Clinical trial NCT01798485: A Phase 3 Study of Ganetespib in Combination With Docetaxel Versus Docetaxel Alone in Patients With Advanced NSCLC
Official title: A Randomized, Phase 3 Study of Ganetespib in Combination With Docetaxel Versus Docetaxel Alone in Patients With Advanced Non-Small-Cell Lung Adenocarcinoma
Study type: INTERVENTIONAL
Overall status: TERMINATED
Phase: PHASE3
Conditions: Non-Small-Cell Lung Adenocarcinoma
Non-small Cell Lung Cancer Stage IIIB
Non-small Cell Lung Cancer Stage IV
Non-small Cell Lung Cancer Metastatic
Lead sponsor: Synta Pharmaceuticals Corp.
Sponsor class: INDUSTRY
First posted: 2013-02-25
Enrollment: 696
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The purpose of this study is to determine whether combining ganetespib (STA-9090) with docetaxel is more effective than docetaxel alone in the treatment of patients with advanced non-small cell lung cancer.

Detailed description: Preliminary signals of clinical activity of ganetespib as a single agent have been observed in patients with advanced NSCLC. A Phase 2b/3 Study (9090-08) was initiated to evaluate the safety and activity of ganetespib in combination with docetaxel vs. docetaxel alone in NSCLC. Study 9090-08 is ongoing. Results from an interim analysis show that the combination has been well tolerated and an encouraging improvement in efficacy, including overall survival (OS) has been observed.

Update: An independent data monitoring committee (DMC) was established to review accumulating unblinded safety data, and efficacy data at two specified Interim Analyses. The DMC monitored the conduct of the trial (including the accrual/retention of patients) and reviewed the risks and benefits. The study was stopped after the first Interim Analysis due to futility.

The efficacy portion of this report is based on a 05 October 2015 data cut after the number of protocol-defined death events (336) for the first interim analysis had been achieved. The safety portion is based on the final database locked on 23 December 2015.

Eligibility criteria: Inclusion Criteria:

* Advanced Stage IIIB or IV non-small-cell lung cancer (NSCLC)
* Eastern Oncology Cooperative Group (ECOG) Performance Status 0 or 1
* Prior therapy defined as 1 prior systemic therapy for advanced disease
* Documented disease progression during or following most first line therapy for advanced disease
* Adequate hematologic, hepatic, renal function

Exclusion Criteria:

* Epidermal growth factor receptor (EGFR) mutations
* Anaplastic lymphoma kinase (ALK) translocations
* Predominantly squamous, adenosquamous or unclear histologic type
* Active or untreated central nervous system (CNS) metastases
* Active malignancies other than NSCLC within the last 5 years with the exception of adequately treated cone-biopsied in situ carcinoma of the cervix uteri or basal or squamous cell carcinoma of the skin
* Serious cardiac illness or medical conditions
* Pregnant or lactating women
* Uncontrolled intercurrent illness

Primary outcomes:
measure: Overall Survival as of 19 October 2015
timeFrame: up to 36 months
Secondary outcomes:
measure: Progression-free Survival (PFS) as of 19 October 2015
timeFrame: up to 36 months
measure: Overall Survival (OS) In Participants With an Elevated Screening Lactate Dehydrogenase (eLDH) as of 19 October 2015
timeFrame: up to 36 months
measure: Objective Response Rate (ORR) as of 19 October 2015
timeFrame: up to 36 months
measure: Disease Control Rate (DCR) as of 19 October 2015
timeFrame: up to 36 months
measure: Kaplan-Meier Estimate of Duration of Response (DOR) as of 19 October 2015
timeFrame: up to 36 months
measure: Progression Free Survival (PFS) in Participants With an Elevated Screening Lactate Dehydrogenase (eLDH) as of 19 October 2015
timeFrame: up to 36 months
measure: Objective Response Rate (ORR) in Participants With an Elevated Screening Lactate Dehydrogenase (eLDH) as of 19 October 2015
timeFrame: up to 36 months
measure: Disease Control Rate (DCR) in Participants With an Elevated Screening Lactate Dehydrogenase (eLDH) as of 19 October 2015
timeFrame: up to 36 months
measure: Kaplan-Meier Estimate for Time to Emergence of New Metastatic Lesion (TNL) as of 19 October 2015
timeFrame: up to 36 months
measure: Percentage of Participants With Progressive Disease Due to Any New Metastatic Lesion as of 19 October 2015
timeFrame: up to 36 months
measure: Participants With Treatment-Emergent Adverse Events as of 23 December 2015
timeFrame: up to 36 months
measure: Patient-Reported Quality of Life as Measured by the European Quality Of Life - Five Dimensions - Three Levels (EQ-5D-3L) Survey
timeFrame: Day 1 (pre-treatment), Day 63 (Cycle 3 Day 1), Day 105 (Cycle 5 Day 1) and end of trial
measure: Patient-Reported Symptom Improvement as Measured by the Functional Assessment of Cancer Therapy - Lung (FACT-L) Version 4 Test
timeFrame: Day 1 (pre-treatment), Day 63 (Cycle 3 Day 1), Day 105 (Cycle 5 Day 1) and end of trial
Other outcomes:
measure: Exploratory Biomarker Analyses
timeFrame: up to 36 months
Locations:
city: Flagstaff
country: United States
facility: Arizona Oncology Associates PC- NAHOA
state: Arizona
city: Prescott Valley
country: United States
facility: Arizona Oncology Associates, PC- NAHOA
state: Arizona
city: Sedona
country: United States
facility: Northern Arizona Hematology & Oncology Associates
state: Arizona
city: Tucson
country: United States
facility: Arizona Clinical Research Center, Inc.
state: Arizona
city: Anaheim
country: United States
facility: Pacific Cancer Medical Center, Inc
state: California
city: Bakersfield
country: United States
facility: Comprehensive Blood & Cancer Center
state: California
city: Duarte
country: United States
facility: City of Hope Comprehensive Breast Cancer Center
state: California
city: La Jolla
country: United States
facility: UC San Diego Moores Cancer Center
state: California
city: Loma Linda
country: United States
facility: Loma Linda University Cancer Center
state: California
city: Los Angeles
country: United States
facility: VA Greater Los Angeles Healthcare System
state: California
city: Los Angeles
country: United States
facility: Ronald Reagan UCLA Medical Center
state: California
city: Orange
country: United States
facility: St. Joseph Hospital, Center for Cancer Prevention and Treatment
state: California
city: Redondo Beach
country: United States
facility: Cancer Care Associates Medical Group, Inc.
state: California
city: Sacramento
country: United States
facility: UC Davis Medical Center - UC Davis Comprehensive Cancer
state: California
city: Santa Barbara
country: United States
facility: Santa Barbara Hematology Oncology Medical Group, Inc.
state: California
city: South Pasadena
country: United States
facility: City of Hope- South Pasadena
state: California
city: Denver
country: United States
facility: Rocky Mountain Cancer Center
state: Colorado
city: Norwich
country: United States
facility: Eastern Connecticut Hematology Associates
state: Connecticut
city: Newark
country: United States
facility: Medical Oncology Hematology Consultants, PA
state: Delaware
city: Boca Raton
country: United States
facility: Lynn Cancer Institute Center for Hematology Oncology
state: Florida
city: Daytona Beach
country: United States
facility: Halifax Health - Medical Center
state: Florida
city: Deerfield Beach
country: United States
facility: University of Miami Health System Sylvester at Deerfield Beach
state: Florida
city: Hollywood
country: United States
facility: Memorial Regional Hospital
state: Florida
city: Miami
country: United States
facility: Baptist Health Medical Group Oncology, LLC
state: Florida
city: Tampa
country: United States
facility: University of South Florida - H. Lee Moffitt
state: Florida
city: West Palm Beach
country: United States
facility: Palm Beach Cancer Institute
state: Florida
city: Atlanta
country: United States
facility: Emory University - Winship Cancer Institute
state: Georgia
city: Marietta
country: United States
facility: Northwest Georgia Oncology Centers, PC
state: Georgia
city: Chicago
country: United States
facility: University Of Chicago Medical Center
state: Illinois
city: Decatur
country: United States
facility: Cancer Care Specialists of Central Illinois, S.C.
state: Illinois
city: Rockford
country: United States
facility: Saint Anthony Medical Center
state: Illinois
city: Fort Wayne
country: United States
facility: Fort Wayne Medical Oncology and Hematology Inc
state: Indiana
city: Annapolis
country: United States
facility: AAMC Oncology and Hematology
state: Maryland
city: Bethesda
country: United States
facility: The Center for Cancer and Blood Disorders (CCBD) - Bethesda
state: Maryland
city: Hagerstown
country: United States
facility: The John R Marsh Cancer Center
state: Maryland
city: Boston
country: United States
facility: Dana Farber Cancer Institute
state: Massachusetts
city: Boston
country: United States
facility: Dana Farber Cancer Institute
state: Massachusetts
city: Detroit
country: United States
facility: Henry Ford Hospital
state: Michigan
city: Lansing
country: United States
facility: Sparrow Regional Cancer Center
state: Michigan
city: Duluth
country: United States
facility: St. Luke's Hospital Duluth
state: Minnesota
city: Saint Louis Park
country: United States
facility: Frauenshuh Cancer Center
state: Minnesota
city: Bridgeton
country: United States
facility: St. Louis Cancer Care, LLP - North County
state: Missouri
city: Reno
country: United States
facility: Renown Regional Medical Center
state: Nevada
city: Hackensack
country: United States
facility: Hackensack University Medical Center - John Theurer Cancer Center
state: New Jersey
city: Albuquerque
country: United States
facility: New Mexico Cancer Center
state: New Mexico
city: East Setauket
country: United States
facility: North Shore Hematology Oncology Associates
state: New York
city: Lake Success
country: United States
facility: Clinical Research Alliance
state: New York
city: Chapel Hill
country: United States
facility: University Of North Carolina At Chapel Hill
state: North Carolina
city: Charlotte
country: United States
facility: Novant Health Presbyterian Medical Center
state: North Carolina
city: Wilmington
country: United States
facility: New Hanover Regional Medical Center - Zimmer Cancer Center
state: North Carolina
city: Winston-Salem
country: United States
facility: Novant Health Oncology Specialists
state: North Carolina
city: Tulsa
country: United States
facility: Tulsa Cancer Institute, PLLC
state: Oklahoma
city: Portland
country: United States
facility: Kaiser Permanente Northwest
state: Oregon
city: Pittsburgh
country: United States
facility: University of Pittsburgh Medical Center
state: Pennsylvania
city: Sayre
country: United States
facility: Guthrie Medical Group, PC
state: Pennsylvania
city: Rapid City
country: United States
facility: Rapid City Regional Hospital
state: South Dakota
city: Watertown
country: United States
facility: Prairie Lakes Healthcare System
state: South Dakota
city: Chattanooga
country: United States
facility: Erlanger Institute for Clinical Research
state: Tennessee
city: Chattanooga
country: United States
facility: Associates In Oncology and Hematology
state: Tennessee
city: Knoxville
country: United States
facility: Thompson Cancer Survival Center
state: Tennessee
city: Arlington
country: United States
facility: Texas Oncology-Arlington North
state: Texas
city: Arlington
country: United States
facility: Texas Oncology - Arlington South
state: Texas
city: Beaumont
country: United States
facility: Texas Oncology, P.A.
state: Texas
city: Dallas
country: United States
facility: Texas Oncology, PA
state: Texas
city: Dallas
country: United States
facility: Simmons Comprehensive Cancer Center
state: Texas
city: Houston
country: United States
facility: Houston Methodist Hospital Research Institute
state: Texas
city: Houston
country: United States
facility: Millennium Oncology
state: Texas
city: Lubbock
country: United States
facility: Joe Arrington Cancer Research and Treatment Center
state: Texas
city: San Antonio
country: United States
facility: Cancer Care Centers Of South Texas
state: Texas
city: San Antonio
country: United States
facility: Cancer Care Centers Of South Texas
state: Texas
city: San Antonio
country: United States
facility: Cancer Care Centers of South Texas
state: Texas
city: Sherman
country: United States
facility: Texas Oncology - Sherman
state: Texas
city: Everett
country: United States
facility: Providence Regional Medical Center Everett
state: Washington
city: Spokane Valley
country: United States
facility: Cancer Care Northwest
state: Washington
city: Tacoma
country: United States
facility: Northwest Medical Specialties, PLLC
state: Washington
city: Morgantown
country: United States
facility: Mary Babb Cancer Center
state: West Virginia
city: Green Bay
country: United States
facility: Green Bay Oncology, Ltd. - St. Mary's Site
state: Wisconsin
city: Green Bay
country: United States
facility: Green Bay Oncology
state: Wisconsin
city: Krems
country: Austria
facility: Landesklinikum Krems
state: Niederösterreich
city: Linz
country: Austria
facility: Krankenhaus Der Barmherzigen Schwestern
state: Oberösterreich
city: Wels
country: Austria
facility: Klinikum Wels-Grieskirchen
state: Oberösterreich
city: Kufstein
country: Austria
facility: Bezirkskrankenhaus Kufstein [Onkologie]
state: Tirol
city: Linz
country: Austria
facility: Allgemeines Krankenhaus Linz
city: Linz
country: Austria
facility: Elisabeth Linz Hospital
city: Wien
country: Austria
facility: Otto Wagner Spital
city: Wien
country: Austria
facility: Sozialmedizinisches Zentrum Baumgartner Höhe
city: Mechelen
country: Belgium
facility: AZ Sint-Maarten - Campus Leopoldstraat
state: Antwerpen
city: Ottignies
country: Belgium
facility: Clinique Saint-Pierre Ottignies
state: Brabant Wallon
city: Charleroi
country: Belgium
facility: Grand Hôpital de Charleroi - Site Notre-Dame
state: Hainaut
city: Haine St. Paul
country: Belgium
facility: INDC Entité Jolimontoise - Polyclinique de Jolimont
state: Hainaut
city: Yvoir
country: Belgium
facility: CHU Dinant Godinne UCL Namur
state: Namur
city: Roeselaere
country: Belgium
facility: Algemeen Stedelijk Ziekenhuis - Campus Aalst
state: West-Vlaanderen
city: Bruxelles
country: Belgium
facility: Cliniques Universitaire Saint-Luc
city: Liège
country: Belgium
facility: CHR de la Citadelle - Site Citadelle
city: Banja Luka
country: Bosnia and Herzegovina
facility: Clinical Centre Banja Luka
state: Republika Srpska
city: Tuzla
country: Bosnia and Herzegovina
facility: University Clinical Center Tuzla
state: Tuzlanski kanton
city: Mostar
country: Bosnia and Herzegovina
facility: Clinical Hospital Mostar
city: Sarajevo
country: Bosnia and Herzegovina
facility: Clinical Center University of Sarajevo, Clinic of Oncology
city: Sarajevo
country: Bosnia and Herzegovina
facility: University Clinical Centre Sarajevo
city: Tuzla
country: Bosnia and Herzegovina
facility: University Clinical Center Tuzla
city: Zenica
country: Bosnia and Herzegovina
facility: Kantonalna bolnica Zenica
city: Toronto
country: Canada
facility: Princess Margaret Hospital
state: Ontario
city: Montreal
country: Canada
facility: Mc Gill University-MUHC
state: Quebec
city: Zagreb
country: Croatia
facility: University Hospital Center Zagreb
state: Grad Zagreb
city: Pula
country: Croatia
facility: Opca bolnica Pula
state: Istarska županija
city: Olomouc
country: Czech Republic
facility: Fakultni nemocnice Olomouc
city: Ostrava - Poruba
country: Czech Republic
facility: Fakultni nemocnice Ostrava
city: Prague
country: Czech Republic
facility: Vseobecna fakultni nemocnice v Praze
city: Prague
country: Czech Republic
facility: Nemocnice Na Bulovce
city: Gap
country: France
facility: CHI des Alpes du Sud
state: Hautes-Alpes
city: Bayonne
country: France
facility: Centre D'Oncologie Du Pays Basque
state: Pyrénées-Atlantiques
city: Villefranche Sur Saone
country: France
facility: Centre Hosptalier De Villefranche-Sur-Saone
state: Rhône
city: Creteil
country: France
facility: Chi creteil
state: Val-de-Marne
city: Grenoble
country: France
facility: Chu De Grenoble - Hopital Michallon
city: Lyon
country: France
facility: Centre Léon Bérard
city: Paris
country: France
facility: Groupe Hospitalier Cochin
city: Rennes
country: France
facility: Centre Hospitalier Universitaire de Rennes - Hopital d
city: Rouen
country: France
facility: Hôpital Charles Nicolle
city: Strasbourg
country: France
facility: CHRU de Strasbourg
city: Freiburg
country: Germany
facility: Universitätsklinikum Freiburg
state: Baden-Württemberg
city: Ulm
country: Germany
facility: Universiaetsklinikum Ulm
state: Baden-Württemberg
city: Villingen-Schwenningen
country: Germany
facility: Schwarzwald-Baar-Klinikum
state: Baden-Württemberg
city: Gauting
country: Germany
facility: Asklepios Fachklinik München-Gauting
state: Bayern
city: Muenchen
country: Germany
facility: Klinikum Bogenhausen
state: Bayern
city: Bad Nauheim
country: Germany
facility: Gesundheitszentrum Wetterau
state: Hessen
city: Frankfurt
country: Germany
facility: Johann Wolfgang Goethe University Clinic Frankfurt
state: Hessen
city: Frankfurt
country: Germany
facility: Johann Wolfgang Goethe University Clinic Frankfurt
state: Hessen
city: Kassel
country: Germany
facility: Klinikum Kassel
state: Hessen
city: Köln
country: Germany
facility: Kliniken der Stadt Köln gGmbH
state: Nordrhein-Westfalen
city: Homburg
country: Germany
facility: Universitaetsklinikum des Saarlandes
state: Saarland
city: Leipzig
country: Germany
facility: Universitätsklinikum Leipzig [Pneumologie]
state: Sachsen
city: Großhansdorf
country: Germany
facility: Pneumologisches Forschungsinstitut an der Lungenclinic Gross
state: Schleswig-Holstein
city: Berlin
country: Germany
facility: MVZ Äerzteforum Seestraße
city: Bielefeld
country: Germany
facility: Ev. Krankenhaus Bielefeld
city: Frankfurt/Oder
country: Germany
facility: Klinikum Frankfurt An Der Oder
city: Hamburg
country: Germany
facility: Practice Laack
city: Lübeck
country: Germany
facility: Unikl. Schleswig-Holstein - Lübeck
city: Mainz
country: Germany
facility: J. Gutenberg Uni.Mainz
city: Mannheim
country: Germany
facility: Medizinische Fakultät Mannheim Uni Heidelberg
city: Muenster
country: Germany
facility: Gemeinschaftspraxis fuer Haematologie und Onkologie
city: Offenbach
country: Germany
facility: Klinikum Offenbach GmbH
city: Deszk
country: Hungary
facility: Csongrád Megyei Önkormányzat Mellkasi Betegségek Szakkó
state: Csongrád
city: Székesfehérvár
country: Hungary
facility: Fejér Megyei Szent György Egyetemi Oktató Kórház
state: Fejér
city: Budapest
country: Hungary
facility: Országos Korányi TBC és Pulmonológiai Intézet
state: Pest
city: Budapest
country: Hungary
facility: Semmelweis Egyetem
city: Budapest
country: Hungary
facility: Országos Korányi TBC és Pulmonológiai Intézet
city: Gyula
country: Hungary
facility: Békés Megyei Pándy Kálmán Kórház
city: Miskolc
country: Hungary
facility: CRU Hungary Kft.
city: Meldola
country: Italy
facility: Irccs Irst
state: Forli
city: Viterbo
country: Italy
facility: Presidio Ospedaliero Centrale Belcolle, AUSL Viterbo
state: Lazio
city: Monza
country: Italy
facility: Azienda Ospedaliera San Gerardo
state: Lombardia
city: Aviano
country: Italy
facility: CRO, IRCCS, Istituto Nazionale Tumori
state: Pordenone
city: Rome
country: Italy
facility: Azienda Policlinico Umberto I
state: Roma
city: Bologna
country: Italy
facility: Policlinico S.Orsola Malpighi, AOU di Bologna
city: Genova
country: Italy
facility: AOU S.Martino, IRCCS, IST-Istituto Nazionale Ricerca Sul Can
city: Milano
country: Italy
facility: Istituto Europeo di Oncologia, Istituto di Ricovero e Cura a
city: Padova
country: Italy
facility: Iov-Irccs
city: Perugia
country: Italy
facility: Ospedale S.Maria della Misericordia, AO di Perugia, Universi
city: Piacenza
country: Italy
facility: Ospedale Guglielmo da Saliceto, AUSL Piacenza
city: Roma
country: Italy
facility: Istituti Fisioterapici Ospitalieri Regina Elena
city: Verona
country: Italy
facility: Borgo Roma, Policlinico G.Rossi, AOU Integrata Verona
city: Assen
country: Netherlands
facility: Ziekenhuis Assen
state: Drenthe
city: Harderwijk
country: Netherlands
facility: Ziekenhuis St Jansdal
state: Gelderland
city: Zutphen
country: Netherlands
facility: Gelre Ziekenhuis Zutphen
state: Gelderland
city: Maastricht
country: Netherlands
facility: academisch ziekenhuis Maastricht
state: Limburg
city: Zwolle
country: Netherlands
facility: Isala Klinieken Zwolle
state: Overijssel
city: Utrecht
country: Netherlands
facility: Sint Antoniusziekenhuis, location Utrecht
city: Lodz
country: Poland
facility: Wojewodzki Szpital Specjalistyczny im. M.Kopernika
state: Lodzkie
city: Krakow
country: Poland
facility: Medica Pro Familia Sp. z o.o. S.K.A.
state: Malopolskie
city: Otwock
country: Poland
facility: Mazowieckie Centrum Leczenia Chorob Pluc i Gruzlicy
state: Mazowieckie
city: Warszawa
country: Poland
facility: Centrum Onkologii - Instytut im. Marii Sklodowskiej - Curie
state: Mazowieckie
city: Bialystok
country: Poland
facility: Uniwersytecki Szpital Kliniczny w Bialymstoku
state: Podlaskie
city: Lomza
country: Poland
facility: Szpital Wojewodzki w Lomzy im. Kardynala S. Wyszynskiego
state: Podlaskie
city: Elblag
country: Poland
facility: Szpital Wojewodzki Zespolony
state: Warminsko-mazurskie
city: Poznan
country: Poland
facility: NZOZ Med Polonia
state: Wielkopolskie
city: Poznan
country: Poland
facility: Wielkopolskie Centrum Pulmonologii i Torakochirurgii
state: Wielkopolskie
city: Olsztyn
country: Poland
facility: Samodzielny Publiczny Zespol Gruzlicy i Chorob Pluc
city: Pilchowice
country: Poland
facility: Szpital Chorob Pluc im. Sw. Jozefa w Pilchowicach
city: Prabuty
country: Poland
facility: Szpital Specjalistyczny
city: Bucharest
country: Romania
facility: Institutul Oncologic "Prof. Dr. Alex. Trestioreanu"
city: Bucharest
country: Romania
facility: Spitalul Universitar de Urgenta Bucuresti
city: Bucuresti
country: Romania
facility: Spitalul Clinic Coltea
city: Cluj Napoca
country: Romania
facility: Institutul Oncologic "Prof.Dr.I.Chiricuta" Cluj Napoca
city: Cluj Napoca
country: Romania
facility: Medisprof
city: Cluj-Napoca
country: Romania
facility: Institutul Oncologic "Prof.Dr.I.Chiricuta" Cluj Napoca
city: Craiova
country: Romania
facility: Centrul de Oncologie Sf. Nectarie
city: Iasi
country: Romania
facility: Institutul Regional de Oncologie Iasi
city: Timisoara
country: Romania
facility: Oncomed
city: Chelyabinsk
country: Russian Federation
facility: Synta Pharmaceuticals Investigational Site
city: Ekaterinburg
country: Russian Federation
facility: Synta Pharmaceuticals Investigational Site
city: Ivanovo
country: Russian Federation
facility: Synta Pharmaceuticals Investigational Site
city: Izhevsk
country: Russian Federation
facility: Synta Pharmaceuticals Investigational Site
city: Kemerovo
country: Russian Federation
facility: Synta Pharmaceuticals Investigational Site
city: Krasnoyarsk
country: Russian Federation
facility: Synta Pharmaceuticals Investigational Site
city: Kursk
country: Russian Federation
facility: Synta Pharmaceuticals Investigational Site
city: Lipetsk
country: Russian Federation
facility: Synta Pharmaceuticals Investigational Site
city: Moscow
country: Russian Federation
facility: Synta Pharmaceuticals Investigational Site
city: Nizhny Novgorod
country: Russian Federation
facility: Synta Pharmaceuticals Investigational Site
city: Novosibirsk
country: Russian Federation
facility: Synta Pharmaceuticals Investigational Site
city: Omsk
country: Russian Federation
facility: Synta Pharmaceuticals Investigational Site
city: Orel
country: Russian Federation
facility: Synta Pharmaceuticals Investigational Site
city: Rostov-on-Don
country: Russian Federation
facility: Synta Pharmaceuticals Investigational Site
city: Samara
country: Russian Federation
facility: Synta Pharmaceuticals Investigational Site
city: Saransk
country: Russian Federation
facility: Synta Pharmaceuticals Investigational Site
city: Sochi
country: Russian Federation
facility: Synta Pharmaceuticals Investigational Site
city: St. Petersburg
country: Russian Federation
facility: Synta Pharmaceuticals Investigational Site
city: St. Petersburg
country: Russian Federation
facility: Synta Pharmaceuticals Investigational Site
city: St. Petersburg
country: Russian Federation
facility: Synta Pharmaceuticals Investigational Site
city: Stavropol
country: Russian Federation
facility: Synta Pharmaceuticals Investigational Site
city: Ufa
country: Russian Federation
facility: Synta Pharmaceuticals Investigational Site
city: Ufa
country: Russian Federation
facility: Synta Pharmaceuticals Investigational Site
city: Beograd
country: Serbia
facility: Clinical Centre of Serbia
state: Belgrade
city: Nis
country: Serbia
facility: Clinical Centre Nis
state: Nišavski okrug
city: Belgrade
country: Serbia
facility: Institute for Oncology and Radiology of Serbia
city: Sremska Kamenica
country: Serbia
facility: Institute for pulmonary diseases of Vojvodine
city: Kragujevac
country: Serbia
facility: Clinical Center Kragujevac
state: Šumadijski okrug
city: Golnik
country: Slovenia
facility: Univerzitetna klinika za pljucne bolesti in alergijo Golnik
city: Ljubljana
country: Slovenia
facility: Onkoloski institut Ljubljana
city: La Coruña
country: Spain
facility: Xerencia de Xestión Integrada A Coruña Hospital Teresa Herrera
state: A Coruña
city: Málaga
country: Spain
facility: Synta Pharmaceuticals Investigational Site
state: Andalucía
city: Oviedo
country: Spain
facility: Synta Pharmaceuticals Investigational Site
state: Asturias
city: Palma de Mallorca
country: Spain
facility: H. Son Llàtzer
state: Baleares
city: Mataró
country: Spain
facility: Hospital de Mataró, Consorci Sanitari del Maresme
state: Barcelona
city: Santander
country: Spain
facility: Synta Pharmaceuticals Investigational Site
state: Cantabria
city: San Sebastian
country: Spain
facility: Onkologikoa
state: Guipuzcoa
city: Badalona
country: Spain
facility: Hospital Universitari Germans Trias i Pujol
city: Barcelona
country: Spain
facility: H.U. Vall d'Hebrón
city: Barcelona
country: Spain
facility: Synta Pharmaceuticals Investigational Site
city: Córdoba
country: Spain
facility: H.U. Reina Sofía
city: Girona
country: Spain
facility: Synta Pharmaceuticals Investigational Site
city: Madrid
country: Spain
facility: Synta Pharmaceuticals Investigational Site
city: Madrid
country: Spain
facility: Hospital Universitario Ramón y Cajal
city: Madrid
country: Spain
facility: Synta Pharmaceuticals Investigational Site
city: Madrid
country: Spain
facility: F. Jiménez Diaz
city: Madrid
country: Spain
facility: Synta Pharmaceuticals Investigational Site
city: Madrid
country: Spain
facility: Hospital Madrid Norte Sanchinarro
city: Madrid
country: Spain
facility: Synta Pharmaceuticals Investigational Site
city: Sevilla
country: Spain
facility: Hospital Universitario Virgen del Rocío
city: Valencia
country: Spain
facility: Hospital Universitari i Politecnic La Fe
city: Cherkasy
country: Ukraine
facility: Synta Pharmaceuticals Investigational Site
city: Chernivtsi
country: Ukraine
facility: Synta Pharmaceuticals Investigational Site
city: Dnepropetrovsk
country: Ukraine
facility: Synta Pharmaceuticals Investigational Site
city: Donetsk
country: Ukraine
facility: Synta Pharmaceuticals Investigational Site
city: Donetsk
country: Ukraine
facility: Synta Pharmaceuticals Investigational Site
city: Ivano-Frankivsk
country: Ukraine
facility: Synta Pharmaceuticals Investigational Site
city: Kharkiv
country: Ukraine
facility: Synta Pharmaceuticals Investigative Site
city: Khmelnytskyi
country: Ukraine
facility: Synta Pharmaceuticals Investigational Site
city: Kirovohrad
country: Ukraine
facility: Synta Pharmaceuticals Investigational Site
city: Kryvyi Rih
country: Ukraine
facility: Synta Pharmaceuticals Investigational Site
city: Kyiv
country: Ukraine
facility: Synta Pharmaceuticals Investigational Site
city: Makiivka
country: Ukraine
facility: Synta Pharmaceuticals Investigational Site
city: Poltava
country: Ukraine
facility: Synta Pharmaceuticals Investigational Site
city: Simferopol
country: Ukraine
facility: Synta Pharmaceuticals Investigational Site
city: Sumy
country: Ukraine
facility: Synta Pharmaceuticals Investigational Site
city: Uzhhorod
country: Ukraine
facility: Synta Pharmaceuticals Investigational Site
city: Vinnytsia
country: Ukraine
facility: Synta Pharmaceuticals Investigational Site
city: Truro
country: United Kingdom
facility: Synta Pharmaceuticals Investigational Site
state: Cornwall
city: Shrewsbury
country: United Kingdom
facility: Synta Pharmaceuticals Investigational Site
state: Shropshire
city: Sutton
country: United Kingdom
facility: Synta Pharmaceuticals Investigational Site
state: Surrey
city: Swindon
country: United Kingdom
facility: Synta Pharmaceuticals Investigational Site
state: Wiltshire
city: Cardiff
country: United Kingdom
facility: Synta Pharmaceuticals Investigational Site
city: Edinburgh
country: United Kingdom
facility: Synta Pharmaceuticals Investigational Site
city: Leicester
country: United Kingdom
facility: Synta Pharmaceuticals Investigational Site
city: London
country: United Kingdom
facility: Synta Pharmaceuticals Investigational Site
city: London
country: United Kingdom
facility: Synta Pharmaceuticals Investigational Site
city: London
country: United Kingdom
facility: Synta Pharmaceuticals Investigational Site
city: Nottingham
country: United Kingdom
facility: Synta Pharmaceuticals Investigational Site
city: Southampton
country: United Kingdom
facility: Synta Pharmaceuticals Investigational Site
Study officials:
References: