Clinical trial NCT05797389: Effects of Graft Vascular Dimensions on Surgical and Functional Outcomes of Living Donor Kidney Transplantation
Official title: Effects of Graft Vascular Dimensions on Perioperative Surgical and Functional Outcomes of Living Donor Kidney Transplantation in Pediatrics and Adults: A Prospective Case Series
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Kidney Transplant; Complications
Keywords: kidney transplantation
renal transplantation
vascular dimensions
vascular parameters
Lead sponsor: Assiut University
Sponsor class: OTHER
First posted: 2023-04-04
Enrollment: 30
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: CASE_ONLY
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Pediatric and adult patients undergoing living donor kidney transplantation.

Brief summary: 1. Correlate the radiological and intraoperative measuring of the vascular dimensions,
2. Assess the effect of the vascular dimensions on the short-term surgical complications and
3. Assess the effect of the vascular dimensions on the primary graft function in pediatric and adults KTs.

Detailed description: Vascular complications after kidney transplantation (KT) are variably rare with an incidence of 3-15%. They are a significant and most serious part of surgical complications of KT. They may acutely result in graft loss during surgery or early in the perioperative period and may threaten patient's life. The most common forms of early vascular complications are haemorrhage, hematomas, arterial or venous thrombosis, arterial vasospasm, and arterial intimal dissection. In pediatric and adult KT, most studies addressing the vascular complications followed a common attitude of estimating the prevalence and management of these complications rather than studying the predisposing factors. Specifically, studying the normal and abnormal anatomy of the grafts has mainly been directed towards the number of graft vessels. However, there are many other vascular parameters that may potentially influence the outcome of vascular anastomosis and therefore the graft and patient outcomes. To the best of the investigators knowledge, the vascular dimensions of the renal and iliac vessels, such as the length, diameter and site of anastomosis to the iliac vessels have not been studied before so the investigators hypothesis that these dimensions can unequally affect the outcomes of surgery and early graft function in KTs. Hence, this study will be conducted to assess the effects of the vascular dimensions on the outcomes of surgery and primary graft function in pediatric versus adult living donor KT.

Eligibility criteria: Inclusion Criteria:

* Pediatric and adult patients undergoing living donor kidney transplantation.

Exclusion Criteria:

* Patients with acute graft rejection occurring within the first week of transplantation.
* Patients refusing participation in the study.

Primary outcomes:
measure: Mode of graft function defined by: 1- the time of start of diuresis post-transplantation.
timeFrame: one month post operative.
measure: 2- Rate of decline of the serum creatinine level.
timeFrame: one month post operative.
Secondary outcomes:
measure: The rate of vascular complications (intra- or perioperative).
timeFrame: one month post operative
measure: The rate of other surgical complications.
timeFrame: one month post operative
Other outcomes:
Locations:
Study officials:
References:
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