louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT01629342: Standardized Physical Activities Measured by Accelerometers
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Transient Ischemic Attack
Lead sponsor: Hillerod Hospital, Denmark
Sponsor class: OTHER
First posted: 2012-06-27
Enrollment: 25
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Patients just prior discharge from Stoke Unit, Neurologic Department, Hillerød Hospital

Brief summary: STANDARDIZED PHYSICAL ACTIVITIES MEASURED BY ACCELEROMETERS Background and aims: Physical activity may be assessed by several different methods. However, the use of accelerometers is the most direct method available for real-time measurements. The piezoelectric element of accelerometers records an electric voltage during movement which is then transcribed to Activity Counts (AC). Few studies have used Actical accelerometers to assess standardized physical activities and most of these were not applicable to patients in a hospital setting. No previous studies have applied Actical accelerometers to the wrists or ankles during standardized activities. The aim of this study is to record AC during different standardized activities frequently done by patients hospitalized for acute ischemic stroke.

Methods: Patients discharged since February 2012 after a transient ischemic attack have been invited to participate in the study scheduled for June-September 2012 (nexpected=25). All participants wear 5 accelerometers (Actical), one at each wrist and ankle and one over the hip. Standardized physical activities include:

* treadmill walking (5 minutes, 1 and 4km/h)
* staircase walking (1 floor, normal pace)
* cycling with fixed load (5 minutes)
* standing up from sitting position and sitting down again (x5)
* standing up from supine position
* turning from left to right and back while lying in bed
* raising outstretched arm 90° (x5, standing position)
* eating (5 minutes, sitting position)
* drinking a glass of water
* sleeping (6 hours)


Eligibility criteria: Inclusion Criteria:

* Previous Transient Ischemic Attack
* age \> 18 years

Exclusion Criteria:

* pregnancy and lactation
* time limit of more than 2 days of standardized activities exceeded
* no informed consent
* disability when tested with Scandinavian Stroke Scale (score \<58), National Institutes of Health Stroke Scale (score \>0), modified Rankin Scale (score \>0) and Barthels Index 100 (score \<100)

Primary outcomes:
measure: Activity
timeFrame: 2 days
Secondary outcomes:
Other outcomes:
Locations:
city: Hillerød
country: Denmark
facility: Neurologic Department, Hillerød Hospital
Study officials:
References:
Clinical trial NCT05412342: Characterizing the Association Between Preoperative Depressive Symptoms and Opioid Use/Misuse After Surgery
Official title: Observational Study to Characterize the Relationship Between Preoperative Depressive Symptoms and Opioid Use/Misuse After Surgery
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Opioid Use
Lead sponsor: Stanford University
Sponsor class: OTHER
First posted: 2022-06-09
Enrollment: 718
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Patients undergoing elective surgery at Stanford Hospital.

Brief summary: This observational study aims to characterize the relationship between preoperative depressive symptoms and opioid use/ misuse after surgery using a perioperative learning health care system. We will follow a prospective cohort of patients undergoing elective surgery.


Eligibility criteria: Inclusion Criteria:

1. Age 18+
2. Planning to undergo surgery
3. English speaking
4. Ability and willingness to complete questionnaires and assessments

Exclusion Criteria:

1. Any conditions causing inability to complete assessments (education, cognitive ability, mental status, medical status)
2. Known Pregnancy
3. Elevated Suicidality
4. Enrollment in a conflicting perioperative trial

Primary outcomes:
measure: Time to Opioid Cessation
timeFrame: Assessed after surgery up to 1 year
Secondary outcomes:
measure: Opioid Misuse
timeFrame: Assessed after surgery up to 1 year
Other outcomes:
Locations:
city: Palo Alto
country: United States
facility: Stanford University School of Medicine
state: California
city: Stanford
country: United States
facility: Stanford Health Care
state: California
Study officials:
References:
Clinical trial NCT02924142: Treatment Outcomes After Receiving Conventional Clasp or Precision Attachment Removable Partial Dentures.
Official title: Treatment Outcomes Based on Patient's Oral Health Related Quality of Life (OHRQoL) After Receiving Conventional Clasp or Precision Attachment Removable Partial Dentures in Distal Extension Cases: A Randomized Controlled Clinical Trial
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Bilateral Edentulous Mandible (Kennedy Class I)
Keywords: Kennedy classification for edentulous ridge
Lead sponsor: Cairo University
Sponsor class: OTHER
First posted: 2016-10-05
Enrollment: 32
Sex: ALL
Minimum age (years): 50
Maximum age (years): 75
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: PICOTS:

P: Kennedy class І patients

I : Mandibular removable partial denture with OT Cap attachment

C: Mandibular removable partial denture with gingival approaching clasp assembly

O: 1ry outcome: Oral Health Related Quality of Life

2ry outcome: Biting force

T: 1 Year

S : Randomized control trial

Research question:

In Kennedy class І patients will the removable partial denture with OT Cap attachment compared to conventional removable partial denture with clasp assembly results in difference in Oral Health Related Quality of Life of Patients?

Detailed description: In bilateral edentulous mandible with missing molars, the clasp retained partial denture will be compared with precision attachment partial denture for better quality of life for patients.

Eligibility criteria: Inclusion Criteria:

1. Patients with mandibular free end saddle cases.
2. Patients less than 75 years old.
3. Patients who approved to be included in the trial and signed the informed consent.
4. Patients are not suffering from diabetes mellitus.

Exclusion Criteria:

1. Patients are suffering from diabetes mellitus.
2. Patients above 75 years old.
3. Patients are receiving chemotherapy or radiotherapy.
4. Patients with severe Temporomandibular Joint problems.
5. Patients who refused the trial.

Primary outcomes:
measure: Oral Health Related Quality of Life
timeFrame: 1 Year
Secondary outcomes:
measure: Biting force
timeFrame: 1 Year
Other outcomes:
Locations:
city: Cairo
country: Egypt
facility: Faculty of Oral and Dental Medicine, Cairo University
Study officials:
affiliation: Faculty of Oral and Dental Medicine, Cairo University, Cairo, Egypt
name: Yousr M. Mady, Professor
role: STUDY_DIRECTOR
affiliation: Faculty of Oral and Dental Medicine, Cairo University, Cairo, Egypt
name: Ahmed M. Fayyad, A. Professor
role: STUDY_DIRECTOR
References:
Clinical trial NCT05335642: Secondary Intervention and Surveillance After EVAR
Official title: Secondary Intervention and Surveillance After Abdominal Aortic Aneurysm Endovascular Repair: Retrospective Cohort Study
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Abdominal Aortic Aneurysm Without Rupture
Lead sponsor: Hospital Sao Joao
Sponsor class: OTHER
First posted: 2022-04-19
Enrollment: 214
Sex: ALL
Minimum age (years): 18
Maximum age (years): 100
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: RETROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: Consecutive patients submitted to elective EVAR in a university center.

Brief summary: This is a retrospective cohort study of consecutive patients submitted to elective EVAR, between February/2009 and May/2019 in a single institution. Symptomatic or ruptured AAA, mycotic aneurysms, isolated iliac aneurysms and complex abdominal aortic repairs were excluded. The primary outcomes were freedom from secondary intervention and compliance with follow-up, defined as surveillance imaging performed within a periodicity no longer than 18 months.


Eligibility criteria: Inclusion Criteria:

* This is a retrospective cohort study of consecutive patients submitted to elective EVAR, between February/2009 and May/2019 in a single institution.

Exclusion Criteria:

* Symptomatic or ruptured AAA, mycotic aneurysms, isolated iliac aneurysms and complex abdominal aortic repairs were excluded.

Primary outcomes:
measure: Number of participant with secondary intervention (SI) after EVAR
timeFrame: 5 years follow up
Secondary outcomes:
measure: Number of participant with compliance with follow-up after EVAR
timeFrame: 5 years follow up
Other outcomes:
Locations:
city: Porto
country: Portugal
facility: Marina Felicidade Dias Neto
state: State/Province
Study officials:
References:
Clinical trial NCT04577742: Uveal Melanoma and Brachytheraphy: Long-term Outcomes.
Official title: Long-term Outcomes in Uveal Melanoma After Ruthenium-106 Brachytherapy
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: 106 Ruthenium Plaque Brachytherapy
Uveal Melanoma
Lead sponsor: Federico II University
Sponsor class: OTHER
First posted: 2020-10-08
Enrollment: 350
Sex: ALL
Minimum age (years): 40
Maximum age (years): 80
Standard ages: ADULT
OLDER_ADULT
Observational model: COHORT
Time perspective: RETROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: The participans were older than 40 years with uveal melanoma and they underwent Ruthenium 106 brachytherapy

Brief summary: This study investigated the visual and anatomical outcomes, tumor control, tumor recurrence, distant metastasis and cancer free survival in patients affected by uveal melanoma and undergoing Ru-106 plaque brachytherapy between February 2011 and March 2020


Eligibility criteria: Inclusion Criteria:

* age older than 40 years
* diagnosis of uveal melanoma

Exclusion Criteria:

* age older than 80 years
* No diagnosis of uveal melanoma

Primary outcomes:
measure: To evaluate long-term outcomes in patients underwent brachytherapy for uveal melanoma
timeFrame: Mean follow-up was 4 years (3 months-9 years)
Secondary outcomes:
Other outcomes:
Locations:
city: Naples
country: Italy
facility: University of Naples "Federico II"
Study officials:
References:
Clinical trial NCT02788942: The Removing Port of the Laparoscopic Cholecystectomy Material
Official title: The Relationship Between the Removing Port of the Laparoscopic Cholecystectomy Material and the Port Site Infections
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Wound Infection
Keywords: Port
Infection
cholecystectomy
Lead sponsor: Sisli Hamidiye Etfal Training and Research Hospital
Sponsor class: OTHER
First posted: 2016-06-02
Enrollment: 120
Sex: ALL
Minimum age (years): 18
Maximum age (years): 80
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: SCREENING

Brief summary: Laparoscopic cholecystectomy is gold standard for gallstones. In this study the investigators are investigating the effect of the removing of cholecystectomy material from different ports, to the port site infections.

Detailed description: Laparoscopic cholecystectomy is gold standard for gallstones. But there is no consensus about which port place is optimal for the removing of the cholecystectomy material from the abdomen. There are different port site infections rates in the literature. The minimal tissue damage of laparoscopic cholecystectomy suggests a lower risk of wound infection, but there are series with an infection range of 8 %. The investigators are investigating is there any difference at the port site infection rates when the cholecystectomy material removed from different ports from the abdomen at the laparoscopic cholecystectomy.

Eligibility criteria: Inclusion Criteria:

* Subject has cholelithiasis

Exclusion Criteria:

* Subject has perforated gallbladder
* Subject has malignancy
* Subject has increasing wall thickness of the gallbladder
* Subject has malignancy in the preoperative ultrasonography in the gallbladder
* Subject has pregnancy

Primary outcomes:
measure: Port site infections
timeFrame: 2 days
Secondary outcomes:
Other outcomes:
Locations:
city: Istanbul
country: Turkey
facility: Sisli Etfal Training and Research Hospital
Study officials:
affiliation: Sisli Etfal Training and Research Hospital
name: Cemal Kaya
role: PRINCIPAL_INVESTIGATOR
References:
citation: Comajuncosas J, Hermoso J, Jimeno J, Gris P, Orbeal R, Cruz A, Pares D. Effect of bag extraction to prevent wound infection on umbilical port site wound on elective laparoscopic cholecystectomy: a prospective randomised clinical trial. Surg Endosc. 2017 Jan;31(1):249-254. doi: 10.1007/s00464-016-4965-z. Epub 2016 May 13.
citation: Farooq U, Rashid T, Naheed A, Barkat N, Iqbal M, Sultana Q. COMPLICATIONS OF LAPAROSCOPIC CHOLECYSTECTOMY: AN EXPERIENCE OF 247 CASES. J Ayub Med Coll Abbottabad. 2015 Apr-Jun;27(2):407-10.
citation: Comajuncosas J, Hermoso J, Gris P, Jimeno J, Orbeal R, Vallverdu H, Lopez Negre JL, Urgelles J, Estalella L, Pares D. Risk factors for umbilical trocar site incisional hernia in laparoscopic cholecystectomy: a prospective 3-year follow-up study. Am J Surg. 2014 Jan;207(1):1-6. doi: 10.1016/j.amjsurg.2013.05.010. Epub 2013 Oct 7.
Clinical trial NCT06431542: Efficacy of Self Vs. Physician Application of Triamcinolone-Econazole in Otomycosis
Official title: Comparison of the Efficacy of Patient Self-Application Versus Physician Application of Triamcinolone Acetonide Econazole Cream in the Treatment of Otomycosis
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE4
Conditions: Otomycosis
Keywords: triamcinolone acetonide econazole cream
otomycosis
Lead sponsor: Zhongshan Hospital Xiamen University
Sponsor class: OTHER
First posted: 2024-05-28
Enrollment: 200
Sex: ALL
Minimum age (years): 4
Maximum age (years): 100
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: to analyze the clinical characteristics, types of Fungal Infections, and comparison of the efficacy of patient self-application versus physician application of triamcinolone acetonide econazole cream in otomycosis treatment.

Detailed description: The study analyzes the clinical characteristics, including symptoms and physical examinations, as well as the types of fungal infections. It compares the efficacy of patient self-application versus physician application of triamcinolone acetonide econazole cream in treating otomycosis two weeks after starting treatment. Furthermore, the study also compares the recurrence rates six months after treatment.

Eligibility criteria: Inclusion Criteria:

* 1.The chief complaint was ear discomfort, including tinnitus, a feeling of blockage or fullness, pruritis, otalgia, otorrhea and decreased hearing; 2. Physical examination findings:presence of fungal hyphae or accumulations that appear creamy or cheese-like or resembling abnormal earwax (crusts, films) , skin redness, erosion, swelling, or granulation tissue within the ear canal; 3. Positive results in fungal culture.

Exclusion Criteria:

* The exclusion criteria included otitis media, tympanic membrane perforation, and conditions post-radiotherapy.

Primary outcomes:
measure: treatment efficacy
timeFrame: 2 weeks
Secondary outcomes:
measure: recurrece rate
timeFrame: 3 months
Other outcomes:
Locations:
city: Xiamen
country: China
facility: Xiamen University Zhongshan Hospital
state: Fujian
Study officials:
affiliation: Xiamen University Zhongshan Hospital
name: Chunsheng Chunsheng
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT01989442: Nasal Mask and Prong Use in Non-invasive Ventilation for Newborns
Official title: Efficacy and Safety of Nasal Mask and Prong Use in Non-invasive Ventilation for Newborns
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Bronchopulmonary Dysplasia
Keywords: cpap failure
bronchopulmonary dysplasia
nasal trauma
ventilation duration
non-invasive ventilation
Lead sponsor: Ankara University
Sponsor class: OTHER
First posted: 2013-11-21
Enrollment: 100
Sex: ALL
Maximum age (years): 28
Standard ages: CHILD
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The study aims to investigate efficacy and safety of nasal mask and prongs used in non-invasive ventilation in newborns by using esophageal pressure transducer.

The parameters including ventilation duration, hospitalization duration, pulmonary outcomes and side effects will be evaluated.

Detailed description: Although it seems as more non-invasive there is still lack of data especially on efficacy of nasal mask use in NIV for newborns. By using esophageal pressure transducers we will evaluate the pressure supplied by the ventilation mode and compare it with more commonly used nasal prongs. The investigators will test the hypothesis of equivalence of nasal mask in comparison to prongs with better safety parameters.

Eligibility criteria: Inclusion Criteria:

* all newborns who require NIV as first line treatment as respiratory support in delivery room or neonatal intensive care unit

Exclusion Criteria:

* who are intubated in delivery room or neonatal intensive care unit before randomization
* with congenital anomaly
* patients who require NIV more than 3 days

Primary outcomes:
measure: failure of NIV
timeFrame: 1 year
Secondary outcomes:
measure: ventilation duration
timeFrame: 3 days
Other outcomes:
measure: bronchopulmonary dysplasia
timeFrame: 1 year
measure: septal trauma rate
timeFrame: 1 year
Locations:
city: Ankara
country: Turkey
facility: Ankara University
Study officials:
affiliation: Ankara University
name: Saadet ARSAN, Professor
role: PRINCIPAL_INVESTIGATOR
References:
citation: McCarthy LK, Twomey AR, Molloy EJ, Murphy JF, O'Donnell CP. A randomized trial of nasal prong or face mask for respiratory support for preterm newborns. Pediatrics. 2013 Aug;132(2):e389-95. doi: 10.1542/peds.2013-0446. Epub 2013 Jul 29.
citation: Kieran EA, Twomey AR, Molloy EJ, Murphy JF, O'Donnell CP. Randomized trial of prongs or mask for nasal continuous positive airway pressure in preterm infants. Pediatrics. 2012 Nov;130(5):e1170-6. doi: 10.1542/peds.2011-3548. Epub 2012 Oct 22.
Clinical trial NCT02616042: The Effect of New Dentifrices Containing Centella Asiatica and Bamboo Salt on Reducing Plaque and Gingivitis
Official title: The Effect of New Dentifrices Containing Centella Asiatica and Bamboo Salt on Reducing Plaque and Gingivitis: a Randomized Clinical Trial
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE3
Conditions: Labor Trial Refused
Keywords: Centella asiatica
bamboo salt
dentifrice
Lead sponsor: LG Household & Health Care Ltd.
Sponsor class: INDUSTRY
Collaborators: name: Seoul National University
First posted: 2015-11-26
Enrollment: 33
Sex: ALL
Minimum age (years): 18
Maximum age (years): 40
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: CROSSOVER
Primary purpose: PREVENTION

Brief summary: This study aims to evaluate the effect of dentifrice formulations containing Centella asiatica and bamboo salt on gingivitis and dental plaque. Participants uses dentifrice which contains Centella asiatica and bamboo salt and the same participants will also use placebo for tooth brushing by cross-over design.

Detailed description: With growing interest in plant-based products among researchers, many toothpastes with various herbal extracts have been introduced over the past few decades,Centella asiatica (CA), a small herb broadly cultivated in China, Southeast Asia, India and Oceanic countries, has long been used for therapeutic purposes since ancient times.CA has been reported to be useful in the treatment of skin diseases wound repair and healing of burn. In dentistry, few studies have explored the efficacy of CA. In one study, CA was demonstrated to be an effective supportive agent following periodontal treatment, resulting in reduced plaque and gingivitis. In spite of such wound healing properties of CA, its usage in dental field has been limited.

Bamboo salt (BS) is a Korean folk remedy consisting of sea salt roasted in bamboo which has long been used for therapeutic purposes in Korea. Toothpastes containing BS has been sold in Korea for some decades. Some in vitro studies and animal studies using rats demonstrated anti-inflammatory effects of BS. Nevertheless, no human study has yet evaluated the effect of BS on periodontal health.

Therefore, the new dentifrice containing CA and BS was developed.

Eligibility criteria: Inclusion Criteria:

* Systemical healthy individual
* Normal alignment of teeth

Exclusion Criteria:

* Recent antibiotic treatment
* Existence of dental caries or periodontitis
* Those needs emergency dental treatments
* Natural teeth less than 20
* Denture wearer
* Oral appliance for orthodontic treatment
* Pregnant

Primary outcomes:
measure: Gingivitis
timeFrame: Four day
Secondary outcomes:
measure: Dental plaque
timeFrame: Four day
Other outcomes:
Locations:
Study officials:
affiliation: Seoul National University
name: Hyun-Duck Kim, DDS, PhD
role: PRINCIPAL_INVESTIGATOR
References: