Clinical trial NCT06861075: CARPEUS : Effect of Carvedilol on the Portosystemic Gradient As Measured by Endoscopic Ultrasound
Official title: CARPEUS : Effect of Carvedilol on the Portosystemic Gradient As Measured by Endoscopic Ultrasound
Study type: INTERVENTIONAL
Overall status: NOT_YET_RECRUITING
Phase: NA
Conditions: Cirrhosis
Portal Hypertension Related to Cirrhosis
Keywords: Carvedilol.
Portal hypertension in cirrhosis.
EUS-PPG measurement.
Lead sponsor: University Hospital, Clermont-Ferrand
Sponsor class: OTHER
First posted: 2025-03-06
Enrollment: 30
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: TREATMENT

Brief summary: The purpose of this study is to assess the efficacy after one month of treatment with Carvedilol (12.5 mg daily) in primary prophylaxis of digestive haemorrhage due to portal hypertension in cirrhosis, by endoscopic ultrasound-guided portal pressure gradient measurement.

Detailed description: After being informed about the study and potential risks, all patients giving written informed consent will undergo a screening period to determine eligibility for entry study.

- Inclusion visit (day 1) includes an oesogastroduodenal fibroscopy (OGDF) followed by an endoscopic ultrasound-guided portal pressure gradient (EUS-PPG) measurement, an electrocardiogram, a clinical examination, and a first intake of study treatment : Carvedilol 3.125 mg.

Carvedilol, day 2 to day 8: 6.25 mg/day (3.125 mg twice a day). - Visit 2 (day 6 +/- 2 days): clinical examination, record of potential adverse events, vital signs (arterial pressure, pulse rate), electrocardiogram if indicated, assessment of compliance with study treatment.

Carvedilol, day 9 to day 90 (end of study visit): 12.5 mg/day (6.25 mg twice a day).

- Visit 3 (day 13 +/- 2 days): clinical examination, record of potential adverse events, vital signs (arterial pressure, pulse rate), electrocardiogram if indicated, assessment of compliance with study treatment.

Carvedilol will be continued at the dose of 12.5 mg/day, on a long-term basis. - Visit 4 (day 30-45): OGDF followed by an EUS-PPG measurement, clinical examination, record of potential adverse events, vital signs (arterial pressure, pulse rate), electrocardiogram if indicated, assessment of compliance with study treatment.

Carvedilol will be continued at the dose of 12.5 mg/day.

- Visit 5 (day 90 +/- 7 jours), end of study visit: clinical examination, record of potential adverse events, vital signs (arterial pressure, pulse rate), electrocardiogram, assessment of compliance with study treatment.

Treatment with Carvedilol will be prescribed by a cardiologist and continued at the dose of 12.5 mg/day.

Follow-up of the patient according to standard practice. NB: an adaptation of the dose of Carvedilol may be considered according to tolerability, throughout the study.

Eligibility criteria: Inclusion Criteria:

Patients ≥ 18 years

Suspected portal hypertension associated with cirrhosis (of any aetiology) as defined by Baveno VII criteria :

Liver stiffness ≥ 25 kPa Or Liver stiffness between 20 and 25 kPa and platelets \< 150 G/L Or Liver stiffness between 15 and 20 kPa and platelets \< 110 G/L

Or Oesophageal varices with high risk of bleeding :

Size \> 5 mm (stage 2 or 3) Or Size ≤ 5 mm and red spots Or Size ≤ 5 mm and Child-Pugh score C Patients naive to treatment with cardioselective beta blockers Affiliated to french health insurance system

Exclusion Criteria:

* Absolute contraindications to beta blockers :

  * hypersensitivity to the active substance (carvedilol) or to any of the excipients listed in section 6.1 of the summary of product characteristics
  * patients with severe decompensated heart failure, with signs of fluid overload (oedema, ascites, pulmonary stasis rales), and/or requiring treatment with a positive inotrope or venous vasodilator
  * second and third-degree atrioventricular blocks (unless presence of a permanent pacemaker)
  * severe bradycardia (≤ 50 bpm)
  * cardiac sinus disease (including sino-auricular block)
  * severe hypotension (systolic pressure \< 85 mm Hg)
  * cardiogenic shock
  * severe asthma, severe chronic obstructive pulmonary disease, history of severe bronchospasm
  * history of anaphylactic reaction
  * Raynaud's phenomenon
  * peripheral circulatory disorder: severe obliterative arterial disease of the lower limbs
  * association with cimetidine
  * association with class I antiarrhythmics except lidocaine
  * pulmonary arterial hypertension
* BMI ≥ 30 kg/m2 in NASH cirrhosis.
* Current hepatic encephalopathy ≥ Grade 2.
* Ongoing hepato-renal syndrome.
* Profuse clinical ascites.
* History of oesophageal varices rupture.
* Hepatocellular carcinoma active or in remission for less than six months.
* Active or resolved portal vein thrombosis for less than six months.
* History of digestive surgery that does not allow the porto-systemic gradient to be measured using echo-endoscopy (gastrectomy, by-pass, etc.).
* Patients taking antiaggregants (except acetylsalicylic acid) or anticoagulants for embologenic CA/FA.
* Severe stage 4 chronic renal insufficiency or stage 5 end-stage renal insufficiency (clearance \< 30 mL/min).
* Pregnant or breast-feeding women, or those planning to become pregnant\*.

  \*A pregnancy test will be carried out for women of childbearing potential, and the investigator will ensure that effective contraception is in place while Carvedilol is being taken and for 5 half-lives after stopping it.
* Patients protected by law (under guardianship, curatorship or safeguard of justice) or deprived of their freedom.
* Patients currently taking part in another clinical research protocol.
* Patients who do not understand French language.

Primary outcomes:
measure: Percentage of participants with a reduction of at least 10% in the porto-systemic gradient
timeFrame: One month after starting carvedilol.
Secondary outcomes:
measure: Side-effects of beta blockers
timeFrame: From enrollment to D90.
measure: Number of participants with digestive hemorrhage
timeFrame: Within three months of starting Carvedilol.
Other outcomes:
Locations:
city: Clermont-Ferrand
country: France
facility: Lise Laclautre
Study officials:
affiliation: University Hospital, Clermont-Ferrand
name: Laurent Poincloux
role: PRINCIPAL_INVESTIGATOR
References: