Clinical trial NCT02103907: Randomized Controlled Trial of Dynamic Balance Training in People With Knee Osteoarthritis
Official title: The Effect of Dynamic Balance Training on Balance and Physical Function in Those With Knee Osteoarthritis
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Knee Osteoarthritis
Keywords: balance
knee
osteoarthritis
physical function
Lead sponsor: University of British Columbia
Sponsor class: OTHER
Collaborators: name: Arthritis Health Professions Association
First posted: 2014-04-04
Enrollment: 40
Sex: ALL
Minimum age (years): 50
Maximum age (years): 80
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: There is a high prevalence of falls in those with knee osteoarthritis (OA) compared to healthy older adults. Balance is a key element of function that allows individuals to maintain posture and respond to perturbations, and poor balance control, a risk factor for falls, has been noted in those with knee OA. There is a lack of research guiding treatment for balance deficits in knee OA, with interventions aimed at improving balance deficits in those with knee OA having mixed results. Targeted dynamic balance interventions in other patient populations have been shown to significantly improve dynamic balance control and physical function. If results similar to such populations can be achieved, such a program may produce a significant reduction in functional disability in the knee OA population and improve quality of life. The purpose of this study is to examine the effect of a 10-week targeted dynamic balance intervention on dynamic balance and physical function in people with knee OA. This will be a randomized controlled trial (RCT).


Eligibility criteria: Inclusion Criteria:

* age 50 - 80 years (to meet the American College of Rheumatology clinical definition of OA)
* radiographically confirmed knee OA in the medial compartment of the tibiofemoral joint
* predominance of pain/tenderness over the medial (inside) region of the knee

Exclusion Criteria:

* articular cartilage degradation in the lateral tibiofemoral compartment greater than the medial
* inflammatory arthritic condition
* history of knee or hip replacement surgery
* recent use of corticosteroids (oral or via injection, within last 6 months)
* pain originating predominantly from the patellofemoral joint
* inability to ambulate without a gait aid
* non-English speaking
* recent (within 6 months) arthroscopic knee surgery
* significant hip or back pain (limits the ability to perform the testing)
* Neurological, musculoskeletal or other condition that affects movement ability or balance (i.e. stroke, diabetes, Parkinson's, heart attack, multiple sclerosis, fibromyalgia)

Primary outcomes:
measure: Change in dynamic balance and mobility from baseline
timeFrame: 0, 10 weeks
measure: Change in self-reported physical function from baseline
timeFrame: 0, 10 weeks
Secondary outcomes:
measure: Change in knee pain from baseline
timeFrame: 0, 10 weeks
measure: Change in fear of pain from baseline
timeFrame: 0, 10 weeks
measure: Change in self-reported physical activity level from baseline
timeFrame: 0, 10 weeks
measure: Change in knee joint proprioception from baseline
timeFrame: 0, 10 weeks
measure: Change in muscle strength from baseline
timeFrame: 0, 10 weeks
measure: Change in knee joint range of motion from baseline
timeFrame: 0, 10 weeks
Other outcomes:
measure: Ratio of number of exercise sessions attended to the maximum
timeFrame: 10 weeks
measure: Number of participants with adverse events
timeFrame: 10 weeks
measure: Change in medication use
timeFrame: 10 weeks
measure: Change in co-interventions
timeFrame: 10 weeks
Locations:
city: Vancouver
country: Canada
facility: Motion Analysis and Biofeedback Laboratory, The University of British Columbia
state: British Columbia
Study officials:
affiliation: University of British Columbia
name: Michael A Hunt, PT, PhD
role: PRINCIPAL_INVESTIGATOR
References:
citation: Takacs J, Krowchuk NM, Garland SJ, Carpenter MG, Hunt MA. Dynamic Balance Training Improves Physical Function in Individuals With Knee Osteoarthritis: A Pilot Randomized Controlled Trial. Arch Phys Med Rehabil. 2017 Aug;98(8):1586-1593. doi: 10.1016/j.apmr.2017.01.029. Epub 2017 Mar 6.