Clinical trial NCT05242380: Exercise Training in Patients With Pulmonary Arterial Hypertension
Official title: The Effects of Kettlebell Exercise Training in Patients With Pulmonary Arterial Hypertension
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Pulmonary Arterial Hypertension
Lead sponsor: Saglik Bilimleri Universitesi
Sponsor class: OTHER
Collaborators: name: Istanbul University - Cerrahpasa
First posted: 2022-02-16
Enrollment: 32
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: In this study, the effects of kettlebell exercise training on functional capacity, dyspnea and activities of daily living in patients diagnosed with Pulmonary Arterial Hypertension (PAH) will be investigated.


Eligibility criteria: Inclusion Criteria:

* Patients diagnosed with pulmonary arterial hypertension (PAH) by a specialist physician in accordance with the 2015 guideline for the treatment and diagnosis of pulmonary hypertension of the European Heart and Respiratory Societies (ERS/ESC),
* Patients with stable pharmacological treatment,
* Patients clinically stable at least last three months.

Exclusion Criteria:

* Presence of orthopedic or neurological problems that will affect functional tests and muscle strength measurement,
* Recent surgical procedures,
* Recent syncope,
* Pregnancy,
* Presence of severe left heart failure,
* Presence of severe ischemic heart disease,
* Hypertensive patients,
* Patients who have problems in communicating.

Primary outcomes:
measure: Task related oxygen uptake
timeFrame: 8 weeks
measure: Functional capacity
timeFrame: 8 weeks
measure: Peripheral muscle strength
timeFrame: 8 weeks
measure: Handgrip strength
timeFrame: 8 weeks
Secondary outcomes:
measure: Activity status
timeFrame: 8 weeks
measure: Health-related quality of life
timeFrame: 8 weeks
measure: Activities of daily living
timeFrame: 8 weeks
measure: Sleep quality
timeFrame: 8 weeks
Other outcomes:
Locations:
city: Istanbul
country: Turkey
facility: Istanbul University - Cerrahpasa, Institute of Cardiology
Study officials:
affiliation: Istanbul University - Cerrahpasa
name: Rengin Demir, PhD, PT
role: STUDY_DIRECTOR
References:
citation: Chen HT, Wu HJ, Chen YJ, Ho SY, Chung YC. Effects of 8-week kettlebell training on body composition, muscle strength, pulmonary function, and chronic low-grade inflammation in elderly women with sarcopenia. Exp Gerontol. 2018 Oct 2;112:112-118. doi: 10.1016/j.exger.2018.09.015. Epub 2018 Sep 20.
citation: Spruit MA, Wouters EF, Eterman RM, Meijer K, Wagers SS, Stakenborg KH, Uszko-Lencer NH. Task-related oxygen uptake and symptoms during activities of daily life in CHF patients and healthy subjects. Eur J Appl Physiol. 2011 Aug;111(8):1679-86. doi: 10.1007/s00421-010-1794-y. Epub 2011 Jan 6.
citation: Mapelli M, Salvioni E, Bonomi A, Gugliandolo P, De Martino F, Vignati C, Berna G, Agostoni P. How Patients With Heart Failure Perform Daily Life Activities: An Innate Energy-Saving Strategy. Circ Heart Fail. 2020 Nov;13(11):e007503. doi: 10.1161/CIRCHEARTFAILURE.120.007503. Epub 2020 Nov 17.
citation: Mereles D, Ehlken N, Kreuscher S, Ghofrani S, Hoeper MM, Halank M, Meyer FJ, Karger G, Buss J, Juenger J, Holzapfel N, Opitz C, Winkler J, Herth FF, Wilkens H, Katus HA, Olschewski H, Grunig E. Exercise and respiratory training improve exercise capacity and quality of life in patients with severe chronic pulmonary hypertension. Circulation. 2006 Oct 3;114(14):1482-9. doi: 10.1161/CIRCULATIONAHA.106.618397. Epub 2006 Sep 18.