Clinical trial NCT05022992: Effects of a Single Bout of Resistance Training Session on Hormonal Response in Pre-pubertal and Pubertal Boys
Official title: Effects of a Single Bout of Resistance Training Session on Hormonal Response in Pre-pubertal and Pubertal Boys
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Hormones
Cytokines
Lead sponsor: Umeå University
Sponsor class: OTHER
First posted: 2021-08-26
Enrollment: 40
Sex: MALE
Minimum age (years): 9
Maximum age (years): 17
Standard ages: CHILD
Accepts healthy volunteers: yes
Allocation: NON_RANDOMIZED
Intervention model: PARALLEL
Primary purpose: OTHER

Brief summary: : Resistance training induces strength gains in both children and adolescents. Exercise training is linked to anabolic functions through the GH-IGF-I axis. This has been demonstrated in studies showing a higher activity of GH and IGF-I in fitter adolescents and adults. Exercise also stimulates pro-inflammatory cytokines (IL-1β, IL-6, TNF-α) that suppress the GH-IGF-I axis. This has been observed in endurance-type training, while resistance training has received less attention.

Boys experience a significant physiological muscle-growth change during puberty that is associated with increases in boys androgen levels. How maturation affects the hormonal response to resistance training in boys is unclear. Therefore, the purpose of the study is to compare the acute effects of a single bout of resistance training on hormones and pro-inflammatory cytokines in pre-pubertal and pubertal boys.

Detailed description: Preliminary measurements:

Preliminary testing will include anthropometric measurements of body mass, height, body fat percentage, and lean leg volume (LLV). The maturation stage will be determined according to the Tanner scale. There will also be an assessment of maximal strength testing to determine exercise intensity for each individual. Two familiarization sessions will be conducted for muscular strength before the muscular strength testing session.

Main trial A venous blood sample will be collected pre-exercise at resting condition. The trial will start with a standardized warm-up followed by a short (20-30 min), high-intensity whole-body resistance training session. Venous blood samples will be collected immediately after the completion of the training session and during the recovery period.

Eligibility criteria: Inclusion Criteria:

* Healthy boys (n=40)
* Physically active, defined as a minimum of 2 years experience in a sports club
* Biological age range: 20 pre-pubertal (Tanner I-II) - 20 pubertal (Tanner III-IV) boys
* No previous experience of structured resistance training

Exclusion Criteria:

* Chronic diseases that affect full participation
* Injuries that limit full participation

Primary outcomes:
measure: Growth Hormone Baseline
timeFrame: Baseline testing before the exercise intervention (Pre values)
measure: Change from Baseline Growth Hormone Post exercise
timeFrame: Right after the completion of the exercise intervention (Post values)
measure: Change from Baseline Growth Hormone 15 minutes post exercise
timeFrame: 15 minutes after the completion of the exercise intervention (Post-15 values)
measure: Change from Baseline Growth Hormone 30 minutes post exercise
timeFrame: 30 minutes after the completion of the exercise intervention (Post-30 values)
measure: Insulin-like Growth Factor-1 Baseline
timeFrame: Baseline testing before the exercise intervention (Pre values)
measure: Change from Baseline Insulin-like Growth Factor-1 Post exercise
timeFrame: Right after the completion of the exercise intervention (Post values)
measure: Change from Baseline Insulin-like Growth Factor-1 15 minutes Post exercise
timeFrame: 15 minutes after the completion of the exercise intervention (Post-15 values)
measure: Change from Baseline Insulin-like Growth Factor-1 30 minutes Post exercise
timeFrame: 30 minutes after the completion of the exercise intervention (Post-30 values)
Secondary outcomes:
measure: Cortisol Baseline
timeFrame: Baseline testing before the exercise intervention (Pre values)
measure: Change from Baseline Cortisol Post exercise
timeFrame: Right after the completion of the exercise intervention (Post values)
measure: Change from Baseline Cortisol 15 minutes Post exercise
timeFrame: 15 minutes after the completion of the exercise intervention (Post-15 values)
measure: Change from Baseline Cortisol 30 minutes Post exercise
timeFrame: 30 minutes after the completion of the exercise intervention (Post-30 values)
measure: Testosterone Baseline
timeFrame: Baseline testing before the exercise intervention (Pre values)
measure: Change from Baseline Testosterone Post Exercise
timeFrame: Right after the completion of the exercise intervention (Post values)
measure: Change from Baseline Testosterone 15 minutes Post Exercise
timeFrame: 15 minutes after the completion of the exercise intervention (Post-15 values)
measure: Change from Baseline Testosterone 30 minutes Post Exercise
timeFrame: 30 minutes after the completion of the exercise intervention (Post-30 values)
measure: Interleukin-6 Baseline
timeFrame: Baseline testing before the exercise intervention (Pre values)
measure: Change from Baseline Interleukin-6 Post Exercise
timeFrame: Right after the completion of the exercise intervention (Post values)
measure: Change from Baseline Interleukin-6 15 minutes Post Exercise
timeFrame: 15 minutes after the completion of the exercise intervention (Post-15 values)
measure: Change from Baseline Interleukin-6 30 minutes Post Exercise
timeFrame: 30 minutes after the completion of the exercise intervention (Post-30 values)
measure: Interleukin-1 alpha Baseline
timeFrame: Baseline testing before the exercise intervention (Pre values)
measure: Change from Baseline Interleukin-1 alpha Post Exercise
timeFrame: Right after the completion of the exercise intervention (Post values)
measure: Change from Baseline Interleukin-1 alpha 15 minutes Post Exercise
timeFrame: 15 minutes after the completion of the exercise intervention (Post-15 values)
measure: Change from Baseline Interleukin-1 alpha 30 minutes Post Exercise
timeFrame: 30 minutes after the completion of the exercise intervention (Post-30 values)
measure: Tumor Necrosis Factor alpha Baseline
timeFrame: Baseline testing before the exercise intervention (Pre values)
measure: Change from Baseline Tumor Necrosis Factor alpha Post Exercise
timeFrame: Right after the completion of the exercise intervention (Post values)
measure: Change from Baseline Tumor Necrosis Factor alpha 15 minutes Post Exercise
timeFrame: 15 minutes after the completion of the exercise intervention (Post-15 values)
measure: Change from Baseline Tumor Necrosis Factor alpha 30 minutes Post Exercise
timeFrame: 30 minutes after the completion of the exercise intervention (Post-30 values)
measure: Sex Hormone Binding Globulin Baseline
timeFrame: Baseline testing before the exercise intervention (Pre values)
measure: Change from Baseline Baseline Sex Hormone Binding Post Exercise
timeFrame: Right after the completion of the exercise intervention (Post values)
measure: Change from Baseline Baseline Sex Hormone Binding 15 minutes Post Exercise
timeFrame: 15 minutes after the completion of the exercise intervention (Post-15 values)
measure: Change from Baseline Sex Hormone Binding Globulin 30 minutes Post Exercise
timeFrame: 30 minutes after the completion of the exercise intervention (Post-30 values)
Other outcomes:
Locations:
city: Umeå
country: Sweden
facility: Umeå Movement and Exercise Laboratory, Umeå University
state: Västerbotten
Study officials:
affiliation: Umeå University
name: Apostolos Theos, PhD
role: PRINCIPAL_INVESTIGATOR
References: