Clinical trial NCT03039556: Step-reduction in Older Men and Women
Official title: The Influence of Acute Physical Inactivity on Metabolic Function in Older Men and Women
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Older Adults
Reduced Physical Activity
Lead sponsor: McMaster University
Sponsor class: OTHER
Collaborators: name: Canadian Diabetes Association
First posted: 2017-02-01
Enrollment: 22
Sex: ALL
Minimum age (years): 65
Maximum age (years): 80
Standard ages: OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: BASIC_SCIENCE

Brief summary: This study investigates the effects of two weeks of reduced daily ambulation and a subsequent return to normal physical activity on metabolic health of older adults.

Detailed description: Aging results in a progressive loss of muscle mass that is accelerated by periods of muscular disuse, common for older adults during hospitalization or convalescence from illness. Transient physical inactivity has been shown to cause muscular atrophy and impairments in insulin sensitivity in both younger and older adults. However, the recovery capacity of older adults after such physical inactivity remains unknown. This study aims to determine the impact of two weeks of daily step reduction to ≤1000 steps per day, an experimental model mimicking short-term physical inactivity, on glycemic control in older adults and further investigate whether older adults are able to recover from the consequences of this inactivity simply by returning to their habitual activity for 14 days.

Eligibility criteria: Inclusion Criteria:

* Non-smoker

Exclusion Criteria:

* Use of assistive walking devices
* Chronic use of analgesic or anti-inflammatory drugs
* History of neuromuscular problems or muscle and/or bone wasting disease
* Acute or chronic illness including cardiac, pulmonary, liver or kidney abnormalities, uncontrolled hypertension, insulin or non-insulin dependent diabetes or other metabolic disorders
* Daily use of statins, particularly simvastatin and atorvastatin
* Use of medications known to affect protein metabolism
* Normally complete fewer than 3000 steps per day

Primary outcomes:
measure: Change in Insulin Sensitivity
timeFrame: Measured at the end of each behavioural intervention (Week 1, Week 3, Week 5)
Secondary outcomes:
measure: Change in lean tissue mass
timeFrame: Measured at the end of each behavioural intervention (Week 1, Week 3, Week 5)
measure: Change in Peak Isometric Maximal Voluntary Leg Extension Strength
timeFrame: Measured at the end of each behavioural intervention (Week 1, Week 3, Week 5)
measure: Change in Muscle Protein Synthesis
timeFrame: Measured at the end of each behavioural intervention (Week 1, Week 3, Week 5)
Other outcomes:
Locations:
city: Hamilton
country: Canada
facility: Exercise Metabolism Research Laboratory, McMaster Univeristy
state: Ontario
Study officials:
References:
citation: Breen L, Stokes KA, Churchward-Venne TA, Moore DR, Baker SK, Smith K, Atherton PJ, Phillips SM. Two weeks of reduced activity decreases leg lean mass and induces "anabolic resistance" of myofibrillar protein synthesis in healthy elderly. J Clin Endocrinol Metab. 2013 Jun;98(6):2604-12. doi: 10.1210/jc.2013-1502. Epub 2013 Apr 15.
citation: Devries MC, Breen L, Von Allmen M, MacDonald MJ, Moore DR, Offord EA, Horcajada MN, Breuille D, Phillips SM. Low-load resistance training during step-reduction attenuates declines in muscle mass and strength and enhances anabolic sensitivity in older men. Physiol Rep. 2015 Aug;3(8):e12493. doi: 10.14814/phy2.12493.
citation: McGlory C, von Allmen MT, Stokes T, Morton RW, Hector AJ, Lago BA, Raphenya AR, Smith BK, McArthur AG, Steinberg GR, Baker SK, Phillips SM. Failed Recovery of Glycemic Control and Myofibrillar Protein Synthesis With 2 wk of Physical Inactivity in Overweight, Prediabetic Older Adults. J Gerontol A Biol Sci Med Sci. 2018 Jul 9;73(8):1070-1077. doi: 10.1093/gerona/glx203.