Clinical trial NCT05806229: Ultrasound- Guided Mid Point Transverse Process to Pleura Block
Official title: Ultrasound- Guided Mid Point Transverse Process to Pleura Block: Does It Decreases the Incidence of Acute and Chronic Post Nephrectomy Pain? Randomized Controlled Study.
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Regional Anesthesia for Postnephrectomy Pain
Keywords: nephrectomy pain
Lead sponsor: Tanta University
Sponsor class: OTHER
First posted: 2023-04-10
Enrollment: 70
Sex: ALL
Minimum age (years): 21
Maximum age (years): 65
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Intervention model description: prospective randomized controlled trial
Primary purpose: TREATMENT

Brief summary: Radical nephrectomy is the surgical process for the resection of malignant tumors of the kidney necessitating a subcostal flank incision.Mild to severe pain is observed in the postoperative period Ineffective pain management leads to several complications. The mid point transverse process to pleura block (MTP) , this technique was used for pain relief after mastectomy, thoracic, abdominal, and spinal surgery and was found effective due to its simplicity and lower risks compared to epidural analgesia.

Detailed description: Ineffective pain management leads to several complications including immobilization, thromboembolism, persisting chronic pain, increased opioid consumption, and delayed hospital discharge.\[3\]

Multimodal analgesic (MMA) regimens using several drugs and techniques are considered to be necessary for postoperative pain relief. Regional anesthesia techniques, mainly epidural analgesia and more recently, paravertebral blocks became crucial parts of a MMA regimen after the introduction of ultrasound (US) in the regional anesthesia practice.

The mid point transverse process to pleura block (MTP) block was first described as a modified paravertebral block in 2017. The local anesthetic drugs are administered between the transverse process and the pleura. This results in a local anesthetic drugs spread to the dorsal and ventral rami in the paravertebral space through the fenestrations in the superior costotranverse ligament (SCTL) at the level of injection, and frequently to adjacent levels.

This technique was used for pain relief after mastectomy, thoracic, abdominal, and spinal surgery and was found effective due to its simplicity and lower risks compared to epidural analgesia.

Eligibility criteria: * Inclusion Criteria: - ASA II and III patients
* scheduled for partial or radical nephrectomy
* standard flank incision either subcostal ,intercostal or supracostal approach
* under general anesthesia.

Exclusion Criteria:

* Bleeding disorders,
* Mental or cognitive dysfunction,
* History of chronic analgesic or drug abuse,
* Allergy to local anesthetics
* Local infection at site of block

Primary outcomes:
measure: Assessment of acute post nephrectomy pain
timeFrame: the first postoperative day
Secondary outcomes:
measure: chronic post nephrectomy pain development.
timeFrame: the first postoperative 3 monthes
Other outcomes:
Locations:
city: Tanta
country: Egypt
facility: Tanta university
Study officials:
affiliation: Tanta University
name: Aliaa Belal, lecturer
role: PRINCIPAL_INVESTIGATOR
References: