Clinical trial NCT06606639: Reproducibility of Acute Caffeine Effect
Official title: Reproducibility of the Acute Effect of Caffeine on Energy Metabolism and Muscular Strength, Power and Endurance Performance
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Caffeine and Resistance Exercise
Lead sponsor: University of Alcala
Sponsor class: OTHER
First posted: 2024-09-23
Enrollment: 48
Sex: ALL
Minimum age (years): 18
Maximum age (years): 35
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: CROSSOVER
Primary purpose: OTHER

Brief summary: Introduction: Various studies have evaluated and verified the ergogenic effect of acute caffeine intake on sports performance, specifically on strength and power performance. However, all experimental investigations designed so far have been based on the comparison of the \&#34;caffeine\&#34; and \&#34;placebo\&#34; conditions in a single trial, not considering the reproducibility and variability of caffeine in multiple trials.

Objectives: The present study aims to evaluate the reproducibility and replicability of the acute effect of caffeine intake on energy metabolism and the muscular production of force, power and endurance, according to sex (men vs women) and type of exercise ( bench press vs squat).


Eligibility criteria: Inclusion Criteria:

* Age between ≥ 18 and ≤ 35 years.
* Body Mass Index (BMI) \&amp;lt; 25 kg/m².
* Resistance-trained individuals (\&amp;gt; 2 years of structured trained).
* Healthy men and women without neurological, cardiometabolic, immunological, or physical conditions that prevent them from exercising.
* Participants must be able to perform the tests described in the following section.

Exclusion Criteria:

* History of neuromuscular diseases, heart diseases, or diseases that may affect liver or muscle metabolism.
* Use of drugs, other stimulants or sport supplements that interfere with the the study dietary supplement.
* Sedentary habits (\&amp;lt;150 min/week of moderate exercise).
* Having undergone prolonged periods of forced physical inactivity during the 6 months prior to the study.
* Performing strenuous exercise during the 48 hours prior to the tests.
* Failure to replicate the same food intake on the two days of the experiments.
* Consuming caffeine or any other stimulant after 6 pm the day before the training or tests, to avoid headaches, discomfort, or lethargy among regular caffeine consumers.

Primary outcomes:
measure: Mean velocity at different %1RM
timeFrame: Through study completion, an average of 4 weeks
measure: Peak velocity at different %1RM
timeFrame: Through study completion, an average of 4 weeks
measure: Mean power output at different %1RM
timeFrame: Through study completion, an average of 4 weeks
measure: Peak power output and time to reach peak power output at different %1RM
timeFrame: Through study completion, an average of 4 weeks
measure: Number of repetitions performed in 1 set at 65%1RM until task failure
timeFrame: Through study completion, an average of 4 weeks
measure: Bar velocity deplacement performed in 1 set at 65%1RM until task failure
timeFrame: Through study completion, an average of 4 weeks
measure: Power output generated in 1 set at 65%1RM until task failure
timeFrame: Through study completion, an average of 4 weeks
measure: Resting Metabolic Rate (RMR)
timeFrame: Through study completion, an average of 4 weeks
measure: Maximal Fat Oxidation Rate (MFO)
timeFrame: Through study completion, an average of 4 weeks
Secondary outcomes:
measure: Physical activity (METs-min/wk)
timeFrame: Through study completion, an average of 4 weeks
measure: Dietary (g/kg of macronutrients)
timeFrame: Through study completion, an average of 4 weeks
measure: Mood state
timeFrame: Through study completion, an average of 4 weeks
measure: Adverse effects
timeFrame: Through study completion, an average of 4 weeks
measure: Fat mass
timeFrame: Through study completion, an average of 4 weeks
measure: Fat-free mass
timeFrame: Through study completion, an average of 4 weeks
Other outcomes:
Locations:
city: Alcalá de Henares
country: Spain
facility: Facultad de Medicina y Ciencias de la Salud. Universidad de Alcalá
state: Madrid
Study officials:
References: