Clinical trial NCT01819337: The Influence of Preoperative Cardiopulmonary Capacity on the Perioperative Lactate Level
Official title: The Influence of Preoperative Cardiopulmonary Capacity Mesured in MET's (Metabolic Equivalents) on the Perioperative Lactate Level
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Sensitivity Training Groups
Complication, Cardio-respiratory
Lead sponsor: University of Witten/Herdecke
Sponsor class: OTHER
First posted: 2013-03-27
Enrollment: 1502
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: All patients undergoing elective/urgent or emergency surgery

Brief summary: The aim of this study is to identify if there exists a correlation between the preoperative cardiopulmonary capacity - measured in MET's - and the perioperative lactate serum level.

Detailed description: The determination of the cardiopulmonary (c/p) capacity is very important for the evaluation of every patient undergoing surgery. The ability to climb at least two flight of stairs is seen to be an acceptable c/p capacity for surgery. There are several ways to evaluate the fitness of patients. A common method to estimate the cardiopulmonary capacity is defining patients through the MET's (metabolic equivalents) scale. MET's can be defined relatively easy through a simple questionnaire. Patients with a reduced c/p capacity have less than 4 MET's, patients with a relatively good c/p capacity have 4-10 MET's and patients with a excellent c/p capacity have more than 10 MET's.

The lactate level in blood serum is a common parameter to asses anaerobic metabolism in patients. A high lactate level correlates with higher mortality rates and outcome.

To yet it is not clear if there exists a correlation between the preoperative cardiopulmonary capacity measured in MET's and the perioperative lactate level. We hypothysed that patients with a reduced cardiopulmonary capacity are associated with higher perioperative lactate levels, as these group of patients compensate the stressors operation/anesthesia less than patients with a good c/p capacity.

Eligibility criteria: Inclusion Criteria:

* Age \> 18 years

Exclusion Criteria:

* Cardiac surgery

Primary outcomes:
measure: lactate - venous blood gas analysis
timeFrame: venous lactate will be measured at anaesthesia induction and anesthesia termination - the average time frame is 2 hours
Secondary outcomes:
measure: icu in hospital mortality
timeFrame: icu patients will be followed over their hospital stay over a maximum period of 6 months
measure: hemoglobin - venous blood gas analysis
timeFrame: hemoglobin will be measured at anaesthesia induction and anesthesia termination - the average time frame is 2 hours
measure: icu ventilation time
timeFrame: icu patients will be followed over their hospital stay over a maximum period of 6 months
Other outcomes:
Locations:
city: Wuppertal
country: Germany
facility: Helios Klinikum Wuppertal
state: NRW
Study officials:
affiliation: Dept. Anaesthesiology
name: Gerhard Schneider, Prof.
role: STUDY_CHAIR
References: