Clinical trial NCT04211207: Evaluation of the Heart's Respiratory Quotient as Predictive Value After Extra-hospital Cardiac Arrest
Official title: Evaluation of the Heart's Respiratory Quotient as Predictive Value After Extra-hospital
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Cardiac Arrest
Keywords: Heart's respiratory quotient
Cardiac Arrest
Non-invasive monitoring
Poor prognosis
Lead sponsor: University Hospital, Grenoble
Sponsor class: OTHER
First posted: 2019-12-26
Enrollment: 40
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: CASE_ONLY
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: Patients presenting to the ICU for cardiac arrest will be recruited into the study according the inclusion /non inclusion criteria, The patient should be inclued according the investigtor decision, and the non-opposition of patient's relatives was asked as soon as possible. the eligible patient will be enrolled in the study and post cardiac arrest standard care was applied, Implementation of the calorimetry module for the constants collection. data collection was during the first 24 hours.

When the patient wakes up: information and collection of his non-opposition was asked. The vital status will be collected at 30 day and neurological prognosis evaluation defined by the CPC scorewill be collected at 90 ± 7j by telephone contact.

Brief summary: It has been shown that elevation of the heart's respiratory quotient after cardiac surgery is predictive of the complications occurrence. In addition, a high heart's respiratory quotient is predictive of anaerobic metabolism after cardiac surgery. In the wake of cardiorespiratory arrest, the presence of anaerobic metabolism reflected by hyperlactatemia is an important prognostic factor. However, this monitoring is invasive and discontinuous. The hypothesis of the study is to show that a rise in the respiratory quotient by a non-invasive monitoring is a factor of poor prognosis in the wake of a Cardiac Arrest.


Eligibility criteria: Inclusion Criteria:

* Adult \>18 years
* Admission to intensive care unit after a non-hospital cardiopulmonary arrest.
* Resumption of spontaneous cardiac activity.
* Non-opposition of the patient or his relatives

Exclusion Criteria:

* Pregnancy
* Prior neurological impairment
* Persons deprived of their liberty by a judicial proceeding, or administrative decision.

Primary outcomes:
measure: Heart's respiratory value at H6 post intensive care unit admission to predict mortality
timeFrame: At 6 hours post intensive care unit admission
Secondary outcomes:
measure: Heart's respiratory value at intensive care unit admission to predict mortality
timeFrame: At admission of intensive care unit
measure: Heart's respiratory value at H12 post intensive care unit admission to predict mortality
timeFrame: At 12 hours post intensive care unit admission
measure: Heart's respiratory value at H24 post intensive care unit admission to predict mortality
timeFrame: At 24 hours post intensive care unit admission
measure: Heart's respiratory value at intensive care unit admission to predict neurological prognosis
timeFrame: At admission of intensive care unit
measure: Heart's respiratory value at H6 post intensive care unit admission to predict neurological prognosis
timeFrame: At 6 hours post intensive care unit admission
measure: Heart's respiratory value at H12 post intensive care unit admission to predict neurological prognosis
timeFrame: At 12 hours post intensive care unit admission
measure: Heart's respiratory value at H24 post intensive care unit admission to predict neurological prognosis
timeFrame: At 24 hours post intensive care unit admission
measure: metabolic parameters ( lactate, Oxygen consummation, carbon dioxide production and central venous oxygen saturation) to predict mortality at intensive care unit admission
timeFrame: At admission of intensive care unit
measure: metabolic parameters ( lactate, Oxygen consummation, carbon dioxide production and central venous oxygen saturation) to predict mortality at H6 post intensive care unit admission
timeFrame: At 6 hours post intensive care unit admission
measure: Metabolic parameters ( lactate, Oxygen consummation, carbon dioxide production and central venous oxygen saturation) to predict mortality at H12 post intensive care unit admission
timeFrame: At 12 hours post intensive care unit admission
measure: Metabolic parameters ( lactate, Oxygen consummation, carbon dioxide production and central venous oxygen saturation) to predict mortality at H24 post intensive care unit admission
timeFrame: At 24 hours post intensive care unit admission
measure: Metabolic parameters ( lactate, Oxygen consummation, carbon dioxide production and central venous oxygen saturation) to predict neurological prognosis at intensive care unit admission
timeFrame: At admission of intensive care unit
measure: Metabolic parameters ( lactate, Oxygen consummation, carbon dioxide production and central venous oxygen saturation) to predict neurological prognosis at H6 post intensive care unit admission
timeFrame: At 6 hours post intensive care unit admission
measure: Metabolic parameters ( lactate, Oxygen consummation, carbon dioxide production and central venous oxygen saturation) to predict neurological prognosis at H12 post intensive care unit admission
timeFrame: At 12 hours post intensive care unit admission
measure: Metabolic parameters ( lactate, Oxygen consummation, carbon dioxide production and central venous oxygen saturation) to predict neurological prognosis at H24 post intensive care unit admission
timeFrame: At 24 hours post intensive care unit admission
measure: Cardiac arrest circumstances following Utstein-style guidelines according mortality
timeFrame: At admission of intensive care unit
measure: Cardiac arrest circumstances following Utstein-style guidelines according neurological prognosis
timeFrame: At admission of intensive care unit
measure: Vital status at day 30
timeFrame: At 30 Days post intensive car unit admission
measure: Cerebral performance category (CPC) score at day 90
timeFrame: At 90 Days post intensive car unit admission
Other outcomes:
Locations:
city: Grenoble
country: France
facility: Chu Grenoble Alpes
Study officials:
References:
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