Clinical trial NCT05980949: Open-Label Extension Study to Assess the Long-Term Safety and Tolerability of KarXT in Subjects With Psychosis Associated With Alzheimer's Disease (ADEPT-3)
Official title: A Phase 3 Global, Multicenter, Open-Label Extension Study to Assess the Long-Term Safety and Tolerability of KarXT in Subjects With Psychosis Associated With Alzheimer's Disease
Study type: INTERVENTIONAL
Overall status: RECRUITING
Phase: PHASE3
Conditions: Psychosis Associated With Alzheimer's Disease
Lead sponsor: Karuna Therapeutics
Sponsor class: INDUSTRY
First posted: 2023-08-08
Enrollment: 600
Sex: ALL
Minimum age (years): 55
Maximum age (years): 90
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: TREATMENT

Brief summary: This is a Phase 3 global, multicenter, 52-week, open-label extension (OLE) rollover study for subjects completing study CN012-0026, CN012-0027 or CN012-0056. Subjects (randomized or non-randomized) who complete the 38-week CN012-0026 study, 14-week CN012-0027 study or 14-week CN012-0056 study will be eligible to enroll in CN012-0028.

The primary objective of the study is to assess the long-term safety and tolerability of KarXT in subjects with psychosis associated with Alzheimer's Disease.


Eligibility criteria: Key Inclusion Criteria:

* Must have completed study CN012-0026, CN012-0027 or CN012-0056.
* Subject was aged 55 to 90 years, inclusive, at the time of enrollment into the parent CN012-0026, CN012-0027 or CN012-0056 study.
* Can understand the nature of the study and protocol requirements and provide a signed informed consent or, if deemed not competent to provide informed consent, the subject's legally acceptable representative must provide informed consent, and the subject must provide informed assent before any study assessments are performed.
* At entry into this study, or any time during the study, if a subject needs to relocate from home or residential assisted-living facility to a nursing home facility, the Sponsor/Medical Monitor must approve the subject's participation in the study.
* Have an identified or proxy caregiver (spends approximately 10 hours/week with the subject).

Key Exclusion Criteria:

* Significant or severe medical conditions that, in the opinion of the Investigator, could jeopardize the safety of the subject, ability to complete or comply with the study procedures or validity of the study results.
* Clinically significant abnormalities, including any finding(s) from the ECG, laboratory tests, physical examination, or vital signs, at the EOT visit of Study CN012-0026, CN012-0027 or CN012-0056 that the Investigator, in consultation with the Medical Monitor, are considered to jeopardize the safety of the subject.
* Subjects participating in another investigational drug or device study or planning on participating in another clinical study during the duration of CN012-0028.

Primary outcomes:
measure: Incidence of treatment-emergent adverse events (TEAEs)
timeFrame: From initial dose through 14 days after the final dose (up to 54 weeks)
Secondary outcomes:
measure: Incidence of serious TEAEs
timeFrame: From initial dose through 14 days after the final dose (up to 54 weeks)
measure: Incidence of TEAEs leading to withdrawal
timeFrame: From initial dose through 14 days after the final dose (up to 54 weeks)
Other outcomes:
Locations:
city: Homewood
country: United States
facility: Local Institution - 1029
state: Alabama
city: Chandler
country: United States
facility: Local Institution - 1-13H98LK9
state: Arizona
city: Chandler
country: United States
facility: Local Institution - 1227
state: Arizona
city: Chandler
country: United States
facility: Local Institution - 1116
state: Arizona
city: Phoenix
country: United States
facility: Local Institution - 1217
state: Arizona
city: Phoenix
country: United States
facility: Local Institution - 1044
state: Arizona
city: Anaheim
country: United States
facility: Advanced Research Center, Inc.
state: California
city: Costa Mesa
country: United States
facility: Local Institution - 1001
state: California
city: Encino
country: United States
facility: Local Institution - 1151
state: California
city: Encino
country: United States
facility: Local Institution - 1033
state: California
city: Irvine
country: United States
facility: Local Institution - 1031
state: California
city: Lakewood
country: United States
facility: Local Institution - 1230
state: California
city: Lancaster
country: United States
facility: Local Institution - 1142
state: California
city: Los Alamitos
country: United States
facility: Local Institution - 1117
state: California
city: Los Angeles
country: United States
facility: Local Institution - 1226
state: California
city: Orange
country: United States
facility: Local Institution - 1228
state: California
city: Pasadena
country: United States
facility: Local Institution - 1043
state: California
city: Rancho Cucamonga
country: United States
facility: Local Institution - 1213
state: California
city: Sherman Oaks
country: United States
facility: California Neuroscience Research - CenExel - PPDS
state: California
city: Walnut Creek
country: United States
facility: Local Institution - 1007
state: California
city: Colorado Springs
country: United States
facility: Local Institution - 1014
state: Colorado
city: Farmington
country: United States
facility: Local Institution - 1222
state: Connecticut
city: Stamford
country: United States
facility: Local Institution - 1013
state: Connecticut
city: Atlantis
country: United States
facility: Local Institution - 1225
state: Florida
city: Boca Raton
country: United States
facility: Local Institution - 1011
state: Florida
city: Bonita Springs
country: United States
facility: Local Institution - 1020
state: Florida
city: Bradenton
country: United States
facility: Local Institution - 1015
state: Florida
city: Clermont
country: United States
facility: Local Institution - 1156
state: Florida
city: Clermont
country: United States
facility: Local Institution - 1048
state: Florida
city: Cutler Bay
country: United States
facility: JY Research Institute Inc
state: Florida
city: Daytona Beach
country: United States
facility: Arrow Clinical Trials
state: Florida
city: Deerfield Beach
country: United States
facility: Local Institution - 1224
state: Florida
city: Delray Beach
country: United States
facility: Local Institution - 1162
state: Florida
city: Doral
country: United States
facility: Integrity Clinical Research, LLC - 8000 NW 21st St
state: Florida
city: Doral
country: United States
facility: Betancourt Research Services
state: Florida
city: Fort Myers
country: United States
facility: Local Institution - 1165
state: Florida
city: Hialeah
country: United States
facility: Superior Associates in Research LLC
state: Florida
city: Hialeah
country: United States
facility: Direct Helpers Research Center
state: Florida
city: Hialeah
country: United States
facility: New Life Medical Research Center -3750 W 16th Ave
state: Florida
city: Hialeah
country: United States
facility: Local Institution - 1046
state: Florida
city: Hialeah
country: United States
facility: Local Institution - 1052
state: Florida
city: Hialeah
country: United States
facility: Local Institution - 1-13JED81K
state: Florida
city: Hialeah
country: United States
facility: Local Institution - 1237
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city: Hialeah
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state: Florida
city: Homestead
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state: Florida
city: Homestead
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facility: Coral Clinic Research
state: Florida
city: Homestead
country: United States
facility: Homestead Associates in Research Inc-30328 Old Dixie Hwy
state: Florida
city: Largo
country: United States
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city: Maitland
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state: Florida
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facility: New Med Research
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city: Miami Lakes
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facility: San Marcus Research Clinic Inc
state: Florida
city: Miami Lakes
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state: Florida
city: Miami Lakes
country: United States
facility: Local Institution - 1209
state: Florida
city: Miami Springs
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facility: Ocean Blue Medical Research Center Inc
state: Florida
city: Miami Springs
country: United States
facility: Local Institution - 1053
state: Florida
city: Miami
country: United States
facility: Premier Clinical Research Institute - Miami - ClinEdge - PPDS
state: Florida
city: Miami
country: United States
facility: Angels Clinical Research Institute - Miami
state: Florida
city: Miami
country: United States
facility: Local Institution - 1005
state: Florida
city: Miami
country: United States
facility: Dade Research Center
state: Florida
city: Miami
country: United States
facility: CCM Clinical Research Group
state: Florida
city: Miami
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facility: Wellness Research Center Inc - Miami
state: Florida
city: Miami
country: United States
facility: Local Institution - 1236
state: Florida
city: Miami
country: United States
facility: Floridian Neuroscience Institute-1901 SW 1 St
state: Florida
city: Miami
country: United States
facility: Local Institution - 1010
state: Florida
city: Miami
country: United States
facility: MedOne Clinical Research LLC
state: Florida
city: Miami
country: United States
facility: Allied Biomedical Research Institute
state: Florida
city: Miami
country: United States
facility: My Community Research Center, Inc - 7480 Bird Rd
state: Florida
city: Miami
country: United States
facility: Future Care Solution LLC
state: Florida
city: Miami
country: United States
facility: Reliant Medical Research
state: Florida
city: Miami
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facility: Local Institution - 1006
state: Florida
city: Miami
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facility: Florida Research Center, Inc.
state: Florida
city: Miami
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facility: US Associates in Research Inc
state: Florida
city: Miami
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facility: Serenity Research Center
state: Florida
city: Miami
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facility: IMIC LLC- 9380 SW 150th Str
state: Florida
city: Miami
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facility: New Gen Health
state: Florida
city: Miami
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facility: Floridian Research Institute-1021 Ives Dairy Rd
state: Florida
city: Miami
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facility: High Quality Research
state: Florida
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state: Florida
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facility: ONHEALTH Research Center
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state: Florida
city: Orlando
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facility: Combined Research Orlando Phase I-IV
state: Florida
city: Ormond Beach
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facility: Neurology Associates of Ormond Beach
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city: Pensacola
country: United States
facility: Local Institution - 1012
state: Florida
city: Port Orange
country: United States
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state: Florida
city: Port Orange
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state: Florida
city: Saint Petersburg
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city: Sweetwater
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facility: Cordova Research Institute- Sweetwater
state: Florida
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state: Florida
city: Tampa
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facility: Guardian Angel Research - ClinEdge - PPDS
state: Florida
city: Tampa
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facility: Angels Clinical Research Institute Tampa
state: Florida
city: Tampa
country: United States
facility: Interventional Psychiatry of Tampa Bay
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city: The Villages
country: United States
facility: Local Institution - 1040
state: Florida
city: Viera
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state: Florida
city: West Palm Beach
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state: Florida
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state: Georgia
city: Decatur
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state: Michigan
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state: New York
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state: New York
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state: New York
city: Woodmere
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facility: Five Towns Neurology PC -Woodmere - 923 Broadway
state: New York
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state: North Carolina
city: Matthews
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state: North Carolina
city: Morehead City
country: United States
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state: North Carolina
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state: Ohio
city: Dayton
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state: Rhode Island
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state: South Carolina
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state: Tennessee
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facility: Horizon Clinical Research: Gill Neuroscience
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state: Texas
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state: Texas
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state: Texas
city: Houston
country: United States
facility: Clinical Trial Network - 7080 Southwest Fwy
state: Texas
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country: United States
facility: Local Institution - 1238
state: Texas
city: Red Oak
country: United States
facility: Local Institution - 1121
state: Texas
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country: United States
facility: Local Institution - 1134
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city: Ciudad Autónoma de Buenos Aires
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state: Buenos Aires
city: Ciudad Autónoma de Buenos Aires
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state: Buenos Aires
city: Ciudad Autónoma de Buenos Aires
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state: Brussels
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state: Vlaams Brabant
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state: West-Vlaanderen
city: Alken
country: Belgium
facility: Local Institution - 1-13JED87R
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city: Kortrijk
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state: Distrito Federal
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facility: Local Institution - 6202
state: SAO Paulo
city: São Paulo
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facility: Local Institution - 6206
state: SAO Paulo
city: São Paulo
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state: SAO Paulo
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state: SAO Paulo
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facility: Local Institution - 1-13J38ZRS
state: SAO Paulo
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facility: Local Institution - 6203
state: SAO Paulo
city: Rio de Janeiro
country: Brazil
facility: Local Institution - 1-13J338E3
city: Rio de Janeiro
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facility: Local Institution - 6204
city: Sofia
country: Bulgaria
facility: Medical Center Sveti Naum EOOD
state: Sofia-Grad
city: Sofia
country: Bulgaria
facility: Local Institution - 4505
state: Sofia-Grad
city: Sofia
country: Bulgaria
facility: Local Institution - 4502
state: Sofia-Grad
city: Sofia
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facility: Local Institution - 4506
state: Sofia-Grad
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facility: Medical Center Medconsult Pleven OOD
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state: Ontario
city: Whitby
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facility: Local Institution - 1604
state: Ontario
city: Montreal
country: Canada
facility: Local Institution - 1-12IYJCH7
state: Quebec
city: Verdun
country: Canada
facility: Local Institution - 1601
state: Quebec
city: Providencia
country: Chile
facility: Biomedica Research Group
state: Metropolitana
city: Antofagasta
country: Chile
facility: Psicomed Estudios Médicos Cía Ltda
city: Las Condes
country: Chile
facility: Especialidades Medicas L Y S
city: Hefei
country: China
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state: Anhui
city: Beijing
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state: Jiangsu
city: Nanchang
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facility: Shanghai Mental Health Center - PPDS
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state: Shanghai
city: Chengdu
country: China
facility: West China Hospital Sichuan University
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state: Zhejiang
city: Hangzhou
country: China
facility: Sir Run Run Shaw Hospital Zhejiang University School of Medicine - Qingchun Campus
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country: China
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state: Grad Zagreb
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country: Croatia
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state: Grad Zagreb
city: Zagreb
country: Croatia
facility: Local Institution - 4103
state: Grad Zagreb
city: Zagreb
country: Croatia
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state: Grad Zagreb
city: Zagreb
country: Croatia
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state: Grad Zagreb
city: Praha
country: Czechia
facility: CLINTRIAL s.r.o.
state: Praha, Hlavní Mesto
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country: Czechia
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city: Plzeň
country: Czechia
facility: A-SHINE s.r.o.
city: Praha 4
country: Czechia
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country: Czechia
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country: France
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country: France
facility: Local Institution - 2511
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country: France
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city: Rouen
country: France
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country: France
facility: Local Institution - 2513
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country: Germany
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state: Baden-Württemberg
city: Böblingen
country: Germany
facility: Local Institution - 2407
state: Baden-Württemberg
city: Bayreuth
country: Germany
facility: Local Institution - 2403
state: Bayern
city: Erbach
country: Germany
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state: Hessen
city: Erbach
country: Germany
facility: Local Institution - 2404
state: Hessen
city: Homburg
country: Germany
facility: Local Institution - 2402
state: Saarland
city: Frankfurt am Main
country: Germany
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city: Frankfurt am Main
country: Germany
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country: Greece
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city: Athina
country: Greece
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state: Attiki
city: Chaidari, Athens
country: Greece
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state: Attiki
city: Kalyftaki-N. Kifissia
country: Greece
facility: Local Institution - 4810
state: Attiki
city: Marousi
country: Greece
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state: Attiki
city: Heraklion
country: Greece
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country: Greece
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city: Pécs
country: Hungary
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state: Baranya
city: Szeged
country: Hungary
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state: Csongrád
city: Szeged
country: Hungary
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state: Csongrád
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country: Hungary
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city: Budapest
country: Hungary
facility: Local Institution - 4612
city: Gyongyos
country: Hungary
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city: Gyongyos
country: Hungary
facility: Local Institution - 4611
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country: Hungary
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country: India
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country: India
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city: Petah Tikva
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country: Israel
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country: Italy
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state: Lazio
city: Roma
country: Italy
facility: Local Institution - 2322
state: Lazio
city: Roma
country: Italy
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state: Lazio
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facility: Local Institution - 2320
state: Lazio
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state: Lazio
city: Brescia
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state: Lombardia
city: Brescia
country: Italy
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state: Lombardia
city: Milano
country: Italy
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state: Lombardia
city: Milano
country: Italy
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state: Lombardia
city: Baggiovara
country: Italy
facility: Local Institution - 2306
state: Modena
city: Ponderano (Biella)
country: Italy
facility: Local Institution - 2307
state: Piemonte
city: Rome
country: Italy
facility: Local Institution - 2321
state: Roma
city: Firenze
country: Italy
facility: Local Institution - 2308
state: Toscana
city: Monza
country: Italy
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city: Pisa
country: Italy
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city: Roma
country: Italy
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city: Roma
country: Italy
facility: Local Institution - 2309
city: Iizuka
country: Japan
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state: Fukuoka
city: Iizuka
country: Japan
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state: Fukuoka
city: Koriyama
country: Japan
facility: Local Institution - 7525
state: Fukushima
city: Sapporo
country: Japan
facility: Local Institution - 7522
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city: Himeji-Shi
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facility: Local Institution - 7526
state: Hyogo
city: Toride-shi
country: Japan
facility: Local Institution - 1-13H98LIT
state: Ibaraki
city: Toride-shi
country: Japan
facility: Local Institution - 7508
state: Ibaraki
city: Takamatsu-Shi
country: Japan
facility: Local Institution - 7514
state: Kagawa
city: Hadano
country: Japan
facility: Local Institution - 7505
state: Kanagawa
city: Kawasaki-Shi
country: Japan
facility: Local Institution - 7507
state: Kanagawa
city: Yokohama-Shi
country: Japan
facility: Local Institution - 7502
state: Kanagawa
city: Yokohama
country: Japan
facility: Local Institution - 7520
state: Kanagawa
city: Yokohama
country: Japan
facility: Local Institution - 7513
state: Kanagawa
city: Kyoto-Shi
country: Japan
facility: Local Institution - 7511
state: Kyoto
city: Tsu-Shi
country: Japan
facility: Local Institution - 7506
state: MIE
city: Sakai
country: Japan
facility: Local Institution - 7509
state: Osaka
city: Takatsuki
country: Japan
facility: Local Institution - 7501
state: Osaka
city: Yoshinogawa
country: Japan
facility: Local Institution - 7512
state: Tokushima
city: Hachioji
country: Japan
facility: Local Institution - 7518
state: Tokyo
city: Setagaya-Ku
country: Japan
facility: Local Institution - 7521
state: Tokyo
city: Setagaya-Ku
country: Japan
facility: Local Institution - 7519
state: Tokyo
city: Hiroshima
country: Japan
facility: Local Institution - 7516
city: Kumamoto
country: Japan
facility: Local Institution - 1-13H98LTZ
city: Kumamoto
country: Japan
facility: Local Institution - 7524
city: Tatebayashi
country: Japan
facility: Local Institution - 7523
city: Buk-gu
country: Korea, Republic of
facility: Local Institution - 7208
state: Daegu Gwang'yeogsi
city: Ansan-si
country: Korea, Republic of
facility: Local Institution - 7214
state: Gyeonggido
city: Seongnam-si
country: Korea, Republic of
facility: Local Institution - 7207
state: Gyeonggido
city: Incheon
country: Korea, Republic of
facility: Local Institution - 7205
state: Incheon Gwang'yeogsi
city: Seoul
country: Korea, Republic of
facility: Local Institution - 7213
state: Seoul Teugbyeolsi
city: Seoul
country: Korea, Republic of
facility: Local Institution - 7210
state: Seoul Teugbyeolsi
city: Seoul
country: Korea, Republic of
facility: Local Institution - 7215
state: Seoul Teugbyeolsi
city: Yeongdeungpo-Gu
country: Korea, Republic of
facility: Local Institution - 7212
state: Seoul Teugbyeolsi
city: Seongnam-si
country: Korea, Republic of
facility: Local Institution - 7202
city: Seoul
country: Korea, Republic of
facility: Seoul National University Hospital
city: Seoul
country: Korea, Republic of
facility: Local Institution - 7203
city: Seoul
country: Korea, Republic of
facility: Local Institution - 7201
city: Seoul
country: Korea, Republic of
facility: Local Institution - 7211
city: Zona Urbana Río Tijuana
country: Mexico
facility: Local Institution - 1504
state: BAJA California
city: Saltillo Centro
country: Mexico
facility: Hospital Universitario de Saltillo Dr Gonzalo Valdes Valdes
state: Coahuila
city: Zapopan
country: Mexico
facility: Local Institution - 1507
state: Jalisco
city: Monterrey
country: Mexico
facility: Local Institution - 1503
state: Nuevo LEON
city: Monterrey
country: Mexico
facility: Local Institution - 1505
state: Nuevo LEON
city: Culiacan
country: Mexico
facility: Neurociencias Estudios Clinicos S.C.
state: Sinaloa
city: Mexico
country: Mexico
facility: Local Institution - 1506
city: Miraflores
country: Peru
facility: Local Institution - 6102
state: Lima
city: Callao
country: Peru
facility: Local Institution - 6101
city: Wroclaw
country: Poland
facility: Local Institution - 4211
state: Dolnoslaskie
city: Lódz
country: Poland
facility: Osrodek Badan Klinicznych Appletreeclinics
state: Lódzkie
city: Gdansk
country: Poland
facility: Local Institution - 1-13JAX170
state: Pomorskie
city: Gdansk
country: Poland
facility: Local Institution - 4212
state: Pomorskie
city: Bydgoszcz
country: Poland
facility: Local Institution - 4204
city: Katowice
country: Poland
facility: Local Institution - 4208
city: Katowice
country: Poland
facility: Local Institution - 4205
city: Kielce
country: Poland
facility: Local Institution - 4213
city: Lodz
country: Poland
facility: Medycyna Milorzab sp. z o.o.
city: Lodz
country: Poland
facility: Local Institution - 4214
city: Lublin
country: Poland
facility: NZOZ NEUROMED M. I M. Nastaj Spolka Partnerska -Lublin
city: Poznan
country: Poland
facility: Local Institution - 4210
city: Siemianowice Śląskie
country: Poland
facility: Local Institution - 4209
city: Ścinawa
country: Poland
facility: Osrodek Badawczo Naukowo Dydaktyczny Chorób Otepiennych im Ksiedza Henryka Kardynala Gulbinowicza
city: Guimarães
country: Portugal
facility: Local Institution - 2701
state: Braga
city: Lisbon
country: Portugal
facility: Local Institution - 2704
state: Lisboa
city: Torres Vedras
country: Portugal
facility: Local Institution - 2702
state: Lisboa
city: Matosinhos
country: Portugal
facility: Local Institution - 2703
state: Porto
city: Lisboa
country: Portugal
facility: Local Institution - 2705
city: Lisboa
country: Portugal
facility: Local Institution - 2706
city: Bayamon
country: Puerto Rico
facility: Local Institution - 1303
city: Bayamon
country: Puerto Rico
facility: Local Institution - 1301
city: Carolina
country: Puerto Rico
facility: Local Institution - 1305
city: San Juan
country: Puerto Rico
facility: Local Institution - 1302
city: San Juan
country: Puerto Rico
facility: Local Institution - 1304
city: Oradea
country: Romania
facility: Local Institution - 4904
state: Bihor
city: Bucuresti
country: Romania
facility: Local Institution - 4906
city: Constanta
country: Romania
facility: Local Institution - 4902
city: Craiova
country: Romania
facility: Local Institution - 4903
city: Sibiu
country: Romania
facility: Local Institution - 4901
city: Beograd
country: Serbia
facility: Local Institution - 4307
state: Belgrade
city: Beograd
country: Serbia
facility: Local Institution - 4302
state: Belgrade
city: Belgrade
country: Serbia
facility: Clinical Hospital Center Dragisa Misovic Dedinje
city: Belgrade
country: Serbia
facility: Local Institution - 4304
city: Belgrade
country: Serbia
facility: Local Institution - 4308
city: Gornja Toponica
country: Serbia
facility: Local Institution - 1-13JAX17Q
city: Gornja Toponica
country: Serbia
facility: Local Institution - 4312
city: Kovin
country: Serbia
facility: Special Hospital for Psychiatric Diseases Kovin
city: Kragujevac
country: Serbia
facility: Local Institution - 4301
city: Kragujevac
country: Serbia
facility: Local Institution - 4303
city: Kragujevac
country: Serbia
facility: Local Institution - 4310
city: Novi Sad
country: Serbia
facility: Local Institution - 4309
city: Vršac
country: Serbia
facility: Local Institution - 4311
city: Kosice
country: Slovakia
facility: Univerzitna nemocnica L Pasteura Kosice-Rastislavova 43
state: Košický Kraj
city: Banská Bystrica
country: Slovakia
facility: Local Institution - 4401
city: Dubnica nad Váhom
country: Slovakia
facility: KONZILIUM s.r.o
city: Košice
country: Slovakia
facility: EPAMED s.r.o
city: Pezinok
country: Slovakia
facility: Local Institution - 1-13JED85D
city: Pezinok
country: Slovakia
facility: Local Institution - 4407
city: Vranov nad Topľou
country: Slovakia
facility: Crystal Comfort, s.r.o.
city: Majadahonda
country: Spain
facility: Local Institution - 2211
state: Madrid
city: Barcelona
country: Spain
facility: Local Institution - 2205
city: Lleida
country: Spain
facility: Local Institution - 2212
city: Madrid
country: Spain
facility: Local Institution - 2207
city: Madrid
country: Spain
facility: Local Institution - 2210
city: Salamanca
country: Spain
facility: Complejo Asistencial Universitario de Salamanca - H. Clinico
city: Sevilla
country: Spain
facility: Local Institution - 2201
city: Valladolid
country: Spain
facility: Hospital Universitario Rio Hortega
city: Zamora
country: Spain
facility: Local Institution - 2202
city: Zaragoza
country: Spain
facility: Hospital Viamed Montecanal
city: Atakum
country: Turkey
facility: Local Institution - 4702
state: Samsun
city: Ankara
country: Turkey
facility: Local Institution - 4706
city: Eskisehir
country: Turkey
facility: Local Institution - 4701
city: Istanbul
country: Turkey
facility: Local Institution - 4704
city: Izmir
country: Turkey
facility: Local Institution - 4705
city: Izmir
country: Turkey
facility: Local Institution - 4703
city: Ilford
country: United Kingdom
facility: Local Institution - 2110
state: Greater London
city: Swinton
country: United Kingdom
facility: Local Institution - 2108
state: Greater Manchester
city: Aberdeen
country: United Kingdom
facility: Local Institution - 2105
city: Chertsey
country: United Kingdom
facility: Local Institution - 2109
city: Leeds
country: United Kingdom
facility: Local Institution - 2106
city: Motherwell
country: United Kingdom
facility: Local Institution - 2104
city: Preston
country: United Kingdom
facility: Local Institution - 2111
city: Sheffield, SouthYorkshire
country: United Kingdom
facility: Local Institution - 2107
city: Swindon
country: United Kingdom
facility: Local Institution - 2103
Study officials:
affiliation: Bristol-Myers Squibb
name: Bristol-Myers Squibb
role: STUDY_DIRECTOR
References: