Clinical trial NCT05542758: High-Intensity Interval Training for Older Adults
Official title: High-Intensity Interval Training: Impacts on Function, Neuromuscular Control, and Muscle Architecture
Study type: INTERVENTIONAL
Overall status: ACTIVE_NOT_RECRUITING
Phase: NA
Conditions: Age-Related Sarcopenia
Keywords: geriatrics
high-intensity interval training
rehabilitation
Lead sponsor: Creighton University
Sponsor class: OTHER
Collaborators: name: University of Nebraska
First posted: 2022-09-15
Enrollment: 60
Sex: ALL
Minimum age (years): 65
Maximum age (years): 95
Standard ages: OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: NA
Intervention model: SINGLE_GROUP
Intervention model description: All participants will receive the 12-week high-intensity intervention.
Primary purpose: PREVENTION

Brief summary: This study will examine differences in a 12 week high-intensity interval training regimen. The Total Body HIIT program incorporates a resistance (circuit) and an anaerobic (bike) component in older adults. The specific objectives focus on examining cardiovascular endurance, neuromuscular function, and muscle architecture.


Eligibility criteria: Inclusion Criteria:

* 65-95 years of age or older
* Physical independent (Barthel Index)
* Physician clearance to participate
* No medication changes in previous 30 days
* No structured resistance training program in previous 6 months

Exclusion Criteria:

* Contraindications to high-intensity exercise39 (PAR-Q Questionnaire)
* Severe mental impairment (\<18 on Montreal Cognitive Assessment)
* Neurodegenerative or acute neurological diagnoses (e.g., Parkinson's disease, stroke, traumatic brain injury)

Primary outcomes:
measure: Change in 6-Min Walk Test performance from baseline to following HIIT intervention
timeFrame: change from baseline to immediately after the HIIT intervention
measure: Change in Voluntary Muscle Strength Tests (Isokinetics) from baseline to following HIIT intervention
timeFrame: change from baseline to immediately after the HIIT intervention
measure: Change in Voluntary Muscle Strength Tests (Isometrics) from baseline to following HIIT intervention
timeFrame: change from baseline to immediately after the HIIT intervention
measure: Change in Evoked Muscle Function Assessments: Evoked Peak Force from baseline to following HIIT intervention
timeFrame: change from baseline to immediately after the HIIT intervention
measure: Change in Evoked Muscle Function Assessments: Evoked Peak Rate of Force Development from baseline to following HIIT intervention
timeFrame: change from baseline to immediately after the HIIT intervention
measure: Change in Rate of Muscle Activation from baseline to following HIIT intervention
timeFrame: change from baseline to immediately after the HIIT intervention
measure: Change in Voluntary Electromechanical Delay from baseline to following HIIT intervention
timeFrame: change from baseline to immediately after the HIIT intervention
measure: Change in Ultrasound-based Muscle Architecture: Cross-sectional Area from baseline to following HIIT intervention
timeFrame: change from baseline to immediately after the HIIT intervention
measure: Change in Ultrasound-based Muscle Architecture: Echo Intensity from baseline to following HIIT intervention
timeFrame: change from baseline to immediately after the HIIT intervention
measure: Change in Muscle Biopsy-based Muscle Architecture from baseline to following HIIT intervention
timeFrame: change from baseline to immediately after the HIIT intervention
Secondary outcomes:
measure: Change in V02 peak from baseline to following HIIT intervention
timeFrame: change from baseline to immediately after the HIIT intervention
measure: Change in Gait Speed from baseline to following HIIT intervention
timeFrame: change from baseline to immediately after the HIIT intervention
measure: Change in Functional Lower Body Strength from baseline to following HIIT intervention
timeFrame: change from baseline to immediately after the HIIT intervention
measure: Change in Functional Upper Body Strength from baseline to following HIIT intervention
timeFrame: change from baseline to immediately after the HIIT intervention
measure: Change in Balance: Center of Pressure Excursion from baseline to following HIIT intervention
timeFrame: change from baseline to immediately after the HIIT intervention
measure: Change in Balance: Functional Gait Assessment from baseline to following HIIT intervention
timeFrame: change from baseline to immediately after the HIIT intervention
measure: Change in Balance: Berg Balance Scale from baseline to following HIIT intervention
timeFrame: change from baseline to immediately after the HIIT intervention
measure: Change in Health-Related Quality of Life from baseline to following HIIT intervention
timeFrame: change from baseline to immediately after the HIIT intervention
Other outcomes:
Locations:
city: Omaha
country: United States
facility: Creighton University
state: Nebraska
Study officials:
References: