Clinical trial NCT02059980: Developing Effective Response Inhibition Training for Symptom Relief in OCD and Trichotillomania
Official title: Developing Effective Response Inhibition Training for Symptom Relief in Obsessive-Compulsive and Related Disorders and Trichotillomania
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Obsessive Compulsive Disorder
Trichotillomania
Keywords: OCD
Trichotillomania
Response inhibition
Cognitive training
Lead sponsor: University of Wisconsin, Milwaukee
Sponsor class: OTHER
Collaborators: name: National Institute of Mental Health (NIMH)
First posted: 2014-02-11
Enrollment: 45
Sex: ALL
Minimum age (years): 18
Maximum age (years): 60
Standard ages: ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: Obsessive-compulsive disorder (OCD) and its related disorders (e.g., trichotillomania) are characterized by the marked difficulty in inhibiting unwanted or inappropriate responses. There is compelling evidence that poor response inhibition is a core cognitive feature of OCD and its related disorders, but no effective intervention exists that directly attempts to address this problematic cognitive deficiency. This study will examine the feasibility and clinical utility of a computerized cognitive training program designed to improve response inhibition among individuals diagnosed with OCD or trichotillomania.This training program offers systematic practice of response inhibition in the form of a 40-level computer game. Individuals with these conditions will be randomized to either 8 sessions of (a) computerized response inhibition training (RIT) or (b) placebo computer training (PLT). We hypothesize that RIT will outperform PLT in improving response inhibition capabilities and reducing relevant clinical symptoms. In sum, this project is expected to generate important knowledge to guide the development of effective computer-based treatment approaches that may help reduce critical problems of existing treatments such as suboptimal patient retention and treatment under-utilization, thereby improving overall treatment response rates among individuals suffering from OCD and related conditions.


Eligibility criteria: Inclusion Criteria:

* Principal diagnosis of obsessive-compulsive disorder or trichotillomania

Exclusion Criteria:

* Current substance use problems
* Current/Past Psychotic disorder, bipolar disorder, or schizophrenia
* Attention deficit/hyperactivity disorder or tic disorder
* Severe depressive symptoms
* Current psychotherapy
* Current suicidality
* Estimated intellectual functioning \< 80
* Lack of response inhibition deficits on a stop-signal task

Primary outcomes:
measure: Composite Score of Yale-Brown Obsessive-Compulsive Scale (Y-BOCS) and National Institute of Mental Health (NIMH)
timeFrame: Baseline, Week 4, and Week 8
measure: Stop Signal Reaction Time
timeFrame: Baseline, Week 4, and Week 8
Secondary outcomes:
measure: Clinical Global Impression Severity and Improvement
timeFrame: Baseline, Week 4, and Week 8
measure: Commission Errors on the Go/No-go Task.
timeFrame: Baseline, Week 4, and Week 8
Other outcomes:
Locations:
city: Milwaukee
country: United States
facility: Psychology Clinic, University of Wisconsin-Milwaukee
state: Wisconsin
Study officials:
affiliation: University of Wisconsin, Milwaukee
name: Han Joo Lee, Ph.D.
role: PRINCIPAL_INVESTIGATOR
References: