Clinical trial NCT00803517: Comparison of Multifocal Electroretinogram Assessment in Chronic Central Serous Chorioretinopathy (CSC) Between Laser Treatment Group and Photodynamic Therapy Group in Chronic Central Serous Chorioretinopathy
Official title: Comparison of Multifocal Electroretinogram Assessment Between Laser Treatment Group and Photodynamic Therapy Group in Chronic Central Serous Chorioretinopathy
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Central Serous Chorioretinopathy
Keywords: chronic central serous chorioretinopathy
multifocal electroretinogram
central retinal function after treatment in chronic serous chorioretinopathy
Lead sponsor: Samsung Medical Center
Sponsor class: OTHER
First posted: 2008-12-05
Enrollment: 24
Sex: ALL
Minimum age (years): 20
Maximum age (years): 80
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: CASE_CONTROL
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: 1. Laser Group: extrafoveal focal leakage on FAG
2. photodynamic therapy Group: no definite focal leak on FAG subfoveal or juxtafoveal focal leakage on FAG, or s-RPED involving foveal center

Brief summary: This study is a comparison of multifocal electroretinogram assessment between the laser treatment group and the photodynamic therapy group in chronic central serous chorioretinopathy.

Detailed description: 1. Laser Group: extrafoveal focal leakage on FAG
2. PDT Group: no definite focal leak on FAG subfoveal or juxtafoveal focal leakage on FAG, or serous retinal pigmentary epithelial detachment involving foveal center

Inclusion criteria

1. Chronic serous chorioretinopathy (over 3 months) when subretinal fluid persisted in the subfoveal region demonstrated by clinical examination and OCT
2. Ability to maintain steady fixation for mfERG
3. Presence of abnormal dilated choroidal vasculature in ICGA
4. Symptom duration over 3 months

Exclusion criteria

1. previous PDT or laser treatment history
2. evidence of Choriinal neovascularization in FAG
3. other chorioretinal disorders that can cause macular exudation such as age-related macular degeneration, pathologic myopia, angioid streaks, trauma, inflammatory diseases, retinal vasculopathies, and hereditary dystrophies

follow-up Visit

1)baseline 2)1month 3)3months 4)6 months

each visit: multifocal electroretinogram, visual acuity, optical coference timography should be measured.

Eligibility criteria: Inclusion Criteria:

1. CSC (over 3 months) when subretinal fluid persisted in the subfoveal region demonstrated by clinical examination and OCT
2. Ability to maintain steady fixation for mfERG
3. Presence of abnormal dilated choroidal vasculature in ICGA
4. Symptom duration over 3 months

Exclusion Criteria:

1. Previous PDT or laser treatment history
2. Evidence of CNV in FAG
3. Other chorioretinal disorders that can cause macular exudation such as age-related macular degeneration, pathologic myopia, angioid streaks, trauma, inflammatory diseases, retinal vasculopathies, and hereditary dystrophies

Primary outcomes:
measure: Multifocal Electroretinogram Amplitudes
timeFrame: baseline, 1 month, 3 months, 6 months
Secondary outcomes:
measure: Best Corrected Visual Acuity
timeFrame: baseline, 1 month, 3 months, 6 months
Other outcomes:
Locations:
city: Seoul
country: Korea, Republic of
facility: Samsung Medical Center
Study officials:
affiliation: Samsung Medical Center
name: Se Woong Kang, MD
role: STUDY_CHAIR
References: