Clinical trial NCT06325085: Compensatory and Restorative Rehabilitation Techniques in Stroke
Official title: Combined Effects of Restorative and Compensatory Rehabilitation Techniques on Executive Functions in Stroke With Mild Cognitive Impairment
Study type: INTERVENTIONAL
Overall status: RECRUITING
Phase: NA
Conditions: Cognitive Impairment
Keywords: Compensatory rehabilitation
Restorative Rehabilitation
Cognition
Stroke
Executive Functioning
Lead sponsor: Riphah International University
Sponsor class: OTHER
First posted: 2024-03-22
Enrollment: 36
Sex: ALL
Minimum age (years): 50
Maximum age (years): 70
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The aim of this randomized controlled trial is to find the combined effects of restorative and compensatory cognitive rehabilitation techniques in mild cognitive impairment after stroke.

Detailed description: Stroke is a prevalent medical neurological condition that often results in cognitive impairments, particularly in the domain of executive functions. Cognitive impairment has a significant impact on executive function in stroke subjects. Cognitive impairment on the stroke survivor exist on any single domain such as attention, spatial ability, language and executive ability more frequently than the multiple domains.

Cognitive training has been shown to be beneficial for rehabilitation of patients with cognitive impairment, but the underlying mechanisms remain unclear.

The combination of restorative and compensatory rehabilitation techniques is beneficial for gaining control over cognitive rehabilitation techniques will improve executive functions. The retention effects evaluated additionally will add a broad insight in this regard. It will improve the learning power of brain through neural plasticity. This leads to restoration of everyday functioning. This study aims to investigate the effects of two distinct rehabilitation approaches on the executive functions of stroke survivors with MCI. Understanding how these rehabilitation strategies impact cognitive recovery is essential for individuals living with post-stroke cognitive impairments.

Eligibility criteria: Inclusion Criteria:

* Age between 50 and 70 years
* Both Genders
* Individuals diagnosed with stroke 6 months before enrollment
* Minimum 6 years of schooling
* Patients with mild cognitive impairment (score 18-25 on MOCA)
* Individuals able to maintain sitting and standing balance (score 41 on berg balance scale)

Exclusion Criteria:

* \>10 on post stroke depression rating scale (PSDRS)
* Spasticity (\>3 on Ashworth scale)
* Other psychological disorders
* Patients diagnosed with Alzheimer's and dementia

Primary outcomes:
measure: Montreal cognitive assessment test (Urdu version)
timeFrame: 6 weeks
measure: Cognitive assessment scale for stroke patients (CASP)
timeFrame: 6 weeks
Secondary outcomes:
measure: Stroke specific quality of life questionnaire (Urdu version)
timeFrame: 6 weeks
measure: Modified Rankin Scale (MRS)
timeFrame: 6 weeks
Other outcomes:
Locations:
city: Dina
country: Pakistan
facility: Shafi Hospital Dina
state: Punjab
Study officials:
affiliation: Riphah International University
name: Aroosa Tariq, MS-NMPT
role: PRINCIPAL_INVESTIGATOR
References: