Clinical trial NCT04728932: LEVOSIMENDAN to Facilitate Weaning From ECMO in Severe Cardiogenic Shock Patients
Official title: LEVOSIMENDAN to Facilitate Weaning From ECMO in Severe Cardiogenic Shock Patients
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE3
Conditions: Cardiogenic Shock
Extracorporeal Membrane Oxygenation Complication
Keywords: LEVOSIMENDAN
Lead sponsor: Assistance Publique - Hôpitaux de Paris
Sponsor class: OTHER
First posted: 2021-01-28
Enrollment: 206
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: In the last decade, venoarterial extracorporeal membrane oxygenation (VA-ECMO) has become the first-line therapy in patients with refractory cardiogenic shock. VA-ECMO provides both respiratory and cardiac support, is easy to insert, even at the bedside, provides stable flow rates, and is associated with less organ failure after implantation compared to large biventricular assist-devices that require open-heart surgery. In patients with potentially reversible cardiac failure (e.g. myocarditis, myocardial stunning post-myocardial infarction, post-cardiotomy or post-cardiac arrest), VA-ECMO might be weaned after a few days of support and used as a bridge to recovery.

Although considered as the ultimate life-saving technology for refractory cardiac failure, veno-arterial ECMO is still associated with severe complications. Specifically, excessive LV afterload and lack of LV unloading under VA-ECMO might induce LV stasis with thrombus formation, pulmonary edema, myocardial ischemia caused by ventricular distension and ultimately increase mortality. ECMO support also exposes to many complications such as infections, hemorrhage or peripheral vascular embolism. These complications are more frequent with prolonged support and are responsible for significant morbidity and mortality, prolonged ICU and hospital stays and higher costs.

Levosimendan, which acts to sensitize myocardial contractile proteins to calcium, improves cardiac contractility without increasing the intracellular calcium concentration. Unlike traditional inotropes such as dobutamine, levosimendan neither increases myocardial oxygen consumption nor impairs diastolic function or possess proarrhythmic effects. It also influences the opening of ATP-dependent potassium channels, including those in vascular smooth muscle cells, leading to coronary, pulmonary, and peripheral vasodilation and antiinflammatory, antioxidative, antiapoptotic, anti-stunning and cardioprotective effects. Additionally, Levosimendan which has a long lasting action (up to 7-9 d), resulting from the formation of active metabolite, may be used as a single 24h perfusion.

In recent preliminary studies, the drug was associated with accelerated weaning from VA-ECMO and even improved survival. Therefore, a multicenter randomized trial with sufficient statistical power is needed in refractory cardiogenic shock patients supported by VA-ECMO to test if the early administration of Levosimendan can facilitate and accelerate VA-ECMO weaning, and ultimately translate in significantly less morbidity, reduced ICU and hospital length of stays and associated costs.


Eligibility criteria: Inclusion Criteria:

1. Acute cardiogenic shock patient refractory to conventional therapy placed on VA-ECMO support in the preceding 48h.
2. Obtain informed consent from a close relative or surrogate. According to the specifications of emergency consent, randomization without the close relative or surrogate consent could be performed. Close relative/surrogate/family consent will be asked as soon as possible. The patient will be asked to give his/her consent for the continuation of the trial when his/her condition will allow.

Exclusion Criteria:

1. Age \<18
2. Pregnant or lactating women
3. Initiation of VA-ECMO \>48 h
4. Resuscitation \>30 minutes in the 48 hours before ECMO (cumulative low-flow time). If a low-flow episode occurs before the 48 hours window prior to ECMO, patients must fully recover consciousness to be randomized.
5. Irreversible neurological pathology
6. End-stage cardiomyopathy with no hope of LV function recovery
7. Mechanical complication of myocardial infarction
8. Aortic regurgitation \> II
9. VA-ECMO for pulmonary embolism
10. VA-ECMO for cardiotoxic drug intoxication
11. ECMO after left-ventricle assist device implantation
12. VA-ECMO in heart transplant patients
13. Patient moribund on the day of randomization, SAPS II \>90
14. Liver cirrhosis (Child B or C) and other severe hepatic insufficiency
15. Chronic renal failure requiring hemodialysis
16. Known hypersensitivity to levosimendan
17. History of torsades de pointes in the 30 days prior to inclusion
18. History of epilepsy
19. Individuals under guardianship, or permanently legally incompetent adults
20. Participation to another interventional study
21. Patient with a weight over 180 kg
22. Known hypersensitivity to polyvitamin CERNEVIT®
23. In case of hypervitaminosis to any vitamin contained in this formulation,
24. In case of severe hypercalcemia, hypercalciuria, treatment, pathology and/or disorders leading to severe hypercalcemia and/or hypercalciuria
25. In combination with vitamin A or retinoids

Primary outcomes:
measure: Time to successful ECMO weaning within the 30 days following randomization
timeFrame: Day 30
Secondary outcomes:
measure: Mortality
timeFrame: Day 30, Day 60
measure: Total duration of ECMO support
timeFrame: Between inclusion and Day 30/Day 60
measure: Number of ECMO-free days
timeFrame: Between inclusion and Day 30/Day 60
measure: Duration of ICU stay
timeFrame: Between inclusion and Day 60
measure: Duration of hospitalization stay
timeFrame: Between inclusion and Day 60
measure: Major adverse cardiovascular events
timeFrame: Day 30, Day 60
measure: Time to improvement in hemodynamic parameters
timeFrame: Between inclusion and Day 60
measure: Time to hemodynamic stabilization
timeFrame: Between inclusion and Day 60
measure: Days with organ failure asessed by sequential organ failure assessment
timeFrame: Between inclusion and Day 30
measure: Duration of hemodynamic support with catecholamines
timeFrame: Between inclusion and Day 30/Day 60
measure: Number of days alive without hemodynamic support
timeFrame: Between inclusion and Day 30/Day 60
measure: Duration of mechanical ventilation
timeFrame: Between inclusion and Day 30/Day 60
measure: Number of days alive without mechanical ventilation
timeFrame: Between inclusion and Day 30/Day 60
measure: Left ventricular function assessed with echocardiography
timeFrame: Day 30
measure: Incidence of adverse drug reactions
timeFrame: Between inclusion and Day 60
Other outcomes:
Locations:
city: Pessac
country: France
facility: Hôpital du Haut-Lévêque
state: Bordeaux
city: Paris
country: France
facility: Hôpital Pitié Salpêtrière
city: Paris
country: France
facility: Hôpital Européen Georges Pompidou
Study officials:
References: