Clinical trial NCT04803656: Assessment of Pulmonary Functions and Peripheral Muscle Strength of COPD Patients in Different GOLD Stages
Official title: Pulmonary Functions and Peripheral Muscle Strength and Their Relationship With Disease Duration and Prognosis in Patients With Different COPD Stages
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Copd
Keywords: COPD
Pulmonary functions
Respiratory muscle strength
Peripheral muscle strength
Lead sponsor: Marmara University
Sponsor class: OTHER
First posted: 2021-03-18
Enrollment: 31
Sex: ALL
Minimum age (years): 40
Maximum age (years): 80
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Intervention model description: COPD patients: Respiratory muscle strength, peripheral muscle strength in both upper and lower extremity were evaluated. Pulmonary function tests obtained during routine controls of patients.
Primary purpose: HEALTH_SERVICES_RESEARCH

Brief summary: The purpose of this research was to examine the respiratory functions, respiratory muscle strength and peripheral muscle strength of patients with COPD in different groups and to evaluate their correlation with the duration and prognosis of the disease in COPD.

Detailed description: Chronic obstructive pulmonary disease (COPD) is a common disease characterized by airway obstruction against harmful particles and gases in the airway and lungs, and is progressive, treatable and preventable.

The severity of the disease in COPD is determined according to the GOLD (Global Initiative for Chronic Obstructive Lung Disease) guidelines (2). While determining the severity of airway obstruction with the patient's spirometric values in COPD; Combined COPD assessment is made with symptomatic evaluation, number of exacerbations and hospitalizations. Airway restriction is numerically (GOLD 1-4), symptom evaluation and exacerbation risk combined with letter grouping (Group A-D).

There is a loss of respiratory and peripheral muscle strength in COPD patients. A mixture of various local and systemic causes was responsible for respiratory muscle dysfunction in COPD. Immobility, systemic inflammation, hypoxia of the tissue, oxidative stress and increased apoptosis of the skeletal muscle have been identified as possible pathogenic factors for loss of peripheral muscle strength in COPD patients.

it was aimed to evaluate the respiratory functions, respiratory muscle strength and peripheral muscle strength of patients with different COPD groups clinically and to evaluate their correlation with the duration and prognosis of the disease.

Eligibility criteria: Inclusion Criteria:

* Being in COPD stable period and over the age of 40,
* The absence of abnormal laboratory findings,
* Not having a mental problem that prevents filling the questionnaires to be used in the study, - The absence of any other respiratory disease such as asthma,
* Giving the informed consent.

Exclusion Criteria:

* COPD exacerbation (hospitalization with acute exacerbation in the last 15 days),
* Presence of cognitive impairment,
* Pregnancy status,
* Ischemic heart disease,
* Kyphoscoliosis and advanced postural disorder,
* Orthopedic problems and amputation surgery,
* Emphysema, bullous lung disease,
* Presence of bronchiectasis,
* Previous thoracic surgery history,
* Presence of lung cancer,
* Advanced heart failure.

Primary outcomes:
measure: Respiratory Muscle Strength
timeFrame: 10 minutes after obtaining socio-demographic information (It was done between the 10th and 20th minutes of the assessment).
measure: Peripheral Muscle Strength Assessment-Upper extremity
timeFrame: 25 minutes after obtaining socio-demographic information. After the respiratory muscle strength evaluation, the patients were rested for 5 minutes (It was done between the 25th and 35th minutes of the assessment).
measure: Peripheral Muscle Strength Assessment-Lower extremity
timeFrame: 40 minutes after obtaining socio-demographic information. After Upper extremity muscle strength evaluation patients were rested for five minutes (It was done between the 40th and 55th minutes of the assessment)
measure: Pulmonary Function Test (PFT) results
timeFrame: 55 minutes after obtaining socio-demographic information.
Secondary outcomes:
measure: Duration of the disease
timeFrame: After the permission of patients, in the first 10 minutes of assessment while obtaining socio-demographic information of patients.
measure: Exacerbation numbers in last one year
timeFrame: After the permission of patients, in the first 10 minutes of assessment while obtaining socio-demographic information of patients.
measure: Hospitalization numbers in last one year
timeFrame: After the permission of patients, in the first 10 minutes of assessment while obtaining socio-demographic information of patients.
Other outcomes:
Locations:
city: Istanbul
country: Turkey
facility: Marmara University
state: Maltepe
Study officials:
affiliation: Marmara University
name: Begum Unlu, PT, MSc
role: PRINCIPAL_INVESTIGATOR
References: