Clinical trial NCT03303586: Effects of Compression Stockings in Asthma Symptoms at Night
Official title: Investigating the Effects of Wearing Compression Stockings to Improve Asthma Symptoms at Night
Study type: INTERVENTIONAL
Overall status: RECRUITING
Phase: NA
Conditions: Asthma
Keywords: Asthma
Fluid Shift
Compression stockings
intrathoracic airway narrowing
Lead sponsor: University Health Network, Toronto
Sponsor class: OTHER
First posted: 2017-10-06
Enrollment: 40
Sex: ALL
Minimum age (years): 20
Maximum age (years): 75
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: CROSSOVER
Intervention model description: Participants will be randomly assigned to wearing compression stockings for next two weeks or not wearing compression stockings for next two weeks, and crossed over.
Primary purpose: TREATMENT

Brief summary: Nocturnal worsening of asthma is common. It is characterized by overnight exacerbation of asthma symptoms such as shortness of breath, chest tightness, coughing, and wheezing, increased need of asthma medications and airway hyperresponsiveness, and decline in lung function (1). Nocturnal asthma has been attributed in part to circadian variations in lung function and airway inflammation. However, other factors including sleep, supine posture and lung volume may also contribute to nocturnal asthma. Current treatments often improve nighttime asthma symptoms. Nevertheless, nocturnal asthma is still common. Up to 2/3rd of asthma patients report nocturnal asthma symptoms, and many asthma related events occur at night, indicating poor asthma control. Results from an ongoing study suggest that in asthma while subjects were supine, fluid shifted out of the legs and accumulated in the thorax (rostral fluid shift) contributing to lower airway narrowing in asthma. A previou study has shown that wearing compression stockings during the day reduces fluid retention in the legs, reduces nocturnal rostral fluid shift out of the legs, and improves sleep apnea (2, 3). The aims of the proposed study is investigate whether off-the-shelf, below the knee compression stockings will attenuate nocturnal fluid shift and lower airway narrowing in asthma.


Eligibility criteria: Inclusion Criteria: non-smokers or former smokers (\<10 pack/year)

Exclusion Criteria: uncontrolled hypertension

Primary outcomes:
measure: Effect of wearing compression stockings on reducing rostral fluid shift during sleep and its effect in airway narrowing
timeFrame: After 2 weeks of the intervention
Secondary outcomes:
Other outcomes:
Locations:
city: Toronto
country: Canada
facility: Toronto Rehabilitation Institute (TRI)
state: Ontario
Study officials:
affiliation: Scientist
name: Azadeh Yadollahi
role: PRINCIPAL_INVESTIGATOR
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