louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT02464800: Efficacy of Higher Cutting Rate in Microincision Vitrectomy for Proliferative Diabetic Retinopathy
Official title: Efficacy of Higher Cutting Rate in Microincision Vitrectomy for Proliferative Diabetic Retinopathy
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Proliferative Diabetic Retinopathy
Keywords: diabetic retinopathy
Lead sponsor: Kyorin University
Sponsor class: OTHER
First posted: 2015-06-08
Enrollment: 326
Sex: ALL
Minimum age (years): 20
Maximum age (years): 90
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: CASE_CONTROL
Time perspective: RETROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: The patients who underwent 25-gauge vitrectomy for proliferative diabetic retinopathy with higher cutting rate instruments or conventional instruments

Brief summary: The medical records of 393 eyes of 326 patients with severe proliferative diabetic retinopathy were reviewed. Higher cutting rate instruments (5000 cut per minute) were used in 174 eyes and conventional instruments in 219 eyes (2500 cut per minute). The visual outcome and incidences of intraoperative and postoperative complications were compared.


Eligibility criteria: Inclusion Criteria:

* The inclusion criteria were patients who had persistent vitreous hemorrhage, fibrovascular proliferation affecting the macula, or tractional RD and who had a follow-up for more than 6 months.

Exclusion Criteria:

* The eyes with follow-up less than 6 months

Primary outcomes:
measure: Visual acuity
timeFrame: 6 months
Secondary outcomes:
measure: Retinal reattachment
timeFrame: 6 months
Other outcomes:
Locations:
city: Mitaka
country: Japan
facility: Makoto Inoue
state: Tokyo
Study officials:
References:
Clinical trial NCT00656500: Quitline Use in Surgical Patients
Official title: Increasing QUITPLAN Helpline Utilization in Surgical Patients
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Tobacco Dependence
Keywords: surgical patients
cigarette smoking
postoperative complications
telephone counseling
quitlines
Lead sponsor: Mayo Clinic
Sponsor class: OTHER
First posted: 2008-04-11
Enrollment: 300
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: SINGLE_GROUP
Primary purpose: PREVENTION

Brief summary: Elective surgery represents a teachable moment to deliver tobacco interventions. The overall goal of this proposal is to increase the utilization of the QUITPLANSM Helpline by surgical patients who smoke. Two specific aims will be pursued using a multidisciplinary research team. In the first aim, we will develop a practice-based intervention to promote QUITPLANSM Helpline utilization by surgical patients (Specific Aim 1A) using a combination of key informant interviews (approximately 30 subjects), and focus groups (approximately 25 subjects) then develop methods to educate providers in its implementation (Specific Aim 1B) and test their effectiveness in approximately 20 providers. In the second aim, we will perform a randomized clinical trial of this intervention in 300 patients scheduled for elective surgery, with the primary outcome being utilization of the QUITPLANSM Helpline (Specific Aim 2). Subjects will be randomized to receive either the intervention developed in Specific Aim 1, or a brief control intervention.


Eligibility criteria: Inclusion Criteria:

* Patients ≥ 18 yrs. scheduled for elective surgery at Mayo Clinic Rochester.
* Current smoking before the scheduling of surgery, defined as \> 100 cigarettes lifetime consumption and self-reports of smoking either every day or some days. Patients who are in the midst of a quit attempt initiated since learning about surgery are eligible.

Exclusion Criteria:

* Patient is not available for telephone follow-up

Primary outcomes:
measure: Completion of one quitline counseling session
timeFrame: Three months postoepratively
Secondary outcomes:
measure: Smoking behavior at six months postoperatively
timeFrame: six months postoperatively
Other outcomes:
Locations:
city: Rochester
country: United States
facility: Mayo Clinic
state: Minnesota
Study officials:
affiliation: Mayo Clinic
name: David O. Warner, M.D.
role: PRINCIPAL_INVESTIGATOR
References:
citation: Warner DO, Klesges RC, Dale LC, Offord KP, Schroeder DR, Shi Y, Vickers KS, Danielson DR. Clinician-delivered intervention to facilitate tobacco quitline use by surgical patients. Anesthesiology. 2011 Apr;114(4):847-55. doi: 10.1097/ALN.0b013e31820d868d.
Clinical trial NCT04902300: Prevalence of Internet Addiction Among Adolescent
Official title: Prevalence of Internet Addiction Among Adolescent
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Internet Addiction
Keywords: Adolescent
Internet addiction
Prevalence
Lead sponsor: Université de Reims Champagne-Ardenne
Sponsor class: OTHER
First posted: 2021-05-26
Enrollment: 4750
Sex: ALL
Minimum age (years): 14
Maximum age (years): 20
Standard ages: CHILD
ADULT
Accepts healthy volunteers: yes
Observational model: CASE_ONLY
Time perspective: CROSS_SECTIONAL
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Adolescent attending high school

Brief summary: Internet is now a tool available 24 hours a day, at a lower cost and accessible almost anywhere. Internet addiction could be defined as the inability to control one's Internet use and the continuation of this behavior despite the occurrence of negative consequences.

Adolescence is a time of vulnerability to addiction, due to social and neurobiological factors.

Detailed description: The aim of the study is to evaluate prevalence of internet addiction among adolescent attending high school

Eligibility criteria: Inclusion Criteria:

* adolescent attending high school
* agreeing to participate in the study

Exclusion Criteria:

* None

Primary outcomes:
measure: internet addiction
timeFrame: Day 0
Secondary outcomes:
Other outcomes:
Locations:
city: Reims
country: France
facility: Université de Reims Champagne-Ardenne
Study officials:
affiliation: Université de Reims Champagne-Ardenne
name: Olivier CORPEL, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT02657200: Knowledge, Attitude and Practices of Flemish Midwifes Regarding Spontaneous Abortion
Official title: Knowledge, Attitude and Practices of Flemish Midwifes Regarding Spontaneous Abortion
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Spontaneous Abortion
Keywords: miscarriage
Flanders
spontaneous abortion
KAP
midwives
Lead sponsor: University Ghent
Sponsor class: OTHER
Collaborators: name: Odisee
First posted: 2016-01-15
Enrollment: 647
Sex: ALL
Minimum age (years): 20
Maximum age (years): 70
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: HEALTH_SERVICES_RESEARCH

Brief summary: KAP-study in Flemish midwives with intramural employment

Detailed description: The study will be conducted using a self designed questionnaire administered in midwives who are employed within a Flemish hospital in one of the following departments: maternity, maternal intensive care, (intensive) neonatology, reproductive medicine, gynaecology, delivery and prenatal care. The questionnaire assesses the knowledge, attitude and practices of the midwives regarding spontaneous abortion.

Eligibility criteria: Inclusion Criteria:

* midwives who are employed within a Flemish hospital in one of the following departments: maternity, maternal intensive care, (intensive) neonatology, reproductive medicine, gynaecology, delivery and prenatal care

Exclusion Criteria:

* all others

Primary outcomes:
measure: knowledge, attitude and practices regarding spontaneous abortion
timeFrame: 6 months
Secondary outcomes:
Other outcomes:
Locations:
city: Brugge
country: Belgium
facility: AZ Sint-Jan
state: West-Vlaanderen
Study officials:
affiliation: University Ghent
name: Els Clays, Phd
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT04639700: Intervention for Caregivers of Patients Who Have Recently Undergone HSCT
Official title: A Pilot Study to Evaluate the Feasibility of an Intervention for Caregivers of Patients Who Have Recently Undergone HSCT
Study type: INTERVENTIONAL
Overall status: WITHDRAWN
Phase: NA
Conditions: Caregiver Anxiety
Caregiver Distress
Caregiver Health Related QOL
Keywords: Hematopoietic stem cell transplantation
Lead sponsor: Case Comprehensive Cancer Center
Sponsor class: OTHER
First posted: 2020-11-20
Enrollment: 0
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: SUPPORTIVE_CARE

Brief summary: The purpose of this study is to find out if providing support to caregivers of patients who have recently had a HSCT is possible and helpful.

Detailed description: This study will test the feasibility, acceptability, usability, satisfaction and preliminary efficacy of a behavioral (psychoeducation) intervention. All participants will receive the standard post-hospital HSCT information for patient follow-up care as provided by the patient's oncologist. In addition, the all participants will receive 4 individual sessions with an interventionist.

Eligibility criteria: Inclusion Criteria:

* An adult family or friend of a patient who has been discharged from the hospital in the past 1-2 weeks after receiving HSCT
* Identifies himself/herself as the caregiver who will be responsible for the patient's care post-HSCT
* Has English as their primary language

Exclusion Criteria:

-Not meeting inclusion criteria

Primary outcomes:
measure: Acceptability Scale scores
timeFrame: At 2 months
measure: System Usability Scale scores
timeFrame: At 2 months
measure: Mean caregiver satisfaction scores
timeFrame: At the end of each intervention session and end of study evaluation, up to 2 months
measure: Percent of enrollment of eligible participants
timeFrame: At 2 months
measure: Percent of participants completing intervention
timeFrame: At 2 months
measure: Retention rate
timeFrame: At 2 months
measure: Average time to recruit dyads in months
timeFrame: At 2 months
measure: Data collection completion rate
timeFrame: At 2 months
Secondary outcomes:
measure: NCCN Distress Thermometer scores
timeFrame: At baseline and at 2 months
measure: PROMISR Short Form v1.0 - Anxiety
timeFrame: At baseline and at 2 months
measure: PROMISRv.1.2 - GlobalHealth scores
timeFrame: At baseline and at 2 months
Other outcomes:
Locations:
Study officials:
affiliation: Case Western Reserve University
name: Sara Douglas, PhD, RN
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT04262700: Customer Outcomes & Value Experiencing A New Monitoring Technology
Official title: Customer Outcomes & Value Experiencing A New Monitoring Technology
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Diabetes Mellitus
Lead sponsor: LifeScan Scotland Ltd
Sponsor class: INDUSTRY
First posted: 2020-02-10
Enrollment: 170
Sex: ALL
Minimum age (years): 16
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: OTHER

Brief summary: To investigate whether novel insight features in new Blood Glucose Monitoring System (BGMs) can improve glycemic control.


Eligibility criteria: Inclusion Criteria Summary:

* Diagnosed with Type 1 diabetes mellitus or Type 2 diabetes mellitus for ≥ 3 month prior to screening
* Currently performing self-monitoring of blood glucose (SMBG) at home for diabetes management decisions
* Willingness to notify the study staff if they become pregnant during the study
* Willing to sign an informed consent

Exclusion Criteria Summary:

* Currently using a continuous or flash glucose monitoring
* Currently pregnant or planning pregnancy within duration of study or breast feeding; subjects who become pregnant during the study will be withdrawn.
* Conflict of Interest

Primary outcomes:
measure: A1c change from baseline after 12 weeks
timeFrame: 12 weeks
Secondary outcomes:
Other outcomes:
Locations:
city: Edinburgh
country: United Kingdom
facility: Royal Infirmary of Edinburgh
state: Lothian
city: Inverness
country: United Kingdom
facility: Highland Diabetes Institute
Study officials:
References:
Clinical trial NCT00512200: Postoperative Cognitive Dysfunction in Geriatric Patients
Official title: Postoperative Cognitive Dysfunction in Geriatric Patients: the Role of Intraoperative Cerebral Perfusion and Perioperative Anticholinergic Medication
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Delirium, Dementia, Amnestic, Cognitive Disorders
Postoperative Complications
Memory Disorders
Lead sponsor: University Hospital, Basel, Switzerland
Sponsor class: OTHER
First posted: 2007-08-07
Enrollment: 280
Sex: ALL
Minimum age (years): 65
Standard ages: OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Patients undergoing elective major surgery under general anesthesia

Brief summary: Geriatric patients have a high risk of developing postoperative cognitive deficits. Hypothetical causes are insufficient intraoperative cerebral perfusion or drugs that are administered in the perioperative setting. This study will investigate the role of these two factors in patients aged 65 or older undergoing elective surgical procedures under general aesthesia. Non-invasive techniques will be used to monitor intraoperative cerebral perfusion and anticholinergic activity in the patient's blood is determined. Data will be compared to those of a young (20-40 year old) group of patients undergoing elective surgical procedures using an identical anesthetic technique. A second control group of healthy volunteers older than 65 will be investigated to quantify practice effects with repeated testing of cognitive functions.


Eligibility criteria: Inclusion Criteria:

* Elective surgical procedure under general anaesthesia

Exclusion Criteria:

* History of cerebrovascular disease
* Mini Mental status \<23
* Cardiac surgery
* Neurosurgery

Primary outcomes:
measure: Change in cognitive function due to surgery under general aesthesia
timeFrame: cognitive function measured prior to and after surgery
Secondary outcomes:
Other outcomes:
Locations:
city: Basel
country: Switzerland
facility: Department of Anaesthesia, University Hospital Basel
state: Basel-Stadt
Study officials:
affiliation: Department of Anaesthesia, University Hospital Basel
name: Luzius A Steiner, MD, Prof.
role: PRINCIPAL_INVESTIGATOR
References:
citation: Goettel N, Patet C, Rossi A, Burkhart CS, Czosnyka M, Strebel SP, Steiner LA. Monitoring of cerebral blood flow autoregulation in adults undergoing sevoflurane anesthesia: a prospective cohort study of two age groups. J Clin Monit Comput. 2016 Jun;30(3):255-64. doi: 10.1007/s10877-015-9754-z. Epub 2015 Aug 19.
Clinical trial NCT04218500: The Effectiveness and Safety of Niacinamide 4% and Virgin Coconut Oil 30% for Secondary Prevention of Occupational Hand Dermatitis
Official title: Comparison of the Effectiveness and Safety Between Moisturizing Cream Containing Niacinamide 4% and Virgin Coconut Oil 30% for Secondary Prevention of Occupational Hand Hermatitis in Intensive Care Unit Nurses: a Double Blind Randomized Clinical Trial
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Contact Dermatitis of Hands
Keywords: Occupational Hand Dermatitis
Moisturizer
Niacinamide
Virgin coconut oil
HECSI
TEWL
SCap
Lead sponsor: Indonesia University
Sponsor class: OTHER
First posted: 2020-01-06
Enrollment: 92
Sex: ALL
Minimum age (years): 18
Maximum age (years): 58
Standard ages: ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Intervention model description: There were 46 subjects in the niacinamide 4% arm and 46 subjects in the VCO 30% arm
Primary purpose: PREVENTION

Brief summary: Occupational hand dermatitis (OHD) often occurs in intensive care unit (ICU) nurses, especially in individuals who are vulnerable due to irritant exposure e.g. hand rub alcohol and repeated hand washing activities. The use of moisturizer is one of the recommendations for skin care in OHD. Niacinamide which has anti-inflammatory effects and can improve the skin barrier function. Virgin coconut oil (VCO) is rich in lipids and lauric acid, and has an occlusive effect. Until now there are no guidelines and reference types of moisturizers for secondary prevention in DTAK.

Detailed description: The aim of this study is identify the effectiveness and safety between moisturizing cream containing niacinamide 4% and VCO 30% for secondary prevention of occupational hand dermatitis in ICU nurses This study also measured HECSI , TEWL, and SCap before and after treatment

Eligibility criteria: Inclusion Criteria:

ICU nurses who:

* Sign the informed consent of the study after receiving explanation before all activity related with this study begin.
* Has Occupation Hand Dermatitis that fulfill the Mathias criteria with dermatitis severity mild to moderate which the score is 1, 2 or 3 corresponding with Investigator Global Assesment (IGA)
* Agree to follow the study protocol

Exclusion Criteria:

* History of allergic or irritate by Niacinamide or VCO or other component in moisturizer
* Receiving medium to high potency of topical Corticosteroid or systemic immunosupresant therapy or history of oral corticosteroid therapy in the last 1 month

Primary outcomes:
measure: HECSI
timeFrame: 14 days
measure: HECSI
timeFrame: 28 days
measure: TEWL
timeFrame: 14 days
measure: TEWL
timeFrame: 28 days
measure: SCap
timeFrame: 14 days
measure: SCap
timeFrame: 28 days
Secondary outcomes:
Other outcomes:
Locations:
city: Jakarta Pusat
country: Indonesia
facility: Faculty of Medicine, Universitas Indonesia
state: Jakarta
Study officials:
affiliation: Fakultas Kedokteran Universitas Indonesia
name: Dermatology and Venereology Departement
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT06623500: Iodine Nutrition Status and Clinical Characteristics of Thyroid Cancer
Official title: Prospective Cohort Study on Clinical Characteristics of Thyroid Cancer in Different Iodine Status Areas
Study type: OBSERVATIONAL
Overall status: RECRUITING
Conditions: Thyroid Cancer
Lead sponsor: Shandong Provincial Hospital
Sponsor class: OTHER_GOV
First posted: 2024-10-02
Enrollment: 1600
Sex: ALL
Minimum age (years): 18
Maximum age (years): 65
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: Three sub centers were selected in high iodine (Jining/Liaocheng/Heze) and moderate iodine (Jinan/Shenyang/Haerbin) areas respectively. Patients lived in the above-mentioned regions at least for 5 years who was diagnosed as thyroid cancer and underwent thyroid surgery in branch hospitals from 2012 to 2019 were recruited.

Brief summary: The effect of iodine nutritional status on thyroid cancer has been controversial for many years. We designed a prospective cohort study that recruiting patients in different iodine areas who underwent thyroid cancer surgery in branch hospitals from 2012 to 2019，and follow up their clinical outcomes. We aimed to analyse the relationship between regional iodine nutrition level and pathological types, clinical features, and prognosis of thyroid cancer.

Detailed description: Three sub centers were selected in high iodine (Jining/Liaocheng/Heze) and moderate iodine (Jinan/Shenyang/Haerbin) areas respectively. Patients lived in the above-mentioned regions for at least 5 years and diagnosed as thyroid cancer and underwent thyroid surgery in branch hospitals from 2012 to 2019 were recruited.

Eligibility criteria: Inclusion Criteria:

1. Age range: 18\~65 years old, gender not limited;
2. Living in the selected region for at least 5 years;
3. Patients who underwent thyroid surgery at various research centers were pathologically diagnosed with thyroid cancer;
4. The clinical data （general information、surgical scope 、pathological report、utrasonic report, etc ）of the case is complete.

Exclusion Criteria:

1. Diagnosed as other types of cancer or thyroid metastatic cancer;
2. There are serious comorbidities such as heart, liver, and kidney diseases present;
3. Unable to follow up on prognostic information.

Primary outcomes:
measure: Number of participants with recurrence
timeFrame: from enrollment to the final follow-up at 5 years
measure: Number of participants with distant metastasis
timeFrame: from enrollment to the final follow-up at 5 years
measure: All-cause mortality
timeFrame: from enrollment to the final follow-up at 5 years
Secondary outcomes:
Other outcomes:
Locations:
city: Jinan
country: China
facility: Shandong Provincial Hospital
state: Shandong
Study officials:
References:
Clinical trial NCT06779500: Pre-hospital Care in Burn Patients Presenting to Tertiary Care Centers of Nepal
Official title: Pre-hospital Care in Burn Patients Presenting to Tertiary Care Centers of Nepal
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Burns
Keywords: Burn injuries
Burn resuscitation
Pre-hospital care
Lead sponsor: Tribhuvan University Teaching Hospital, Institute Of Medicine.
Sponsor class: OTHER
First posted: 2025-01-16
Enrollment: 196
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: CASE_ONLY
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Burn patients presenting to a tertiary care center with diverse demographics, including variations in age, gender, socioeconomic status, and location, primarily from urban and rural settings in Nepal.

Brief summary: This cross-sectional study investigates pre-hospital practices among burn patients presenting to a tertiary care center in Nepal. It examines first aid measures, timelines to medical care, resuscitation protocols, and factors contributing to delays. Findings aim to highlight gaps in burn care and inform strategies to improve patient outcomes and management practices in resource-limited settings.

Detailed description: Burn injuries are a major public health concern in low- and middle-income countries, contributing significantly to morbidity and disability-adjusted life years (DALYs) lost. This study focuses on understanding the pre-hospital care practices among burn patients in Nepal, a region with limited burn care resources and high incidence rates. Using structured interviews and clinical data, the study explores the type and adequacy of first aid provided, factors influencing delays in accessing tertiary care, and the effectiveness of initial resuscitation. By identifying gaps in awareness, infrastructure, and healthcare delivery, the study seeks to propose actionable recommendations for enhancing burn care systems and improving outcomes for burn patients in Nepal.

Eligibility criteria: Inclusion Criteria:

* Patients of all ages, genders, and backgrounds admitted to the study site with a primary diagnosis of burn injuries.

Exclusion Criteria:

* Patients with life-threatening injuries accompanying burns.
* Patients with a documented history of prior burn injuries.
* Individuals who decline to provide informed consent.

Primary outcomes:
measure: Documentation of First Aid Practices Among Burn Patients
timeFrame: within 1st hour of burn
Secondary outcomes:
measure: Resuscitation Received in the First 24 Hours
timeFrame: First 24 hours after injury.
Other outcomes:
Locations:
city: Kathmandu
country: Nepal
facility: Ishwor Thapaliya
state: Bagmati
Study officials:
References: