louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT01442285: The Mental Health and Dynamic Referral for Oncology Protocol (MHADRO)
Official title: The Mental Health and Dynamic Referral for Oncology Protocol (MHADRO)
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Cancer
Distress
Lead sponsor: University of Massachusetts, Worcester
Sponsor class: OTHER
Collaborators: name: National Institute of Mental Health (NIMH)
name: Polaris Health Directions
First posted: 2011-09-28
Enrollment: 1000
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: HEALTH_SERVICES_RESEARCH

Brief summary: The purpose of this study is to understand more about meeting the psychosocial needs of people who have cancer.

Detailed description: The investigators are interested in the feasibility of using computer assisted screening and assessment to meet the psychosocial needs of people with cancer. The investigators are studying two different interventions. Both groups will receive health information, referral information, and resources. One group will also receive tailored feedback reports.

Eligibility criteria: Inclusion Criteria:

* cancer diagnosis

Primary outcomes:
measure: Decrease in psychological stress
timeFrame: 12 months
Secondary outcomes:
measure: Reduced distress
timeFrame: 12 months
Other outcomes:
Locations:
city: Worcester
country: United States
facility: University of Massachusetts Medical School, UMass Memorial
state: Massachusetts
Study officials:
affiliation: University of Massachusetts, Worcester
name: Edwin Boudreaux, PhD
role: PRINCIPAL_INVESTIGATOR
References:
citation: O'Hea E, Kroll-Desrosiers A, Cutillo AS, Michalak HR, Barton BA, Harralson T, Carmack C, McMahon C, Boudreaux ED. Impact of the mental health and dynamic referral for oncology (MHADRO) program on oncology patient outcomes, health care utilization, and health provider behaviors: A multi-site randomized control trial. Patient Educ Couns. 2020 Mar;103(3):607-616. doi: 10.1016/j.pec.2019.10.006. Epub 2019 Nov 5.
citation: O'Hea EL, Monahan BR, Cutillo A, Person SD, Grissom G, Boudreaux ED. Predictors of psychological distress and interest in mental health services in individuals with cancer. J Health Psychol. 2016 Jun;21(6):1145-56. doi: 10.1177/1359105314547752. Epub 2014 Sep 9.
Clinical trial NCT02301585: Optimization of Fluid Therapy in Sepsis by a Passive Leg Raising Test
Official title: Optimization of Fluid Therapy by a Passive Leg Raising Test in Patients With Septic Shock in the ICU
Study type: INTERVENTIONAL
Overall status: TERMINATED
Phase: NA
Conditions: Shock, Septic
Keywords: shock, septic
hemodynamics
algorithms
Lead sponsor: Karolinska Institutet
Sponsor class: OTHER
Collaborators: name: Region Stockholm
name: Svenska militärläkarföreningen
First posted: 2014-11-26
Enrollment: 34
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: A randomized controlled clinical trial to evaluate whether a passive leg raising test to guide fluid therapy of patients with septic shock can reduce fluid balance and weight gain. Patients will be treated according to an algorithm in which the indexed stroke volume (stroke volume related to body surface area) and mean arterial pressure will guide the timing and amount of fluid and the use of inotropic and vasoactive support. Patients will be randomized to either an intervention group in which a passive leg raising test will be made prior to any decision for fluid administration or to a control group where this test is not performed and fluid administration is carried out according to standard of care at the department.

Hypothesis: A passive leg raising test, will reduce weight gain by day 3 by 30%.


Eligibility criteria: Inclusion Criteria:

All patients \>18 years admitted to the ICU diagnosed with circulatory shock due to suspected sepsis or pancreatitis. Circulatory shock is defined as MAP\<70 mm Hg or need for norepinephrine despite resuscitation with ≥30 ml/kg of crystalloid fluids.

Exclusion Criteria:

\> 12 hours have passed after onset of shock. The patient has contraindications for an arterial femoral/axillary line. Elevated ICP. Patients who have had a femoral amputation. Elevated intraabdominal pressure\>20 cm H2O.

Suspension criteria: The patient has developed pulmonary oedema during PLR test. Life threatening bleeding.

Serious adverse events:

Trombosis in arteria femoralis. Death during the study period.

Primary outcomes:
measure: weight gain
timeFrame: 3 days
Secondary outcomes:
measure: ICU length of stay
timeFrame: measured within 90 days after inclusion
measure: Cumulative fluid balance study day 1,2,3
timeFrame: Study day 1,2,3
measure: 30 day mortality
timeFrame: 30 days from inclusion in the study
measure: Organ support during ICU stay
timeFrame: ICU-stay
measure: ICU discharge status
timeFrame: End of ICU stay
Other outcomes:
Locations:
city: Stockholm
country: Sweden
facility: Karolinska Institutet Södersjukhuset
Study officials:
affiliation: Karolinska Institutet
name: Christer Svensen, Prof
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT03432585: Parent/Caregiver Conference Attendance Feasibility
Official title: Parent/Caregiver Conference Attendance Feasibility
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Health Knowledge, Attitudes, Practice
Keywords: feasibility
attendance
conference
Lead sponsor: University of Florida
Sponsor class: OTHER
Collaborators: name: American Society for Nutrition
First posted: 2018-02-14
Enrollment: 84
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Applicants for the Family Support Grant to the American Society for Nutrition annual conference that takes place in June 2018

Brief summary: This study will assess and evaluate conference attendance feasibility and will gather feedback about preferences and barriers to attendance at the American Society for Nutrition annual conference.

Detailed description: This study will use a survey provided on the American Society for Nutrition Family Support Grant application webpage for those who are registering to attend the American Society for Nutrition annual meeting and who are applying for this particular grant. The survey will take about 10 minutes to complete and will provide detailed information for assessment and evaluation of conference attendance feasibility and will also provide feedback about preferences and barriers related to attendance and this annual meeting.

Eligibility criteria: Inclusion Criteria:

* Must be an applicant for the Family Support Grant to the American Society for Nutrition annual conference that takes place in June 2018

Exclusion Criteria:

-

Primary outcomes:
measure: Participant likelihood of attendance to the American Society for Nutrition annual meeting if provided with a family support grant
timeFrame: 20 minutes to complete survey
Secondary outcomes:
measure: Grant option most likely to be used by participants
timeFrame: 20 minutes to complete survey
measure: Participants' opinion of greatest value of a family support grant should it be provided
timeFrame: 20 minutes to complete survey
measure: Participants' greatest barrier to attending the American Society for Nutrition annual meeting
timeFrame: 20 minutes to complete survey
measure: Most significant factor influencing the participant's decision to attend the American Society for Nutrition annual meeting
timeFrame: 20 minutes to complete survey
Other outcomes:
Locations:
city: Gainesville
country: United States
facility: University of Florida
state: Florida
Study officials:
affiliation: University of Florida
name: Michelle Cardel, PhD, RD
role: PRINCIPAL_INVESTIGATOR
References:
citation: Cardel MI, Loop MS, Brown AW, Bohan Brown MM, Newsome F, Scott L, Lemas DJ, Krukowski RA. Implementation of a Family Support Grant to Subsidize Caregiving Needs and Support Attendance at American Society for Nutrition's Annual Professional Scientific Conference. Curr Dev Nutr. 2022 Jun 23;6(6):nzac076. doi: 10.1093/cdn/nzac076. eCollection 2022 Jun.
Clinical trial NCT06098885: The Effect of Different Treatment Modalities of Class II Malocclusion on Upper Third Molars.
Official title: The Effect of Different Treatment Modalities of Class II Malocclusion on Upper Third Molars: A Retrospective Longitudinal Study
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Third Molar Impaction
Keywords: distalization
premolar extraction
upper third molar
impaction of third molar
Lead sponsor: Cairo University
Sponsor class: OTHER
First posted: 2023-10-25
Enrollment: 46
Sex: ALL
Minimum age (years): 16
Maximum age (years): 18
Standard ages: CHILD
ADULT
Accepts healthy volunteers: yes
Observational model: CASE_CONTROL
Time perspective: RETROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: • Egyptian Adolescent males and females (16 -18 years)

Brief summary: What is the effect of the different treatment modalities (distalization versus upper premolar extraction) of class II malocclusion on the position, inclination and incidence of impaction of the upper third molars?

Detailed description: What is the effect of the different treatment modalities (distalization versus upper premolar extraction) of class II malocclusion on the position, inclination and incidence of impaction of the upper third molars? Pico P: Adolescent patients with class II malocclusion having bilateral developing upper third molars.

I: bilateral upper first premolar extraction orthodontic treatment with moderate anchorage.

C: distalization orthodontic treatment. O: Primary: angulation of the maxillary third molars.

Eligibility criteria: Inclusion Criteria:

* Adolescent males and females (16 -18 years) with Bilaterally developing maxillary third molars. Not more than two thirds of the root development of the third molars had taken place.
* Class II malocclusion cases that were treated by 1) maxillary premolar extraction with a moderate anchorage requirement and achieved full unit class II molar relationship or 2) Distalization treatment plan and class I molar relationship was achieved.
* Patients with high-quality pre- and post-treatment radiographs.
* Normal or increased vertical dimension.

Exclusion Criteria:

* Maxillary Premolar extraction cases requiring maximum anchorage preparation.
* Low vertical dimension.
* Patients without dentofacial deformities, severe facial asymmetries, microdontia or hypodontia.

Primary outcomes:
measure: The angulation of the maxillary third molars.
timeFrame: up to 24 weeks.
Secondary outcomes:
measure: The vertical position of the third molars
timeFrame: up to 24 weeks
measure: The mineralization status of the third molars
timeFrame: up to 24 weeks
Other outcomes:
Locations:
city: Cairo
country: Egypt
facility: Amira Aboalnaga
Study officials:
References:
Clinical trial NCT01630785: Neurophysiological Intraoperative or Epilepsy Monitoring
Official title: Retrospective Data Analysis of Neurophysiological Data for Intraoperative or Epilepsy Monitoring
Study type: OBSERVATIONAL
Overall status: ENROLLING_BY_INVITATION
Conditions: Patients Operated on at the Neurosurgery Department
Lead sponsor: University of Zurich
Sponsor class: OTHER
First posted: 2012-06-28
Enrollment: 5000
Sex: ALL
Minimum age (years): 0
Maximum age (years): 100
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: CASE_CONTROL
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: All patients whose surgery involved intraoperative neurophysiological monitoring

Brief summary: The investigators record the outcome of patients whose surgery involved intraoperative neurophysiological monitoring

* Trial with surgical intervention


Eligibility criteria: Inclusion criteria: Patients whose surgery involved intraoperative neurophysiological monitoring

Primary outcomes:
measure: oncological outcome
timeFrame: 5 years
measure: neurological outcome
timeFrame: 1 year
measure: seizure outcome
timeFrame: 1 year
Secondary outcomes:
Other outcomes:
Locations:
city: Zurich
country: Switzerland
facility: University Hospital Zurich, Neurosurgery
state: ZH
Study officials:
affiliation: University Hospital Zurich, Division of Neurosurgery
name: Johannes Sarnthein, Prof Dr
role: PRINCIPAL_INVESTIGATOR
affiliation: University Hospital Zurich, Division of Neurosurgery
name: Oliver Bozinov, PD Dr
role: PRINCIPAL_INVESTIGATOR
affiliation: University Hospital Zurich, Division of Neurosurgery
name: Niklaus Krayenbühl, Prof Dr
role: PRINCIPAL_INVESTIGATOR
affiliation: University Hospital Zurich, Division of Neurosurgery
name: Luca Regli, Prof Dr
role: PRINCIPAL_INVESTIGATOR
References:
citation: Yang Y, Neidert MC, Velz J, Kalin V, Sarnthein J, Regli L, Bozinov O. Mapping and Monitoring of the Corticospinal Tract by Direct Brainstem Stimulation. Neurosurgery. 2022 Sep 1;91(3):496-504. doi: 10.1227/neu.0000000000002065. Epub 2022 Jul 14.
Clinical trial NCT03227185: Supporting Episodic Memory With Transcranial Direct Current Stimulation in Healthy Controls and Dementia Patients
Official title: Supporting Episodic Memory With Transcranial Direct Current Stimulation in Healthy Young and Elderly Participants as Well as in Individuals With Memory Impairment
Study type: INTERVENTIONAL
Overall status: TERMINATED
Phase: NA
Conditions: Healthy
Mild Cognitive Impairment
Alzheimer Disease
Lead sponsor: University of Bern
Sponsor class: OTHER
First posted: 2017-07-24
Enrollment: 55
Sex: ALL
Minimum age (years): 20
Maximum age (years): 85
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: CROSSOVER
Intervention model description: Participants will be randomly assigned to two possible sequences of stimulation conditions. Group 1 will receive real tDCS stimulation to the left dlPFC during encoding on the first day and sham stimulation on the second day, and group 2 will receive sham stimulation during encoding on the first day and real tDCS on the second day. The participants will be randomized with equal probability to each of the two groups, using block randomization..
Primary purpose: BASIC_SCIENCE

Brief summary: Previous studies showed that anodal tDCS applied over the dorsolateral prefrontal cortex (DLPFC) improved episodic memory performance, indicating a possible use as an intervention for patients suffering from memory impairments. At the same time, only scant evidence (provided by functional magnetic resonance imaging (fMRI) and magnetic resonance spectroscopy (MRS)) exists regarding the underlying mechanisms, thus hindering a more targeted application.

The present study aims at establishing a connection between the stimulation-induced change in episodic memory performance on the behavioural level and neurophysiological parameters. TDCS effects and the underlying mechanisms will be compared between different study conditions, receiving either real anodal tDCS or sham stimulation over the left dorsolateral prefrontal cortex during an episodic memory task.


Eligibility criteria: Inclusion Criteria:

* Written informed consent
* Right-handedness
* Non-smokers
* Native German speakers or comparable level of fluency
* Normal or corrected-to-normal vision

Exclusion Criteria:

* Neurological or psychiatric condition (other than diagnosed cognitive impairment)
* Past head injuries
* Magnetizable implants
* History of seizures
* Current or life-time alcohol or drug abuse
* Pregnancy
* Skin diseases

Primary outcomes:
measure: Episodic memory performance - learning curve
timeFrame: 0.25 hours
measure: Episodic memory performance - delayed recall 1
timeFrame: 20 min after encoding phase
measure: Episodic memory performance - delayed recall 2
timeFrame: 1 day after on-site visit
Secondary outcomes:
measure: Neurotransmitter levels
timeFrame: 0.5 hours
Other outcomes:
Locations:
city: Bern
country: Switzerland
facility: University Hospital of Old Age Psychiatry and Psychotherapy
Study officials:
affiliation: University Hospital of Old Age Psychiatry and Psychotherapy
name: Stefan Klöppel, Prof
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT05768685: The Experience of Affective Touch in Obesity
Official title: The Experience of Affective Touch in Obesity: the Role of Social Anhedonia and Lifespan Experiences
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Obesity
Keywords: affective touch
social anhedonia
lifespan bodily contacts
interpersonal relationships
Lead sponsor: Istituto Auxologico Italiano
Sponsor class: OTHER
First posted: 2023-03-14
Enrollment: 60
Sex: FEMALE
Minimum age (years): 18
Maximum age (years): 50
Standard ages: ADULT
Accepts healthy volunteers: yes
Observational model: CASE_CONTROL
Time perspective: CROSS_SECTIONAL
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Participants with obesity will be consecutively recruited during their rehabilitative treatment at the Istituto Auxologico Italiano, IRCCS, San Giuseppe Hospital (Italy)

Brief summary: The aim of the present research is to verify if the pleasantness of affective touch is comparable between women with obesity and healthy women, while measuring the level of social anhedonia and the lifespan experience of affective touch.


Eligibility criteria: Inclusion criteria:

* right-handed;
* diagnosis of obesity (i.e., the level of body mass index (BMI( greater than or equal to 30).

Exclusion Criteria:

* Concurrent neurological, neurodevelopmental (e.g., autism), motor, somatosensory and/or psychiatric disorders
* Evidence of any skin-related condition possibly affecting sensitivity on the participants' forearm (e.g., eczema, scars).

Primary outcomes:
measure: Rating of subjective pleasantness
timeFrame: baseline
Secondary outcomes:
measure: Social anhedonia score
timeFrame: baseline
measure: Affective experience score
timeFrame: baseline
Other outcomes:
Locations:
city: Piancavallo
country: Italy
facility: IRCCS Istituto Auxologico Italiano - Ospedale San Giuseppe
state: VCO
Study officials:
References:
Clinical trial NCT01455285: Effectiveness of the Transcutaneous Electrical Nerve Stimulation in Dysmenorrhea
Official title: Investigation of the Effectiveness of Different Modulations of Pulse Frequency Transcutaneous Electrical Nerve Stimulation in Dysmenorrhea
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Dysmenorrhea
Keywords: dysmenorrhea
transcutaneous electrical nerve stimulation (TENS
analgesia
pain visual analog scale
McGill pain questionnaire
Lead sponsor: Universidade Federal do Piauí
Sponsor class: OTHER
First posted: 2011-10-19
Sex: FEMALE
Minimum age (years): 16
Maximum age (years): 33
Standard ages: CHILD
ADULT
Accepts healthy volunteers: no
Primary purpose: TREATMENT

Brief summary: Hypothesis: What is the best modulation of pulse frequency in transcutaneous electrical nerve stimulation in dysmenorrhea? Purpose: To determine the effect of hypoalgesia frequency modulation pulse by transcutaneous electrical nerve (TENS) in dysmenorrhea. Methods: A controlled clinical study and prospective developed at the School of Physiotherapy Clinic / UFPI. Forty students were randomized into four distinct groups of the modulation frequency TENS: group 1 - 100 Hz, 100μs, group 2 - 4 Hz, 100μs, group 3 - placebo (apparatus off), group 4 - placebo induced (2 Hz, 40μs). All were initially evaluated by a questionnaire developed for the study, the visual analogue scale (VAS) (before, after 20, 30, 40, 50, 60 minutes) and the McGill Pain Questionnaire (before and after 20 minutes). The total duration of TENS application was 20 minutes and all protocols were performed in a single session. The analysis of variance (One-way ANOVA) followed by the Tukey procedure was applied to identify differences between experimental groups for each variable analyzed. The level of significance was p\< 0,05.


Eligibility criteria: Inclusion Criteria:

* be the first or second day of menstruation
* dysmenorrhea present at the time of application of TENS
* not having undergone any procedure analgesic six hours before the application of TENS

Exclusion Criteria:

* not to mention dysmenorrhea at the time of evaluation
* pregnant women
* were using some method of hormonal contraception on an ongoing basis
* had sensory deficits or cognitive and cases of contraindication to TENS application.

Primary outcomes:
Secondary outcomes:
Other outcomes:
Locations:
city: Parnaíba
country: Brazil
facility: School of Physiotherapy Clinic UFPI / Campus Minister Reis Velloso
state: Piauí
Study officials:
References:
citation: Proctor ML, Smith CA, Farquhar CM, Stones RW. Transcutaneous electrical nerve stimulation and acupuncture for primary dysmenorrhoea. Cochrane Database Syst Rev. 2002;2002(1):CD002123. doi: 10.1002/14651858.CD002123.
Clinical trial NCT00709085: To Study the Effects of Host Genetic Factors on Liver Cirrhosis and Hepatocellular Carcinoma (HCC)
Official title: Functional Genomics and Proteomics Towards and Understanding of Cell Signaling and Diseases--- Genomic and Proteomic Analyses of Liver Cells During Hepatitis Virus Infections and Cell Therapy (4/4)
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Liver Cirrhosis
Keywords: single nucleotide polymorphism
Lead sponsor: National Taiwan University Hospital
Sponsor class: OTHER
Collaborators: name: National Science and Technology Council, Taiwan
First posted: 2008-07-03
Enrollment: 320
Sex: ALL
Minimum age (years): 50
Maximum age (years): 70
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: CASE_CONTROL
Time perspective: RETROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: A total of 596 patients with histologically proven HCC were collected by Dr. Po-Huang Lee's Lab. (The Department of Surgery, National Taiwan University Hospital, Taipei, Taiwan)

Brief summary: The purpose of this study is to identify genetic determinants of susceptibility to liver cirrhosis and hepatocellular carcinoma. It will assist in predicting individual risks of disease progression and would help to clarify pathophysiologic mechanisms of liver cirrhosis and hepatocellular carcinoma.

Detailed description: Hepatocellular carcinoma (HCC) usually occurs in cirrhotic liver. Only 10-30% of HCC occur in non-cirrhotic liver. It has been suggested that etiological factors may differ for HCC which develop in cirrhotic liver: HCC in non-cirrhotic liver might be less often associated with viral infection and chronic alcoholism than HCC in cirrhotic livers. However, in any individual, the factors that determine HCC with or without cirrhosis remain unknown.

Cirrhosis is the end of fibrosis progression. The progress of liver fibrosis is a complex progress involving many cytokines related to activation of the hepatic stellate cells and progressive accumulation of extracellular matrix. The key enzymes responsible for deposition and degradation of all the protein component of extracellular matrix and basement membrane are matrix metalloproteinases.

To assess whether genetic variations in cytokines and matrix metalloproteinases result in diversity of liver cirrhosis and HCC, we conduct a case-control study of single nucleotide polymorphism analysis.

Eligibility criteria: Inclusion Criteria:

* Clinical diagnosis of hepatocellular carcinoma
* restrict the casual agent of liver disease to viral infection

Exclusion criteria:

* the casual aget of liver disease is not viral infection, such as alcohol abuse

Primary outcomes:
Secondary outcomes:
Other outcomes:
Locations:
city: Taipei
country: Taiwan
facility: National Taiwan University Hospital
Study officials:
affiliation: National Taiwan University College of Medicine
name: Ming-Fu Chang, Ph.D.
role: STUDY_CHAIR
References: