Clinical trial NCT03963271: Noninvasive Electrocardiographic Imaging for Individuals at Risk for Apparently Idiopathic Ventricular Fibrillation.
Official title: Noninvasive Electrocardiographic Imaging for Individuals at Risk for Apparently Idiopathic Ventricular Fibrillation.
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Ventricular Fibrillation
Ventricular Arrythmia
Polymorphic Ventricular Tachycardia
Sudden Cardiac Death
Heart Arrest
Cardiovascular Diseases
Cardiac Arrhythmia
Genetic Disease
Idiopathic Ventricular Fibrillation
Cardiac Arrest
Keywords: idiopathic ventricular fibrillation
polymorphic ventricular tachycardia
body surface potential mapping
ECG Imaging
Lead sponsor: Maastricht University Medical Center
Sponsor class: OTHER
Collaborators: name: Dutch Heart Foundation
name: Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
name: UMC Utrecht
First posted: 2019-05-24
Enrollment: 500
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: patients seen at the outpatient clinic at the department of cardiology or (cardio)genetics, patients admitted to the ward of cardiology or the intensive care unit.

Brief summary: This study aims to evaluate the electrophysiological properties of the heart conduction system in patients with unexplained polymorphic ventricular tachycardia (VT) and/or ventricular fibrillation (VF), in patients with specific genetic mutations regarding sudden cardiac death or sudden cardiac arrest, in their family members and in a control cohort. The electrophysiological properties will be measured with the relatively new technique ECG-Imaging (ECGI).

Also a National Dutch registry for patients with unexplained polymorphic VT and/or VF and their family members will be created.

By combining the data from the registry and the results of ECGI, The investigators hope to identity risk markers for patients at higher risk for apparently idiopathic ventricular fibrillation, and use these for an adapted flow chart for the 'general'population of patients at risk for unexplained polymorphic VT and/or VF. The investigators aim to be able to identify patients before the first arrhythmic event, and aim for better treatment strategies in the future.

Detailed description: ECGI combines electrical body-surface mapping with 256 electrodes placed on the thorax with a CT-scan obtaining the anatomy of the heart and torso, hereby able to reconstruct local electrograms, activation and recovery times. In recent research, ECGI provided numerous extra insights into normal cardiac electrophysiology, but also electrophysiological disorders and disease. The results strongly suggest that ECGI can play a pivotal role in further characterizing arrhythmia mechanisms, therefore could do so for polymorphic VT or idiopathic VF leading to diagnosis and treatment improvement. Moreover, ECGI seems to have the potential to detect arrhythmogenic substrate in individuals before their first event, offering the possibility to diagnose and treat patients before sudden cardiac arrest occurs.

In the VIGILANCE study:

1. ECGI will be used to noninvasively characterize the epicardial electrophysiological substrate and triggers of:

   * Patients with unexplained polymorphic VT and VF,
   * Index patients of family cohorts with a specific genetic mutation related to arrhythmogenesis, at high risk for unexplained polymorphic VT and/or VF.
   * Family members,
   * A control cohort. Results will be evaluated for risk stratification.
2. All unexplained polymorphic VT and/or VF patients and their family members will be asked to participate in a National Dutch registry, and these date will be analysed to determine their prognostic value in terms of arrhythmia risk

Eligibility criteria: Inclusion Criteria:

In order to be eligible to participate in this study, a subject must be ≥ 18 years old and meet one of the following criteria:

* All unexplained polymorphic VT or VF survivors in whom known structural myocardial, respiratory, metabolic and toxicological causes have been excluded through clinical evaluation", with/without a genetic mutation. NB. If results of a diagnostic tests show minor abnormalities but insufficient for a specific diagnosis, this is no exclusion criterion.
* Selected family members of these patients\*
* Control subjects with structurally normal hearts with a clinical indication for a cardiac CT scan.

  * All 1st and 2nd degree family members being in contact with the cardiologist/treating physician as part of cascade screening will be contacted as described in chapter 11.2.2.

Family members must be in adequate health to be able to travel to the hospital for research purposes.

3rd degree family members can also be contacted as described in chapter 11.2.2 if at least one of the following criteria is met:

* The family member has the same genetic mutation as index patient, or;
* The family member has demonstrated ventricular arrhythmias, or;
* The clinician has a very strong suspicion of ventricular arrhythmias in the family member.

Exclusion Criteria:

A potential subject who meets any of the following criteria will be excluded from participation in this study:

* A known strong reaction against electrode attachment or contrast agent.
* Any serious medical condition, which in the opinion of the investigator, may adversely affect the safety and/or effectiveness of the participant or the study.
* Pregnancy, nursing or planning to be pregnant.
* Subject has an estimated glomerular filtration rate (eGFR) of \<30mL/min/1.73m2

  , using the MDRD calculation
* Unability to give informed consent.
* Family members of patients with unexplained polymorphic VT/VF, who have severe cardiac abnormalities and/or disease not related to the symptoms or phenotype of the index patient, and which may have a negative influence on results of ECGI according to local investigators.

Primary outcomes:
measure: ECG-Imaging outcome: epicardial potentials
timeFrame: 3 years
measure: ECG-Imaging outcome: activation and repolarization maps
timeFrame: 3 years
Secondary outcomes:
measure: (Possible) Prognostic risk factors for recurrent ventricular arrhythmias
timeFrame: 3 years
measure: Recurrence of ventricular arrhythmias
timeFrame: 3 years
Other outcomes:
Locations:
city: Maastricht
country: Netherlands
facility: Maastricht Universite Medical Centre
state: Nederland
city: Amsterdam
country: Netherlands
facility: Amsterdam University medical Centre, location AMC
city: Utrecht
country: Netherlands
facility: University Medical Centre Utrecht
Study officials:
affiliation: Maastricht University Medical Centre
name: Paul Volders, MD, PhD
role: PRINCIPAL_INVESTIGATOR
References: