Clinical trial NCT02179307: Individual Response to Different Volumes of Resistance Training
Official title: Determinants of Intra-individual Variation in Adaptability to Resistance Training of Different Volumes
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Healthy
Keywords: muscle hypertrophy
strength
resistance training
exercise
physical fitness
health
physical conditioning
Lead sponsor: Inland Norway University of Applied Sciences
Sponsor class: OTHER
Collaborators: name: Sykehuset Innlandet HF
name: Revmatismesykehuset AS
First posted: 2014-07-01
Enrollment: 42
Sex: ALL
Minimum age (years): 18
Maximum age (years): 40
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: BASIC_SCIENCE

Brief summary: The literature is not clear as to which training volume to employ during initial phases of resistance training programs to ensure optimal muscular adaptations. The purpose of this study is therefore to compare effects of strength training with low versus moderate volume on muscular function and hypertrophy in previously untrained, healthy individuals. Furthermore, the investigators will relate individual variation in responses to proxy markers of individual training state, such as baseline muscular function and muscle fiber type.

The study will include 25 women and 25 men and will consist of a 12-week resistance training protocol. Each study participant will act as their own control, performing both the low- (1-set) and the moderate-volume (3-sets) protocol, allocated to either the dominant or non-dominant leg, in a stratified and randomized fashion.

Primary outcome measures are thigh muscle cross section area and unilateral knee extension strength. Additionally, muscle fiber type composition will be evaluated as well as additional parameters of muscular function.

The primary hypothesis is that low-volume protocols will be beneficial for individuals with glycolytic muscle phenotypes, whereas the opposite will be true for individuals with more aerobic phenotypes.


Eligibility criteria: Inclusion Criteria:

* Healthy
* Non-smoking
* Able to tolerate resistance exercise training

Exclusion Criteria:

* Presence or history of cardiovascular, metabolic, endocrine or neuromuscular disease
* Diagnosed mental health disorder
* Intolerance to local anesthetic
* No experience with exercise training
* Performing regular resistance training (more than 1 session per week during last 12 months)
* Impaired strength/ neuromuscular function due to previous injury
* Recurrent pain in lower back, knee or shoulders
* Taking prescribed medication that may affect outcome of training intervention

Primary outcomes:
measure: Thigh muscle cross-sectional area
timeFrame: Week 0 (baseline) and 12 (post training intervention)
measure: Unilateral knee-extension isometric strength
timeFrame: Week 0 (baseline), 2, 5, 9 (during intervention) and 12 (after training intervention)
Secondary outcomes:
measure: Muscle strength
timeFrame: Week 0 (baseline), 2, 5, 9 (during intervention) and 12 (after training intervention)
measure: Knee extensors and flexors force-velocity relationship
timeFrame: Week 0 (baseline), 2, 5, 9 (during intervention) and 12 (after training intervention)
measure: Blood hormonal profiles
timeFrame: Week 0 (baseline), 2 and 12 (post training intervention)
measure: Muscle fiber cross-sectional area
timeFrame: Week 0 (baseline), 2 and 12 (post training intervention)
measure: Protein expression
timeFrame: Week 0 (baseline), 2 and 12 (post training intervention)
measure: Gene expression
timeFrame: Week 0 (baseline), 2 and 12 (post training intervention)
Other outcomes:
measure: Body composition changes
timeFrame: Week 0 (baseline) and 12 (post training intervention)
measure: Habitual physical activity
timeFrame: Week 0
measure: Daily nutrient intake
timeFrame: Week 6
Locations:
city: Lillehammer
country: Norway
facility: Lillehammer University College
Study officials:
affiliation: Inland Norway University of Applied Sciences
name: Stian Ellefsen, PhD
role: PRINCIPAL_INVESTIGATOR
References: