Clinical trial NCT02543424: Motor and Cognitive Functions in Acquired and Developmental Brain Damaged Patients
Official title: Studies of the Diagnosis, Rehabilitation and Links Between Motor and Cognitive Functions in Acquired and Developmental Brain Damaged Patients
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Cerebral Palsy
Perceptual Disorders
Hemiparesis
Lead sponsor: Cliniques universitaires Saint-Luc- Université Catholique de Louvain
Sponsor class: OTHER
First posted: 2015-09-07
Enrollment: 400
Sex: ALL
Minimum age (years): 5
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: NON_RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: Neurological pathologies cause important and permanent disabilities in every day life. These pathologies can follow stoke, affecting two people per one thousand each year or cerebral palsy, affecting two births per one thousand each year. To date, the diagnosis and the rehabilitation of motor and cognitive problems has been carried out separately by different domains. For example, physiotherapists have focused on motor problems and neuropsychologists have focused on cognitive functions. However, a number of studies have demonstrated a link between motor and cognitive abilities in adults and children. The present study has three main aims: (1) to better evaluate motor and cognitive problems in brain damaged patients (all ages), (2) to understand the link between motor and cognitive abilities in patients and healthy participants and, (3) to propose new types of therapies based on the link between motor and cognitive functions.


Eligibility criteria: Inclusion Criteria:

* Congenital cerebral palsy and acquired brain injury children and adult patients
* Presenting upper limb paresis and/or hemineglect
* Between the age of 3 to 90.
* Able to understand and carry out simple verbal instruction

Exclusion Criteria:

* IQ \< 70
* Severe aphasia, attentional disorder or psychiatric disorders
* Neurodegenerative disorders

Primary outcomes:
measure: Kinematics
timeFrame: Change from Baseline (T0) in kinematics at an expected average of 1 week (T1), 2 months (T2) and 3 months (T3).
Secondary outcomes:
measure: Standardized cognitive and motor assessment
timeFrame: Change from Baseline (T0) in cognitive and motor assessment at an expected average of 1 week (T1), 2 months (T2) and 3 months (T3).
Other outcomes:
Locations:
city: Ottignies
country: Belgium
facility: Centre Hospitalier Neurologique William Lennox
state: Brabant Wallon
city: Woluwé-Saint-Lambert
country: Belgium
facility: Cliniques Universitaires St Luc
state: Bruxelles
Study officials:
affiliation: St. Luc Hospital
name: Thierry Lejeune
role: PRINCIPAL_INVESTIGATOR
affiliation: St. Luc Hospital
name: Gaëtan Stoquart
role: PRINCIPAL_INVESTIGATOR
affiliation: Université Catholique de Louvain
name: Martin Edwards
role: PRINCIPAL_INVESTIGATOR
References:
citation: Dehem S, Montedoro V, Brouwers I, Edwards MG, Detrembleur C, Stoquart G, Renders A, Heins S, Dehez B, Lejeune T. Validation of a robot serious game assessment protocol for upper limb motor impairment in children with cerebral palsy. NeuroRehabilitation. 2019;45(2):137-149. doi: 10.3233/NRE-192745.
citation: Montedoro V, Alsamour M, Dehem S, Lejeune T, Dehez B, Edwards MG. Robot Diagnosis Test for Egocentric and Allocentric Hemineglect. Arch Clin Neuropsychol. 2019 Jun 1;34(4):481-494. doi: 10.1093/arclin/acy062.