Clinical trial NCT05317416: Study With Elranatamab Versus Lenalidomide in Patients With Newly Diagnosed Multiple Myeloma After Transplant
Official title: A RANDOMIZED, 2-ARM, PHASE 3 STUDY OF ELRANATAMAB (PF-06863135) VERSUS LENALIDOMIDE IN PATIENTS WITH NEWLY DIAGNOSED MULTIPLE MYELOMA AFTER UNDERGOING AUTOLOGOUS STEM-CELL TRANSPLANTATION
Study type: INTERVENTIONAL
Overall status: RECRUITING
Phase: PHASE3
Conditions: Multiple Myeloma
Keywords: BCMA
Multiple Myeloma
Newly diagnosed
Elranatamab
Targeted T-cell
MagnetisMM
MM7
Phase 3
B-cell Maturation Antigen
monoclonal antibody
Stem cell transplant
Autologous stem cell transplant (ASCT)
Hematologic disease
Minimum residual disease
Lenalidomide
Lead sponsor: Pfizer
Sponsor class: INDUSTRY
First posted: 2022-04-07
Enrollment: 760
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The purpose of this study is to evaluate whether elranatamab monotherapy can provide clinical benefit compared to lenalidomide monotherapy (control) in participants with newly diagnosed multiple myeloma after undergoing autologous stem cell transplant. In Part 1 and Part 2 of the study, participants in the study will either receive elranatamab (arm A and C) as an injection under the skin at the study clinic or lenalidomide orally once daily at home (arm B). Participation in the study will be approximately five years

Detailed description: Elranatamab is a bispecific antibody: binding of elranatamab to CD3-expressing T-cells and BCMA-expressing multiple myeloma cells causes targeted T-cell-mediated cytotoxicity.

Eligibility criteria: Inclusion Criteria:

* Diagnosis of MM as defined according to IMWG criteria (Rajkumar, 2014) with measurable disease at diagnosis
* Part 1 patients must be MRD positive, Part 2 patients can be MRD negative or MRD positive
* History of induction therapy for newly diagnosed MM, followed by high dose therapy and autologous stem cell transplant. Randomization must occur within 120 days from the stem cell transplant. For participants who receive consolidation therapy after ASCT, randomization must occur within 60 days of consolidation and within 7 months from ASCT.
* Partial Response or better according to IMWG criteria at the time of randomization
* Must have an archival bone marrow aspirate sample(s) to identify the dominant malignant (index) clone by central laboratory NGS test (ClonoSEQ assay) that is used to track MRD status. This sample should preferably be collected before induction treatment (eg, at diagnosis) or before transplant.
* ECOG performance status ≤1
* Resolved acute effects of any prior therapy to baseline severity or CTCAE Grade ≤ 1
* Not pregnant and willing to use contraception

Exclusion Criteria:

* Plasma cell leukemia
* Amyloidosis, Waldenström's macroglobulinemia
* POEMS syndrome
* Known active CNS involvement or clinical signs of myelomatous meningeal involvement
* Previous MM maintenance treatment
* Prior treatment with BCMA targeted therapy
* Any other active malignancy within 3 years prior to enrollment, except for adequately treated basal cell or squamous cell skin cancer, or carcinoma in situ
* Active, uncontrolled bacterial, fungal, or viral infection, including (but not limited to) HBV, HCV, and known HIV or AIDS-related illness
* Previous administration with an investigational drug or vaccine within 30 days (or as determined by the local requirement) or 5 half-lives preceding the first dose of study intervention used in this study (whichever is longer)

Primary outcomes:
measure: Progression Free Survival
timeFrame: Assessed for up to approximately 5 years
Secondary outcomes:
measure: Overall Survival
timeFrame: Assessed for up to approximately 5 years
measure: Minimal Residual Disease negativity rate
timeFrame: 12 months after randomization
measure: Sustained MRD negativity rate
timeFrame: 24 months after randomization
measure: Progression Free Survival
timeFrame: Assessed for up to approximately 5 years
measure: Overall minimal residual disease negativity rate
timeFrame: Assessed for up to approximately 5 years
measure: Duration of minimal residual disease negativity
timeFrame: Assessed for up to approximately 5 years
measure: Sustained minimal residual disease negativity rate
timeFrame: Assessed for up to approximately 5 years
measure: Complete response rate
timeFrame: Assessed for up to approximately 5 years
measure: Duration of complete response
timeFrame: Assessed for up to approximately 5 years
measure: Frequency of adverse events
timeFrame: Up to 90 days after last dose
measure: Frequency of laboratory abnormalities
timeFrame: Assessed for up to approximately 5 years
measure: Pre-dose concentrations of elranatamab
timeFrame: Assessed for up to approximately 5 years
measure: Post-dose concentrations of elranatamab
timeFrame: Assessed for up to approximately 5 years
measure: Incidence and titers of Anti-Drug Antibody and Neutralizing Antibody against elranatamab
timeFrame: Assessed for up to approximately 5 years
measure: Health-related quality of life by European Organization for Research and Treatment of Cancer Quality of Life Questionnaire - Core 30
timeFrame: Assessed for up to approximately 5 years
measure: Health-related quality of life by European Organization for Research and Treatment of Cancer Quality of Life Questionnaire - Myeloma 20
timeFrame: Assessed for up to approximately 5 years
measure: Progression Free Survival 2
timeFrame: Assessed for up to approximately 5 years
Other outcomes:
Locations:
city: Gilbert
country: United States
facility: Banner Gateway Medical Center
state: Arizona
city: Gilbert
country: United States
facility: Banner MD Anderson Cancer Center
state: Arizona
city: Los Angeles
country: United States
facility: Ronald Reagan UCLA Medical Center
state: California
city: Los Angeles
country: United States
facility: UCLA Hematology/Oncology - Westwood (Building 200 Suite 120)
state: California
city: Los Angeles
country: United States
facility: UCLA Hematology/Oncology - Santa Monica
state: California
city: Washington
country: United States
facility: Georgetown University Medical Center
state: District of Columbia
city: Miami
country: United States
facility: Miami Cancer Institute at Baptist Health, Inc.
state: Florida
city: Atlanta
country: United States
facility: Emory University Hospital Midtown
state: Georgia
city: Atlanta
country: United States
facility: Emory University Hospital
state: Georgia
city: Atlanta
country: United States
facility: Investigational Drug Service, Emory University Clinic
state: Georgia
city: Atlanta
country: United States
facility: Winship Cancer Institute, Emory University
state: Georgia
city: Maywood
country: United States
facility: Loyola University Chicago
state: Illinois
city: Leawood
country: United States
facility: Ascentist Doctor Hospital
state: Kansas
city: Merriam
country: United States
facility: American Oncology Partners, P.A. dba MidAmerica Cancer Care, LLC
state: Kansas
city: Mission
country: United States
facility: O'Brien Pharmacy
state: Kansas
city: Ann Arbor
country: United States
facility: University of Michigan
state: Michigan
city: Jackson
country: United States
facility: University Of Mississippi Medical Center
state: Mississippi
city: Jackson
country: United States
facility: University of Mississippi Medical Center
state: Mississippi
city: Kansas City
country: United States
facility: American Oncology Partners, P.A. Dba MidAmerica Cancer Care
state: Missouri
city: Lebanon
country: United States
facility: Dartmouth-Hitchcock Medical Center
state: New Hampshire
city: Hawthorne
country: United States
facility: WMCHealth Advanced Physician Services
state: New York
city: Valhalla
country: United States
facility: Westchester Medical Center
state: New York
city: Cleveland
country: United States
facility: Cleveland Clinic
state: Ohio
city: Columbus
country: United States
facility: OhioHealth Arthur G.H. Bing, MD, Cancer Center
state: Ohio
city: Columbus
country: United States
facility: OhioHealth Research Institute
state: Ohio
city: Columbus
country: United States
facility: OhioHealth Riverside Methodist Hospital
state: Ohio
city: Dallas
country: United States
facility: Baylor University Medical Center
state: Texas
city: Temple
country: United States
facility: Baylor Scott & White Medical Center - Temple
state: Texas
city: Camperdown
country: Australia
facility: Royal Prince Alfred Hospital
state: New South Wales
city: Nowra
country: Australia
facility: Shoalhaven District Memorial Hospital
state: New South Wales
city: Westmead
country: Australia
facility: Westmead Hospital
state: New South Wales
city: Wollongong
country: Australia
facility: Wollongong Hospital
state: New South Wales
city: Benowa
country: Australia
facility: Pindara Private Hospital
state: Queensland
city: Clayfield
country: Australia
facility: QScan Radiology Clinics
state: Queensland
city: Woolloongabba
country: Australia
facility: Princess Alexandra Hospital
state: Queensland
city: East Melbourne
country: Australia
facility: Epworth Healthcare
state: Victoria
city: East Melbourne
country: Australia
facility: Precision Haematology
state: Victoria
city: Fitzroy
country: Australia
facility: St Vincent's Hospital (Melbourne)
state: Victoria
city: Richmond
country: Australia
facility: Slade Pharmacy
city: Vienna
country: Austria
facility: Medizinische Universität Wien
state: Wien
city: Vienna
country: Austria
facility: Hanusch-Krankenhaus
city: Wien
country: Austria
facility: Medizinische Universität Wien
city: Anderlecht
country: Belgium
facility: Institut Jules Bordet
state: Bruxelles-capitale, Région DE
city: Charleroi
country: Belgium
facility: Grand Hôpital de Charleroi
state: Hainaut
city: Yvoir
country: Belgium
facility: Université Catholique de Louvain-Namur - Centre Hospitalier Universitaire Dinant-Godinne - Site Godi
state: Namur
city: Gent
country: Belgium
facility: UZ Gent
state: Oost-vlaanderen
city: Antwerpen
country: Belgium
facility: ZNA Middelheim
city: Antwerpen
country: Belgium
facility: Zna Cadix
city: Brussel
country: Belgium
facility: UZ Brussel
city: Salvador
country: Brazil
facility: Instituto D'Or de Pesquisa e Ensino (IDOR) - Filial Salvador
state: Bahia
city: Porto Alegre
country: Brazil
facility: Centro Gaucho Integrado De Oncologia, Hematologia, Ensino E Pesquisa
state: RIO Grande DO SUL
city: Porto Alegre
country: Brazil
facility: Centro de Pesquisa Clínica - Área Administrativa
state: RIO Grande DO SUL
city: Porto Alegre
country: Brazil
facility: Hospital Mae de Deus
state: RIO Grande DO SUL
city: Jaú
country: Brazil
facility: Hospital Amaral Carvalho
state: SÃO Paulo
city: Ribeirão Preto
country: Brazil
facility: Hospital das Clínicas da Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo (USP)
state: SÃO Paulo
city: Sao Paulo
country: Brazil
facility: BP - A Beneficencia Portuguesa de São Paulo
state: SÃO Paulo
city: SP
country: Brazil
facility: Clínica Médica São Germano LTDA
state: SÃO Paulo
city: Jaú
country: Brazil
facility: Fundação Doutor Amaral Carvalho
city: Rio de Janeiro
country: Brazil
facility: Américas Medical City
city: Rio de Janeiro
country: Brazil
facility: Instituto de Educação, Pesquisa e Gestão em Saúde
city: São Paulo
country: Brazil
facility: ESHO Empresa de Serviços Hospitalares S.A/ Hospital Samaritano de Higienópolis
city: São Paulo
country: Brazil
facility: HU UNIFESP / SPDM - Hospital São Paulo
city: São Paulo
country: Brazil
facility: Universidade Federal de Sao Paulo
city: São Paulo
country: Brazil
facility: Hospital Japonês Santa Cruz
city: São Paulo
country: Brazil
facility: Clínica Médica São Germano S/S Ltda
city: Calgary
country: Canada
facility: Arthur J.E. Child Comprehensive Cancer Centre
state: Alberta
city: Fredericton
country: Canada
facility: Dr. Everett Chalmers Regional Hospital
state: New Brunswick
city: Saint John
country: Canada
facility: Saint John Regional Hospital
state: New Brunswick
city: Hamilton
country: Canada
facility: Hamilton Health Sciences Corporation
state: Ontario
city: Toronto
country: Canada
facility: Princess Margaret Cancer Centre
state: Ontario
city: Windsor
country: Canada
facility: Windsor Regional Hospital Cancer Program
state: Ontario
city: Montreal
country: Canada
facility: Centre Integre Universitaire de la Santé et de Services Sociaux de l'Est-de-l'ile-de-Montreal,
state: Quebec
city: Montreal
country: Canada
facility: McGill University Health Centre
state: Quebec
city: Montreal
country: Canada
facility: Centre intégré universitaire de santé et de services sociaux du Nord-de-l'Île-de-Montréal (CIUSSS NÎ
state: Quebec
city: Guangzhou
country: China
facility: Sun Yat-sen University Cancer Center
state: Guangdong
city: Tianjin
country: China
facility: Institute of hematology&blood disease hospital
state: Tianjin
city: Wenzhou
country: China
facility: The First Affiliated Hospital of Wenzhou Medical University
state: Zhejiang
city: Brno
country: Czechia
facility: Fakultní nemocnice Brno Bohunice
state: Brno-město
city: Hradec Kralove
country: Czechia
facility: Fakultni nemocnice Hradec Kralove
state: Hradec Králové
city: Ostrava
country: Czechia
facility: Fakultni nemocnice Ostrava
state: Moravskoslezský KRAJ
city: Olomouc
country: Czechia
facility: Fakultni nemocnice Olomouc
city: Praha 2
country: Czechia
facility: Vseobecna fakultni nemocnice v Praze
city: Oulu
country: Finland
facility: Oulun yliopistollinen sairaala
state: Pohjois-pohjanmaa
city: Helsinki
country: Finland
facility: Helsinki University Hospital - Comprehensive Cancer Center (HYKS - Syöpäkeskus)
state: Uusimaa
city: Turku
country: Finland
facility: Turku University Hospital
state: Varsinais-suomi
city: Toulouse
country: France
facility: Institut Universitaire du Cancer Toulouse - Oncopole - CHU de TOULOUSE
state: Haute-garonne
city: Paris
country: France
facility: Pitie Salpetriere University Hospital
state: Orne
city: Villejuif
country: France
facility: Gustave Roussy
state: Val-de-marne
city: Poitiers
country: France
facility: Centre Hospitalier Universitaire de Poitiers
state: Vienne
city: La Tronche
country: France
facility: Chu Grenoble Alpes
city: Lille
country: France
facility: Hopital Claude Huriez - CHU de Lille
city: Paris Cedex 12
country: France
facility: Hôpital Saint Antoine
city: Pierre Benite
country: France
facility: Hopital Lyon Sud
city: Tours
country: France
facility: Centre Hospitalier Régional Universitaire de Tours - Hôpital Bretonneau
city: Würzburg
country: Germany
facility: Universitätsklinikum Würzburg
state: Bayern
city: Mainz
country: Germany
facility: Universitätsmedizin Johannes Gutenberg Universität Mainz
state: Rheinland-pfalz
city: Leipzig
country: Germany
facility: Universitätsklinikum Leipzig
state: Sachsen
city: Kiel
country: Germany
facility: Universitaetsklinikum Schleswig-Holstein Campus Kiel
state: Schleswig-holstein
city: Berlin
country: Germany
facility: Charite Universitätsmedizin Berlin Campus Benjamin Franklin
city: Chemnitz
country: Germany
facility: Klinikum Chemnitz gGMbH
city: Essen
country: Germany
facility: Universitätsklinikum Essen
city: München
country: Germany
facility: Klinikum rechts der Isar der Technischen Universität München
