louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT01818089: Monitoring of Lung Sounds of Patients With Pneumonia
Official title: Monitoring of Lung Sounds of Patients With Pneumonia
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Pneumonia
Lead sponsor: RWTH Aachen University
Sponsor class: OTHER
First posted: 2013-03-26
Enrollment: 17
Sex: ALL
Minimum age (years): 18
Maximum age (years): 90
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: patients with ambulant aquired pneumonia

Brief summary: The aim of this study is to investigate if any correlation between lung sounds of pneumonia patients and the clinical development or therapy of the pneumonia exists.


Eligibility criteria: Inclusion Criteria:

* ambulant aquired pneumonia with typically radiological signs
* hospitalisation at medical clinic I, university hospital Aachen
* age at least \> 18 years
* CRB-65 score \> 1
* CRP\> 60mg/l
* fever
* lung sounds audible by stethoscope
* legal capacity and being able to understand and to follow the instructions of the study staff
* being able to consent and being able to understand the importance and the consequence of the study
* not being accomondated in an institution

Exclusion Criteria:

* pneumonia acquired in a hospital
* artificial respiration or other means for supporting respiration
* allergic reaction because of skin contact with polymers
* pregnancy or breast feeding

Primary outcomes:
measure: Sound of lungs
timeFrame: 5 days
Secondary outcomes:
Other outcomes:
Locations:
city: Aachen
country: Germany
facility: Univeristy Hospital Aachen
state: North Rhine Westfalia
Study officials:
affiliation: RWTH Aachen University Hospital
name: Christian Cornelissen, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT06466889: Mastocytosis Registry (of Zurich)
Official title: Genetic, Multiomic and Cytokine-based Mapping of Patients With Mastocytosis/Hypertryptasemia at the University Hospital of Zurich German: Mastozytose-Register: Datenerfassung Und Weiterverwendung Von Biologischem Material Von Patienten Mit Mastozytose, Welche am Universitätsspital Zürich Behandelt Werden
Study type: OBSERVATIONAL
Overall status: RECRUITING
Conditions: Mastocytosis
Hypertryptasemia
Keywords: mast cell disease
Lead sponsor: University of Zurich
Sponsor class: OTHER
First posted: 2024-06-20
Enrollment: 400
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: all patients with mastocytosis or hypertryptasemia

Brief summary: The study aims to summarize patients with mastocytosis and hypertryptasämia (without underlying mastocytosis or no bone marrow biopsy) in relation to demographic information, clinical progress and treatment courses. Biologic samples are collected from available routine diagnostics (serum, skin tissue, gut mucosa, bone marrow, and others) for further use in experimental research.


Eligibility criteria: Inclusion Criteria:

* Adult patients with mastocytsis/hypertryptasemia which are treated at the university hospital of Zurich
* available informed consent

Exclusion Criteria:

* denied consent

Primary outcomes:
measure: Demographics
timeFrame: 2010-2025
measure: Disease progression
timeFrame: 2010-2025
Secondary outcomes:
Other outcomes:
Locations:
city: Zurich
country: Switzerland
facility: University Hospital of Zurich
Study officials:
References:
Clinical trial NCT02144389: Arachidonic Acid Treatment Against Schistosomiasis Infection in Children
Official title: Effects of Arachidonic Acid Supplementation on Schistosomiasis Mansoni Infection in Egyptian School Children
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Schistosomiasis
Bilharzia
Keywords: Arachidonic acid
Bilharzia
Mansoni
Schistosomiasis
Polyunsaturated fatty acid
Lead sponsor: DSM Nutritional Products, Inc.
Sponsor class: INDUSTRY
Collaborators: name: National Liver Institute, Egypt
name: Cairo University
name: High Institute of Public Health, Egypt
First posted: 2014-05-22
Enrollment: 335
Sex: ALL
Minimum age (years): 6
Maximum age (years): 15
Standard ages: CHILD
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: Randomized Controlled Trial:

The investigational materials used in this trial were administered to subjects each day by trained clinicians.

Primary Objectives:

* assess the effect of dietary supplementation with arachidonic acid on the cure rates for Schistosomiasis mansoni with and without concomitant treatment with praziquantel.
* assess the safety of dietary supplementation using arachidonic acid in children with clinically confirmed schistosomiasis mansoni infection.

Secondary objective:

* to measure changes in total phospholipids in plasma.


Eligibility criteria: Inclusion Criteria:

* consent from parent or legal guardian
* clinically confirmed schistosomiasis

Exclusion Criteria:

* not infected with schistosomiasis
* less than 6 or greater than 15 years of age

Primary outcomes:
measure: Percent egg reduction
timeFrame: 4 weeks after end of 1 day PZQ treatment
Secondary outcomes:
measure: Biochemical and hematological parameters
timeFrame: Three days after a 15-day ARA supplementation
measure: Total plasma phospholipids
timeFrame: Three days after 15-day ARA supplementation.
Other outcomes:
Locations:
city: Shebin El-Kom
country: Egypt
facility: National Liver Institute, Menoufiya University,
state: Menoufiya
city: Alexandria
country: Egypt
facility: Tropical Health Department, High Institute of Public Health, Alexandria University
city: Cairo
country: Egypt
facility: Cairo University
Study officials:
affiliation: Cairo University
name: Rashika El Ridi
role: PRINCIPAL_INVESTIGATOR
affiliation: National Liver Institute, Menoufiya University
name: Sahar Selim, Ph.D.
role: STUDY_DIRECTOR
affiliation: High Institute of Public Health, Alexandria University
name: Rashida Barakat, Ph.D.
role: STUDY_DIRECTOR
References:
citation: Barakat R, Abou El-Ela NE, Sharaf S, El Sagheer O, Selim S, Tallima H, Bruins MJ, Hadley KB, El Ridi R. Efficacy and safety of arachidonic acid for treatment of school-age children in Schistosoma mansoni high-endemicity regions. Am J Trop Med Hyg. 2015 Apr;92(4):797-804. doi: 10.4269/ajtmh.14-0675. Epub 2015 Jan 26.
Clinical trial NCT04024189: Patient Experience of Consent for Cancer Surgery in Light of Recent Changes to UK Law- a Questionnaire Study
Official title: Audit of Informed Consent of Patients Undergoing Surgery
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Patient Satisfaction
Lead sponsor: The Christie NHS Foundation Trust
Sponsor class: OTHER
First posted: 2019-07-18
Enrollment: 39
Sex: ALL
Minimum age (years): 18
Maximum age (years): 80
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: RETROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: All patients undergoing surgery during a 6 week period at The Christie NHS Foundation Trust

Brief summary: Since the 2015 Montgomery vs Lanarkshire Health Board ruling, the consent process in the UK has had to change. In practice, this means that doctors must ask themselves whether the patient knows about the material risks of the treatment being proposed, alternatives to the treatment, and whether reasonable care has been taken to ensure the patient actually knows this. This study aims to determine patients' perspectives of consent for major cancer surgery in light of the Lanarkshire ruling.

Detailed description: A patient satisfaction survey was administered to patients who had undergone urological, gynaecological, colorectal, and plastic surgical procedures at a specialised cancer centre where changes to consent processes in light of the Lanarkshire ruling had been implemented.

Eligibility criteria: Inclusion Criteria:

* All patients who have been admitted and undergone surgery within a 6 week period between April - June 2018.

Exclusion Criteria:

* Any patient who could not complete the survey questionnaire i.e. English was not their first language or to unwell to complete.

Primary outcomes:
measure: Patients understanding of the risks associated with the procedure they will be having and the alternatives available to them was assessed using a study specific questionnaire.
timeFrame: 6 weeks
measure: Patients views and feelings regarding their experiences in relation to support from healthcare professionals was assessed using a study specific patient questionnaire.
timeFrame: 6 week
Secondary outcomes:
Other outcomes:
Locations:
city: Manchester
country: United Kingdom
facility: The Christie NHS Foundation Trust
Study officials:
affiliation: The Christie NHS Foundation Trust
name: Omer Aziz
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT06384989: Safety-Enhancing Motor Vehicle Child Safety Seat
Official title: Phase II - Safety-Enhancing Motor Vehicle Child Safety Seat
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Motor Vehicle Injury
Safety Issues
Keywords: child restraint system
Lead sponsor: Minnesota HealthSolutions
Sponsor class: INDUSTRY
First posted: 2024-04-25
Enrollment: 50
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: The study population will be recruited from the Central Ohio area. Adults who meet the above criteria will be enrolled. Efforts will be made to include both males and females, across a range of ages, as well as minorities, as these groups' experiences around child seats may vary.

Brief summary: This study aims to assess the usability of a load leg design for caregivers who must install the child safety seat into a vehicle. The specific aims are to quantify any errors committed by the participants while installing the car seat and to assess participants' opinions on the car seat's load leg design.

Detailed description: A descriptive study will be conducted to determine whether human subjects are able to install the new feature of the prototype car seat correctly. Participants will be presented with the prototype car seat and a set of basic written instructions and labels to guide their installations. The percentage of participants who use the new feature and use it correctly will be reported. Any installation errors on other parts of the child seat (seat belt, lower anchors, top tether) will also be reported.

Eligibility criteria: Inclusion Criteria:

* Age 18 or older
* Be a care provider to a child who is up to 4 years of age
* Have installed a child safety seat in the last 2 years
* Able to lift and install a child safety seat into a vehicle
* English-speaking (because consent forms and explanation will be given in English)

Exclusion Criteria:

* Not meeting any of the above

Primary outcomes:
measure: Overall Correct Use of Load Leg
timeFrame: 1 study visit, an average of 30 minutes
measure: Attempt to Use Load Leg Without Prompting
timeFrame: 1 study visit, an average of 30 minutes
measure: Correct Load Leg Length
timeFrame: 1 study visit, an average of 30 minutes
measure: Correct Load Leg Angle
timeFrame: 1 study visit, an average of 30 minutes
Secondary outcomes:
measure: Correct Understanding of Load Leg's Purpose
timeFrame: 1 study visit, an average of 30 minutes
measure: Participants Who Like Having the Load Leg
timeFrame: 1 study visit, an average of 30 minutes
Other outcomes:
Locations:
city: Columbus
country: United States
facility: The Ohio State University
state: Ohio
Study officials:
affiliation: Ohio State University
name: Julie Mansfield, PhD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT03428789: Nerve Coaptation in DIEP Flap Breast Reconstruction
Official title: Sensory Recovery of the Breast Following Innervated and Non-innervated DIEP Flap Breast Reconstructions
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Breast Cancer
Keywords: breast reconstruction
DIEP flap
Nerve coaptation
Sensory recovery
Lead sponsor: Maastricht University Medical Center
Sponsor class: OTHER
First posted: 2018-02-12
Enrollment: 81
Sex: FEMALE
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: In this prospective study, patients who underwent an innervated or non-innervated DIEP flap breast reconstruction between January 2010 and July 2016 at Maastricht University Medical Center in the Netherlands were included if they returned for follow-up between September 2015 and July 2017.

Brief summary: The sensory recovery of the breast remains an undervalued aspect of breast reconstruction and surgical reinnervation is not regarded as a priority by most reconstructive surgeons. A prospective study was conducted of all patients who underwent either innervated or non-innervated DIEP flap breast reconstruction in Maastricht University Medical Center and returned for follow-up between September 2015 and July 2017. Semmes-Weinstein monofilaments were used for sensory testing of the breast. This study showed that nerve coaptation in DIEP flap breast reconstruction resulted in a significantly improved sensation of the reconstructed breast compared to non-innervated flaps.


Eligibility criteria: Inclusion Criteria:

* Female patients 18 years or older
* Unilateral or bilateral DIEP flap breast reconstruction
* Returned for follow-up between September 2015 and July 2017
* Informed consent

Exclusion Criteria:

* Bilateral breast reconstruction with a unilateral innervated DIEP flap and a contralateral non-innervated flap
* Flaps that required a take-back

