Clinical trial NCT00144885: IMAGE-Endocarditis: Resonance Magnetic Imaging at the Acute Phase of Endocarditis
Official title: Resonance Magnetic Imaging at the Acute Phase of Endocarditis: Diagnostic and Therapeutic Impact
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Endocarditis, Bacterial
Keywords: Endocarditis
RMI
Impact measure
Lead sponsor: Assistance Publique - Hôpitaux de Paris
Sponsor class: OTHER
First posted: 2005-09-05
Enrollment: 150
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NON_RANDOMIZED
Intervention model: SINGLE_GROUP

Brief summary: Patients with definite or possible infective endocarditis are included in this protocol, at the acute phase of the disease.

Detailed description: Patients with definite or possible infective endocarditis are included in this protocol, at the acute phase of the disease.

Resonance magnetic imaging (head and abdomen) will be performed systematically before Day 7.

The impact on the diagnosis and therapeutic options will be assessed, as compared to pre resonance magnetic nuclear (RMN) imaging declaration.

Eligibility criteria: Inclusion Criteria:

* Acute phase of infective endocarditis

Exclusion Criteria:

* Contra indication to RMN

Primary outcomes:
measure: Modification of therapeutic project
timeFrame: As soon as RMI is performed
Secondary outcomes:
measure: Modification of diagnostic classification (Duke modified criteria)
timeFrame: As soon as RMI is performed
Other outcomes:
Locations:
city: Paris
country: France
facility: Hôpital Bichat Claude Bernard, 46 rue Henri Huchard
Study officials:
affiliation: Hôpital Bichat, Assistance Publique Hôpitaux de Paris
name: Xavier Duval
role: PRINCIPAL_INVESTIGATOR
References:
citation: Mahr A, Batteux F, Tubiana S, Goulvestre C, Wolff M, Papo T, Vrtovsnik F, Klein I, Iung B, Duval X; IMAGE Study Group. Brief report: prevalence of antineutrophil cytoplasmic antibodies in infective endocarditis. Arthritis Rheumatol. 2014 Jun;66(6):1672-7. doi: 10.1002/art.38389.
citation: Iung B, Tubiana S, Klein I, Messika-Zeitoun D, Brochet E, Lepage L, Al-Attar N, Ruimy R, Leport C, Wolff M, Duval X; ECHO-IMAGE Study Group. Determinants of cerebral lesions in endocarditis on systematic cerebral magnetic resonance imaging: a prospective study. Stroke. 2013 Nov;44(11):3056-62. doi: 10.1161/STROKEAHA.113.001470. Epub 2013 Sep 3.
citation: Iung B, Klein I, Mourvillier B, Olivot JM, Detaint D, Longuet P, Ruimy R, Fourchy D, Laurichesse JJ, Laissy JP, Escoubet B, Duval X; Study Group. Respective effects of early cerebral and abdominal magnetic resonance imaging on clinical decisions in infective endocarditis. Eur Heart J Cardiovasc Imaging. 2012 Aug;13(8):703-10. doi: 10.1093/ehjci/jes023. Epub 2012 Feb 14.
citation: Duval X, Iung B, Klein I, Brochet E, Thabut G, Arnoult F, Lepage L, Laissy JP, Wolff M, Leport C; IMAGE (Resonance Magnetic Imaging at the Acute Phase of Endocarditis) Study Group. Effect of early cerebral magnetic resonance imaging on clinical decisions in infective endocarditis: a prospective study. Ann Intern Med. 2010 Apr 20;152(8):497-504, W175. doi: 10.7326/0003-4819-152-8-201004200-00006.