Clinical trial NCT05816434: More Sleep: Pain Response to Longer Sleep
Official title: Can More Sleep Improve Pain Responses, Symptomatology, and Regulation in College Students?
Study type: INTERVENTIONAL
Overall status: RECRUITING
Phase: NA
Conditions: Sleep
Pain
Lead sponsor: Penn State University
Sponsor class: OTHER
First posted: 2023-04-18
Enrollment: 45
Sex: ALL
Minimum age (years): 18
Maximum age (years): 24
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: PREVENTION

Brief summary: This study is being done to find out whether extending sleep for at least an hour per night, seven days a week, predicts a higher tolerance and a higher threshold for pain. This is a 21-day study. Participants will be asked to wear sleep- and heart- monitoring watches. Pressure pain and cold pain will be measured at study visits.


Eligibility criteria: Inclusion Criteria:

1. 18 to 24 (inclusive) years of age at enrollment
2. Fluent English speaker and reader
3. Willing to refrain from initiating new therapeutic interventions (e.g., medication; behavioral) designed to target sleep or pain for the duration of study participation

Exclusion Criteria:

1. Diagnosed with a sleep disorder
2. Diagnosed with a pain disorder
3. Has experienced a cold-related injury frostbite or has any other nerve damage to the feet
4. Has a history of injury to any of the muscular measurement sites for pain (I.e. shoulder, jaw, forearm)
5. Diagnosed with hypertension or cardiovascular disease
6. Evidence of hypertension
7. Diagnosed serious mental health disorder or substance use disorder
8. Taking any physician-directed pharmacologic intervention for sleep
9. Taking any physician-directed pharmacologic intervention for pain
10. Personal health history of traumatic brain injury
11. Pregnant
12. Current smoker

Primary outcomes:
measure: Change in pressure pain threshold from before to after sleep extension
timeFrame: Momentary at study visit 2 (at the end of week1) and a week later at study visit 3 (at the end of week2).
measure: Change in pressure pain tolerance from before to after sleep extension
timeFrame: Momentary at study visit 2 (at the end of week1) and a week later at study visit 3 (at the end of week2).
measure: Change in weekly average of momentary pain self-reports from before to after sleep extension
timeFrame: (averaged) Daily surveys during study week 1 (pre-intervention) and study week 2 (intervention)
measure: Change in thermal pain threshold from before to after sleep extension
timeFrame: Momentary at study visit 2 (at the end of week1) and a week later at study visit 3 (at the end of week2).
measure: Change in thermal pain tolerance from before to after sleep extension
timeFrame: Momentary at study visit 2 (at the end of week1) and a week later at study visit 3 (at the end of week2).
measure: Change in pain inhibition from before to after sleep extension
timeFrame: Momentary at study visit 2 (at the end of week1) and a week later at study visit 3 (at the end of week2).
Secondary outcomes:
Other outcomes:
Locations:
city: University Park
country: United States
facility: Pennsylvania State University
state: Pennsylvania
Study officials:
References: