Clinical trial NCT03335696: Predicting MRI Abnormalities With Longitudinal Data of the Whitehall II Substudy
Official title: Predicting MRI Abnormalities With Longitudinal Data of the Whitehall II Substudy
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Cognitive Impairment
Dementia
Affective Disorders
Keywords: Epidemiology
Magnetic resonance imaging
Diffusion tensor imaging
White matter
Functional MRI
Connectome
Resting state brain networks
Neuropsychology
Lead sponsor: University of Oxford
Sponsor class: OTHER
Collaborators: name: University College, London
First posted: 2017-11-08
Enrollment: 800
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: Randomly selected from phase 11 of the an occupational cohort recruited from 1985 for the Whitehall II study (Marmot M, Brunner E. Cohort Profile: the Whitehall II study. Int J Epidemiol 2005;34(2):251-6).

Brief summary: Follow-up study within the Whitehall II study, selecting 800 participants for further neuropsychological, clinical and imaging (MRI) examinations to examine brain structure and function in relation to age-related diseases and the modifiable and non-modifiable factors affecting resilience against and vulnerability to adverse brain changes.

Detailed description: A total of 6035 civil servants participated in the WHII Phase 11 clinical examination in 2012-2013. A random sample of 800 of these participants was included in a sub-study comprising an MRI brain scan, a detailed clinical and cognitive assessment, and collection of blood and buccal mucosal samples for the characterisation of immune function and associated measures. Data collection for this sub-study started in 2012 and was completed by in 2016. The participants, for whom social and health records have been collected since 1985, were between 60-85 years of age at the time the MRI study started. The pre-specified clinical and cognitive assessment protocols, the state-of-the-art MRI sequences and latest pipelines for analyses of this sub-study have been published and are attached to this application.

Eligibility criteria: Inclusion Criteria:

* Member of Whitehall II cohort attending at UCL for phase 11

Exclusion Criteria:

* Not suitable for MRI, travelling to Oxford, seriously physically ill

Primary outcomes:
measure: Neuropsychological measure 1
timeFrame: 2012-2016
measure: Neuropsychological measure 2
timeFrame: 2012-2016
measure: Neuropsychological measure 3
timeFrame: 2012-2016
measure: Neuropsychological measure 4
timeFrame: 2012-2016
measure: Neuropsychological measure 5
timeFrame: 2012-2016
measure: Neuropsychological measure 6
timeFrame: 2012-2016
measure: Neuropsychological measure 7
timeFrame: 2012-2016
measure: Neuropsychological measure 8
timeFrame: 2012-2016
measure: Neuropsychological measure 9
timeFrame: 2012-2016
measure: MRI Measures 1
timeFrame: 2012-2016
measure: MRI Measures 2
timeFrame: 2012-2016
measure: MRI Measures 3
timeFrame: 2012-2016
measure: MRI Measures 4
timeFrame: 2012-2016
measure: MRI Measures 5
timeFrame: 2012-2016
Secondary outcomes:
Other outcomes:
Locations:
city: Oxford
country: United Kingdom
facility: University of Oxford
state: England
Study officials:
affiliation: University of Oxford
name: Klaus P Ebmeier, MD
role: PRINCIPAL_INVESTIGATOR
References:
citation: Filippini N, Zsoldos E, Haapakoski R, Sexton CE, Mahmood A, Allan CL, Topiwala A, Valkanova V, Brunner EJ, Shipley MJ, Auerbach E, Moeller S, Ugurbil K, Xu J, Yacoub E, Andersson J, Bijsterbosch J, Clare S, Griffanti L, Hess AT, Jenkinson M, Miller KL, Salimi-Khorshidi G, Sotiropoulos SN, Voets NL, Smith SM, Geddes JR, Singh-Manoux A, Mackay CE, Kivimaki M, Ebmeier KP. Study protocol: The Whitehall II imaging sub-study. BMC Psychiatry. 2014 May 30;14:159. doi: 10.1186/1471-244X-14-159.
citation: Allan CL, Zsoldos E, Filippini N, Sexton CE, Topiwala A, Valkanova V, Singh-Manoux A, Tabak AG, Shipley MJ, Mackay C, Ebmeier KP, Kivimaki M. Lifetime hypertension as a predictor of brain structure in older adults: cohort study with a 28-year follow-up. Br J Psychiatry. 2015 Apr;206(4):308-15. doi: 10.1192/bjp.bp.114.153536. Epub 2014 Dec 11.
citation: Topiwala A, Allan CL, Valkanova V, Zsoldos E, Filippini N, Sexton CE, Mahmood A, Singh-Manoux A, Mackay CE, Kivimaki M, Ebmeier KP. Resilience and MRI correlates of cognitive impairment in community-dwelling elders. Br J Psychiatry. 2015 Nov;207(5):435-9. doi: 10.1192/bjp.bp.114.152363. Epub 2015 Sep 3.
citation: Allan CL, Sexton CE, Filippini N, Topiwala A, Mahmood A, Zsoldos E, Singh-Manoux A, Shipley MJ, Kivimaki M, Mackay CE, Ebmeier KP. Sub-threshold depressive symptoms and brain structure: A magnetic resonance imaging study within the Whitehall II cohort. J Affect Disord. 2016 Nov 1;204:219-25. doi: 10.1016/j.jad.2016.06.049. Epub 2016 Jun 21.
citation: Griffanti L, Jenkinson M, Suri S, Zsoldos E, Mahmood A, Filippini N, Sexton CE, Topiwala A, Allan C, Kivimaki M, Singh-Manoux A, Ebmeier KP, Mackay CE, Zamboni G. Classification and characterization of periventricular and deep white matter hyperintensities on MRI: A study in older adults. Neuroimage. 2018 Apr 15;170:174-181. doi: 10.1016/j.neuroimage.2017.03.024. Epub 2017 Mar 15.
citation: Suri S, Emir U, Stagg CJ, Near J, Mekle R, Schubert F, Zsoldos E, Mahmood A, Singh-Manoux A, Kivimaki M, Ebmeier KP, Mackay CE, Filippini N. Effect of age and the APOE gene on metabolite concentrations in the posterior cingulate cortex. Neuroimage. 2017 May 15;152:509-516. doi: 10.1016/j.neuroimage.2017.03.031. Epub 2017 Mar 18.
citation: Topiwala A, Allan CL, Valkanova V, Zsoldos E, Filippini N, Sexton C, Mahmood A, Fooks P, Singh-Manoux A, Mackay CE, Kivimaki M, Ebmeier KP. Moderate alcohol consumption as risk factor for adverse brain outcomes and cognitive decline: longitudinal cohort study. BMJ. 2017 Jun 6;357:j2353. doi: 10.1136/bmj.j2353.
citation: Sexton CE, Zsoldos E, Filippini N, Griffanti L, Winkler A, Mahmood A, Allan CL, Topiwala A, Kyle SD, Spiegelhalder K, Singh-Manoux A, Kivimaki M, Mackay CE, Johansen-Berg H, Ebmeier KP. Associations between self-reported sleep quality and white matter in community-dwelling older adults: A prospective cohort study. Hum Brain Mapp. 2017 Nov;38(11):5465-5473. doi: 10.1002/hbm.23739. Epub 2017 Jul 26.
citation: Suri S, Topiwala A, Filippini N, Zsoldos E, Mahmood A, Sexton CE, Singh-Manoux A, Kivimaki M, Mackay CE, Smith S, Ebmeier KP. Distinct resting-state functional connections associated with episodic and visuospatial memory in older adults. Neuroimage. 2017 Oct 1;159:122-130. doi: 10.1016/j.neuroimage.2017.07.049. Epub 2017 Jul 26.
citation: Heise V, Zsoldos E, Suri S, Sexton C, Topiwala A, Filippini N, Mahmood A, Allan CL, Singh-Manoux A, Kivimaki M, Mackay CE, Ebmeier KP. Uncoupling protein 2 haplotype does not affect human brain structure and function in a sample of community-dwelling older adults. PLoS One. 2017 Aug 3;12(8):e0181392. doi: 10.1371/journal.pone.0181392. eCollection 2017.
citation: Patel R, Mackay CE, Jansen MG, Devenyi GA, O'Donoghue MC, Kivimaki M, Singh-Manoux A, Zsoldos E, Ebmeier KP, Chakravarty MM, Suri S. Inter- and intra-individual variation in brain structural-cognition relationships in aging. Neuroimage. 2022 Aug 15;257:119254. doi: 10.1016/j.neuroimage.2022.119254. Epub 2022 Apr 28.
citation: Jansen MG, Griffanti L, Mackay CE, Anaturk M, Melazzini L, Lange AG, Filippini N, Zsoldos E, Wiegertjes K, Leeuw FE, Singh-Manoux A, Kivimaki M, Ebmeier KP, Suri S. Association of cerebral small vessel disease burden with brain structure and cognitive and vascular risk trajectories in mid-to-late life. J Cereb Blood Flow Metab. 2022 Apr;42(4):600-612. doi: 10.1177/0271678X211048411. Epub 2021 Oct 5.
citation: Suri S, Chiesa ST, Zsoldos E, Mackay CE, Filippini N, Griffanti L, Mahmood A, Singh-Manoux A, Shipley MJ, Brunner EJ, Kivimaki M, Deanfield JE, Ebmeier KP. Associations between arterial stiffening and brain structure, perfusion, and cognition in the Whitehall II Imaging Sub-study: A retrospective cohort study. PLoS Med. 2020 Dec 29;17(12):e1003467. doi: 10.1371/journal.pmed.1003467. eCollection 2020 Dec.
citation: Zsoldos E, Mahmood A, Filippini N, Suri S, Heise V, Griffanti L, Mackay CE, Singh-Manoux A, Kivimaki M, Ebmeier KP. Association of midlife stroke risk with structural brain integrity and memory performance at older ages: a longitudinal cohort study. Brain Commun. 2020 Mar 7;2(1):fcaa026. doi: 10.1093/braincomms/fcaa026. eCollection 2020.