Clinical trial NCT05135078: Monitoring Risks for Hematological Changes in Gas Station Workers
Official title: Monitoring Risks for Hematological Changes in Gas Station Workers
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Hematologic Diseases
Lead sponsor: Sohag University
Sponsor class: OTHER
First posted: 2021-11-26
Enrollment: 50
Sex: MALE
Standard ages: CHILD
ADULT
OLDER_ADULT
Observational model: CASE_ONLY
Time perspective: CROSS_SECTIONAL
Sampling method: PROBABILITY_SAMPLE
Study population: gas station workers exposed to benzene more than 3 years

Brief summary: Gas station workers are exposed to carcinogenic substances.This increases risk of their exposure to hematological diseases such as lymphoblastic leukemia (ALL), chronic lymphocytic leukemia (CLL), myelodysplastic syndromes (MDS), and myelogenous leukemia (AML), as well as different forms of non-Hodgkin's lymphoma (NHL) and multiple myeloma. Thus, the early identification of this condition between the gas station workers may prevent the hematological disease progression.

Detailed description: Gas station workers are exposed to carcinogenic substances.This increases risk of their exposure to hematological diseases such as lymphoblastic leukemia (ALL), chronic lymphocytic leukemia (CLL), myelodysplastic syndromes (MDS), and myelogenous leukemia (AML), as well as different forms of non-Hodgkin's lymphoma (NHL) and multiple myeloma.

It is known that severe bone marrow dysplasia is frequently accompanied by early alterations in the immune system and in peripheral cell subsets.

The bone marrow injury by benzene metabolites is a strong predisposing factor in the pathogenesis of Benzene-induced hematopoietic disease .Thus, the early identification of this condition between the gas station workers may prevent the hematological disease progression.

The reactive metabolite of benzene, 1,4-benzoquinone (BQ) is suggested to be a key molecule of benzene-induced hematotoxicity and carcinogenicity as it cause abnormal accumulation of myeloid cells and precursors, which cause benzene induced cytopenia and myeloid dysplasia in humans.

Eligibility criteria: Inclusion Criteria:

* This study will be conducted on a group of gas station workers exposed to benzene for more than 3 years .

Exclusion Criteria:

* diagnosed gas station workers with blood malignancies .
* gas station workers exposed to benzene for less than 3 years .

Primary outcomes:
measure: The aim of study is to evaluate and monitor risks for hematological changes in gas station workers
timeFrame: within 6 months .
measure: The aim of study is to evaluate and monitor risks for hematological changes in gas station workers
timeFrame: within 6 months .
measure: The aim of study is to evaluate and monitor risks for hematological changes in gas station workers
timeFrame: within 6 months .
measure: The aim of study is to evaluate and monitor risks for hematological changes in gas station workers
timeFrame: within 6 months .
measure: The aim of study is to evaluate and monitor risks for hematological changes in gas station workers
timeFrame: within 6 months ,
Secondary outcomes:
Other outcomes:
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