Clinical trial NCT02261909: New Prognostic Kidney Function Markers in Emergency Patients New Markers of Kidney Function in ED Patients
Official title: New Prognostic Kidney Function Markers in Emergency Patients
Study type: OBSERVATIONAL
Overall status: WITHDRAWN
Conditions: Acute Kidney Injury
Contrast Media
Keywords: Emergency Medicine
diagnosis
Lead sponsor: Krankenhaus Barmherzige Brüder, Regensburg
Sponsor class: OTHER
Collaborators: name: Astute Medical, Inc.
First posted: 2014-10-10
Enrollment: 0
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: CASE_CONTROL
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Patients in the in emergency department who have the indication for contrast enhanced CT and a predicted hospital admission time of 48 hours or longer.

Brief summary: NephroCheck is measuring the concentration of a certain protein combination in the urine of patients. In elevated values there is a probability of renal failure (already proven in intensive care patients). The investigators would like to investigate whether the investigators can predict renal failure in patients receiving contrast enhanced CT's in the emergency department. That would lead to an earlier nephrologist consult in those patients.

Detailed description: The use of contrast agents can - especially in already in impaired renal function - lead to a decline in real function. The contrast enhanced CT is especially in emergency patients an important diagnostic tool for example in the detection of pulmonary embolism or mesenteric ischemia. Creatinine has been used as a marker for real function so far. But the investigators all know that creatinine is not a perfect marker especially as it is influenced by age, sex, weight and muscle mass. Especially in the diagnosis of acute renal failure creatinine does not allow and recent change in the kidney function.

This prospective, unicentric study should therefore investigate two new markers in emergency patients who need an emergency contrast enhanced CT to early predict pending kidney function decline.

Eligibility criteria: Inclusion Criteria:

* patients in the emergency department who have the indication for contrast enhanced CT and a predicted hospital admission time of 48 hours or longer.

Exclusion Criteria:

* children, pregnant women
* dialysis
* patients with kidney transplants
* patients on steroids or further immunocompromised

Primary outcomes:
measure: Renal function
timeFrame: participants will be followed for the duration of hospital stay, an expected average of 7 days
Secondary outcomes:
measure: Requirement for dialysis
timeFrame: participants will be followed for the duration of hospital stay, an expected average of 7 days
measure: Admission to ICU
timeFrame: participants will be followed for the duration of hospital stay, an expected average of 7 days
Other outcomes:
Locations:
city: Regensburg
country: Germany
facility: Krankenhaus Barmherzige Brueder
state: Bavaria
Study officials:
affiliation: Krankenhaus Barmherzige Brüder
name: Jan Braess, Prof
role: STUDY_CHAIR
References:
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