Clinical trial NCT05170178: Cracking the Code of Crying Babies: How Familiarity Changes the Interpretation of Cries
Official title: Cracking the Code of Crying Babies: How Familiarity Changes the Interpretation of Cries
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Magnetic Resonance Imaging
Neuronal Activity
Keywords: baby cries
pain
brain responses
fmRI
familiarity
Lead sponsor: Centre Hospitalier Universitaire de Saint Etienne
Sponsor class: OTHER
First posted: 2021-12-27
Enrollment: 62
Sex: ALL
Minimum age (years): 18
Maximum age (years): 50
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: NON_RANDOMIZED
Intervention model: PARALLEL
Intervention model description: Group with parental experience caring for infants (20 men and 20 women) Group with professional experience in caring for infants (20 women)
Primary purpose: BASIC_SCIENCE

Brief summary: Understanding babies' signals is essential to meet their needs. Recent works suggest that crying provides useful information, not only allowing parents to recognize their baby among others (static information), but also to distinguish between mild discomfort and pain cries (dynamic information). The perception of this information by adults involves a "parental" brain network including brain areas involved in empathy, attention, emotional regulation, motor as well as regions of the limbic system or associated with the reward network.

Detailed description: This network is involved when listening to cries of familiar babies, or pain cries. How do we become specialist of a baby's cries? To date, no functional imaging study has examined the specific brain activations when listening to the cries of a familiar baby in different situations, particularly painful ones.

Eligibility criteria: Inclusion Criteria

For all volunteers:

* Affiliated or entitled to a social security plan
* Right-handed by the Edinburgh laterality test
* Having given free, informed and written consent to participate in the study
* Having given their consent for the communication of the MRI results to their attending physician

Group with parental experience caring for infants :

* Men or women between 18 and 50 years old
* Parent of a child under 2 years old

Group with professional experience in caring for infants

* Women between 18 and 50 years old
* Without dependent children under 2 years of age
* People in daily contact with infants in the professional circle (e.g. nurses, pediatricians, midwives, maternity nurses, etc)

Exclusion Criteria

* Pregnant women, parturient, nursing mothers or parents
* Persons deprived of liberty, hospitalized without consent, hospitalized for purposes other than research
* Minors
* Adults under legal protection (guardianship) or unable to express their consent
* Subjects with contraindications to the MRI examination: use of a pacemaker or an insulin pump, wearing a metallic prothesis, an intracerebral clip or a piercing, claustrophobia,
* Taking medication for less than 12 hours,
* Neurological, psychiatric or auditory history or deficits.
* Anxiety and/or depressive disorders

Primary outcomes:
measure: BOLD signal (blood oxygen level-dependent)
timeFrame: during the whole listening session
Secondary outcomes:
measure: participants'experience at caring for babies
timeFrame: At the inclusion visit
measure: participants' sex
timeFrame: At the inclusion visit
Other outcomes:
Locations:
city: Bron
country: France
facility: HCL
city: Saint-etienne
country: France
facility: Chu Saint-Etienne
Study officials:
affiliation: Centre Hospitalier Universitaire de Saint Etienne
name: Roland PEYRON, MD
role: PRINCIPAL_INVESTIGATOR
References: