Clinical trial NCT04127240: The Effect of the DASH Diet Containing Meat on Muscle and Metabolic Health in Older Adults
Official title: The Effect of Meat Intake as a Part of the DASH Diet on Indices of Muscular Fitness, Body Composition and Metabolic Health in Adults 65 and Older: A Controlled-Feeding Systems-Biology Study
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Obesity
Sarcopenia
Aging
Lead sponsor: South Dakota State University
Sponsor class: OTHER
First posted: 2019-10-15
Enrollment: 46
Sex: ALL
Minimum age (years): 65
Standard ages: OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: OTHER

Brief summary: Age-related changes in body composition, muscular fitness, and metabolic health resulting in the onset of obesity, sarcopenia, and chronic diseases are profound public health issues that are in need of immediate attention. Effective and feasible methods, such as dietary therapies, are needed to improve health in older adults that in turn lead to independence, enhanced quality of life and reduced hospitalizations. Diet quality and dietary protein intake are vital for maintaining body composition, muscle mass and improved physical performance. Malnutrition in dietary protein intake is a major cause of reduced muscle mass, strength, and function in older adults. The Dietary Approaches to Stop Hypertension (DASH) dietary pattern is a high-quality therapeutic diet known to improve health status in various diverse and at-risk populations resulting in improved heart health, maintained cognitive function and reductions in metabolic diseases such as diabetes, metabolic syndrome, and nonalcoholic fatty liver disease. The primary protein recommendations of the DASH diet are poultry and fish and it is recommended to decrease or exclude red meats from the diet. However, studies have demonstrated that lean red meat incorporated into a DASH-like diet doesn't exacerbate cardiovascular health indices in adults, indicating that lean red meat can be included in the DASH diet without negative effects on heart health. Although studies have reported on the DASH diet in older adults, no studies have investigated the effect of the DASH diet containing lean red meat on measures of body composition, muscle mass or metabolic health under controlled-feeding conditions. The purpose of this study was to determine the effect of the DASH diet containing daily intakes of lean red meat on indicators of body composition, muscular fitness and biomarkers of metabolic health in adults 65 and older using controlled-feeding and systems biology approaches.


Eligibility criteria: Inclusion Criteria:

* 65 and older
* Upward mobile ability

Exclusion Criteria:

* Under the age of 65
* Immobility

Primary outcomes:
measure: Body weight
timeFrame: Change in body weight from baseline to 3 months
measure: Hand grip strength
timeFrame: Change in strength from baseline to 3 months
measure: Glucose
timeFrame: Change in glucose concentrations from baseline to 3 months
Secondary outcomes:
Other outcomes:
Locations:
city: Brookings
country: United States
facility: South Dakota State University
state: South Dakota
Study officials:
affiliation: South Dakota State University
name: Cydne A Perry, PhD
role: PRINCIPAL_INVESTIGATOR
References:
citation: Perry CA, Van Guilder GP, Butterick TA. Decreased myostatin in response to a controlled DASH diet is associated with improved body composition and cardiometabolic biomarkers in older adults: results from a controlled-feeding diet intervention study. BMC Nutr. 2022 Mar 15;8(1):24. doi: 10.1186/s40795-022-00516-9.