louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT02806115: The Efficacy of Severe Whitening and Delayed Fading in Acetic Acid-enhanced Endoscopy for Diagnosing Gastric Intestinal Metaplasia
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: PHASE1
Conditions: Gastric Intestinal Metaplasia
Lead sponsor: Shandong University
Sponsor class: OTHER
First posted: 2016-06-20
Enrollment: 100
Sex: ALL
Minimum age (years): 18
Maximum age (years): 80
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: DIAGNOSTIC

Brief summary: Investigators found that the degree and the duration of aceto-whitening differed between gastric intestinal metaplasia(GIM) and the surrounding normal mucosa: the area of GIM showed a severe degree of aceto whiteness and the whitening continued longer than the surrounding normal mucosa, which investigators called "severe whitening" and "delayed fading", and investigators realized that GIM could possibly be diagnosed by using these differences.The aim of this prospective study was to investigate the efficacy of "severe whitening" and "delayed fading" for diagnosing GIM.


Eligibility criteria: Inclusion Criteria:

* long-lasting upper gastrointestinal symptoms (\>15 years)
* atrophic gastritis or GIM identified at surveillance endoscopy

Exclusion Criteria:

* presence of advanced adenocarcinoma in the stomach
* presence of acute gastrointestinal bleeding
* presence of coagulopathy, uncontrolled impaired renal or liver disease
* presence of pregnancy or lactation
* presence of allergy to acetic acid
* age younger than 18 years or older than 80 years
* inability to provide written informed consent.

Primary outcomes:
measure: accuracy of "severe whitening" for diagnosing gastric intestinal metaplasia
timeFrame: 6 months
measure: accuracy of "delayed fading" for diagnosing gastric intestinal metaplasia
timeFrame: 6 months
Secondary outcomes:
Other outcomes:
Locations:
city: Jinan
country: China
facility: Qilu Hospital, Shandong University
state: Shandong
Study officials:
affiliation: Qilu Hospital of Shandong University
name: Xiuli Zuo, PhD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT03541915: Magnesium Sulfate; Postoperative Nausea and Vomiting; Laparoscopic Surgery
Official title: The Effect of Intravenous Magnesium Sulfate on Postoperative Nausea and Vomiting in Patients Undergoing Laparoscopic Gynecologic Surgery
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Gynecologic Disease
Lead sponsor: Gangnam Severance Hospital
Sponsor class: OTHER
First posted: 2018-05-31
Enrollment: 90
Sex: FEMALE
Minimum age (years): 20
Maximum age (years): 65
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: PREVENTION

Brief summary: Postoperative nausea and vomiting (PONV) is commonly accompanied in patients undergoing surgery under general anesthesia. The patients undergoing laparoscopic gynecologic surgery have multiple risk factors for developing PONV such as female gender, nonsmoker, postoperative opioids, and laparoscopic surgery. Thus, it is important to prevent PONV in these patients.

Detailed description: Magnesium is a N-methyl-D-aspartate (NMDA) antagonist that is known to be effective in reducing opioid consumption and controlling postoperative pain. This opioid reducing effect can be associated with reduction of the incidence of PONV. However, the effect of magnesium on preventing PONV have not been investigated before. Thus, the investigators hypothesized that intraoperative infusion of magnesium will be effective in preventing PONV in patients undergoing laparoscopic gynecologic surgery.

Eligibility criteria: Inclusion Criteria:

* Gynecologic disease
* Female patients undergoing laparoscopic gynecologic surgery and receiving postoperative fentanyl based intravenous patient controlled analgesia (PCA), aged 20-65 years.

Exclusion Criteria:

* impaired renal or hepatic function (Glutamic Oxalacetate Transaminase \[GOT\]/Glutamic Pyruvate Transaminase \[GPT\]\>50, estimated glomerular filtration rate \[eGFR\]\<60)
* atrioventricular block, myopathies, diabetes, treated with calcium channel blockers
* History of receiving antiemetics within 1 day before surgery
* History of receiving opioids or non-steroidal anti-inflammatory drugs within 1 week of surgery
* drugs or alcohol abuse
* patients treated with isoniazid, chlorpromazine, or digoxin
* patients who cannot communicated with others or with cognitive dysfunction
* patients who cannot read informed consent

Primary outcomes:
measure: The incidence of PONV
timeFrame: up to postoperative 2 days
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
References:
Clinical trial NCT05183815: Effectiveness of Slow Back Stroke Massage and Murrotal Quran on Fatigue and Quality of Life of Patients Undergoing Haemodialysis
Official title: Effectiveness of Slow Back Stroke Massage and Murrotal Quran on Fatigue and
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Fatigue; Hemodialysis; Chronic Kidney Disease; Quality of Life
Lead sponsor: Universitas Muhammadiyah Yogyakarta
Sponsor class: OTHER
First posted: 2022-01-11
Enrollment: 30
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: SUPPORTIVE_CARE

Brief summary: The study aimed to investigate the effectiveness of slow back stroke massage and murrotal Quran on fatigue and quality of life on patients undergoing hemodialysis.


Eligibility criteria: Inclusion Criteria:

* patients undergoing hemodialysis minimal 6 months

Exclusion Criteria:

* patients with hear impairment

Primary outcomes:
measure: Level of Fatigue
timeFrame: 4 weeks
measure: Level of quality of life
timeFrame: 4 weeks
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
References:
Clinical trial NCT06836115: Reading and Stuttering
Official title: Reading Problems and Stuttering
Study type: OBSERVATIONAL
Overall status: NOT_YET_RECRUITING
Conditions: Dyslexia
Lead sponsor: Minia University
Sponsor class: OTHER
First posted: 2025-02-20
Enrollment: 200
Sex: ALL
Minimum age (years): 9
Maximum age (years): 10
Standard ages: CHILD
Accepts healthy volunteers: yes
Observational model: CASE_CONTROL
Time perspective: RETROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: This study will include 200 patients. Subjects will be divided into two groups, group A will include with 100 participants with developmental stuttering and group B will include 100 participants with normal fluency speech.

Brief summary: Dyslexia is a common neurodevelopmental condition, which manifests itself in the form of reading difficulties and occurs in 7-10% of the population (Peterson \& Pennington, 2012).

As for dyslexia, it is one of the most common learning disorders and the most common cause of difficulties with reading, writing, and spelling. The global prevalence of dyslexia is estimated to be between 5% and 10% of the population, but it may be as high as 17% (Sprenger-Charolles et al., 2011). Stuttering is a speech disorder characterized by involuntary, audible, or silent repetitions or prolongations of sounds or syllables, along with disturbances in the fluency of verbal phrases.Stuttering and dyslexia are two processing deficits that have an impact on a person's social and academic lives, especially as they usually affect the pediatric population more than adults. Even though they affect different domains, they have similar characteristics in their pathogenesis, epidemiology, and impact on life (Algaidy et al., 2023). The aim of the study will be to identify the prevelance of dyslexia in developmental stuttering.


Eligibility criteria: Inclusion Criteria:

* children with stuttering

Exclusion Criteria:

* children with delayed language development

Primary outcomes:
measure: 4- Arabic Reading Test
timeFrame: baseline
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
References:
Clinical trial NCT05143515: The Effectiveness of PACE Label on Reducing Food Consumption and Increasing Physical Activity Levels
Official title: The Effectiveness of Physical Activity Calorie Equivalent (PACE) Label on Reducing Food Consumption and Increasing Physical Activity Levels: a Randomized Controlled Trial
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Health Behavior
Lead sponsor: Loughborough University
Sponsor class: OTHER
First posted: 2021-12-03
Enrollment: 103
Sex: ALL
Minimum age (years): 18
Maximum age (years): 75
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: PREVENTION

Brief summary: Background: More people are at the risk of chronic disease as the prevalence of obesity increases. It is therefore essential to find ways of helping consumers to make a lower calorie food choice. Current evidence indicates that current food labelling is changing food choices and consumption, but it is of limited effectiveness. Purpose: The purpose of this study is to assess the efficacy of physical activity calorie equivalent (PACE) food labelling on food selection and consumption using a randomised experimental design in pop-up café. Method: This study as a randomised controlled experimental trial (RCT) was conducted in a research kitchen at Loughborough University. Participants were blinded to the exact purpose of the study and randomised to either exposure to PACE labelling plus calorie food labelling or calorie labelling only and asked to select food/drinks for their consumption, in the pop-up café up to a maximum value cost of £10. The study outcomes were the amount of money spent, the number of calories selected, and the amount of food consumed after exposure to the two different types of food labels.


Eligibility criteria: Inclusion Criteria:

* at least 18 years old
* healthy

Exclusion Criteria:

* allergic to the foods in the pop up café
* chronic disease such as insulin-dependent diabetes
* BMI lower than 16 kg/m2.

Primary outcomes:
measure: Money Spent
timeFrame: Immediately after the intervention
measure: Calorie Intake
timeFrame: Immediately after the intervention
measure: The International Physical Activity Questionnaires(IPAQ)
timeFrame: 24 hours after the intervention
Secondary outcomes:
Other outcomes:
Locations:
city: Loughborough
country: United Kingdom
facility: Loughborough University
state: Leicester
Study officials:
References:
Clinical trial NCT05631015: Artificial Intelligence for Determination of Gastroscopy Surveillance Intervals
Official title: Development and Validation of Gastroscopy Surveillance Recommendations Based on Natural Language Processing for Patients With Gastric Cancer and Precancerous Diseases
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Helicobacter Pylori Infection
Atrophic Gastritis
Intestinal Metaplasia
Low Grade Intraepithelial Neoplasia
High Grade Intraepithelial Neoplasia
Early Gastric Cancer
Gastric Cancer
Lead sponsor: Shandong University
Sponsor class: OTHER
First posted: 2022-11-30
Enrollment: 2000
Sex: ALL
Minimum age (years): 18
Maximum age (years): 80
Standard ages: ADULT
OLDER_ADULT
Observational model: OTHER
Time perspective: RETROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: patients who came to Qilu Hospital of Shandong University and received endoscopy examination but not therapeutic endoscopy

Brief summary: The purpose of this study is to develop and validate a clinical decision support system based on automated algorithms. This system can use natural language processing to extract data from patients' endoscopic reports and pathological reports, identify patients' disease types and grades, and generate guidelines based follow-up or treatment recommendations


Eligibility criteria: Inclusion Criteria:

* Patients aged 18 - 80 years
* Patients underwent endoscopic examination

Exclusion Criteria:

* Patients with the contraindications to endoscopic examination
* Patients with imcomplete examination information
* Patients undergo endoscopy for therapy
* Patients have history of upper gastrointestinal surgery
* Patients with duodenal or Laryngeal neoplasms
* Patients with gastrointestinal submucosal tumor

Primary outcomes:
measure: The diagnostic accuracy of gastric diseases with deep learning algorithm
timeFrame: 12 month
measure: The accuracy of recommentions for different disease with deep learning algorithm
timeFrame: 12 month
Secondary outcomes:
measure: The diagnostic sensitivity of gastric diseases with deep learning algorithm
timeFrame: 12 month
measure: The diagnostic specificity of gastric diseases with deep learning algorithm
timeFrame: 12 month
measure: The diagnostic positive predictive value of gastric diseases with deep learning algorithm
timeFrame: 12 month
measure: The diagnostic negative predictive value of gastric diseases with deep learning algorithm
timeFrame: 12 month
measure: The F-score of gastric diseases with deep learning algorithm
timeFrame: 12 month
Other outcomes:
Locations:
city: Jinan
country: China
facility: Qilu Hospital, Shandong University
state: Shandong
Study officials:
References:
Clinical trial NCT01147315: ORN Study: Curative Treatment of Osteoradionecrosis (ORN) With Hybrid Bone Substitution
Official title: 10 Patients Bicentric Prospective Study of Hybrid Bone Substitution With Calcium-phosphate Ceramic Biomaterial and Autologous Bone Marrow for Mandibular Osteoradionecrosis (ORN) Treatment
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Mandible
Osteoradionecrosis
Keywords: mandibular osteoradionecrosis
hybrid bone substitution
calcium-phosphate ceramic biomaterial
autologous bone marrow
Lead sponsor: Nantes University Hospital
Sponsor class: OTHER
First posted: 2010-06-22
Enrollment: 13
Sex: ALL
Minimum age (years): 18
Maximum age (years): 75
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: TREATMENT

Brief summary: The main objective of the study is the cure of osteoradionecrosis (ORN) at 12 months.


Eligibility criteria: Inclusion Criteria:

* Adult patients (between 18 and 75 years) affiliated with an appropriate social security system, diagnosed as suffering from symptomatic ORN, radiologically confirmed, for which surgery is indicated
* Presence maximum of 2 outbreaks of ORN
* Oncological remission of the original tumor site for 1 year and for 3 years if the ORN is in the contact or close to the initial tumoral site
* ECOG performance status 0, 1 or 2
* ORN symptomatic accessible to the conservation of at least one cortical mandibular basilar
* Signed informed consent

Exclusion Criteria:

* Oncological treatment
* Haematologic background
* Current bone necrosis consecutive or concurrent to taking bisphosphonates
* Extension of ORN does not allow the retention of a mandibular rod (bicortical form)
* Presence of fracture complicating ORN
* Bisphosphonates during the last year
* Contraindications to the removal of iliac or sternum bone marrow
* Contraindication for general anesthesia

Primary outcomes:
measure: The cure of ORN
timeFrame: 12 months
Secondary outcomes:
measure: Evaluation of post operative pain at mandibular and bone marrow sampling site
measure: Quality of life
measure: Possibility of secondary dental prosthetic devices
measure: CT semiology description of the treated area
measure: Bone regeneration
measure: Number of hospital days
measure: Safety of hybrid bone substitution
Other outcomes:
Locations:
city: Nantes
country: France
facility: Nantes University Hospital
city: Rennes
country: France
facility: Rennes University Hospital
Study officials:
affiliation: Nantes University Hospital
name: Olivier Malard, Pr
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT06778915: Surgical Strategy for Head and Neck Adenoid Cystic Cancer
Official title: Refining Surgical Strategies Based on Tumor Staging in Head and Neck Adenoid Cystic Carcinoma: Evidence from a Retrospective Cohort Study
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Adenoid Cystic Carcinoma
Lead sponsor: Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University
Sponsor class: OTHER
First posted: 2025-01-16
Enrollment: 309
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: RETROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: head and neck adenoid cystic carcinoma

Brief summary: To investigate the relationship between surgical margins and outcomes across different tumor stages, in order to provide evidence and guidance for refining stage-specific surgical approaches.

Detailed description: Adenoid cystic carcinoma of the head and neck (HNACC) presents unique surgical challenges due to its propensity for perineural spread and proximity to critical craniofacial structures. While surgical resection remains the cornerstone of treatment, determining the optimal extent of resection to balance oncologic control and functional preservation requires further investigation. The investigator aimed to investigate the relationship between surgical margins and outcomes across different tumor stages, in order to provide evidence and guidance for refining stage-specific surgical approaches.

Eligibility criteria: Inclusion Criteria:

* patients who underwent surgical resection with curative intent and PORT.

Exclusion Criteria:

* underwent only biopsy, presented with distant metastases or second primary malignancies at initial diagnosis, had incomplete clinical or histopathologic data, or had histologic evidence of high-grade transformation.

Primary outcomes:
measure: Local control
timeFrame: 5 year
Secondary outcomes:
measure: Locoregional Recurrence-Free Survival (LRRFS)
timeFrame: 5 year
measure: Overall Survival (OS)
timeFrame: 5 year
measure: Distant Metastasis-Free Survival (DMFS)
timeFrame: 5 year
Other outcomes:
Locations:
Study officials:
References:
Clinical trial NCT02065115: Study of Ice Application to Reduce Pain From Arterial Punctures
Official title: Cryoanalgesia (Ice Pack) to Reduce the Pain Associated With Arterial Blood Gas Puncture
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Vessel Puncture Site Pain
Keywords: ice
cryotherapy
puncture
pain
Lead sponsor: St. Joseph Hospital, New Hampshire
Sponsor class: OTHER
First posted: 2014-02-17
Enrollment: 82
Sex: ALL
Minimum age (years): 18
Maximum age (years): 100
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: SUPPORTIVE_CARE

Brief summary: This study seeks to determine if cryoanalgesia in the form of ice application could be an effective analgesic when applied before arterial puncture.


Eligibility criteria: Inclusion Criteria:

* subjects ≥ 18 years old referred to the pulmonary function laboratory with a physician order for an arterial blood gas test were sought to complete the study

Exclusion Criteria:

* cold, bluish hands and fingers
* diagnosis of Raynaud's syndrome or scleroderma/CREST syndrome
* history or signs of dementia, confusion, or cognitive impairment
* blindness
* patients not fluent in the English language
* non-palpable radial pulse in the wrist (necessitating brachial puncture)

Primary outcomes:
measure: pain related to arterial puncture
timeFrame: 1-5 minutes after arterial puncture
Secondary outcomes:
Other outcomes:
Locations:
city: Nashua
country: United States
facility: St. Joseph Hospital
state: New Hampshire
Study officials:
affiliation: St. Joseph Hospital, Nashua New Hampshire
name: Jeffrey m Haynes, RRT RPFT
role: PRINCIPAL_INVESTIGATOR
References:
citation: Giner J, Casan P, Belda J, Gonzalez M, Miralda RM, Sanchis J. Pain during arterial puncture. Chest. 1996 Dec;110(6):1443-5. doi: 10.1378/chest.110.6.1443.
citation: Haynes JM. Randomized controlled trial of cryoanalgesia (ice bag) to reduce pain associated with arterial puncture. Respir Care. 2015 Jan;60(1):1-5. doi: 10.4187/respcare.03312. Epub 2014 Dec 16.
Clinical trial NCT00204815: Bone Mineral Density in Pediatric Epilepsy
Official title: Bone Mineral Density in Pediatric Epilepsy: AED-Specific and Duration of Treatment-Specific Effects
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Epilepsy
Lead sponsor: University of Wisconsin, Madison
Sponsor class: OTHER
Collaborators: name: GlaxoSmithKline
First posted: 2005-09-20
Enrollment: 98
Sex: ALL
Minimum age (years): 8
Maximum age (years): 18
Standard ages: CHILD
ADULT
Accepts healthy volunteers: no
Observational model: CASE_ONLY
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Pediatric subjects with generalized or partial seizures

Brief summary: What are the effects of the currently used AEDs on bone mineralization in children and adolescents between the ages of 8 to 18? This is a pilot observational study using DEXA scans to measure bone mineral density in 100 patients The primary objective is to collect preliminary data on bone mineral density, body weight, dietary calcium intake, and activity level.


Eligibility criteria: Inclusion Criteria:

* diagnosis of generalized or partial seizures with or without generalization or a diagnosis of generalized seizures as defined in the International League Against Epilepsy

Exclusion Criteria:

* steroid use
* chronic disease other than epilepsy

Primary outcomes:
Secondary outcomes:
Other outcomes:
Locations:
city: Madison
country: United States
facility: University of Wisconsin Hospital and Clinics
state: Wisconsin
Study officials:
affiliation: University of Wisconsin, Madison
name: Raj Sheth, MD
role: PRINCIPAL_INVESTIGATOR
References: