Clinical trial NCT05214534: Contribution of SuPAR for Patients in a Situation of Uncertainty Downstream of Emergencies
Official title: Contribution of SuPAR for Patients in a Situation of Uncertainty Downstream of Emergencies
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Emergencies
Disease
In-hospital Observation
Keywords: Supar
Patient triage
Emergency
Lead sponsor: University Hospital, Clermont-Ferrand
Sponsor class: OTHER
First posted: 2022-01-28
Enrollment: 202
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: RETROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: all patients requiring clinical observation for a final referral decision and meeting the eligibility criteria will be offered the study

Brief summary: In this study, the investigators will investigate the relationship between the blood level of SuPAR at admission to the emergency department of the Clermont-Ferrand University Hospital, and the outcome of patients after their hospitalization in a short stay unit.

Detailed description: SuPAR (Soluble urokinase Plasminogen Activator Receptor) is a non-specific prognostic blood biomarker related to inflammation. An elevated SuPAR value reflects significant chronic inflammation and predicts a risk of negative outcome and even short-term mortality (intra-hospital, 30 days, 90 days). Conversely, a low SuPAR value is a strong indicator of good prognosis and low risk of readmission. It is therefore of interest to know a patient's SuPAR blood level to enable the clinician to decide whether the patient should be admitted or discharged. SuPAR has been shown to be the best prognostic marker associated with the presence and progression of disease and risk of mortality. The use of SuPAR in clinical routine adds significant complementary information to the standard Early Warning Score assessment and to the classical parameters such as CRP, PCT, Lactate, ALT, Bilirubin, and CBC in the pre-admission of acute patients.

Patients admitted to the emergency department will receive their usual management. We will test the added value of the SuPAR assay in the prognosis of patients' outcome at discharge.

Eligibility criteria: Inclusion Criteria:

* Patient, male or female, over 18 years old
* Admitted to the emergency department of the Clermont-Ferrand University Hospital for a medical reason,
* Classified as FRENCH II or III by the nurse organizer of the reception management
* Necessity of clinical observation in the Short Term Hospitalization Unit for final orientation decision
* Requires a blood test upon arrival in the emergency department
* Able to give informed non-opposition to participate in the research.
* Affiliation to a Social Security system

Exclusion Criteria:

* Patient under guardianship or curatorship
* Pregnant and breast feeding woman
* Patient admitted for psychiatric pathology
* Patient with a limitation of therapeutics
* Refusal to participate
* Patient hospitalized because of a particular social context

Primary outcomes:
measure: Relationship between blood supar levels and patient outcome at discharge
timeFrame: When the excepted 150 patients will be included, estimated 6 months
Secondary outcomes:
measure: National Early Warning Score 2 (NEWS2)
timeFrame: Hour 0
measure: Modified Early Warning Score (MEWS)
timeFrame: Hour 0
measure: Blood supar levels
timeFrame: When the excepted 150 patients will be included, estimated 6 months
measure: Blood CRP value
timeFrame: Hour 0
measure: Cardiac frequency
timeFrame: Hour 0
measure: Respiratory rate
timeFrame: Hour 0
measure: Temperature
timeFrame: Hour 0
measure: Systolic blood pressure
timeFrame: Hour 0
measure: Diastolic blood pressure
timeFrame: Hour 0
measure: French triage
timeFrame: Hour 0
measure: Main diagnosis retained by the physician
timeFrame: at the end of hospitalization
Other outcomes:
Locations:
city: Clermont-Ferrand
country: France
facility: CHU clermont-ferrand
Study officials:
affiliation: University Hospital, Clermont-Ferrand
name: Farès Moustafa
role: PRINCIPAL_INVESTIGATOR
References: