Clinical trial NCT00318578: Prognosis Factors Associated With Convulsive Status Epilepticus in Adults
Official title: Prognosis Factors Associated With Convulsive Status Epilepticus in Adults: A Multicenter Cohort Study
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Status Epilepticus
Keywords: convulsive status epilepticus
outcome
prognosis factors
seizure duration
adult
electroencephalogram
intensive care unit
Lead sponsor: Versailles Hospital
Sponsor class: OTHER
First posted: 2006-04-27
Enrollment: 100
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: DEFINED_POPULATION
Time perspective: PROSPECTIVE

Brief summary: The aim of the study is to evaluate, prospectively, prognosis factors associated with convulsive status epilepticus (CSE) in adults hospitalized in intensive care units.

Detailed description: Status epilepticus is a neurologic and medical emergency associated with high mortality and morbidity rates. According to the operational definition Convulsive Status Epilepticus (CSE) is defined as a single clinical seizure lasting more than 10 min, or two or more repeated seizures over a period of more than 10 minutes without intervening recovery of consciousness.

There are a few to date in literature reporting prognosis factors associated with this condition and, at this time, there are no published data considering an operational definition of CSE.

In a retrospective study considering an operational definition we identified a seizure duration of 15 min associated with poor outcome (not yet published).

The principal goal of this study is to evaluate factors associated with outcome in CSE, in particular seizure duration of more than 15 minutes.

The secondary goals are to evaluate the epidemiology and management at every stage of CSE thus redefined.

Eligibility criteria: Inclusion Criteria:

* More than 18 years old
* Convulsive status epilepticus according to operational definition as any seizure lasting for 10 minutes or longer, or two or more intermittent seizures lasting for greater than 10 minutes from which the patient did not regain consciousness.
* Beginning of seizure less than 12 hours before intensive care unit admission
* Convulsive status epilepticus occurring during intensive care unit stay

Exclusion Criteria:

* Less than 18 years old
* Patients that seized up to 9 minutes
* Beginning of seizure more than 12 hours before intensive care unit admission

Primary outcomes:
Secondary outcomes:
Other outcomes:
Locations:
city: Abbeville
country: France
facility: Centre Hospitalier d'Abbeville
city: Annonay
country: France
facility: Centre Hospitalier d'Annonay
city: Argenteuil
country: France
facility: Centre Hospitalier Victor Dupouy
city: Aulnay Sous Bois
country: France
facility: Centre Hospitalier Robert Ballanger
city: Cergy Pontoise
country: France
facility: Centre Hospitalier Rene Dubos
city: Chartres
country: France
facility: Centre Hospitalier de Chartres
city: Châlons-en-Champagne
country: France
facility: Centre Hospitalier de Châlons-en-Champagne
city: Clamart
country: France
facility: Centre Hospitalier Universitaire Antoine Beclere
city: Clermont Ferrand
country: France
facility: Hopital Gabriel Montpied
city: Compiegne
country: France
facility: Centre Hospitalier de Compiegne
city: Creteil
country: France
facility: Centre Hospitalier Universitaire Henri Mondor
city: Dourdan
country: France
facility: Centre Hospitalier de Dourdan
city: Dreux
country: France
facility: Centre Hospitalier de Dreux
city: Grenoble
country: France
facility: Centre Hospitalier Universitaire de Grenoble
city: Le Chesnay
country: France
facility: Centre Hospitalier de Versailles
city: Marseille
country: France
facility: Centre Hospitalier Universitaire La Timone
city: Maubeuge
country: France
facility: Centre Hospitalier Sambre Avesnois
city: Meaux
country: France
facility: Centre Hospitalier de Meaux
city: Nancy
country: France
facility: Centre Hospitalier Universitaire de Nancy
city: Nevers
country: France
facility: Centre Hospitalier Pierre Bérégovoy
city: Nice
country: France
facility: Centre Hôspitalier ARCHET
city: Niort
country: France
facility: Centre Hospitalier Georges Renon
city: Orleans
country: France
facility: Centre Hospitalier Universitaire d'Orléans
city: Paris
country: France
facility: Centre Hospitalier Universitaire Cochin
city: Paris
country: France
facility: Centre Hospitalier Universitaire Lariboisiere
city: Paris
country: France
facility: Centre Hospitalier Bichat Claude Bernard
city: Paris
country: France
facility: Fondation Hopital Saint Joseph
city: PAU
country: France
facility: Centre Hospitalier Francois Mitterrand
city: Pessac
country: France
facility: Clinique Mutualiste de Pessas
city: Poitiers
country: France
facility: Centre Hospitalier Universitaire de Poitiers
city: Roanne
country: France
facility: Centre Hospitalier de Roanne
city: Rodez
country: France
facility: Centre Hospitalier de Rodez
city: Saint Lo
country: France
facility: Centre Hospitalier Mémorail France Etats Unis Saint Lo
city: Suresnes
country: France
facility: Centre Hospitalier Foch
Study officials:
affiliation: Versailles Hospital
name: Stephane LEGRIEL, MD
role: PRINCIPAL_INVESTIGATOR
affiliation: Centre Hospitalier Bichat Claude Bernard
name: Bruno MOURVILLIER, MD
role: PRINCIPAL_INVESTIGATOR
References: