louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT00002052: Prospective Comparison of Ampicillin / Amoxicillin Versus Ceftriaxone for the Treatment of Salmonella Infections in AIDS Patients
Official title: Prospective Comparison of Ampicillin / Amoxicillin Versus Ceftriaxone for the Treatment of Salmonella Infections in AIDS Patients
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: HIV Infections
Salmonella Infections
Keywords: Salmonella Infections
AIDS-Related Opportunistic Infections
Acquired Immunodeficiency Syndrome
Amoxicillin
Ceftriaxone
Lead sponsor: NIH AIDS Clinical Trials Information Service
Sponsor class: INDUSTRY
First posted: 2001-08-31
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Primary purpose: TREATMENT

Brief summary: To compare the effectiveness of standard treatment with parenteral ampicillin and oral amoxicillin compared to initial daily therapy with ceftriaxone followed by 3 times weekly suppressive treatment for salmonella infections in AIDS patients.


Eligibility criteria: Exclusion Criteria

Co-existing Condition:

Patients with the following are excluded:

* Type I hypersensitivity to beta-lactam antibiotics.
* Not expected to survive 12 weeks.
* In a coma or with other central nervous system (CNS) impairment.

Patients with the following are excluded:

* Type I hypersensitivity to beta-lactam antibiotics.
* Not expected to survive 12 weeks.
* In a coma or with other central nervous system (CNS) impairment.

Prior Medication:

Excluded within 48 hours of study entry:

* Treatment with an antibiotic active in vitro against Salmonella.

HIV infection, AIDS, or AIDS related complex (ARC).

* Salmonella bacteremia or positive stool culture in patient with 3 or more stools per day.

Primary outcomes:
Secondary outcomes:
Other outcomes:
Locations:
city: Los Angeles
country: United States
facility: Los Angeles County - USC Med Ctr
state: California
Study officials:
References:
Clinical trial NCT00054652: Survey of Sensory and Motor Tricks in Focal Dystonia
Official title: Survey of Sensory and Motor Tricks in Focal Dystonia
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Focal Dystonia
Keywords: Geste Antagoniste
TMS
Sensorimotor Integration
Writer's Cramp
Sensory Input
Focal Dystonia
Lead sponsor: National Institutes of Health Clinical Center (CC)
Sponsor class: NIH
First posted: 2003-02-06
Enrollment: 80
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no

Brief summary: This study will collect information on (tricks) patients with focal dystonia use to relieve their symptoms. Dystonia is a movement disorder caused by sustained muscle contractions often causing twisting and abnormal posturing. Dystonia may be generalized, affecting at least one leg and the trunk of the body, segmental, affecting adjacent body parts, or focal, affecting a single body part, such as the hand or eyelid. It may be task-specific, such as writer's, musician's or sportsman's cramps. Some patients with focal dystonia use (tricks), such as touching the face or hand, to stop or alleviate the abnormal movement. This study will survey the types of tricks people with focal dystonia use in order to learn more about the disorder.

Patients 18 years of age and older with focal dystonia may be eligible for this study. Candidates will be screened for eligibility with a medical history, clinical evaluation, and review of their medical records.

In one 30- to 45-minute clinic visit, participants will be interviewed about their dystonia symptoms and the tricks they use to relieve the symptoms. They may be asked to show the investigators how the tricks work

Detailed description: The purpose of this study is to collect and organize information concerning a phenomenon known as 'sensory tricks' or Geste antagoniste in focal dystonia. Sensory tricks, which we will refer to as 'tricks' since some involve motor as well as sensory input, are various stimuli used by dystonic patients to transiently diminish their spasms (Jankovic and Fahn 1993). The phenomenon of tricks is evidence for the abnormality of sensorimotor integration in focal dystonia, yet it is little studied or understood. A survey of the history and characteristics of tricks will lead to a better understanding of this puzzling phenomenon, and a step toward the understanding of the mechanism of focal dystonia.

Eligibility criteria: INCLUSION CRITERIA

Patients with focal dystonia diagnosed by review of medical record, history, and clinical evaluation.

EXCLUSION CRITERIA

Any individual without focal dystonia.

Any individual who is unable to provide accurate history, or is critically ill.

Primary outcomes:
Secondary outcomes:
Other outcomes:
Locations:
city: Bethesda
country: United States
facility: National Institute of Neurological Disorders and Stroke (NINDS)
state: Maryland
Study officials:
References:
Clinical trial NCT06090552: I CAN DO Surgical ACP
Official title: I CAN DO Surgical ACP (Improving Completion, Accuracy, and Dissemination of Surgical Advanced Care Planning) Trial
Study type: INTERVENTIONAL
Overall status: ENROLLING_BY_INVITATION
Phase: NA
Conditions: Surgical Advanced Care Planning
Lead sponsor: University of California, San Francisco
Sponsor class: OTHER
Collaborators: name: University of California, Irvine
name: University of Minnesota
name: National Institute on Aging (NIA)
First posted: 2023-10-19
Enrollment: 6000
Sex: ALL
Minimum age (years): 65
Standard ages: OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: SINGLE_GROUP
Intervention model description: 1:1:1 simple randomized block design stratified by enrollment site
Primary purpose: SUPPORTIVE_CARE

Brief summary: The goal of the Advanced Care Planning (ACP) study is to encourage patients aged 65 or older who are referred for elective surgery to have advanced care planning.

Detailed description: ACP is also a critical way to support older adults in participating actively with clinicians in making real-time, complex medical decisions so that the medical care they receive is aligned with their goals. Our team has designed and tested a theory-based, interactive ACP patient-facing technology solution (PREPARE) based on the new ACP paradigm of preparing people for communication and medical decision-making. The study team hypothesizes that by including PREPARE into the electronic health record (EHR)-centric pre-surgery workflow for older adults and including automated reminders, the study team can empower patients and surgical teams to engage in ACP discussions.

Participants will be randomized to Arms: (1) Letter about ACP, PREPARE advanced directive (AD), PREPARE website; (2) Letter, advanced directive (AD), PREPARE plus reminder messages; (3) Letter, advanced directive (AD,) PREPARE plus reminders plus a healthcare navigator on ACP documentation (clinically meaningful ACP, primary outcome). All patients randomized to the intervention will be sent a patient-reported ACP engagement survey (secondary outcome).

Eligibility criteria: Inclusion Criteria:

- Older Adults (age 65+) referred for surgical evaluation

Exclusion Criteria:

1. ACP on file within 3 years prior to surgery (UCSF and UCI) and 5 years (UMN)
2. Was previously randomized into intervention for a prior surgery during the 18-month study period

Primary outcomes:
measure: Number of participants with clinically meaningful Advanced Care Planning
timeFrame: 6 months
Secondary outcomes:
measure: Patient Engagement Scores
timeFrame: 6 months
Other outcomes:
Locations:
city: Irvine
country: United States
facility: University of California, Irvine
state: California
city: San Francisco
country: United States
facility: University of California, San Francisco
state: California
city: Minneapolis
country: United States
facility: University of Minnesota
state: Minnesota
Study officials:
affiliation: University of California, San Francisco
name: Elizabeth Wick, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT03096652: A Modified Approach for Morbid Obese With Gynecologic Cancer
Official title: Gynecologic Cancer: a Modified Approach for Morbid Obese Patients
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Malignant Neoplasm of Cervix, Endometrium and Ovary
Keywords: gynecologic cancer - panniculectomy
Lead sponsor: Mansoura University
Sponsor class: OTHER
First posted: 2017-03-30
Enrollment: 100
Sex: FEMALE
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: Comparing standard midline approach with the modified approach in management of morbid obese patients with gynecologic cancers.


Eligibility criteria: Inclusion Criteria:

1. Resectable (ovarian, endometrial, cervical) cancers.
2. Anaesthetically fit (ASA 1 and 2).
3. Abdominal pannus below symphysis pubis.

Exclusion Criteria:

1. Non resectable gynecologic cancer.
2. Unfit patients.
3. Patients who refuse to share in the trial.

Primary outcomes:
measure: Oncologic outcome
timeFrame: 2 weeks
Secondary outcomes:
measure: Operative time
timeFrame: 1 day
measure: Postoperative procedure related morbidity
timeFrame: 1 month
measure: Blood loss
timeFrame: 1 day
measure: Hospital stay
timeFrame: 1 month
Other outcomes:
Locations:
city: Mansoura
country: Egypt
facility: Oncology center Mansoura University
state: Dakahlia
Study officials:
References:
Clinical trial NCT03845452: Muscle Mass or Muscle Function as a prédictive Tools for Outtcomme in Chronic Dialysis Patients
Official title: Retrospective Study : Muscle Mass or Muscle Function as a prédictive Tools for Outtcomme in Chronic Dialysis Patients
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Chrnoic Haemodialysis Patients
Keywords: chronic kidney disease
muscle strength
muscle mass
lean body mass
physical activity
Lead sponsor: University Hospital, Montpellier
Sponsor class: OTHER
First posted: 2019-02-19
Enrollment: 187
Sex: ALL
Minimum age (years): 18
Maximum age (years): 90
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: RETROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: Chrnoic haemodialysis patients

Brief summary: Aim of this study is to compare the association of muscle mass and functionality with mortality among chronic haemodialysis

* the involvement of malnutrition inflammation and atherogenesis syndrome (increase in C reactive protein and decrease in serum albumin) on voluntary muscle strength impairment and phyiscal activity.
* the relationship between voluntary muscle strength and mortality
* the relationship between voluntary muscle strength and physical activity

Detailed description: Aim of this study is to compare the association of muscle mass and functionality with mortality among chronic haemodialysis

* the involvement of malnutrition inflammation and atherogenesis syndrome (increase in C reactive protein and decrease in serum albumin) on voluntary muscle strength impairment and phyiscal activity.
* the relationship between voluntary muscle strength and mortality
* the relationship between voluntary muscle strength and physical activity

Eligibility criteria: Inclusion criteria:

* chronic kidney disease patient with extrarenal replacement therapy by hemodialysis for at least 3 months
* stable clinical condition (absence of infection, stroke or acute decompensation)

Exclusion criteria:

* chronic kidney disease without extrarenal replacement therapy
* history of renal transplantation

Primary outcomes:
measure: Mortality at 2 years
timeFrame: 2 years
Secondary outcomes:
Other outcomes:
Locations:
city: Montpellier
country: France
facility: Uhmontpellier
Study officials:
affiliation: CHU Lapeyronie, Department of Biochemistry and Hormonology, Montpellier, FRANCE
name: Jean-Paul CRISTOL, Prof
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT01060852: Evaluation of the Media Detective Program for Elementary School-Aged Children to Prevention Substance Use
Official title: Randomized Controlled Trial Efficacy Study of a Media Literacy Education Substance Use Prevention Program for Elementary School-Aged Children
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Alcohol Drinking
Tobacco Smoking
Lead sponsor: Innovation Research & Training
Sponsor class: OTHER
First posted: 2010-02-02
Enrollment: 679
Sex: ALL
Minimum age (years): 7
Maximum age (years): 12
Standard ages: CHILD
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: PREVENTION

Brief summary: The purpose of this study was to determine whether a media literacy education program taught be teacher to late elementary school students (grades 3-5) positively affected students' critical thinking skills and substance use-related health outcomes.

Detailed description: Media Detective is a 10-lesson elementary school, substance abuse prevention program developed based upon the Message Interpretation Processing model designed to increase children's critical thinking skills about media messages and reduce intent to use tobacco and alcohol products. The purpose of this study was to conduct a short-term randomized controlled trial study to evaluate the effectiveness of Media Detective for achieving these goals.

Eligibility criteria: Inclusion Criteria:

* Must be able to read and write in English

Exclusion Criteria:

* None

Primary outcomes:
measure: Intent to alcohol or tobacco products
timeFrame: 2 weeks: pretest and posttest
Secondary outcomes:
measure: Understanding of the persuasive intent of advertising
timeFrame: 2 weeks: pretest and posttest
measure: Media deconstruction skills
timeFrame: 2 weeks: pretest and posttest
measure: Interest in alcohol-branded merchandise
timeFrame: 2 weeks: pretest and posttest
measure: Self-efficacy to refuse offers to use alcohol or tobacco products
timeFrame: 2 weeks: pretest and posttest
Other outcomes:
Locations:
city: Durham
country: United States
facility: innovation Research & Training
state: North Carolina
Study officials:
affiliation: Innovation Research & Training
name: Janis B Kupersmidt, PhD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT06281652: Cognitive Intervention With Go and Chess in Early and Subjective Cognitive Decline
Official title: Cognitive Intervention With Go and Chess in Early and Subjective Cognitive Decline
Study type: INTERVENTIONAL
Overall status: RECRUITING
Phase: NA
Conditions: Mild Cognitive Impairment
Subjective Cognitive Decline
Keywords: Subjective Cognitive Decline
Mild Cognitive Impairment
Cognitive enhancement
Board games
Lead sponsor: University of Milano Bicocca
Sponsor class: OTHER
First posted: 2024-02-28
Enrollment: 80
Sex: ALL
Minimum age (years): 55
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: OTHER

Brief summary: The goal of this clinical trial\]is to evaluate if learning to play traditional board games could improve cognition in subjects with mild cognitive impairment and subjective cognitive decline. The main questions it aims to answer are:

* Do Go and Chess improve cognition?
* Is a game better than the other? Is the effect of both games on cognition synergistic?
* Do Go and Chess improve quality of life?
* Do Go and Chess improve mood?
* Do Go and Chess improve lifestyle?

Participants will be randomized to one of four groups:

* Group intervention with Go, once a week, for 12 weeks
* Group intervention with Chess, once a week, for 12 weeks
* Group intervention with Go and Chess, twice a week, for 12 weeks
* Control group


Eligibility criteria: Inclusion Criteria:

* Diagnosis of mild cognitive impairment or subjective cognitive decline
* Willingness to participate in the board games classes
* Living within 20-minute driving distance from the center
* Signed informed consent

Exclusion Criteria:

* Prior knowledge of the the game rules (in case the subject knows one of the two, they can be randomized to the other one)
* Significant linguistic or sensory impairment (according to clinical judgment)
* Significant behavioral or psychiatric disturbances (according to clinical judgment)
* Significant medical comorbidities (according to clinical judgment)

Primary outcomes:
measure: General cognition
timeFrame: 12 weeks
Secondary outcomes:
measure: Digit Span Forward
timeFrame: 12 weeks
measure: Digit Span Backwards
timeFrame: 12 weeks
measure: Trail Making Test - part A
timeFrame: 12 weeks
measure: Trail Making Test - part B
timeFrame: 12 weeks
measure: Semantic fluency
timeFrame: 12 weeks
measure: Quality of life indicator
timeFrame: 12 weeks
measure: Depression
timeFrame: 12 weeks
measure: Lifestyle
timeFrame: 12 weeks
Other outcomes:
Locations:
city: Monza
country: Italy
facility: Fondazione IRCCS San Gerardo dei Tintori
state: Lombardia
Study officials:
affiliation: Fondazione IRCCS San Gerardo
name: Lucio Tremolizzo, MD, PhD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT06708052: Effects of Voodoo Flossing on Ankle in Participants with Limited Ankle Dorsiflexion
Official title: Effects of Voodoo Flossing on Ankle Range of Motion, Balance, Gait Ability in Participants with Limited Ankle Dorsiflexion
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Healthy Participants Study
Keywords: voodoo flossing
limited ankle dorsiflexion
Lead sponsor: Nambu University
Sponsor class: OTHER_GOV
Collaborators: name: Nambu University
First posted: 2024-11-27
Enrollment: 40
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Intervention model description: Ankle application in voodoo flossing and control group
Primary purpose: TREATMENT

Brief summary: In the case of normal walking patterns, the angle of plantarflexion (PF) at heel contact should be 0 to 5 degrees, the angle of dorsiflexion (DF) in the terminal stance should be 10 degrees, and the angle of PF should be 15-20 degrees when the heel off. A therapist can apply a voodoo flossing to enhance range of motion (ROM), pain control, jumping performance, strength, myofascial release, and recovery from fatigue. This study compared the immediate effects of voodoo flossing application on ankle ROM, balance, and gait ability in stroke patients. Outcome measures were ankle ROM, weight bearing lunge test (WBLT) performance, static balance (one leg test), dynamic balance(Y-balance test) and gait ability. Outcome measures were assessed at baseline and immediately after applying the voodoo flossing.

Detailed description: The voodoo flossing intervention used the standard voodoo flossing, wrapping a voodoo flossing (lime green Sanctband Comprefloss™, 2" × 3.5 m; PENTEL, Shah Alam, Malaysia) made of natural rubber tightly around the ankle on the affected side. It was started at the fifth metatarsal and wrapped horizontally around the metatarsals twice, in a figure eight to the medial malleolus, over the Achilles tendon and the lateral malleolus three times, and around the medial malleolus again, before being passed twice from the medial mal-leolus over the Achilles tendon to the lateral malleolus, forming an end knot. The participants were instructed to perform low-intensity active exercise involving ankle DF and plantar flexion for 2 minutes after applying the floss band. Then, the floss band was removed and the patient was asked to walk lightly on level ground for about 1 minute to allow reperfusion to normalize blood flow.

Eligibility criteria: Inclusion Criteria:

* less than 10° of dorsiflexion

Exclusion Criteria:

* lower extremity orthopedic problems
* unstable steps and balance
* visual impairments

Primary outcomes:
measure: Ankle range of motion
timeFrame: 1 year
measure: Weight-bearing lunge test
timeFrame: 1 year
measure: Static balance ability
timeFrame: 1 year
measure: dynamic balance ability
timeFrame: 1 year
measure: Gait ability
timeFrame: 1 year
Secondary outcomes:
Other outcomes:
Locations:
city: Gwangju
country: Korea, Republic of
facility: Nambu University
state: Gwangsan-gu
Study officials:
References:
Clinical trial NCT01580852: The Effects of Immersion in Dead Sea Water on Glucose Levels in Type 2 Diabetes Mellitus Patients
Official title: The Effects of Immersion in Dead Sea Water on Glucose Levels in Type 2 Diabetes Mellitus Patients
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Type 2 Diabetes Mellitus
Lead sponsor: Soroka University Medical Center
Sponsor class: OTHER
First posted: 2012-04-19
Enrollment: 35
Sex: ALL
Minimum age (years): 18
Maximum age (years): 65
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: BACKGROUND: Bathing in sweet or mineral water can induce significant physiological changes in several body systems including the endocrine system. To date, there have only been a small number of reports that balneology can reduce blood sugar Levels in patients with type 2 diabetes mellitus (DM\].

OBJECTIVE: To compare the effects of a immersion in sweet or mineral water on blood glucose levels in patients with type 2 DM.

METHODS: Forty patients with type 2 DM will immerse in either sweet or mineral water twice daily. In both cases the water will be warmed to a temperature of 35 degrees C and the bath continue for 20 minutes.


Eligibility criteria: Inclusion Criteria:

* Uncontrolled type 2 diabetes mellitus patients(HbA1c levels between 7.5-10)
* Ages 18-65
* Signed Informed Consent

Exclusion Criteria:

* Peripheral neuropathy
* Diabetic ulcers or damaged skin
* PVD
* Diabetes diagnosis for over 20 years
* Orthostatic Hypotension

Primary outcomes:
measure: Glucose Levels
timeFrame: participants will be followed for the duration of hotel stay, an expected average of 5 days
Secondary outcomes:
measure: HbA1c levels
timeFrame: three months afer intervention
Other outcomes:
Locations:
city: Beer Sheva
country: Israel
facility: Soroka University Medical Cetner
Study officials:
affiliation: Soroka University Medical Center
name: Idit Liberty, MD
role: PRINCIPAL_INVESTIGATOR
References: