Clinical trial NCT06063135: Effects of Physical Exercise Timing On Strength and Cardiometabolic Health
Official title: Effects of Physical Exercise Timing On Strength and Cardiometabolic Health
Study type: INTERVENTIONAL
Overall status: ACTIVE_NOT_RECRUITING
Phase: NA
Conditions: Physical Inactivity
Lead sponsor: University of Basel
Sponsor class: OTHER
First posted: 2023-10-02
Enrollment: 152
Sex: ALL
Minimum age (years): 60
Maximum age (years): 80
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: PREVENTION

Brief summary: Physical exercise is well known to improve human health. Current guidelines provide recommendations on the frequency, intensity, type and duration of exercise. However, they do not provide recommendations for the time of day, exercise should be performed. This is surprising considering that the influence of timing of behaviors such as sleep or nutrition as well as the impact of the circadian timing system on health are well documented. Further, there is evidence for diurnal variation in maximum performance which enables individuals to exercise with different intensities at different times of day, which in the long term might affect physical adaptations to exercise. Thus, this research study investigates if exercise timing impacts human health.


Eligibility criteria: Inclusion Criteria:

* BMI 18.5 - 30 kg/m2

Exclusion Criteria:

* Structured resistance training within the last six months
* Ongoing shift work
* Irregular bedtime (\> 2 hours variation in habitual bed time)
* Smoking
* Travels across more than two time zones within the last four weeks
* Inability to follow the study procedures (e.g. due to language barriers, psychological disorders, dementia, etc.)
* Known pregnancy or lactating women
* Participation in any other clinical trial within the last four weeks
* Medical condition that is a contra indicator for resistance training, endurance training, or exercising until maximum exhaustion including insufficiently controlled blood pressure (systolic \> 170 mmHg, diastolic \> 100 mmHg), ongoing cancer treatment, unstable angina pectoris, uncontrolled bradyarrhythmia or tachyarrhythmia, severe uncorrected valvular heart disease, clinically relevant acute infection, any form of musculoskeletal injury, orthopedic problems or decompensated cardiovascular disease
* Insulin dependent diabetes
* Participants using metformin

Primary outcomes:
measure: Maximum strength
timeFrame: Pre-Intervention (i.e. 1 to 28 days before the first training session of the exercise intervention) and Post-Intervention (i.e. 1 to 28 days after the last training session of the exercise intervention)
Secondary outcomes:
measure: Glucose control
timeFrame: Pre-Intervention (i.e. 1 to 28 days before the first training session of the exercise intervention) and Post-Intervention (i.e. 1 to 28 days after the last training session of the exercise intervention)
measure: Body composition
timeFrame: Pre-Intervention (i.e. 1 to 28 days before the first training session of the exercise intervention) and Post-Intervention (i.e. 1 to 28 days after the last training session of the exercise intervention)
measure: Cardiorespiratory fitness
timeFrame: Pre-Intervention (i.e. 1 to 28 days before the first training session of the exercise intervention) and Post-Intervention (i.e. 1 to 28 days after the last training session of the exercise intervention)
Other outcomes:
Locations:
city: Basel
country: Switzerland
facility: University of Basel
Study officials:
affiliation: University of Basel
name: Raphael Knaier, PhD
role: PRINCIPAL_INVESTIGATOR
References: