Clinical trial NCT01598207: The Effects of Cannabinoid on Patients With Non-GERD Related Non Cardiac Chest Pain
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE4
Conditions: Chest Pain
Lead sponsor: University of Iowa
Sponsor class: OTHER
First posted: 2012-05-15
Enrollment: 13
Sex: ALL
Minimum age (years): 18
Maximum age (years): 75
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: Background: Noncardiac chest pain (NCCP) affects 200,000 new cases annually in USA. It is associated with poor quality of life and high health care expenditure of 8 Billion Dollars a year.

Gastroesophageal Reflux Disease(GERD), esophageal motility disorders, and psychological issues may cause NCCP.

The mechanism(s) for pain continue to be explored and include central and peripheral hypersensitivity, and mechanophysical abnormalities. Treatment of NCCP has focused on relieving visceral hypersensitivity through pain modulators, such as tricyclics, trazodone, or adenosine receptor antagonist, theophylline. Typically, only 40-50 % respond and clearly there is a large unmet therapeutic need.

Cannabis is felt to be beneficial for vomiting, diarrhea and intestinal pain. The main component of Cannabis acts through specific receptors, that are located primarily on central and peripheral neurons (including the enteric nervous system) and myenteric plexus where they modulate neurotransmitter release. Activation of these receptors reduces excitatory enteric transmission and may improve esophageal hyperreactivity and hypersensitivity, the hallmarks of NCCP.

STUDY PROTOCOL: The investigators will randomize 40 subjects with non-cardiac, non-reflux chest pain to receive dronabinol (5 mg Bid), or placebo for 4 weeks. Chest pain symptoms and esophageal sensorimotor properties will be assessed at baseline and at 4 weeks using symptom diary and impedance planimetry. The primary outcome measure will be the frequency of chest pain episodes. Secondary outcome measures include improvement in esophageal sensory thresholds, reduced reactive contractions, frequency, amplitude, area under the curve, and global improvement of symptoms.

HYPOTHESIS: Cannabinoids decrease esophageal hypersensitivity and ameliorate chest pain in NCCP patients, when compared to placebo.

AIM: To perform a randomized double blind study to investigate the effects of Dronabinol, a CB1 and CB2 agonist, in the treatment of patients with NCCP and examine its mechanism of action.


Eligibility criteria: Inclusion Criteria:

* Male or Female
* Ages 18-75 years
* Non-GERD related Non cardiac chest pain (Evaluated previously with an EGD, Esophageal manometry, and 24 Hour ambulatory pH study)
* At least one episode of chest pain a week in the past month
* Previous negative cardiac evaluation (EKG ± Non invasive stress test ± Coronary angiogram)

Exclusion Criteria:

* Subjects requiring narcotics or other pain medications
* Subjects with known esophagitis, Barrett's esophagus or peptic stricture on endoscopy
* Subjects with previous upper gastrointestinal surgery
* Pregnancy
* Subjects with Diabetes, neuromuscular disorders, or other severe co-morbidities (Cardiovascular, respiratory, renal, hepatic, hematologic, endocrine, neurologic, and psychiatric)
* Subjects with upper airway symptoms (such as hoarseness, wheezing or laryngospasm)
* Medications such as baclofen, H2 blockers, PPI, sucralfate and prokinetics.
* Known history of substance abuse
* Nursing mothers

Primary outcomes:
measure: Frequency of Chest Pain Episodes
timeFrame: Baseline and 1 month
Secondary outcomes:
measure: Frequency of Chest Pain in Treatment Group vs Baseline
timeFrame: 1 month
measure: Intensity of Chest Pain Episodes
timeFrame: Baseline and 1 month
measure: Sensory Thresholds for First Sensation
timeFrame: Baseline and 1 month
measure: Duration of Chest Pain Episodes
timeFrame: Baseline vs 1 month
measure: Sensory Thresholds for Discomfort
timeFrame: Baseline and 1 month
measure: Sensory Thresholds for Pain
timeFrame: Baseline and 1 month
Other outcomes:
Locations:
city: Iowa City
country: United States
facility: University of Iowa Hospitals and Clinics
state: Iowa
Study officials:
References:
citation: Reichenbach ZW, Sloan J, Rizvi-Toner A, Bayman L, Valestin J, Schey R. A 4-week pilot study with the cannabinoid receptor agonist dronabinol and its effect on metabolic parameters in a randomized trial. Clin Ther. 2015 Oct 1;37(10):2267-74. doi: 10.1016/j.clinthera.2015.07.023. Epub 2015 Aug 14.