Clinical trial NCT05353270: Effects of Yoga on Sodium-induced Pressor Responses in African American Adults
Official title: Effects of Yoga on Pressor and Endothelial Function in Responses to Sodium Loading in African American Adults
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Blood Pressure
Keywords: Blood pressure
Salt sensitivity
Lead sponsor: Texas State University
Sponsor class: OTHER
First posted: 2022-04-29
Enrollment: 15
Sex: ALL
Minimum age (years): 18
Maximum age (years): 60
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: CROSSOVER
Primary purpose: TREATMENT

Brief summary: This investigation aims to determine the effects of a 4-week yoga intervention on sodium-induced pressor and endothelial function responses as well as markers of renal sodium handling in African American adults.


Eligibility criteria: Inclusion Criteria:

* African American
* Adults ages 18-60 years

Exclusion Criteria:

* pregnancy or within 60 days postpartum
* having taken blood pressure (including diuretics beta-blockers, ACE inhibitors, angiotensin receptor blockers, and calcium channel blockers) or statin medications within the past 3 months (statins have been demonstrated to reduce oxidative stress which could impact flow-mediated dilation);
* infection (viral or other) within the past 4 weeks;
* having adrenal or endocrine tumors (these could impact BP);
* renal disease defined as a glomerular filtration rate (GFR) of less than 60 (creatinine will be tested at initial screening and GFR will be calculated);
* prior myocardial infarction; vii) known coronary heart disease;
* personal history of stroke;
* heart failure;
* cardiac arrhythmias;
* chronic obstructive pulmonary disease;
* recent chest pain or dyspnea;
* orthopedic limitations that preclude the execution of yoga postures;
* current insulin dependence;
* currently taking steroid medications;
* currently undergoing chemotherapy or radiation;
* having practiced yoga or yogic breathing techniques at least once weekly consistently within the past 3 months;
* heat intolerance or electrolyte imbalances (hypo- or hyper-natremia or hypo- or hyper-kalemia).

Primary outcomes:
measure: Change in blood pressure from low- to high-sodium dietary conditions
timeFrame: Measurements will be completed after 3 days of low and 3 days of high sodium intake at baseline and after 4 weeks for both conditions.
measure: Change in endothelial function from low- to high-sodium dietary conditions.
timeFrame: Measurements will be completed after 3 days of low- and 3 days of high-sodium intake at baseline and at week 4.
measure: Change in arterial stiffness from low- to high-sodium dietary conditions.
timeFrame: Measurements will be completed after 3 days of low- and 3 days of high-sodium intake at baseline and at week 4.
Secondary outcomes:
measure: Change in urinary sodium excretion from low- to high-sodium dietary conditions.
timeFrame: Measurements will be completed after 3 days of low- and 3 days of high-sodium intake at baseline and at week 4.
Other outcomes:
Locations:
city: San Marcos
country: United States
facility: Cardiovascular Physiology Laboratory-Texas State University
state: Texas
Study officials:
References: