Clinical trial NCT00553241: Short-Term Prognosis Evaluation of Transient Ischemic Attack Patients Using ABCD2 Score
Official title: Phase 1 of Clinical Trial of Risk Factor, Prognosis, Imaging and Standard Management of Transient Ischemic Attack.
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Ischemic Attack, Transient
Keywords: TIA
prognosis
evaluation
management
Lead sponsor: Capital Medical University
Sponsor class: OTHER
Collaborators: name: Beijing Anzhen Hospital
First posted: 2007-11-04
Enrollment: 1
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: patients diagnosed with transient will be enrolled in this study

Brief summary: The purpose of this study is to determine whether the ABCD2 score can be used in patients with transient ischemic attack, admitted to Beijing anzhen hospital, to evaluate the prognosis, risk factor of those patients.

Detailed description: The feasibility of risk stratification of patients with acute transient ischemic attack admitted to Beijing anzhen hospital by the ABCD2 score system is yet to be determined. The aim of this paper was to evaluate and validate the short-term prognosis of TIA patients in Peking area using this new score system.

Eligibility criteria: Inclusion Criteria:

* Every patient admitted to Beijing anzhen hospital with transient ischemic attack will be enrolled in this study, from 06/2007 to 12/2008. duration of the symptom not larger than 1 hour.
* Magnetic resonance imaging negative on DWI(no fresh infarction).
* Old infarction or not the criminal infarction.

Exclusion Criteria:

* Patients with hemorrhage stroke were excluded.

Primary outcomes:
measure: end points are defined as follow: transient ischemic attack, stroke, angina, myocardial infraction, peripheral vascular disease, intracerebral hemorrhage and other vascular death.
timeFrame: two year
Secondary outcomes:
Other outcomes:
Locations:
city: Beijing
country: China
facility: Dept. of Neurology, Beijing Anzhen Hospital, Capital Medical University
Study officials:
affiliation: Dept. of Neurology, Beijing Anzhen Hospital, Capital Medical University
name: Qi Bi
role: STUDY_CHAIR
References:
citation: Prabhakaran S, Chong JY, Sacco RL. Impact of abnormal diffusion-weighted imaging results on short-term outcome following transient ischemic attack. Arch Neurol. 2007 Aug;64(8):1105-9. doi: 10.1001/archneur.64.8.1105.
citation: Johnston SC, Gress DR, Browner WS, Sidney S. Short-term prognosis after emergency department diagnosis of TIA. JAMA. 2000 Dec 13;284(22):2901-6. doi: 10.1001/jama.284.22.2901.
citation: Weisberg LA. Clinical characteristics of transient ischemic attacks in black patients. Neurology. 1991 Sep;41(9):1410-4. doi: 10.1212/wnl.41.9.1410.
citation: Albers GW, Caplan LR, Easton JD, Fayad PB, Mohr JP, Saver JL, Sherman DG; TIA Working Group. Transient ischemic attack--proposal for a new definition. N Engl J Med. 2002 Nov 21;347(21):1713-6. doi: 10.1056/NEJMsb020987. No abstract available.
citation: Coull AJ, Lovett JK, Rothwell PM; Oxford Vascular Study. Population based study of early risk of stroke after transient ischaemic attack or minor stroke: implications for public education and organisation of services. BMJ. 2004 Feb 7;328(7435):326. doi: 10.1136/bmj.37991.635266.44. Epub 2004 Jan 26.
citation: Correia M, Silva MR, Magalhaes R, Guimaraes L, Silva MC. Transient ischemic attacks in rural and urban northern Portugal: incidence and short-term prognosis. Stroke. 2006 Jan;37(1):50-5. doi: 10.1161/01.STR.0000195209.26543.8f. Epub 2005 Dec 1.
citation: Clark TG, Murphy MF, Rothwell PM. Long term risks of stroke, myocardial infarction, and vascular death in "low risk" patients with a non-recent transient ischaemic attack. J Neurol Neurosurg Psychiatry. 2003 May;74(5):577-80. doi: 10.1136/jnnp.74.5.577.
citation: Giles MF, Flossman E, Rothwell PM. Patient behavior immediately after transient ischemic attack according to clinical characteristics, perception of the event, and predicted risk of stroke. Stroke. 2006 May;37(5):1254-60. doi: 10.1161/01.STR.0000217388.57851.62. Epub 2006 Mar 30.
citation: Sylaja PN, Coutts SB, Subramaniam S, Hill MD, Eliasziw M, Demchuk AM; VISION Study Group. Acute ischemic lesions of varying ages predict risk of ischemic events in stroke/TIA patients. Neurology. 2007 Feb 6;68(6):415-9. doi: 10.1212/01.wnl.0000252938.76188.52.
citation: Johnston SC, Rothwell PM, Nguyen-Huynh MN, Giles MF, Elkins JS, Bernstein AL, Sidney S. Validation and refinement of scores to predict very early stroke risk after transient ischaemic attack. Lancet. 2007 Jan 27;369(9558):283-92. doi: 10.1016/S0140-6736(07)60150-0.
citation: Tsivgoulis G, Spengos K, Manta P, Karandreas N, Zambelis T, Zakopoulos N, Vassilopoulos D. Validation of the ABCD score in identifying individuals at high early risk of stroke after a transient ischemic attack: a hospital-based case series study. Stroke. 2006 Dec;37(12):2892-7. doi: 10.1161/01.STR.0000249007.12256.4a. Epub 2006 Oct 19.
citation: Rothwell PM, Giles MF, Flossmann E, Lovelock CE, Redgrave JN, Warlow CP, Mehta Z. A simple score (ABCD) to identify individuals at high early risk of stroke after transient ischaemic attack. Lancet. 2005 Jul 2-8;366(9479):29-36. doi: 10.1016/S0140-6736(05)66702-5.
citation: Bray JE, Coughlan K, Bladin C. Can the ABCD Score be dichotomised to identify high-risk patients with transient ischaemic attack in the emergency department? Emerg Med J. 2007 Feb;24(2):92-5. doi: 10.1136/emj.2006.041624.