Clinical trial NCT01528748: Clinical Trial of CBASP for Individuals With Co-occurring Chronic Depression and Alcohol Dependence
Official title: Clinical Trial of CBASP for Individuals With Co-occurring Chronic Depression and Alcohol Dependence
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Depressive Disorder
Major Depressive Disorder
Dysthymic Disorder
Alcohol-Related Disorders
Alcoholism
Lead sponsor: University of Virginia
Sponsor class: OTHER
First posted: 2012-02-08
Enrollment: 8
Sex: ALL
Minimum age (years): 21
Maximum age (years): 65
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Participants will be recruited via a community sample.

Brief summary: This study examines the effectiveness of Cognitive Behavioral Analysis System of Psychotherapy (CBASP) in reducing both alcohol consumption and depressive symptoms in adults who are chronically depressed and alcohol dependent.

Detailed description: This study examines the effectiveness of Cognitive Behavioral Analysis System of Psychotherapy (CBASP) in reducing both alcohol consumption and depressive symptoms in adults who are chronically depressed and alcohol dependent. Participants will receive a 20-session course of CBASP psychotherapy over a period of 21 weeks and will be assessed for severity of pretreatment psychological abuse and trauma as well as pre and posttreatment interpersonal functioning. Two primary hypotheses are to be tested: 1) demonstrate that CBASP is effective in reducing depressive symptoms (Hamilton Rating Scale for Depression-24 ratings) and alcohol consumption (drinks per drinking day) in this chronically depressed alcohol dependent cohort when posttreatment ratings are compared to pretreatment levels; and 2) demonstrate that acquisition of feeling safe with the therapist and acquisition of the ability to perceive the interpersonal consequences of one's behavior will significantly increase from pre to posttreatment levels and will be associated with reductions in drinking and depressive symptoms.

Eligibility criteria: Inclusion Criteria:

* Clinical diagnosis of a current major depressive disorder (e.g., Major Depression, Dysthymic Disorder) for a minimum of two years
* Clinical diagnosis of alcohol dependence during the last thirty days
* Interest in changing one's drinking and alleviating depressive symptoms

Exclusion Criteria:

* Please call study site for additional information

Primary outcomes:
measure: Depression Rating
timeFrame: Baseline and 20 weeks
measure: Drinking behavior
timeFrame: Baseline and 20 weeks
Secondary outcomes:
Other outcomes:
Locations:
city: Charlottesville
country: United States
facility: University of Virginia Center for Addiction Research & Education (UVa CARE)
state: Virginia
Study officials:
affiliation: University of Virginia, School of Medicine, Department of Psychiatry & Neurobehavioral Sciences
name: Jennifer K. Penberthy, Ph.D.
role: PRINCIPAL_INVESTIGATOR
References:
citation: McCullough JP Jr. Treatment for chronic depression using Cognitive Behavioral Analysis System of Psychotherapy (CBASP). J Clin Psychol. 2003 Aug;59(8):833-46. doi: 10.1002/jclp.10176.
citation: McCullough, Jr., JP. (2001). Skills Training Manual for Diagnosis and Treating Chronic Depression: Cognitive Behavioral Analysis System of Psychotherapy (CBASP). New York: Guilford Press.