Clinical trial NCT01621074: Influence of Sodium Bicarbonate on Time-to-exhaustion at Critical Power in Endurance Athletes
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Performance
Lead sponsor: University of Zurich
Sponsor class: OTHER
Collaborators: name: Swiss Federal Institute of Technology
First posted: 2012-06-15
Enrollment: 12
Sex: MALE
Minimum age (years): 18
Maximum age (years): 45
Standard ages: ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: CROSSOVER

Brief summary: During endurance exercise in the heavy and severe intensity domains, the rate at which metabolites that have been associated with the fatigue process (e.g. Pi, ADP, H, and extracellular K) accumulate increases. possibly leading to exercise cessation. Sodium bicarbonate, as a nutritional supplement, has gained attention over the past decades, because it might delay of offset fatigue. To date, there is a controversial discussion about which delivery mode (amount and frequency) might be best in optimizing endurance performance. Since the high ion load consequent to multiple ingestions might increase plasma volume, and consequently decrease bicarbonate concentrations, single acute ingestion could be more beneficial. However, in multi-day competitions or tournaments it might be necessary to use the supplement on a daily basis. Here, the investigators aim at investigating the effects of single dose or multiple dose (on five consecutive days) administration of bicarbonate vs. placebo increases endurance performance and acid-base homeostasis in trained male endurance athletes.


Eligibility criteria: Inclusion criteria: - male

* no cold or temperature at beginning or during the study
* between 18 and 45 years of age
* active in endurance sports (3 to 5 times per week a moderate to hart training)
* non-smoker
* no known cardiovascular or orthopedic problems
* no known limitations of kidney function
* no bearer of a cardiac pacemaker
* no medications with direct influence on the measurements. The whole intake of medicaments has to be declared in the health questionnaire by the participant.
* requirements of the health questionnaire fulfilled

Exclusion criteria: - female

* male and age under 18 or over 45 years
* cold or temperature at the beginning or during the study
* untrained (less than 3 moderate trainings per week)
* smoker
* cardiovascular or orthopedic problems
* limitations of the kidney function
* bearer of a cardiac pacemaker
* medication with direct influence on the measurements. The whole intake of medicaments has to be declared in the health questionnaire by the participant.
* requirements of the health questionnaire not fulfilled

Primary outcomes:
measure: Time-to-exhaustion
timeFrame: 5 weeks
Secondary outcomes:
Other outcomes:
Locations:
city: Zurich
country: Switzerland
facility: University Hospital Zurich, Division of Neurology
state: ZH
Study officials:
affiliation: University Hospital Zurich, Division of Neurology
name: Neurologie: Neurologische Forschung
role: STUDY_DIRECTOR
affiliation: Swiss Federal Institute of Technology Zurich
name: Marco Toigo, PhD
role: PRINCIPAL_INVESTIGATOR
References:
citation: Mueller SM, Gehrig SM, Frese S, Wagner CA, Boutellier U, Toigo M. Multiday acute sodium bicarbonate intake improves endurance capacity and reduces acidosis in men. J Int Soc Sports Nutr. 2013 Mar 26;10(1):16. doi: 10.1186/1550-2783-10-16.