Clinical trial NCT02333734: Investigation of the Effect of 8-week Controlled High Intense Interval Training in Type 2 Diabetic Patients
Official title: Investigation of the Effect of 8-week Controlled High Intense Interval Training in Type 2 Diabetic Patients
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Type 2 Diabetes
Keywords: Type 2 diabetes
Interval training
Insulin resistance
fat metabolism
Lead sponsor: Aarhus University Hospital
Sponsor class: OTHER
First posted: 2015-01-07
Enrollment: 23
Sex: ALL
Minimum age (years): 40
Maximum age (years): 65
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: BASIC_SCIENCE

Brief summary: The overall objective of this study is to examine the blood flow in the thigh muscles and sugar metabolism before and after 8 weeks of high intensity interval training (HIIT) on a bicycle ergometer in patients with type 2 diabetes (T2D) and matched controls. The following parameters are included in the assessment:

* Sugar Metabolism
* Muscle and fat mass
* The blood flow at rest around the thigh muscles
* Oxygen uptake test on a bicycle ergometer and 5 km time trial

Detailed description: Type 2 diabetes (T2D) can be defined as a bihormonal metabolic disorder characterised by insufficient insulin secretion and abnormal glucagon secretion. It is however well established that physical activity per se improves glucose and may postpone or even slow down in the diabetic population. Glycaemic control may be improved more by high intensity interval training than by intensities from existing recommended guidelines. Additionally, there seems to be accumulating evidence that high intensity interval training induces increased overall fat and abdominal fat mass loss as opposed to traditional continuous endurance training Therefore we hypothesise that 3 weekly sessions of high intensity interval training (10×60 sec. at an intensity inducing 90% of maximal heart frequency with a recovery of 60 sec. between each bout) over 8 weeks improves overall glycaemic control (glucose, insulin and glucagon), inflammatory status (interleukins, cytokines, chemokines and cell adhesion molecules) and blood flow (NO and PGI2 vasodilatory capabilities).

Eligibility criteria: Inclusion Criteria:

* Type 2 diabetes or matched healthy controls. T2D subject only : HbA1c \> 7,3. All subjects have an age between 40-65 years and a body mass index between 25-40 kg/m2. Both genders is allowed

Exclusion Criteria:

* Severe diseases /immobility

Primary outcomes:
measure: Oral Glucose tolerance test (OGTT)
timeFrame: baseline and 8 weeks
Secondary outcomes:
measure: Physical fitness
timeFrame: baseline and 8 weeks
Other outcomes:
measure: Muscle and fat mass
timeFrame: baseline and 8 weeks
measure: blood flow
timeFrame: baseline and 8 weeks
Locations:
city: Aarhus C
country: Denmark
facility: Aarhus Universityhospital, Aarhus University
Study officials:
References:
citation: Madsen SM, Thorup AC, Overgaard K, Jeppesen PB. High Intensity Interval Training Improves Glycaemic Control and Pancreatic beta Cell Function of Type 2 Diabetes Patients. PLoS One. 2015 Aug 10;10(8):e0133286. doi: 10.1371/journal.pone.0133286. eCollection 2015.