louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT06437015: Comparison of CIMT vs Mirror Therapy Effect in Infarcted CVA Patients for Improving Hand Functions
Official title: Comparison of CIMT vs Mirror Therapy Effect in Infarcted CVA Patients for Improving Hand Functions
Study type: INTERVENTIONAL
Overall status: ACTIVE_NOT_RECRUITING
Phase: NA
Conditions: Infected Joint
Lead sponsor: Superior University
Sponsor class: OTHER
First posted: 2024-05-31
Enrollment: 26
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: HEALTH_SERVICES_RESEARCH

Brief summary: CIMT vs Mirror therapy for improving hand function in infarcted CVA patients. Randomized clinical trial study design will be followed. Data will be collected from following centers: Minhaj Physiotherapy Centre, Home visits, Sughra sidiq trust hospital, Ibad hospital Samundri. Probability Random Sampling is used.


Eligibility criteria: Inclusion Criteria:

* Infarcted CVA patients
* Patients with hand improvement needed
* Patients in recovery stage of stroke from 2 months to 1 year
* Patients who can participate in 45 mins of session

Exclusion Criteria:

* Patients with hand function disturbed due to any other reason except infarcted CVA, - - - Patients with shoulder subluxation and upper limb contractures

Primary outcomes:
measure: The Fugl-Meyer Assessment (FMA)
timeFrame: 12 Months
measure: The Chedoke Arm and Hand Activity Inventory (CAHAI)
timeFrame: 12 months
Secondary outcomes:
Other outcomes:
Locations:
city: Lahore
country: Pakistan
facility: Minhaj Physiotherapy, opp Shalimar Hospital , Shalimar
state: Punjab
Study officials:
References:
Clinical trial NCT00325715: AGN 201904 Versus Esomeprazole in the Prevention of Aspirin-induced Stomach or Upper Intestinal Damage in Healthy Volunteers
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE1
Conditions: Peptic Ulcer
Lead sponsor: Allergan
Sponsor class: INDUSTRY
First posted: 2006-05-15
Enrollment: 150
Sex: ALL
Minimum age (years): 18
Maximum age (years): 65
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: PREVENTION

Brief summary: AGN 201904, a proton pump inhibitor, versus esomeprazole in the prevention of stomach or upper intestinal damage following administration of high-dose aspirin in healthy volunteers


Eligibility criteria: Inclusion Criteria:

* Healthy Adult Volunteers who have provided written informed consent

Exclusion Criteria:

* Volunteers with a history of upper gastrointestinal disease or who have a current diagnosis of upper gastrointestinal disease.
* Female volunteers who pregnant, nursing, or planning a pregnancy
* Volunteers with a history of drug or alcohol abuse

Primary outcomes:
measure: Stomach or upper intestinal erosions
Secondary outcomes:
Other outcomes:
Locations:
city: Houston
country: United States
state: Texas
Study officials:
References:
Clinical trial NCT05174715: Malnutrition Using GLIM Criteria and Comparing CT and BIA for Muscle Mass Measurement
Official title: Evaluation of Malnutrition in Patients Undergoing Major Abdominal Surgery Using GLIM Criteria and Comparing CT and BIA for Muscle Mass Measurement
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Malnutrition
Keywords: malnutrition, sarcopenia, GLIM criteria
Lead sponsor: Klinikum St. Georg gGmbH
Sponsor class: OTHER
First posted: 2022-01-03
Enrollment: 260
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Observational model: COHORT
Time perspective: RETROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Patients undergoing major abdominal surgery for gastrointestinal cancer

Brief summary: Evaluation of malnutrition with the help of the GLIM criteria. Muscle mass measurement, as recommended in the GLIM criteria was done with the help of abdominal CT scan and BIA. Both methods were compared and their association to the clinical outcome was assessed.

Detailed description: We retrospectively analysed 260 patients undergoing major abdominal surgery between January 2017 and December 2019. Patients were prospectively screened and assessed for malnutrition with Nutritional Risk Score (NRS) and Subjective Global assessment (SGA). Body composition was analysed with CT scan and BIA within 30 days before surgery. GLIM criteria were retrospectively determined referring to the Fat free Mass from BIA (FFMBIA) and Muscle Mass from axial CT scan at lumbar level 3 (MMCT). The prevalence of GLIM - malnutrition according to BIA and CT was evaluated. Multivariate logistic regression analysis was used to determine association between malnutrition and outcome parameters. ROC-curves specified sensitivity and specificity of the different tools and areas under the curve were calculated.

Eligibility criteria: Inclusion Criteria:

* age above 18 years
* BIA and CT scan was available within 31 days before surgery
* patients undergoing major abdominal surgery for gastrointestinal cancer

Exclusion Criteria:

* patients who were not able to agree to the participation
* missing assessment of the nutritional status
* leck of quality of the CT scan

Primary outcomes:
measure: overall complications
timeFrame: 31 days POD
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
References:
Clinical trial NCT05399615: Detection of Bacterial and Viral Pathogens Infection Among Hospitalized Patients Feasibility Study
Official title: Detection of Bacterial and Viral Pathogens Infection Among Hospitalized Patients Feasibility Study
Study type: INTERVENTIONAL
Overall status: WITHDRAWN
Phase: NA
Conditions: Infectious Disease
Lead sponsor: Scentech Medical Technologies Ltd
Sponsor class: INDUSTRY
First posted: 2022-06-01
Enrollment: 0
Sex: ALL
Minimum age (years): 18
Maximum age (years): 80
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: NON_RANDOMIZED
Intervention model: PARALLEL
Intervention model description: parallel assignment
Primary purpose: DIAGNOSTIC

Brief summary: Detection of bacterial and viral pathogens infection among hospitalized patients using breath analysis - feasibility study.

Detailed description: A diagnostic prospective single-site study, with no anticipated risks or constraints.

Primary objective: To identify a set of breath Volatile Organic Compound biomarkers that enable the detection of pathogens infection and inflammatory response to pathogens infection among hospitalized patients.

Eligibility criteria: Inclusion Criteria:

* Age 18 to 80 years at the time of consent
* Capable of understanding written and/or spoken language
* Able to provide informed consent
* Negative results for SARS-CoV-2
* Diagnosed with suspected respiratory infection

Exclusion Criteria:

* Under guardianship or deprived of liberty
* Pregnant or lactating woman
* Not able to breathe through mask for 8 minutes
* Intubated patients
* Patients in critical condition
* Diagnosed with hospital-acquired infection
* Medical history of malignancies

Primary outcomes:
measure: Discovery of exhaled breath biomarkers
timeFrame: Through the study completion, up to 3 months.
Secondary outcomes:
measure: The association of exhaled biomarkers with inflammatory known biomarkers.
timeFrame: Through the study completion, up to 3 months.
Other outcomes:
Locations:
city: Poriyya
country: Israel
facility: Poriya Medical Center
Study officials:
affiliation: Poriya Medical Center
name: Avi Peretz, PhD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT04823715: Transarterial Chemoembolization Plus Hypofractionnated Radiotherapy vs. Surgery in Locally Advanced Hepatocellular Carcinoma: an IPTW Comparison
Official title: Transarterial Chemoembolization Plus Hypofractionnated Radiotherapy vs. Surgery in Locally Advanced Hepatocellular Carcinoma: an IPTW Comparison
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Non-metastatic Hepatocellular Carcinoma
Keywords: Liver neoplasms
Carcinoma
Hepatocellular
Radiation therapy
TACE
Transarterial Chemoembolization
Lead sponsor: Hospices Civils de Lyon
Sponsor class: OTHER
First posted: 2021-04-01
Enrollment: 163
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: RETROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Patients aged 18 or older, presenting Child-Pugh class A HCC treated in Hospices Civils de Lyon between 2004 and 2016

Brief summary: Patients with non-metastatic unresectable hepatocellular carcinoma


Eligibility criteria: Inclusion Criteria:

* Age ≥18 years of age
* ECOG 0-2
* Histologically proven hepatocellular carcinoma or proven according to radiological and biochemical criteria (EASL-AASLD) in cirrhotic patients
* Child-Pugh class A
* Absence of truncular or lobar portal vein invasion, or suprahepatic vein invasion

Exclusion Criteria:

* Uncontrolled replication of hepatitis B virus
* Transplanted liver
* Previous abdominal irradiation
* Previous treatment of HCC with systemic therapy, or with surgical resection in the 2 previous years
* Metastatic illness

Primary outcomes:
measure: Disease-free survival of the patient after start of treatment
timeFrame: Within 10 years after the treatment (surgical resection or TACE)
Secondary outcomes:
Other outcomes:
Locations:
city: Lyon
country: France
facility: Croix-Rousse Hospital, Hospices Civils de Lyon
Study officials:
References:
Clinical trial NCT02223715: Prospective Observational Study of Clostridium Difficile Infection in Asian Pacific Countries
Official title: A Prospective Study to Characterize the Management and Outcome of Clostridium Difficile Infection （CDI) in Asian Pacific Countries
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Clostridium Difficile Infection
Lead sponsor: Otsuka Pharmaceutical Co., Ltd.
Sponsor class: INDUSTRY
First posted: 2014-08-22
Enrollment: 600
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: CASE_ONLY
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: Patients with a confirmed diagnosis of CDI(C. difficile infection) who willing to provide informed consent and/or informed assent or data release, according to local regulation.

Brief summary: The aim of this study is to conduct an Asia-Pacific, multi-center, prospective observational study to characterize patients with CDI as well as to understand treatment and management of the disease.


Eligibility criteria: Inclusion Criteria:

* Patients with a confirmed diagnosis of CDI, as documented by diarrheal symptoms and positive stool test result for CDT or toxigenic C. difficile, or colonoscopic findings of PMC
* Patients and/or legal guardian willing to provide informed consent and/or informed assent or data release, according to local regulations

Exclusion Criteria:

* Patients with diarrheal symptoms caused by bacteria other than C. difficile, such as Salmonella, Campylobacter, Vibrio, Shigella, and Escherichia coli.

Primary outcomes:
measure: Patient Demographics
timeFrame: At the study at the time of CDI diagnosis enrollment
measure: Status at the End of CDI Episode
timeFrame: From the time of CDI diagnosis to the end of the treatment
Secondary outcomes:
measure: Clinical Complication
timeFrame: From the time of CDI diagnosis to recovery or recurrence
measure: Recurrence or Not After 2 Months Follow-up
timeFrame: From the time of CDI diagnosis to 2 months follow-up
Other outcomes:
Locations:
city: Kanto Region
country: Japan
Study officials:
References:
Clinical trial NCT02815215: Efficacy Analysis of Minimally Invasive Carroll's Technique in Treatment of Congenital Idiopathic Clubfoot
Official title: A Retrospective Multicenter Analysis on Treatment of Congenital Idiopathic Clubfoot With Minimally Invasive Carroll's Technique
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: EARLY_PHASE1
Conditions: Congenital Clubfoot
Keywords: congenital clubfoot
Lead sponsor: Children's Hospital of Chongqing Medical University
Sponsor class: OTHER
Collaborators: name: Hunan Children's Hospital
name: Shenzhen Children's Hospital
name: Guangzhou Women and Children's Medical Center
First posted: 2016-06-28
Enrollment: 80
Sex: ALL
Minimum age (years): 28
Maximum age (years): 4
Standard ages: CHILD
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: Congenital clubfoot(CCF) is a kind of common congenital foot deformities in children. Though Ponseti method can cure most of the CCF patients, there are still part of patients can not get satisfactory recovery, especially those children classified as Dimeglio grade Ⅲ and Ⅳ. Carroll's technique is considered to be an ideal method of surgical treatment. But the postoperative scar is relatively large, and accordingly the postoperative complications is still common. Based on the clinical practice of the investigator's group, a modification of Carroll's technique, minimally invasive Carroll's technique, was applied. For the Dimeglio grade Ⅲ and Ⅳ CCF, the postoperative excellent and good rate was over 90%. Therefore, the investigator conducted a multicenter randomized controlled trial on treatment of congenital idiopathic clubfoot with minimally invasive Carroll's technique.


Eligibility criteria: Inclusion Criteria:

* First diagnosed congenital idiopathic clubfoot cases classified as Dimeglio grade Ⅲ and Ⅳ

Exclusion Criteria:

* Age≤28 days, and Age\>4 years.
* Accompanied by serious diseases of other organs.
* Children with inherited metabolic disease and connective tissue disease.
* Clubfoot caused by trauma, cerebral palsy, congenital multiple joint contracture, polio, spina bifida occulta, and clubfoot derived from spinal cord disease.

Primary outcomes:
measure: Dimeglio classification system
timeFrame: 0 month(before treatment); 3rd month, 1st year, 3rd year(after treatment)
Secondary outcomes:
measure: Pirani scoring system
timeFrame: 0 month(before treatment); 3rd month, 1st year, 3rd year(after treatment)
Other outcomes:
measure: talocalcaneal angle measurement
timeFrame: 0 month(before treatment); 3rd month, 1st year, 3rd year(after treatment)
Locations:
city: Chongqing
country: China
facility: Children's Hospital of Chongqing Medical University
state: Chongqing
Study officials:
affiliation: Children's Hospital of Chongqing Medical University
name: Ming Li, master
role: PRINCIPAL_INVESTIGATOR
References:
citation: Carroll NC. Clubfoot in the twentieth century: where we were and where we may be going in the twenty-first century. J Pediatr Orthop B. 2012 Jan;21(1):1-6. doi: 10.1097/BPB.0b013e32834a99f2.
Clinical trial NCT06261515: Multi-omics Analysis of Oral-gut Microbial Profiles
Official title: Multi-omics Multi-specimens Evaluation of Oral-gut-systemic Profiles in Patients With Stage III-IV Periodontitis Pre- and After-therapy
Study type: INTERVENTIONAL
Overall status: RECRUITING
Phase: NA
Conditions: Periodontitis
Lead sponsor: University of Turin, Italy
Sponsor class: OTHER
First posted: 2024-02-15
Enrollment: 70
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: TREATMENT

Brief summary: Periodontitis is a chronic inflammatory disease of the tooth supporting structures induced by a dysbiosis in the oral and subgingival microenvironment of susceptible patients. The long-term swallowing of high doses of periodontal pathogenic microorganisms could induce a dysbiosis of the intestinal microbiota, favouring the establishment of an 'inflamed' microbiome in terms of composition and/or function. The present project is aimed at a better understanding of the etiopathogenetic correlation between periodontitis and intestinal dysbiosis, and aims to explore the hypothesis that periodontal treatment may influence the multi-omics profile on the oral-gut-systemic axis. 70 patients affected by stage III-IV periodontitis will be recruited, and treated by means of full-mouth scaling and root planing. Salivary, subgingival plaque, plasma and stool samples, together with a complete periodontal charting and a food diary will be collected and compared at baseline and after treatment. Age, gender and BMI-matched healthy individuals will be recruited as controls.


Eligibility criteria: Inclusion Criteria:

* periodontitis Stage III or IV
* BMI between 20 and 29 kg/m2
* free diet
* presence of at least 20 teeth

Exclusion Criteria:

* systemic diseases (including diabetes, thyroid, liver, or kidney diseases)
* dietary allergies
* use of antibiotics or probiotics during the previous 90 days
* pregnancy or breast feeding

Primary outcomes:
measure: Changes in gut microbial profile measured in stool samples
timeFrame: Baseline and 90 days
measure: Changes in oral microbial profile measured in saliva samples
timeFrame: Baseline and 90 days
measure: Changes in oral microbial profile measured in subgingival plaque samples
timeFrame: Baseline and 90 days
Secondary outcomes:
measure: Changes in oral-gut metabolome measured in stool samples
timeFrame: Baseline and 90 days
measure: Changes in oral-gut miRNAome measured in stool samples
timeFrame: Baseline and 90 days
measure: Metabolic plasma changes
timeFrame: Baseline and 90 days
Other outcomes:
Locations:
city: Turin
country: Italy
facility: CIR Dental School
Study officials:
References:
Clinical trial NCT02672215: RCT Computer-tailored Intervention on Workplace Sitting
Official title: The Effectiveness of a Web-based Computer-tailored Intervention on Workplace Sitting: a Randomized Controlled Trial
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Sedentary Lifestyle
Lead sponsor: University Ghent
Sponsor class: OTHER
First posted: 2016-02-03
Enrollment: 1061
Sex: ALL
Minimum age (years): 18
Maximum age (years): 70
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: FACTORIAL
Primary purpose: PREVENTION

Brief summary: A theory-driven, web-based, computer-tailored advice to influence sitting at work was developed. The study investigated the effects of this computer-tailored intervention to influence workplace sitting on behavioural measures.

Detailed description: The study investigated the effects of the theory-driven, web-based, computer-tailored intervention to influence workplace sitting on objectively measured sitting time, standing time and breaks from sitting, as well as self-reported context-specific sitting. The computer-tailored advice was compared to a generic advice and a 'no-advice' control at 1-month and 3-months follow-up. The 'tailored' group received a web-based computer-tailored intervention including personalized feedback and tips on how to reduce and/or interrupt workplace sitting. The 'generic' group received a web-based intervention containing generic information and tips to reduce and/or interrupt workplace sitting. The control group was a waitlist control condition and received the generic intervention after completing all measurements. Participants were recruited from a convenience sample of two companies (university and environmental agency) in Flanders (i.e. northern Dutch-speaking part of Belgium), mainly employing desk-based workers, having more than 100 staff members and each having at least three different worksite locations.

Eligibility criteria: Inclusion Criteria:

* being employed

Exclusion Criteria:

* not being able to stand

Primary outcomes:
measure: sitting time
timeFrame: one week
measure: self-reported context-specific sitting time
timeFrame: one week
measure: standing time
timeFrame: one week
measure: breaks from sitting
timeFrame: one week
Secondary outcomes:
measure: psychosocial correlates of sitting
timeFrame: one week
Other outcomes:
Locations:
Study officials:
References:
citation: De Cocker K, De Bourdeaudhuij I, Cardon G, Vandelanotte C. What are the working mechanisms of a web-based workplace sitting intervention targeting psychosocial factors and action planning? BMC Public Health. 2017 May 3;17(1):382. doi: 10.1186/s12889-017-4325-5.
citation: De Cocker K, De Bourdeaudhuij I, Cardon G, Vandelanotte C. The Effectiveness of a Web-Based Computer-Tailored Intervention on Workplace Sitting: A Randomized Controlled Trial. J Med Internet Res. 2016 May 31;18(5):e96. doi: 10.2196/jmir.5266.
Clinical trial NCT02013115: Curosurf/Budesonide for Infants With Respiratory Distress Syndrome
Official title: Curosurf/Budesonide for Infants With Respiratory Distress Syndrome
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Respiratory Distress Syndrome
Keywords: infant
respiratory distress syndrome
Lead sponsor: Daping Hospital and the Research Institute of Surgery of the Third Military Medical University
Sponsor class: OTHER
First posted: 2013-12-17
Enrollment: 300
Sex: ALL
Maximum age (years): 12
Standard ages: CHILD
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: SINGLE_GROUP
Primary purpose: TREATMENT

Brief summary: Infants showing high local pulmonary inflammation diagnosted by respiratory distress syndrome usually need the second or more pulmonary surfactant and is easier to developing to Brochopulmonary. Cursurf is used worldwide in infants with respiratory distress syndrome, Budesonide is a glucocorticoid with a high local anti-inflammatory effect.Our hypothesis is Cursurf combined with Budesonide could reduced the need of Cursurf and incidence of Brochopulmonary dysplasia.


Eligibility criteria: Inclusion Criteria:

* Clinical diagnosis of respiratory distress syndrome

Exclusion Criteria:

* pneumothorax
* surgical disease
* major congenical defects

Primary outcomes:
measure: need of pulmonary surfactant
timeFrame: one month
Secondary outcomes:
measure: the incidence of bronchopulmonary dysplasia
timeFrame: gestional age 36 weeks or later
Other outcomes:
measure: need of intubation
timeFrame: one month
Locations:
city: Chongqing
country: China
facility: Department of Pediatrics, Daping Hospital, Research Institute of Surgery, Third Military Medical University
state: Chongqing
Study officials:
References: