Clinical trial NCT06886880: Endoscopic Findings in Patients With Upper GIT Bleeding
Official title: Endoscopic Findings in Patients With Upper GIT Bleeding in Assiut University Hospital
Study type: OBSERVATIONAL
Overall status: NOT_YET_RECRUITING
Conditions: GIT - Gastrointestinal Tract Hemorrhage
Lead sponsor: Assiut University
Sponsor class: OTHER
First posted: 2025-03-20
Enrollment: 100
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: 2.4.1- Type of the study: Prospective cross-sectional study .

2.4. 2- Study Setting: Assiut University Hospital , Alraghy Hospital, Endoscopy centre.

2.4. 3- Study subjects:

1. Inclusion criteria:

   Adult patients present with upper GIT bleeding of both gender older than 18 years old
2. Exclusion criteria:

   1. Patients younger than 18
   2. Pregnant women
   3. patients with end stage disease that not fit for endoscopic intervention

Brief summary: This study aims to identify the causes of upper gastrointestinal bleeding through comprehensive evaluation via upper endoscopy in Assiut University Hospital and contribute valuable insights into effective management strategies.

Detailed description: Upper gastrointestinal bleeding (UGIB) is a critical medical situation that arises when there is bleeding proximal to the ligament of Treitz \[1\]. This condition is a leading cause of morbidity and mortality, with death rates ranging from 5-14% and increasing to over 40% in patients with liver disease\[2\] Symptoms of UGIB may include anemia, hematemesis, melena, or hematochezia \[3\].

Neoplasms, arteriovenous malformations, esophageal varices, gastric ulcers, gastric erosions, duodenal ulcers, reflux esophagitis, Mallory-Weiss tears, and fundal varices are causes of UGIB \[4\].

Current strategies for managing UGIB emphasize early recognition and intervention. Endoscopy is the primary diagnostic and therapeutic modality, allowing for direct visualization of the gastrointestinal tract and enabling interventions such as cauterization, clipping, or band ligation to control bleeding \[5\]. Recent advancements in endoscopic techniques have improved outcomes by facilitating earlier detection and treatment of UGIB episodes. For instance, the use of hemostatic powders and over-the-scope clips has shown promise in managing refractory cases\[6,7\].

Endoscopic therapies may have resulted in earlier detection and treatment of UGIB, which could have led to a reduction in the incidence and severity of the condition. Upper GI endoscopy is considered the primary modality for identifying the underlying etiology and administering appropriate therapeutic measures to the patient present with upper GIT bleeding by ligation ,clips, electrocoagulation or by taking biopsies that help in diagnosis. The rationale for this research stems from the need to enhance understanding of UGIB's underlying causes and improve patient outcomes through timely endoscopic intervention. By identifying specific etiologies through upper endoscopy\[8,9\].

Eligibility criteria: Inclusion Criteria:

* Adult patients present with upper GIT bleeding of both gender older than 18 years old

Exclusion Criteria:

* 1- Patients younger than 18 2- Pregnant women 3- patients with end stage disease that not fit for endoscopic intervention

Primary outcomes:
measure: Endoscopic Findings in patients with upper GIT Bleeding
timeFrame: one year
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
References:
citation: Elsebaey MA, Elashry H, Elbedewy TA, Elhadidy AA, Esheba NE, Ezat S, Negm MS, Abo-Amer YE, Abgeegy ME, Elsergany HF, Mansour L, Abd-Elsalam S. Predictors of in-hospital mortality in a cohort of elderly Egyptian patients with acute upper gastrointestinal bleeding. Medicine (Baltimore). 2018 Apr;97(16):e0403. doi: 10.1097/MD.0000000000010403.