Primary outcomes:
measure: The extent of sensory recovery of the reconstructed breast to touch
timeFrame: Through study completion up to 24 months postoperatively
Secondary outcomes:
Other outcomes:
Locations:
city: Maastricht
country: Netherlands
facility: Maastricht University Medical Center
state: Limburg
Study officials:
affiliation: Maastricht University Medical Center
name: René van der Hulst, MD, PhD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT06946589: Cardiac Changes After Effective Dose Carbetocin for Elective Caesarian Section
Official title: Cardiac Changes After Effective Dose Carbetocin for Elective Caesarian Section
Study type: INTERVENTIONAL
Overall status: NOT_YET_RECRUITING
Phase: PHASE4
Conditions: Cardiac Ischemia
Cesarian Section
Keywords: carbetocin
duratocin
cardiac symptoms
Lead sponsor: Queen's University
Sponsor class: OTHER
First posted: 2025-04-27
Enrollment: 200
Sex: FEMALE
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The goal of this project is to examine the cardiac symptoms and physiologic changes after administration of a reduced dose of carbetocin in participants undergoing elective cesarian section.

* Does reduced dose carbetocin (50mcg) have fewer cardiac side effects than usual dose carbetocin (100mcg) when comparing patient reported symptoms, ECG changes and troponin increases?
* Is there a relationship between patient reported cardiac symptoms after carbetocin administration and subjective measures of cardiac ischemia (ECG changes and troponin increases? Researchers will compare 50mcg of carbetocin to the control group of 100mcg of carbetocin in patients undergoing elective cesarian section.

Participants will:

* Be given 50mcg or 100mcg of carbetocin during cesarian section
* Asked to report cardiac symptoms
* Be assessed for ECG changes and blood loss using standard of practice monitoring
* Have a troponin I blood test completed after delivery


Eligibility criteria: Inclusion Criteria:

* Undergoing elective cesarian section
* Primary and repeat cesarian section

Exclusion Criteria:

* Prior and current cardiovascular co-morbidities including pre-eclampsia
* BMI greater than 50
* Pre-existing bleeding disorders
* Allergy to carbetocin
* Age under 18

Primary outcomes:
measure: Patient reported symptoms
timeFrame: within 5 minutes of study drug administration
Secondary outcomes:
measure: Troponin I levels
timeFrame: One day after study drug administration
measure: ECG: ST segment
timeFrame: 5 minutes after study drug administration
Other outcomes:
measure: Estimated blood loss during surgery
timeFrame: Within 1 hour of study drug administration
measure: Surgeons assessment of uterine tone
timeFrame: 3 minutes after study drug administration
measure: Hemoglobin change
timeFrame: Preoperatively and one day postoperatively
Locations:
city: Kingston
country: Canada
facility: Kingston Health Sciences Centre
state: Ontario
Study officials:
affiliation: Queen's University
name: Jordan Leitch, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT02852889: Internal Jugular Vein Distensibility to Predict Fluid Responsiveness in Patients After Cardiac Surgery
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Cardiac Surgery
Keywords: internal jugular vein distensibility,haemodynamics
Lead sponsor: Shanghai Zhongshan Hospital
Sponsor class: OTHER
First posted: 2016-08-02
Enrollment: 50
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: CASE_CONTROL
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: Patients after cardiac surgery

Brief summary: The purpose of the study was to verify the efficacy of using internal jugular vein (IJV) size and distensibility as an index of fluid responsiveness in mechanically ventilated patients after cardiac surgery.


Eligibility criteria: Inclusion Criteria:

* hypotension
* oliguria
* high lactate level

Exclusion Criteria:

* cardiac arrhythmia
* clinically relevant tricuspid or mitral regurgitation, clinically relevant right heart failure
* thrombosis in any large upper body veins
* bilaterally inserted venous catheters

Primary outcomes:
measure: fluid responsiveness （mean artery pressure、cardiac output、stroke volume variation、internal jugular vein distensibility）
timeFrame: after fluid challenge (30min)
Secondary outcomes:
Other outcomes:
Locations:
city: Shanghai
country: China
facility: Zhongshan Hospital, Fudan University
state: Shanghai
Study officials:
affiliation: Fudan University
name: Guo-wei Tu, PhD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT06280989: Effect of Kinesio Taping Versus Myofascial Release on Menstrual Low Back Pain
Official title: Effect of Kinesio Taping Versus Myofascial Release on Menstrual Low Back Pain in Young Females
Study type: INTERVENTIONAL
Overall status: NOT_YET_RECRUITING
Phase: NA
Conditions: Low Back Pain
Keywords: kinesio taping
myofascial release technique
Lead sponsor: Cairo University
Sponsor class: OTHER
First posted: 2024-02-28
Enrollment: 44
Sex: FEMALE
Minimum age (years): 18
Maximum age (years): 25
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Intervention model description: kinesio taping and myofascial release technique
Primary purpose: TREATMENT

Brief summary: the aim of this study is to investigate the efficacy of kinesio taping versus myofascial release technique on menstrual low back pain in young females

Detailed description: : Menstrual low back pain is a prevalent condition among women. Menstrual low back pain occurrence is affected by hormonal changes. Menstrual low back pain incidence more than 40% to 50% during the menstrual phase (days 1-6) of the menstrual cycle, while the range of prevalence was 45 to 95%. It has a high prevalence among females, especially females aged 20 to 25 years old. Hormonal changes might play an important role in the formation of Menstrual low back pain and is the main cause of feeling of pain during menstrual cycle. kinesio taping and myofascial release technique play an important role in the treatment of Menstrual low back pain. this trial has two groups; one will receive kinesio taping three days and the second will receive myofascial release technique for12 sessions through 3 consecutive menstrual cycle

Eligibility criteria: Inclusion Criteria:

1. Healthy young virgin females suffering from menstrual low back pain diagnosed by the gynecologist.
2. Their ages will be ranged from 18-25 years\&#39; old
3. Their body mass index will be ranged from 20-25 kg/m2.
4. All females have regular menstruation
5. Their pain intensity is scored as \&gt; 4 on VAS just before or during the first 3 days of the menstruation

   -

Exclusion Criteria:

Females will be excluded from the study if they have:

1. Any orthopedic problems such as trauma at lower spine, congenital malformation at spine and scoliosis.
2. Any gynecological problem such as irregular menstrual cycle, secondary dysmenorrhea due to endometriosis, ovarian cyst, uterine fibroid and congenital malformation or pelvic inflammation.
3. Athletic females
4. Allergy to kinesio taping.

   -

Primary outcomes:
measure: pain intensity
timeFrame: up to four weeks]
measure: pain pressure threshold
timeFrame: up to four weeks]
Secondary outcomes:
measure: severity of dysmenorrhea
timeFrame: up to four weeks]
measure: Assess the function disability level
timeFrame: up to four weeks]
Other outcomes:
Locations:
city: Giza
country: Egypt
facility: Hala mohamed ahmed morsy
Study officials:
affiliation: Cairo University
name: Manal El El shafei, lecture
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT03869489: Decision Making in Video Games
Official title: Decision Making in Video Games
Study type: INTERVENTIONAL
Overall status: WITHDRAWN
Phase: NA
Conditions: Cognitive Change
Keywords: approach motivation
avoidance motivation
transcranial direct current stimulation
Lead sponsor: Tufts University
Sponsor class: OTHER
First posted: 2019-03-11
Enrollment: 0
Sex: ALL
Minimum age (years): 18
Maximum age (years): 35
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: NON_RANDOMIZED
Intervention model: SINGLE_GROUP
Primary purpose: BASIC_SCIENCE

Brief summary: The purpose of this study is to determine whether anodal transcranial direct current stimulation (tDCS) applied to the left dorsolateral prefrontal cortex induces approach motivation, and whether anodal tDCS applied to the right dorsolateral prefrontal cortex induces avoidance motivation. This study consists of three experiments: one in which an approach/avoidance video game is validated, one in which the effect of anger and fear on approach/avoidance is studied, and one in which the effect of tDCS is studied. Only the experiment in which the effect of tDCS is studied involves tDCS.


Eligibility criteria: Inclusion Criteria:

* Normal hearing and vision

Exclusion Criteria:

* Left-handedness
* History of seizure, head injury (including neurosurgery), brain injury, diagnosis or a neurological or psychiatric disorder, metal in the head, sensitive scalp
* History of anxiolytic and/or antidepressant medications
* Participation in Experiment #1 or Experiment #2 of the larger study

Primary outcomes:
measure: Avoidance-Approach time difference
timeFrame: 1 year
Secondary outcomes:
Other outcomes:
Locations:
city: Medford
country: United States
facility: Center for Applied Brain and Cognitive Sciences
state: Massachusetts
Study officials:
References: