Clinical trial NCT06755385: Pilot Study on the Value of Bedside Pleuropulmonary Ultrasound in Patients With Sickle Cell Disease Presenting With Vaso-occlusive Crisis
Official title: Pilot Study on the Value of Bedside Pleuropulmonary Ultrasound in Patients With Sickle Cell Disease Presenting With Vaso-occlusive Crisis.
Study type: OBSERVATIONAL
Overall status: NOT_YET_RECRUITING
Conditions: Sickle Cell Disease
Keywords: Sickle cell disease
Pulmonary anomalies
Vaso-occlusive crisis
Acute chest syndrom
Pleuropulmonary ultrasound
Lead sponsor: University Hospital, Grenoble
Sponsor class: OTHER
First posted: 2025-01-01
Enrollment: 25
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Patients with sickle cell disease hospitalized in the internal medicine department of Grenoble University Hospital for vasoocclusive crisis.

Brief summary: Describe the proportion of patients with major sickle cell syndrome in vaso-occlusive crisis presenting at least one pleuropulmonary ultrasound abnormality during one of the ultrasounds performed at D0, between D2 and D5 during hospitalization and at D-1 of discharge.

We hypothesize that pleuropulmonary ultrasound will make it possible to detect the serious complications associated with vaso-occlusive crises in patients with major sickle cell syndrome earlier and more reliably, in departments where ultrasound tools are still underdeveloped, while avoiding the need for more conventional radiology examinations that cause radiation in multi-hospitalized patients.


Eligibility criteria: Inclusion Criteria:

* Patient agreeing to participate in the study
* Patient with sickle-cell disease consulted to the emergency department or hospitalized in a conventional internal medicine department for a clinical picture of severe vaso-occlusive crisis (CVO) requiring hospitalization.
* Hospitalization in the internal medicine department
* Possible re-inclusion in the event of a subsequent episode of severe CVO

Exclusion Criteria:

* Subject under guardianship or subject deprived of freedom.
* Primary acute chest syndrom (not following a crisis)
* Pulmonary pathologies interfering with pleuro-pulmonary echo analysis: pneumonectomy, pulmonary fibrosis.

Primary outcomes:
measure: Description of the proportion of patients with sickle cell disease in vasoocclusive crisis presenting at least one pleuropulmonary ultrasound abnormality at D0, between D2 and D5 during hospitalization and at D-1 of discharge.
timeFrame: 30 days
Secondary outcomes:
measure: Evaluate the association between the ultrasound image and the clinical picture
timeFrame: 30 days
measure: Evaluate the association between the ultrasound image detected and the occurrence of acute chest syndrom.
timeFrame: 30 days
measure: Evaluate the association between the ultrasound image detected and the severity of the acute chest syndrom
timeFrame: 30 days
measure: Describe the evolution of abnormalities between visits at D0, between D2 and D5 (V1 and V2) during hospitalization and at D-1 of discharge, and their association with clinical evolution
timeFrame: 30 days
measure: Assess the prognostic value of discharge pleuropulmonary ultrasound in relation to re-hospitalization, occurrence of acute chest syndrom or early mortality (within 30 days)
timeFrame: 30 days
Other outcomes:
Locations:
Study officials:
References:
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