louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT05194488: Evolving Treatment Modalities for Management of Patients Suffering From Disc Displacement With Reduction
Official title: Evolving Treatment Modalities for Management of Patients Suffering From Disc Displacement With Reduction (A Randomized Clinical Trial)
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Temporomandibular Joint Disc Displacement, With Reduction
Lead sponsor: University of Alexandria
Sponsor class: OTHER
First posted: 2022-01-18
Enrollment: 27
Sex: ALL
Minimum age (years): 20
Maximum age (years): 40
Standard ages: ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: Aim of the current study is to compare the efficacy of Low Level Laser, Botulinum toxin type A, and repositioning appliance in management of reduced temporomandibular joint disc.


Eligibility criteria: Inclusion Criteria:

* TMJ with audible and palpable click.
* Patients with anterior disc displacement as detected by MRI.
* Presence of full or nearly full complement of natural teeth.

Exclusion Criteria:

* Patients who have radiographic evidence of degenerative conditions of TMJ.
* Patients who have anterior disc dislocation without reduction.
* Previous history of TMD treatment.
* History of recent trauma.
* The presence of systemic diseases (i.e. rheumatoid arthritis, osteoarthritis).
* Inability or unwillingness to undergo magnetic resonance imaging (MRI) such as implanted electronic devices.
* Pregnant and lactating females.
* Patients with known allergy to botulinum toxin type A.
* Patients suffering from neurological disorders.

Primary outcomes:
measure: Temporomandibular joint dysfunction
timeFrame: 3 months
measure: Pain level
timeFrame: 3 months
measure: Temporomandibular joint clinical evaluation
timeFrame: 3 months
Secondary outcomes:
Other outcomes:
Locations:
city: Alexandria
country: Egypt
facility: Faculty of Dentistry, Alexandria University
Study officials:
affiliation: Faculty of Dentistry, Alexandria University, Egypt
name: Mariam M Bahgat, M.Sc
role: PRINCIPAL_INVESTIGATOR
affiliation: Faculty of Dentistry, Alexandria University, Egypt
name: Nermeen A Rady, PhD
role: STUDY_DIRECTOR
affiliation: Faculty of Dentistry, Alexandria University, Egypt
name: Ahmed M Abdelhamid, PhD
role: STUDY_CHAIR
References:
Clinical trial NCT01667588: Sleep Disorders in Pediatric Dialysis
Official title: Sleep Disorders in Pediatric Dialysis
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Chronic Kidney Disease (CKD)
Keywords: Chronic Kidney Disease (CKD)
Pediatrics
Sleep Disorders
Lead sponsor: The Hospital for Sick Children
Sponsor class: OTHER
First posted: 2012-08-17
Enrollment: 19
Sex: ALL
Minimum age (years): 1
Maximum age (years): 18
Standard ages: CHILD
ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: The two study cohorts will be age and sex matched and constructed as follows:

1. Pre-dialysis: Stage 4 CKD with an estimated GFR of 15-30 ml/min/1.73m2 based on IDMS Schwartz GFR
2. Dialysis: CKD receiving outpatient hemodialysis (HD) or peritoneal dialysis (PD) for a minimum of 1 month. The PSG will be completed after the longest inter-dialytic interval for HD patients. Patients on PD will undergo PSG while on their usual cycler nocturnal dialysis regimen.

Brief summary: Sleep disorders (SD) are common in adults with Chronic Kidney Disease (CKD) on dialysis with a reported prevalence of 60-80%. To date three studies have reported on SDs in children with CKD but these have all been based on questionnaire data alone. The findings were not confirmed with polysomnograms (PSG), the gold standard to diagnose SD, or actigraphy, a validated tool to assess the sleep/ wake cycle over a prolonged period in the home. This is highly relevant given the poor sensitivity and specificity of even validated questionnaires alone. The effect of untreated pediatric SD is pervasive. This study will provide the first objective assessment of SDs using PSGs in children with severe CKD, both on and off dialysis. Therefore, we will recognize and when possible treat SD in this severe CKD cohort potentially contributing to their immediate management (eg improved control of hypertension, improved school performance), while improving their Quality of Life (QOL) and helping ensure they achieve their full potential.


Eligibility criteria: Inclusion Criteria:

* 0 to 18 years
* Caregivers must be able to read English
* Patients with either Stage 4 Chronic Kidney Disease (CKD) with an estimated GFR of 15-30 ml/min/1.73m2 based on IDMS Schwartz GFR OR patients with CKD receiving outpatient hemodialysis (HD) or peritoneal dialysis (PD) for a minimum of 1 month
* Informed consent

Exclusion Criteria:

* Caregivers cannot read English
* Informed consent not given

Primary outcomes:
measure: Prevalence of Sleep Disorders
timeFrame: Baseline
Secondary outcomes:
measure: Quality of Life
timeFrame: Baseline
Other outcomes:
Locations:
city: Toronto
country: Canada
facility: The Hospital for Sick Children
state: Ontario
Study officials:
affiliation: The Hospital for Sick Children
name: Reshma Amin, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT06532188: Efficacy of Hypno-ear-acupuncture on Insomnia in Advanced Cancer Patients
Official title: Efficacy of Hypno-ear-acupuncture on Insomnia in Advanced Cancer Patients: a Randomized Clinical Trial
Study type: INTERVENTIONAL
Overall status: NOT_YET_RECRUITING
Phase: NA
Conditions: Oncology
Insomnia
Symptoms and Signs
Keywords: ear acupuncture
medical hypnosis
Lead sponsor: Medical University of Graz
Sponsor class: OTHER
First posted: 2024-08-01
Enrollment: 20
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: This randomized controlled trial aims to test if a combination of medical hypnosis and ear acupuncture improves sleep quality in patients with advanced cancer during a hospital stay in a palliative care unit.

Patients submitted to our palliative care unit will receive a medical hypnosis and ear acupuncture on the second day of their stay. Sleep quality will be measured using validated patient-reported outcome measures at baseline and after 7 days. Additionally, the use of sleep medication will be documented as a secondary outcome.

The intervention will be compared to a sham medical hypnosis and ear acupuncture to see if the effect of the true intervention has a unique effect.


Eligibility criteria: Inclusion Criteria:

* histologically confirmed cancer
* RCSQ total score \<25mm
* ability to read and understand the questionnaires
* ability to give informed consent

Exclusion Criteria:

* pregnancy
* language barrier (non German)
* inability to give informed consent
* hypacusis
* radiographical verified brain metastases
* diagnosed psychosis

Primary outcomes:
measure: Richards-Campbell Sleep Questionnaire (RCSQ)
timeFrame: Baseline and after seven days
Secondary outcomes:
measure: Edmonton symptom assessment scale (ESAS)
timeFrame: Baseline and after seven days
measure: Patient health questionnaire 9 (PHQ-9)
timeFrame: Baseline and after seven days
measure: Use of additional medication
timeFrame: From baseline to end of study (total seven days)
Other outcomes:
Locations:
city: Graz
country: Austria
facility: Medical University of Graz
state: Styria
Study officials:
References:
citation: Ahlberg R, Skarberg K, Brus O, Kjellin L. Auricular acupuncture for substance use: a randomized controlled trial of effects on anxiety, sleep, drug use and use of addiction treatment services. Subst Abuse Treat Prev Policy. 2016 Jul 25;11(1):24. doi: 10.1186/s13011-016-0068-z.
citation: Lam TH, Chung KF, Lee CT, Yeung WF, Yu BY. Hypnotherapy for insomnia: A randomized controlled trial comparing generic and disease-specific suggestions. Complement Ther Med. 2018 Dec;41:231-239. doi: 10.1016/j.ctim.2018.10.008. Epub 2018 Oct 9.
Clinical trial NCT04337788: Gerontological Telemonitoring of Older Adults Living in Nursing Homes With COVID-19 Disease
Official title: Gerontological Telemonitoring of Older Adults Living in Nursing Homes With Symptoms of Confirmed or Probable COVID-19 Disease
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Coronavirus Infection
Keywords: Covid-19, early gerontologic healthcare
Lead sponsor: University Hospital, Limoges
Sponsor class: OTHER
First posted: 2020-04-08
Enrollment: 200
Sex: ALL
Minimum age (years): 75
Standard ages: OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NON_RANDOMIZED
Intervention model: PARALLEL
Intervention model description: Prospective cohort study (here and elsewhere)
Primary purpose: PREVENTION

Brief summary: Since the last 3 months the world copes with the novel coronavirus disease : Covid-19 emerged in China in the end of 2019. WHO declared the pandemic situation as a Public Health Emergency around the world on January 2020.

Firsts studies emphasized on higher risk to older adults to experience serious health consequences : hospitalizations and mortality, due to multimorbidity and multimedication. Nursing home resident are particulary frailer and vulnerable.


Eligibility criteria: Inclusion Criteria:

* Nursing home resident with Covid disease RT-PCR or Chest CT or rapid test
* Nursing home resident with Covid-19 disease symptoms :
* fever
* cough
* dyspnea
* SPO2\<95% in ambient air (or \<91% in COPD patient)
* Diarrhea
* Fall or balance disorder
* Confusion

Exclusion Criteria:

* Age \< 75 years
* Patient in respiratory distress
* No consent

Primary outcomes:
measure: Impact of Gerontological telemonitoring on healthcare management for older adults living in Nursing Homes with symptoms of confirmed or probable COVID-19 disease (Death within 30 days).
timeFrame: day 30
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
References:
Clinical trial NCT05522088: Effectiveness of Prophylactic Bolus Ephedrine Versus Norepinephrine for Management of Post Spinal Hypotension
Official title: Effectiveness of Prophylactic Bolus Ephedrine Versus Norepinephrine for Management of Post Spinal Hypotension During Elective Caesarean Section in Resource Limited Setting: a Prospective Cohort Study
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Comparing Ephedrine With Norepinephrine for Mangement Postspinal Hypotension
Lead sponsor: Wachemo University
Sponsor class: OTHER
First posted: 2022-08-30
Enrollment: 84
Sex: FEMALE
Minimum age (years): 18
Maximum age (years): 35
Standard ages: ADULT
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: All pregnant women undergoing elective cesarean section fulfills the inclusion criteria were the source population

Brief summary: This study was conducted to compare the effectiveness of ephedrine versus norepinephrine for management of hypotension after spinal anesthesia for mothers undergoing elective cesarean section


Eligibility criteria: Inclusion Criteria:

* ASA class II and ages ranging from 18-35 years were included in the study

Exclusion Criteria:

* pregnant women with preeclampsia/eclampsia, baseline hypertension (SBP\> 140 mm Hg), BMI\> 30 kg/m2, failed spinal, spinal anaesthesia converted to general anaesthesia, contraindication for spinal anaesthesia and mother with cardiovascular, renal or hepatic disease.

Primary outcomes:
measure: to compare mean blood pressure (MAP) between the groups
timeFrame: From March,01 to April, 30/2022
Secondary outcomes:
Other outcomes:
Locations:
city: Hosa'ina
country: Ethiopia
facility: Wachemo University
Study officials:
References:
citation: Desalegn M, Shitemaw T, Tamrat H. Effectiveness of Prophylactic Bolus Ephedrine Versus Norepinephrine for Management of Postspinal Hypotension during Elective Caesarean Section in Resource Limited Setting: A Prospective Cohort Study. Anesthesiol Res Pract. 2022 Oct 3;2022:7170301. doi: 10.1155/2022/7170301. eCollection 2022.
Clinical trial NCT06744088: Clinical Outcomes Of Modified Del Nido Cardioplegia In Adult And Pediatric Cardiac Surgery
Official title: Clinical Outcomes Of Modified Del Nido Cardioplegia In Adult And Pediatric Cardiac Surgery; A Multicentered Cross-Sectional Study
Study type: OBSERVATIONAL
Overall status: ACTIVE_NOT_RECRUITING
Conditions: Cardiac Events
Lead sponsor: Superior University
Sponsor class: OTHER
First posted: 2024-12-20
Enrollment: 200
Sex: ALL
Minimum age (years): 1
Maximum age (years): 60
Standard ages: CHILD
ADULT
Accepts healthy volunteers: no
Observational model: CASE_CONTROL
Time perspective: RETROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Modern cardiac surgery prioritizes myocardial protection, incorporating various strategies including cardioplegia to preserve heart function during surgery. The Del Nido (DN) cardioplegia solution, initially for pediatric use, shows promise in adult surgeries due to its longer protection duration and reduced re-dosing needs.

Brief summary: "Introduction: Modern cardiac surgery prioritizes myocardial protection, incorporating various strategies including cardioplegia to preserve heart function during surgery. The Del Nido (DN) cardioplegia solution, initially for pediatric use, shows promise in adult surgeries due to its longer protection duration and reduced re-dosing needs. However, its efficacy in adults remains under-researched.

Detailed description: This study aims to evaluate the clinical outcomes of modified Del Nido cardioplegia in adult and pediatric cardiac surgeries, comparing intraoperative and postoperative metrics to provide evidence on its efficacy and safety.

To assess the clinical outcomes of modified Del Nido cardioplegia in cardiac surgeries across different age groups, focusing on myocardial protection, hemodynamic stability, surgical outcomes, recovery, and complications.

Eligibility criteria: Inclusion Criteria:

* All Pediatric patients with congenital heart diseases.
* Individuals who are capable of giving their informed permission;
* Stable patients undergoing surgical procedures that involve cardiopulmonary bypass and cardiac arrest;
* isolated CABG surgery, or simultaneous CABG;
* isolated single-valve surgery or multiple value procedures.

Exclusion Criteria:

* Previous cardiac surgery
* Patients with preoperative inotropic pharmacologic support
* Patients receiving preoperative mechanical circulatory support,
* Patients with an implanted pacemaker or implantable cardioverter-defibrillator,
* Patients undergoing cardiac surgical procedures
* Patients who underwent off-pump or beating heart CABGs
* Ventilation for the night was scheduled because of severe pulmonary arterial hypertension.
* mediastinal drain causing a delay in extubation, or the need to reopen for bleeding or tamponade.

Primary outcomes:
measure: the Bypass time
timeFrame: up to 12 Months
measure: postoperative mortality
timeFrame: 12 Months
Secondary outcomes:
Other outcomes:
Locations:
city: Peshawar
country: Pakistan
facility: Peshawar
state: Khyber Pakhtunkhwa
Study officials:
References:
Clinical trial NCT02218788: Injectable Filler for Facial Soft Tissue Augmentation
Official title: An Open-label, Retrospective, Postmarketing Study of Safety and Performance of Hydroxytite, a Calcium Hydroxyapatite Based Filler for Facial Soft Tissue Augmentation.
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Wrinkles
Keywords: Nasolabial folds
Marionette lines
Cheek bones
Jaw lines
Lead sponsor: Panaxia Ltd
Sponsor class: INDUSTRY
First posted: 2014-08-18
Enrollment: 218
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: COHORT
Time perspective: RETROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: All patients treated with Hydroxytite, above the age of 18

Brief summary: The purpose of this study is to assess the safety and performance of Hydroxytite in all subjects who have received sub dermal or deep dermal injections.


Eligibility criteria: Inclusion Criteria:

* Patient is over 18 years of age
* Patient received Hydroxytite injection(s).

Exclusion Criteria:

• Patient declines to participate in the study

Primary outcomes:
measure: To assess the safety of Hydroxytite (Crystalys) in subjects who received subdermal or deep-dermal injections
timeFrame: 6 months
Secondary outcomes:
measure: Performance
timeFrame: 6 months
measure: Performance
timeFrame: 6 months
Other outcomes:
Locations:
Study officials:
References:
Clinical trial NCT04985188: Quantitative Ultrasound for Diagnosing Hepatic Steatosis in Nonalcoholic Fatty Liver Multicenter Study
Official title: Quantitative Ultrasound Imaging Parameters for Hepatic Steatosis in Patients With Non-alcoholic Fatty Liver Disease: Multicenter Prospective Study
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Diagnoses Disease
Lead sponsor: Seoul National University Hospital
Sponsor class: OTHER
Collaborators: name: First Affiliated Hospital, Sun Yat-Sen University
name: Ruijin Hospital
name: Shenzhen Second People's Hospital
name: Samsung Medison
First posted: 2021-08-02
Enrollment: 112
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Clinically suspected or proven nonalcoholic fatty liver disease (NAFLD)

Brief summary: To evaluate the diagnostic performance of quantitative ultrasound parameters for assessing hepatic steatosis in non-alcoholic fatty liver disease using histologic results as reference standard


Eligibility criteria: Inclusion Criteria:

* Clinically suspected or proven nonalcoholic fatty liver disease (NAFLD)
* Patients who are scheduled hepatic parenchymal biopsy for suspected liver disease or hepatectomy for living donor liver donation
* aged ≥ 18 years who are willing and able to complete all procedures

Exclusion Criteria:

* excessive alcohol consumption within 2 years (40g/day for men, 20g/day for women)
* clinical, laboratory, or histologic evidence of a liver disease other than NAFLD, including viral hepatitis, autoimmune hepatitis, or genetic or acquired disorders
* use of steatogenic or hepatotoxic medication
* evidence of decompensated liver disease
* history of liver surgery
* any other condition believed by investigator to affect a patients' compliance, or completion of the study

Primary outcomes:
measure: Diagnostic performance of quantitative ultrasound parameters for diagnosing hepatic steatosis (S1)
timeFrame: 1 month
Secondary outcomes:
measure: Diagnostic performance of quantitative ultrasound parameters for diagnosing hepatic steatosis (S2 and S3)
timeFrame: 1 month
measure: Diagnostic performance of quantitative ultrasound parameters for diagnosing nonalcoholic steatohepatitis (NASH)
timeFrame: 1 month
Other outcomes:
Locations:
Study officials:
affiliation: Seoul National University Hospital
name: Jeong Min Lee, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT05509088: Impact of the Early Use of High Flow Nasal Cannula in Patients With Post-traumatic Lung Contusion, a Randomized Clinical Trial
Official title: Impact of the Early Use of High Flow Nasal Cannula in Patients With Post-traumatic Lung Contusion, a Randomized Clinical Trial
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Traumatic Lung Injury
Lead sponsor: Ain Shams University
Sponsor class: OTHER
First posted: 2022-08-19
Enrollment: 120
Sex: ALL
Minimum age (years): 18
Maximum age (years): 80
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: PREVENTION

Brief summary: We hypothesize that early and continuous administration of oxygen via high flow nasal cannula in patients with lung contusion and non-severe acute lung injury might reduce the incidence of intubation and hold the deterioration of pulmonary functions.


Eligibility criteria: Inclusion Criteria:

Willing and able to provide written informed consent prior to performing study procedures, currently hospitalized and requiring medical care for blunt chest trauma, within 24h of trauma

Exclusion Criteria:

* face trauma or surgery, airway obstruction, known to have chronic chest condition

Primary outcomes:
measure: need for intubation and mechanical ventilation within 28 days of randomization.
timeFrame: 3 months
Secondary outcomes:
Other outcomes:
Locations:
city: Cairo
country: Egypt
facility: Ain Shams University hospitals
Study officials:
References:
Clinical trial NCT07020078: Oral Health Condition Among a Group of Ionizing Radiation Field Workers
Official title: Salivary Redox Biomarkers in Relation to Oral Health Condition Among a Group of Ionizing Radiation Field Workers
Study type: OBSERVATIONAL
Overall status: NOT_YET_RECRUITING
Conditions: Salivary Redox Biomarkers and Oral Health
Lead sponsor: Al-Mustansiriyah University
Sponsor class: OTHER
First posted: 2025-06-13
Enrollment: 90
Sex: MALE
Minimum age (years): 30
Maximum age (years): 40
Standard ages: ADULT
Accepts healthy volunteers: yes
Observational model: CASE_CROSSOVER
Time perspective: CROSS_SECTIONAL
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Male workers in radiation field from 30_40 years old who exposed to radiation for 5_10 years and compare them with male workers in laboratory at age 30_40 years

Brief summary: The goal of this study is to test the effect of ionizing radiation on salivary Redox status among a group of ionizing radiation workers by measuring salivary biomarkers(malondialdehyde,8_hydroxy_deoxyguanosine and catalase) and measuring oral health condition by plaque index.

90 male subjects will be enrolled in this study between 30_40 years old worked in Baghdad teaching hospital ,30 subjects exposed from computed tomography department ,30 subjects exposed from x_ray department and 30 subjects unexposed from laboratory department in the same hospitals.

The method of the study is taking unstimulated saliva sample from the subjects and oral health measure.


Eligibility criteria: Inclusion Criteria:

* male, 30_40 years ,no history of systemic disease, no medical treatment taken at least 3 months before sampling and the subjects are exposed to radiation 5_ 10 years

Exclusion Criteria:

* subjects with medical history , subjects are taken medications during last 3 months , the subjects are exposed to radiation less than 5 years or more than 10 years

Primary outcomes:
measure: oral health status
timeFrame: Baseline: the subjects must be fasting. up to two hours saliva collection
Secondary outcomes:
measure: Salivary Malondialdehyde biomarker
timeFrame: Baseline:saliva collection for malondialdehyde . up to two hours fasting for all subjects.
measure: Salivary 8_ hydroxy_deoxyguanosine biomarker
timeFrame: Baseline:saliva collection for 8_hydroxy_deoxyguanosine .up to two hours fasting for all subjects.
measure: Salivary catalase biomarker
timeFrame: Baseline:saliva collection for catalase . up to two hours fasting for all subjects.
Other outcomes:
Locations:
Study officials:
References: