Clinical trial NCT06349707: Multiplex PCR for Severe Respiratory Infections During the COVID-19 Pandemic
Official title: Relevance of the Multiplex PCR Approach for Severe Respiratory Infections of Patients Hospitalized - Including an Intensive Care Unit, During the COVID-19 Pandemic
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Viral Pneumonia
Keywords: respiratory virus
Lead sponsor: Central Hospital, Nancy, France
Sponsor class: OTHER
First posted: 2024-04-05
Enrollment: 18
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: ECOLOGIC_OR_COMMUNITY
Time perspective: RETROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: 18 Intensive Care Unit (ICU)-patients, from the whole population of patients who were hospitalized for respiratory infections from early 2021 to mid-2022 in Nancy University hospital, France:

* from the results of the multiplex FilmArrays PCR tests carried out during the 18 months of the study;
* for the ICU files, 18 patients positive for virus by the FilmArray Pneumonia test: ICU patients (or representatives) informed of the data collection that can be used for research (ICCA db)

Brief summary: The hypothesis was that a retrospective investigation of the molecular virological tests in a University hospital could be informative, with the aim to identify non-COVID-19 respiratory viruses during the circulation of SARS-CoV-2, according to systematic population data for public health knowledge.

Detailed description: The hypothesis was that a retrospective investigation of the molecular virological tests in a University hospital could be informative, with the aim to identify non-COVID-19 respiratory viruses during the circulation of SARS-CoV-2, according to systematic population data for public health knowledge:

* the main goal was to perform a retrospective investigation of the molecular virological tests in a University hospital, in order to identify non-COVID-19 respiratory viruses from the beginning of 2021 to mid-2022 during the circulation of SARS-CoV-2, for public health knowledge;
* the secondary aim was to retrospectively analyze, for a small subgroup of patients from an intensive care unit, the files of patients with positive molecular virological tests for non-COVID-19 respiratory viruses from the beginning of 2021 to mid-2022, reporting the following standard-of-care data: (i) the identification of the viruses, (ii) bioclinical features, (iii) medical impact of virological results in real life.

Eligibility criteria: Inclusion Criteria:

* For adult patients, or minors 'via' parents, able to give consent - 18 intensive care patients

Exclusion Criteria:

* Non-inclusion in case of refusal

Primary outcomes:
measure: Occurrence of positive viral PCR assays (not COVID-19) from hospitalizations for respiratory infections.
timeFrame: 18 months, retrospectively
Secondary outcomes:
measure: Real-life features of patients in Intensive care (from the whole population - Outcome 1) with positive viral PCR during infectious pneumonia.
timeFrame: 18 months, retrospectively
Other outcomes:
Locations:
city: Vandoeuvre Les Nancy
country: France
facility: Schvoerer
Study officials:
References: