Clinical trial NCT05531396: Agility Training on Physical Performance, Cognitive Function and Brain Activities in Elderly
Official title: The Effects of Agility Training and Its Relations on Physical Performance, Cognitive Function and Brain Activities in Elderly
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Elderly
Healthy
Keywords: Agility training
Physical function
Cognition function
Elderly
Functional near-infrared spectroscopy (fNIRS)
Lead sponsor: National Taiwan University Hospital
Sponsor class: OTHER
First posted: 2022-09-08
Enrollment: 30
Sex: ALL
Minimum age (years): 65
Maximum age (years): 100
Standard ages: OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: Agility comprised of cognitive and physical functions, which influences whole-body movement with change of speed and direction. Agility training is widely used in athletes, and recent studies have begun to apply it into the elderly. Agility training is multidimensional and highly functional, which makes it possible to provide more efficient training in limited time. In elderly, the decrement of cognitive function, muscle strength in the upper and lower limbs, the percentage of body fat, body flexibility and endurance caused by aging will make it difficult for the elderly to perform movements. Therefore, it is essential to explore whether agility training can achieve the improvement of the physical function and cognitive function in elderly, and to find the relationship between the two functions and brain activity. Method: This study will recruit 60 participants, and randomly allocate to control group and agility training. The training groups will have 8 weeks of training, 2 times a week, 45 minutes of training each time. Assessment will be performed before and after intervention in 1-week, and with 1-month follow-up. Assessment including agility ability, physical function, cognitive function, brain activity, and functional assessment scales.


Eligibility criteria: Inclusion Criteria:

1. older than 65 years old
2. score of Mini-Mental State Examination (MMSE) ≥ 24
3. able to walk independently for more than 30 meters without assistive aids
4. able to follow orders

Exclusion Criteria:

1. poorly controlled or unstable systematic disease
2. has a history of central nervous system disease
3. currently taking antidepressants, anti-anxiety, or other psychiatric drugs that may affect blood flow in the brain
4. has other medical conditions for which exercise is contraindicated; (5) subjects with achromatopsia.

Primary outcomes:
measure: Agility Challenge for the Elderly (ACE)
timeFrame: Baseline, 8 weeks, and 12 weeks
Secondary outcomes:
measure: Fall history and fear of falls
timeFrame: Baseline, 8 weeks, and 12 weeks
measure: Quality of life (QOL)
timeFrame: Baseline, 8 weeks, and 12 weeks
measure: Brain activation
timeFrame: Baseline, 8 weeks, and 12 weeks
Other outcomes:
measure: Montreal Cognitive Assessment (MoCA)
timeFrame: Baseline, 8 weeks, and 12 weeks
measure: Working memory
timeFrame: Baseline, 8 weeks, and 12 weeks
measure: Mental set shifting
timeFrame: Baseline, 8 weeks, and 12 weeks
measure: Selective attention and inhibition
timeFrame: Baseline, 8 weeks, and 12 weeks
measure: Motor Function
timeFrame: Baseline, 8 weeks, and 12 weeks
Locations:
Study officials:
affiliation: National Taiwan University
name: Yan Ci Liu, PhD
role: PRINCIPAL_INVESTIGATOR
References: