Clinical trial NCT01624831: Social Cognition in Longstanding Psychosis
Official title: Social Cognition in Longstanding Psychosis
Study type: OBSERVATIONAL
Overall status: TERMINATED
Conditions: Schizophrenia
Schizoaffective Disorder
Bipolar Disorder With Psychotic Features
Major Depression With Psychotic Features
Psychosis Not Otherwise Specified (NOS)
Keywords: Psychosis
schizophrenia
schizoaffective disorder
Bipolar disorder with psychotic features
Major depression with psychotic features
Psychosis NOS
Social Cognition
Lead sponsor: University of Arizona
Sponsor class: OTHER
First posted: 2012-06-21
Enrollment: 9
Sex: ALL
Minimum age (years): 18
Maximum age (years): 75
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Individuals with longstanding psychotic disorder (i.e., 5 years or longer in duration)

Brief summary: In the current study, the investigators propose to measure the five domains of social cognition identified by the National Institute of Mental Health (NIMH) as relevant to individuals with psychosis (i.e., theory of mind, attribution style, emotion recognition, social perception, and social knowledge). The investigators will also explore the association between different domains of social cognition and outcomes relevant to psychotic disorder (e.g., symptomatology, social functioning, and vocational functioning).

Detailed description: There is growing evidence that individuals with longstanding psychotic disorders suffer from deficits in social cognition (i.e., the cognitive skills needed to successfully navigate social interactions). However, to date, there have been few attempts to measure multiple components of social cognition within the same population of individuals with psychosis. Thus, the interrelationships between various aspects of social cognition remain unclear. In the current study, the investigators propose to measure the five domains of social cognition identified by NIMH as relevant to individuals with psychosis (i.e., theory of mind, attribution style, emotion recognition, social perception, and social knowledge). The investigators will also explore the association between different domains of social cognition and outcomes relevant to psychotic disorder (e.g., symptomatology, social functioning, and vocational functioning).

Eligibility criteria: Inclusion Criteria:

* Diagnosis of a schizophrenia spectrum disorder or an affective disorder with psychotic features per the Diagnostic and Statistical Manual of Mental Disorders-IV-Text Revised (DSM-IV-TR) criteria using the Structured Clinical Interview for the DSM-IV.
* Duration of psychotic symptoms greater than or equal to 5 years determined using the Symptom Onset in Schizophrenia Inventory
* Age 18-75
* No evidence of mental retardation.
* Able to provide informed consent as evidenced by passing the informed consent quiz with a score of 80% or greater.
* Fluent in English as assessed per self-report from participant

Exclusion Criteria:

* Unwilling or unable to complete study assessments (e.g., unable to read self-report questionnaires)
* Subject is currently pregnant per subject's report

Primary outcomes:
measure: Emotion Recognition
timeFrame: Baseline and 6 months
measure: Attribution Style
timeFrame: Baseline and 6 months
measure: Social Perception
timeFrame: Baseline and 6 months
measure: Social Knowledge
timeFrame: Baseline and 6 months
measure: Theory of Mind
timeFrame: Baseline and 6 months
Secondary outcomes:
measure: Anxiety
timeFrame: Baseline and 6 months
measure: Depression
timeFrame: Baseline and 6 months
measure: Psychosis
timeFrame: Baseline and 6 months
measure: Social Functioning
timeFrame: Baseline and 6 months
measure: Service Utilization
timeFrame: Baseline and 6 months
measure: Self-Determination Needs Satisfaction
timeFrame: Baseline and 6 months
measure: Locus of Control
timeFrame: Baseline and 6 months
measure: Cognitive representation of illness
timeFrame: Baseline and 6 months
measure: Emotional Awareness
timeFrame: Baseline and 6 months
measure: Mindfulness
timeFrame: Baseline and 6 months
measure: Medication adherence
timeFrame: Baseline and 6 months
measure: Neuropsychological functioning
timeFrame: Baseline and 6 months
measure: Social Support
timeFrame: Baseline and 6 months
measure: Illness Uncertainty
timeFrame: Baseline and 6 months
measure: Relationship with familial caregivers
timeFrame: Baseline and 6 months
measure: Self-efficacy
timeFrame: Baseline and 6 months
measure: Experience of Stigma
timeFrame: Baseline and 6 months
measure: quality of life
timeFrame: Baseline and 6 months
measure: stage of recovery
timeFrame: Baseline and 6 months
measure: Coping skills
timeFrame: Baseline and 6 months
measure: Time perspective
timeFrame: Baseline and 6 months
Other outcomes:
Locations:
city: Tucson
country: United States
facility: University of Arizona Department of Psychiatry
state: Arizona
Study officials:
affiliation: The Ohio State Univerity
name: Nicholas Breitborde, Ph.D.
role: PRINCIPAL_INVESTIGATOR
References: