louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT02983331: Mortality After Endoscopic Retrograde Cholangiopancreatography
Official title: Patients With Mortality After Endoscopic Retrograde Cholangiopancreatography
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Cholangiopancreatography, Endoscopic Retrograde
Mortality
Deep Sedation
Lead sponsor: Umraniye Education and Research Hospital
Sponsor class: OTHER_GOV
First posted: 2016-12-06
Enrollment: 1471
Sex: ALL
Minimum age (years): 42
Maximum age (years): 90
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Time perspective: RETROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: We retrospectively reviewed 1471 patients who underwent elective or emergent ERCP at semi-prone position under pharyngeal anesthesia (lidocaine spray) with routine monitoring (including electrocardiography, non-invasive blood pressure, peripheral capillary oxygen saturation) and standard sedation protocol

Brief summary: In this study, the investigators aimed to overview patients with specific and non-specific complications who admitted to intensive care unit following endoscopic retrograde cholangiopancreatography and had fatal course in the facility

Detailed description: The investigators retrospectively reviewed patients who underwent elective or emergent endoscopic retrograde cholangiopancreatography at semi-prone position under pharyngeal anesthesia (lidocaine spray) with routine monitoring (including electrocardiography, non-invasive blood pressure, peripheral capillary oxygen saturation) and standard sedation protocol (midazolam 0.02 mgkg-1; fentanyl, 1 mgkg-1; propofol 1 mgkg-1) between 2011 and 2016 after approval of local ethics committee of Umraniye Training Hospital.

Eligibility criteria: Inclusion Criteria:

* Patients who underwent elective or emergent ERCP at semi-prone position with routine monitoring and standard sedation protocol

Exclusion Criteria:

* Patients who discharged to ward after treatment and follow-up in ICU

Primary outcomes:
measure: Number of Participants With endoscopic retrograde cholangiopancreatography Related complications
timeFrame: 5 years
measure: Rate of anaesthesia related mortality of the endoscopic retrograde cholangiopancreatographyprocedure under sedation
timeFrame: 5 years
Secondary outcomes:
measure: Value of Acute Physiology and Chronic Health Evaluation (APACHE II) score for predicting mortality
timeFrame: 5 years
measure: Value of Charlson comorbidity index (CCI) score for predicting mortality
timeFrame: 5 years
Other outcomes:
Locations:
city: Istanbul
country: Turkey
facility: Istanbul Umraniye Training Hospital
Study officials:
affiliation: Umraniye Research Hospital
name: Gulsah Karaoren, MD
role: PRINCIPAL_INVESTIGATOR
References:
citation: Katsinelos P, Lazaraki G, Chatzimavroudis G, Gkagkalis S, Vasiliadis I, Papaeuthimiou A, Terzoudis S, Pilpilidis I, Zavos C, Kountouras J. Risk factors for therapeutic ERCP-related complications: an analysis of 2,715 cases performed by a single endoscopist. Ann Gastroenterol. 2014;27(1):65-72.
Clinical trial NCT00348231: Jikei Optimal Insulin Therapy in Type 2 Diabetes
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Diabetes Mellitus, Type 2
Keywords: diabetes mellitus, biphasic insulin analogue
Lead sponsor: Jikei University School of Medicine
Sponsor class: OTHER
Collaborators: name: Novo Nordisk A/S
First posted: 2006-07-04
Enrollment: 60
Sex: ALL
Minimum age (years): 20
Maximum age (years): 80
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The purpose of this study is to compare whether there is the difference in the effect of insulin therapy by the number of times of insulin injection.

Detailed description: The current insulin therapy is divided into the conventional insulin therapy (1\~2 injections per day) and the intensive insulin therapy (3\~4 injections per day). The kinetics of exogenous insulin in the intensive insulin therapy imitate the kinetics of insulin secretion in a healthy person. A previous large clinical study (e.g. DCCT, Kumamoto study, etc.) suggested that intensive insulin therapy prevented microangiopathy and macroangiopathy, and inhibited progression of them, however many patients chose conventional insulin therapy because many hoped that they injected insulin as few as possible. The patients thought that their life styles were disturbed by many times of insulin injection.

The current dual-acting insulin made from insulin as part modified by protamine is able to suppress postprandial hyperglycemia. The new insulin may possibly have the kinetics of insulin in the patient who uses insulin as the intensive insulin therapy. Moreover, the patients will receive the insulin therapy easily if the times of insulin injection are fewer. It may lead to perform the more effective insulin therapy to search for the optimal insulin therapy in induction in type 2 diabetes.

comparison:HbA1c, glycated albumin, IMT, lipid profile,body weight, daily profile of blood glucose,between the conventional insulin therapy and the intensive insulin therapy.

Eligibility criteria: Inclusion Criteria:

* Clinical diagnosis of Type 2 diabetes
* secondary failure of SU drug
* whose age is to 80 from 20 years old

Exclusion Criteria:

* who has the complication
* who has a allergy of insulin
* who is pregnant

Primary outcomes:
measure: HbA1c
measure: daily profile of blood glucose
Secondary outcomes:
measure: IMT
measure: QOL
Other outcomes:
Locations:
city: Tokyo
country: Japan
facility: The Jikei university school of medicine division of diabetes and endoclinology dept. of internal medicine
Study officials:
affiliation: The Jikei University School of Medicine
name: Yumi Miyashita, MD
role: PRINCIPAL_INVESTIGATOR
References:
citation: Miyashita Y, Nishimura R, Nemoto M, Matsudaira T, Kurata H, Yokota T, Yokota K, Tojo K, Utsunomiya K, Tajima N. Prospective randomized study for optimal insulin therapy in type 2 diabetic patients with secondary failure. Cardiovasc Diabetol. 2008 May 29;7:16. doi: 10.1186/1475-2840-7-16.
Clinical trial NCT04577131: Improving Adherence to Home Blood Pressure Monitoring With Pharmacist Support
Official title: Improving Adherence to Home Blood Pressure Monitoring With Pharmacist Support
Study type: INTERVENTIONAL
Overall status: TERMINATED
Phase: NA
Conditions: Hypertension
Lead sponsor: Virginia Commonwealth University
Sponsor class: OTHER
First posted: 2020-10-06
Enrollment: 1
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: SUPPORTIVE_CARE

Brief summary: The purpose of this research study is to evaluate the impact of monitoring blood pressure from home everyday with pharmacist support.

Detailed description: High blood pressure is very common and increases risk of heart, kidney, brain, and eye disease. It is important to diagnose and treat high blood pressure to reduce risk of these complications. Getting blood pressure checked only when someone sees a doctor is not the best way to diagnose high blood pressure or to make sure blood pressure is well managed. Checking blood pressure at home gives a better idea of whether someone's blood pressure is normal or too high.

As part of their usual blood pressure monitoring, participants will be given an Omron 3 series or 5 series blood pressure monitor which has been cleared by the US Food and Drug Administration and validated to meet accuracy and performance requirements. For one month, participants will monitor their blood pressure once a day and then return the device to the clinic at the end of the study. Participants will text their blood pressure result to the American Heart Association's Check, Change, Control (CCC) secure online tracker.

As part of the research study, participants will also be randomized to either receive or not receive weekly check-in phone calls from a pharmacist to review their blood pressures and the number of times they tested in that week. Approximately 50 individuals will participate in this study. Participation in this study will last 1 month.

Eligibility criteria: Inclusion Criteria:

* 18 years of age and older
* Uncontrolled hypertension (BP \> 130/80 mm Hg)

Exclusion Criteria:

* non-English speaking patients
* patients without a mobile phone or texting capability

Primary outcomes:
measure: Change in adherence to home blood pressure monitoring
timeFrame: 1 month
measure: Change in proportion of participants with a blood pressure <130/80 mm Hg.
timeFrame: 1 month
Secondary outcomes:
Other outcomes:
Locations:
city: Richmond
country: United States
facility: Virginia Commonwealth University
state: Virginia
Study officials:
affiliation: Virginia Commonwealth University
name: Dave Dixon, PharmD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT04355273: Effects of Different Concentrations of Pressurized-heparin Flushing Fluid on Coagulation and Platelet Function Monitored by the Sonoclot Analyzer
Official title: Effects of Different Concentrations of Pressurized-heparin Flushing Fluid on Coagulation and Platelet Function Monitored by the Sonoclot Analyzer
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Heparin
Perioperative
Lead sponsor: Yangzhou University
Sponsor class: OTHER
First posted: 2020-04-21
Enrollment: 60
Sex: ALL
Minimum age (years): 18
Maximum age (years): 75
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: PREVENTION

Brief summary: Heparin diluent or normal saline is generally used as the arterial tube flushing in clinical practice, but there is no consensus on the choice of flushing fluid. Heparin can affect the blood coagulation function, and even lead to heparin-related thrombocytopenia, increasing the risk of perioperative embolism. Sonoclot is a blood viscoelasticity test, which can provide comprehensive information on the coagulation's cascade and the entire process and be quicker and more effective than routine laboratory coagulation tests. In this research, the coagulation and platelet function analyzer called Sonoclot is used to evaluate the effect of different concentrations of pressurized heparin on the coagulation and platelet function of perioperative patients, which can provide a reference for the clinical choice of appropriate arterial flushing.


Eligibility criteria: Inclusion Criteria:

* Diagnosis of gastrointestinal cancer
* Ages ranged from 18 to 75
* ASA I\~III

Exclusion Criteria:

* Pregnancy
* modified Allen Test negative
* history of taking anti-platelet drugs such as aspirin one week before surgery, heparin allergy and thrombotherapy
* two failed catheterizations of the same artery
* significant diseases in liver and kidney function
* refusal of patients

Primary outcomes:
measure: The level of glass bead Activated Clotting Time
timeFrame: through study completion, an average of 3 minute
Secondary outcomes:
measure: The level of glass bead Clot Rate
timeFrame: through study completion, an average of 3 minute
measure: The level of glass bead Platelet Function
timeFrame: through study completion, an average of 3 minute
measure: The level of platelet count
timeFrame: through study completion, an average of 2 minute
measure: The frequencies of hand positional changes and manual artery flushing
timeFrame: intraoperative
measure: The amount of infusion volume, blood loss, urine volume
timeFrame: intraoperative
measure: The appearance of local complications of arterial puncture
timeFrame: within 24 h after surgery
Other outcomes:
Locations:
city: Yangzhou
country: China
facility: the Affiliated Hospital of Yangzhou University, Yangzhou University
state: Jiangsu
Study officials:
References:
Clinical trial NCT07009873: Clinical Application of Wearable Ultrasound Sensors
Official title: Clinical Application on the R&D Purpose of Wearable Ultrasound Sensors:A Single-Center Prospective Study
Study type: OBSERVATIONAL
Overall status: NOT_YET_RECRUITING
Conditions: DVT - Deep Vein Thrombosis
POCUS
Lead sponsor: Chinese PLA General Hospital
Sponsor class: OTHER
First posted: 2025-06-08
Enrollment: 300
Sex: ALL
Minimum age (years): 18
Maximum age (years): 70
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: OTHER
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Participant recruitment will be conducted by licensed physicians during routine clinical follow-up.

Brief summary: This study aims to develop and evaluate a wearable ultrasound imaging sensor for the early diagnosis and real-time monitoring of various diseases, such as cardiovascular conditions and structural abnormalities of superficial organs. With advancements in medical technology, wearable devices have attracted increasing attention for their portability and real-time capabilities.


Eligibility criteria: Inclusion Criteria:

* Age ≥ 18 yrs and able to consent
* Relevant diagnosis for study arm (heart failure, lower-limb DVT, or ICU monitoring)
* Adequate acoustic window and intact skin at sensor site

Arm-specific:

* Heart-failure arm: Clinically stable HFrEF or HFpEF on standard therapy
* DVT arm: Imaging-confirmed lower-limb DVT, anticoagulated or scheduled for intervention
* ICU arm: ICU/post-op patient requiring continuous bedside ultrasound

Exclusion Criteria:

* Poor acoustic window preventing interpretable images
* Local skin infection, open wound, or implant/hardware blocking sensor
* Inability to cooperate with monitoring

Arm-specific:

* Heart-failure arm: Acute MI or uncontrolled arrhythmia in past 3 months
* DVT arm: Active bleeding or severe coagulopathy
* ICU arm: Unstable multi-organ failure precluding safe monitoring

Primary outcomes:
measure: Image Quality
timeFrame: Day 1 (Baseline): Measured immediately after first wearable sensor placement
measure: Image Quality
timeFrame: Day 1 (Baseline): Measured immediately after first wearable sensor placement
Secondary outcomes:
measure: Consistency of image quality
timeFrame: Day 1 (Baseline): Measured immediately after first wearable sensor placement
measure: Consistency of image quality
timeFrame: Day 1 (Baseline): Measured during the initial imaging session
measure: Consistency of image quality
timeFrame: Day 1 (Baseline): Measured during the initial imaging session
Other outcomes:
Locations:
city: Beijing
country: China
facility: Chinese PLA General Hospital
state: Beijing
Study officials:
affiliation: Chinese PLA General Hospital
name: Yukun Luo, Professor, M.D.
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT03589573: Effect of Muscle Strength on Hamstring Flexibility in Children With Duchenne Muscular Dystrophy
Official title: Effect of Trunk and Lower Extremity Muscle Strength on Hamstring Flexibility in Children With Duchenne Muscular Dystrophy
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Duchenne Muscular Dystrophy
Muscle Strength
Lower Extremity
Hamstring Contractures
Keywords: Duchenne Muscular Dystrophy
muscle strength
hamstring flexibility
back muscle
lower extremity
Lead sponsor: Hacettepe University
Sponsor class: OTHER
First posted: 2018-07-18
Enrollment: 30
Sex: MALE
Minimum age (years): 5
Maximum age (years): 18
Standard ages: CHILD
ADULT
Accepts healthy volunteers: no
Observational model: OTHER
Time perspective: OTHER
Sampling method: PROBABILITY_SAMPLE
Study population: Thirty children whose functional levels were in 1 or 2 according to the Brooke Lower Extremity Functional Classification Scale were included in the study. Flexibilities of hamstrings was evaluated by Popliteal Angle Test. Muscle strenght was assessed with manuel muscle strength test and myometer. correlation between the flexibility of hamstrings and muscle strength tests were examined.

Brief summary: Investigator researched that the effect of trunk and lower extremity muscle strength on hamstring flexibility in children with Duchenne Muscular Dystrophy.

Detailed description: Thirty children were asessed by physical therapist. Nineteen children was Level 1 and eleven children was Level 2 according to Brooke Lower Extremity Functional Classification Scale.

Eligibility criteria: Inclusion Criteria:

* Getting a Duchenne Muscular Dystrophy diagnosis,
* Being in ambulatuar phases and independently climbing four stairs
* To be cooperate to physioterapist's directions

Exclusion Criteria:

* Having severe contracture in the lower extremity
* Having undergone surgery in the past 6 months

Primary outcomes:
measure: popliteal angle test
timeFrame: 5 minute
Secondary outcomes:
measure: trunk and lower extremity muscle strength test
timeFrame: 20 minute
Other outcomes:
Locations:
city: Ankara
country: Turkey
facility: Hacettepe University
state: Sıhhiye
Study officials:
affiliation: Hacettepe University
name: Lütfiye Akkurt, Msc.
role: PRINCIPAL_INVESTIGATOR
affiliation: Hacettepe University
name: Öznur Yılmaz, Prof.
role: STUDY_DIRECTOR
affiliation: Hacettepe University
name: İpek Gürbüz, Assoc.Prof.
role: PRINCIPAL_INVESTIGATOR
affiliation: Hacettepe University
name: Ayşe Karaduman, Prof.
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT02903173: An Observational Study of Post-cesarean Delivery Respiratory Patterns Using a Non-invasive Minute Ventilation Monitor (Exspiron ™ System)
Official title: An Observational Study of Post-cesarean Delivery Respiratory Patterns Using a Non-invasive Minute Ventilation Monitor (Exspiron ™ System)
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Pregnancy
Analgesia
Respiratory Depression
Obstructive Sleep Apnea
Postpartum
Keywords: respiratory depression
postpartum
neuraxial morphine
cesarean delivery
Lead sponsor: Duke University
Sponsor class: OTHER
Collaborators: name: Respiratory Motion, Inc.
First posted: 2016-09-16
Enrollment: 54
Sex: FEMALE
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: Subjects will be pregnant woman recruited from the Duke Birthing Center (DBC) in the 5700 unit of Duke Hospital who are scheduled for planned cesarean delivery.

Brief summary: The purpose of this study is to evaluate the breathing patterns of women who undergo cesarean delivery with spinal or epidural morphine for post-operative pain control in the first day after surgery. Some women who undergo cesarean delivery may be at risk for respiratory complications related to opiate administration for post-operative pain. The primary aim of this study is to evaluate post-operative minute ventilation in women who undergo cesarean delivery using a novel method of non-invasive minute ventilation monitoring, and to see if there are predictive risk factors that may predispose women to post-operative hypoventilation.


Eligibility criteria: Inclusion Criteria:

* 18 years or older
* planned cesarean delivery with neuraxial morphine for post-operative analgesia

Exclusion Criteria:

* Non-English speaking subjects
* patients who undergo urgent or emergent cesarean deliveries
* patients who receive general anesthesia or do not receive neuraxial morphine

Primary outcomes:
measure: Change in minute ventilation
timeFrame: baseline and 24 hours post cesarian delivery
Secondary outcomes:
measure: Berlin Questionnaire
timeFrame: Baseline
measure: STOP-BANG Questionnaire
timeFrame: Baseline
measure: Epworth Sleepiness Scale
timeFrame: Baseline
Other outcomes:
Locations:
city: Durham
country: United States
facility: Duke University Medical Center
state: North Carolina
Study officials:
affiliation: Duke University
name: Jennifer Dominguez
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT06378073: Effects of Chest Physiotherapy Exercise in Prevention of Pre and Post Operative Complications By Cardiac Surgery
Official title: Effects of Chest Physiotherapy Exercise in Prevention of Pre-Operative and Post-Operative Complications Followed By Cardiac Surgery
Study type: INTERVENTIONAL
Overall status: ACTIVE_NOT_RECRUITING
Phase: NA
Conditions: Surgery-Complications
Lead sponsor: Superior University
Sponsor class: OTHER
First posted: 2024-04-22
Enrollment: 189
Sex: ALL
Minimum age (years): 48
Maximum age (years): 88
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: DIAGNOSTIC

Brief summary: "A randomized control trial will be conducted among 189 patients who have undergone cardiac surgery in past. The participants for this research will be patients of Pakistan Institute of Cardiology, University of Lahore Teaching Hospital, Azra Naheed Medical College and Bahria International Hospital. The chest physiotherapy technique will be applied on 2 controlled groups.

In 94 patients the effects of chest physiotherapy will be checked post - operatively and the effects will be checked on other half pre - operatively. The data will be gathered on practical performance and treatment based along with questionnaire. The data collected will then be analyzed using SPSS"


Eligibility criteria: Inclusion Criteria:

* Patients undergoing in Cardiac Surgery like, CABG, univalve, bivalve and trivalve.

Exclusion Criteria:

* Valve and CABG surgery combined with other cardiac surgery like percutaneous valve replacement.
* Cognitive disorder of the heart.

Primary outcomes:
measure: Incentive Spirometer
timeFrame: 6 Month
measure: Incentive Spirometer
timeFrame: 6 Months
Secondary outcomes:
Other outcomes:
Locations:
city: Lahore
country: Pakistan
facility: Azra Naheed Medical College, Superior University
state: Punjab
city: Lahore
country: Pakistan
facility: Bahria Hospital
state: Punjab
city: Lahore
country: Pakistan
facility: Chaudary Muhammad Akram Teaching Hospital, Azra Naheed Medical College, Superior University
state: Punjab
city: Lahore
country: Pakistan
facility: The University of Lahore Teaching Hospital
state: Punjab
city: Lahore
country: Pakistan
facility: Punjab Institute of Cardiology Hospital
Study officials:
References: