louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT01692665: Changes of Keratometric Value and Ocular Aberration After Treatment of Meibomian Gland Dysfunction
Study type: OBSERVATIONAL
Overall status: WITHDRAWN
Conditions: Moderate and Severe Meibomiang Gland Dysfunction (Stage 3 or Stage 4 Meibomiang Gland Dysfunction)
Keywords: meibomian gland dysfunction
keratometric value
ocular aberration
Lead sponsor: Yonsei University
Sponsor class: OTHER
First posted: 2012-09-25
Enrollment: 0
Sex: ALL
Minimum age (years): 20
Maximum age (years): 80
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: CASE_ONLY
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: stage 3 or stage 4 meibomiang gland dysfunction patients

Brief summary: Ocular aberration may play a role in determining optical quality. Recently performed study reported that ocular aberration of preocular tear film would be important factor in not only diagnosing the dry eye but also determining the efficacy of treatment. Therefore, in this study, the investigators will aim to prove the improvement of quality of vision via ocular aberration changes indirectly after the proper treatment for moderate and severe meibomian gland dysfunction. Also, the investigators will evaluate the changes of keratometric values after treatment for moderate and severe meibomian gland dysfunction, which could be demonstrated by autokeratometry, IOLMaster, Pentacam, and iTrace.


Eligibility criteria: Inclusion Criteria:

(1) stage 3 or 4 meibomian gland dysfunction

Exclusion Criteria:

1. history of previous ocular or intraocular surgery
2. ocular infection, non dry eye ocular inflammation, ocular allergy, autoimmune disease,
3. history of intolerance or hypersensitivity to any component of the study medications,
4. wearing contact lenses during the study period, presence of current punctal occlusion,
5. pregnancy, lactating women, and children.
6. Additionally, patients were excluded if they were using any topical ocular or systemic medication that could be used for the treatment MGD or dry eye, including topical or oral antibiotics, topical cyclosporine A, topical or oral steroids, topical non-steroidal anti-inflammatory drugs, topical ocular allergy medications or artificial tears

Primary outcomes:
measure: Changes of keratometric value and ocular aberration
timeFrame: a minimum of four minutes, once or twice dailybefore treatment, after 1 month, and after 2 months of treatment
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
References:
Clinical trial NCT04703465: Tenofovir Alafenamide for HBV Prophylaxis in HBV(-) Liver Transplant Recipients With HBcAb+ Donors
Official title: Effectiveness and Safety of Tenofovir Alafenamide for HBV Prophylaxis in HBV Negative Recipients Received Orthotopic Liver Transplant With HBcAb+ Donors
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: HBV
Liver Transplant Disorder
Lead sponsor: RenJi Hospital
Sponsor class: OTHER
First posted: 2021-01-11
Enrollment: 30
Sex: ALL
Minimum age (years): 12
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: PREVENTION

Brief summary: Liver transplantation is currently the only effective way to treat end-stage liver disease.The shortage of donor liver is still the major problem. Incidence of HBcAb+ varies between different regions. The HBcAb positive rate could be as high as 52% in China.HBcAb positive donor liver may enlarge donor pool and thus save ESLD patients. However, the use of HBcAb positive donor liver may induce HBV infection in hepatitis B negative recipient after liver transplantation. Tenofovir alafenamide (TAF) has better stability in plasma and higher liver targeting property in comparison with tenofovir (TDF), with an extra amide bond, which allows strong antiviral effect with much less doses and reducing the renal and bone injury. Our study intends to evaluate the efficacy and safety of HBV prophylaxis treatment of TAF in HBV negative patients after receiving HBcAb positive donor livers.

Detailed description: We intent to enroll 30 patients who are HBV negative but received HBcAb+ liver. Antiviral treatment with TAF(25mg/d,oral) will be started on the first day after liver transplantation. Post-operative HBV infection is defined with positive HBV marker (HBsAg) and/or positive HBV DNA after liver transplantation. Primary outcome will be evaluated at 48 weeks. All the patients will be followed up for another at least 1 year to evaluate the long term efficacy and safety of TAF.

The primary endpoint is to calculate de novo HBV infection after liver transplantation when treating with TAF. Secondary endpoint is to evaluate the renal safety of TAF after liver transplantation.

Eligibility criteria: Inclusion Criteria:

1. Patients with written informed consent.
2. Age ≥12 years old
3. HBV negative recipients (HBV DNA undetectable and HBsAg negative) receiving HBsAg-, HBcAb+ donor liver

Exclusion Criteria:

1. Patients underwent liver re-transplantation
2. CKD (CrCl\<30 ml/min by MDRD formula)
3. HBV/HCV-related OLT
4. Other solid organs transplant recipients
5. HIV coinfection

Primary outcomes:
measure: De novo HBV infected rate after liver transplantation at 48 weeks
timeFrame: 48 weeks
Secondary outcomes:
measure: 48 weeks Renal safety of TAF after liver transplantation.
timeFrame: 48 weeks
measure: 96 weeks Renal safety of TAF after liver transplantation.
timeFrame: 96 weeks
Other outcomes:
Locations:
Study officials:
affiliation: RenJi Hospital
name: Qiang Xia, MD., Ph.D.
role: STUDY_CHAIR
affiliation: RenJi Hospital
name: Zhifeng Xi, MD.
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT06938165: The Safety and Efficacy of Fecal Microbiota Transplant (FMT) for Steroid-refractory Graft-versus-host Disease
Official title: The Safety and Efficacy of Fecal Microbiota Transplant for Steroid-refractory Graft-versus-host Disease
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: GVHD
Keywords: GVHD
Lead sponsor: Nanfang Hospital, Southern Medical University
Sponsor class: OTHER
First posted: 2025-04-22
Enrollment: 46
Sex: ALL
Minimum age (years): 18
Maximum age (years): 65
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: TREATMENT

Brief summary: This clinical study evaluates the safety and efficacy of fecal microbiota transplantation (FMT) in patients with steroid-refractory graft-versus-host disease (GVHD).


Eligibility criteria: Inclusion Criteria:

1. Able and willing to sign the informed consent form and complete follow-up;
2. Aged 18-65 years, regardless of gender;
3. Patients with refractory GVHD.

Exclusion Criteria:

1. life-threatening or associated with severe non-GvHD complications;
2. Persistent malignant conditions;
3. Patients who have undergone second or multiple hematopoietic stem cell transplants;
4. History of severe allergic reactions;
5. Any condition that the investigator considers unsuitable for inclusion (such as any history, treatment history, or abnormal test data that may confound the study results, interfere with full participation in the study, or harm the patient's interests);

Primary outcomes:
measure: Overall Response Rate (ORR)
timeFrame: 12 weeks
Secondary outcomes:
measure: Number of Participants Experiencing an Adverse Event (AE)
timeFrame: 12 weeks
Other outcomes:
Locations:
city: Guangzhou
country: China
facility: Nanfang hospital
state: Guangdong
Study officials:
References:
Clinical trial NCT03526965: Yoga Chikitsa for Neck Pain Caused by Cervical Spondylosis
Official title: Yoga Chikitsa for Neck Pain Caused by Cervical Spondylosis: a Randomized Controlled Pilot Trial
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Cervical Spondylosis
Lead sponsor: NMP Medical Research Institute
Sponsor class: OTHER
Collaborators: name: Warwick Research Services
First posted: 2018-05-16
Enrollment: 117
Sex: ALL
Minimum age (years): 20
Maximum age (years): 80
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: SUPPORTIVE_CARE

Brief summary: Neck Pain caused by Cervical spondylosis (CS) is one of the most common health complaints. Despite its frequency as clinical problem worldwide, there are few evidence-based studies that document efficacy of therapies for neck pain. The aim of this study was to evaluate the effects of Yoga chikitsa (Yoga therapy) on pain and quality of life (QOL) in CS patients compared to usual care.


Eligibility criteria: Inclusion Criteria:

* Diagnosis of CS and confirmed by cervical radiographic examination
* Neck pain with CS
* Ready to Consent

Exclusion Criteria:

* Pregnancy
* Duration of neck pain \< 6 months
* Comorbid systematic condition (Diabetes, Cardiovascular)
* History of cervical surgery, cervical injury, or disease of bones or joints.

