Clinical trial NCT04773444: Eccentric Cycling Exercise on Hemodynamic and Hemorheologic Properties
Official title: Effects of Eccentric and Concentric Cycling Exercise Regimens on Hemodynamic and Hemorheologic Properties in Sedentary Male
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Eccentric Exercise Training
Keywords: eccentric cycling
erythrocyte
hemodynamic
Lead sponsor: Chang Gung Memorial Hospital
Sponsor class: OTHER
First posted: 2021-02-26
Enrollment: 60
Sex: MALE
Minimum age (years): 20
Maximum age (years): 30
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The effects of an eccentric endurance training on central and peripheral hemodynamic adaptations and erythrocyte rheology during maximal exercise remained to be unexplored. The current study examined the contribution of rheological functions and/or hemodynamic adaptation to changes in oxygen consumption (VO2) following the matched-power output eccentric (ECT) or concentric cycling training (CCT).

Method: A total of 39 sedentary males were randomly assigned into either CCT (n=13) or ECT (n=13) for 30 min a day, 5 days a week for 6 weeks at 60% of maximal workload or to a CTL (control group, n = 13). A graded exercise test (GXT) was performed before and after the intervention. Central and microvascular adaptations were evaluated using thoracic impedance and near-infrared spectroscopy (NIRS), respectively. Rheological characteristics was determined by an ektacytometer.

Detailed description: Endurance training is a well known strategy for improving fitness capacity. However, some populations are intolerance to complete the usual exercise training program, such as chronic heart or pulmonary disease or the elderly. Therefore, ECT is a candidate training strategy for those individuals.

Erythrocytes deformability is significantly related to the blood perfusion in microcirculation. The impaired erythrocyte-related rheology further lead to reduced aerobic capacity by our research team. Therefore, the lower energy consumed in ECT may avoid the oxidative stress. To now, less studies have demonstrated whether ECT influences peripheral hemodynamics by erythrocyte rheology and the blood flow from the central effect.

The investigators aimed to investigate the effects of CCT and ECT on oxygen consumption response explained by changes in local blood perfusion, blood cell rheology, or central function to attempt developing its application in rehabilitation.

Eligibility criteria: Inclusion Criteria:

* in sedentary lifestyle, who were nonsmokers, nonusers of medications/vitamins, and free of any cardiopulmonary/hematological risks

Exclusion Criteria:

* regular exercise habits (i.e., exercise frequency once per week, duration \>20 min).

Primary outcomes:
measure: Central and peripheral hemodynamics
timeFrame: 12 weeks
Secondary outcomes:
measure: Cardiopulmonary fitness
timeFrame: 12 weeks
measure: Erythrocyte rheological characteristics
timeFrame: 12 weeks
Other outcomes:
Locations:
city: Taoyuan
country: Taiwan
facility: Chang Gung University
Study officials:
affiliation: Chang Gung Memorial Hospital
name: Jong-Shyan Wang, PhD
role: PRINCIPAL_INVESTIGATOR
References:
citation: Hoppeler H. Moderate Load Eccentric Exercise; A Distinct Novel Training Modality. Front Physiol. 2016 Nov 16;7:483. doi: 10.3389/fphys.2016.00483. eCollection 2016.
citation: Haynes A, Linden MD, Chasland LC, Nosaka K, Maiorana A, Dawson EA, Dembo LH, Naylor LH, Green DJ. Acute impact of conventional and eccentric cycling on platelet and vascular function in patients with chronic heart failure. J Appl Physiol (1985). 2017 Jun 1;122(6):1418-1424. doi: 10.1152/japplphysiol.01057.2016. Epub 2017 Mar 16.
citation: Lindstedt SL, LaStayo PC, Reich TE. When active muscles lengthen: properties and consequences of eccentric contractions. News Physiol Sci. 2001 Dec;16:256-61. doi: 10.1152/physiologyonline.2001.16.6.256. No abstract available.
citation: LaStayo PC, Ewy GA, Pierotti DD, Johns RK, Lindstedt S. The positive effects of negative work: increased muscle strength and decreased fall risk in a frail elderly population. J Gerontol A Biol Sci Med Sci. 2003 May;58(5):M419-24. doi: 10.1093/gerona/58.5.m419.