Clinical trial NCT01573988: Satiety, Meal Frequency and Nutritional Aspects
Official title: Behavioural and Metabolic Consequences of Increasing Eating Frequency
Study type: INTERVENTIONAL
Overall status: TERMINATED
Phase: NA
Conditions: Volunteers
Keywords: Nutrition
Eating frequency
Food intake
Eating behavior
Satiety
Ghrelin
Lead sponsor: Hospices Civils de Lyon
Sponsor class: OTHER
First posted: 2012-04-10
Enrollment: 37
Sex: MALE
Minimum age (years): 20
Maximum age (years): 40
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: BASIC_SCIENCE

Brief summary: In this study, the investigators are interested in assessing the effects of the isocaloric increase of eating frequency on appetite and metabolism. How the consumption of an isocaloric breakfast in four intakes vs. one can modify satiety and appetite control in lean and obese subjects through :

* the physiological consequences : difference in postprandial kinetics of glucose, non esterified fatty acid, triglyceride, the secretion of satiety gut hormone (insulin, ghrelin, leptin and cholescystokinine (CCK), peptide YY (PYY), glucagon-like peptide-1 (GLP-1), nutrients oxidative fate and plasmatic oxidative stress (Malondialdehyde (MDA), glutathion, lipid hydroperoxides)
* eating behavior during an ad libitum buffet test meal


Eligibility criteria: Inclusion Criteria:

* No smokers
* BMI 20 to 35 kg/m2
* Moderate physical activity
* Safety during medical consultation
* Feeding behavioural phenotype (Dutch Eating Questionnaire, Three Eating Factor Questionnaire)

Exclusion Criteria:

* Medical history which may affect glucose metabolism (diabetes, renal or hepatic failure, thyroid dysfunction, Cushing syndrome, acromegaly...)
* Medical history which affect nutrient absorption (gastro-intestinal and pancreatic disease, gastrectomy, colectomy...)
* Drug use in the last two months that could affect glucose metabolism (steroids, topical gastric preparation, anorectic drugs...)
* Eating disorders
* Claustrophobic subjects

Primary outcomes:
measure: Ghrelin plasmatic concentration
timeFrame: 240 minutes after breakfast beginning (just before the lunch)
Secondary outcomes:
measure: Satiety through food intakes (quantitative) at the ad libitum buffet test meal
timeFrame: Since the beginning of the buffet test meal (240 minutes after breakfast beginning) to the end of the meal (at the latest 270 minutes after breakfast beginning).
measure: Satiety through visual analogue scale
timeFrame: 240 minutes after breakfast beginning (just before the lunch)
measure: Plasma metabolite concentrations (glycaemia, non esterified fatty acid,
timeFrame: kinetics during 430 minutes
measure: Endocrine concentrations (insulin, ghrelin, GLP-1, PYY, leptin, C-peptide)
timeFrame: kinetics during 430 minutes
measure: Plasma markers of oxidative stress (MDA, gluthation, lipid hydroxide)
timeFrame: kinetics during 430 minutes
measure: Lipid oxidation
timeFrame: kinetics during 430 minutes
measure: Eating behaviour at the buffet test meal by video recording (food choice, nutritional composition of the meal , kinetics of nutrient intake, meal structure, lunch duration)
timeFrame: during the buffet test meal (max : 30 minutes)
Other outcomes:
Locations:
city: Pierre Bénite
country: France
facility: Centre Hospitalier Lyon Sud - Centre de Recherche en Nutrition Humaine
Study officials:
References: