Clinical trial NCT06268171: Ultrasound Assessment of Rectus Femoris Cross-sectionnal Area Following Lung Transplantation
Official title: Ultrasound Assessment of Rectus Femoris Cross-sectionnal Area Following Lung Transplantation
Study type: OBSERVATIONAL
Overall status: ACTIVE_NOT_RECRUITING
Conditions: Lung Transplant
Physiotherapy
Sarcopenia
Lead sponsor: Hopital Foch
Sponsor class: OTHER
First posted: 2024-02-20
Enrollment: 42
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Lung transplant patients at Hôpital Foch

Brief summary: In France, the profile of patients receiving lung transplants has changed in recent years, mainly due to the advent of treatment for cystic fibrosis. This progress has led to an evolution in the patient profile, with an increase in cases of pulmonary fibrosis or COPD, and an increase in the average age of patients. In these older patients, sarcopenia, a condition characterized by loss of muscle mass, is a major concern, as it exacerbates morbidity and mortality.

After transplantation, patients are at risk of developing neuromyopathy due to their hospitalization in intensive care. There is currently no effective preventive treatment for this condition, underlining the need for early rehabilitation strategies. The combination of sarcopenia and neuromyopathy diminishes their functional capabilities on discharge from the ICU.

Muscle ultrasound, a simple, non-invasive technique, is already used to assess muscle function in intensive care patients. This study aims to evaluate the use of ultrasound to measure muscle loss in lung transplant patients, in particular by examining the rectus femoris muscle. Objectives include observing variations in the surface area of the rectus femoris muscle before and after transplantation, identifying factors influencing this variation, and exploring its relationship with post-transplant morbidity.

In summary, this study seeks to better understand muscle loss in lung transplant patients using ultrasound, in order to identify risk factors and guide the development of post-transplant rehabilitation strategies.


Eligibility criteria: Inclusion Criteria:

* Patient over the age of 18
* Patient registered on the lung transplant list at Hôpital Foch for a single or double-lung transplant
* Patient who did not object to inclusion in the study
* Patient affiliated to a French health insurance plan

Exclusion Criteria:

* Patient listed for a combined transplant (heart-lung, liver-lung, lung-kidney)
* Patient on national priority list (super-emergency)
* Pregnant or breast-feeding patient
* Patient under guardianship

Primary outcomes:
measure: Evaluation of the change at D7 in the cross-sectional area of the rectus femoris following lung transplantation
timeFrame: Baseline and Day 7
Secondary outcomes:
measure: Measure change in cross-sectional area of the rectus femoris at D7 according to LT pattern
timeFrame: Baseline and day 14
measure: Evaluate the relationship between length of stay in intensive care unit and variation in cross-sectional area of the rectus femoris at D7
timeFrame: Baseline and day 7
measure: Determine the relationship between cross-sectional area of the rectus femoris at D-1 and Body Mass Index
timeFrame: Baseline
Other outcomes:
Locations:
city: Suresnes
country: France
facility: Hopital Foch
state: Hauts de seine
Study officials:
affiliation: Hopital Foch
name: Matthieu Reffienna
role: PRINCIPAL_INVESTIGATOR
References: