Clinical trial NCT00952835: Evaluation of Different Disease Control Indices in Children With Asthma and Rhinitis
Official title: Evaluation of Different Disease Control Indices in Children With Asthma and Rhinitis
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Asthma
Rhinitis
Keywords: Asthma
rhinitis
EIB
Exhaled Nitric oxide
lung function
vitamin d
Lead sponsor: Universita di Verona
Sponsor class: OTHER
Collaborators: name: Azienda Ospedaliera Universitaria Policlinico
First posted: 2009-08-06
Enrollment: 1000
Sex: ALL
Minimum age (years): 5
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: CASE_ONLY
Time perspective: CROSS_SECTIONAL
Sampling method: PROBABILITY_SAMPLE
Study population: children with asthma and/or rhinitis visited at the outpatients clinic at the University of Verona will be invited to participate to the study

Brief summary: In this study will be consecutive enrolled children with asthma (classified according to GINA guidelines) and rhinitis (classified by ARIA guidelines); the investigators will research clinical personal and parental history regarding allergic diseases, exposition to passive smoking and interpretate hematochemical parameters markers of atopy. Skin Prick Tests will be performed. In this study the investigators will evaluate lung function parameters (spirometry with bronchial reversibility test and exercise induced bronchoconstriction, oscillometry, respiratory plethysmography, etc.), airway inflammatory indices such as exhaled nitric oxide at different flows, exhaled and nasal temperature, nasal cytology.

The aim of the study will be to evaluate possible correlation between these different parameters and clinical status of the patients.

Detailed description: Each patients will be evaluated by spirometry and then he will undergo exercise challenge in order to evaluate exercise-induced bronchoconstriction as a marker of asthma control. The test of the challenge will be correlate with childhood Asthma control test score,levels of control (GINA classification)and the different markers of airway inflammation and atopy.

Eligibility criteria: Inclusion Criteria:

* patient with asthma and rhinitis

Exclusion Criteria:

* age \<5 years
* chronic respiratory diseases

Primary outcomes:
measure: Evaluation of Different Disease Control Indices in Children With Asthma and Rhinitis
timeFrame: Evaluation of Different Disease Control Indices in Children With Asthma and Rhinitis
Secondary outcomes:
Other outcomes:
Locations:
city: Verona
country: Italy
facility: Pediatric department University of Verona
Study officials:
affiliation: Universita di Verona
name: Attilio Boner, MD
role: PRINCIPAL_INVESTIGATOR
References:
citation: Chinellato I, Piazza M, Peroni D, Sandri M, Chiorazzo F, Boner AL, Piacentini G. Bronchial and alveolar nitric oxide in exercise-induced bronchoconstriction in asthmatic children. Clin Exp Allergy. 2012 Aug;42(8):1190-6. doi: 10.1111/j.1365-2222.2012.03973.x.
citation: Peroni DG, Cattazzo E, Chinellato I, Piazza M, Tezza G, Boner AL, Piacentini GL. Nasal mucosa temperature as a marker of disease in children with allergic rhinitis. Am J Rhinol Allergy. 2012 Jul-Aug;26(4):e115-8. doi: 10.2500/ajra.2012.26.3803.