louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT01771185: Metabolic Effects of Gastrointestinal Surgery in T2DM
Official title: Metabolic Effects of Duodenal-jejunal Bypass Surgery in Non Morbidly Obese Subjects With Type 2 Diabetes
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Type 2 Diabetes
Keywords: Diabetes
metabolic surgery
insulin resistance
Lead sponsor: University of Sao Paulo
Sponsor class: OTHER
First posted: 2013-01-18
Enrollment: 24
Sex: ALL
Minimum age (years): 20
Maximum age (years): 65
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: Gastric bypass surgery resolves type 2 diabetes mellitus (T2DM) without the need for diabetes therapy in \~80% of patients. Moreover, improvement in insulin sensitivity and glucose homeostasis occurs within days after surgery before significant weight loss is achieved. This observation has led to the notion that bypassing the upper gastrointestinal (GI) tract has specific therapeutic effects on insulin action and glucose metabolism. In fact, both surgical and endoscopic procedures that bypass the upper GI tract are currently being studied in human subjects. Recently, a new surgical technique, duodenal-jejunal bypass surgery (DJBS), has been developed specifically to treat T2DM. Data from preliminary studies have shown that DJBS results in glycemic control in 87% of overweight and obese patients with T2DM.These subjects will undergo metabolic studies at the University Hospital in Sao Paulo before and after their surgical procedure. Washington University investigators will: 1) provide technical support and guidance to the physicians performing the studies in Brazil, 2) process and analyze blood samples obtained from the study at the Washington University Center for Human Nutrition, and 3) be involved in analyzing the data and writing the final manuscripts. The effects of DJBS on the following clinical and metabolic parameters will be evaluated


Eligibility criteria: Inclusion Criteria:

* Uncontrolled diabetes ( A1c\>8%)
* Less than 10 years of history
* Not taking insulin
* Ages between 20 and 65 years old
* BMI between 26-34

Exclusion Criteria:

* previous abdominal surgery
* LADA
* Using insulin

Primary outcomes:
measure: Hb A1a
timeFrame: 24 mo
Secondary outcomes:
measure: Systolic and diastolic blood pressure control
timeFrame: 24 mo
measure: fasting glycemic control
timeFrame: 24 months
measure: Lipidic control
timeFrame: 24 months
Other outcomes:
Locations:
Study officials:
References:
Clinical trial NCT05793385: The Uncommon Complications of Meckel's Diverticulum
Official title: The Uncommon Complications of Meckel's Diverticulum: a Single Center Case Series Study and Literature Review
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: To Report the Rare Occurrence of Meckel's Diverticulum
Keywords: Meckel's diverticulum; isolated torsion; intussusception; acute abdomen; acute appendicitis
Lead sponsor: Haramaya Unversity
Sponsor class: OTHER
First posted: 2023-03-31
Enrollment: 4
Sex: ALL
Minimum age (years): 4
Maximum age (years): 33
Standard ages: CHILD
ADULT
Observational model: OTHER
Time perspective: RETROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: patients who presented with the diagnosis of acute abdomen

Brief summary: Acas series study was conducted on emergency acute abdomen patients who finally confirmed intraoperatively as Meckel's diverticulum with different complications. Simple perforation to isolated axial torsioned gangrene was observed. The patients signed consent for their cases to be published.

Detailed description: The study was aimed at reporting the rare complications of Meckel's diverticulum, which were diagnosed intraoperatively among acute abdomen patients presented to HFCSH. The patients had different complications ranging from simple isolated perforation to gangrenous Meckel's diverticulum. All of the patients gave their informed written and signed consent for publication.

Eligibility criteria: Inclusion Criteria:

* all patients diagnosed with complicated meckel's diverticulum

Exclusion Criteria:

