials:
affiliation: University Hospital, Toulouse
name: Eric Huyghe, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT00356395: Safety and Effects of Ramipril Combined With Candesartan
Official title: Cardiovascular and Metabolic Effects of Combination Therapy With Ramipril and Candesartan In Hypertensive Patients
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE4
Conditions: Hypertension
Keywords: endothelial function, insulin resistance, adipocytokines
Lead sponsor: Gachon University Gil Medical Center
Sponsor class: OTHER
First posted: 2006-07-26
Enrollment: 40
Sex: ALL
Minimum age (years): 35
Maximum age (years): 75
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: CROSSOVER
Primary purpose: TREATMENT

Brief summary: we hypothesized that combination therapy has additive beneficial effects to improve endothelial dysfunction and adipocytokine profiles in patients with hypertension.

Detailed description: Forty patients will be given ramipril 10 mg and placebo, ramipril 10 mg and candesartan 16 mg, or candesartan 16 mg and placebo daily in a randomized, double-blind, placebo-controlled cross-over trial with three treatment arms and two washout periods (each 2 months).

Eligibility criteria: Inclusion Criteria:

* patients with mild to moderate hypertension

Exclusion Criteria:

* We will exclude patients with severe hypertension, unstable angina, acute myocardial infarction, or renal insufficiency.

Primary outcomes:
measure: comparison of endothelium-dependent dilation among the 3 treatment schemes
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
affiliation: Cardiology, Gil Heart Center, Gachon Medical School
name: Kwang K Koh, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT05647395: Effects of Different Deflation Methods on Coughing Response and Hemodynamics During Extubation
Official title: Effects of Different Deflation Methods on Coughing Response and Hemodynamics During Extubation
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Deflating Method
Keywords: Deflating method
Extubation phase
Coughing reaction
Lead sponsor: Yangzhou University
Sponsor class: OTHER
First posted: 2022-12-12
Enrollment: 90
Sex: ALL
Minimum age (years): 18
Maximum age (years): 65
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: PREVENTION

Brief summary: Patients with endotracheal intubation and general anesthesia often have severe choking and hemodynamic fluctuations during the extubation period, which increases the risk of cerebrovascular accident, arrhythmia, incision bleeding and so on . This study aimed to observe the effects of different methods of deflating of endotracheal tube cuffs on cough response and hemodynamics during periextubation in patients undergoing general anesthesia surgery.


Eligibility criteria: Inclusion Criteria:

1. Elective endotracheal intubation under general anesthesia.
2. Operation time \< 3 h.
3. ASA grade I or II.
4. Age 18\~65 years old.

Exclusion Criteria:

1. Throat and neck surgery.
2. Those assessed to have a high risk of reflux aspiration.
3. Difficulty intubation.
4. History of snoring before surgery.
5. Recent respiratory illness such as chronic cough.
6. Previous airway hyperresponsiveness, such as asthma.
7. recent use of cough suppressants.
8. Patients with severe heart, liver and kidney diseases.

Primary outcomes:
measure: Grading of cough reaction
timeFrame: During extubation procedure
measure: Change in Blood pressure
timeFrame: Preoperatively, immediately before extubation, immediately after extubation, 1 minute after extubation, 3 minutes after extubation, 10 minutes after extubation
measure: Change in Heart rate
timeFrame: Preoperatively, immediately before extubation, immediately after extubation, 1 minute after extubation, 3 minutes after extubation, 10 minutes after extubation
Secondary outcomes:
measure: Adverse reactions
timeFrame: Within 24 hours after removal of the endotracheal tube
Other outcomes:
Locations:
city: Yangzhou
country: China
facility: the Affiliated Hospital of Yangzhou University, Yangzhou University
state: Jiangsu
Study officials:
References: