Clinical trial NCT05172388: Indoor Air Filtration and Young Adults Health Study
Official title: Cardiopulmonary Health Effects of Indoor Air Purification and Other Indoor Environmental Conditions Among Young Healthy Adults in Beijing, China
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Cardiopulmonary Diseases
Lead sponsor: Peking University
Sponsor class: OTHER
First posted: 2021-12-29
Enrollment: 81
Sex: ALL
Minimum age (years): 18
Maximum age (years): 28
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: CROSSOVER
Primary purpose: PREVENTION

Brief summary: This study aims to explore the cardiopulmonary health effects of indoor air purification and other indoor environmental conditions among young healthy college students in Beijing, China.

Detailed description: The present randomized, double-blind crossover study was conducted to investigate the cardiopulmonary health effects of air purification among 81 young healthy college students in Beijing, China. Real or sham purification was performed in the dormitories for 4 days, following a 15-day wash-out period in the intervals. During the study periods, the investigators collected indoor exposure levels of size-fractionated particulate matter (PM), black carbon (BC), noise, ozone, nitrogen dioxide, carbon dioxide, volatile organic compounds, temperature, relative humidity, illumination, and microorganism. Biological specimens (i.e., morning urine, fasting venous blood, exhaled breath condensate, and nasal mucus) were also collected and examined. Some important individual factors including demographical information (age, sex, height, weight, etc.), physical activity, sleep condition, mood and cognition, and food intake were also gathered using questionaire or anthropometric measurements, in order to control for the potential confounding effects. For further data analyses, air pollutants, noise, and other exposures would be controlled as confounders when addressing the health effects associated with air purification, and would also be used to explore their effects on cardiopulmonary health. The interaction effects of air pollutants, noise, and other exposures on cardiopulmonary health would also be explored.

Eligibility criteria: Inclusion Criteria:

* Living in Beijing for more than one consecutive years;
* College students between 18-28 years;

Exclusion Criteria:

* Current or past smokers;
* Body mass index (BMI) over 28.0 kg/m2.
* Alcohol addict;
* Having thoracic surgery history;
* History of diagnosed chronic disease;
* Hepatitis B / hepatitis C virus patient / carrier;
* Unwilling or unable to provide informed consent or cooperate with all research related procedures.

Primary outcomes:
measure: Changes in heart rate variability
timeFrame: Baseline and after the completion of intervention period (a 4-day real purifier intervention or a 4-day sham purifier intervention)
measure: Changes in blood pressure
timeFrame: Baseline and after the completion of intervention period (a 4-day real purifier intervention or a 4-day sham purifier intervention)
measure: Changes in pulmonary function
timeFrame: Baseline and after the completion of intervention period (a 4-day real purifier intervention or a 4-day sham purifier intervention)
Secondary outcomes:
measure: Changes in levels of airway inflammation
timeFrame: Baseline and after the completion of intervention period (a 4-day real purifier intervention or a 4-day sham purifier intervention)
measure: Changes in levels of C-reactive protein (CRP)
timeFrame: Baseline and after the completion of intervention period (a 4-day real purifier intervention or a 4-day sham purifier intervention)
measure: Changes in levels of 8-hydroxydeoxyguanosine (8-OHdG)
timeFrame: Baseline and after the completion of intervention period (a 4-day real purifier intervention or a 4-day sham purifier intervention)
measure: Changes in levels of sleep-related parameters
timeFrame: Baseline and after the completion of intervention period (a 4-day real purifier intervention or a 4-day sham purifier intervention)
measure: Changes in levels of sleep-breathing parameters
timeFrame: Baseline and after the completion of intervention period (a 4-day real purifier intervention or a 4-day sham purifier intervention)
measure: Changes in levels of cognitive function
timeFrame: Baseline and after the completion of intervention period (a 4-day real purifier intervention or a 4-day sham purifier intervention)
measure: Changes in levels of cognitive function-related biomarkers
timeFrame: Baseline and after the completion of intervention period (a 4-day real purifier intervention or a 4-day sham purifier intervention)
measure: Changes in levels of blood cell parameters
timeFrame: Baseline and after the completion of intervention period (a 4-day real purifier intervention or a 4-day sham purifier intervention)
measure: Changes in levels of systematic inflammation and oxidative stress indicators
timeFrame: Baseline and after the completion of intervention period (a 4-day real purifier intervention or a 4-day sham purifier intervention)
measure: Changes in levels of glucose metabolites in serum
timeFrame: Baseline and after the completion of intervention period (a 4-day real purifier intervention or a 4-day sham purifier intervention)
measure: Changes in levels of neurotransmitter metabolites in serum
timeFrame: Baseline and after the completion of intervention period (a 4-day real purifier intervention or a 4-day sham purifier intervention)
measure: Changes in levels of microbiomics in nasal mucus
timeFrame: Baseline and after the completion of intervention period (a 4-day real purifier intervention or a 4-day sham purifier intervention)
measure: Changes in levels of microbiomics in EBC
timeFrame: Baseline and after the completion of intervention period (a 4-day real purifier intervention or a 4-day sham purifier intervention)
measure: Changes in levels of pituitary-related hormones
timeFrame: Baseline and after the completion of intervention period (a 4-day real purifier intervention or a 4-day sham purifier intervention)
Other outcomes:
Locations:
city: Beijing
country: China
facility: Peking University
Study officials:
References: