Clinical trial NCT00674180: Data Analysis of a Managed Care Weight Reduction Trial
Official title: Data Analysis of a Managed Care Weight Reduction Trial
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Overweight
Obesity
Lead sponsor: Albert Einstein College of Medicine
Sponsor class: OTHER
First posted: 2008-05-07
Enrollment: 588
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: OTHER
Time perspective: OTHER
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Participants were recruited from an HMO's patient population and from New Hyde Park, NY.

Brief summary: This study will involve secondary data analysis for a study done by Wylie-Rosett et al. in 2001 that evaluated the costs and effects of incremental components of a weight-loss program. Data analysis will involve cross-sectional and predictive analyses and may include: regression analyses to determine predictors of weight loss and cardiovascular risk, correlations between weight reduction strategies and biological indices, and interactions between biomarkers of inflammation and traditional cardiovascular risk factors. This data will also be available for economic modeling.

Detailed description: This study will involve secondary data analysis for a study done by Wylie-Rosett et al. in 2001. Using a 3-arm, 12-month randomized clinical trial, Wylie-Rosett et al. evaluated the costs and effects of incremental components of a weight-loss program. The study included 588 individuals (BMI\> 25 kg/m2) in a freestanding health maintenance organization and achieved an 81% completion rate. The intervention used a cognitive behavioral approach for tailoring lifestyle modification goals. The incremental levels of interventions included a) a workbook alone, b) the addition of computerized tailoring using onsite computer kiosks with touch screen monitors, and c) the addition of both computers and staff consultations. For the increasing levels of intervention intensity, the mean 12-month weight losses were 2.2, 4.7, and 7.4 pounds, with the respective cost per participant being $12.33, $41.99, and $133.74. The decreases in mean BMIs for these respective intervention levels were 0.4, 0.9, and 1.2. All groups reported a decrease in energy and fat intake and an increase in blocks walked (p\<.01). Intervention variables that correlated with weight loss included more computer logons, achieving computer-selected goals, more self-monitoring, increased walking, and decreased energy and fat intake, as well as higher attendance in staff consultation group sessions for that treatment condition. Weight loss correlated with decreases in fasting glucose and blood pressure. Wylie-Rosett et al. (2001) concluded that, in a weight-loss program, computers can facilitate selecting behavioral change goals. More frequent usage resulted in greater weight loss, and staff counseling to augment the computer intervention achieved the most weight loss. The purpose of this study will be secondary analysis of the data collected in the original MODELS study.

Eligibility criteria: Inclusion Criteria:

* BMI of more than 25 (or a BMI of 24 or more plus 1 cardiovascular risk factor), and the willingness to follow the study protocol, which included a refundable $100 deposit

Exclusion Criteria:

* Intention to move beyond commuting distance in the next 12 months,
* Medical conditions that would interfere with study participation,
* Unwillingness to follow the study protocol.

Primary outcomes:
measure: weight loss
timeFrame: 1 year
Secondary outcomes:
measure: diabetes and cardiovascular risk
timeFrame: 1 year
Other outcomes:
Locations:
Study officials:
affiliation: Albert Einstein College of Medicine
name: Judith Wylie-Rosett, EdD
role: PRINCIPAL_INVESTIGATOR
affiliation: Yeshiva University
name: Charles Swencionis, PhD
role: STUDY_CHAIR
References:
citation: Wylie-Rosett J, Swencionis C, Ginsberg M, Cimino C, Wassertheil-Smoller S, Caban A, Segal-Isaacson CJ, Martin T, Lewis J. Computerized weight loss intervention optimizes staff time: the clinical and cost results of a controlled clinical trial conducted in a managed care setting. J Am Diet Assoc. 2001 Oct;101(10):1155-62; quiz 1163-4. doi: 10.1016/s0002-8223(01)00284-x.
citation: Swencionis C, Wylie-Rosett J, Lent MR, Ginsberg M, Cimino C, Wassertheil-Smoller S, Caban A, Segal-Isaacson CJ. Weight change, psychological well-being, and vitality in adults participating in a cognitive-behavioral weight loss program. Health Psychol. 2013 Apr;32(4):439-46. doi: 10.1037/a0029186. Epub 2012 Aug 13.