Clinical trial NCT02440880: Dexamethasone With TAP Block Increasing the Duration of the Peripheral Nerve Block in Caesarian Section
Official title: Dexamethasone With TAP Block Increasing the Duration of the Peripheral Nerve Block in Caesarian Section
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Pain
Lead sponsor: Cairo University
Sponsor class: OTHER
First posted: 2015-05-12
Enrollment: 150
Sex: FEMALE
Minimum age (years): 18
Maximum age (years): 45
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: Nowadays Cesarean sections became the most popular surgery worldwide with the consumption of the hospital resources and the continuous need to decrease the costs, work load and medical stuff engagement. One of the most common problem is the need to control pain post operatively, this issue increase the work load over the pain management team and increase lead to patient in satisfaction.

This study will test the usage of dexamethasone with different doses (4 and 8 mg) either locally or intravenously (I.V.) with the local anesthetics in TAP (transversus abdominis plane) block to prolong the duration of the block and decrease the need of post-operative analgesics.

Detailed description: Nowadays Cesarean sections became the most popular surgery worldwide with the consumption of the hospital resources and the continuous need to decrease the costs, work load and medical stuff engagement. One of the most common problem is the need to control pain post operatively, this issue increase the work load over the pain management team and increase lead to patient in satisfaction.(1,2,3) The presence of the adjuvant which can be added to the conventional anesthetic medications can prolong the duration of action and decrease the need for frequent post-operative analgesics.(4,5) The idea of adding a catheter or placing an epidural catheter still have a quite limitation regarding the patients compliance, delayed ambulation and high costs, these limitations redirect the anesthetist again to the use of adjuvant with a single shot block to prolong the duration of it and decrease the need of subsequent analgesics.(6) Dexamethasone proved to be an effective adjuvant in prolongation of the nerve blocks with the question regarding the proper route and dose (7,8,9,10).

This study will test the usage of dexamethasone with different doses (4 and 8 mg) either locally or intravenously (I.V.) with the local anesthetics in TAP (transversus abdominis plane) block to prolong the duration of the block and decrease the need of post-operative analgesics.

Eligibility criteria: Inclusion Criteria:

* Any patient ASA (american society of anesthesia) I or II,
* aged between 18 and 45 scheduled for elective cesarean section.

Exclusion Criteria:

* patient refusal,
* age below 18 or above 45 years,
* coagulopathy with INR (international normalized ratio) more than 1.5 or platelets below 100000,
* uncontrolled diabetes, uncontrolled hypertensive, addict patient,
* psychological instability, and
* allergy to the used drugs,
* failure of spinal,
* conversion to general of anesthesia,
* failure of application of TAP block.

Primary outcomes:
measure: level of pain according to verbal analogue scale
timeFrame: THREE DAYS
Secondary outcomes:
Other outcomes:
Locations:
city: Cairo
country: Egypt
facility: Cairo University
state: Giza
Study officials:
affiliation: Anesthesia department, faculty of medicine ,Cairo university
name: Hassan Ali, LECTURER
role: PRINCIPAL_INVESTIGATOR
References: