louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT03999216: Comparing Diuretic Strategies in Hospitalized Heart Failure
Official title: Creating a Platform for Point-of-Care Pragmatic Clinical Trials: Comparing Diuretic Strategies in Heart Failure
Study type: INTERVENTIONAL
Overall status: WITHDRAWN
Phase: PHASE4
Conditions: Heart Failure
Keywords: diuretics
Lead sponsor: Stanford University
Sponsor class: OTHER
Collaborators: name: American Heart Association
First posted: 2019-06-26
Enrollment: 0
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: We will conduct a pragmatic randomized trial comparing whether using a combination of two types of diuretics (loop + thiazide) compared with using a single diuretic (loop only) will result in shorter hospital stays for patients hospitalized with heart failure.


Eligibility criteria: Inclusion Criteria:

Any adult (age ≥18 years) admitted to the Heart Failure Service at Stanford Health Care with an indication for treatment with a diuretic.

Exclusion Criteria:

1. admission to the intensive care unit or cardiac care units
2. maintenance dialysis on admission
3. any mechanical circulatory support on admission
4. history of heart transplant
5. allergy / intolerance to loop or thiazide diuretics
6. admission serum sodium \< 125 meq/L (from EPIC)
7. admission serum potassium \< 3.0 meq/L (from EPIC)

Primary outcomes:
measure: Hospital length of stay
timeFrame: During hospitalization up to 90 days
Secondary outcomes:
measure: Composite of all-cause rehospitalizations, emergency department visits, or death in the 30 days after hospital discharge.
timeFrame: 30 days
Other outcomes:
Locations:
city: Palo Alto
country: United States
facility: Stanford Health Care
state: California
Study officials:
affiliation: Stanford University
name: Tara Chang, MD, MS
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT01984216: Billroth II Versus Roux-en-Y for the Gastrojejunostomy in the Pancreatoduodenectomy
Official title: Billroth II Versus Roux-en-Y for the Gastrojejunostomy Reconstruction in the Pancreatoduodenectomy: a Randomized Controlled Study
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Pancreatoduodenectomy
Lead sponsor: Fundacion Miguel Servet
Sponsor class: OTHER
First posted: 2013-11-14
Enrollment: 64
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL

Brief summary: The purpose of this study is to compare the safety and superiority of Roux-Y versus Billroth II gastrojejunostomy reconstruction on delayed gastric emptying after pancreatoduodenectomy.


Eligibility criteria: Inclusion Criteria:

* Consecutive series of patients undergoing pancreaticoduodenectomy (PD).
* Given informed consent.

Exclusion Criteria:

* Inability to perform pancreatogastrostomy.
* Resection of other organs, except the superior mesenteric-portal vein.
* Previous gastric surgery.
* Preoperative gastric or duodenal obstruction.
* Previous complex abdominal surgery.

Primary outcomes:
measure: Incidence of delayed gastric emptying (DGE)
timeFrame: 30 day after surgery
Secondary outcomes:
Other outcomes:
Locations:
city: Pamplona
country: Spain
facility: Complejo Hospitalario de Navarra
state: Navarre
Study officials:
affiliation: Complejo Hospitalario de Navarra
name: Francisco Javier Herrera, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT03531216: Topical Rosemary Oil Application in Systemic Sclerosis
Official title: Psychophysiological Effect of Local Rosemary and Olive Oil Application Onto the Hands of Patients With Systemic Sclerosis - a Prospective Crossover, Open-label, Nonrandomized Trial
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Systemic Sclerosis
Lead sponsor: ARCIM Institute Academic Research in Complementary and Integrative Medicine
Sponsor class: OTHER
Collaborators: name: University Hospital Tuebingen
First posted: 2018-05-21
Enrollment: 12
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NON_RANDOMIZED
Intervention model: CROSSOVER
Primary purpose: TREATMENT

Brief summary: The objectives of this prospective crossover, open-label, nonrandomized study are to estimate effect sizes of vasodilatation and sense of warmth after application of topical rosemary essential oil in patients suffering from systemic sclerosis.

Detailed description: In a crossover design, patients suffering from systemic sclerosis (12 subjects) receive applications of olive oil and of 10% Rosmarinus officinalis L. (rosemary) essential oil to both hands with a wash-out period of 3 hours. Effects on vasodilatation are measured with infrared thermography. Patients' sense of warmth is assessed by the "Herdecke warmth perception questionnaire". Measurements take place at baseline and 45 minutes following the interventions (pre-post-comparison). To determine within and between-differences, 2-sample t-tests will be used and effect sizes will be calculated (Standardized Effect Size).

Eligibility criteria: Inclusion Criteria:

* Systemic sclerosis with skin involvement of hands and fingers
* Raynaud phenomenon with frequent symptoms of cold hands

Exclusion Criteria:

* Topical treatment with nitroglyceride
* Lymphdrainage \< 24 hours
* Other topical treatment of hands and arms \< 4 hours prior to study intervention

Primary outcomes:
measure: Change from baseline in temperature at the fingers
timeFrame: baseline and 45 minutes after the intervention
Secondary outcomes:
measure: Change from baseline in temperature at the back of the hands
timeFrame: baseline and 45 minutes after the intervention
measure: Change from baseline in temperature at the forearms
timeFrame: baseline and 45 minutes after the intervention
measure: Change from baseline of "Herdecke warmth perception questionnaire" (HeWEF)
timeFrame: baseline and 45 minutes after the intervention
measure: "Scleroderma Health Assessment Questionnaire" (SHAQ)
timeFrame: baseline
measure: Rodnan skin score of the hands
timeFrame: baseline
Other outcomes:
Locations:
city: Filderstadt
country: Germany
facility: ARCIM Institute
state: Baden Württemberg
city: Tuebingen
country: Germany
facility: Universitätsklinikum Tuebingen, Abteilung Innere Medizin II
state: Baden-Württemberg
Study officials:
affiliation: ARCIM Institute; University of Tuebingen
name: Jan Vagedes, Dr.
role: STUDY_DIRECTOR
References:
Clinical trial NCT03250416: Management of Noninvasive Ventilation in Hypoxemic Patients
Official title: The First Affiliated Hospital of Chongqing Medical University
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Noninvasive Ventilation
Lead sponsor: Chongqing Medical University
Sponsor class: OTHER
First posted: 2017-08-15
Enrollment: 2179
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: CASE_ONLY
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: The main population is acute hypoxemic respiratory failure. The subgroup included ARDS, pneumonia, sepsis and so on.

Brief summary: The investigator aimed to manage noninvasive ventilation in patients with hypoxemic respiratory failure.

Detailed description: Patients with hypoxemic respiratory failure were enrolled in this study. The investigator collected the data at beginning and first stage of noninvasive ventilation to analyze the efficacy of noninvasive ventilation. To manage the noninvasive ventilation easily, the investigator also aimed to develop a scale to predict the efficacy of noninvasive ventilation, and used this scale to guide clinicians how to use noninvasive ventilation.

Eligibility criteria: Inclusion Criteria:

* PaO2/FiO2 less than 300; PaCO2 less than 50 mmHg; Respiratory rate more than 25 breaths/min or presence of labored breath.

Exclusion Criteria:

* Requirement of emergency intubation; Sequential use of noninvasive ventilation after extubation;Use of noninvasive ventilation after accident extubation.

Primary outcomes:
measure: Noninvasive ventilation failure
timeFrame: From participation to 30 days
Secondary outcomes:
measure: Mortality
timeFrame: From participation to 30 days
measure: ICU stay
timeFrame: From participation to 30 days
Other outcomes:
Locations:
city: Chongqing
country: China
facility: The First Affiliated Hospital ,Chongqing Medical Univercity
state: Chongqing
Study officials:
affiliation: First Affiliated Hospital of Chongqing Medical University
name: Jun Duan, Dr
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT00623116: A Study to Characterize Epidemiology, Clinical and Genetic Features of Kallmann Syndrome in Finland
Official title: Kallmann Syndrome in Finland
Study type: INTERVENTIONAL
Overall status: ENROLLING_BY_INVITATION
Phase: NA
Conditions: Kallmann Syndrome
Keywords: Kallmann Syndrome
hypogonadotropic hypogonadism
Lead sponsor: Hospital for Children and Adolescents, Finland
Sponsor class: OTHER
First posted: 2008-02-25
Enrollment: 50
Sex: ALL
Minimum age (years): 15
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: TREATMENT

Brief summary: Objective is to characterize epidemiology, clinical and genetic features of Kallmann syndrome in Finland.

Detailed description: Kallmann syndrome is comprised of idiopathic hypogonadotropic hypogonadism and anosmia (inability to smell). Associated phenotypes may include cryptorchidism, microphallus, bone deformations, mirror movements, hearing loss and infertility. Objective is to characterize epidemiology, clinical and genetic features of Kallmann syndrome in Finland.

Eligibility criteria: Inclusion Criteria:

* Kallmann syndrome
* Age 15 yrs or more

Exclusion Criteria:

* Severe mental retardation

Primary outcomes:
measure: Clinical features including quality of life, reversibility and genetic features of Kallmann syndrome in Finland
timeFrame: 0, 3 mo and during subsequent F/U
Secondary outcomes:
measure: epidemiology
timeFrame: by 2012 (anticipated)
Other outcomes:
Locations:
city: Helsinki
country: Finland
facility: Hospital for Children and Adolescents, Helsinki University Central Hospital
Study officials:
affiliation: Hospital for Children and Adolescents, Helsinki University Central Hospital
name: Taneli J Raivio, MD PhD
role: STUDY_DIRECTOR
References:
Clinical trial NCT06729216: Fungal Resistance in Dermatophyte Infection
Official title: Species Identification and Antifungal Susceptibility Testing of Dermatophytes Isolated From Patients Attending Dermatology Outpatient Clinic at Kasr Alainy Hospitals
Study type: OBSERVATIONAL
Overall status: NOT_YET_RECRUITING
Conditions: Dermatophyte Infection
Lead sponsor: Cairo University
Sponsor class: OTHER
First posted: 2024-12-11
Enrollment: 42
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Observational model: CASE_ONLY
Time perspective: CROSS_SECTIONAL
Sampling method: PROBABILITY_SAMPLE
Study population: Patients with dermatophytic skin infection

Brief summary: The aim of the study is to compare the efficiency of broth microdilution versus disk diffusion method for antifungal drug susceptibility testing of the most used drugs in dermatophytosis treatment.


Eligibility criteria: Inclusion Criteria:

* Patients diagnosed clinically with dermatophytosis, any age group and any sex

Exclusion Criteria:

* Patients under either Local or systemic antifungal treatment

Primary outcomes:
measure: Precent susceptibility to each drug
timeFrame: 3 months
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
References:
Clinical trial NCT04278716: Return to Play Checklist
Official title: Safe Return to Play Following Surgery for Labral Repair: Development and Validation of a Return to Play Checklist
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Labral Tear, Glenoid
Lead sponsor: Rothman Institute Orthopaedics
Sponsor class: OTHER
First posted: 2020-02-20
Enrollment: 1000
Sex: ALL
Minimum age (years): 15
Standard ages: CHILD
ADULT
OLDER_ADULT
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: All athletes undergoing arthroscopic capsulolabral repair surgery will be eligible for participation

Brief summary: This study will try to develop and determine objective and validated criteria for our athletes to safely return to sports after labral repair.


Eligibility criteria: Inclusion Criteria:

- Males and non-pregnant females aged 15 years or older with a capsulolabral tear undergoing arthroscopic capsulolabral repair surgery at the Rothman Institute with one of the investigators

Exclusion Criteria:

* Patients with an labral repair
* Patients only undergoing debridements with no repair
* Patients undergoing revision shoulder surgery or those with a history of multiple shoulder surgeries
* Concomitant severe glenohumeral arthritis or adhesive capsulitis
* Patients with a worker's compensation claim
* Patients diagnosed with psychological disorders
* Patients with a history of alcohol or drug abuse -Patients on preoperative narcotic therapy -

Primary outcomes:
measure: Successful completion of the return to play checklist
timeFrame: 1 year post-surgery
Secondary outcomes:
Other outcomes:
Locations:
city: Egg Harbor Township
country: United States
facility: Rothman Orthopaedics at Egg Harbor Township
state: New Jersey
Study officials:
References:
Clinical trial NCT01013116: Evaluation of Efficacy and Safety of Specific Immunotherapy With Modified Allergen Extracts of House Dust Mites
Official title: A Double-blind Placebo-controlled Trial to Evaluate Efficacy and Safety of Specific Subcutaneous Immunotherapy in Patients With Perennial Allergic Rhinitis Due to House Dust Mites
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: PHASE3
Conditions: Allergic Rhinitis
Lead sponsor: Roxall Medizin
Sponsor class: INDUSTRY
First posted: 2009-11-13
Enrollment: 120
Sex: ALL
Minimum age (years): 18
Maximum age (years): 60
Standard ages: ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The objective of this study is to evaluate the efficacy and safety of specific subcutaneous immunotherapy with modified allergen extracts.


Eligibility criteria: Inclusion Criteria:

* Positive history of perennial allergic rhinitis due to house dust mites
* Positive screening skin prick test (wheal diameter \> 3 mm)
* Compliance and ability of the patient to complete a Diary Card for self-evaluating of the symptoms and antisymptomatic medication
* Signed and dated patient´s Informed Consent,

Exclusion Criteria:

* Previous immunotherapy with mite extracts within the last 3 years,
* Simultaneous participation in other clinical trials,
* Other reasons contra-indicating an inclusion into the trial according to the investigator´s estimation (e.g. poor compliance),
* Auto-immune disorders,
* Severe chronic inflammatory diseases,
* Malignancy,
* Alcohol abuse,
* Existing or intended pregnancy, lactation and/or lack of adequate contraceptive protection,
* Treatment with beta-blockers (incl. local application) and/or other contra-indicated drugs.

Primary outcomes:
measure: Symptom and medication score
timeFrame: 1 year
Secondary outcomes:
measure: Safety of the treatment
timeFrame: 1 year
measure: Documentation of adverse events
timeFrame: 1 year
measure: Clinical global improvement
timeFrame: 1 year
measure: Quality of Life Questionnaire
timeFrame: 1 year
Other outcomes:
Locations:
city: Madrid
country: Spain
Study officials:
References:
Clinical trial NCT05960916: Primary Stability of Immediate Implant Using Versah Versus Conventional Burs
Official title: Primary Stability of Immediate Dental Implant Using Osseodensification and Conventional Burs (A Randomized a Clinical Comparative Prospective Study)
Study type: INTERVENTIONAL
Overall status: ACTIVE_NOT_RECRUITING
Phase: NA
Conditions: Edentulous Alveolar Ridge
Lead sponsor: University of Baghdad
Sponsor class: OTHER
First posted: 2023-07-27
Enrollment: 17
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Intervention model description: Dividing two groups according drill type and parallelly measured during study
Primary purpose: SUPPORTIVE_CARE

Brief summary: This study is designed as a Prospective Randomized Clinical Trail, Evaluate the effect of osseodensification technique on primary stability in comparison to the conventional drilling technique in immediate single fresh extraction sockets.

Detailed description: In this study, 30 dental implants inserted immediately after tooth extraction (not a multi-rooted tooth) as a two groups according to bur drill technique and measure the primary stability by osstell devise based on resonance frequency analysis (RFA) value which is scaled from 1-100, after 16 weeks measuring the secondary stability.

Eligibility criteria: Inclusion Criteria:

* Healthy and medically fit patients
* Patients age ≥18 years for both gender
* Apical bone ≥ 2mm from vertical structure showed in x-rays.
* Patient has tooth or teeth with single root anterior and\\or posterior area cannot
* restored by another dental treatment procedure.

Exclusion Criteria:

* Patient with active periodontal disease.
* Pregnancy or lactation.
* A local or systemic disorder that is contraindicated for the minor surgical procedure
* and may affect healing process.
* Any irradiation in head and neck area.
* Heavy smoking habit.

Primary outcomes:
measure: Primary Implant Stability Quotient (ISQ)
timeFrame: baseline value of implant stability measured immediately after implant installation (primary stability)
Secondary outcomes:
measure: Secondary Implant Stability Quotient (ISQ)
timeFrame: Changes in implant stability after 16 weeks (secondary stability) from baseline value measured immediately after implant placement (primary stability)
Other outcomes:
Locations:
city: Baghdad
country: Iraq
facility: Mustafa Thamir Naji
Study officials:
affiliation: University of Baghdad
name: Hasanain A. Al-Jumaily, C.A.B.M.S
role: STUDY_DIRECTOR
References:
Clinical trial NCT02674516: The Effect of Repeated Prefrontal Cortex Stimulation on Antisocial and Aggressive Behavior
Official title: The Effect of Repeated Transcranial Direct Current Stimulation of the Prefrontal Cortex on Antisocial and Aggressive Behavior
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Antisocial Behavior
Aggression
Keywords: antisocial behavior
aggression
transcranial direct current stimulation
dorsolateral prefrontal cortex
associated risk factors
Lead sponsor: University of Pennsylvania
Sponsor class: OTHER
First posted: 2016-02-04
Enrollment: 32
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: BASIC_SCIENCE

Brief summary: This study investigates the relationship between prefrontal cortex activity and antisocial and aggressive behavior, and risk factors for such behavior. In the double-blind, randomized controlled trial, participants will undergo three sessions of anodal transcranial direct current stimulation of the dorsolateral prefrontal cortex or sham stimulation and complete survey and laboratory measures assessing antisocial behavior and risk factors. Heart rate and skin conductance will also be measured.


Eligibility criteria: Inclusion Criteria:

* Above 18 years of age
* Able to understand the nature of the study and give informed consent

Exclusion Criteria:

* Currently consuming anti-convulsant, anti-psychotic, or sedative/hypnotic medications
* Currently consuming anti-depressants
* History of seizures
* Metallic implants on the scalp
* Participation in other transcranial magnetic stimulation (TMS) or tDCS experiments on the same day
* History of adverse reactions to tDCS

Primary outcomes:
measure: Number of Pins Inserted Into a Virtual Voodoo Doll After 48 Hours
timeFrame: On average, 48 hours after the first 20-minute tDCS or sham session ends
Secondary outcomes:
Other outcomes:
Locations:
city: Philadelphia
country: United States
facility: University of Pennsylvania
state: Pennsylvania
Study officials:
affiliation: University of Pennsylvania
name: Adrian Raine, DPhil
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT06787716: Impact of Whole-body Vibration Training on Muscle Flexibility and Fatigue After Lower Extremity Thermal Burn Injury
Official title: Impact of Whole-body Vibration Training on Muscle Flexibility and Fatigue After Lower Extremity Thermal Burn Injury
Study type: INTERVENTIONAL
Overall status: RECRUITING
Phase: EARLY_PHASE1
Conditions: Lower Extremity Burns
Keywords: burn
flexibility
muscle fatigue
EMG
Lead sponsor: Cairo University
Sponsor class: OTHER
First posted: 2025-01-22
Enrollment: 80
Sex: ALL
Minimum age (years): 20
Maximum age (years): 50
Standard ages: ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: OTHER

Brief summary: Tight hamstring muscles limit the anterior tilt of the pelvis in spinal flexion resulting in aggravated muscle and ligamentous tension in the lumbar region which leads to significantly higher compressive loads on the lumbar spine. Other postural changes associated with tightness of the hamstrings can influence the sacroiliac joint stability in an indirect way. Hence, flexibility of hamstring muscles is crucial for overall well-being and optimal physical fitness.


Eligibility criteria: Inclusion criteria:

1. Patients with a deep second-degree thermal burn of the lower extremity, 35%-40% total body surface area (TBSA) of burn as measured with the rule of nine, after six weeks from the injury or complete wound healing.
2. Patients with 20 to 50 years old.
3. Absence of any neurological disorder i.e.: stroke, ataxia, or parkinsonism.

Exclusion criteria:

1. Patients with open wounds.
2. Patients with recent fractures.
3. Patients with severe obesity BMI ≥40.
4. Patients with cardiorespiratory disorders.
5. Patients with bone disease, joint replacement, and traumatic spine history since last year.

In order to apply the inclusion and exclusion criteria, all cases will be subjected to an interview and assessment.

Those subjects who will be eligible to take part in the study will sign an informed consent before participation in the study.

Primary outcomes:
measure: Active Knee Extension Test:
timeFrame: 12 weeks
Secondary outcomes:
measure: Straight Leg Raising Test
timeFrame: 12 weeks
measure: Electromyography for Quadriceps Muscle
timeFrame: 12 weeks
measure: Electromyography for Hamstring Muscles
timeFrame: 12 weeks
Other outcomes:
Locations:
city: Cairo
country: Egypt
facility: Faculty of Physical Therapy, Cairo University
state: Giza
Study officials:
References: