Clinical trial NCT03707015: Internal Limiting Membrane Flap in the Management of Retinal Detachment Due to Paracentral Retinal Breaks
Official title: Internal Limiting Membrane Flap in the Management of Retinal Detachment Due to Paracentral Retinal Breaks
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Retinal Detachment
Surgery
Keywords: Retinal Detachment; internal limiting membrane flap; retinal paracentral breaks
Lead sponsor: Changhua Christian Hospital
Sponsor class: OTHER
First posted: 2018-10-16
Enrollment: 9
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: CASE_ONLY
Time perspective: RETROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: We included patients with retinal detachment and posterior paracentral retinal breaks located within the equator from January 2017 to January 2018. Eyes with macular hole were excluded. All of the cases underwent standard pars plana vitrectomy using the ILM flap technique, accompanied by extended gas tamponade without laser retinopexy

Brief summary: To describe the technique and outcomes of using either inverted or free internal limiting membrane flap in the management of retinal detachment due to paracentral retinal breaks.

Detailed description: This retrospective observational case series includes nine patients received surgery for retinal detachment due to paracentral retinal breaks developed either from primary rhegmatogenous orgin, or secondary iatrogenic retinal breaks after prior membrane peeling or during surgery for tractional retinal detachment. Either inverted or free internal limiting membrane flaps were inserted in the identified breaks, followed by air fluid exchange and gas tamponade. Visual acuity and structural changes were evaluated.

Eligibility criteria: Inclusion Criteria:

* Patients with retinal detachment and posterior paracentral retinal breaks located within the equator from January 2017 to January 2018

Exclusion Criteria:

* Patient with macular hole
* Patient with other ocular diseases including ocular hypertension, optic nerve atrophy, glaucoma or chronic uveitis

Primary outcomes:
measure: re-attachment rate of retinal detachment
timeFrame: within 3 months postoperatively
Secondary outcomes:
measure: visual acuity
timeFrame: within 3 months postoperatively
Other outcomes:
Locations:
Study officials:
affiliation: Changhua Christian Hospital
name: San-Ni Chen, M.D
role: PRINCIPAL_INVESTIGATOR
References:
citation: Chen SN, Yang CM. Inverted Internal Limiting Membrane Insertion for Macular Hole-Associated Retinal Detachment in High Myopia. Am J Ophthalmol. 2016 Feb;162:99-106.e1. doi: 10.1016/j.ajo.2015.11.013. Epub 2015 Nov 12.
citation: Chen SN, Hsieh YT, Yang CM. Multiple Free Internal Limiting Membrane Flap Insertion in the Treatment of Macular Hole-Associated Retinal Detachment in High Myopia. Ophthalmologica. 2018;240(3):143-149. doi: 10.1159/000487337. Epub 2018 Jun 6.
citation: Chen YC, Yang CM, Chen SN. Internal Limiting Membrane Flap in the Management of Retinal Detachment due to Paracentral Retinal Breaks. J Ophthalmol. 2019 Jan 21;2019:4303056. doi: 10.1155/2019/4303056. eCollection 2019.