Clinical trial NCT06946537: Nutritional Status and Patient Characteristics Upon Length of Stay, Clinical Outcome, and Survival in Older Hospitalized Patients
Official title: The Influence of Nutritional Status and Phenotypic Characteristics Upon Length of Stay, Clinical Outcome, and Survival in Hospitalized Patients
Study type: OBSERVATIONAL
Overall status: RECRUITING
Conditions: Geriatric
Malnutrition
Length of Stay
Keywords: Geriatric
Disease-related malnutrition
Physiology
Acute illness
Deep phenotyping
Nutritional status
Lead sponsor: Bispebjerg Hospital
Sponsor class: OTHER
First posted: 2025-04-27
Enrollment: 1500
Sex: ALL
Minimum age (years): 65
Standard ages: OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Patients acutely admitted at Bispebjerg Hospital

Brief summary: Disease-related malnutrition (DRM) describes undernutrition or imbalances in energy, protein, or other nutrient-needs, caused by a concomitant disease. Nutritional status plays a vital role in the fate of hospitalized patients, and DRM is associated with loss of function and decreased survival.

DRM is a common condition in patients with acute illnesses, approximately 30% among medical inpatients are malnourished when admitteed to the hospital, and rise higher among the older or critically ill. Physiologically malnutrition is associated with a) poorer tissue healing and restitution after severe disease, b) suppressed immune function and resistance towards infections, c) poorer metabolic defense towards critical disease, d) delayed and poorer progress of chronic diseases. In addition, inadequate nutrition is coupled to a prolonged hospital stay, resulting in more readmissions, and overall higher mortality in hospital patients. Yet, nutritional status of patients upon hospital admittance is seldom systematically assessed and the consequences of DRM in older acutely admitted patients still needs to be understood.

This project will provide a detailed description of nutritional, physiolgical, and biochemical status of 1500 acutely admitted patients. In relation, the study will investigate the relation between patient characteristics and disease progression. The obtained data will also be coupled to patient registers to investigate the link between length of hospital stay, readmissions and acute contact, and mortality.


Eligibility criteria: Inclusion Criteria:

* Acutely admitted adults aged 65 years and above.
* Be able to comply with the study information, as assessed by the research personnel.
* Be able to understand Danish.

Exclusion Criteria:

* \<24 hours admission
* Terminal illness in end stage of life
* Patients with temporary civil person registration number (CPR)

Primary outcomes:
measure: Length of Hospital Stay
timeFrame: From date of hospital admission untill discharge, assessed up to 2 months
Secondary outcomes:
measure: Readmission
timeFrame: Time to readmission 30 days from discharge
measure: Acute contact
timeFrame: Time to acute contact 30 days from discharge
measure: Mortality
timeFrame: Time to mortality 90 days from index admission
Other outcomes:
Locations:
city: Copenhagen
country: Denmark
facility: Bispebjerg Hospital
Study officials:
References: