Clinical trial NCT06333756: Effects of Muscle Strengthening and Fatigue on Activities in Cortex and Muscle
Official title: Effects of Cross Education Training on Corticocortical and Corticomuscular Functional Connectivity
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Healthy Adults
Keywords: cross education, functional connectivity
Lead sponsor: National Yang Ming Chiao Tung University
Sponsor class: OTHER
First posted: 2024-03-27
Enrollment: 40
Sex: ALL
Minimum age (years): 20
Maximum age (years): 40
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: NA
Intervention model: SINGLE_GROUP
Intervention model description: Parallel Assignment
Primary purpose: BASIC_SCIENCE

Brief summary: We will explored the effect of cross education training on different cortex functional connectivity, cortex and muscle functional connectivity, and maximal voluntary contraction.

Healthy participants receive cross education training of the elbow flexor (12 rep./set, 3sets, 60%MVC, 180°/s, eccentric).Maximal voluntary contraction, electroencephalogram and electromyogram will record during cross education tasks to determine the effects of cross education training on cortical network and muscle functional connectivity

Detailed description: Cross education (CE) training was observed in 1894, when unilateral strength training of single limb was found to increase in strength of untrained muscle group. CE has potential clinical relevance in rehabilitation for patient who have acute injuries of the limb, post-surgical limb immobilization and certain neurological disorders with unilateral muscle weakness. Although CE has several potential clinical application, the precise physiological mechanisms underlying CE remains unknown. Previous studies reported that CE may involve bilateral cortical activity in both contralateral primary motor cortex (cM1), and ipsilateral primary motor cortex (iM1).In addition, neuroimaging studies have demonstrated that bilateral supplementary motor area, but CE immediate change of functional connectivity in cortical network remains unknown.

The purposes of this study are to investigate the immediate effect of CE training of biceps brachii (1) Immediate change of functional connectivity in cortical network; (2) Immediate change of functional connectivity in cortex and target muscle; (3) Explore immediate change of corticomuscular functional connectivity on maximal voluntary contraction. We hypothesize that (1) Bilateral cortical motor network that exhibit changes in functional connectivity during cross education; (2) Cross education would immediately enhance functional connectivity between cortex and target muscle; (3) Cross education would immediately change corticomuscular functional connectivity on maximal isometric voluntary contraction.

Eligibility criteria: Inclusion Criteria:

1. Healthy adults who are 20-40 years old

Exclusion Criteria:

1. Upper extremity (UE) pain or discomfort
2. Medical condition that substantially influenced their UE strength
3. Experience of UE surgery
4. Paresthesia in UE
5. Open wound on UE

Primary outcomes:
measure: Corticocortical coherence
timeFrame: Measured immediately after cross education training
measure: Corticomuscular coherence
timeFrame: Measured immediately after cross education training
measure: Maximal voluntary contraction
timeFrame: Measured immediately after cross education training
Secondary outcomes:
Other outcomes:
Locations:
city: Taipei
country: Taiwan
facility: National Yang-Ming University
Study officials:
affiliation: Department of Physical Therapy and Assistive and Technology ,National Yang-Ming University
name: Li-Wei Chou, Ph.D.
role: PRINCIPAL_INVESTIGATOR
References: