louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT05916456: Hand10 Questionnaire in Individuals With Carpal Tunnel Syndrome
Official title: Investigation of the Validity and Reliability of the Hand10 Questionnaire in Individuals With Carpal Tunnel Syndrome
Study type: OBSERVATIONAL
Overall status: ACTIVE_NOT_RECRUITING
Conditions: Carpal Tunnel Syndrome
Keywords: carpal tunnel syndrome
DASH questionnaire
Boston carpal tunnel syndrome questionnaire
HAND10 questionnaire
validity and reliability
Lead sponsor: Hasan Kalyoncu University
Sponsor class: OTHER
First posted: 2023-06-23
Enrollment: 100
Sex: ALL
Minimum age (years): 18
Maximum age (years): 70
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: OTHER
Time perspective: CROSS_SECTIONAL
Sampling method: PROBABILITY_SAMPLE
Study population: Our study will be conducted with individuals between the ages of 18-70 who have been diagnosed with CTS.

Brief summary: Hand10 questionnaire, Boston Carpal Tunnel Syndrome Questionnaire and Arm Shoulder Questionnaire for patients with carpal tunnel syndrome and Hand Deficiencies Questionnaire (DASH) will be applied one week apart to investigate the validity of the questionnaire.

Test-retest reliability and internal consistency will be determined using Intraclass Correlation Coefficient analysis and Cronbach alpha, respectively. The validity of Hand10 in individuals with CST will be determined using the Pearson Correlation Coefficient analysis, the Arm, Shoulder, and Hand Disability Questionnaire and the Boston Carpal Tunnel Syndrome Questionnaire.


Eligibility criteria: Inclusion Criteria:

* Patients who volunteer for treatment
* 18-70 years old patients
* With patients diagnosed with CTS

Exclusion Criteria:

-Patients who have had surgery on the wrist area

Primary outcomes:
measure: The validity and reliability of the Hand10 questionnaire to individuals with carpal tunnel scan included
timeFrame: 3 month
Secondary outcomes:
Other outcomes:
Locations:
city: Gaziantep
country: Turkey
facility: Hasan Kalyoncu Universty
state: Sahinbey
Study officials:
References:
Clinical trial NCT01681056: Efficacy Study of Autosuggestion for Quality of Life of Geriatric Patients
Official title: Quality of Life and Psycho-Neuro-Endocrine-Immunology Pathway of Geriatric Patients: A Trial of Autosuggestion
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Quality of Life for Geriatric Patients.
Keywords: autosuggestion
quality of life
geriatric
serum cortisol
Interferon gamma
interleukin-2
interleukin-6
neuroplasticity
Lead sponsor: Indonesia University
Sponsor class: OTHER
First posted: 2012-09-07
Enrollment: 51
Sex: ALL
Minimum age (years): 60
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The objective is to analyze the efficacy of autosuggestion for geriatric patients's quality of life and its impact to psycho-neuro-endocrine-immune pathways. The primary outcome is quality of life.

The hypothesis of this study is that autosuggestion will increase geriatric patient's quality of life based on its impact to psycho-neuro-endocrine-immune pathways.

Detailed description: Geriatric patients diagnosed with multipathology after getting information and signing informed consent will be included in this trial. Autosuggestion was created by patients according to their preferences, modified by researcher to accomplish autosuggestion principles, recorded in a tape to be heard by walkman daily for 30 days. Intervention and control groups received usual standard medical therapy.

Baseline data were collected within one week after admission. Then the subject will be followed up for 30 days. Primary outcome was quality of life measured by COOP chart, analyze using on treatment analysis. Secondary outcomes were serum cortisol, interleukin-2, interleukin-6, IFN-ϒ (Interferon gamma), and N Acetyl Aspartat/ creatine ratio in limbic and paralimbic system by Magnetic Resonance Spectroscopy.

Eligibility criteria: Inclusion Criteria:

* Age: ≥ 60 years old with multipathology, inpatients
* Not in steroid therapy
* Could communicate (Karnofsky score: 40% or Zubrod/WHO score: 3)
* Cooperative
* Willing to go through all of the research steps.

Exclusion Criteria:

* Stroke
* Multiple Sclerosis
* Brain Tumour
* Using Pace maker

Primary outcomes:
measure: Quality of Life
timeFrame: 30 days
Secondary outcomes:
measure: Serum Cortisol (ng/mL)
timeFrame: 30 days
measure: Interleukin-2 (pg/mL)
timeFrame: 30 days
measure: Interleukin-6 (pg/mL)
timeFrame: 30 days
measure: Interferon Gamma (pg/mL)
timeFrame: 30 days
measure: N Acetyl Aspartat/ creatine ratio in limbic and paralimbic system (amygdala, hippocampus, hypothalamus, temporal lobe, accumbens nuclei, prefrontal cortex)
timeFrame: 30 days
Other outcomes:
Locations:
city: Jakarta
country: Indonesia
facility: Dr. Cipto Mangunkusumo Hospital
state: DKI Jakarta
Study officials:
affiliation: Indonesia University
name: Nina K Sari, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT01109056: Safety and Efficacy of Cyclosporine Ophthalmic Emulsion in Patients With Primary Pterygium
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE2
Conditions: Pterygium
Lead sponsor: Allergan
Sponsor class: INDUSTRY
First posted: 2010-04-22
Enrollment: 115
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: This study will evaluate the safety and efficacy of Cyclosporine Ophthalmic Emulsion 0.05% (RESTASIS®) in patients with primary pterygium (abnormal growth on surface of eye).


Eligibility criteria: Inclusion Criteria:

* Have a pterygium in at least one eye that has not been previously removed with surgery

Exclusion Criteria:

* Uncontrolled systemic disease
* Active eye disease
* Current or anticipated use of topical eye medications other than artificial tears.
* Anticipated wearing of contact lenses

Primary outcomes:
measure: Number of Pterygium Hyperemia Responders at Week 16
timeFrame: Week 16
measure: Change From Baseline in Severity Grade of Pterygium Hyperemia at Week 16
timeFrame: Baseline, Week 16
Secondary outcomes:
measure: Change From Baseline in Ocular Surface Disease Index© (OSDI©) Questionnaire Score at Week 16
timeFrame: Baseline, Week 16
Other outcomes:
Locations:
city: Glendale
country: United States
state: California
city: Randwick
country: Australia
state: New South Wales
city: Singapore
country: Singapore
Study officials:
affiliation: Allergan
name: Medical Director
role: STUDY_DIRECTOR
References:
Clinical trial NCT03660956: Effects of Exercise and Back Counselling for Nurses
Official title: Comparative Effects of Exercise and Back Counselling on Improving Low Back Pain for Nurses
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Low Back Pain
Lead sponsor: China Medical University Hospital
Sponsor class: OTHER
First posted: 2018-09-07
Enrollment: 4
Sex: ALL
Minimum age (years): 20
Maximum age (years): 65
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Intervention model description: A Quasi-Experimental design is used in this study. Participants are randomly assigned to exercise and back counselling group or back counselling only group.
Primary purpose: PREVENTION

Brief summary: Low back pain (LBP) is most common occupational health problem among nurses. Therefore, how to prevent and reduce low back pain have been the important issue for nurses. A Quasi-Experimental design is used in this study to compare the effectiveness of 12-week exercise and counselling program to reduce low back pain in nursing personnel compared with counselling alone.

Detailed description: A Quasi-Experimental design is used in this study. Purposive sampling is used to recruit participants from medical center in Central Taiwan. Participants will be randomly assigned to two groups: (1) exercise and back counselling, and (2) back counselling only. The results of this study will provide a guideline for nurses to prevent and to improve low back pain.

Eligibility criteria: Inclusion Criteria:

1. Has worked at current job for at least 12 months;
2. Intensity of low back pain on Visual Analogue Scale (scale 0-10) at least two during the past 3 months.

Exclusion Criteria:

1. Serious former back injury (fracture, surgery, disc protrusion);
2. Pregnant;
3. Other serious disease or symptoms that limit participation exercise defined by a physician.

Primary outcomes:
measure: Change from Baseline in Pain on Visual Analogue Scale (VAS) at week 6, week 12, month 3, and month 6
timeFrame: Baseline, week 6, week 12, month 3, month 6.
Secondary outcomes:
measure: Change from Baseline Musculoskeletal Symptoms in the Low Back Area at week 6, week 12, month 3 and month 6
timeFrame: Baseline, week 6, week 12, month 3, month 6.
measure: Change from Baseline Functional Status at week 6, week 12, month 3 and month 6
timeFrame: Baseline, week 6, week 12, month 3, month 6
Other outcomes:
Locations:
city: Taichung
country: Taiwan
facility: China Medical University
Study officials:
affiliation: China Medical University, China
name: Hsin-Hsin Shih, PhD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT02180256: Effect of Endometrial Scratching on Assisted Reproduction Outcomes: a Randomized Controlled Trial
Study type: INTERVENTIONAL
Overall status: TERMINATED
Phase: NA
Conditions: Subfertility
Keywords: IVF
ICSI
Embryo transfer
Assisted reproduction
Endometrial injury
Endometrial scratching
Lead sponsor: University of Sao Paulo
Sponsor class: OTHER
Collaborators: name: Conselho Nacional de Desenvolvimento Científico e Tecnológico
First posted: 2014-07-02
Enrollment: 107
Sex: FEMALE
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: SUPPORTIVE_CARE

Brief summary: To examine whether endometrial scratching (or injury) using a Pipelle endometrial sampler, performed on the first seven days of the menstrual cycle, is able to improve pregnancy rates in women who will be submitted to a fresh embryo transfer.


Eligibility criteria: Inclusion Criteria:

* Age ≥ 18 years
* First four days of the menstrual cycle, just before starting controlled ovarian stimulation for planned IVF and fresh embryo transfer.
* Not have performed endometrial scratching in the last 90 days.

Exclusion Criteria:

* None

Primary outcomes:
measure: Live birth
timeFrame: 1 year
Secondary outcomes:
measure: Clinical pregnancy
timeFrame: 8 weeks
measure: Miscarriage
timeFrame: 20 weeks
measure: Multiple pregnancy
timeFrame: 8 weeks
Other outcomes:
measure: Implantation rate
timeFrame: 8 weeks
Locations:
city: Ribeirao Preto
country: Brazil
facility: Hc-Fmrp-Usp
state: Sao Paulo
Study officials:
affiliation: University of Sao Paulo
name: Wellington P Martins, PhD
role: PRINCIPAL_INVESTIGATOR
References:
citation: Nastri CO, Teixeira DM, Ferriani RA, Martins WP. The overlooked endometrial injury underlying hysteroscopy procedures. Reprod Biomed Online. 2014 Jul;29(1):140. doi: 10.1016/j.rbmo.2014.03.021. Epub 2014 Apr 28. No abstract available.
citation: Nastri CO, Ferriani RA, Raine-Fenning N, Martins WP. Endometrial scratching performed in the non-transfer cycle and outcome of assisted reproduction: a randomized controlled trial. Ultrasound Obstet Gynecol. 2013 Oct;42(4):375-82. doi: 10.1002/uog.12539. Epub 2013 Sep 2.
citation: Nastri CO, Teixeira DM, Martins WP. Endometrial injury in the menstrual cycle prior to assisted reproduction techniques to improve reproductive outcomes. Gynecol Endocrinol. 2013 May;29(5):401-2. doi: 10.3109/09513590.2012.760193. Epub 2013 Jan 22. No abstract available.
citation: Nastri CO, Gibreel A, Raine-Fenning N, Maheshwari A, Ferriani RA, Bhattacharya S, Martins WP. Endometrial injury in women undergoing assisted reproductive techniques. Cochrane Database Syst Rev. 2012 Jul 11;(7):CD009517. doi: 10.1002/14651858.CD009517.pub2.
Clinical trial NCT00067756: 4-PBA: Will it Increase the Level of Alpha 1-Antitrypsin(AAT) in Persons With AAT Deficiency?
Official title: "4 Phenyl Butyrate Mediated Secretion Rescue in Alpha 1-Antitrypsin Deficient Individuals"
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE2
Conditions: Alpha 1-Antitrypsin Deficiency
Keywords: Pulmonary Disease
Liver Disease
Lead sponsor: University of Florida
Sponsor class: OTHER
Collaborators: name: Alpha-1 Foundation
name: Brantly, Mark L., M.D.
First posted: 2003-08-27
Enrollment: 12
Sex: ALL
Minimum age (years): 18
Maximum age (years): 65
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: TREATMENT

Brief summary: The purpose of this study is to find out whether 4-PBA will increase the level of AAT in persons with AAT deficiency whether or not they have liver disease.

Detailed description: The purpose of this study is to determine whether 4-PBA will significantly increase serum Z AAT levels in AAT-deficient individuals with and without evidence of hepatocellular injury and to assess its effects on liver injury.

Eligibility criteria: Inclusion Criteria:

* Age 18-65
* Serum A1-PI levels \<11uM an appropriate genetic phenotype/genotype
* 5 of 10 subjects must have documented laboratory evidence of liver disease
* Willingness to withhold Prolastin therapy for 6 weeks prior to screening and throughout the 4-PBA dosing period (up to 3 months)

Exclusion Criteria:

* Any cause of liver disease other than Alpha-1 Antitrypsin deficiency
* Evidence of advanced liver disease
* HIV positive
* Use of systemic steroids, ursodeoxycholic acid (Actigall, Urso), or herbs in the prior 6 months

Primary outcomes:
measure: To determine if 4-PBA significantly increases secretion of AAT in AAT-deficient individuals with and without liver disease.
timeFrame: 10 days
Secondary outcomes:
measure: To determine the pharmacokinetics of 4-PBA
timeFrame: 10 days
Other outcomes:
Locations:
city: Gainesville
country: United States
facility: University of Florida
state: Florida
Study officials:
affiliation: University of Florida
name: Mark L Brantly, MD
role: PRINCIPAL_INVESTIGATOR
References:
citation: Gonzalez-Peralta RP, Leonard S, Harvey R, Schreck P, Vironosvkaya N, Brantly ML. 4-PHENYL BUTYRATE MEDIATED SECRETION RESCUE IN PATIENTS WITH ALPHA 1-ANTITRYPSIN (AAT) DEFICIENCY: A PILOT STUDY HEPATOLOGY, Vol. 44, No. 4, Suppl. 1, 2006 AASLD ABSTRACTS, p. 211A, 61
Clinical trial NCT02446756: Clinical Observation and MRI Influence of Acupuncture on Knee Osteoarthritis
Official title: Clinical Observation and MRI Influence of Acupuncture on Knee Osteoarthritis
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Knee Arthritis Osteoarthritis
Keywords: Osteoarthritis
MRI
Cartilage
Acupuncture
Lead sponsor: Peking Union Medical College Hospital
Sponsor class: OTHER
First posted: 2015-05-18
Enrollment: 50
Sex: ALL
Minimum age (years): 30
Maximum age (years): 80
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: To observe the therapeutic effect of acupuncture on osteoarthritis(OA) and its efficacy on cartilage restoration,acupuncture and physiotherapy treatment were respectively given to two random groups. Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) was used to evaluate the motor function of knee joints, followed by magnetic resonance imaging (MRI) scanning to measure T2 values in ten cartilage sub-regions in tibiofemoral joints.

Detailed description: To observe the therapeutic effect of acupuncture on osteoarthritis and its efficacy on cartilage restoration,one hundred knees of 50 patients with knee osteoarthritis were randomly divided into acupuncture group and physiotherapy group which were respectively received acupuncture and physiotherapy treatment for four weeks. Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) was used to evaluate the motor function of knee joints, followed by magnetic resonance imaging (MRI) scanning to measure T2 values in ten cartilage sub-regions in tibiofemoral joints.

Eligibility criteria: Inclusion Criteria:

* Clinically diagnosed as knee osteoarthritis according to the OA criteria proposed by American College of Rheumatology in 1995.

Exclusion Criteria:

* Acute knee injury
* Had ever accepted therapy as hormone or injection in articulation cavity
* Had ever accepted treatment as oral medicine, physiotherapy, acupuncture or massage during the passed three months
* Had planted cardiac pacemaker or any metal matter in body
* Other severe diseases such as heart, lung, liver, kidney or cerebrum failure, tumors, gastrointestinal hemorrhage and so on
* Pregnant or lactating woman
* Anyone unable to tolerate or cooperate with treatment.

Primary outcomes:
measure: WOMAC scores
timeFrame: up to 24 months
measure: T2 Values
timeFrame: up to 30 months
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
References:
Clinical trial NCT04604756: The Effects of Losartan on Social Reward
Official title: Losartan Effects on the Social Reward in Humans
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Healthy
Keywords: Losartan
Social reward
Lead sponsor: University of Electronic Science and Technology of China
Sponsor class: OTHER
First posted: 2020-10-27
Enrollment: 90
Sex: ALL
Minimum age (years): 18
Maximum age (years): 30
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: BASIC_SCIENCE

Brief summary: The aim of the study is to investigate the effect of losartan (50mg, single dose) on social reward

Detailed description: In a double-blind, between-subject, placebo-controlled design the effects of a single dose of losartan (50mg) on social reward in healthy participants will be examined. 90 minutes after subjects administrate 50mg losartan or placebo, participants will undergo a social incentive delay task. Neural activity will be assessed by the acquisition of functional magnetic resonance imaging (fMRI) data.

Eligibility criteria: Inclusion Criteria:

* Healthy subjects without past or current psychiatric or neurological disorders

Exclusion Criteria:

* history of head injury
* medical or psychiatric illness
* hypertension

Primary outcomes:
measure: Losartan effects on neural activity as assessed by blood oxygenation dependent (BOLD) fMRI during the anticipation of social feedback.
timeFrame: 90 minutes to 105 minutes after treatment
measure: Losartan effects on neural activity as assessed by blood oxygenation dependent (BOLD) fMRI during the consummation of social feedback.
timeFrame: 90 minutes to 105 minutes after treatment
Secondary outcomes:
measure: Effects of Losartan on arousal ratings of the stimuli presented during the fMRI-paradigm as assessed by 1-9 Likert scales
timeFrame: 150 minutes to 160 minutes after treatment
measure: Effects of Losartan on valence ratings of the stimuli presented during the fMRI-paradigm as assessed by 1-9 Likert scales
timeFrame: 150 minutes to 160 minutes after treatment
measure: Effects of Losartan on intensity ratings of the stimuli presented during the fMRI-paradigm as assessed by 1-9 Likert scales
timeFrame: 150 minutes to 160 minutes after treatment
measure: Effects of Losartan on likeability ratings of the stimuli presented during the fMRI-paradigm as assessed by 1-9 Likert scales
timeFrame: 150 minutes to 160 minutes after treatment
measure: Effects of Losartan on dislikeability ratings of the stimuli presented during the fMRI-paradigm as assessed by 1-9 Likert scales
timeFrame: 150 minutes to 160 minutes after treatment
Other outcomes:
Locations:
city: Chengdu
country: China
facility: University of Electronic Science and Technology of China
state: Sichuan
Study officials:
affiliation: University of Electronic Science and Technology of China
name: Benjamin Becker, PhD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT05400356: Dynamics of Immune Map and Outcomes After On-pump Cardiac Surgery: Protocol for a Prospective Cohort Study
Official title: Dynamics of Immune Map and Outcomes After On-pump Cardiac Surgery: Protocol for a Prospective Cohort Study
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: On-pump Valve Surgery or CABG
Lead sponsor: West China Hospital
Sponsor class: OTHER
First posted: 2022-06-01
Enrollment: 120
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: Participants are recruited from West China Hospital of Sichuan University who would undergo cardiac surgery under CPB between June 2022 and December 2022

Brief summary: Although systemic inflammatory response induced by cardiopulmonary bypass is believed as one of main reasons for these adverse events, the involved mechanism is still unclear.This cohort study would include patients undergoing on-pump valve surgery or CABG. By detecting the changes of immune cell expression profile and inflammatory related substances in blood, the spatiotemporal change curve of immune function of patients is drawn for avoiding or treating adverse events.


Eligibility criteria: Inclusion Criteria:

* (1) participants aged over 18 years; (2) Participants who scheduled for valve replacement or valvuloplasty, coronary artery bypass under CPB.

Exclusion Criteria:

* (1) participant with a cognitive or mental disorder who is unable to sign an informed consent form; (2) suffering from basic immune system and blood system diseases; (3) pregnancy; (4) preoperative radiotherapy and chemotherapy; (5) receive immunosuppressive drugs within six months;(6) Expected survival time less than 2 years;(7) participated in other intervention clinical trials within 30 days before operation.

Primary outcomes:
measure: composite outcome
timeFrame: From the beginning of surgery to 30 days after surgery or to discharge from hospital
Secondary outcomes:
measure: Infection
timeFrame: From the beginning of surgery to 30 days after surgery or to discharge from hospital]
measure: MACCE
timeFrame: From the beginning of surgery to 30 days after surgery or to discharge from hospital]
measure: Acute lung injury
timeFrame: From the beginning of surgery to 30 days after surgery or to discharge from hospital]
measure: Gastrointestinal complications
timeFrame: From the beginning of surgery to 30 days after surgery or to discharge from hospital
Other outcomes:
Locations:
city: Chengdu
country: China
facility: West China Hospital of Sichuan University
state: Sichuan
Study officials:
References: