Clinical trial NCT03104400: A Study Comparing Upadacitinib (ABT-494) to Placebo and to Adalimumab in Participants With Psoriatic Arthritis Who Have an Inadequate Response to at Least One Non-Biologic Disease Modifying Anti-Rheumatic Drug (DMARD)
Official title: A Phase 3, Randomized, Double-Blind, Study Comparing Upadacitinib (ABT-494) to Placebo and to Adalimumab in Subjects With Active Psoriatic Arthritis Who Have a History of Inadequate Response to at Least One Non-Biologic Disease Modifying Anti-Rheumatic Drug (DMARD) - SELECT - PsA 1
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE3
Conditions: Psoriatic Arthritis
Keywords: Arthritis
Psoriasis
Anti-inflammatory
Joint disease
Musculoskeletal disease
Anti-Rheumatic
Lead sponsor: AbbVie
Sponsor class: INDUSTRY
First posted: 2017-04-07
Enrollment: 1705
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: This study includes two periods. The main objective of Period 1 is to compare the efficacy of upadacitinib 15 mg once daily (QD) and 30 mg QD versus placebo and versus adalimumab (Humira®) in participants with moderately to severely active psoriatic arthritis (PsA) who have had an inadequate response to non-biologic DMARDs (DMARD-IR). Period 1 is also designed to compare the efficacy of upadacitinib 15 mg and 30 mg QD versus placebo for the prevention of structural progression.

The objective of Period 2 is to evaluate the long-term safety, tolerability and efficacy of upadacitinib 15 mg and 30 mg QD in participants who have completed Period 1.

Detailed description: The study includes a 35-day screening period, a 56-week blinded period (Period 1), a long-term extension period of up to a total treatment duration of approximately 5 years (Period 2), a 30-day follow-up call or visit, and a 70-day follow-up call.

Period 1 includes 24 weeks of randomized, double-blind, placebo-controlled and active comparator-controlled treatment followed by 32 weeks of active comparator-controlled upadacitinib; at Week 24 participants assigned to placebo will be switched to upadacitinib according to their randomization assignment.

Participants who meet eligibility criteria will be randomized in a 2:2:2:1:1 ratio to one of five treatment groups:

* Group 1: Upadacitinib 15 mg QD
* Group 2: Upadacitinib 30 mg QD
* Group 3: Adalimumab 40 mg every other week (EOW)
* Group 4: Placebo followed by upadacitinib 15 mg QD
* Group 5: Placebo followed by upadacitinib 30 mg QD

Randomization will be stratified by extent of psoriasis (≥ 3% body surface area \[BSA\] or \< 3% BSA), current use of at least 1 non-biologic DMARD, presence of dactylitis, and presence of enthesitis, except for participants from China and Japan, where randomization for each country will be stratified by extent of psoriasis (≥ 3% BSA or \< 3% BSA) only.

Participants who complete the Week 56 visit (end of Period 1) will enter the long-term extension portion of the study, Period 2 (total treatment up to approximately 5 years), and continue study treatment as assigned in Period 1 in a blinded manner until the last subject completes the last visit of Period 1 (Week 56), when study drug assignment in both periods will be unblinded and participants will be dispensed study drug in an open-label fashion until the completion of Period 2.

At Week 16, rescue therapy will be offered to participants classified as non-responders (defined as not achieving at least 20% improvement in tender joint count (TJC) and / or swollen joint count (SJC) at both Week 12 and Week 16). Starting at Week 36, participants who fail to demonstrate at least 20% improvement in either or both TJC and SJC compared to Baseline at 2 consecutive visits will be discontinued from study drug treatment. Additionally, in participants continuing on study drug, starting at the Week 36 visit, initiation of or change in background PsA medication(s) is allowed as per local label.

Eligibility criteria: Inclusion Criteria:

* Clinical diagnosis of PsA with symptom onset at least 6 months prior to the Screening Visit and fulfillment of the Classification Criteria for PsA (CASPAR) criteria.
* Participant has active disease at Baseline defined as \>= 3 tender joints (based on 68 joint counts) and \>= 3 swollen joints (based on 66 joint counts) at Screening and Baseline Visits.
* Presence of either at Screening:

  1. \>= 1 erosion on x-ray as determined by central imaging review or;
  2. high-sensitivity C-reactive protein (hs-CRP) \> laboratory defined upper limit of normal (ULN).
* Diagnosis of active plaque psoriasis or documented history of plaque psoriasis.
* Participant has had an inadequate response (lack of efficacy after a minimum 12 week duration of therapy) to previous or current treatment with at least 1 non-biologic DMARD at maximally tolerated dose (methotrexate (MTX), sulfasalazine (SSZ), leflunomide (LEF), cyclosporine, apremilast, bucillamin or iguratimod), or participant has an intolerance to or contraindication for DMARDs as defined by the investigator.
* Participant who is on current treatment with concomitant non-biologic DMARDs at study entry must be on \<= 2 non-biologic DMARDs (except the combination of MTX and leflunomide). The following non-biologic DMARDs are allowed: MTX, sulfasalazine, leflunomide, apremilast, hydroxychloroquine (HCQ) , bucillamine or iguratimod, and have been ongoing for \>= 12 weeks and at stable dose for \>= 4 weeks prior to the Baseline Visit. No other DMARDs are permitted during the study.

  i. Participants who need to discontinue DMARDs prior to the Baseline Visit to comply with this inclusion criterion must follow the procedure specified below or at least five times the mean terminal elimination half-life of a drug:
  1. \>= 8 weeks for LEF if no elimination procedure was followed, or adhere to an elimination procedure (i.e., 11 days with cholestyramine, or 30 days washout with activated charcoal or as per local label);
  2. \>= 4 weeks for all others.

     Exclusion Criteria:
* Prior exposure to any Janus Kinase (JAK) inhibitor (including but not limited to ruxolitinib, tofacitinib, baricitinib, and filgotinib).
* Current treatment with \> 2 non-biologic DMARDs; or use of DMARDs other than methotrexate, sulfasalazine, leflunomide, apremilast, hydroxychloroquine, bucillamine, or iguratimod; or use of methotrexate in combination with leflunomide.
* History of fibromyalgia, any arthritis with onset prior to age 17 years, or current diagnosis of inflammatory joint disease other than PsA (including, but not limited to rheumatoid arthritis, gout, overlap connective tissue diseases, scleroderma, polymyositis, dermatomyositis, systemic lupus erythematosus). Prior history of reactive arthritis or axial spondyloarthritis including ankylosing spondylitis and nonradiographic axial spondyloarthritis is permitted if documentation of change in diagnosis to PsA or additional diagnosis of PsA is made. Prior history of fibromyalgia is permitted if documentation of change in diagnosis to PsA or documentation that the diagnosis of fibromyalgia was made incorrectly.

Primary outcomes:
measure: Percentage of Participants With an American College of Rheumatology 20% (ACR20) Response at Week 12
timeFrame: Baseline and Week 12
Secondary outcomes:
measure: Change From Baseline in Health Assessment Questionnaire Disability Index (HAQ-DI) at Week 12
timeFrame: Baseline and Week 12
measure: Percentage of Participants Achieving a Static Investigator Global Assessment (sIGA) of Psoriasis of 0 or 1 and at Least a 2-point Improvement From Baseline (sIGA 0/1) at Week 16
timeFrame: Baseline and Week 16
measure: Percentage of Participants Achieving Psoriasis Area Severity Index (PASI) 75 Response at Week 16
timeFrame: Baseline and Week 16
measure: Change From Baseline in Modified PsA Total Sharp/Van Der Heijde Score (mTSS) at Week 24
timeFrame: Baseline and Week 24
measure: Percentage of Participants Achieving Minimal Disease Activity (MDA) at Week 24
timeFrame: Week 24
measure: Percentage of Participants With Resolution of Enthesitis at Week 24
timeFrame: Week 24
measure: Percentage of Participants With an ACR20 Response at Week 12 - Non-inferiority Versus Adalimumab
timeFrame: Baseline and Week 12
measure: Change From Baseline in Short-Form 36 (SF-36) Physical Component Score (PCS) at Week 12
timeFrame: Baseline and Week 12
measure: Change From Baseline in Functional Assessment of Chronic Illness Therapy-Fatigue (FACIT-F) Score at Week 12
timeFrame: Baseline and Week 12
measure: Percentage of Participants With an ACR20 Response at Week 12 - Superiority Versus Adalimumab
timeFrame: Baseline and Week 12
measure: Percentage of Participants With Resolution of Dactylitis at Week 24
timeFrame: Week 24
measure: Change From Baseline in Patient's Assessment of Pain - Superiority Versus Adalimumab
timeFrame: Baseline and Week 12
measure: Change From Baseline in HAQ-DI - Superiority Versus Adalimumab
timeFrame: Baseline and Week 12
measure: Change From Baseline in Self-Assessment of Psoriasis Symptoms (SAPS) Questionnaire at Week 16
timeFrame: Baseline and Week 16
measure: Percentage of Participants With an American College of Rheumatology 50% (ACR50) Response at Week 12
timeFrame: Baseline and Week 12
measure: Percentage of Participants With an American College of Rheumatology 70% (ACR70) Response at Week 12
timeFrame: Baseline and Week 12
measure: Percentage of Participants With an American College of Rheumatology 20% (ACR20) Response at Week 2
timeFrame: Baseline and Week 2
Other outcomes:
Locations:
city: Huntsville
country: United States
facility: Rheum Assoc of North Alabama /ID# 163231
state: Alabama
city: Peoria
country: United States
facility: SunValley Arthritis Center, Lt /ID# 161221
state: Arizona
city: Phoenix
country: United States
facility: AZ Arthritis and Rheumotology Research, PLLC /ID# 159981
state: Arizona
city: Phoenix
country: United States
facility: AZ Arthritis and Rheumotology Research, PLLC /ID# 160033
state: Arizona
city: Phoenix
country: United States
facility: AZ Arthritis and Rheumotology Research, PLLC /ID# 160036
state: Arizona
city: Phoenix
country: United States
facility: AZ Arthritis & Rheuma Research /ID# 160037
state: Arizona
city: Tucson
country: United States
facility: AZ Arth & Rheum Res /ID# 166381
state: Arizona
city: Little Rock
country: United States
facility: Little Rock Diagnostics Clinic /ID# 165161
state: Arkansas
city: Covina
country: United States
facility: Covina Arthritis Clinic /ID# 159891
state: California
city: Fullerton
country: United States
facility: St. Joseph Heritage Healthcare /ID# 159980
state: California
city: Hemet
country: United States
facility: C.V. Mehta MD, Med Corporation /ID# 161216
state: California
city: Huntington Beach
country: United States
facility: Care Access Research, Huntingt /ID# 160038
state: California
city: La Mesa
country: United States
facility: Kotha and Kotha /ID# 159823
state: California
city: La Mesa
country: United States
facility: TriWest Research Associates- La Mesa /ID# 159887
state: California
city: La Palma
country: United States
facility: Arthritis & Osteo Medical Ctr /ID# 166760
state: California
city: Los Angeles
country: United States
facility: University of California, Los Angeles /ID# 164542
state: California
city: Mather
country: United States
facility: VA Sacramento Medical Center /ID# 164196
state: California
city: San Leandro
country: United States
facility: East Bay Rheumatology Medical /ID# 166382
state: California
city: Upland
country: United States
facility: Inland Rheum Clin Trials Inc. /ID# 159828
state: California
city: Whittier
country: United States
facility: Medvin Clinical Research /ID# 160034
state: California
city: Denver
country: United States
facility: Denver Arthritis Clinic /ID# 159873
state: Colorado
city: Fort Collins
country: United States
facility: Arthritis and Rheum Clin N. CO /ID# 160039
state: Colorado
city: Lakewood
country: United States
facility: Colorado Arthritis Associates /ID# 159847
state: Colorado
city: Stamford
country: United States
facility: Stamford Therapeutics Consorti /ID# 165131
state: Connecticut
city: Clearwater
country: United States
facility: Clinical Res of West FL, Inc. /ID# 159829
state: Florida
city: Daytona Beach
country: United States
facility: International Medical Research - Daytona /ID# 160040
state: Florida
city: DeBary
country: United States
facility: Omega Research Maitland, LLC /ID# 164193
state: Florida
city: Miami Lakes
country: United States
facility: Precision Research Org, LLC /ID# 161287
state: Florida
city: Miami
country: United States
facility: LeJenue Research Associates /ID# 170965
state: Florida
city: Naples
country: United States
facility: Medallion Clinical Research Institute, LLC /ID# 161228
state: Florida
city: Ormond Beach
country: United States
facility: Millennium Research /ID# 159822
state: Florida
city: Palm Harbor
country: United States
facility: Arthritis Center, Inc. /ID# 163465
state: Florida
city: Pensacola
country: United States
facility: Gulf Region Clinical Res Inst /ID# 159851
state: Florida
city: Saint Petersburg
country: United States
facility: BayCare Medical Group /ID# 159792
state: Florida
city: Tamarac
country: United States
facility: W. Broward Rheum Assoc Inc. /ID# 161388
state: Florida
city: Tampa
country: United States
facility: Clinical Research of West Florida, Inc /ID# 160063
state: Florida
city: Tampa
country: United States
facility: University of South Florida /ID# 161286
state: Florida
city: Tampa
country: United States
facility: BayCare Medical Group, Inc. /ID# 159879
state: Florida
city: Zephyrhills
country: United States
facility: Florida Medical Clinic /ID# 159992
state: Florida
city: Idaho Falls
country: United States
facility: Institute of Arthritis Researc /ID# 165873
state: Idaho
city: Meridian
country: United States
facility: Advanced Clinical Research /ID# 159894
state: Idaho
city: Chicago
country: United States
facility: Great Lakes Clinical Trials /ID# 163435
state: Illinois
city: Rockford
country: United States
facility: OrthoIllinois /ID# 164546
state: Illinois
city: Skokie
country: United States
facility: Clinical Investigation Specialists - Skokie /ID# 160062
state: Illinois
city: Vernon Hills
country: United States
facility: Deerbrook Medical Associates /ID# 159804
state: Illinois
city: Bowling Green
country: United States
facility: Graves Gilbert Clinic /ID# 161285
state: Kentucky
city: Paducah
country: United States
facility: Four Rivers Clinical Research /ID# 159982
state: Kentucky
city: New Orleans
country: United States
facility: Ochsner Clinic Foundation-New Orleans /ID# 165672
state: Louisiana
city: Baltimore
country: United States
facility: Johns Hopkins University /ID# 167665
state: Maryland
city: Cumberland
country: United States
facility: Klein & Associates, M.D., P.A. /ID# 164013
state: Maryland
city: Wheaton
country: United States
facility: The Center for Rheumatology & Bone Research /ID# 159874
state: Maryland
city: Boston
country: United States
facility: Tufts Medical Center /ID# 165144
state: Massachusetts
city: Mansfield
country: United States
facility: Mansfield Health Center /ID# 159805
state: Massachusetts
city: Worcester
country: United States
facility: Clinical Pharmacology Study Gr /ID# 158700
state: Massachusetts
city: Ann Arbor
country: United States
facility: Univ of Michigan Hospitals /ID# 164014
state: Michigan
city: Grand Blanc
country: United States
facility: Aa Mrc Llc /Id# 159846
state: Michigan
city: Lansing
country: United States
facility: Advanced Rheumatology, PC /ID# 159893
state: Michigan
city: Lansing
country: United States
facility: Beals Institute PC /ID# 163128
state: Michigan
city: Saint Clair Shores
country: United States
facility: Shores Rheumatology, PC /ID# 159889
state: Michigan
city: Duluth
country: United States
facility: St. Luke's Hospital of Duluth /ID# 165671
state: Minnesota
city: Saint Louis
country: United States
facility: Clayton Medical Associates dba Saint Louis Rheumatology /ID# 159878
state: Missouri
city: Springfield
country: United States
facility: Clinvest Research LLC /ID# 161227
state: Missouri
city: Kalispell
country: United States
facility: Glacier View Research Institut /ID# 167023
state: Montana
city: Omaha
country: United States
facility: Westroads Clinical Research /ID# 159979
state: Nebraska
city: Lebanon
country: United States
facility: Dartmouth-Hitchcock Medical Center /ID# 161235
state: New Hampshire
city: Freehold
country: United States
facility: Arthritis and Osteoporosis Associates /ID# 159802
state: New Jersey
city: Toms River
country: United States
facility: Atlantic Coast Research /ID# 159799
state: New Jersey
city: Toms River
country: United States
facility: Ocean Rheumatology, PA /ID# 163898
state: New Jersey
city: Las Cruces
country: United States
facility: Arthritis and Osteo Assoc /ID# 159994
state: New Mexico
city: Santa Fe
country: United States
facility: Santa Fe Rheumatology /ID# 163783
state: New Mexico
city: Lake Success
country: United States
facility: NYU Langone Rheum Assoc /ID# 159985
state: New York
city: New York
country: United States
facility: NYU Langone Medical Center /ID# 163230
state: New York
city: Potsdam
country: United States
facility: St. Lawrence Health System /ID# 159848
state: New York
city: Charlotte
country: United States
facility: American Health Research /ID# 164354
state: North Carolina
city: Charlotte
country: United States
facility: DJL Clinical Research, PLLC /ID# 161390
state: North Carolina
city: Durham
country: United States
facility: M3-Emerging Medical Research, LLC /ID# 161391
state: North Carolina
city: Greenville
country: United States
facility: Physicians East, PA /ID# 159872
state: North Carolina
city: Leland
country: United States
facility: Cape Fear Arthritis Care /ID# 161224
state: North Carolina
city: Raleigh
country: United States
facility: Shanahan Rheuma & Immuno /ID# 159987
state: North Carolina
city: Minot
country: United States
facility: Trinity Health Med Arts Clinic /ID# 159800
state: North Dakota
city: Cleveland
country: United States
facility: MetroHealth Medical Center /ID# 159888
state: Ohio
city: Columbus
country: United States
facility: The Ohio State University /ID# 159892
state: Ohio
city: Perrysburg
country: United States
facility: Clinical Research Source, Inc. /ID# 164545
state: Ohio
city: Vandalia
country: United States
facility: STAT Research, Inc. /ID# 161392
state: Ohio
city: Oklahoma City
country: United States
facility: Health Research of Oklahoma /ID# 159880
state: Oklahoma
city: Duncansville
country: United States
facility: Altoona Ctr Clinical Res /ID# 159852
state: Pennsylvania
city: Wyomissing
country: United States
facility: PA Regional Center /ID# 165670
state: Pennsylvania
city: Summerville
country: United States
facility: Articularis Healthcare Group, Inc d/b/a Low Country Rheumatology /ID# 163464
state: South Carolina
city: Jackson
country: United States
facility: West Tennessee Research Inst /ID# 159871
state: Tennessee
city: Knoxville
country: United States
facility: Rheumatology Consultants, PLLC /ID# 159796
state: Tennessee
city: Memphis
country: United States
facility: Dr. Ramesh Gupta /ID# 160061
state: Tennessee
city: Baytown
country: United States
facility: Accurate Clinical Management /ID# 159905
state: Texas
city: Beaumont
country: United States
facility: Diagnostic Group Integrated He /ID# 159794
state: Texas
city: College Station
country: United States
facility: Arth and Osteo Clin Brazo Valley /ID# 163436
state: Texas
city: Colleyville
country: United States
facility: PCCR Solution /ID# 205723
state: Texas
city: Corpus Christi
country: United States
facility: Adriana Pop-Moody MD Clinic PA /ID# 159984
state: Texas
city: Dallas
country: United States
facility: Metroplex Clinical Research /ID# 159785
state: Texas
city: Houston
country: United States
facility: Rheumatic Disease Clin Res Ctr /ID# 161240
state: Texas
city: Houston
country: United States
facility: Rheumatology Clinic of Houston /ID# 161234
state: Texas
city: Houston
country: United States
facility: "DMCR-Texas Cent for Drug Dev /ID# 164191
state: Texas
city: Lubbock
country: United States
facility: West Texas Clinical Research /ID# 205722
state: Texas
city: Lufkin
country: United States
facility: P&I Clinical Research /ID# 159826
state: Texas
city: Mesquite
country: United States
facility: SW Rheumatology Res. LLC /ID# 159993
state: Texas
city: Plano
country: United States
facility: Trinity Universal Research Association /ID# 205721
state: Texas
city: San Antonio
country: United States
facility: Arthritis & Osteo Ctr of S. TX /ID# 163784
state: Texas
city: San Marcos
country: United States
facility: Arthritis Clinic of Central TX /ID# 164049
state: Texas
city: Tomball
country: United States
facility: DM Clinical Research /ID# 161735
state: Texas
city: Waco
country: United States
facility: Arthritis & Osteoporosis Clinic /ID# 159786
state: Texas
city: Arlington
country: United States
facility: Arthritis Clinic of N. VA, P.C /ID# 159849
state: Virginia
city: Chesapeake
country: United States
facility: Ctr for Arth and Rheum Disease /ID# 159830
state: Virginia
city: Seattle
country: United States
facility: Swedish Medical Center /ID# 159890
state: Washington
city: Spokane
country: United States
facility: Arthritis Northwest, PLLC /ID# 166380
state: Washington
city: South Charleston
country: United States
facility: West Virginia Research Inst /ID# 159791
state: West Virginia
city: Franklin
country: United States
facility: Aurora Rheumatology and Immunotherapy Center /ID# 160043
state: Wisconsin
city: San Miguel de Tucuman
country: Argentina
facility: Centro Medico Privado/Reuma /ID# 159775
state: Ciuadad Autonoma De Buenos Aires
city: San Miguel de Tucuman
country: Argentina
facility: Centro Integral de Medicina Respiratoria (CIMER) /ID# 211237
state: Tucuman
city: Buenos Aires
country: Argentina
facility: Organizacion Medica de Investigacion (OMI) /ID# 160118
city: Buenos Aires
country: Argentina
facility: Hospital General de Agudos Ram /ID# 164378
city: Buenos Aires
country: Argentina
facility: Psoriahue Med Interdisciplinar /ID# 160506
city: Caba
country: Argentina
facility: Inst. de Rehab. Psicofisica /ID# 165154
city: Rosario, Santa FE
country: Argentina
facility: Instituto CAICI /ID# 160119
city: SAN Miguel DE Tucuman, Latam
country: Argentina
facility: Centro Integral de Medicina Re /ID# 160258
city: Santa Fe
country: Argentina
facility: Centro de Enfermedades del Hígado y Aparato Digestivo /ID# 165795
city: Botany
country: Australia
facility: Emeritus Research Sydney /ID# 166780
state: New South Wales
city: Woodville
country: Australia
facility: The Queen Elizabeth Hospital /ID# 169333
state: South Australia
city: Geelong
country: Australia
facility: Barwon Rheumatology /ID# 166782
state: Victoria
city: Heidelberg West
country: Australia
facility: Heidelberg Repatriation Hospital /ID# 167450
state: Victoria
city: Brest
country: Belarus
facility: Brest Regional Hospital /ID# 164535
city: Grodno
country: Belarus
facility: Healthcare Institution /ID# 164536
city: Minsk
country: Belarus
facility: First City Clinical Hospital /ID# 164534
city: Genk
country: Belgium
facility: Reuma clinic /ID# 164243
city: Banja Luka
country: Bosnia and Herzegovina
facility: University Clinical Centre of the Republic of Srpska /ID# 164503
state: Republika Srpska
city: Mostar
country: Bosnia and Herzegovina
facility: University Clinical Hospital Mostar /ID# 165799
city: Sarajevo
country: Bosnia and Herzegovina
facility: Clinical Center University of Sarajevo /ID# 164502
city: Aparecida de Goiania
country: Brazil
facility: Instituto de Ciencias Farmacêuticas /ID# 163274
state: Goias
city: Goiânia
country: Brazil
facility: CIP - Centro Internacional de Pesquisa /ID# 161821
state: Goias
city: Juiz de Fora
country: Brazil
facility: CMiP - Centro Mineiro de Pesquisa Ltda - ME /ID# 161819
state: Minas Gerais
city: Curitiba
country: Brazil
facility: EDUMED Educacao em Saude S/S L /ID# 161816
state: Parana
city: Porto Alegre
country: Brazil
facility: Instituto de Educação e Pesquisa do Hospital Moinhos de Vento /ID# 161813
state: Rio Grande Do Sul
city: Porto Alegre
country: Brazil
facility: Hospital de Clinicas de Porto Alegre /ID# 161820
state: Rio Grande Do Sul
city: Porto Alegre
country: Brazil
facility: LMK Sevicos Medicos S/S /ID# 161812
state: Rio Grande Do Sul
city: Ribeirao Preto
country: Brazil
facility: Hospital das Clinicas da Faculdade de Medicina de Ribeirão Preto - USP /ID# 163273
state: Sao Paulo
city: Santo André
country: Brazil
facility: Faculdade de Medicina do ABC /ID# 163491
state: Sao Paulo
city: Santo André
country: Brazil
facility: CEMEC - Centro Multidisciplinar de Estudos Clínicos do ABC /ID# 161810
state: Sao Paulo
city: Sao Paulo
country: Brazil
facility: CPCLIN - Centro de Pesquisas Clínicas /ID# 161818
city: Plovdiv
country: Bulgaria
facility: Department of Rheumatology, Mu /ID# 169606
city: Sofia
country: Bulgaria
facility: Excelsior Medical Center /ID# 169609
city: Sofia
country: Bulgaria
facility: Multiprofile Hospital for Active Treatment - Sofia at Military Medical Academy /ID# 169608
city: Sofia
country: Bulgaria
facility: UMHAT Sv. Ivan Rilski /ID# 202393
city: Sofia
country: Bulgaria
facility: Medical Centre Synexus Sofia /ID# 202394
city: Stara Zagora
country: Bulgaria
facility: Medical Centre Synexus Sofia, branch Stara Zagora /ID# 202524
city: Varna
country: Bulgaria
facility: Diagnostic Consultative Center /ID# 169607
city: Victoria
country: Canada
facility: Percuro Clinical Research, Ltd /ID# 157823
state: British Columbia
city: Winnipeg
country: Canada
facility: Manitoba Clinic /ID# 157829
state: Manitoba
city: Winnipeg
country: Canada
facility: Ciads /Id# 157831
state: Manitoba
city: Barrie
country: Canada
facility: The Waterside Clinic /ID# 157826
state: Ontario
city: Sainte-foy
country: Canada
facility: Groupe de Recherche en Maladies Osseuses Inc /ID# 157824
state: Quebec
city: Trois-rivières
country: Canada
facility: Ctr. de Recherche Musculo-Sque /ID# 207069
state: Quebec
city: Ñuñoa
country: Chile
facility: M y F Estudios Clínicos Ltda. /ID# 168722
state: Region Metropolitana De Santiago
city: Providencia
country: Chile
facility: CTR Estudios SpA /ID# 206217
city: Santiago
country: Chile
facility: Centro Inter Estud Clin CIEC /ID# 168725
city: Santiago
country: Chile
facility: Prosalud Ltda. /ID# 169546
city: Vitacura Santiago
country: Chile
facility: Clinica Dermacross S.A /ID# 168726
city: Bengbu
country: China
facility: 1st Aff Hosp of Bengbu Medical College /ID# 201021
state: Anhui
city: Beijing
country: China
facility: Peking University Third Hospital /ID# 201973
state: Beijing
city: Shantou
country: China
facility: The First Affiliated Hospital of Shantou University Medical College /ID# 203371
state: Guangdong
city: Zhuzhou
country: China
facility: Zhuzhou Central Hospital /ID# 200201
state: Hunan
city: Baotou
country: China
facility: The First Affiliated Hospital of Baotou Medical College, Inner Monggolia Univers /ID# 171204
state: Inner Mongolia
city: Linyi
country: China
facility: The First People's Hospital of Linyi /ID# 201970
state: Shandong
city: Shanghai
country: China
facility: Huashan Hospital of Fudan University /ID# 202191
state: Shanghai
city: Shanghai
country: China
facility: Shanghai Changhai Hospital /ID# 200202
state: Shanghai
city: Chengdu
country: China
facility: West China Hospital /ID# 200199
state: Sichuan
city: Ningbo
country: China
facility: Ningbo First Hospital /ID# 201874
state: Zhejiang
city: Huhehaote
country: China
facility: The Aff Hosp Inner Mongolia /ID# 207787
city: Kunming
country: China
facility: First Affiliated Hospital of Kunming Medical University /ID# 201264
city: Nantong
country: China
facility: Affiliated hospital of nantong university /ID# 208234
city: Soochow
country: China
facility: The First Affiliated Hospital of Soochow University /ID# 201875
city: Urumqi
country: China
facility: People's Hospital of Xinjiang /ID# 201592
city: Bogota
country: Colombia
facility: Centro de Investigacion en Reumatologia CIREEM /ID# 166030
state: Cundinamarca
city: Antioquia
country: Colombia
facility: Fundacion Centro de Investigac /Id# 168201
city: Barranquilla
country: Colombia
facility: Ctr Int de Reum del Caribe SAS /ID# 164051
city: Chia
country: Colombia
facility: Preventive Care Sas /Id# 163781
city: Medellín
country: Colombia
facility: Hospital Pablo Tobon Uribe /ID# 164233
city: Zagreb
country: Croatia
facility: Poliklinika Repromed /ID# 203555
state: Grad Zagreb
city: Rijeka
country: Croatia
facility: Klinicki bolnicki centar Rijeka /ID# 161159
state: Primorsko-goranska Zupanija
city: Zagreb
country: Croatia
facility: Medical Center Kuna-Peric /ID# 161160
city: Zagreb
country: Croatia
facility: Poliklinika Bonifarm /ID# 206662
city: Prague 4
country: Czechia
facility: Revmatologicka ambulance /ID# 159637
state: Praha 4
city: Prague 4
country: Czechia
facility: Revmatologicka ambulance /ID# 159671
state: Praha 4
city: Bruntál
country: Czechia
facility: Revmatologie Bruntal, s.r.o /ID# 159636
city: Ostrava
country: Czechia
facility: Artroscan s.r.o. /ID# 159634
city: Uherské Hradište
country: Czechia
facility: Medical Plus, s.r.o. /ID# 159635
city: Tallinn
country: Estonia
facility: Center of Clinical and Basic Research /ID# 163870
state: Harjumaa
city: Tartu
country: Estonia
facility: MediTrials /ID# 163706
state: Tartumaa
city: Tallinn
country: Estonia
facility: East Tallinn Central Hospital /ID# 163790
city: Herne
country: Germany
facility: Rheumazentrum Ruhrgebiet /ID# 163930
state: Nordrhein-Westfalen
city: Berlin-buch
country: Germany
facility: Immanuel-Krankenhaus /ID# 163931
city: Dresden
country: Germany
facility: University Clinic Carl Gustav /ID# 163926
city: Duesseldorf
country: Germany
facility: Polikilinik fuer Rheumatologie /ID# 163933
city: Frankfurt
country: Germany
facility: Cent fur Innovative Diagnostik /ID# 163927
city: Hamburg
country: Germany
facility: Hamburger Rheuma Forschungszentrum II im MVZ Rheumatologie und Autoimmunmedizin /ID# 204421
city: Rendsburg
country: Germany
facility: Dr. med. Jochen Walter FA fuer /ID# 168638
city: Tuebingen
country: Germany
facility: Med. Universitaetsklinik Inner /ID# 163929
city: Athens
country: Greece
facility: General Hospital of Athens Laiko /ID# 163476
state: Attiki
city: Athens
country: Greece
facility: General Hospital of Athens Laiko /ID# 163478
state: Attiki
city: Athens
country: Greece
facility: University General Hospital Attikon /ID# 163477
state: Attiki
city: Athens
country: Greece
facility: Naval Hospital of Athens /ID# 163486
city: Heraklion
country: Greece
facility: University General Hospital of Heraklion PA.G.N.I /ID# 163472
city: Larisa
country: Greece
facility: Reg Gen Univ Hosp Larissa /ID# 163496
city: Hong Kong
country: Hong Kong
facility: Prince of Wales Hospital /ID# 163506
city: Hong Kong
country: Hong Kong
facility: Queen Mary Hospital /ID# 162492
city: Tuen Mun
country: Hong Kong
facility: Tuen Mun Hospital /ID# 162493
city: Gyula
country: Hungary
facility: Synexus Magyarorszag Kft. - Gyula DRS /ID# 202209
state: Bekes
city: Budapest III
country: Hungary
facility: Qualiclinic Kft. /ID# 163278
state: Pest
city: Nyíregyháza
country: Hungary
facility: Szabolcs-Szatmar-Bereg Megyei Korhazak & Egyetemi Oktatok.- Klinikai Kutatasi O. /ID# 202584
state: Szabolcs-Szatmar-Bereg
city: Zalaegerszeg
country: Hungary
facility: Synexus Magyarorszag Kft. - Zalaegerszeg AS /ID# 201884
state: Zala
city: Budapest
country: Hungary
facility: Betegapolo Irgalmas Rend - Budai Irgalmasrendi Korhaz /ID# 170719
city: Budapest
country: Hungary
facility: Revita Reumatologiai Rendelo /ID# 163277
city: Budapest
country: Hungary
facility: Obudai Egeszsegugyi Centrum Kft. /ID# 163279
city: Budapest
country: Hungary
facility: Synexus Magyarorszag Kft. /ID# 203012
city: Debrecen
country: Hungary
facility: Debreceni Egyetem Kenezy Gyula /ID# 163276
city: Veszprem
country: Hungary
facility: Vital Medical Center Orvosi-es Fogaszati Kozpont /ID# 163275
city: Dublin
country: Ireland
facility: St Vincent's University Hosp /ID# 161073
city: Limerick
country: Ireland
facility: Croom Orthopaedic Hospital /ID# 164998
city: Tel Aviv-Yafo
country: Israel
facility: Tel Aviv Sourasky Medical Center /ID# 169845
state: Tel-Aviv
city: Haifa
country: Israel
facility: The Lady Davis Carmel MC /ID# 170262
city: Ramat Gan
country: Israel
facility: Sheba Medical Center /ID# 202532
city: Naples
country: Italy
facility: AOU Federico II /ID# 202411
state: Campania
city: Reggio Emilia
country: Italy
facility: Azienda Unita Sanitaria Locale/IRCCS c/o Arcispedale Santa Maria Nuova /ID# 161090
state: Emilia-Romagna
city: Rome
country: Italy
facility: Policlinico Universitario Campus Bio-Medico /ID# 162306
state: Lazio
city: Ancona
country: Italy
facility: Ospedali Riuniti Universita /ID# 161085
city: Catania
country: Italy
facility: Azienda Ospedaliera Universitaria Policlinico "G. Rodolico - San Marco" /Id# 161084
city: Nagoya-shi
country: Japan
facility: Nagoya City University Hospital /ID# 162564
state: Aichi
city: Fukuoka-shi
country: Japan
facility: Fukuoka University Hospital /ID# 162086
state: Fukuoka
city: Kitakyushu-shi
country: Japan
facility: Hospital of the University of Occupational and Environmental Health /ID# 161473
state: Fukuoka
city: Tsu-shi
country: Japan
facility: Mie University Hospital /ID# 162080
state: Mie
city: Kawachinagano-shi
country: Japan
facility: National Hospital Organization Osaka Minami Medical Center /ID# 162590
state: Osaka
city: Chuo-ku
country: Japan
facility: St.Luke's International Hospital /ID# 162016
state: Tokyo
city: Suwon-si
country: Korea, Republic of
facility: Ajou University Hospital /ID# 163891
state: Gyeonggido
city: Jung-gu
country: Korea, Republic of
facility: Inha University Hospital /ID# 163890
state: Incheon Gwang Yeogsi
city: Adazi
country: Latvia
facility: M &M Centrs /Id# 161483
city: Liepaja
country: Latvia
facility: D.Saulites-Kandevicas PP in Cardiology and Rheumatology /ID# 161488
city: Riga
country: Latvia
facility: Clinic ORTO /ID# 161486
city: Riga
country: Latvia
facility: P. Stradins Clinical Univ Hosp /ID# 164442
city: Kaunas
country: Lithuania
facility: VAKK dr. Kildos Clinic /ID# 167257
city: Klaipeda
country: Lithuania
facility: Klaipeda University Hospital /ID# 167258
city: Siauliai
country: Lithuania
facility: Public Institution Republican /ID# 165155
city: Vilnius
country: Lithuania
facility: Vilnius University Hospital /ID# 165123
city: Ipoh
country: Malaysia
facility: Hospital Raja Permaisuri Bainun /ID# 161099
state: Perak
city: Seremban
country: Malaysia
facility: Hospital Tuanku Ja afar /ID# 161096
city: Mexico City
country: Mexico
facility: CINTRE, Centro de Investigación y Tratamiento Reumatológico SC /ID# 164006
state: Ciudad De Mexico
city: Guadalajara
country: Mexico
facility: Instituto Jalisciense de Metabolismo SC /ID# 164005
state: Jalisco
city: Chihuahua
country: Mexico
facility: Invest y Biomed de Chihuahua /ID# 164007
city: Leeuwarden
country: Netherlands
facility: Medisch Centrum Leeuwarden /ID# 161575
city: Rotterdam
country: Netherlands
facility: Erasmus Medisch Centrum /ID# 161092
city: Rotterdam
country: Netherlands
facility: Maasstad Ziekenhuis /ID# 160168
city: Hamilton
country: New Zealand
facility: Waikato Hospital /ID# 166415
state: Waikato
city: Auckland
country: New Zealand
facility: North Shore Hospital /ID# 169409
city: Auckland
country: New Zealand
facility: Middlemore Hospital /ID# 166414
city: Nelson
country: New Zealand
facility: Porter Rheumatology Ltd /ID# 200421
city: Timaru
country: New Zealand
facility: Timaru Rheumatology Studies /ID# 166413
city: Forde
country: Norway
facility: Helse Forde /ID# 167853
state: Sogn Og Fjordane
city: Trondheim
country: Norway
facility: St. Olavs Hospital HF /ID# 163321
state: Sor-Trondelag
city: Wrocław
country: Poland
facility: Synexus Polska Sp. z o.o. /ID# 204506
state: Dolnoslaskie
city: Toruń
country: Poland
facility: NZOZ Nasz Lekarz /ID# 163774
state: Kujawsko-pomorskie
city: Lodz
country: Poland
facility: Salve Medica Sp. z o.o. S.K. /ID# 206300
state: Lodzkie
city: Cracow
country: Poland
facility: Malopolskie Centrum Kliniczne /ID# 163777
state: Malopolskie
city: Gdańsk
country: Poland
facility: Synexus Polska Sp. z o.o. Oddzial w Gdansku /ID# 206299
state: Pomorskie
city: Gdynia
country: Poland
facility: Synexus Polska Sp. z o.o. Oddzial w Gdyni /ID# 207157
state: Pomorskie
city: Katowice
country: Poland
facility: Synexus Polska Sp. z o.o. Oddzial Katowice /ID# 204510
state: Slaskie
city: Olsztyn
country: Poland
facility: ETYKA-Osrodek Badan Klinicznyc /ID# 163776
state: Warminsko-mazurskie
city: Elblag
country: Poland
facility: Centrum Kliniczno-Badawcze /ID# 161830
city: Krakow
country: Poland
facility: Krakowskie Centrum Medyczne /ID# 206302
city: Poznan
country: Poland
facility: Synexus Polska Sp. z o.o. Oddzial w Poznaniu /ID# 207158
city: Warsaw
country: Poland
facility: Medycyna Kliniczna /ID# 166288
city: Warsaw
country: Poland
facility: Synexus Polska Sp. z.o.o. /ID# 203987
city: Warsaw
country: Poland
facility: Reumatika - Centrum Reumatologii NZOZ /ID# 161831
city: Lisbon
country: Portugal
facility: Instituto Portugues De Reumatologia /ID# 165858
state: Lisboa
city: Lisbon
country: Portugal
facility: Centro Hospitalar Lisboa Ocidental, EPE /ID# 165861
state: Lisboa
city: Vila Nova De Gaia
country: Portugal
facility: Centro Hospitalar de Vila Nova Gaia/Espinho, EPE /ID# 165862
state: Porto
city: Lisboa
country: Portugal
facility: Centro Hospitalar Lisboa Norte, EPE /ID# 165860
city: Lisbon
country: Portugal
facility: Hospital CUF Descobertas /ID# 165866
city: Loures
country: Portugal
facility: Hospital Beatriz Angelo /ID# 165865
city: Viana Do Castelo
country: Portugal
facility: Unidade Local De Saude Do Alto Minho /ID# 165863
city: Carolina
country: Puerto Rico
facility: Cruz-Santana, Carolina, PR /ID# 163307
city: Ponce
country: Puerto Rico
facility: Ponce Medical School Foundation /ID# 163920
city: San Juan
country: Puerto Rico
facility: GCM Medical Group, PSC /ID# 162160
city: Korolev
country: Russian Federation
facility: Family Outpatient clinic#4 LLC /ID# 164530
state: Moskva
city: Novosibirsk
country: Russian Federation
facility: LLC Medical Center /ID# 164529
state: Novosibirskaya Oblast
city: Kazan
country: Russian Federation
facility: Kazan State Medical University /ID# 164531
state: Tatarstan, Respublika
city: Moscow
country: Russian Federation
facility: Moscow S.P.Botkin City Clinica /ID# 164533
city: St. Petersburg
country: Russian Federation
facility: State budgetary institution /ID# 164532
city: Belgrade
country: Serbia
facility: Institute for Rheumatology /ID# 166217
state: Beograd
city: Belgrade
country: Serbia
facility: Institute for Rheumatology /ID# 166223
state: Beograd
city: Belgrade
country: Serbia
facility: Institute for Rheumatology /ID# 166229
state: Beograd
city: Belgrade
country: Serbia
facility: Institute for Rheumatology /ID# 166231
state: Beograd
city: Belgrade
country: Serbia
facility: Military Medical Academy /ID# 166293
state: Beograd
city: Singapore
country: Singapore
facility: Singapore General Hospital /ID# 161094
state: Central Singapore
city: Singapore
country: Singapore
facility: Tan Tock Seng Hospital /ID# 161095
city: Martin
country: Slovakia
facility: MEDMAN s.r.o. /ID# 165892
city: Nové Mesto Nad Váhom
country: Slovakia
facility: Reumatologická ambulancia Reum.hapi s.r.o. /ID# 166486
city: Pieštany
country: Slovakia
facility: Slovak research center Team Member, Thermium s.r.o. /ID# 166489
city: Ljubljana
country: Slovenia
facility: Univ Medical Ctr Ljubljana /ID# 164212
city: Maribor
country: Slovenia
facility: University Medical Ctr Maribor /ID# 169260
city: Murska Sobota
country: Slovenia
facility: General Hospital Murska Sobota /ID# 164211
city: Port Elizabeth
country: South Africa
facility: Greenacres Hospital /ID# 164190
state: Eastern Cape
city: Johannesburg
country: South Africa
facility: Wits Clinical Research Site /ID# 163919
state: Gauteng
city: Pretoria
country: South Africa
facility: University of Pretoria /ID# 163852
state: Gauteng
city: Pretoria
country: South Africa
facility: Jakaranda Hospital /ID# 164242
state: Gauteng
city: Cape Town
country: South Africa
facility: Arthritis Clinical Research Tr /ID# 163855
state: Western Cape
city: Stellenbosch
country: South Africa
facility: Winelands Medical Research Ctr /ID# 163853
state: Western Cape
city: A Coruña
country: Spain
facility: Hospital Universitario A Coruña - CHUAC /ID# 161129
state: A Coruna
city: Granada
country: Spain
facility: Hospital Campus de la Salud /ID# 170760
city: Madrid
country: Spain
facility: Hospital Universitario Ramon y Cajal /ID# 161130
city: Madrid
country: Spain
facility: Hospital Universitario 12 de Octubre /ID# 163198
city: St. Gallen
country: Switzerland
facility: Kantonsspital St. Gallen /ID# 158131
state: Sankt Gallen
city: Fribourg
country: Switzerland
facility: HFR Fribourg - Hopital Canton /ID# 162090
city: Taichung City
country: Taiwan
facility: China Medical University Hosp /ID# 159402
state: Taichung
city: Taichung
country: Taiwan
facility: Chung Shan Medical University /ID# 159403
city: Taipei City
country: Taiwan
facility: National Taiwan University Hospital /ID# 160878
city: Taipei City
country: Taiwan
facility: Taipei Veterans General Hosp /ID# 166222
city: Taoyuan City
country: Taiwan
facility: Linkou Chang Gung Memorial Ho /ID# 166221
city: Saricam Adana
country: Turkey
facility: Cukurova Universitesi Tip Fakultesi /ID# 162516
state: Adana
city: Sihhiye
country: Turkey
facility: Hacettepe Universitesi Tip Fak /ID# 162518
state: Ankara
city: Istanbul
country: Turkey
facility: Bakirkoy Dr. Sadi Konuk Training & Research Hospital /ID# 162517
city: Istanbul
country: Turkey
facility: Marmara Universitesi Pendik Egitim ve Arastirma Hastanesi /ID# 163383
city: Meram Konya
country: Turkey
facility: Necmettin Erbakan Universitesi /ID# 163382
city: Sakarya
country: Turkey
facility: Sakarya Universitesi Egitim /ID# 163397
city: Kharkiv
country: Ukraine
facility: State Institution L. T. Malaya Therapy National Institution of NAMS of Ukraine /ID# 164170
state: Kharkivska Oblast
city: Lviv
country: Ukraine
facility: Lviv Regional Clinical Hospita /ID# 164178
state: Lvivska Oblast
city: Kharkiv
country: Ukraine
facility: Kharkiv Regional Council Regional Clinical Hospital /ID# 210189
city: Kiev
country: Ukraine
facility: NSC Strazhesko Ist Cardiology /ID# 164043
city: Kyiv
country: Ukraine
facility: Med Ctr of Private High Ed Ins /ID# 208527
city: Kyiv
country: Ukraine
facility: Medical Center of LLC Medbud-Clinic /ID# 208528
city: Kyiv
country: Ukraine
facility: Kyiv Railway Clinical Hosp No.2 /ID# 208951
city: Kyiv
country: Ukraine
facility: LLC Revmocentr /ID# 164177
city: Kyiv
country: Ukraine
facility: MNI KRC Kyiv Regional Clinical Hospital /ID# 210188
city: Odesa
country: Ukraine
facility: Odessa National Medical Univ /ID# 164244
city: Vinnytsia
country: Ukraine
facility: Vinnytsia Regional Clinical Hospital n.a. M.I.Pyrogov /ID# 164245
city: London
country: United Kingdom
facility: Whipps Cross Univ Hospital /ID# 161055
state: London, City Of
city: London
country: United Kingdom
facility: Guy's and St Thomas' NHS Found /ID# 161065
state: London, City Of
city: Christchurch
country: United Kingdom
facility: Christchurch Hospital /ID# 162702
city: Coventry
country: United Kingdom
facility: UH Coventry & Warwickshire /ID# 162701
city: Glasgow
country: United Kingdom
facility: Glasgow Royal Infirmary /ID# 162703
city: Luton
country: United Kingdom
facility: Luton & Dunstable University Hospital /ID# 162704
Study officials:
affiliation: AbbVie
name: AbbVie Inc.
role: STUDY_DIRECTOR
References:
citation: McInnes IB, Kato K, Magrey M, Merola JF, Kishimoto M, Haaland D, Chen L, Duan Y, Liu J, Lippe R, Wung P. Efficacy and Safety of Upadacitinib in Patients with Psoriatic Arthritis: 2-Year Results from the Phase 3 SELECT-PsA 1 Study. Rheumatol Ther. 2023 Feb;10(1):275-292. doi: 10.1007/s40744-022-00499-w. Epub 2022 Oct 15.
citation: Mease P, Kavanaugh A, Gladman D, FitzGerald O, Soriano ER, Nash P, Feng D, Lertratanakul A, Douglas K, Lippe R, Gossec L. Disease Control with Upadacitinib in Patients with Psoriatic Arthritis: A Post Hoc Analysis of the Randomized, Placebo-Controlled SELECT-PsA 1 and 2 Phase 3 Trials. Rheumatol Ther. 2022 Aug;9(4):1181-1191. doi: 10.1007/s40744-022-00449-6. Epub 2022 May 23.
citation: Burmester GR, Winthrop K, Blanco R, Nash P, Goupille P, Azevedo VF, Salvarani C, Rubbert-Roth A, Lesser E, Lippe R, Lertratanakul A, Mccaskill RM, Liu J, Ruderman EM. Safety Profile of Upadacitinib up to 3 Years in Psoriatic Arthritis: An Integrated Analysis of Two Pivotal Phase 3 Trials. Rheumatol Ther. 2022 Apr;9(2):521-539. doi: 10.1007/s40744-021-00410-z. Epub 2021 Dec 30.
citation: Nash P, Richette P, Gossec L, Marchesoni A, Ritchlin C, Kato K, McDearmon-Blondell EL, Lesser E, McCaskill R, Feng D, Anderson JK, Ruderman EM. Upadacitinib as monotherapy and in combination with non-biologic disease-modifying antirheumatic drugs for psoriatic arthritis. Rheumatology (Oxford). 2022 Aug 3;61(8):3257-3268. doi: 10.1093/rheumatology/keab905.
citation: Strand V, Mease PJ, Soriano ER, Kishimoto M, Salvarani C, Saffore CD, Zueger P, McDearmon-Blondell E, Kato K, Gladman DD. Improvement in Patient-Reported Outcomes in Patients with Psoriatic Arthritis Treated with Upadacitinib Versus Placebo or Adalimumab: Results from SELECT-PsA 1. Rheumatol Ther. 2021 Dec;8(4):1789-1808. doi: 10.1007/s40744-021-00379-9. Epub 2021 Oct 12.
citation: Muensterman E, Engelhardt B, Gopalakrishnan S, Anderson JK, Mohamed MF. Upadacitinib pharmacokinetics and exposure-response analyses of efficacy and safety in psoriatic arthritis patients - Analyses of phase III clinical trials. Clin Transl Sci. 2022 Jan;15(1):267-278. doi: 10.1111/cts.13146. Epub 2021 Oct 27.
citation: McInnes IB, Anderson JK, Magrey M, Merola JF, Liu Y, Kishimoto M, Jeka S, Pacheco-Tena C, Wang X, Chen L, Zueger P, Liu J, Pangan AL, Behrens F. Trial of Upadacitinib and Adalimumab for Psoriatic Arthritis. N Engl J Med. 2021 Apr 1;384(13):1227-1239. doi: 10.1056/NEJMoa2022516.