Clinical trial NCT04451707: Epidemiology Non-cholera Vibrio Infections
Official title: Multicentre Retrospective Study on the Clinical and Epidemiological Characteristics and Therapeutic Management of Non-cholera Vibrio Infections
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Vibrio Infections
Lead sponsor: Groupe Hospitalier de la Rochelle Ré Aunis
Sponsor class: OTHER
First posted: 2020-06-30
Enrollment: 67
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: RETROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Patients diagnosed with non-cholera Vibrio infection in Western France from 2000 to 2019

Brief summary: The purpose of this study is to identify the epidemiological and clinical characteristics of patients diagnosed with non-cholera Vibrio infection in Western France from 2000 to 2019.

Detailed description: Vibrios are gram-negative, ubiquitous bacteria of the marine flora and are found particularly in warm waters. For example, the incidence is high in Florida and Vibrio infections are now reportable in the United States. Different species of Vibrio are described. A distinction is made between choleric vibrios belonging to serogroups O1 and O139, responsible for cholera epidemics, and non-choleric vibrios. Our study will focus on non-cholera vibrios. Vibrio infections can occur by eating contaminated raw seafood or by exposure of a wound to the marine environment. They occur mainly during the hot summer months. This can be explained on the one hand by higher water temperature and on the other hand by increased beach use. With global warming, it is possible that Vibrio infections may increase in number and location.

Eligibility criteria: Inclusion Criteria:

* non-cholera Vibrio infection

Exclusion Criteria:

* vibriosis to Vibrio cholerae O1 and O139

Primary outcomes:
measure: Number of Participants With Diagnosed Non-cholerae or Non-O1/O139 Vibrio Infection
timeFrame: Up to 20 years, from 2000-2019
Secondary outcomes:
measure: Number of Patients Per Clinical History
timeFrame: at inclusion
measure: Number of Participants Associated With Environmental Factors
timeFrame: at inclusion
measure: Number of Participants Per Identified Species
timeFrame: at inclusion
measure: Number of Participants by Month of the Years
timeFrame: at inclusion
measure: Number of Participants Treated by Antibiotics
timeFrame: through study completion, an average of 1 month
measure: Number of Participants Per Outcome
timeFrame: through study completion, an average of 1 month
Other outcomes:
Locations:
city: Angers
country: France
facility: CHU Angers
city: Bordeaux
country: France
facility: CHU Bordeaux
city: La Roche-sur-Yon
country: France
facility: Centre Hospitalier Départemental de la Vendée
city: Nantes
country: France
facility: CHU Nantes
city: Poitiers
country: France
facility: CHU Poitiers
city: Rennes
country: France
facility: CHU Rennes
city: Tours
country: France
facility: CHU Tours
Study officials:
affiliation: Groupe Hospitalier de la Rochelle Ré Aunis
name: Florence Hoefler, MD
role: STUDY_DIRECTOR
References:
citation: Weis KE, Hammond RM, Hutchinson R, Blackmore CG. Vibrio illness in Florida, 1998-2007. Epidemiol Infect. 2011 Apr;139(4):591-8. doi: 10.1017/S0950268810001354. Epub 2010 Jun 14.
citation: Morris JG Jr. Cholera and other types of vibriosis: a story of human pandemics and oysters on the half shell. Clin Infect Dis. 2003 Jul 15;37(2):272-80. doi: 10.1086/375600. Epub 2003 Jul 3.
citation: Givens CE, Bowers JC, DePaola A, Hollibaugh JT, Jones JL. Occurrence and distribution of Vibrio vulnificus and Vibrio parahaemolyticus--potential roles for fish, oyster, sediment and water. Lett Appl Microbiol. 2014 Jun;58(6):503-10. doi: 10.1111/lam.12226. Epub 2014 Feb 27.
citation: Jones MK, Oliver JD. Vibrio vulnificus: disease and pathogenesis. Infect Immun. 2009 May;77(5):1723-33. doi: 10.1128/IAI.01046-08. Epub 2009 Mar 2. No abstract available.
citation: Hoefler F, Pouget-Abadie X, Roncato-Saberan M, Lemarie R, Takoudju EM, Raffi F, Corvec S, Le Bras M, Cazanave C, Lehours P, Guimard T, Allix-Beguec C. Clinical and Epidemiologic Characteristics and Therapeutic Management of Patients with Vibrio Infections, Bay of Biscay, France, 2001-2019. Emerg Infect Dis. 2022 Dec;28(12):2367-73. doi: 10.3201/eid2812.220748.