Primary outcomes:
measure: Neck Pain
timeFrame: Change from baseline to 6 weeks
Secondary outcomes:
measure: Quality of life
timeFrame: Change from baseline to 6 weeks
Other outcomes:
Locations:
city: Jaipur
country: India
facility: Pain Clinic, NMP Medical Research Institute
state: Rajasthan
Study officials:
affiliation: Warwick Research Services
name: Neha Sharma, PhD
role: STUDY_DIRECTOR
affiliation: NMP Medical Research Institute
name: Manoj Swami
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT02679365: Double Lock Versus Continuous Non-locking Technique for Closure of Rectus Sheath in Cesarean Sections on Post-operative Pain
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Postoperative Pain
Lead sponsor: Ain Shams Maternity Hospital
Sponsor class: OTHER
First posted: 2016-02-10
Enrollment: 150
Sex: FEMALE
Minimum age (years): 20
Maximum age (years): 40
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: SUPPORTIVE_CARE

Brief summary: In this trial we compare the effect of 2 closure techniques of the rectus sheath during cesarean sections on postoperative pain. One closure technique is double lock technique and the other is the conventional continuous non-locking technique.


Eligibility criteria: Inclusion Criteria:

* first cesarean section

Exclusion Criteria:

* urgent cesarean section
* previous abdominal surgery
* previous cesarean section
* obstetric and medical complications

Primary outcomes:
measure: postoperative pain evaluated by VAS
timeFrame: first week postoperative
Secondary outcomes:
measure: operative time
timeFrame: intraoperative
Other outcomes:
Locations:
Study officials:
References:
Clinical trial NCT02178865: Predicting Normal vs. Carrier Status in Euploid Embryos of Translocation Carriers
Official title: Evaluation of the Accuracy of Predicting Normal or Carrier Status in Euploid Embryos Produced by Patients With Balanced Translocations
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Balanced Chromosomal Translocation
Keywords: translocation
Lead sponsor: Reproductive Medicine Associates of New Jersey
Sponsor class: OTHER
First posted: 2014-07-01
Enrollment: 11
Sex: ALL
Minimum age (years): 7
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: CASE_ONLY
Time perspective: OTHER
Sampling method: NON_PROBABILITY_SAMPLE
Study population: patients with balanced translocations

Brief summary: The purpose of this study is to assess the accuracy of predicting the normal or carrier status of human embryos resulting from in vitro-fertilization (IVF) from patients carrying a balanced translocation.

Detailed description: This study aims to evaluate the validity of using informative SNPs to distinguish balanced from normal embryos. This will involve acquiring material from families to set phase for informative SNPs, evaluation of existing and new embryo SNP array data, and follow up analysis of children born after applying the procedure.

Eligibility criteria: Inclusion Criteria:

* patients with balanced translocations who have undergone IVF

Exclusion Criteria:

* those who do not wish to know their child(s) karyotype

Primary outcomes:
measure: Proportion of correct predictions of normal vs. balanced ploidy status as compared to conventional karyotype
timeFrame: up to 12 months once pregnant
Secondary outcomes:
Other outcomes:
Locations:
city: Basking Ridge
country: United States
facility: Reproductive Medicine Associates of New Jersey
state: New Jersey
Study officials:
affiliation: Reproductive Medicine Associates of New Jersey
name: Richard T Scott, MD, HCLD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT05379465: The Impact of the COVID-19 Pandemic on the Career Choice of Medicine
Official title: The Impact of the COVID-19 Pandemic on the Career Choice of Medicine: A Cross-Sectional Study Amongst Pre-Medical Students in Pakistan
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Career Choice of Medicine
Keywords: Medical education
Pre-Medical
Lead sponsor: Aga Khan University
Sponsor class: OTHER
First posted: 2022-05-18
Enrollment: 1695
Sex: ALL
Minimum age (years): 14
Maximum age (years): 20
Standard ages: CHILD
ADULT
Accepts healthy volunteers: yes
Observational model: OTHER
Time perspective: CROSS_SECTIONAL
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Pakistani high school students

Brief summary: The aim of this study is to determine what impact the COVID-19 pandemic may have had on the choices of high school students to pursue medicine as a career.

Detailed description: The COVID-19 pandemic poses an unprecedented global health crisis that has affected healthcare systems around the world. Those working in the health sector are at the forefront of this pandemic and naturally have been deeply impacted by it. Health care workers are at risk of serious physical exhaustion owing to long shifts, a major increase in workload and working under high-stress conditions. Shortage of Personal Protective Equipment (PPE) in many hospitals carries a serious health risk for not only healthcare workers but their families and patients as well. In addition to the physical toll that the pandemic has taken on doctors and other healthcare professionals, it has also affected their mental health deeply with an increase in anxiety and depression. Witnessing firsthand what this virus can do, yet stepping in daily into a high-risk area and exposing oneself to possible risk of infection, takes its toll on one's psychological well-being. However, the pandemic has allowed health care professionals to show higher levels of perseverance and professionalism in the face of the pandemic.

In view of how the COVID-19 pandemic has affected healthcare workers and the perception of the medical field around the world, the aim of this cross-sectional study is to determine what impact this may have had on the choices of high school students to pursue medicine as a career.

Eligibility criteria: Inclusion Criteria:

* Age ≥ 14 years old and ≤ 20 years old
* Enrolled in a high school in Pakistan for the academic year 2019-2020
* Can communicate in English

Exclusion Criteria:

- Studying a humanities, commerce, or pre-engineering track in high school

Primary outcomes:
measure: The change in the percentage (%) of students considering a career in medicine before the COVID-19 pandemic vs. after onset of the COVID-19 pandemic
timeFrame: 1 year
Secondary outcomes:
Other outcomes:
Locations:
city: Karachi
country: Pakistan
facility: Aga Khan University
state: Sindh
Study officials:
affiliation: Aga Khan University
name: Sarah Nadeem, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT05872165: Ozonated Gel Phonophoresis On Chronic Lateral Epicondylitis
Official title: Influence Of Ozonated Gel Phonophoresis In The Treatment Of Chronic Lateral Epicondylitis
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Epicondylitis
Lead sponsor: Cairo University
Sponsor class: OTHER
First posted: 2023-05-24
Enrollment: 40
Sex: ALL
Minimum age (years): 30
Maximum age (years): 50
Standard ages: ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: Comparison between 2 groups of chronic lateral epicondylitis, to determine the effect of ozonated media phonophoresis on chronic lateral epicondylitis.

Detailed description: 40 patients (male and female), patients age would be ranged from 30 to 50 years, would be randomly allocated using sealed envelope into randomly two matched group (A and B), Group A (Experimental): 20 patients would receive ultrasonic with ozonated gel as a coupling medium (phonophoresis) (1 MHz, 1 W/cm2continuous mode) for 5 min. plus, conventional physical therapy program consists of (conventional TENS (100 Hz) for 30 min - hot pack for 20 min- stretching and strengthening exercises, wrist rest splints). 3 times per week for 4 weeks.

Group B (control):20 patients will receive conventional physical therapy program consists of (conventional TENS (100 Hz) for 30 min - hot pack for 20 min- stretching and strengthening exercises, wrist rest splints) 3times per week for 4 weeks.

Eligibility criteria: Inclusion Criteria:

* All patients would be diagnosed as chronic lateral epicondylitis from both genders.
* Patients with chronic lateral epicondylitis that diagnosed by orthopedist.
* Positive clinical manifestation in all patients.
* Pain onset is more than 3 months.
* All participants must be medically stable and not be treated with analgesics or any medication which may cause misleading results.
* All patients had body mass index between 18.5 and 29.9 kg/m2.

Exclusion Criteria:

* Subjects would be excluded if they have:

Received intra articular injection from duration less than 3 months.

* Elbow instability.
* History of cancer.
* Pregnancy
* Infection.
* Skin diseases on elbow area.
* Open wound in elbow.
* Shoulder or elbow fractures
* Systemic diseases such as rheumatoid arthritis, Reiter's syndrome, or diabetes.
* Neurological diseases.
* Severe medical or psychiatric disorders.
* Elbow surgery.
* Entrapment of the radial nerve.
* Arthritis and effusion of the elbow.

Primary outcomes:
measure: Pain status
timeFrame: 4 weeks
measure: wrist ROM
timeFrame: 4 weeks
measure: Hand grip strength
timeFrame: 4 weeks
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
References:
Clinical trial NCT05062265: Internal Brace Augmented Anterior Inferior Tibiofibular Ligament Repair: Post-operative Syndesmotic Volumes.
Official title: Internal Brace Augmented Anterior Inferior Tibiofibular Ligament Repair and Its Post-operative Effects on Syndesmotic Volumes: A Prospective, Single-blinded, Randomized Study
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Syndesmotic Injuries
Ligament Rupture
Bimalleolar Fractures
Trimalleolar Fractures
Lead sponsor: Vann Virginia Center for Orthopaedics dba Atlantic Orthopaedic Specialists
Sponsor class: OTHER
Collaborators: name: Arthrex, Inc.
First posted: 2021-09-30
Enrollment: 23
Sex: ALL
Minimum age (years): 18
Maximum age (years): 80
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: DIAGNOSTIC

Brief summary: Over the course of a year from the start of the research study, twenty subjects will be randomized evenly into one of two groups after an informed consent is obtained: a traditional tight rope fixation group or a tight rope fixation with an anterior inferior tibiofibular ligament (AITFL) repair augmentation with an internal brace group. Postoperative reduction was assessed by 3D volumetric ratios and measured by weight-bearing CT at 6-weeks and 3-months post-operation. Patient Reported Outcomes (PROs) were collected preoperatively, and at 6-weeks, 3-months, 6-months, and 1-year post-operation and included the Foot and Ankle Outcome Score and the 36-Item Short Form Survey Instrument (RAND-36) . Differences in volumetric ratios and PROs were evaluated between groups and time periods.


Eligibility criteria: Inclusion Criteria:

* patients who fit the study injury list

Exclusion Criteria:

* smokers
* prior surgery on ankle
* bi-lateral surgery
* recent participation in another study within the last 90days

Primary outcomes:
measure: Syndesmotic Volumetric Ratio
timeFrame: 6-Weeks Post-op
measure: Syndesmotic Volumetric Ratio
timeFrame: 3 months post-operative volume
Secondary outcomes:
measure: 36-Item Short Form Survey Instrument (RAND-36) Summary Scores
timeFrame: 6 weeks post-operative
measure: RAND-36 Summary Scores
timeFrame: 3 months post-operative
measure: RAND-36 Summary Scores
timeFrame: 6 months post-operative
measure: RAND-36 Summary Scores
timeFrame: 1 year post-operative
measure: Foot and Ankle Outcome Score (FAOS)
timeFrame: 6 weeks post-operative
measure: Foot and Ankle Outcome Score (FAOS)
timeFrame: 3 months post-operative
measure: Foot and Ankle Outcome Score (FAOS)
timeFrame: 6 months post-operative
measure: Foot and Ankle Outcome Score (FAOS)
timeFrame: 1 year post-operative
Other outcomes:
Locations:
city: Virginia Beach
country: United States
facility: Atlantic Orthopaedic Specialists
state: Virginia
Study officials:
affiliation: Vann Virginia Center for Orthopaedics dba Atlantic Orthopaedic Specialists
name: Blake E Moore, MD
role: PRINCIPAL_INVESTIGATOR
affiliation: Clinical Researcher
name: Ashley Suttmiller, PhD
role: STUDY_CHAIR
affiliation: Director of Clinical Research
name: Brice A Snyder, MSAT
role: STUDY_DIRECTOR
References:
Clinical trial NCT02090465: Assessment of Treatment Success and Quality of Life in Patients With Actinic Keratoses Under Therapy With Ingenol Mebutate in a Period of 8 Weeks
Official title: Assessment of Treatment Success and Quality of Life in Patients With Actinic Keratoses Under Therapy With Ingenol Mebutate (Picato) in a Period of 8 Weeks.
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Actinic Keratosis
Keywords: Actinic Keratosis
Lead sponsor: LEO Pharma
Sponsor class: INDUSTRY
First posted: 2014-03-18
Enrollment: 840
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: patients with actinic keratosis contacting their dermatologist

Brief summary: Assessment of treatment success and quality of life in patients with actinic keratoses under therapy with Ingenol Mebutate (Picato) in a period of 8 weeks.

Detailed description: Non-interventional (observational) study (NIS), non-controlled, prospective cohort study.

Eligibility criteria: Inclusion Criteria:

• Non-hyperkeratotic, non-hypertrophic actinic keratoses where treatment with Picato® is indicated and the treatment is intended by physicians.

Exclusion Criteria:

* Preceding use of Picato® on the area planned for treatment
* Any other specific local treatment of actinic keratoses on the area planned for treatment during the last 8 weeks
* Melanoma, squamous cell carcinoma or spinalioma on the area planned for treatment
* Open wounds on the area planned for treatment
* Contraindications according to prescribing information

Primary outcomes:
measure: Actinic keratosis
timeFrame: 8 weeks
measure: Skindex-16
timeFrame: 8 weeks
measure: Dosage of Picato®
timeFrame: 8 weeks
Secondary outcomes:
Other outcomes:
Locations:
city: Heidelberg
country: Germany
facility: Universitätsklinikum Heidelberg/Klinische Sozialmedizin
Study officials:
affiliation: University Hospital Heidelberg
name: Thomas Diepgen, Prof. Dr. med.
role: PRINCIPAL_INVESTIGATOR
References: