Clinical trial NCT01532388: Randomized Controlled Trial of eScreen for Problematic Drug Use
Official title: Randomized Controlled Trial of eScreen for Problematic Drug Use
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Problematic AOD Use
Keywords: Randomized Controlled Trial
Alcohol
Drugs
Internet
Screening
Brief intervention
Lead sponsor: Karolinska Institutet
Sponsor class: OTHER
First posted: 2012-02-14
Enrollment: 202
Sex: ALL
Minimum age (years): 15
Maximum age (years): 99
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: Objectives: This study compared the efficacy of eScreen in a two-armed randomized controlled design, measuring outcomes in terms of changes in problematic drug use up to one year after study recruitment. The eScreen brief Internet intervention for problematic alcohol and drug use offers self-screening, in-depth self-reporting, personalized feedback and treatment recommendations as well as an electronic diary. Progress over time is shown in diagrams detailing consumption levels.

Method: Participants with only problematic drug use according to the Drug Use Disorders Identification Test (DUDIT),(DUDIT \>0 for both men and women) or both problematic alcohol use according to the Alcohol Use Disorders Identification Test (AUDIT), (AUDIT \>7 for men and AUDIT \>5 for women) and drug use were randomized to T1 (n=101) or the control group (n=101). Outcomes on alcohol and/or drug use as well as health-related symptoms were assessed after 3, 6 and 12 months.

Hypotheses that were tested in this study are 1) that both groups would reduce their drug consumption and drug-related problems at follow-ups compared to the baseline level and 2) that participants in the eScreen group would reduce their drug consumption and drug-related problems to a higher extent than participants in the control group (no intervention) at follow-ups.

Detailed description: Background: The aim of this study is to investigate the effects of an Internet-based screening and brief intervention (SBI) site for problematic alcohol and drug use among illicit drug users.

Method: Individuals searching for information about alcohol or drugs online who scored over 0 on the Drug Use Disorders Identiﬁcation Test (DUDIT) and were 15 years or older were recruited for this trial and randomized into one group receiving Internet-based screening and brief intervention via eScreen.se(n = 101) or one assessment-only control group (n = 101). Both groups were screened at baseline and followed up at 3 and 6 months. The primary outcome measure was the DUDIT-C score and secondary outcome measures were DUDIT, AUDIT-C (Alcohol Use Disorders Identiﬁcation Test-C) and AUDIT scores.Additional outcomes included the proportion of drug abstainers and those who made a clinically signiﬁcant change in their alcohol and drug use. Four statistical models of analysis were used to conservatively assess results.

Eligibility criteria: Inclusion Criteria:

* DUDIT \>0

Exclusion Criteria:

* DUDIT = 0

Primary outcomes:
measure: Drug Use Disorders Identification Test-Consumption (DUDIT-C)
timeFrame: 3 months
Secondary outcomes:
measure: Drug Use Disorders Identification Test (DUDIT)
timeFrame: 3 months
measure: Alcohol Use Disorders Identification Test - Consumption (AUDIT-C)
timeFrame: 3 months
measure: Alcohol Use Disorders Identification Test - AUDIT
timeFrame: 3 months
measure: Drug Use Disorders Identification Test-Consumption (DUDIT-C)
timeFrame: 6 months
measure: Drug Use Disorders Identification Test (DUDIT)
timeFrame: 6 months
measure: Alcohol Use Disorders Identification Test-Consumption (AUDIT-C)
timeFrame: 6 months
measure: Alcohol Use Disorders Identification Test (AUDIT)
timeFrame: 6 months
measure: Drug Use Disorders Identification Test-Consumption (DUDIT-C)
timeFrame: 12 months
measure: Drug Use Disorders Identification Test (DUDIT)
timeFrame: 12 months
measure: Alcohol Use Disorders Identification Test-Consumption (AUDIT-C)
timeFrame: 12 months
measure: Alcohol Use Disorders Identification Test (AUDIT)
timeFrame: 12 months
Other outcomes:
Locations:
city: Stockholm
country: Sweden
facility: Karolinska institutet, Department of Clinical Neurosciene
Study officials:
affiliation: Karolinska Institutet
name: Anne H Berman, PhD
role: PRINCIPAL_INVESTIGATOR
References:
citation: Sinadinovic K, Berman AH, Hasson D, Wennberg P. Internet-based assessment and self-monitoring of problematic alcohol and drug use. Addict Behav. 2010 May;35(5):464-70. doi: 10.1016/j.addbeh.2009.12.021. Epub 2010 Jan 4.
citation: Sinadinovic K, Wennberg P, Berman AH. Population screening of risky alcohol and drug use via Internet and Interactive Voice Response (IVR): a feasibility and psychometric study in a random sample. Drug Alcohol Depend. 2011 Mar 1;114(1):55-60. doi: 10.1016/j.drugalcdep.2010.09.004. Epub 2010 Oct 27.
citation: Sinadinovic K, Wennberg P, Berman AH. Targeting problematic users of illicit drugs with Internet-based screening and brief intervention: a randomized controlled trial. Drug Alcohol Depend. 2012 Nov 1;126(1-2):42-50. doi: 10.1016/j.drugalcdep.2012.04.016. Epub 2012 May 20.
citation: Sinadinovic K, Wennberg P, Berman AH. Internet-based screening and brief intervention for illicit drug users: a randomized controlled trial with 12-month follow-up. J Stud Alcohol Drugs. 2014 Mar;75(2):313-8. doi: 10.15288/jsad.2014.75.313.