Clinical trial NCT03416088: Influence of Daily Activities on Retinal Microcirculation
Official title: The Influence of Daily Activities on Retinal Microcirculation in Normal Adults
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Retinal Microcirculation Disorder
Keywords: Beverage consumption
Reading
Body motion
Retinal microcirculation
Optical coherence tomography angiography
Magnetic resonance imaging
Lead sponsor: Shanghai Eye Disease Prevention and Treatment Center
Sponsor class: OTHER
First posted: 2018-01-30
Enrollment: 54
Sex: ALL
Minimum age (years): 18
Maximum age (years): 35
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: CROSSOVER
Intervention model description: 1. Influence of beverage consumption Participants drink coffee, red wine, Baijiu (Chinese liquor), grape juice, and water respectively on three mornings with one-week washout. Each period lasts 2 hours. An additional test with SipSparkTM Probiotics (facilitates ethanol degradation) was taken 0.5 hour prior to Baijiu consumption. OCTA and MRI scanning are taken every 30 minutes, and venous blood is collected.
2. Influence of daily reading 30 participants read paper books, play video games with mobile phones, and non-read respectively on three mornings interval with one-week washout. OCTA and MRI scanning are taken every 2 hours for a total of 8 hours.
3. Influence of body motion Exercise: 30 participants are enrolled. Participants undergo to jogging for 10 minutes, 30 minutes, and 1 hour respectively on three mornings with a 3-day washout. Body postural changes: 30 participants are enrolled. OCTA and MRI scanning are taken before and after jogging or body postural changes.
Primary purpose: BASIC_SCIENCE

Brief summary: The daily behaviors such as drinking coffee, wine, reading, exercise and body postural changes may have influence on the function or morphology of the retinal microcirculation in healthy people.A recent study found that the fingertips microvascular bed constricted obviously after the intake of a cup of coffee with caffeine, it significantly reduced blood flow to the fingers; Long reading of electronic products can induce significant dry eye symptoms, affect visual quality, and cause asthenopia. Microcirculation is critical for regulating vascular resistance and blood flow in organs. Fundus blood vessels is the only visible microvascular in vivo, its morphology and function changes not only associated with eye disease, but also with cardiovascular and cerebrovascular diseases. Optical coherence tomography angiography (OCTA) is a new technique which could acquire blood flow information in a non-invasive way without the use of dye. Magnetic resonance imaging (MRI) can quantitatively evaluation of cerebral blood flow and retina-choroid blood flow using the noninvasive arterial spin labeling technique in a large field of view (FOV) without depth limitations.The study tried to detect the influence of daily behaviors such as drinking coffee, red wine, reading , exercise, etc. on the retinal microcirculation with OCTA and MRI, and provide reference for health behaviors.


Eligibility criteria: Inclusion Criteria

1. Healthy adults
2. The age range was from 18 to 35 years old
3. Without another eye disease besides ametropia
4. The spherical equivalent is equal or above minus 3.00 diopters
5. No smoking or drinking
6. Average daily caffeine consumption no more than 1 cup of coffee
7. No diabetes, hypertension, heart disease, liver or kidney dysfunction
8. No medication taken recently

Exclusion Criteria

1. Mental disorders such as depression and anxiety
2. Intellectual disabilities
3. Female in menstruation, gestation period, perinatal period or lactation period
4. Unable to cooperate with eye examinations and test procedures
5. Heart disease, hypertension, diabetes, liver and kidney dysfunction and other chronic diseases
6. Patients with fever, acute infectious diseases
7. Other conditions that are not suitable for drinking alcohol or coffee, such as allergic to alcohol or coffee

Primary outcomes:
measure: Vessel diameter index (VDI)
timeFrame: 3 weeks
measure: Vessel area density (VAD)
timeFrame: 3 weeks
measure: Flow impairment region (FIR)
timeFrame: 3 weeks
measure: Retina-choroid blood flow
timeFrame: 3 weeks
measure: Cerebral blood flow (CBF)
timeFrame: 3 weeks
Secondary outcomes:
Other outcomes:
Locations:
city: Shanghai
country: China
facility: Shanghai Eye Disease Prevention & Treatment Center
state: Shanghai
Study officials:
References:
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citation: Strang NM, Claus ED, Ramchandani VA, Graff-Guerrero A, Boileau I, Hendershot CS. Dose-dependent effects of intravenous alcohol administration on cerebral blood flow in young adults. Psychopharmacology (Berl). 2015 Feb;232(4):733-44. doi: 10.1007/s00213-014-3706-z. Epub 2014 Aug 12.
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