Clinical trial NCT06512311: Personalized Targeted Glioblastoma Therapies by ex Vivo Drug Screening
Official title: Personalized Targeted Glioblastoma Therapies by ex Vivo Drug Screening: Advanced Brain Tumor TheRApy Clinical Trial (ATTRACT)
Study type: INTERVENTIONAL
Overall status: RECRUITING
Phase: NA
Conditions: Glioblastoma
Lead sponsor: Medical University of Vienna
Sponsor class: OTHER
First posted: 2024-07-22
Enrollment: 240
Sex: ALL
Minimum age (years): 18
Maximum age (years): 75
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: OTHER

Brief summary: Patient derived cell line (PDC) -based drug screening will be applied to formulate a personalized treatment approach.

Detailed description: Patient derived cell line (PDC) -based drug screening will be applied to formulate a personalized treatment approach. Patients will be randomized between the investigational group receiving in addition to standard histology analysis also the PDC-based drug screening and the standard group receiving only standard histology analysis. Outcome results will be compared in a randomized, interventional clinical performance study. The PDC-based drug screening will be performed only in accordance with the approved Performance Study Plan on subjects who have signed an informed consent form.

Eligibility criteria: Inclusion Criteria:

* Age 18-75
* ECOG performance status 0-2
* Newly diagnosed glioblastoma, IDH wildtype - according to the 2021 WHO classification of Tumors of the Central Nervous System
* MGMT promotor unmethylated per local investigator
* Tissue available for drug screening (successful PDC establishment from surgical material)
* Scheduled for concomitant radio-chemotherapy with temozolomide
* Written informed consent

Exclusion Criteria:

* Current participation in another therapeutic clinical trial
* Patients with a concurrent malignancy or malignancy within five years prior of study enrolment except for carcinoma in situ of the cervix, non-melanoma skin carcinoma or stage I uterine cancer within the last 3 years
* Pregnant or lactating women
* Current known infection with hepatitis B virus (HBV), or hepatitis C virus (HCV). Patients with past HBV infection or resolved HBV infection (defined as having a negative hepatitis B surface antibody \[HBsAg\] test and a positive anti-hepatitis B core antibody \[HBcAb\] test, accompanied by a negative HBV DNA test) are eligible. Patients positive for anti-HCV antibody are eligible only if polymerase chain reaction (PCR) is negative for HCV RNA.
* Known human immunodeficiency virus (HIV) infection that is not well controlled. All of the following criteria are required to define an HIV infection that is well controlled: undetectable viral RNA, CD4+ count ≥350 cells/mm3 , no history of AIDS-defining opportunistic infection within the past 12 months, and stable for at least 4 weeks on the same anti-HIV medications (meaning there are no expected further changes in that time to the number or type of antiretroviral drugs in the regimen). If an HIV infection meets the above criteria, monitoring of viral RNA load and CD4+ count is recommended.
* Any of the following co-morbidities:

  * Pre-existing severe peripheral neuropathy (\> CTCAE grade 2)
  * Hepatic impairment (Bilirubin Level \>1.5x-3x ULN)
  * Kidney dysfunction (CrCl \< 59 mL/min)
  * Cardiac dysfunction with left ventricular ejection fraction \<60 %
  * Any grade of interstitial lung disease
  * Ongoing or previous history of rhabdomyolysis
  * Acute pancreatitis
  * QTcF ≥480 msec
  * Diabetes mellitus with fasting glucose \> 250mg/dl or 13.9 mmol/L
* Participants who are unable or unwilling to comply with the requirements of the protocol as assessed by the investigator.

Primary outcomes:
measure: Overall survival time
timeFrame: From date of randomization until date of death from any cause or last follow up whichever came first, assessed up to 144 months
Secondary outcomes:
measure: Feasibility of PDC-based drug screening
timeFrame: From date of randomization until date of communication of the tumor board outcome, asses up to 144 months
measure: Comparison of Quality of life measurements
timeFrame: From date of randomization until date of death from any cause or last follow up whichever came first, assessed up to 144 months
measure: Comparison of neurocognitive function scale
timeFrame: From date of randomization until date of death from any cause or last follow up whichever came first, assessed up to 144 months
Other outcomes:
Locations:
city: Vienna
country: Austria
facility: AKH Vienna, Department for Internal Medicine I, Oncology
Study officials:
References: