Clinical trial NCT01688011: Connect® Myeloid Disease Registry
Official title: Connect® Myeloid: The Myelofibrosis (MF), Myelodysplastic Syndromes (MDS) and Acute Myeloid Leukemia (AML) Disease Registry
Study type: OBSERVATIONAL
Overall status: RECRUITING
Conditions: Primary Myelofibrosis
Myelodysplastic Syndromes
Leukemia, Myeloid, Acute
Keywords: Myelodysplastic syndromes
MDS
Acute myeloid leukemia
AML
Registry
Connect®
ICUS
Idiopathic Cytopenias of Undetermined Significance
Myelofibrosis
MF
Myelodysplastic/Myeloproliferative overlap syndromes
MDS/MPN overlap syndromes
Lead sponsor: Celgene
Sponsor class: INDUSTRY
First posted: 2012-09-19
Enrollment: 2300
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: OTHER
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Approximately 2,300 adult patients diagnosed with myeloid disease will be enrolled in Connect® Myeloid Registry from 200 sites (both community \[70-80%\] and academic \[20-30%\] facilities) across the US that are representative of where patients with myeloid diseases are diagnosed and treated.

Brief summary: The purpose of the Connect® Myeloid disease registry is to provide unique insights into treatment decisions and treatment patterns as they relate to clinical outcomes of patients with myeloid diseases in routine clinical practice. This disease registry will also evaluate molecular and cellular markers that may provide further prognostic classification which may or may not be predictive of therapy and clinical outcomes.

Detailed description: This Disease Registry will collect data on patient characteristics, treatment patterns and clinical outcomes. The objective is to describe how patients with myeloid diseases are treated; and to build a knowledge base regarding the effectiveness and safety of first line and subsequent treatment regimens in both community and academic settings. Enrolled patients will receive treatment and evaluations for their disease according to the standard of care and routine clinical practice at each study site. All treatments that patients receive for their disease will be recorded, including initial treatment and any subsequent therapy. Data on treatment outcomes, including response rates as measured by the treating physician, evidence of progression, survival, and patient-reported outcomes will be collected quarterly on the electronic CRF.

Eligibility criteria: Inclusion Criteria:

* Patients must be able to provide written informed consent form (ICF)
* Must be willing and able to complete baseline and follow-up HRQoL instruments, for which patients must be proficient in either English or Spanish
* AML patients must be at least 55 years of age at the time of informed consent.
* MF, ICUS, and MDS patients must be at least 18 years of age at the time of informed consent.

Newly diagnosed Idiopathic Cytopenias of Undetermined Significance (ICUS), Myelodysplastic Syndromes (MDS), Acute Myeloid Leukemia (AML) patients:

* Newly diagnosed primary or secondary disease. To be considered "newly diagnosed", a patient's confirmed diagnosis must be made no more than 60 days prior to the date of consent signature. (An additional 5-day window \[i.e., up to 65 days prior to the date of ICF signature\] may be allowed in special circumstance upon sponsor approval)
* Cohort assignment confirmed by central eligibility review. Cohort assignment must also be confirmed by the site.

Myelofibrosis (MF) patients:

* Patients who initiated their first active systemic treatment for MF and/or MF-related cytopenias within 90 days prior to the date of consent signature. This cohort allows the enrollment of subjects with a diagnosis of Myelodysplastic/Myeloproliferative overlap syndromes (MDS/MPN overlap syndrome).
* Cohort assignment is confirmed by the site. Central eligibility review is not required.

Treated Lower-Risk Myelodysplastic Syndromes (LR-MDS) patients:

* Patients who have initiated first active treatment regimen containing at least one non-ESA therapy, within 90 days prior to ICF
* Cohort assignment is confirmed by site. Central eligibility review is not required.

Luspatercept treated patients:

* Patient must have been at least 18 years of age at the start of luspatercept.
* Among LR-MDS patients, patient must have initiated luspatercept on or after September 1, 2023, must be ESA-naïve and luspatercept must be the first active treatment (as monotherapy or part of a treatment regimen) for their disease.
* Among all other myeloid malignancies, there is no date restriction for initiation of luspatercept .Patient may have received prior treatment for their disease.
* Patient must have at least 3 months of follow-up from start of luspatercept treatment at the participating site.

Exclusion Criteria:

* Suspected or proven acute promyelocytic leukemia (APL) (FAB M3 or WHO 2008) based on morphology, immunophenotype, molecular assay or karyotype
* Currently enrolled in any interventional clinical trial where the patient is being treated with an investigational product that cannot be identified.
* Idiopathic Cytopenias of Undetermined Significance (ICUS), Myelodysplastic Syndromes (MDS) patients who received or are receiving active (disease modifying) therapy for the treatment of MDS prior to the date of informed consent.
* Acute Myeloid Leukemia (AML) patients who initiated active (disease modifying treatment for AML more than 2 weeks prior to the date of consent.
* Myelofibrosis (MF) and Myelodysplastic/Myeloproliferative (MDS/MPN) overlap syndrome patients with suspected juvenile myelomonocytic leukemia (JMML).

Luspatercept treated patients:

* Patient must not be currently or previously enrolled in the Connect Myeloid Registry.
* Patient must not have received luspatercept as part of a clinical trial.

Primary outcomes:
measure: Patient Demographics- MDS/AML/ICUS Cohorts
timeFrame: Up to 8 years
measure: Diagnostic and Treatment Patterns- MDS/AML/ICUS Cohorts
timeFrame: Up to 8 years
measure: Safety and Effectiveness- MDS/AML/ICUS Cohorts
timeFrame: Up to 8 years
measure: Patient Demographics- MF Cohort
timeFrame: Up to 5 years
measure: Diagnostic and Treatment Patterns- MF Cohort
timeFrame: Up to 5 years
measure: Safety and Effectiveness- MF Cohort
timeFrame: Up to 5 years
measure: Treatment effectiveness - LTC
timeFrame: Minimum of 3-months post index date
measure: Treatment patterns and clinical outcomes - LTC Cohort
timeFrame: Minimum of 3-months post index date
measure: Transfusion information - LTC
timeFrame: Minimum of 3-months post index date
measure: Treatment duration - LTC Cohort
timeFrame: Minimum of 3-months post index date
Secondary outcomes:
measure: Patient Reported Outcome
timeFrame: Up to 8 years
measure: Correlative Studies
timeFrame: Up to 8 years
measure: Patient demographics and clinical characteristics - LTC
timeFrame: Baseline
measure: Reason for treatment discontinuation - LTC
timeFrame: Minimum of 3-months post index date
Other outcomes:
Locations:
city: Huntsville
country: United States
facility: ONCOLOGY SPECIALTIES, PC - Clearview Cancer Institute
state: Alabama
city: Tuscaloosa
country: United States
facility: DCH Health System (Lewis and Faye Manderson Cancer Center)
state: Alabama
city: Phoenix
country: United States
facility: Arizona Oncology
state: Arizona
city: Tucson
country: United States
facility: The University of Arizona Cancer Center
state: Arizona
city: Tucson
country: United States
facility: Local Institution - 1273
state: Arizona
city: Fayetteville
country: United States
facility: Highlands Oncology Group
state: Arkansas
city: Fort Smith
country: United States
facility: Mercy Hospital Fort Smith
state: Arkansas
city: Hot Springs
country: United States
facility: Genesis Cancer Center
state: Arkansas
city: Jonesboro
country: United States
facility: Clopton Clinic of Jonesboro, Inc.
state: Arkansas
city: Jonesboro
country: United States
facility: NEABC- Fowler Family Center for Cancer Care
state: Arkansas
city: Jonesboro
country: United States
facility: Local Institution - 1161
state: Arkansas
city: Little Rock
country: United States
facility: CARTI
state: Arkansas
city: Bakersfield
country: United States
facility: Comprehensive Blood & Cancer Center
state: California
city: Berkeley
country: United States
facility: Alta Bates Summit Comprehensive Cancer
state: California
city: Berkeley
country: United States
facility: Sutter East Bay Hospitals (dba Jordan Research and Education Institute - REDI)
state: California
city: Concord
country: United States
facility: John Muir Clinical Research Center
state: California
city: Fountain Valley
country: United States
facility: Robert A. Moss, M.D.,F AC.P, Inc
state: California
city: Fresno
country: United States
facility: VA Central California Health Care System
state: California
city: Greenbrae
country: United States
facility: Marin Cancer Care
state: California
city: La Jolla
country: United States
facility: UCSD Moores Cancer Center
state: California
city: Monterey
country: United States
facility: Pacific Cancer Care
state: California
city: Pleasanton
country: United States
facility: HealthCare Alliance (UHA)
state: California
city: Sacramento
country: United States
facility: Mercy Cancer Center
state: California
city: San Diego
country: United States
facility: Local Institution - 1016
state: California
city: Santa Rosa
country: United States
facility: Local Institution - 1027
state: California
city: Santa Rosa
country: United States
facility: St Joseph Heritage Healthcare
state: California
city: Stockton
country: United States
facility: St. Joseph's Regional Cancer Center
state: California
city: Thousand Oaks
country: United States
facility: Ashwin Kashyap MD, INC.
state: California
city: Denver
country: United States
facility: Saint Joseph Hospital, Cancer Centers of Colorado
state: Colorado
city: Manchester
country: United States
facility: Regional Cancer Care Associates
state: Connecticut
city: Stamford
country: United States
facility: Bennett Cancer Center Stamford Hospital
state: Connecticut
city: Christiana
country: United States
facility: Delaware Clinical and Laboratory Physicians
state: Delaware
city: Washington
country: United States
facility: MedStar Health Research Institute (Washington)
state: District of Columbia
city: Boynton Beach
country: United States
facility: University Cancer Institute
state: Florida
city: Daytona Beach
country: United States
facility: Halifax Health Center for Oncology
state: Florida
city: Fort Lauderdale
country: United States
facility: Broward Oncology Associates
state: Florida
city: Fort Lauderdale
country: United States
facility: Holy Cross Hospital
state: Florida
city: Fort Lauderdale
country: United States
facility: Southeast FL Hematology Oncology Grp
state: Florida
city: Fort Lauderdale
country: United States
facility: Broward Health Medical Center
state: Florida
city: Gainesville
country: United States
facility: University of Florida
state: Florida
city: Jacksonville
country: United States
facility: University of Florida College of Medicine
state: Florida
city: Jacksonville
country: United States
facility: Cancer Specialists of North Florida
state: Florida
city: Lakeland
country: United States
facility: Watson Clinic Center for Cancer Care and Research
state: Florida
city: Lecanto
country: United States
facility: Cancer and Blood Disease Center
state: Florida
city: Ocala
country: United States
facility: Ocala Oncology
state: Florida
city: Orange Park
country: United States
facility: 21st Century Oncology
state: Florida
city: Orlando
country: United States
facility: Adventist Health System/Sunbelt, Inc.
state: Florida
city: Pembroke Pines
country: United States
facility: Memorial Healthcare System
state: Florida
city: Pensacola
country: United States
facility: Sacred Heart Medical Oncology Group
state: Florida
city: Rockledge
country: United States
facility: Cancer Care Centers of Brevard
state: Florida
city: Tallahassee
country: United States
facility: Tallahassee Memorial Cancer Center
state: Florida
city: Titusville
country: United States
facility: Space Coast Medical Associates
state: Florida
city: Vero Beach
country: United States
facility: Indian River Memorial Hospital Scully Welsh Cancer Center
state: Florida
city: Winter Haven
country: United States
facility: Bond Clinic
state: Florida
city: Albany
country: United States
facility: Phoebe Putney Memorial Hospital
state: Georgia
city: Atlanta
country: United States
facility: Piedmont Cancer Institute, P.C. (was Peachtree Hematology-Oncology Consultants)
state: Georgia
city: Atlanta
country: United States
facility: Emory University
state: Georgia
city: Augusta
country: United States
facility: Georgia Regents University Cancer Center
state: Georgia
city: Brunswick
country: United States
facility: Southeast Georgia Health System
state: Georgia
city: Columbus
country: United States
facility: Columbus Regional Research Institute
state: Georgia
city: Marietta
country: United States
facility: Northwest Georgia Oncology Centers, P.C.
state: Georgia
city: Boise
country: United States
facility: Saint Alphonsus Regional Medical Center
state: Idaho
city: Chicago
country: United States
facility: Hektoen Inst for Medical Resrch on behalf of itself and John H Stroger Hosp
state: Illinois
city: Chicago
country: United States
facility: RUSH University Cancer Center
state: Illinois
city: Evanston
country: United States
facility: NorthShore University Health System
state: Illinois
city: Harvey
country: United States
facility: Ingalls Memorial Hospital
state: Illinois
city: Hinsdale
country: United States
facility: DuPage Medical Group - Oncology (University of Rodchester)
state: Illinois
city: Joliet
country: United States
facility: Joliet Oncology Hematology Associates Ltd
state: Illinois
city: Joliet
country: United States
facility: Local Institution - 1145
state: Illinois
city: Niles
country: United States
facility: Oncology Specialists, SC
state: Illinois
city: Peoria
country: United States
facility: Illinois Cancer Care
state: Illinois
city: Quincy
country: United States
facility: Quincy Medical Group
state: Illinois
city: Skokie
country: United States
facility: Edward H. KaPlan MD & Associates
state: Illinois
city: Skokie
country: United States
facility: Orchard Healthcare Research Inc.
state: Illinois
city: Springfield
country: United States
facility: Simmons Cancer Institute at Southern Illinois University
state: Illinois
city: Urbana
country: United States
facility: Carle Cancer Center
state: Illinois
city: Anderson
country: United States
facility: St. Vincent Anderson Regional Hospital Research
state: Indiana
city: Bloomington
country: United States
facility: IU health Bloomington Hospital
state: Indiana
city: Lafayette
country: United States
facility: Horizon Oncology Research, Inc
state: Indiana
city: New Albany
country: United States
facility: Floyd Memorial Cancer Center of Indiana
state: Indiana
city: Newburgh
country: United States
facility: Oncology Hematology Associates of Southwest Indiana
state: Indiana
city: South Bend
country: United States
facility: Northern Indiana Cancer Research Consortium
state: Indiana
city: Vincennes
country: United States
facility: Good Samaritan Hospital - Wabash Valley Clinical Research Center
state: Indiana
city: Ames
country: United States
facility: McFarland Clinic, P.C
state: Iowa
city: Sioux City
country: United States
facility: Siouxland Hematology-Oncology Associates
state: Iowa
city: Waterloo
country: United States
facility: Covenant Clinic
state: Iowa
city: Garden City
country: United States
facility: Central Care Cancer Center
state: Kansas
city: Topeka
country: United States
facility: Cotton O'Neil Clinical Research/ Stormont Vail Health
state: Kansas
city: Wichita
country: United States
facility: Cancer Center of Kansas
state: Kansas
city: Ashland
country: United States
facility: Ashland-Bellefonte Cancer Center
state: Kentucky
city: Lexington
country: United States
facility: Baptist Health Lexington
state: Kentucky
city: Louisville
country: United States
facility: Baptist Health Systems, Inc., DBA Baptist
state: Kentucky
city: Baton Rouge
country: United States
facility: Mary Bird Perkins Cancer Center (Baton Rouge)
state: Louisiana
city: Baton Rouge
country: United States
facility: Our Lady of the Lake Physician Group-Medical Oncology
state: Louisiana
city: Covington
country: United States
facility: Mary Bird Perkins Cancer Center at St. Tammany
state: Louisiana
city: Covington
country: United States
facility: QCCA - Pontchartrain Cancer Center
state: Louisiana
city: Lewiston
country: United States
facility: Maine Research Associates/Central Maine Medicine
state: Maine
city: Baltimore
country: United States
facility: Weinberg Cancer Institute at Franklin Square
state: Maryland
city: Bethesda
country: United States
facility: Center for Cancer and Blood Disorders
state: Maryland
city: Columbia
country: United States
facility: Maryland Oncology Hematology
state: Maryland
city: Cumberland
country: United States
facility: Western Maryland Health System
state: Maryland
city: Towson
country: United States
facility: UM St. Joseph's Medical Center
state: Maryland
city: Westminster
country: United States
facility: Carroll Regional Cancer Center
state: Maryland
city: Boston
country: United States
facility: Dana-Farber Cancer Institute
state: Massachusetts
city: Hyannis
country: United States
facility: Cape Cod Hospital
state: Massachusetts
city: Ann Arbor
country: United States
facility: University of Michigan Health System (UMHS) - University Hospital (University of Michigan Medical Ce
state: Michigan
city: Columbia
country: United States
facility: Boone Hospital Center
state: Michigan
city: Dearborn
country: United States
facility: Oakwood Healthcare Inc.
state: Michigan
city: Detroit
country: United States
facility: John D. Dingell VA Medical Center /Cynthia Marbury
state: Michigan
city: Detroit
country: United States
facility: Henry Ford Health System
state: Michigan
city: Farmington Hills
country: United States
facility: Detroit Clinical Research Center
state: Michigan
city: Flint
country: United States
facility: Genesys Hurley Cancer Institute
state: Michigan
city: Grand Rapids
country: United States
facility: Cancer and Hematology Centers of Western Michigan
state: Michigan
city: Grosse Pointe Woods
country: United States
facility: Ascension St. John Hospital_Hematology (was St. Johns Hospital and Hematology-Oncology Associates East PC )
state: Michigan
city: Kalamazoo
country: United States
facility: West Michigan Cancer Center
state: Michigan
city: Lansing
country: United States
facility: Michigan State University/Breslin Cancer Center
state: Michigan
city: Southfield
country: United States
facility: St. John Providence Hospital System
state: Michigan
city: Augusta
country: United States
facility: Togus Va Medical Center
state: Minnesota
city: Duluth
country: United States
facility: Essentia Health Oncology Clinical Trials
state: Minnesota
city: Edina
country: United States
facility: Southdale Cancer Clinic
state: Minnesota
city: Saint Louis Park
country: United States
facility: Metro MN CCOP/Park Nicollet Institute
state: Minnesota
city: Saint Louis Park
country: United States
facility: Metro MN CCOP/Park Nicollet Institute
state: Minnesota
city: Hattiesburg
country: United States
facility: Hattiesburg Clinic Hematology/Oncology
state: Mississippi
city: Bolivar
country: United States
facility: MCDA - Central Care Center
state: Missouri
city: Cape Girardeau
country: United States
facility: Southeast Cancer Center
state: Missouri
city: Columbia
country: United States
facility: Harry S Truman Memorial Veterans' Hospital
state: Missouri
city: Jefferson City
country: United States
facility: Columbia Comprehensive Cancer Care Clinic
state: Missouri
city: Joplin
country: United States
facility: Mercy Cancer Center - Joplin
state: Missouri
city: Kansas City
country: United States
facility: Kansas City Veterans Affairs Medical Center
state: Missouri
city: Kansas City
country: United States
facility: Research Medical Center
state: Missouri
city: Saint Joseph
country: United States
facility: Heartland Regional Medical Center (Heartland Health)
state: Missouri
city: Saint Louis
country: United States
facility: Local Institution - 1110
state: Missouri
city: Saint Louis
country: United States
facility: Missouri Baptist Medical Center
state: Missouri
city: Saint Louis
country: United States
facility: Mercy Cancer - St. Louis
state: Missouri
city: Springfield
country: United States
facility: Mercy Research - Springfield
state: Missouri
city: Billings
country: United States
facility: Billings Clinic
state: Montana
city: Billings
country: United States
facility: St. Vincent Frontier Cancer Center
state: Montana
city: Missoula
country: United States
facility: Montana Cancer Institute Foundation
state: Montana
city: Lincoln
country: United States
facility: Southeast Nebraska Cancer Center
state: Nebraska
city: Las Vegas
country: United States
facility: Southern Nevada Cancer Research Foundation
state: Nevada
city: Reno
country: United States
facility: Renown Regional Medical Center
state: Nevada
city: Manchester
country: United States
facility: VA Medical Center Manchester
state: New Hampshire
city: Englewood
country: United States
facility: Englewood Hospital and Medical Center
state: New Jersey
city: Hackensack
country: United States
facility: John Theurer Cancer Center (Hackensack U Med Center)
state: New Jersey
city: Morristown
country: United States
facility: Hematology-Oncology Associates of Northern New Jersey
state: New Jersey
city: New Brunswick
country: United States
facility: Saint Peter's University Hospital
state: New Jersey
city: Paterson
country: United States
facility: St Joseph Healthcare System
state: New Jersey
city: Somerville
country: United States
facility: Somerset Medical Center 110 Rehill Avenue
state: New Jersey
city: Sparta
country: United States
facility: Sparta Cancer Center
state: New Jersey
city: Bronx
country: United States
facility: Albert Einstein College of Medicine - Montefiore Medical Center
state: New York
city: Bronx
country: United States
facility: New York Cancer and Blood Specialists
state: New York
city: Brooklyn
country: United States
facility: Maimonides Cancer Center
state: New York
city: Cooperstown
country: United States
facility: Bassett Heathcare Network
state: New York
city: East Syracuse
country: United States
facility: Hematology Oncology Associates of Central NY
state: New York
city: Glens Falls
country: United States
facility: C.R. Wood Cancer Center at Glens Falls Hospital
state: New York
city: Huntington Station
country: United States
facility: Huntington Medical Group
state: New York
city: Johnson City
country: United States
facility: Local Institution - 1047
state: New York
city: New York
country: United States
facility: Weill Cornell Medical College
state: New York
city: Rochester
country: United States
facility: Rochester General Hospital
state: New York
city: Rochester
country: United States
facility: University of Rochester ~ Wilmot Cancer Institute
state: New York
city: Roslyn
country: United States
facility: St. Francis Hospital
state: New York
city: Valhalla
country: United States
facility: New York Medical College
state: New York
city: Williamsville
country: United States
facility: Ccs Oncology
state: New York
city: Greenville
country: United States
facility: Leo W Jenkins Cancer Center
state: North Carolina
city: Kinston
country: United States
facility: Kinston Medical Specialists
state: North Carolina
city: Winston-Salem
country: United States
facility: Wake Forest Baptist Health
state: North Carolina
city: Akron
country: United States
facility: Summa Health System
state: Ohio
city: Canton
country: United States
facility: Gabrail Cancer Center Research
state: Ohio
city: Cincinnati
country: United States
facility: TriHealth, Good Samaritan Hospital
state: Ohio
city: Cleveland
country: United States
facility: University Hospitals, Case Medical Center
state: Ohio
city: Cleveland
country: United States
facility: Cleveland Clinic Foundation
state: Ohio
city: Cleveland
country: United States
facility: Local Institution - 1088
state: Ohio
city: Columbus
country: United States
facility: Mid Ohio Oncology/Hematology, Inc., dba The Mark H. Zangmeister Center
state: Ohio
city: Kettering
country: United States
facility: Dayton Physicians
state: Ohio
city: Toledo
country: United States
facility: University of Toledo Medical Center (Utmc)
state: Ohio
city: Oklahoma City
country: United States
facility: INTEGRIS Cancer Institute Southwest Medical Center
state: Oklahoma
city: Oklahoma City
country: United States
facility: INTEGRIS Cancer Institute of Oklahoma Proton Campus
state: Oklahoma
city: Tulsa
country: United States
facility: Oklahoma Cancer Specialist and Research Institute
state: Oklahoma
city: Corvallis
country: United States
facility: Good Samaritan Hospital Corvallis
state: Oregon
city: Portland
country: United States
facility: Local Institution - 1131
state: Oregon
city: Portland
country: United States
facility: Providence Cancer Center
state: Oregon
city: Salem
country: United States
facility: Salem Health
state: Oregon
city: Drexel Hill
country: United States
facility: Consultants in Medical Oncology and Hematology
state: Pennsylvania
city: Dunmore
country: United States
facility: Hematology and Oncology Assoc of NEPA
state: Pennsylvania
city: Lancaster
country: United States
facility: Lancaster Cancer Center
state: Pennsylvania
city: Lancaster
country: United States
facility: Lancaster General Hospital
state: Pennsylvania
city: Pittsburgh
country: United States
facility: Allegheny Singer Research Institute (was West Penn Hospital)
state: Pennsylvania
city: Pittsburgh
country: United States
facility: University of Pittsburgh Cancer Institute
state: Pennsylvania
city: West Reading
country: United States
facility: Reading Hospital - McGlinn Cancer Institute
state: Pennsylvania
city: York
country: United States
facility: Cancer Care Associates of York
state: Pennsylvania
city: Providence
country: United States
facility: Roger Williams Medical Center
state: Rhode Island
city: Charleston
country: United States
facility: Charleston Hematology Oncology Associates, PA
state: South Carolina
city: Greenville
country: United States
facility: Prisma Health Cancer Institute - Upstate
state: South Carolina
city: Spartanburg
country: United States
facility: Spartanburg Regional Medical Center
state: South Carolina
city: Watertown
country: United States
facility: Prairie Lakes Health Systen, Inc
state: South Dakota
city: Knoxville
country: United States
facility: Thompson Cancer Survival Center
state: Tennessee
city: Knoxville
country: United States
facility: University of Tennessee Medical Center Cancer Intitute
state: Tennessee
city: Memphis
country: United States
facility: Regional One Health
state: Tennessee
city: Nashville
country: United States
facility: Vanderbilt-Ingram Cancer Center
state: Tennessee
city: Abilene
country: United States
facility: Hendrick Cancer Center
state: Texas
city: Amarillo
country: United States
facility: BSL Health System (Harrington Cancer Center)
state: Texas
city: Amarillo
country: United States
facility: Texas Oncology, Amarillo Cancer Center
state: Texas
city: Corpus Christi
country: United States
facility: Coastal Bend Cancer Center
state: Texas
city: Corpus Christi
country: United States
facility: Christus Spohn Cancer Center
state: Texas
city: Dallas
country: United States
facility: Dallas VA Medical Center
state: Texas
city: Dallas
country: United States
facility: HOLD - Texas Oncology, Dallas
state: Texas
city: Dallas
country: United States
facility: Texas Oncology - Sammons Cancer Center
state: Texas
city: Fort Worth
country: United States
facility: Texas Oncology - Fort Worth Cancer Center
state: Texas
city: Galveston
country: United States
facility: UTMB Galveston
state: Texas
city: Laredo
country: United States
facility: Oncology and Hematology of South Texas, PA
state: Texas
city: Lubbock
country: United States
facility: Southwest Cancer Treatment & Research Center
state: Texas
city: McAllen
country: United States
facility: Texas Oncology, McAllen (plus 2 satelite sites)
state: Texas
city: Midland
country: United States
facility: Texas Oncology, Midland
state: Texas
city: Round Rock
country: United States
facility: Scott & White Healthcare
state: Texas
city: Temple
country: United States
facility: Baylor Research Institute dba Scott & White Memorial Hospital
state: Texas
city: Tyler
country: United States
facility: Blood and cancer Center of East Texas
state: Texas
city: Ogden
country: United States
facility: Community Cancer Trials of Utah
state: Utah
city: Rutland
country: United States
facility: Foley Cancer Center/RRMC
state: Vermont
city: White River Junction
country: United States
facility: VA Medical Center - White River Junction
state: Vermont
city: Lynchburg
country: United States
facility: Lynchburg Hematology Oncology Clinic
state: Virginia
city: Newport News
country: United States
facility: Peninsula Cancer Institute
state: Virginia
city: Bellingham
country: United States
facility: PeaceHealth St Joseph Cancer Center
state: Washington
city: Everett
country: United States
facility: Providence Regional Cancer Partnership
state: Washington
city: Kennewick
country: United States
facility: Kadlec Regional Medical Center (KRMC)
state: Washington
city: Olympia
country: United States
facility: Vista Oncology Inc. PS
state: Washington
city: Seattle
country: United States
facility: Benaroya Research Institute at Virginia Mason
state: Washington
city: Seattle
country: United States
facility: Swedish Cancer Institute
state: Washington
city: Walla Walla
country: United States
facility: Providence St. Mary Regional Cancer Center
state: Washington
city: Morgantown
country: United States
facility: West Virginia University
state: West Virginia
city: Green Bay
country: United States
facility: St. Vincent Hospital
state: Wisconsin
city: Green Bay
country: United States
facility: Bellin Memorial Hospital/ Bellin Cancer Team
state: Wisconsin
city: La Crosse
country: United States
facility: Gundersen Lutheran Inc
state: Wisconsin
city: Milwaukee
country: United States
facility: Froedtert & Medical College of Wisconsin CLCC
state: Wisconsin
city: Milwaukee
country: United States
facility: Columbia St. Mary'S
state: Wisconsin
city: Racine
country: United States
facility: Wheaton Franciscan Cancer Care - All Saints
state: Wisconsin
city: Waukesha
country: United States
facility: Waukesha Memorial Hospital
state: Wisconsin
city: Cheyenne
country: United States
facility: Memorial Hospital of Laramie County dba Cheyenne Regional Medical Center
state: Wyoming
city: Bayamon
country: Puerto Rico
facility: Puerto Rico Hematology Oncology Group
city: San Juan
country: Puerto Rico
facility: VA Caribbean Healthcare System CRADA
city: San Juan
country: Puerto Rico
facility: Fundacion de lnvestigaci6n
Study officials:
affiliation: Bristol-Myers Squibb
name: Bristol-Myers Squibb
role: STUDY_DIRECTOR
References:
citation: Steensma DP, Abedi M, Bejar R, Cogle CR, Foucar K, Garcia-Manero G, George TI, Grinblatt D, Komrokji R, Ma X, Maciejewski J, Pollyea DA, Savona MR, Scott B, Sekeres MA, Thompson MA, Swern AS, Nifenecker M, Sugrue MM, Erba H. Connect MDS/AML: design of the myelodysplastic syndromes and acute myeloid leukemia disease registry, a prospective observational cohort study. BMC Cancer. 2016 Aug 19;16:652. doi: 10.1186/s12885-016-2710-6.