Clinical trial NCT02556931: Shorter Course Tacro After NMA, Related Donor PBSCT With High-dose Posttransplant Cy for Hard-to-Engraft Malignancies
Official title: Phase II Study of Shortened-duration Tacrolimus Following Nonmyeloablative Peripheral Blood Stem Cell Transplant With High-dose Posttransplantation Cyclophosphamide in Malignancies That Are Challenging to Engraft
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE2
Conditions: Myelodysplastic Syndrome
Chronic Myelomonocytic Leukemia
Small Lymphocytic Lymphoma
Chronic Lymphocytic Leukemia
Prolymphocytic Leukemia
Chronic Myeloid Leukemia
Chronic Myeloproliferative Disorders
Multiple Myeloma
Plasma Cell Neoplasm
Plasma Cell Dyscrasia
Myelofibrosis
Polycythemia Vera
Essential Thrombocythemia
Plasma Cell Leukemia
Keywords: immunosuppression
nonmyeloablative
non-myeloablative
allogeneic
tacrolimus
peripheral blood
cyclophosphamide
mycophenolate mofetil
Lead sponsor: Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
Sponsor class: OTHER
Collaborators: name: National Cancer Institute (NCI)
First posted: 2015-09-22
Enrollment: 117
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NON_RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: To see if it is possible to use short-duration tacrolimus after a peripheral blood stem cell transplant in certain malignancies that are considered difficult to engraft.

Detailed description: The main goal is to learn whether a drug called tacrolimus, which is an immune-lowering drug (an immunosuppressant) given after transplant to help prevent certain complications, can be given safely for a shorter period of time than it has been in the past. The experiences with immunosuppression duration with other allogeneic HSCT platforms cannot be directly extrapolated to the high-dose posttransplantation cyclophosphamide platform (another type of immunosuppressant given after transplant to help prevent GVHD). There are presently no published data on the minimum required duration of tacrolimus after nonmyeloablative HSCT that includes high-dose Cy as part of postgrafting immunosuppression. The effectiveness of high-dose posttransplantation Cy in GVHD prevention, however, permits the investigation of this question. At the present time there are few or no cures for diseases studied on this trial outside of a bone marrow or peripheral blood transplant. The peripheral blood for this transplant comes from a relative who is a half-match or "haplo" match to the participant. Possible donors include parents, siblings, and children. In order to help the bone marrow grow, or "take", inside the body, participants will receive chemotherapy and radiation before the transplant. After the transplant participants will receive high doses of cyclophosphamide (Cytoxan®) along with other medications to lower the immune system, such as tacrolimus. These medications may lower the risk of graft versus host disease (GVHD) and of rejection of the peripheral blood graft.

Eligibility criteria: Inclusion Criteria:

* Presence of a suitable related HLA-haploidentical or -matched stem cell donor, or a 10/10 matched unrelated donor
* Eligible diagnoses: myelodysplastic syndrome (MDS) with at least 1 poor-risk feature; small lymphocytic lymphoma (SLL) or chronic lymphocytic leukemia (CLL) with 17p deletion or with progression \< 6 months after a second or greater treatment regimen; T-cell prolymphocytic leukemia (PLL) in partial response or better; interferon- or tyrosine-kinase-refractory chronic myeloid leukemia (CML), or CML in second or subsequent chronic phase; Philadelphia chromosome negative (Ph-) myeloproliferative disease, including myelofibrosis; Multiple myeloma or plasma cell leukemia in partial response or better; Hematologic malignancy in complete remission with minimal residual disease (MRD) detectable by conventional cytogenetics, FISH, flow cytometry, or molecular testing
* Any previous autologous transplant must have occurred \> 3 months ago
* Left ventricular ejection fraction (LVEF) \>= 35%, or shortening fraction \> 25%
* Bilirubin \<= 3.0 mg/dL (unless due to Gilbert's syndrome or hemolysis)
* AST and ALT \<= 5 x institutional upper limit of normal
* FEV1 and FVC \>= 40% of predicted; if unable to perform pulmonary function testing, oxygen saturation \> 92% on room air
* ECOG performance status \<= 2, or Karnofsky/Lansky status \>= 60

Exclusion Criteria:

* Pregnancy or active breastfeeding
* Uncontrolled active infection
* Previous allogeneic transplant
* Active extramedullary leukemia or active central nervous system (CNS) malignant disease

Primary outcomes:
measure: Percentage of Participants Who Are Able to Stop Prophylactic Tacrolimus (D90 Cohort)
timeFrame: Day 90
measure: Percentage of Participants Who Are Able to Stop Prophylactic Tacrolimus (D60 Cohort)
timeFrame: Day 60
Secondary outcomes:
measure: Number of Participants With Grades III-IV Acute GVHD, Days 90-180 (D90)
timeFrame: Between Day 90 and Day 180
measure: Number of Participants With Grades III-IV Acute GVHD, Days 60-180 (D60)
timeFrame: Between Day 60 and Day 180
measure: Number of Participants With Chronic GVHD, Days 90-180 (D90)
timeFrame: Between Day 90 and Day 180
measure: Number of Participants With Chronic GVHD, Days 60-180 (D60)
timeFrame: Between Day 60 and Day 180
measure: Number of Participants Who Experience Graft Failure, Days 90-180 (D90)
timeFrame: Between Day 90 and Day 180
measure: Number of Participants Who Experience Graft Failure, Days 60-180 (D60)
timeFrame: Between Day 60 and Day 180
measure: Number of Participants Who Experience Disease Relapse, Days 90-180 (D90)
timeFrame: Between Day 90 and Day 180
measure: Number of Participants Who Experience Disease Relapse, Days 60-180 (D60)
timeFrame: Between Day 60 and Day 180
measure: Number of Participants Who Experience Non-relapse Mortality, Days 90-180 (D90)
timeFrame: Between Day 90 and Day 180
measure: Number of Participants Who Experience Non-relapse Mortality, Days 60-180 (D60)
timeFrame: Between Day 60 and Day 180
measure: Number of Participants Who Experience Grades III-IV GVHD, Day 360 (D90)
timeFrame: Day 360
measure: Number of Number of Participants Who Experience Grades III-IV GVHD, Day 360 (D60)
timeFrame: Day 360
measure: Number of Number of Participants With Severe Chronic GVHD, Day 360 (D90)
timeFrame: Day 360
measure: Number of Number of Participants With Severe Chronic GVHD, Day 360 (D60)
timeFrame: Day 360
measure: Number of Number of Participants Who Experience Graft Failure, Day 360 (D90)
timeFrame: Day 360
measure: Number of Number of Participants Who Experience Graft Failure, Day 360 (D60)
timeFrame: Day 360
measure: Number of Participants Who Experience Relapse, Day 360 (D90)
timeFrame: Day 360
measure: Number of Participants Who Experience Relapse, Day 360 (D60)
timeFrame: Day 360
measure: Number of Participants Who Experience Non-relapse Mortality, Day 360 (D90)
timeFrame: Day 360
measure: Number of Participants Who Experience Non-relapse Mortality, Day 360 (D60)
timeFrame: Day 360
Other outcomes:
Locations:
city: Baltimore
country: United States
facility: Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
state: Maryland
Study officials:
affiliation: 410-502-7208
name: Amy E DeZern, MD
role: PRINCIPAL_INVESTIGATOR
References: