Clinical trial NCT04712578: Influence of Caffeinated and Non-caffeinated Pre-workout Supplements on Resistance Exercise Performance
Official title: Influence of Caffeinated and Non-caffeinated Pre-workout Supplements on Resistance Exercise Performance
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Resistance Training
Caffeine
Dietary Supplements
Keywords: caffeine
resistance training
resistance exercise
pre-workout supplement
dietary supplements
Lead sponsor: Texas Tech University
Sponsor class: OTHER
Collaborators: name: Legion Athletics, Inc
First posted: 2021-01-15
Enrollment: 24
Sex: ALL
Minimum age (years): 18
Maximum age (years): 40
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: CROSSOVER
Intervention model description: This study is a randomized, double-blind, placebo-controlled crossover trial.
Primary purpose: OTHER

Brief summary: This study is a randomized, double-blind, placebo-controlled crossover trial examining the effects of caffeinated and non-caffeinated pre-workout supplements on resistance exercise performance. Resistance-trained adults will be randomly assigned to complete three study conditions (caffeinated pre-workout, non-caffeinated pre-workout, and placebo) in one of the six possible condition orders. During each condition, participants will report to the laboratory for ingestion of the assigned beverage and subsequent muscular performance testing. Major performance outcomes will be force production variables from a mechanized squat device and maximal strength and muscular endurance on the bench press and leg press exercises.


Eligibility criteria: Inclusion Criteria:

* Between the ages of 18 and 40;
* Body mass between 50 - 100 kg (110-220 lb)
* Generally healthy (defined as an absence of any disease or medical condition which could potentially be negatively affected by consumption of the commercially available dietary supplements or performance of exercise, including but not limited to musculoskeletal or cardiovascular diseases).
* Resistance-trained, defined as completing 2+ resistance training sessions per week for at least three months prior to screening.
* Participants must have reported regular training of the lower body through a multi-joint exercise such as the squat or leg press at least once weekly during the three-month period prior to screening.
* Participants must have reported regular training of the bench press or chest press variation at least once weekly during the three-month period prior to screening.
* Female participants will be required to bench press ≥ 0.5 x body mass and leg press ≥ 1.75 x body mass during initial 1RM assessments to be eligible for this study.
* Male participants will be required to bench press ≥ 1.0 x body mass and leg press ≥ 3.0 x body mass to be eligible.
* Regular caffeine consumption (due to the presence of caffeine in the commercially available dietary supplement). This will be defined as an average self-reported daily intake of 250+ mg of caffeine, which is equivalent to approximately 2.5 cups of coffee.

Exclusion Criteria:

* Failing to meet any of the aforementioned inclusion criteria.
* Pregnant or breastfeeding (for female participants)
* Taking prescription medication which could reasonably make participation unsafe for the participant or influence study outcomes
* An inability to complete resistance exercise due to injury or medical condition
* Self-reported caffeine sensitivity, as indicated by unwanted side effects when caffeine is consumed.
* Allergy to any of the ingredients in the test beverages or standardized breakfast.
* Current use of anabolic steroids
* Presence of a pacemaker or other implanted electrical device.
* Unwillingness to wear the provided surgical mask during all testing procedures.

Primary outcomes:
measure: Isometric Peak Force Production
timeFrame: Approximately 35 minutes after beverage ingestion in each condition.
measure: Isometric Rate of Force Development
timeFrame: Approximately 35 minutes after beverage ingestion in each condition.
measure: Isokinetic Peak Concentric Force Production
timeFrame: Approximately 40 minutes after beverage ingestion in each condition.
measure: Isokinetic Peak Eccentric Force Production
timeFrame: Approximately 40 minutes after beverage ingestion in each condition.
measure: Maximal Strength on Bench Press Exercise
timeFrame: Approximately 65 minutes after beverage ingestion in each condition.
measure: Muscular Endurance on Bench Press Exercise
timeFrame: Approximately 70 minutes after beverage ingestion in each condition.
measure: Maximal Strength on Leg Press Exercise
timeFrame: Approximately 95 minutes after beverage ingestion in each condition.
measure: Muscular Endurance on Leg Press Exercise
timeFrame: Approximately 100 minutes after beverage ingestion in each condition.
Secondary outcomes:
measure: Subjective Ratings of Energy
timeFrame: Five total assessments in each condition. Immediately prior to: beverage ingestion, isometric exercise testing, bench press testing, and leg press testing. Also, immediately after leg press testing.
measure: Subjective Ratings of Focus
timeFrame: Five total assessments in each condition. Immediately prior to: beverage ingestion, isometric exercise testing, bench press testing, and leg press testing. Also, immediately after leg press testing.
measure: Subjective Ratings of Fatigue
timeFrame: Five total assessments in each condition. Immediately prior to: beverage ingestion, isometric exercise testing, bench press testing, and leg press testing. Also, immediately after leg press testing.
Other outcomes:
measure: Participant Identification of Beverage
timeFrame: At the very end of each condition (i.e., approximately 105 minutes after beverage ingestion in each condition; exact time of assessment may vary based on duration of exercise performance testing for each participant).
Locations:
city: Lubbock
country: United States
facility: Department of Kinesiology & Sport Management
state: Texas
Study officials:
References: