Clinical trial NCT06292988: Predictive Factors for Medullary Thyroid Cancer Aggressiveness
Official title: Predective Factors for Tumor Aggressiveness in Medullary Thyroid Cancer
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Medullary Thyroid Cancer
Lead sponsor: Aristotle University Of Thessaloniki
Sponsor class: OTHER
First posted: 2024-03-05
Enrollment: 500
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: RETROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: All patients \>18 years old who underwent surgery for medullary thyroid cancer are enrolled in this study

Brief summary: This study is a retrospective study trying to find the predictive factors for medullary thyroid aggressiveness in terms of tumor metastasis and patients' survival.

Detailed description: This study is a retrospective study trying to find the predictive factors for medullary thyroid aggressiveness in terms of tumor metastasis and patients' survival. The predictive factors included in this study are central and lateral compartment lymph node metastases as well as distant metastasis up to 1 year postoperatively, while biochemical predictors (meaning ratios such as lymphocyte to monocyte ratio etc and CEA and calcitonin drop levels) and histological predictors (such as nuclear atypia, amyloid, immunohistochemistry, desmoplasia) are included as secondary outcomes. In this study , patients \>18 years old that underwent surgery for medullary thyroid cancer (total thyroidectomy, completion thyroidectomy) +/- central/lateral neck dissection) will be enrolled.

Eligibility criteria: Inclusion Criteria:

* Patients who underwent thyroidectomy for medullary thyroid cancer (total thyroidectomy, completion thyroidectomy) +/- central/lateral neck dissection

Exclusion Criteria:

* Age \< 18 years

Primary outcomes:
measure: Central lymph node metastasis
timeFrame: Number of lymph node Metastasis found in preoperative imaging studies or up to 1 year postoperatively
measure: Lateral lymph node metastasis
timeFrame: Number of lymph node Metastasis found in preoperative imaging studies or up to 1 year postoperatively
measure: Distant metastasis
timeFrame: Number of distant Metastasis found in preoperative imaging studies or up to 1 year postoperatively
Secondary outcomes:
measure: Nuclear atypia as histological predictor of aggressiveness
timeFrame: The pathology report is held immediately after surgery
measure: Amyloid as histological predictor of aggressiveness
timeFrame: The pathology report is held immediately after surgery
measure: Immunohistochemistry as histological predictor of aggressiveness
timeFrame: The pathology report is held immediately after surgery
measure: Desmoplasia as histological predictor of aggressiveness
timeFrame: The pathology report is held immediately after surgery
measure: CEA as Biochemical predictor of aggressiveness
timeFrame: pre and postoperative laboratory exams up to 1 year postoperatively
measure: Calcitonin as Biochemical predictor of aggressiveness
timeFrame: pre and postoperative laboratory exams up to 1 year postoperatively
measure: White blood cell as Biochemical predictor of aggressiveness
timeFrame: pre and postoperative laboratory exams up to 1 year postoperatively
measure: Platelet count as Biochemical predictor of aggressiveness
timeFrame: pre and postoperative laboratory exams up to 1 year postoperatively
measure: CEA drop as Biochemical cure marker
timeFrame: up to 1 year postoperatively
measure: Calcitonin drop as Biochemical cure marker
timeFrame: up to 1 year postoperatively
Other outcomes:
Locations:
city: Oregon City
country: United States
facility: Oregon Health & Science University, Oregon
state: Oregon
city: Salzburg
country: Austria
facility: Department of Surgery, Saint John of God Hospital, Salzburg, Austria
city: Bruxelles
country: Belgium
facility: Saint Luc, University Clouvain, Belgium
city: Santa Cruz Do Sul
country: Brazil
facility: Head and Neck Surgery Department, Hospital Ana Nery, Santa Cruz do Sul, Brazil
city: Sofia
country: Bulgaria
facility: University Clinic of Surgery, University Hospital "Lozenec"
city: Hong Kong
country: China
facility: Chinese University of Hong Kong
city: Manizales
country: Colombia
facility: Head and Neck Department Oncologos del Occidente, Universidad de Caldas, Manizales, Colombia
city: Zagreb
country: Croatia
facility: the University Hospital Center Sestre milosrdnice, Zagreb, Croatia, Department of Otorhinolaryngology and Head and Neck Surgery
city: Brest
country: France
facility: Head and Neck Surgery, Brest University Hospital, Brest, France
city: Poitiers
country: France
facility: The University Hospital of Poitiers, France
city: Athens
country: Greece
facility: Thyroid Surgery Clinic IKE, Athens, Greece
city: Larissa
country: Greece
facility: ENT Department University Hospital of Larissa
city: Patra
country: Greece
facility: Department of Surgery, General University Hospital of Patras
city: Thessaloníki
country: Greece
facility: Aristotle University of Thessaloniki
city: Thessaloníki
country: Greece
facility: Gennimatas General Hospital
city: Bhubaneswar
country: India
facility: Department of ENT-Head and Neck Surgery, All India Institute of Medical Sciences, Bhubaneswar
city: Coimbatore
country: India
facility: KMCH and KMCH Comprehensive Cancer Center
city: Madurai
country: India
facility: Department of Endocrine and Breast Surgery at Sanjay Gandhi Post Graduate Institute of Medical Sciences
city: New Delhi
country: India
facility: Department of Surgery, Maulana Azad Medical College & Lok Nayak Hospital
city: Vijayawada
country: India
facility: Endocrine and Metabolic Surgery, Bhargav Endocrine Hospital, Vijayawada, India
city: Erbil
country: Iraq
facility: University of Sulaimani | UNIVSUL ,Department of Surgery, Kurdistan
city: Domodossola
country: Italy
facility: ASL VCO - San Biagio Hospital - Domodossola (VB) - Italy
city: Genoa
country: Italy
facility: Dipartimento di Scienze Chirurgiche (DISC), University of Genoa, Italy
city: Milan
country: Italy
facility: Asst Santi Paolo e Carlo - Ospedale Polo Universitario San Paolo, Milan, Italy
city: Roma
country: Italy
facility: UOC Chirurgia Endocrina e Metabolica, Fondazione Policlinico Universitario A Gemelli IRCCS
city: Trieste
country: Italy
facility: Department of Medical and Surgical Sciences, University of Trieste, Cattinara Teaching Hospital, Trieste, Italy
city: Verona
country: Italy
facility: Department of Surgery and Oncology, Endocrine Surgery Unit, Verona University Hospital
city: Zarqa
country: Jordan
facility: Hashemite University of Zarqa
city: Marrakech
country: Morocco
facility: Hepatobiliairy and endocrine surgery, Ibn Sina Hospital, Medical School of Medecine Rabat, Mohamed Vth University of Rabat Morocco
city: Gdańsk
country: Poland
facility: Division of General, Endocrine and Transplant Surgery, Medical University of Gdańsk
city: Belgrad
country: Serbia
facility: Surgical Oncology Clinic, Institute for Oncology and Radiology of Serbia, Medical School, University of Belgrade
city: Bratislava
country: Slovakia
facility: Comenius University in Bratislava, Department of Paediatric Surgery, National Institute of Children's Diseases
city: Bratislava
country: Slovakia
facility: Department of oncological surgery, St. Elisabeth cancer Institute
city: Barcelona
country: Spain
facility: Hospital Clinic (Barcelona, Spain)
city: Córdoba
country: Spain
facility: Universitaria de Cordoba
city: Málaga
country: Spain
facility: Hospital Regional de Málaga
city: Vigo
country: Spain
facility: Department of General and Digestive Surgery, Division of Endocrine Surgery, Complexo Hospitalario Universitario de Vigo, Vigo, Spain
city: Bern
country: Switzerland
facility: Bern University Hospital
city: Geneva
country: Switzerland
facility: Geneva University Hospital
city: Bangkok
country: Thailand
facility: Division of Endocrinology and Metabolism Department of Medicine Faculty of Medicine Ramathibodi Hospital Mahidol University Bangkok, Thailand
city: Ankara
country: Turkey
facility: Ankara University Faculty of Medicine, Department of Endocrine Surgery
city: Istanbul
country: Turkey
facility: Acibadem MAA University
city: Istanbul
country: Turkey
facility: Cerrahpasa medical faculty endocrine surgery department
city: Istanbul
country: Turkey
facility: Department of Endocrin Pathology Unit, University of Health Sciences, Faculty of Medicine, Bakırköy Dr Sadi Konuk Training and Research Hospital, Istanbul, Turkey
city: Kyiv
country: Ukraine
facility: Endocrine surgeon-consultant, International medical center "CITIDOCTOR"
city: Việt Trì
country: Vietnam
facility: Department of Radiology, Thien Hanh Hospital, Buon Ma Thuot, Vietnam
Study officials:
affiliation: 1st Propedeutic Department of Surgery, AHEPA University Hospital of Thessaloniki, Greece
name: Theodossis Papavramidis, Prof
role: PRINCIPAL_INVESTIGATOR
References: