Clinical trial NCT06108440: Comparative Effects of Action Observation and Motor Imagery on Upper Limb in Chronic Stroke Patients
Official title: Comparative Effects of Action Observation and Motor Imagery Training on Upper Limb Function in Chronic Stroke Patients
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Stroke
Upper Extremity Paresis
Motor Activity
Keywords: Stroke
Upper Extremity Paresis
Motor Activity
Lead sponsor: Riphah International University
Sponsor class: OTHER
First posted: 2023-10-31
Enrollment: 44
Sex: ALL
Minimum age (years): 40
Maximum age (years): 60
Standard ages: ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Intervention model description: Patients will be divided into Group A (n = 20) and Group B (n = 20) using a randomization through computer generated numbers program. Patients in Group A will receive action observation training with conventional treatment. All participants will undergo the training for 25 minutes per session, 5 days per week for 8 weeks. Patients in Group B will receive motor imagery with conventional treatment. All participants will receive interventions for twenty-five minutes per session, five times a week, for eight weeks.
Primary purpose: TREATMENT

Brief summary: To Compare effects of action observation and motor imagery training on upper limb function in chronic stroke patients.

Detailed description: The study is Randomized controlled trial. The study will be conducted on 44 stroke patients. The study will be conducted in Civil Hospital Shujaabad and Riphah rehabilitation centre Lahore. Patients will be divided into Group A (n = 20) and Group B (n = 20) using a randomization through computer generated numbers program. Patients in Group A will receive action observation training with conventional treatment. All participants will undergo the training for 25 minutes per session, 5 days per week for 8 weeks. Patients in Group B will receive motor imagery with conventional treatment. All participants will receive interventions for twenty-five minutes per session, five times a week, for eight weeks. For the pre- and post-evaluation of all participants, Fugl-Meyer Assessment Upper Extremity (FMA UE) and Wolf Motor Function Test (WMFT) will be used. Data will be analyzed by using SPSS (Statistical package for Social Sciences) 25 version.

Eligibility criteria: Inclusion Criteria:

* Diagnosed with chronic stroke by a neurologist
* 03 months post stroke
* Score 1+ on modified ashworth scale
* Having a score of 24 or higher in the Mini-Mental State Examination

Exclusion Criteria:

* Patient with neurological condition other than stroke e.g. Parkinson's or multiple sclerosis
* Presence of an attached artificial pacemaker
* Presence of a metal implant in the brain
* Presence of visual impairment
* Presence of unilateral neglect in Line bisection test (25)
* Use of antipsychotic drugs

Primary outcomes:
measure: Fugl-Meyer Assessment Upper Extremity (FMA UE):
timeFrame: 6 months
measure: Wolf Motor Function Test (WMFT):
timeFrame: 6 months
Secondary outcomes:
Other outcomes:
Locations:
city: Lahore
country: Pakistan
facility: Riphah International University
state: Fedral
Study officials:
affiliation: Riphah International University
name: Zeest Hashmi, MSNMPT
role: PRINCIPAL_INVESTIGATOR
References:
citation: Demartino AM, Rodrigues LC, Gomes RP, Michaelsen SM. Hand function and type of grasp used by chronic stroke individuals in actual environment. Top Stroke Rehabil. 2019 May;26(4):247-254. doi: 10.1080/10749357.2019.1591037. Epub 2019 Mar 23.
citation: Veldema J, Nowak DA, Gharabaghi A. Resting motor threshold in the course of hand motor recovery after stroke: a systematic review. J Neuroeng Rehabil. 2021 Nov 3;18(1):158. doi: 10.1186/s12984-021-00947-8.
citation: Kuriakose D, Xiao Z. Pathophysiology and Treatment of Stroke: Present Status and Future Perspectives. Int J Mol Sci. 2020 Oct 15;21(20):7609. doi: 10.3390/ijms21207609.
citation: Serlin Y, Shelef I, Knyazer B, Friedman A. Anatomy and physiology of the blood-brain barrier. Semin Cell Dev Biol. 2015 Feb;38:2-6. doi: 10.1016/j.semcdb.2015.01.002. Epub 2015 Feb 11.