* patients who didn't consent

Primary outcomes:
measure: Outcome upon discharge
timeFrame: 10 months
Secondary outcomes:
Other outcomes:
Locations:
city: Harar
country: Ethiopia
facility: Haramaya university
Study officials:
References:
Clinical trial NCT06976385: Clinical Impact of White Tea and Wheat Grass on Color Enhancement of White Spot Lesions
Official title: Clinical Impact of White Tea and Wheat Grass on Color Enhancement of White Spot Lesions
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: White Spot Lesions [Initial Caries] on Smooth Surface of Tooth
Lead sponsor: Al-Azhar University
Sponsor class: OTHER
First posted: 2025-05-16
Enrollment: 12
Sex: ALL
Minimum age (years): 15
Maximum age (years): 18
Standard ages: CHILD
ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The current study aimed to evaluate the color change potential of wheat grass and white tea on post orthodontic white spot lesions (WSLs). Materials and Methods: A total of 12 patients were divided into two main groups A1 and A2 according to type of treatment agent (n=6). The A1 group used 10% white tea solution while the A2 group used 10% wheat grass solution. Shade evaluation was conducted using VITA Easyshade V spectrophotometer. Baseline L a b values of WSLs were detected right after orthodontic bracket removal. Patients were requested to rinse with the treatment agent for 1 minute, twice per day. The mean L,a,b values were recorded after 1 month and after 3 months . ΔE values were calculated between baseline, 1 month and 3 months after the treatment agent application and subjected to statistical analysis using one way ANOVA with p\&gt;0.05. Also, Standardized photographs were taken at baseline, after 1 and 3 months. Each WSL was photographed twice with the 1st photograph taken of wet teeth and the 2nd one after prolonged air-drying in order to perform ICDAS II scoring.


Eligibility criteria: Inclusion Criteria:

1. Age range between 15-18 years.
2. Good oral hygiene
3. Obvious area of WSL was found around the fixed orthodontic brackets.
4. Included teeth should be free of any restorations

Exclusion Criteria:

- : 1. Cavitated enamel surface. 2. Presence of any restorations including the labial surface of the involved teeth.

3. Presence of any environmental or developmental enamel defect such as enamel hypoplasia, fluorosis, stains, and trauma sites on teeth before orthodontic treatment. 4. Allergy to tea and/or wheat

Primary outcomes:
measure: ΔE values were calculated
timeFrame: after 1 month and after 3 months
Secondary outcomes:
Other outcomes:
Locations:
city: Cairo
country: Egypt
facility: Al Azhar University
Study officials:
References:
Clinical trial NCT00312585: Acupuncture for the Prevention of Postdates Pregnancy
Official title: A Randomized Controlled Trial of Acupuncture to Prevent Postdates Pregnancy
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE2
Conditions: Pregnancy
Keywords: pregnancy
acupuncture
Lead sponsor: University of North Carolina, Chapel Hill
Sponsor class: OTHER
First posted: 2006-04-10
Enrollment: 89
Sex: FEMALE
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The purpose of this study is to assess if acupuncture can shorten the time to delivery for women who are experiencing their first, full-term pregnancy.

Detailed description: There are certain medical conditions that can complicate pregnancies after 40 weeks gestation. However, it is not always safe or easy to put these women into labor. Acupuncture has been used in Asia for hundreds of years to induce contractions and begin the labor process. Acupuncture is not typically used in the United States to induce labor, however. The purpose of this study is to determine whether a series of up to five acupuncture treatments can prevent postdates pregnancy.

Eligibility criteria: Inclusion Criteria:

* first, full-term pregnancy
* 38-41 weeks gestation
* English or Spanish speaking
* Bishop score of 7 or less

Exclusion Criteria:

* uncertain pregnancy dating
* transportation difficulties
* previous inability to tolerate acupuncture
* age less than 18

Primary outcomes:
measure: prevention of inpatient induction of labor
Secondary outcomes:
measure: rate of cesarean delivery
measure: rates of chorioamnionitis
measure: length of maternal hospital stay
measure: rates of assisted delivery
measure: neonatal outcomes
Other outcomes:
Locations:
city: Chapel Hill
country: United States
facility: UNC-Chapel Hill Family Medicine Center
state: North Carolina
Study officials:
affiliation: UNC-Chapel Hill Department of Ob/Gyn
name: Teresa Harper, MD
role: PRINCIPAL_INVESTIGATOR
References:
citation: Harper TC, Coeytaux RR, Chen W, Campbell K, Kaufman JS, Moise KJ, Thorp JM. A randomized controlled trial of acupuncture for initiation of labor in nulliparous women. J Matern Fetal Neonatal Med. 2006 Aug;19(8):465-70. doi: 10.1080/14767050600730740.
Clinical trial NCT01045785: Investigation of Platelet Function and Aspirin Resistance in Chronic Dialysis Patient
Official title: Investigation of Platelet Function and Aspirin Resistance in Chronic Dialysis Patient
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: End Stage Renal Disease
Keywords: aspirin resistance, platelet function assay, dialysis, end stage renal disease
Lead sponsor: National Taiwan University Hospital
Sponsor class: OTHER
First posted: 2010-01-11
Enrollment: 300
Sex: ALL
Minimum age (years): 20
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: COHORT
Time perspective: CROSS_SECTIONAL
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Dialysis patients which follow-up at least monthly at National Taiwan University Hospital

Brief summary: The purpose of this study is to determine whether aspirin resistance has impact on cardiovascular event in dialysis patient.

Detailed description: Dialysis patient inevitably suffered from uremic bleeding although improvement of dialysis care in the past decades. Physicians used to check bleeding time as a surrogate marker for uremic bleeding. However, bleeding time isn't accurate and as well known, is poorly correlated with clinical bleeding such as surgical bleeding. Platelet function assay (PFA) is a newly developed method to measure platelet aggregation in vitro and is validated in many sorts of platelet disorders. Recently, PFA was also used to evaluate aspirin responsiveness in patients who had taken aspirin. Our study is aim to investigate uremic thrombocytopathy via PFA of dialysis patient in Taiwan. Furthermore, we will study aspirin resistance in dialysis patient.

Eligibility criteria: Inclusion Criteria:

* dialysis \>3 months
* Hb\>10 g/dl \& Plt \> 10000

Exclusion Criteria:

* using medication which interfere PFA except aspirin
* terminal disease such as malignancy
* active vasculitis

Primary outcomes:
measure: cardiovascular event, bleeding event,and thrombosis
timeFrame: 1 year
Secondary outcomes:
Other outcomes:
Locations:
city: Taipei
country: Taiwan
facility: National Taiwan University Hospital
Study officials:
affiliation: National Taiwan University Hospital
name: Jenqwen Huang, MD
role: PRINCIPAL_INVESTIGATOR
References:
citation: Bilgin AU, Karadogan I, Artac M, Kizilors A, Bligin R, Undar L. Hemodialysis shortens long in vitro closure times as measured by the PFA-100. Med Sci Monit. 2007 Mar;13(3):CR141-5.
Clinical trial NCT00753285: Renal Denervation in Patients With Refractory Hypertension
Official title: Renal Denervation in Patients With Refractory Hypertension
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Hypertension
Lead sponsor: Medtronic Vascular
Sponsor class: INDUSTRY
First posted: 2008-09-16
Enrollment: 35
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: TREATMENT

Brief summary: The purpose of this study is to investigate the clinical utility of renal denervation for the treatment of refractory hypertension.


Eligibility criteria: Inclusion Criteria:

* Systolic blood pressure of 160 mmHg or greater
* On 3 or more antihypertensive medications
* eGFR \>= 45 mL/min

Exclusion Criteria:

* Renal artery abnormalities
* Known secondary hypertension attributable to a cause other than sleep apnea
* MI, angina, CVA within 6 months
* Type 1 diabetes
* Others

Primary outcomes:
measure: Safety - complications associated with delivery and/or use of the Ardian Catheter, adverse renal events, electrolyte disturbances, hemodynamic events.
timeFrame: Through 3 years
Secondary outcomes:
measure: Physiologic response to renal denervation (e.g., blood pressure reduction)
timeFrame: Through 3 years
Other outcomes:
Locations:
city: Springfield
country: United States
facility: Prairie Heart Institute
state: Illinois
city: Minneapolis
country: United States
facility: Hennepin County Medical Center
state: Minnesota
city: Cleveland
country: United States
facility: MetroHealth Medical Center
state: Ohio
Study officials:
affiliation: Monash University and the Alfred Hospital
name: Henry Krum, PhD
role: PRINCIPAL_INVESTIGATOR
References:
citation: Krum H, Schlaich MP, Sobotka PA, Bohm M, Mahfoud F, Rocha-Singh K, Katholi R, Esler MD. Percutaneous renal denervation in patients with treatment-resistant hypertension: final 3-year report of the Symplicity HTN-1 study. Lancet. 2014 Feb 15;383(9917):622-9. doi: 10.1016/S0140-6736(13)62192-3. Epub 2013 Nov 7.
Clinical trial NCT01955785: Respiratory Treatment of Patients With Moderate and Severe Traumatic Brain Injury
Official title: Respiratory Treatment of Patients With Moderate and Severe Traumatic Brain Injury: A Randomised Comparison of Pressure Controlled Ventilation and Pressure Regulated Volume Controlled Ventilation
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Traumatic Brain Injury
Keywords: Traumatic brain injury
Intracranial pressure
Ventilation
Respiratory therapy
Lead sponsor: Norwegian University of Science and Technology
Sponsor class: OTHER
First posted: 2013-10-08
Enrollment: 11
Sex: ALL
Minimum age (years): 16
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: CROSSOVER
Primary purpose: TREATMENT

Brief summary: Intracranial pressure (ICP) in patients with traumatic brain injury (TBI) is influenced by several factors of which one is arterial CO2 tension. Patient with TBI are often sedated and mechanically ventilated in order to secure a stable PaCO2. This study compares two ventilation modus; Pressure Controlled Ventilation (PC) and Pressure Regulated Volume Controlled ventilation (PRVC) in order to observe which of the two ventilation strategies results in a more stable ICP and arterial CO2 pressure (PaCO2).


Eligibility criteria: Inclusion Criteria:

* Informed consent obtained from the patients next-of-kin.
* moderate or severe TBI according to Head Injury Severity Scale (Glasgow Coma Scale (GCS) score 3-13).
* treated at the neurosurgical ICU or the main ICU at St Olav University Hospital.
* intubated and receiving controlled mechanical ventilation.
* continuous measurement of ICP with either an intraventricular or an intraparenchymal pressure monitor device.
* sedation to a level of sedation corresponding to MAAS (Motor Activity Assessment Score) 0 or 1 with continuous intravenous infusions of midazolam/propofol and morphine/fentanyl/remifentanil14.

Exclusion Criteria:

* Pregnancy
* ICP above 25 mmHg
* ongoing cerebral anti edema therapy corresponding to Step III at St Olav University Hospital therapy guideline
* continuous external drainage of cerebrospinal fluid (CSF)
* Clinical pulmonary condition prohibiting changes in respiratory therapy

Primary outcomes:
measure: ICP
timeFrame: Two hours
Secondary outcomes:
measure: PaCO2
timeFrame: Two hours
Other outcomes:
Locations:
city: Trondheim
country: Norway
facility: Dept Intensive Care Medicine, St Olavs University Hospital
Study officials:
affiliation: National Taiwan Normal University
name: Pål Klepstad, MD PhD
role: PRINCIPAL_INVESTIGATOR
References:
citation: Schirmer-Mikalsen K, Vik A, Skogvoll E, Moen KG, Solheim O, Klepstad P. Intracranial Pressure During Pressure Control and Pressure-Regulated Volume Control Ventilation in Patients with Traumatic Brain Injury: A Randomized Crossover trial. Neurocrit Care. 2016 Jun;24(3):332-41. doi: 10.1007/s12028-015-0208-8.
Clinical trial NCT00979485: Microparticles in Pediatric Inflammatory Disease
Official title: Microparticles in Pediatric Inflammatory Bowel Disease
Study type: OBSERVATIONAL
Overall status: TERMINATED
Conditions: Crohn's Disease
Ulcerative Colitis
Keywords: Pediatric IBD
Microparticles
Lead sponsor: Indiana University
Sponsor class: OTHER
First posted: 2009-09-18
Enrollment: 40
Sex: ALL
Minimum age (years): 8
Maximum age (years): 17
Standard ages: CHILD
Accepts healthy volunteers: yes
Observational model: CASE_CONTROL
Time perspective: CROSS_SECTIONAL
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Pediatric GI clinic at Riley Hospital Pediatric well child clinic at Riley Hospital

Brief summary: The purpose of this study is to provide data correlating levels of microparticles that circulate in the blood and disease activity in children with inflammatory bowel disease (IBD). The hypothesis is that circulating microparticles will be higher in children with active IBD, show inflammatory activity, and will be low in patients in remission as well as in healthy controls.

Detailed description: Once the response of microparticles to inflammation is defined in this patient population, the microparticles can be used as biomarkers of disease activity and could potentially use microparticles as targets of therapeutic agents.

This cross sectional study will enroll 15 Crohn's patients (5 inactive, 5 mild, 5 moderate-severe disease based on the pediatric Crohn's disease activity index), 15 Ulcerative Colitis patients (5 inactive, 5 mild, 5 moderate-severe disease based on the pediatric ulcerative colitis activity index), and 10 healthy controls.

Eligibility criteria: Inclusion Criteria:

* Children with IBD based on endoscopic, histologic, radiologic, or laboratory data
* Ages between 8 and 17 years old

Exclusion Criteria:

* Anyone with a concurrent illness since infection can affect microparticle levels

Primary outcomes:
Secondary outcomes:
Other outcomes:
Locations:
city: Indianapolis
country: United States
facility: Indiana Unversity, Riley Hospital for Children
state: Indiana
Study officials:
affiliation: Indiana University
name: Steven ' Steiner, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT02289885: FAST Examination During Emergency Practice
Official title: Knowledge, Attitude and Practice About Focused Assessment With Sonography in Trauma Among Paramedics. Randomized Crossover Manikin Trial
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Trauma
Ultrasonography
Keywords: trauma
examination
knowledge
paramedic
Lead sponsor: International Institute of Rescue Research and Education
Sponsor class: OTHER
First posted: 2014-11-13
Enrollment: 100
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: CROSSOVER
Primary purpose: TREATMENT

Brief summary: The study evaluates the knowledge, attitude and practice about Focused Assessment with Sonography in Trauma among emergency medicine practitioners in Poland.


Eligibility criteria: Inclusion Criteria:

* Paramedics currently practicing in a Polish emergency department units and emergency medical services
* Age ≥ 18 years

Exclusion Criteria:

* Inability to participate in all aspects of the study prior to study begin

Primary outcomes:
measure: Tests of Knowledge of the FAST Examination
timeFrame: 1 day
Secondary outcomes:
measure: FAST Performance Test
timeFrame: 1 day
measure: Window acquisition time
timeFrame: 1 day
measure: Window quality
timeFrame: 1 day
measure: Diagnostic accuracy
timeFrame: 1 day
Other outcomes:
Locations:
city: Warsaw
country: Poland
facility: International Institute of Rescue Research and Education
Study officials:
affiliation: Institute of Cardiology
name: Lukasz Szarpak
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT05894785: External Cephalic Version (ECV) for Twins With Non-vertex Presenting Twin
Official title: External Cephalic Version (ECV) for Twins With Non-vertex Presenting Twin
Study type: INTERVENTIONAL
Overall status: RECRUITING
Phase: NA
Conditions: Twin Pregnancy With Antenatal Problem
Lead sponsor: Shaare Zedek Medical Center
Sponsor class: OTHER
First posted: 2023-06-08
Enrollment: 30
Sex: FEMALE
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: TREATMENT

Brief summary: In this study, women with a twin pregnancy with the presenting twin in a non-vertex(head) presenting twin undergo an external cephalic version.


Eligibility criteria: Inclusion Criteria:

* 18 years old or older multiparous no previous cesarean delivery (CD) a non-vertex presenting twin in a term (37 weeks gestation and onwards) dichorionic diamniotic twin pregnancy

Exclusion Criteria:

* contraindication for a vaginal delivery nulliparous monochorionic diamniotic pregnancy

Primary outcomes:
measure: Success rates of ECV
timeFrame: 1 day
Secondary outcomes:
measure: Maternal and fetal morbidities
timeFrame: up to 7 days from enrollment
Other outcomes:
Locations:
city: Jerusalem
country: Israel
facility: Shaare Zedek Medical Center
Study officials:
References:
Clinical trial NCT01723085: Anti-Mullerian Hormone Levels Before and After an Open Myomectomy
Official title: Anti-Mullerian Hormone Levels Variations Following an Open Myomectomy
Study type: OBSERVATIONAL
Overall status: TERMINATED
Conditions: Anti-Mullerian Hormone
Keywords: Anti-Mullerian hormone
Myomectomy
Laparotomy
Lead sponsor: Clinique Ovo
Sponsor class: INDUSTRY
First posted: 2012-11-07
Enrollment: 21
Sex: FEMALE
Minimum age (years): 18
Maximum age (years): 42
Standard ages: ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Women 18 to 42 tears old Indication for myomectomy by laparotomy

Brief summary: Anti-Mullerian hormone (AMH) is a marker for ovarian reserve. It is well known that ovarian surgery for endometriosis lowers Anti-Mullerian hormone, but little is known for other surgeries. We seek to investigate the hormone variations before and after an open myomectomy.

Hypothesis: Anti-Mullerian hormone levels drop following surgery but return to normal levels in a few months


Eligibility criteria: Inclusion Criteria:

* 18 to 42 years old
* Requiring open myomectomy for any indication

Exclusion Criteria:

* Incapable of informed consent
* Use of hormonal contraception or Gonadotropin-releasing hormone agonists in the past 3 months
* Woman over 42 years old
* Post-menopause women
* Positive B-human chorionic gonadotropin the day of surgery
* Ovarian surgery (at the same time)
* Pre-operative AMH below 0.3 ng/mL

Primary outcomes:
measure: Anti-Mullerian Hormone levels variation
timeFrame: 6 months
Secondary outcomes:
Other outcomes:
Locations:
city: Montreal
country: Canada
facility: Hopital Saint-Luc
state: Quebec
Study officials:
affiliation: Centre hospitalier de l'Université de Montréal (CHUM)
name: Eric Himaya, MD
role: PRINCIPAL_INVESTIGATOR
References: