Clinical trial NCT02735707: Randomized, Embedded, Multifactorial Adaptive Platform Trial for Community- Acquired Pneumonia
Official title: Randomized, Embedded, Multifactorial Adaptive Platform Trial for Community- Acquired Pneumonia
Study type: INTERVENTIONAL
Overall status: RECRUITING
Phase: PHASE3
Conditions: Community-acquired Pneumonia, Influenza, COVID-19
Keywords: Pneumonia
Lung Diseases
Respiratory Tract Diseases
Respiratory Tract Infections
Anti-Bacterial Agents
Moxifloxacin
Levofloxacin
Antibiotics
Hydrocortisone
Anti-Infective Agents
Ceftriaxone
Piperacillin-tazobactam
Ceftaroline
Amoxicillin-clavulanate
Oseltamivir
COVID-19
Influenza
Intensive care
Critical care
SARS-CoV-2
Vitamin C
Therapeutic Anticoagulation
Statin
Invasive Mechanical Ventilation
Convalescent plasma
Eritoran
Apremilast
DMX-200
Ivermectin
Baloxavir
Tocilizumab
Baricitinib
Imatinib
Lead sponsor: UMC Utrecht
Sponsor class: OTHER
Collaborators: name: Australian and New Zealand Intensive Care Research Centre
name: Medical Research Institute of New Zealand
name: Unity Health
name: Berry Consultants
name: Global Coalition for Adaptive Research
name: University of Pittsburgh Medical Center
name: Intensive Care National Audit & Research Centre
name: St. Marianna University School of Medicine
name: Nat Intensive Care Surveillance - MORU
name: National University Hospital, Singapore
First posted: 2016-04-13
Enrollment: 20000
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: FACTORIAL
Intervention model description: Adaptive Bayesian Platform Trial evaluating multiple interventions in multiple domains
Primary purpose: TREATMENT

Brief summary: REMAP-CAP is a randomised, embedded, multifactorial, adaptive platform trial for community-acquired pneumonia.

The purpose of this study is to evaluate the effect of a range of interventions to improve outcome of patients admitted to intensive care with community-acquired pneumonia.

In addition, REMAP-CAP provides and adaptive research platform for evaluation of multiple treatment modalities in the event of a respiratory pandemic such as COVID-19.

REMAP-COVID is a sub-platform of REMAP-CAP that evaluates treatments specific to COVID-19 in the United States of America.

Detailed description: Community-acquired pneumonia (CAP) that is of sufficient severity to require admission to an intensive care unit (ICU) is associated with substantial mortality.

Patients with pneumonia who are being treated in an ICU will receive therapy that consists of many different treatments, as many as 20 or 30. These treatments act together to treat both the infection and its effects on the body. When treating a patient, doctors choose from many different treatments, most of which are known or believed to be safe and effective. However, doctors don't always know which treatment option is the better one, as individuals or groups of individuals may respond differently. This study aims to help doctors understand which treatments work best.

This clinical study has been designed in a way that allows the information from patients already in the study to help new patients joining the study. Most studies aren't able to do that. REMAP-CAP has been designed to:

* Evaluate multiple treatment strategies, at the same time, in the same patient.
* Reach platform conclusions when sufficient data is accrued, rather than when a pre-specified sample size is reached
* Utilise data that is already accrued to increase the likelihood that patients within the trial are randomised to treatments that are more likely to be beneficial
* New questions can be substituted into the trial as initial questions are answered, meaning that the trial can be perpetual or open-ended
* Interactions between interventions in different domains can be evaluated

It is reasonable to presume that any pandemic respiratory infection of major significance to public health will manifest as life-threatening respiratory infection including Severe Acute Respiratory illness and severe Community Acquired Pneumonia (CAP) with concomitant admission to hospital, and for some patients, admission to an Intensive Care Unit (ICU). Previous pandemics and more localized outbreaks of respiratory emerging infections have resulted in severe CAP and ICU admission.

Previous pandemics and outbreaks of emerging infectious diseases have outlined the urgent need for evidence, preferably from Randomized Controlled Trials (RCTs), to guide best treatment. However, there are substantial challenges associated with being able to organize such trials when the time of onset of a pandemic and its exact nature are unpredictable. As an adaptive platform trial that enrolls patients during the interpandemic period, REMAP-CAP is ideally positioned to adapt, in the event of a respiratory pandemic, to evaluate existing treatments as well as novel approaches.

Eligibility criteria: REMAP-CAP PLATFORM INCLUSION CRITERIA:

1. Adult patient admitted to an ICU for severe CAP within 48 hours of hospital admission with:

   1. symptoms or signs or both that are consistent with lower respiratory tract infection AND
   2. Radiological evidence of new onset consolidation (in patients with pre-existing radiological changes, evidence of new infiltrate)
2. Up to 48 hours after ICU admission, receiving organ support with one or more of:

   1. Non-invasive or Invasive ventilatory support;
   2. Receiving infusion of vasopressor or inotropes or both

PLATFORM EXCLUSION CRITERIA:

1. Healthcare-associated pneumonia:

   1. Prior to this illness, is known to have been an inpatient in any healthcare facility within the last 30 days
   2. Resident of a nursing home or long term care facility
2. Death is deemed to be imminent and inevitable during the next 24 hours AND one or more of the patient, substitute decision maker or attending physician are not committed to full active treatment
3. Previous participation in this REMAP within the last 90 days

REMAP-COVID PLATFORM INCLUSION CRITERIA

1. Adult patients (≥ 18 years) admitted to hospital with acute illness due to suspected or proven pandemic infection.

REMAP-COVID PLATFORM EXCLUSION CRITERIA

1. Death is deemed to be imminent and inevitable during the next 24 hours AND one or more of the patient, substitute decision maker or attending physician are not committed to full active treatment
2. Patient is expected to be discharged from hospital today or tomorrow
3. More than 14 days have elapsed while admitted to hospital with symptoms of an acute illness due to suspected or proven pandemic infection.
4. Previous participation in this REMAP within the last 90 days

DOMAIN-SPECIFIC ELIGIBLE CRITERIA:

Each domain may have additional eligibility criteria. Refer to the study website for more information (www.remapcap.org).

Primary outcomes:
measure: All-cause mortality
timeFrame: Day 90
measure: Days alive and not receiving organ support in ICU
timeFrame: Day 21
Secondary outcomes:
measure: ICU Mortality
timeFrame: Day 90
measure: ICU length of stay
timeFrame: Day 90
measure: Hospital length of stay
timeFrame: Day 90
measure: Ventilator free days
timeFrame: Day 28
measure: Organ failure free days
timeFrame: Day 28
measure: All-cause mortality
timeFrame: 6 months
measure: Health-related Quality of life assessment
timeFrame: 6 months
measure: Proportion of intubated patients who receive a tracheostomy
timeFrame: Day 28
measure: Destination at time of hospital discharge
timeFrame: Free text Day 90
measure: Readmission to the index ICU during the index hospitalization
timeFrame: Day 90
measure: World Health Organisation 8-point ordinal scale outcome
timeFrame: Hospital discharge
Other outcomes:
measure: Occurrence of multi-resistant organism colonisation/infection
timeFrame: Day 90, censored at hospital discharge
measure: Occurrence clostridium difficile
timeFrame: Day 90, censored at hospital discharge
measure: Occurrence of serious ventricular arrhythmia (including ventricular fibrillation) or sudden unexpected death
timeFrame: Day 90, censored at hospital discharge
measure: Change from baseline influenza virus levels in upper and lower respiratory tract specimens
timeFrame: Day 3, up to Day 7
measure: Confirmed deep vein thrombosis
timeFrame: Between randomisation and hospital discharge
measure: Confirmed pulmonary embolism
timeFrame: Between randomisation and hospital discharge
measure: Confirmed ischaemic cerebrovascular event
timeFrame: Between randomisation and hospital discharge
measure: Total red blood cell units transfused
timeFrame: Between randomisation and end of study day 15
measure: Confirmed acute myocardial infarction
timeFrame: Between randomisation and hospital discharge
measure: Peak troponin
timeFrame: Between randomisation and end of study day 15
measure: Major bleeding event
timeFrame: Between randomisation and end of study day 15
measure: Other confirmed thrombotic event, including mesenteric ischaemia and limb ischaemia
timeFrame: Between randomisation and hospital discharge
measure: Acute kidney injury (KDIGO stage >= 2 acute kidney injury)
timeFrame: Between randomisation and 7 days
measure: Change from baseline to peak creatinine
timeFrame: Between randomisation and 14 days
measure: Angioedema
timeFrame: Between randomisation and end of study day 12
measure: Change from baseline AST, ALT and bilirubin
timeFrame: Between randomisation and 14 days
Locations:
city: Jacksonville
country: United States
facility: University of Florida
state: Florida
city: Augusta
country: United States
facility: Augusta University
state: Georgia
city: Chicago
country: United States
facility: University of Illinois Health
state: Illinois
city: New Orleans
country: United States
facility: Tulane Medical Center
state: Louisiana
city: Ann Arbor
country: United States
facility: University of Michigan
state: Michigan
city: New York
country: United States
facility: Memorial Sloan Kettering Cancer Center
state: New York
city: Winston-Salem
country: United States
facility: Wake Forest Baptist Health
state: North Carolina
city: Columbus
country: United States
facility: The Ohio State University Wexner Medical Center
state: Ohio
city: Portland
country: United States
facility: Oregon Health and Science University
state: Oregon
city: Pittsburgh
country: United States
facility: University of Pittsburgh Medical Centre
state: Pennsylvania
city: Providence
country: United States
facility: Brown University - Rhode Island Hospital
state: Rhode Island
city: Canberra
country: Australia
facility: Canberra Hospital
state: Australian Capital Territory
city: Bankstown
country: Australia
facility: Bankstown-Lidcombe Hospital
state: New South Wales
city: Blacktown
country: Australia
facility: Blacktown Hospital
state: New South Wales
city: Campbelltown
country: Australia
facility: Campbelltown Hospital
state: New South Wales
city: Caringbah
country: Australia
facility: Sutherland Hospital
state: New South Wales
city: Concord
country: Australia
facility: Concord Hospital
state: New South Wales
city: Dubbo
country: Australia
facility: Dubbo Base Hospital
state: New South Wales
city: Frenchs Forest
country: Australia
facility: Northern Beaches Hospital
state: New South Wales
city: Kingswood
country: Australia
facility: Nepean Hospital
state: New South Wales
city: Kogarah
country: Australia
facility: St. George Hospital
state: New South Wales
city: Liverpool
country: Australia
facility: Liverpool Hospital
state: New South Wales
city: Newcastle
country: Australia
facility: John Hunter Hospital
state: New South Wales
city: Orange
country: Australia
facility: Orange Health Service
state: New South Wales
city: Sydney
country: Australia
facility: St Vincent's Hospital Sydney
state: New South Wales
city: Sydney
country: Australia
facility: Prince of Wales Hospital
state: New South Wales
city: Sydney
country: Australia
facility: Royal Prince Alfred Hospital
state: New South Wales
city: Sydney
country: Australia
facility: Royal North Shore Hospital
state: New South Wales
city: Sydney
country: Australia
facility: Wollongong Hospital
state: New South Wales
city: Wagga Wagga
country: Australia
facility: Wagga Wagga Base Hospital
state: New South Wales
city: Westmead
country: Australia
facility: Westmead Hospital
state: New South Wales
city: Darwin
country: Australia
facility: Royal Darwin Hospital,
state: Northern Territory
city: Birtinya
country: Australia
facility: Sunshine Coast University Hospital
state: Queensland
city: Brisbane
country: Australia
facility: The Prince Charles Hospital
state: Queensland
city: Brisbane
country: Australia
facility: Mater Hospital Brisbane
state: Queensland
city: Brisbane
country: Australia
facility: Princess Alexandra Hospital
state: Queensland
city: Caboolture
country: Australia
facility: Caboolture Hospital
state: Queensland
city: Coopers Plains
country: Australia
facility: Queen Elizabeth II Jubilee Hospital
state: Queensland
city: Logan
country: Australia
facility: Logan Hospital
state: Queensland
city: Redcliffe
country: Australia
facility: Redcliffe Hospital
state: Queensland
city: Rockhampton
country: Australia
facility: Rockhampton Hospital
state: Queensland
city: Southport
country: Australia
facility: Gold Coast University Hospital
state: Queensland
city: Toowoomba
country: Australia
facility: Toowoomba Hospital
state: Queensland
city: Townsville
country: Australia
facility: Townsville Hospital
state: Queensland
city: Adelaide
country: Australia
facility: Royal Adelaide Hospital
state: South Australia
city: Adelaide
country: Australia
facility: The Queen Elizabeth Hospital
state: South Australia
city: Adelaide
country: Australia
facility: Lyell McEwin Hospital
state: South Australia
city: Bedford Park
country: Australia
facility: Flinders Medical Centre
state: South Australia
city: Launceston
country: Australia
facility: Launceston Hospital
state: Tasmania
city: Ballarat
country: Australia
facility: Ballarat Base Hospital
state: Victoria
city: Bendigo
country: Australia
facility: Bendigo Hospital
state: Victoria
city: Berwick
country: Australia
facility: Casey Hospital
state: Victoria
city: Box Hill
country: Australia
facility: Box Hill Hospital
state: Victoria
city: Clayton
country: Australia
facility: Monash Medical Centre
state: Victoria
city: Dandenong
country: Australia
facility: Dandenong Hospital
state: Victoria
city: Ferntree Gully
country: Australia
facility: Angliss Hospital
state: Victoria
city: Footscray
country: Australia
facility: Footscray Hospital
state: Victoria
city: Geelong
country: Australia
facility: University Hosptial Geelong
state: Victoria
city: Melbourne
country: Australia
facility: The Alfred Hospital
state: Victoria
city: Melbourne
country: Australia
facility: Royal Melbourne Hospital
state: Victoria
city: Melbourne
country: Australia
facility: St Vincent's Hospital Melbourne
state: Victoria
city: Ringwood East
country: Australia
facility: Maroondah Hospital
state: Victoria
city: Sunshine
country: Australia
facility: Sunshine Hospital
state: Victoria
city: Werribee
country: Australia
facility: Werribee Mercy Hospital
state: Victoria
city: Midland
country: Australia
facility: St John of God Hospital Midland
state: Western Australia
city: Murdoch
country: Australia
facility: St John of God Hospital Murdoch
state: Western Australia
city: Perth
country: Australia
facility: Royal Perth Hospital
state: Western Australia
city: Perth
country: Australia
facility: Sir Charles Gairdner Hospital
state: Western Australia
city: Perth
country: Australia
facility: Fiona Stanley Hospital
state: Western Australia
city: Subiaco
country: Australia
facility: St John of God Subiaco
state: Western Australia
city: Charleroi
country: Belgium
facility: CHU de Charleroi - Hôpital Civil Marie Curie
city: Gent
country: Belgium
facility: Universitair Ziekenhuis Gent
city: Namur
country: Belgium
facility: CHU Namur site Godinne
city: Calgary
country: Canada
facility: Foothills Medical Centre
state: Alberta
city: Calgary
country: Canada
facility: Peter Lougheed Centre
state: Alberta
city: Calgary
country: Canada
facility: Rockyview General Hospital
state: Alberta
city: Calgary
country: Canada
facility: South Health Campus
state: Alberta
city: Edmonton
country: Canada
facility: Royal Alexandra Hospital, Alberta
state: Alberta
city: Edmonton
country: Canada
facility: University of Alberta Hospital
state: Alberta
city: Surrey
country: Canada
facility: Surrey Memorial Hospital
state: British Columbia
city: Winnipeg
country: Canada
facility: St Boniface General Hospital
state: Manitoba
city: Winnipeg
country: Canada
facility: Health Sciences Centre Winnipeg
state: Manitoba
city: Winnipeg
country: Canada
facility: Grace Hospital
state: Manitoba
city: Fredericton
country: Canada
facility: Dr. Everett Chalmers Regional Hospital
state: New Brunswick
city: Fredericton
country: Canada
facility: The Moncton Hospital
state: New Brunswick
city: Fredericton
country: Canada
facility: The Saint John General Hospital
state: New Brunswick
city: Brampton
country: Canada
facility: William Osler Health System
state: Ontario
city: Brantford
country: Canada
facility: Brantford General Hospital
state: Ontario
city: Hamilton
country: Canada
facility: Hamilton general Hospital
state: Ontario
city: Hamilton
country: Canada
facility: Juravinski Hospital
state: Ontario
city: Hamilton
country: Canada
facility: St. Joseph's Healthcare Hamilton
state: Ontario
city: Kingston
country: Canada
facility: Kingston Health Sciences Centre
state: Ontario
city: Kitchener
country: Canada
facility: Grand River Hospital
state: Ontario
city: Kitchener
country: Canada
facility: St Mary's General Hospital
state: Ontario
city: Ottawa
country: Canada
facility: The Ottawa Hospital
state: Ontario
city: Saint Catharines
country: Canada
facility: Niagara Health
state: Ontario
city: Thunder Bay
country: Canada
facility: Thunder Bay General Hospital
state: Ontario
city: Toronto
country: Canada
facility: Sunnybrook Health Sciences Centre
state: Ontario
city: Toronto
country: Canada
facility: St. Michael's Hospital Unity Health Toronto
state: Ontario
city: Toronto
country: Canada
facility: Mount Sinai Hospital
state: Ontario
city: Toronto
country: Canada
facility: Toronto General Hospital
state: Ontario
city: Toronto
country: Canada
facility: Toronto Western Hospital
state: Ontario
city: Toronto
country: Canada
facility: St Joseph's Health Centre
state: Ontario
city: Lévis
country: Canada
facility: CIUSS Chaudieres-Appalaches (Levis)
state: Quebec
city: Montréal
country: Canada
facility: Hospital Maisonneuve-Rosemont
state: Quebec
city: Montréal
country: Canada
facility: Hôpital Fleury
state: Quebec
city: Montréal
country: Canada
facility: Centre Hospitalier de l'Universite de Montreal
state: Quebec
city: Montréal
country: Canada
facility: McGill University Health Centre
state: Quebec
city: Montréal
country: Canada
facility: Hopital du Sacre-Coeur de Montreal
state: Quebec
city: Québec
country: Canada
facility: CHU de Québec - Université Laval
state: Quebec
city: Québec
country: Canada
facility: IUCPQ-UL
state: Quebec
city: Sherbrooke
country: Canada
facility: Centre Hospitalier de l'Université de Sherbrooke
state: Quebec
city: Saskatoon
country: Canada
facility: Regina General Hospital
state: Saskatchewan
city: Chía
country: Colombia
facility: Universidad de La Sabana
state: Cundinamarca
city: Požega
country: Croatia
facility: General County Hospital Požega
city: Zagreb
country: Croatia
facility: University Hospital Centre Zagreb
city: Zagreb
country: Croatia
facility: University Hospital for Infectious Diseases
city: Prague
country: Czechia
facility: Fakultní nemocnice Královské Vinohrady
city: Teplice
country: Czechia
facility: Teplice Hospital
city: Tartu
country: Estonia
facility: Tartu University Hospital
city: Helsinki
country: Finland
facility: Helsinki University Hospital
city: Tampere
country: Finland
facility: Tampere University Hospital
city: Argenteuil
country: France
facility: CH Argenteuil
city: Aurillac
country: France
facility: Centre Hospitalier Henri Mondor d'Aurillac
city: Beauvais
country: France
facility: Beauvais General Hospital
city: Belfort
country: France
facility: Hopital Nord Franche-Comte
city: Boulogne-Billancourt
country: France
facility: Ambroise Pare Hospital
city: Béthune
country: France
facility: Centre hospitalier Bethune Beuvry
city: Dax
country: France
facility: CH de Dax
city: Dieppe
country: France
facility: Centre Hospitalier de Dieppe
city: Dijon
country: France
facility: CHU Dijon Bourgogne
city: Eaubonne
country: France
facility: Hopital Simone Veil Eaubonne
city: Garches
country: France
facility: Hospital Raymond Poincare
city: La Roche-sur-Yon
country: France
facility: CHD Vendee
city: Le Mans
country: France
facility: Centre Hospitalier Le Mans
city: Limoges
country: France
facility: CHU Dupuytren
city: Melun
country: France
facility: Centre Hospitalier de Melun
city: Mont-de-Marsan
country: France
facility: Centre Hospitalier Layne - Mont-de-Marsan
city: Morlaix
country: France
facility: Centre Hospitalier des Pays de Morlaix
city: Orléans
country: France
facility: CHR d'Orleans
city: Paris
country: France
facility: Lariboisiere Hospital
city: Paris
country: France
facility: Hopital Tenon
city: Strasbourg
country: France
facility: Nouvel Hopital Civil Strasbourg
city: Strasbourg
country: France
facility: Hopital de Hautepierre Strasbourg
city: Tours
country: France
facility: CHRU Tours Hopital Bretonneau
city: Étampes
country: France
facility: Sud Essonne Hospital Etampes
city: Berlin
country: Germany
facility: Charité - Universitätsmedizin Berlin - Infektiologie und Pneumologie
city: Berlin
country: Germany
facility: Vivantes Klinikum Neukölln
city: Berlin
country: Germany
facility: Charite Universitätsmedizin Berlin
city: Berlin
country: Germany
facility: Vivantes Humboldt-Klinikum
city: Cottbus
country: Germany
facility: Carl-Thiem-Klinikum Cottbus
city: Dortmund
country: Germany
facility: Klinikum Dortmund
city: Essen
country: Germany
facility: Elisabeth Hospital Essen
city: Frankfurt
country: Germany
facility: Universitätsklinikum Frankfurt
city: Hamburg
country: Germany
facility: University Medical Center Hamburg-Eppendorf (UKE)
city: Jena
country: Germany
facility: Universitätsklinikum Jena
city: Köln
country: Germany
facility: University Hospital of Cologne
city: Leipzig
country: Germany
facility: University Hospital Leipzig
city: Leipzig
country: Germany
facility: Universitätsklinikum Leipzig
city: München
country: Germany
facility: Klinikum rechts der Isar der TU München
city: Münster
country: Germany
facility: Universitätsklinikum Münster
city: Tübingen
country: Germany
facility: Universitäts Klinikum Tübingen
city: Würzburg
country: Germany
facility: Universitätsklinikum Würzburg
city: Nyíregyháza
country: Hungary
facility: Jósa András County Hospital
city: Ózd
country: Hungary
facility: Almási Balogh Pál Kórház
city: Chennai
country: India
facility: Apollo Main Hospital
state: Tamil Nadu
city: Chennai
country: India
facility: Apollo First Med Hospital
state: Tamil Nadu
city: Chennai
country: India
facility: Apollo Vanagaram Hospital
state: Tamil Nadu
city: Chennai
country: India
facility: Apollo Speciality Hospital - OMR
state: Tamil Nadu
city: Cork
country: Ireland
facility: Cork University Hospital
city: Dublin
country: Ireland
facility: Beaumont Hospital
city: Dublin
country: Ireland
facility: St. Vincent's University Hospital
city: Galway
country: Ireland
facility: University Hospital Galway
city: Waterford
country: Ireland
facility: University Hospital Waterford
city: Haifa
country: Israel
facility: Rambam Medical Center
city: Petah-Tikva
country: Israel
facility: Beilinson Hospital, Rabin Medical Center
city: Poriyya
country: Israel
facility: The Baruch Padeh Medical Center
city: Brescia
country: Italy
facility: AO Spedali Civili di Brescia
city: Milan
country: Italy
facility: Humanitas Research Hospital
city: Milan
country: Italy
facility: Ca' Granda Ospedale Maggiore Policlinico
city: Milan
country: Italy
facility: IRCCS Ospedale San Raffaele
city: Palermo
country: Italy
facility: Azienda Ospedaliera Universitaria Policlinico Paolo Giaccone
city: Palermo
country: Italy
facility: Istituto Mediterraneo per i Trapianti e Terapie ad alta specializzazione
city: Reggio Emilia
country: Italy
facility: Arcispedale S. Maria Nuova
city: Rimini
country: Italy
facility: Ospedale Infermi di Rimini
city: Kawasaki
country: Japan
facility: St Marianna University School of Medicine
state: Kanagawa
city: Yokohama
country: Japan
facility: Yokohama City University Hospital
state: Kanagawa
city: Yokohama
country: Japan
facility: St. Marianna University Yokohama City Seibu Hospital
state: Kanagawa
city: Minami
country: Japan
facility: Saiseikai Kumamoto Hospital
state: Kumamoto
city: Osaka
country: Japan
facility: Osaka City General Hospital
city: Tokyo
country: Japan
facility: Nerima Hikarigaoka Hospital
city: Tokyo
country: Japan
facility: Tokyo Metropolitan Bokutoh Hospital
city: Tokyo
country: Japan
facility: Itabashi Chuo Medical Center
city: Tokyo
country: Japan
facility: Tokyo bay Urayasu-Ichikawa Medical Center
city: Wakayama
country: Japan
facility: Wakayama Medical University
city: Bharatpur
country: Nepal
facility: Chitwan Medical College
city: Kathmandu
country: Nepal
facility: Grande International Hospital
city: Kathmandu
country: Nepal
facility: Hospital for Advanced Medicine and Surgery (HAMS)
city: Kathmandu
country: Nepal
facility: Nepal Mediciti
city: Almelo
country: Netherlands
facility: ZGT Almelo
city: Amersfoort
country: Netherlands
facility: Meander Medisch Centrum
city: Amsterdam
country: Netherlands
facility: OLVG
city: Arnhem
country: Netherlands
facility: Rijnstate Hospital
city: Den Bosch
country: Netherlands
facility: Jeroen Bosch Ziekenhuis
city: Den Haag
country: Netherlands
facility: Hagaziekenhuis
city: Deventer
country: Netherlands
facility: Deventer Hospital
city: Ede
country: Netherlands
facility: Ziekenhuis Gelderse Vallei
city: Eindhoven
country: Netherlands
facility: Maxima Medisch Centrum Eindhoven
city: Groningen
country: Netherlands
facility: Martini Hospital Groningen
city: Groningen
country: Netherlands
facility: University Medical Center Groningen
city: Leeuwarden
country: Netherlands
facility: Medisch Centrum Leeuwarden
city: Leiden
country: Netherlands
facility: Leiden University Medical Center
city: Nijmegen
country: Netherlands
facility: Canisius Wilhelmina Ziekenhuis
city: Nijmegen
country: Netherlands
facility: Radboud University Medical Center
city: Roermond
country: Netherlands
facility: Laurentius Hospital
city: Rotterdam
country: Netherlands
facility: Maasstad Ziekenhuis
city: Uden
country: Netherlands
facility: Bernhoven Hospital
city: Utrecht
country: Netherlands
facility: University Medical Center Utrecht
city: Auckland
country: New Zealand
facility: North Shore Hospital
city: Auckland
country: New Zealand
facility: CVICU, Auckland City Hospital
city: Auckland
country: New Zealand
facility: DCCM, Auckland City Hospital
city: Auckland
country: New Zealand
facility: Middlemore Hospital
city: Christchurch
country: New Zealand
facility: Christchurch Hospital
city: Hamilton
country: New Zealand
facility: Waikato Hospital
city: New Plymouth
country: New Zealand
facility: Taranaki Base Hospital
city: Rotorua
country: New Zealand
facility: Rotorua Hospital
city: Tauranga
country: New Zealand
facility: Tauranga Hospital
city: Wellington
country: New Zealand
facility: Wellington Regional Hospital
city: Whangarei
country: New Zealand
facility: Whangarei Hospital
city: Karachi
country: Pakistan
facility: Ziauddin University Hospital Clifton Campus
state: Sindh
city: Karachi
country: Pakistan
facility: Abbasi Shaheed Hospital
state: Sindh
city: Karachi
country: Pakistan
facility: National Institute of Cardiovascular Diseases, Karachi
state: Sindh
city: Karachi
country: Pakistan
facility: South City Hospital, Karachi
state: Sindh
city: Karachi
country: Pakistan
facility: Ziauddin University North Nazimabad Campus
state: Sindh
city: Abrantes
country: Portugal
facility: Centro Hospitalar do Medio Tejo
city: Lisboa
country: Portugal
facility: Hospital Ocidental
city: Lisboa
country: Portugal
facility: Hospital Lusíadas Lisbon
city: Bucharest
country: Romania
facility: Clinical Hospital of Infectious and Tropical Diseases "Dr. Victor Babes"
city: Riyadh
country: Saudi Arabia
facility: King Abdulaziz Medical City
city: Belgrade
country: Serbia
facility: University Hospital Center Dr Dragiša Mišović
city: Belgrad
country: Serbia
facility: University Clinical Centre of Serbia
city: Niš
country: Serbia
facility: Clinical Centre of Niš
city: Golnik
country: Slovenia
facility: University Clinic of Respiratory and Allergic Diseases Golnik
city: Maribor
country: Slovenia
facility: University Medical Centre Maribor
city: Barcelona
country: Spain
facility: Hospital del Mar
city: Cadiz
country: Spain
facility: Hospital Universitario de Jerez
city: Córdoba
country: Spain
facility: Reina Sofia University Hospital
city: Madrid
country: Spain
facility: Ramon y Cajal University Hospital
city: Málaga
country: Spain
facility: Hospital Regional de Málaga
city: Ourense
country: Spain
facility: Hospital Universitario de Ourense
city: Santander
country: Spain
facility: Hospital Marqués de Valdecilla
city: Tortosa
country: Spain
facility: Hospital Verge de la Cinta
city: Valencia
country: Spain
facility: Doctor Peset University Hospital
city: Valencia
country: Spain
facility: Hospital La Fe
city: Zürich
country: Switzerland
facility: University Hospital Zürich
city: Basildon
country: United Kingdom
facility: Basildon Hospital
state: England
city: Basingstoke
country: United Kingdom
facility: Basingstoke and North Hampshire Hospital
state: England
city: Bath
country: United Kingdom
facility: Royal United Hospital, Bath
state: England
city: Birmingham
country: United Kingdom
facility: Queen Elizabeth Hospital Birmingham
state: England
city: Birmingham
country: United Kingdom
facility: Birmingham City Hospital
state: England
city: Blackburn
country: United Kingdom
facility: Royal Blackburn Teaching Hospital
state: England
city: Boston
country: United Kingdom
facility: Pilgrim Hospital ULHT
state: England
city: Bournemouth
country: United Kingdom
facility: Royal Bournemouth Hospital
state: England
city: Brighton
country: United Kingdom
facility: Royal Sussex County Hospital
state: England
city: Bristol
country: United Kingdom
facility: Southmead Hospital
state: England
city: Bristol
country: United Kingdom
facility: Bristol Royal Infirmary
state: England
city: Burton on Trent
country: United Kingdom
facility: Queen's Hospital, Burton
state: England
city: Cambridge
country: United Kingdom
facility: Royal Papworth Hospital
state: England
city: Cambridge
country: United Kingdom
facility: Addenbrookes Hospital
state: England
city: Carlisle
country: United Kingdom
facility: North Cumberland Infirmary
state: England
city: Chertsey
country: United Kingdom
facility: St Peter's Hospital
state: England
city: Chesterfield
country: United Kingdom
facility: Chesterfield Royal Hospital
state: England
city: Chester
country: United Kingdom
facility: Countess of Chester Hospital
state: England
city: Colchester
country: United Kingdom
facility: Colchester Hospital
state: England
city: Coventry
country: United Kingdom
facility: University Hospital Coventry
state: England
city: Darlington
country: United Kingdom
facility: Darlington Memorial Hospital
state: England
city: Dartford
country: United Kingdom
facility: Darent Valley Hospital
state: England
city: Dudley
country: United Kingdom
facility: Russells Hall Hospital
state: England
city: Exeter
country: United Kingdom
facility: Royal Devon and Exeter Hospital
state: England
city: Frimley
country: United Kingdom
facility: Frimley Park Hospital
state: England
city: Gateshead
country: United Kingdom
facility: Queen Elizabeth Hospital Gateshead
state: England
city: Gillingham
country: United Kingdom
facility: Medway Maritime Hospital
state: England
city: Great Yarmouth
country: United Kingdom
facility: James Paget University Hospital
state: England
city: Guildford
country: United Kingdom
facility: Royal Surrey County Hospital
state: England
city: Harrow
country: United Kingdom
facility: Northwick Park Hospital
state: England
city: Hereford
country: United Kingdom
facility: Hereford County Hospital
state: England
city: High Barnet
country: United Kingdom
facility: Barnet Hospital
state: England
city: Huddersfield
country: United Kingdom
facility: Huddersfield Royal Infirmary
state: England
city: Ilford
country: United Kingdom
facility: King George Hospital
state: England
city: Ipswich
country: United Kingdom
facility: Ipswich Hospital
state: England
city: Kettering
country: United Kingdom
facility: Kettering Hospital
state: England
city: Leeds
country: United Kingdom
facility: Leeds General Infirmary
state: England
city: Leicester
country: United Kingdom
facility: Leicester Royal Infirmary
state: England
city: Leicester
country: United Kingdom
facility: Glenfield Hospital
state: England
city: Lincoln
country: United Kingdom
facility: Lincoln County Hospital
state: England
city: Liverpool
country: United Kingdom
facility: Liverpool Heart and Chest Hospital
state: England
city: Liverpool
country: United Kingdom
facility: Alder Hey Hospital
state: England
city: Liverpool
country: United Kingdom
facility: Royal Liverpool University Hospital
state: England
city: Liverpool
country: United Kingdom
facility: University Hospital Aintree
state: England
city: London
country: United Kingdom
facility: Croydon University Hospital
state: England
city: London
country: United Kingdom
facility: Royal London Hospital
state: England
city: London
country: United Kingdom
facility: Whipps Cross Hospital
state: England
city: London
country: United Kingdom
facility: Newham University Hospital
state: England
city: London
country: United Kingdom
facility: St Bartholomew's Hospital
state: England
city: London
country: United Kingdom
facility: North Middlesex University Hospital
state: England
city: London
country: United Kingdom
facility: Royal Free Hospital
state: England
city: London
country: United Kingdom
facility: St Thomas Hospital
state: England
city: London
country: United Kingdom
facility: Guy's Hospital
state: England
city: London
country: United Kingdom
facility: Queen Elizabeth Hospital, Woolwich
state: England
city: London
country: United Kingdom
facility: King's College Hospital
state: England
city: London
country: United Kingdom
facility: St George's University Hospital
state: England
city: London
country: United Kingdom
facility: Royal Marsden Hospital
state: England
city: London
country: United Kingdom
facility: Royal Brompton Hospital
state: England
city: London
country: United Kingdom
facility: Hammersmith Hospital
state: England
city: London
country: United Kingdom
facility: St Mary's Hospital
state: England
city: London
country: United Kingdom
facility: Charing Cross Hospital
state: England
city: Luton
country: United Kingdom
facility: Luton and Dunstable University Hospital
state: England
city: Maidstone
country: United Kingdom
facility: Maidstone Hospital
state: England
city: Manchester
country: United Kingdom
facility: Manchester Royal Infirmary
state: England
city: Manchester
country: United Kingdom
facility: The Christie Hospital
state: England
city: Manchester
country: United Kingdom
facility: Wythenshawe Hospital
state: England
city: Manchester
country: United Kingdom
facility: North Manchester General Hospital
state: England
city: Middlesbrough
country: United Kingdom
facility: The James Cook University Hospital
state: England
city: Milton Keynes
country: United Kingdom
facility: Milton Keynes University Hospital
state: England
city: Newcastle
country: United Kingdom
facility: Royal Victoria Infirmary, Newcastle
state: England
city: Newcastle
country: United Kingdom
facility: Newcastle Freeman Hospital
state: England
city: Northampton
country: United Kingdom
facility: Northampton General Hospital
state: England
city: Norwich
country: United Kingdom
facility: Norfolk and Norwich University Hospital
state: England
city: Nottingham
country: United Kingdom
facility: City Hospital Nottingham
state: England
city: Nottingham
country: United Kingdom
facility: Queen's Medical Centre - Nottingham University Hospitals NHS Trust
state: England
city: Nuneaton
country: United Kingdom
facility: George Eliot Hospital
state: England
city: Oldham
country: United Kingdom
facility: Royal Oldham Hospital
state: England
city: Orpington
country: United Kingdom
facility: Princess Royal University Hospital
state: England
city: Oxford
country: United Kingdom
facility: John Radcliffe Hospital
state: England
city: Plymouth
country: United Kingdom
facility: Derriford Hospital
state: England
city: Poole
country: United Kingdom
facility: Poole Hospital NHS Foundation Trust
state: England
city: Portsmouth
country: United Kingdom
facility: Queen Alexandra Hospital
state: England
city: Prescot
country: United Kingdom
facility: Whiston Hospital
state: England
city: Preston
country: United Kingdom
facility: Royal Preston Hospital
state: England
city: Reading
country: United Kingdom
facility: Royal Berkshire Hospital
state: England
city: Redditch
country: United Kingdom
facility: Alexandra Hospital, Redditch
state: England
city: Romford
country: United Kingdom
facility: Queen's Hospital Romford
state: England
city: Rotherham
country: United Kingdom
facility: Rotherham Hospital
state: England
city: Salford
country: United Kingdom
facility: Salford Royal Hospital
state: England
city: Salisbury
country: United Kingdom
facility: Salisbury District Hospital
state: England
city: Sheffield
country: United Kingdom
facility: Royal Hallamshire Hospital
state: England
city: Sheffield
country: United Kingdom
facility: Northern General Hospital
state: England
city: Slough
country: United Kingdom
facility: Wexham Park Hospital
state: England
city: South Shields
country: United Kingdom
facility: South Tyneside District Hospital
state: England
city: Southampton
country: United Kingdom
facility: Southampton General Hospital
state: England
city: Stockport
country: United Kingdom
facility: Stepping Hill Hospital
state: England
city: Stockton-on-Tees
country: United Kingdom
facility: University Hospital of North Tees
state: England
city: Stoke-on-Trent
country: United Kingdom
facility: Royal Stoke University Hospital
state: England
city: Sunderland
country: United Kingdom
facility: Sunderland Royal Hospital
state: England
city: Sutton In Ashfield
country: United Kingdom
facility: King's Mill Hospital
state: England
city: Swindon
country: United Kingdom
facility: Great Western Hospital
state: England
city: Swindon
country: United Kingdom
facility: Western General Hospital
state: England
city: Taunton
country: United Kingdom
facility: Musgrove Park Hospital
state: England
city: Torquay
country: United Kingdom
facility: Torbay Hospital
state: England
city: Truro
country: United Kingdom
facility: Royal Cornwall Hospital
state: England
city: Tunbridge Wells
country: United Kingdom
facility: Tunbridge Wells Hospital - Maidstone and Tunbridge Wells NHS Trust
state: England
city: Uxbridge
country: United Kingdom
facility: Harefield Hospital
state: England
city: Watford
country: United Kingdom
facility: Watford General Hospital
state: England
city: Westcliff-on-Sea
country: United Kingdom
facility: Southend Hospital
state: England
city: Whitehaven
country: United Kingdom
facility: West Cumberland Hospital
state: England
city: Wigan
country: United Kingdom
facility: Royal Albert Edward Infirmary
state: England
city: Winchester
country: United Kingdom
facility: Royal Hampshire County Hospital
state: England
city: Wirral
country: United Kingdom
facility: Arrowe Park Hospital
state: England
city: Wolverhampton
country: United Kingdom
facility: New Cross Hospital Wolverhampton
state: England
city: Worcester
country: United Kingdom
facility: Worcestershire Royal Hospital
state: England
city: York
country: United Kingdom
facility: York Teaching Hospital
state: England
city: Antrim
country: United Kingdom
facility: Antrim Area Hospital
state: Northern Ireland
city: Belfast
country: United Kingdom
facility: Royal Victoria Hospital Belfast
state: Northern Ireland
city: Belfast
country: United Kingdom
facility: Mater Hospital
state: Northern Ireland
city: Belfast
country: United Kingdom
facility: Belfast City Hospital
state: Northern Ireland
city: Derry
country: United Kingdom
facility: Altnagelvin Hospital
state: Northern Ireland
city: Aberdeen
country: United Kingdom
facility: Aberdeen Royal Infirmary
state: Scotland
city: Dundee
country: United Kingdom
facility: Ninewells Hospital
state: Scotland
city: Edinburgh
country: United Kingdom
facility: Royal Infirmary of Edinburgh
state: Scotland
city: Glasgow
country: United Kingdom
facility: Glasgow Royal Infirmary
state: Scotland
city: Glasgow
country: United Kingdom
facility: Queen Elizabeth University Hospital, Glasgow
state: Scotland
city: Paisley
country: United Kingdom
facility: Royal Alexandra Hospital
state: Scotland
city: Abergavenny
country: United Kingdom
facility: Neville Hall Hospital
state: Wales
city: Bodelwyddan
country: United Kingdom
facility: Glan Clwyd Hospital
state: Wales
city: Bridgend
country: United Kingdom
facility: Princess of Wales Hospital
state: Wales
city: Cardiff
country: United Kingdom
facility: Cardiff and Vale University Hospital Wales
state: Wales
city: Carmarthen
country: United Kingdom
facility: Glangwilli Hospital
state: Wales
city: Cwmbran
country: United Kingdom
facility: Grange University Hospital
state: Wales
city: Newport
country: United Kingdom
facility: Royal Gwent Hospital
state: Wales
city: Pontyclun
country: United Kingdom
facility: Royal Glamorgan Hospital
state: Wales
city: Swansea
country: United Kingdom
facility: Morriston Hospital
state: Wales
city: Wrexham
country: United Kingdom
facility: Wrexham Maelor Hospital
state: Wales
city: Belfast
country: United Kingdom
facility: Ulster Hospital
city: Bristol
country: United Kingdom
facility: Bristol Royal Childrens Hospital
city: Bury
country: United Kingdom
facility: Fairfield General Hospital
city: Crewe
country: United Kingdom
facility: Leighton Hospital
city: Dorchester
country: United Kingdom
facility: Dorset County Hospital
city: Gloucester
country: United Kingdom
facility: Gloucester Royal Hospital
city: Haywards Heath
country: United Kingdom
facility: The Princess Royal Hospital Haywards Heath
city: Leeds
country: United Kingdom
facility: St. James University Hospital
city: London
country: United Kingdom
facility: Homerton Hospital
city: London
country: United Kingdom
facility: University College London Hospital
city: London
country: United Kingdom
facility: Chelsea and Westminster Hospital
city: Margate
country: United Kingdom
facility: Queen Elizabeth and Queen Mother Hospital
city: Newcastle Upon Tyne
country: United Kingdom
facility: Newcastle Royal Victoria Infirmary (Paediatrics)
city: North Shields
country: United Kingdom
facility: North Tyneside General Hospital
city: Warwick
country: United Kingdom
facility: Warwick Hospital
city: West Bromwich
country: United Kingdom
facility: Sandwell General Hospital
Study officials:
affiliation: Monash University, Study Chair REMAP-CAP Australia
name: Steve Webb, Prof
role: STUDY_CHAIR
affiliation: Medical Research Institute of New Zealand, Study Chair REMAP-CAP New Zealand
name: Colin McArthur, Dr
role: STUDY_CHAIR
affiliation: UMC Utrecht, Study Chair REMAP-CAP Europe
name: Marc Bonten, Prof
role: STUDY_CHAIR
affiliation: UMC Utrecht, Coordinating Investigator REMAP-CAP Europe
name: Lennie Derde, MD
role: STUDY_CHAIR
affiliation: Unity Health Toronto, Study Chair REMAP-CAP Canada
name: John Marshall, Prof
role: STUDY_CHAIR
affiliation: University of Pittsburgh Medical Center, Study Chair REMAP-CAP USA
name: Derek Angus, Prof
role: STUDY_CHAIR
References:
citation: REMAP-CAP Writing Committee for the REMAP-CAP Investigators; Bradbury CA, Lawler PR, Stanworth SJ, McVerry BJ, McQuilten Z, Higgins AM, Mouncey PR, Al-Beidh F, Rowan KM, Berry LR, Lorenzi E, Zarychanski R, Arabi YM, Annane D, Beane A, van Bentum-Puijk W, Bhimani Z, Bihari S, Bonten MJM, Brunkhorst FM, Buzgau A, Buxton M, Carrier M, Cheng AC, Cove M, Detry MA, Estcourt LJ, Fitzgerald M, Girard TD, Goligher EC, Goossens H, Haniffa R, Hills T, Huang DT, Horvat CM, Hunt BJ, Ichihara N, Lamontagne F, Leavis HL, Linstrum KM, Litton E, Marshall JC, McAuley DF, McGlothlin A, McGuinness SP, Middeldorp S, Montgomery SK, Morpeth SC, Murthy S, Neal MD, Nichol AD, Parke RL, Parker JC, Reyes LF, Saito H, Santos MS, Saunders CT, Serpa-Neto A, Seymour CW, Shankar-Hari M, Singh V, Tolppa T, Turgeon AF, Turner AM, van de Veerdonk FL, Green C, Lewis RJ, Angus DC, McArthur CJ, Berry S, Derde LPG, Webb SA, Gordon AC. Effect of Antiplatelet Therapy on Survival and Organ Support-Free Days in Critically Ill Patients With COVID-19: A Randomized Clinical Trial. JAMA. 2022 Apr 5;327(13):1247-1259. doi: 10.1001/jama.2022.2910.
citation: Writing Committee for the REMAP-CAP Investigators; Estcourt LJ, Turgeon AF, McQuilten ZK, McVerry BJ, Al-Beidh F, Annane D, Arabi YM, Arnold DM, Beane A, Begin P, van Bentum-Puijk W, Berry LR, Bhimani Z, Birchall JE, Bonten MJM, Bradbury CA, Brunkhorst FM, Buxton M, Callum JL, Chasse M, Cheng AC, Cove ME, Daly J, Derde L, Detry MA, De Jong M, Evans A, Fergusson DA, Fish M, Fitzgerald M, Foley C, Goossens H, Gordon AC, Gosbell IB, Green C, Haniffa R, Harvala H, Higgins AM, Hills TE, Hoad VC, Horvat C, Huang DT, Hudson CL, Ichihara N, Laing E, Lamikanra AA, Lamontagne F, Lawler PR, Linstrum K, Litton E, Lorenzi E, MacLennan S, Marshall J, McAuley DF, McDyer JF, McGlothlin A, McGuinness S, Miflin G, Montgomery S, Mouncey PR, Murthy S, Nichol A, Parke R, Parker JC, Priddee N, Purcell DFJ, Reyes LF, Richardson P, Robitaille N, Rowan KM, Rynne J, Saito H, Santos M, Saunders CT, Serpa Neto A, Seymour CW, Silversides JA, Tinmouth AA, Triulzi DJ, Turner AM, van de Veerdonk F, Walsh TS, Wood EM, Berry S, Lewis RJ, Menon DK, McArthur C, Zarychanski R, Angus DC, Webb SA, Roberts DJ, Shankar-Hari M. Effect of Convalescent Plasma on Organ Support-Free Days in Critically Ill Patients With COVID-19: A Randomized Clinical Trial. JAMA. 2021 Nov 2;326(17):1690-1702. doi: 10.1001/jama.2021.18178.
citation: Kreuzberger N, Hirsch C, Chai KL, Tomlinson E, Khosravi Z, Popp M, Neidhardt M, Piechotta V, Salomon S, Valk SJ, Monsef I, Schmaderer C, Wood EM, So-Osman C, Roberts DJ, McQuilten Z, Estcourt LJ, Skoetz N. SARS-CoV-2-neutralising monoclonal antibodies for treatment of COVID-19. Cochrane Database Syst Rev. 2021 Sep 2;9(9):CD013825. doi: 10.1002/14651858.CD013825.pub2.
citation: REMAP-CAP Investigators; ACTIV-4a Investigators; ATTACC Investigators; Goligher EC, Bradbury CA, McVerry BJ, Lawler PR, Berger JS, Gong MN, Carrier M, Reynolds HR, Kumar A, Turgeon AF, Kornblith LZ, Kahn SR, Marshall JC, Kim KS, Houston BL, Derde LPG, Cushman M, Tritschler T, Angus DC, Godoy LC, McQuilten Z, Kirwan BA, Farkouh ME, Brooks MM, Lewis RJ, Berry LR, Lorenzi E, Gordon AC, Ahuja T, Al-Beidh F, Annane D, Arabi YM, Aryal D, Baumann Kreuziger L, Beane A, Bhimani Z, Bihari S, Billett HH, Bond L, Bonten M, Brunkhorst F, Buxton M, Buzgau A, Castellucci LA, Chekuri S, Chen JT, Cheng AC, Chkhikvadze T, Coiffard B, Contreras A, Costantini TW, de Brouwer S, Detry MA, Duggal A, Dzavik V, Effron MB, Eng HF, Escobedo J, Estcourt LJ, Everett BM, Fergusson DA, Fitzgerald M, Fowler RA, Froess JD, Fu Z, Galanaud JP, Galen BT, Gandotra S, Girard TD, Goodman AL, Goossens H, Green C, Greenstein YY, Gross PL, Haniffa R, Hegde SM, Hendrickson CM, Higgins AM, Hindenburg AA, Hope AA, Horowitz JM, Horvat CM, Huang DT, Hudock K, Hunt BJ, Husain M, Hyzy RC, Jacobson JR, Jayakumar D, Keller NM, Khan A, Kim Y, Kindzelski A, King AJ, Knudson MM, Kornblith AE, Kutcher ME, Laffan MA, Lamontagne F, Le Gal G, Leeper CM, Leifer ES, Lim G, Gallego Lima F, Linstrum K, Litton E, Lopez-Sendon J, Lother SA, Marten N, Saud Marinez A, Martinez M, Mateos Garcia E, Mavromichalis S, McAuley DF, McDonald EG, McGlothlin A, McGuinness SP, Middeldorp S, Montgomery SK, Mouncey PR, Murthy S, Nair GB, Nair R, Nichol AD, Nicolau JC, Nunez-Garcia B, Park JJ, Park PK, Parke RL, Parker JC, Parnia S, Paul JD, Pompilio M, Quigley JG, Rosenson RS, Rost NS, Rowan K, Santos FO, Santos M, Santos MO, Satterwhite L, Saunders CT, Schreiber J, Schutgens REG, Seymour CW, Siegal DM, Silva DG Jr, Singhal AB, Slutsky AS, Solvason D, Stanworth SJ, Turner AM, van Bentum-Puijk W, van de Veerdonk FL, van Diepen S, Vazquez-Grande G, Wahid L, Wareham V, Widmer RJ, Wilson JG, Yuriditsky E, Zhong Y, Berry SM, McArthur CJ, Neal MD, Hochman JS, Webb SA, Zarychanski R. Therapeutic Anticoagulation with Heparin in Critically Ill Patients with Covid-19. N Engl J Med. 2021 Aug 26;385(9):777-789. doi: 10.1056/NEJMoa2103417. Epub 2021 Aug 4.
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