city: Athens
country: Greece
facility: Alexandra General Hospital of Athens
state: Attikí
city: Thessaloniki
country: Greece
facility: Theageneio Cancer Hospital of Thessaloniki
state: Kentrikí Makedonía
city: Ioannina
country: Greece
facility: University Hospital of Ioannina
state: Ípeiros
city: Kaposvár
country: Hungary
facility: Somogy Megyei Kaposi Mór Oktató Kórház
state: Somogy
city: Budapest
country: Hungary
facility: Semmelweis University
city: Budapest
country: Hungary
facility: Dél-Pesti Centrumkórház
city: Debrecen
country: Hungary
facility: Debreceni Egyetem Klinikai Kozpont
city: Nyíregyháza
country: Hungary
facility: Szabolcs-Szatmár-Bereg Megyei Kórházak és Egyetemi Oktatókórház, Jósa András Oktatókórház
city: Gurugram
country: India
facility: Artemis hospital
state: Haryana
city: Gurugram
country: India
facility: Medanta-The Medicity
state: Haryana
city: Gurugram
country: India
facility: Fortis Memorial Research Institute
state: Haryana
city: Dehradun
country: India
facility: Himalayan Institute Hospital Trust University
state: Uttarakhand
city: Kolkata
country: India
facility: Tata Medical Center
state: WEST Bengal
city: Delhi
country: India
facility: Rajiv Gandhi Cancer Institute And Research Centre
city: Be'er Sheva
country: Israel
facility: Soroka Medical Center
state: Hadarom
city: Petah-Tikva
country: Israel
facility: Rabin Medical Center
state: Hamerkaz
city: Ramat Gan
country: Israel
facility: Sheba Medical Center
state: Hamerkaz
city: Haifa
country: Israel
facility: Rambam Health Care Campus
state: Hatsafon
city: Tel Aviv
country: Israel
facility: Tel-Aviv Sourasky Medical Center Dana-Dwek Children's Hospital
state: Tell Abīb
city: Jerusalem
country: Israel
facility: Shaare Zedek Medical Center
state: Yerushalayim
city: Jerusalem
country: Israel
facility: Hadassah Medical Center
state: Yerushalayim
city: Jerusalem
country: Israel
facility: Hadassah Mount Scopus Medical Center
state: Yerushalayim
city: Jerusalem
country: Israel
facility: Shaare Zedek Medical Center
city: Meldola
country: Italy
facility: IRCCS - Istituto Romagnolo per lo Studio dei Tumori (IRST) "Dino Amadori"
state: Emilia-romagna
city: Roma
country: Italy
facility: Fondazione Policlinico Universitario Agostino Gemelli
state: Lazio
city: Milano
country: Italy
facility: Fondazione IRCCS Cà Granda Ospedale Maggiore Policlinico
state: Lombardia
city: Catania
country: Italy
facility: Policlinico "G. Rodolico"
state: Sicilia
city: Siena
country: Italy
facility: Azienda Ospedaliero Universitaria Senese
state: Toscana
city: Ancona
country: Italy
facility: Azienda Ospedaliero Universitaria Ospedali Riuniti Umberto I - G.M. Lancisi - G. Salesi
city: Bologna
country: Italy
facility: IRCCS Azienda Ospedaliero-Universitaria di Bologna, Policlinico di Sant'Orsola
city: Roma
country: Italy
facility: AOU Policlinico Umberto I
city: Nagoya
country: Japan
facility: Nagoya City University Hospital
state: Aichi
city: Maebashi
country: Japan
facility: Gunma University Hospital
state: Gunma
city: Kobe-city
country: Japan
facility: Kobe City Medical Center General Hospital
state: Hyogo
city: Yahaba-cho
country: Japan
facility: Iwate Medical University Hospital
state: Iwate
city: Kyoto-shi
country: Japan
facility: University Hospital,Kyoto Prefectural University of Medicine
state: Kyoto
city: Sendai
country: Japan
facility: Tohoku University Hospital
state: Miyagi
city: Hamamatsu-shi
country: Japan
facility: Hamamatsu University Hospital
state: Shizuoka
city: Sunto-gun
country: Japan
facility: Shizuoka Cancer Center
state: Shizuoka
city: Bunkyo-ku
country: Japan
facility: Nippon Medical School Hospital
state: Tokyo
city: Kagoshima
country: Japan
facility: Kagoshima University Hospital
city: Kumamoto
country: Japan
facility: National Hospital Organization Kumamoto Medical Center
city: Kyoto
country: Japan
facility: University Hospital,Kyoto Prefectural University of Medicine
city: Okayama
country: Japan
facility: National Hospital Organization Okayama Medical Center
city: Osaka
country: Japan
facility: Osaka Metropolitan University Hospital
city: Tokyo
country: Japan
facility: Japanese Red Cross Medical Center
city: Yamagata
country: Japan
facility: Yamagata University Hospital
city: Namdong-gu
country: Korea, Republic of
facility: Gachon University Gil Medical Center
state: Incheon-gwangyeoksi [incheon]
city: Hwasun Gun
country: Korea, Republic of
facility: Chonnam National University Hwasun Hospital
state: Jeonranamdo
city: Seongnam
country: Korea, Republic of
facility: Seoul National University Bundang Hospital
state: Kyǒnggi-do
city: Busan
country: Korea, Republic of
facility: Pusan National University Hospital
state: Pusan-kwangyǒkshi
city: Seoul
country: Korea, Republic of
facility: Seoul National University Hospital
state: Seoul-teukbyeolsi [seoul]
city: Seoul
country: Korea, Republic of
facility: Samsung Medical Center
state: Seoul-teukbyeolsi [seoul]
city: Seoul
country: Korea, Republic of
facility: The Catholic Univ. of Korea Seoul St. Mary's Hospital(Seoul St. Mary's Hospital)
state: Seoul-teukbyeolsi [seoul]
city: Seoul
country: Korea, Republic of
facility: The Catholic Univ. of Korea Seoul St. Mary's Hospital
state: Seoul-teukbyeolsi [seoul]
city: Daegu
country: Korea, Republic of
facility: Kyungpook National University
state: Taegu-kwangyǒkshi
city: Jung-gu
country: Korea, Republic of
facility: Kyungpook National University Hospital
state: Taegu-kwangyǒkshi
city: Den Haag
country: Netherlands
facility: HagaZiekenhuis
state: Zuid-holland
city: Maastricht
country: Netherlands
facility: Maastricht Universitair Medisch Centrum
city: Zwolle
country: Netherlands
facility: Isala
city: Oslo
country: Norway
facility: Oslo Universitetssykehus Ullevål
city: Stavanger
country: Norway
facility: Stavanger Universitetssykehus
city: Skorzewo
country: Poland
facility: Centrum Medyczne Pratia Poznań
state: Wielkopolskie
city: Gdansk
country: Poland
facility: Uniwersyteckie Centrum Kliniczne,
city: Poznan
country: Poland
facility: Uniwersytecki Szpital Kliniczny w Poznaniu
city: Warszawa
country: Poland
facility: Uniwersyteckie Centrum Kliniczne WUM Centralny Szpital Kliniczny
city: Warszawa
country: Poland
facility: Narodowy Instytut Onkologii im. Marii Sklodowskiej-Curie - Panstwowy Instytut Badawczy
city: Wroclaw
country: Poland
facility: Uniwersytecki Szpital Kliniczny im. Jana Mikulicza-Radeckiego we Wroclawiu
city: Katowice
country: Poland
facility: Pratia Onkologia Katowice
state: Śląskie
city: Santiago de Compostela
country: Spain
facility: Complejo Hospitalario Universitario de Santiago
state: A Coruna
city: Barcelona
country: Spain
facility: Hospital Universitari Vall d'Hebron
state: Barcelona [barcelona]
city: L'Hospitalet Del Llobregat
country: Spain
facility: Institut Català d'Oncologia - L'Hospitalet
state: Barcelona [barcelona]
city: Terrassa
country: Spain
facility: Hospital Universitari Mutua Terrassa
state: Barcelona [barcelona]
city: Badalona
country: Spain
facility: Institut Catala d' Oncologia. Hospital Germans Trias i Pujol
state: Barcelona
city: Terrassa
country: Spain
facility: Hospital Universitari Mutua Terrassa
state: Barcelona
city: Salamanca
country: Spain
facility: Hospital Universitario de Salamanca
state: Castilla Y LEÓN
city: Barcelona
country: Spain
facility: Hospital Clínic de Barcelona
state: Catalunya [cataluña]
city: Madrid
country: Spain
facility: Clinica Universidad de Navarra
state: Madrid, Comunidad DE
city: Madrid
country: Spain
facility: Hospital Universitario La Paz
state: Madrid, Comunidad DE
city: Pozuelo de Alarcon
country: Spain
facility: Hospital Universitario Quironsalud Madrid
state: Madrid
city: Cáceres
country: Spain
facility: Hospital San Pedro de Alcántara
city: Gerona
country: Spain
facility: Institut Catala Oncologia - Hospital Universitari de Girona Dr Josep Trueta
city: Madrid
country: Spain
facility: Hospital La Princesa
city: Madrid
country: Spain
facility: Hospital General Universitario Gregorio Marañon
city: Madrid
country: Spain
facility: Hospital Universitario 12 de Octubre
city: Madrid
country: Spain
facility: Hospital Universitario HM Sanchinarro
city: Salamanca
country: Spain
facility: Hospital Universitario de Salamanca - Complejo Asistencial Universitario de Salamanca
city: València
country: Spain
facility: Hospital Universitari i Politecnic La Fe
city: Helsingborg
country: Sweden
facility: Helsingborgs Lasarett
state: Skåne LÄN [se-12]
city: Stockholm
country: Sweden
facility: Karolinska Universitetssjukhuset Huddinge
state: Stockholms LÄN [se-01]
city: Borås
country: Sweden
facility: Södra Älvsborgs Sjukhus Borås
state: Västra Götalands LÄN [se-14]
city: Falun
country: Sweden
facility: Falu Lasarett
city: Örebro
country: Sweden
facility: Universitetssjukhuset Örebro
state: Örebro LÄN [se-18]
city: Linköping
country: Sweden
facility: Universitetssjukhuset i Linköping
state: Östergötlands LÄN [se-05]
city: Lausanne
country: Switzerland
facility: CHUV (centre hospitalier universitaire vaudois)
state: Vaud
city: Zürich
country: Switzerland
facility: UniversitätsSpital Zürich
state: Zürich (DE)
city: Baden
country: Switzerland
facility: Kantonsspital Baden
city: Berne
country: Switzerland
facility: Inselspital Bern
city: Winterthur
country: Switzerland
facility: Kantonsspital Winterthur
city: Taichung
country: Taiwan
facility: China Medical University Hospital
city: Taichung
country: Taiwan
facility: Taichung Veterans General Hospital
city: Taipei
country: Taiwan
facility: National Taiwan University Hospital
city: Taipei
country: Taiwan
facility: Taipei Veterans General Hospital
city: Taoyuan
country: Taiwan
facility: Chang Gung Medical Foundation-Linkou Branch
city: İstanbul
country: Turkey
facility: Medipol Mega Universite Hastanesi
state: İ̇stanbul
city: İstanbul
country: Turkey
facility: Sisli Florence Nightingale Hastanesi
state: İ̇stanbul
city: Izmir
country: Turkey
facility: Ege Universitesi Hastanesi
state: İ̇zmir
city: İzmir
country: Turkey
facility: Dokuz Eylul Universitesi Hastanesi
state: İ̇zmir
city: Ankara
country: Turkey
facility: Ankara University Health Practice and Research Hospitals
city: Ankara
country: Turkey
facility: Dr. Abdurrahman Yurtaslan Ankara Onkoloji Egitim ve Arastırma Hastanesi
city: Aydin
country: Turkey
facility: Aydın Adnan Menderes Universitesi Hastanesi
city: Kayseri
country: Turkey
facility: Erciyes Universitesi Tıp Fakultesi Hastaneleri
city: Kocaeli
country: Turkey
facility: Özel Anadolu Sağlık Merkezi
city: Cambridge
country: United Kingdom
facility: Addenbrooke's Hospital
state: Cambridgeshire
city: Birmingham
country: United Kingdom
facility: Queen Elizabeth Hospital Birmingham
state: England
city: Dewsbury
country: United Kingdom
facility: Dewsbury and District Hospital
state: Wakefield
city: Pontefract
country: United Kingdom
facility: Pontefract General Infirmary
state: Wakefield
city: Belfast
country: United Kingdom
facility: Belfast City Hospital
city: Glasgow
country: United Kingdom
facility: The Beatson West of Scotland Cancer Centre
city: Reading
country: United Kingdom
facility: Royal Berkshire Hospital
city: Wakefield
country: United Kingdom
facility: Pinderfields General Hospital
city: Wolverhampton
country: United Kingdom
facility: New Cross Hospital
Study officials:
affiliation: Pfizer
name: Pfizer CT.gov Call Center
role: STUDY_DIRECTOR
References: