Clinical trial NCT02930356: Effect of Tooth Cleaning in Smokers and Non Smokers With Gum Disease.
Official title: Effects of Nonsurgical Periodontal Therapy on Plasma Hepatocyte Growth Factor Levels in Smokers and Non Smokers With Chronic Periodontitis
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Chronic Periodontitis
Lead sponsor: Panineeya Mahavidyalaya Institute of Dental Sciences & Research Centre
Sponsor class: OTHER
First posted: 2016-10-12
Enrollment: 40
Sex: ALL
Minimum age (years): 20
Maximum age (years): 60
Standard ages: ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: This study is intended to measure hepatocyte growth factor levels in smokers and non smokers with periodontitis before and after non surgical periodontal therapy.

Detailed description: The study was randomised prospective,interventional clinical trial. The sample size for the study was 40 individuals aged between 20 to 60 years,equally divided into two groups.

Group l - smokers with chronic periodontitis (test) group. Group ll - non smokers with chronic periodontitis (controls)

At baseline both the groups were analysed for clinical and biochemical parameters and underwent non surgical periodontal therapy( scaling and root planning). All parameters were reassesed after 3 months.

A total of 40 patients( 20 somkers and 20 non smokers) from the outpatient wing of department of periodontics, Panineeya mahavidyalaya institute of dental sciences and research centre diagnosed with chronic periodontitis and willing to participate in the study.

Clicical parameters included gingival index and periodontal index. Biochmeical parameters included plasma hepatocyte growth factor.

Eligibility criteria: Inclusion Criteria:

* probing depth \>4mm
* clinical attachment loss\>2mm

Exclusion Criteria:

* patients younger than 20 years and greater than 60 years
* presence of any chronic conditions like diabetes,infections
* antibiotic therapy received preceeding 3 months
* former smokers who had quit the habit of smoking
* patients who already underwent periodontal therapy

Primary outcomes:
measure: Primary outcome of the study was to measure plasma heaptocyte growth factor level
timeFrame: baseline, 3 months
Secondary outcomes:
measure: gingival index
timeFrame: baseline and 3 months
measure: periodontal index
timeFrame: baseline and 3 months
Other outcomes:
Locations:
Study officials:
affiliation: Panineeya Mahavidyalaya Institute of Dental Sciences and Research Centre
name: Dr.Veerendranath R Panthula, MDS
role: STUDY_DIRECTOR
References:
citation: Anil S, Vellappally S, Preethanath RS, Mokeem SA, AlMoharib HS, Patil S, Chalisserry EP, Al Kheraif AA. Hepatocyte growth factor levels in the saliva and gingival crevicular fluid in smokers with periodontitis. Dis Markers. 2014;2014:146974. doi: 10.1155/2014/146974. Epub 2014 Oct 15.
citation: Rudrakshi C, Srinivas N, Mehta DS. A comparative evaluation of hepatocyte growth factor levels in gingival crevicular fluid and saliva and its correlation with clinical parameters in patients with and without chronic periodontitis: A clinico-biochemical study. J Indian Soc Periodontol. 2011 Apr;15(2):147-51. doi: 10.4103/0972-124X.84384.