Clinical trial NCT06750328: Outcomes of Isolated LCx Occlusion
Official title: Procedural and Clinical Outcomes of Isolated Left Circumflex Coronary Artery Acute Occlusion in Patients Undergoing Primary Percutaneous Coronary Intervention
Study type: OBSERVATIONAL
Overall status: NOT_YET_RECRUITING
Conditions: LCx Occlusion STEMI
STEMI
Keywords: LCx occlusion STEMI
Lead sponsor: Assiut University
Sponsor class: OTHER
First posted: 2024-12-27
Enrollment: 50
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: RETROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: Baseline demographic, angiographic and clinical data, including cardiovascular risk factors, will be retrospectively collected. For follow up, we will contact every patient included in our study to ask about MACE.

Brief summary: To assess procedural success and short term clinical outcomes of primary PCI to isolated LCx acute occlusion.

Detailed description: ST-segment elevation myocardial infarction (STEMI) involving acute occlusion of the left circumflex (LCx) coronary artery represent only 14-21% of STEMIs

LCx acute occlusion may be difficult to be diagnosed . Only 50% of patients with LCx occlusion exhibited ST segment elevation during the acute phase, 38% showed no ST segment changes, while 15% presented with isolated ST segment depression This may lead to delay in transfer to cath lab, delay in reperfusion therapy and consequently loss of more myocytes and more major adverse cardiovascular events (MACE) .

Due to relative rare occurrence of isolated LCx coronary artery occlusion, little is known in literature about the clinical outcomes of isolated LCx occlusion , so we will conduct a retrospective observational study in our tertiary primary percutaneous coronary intervention (PCI) center to detect the incidence , procedural and clinical outcomes after 6 months of patients who had isolated LCx acute occlusion and underwent primary PCI.

Eligibility criteria: Inclusion Criteria:

* Patients presented to Assiut University heart hospital with STEMI who underwent primary PCI that revealed isolated LCx acute occlusion (single culprit artery) between January 2018 to January 2025 will be included.

Exclusion Criteria:

-Patients with cardiogenic shock, NYHA class III-IV and multivessel coronary artery disease will be excluded.

Primary outcomes:
measure: Complications of PPCI to LCx occlusion
timeFrame: 6 months
Secondary outcomes:
measure: Long follow up of outcomes of PPCI of LCx outcomes
timeFrame: 6 months
Other outcomes:
Locations:
Study officials:
References:
citation: Geffin R, Triska J, Najjar S, Berman J, Cruse M, Birnbaum Y. Why do we keep missing left circumflex artery myocardial infarctions? J Electrocardiol. 2024 Mar-Apr;83:4-11. doi: 10.1016/j.jelectrocard.2023.12.011. Epub 2023 Dec 26.
citation: From AM, Best PJ, Lennon RJ, Rihal CS, Prasad A. Acute myocardial infarction due to left circumflex artery occlusion and significance of ST-segment elevation. Am J Cardiol. 2010 Oct 15;106(8):1081-5. doi: 10.1016/j.amjcard.2010.06.016.
citation: Stribling WK, Kontos MC, Abbate A, Cooke R, Vetrovec GW, Dai D, Honeycutt E, Wang TY, Lotun K. Left circumflex occlusion in acute myocardial infarction (from the National Cardiovascular Data Registry). Am J Cardiol. 2011 Oct 1;108(7):959-63. doi: 10.1016/j.amjcard.2011.05.027. Epub 2011 Aug 4.