louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT01335828: Elastography Interest in the Management of Thyroid Nodules
Official title: "ShearWave" Elastography Interest in the Management of Thyroid Nodules
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE2
PHASE3
Conditions: Thyroid Nodules
Keywords: Echography
Elastography
Thyroid nodules
Needles punction
Thyroid surgery
Patients with thyroids nodules
Lead sponsor: University Hospital, Grenoble
Sponsor class: OTHER
First posted: 2011-04-14
Enrollment: 125
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NON_RANDOMIZED
Intervention model: PARALLEL
Primary purpose: DIAGNOSTIC

Brief summary: Define an ultrasound/elastography benignity criteria in strategy management of a patient population carries one or more thyroid nodules.


Eligibility criteria: Inclusion Criteria:

* Patient aged over 18 years old
* Patient affiliated to social security or similarly regime
* Patients referred for fine needle aspiration or surgery with one or more thyroid nodules

Exclusion Criteria:

* Patients with too much thyroid nodules or topography too imprecise to allow unambiguous correlation between echo/elastography data and histology/cytology data
* Patients withan echography/elastography indications cons
* Pregnant women and lactating mothers
* Adult unable to express their consent
* Ward of court or under guardianship
* Person under legal protection
* Person deprived of freedom by judicial or administrative decision
* Person hospitalized without their consent

Primary outcomes:
measure: Defined echo/elastography benignity criteria
timeFrame: two and half years
Secondary outcomes:
measure: Evaluate the diagnostic performance of elastography ShearWave for characterization of thyroid nodules in a population of patients referred for needle biopsy or surgery nodule thyroid
timeFrame: two and half years
measure: Assessing the use of elastography in clinical practice
timeFrame: two and half years
Other outcomes:
Locations:
city: Grenoble
country: France
facility: Clinical Investigation Center - Technological Innovation - Inserm 803 - University Hospital France
Study officials:
References:
Clinical trial NCT06937528: Use of Extracellular Vesicles (EV) for Knee Osteoarthrosis
Official title: Knee Osteoarthrosis (KOA) in Jordanian Patients: a Phase I Dose-finding Study Using Extracellular Vesicles (EV) for Advanced Stage III and IV KOA
Study type: INTERVENTIONAL
Overall status: RECRUITING
Phase: PHASE1
Conditions: Knee Osteoarthrosis
Keywords: osteoarthrosis
Knee
Extracellular vesicles
Lead sponsor: University of Jordan
Sponsor class: OTHER
Collaborators: name: Abdalla Awidi Abbadi, MD
name: The University of Jordan
First posted: 2025-04-22
Enrollment: 50
Sex: ALL
Minimum age (years): 42
Maximum age (years): 75
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: TREATMENT

Brief summary: Extracellular vesicles (EV) will be injected in patients diagnosed with Knee osteoarthrosis

Detailed description: 50 patients from both genders diagnosed with Knee osteoarthrosis, will be enrolled according to strict inclusion and exclusion criteria. These patients will be injected with Extracellular vesicles (EV). Then, they are followed by clinical assessment, laboratory investigations as well as magnetic resonance imaging (MRI) of the injected knee.

Eligibility criteria: Inclusion Criteria:

* Severe KOA stage III or IV by Laurance \& Kellgren staging as judged by Posterioranterior (PA) Xray of the knee joint.
* Willing to participate by signing the informed consent

Exclusion Criteria:

* Sublaxation beyond 20 degrees of the bones of the knee joint
* Oral anticoagulants or heparin therapy
* Heart failure or arrhythmia
* Body Mass Index \> 35
* Uncontrolled Diabetes Mellitus.
* Evidence of Infectious Diseases.
* Active infection
* Malignancy
* Pregnancy
* Anemia less than 11g/dl or thrombocytopenia less than 100,000 or leucopenia less than 3000.
* Unreliable patients
* Non-resident in Jordan

Primary outcomes:
measure: Safety
timeFrame: follow-up duration is 12 months
Secondary outcomes:
measure: Efficacy
timeFrame: follow-up duration is 12 months
Other outcomes:
Locations:
city: Amman
country: Jordan
facility: Cell Therapy Center
Study officials:
References:
Clinical trial NCT03619928: Comparison of Dry Needle and Massotherapy on Tolerance Effort and Soreness
Official title: Comparison of Dry Needle and Massotherapy on Tolerance to the Effort and Soreness of Individuals With Late Muscular Pain Induced by Exercise
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Delayed Onset Muscle Soreness
Keywords: Dry needling
Massotherapy
Delayed onset muscle soreness
Lead sponsor: Universidade Federal de Pernambuco
Sponsor class: OTHER
First posted: 2018-08-08
Enrollment: 20
Sex: ALL
Minimum age (years): 18
Maximum age (years): 45
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: Introduction: Delayed onset muscle soreness (DOMS) is a common myogenic condition considered to be a muscle tension injury frequently observed in recreational or experienced athletes, induced in the majority of cases by eccentric and inactive exercises, the most common of which are: tension, pain and impairment muscular and have a course of typical duration of 24 hours and peak between 48 and 72 hours. Among the treatments proposed with the aim of reducing the symptoms of DOMS is massage therapy. However, dry needling is a relatively new technique that has been used in myotendinous lesions and its effects on late muscle pain have not yet been studied. Objective: To compare the impact of dry needling and massage therapy on exercise tolerance, and analgesia of sedentary individuals with late muscle pain induced by eccentric exercise. The present study is characterized as a randomized and blinded comparative study in which male sedentary individuals will be invited in which the late muscle pain will be induced through eccentric contractions and will receive different treatments: dry needling or massage therapy. The upper limb functionality, pain perception, superficial hyperemia and brachial biceps thickness will be compared through the exams: visual analogue pain scale (VAS), digital algometry, thermography, ultrasonography and isometric test.


Eligibility criteria: Inclusion Criteria:

not practicing physical activity BMI greater than 18 and less than 30 members of the UFPE community

Exclusion Criteria:

making use of analgesic or anti-inflammatory medications acupuncture or dry needling or massage therapy in the last 6 months report of muscle pain orthopedic neurological problems hypertension and diabetes cardiovascular or respiratory diseases

Primary outcomes:
measure: Pressure pain threshold
timeFrame: 48 hours
measure: Delayed onset muscle soreness
timeFrame: 48 hours
Secondary outcomes:
measure: Muscle thickness
timeFrame: 48 hours
measure: Temperature
timeFrame: 48 hours
measure: Time limit
timeFrame: 48 hours
Other outcomes:
Locations:
city: Recife
country: Brazil
facility: Romero Souza Leão de Albergaria Crasto
state: Pernambuco
Study officials:
affiliation: Master student, program in physical therapy
name: Romero SL Crasto, Esp.
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT05157828: Iron Deficiency Anaemia in Pregnant Patients Presenting for Antenatal Care
Official title: A Cross-sectional Prospective Study of the Prevalence of Iron Deficiency Anaemia in Pregnant Patients Presenting for Antenatal Care at a Secondary Level Institution, Mowbray Maternity Hospital
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Iron Deficiency Anemia of Pregnancy
Lead sponsor: University of Cape Town
Sponsor class: OTHER
First posted: 2021-12-15
Enrollment: 132
Sex: FEMALE
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: OTHER
Time perspective: CROSS_SECTIONAL
Sampling method: NON_PROBABILITY_SAMPLE
Study population: This study will include all consenting patients presenting to the Antenatal Clinic at Mowbray Maternity Hospital, for antenatal care, during the one-week period of recruitment.

Brief summary: This is a cross-sectional, prospective study of iron deficiency anaemia among pregnant patients presenting for antenatal care at a secondary level institution in the Western Cape, Mowbray Maternity Hospital, over a one-week period.


Eligibility criteria: Inclusion Criteria:

* All women presenting to the antenatal care services at Mowbray Maternity Hospital over the period of study recruitment.
* ≥ 18 years of age.
* Screen as anaemic (World Health Organisation \<11g/dl) on bedside finger-prick haemoglobin.
* Who consent to participate.

Exclusion Criteria:

Patients who refuse to participate, and those under the age of 18 years will be excluded from the study.

Primary outcomes:
measure: Prevalence of anaemia among all women presenting for antenatal care at a secondary level institution in the Western Cape, Mowbray Maternity Hospital, during a one-week period.
timeFrame: One week
Secondary outcomes:
Other outcomes:
Locations:
city: Cape Town
country: South Africa
facility: Mowbray maternity hospital
state: Western Cape
Study officials:
affiliation: University of Cape Town
name: Christella Alphonsus, MBChB
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT06009328: Fundamental Movement Skills, Body Mass Index and Quality of Life in Children
Official title: Correlation Between Fundamental Movement Skills, Body Mass Index, and Quality of Life in School Aged Children
Study type: OBSERVATIONAL
Overall status: RECRUITING
Conditions: Overweight Children
Lead sponsor: Cairo University
Sponsor class: OTHER
First posted: 2023-08-24
Enrollment: 216
Sex: ALL
Minimum age (years): 5
Maximum age (years): 7
Standard ages: CHILD
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: normal school aged children from 5-8 years

Brief summary: Early childhood obesity is a serious worldwide problem, and fundamental movement skills (FMS) are very important factors in human movement. Thus, several advanced studies have examined the associations between FMS, body mass index (BMI) and quality of life.

The purpose of this study was to investigate the relation between FMS, BMI and quality of life in Egyptian school aged children.

Detailed description: A total of 216 primary school aged children, aged 5-7 y from both sex participated in this study. FMS were measured using the Test of Gross Motor Development-II (TGMD-II), and BMI was calculated as the weight (kg) divided by the square of the height (m) \[weight/ height2\] ,and quality of life was measured by PedsQol scale

Eligibility criteria: Inclusion Criteria:

- normal school aged children , aged 5-7 years with different weight categories

Exclusion Criteria:

* children with visual or auditory problems or those who experienced surgery in their lower limbs 1 year before study

Primary outcomes:
measure: test of gross motor development
timeFrame: 3 months
measure: body mass index
timeFrame: 3 months
measure: PedsQol scale
timeFrame: 3 months
Secondary outcomes:
Other outcomes:
Locations:
city: Cairo
country: Egypt
facility: Faculty Of Physical Therapy
Study officials:
References:
Clinical trial NCT02197728: Comparing Two Devices of Uterine Manipulation and Vaginal Fornix Delineation at Total Laparoscopic Hysterectomy
Official title: Comparing Two Devices of Uterine Manipulation and Vaginal Fornix Delineation at Total Laparoscopic Hysterectomy
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Laparoscopic Hysterectomy for Benign Conditions
Keywords: hysterectomy, uterine manipulator, thermal damage, laparoscopy, colpotomy
Lead sponsor: Unity Health Toronto
Sponsor class: OTHER
First posted: 2014-07-23
Enrollment: 91
Sex: FEMALE
Minimum age (years): 18
Maximum age (years): 80
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: We hypothesize, that the use of the Hohl manipulator® at total laparoscopic hysterectomy reduces operative time (from skin incision to detachment of the uterus) and lateral termal damage of the vaginal wall during colpotomy due to the following reasons: (1) Uterine manipulation is better with the Hohl manipulator®, thereby facilitating dissection during all aspects of the surgery, (2) more tension can be applied on the vagina during colpotomy, thereby hastening electrosurgical transection, reducing activation time and reduce lateral thermal damage and (3) tension on the vagina can be applied until the colpotomy is finished, due to the tight connection between the Hohl manipulator® and the cervix of the uterus, which also affects speed of transection, electrosurgical device activation time and lateral thermal damage.


Eligibility criteria: Inclusion Criteria:

* All women aged over 18 years, scheduled for a laparoscopic hysterectomy for a benign disorder will be asked to participate and included after written informed consent.

Exclusion Criteria:

* pregnancy
* malignancy
* if uterine size exceeds 20 weeks of gestation
* or if the uterus could be removed by a vaginal approach

Primary outcomes:
measure: Detachment of the uterus
timeFrame: 45 minutes to 3 hours
measure: Thermal Damage
timeFrame: 2 weeks post surgery
measure: Colpotomy
timeFrame: 3 minutes to 20 minutes
Secondary outcomes:
measure: Blood Loss
timeFrame: 45 minutes to 3 hours
measure: Pain
timeFrame: 24h post surgery
measure: Manipulator Installment
timeFrame: intraoperative
Other outcomes:
Locations:
city: Toronto
country: Canada
facility: St. Michael´s Hospital
state: Ontario
Study officials:
affiliation: Unity Health Toronto
name: Guylaine Lefebvre, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT06407128: Valvular Microbiota and Valvulopathy
Official title: Valvular Microbiota and Valvulopathy
Study type: INTERVENTIONAL
Overall status: RECRUITING
Phase: NA
Conditions: Valvulopathy
Keywords: Microbiota
Lead sponsor: University Hospital, Toulouse
Sponsor class: OTHER
First posted: 2024-05-09
Enrollment: 100
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: SCREENING

Brief summary: Few teams in the world can reliably analyze tissue microbiota. In this regard, the present group has unique expertise in the analysis of blood and tissue microbiota, the first to describe in 2011.

Having a blood biomarker of this valve microbiota could help guide the therapeutic strategy before and after the intervention. This study will be the first to test the hypothesis that the analysis of the blood microbiota makes it possible to detect the carriage of a tissue microbiota in patients undergoing aortic valve replacement (AVR) for degenerative aortic valve disease and should also lay the foundations for a prospective study. intended to evaluate the impact of the blood and valve microbiota on the post-operative prognosis of these patients and the complications at one year. This would be a first proof of concept of the role of the tissue microbiota in valvular degeneration linked to aging.


Eligibility criteria: Inclusion Criteria:

* Indication for surgical AVR:

  * Tight RA:

    * symptomatic (dyspnea, syncope/lipothymia, angina);
    * and/or echocardiographic criterion:
* valve surface \< 1cm2 (and/or 0.6cm2/m2);
* average transvalvular gradient \> 40mmHg;
* aortic jet velocity (Vmax) \> 4.0m/s;

  * or low transvalvular gradient (mean gradient \< 40mmHg) + left ventricular ejection fraction (LVEF) \< 50% but contractile reserve;
  * and/or high calcium score on CT angiography;

    * Asymptomatic tight RA and:
  * LVEF \< 50% without other cause;
  * and/or symptoms during exercise;
  * and/or low surgical risk + severity criteria: Vmax \> 5.5m/s (or progression \> 0.3m/s/year), NT-proBNP level \> 3Xnormal, severe pulmonary arterial hypertension (pulmonary systolic pressure \> 60mmHg);

    * Moderate AR + concomitant surgical indication for another heart disease;
    * Severe AI: regurgitant orifice \> 30mm2, regurgitated volume \> 60ml/beat,
  * symptomatic (dyspnea, syncope/lipothymia, angina);
  * and/or left ventricular dysfunction: LVEF \< 50%, end-diastolic diameter \> 70mm, end-systolic diameter \> 50mm (or \> 25mm/m2);
  * and/or concomitant surgical indication for another heart disease.

Primary outcomes:
measure: Detection of blood and tissue microbiota
timeFrame: 12 months
Secondary outcomes:
Other outcomes:
Locations:
city: Toulouse
country: France
facility: University Hospital
Study officials:
affiliation: University Hospital, Toulouse
name: Jean PORTERIE, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT03532828: Interaction Between Body Posture and Nocturnal Sleeping Disorders in Dysgnathic Patients
Official title: Nocturnal Respiratory Disorders Identification and Their Influence on the Body Posture and Breathing Synchronisation in Patients With Dentofacial Dysgnathia
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Dentofacial Deformities
Sleep Disorder
Posture
Lead sponsor: Laboratoire de Biomécanique Georges Charpak
Sponsor class: OTHER
First posted: 2018-05-22
Enrollment: 100
Sex: ALL
Minimum age (years): 16
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NON_RANDOMIZED
Intervention model: SINGLE_GROUP
Primary purpose: BASIC_SCIENCE

Brief summary: The role of head posture has been demonstrated in patient with dentofacial deformities. However, the relationship between body posture and jaw disorders is unclear. Moreover, patients with obstructive sleep apnea have the same anatomical abnormalities than patients with dentofacial deformities. The aim of this study is to evaluate, firstly, nocturnal sleeping disorders among patients with jaw disorders. Secondly, the investigators aim to evaluate the interaction between body posture, breathing and dentofacial deformities.

A polygraphy will be performed on patient with dentofacial deformities before and after correcting jaw surgery. A postural evaluation will be done using EOS imaging system and a force plate


Eligibility criteria: Inclusion Criteria:

* patient in orthodontic preparation for a surgical treatment,
* age \> 16 years

Exclusion Criteria:

* postural disorder (scoliosis, history of spine surgery),
* pregnancy or breastfeeding,
* patients under guardianship

Primary outcomes:
measure: Change in 2D displacement range of the pressure center
timeFrame: Baseline, 1 year
Secondary outcomes:
measure: Change in EOS criteria description
timeFrame: Baseline, 1 year
measure: Change Stabilometric criteria description
timeFrame: Baseline, 1 year
measure: Change in Cephalometric analysis
timeFrame: Baseline, 1 year
measure: Change Polygraphy criteria description
timeFrame: Baseline, 1 year
measure: Change in Dentofacial deformities description
timeFrame: Baseline, 1 year
Other outcomes:
Locations:
city: Paris
country: France
facility: Laboratoire de biomécanique Georges CHarpak
Study officials:
References:
Clinical trial NCT01328028: Human Papillomavirus (HPV) Type Distribution in Adult Women Diagnosed With Invasive Cervical Cancer in New Zealand
Official title: Hospital-based Epidemiological Study on the Distribution of Human Papillomavirus (HPV) Types in Adult Women Diagnosed With Invasive Cervical Cancer (ICC) in New Zealand
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Cervical Cancer
Keywords: Invasive cervical cancer
Human papillomavirus
Lead sponsor: GlaxoSmithKline
Sponsor class: INDUSTRY
First posted: 2011-04-04
Enrollment: 244
Sex: FEMALE
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: CASE_ONLY
Time perspective: RETROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Women aged \>= 18 years at the time that the cervical specimen was taken, and diagnosed with invasive cervical cancer stage IB or greater

Brief summary: The aim of this study is to assess the distribution of the most frequent types of human papillomavirus in women diagnosed with invasive cervical cancer in New Zealand.


Eligibility criteria: Inclusion Criteria:

* A female aged 18 years and above at the time of cervical specimen collection, and currently residing in New Zealand.
* Histological diagnoses of invasive cervical cancer stage IB or greater, within at least the last 3 years.
* Written informed consent obtained from the subject/ next of kin/ Legally acceptable representative.
* Availability of cervical specimen on which the diagnosis was made prior to any chemotherapy or radiotherapy.
* The cervical specimen should be of appropriate size and with regular tissue specimens.
* The cervical specimen should be adequately preserved.
* All links to the subject's identity should be removed from the paraffin block.

Exclusion Criteria:

Not Applicable.

Primary outcomes:
measure: Occurrence of HPV-16 and HPV-18 in women with invasive cervical cancer
timeFrame: At least the last 3 years from the time of study start
Secondary outcomes:
measure: Occurrence of other high-risk HPV types in women with invasive cervical cancer
timeFrame: At least the last 3 years from the time of study start
measure: Occurrence of HPV-16/ HPV-18 co-infection with other high-risk HPV types in women with invasive cervical cancer
timeFrame: At least the last 3 years from the time of study start
measure: Occurrence of low-risk HPV types in women diagnosed with invasive cervical cancer
timeFrame: At least the last 3 years from the time of study start
Other outcomes:
Locations:
Study officials:
affiliation: GlaxoSmithKline
name: GSK Clinical Trials
role: STUDY_DIRECTOR
References:
citation: Sykes P, Gopala K, Tan AL, Kenwright D, Petrich S, Molijn A, Chen J. Type distribution of human papillomavirus among adult women diagnosed with invasive cervical cancer (stage 1b or higher) in New Zealand. BMC Infect Dis. 2014 Jul 8;14:374. doi: 10.1186/1471-2334-14-374.