Clinical trial NCT06112119: Role of MSCT Volumetry in Assessment of Brain Atrophy in Septic Patients
Official title: Role of Semi-automatic MSCT Volumetry in Assessment of Rapidly Progressive Brain Atrophy in Septic ICU Patients.
Study type: OBSERVATIONAL
Overall status: NOT_YET_RECRUITING
Conditions: Sepsis-Associated Encephalopathy
Lead sponsor: Assiut University
Sponsor class: OTHER
First posted: 2023-11-01
Enrollment: 55
Sex: ALL
Minimum age (years): 16
Maximum age (years): 45
Standard ages: CHILD
ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: RETROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: All the patients will be included within ehs inclusion criteria after giving informed consent from patients or from the hospital board to review patients' medical records, it will include:

* Full history taking.
* Clinically provisinal diagnosis .
* Blood and bacterial culture was performed at the time of admission for all patients .
* Firstly All studies were performed by using a CT device. CT scans measuring brain volume using BCR which is the width between anterior horn of the bilateral lateral ventricle divided by that of the cerebrum at the same height at the caudate nucleus that measuring in particular frontal lobe volume .
* Also using Evan index which is the width between anterior horn of the bilateral lateral ventricles divided by cranial lumen at the same height .
* When increase BCR and EI ,decrease in brain volume ocurr.

Brief summary: assessment of brain atrophy associated with septic ICU patients by using MSCT Volumetry

Detailed description: Sepsis is the leading cause of admission to ICU , the number of patients who survive and discharge from ICU has also increased due to technological advances in ICU however quality of life of these patients after ICU discharge is lower than that of healthy people of a similar age, in particular Sepsis associated encephalopathy associated with brain dysfunction.

We hypothesized that brain damage including brain volume reduction that ocurre in acute phase of Sepsis using CT scan and there finding " relationship to risk factor and outcome".

We compared head CT finding at time of admission with those obtained during the course of the treatment

Eligibility criteria: Inclusion Criteria:

* patients \>16years old with sepsis associated with disturbance in conscious level admitted to ICU

Exclusion Criteria:

* Age\< 16y Brain death Hematological disease Malignant disease Hypoxemia Error in automatic tissue classification Motion artifac

Primary outcomes:
measure: - Correlation between sepsis and brain volume reduction . - Determine the role of the CT scan in assess brain volume in acute phase of sepsis and it,s influences in improvement activities of daily living.
timeFrame: follow up through 10 days after admission in ICU
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
affiliation: Assiut University
name: Nada mohamed abdelmoneim
role: PRINCIPAL_INVESTIGATOR
affiliation: Assiut University
name: sherif mohamed abdelaal
role: STUDY_DIRECTOR
affiliation: Assiut University
name: samy abdelaziz
role: STUDY_DIRECTOR
References:
citation: Nakae R, Sekine T, Tagami T, Murai Y, Kodani E, Warnock G, Sato H, Morita A, Yokota H, Yokobori S. Rapidly progressive brain atrophy in septic ICU patients: a retrospective descriptive study using semiautomatic CT volumetry. Crit Care. 2021 Nov 29;25(1):411. doi: 10.1186/s13054-021-03828-7.