Clinical trial NCT06649916: Word Learning from Parentese in Autistic Children
Official title: Autism Word Learning and Infant Directed-Speech
Study type: INTERVENTIONAL
Overall status: RECRUITING
Phase: NA
Conditions: Autism
Autism Spectrum Disorder
Neurodevelopmental Disorders
Keywords: autism
word learning
language development
Lead sponsor: The University of Texas at Dallas
Sponsor class: OTHER
Collaborators: name: National Institute on Deafness and Other Communication Disorders (NIDCD)
First posted: 2024-10-21
Enrollment: 100
Sex: ALL
Minimum age (years): 18
Maximum age (years): 59
Standard ages: CHILD
Accepts healthy volunteers: yes
Allocation: NON_RANDOMIZED
Intervention model: PARALLEL
Primary purpose: BASIC_SCIENCE

Brief summary: The overall objective of this research is to determine whether parentese delivered in the video format (Aim 1) and in live interaction (Aim 2) facilitates novel word learning in autistic children and to investigate if there are factors that influence the effect of parentese on word learning (Aim 3).

Detailed description: Caregivers frequently use parentese, also known as infant-directed speech (IDS), when speaking to young children. Compared to adult registered speech, parentese is typically characterized by greater pitch variation, longer duration, and louder volume. Parentese facilitates early language development in typically developing (TD) children. However, it remains unknown whether the facilitative effect of parentese on language learning can be generalized to clinical populations such as autistic children given that core autism features (e.g., sensory and social communication differences) may interact with how they process and learn from parentese. Most autistic children do not reach age-appropriate language ability even if they receive timely early intervention. Determining if autistic children can learn language from parentese, a common way language input is provided to young children, is a critical first step toward understanding whether language input needs to be adjusted to optimize their language development.

The overall objective of this research is to determine whether parentese facilitates novel word learning in autistic children and to investigate if the effect of parentese is conditional upon input factors (recorded parentese vs live parentese presented in social interaction) and child factors (extreme responses to auditory input, social motivation). In Aim 1, the investigators will use a video-based word learning paradigm to determine the effect of recorded parentese on novel word learning in autistic children compared to language-matched TD peers. Aim 2 focuses on the effect of live parentese on novel word learning: an experimenter will teach children two novel words, presented in live parentese or live parentese, during social interaction. Aim 3 will examine whether child factors (extreme responses to auditory input, social motivation) explain variability in word learning accuracy from recorded parentese and live parentese in the autistic group. Children's extreme responses to auditory input (including hyper- and hypo-responsiveness) and social motivation will be measured using caregiver questionnaires and will be used to predict word learning accuracy from recorded parentese (Aim 1) and live parentese (Aim 2) in the autistic group.

Eligibility criteria: Inclusion Criteria:

* children with or without a diagnosis of ASD between 18 and 59 months

Exclusion Criteria:

* hears another language more than 10% of time based on parent report
* has uncorrected visual impairment or hearing impairment
* has developmental disorders or medical conditions other than ASD that affect language or cognition (excepting psychiatric conditions often comorbid with ASD such as ADHD)

Primary outcomes:
measure: Proportion of time during which children's eye gaze is directed toward the target object
timeFrame: 300 ms after the target words are introduced
Secondary outcomes:
Other outcomes:
Locations:
city: Richardson
country: United States
facility: University of Texas at Dallas
state: Texas
Study officials:
affiliation: University of Texas at Dallas
name: Pumpki L. Su, PhD
role: PRINCIPAL_INVESTIGATOR
References: