Clinical trial NCT05127928: Antioxidants Vitamins and Muscle Damage
Official title: Antioxidants Vitamins and Muscle Damage
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Oxidative Stress
Keywords: antioxidant vitamins
oxidative damage
Lead sponsor: Universidad Europea de Madrid
Sponsor class: OTHER
First posted: 2021-11-19
Enrollment: 18
Sex: ALL
Minimum age (years): 18
Maximum age (years): 33
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: Determine if acute supplementation with antioxidant vitamins (vitamin C and vitamin E) influences the muscle damage and fatigue caused after an acute session of eccentric training.

Detailed description: A randomized, single-blind, placebo-control parallel trial will be conducted. In a previous session volunteers will be interviewed to determine if they meet the inclusion criteria.

Participants should avoid ingesting of foods that contain high amounts of antioxidant compounds: more than two juices of fruits, more than four cups of coffee or tea. Juices with high antioxidant content should be avoided. Alcoholic beverages should also be avoided. Participants will be divided in to groups and will performance one resistance exercise sessions. Prior to exercise, one group will intake supplementation VitC (1000 mg) + VitE (235 mg) and the other supplementation with placebo.

The following sequence will be performed in each session: 1) baseline assessment (analysis of the composition body, blood draw and parameters of performance) prior to exercise session ; 2) administration of vitamin or placebo supplementation 2 hours before exercise session ; 3) post-exercise assessments (blood biomarkers and performance parameters) immediately after the session and after 24 hours. DOMS will also be assessed 48 h and 72 h after training. The training session implemented will be designed by a Sport Scientific

Eligibility criteria: Inclusion Criteria:

* Healthy
* Physically active

Exclusion Criteria:

* Injuries
* Supplementation or drugs
* Smokers

Primary outcomes:
measure: Percentage of body fat and muscle mass
timeFrame: Prior to the intervention
measure: DOMS
timeFrame: 0 hours post exercise
measure: DOMS
timeFrame: 24 hours post exercise
measure: Blood malondialdehyde (MDA)
timeFrame: 2 hours prior to exercise
measure: Blood creatine quinase (CK)
timeFrame: 2 hours prior to exercise
measure: Blood malondialdehyde (MDA)
timeFrame: Inmediatly after exercise
measure: Blood malondialdehyde (MDA)
timeFrame: 24 hours after exercise
measure: Blood creatine quinase (CK)
timeFrame: 24 hours after exercise
measure: Jump height in a Counter Movement Jump
timeFrame: 2 hours prior to exercise
measure: Jump height in a Counter Movement Jump
timeFrame: Inmediatly after exercise
measure: Jump height in a Counter Movement Jump
timeFrame: 24 h after exercise
measure: Jump Height in a Squat Jump
timeFrame: 24 h after exercise
measure: Jump Height in a Squat Jump
timeFrame: Inmediately after exercise
measure: Jump Height in a squat Jump
timeFrame: 2 hours prior to exercise
measure: Jump Height in a Drop Jump
timeFrame: 2 hours prior to exercise
measure: Jump Height in a Drop Jump
timeFrame: Inmediately after exercise
measure: Contact time in a Drop Jump
timeFrame: Inmediately after exercise
measure: Jump Height in a Drop Jump
timeFrame: Inmediately after exercise
measure: Contact time in a Drop Jump
timeFrame: 24 hours after exercise
measure: Jump Height in a Drop Jump
timeFrame: 24 hours after exercise
measure: Contact time in a Drop Jump
timeFrame: Inmediately after exercise
measure: Concentration of blood lactate
timeFrame: 2 hours before exercise
Secondary outcomes:
Other outcomes:
Locations:
city: Madrid
country: Spain
facility: Universidad Europea de Madrid
Study officials:
References: