Clinical trial NCT05387993: Microbial Keratitis in Cairo University Hospitals
Official title: Incidence, Risk Factors and Microbiological Features of Infective Keratitis in Cairo University Hospitals
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Infective Keratitis
Keywords: Corneal ulcer
Microbiological profile
Fungal keratitis
Bacterial keratitis
Infective keratitis
Antimicrobial susceptibility
Lead sponsor: Kasr El Aini Hospital
Sponsor class: OTHER
First posted: 2022-05-24
Enrollment: 85
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: CASE_ONLY
Time perspective: CROSS_SECTIONAL
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Recruitment occurred from the Ophthalmology outpatient clinics and casualty department in Cairo University Hospitals, Kasr Al Aini.

They met all inclusion and exclusion criteria for enrollment into this study.

Brief summary: The aim of the study was to identify the incidence of infective keratitis presenting to the ophthalmology emergency department at Cairo University hospital, the risk factors and the bacterial/fungal spectrum causing the ulcers and to determine the best possible empirical therapy followed by specific therapy after obtaining culture results.


Eligibility criteria: Inclusion Criteria:

* Patients presenting at the casualty who are clinically diagnosed as infectious keratitis , of all age groups and including both genders.

Exclusion Criteria:

Patients presenting with clinical picture suggestive of

* Viral keratitis solely without superimposed secondary infection.
* Non infectious keratitis as peripheral ulcerative keratitis ( e.g. Mooren's ulcer, marginal keratitis, autoimmune keratitis )

Primary outcomes:
measure: To identify risk factors and the most common causative organisms of microbial keratitis among the Egyptian population through history taking from each patient and the results of corneal sampling taken from the ulcer.
timeFrame: Three weeks for each participant
measure: To detect incidence of infective keratitis amongst all ophthalmological casualty cases by documenting the number of cases presenting or referred to the casualty of the ophthalmology department.
timeFrame: through study completion, an average of eight months
measure: To detect antimicrobial susceptibility and resistance of different antimicrobial agents causing corneal infections in our study group.
timeFrame: two weeks for each participant
Secondary outcomes:
measure: To assess the impact of culture and sensitivity results of corneal scrapings on the initial empirical therapy by calculating the number of cases that needed to shift the initial therapy to another one according to the antimicrobial susceptibility.
timeFrame: six months
measure: Improving lines of management of microbial keratitis for a better outcome based on the cooperation between clinical ophthalmologists and microbiologists to reach a proper diagnosis and tailor the management accordingly.
timeFrame: six months
Other outcomes:
Locations:
city: Cairo
country: Egypt
facility: Kasr Al Aini Hospital
Study officials:
affiliation: Kasr Al Aini Hospital
name: Yehia Mostafa, MD
role: STUDY_CHAIR
affiliation: Kasr Al Aini Hospital
name: Mohamed El Agha, MD
role: STUDY_DIRECTOR
affiliation: Kasr Al Aini Hospital
name: Ihab Othman, MD
role: STUDY_DIRECTOR
affiliation: Kasr Al Aini Hospital
name: Moushira Hosny, MD
role: STUDY_DIRECTOR
affiliation: Kasr Al Aini Hospital
name: Nevien Lotfy, MSc
role: PRINCIPAL_INVESTIGATOR
References: