Clinical trial NCT04932837: Level of Immunity, Neutralization of the COVID-19 Virus and Reinfections in Residents of 2 Migrant Workers' Residences
Official title: Determination of the Level of Immunity, Neutralization of the SARS-COV-2 Virus and Reinfections in Residents of 2 Migrant Workers' Residences 10 Months Apart
Study type: OBSERVATIONAL
Overall status: WITHDRAWN
Conditions: SARS-COV-2
Keywords: COVID-19
migrant workers' residences
Immunity
protection
Lead sponsor: Epicentre
Sponsor class: OTHER
Collaborators: name: Medecins Sans Frontieres, Netherlands
name: Institut Pasteur
name: Agence Regionale de Sante d'Ile de France
First posted: 2021-06-21
Enrollment: 0
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: ECOLOGIC_OR_COMMUNITY
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: residents of 2 Migrant Workers

Brief summary: A previous seroprevalence survey showed very high seroprevalence levels among residents of the two among the residents of the two migrant workers' hostels surveyed, indicating a high level of circulation of the virus SARS-COV-2 during the 1st wave of COVID-19. The constitution of a cohort after the event would be an opportunity to obtain opportunity to obtain answers to crucial questions: duration of immunity, potential reinfections potential reinfections, potential re-clustering. Going back to check the serological status seems feasible, especiallyespecially in the Foyers de Travailleurs Migrants (high probability of finding the participants).

There is an obvious scientific interest around the duration of immunity and reinfections in a population highly exposed during the first wave. Several articles document the decline of IgG antibodies in the months following an infection, but very few infection, but very few evaluate the protective character in the medium term (\>=6 months), especially in asymptomatic individuals. We are also concerned about the circulation of We are also concerned about the circulation of new variants and the immunity acquired after infection in residents.

To date, no study on the duration of immunity has been conducted in migrant worker's residences.


Eligibility criteria: Inclusion Criteria:

* All individuals who consented to participate in the 1st study and who consent to participate in this study
* All individuals 18 years of age or older not residing in the 2 MWRs in July 2020 and permanently living in the MWR since September 2020 who consent to participate in this study

Exclusion Criteria:

* Unwillingness to provide informed consent
* Unwillingness to provide blood
* Contraindication to venepuncture

Primary outcomes:
measure: Level and quality of current humoral immune protection in the residents of the two migrant workers' residences
timeFrame: 15 days
Secondary outcomes:
measure: Immunity and protection
timeFrame: 15 days
measure: New infections and screening
timeFrame: 15 days
measure: COVID Vaccination
timeFrame: 15 days
Other outcomes:
Locations:
city: Montreuil
country: France
facility: Foyer de travailleurs migrants
state: Ile De France
city: Villemomble
country: France
facility: Foyer de travailleurs migrants
state: Ile De France
Study officials:
affiliation: Epicentre
name: Elisabeth POULET, MD
role: PRINCIPAL_INVESTIGATOR
References: