Clinical trial NCT04634188: Role and Value of Inflammatory Markers in Brain Tumors : A Case Controlled Study
Official title: Role and Value of Inflammatory Markers in Brain Tumors : A Case Controlled Study
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Brain Tumor
Keywords: Brain Tumor, Inflammation, Procalcitonin, CRP, NLR
Lead sponsor: Universitas Sumatera Utara
Sponsor class: OTHER
First posted: 2020-11-18
Enrollment: 35
Sex: ALL
Minimum age (years): 18
Maximum age (years): 70
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: CASE_CONTROL
Time perspective: CROSS_SECTIONAL
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Samples were collected from patients at Haji Adam Malik Hospital in Medan, Sample collection began in March - September 2020

Brief summary: This study is a case controlled analytical study that analyzes the relationship between levels of inflammatory markers with the type of brain tumor. Samples of 35 people were then categorized according to the variables above and analyzing to measure its significance

Detailed description: This study is a case controlled analytical study to find the relationship between levels of inflammatory markers in patients with brain tumors. Samples were collected from patients at Haji Adam Malik Hospital in Medan, then the patient's blood serum was taken to be checked for these variables. Sample collection began in March - September 2020. The sample obtained was 35 people who met the inclusion and exclusion criteria.

Inclusion criteria:

1. Willing to be a sample
2. Complete medical records
3. Head scan and head contrast MRI have been performed to confirm the patient's diagnosis with a brain tumor

Exclusion criteria:

1. The patient's age is over 70 years
2. Patients with high comorbidities such as kidney failure, heart disease, diabetes, and others
3. Patients with a history of brain tumor surgery or previous brain tumor treatment

Samples were categorized based on demographic data (age and gender), then the samples were categorized based on the type of brain tumor suffered. Once categorized, the levels of inflammatory markers was examined. Specimens were taken from the patient's peripheral blood examination and analyzed in laboratorium. The results of these examinations are grouped on a nominal scale, and analyzed statistically.

Based on this analysis, it will be determined whether there is a significant relationship between levels of inflammatory markers in the incidence of brain tumors.

Eligibility criteria: Inclusion Criteria:

1. Willing to be a sample
2. Complete medical records
3. Head scan and head contrast MRI have been performed to confirm the patient's diagnosis with a brain tumor

Exclusion Criteria:

1. The patient's age is over 70 years
2. Patients with high comorbidities such as kidney failure, heart disease, diabetes, and others
3. Patients with a history of brain tumor surgery or previous brain tumor treatment

Primary outcomes:
measure: Value of Procalcitonin
timeFrame: February-April 2020
measure: Value of C-Reactive Protein
timeFrame: April- June 2020
measure: Value of Neutrophyl to Lymphocyte Ratio (NLR)
timeFrame: June- August 2020
Secondary outcomes:
measure: Demographic of samples
timeFrame: August- October 2020
Other outcomes:
Locations:
city: Medan
country: Indonesia
facility: Faculty of Medicine Universitas Sumatera Utara
state: North Sumatera
Study officials:
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