Clinical trial NCT04746924: A Study of Ociperlimab With Tislelizumab Compared to Pembrolizumab in Participants With Untreated Lung Cancer
Official title: A Phase 3, Randomized, Double-Blind Study of Ociperlimab, an Anti-TIGIT Antibody, in Combination With Tislelizumab Compared to Pembrolizumab in Patients With Previously Untreated, PD-L1-Selected, and Locally Advanced, Unresectable, or Metastatic Non-Small Cell Lung Cancer
Study type: INTERVENTIONAL
Overall status: ACTIVE_NOT_RECRUITING
Phase: PHASE3
Conditions: Non-small Cell Lung Cancer
NSCLC
Keywords: Locally Advanced
Unresectable
Metastatic
Tislelizumab
BGB-A317
Ociperlimab
BGB-A1217
Pembrolizumab
Anti-TIGIT
Lead sponsor: BeiGene
Sponsor class: INDUSTRY
First posted: 2021-02-10
Enrollment: 662
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The purpose of this study is to evaluate the efficacy and safety of ociperlimab + tislelizumab compared with that of pembrolizumab in adults with PD-L1 high, locally advanced/recurrent or untreated metastatic NSCLC.


Eligibility criteria: Key Inclusion Criteria:

1. Histologically or cytologically documented locally advanced or recurrent non-small cell lung cancer (NSCLC) that is not eligible for curative surgery and/or definitive radiotherapy with or without chemoradiotherapy, or metastatic-nonsquamous or squamous NSCLC.
2. No prior systemic treatment for metastatic NSCLC.
3. Agreement to provide archival tissue or fresh biopsy (if archival tissue is not available).
4. Tumors with PD-L1 expressed in ≥ 50% tumor cells.
5. At least 1 measurable lesion as defined per RECIST v1.1.
6. ECOG Performance Status ≤ 1.

Key Exclusion Criteria:

1. Known mutations in the epidermal growth factor receptor (EGFR) gene, anaplastic lymphoma kinase (ALK) fusion oncogene, BRAF V600E, or ROS1.
2. Prior therapy with an anti-programmed cell death protein (anti-PD)-1, anti-PD-ligand (L)-1, anti-PD-ligand-2, anti-T-cell immunoglobulin and ITIM (anti-TIGIT) domain, or any other antibody or drug specifically targeting T-cell costimulation or checkpoint pathways.
3. Active leptomeningeal disease or uncontrolled, untreated brain metastasis.
4. Active autoimmune diseases or history of autoimmune diseases that may relapse.

Note: Other protocol defined Inclusion/Exclusion criteria may apply

Primary outcomes:
measure: Overall Survival (OS)
timeFrame: Up to approximately 58 months
Secondary outcomes:
measure: Progression-free Survival (PFS) As Assessed By Investigators
timeFrame: Up to approximately 58 months
measure: Overall Response Rate (ORR) As Assessed By Investigators
timeFrame: Up to approximately 58 months
measure: Duration Of Response (DOR) As Assessed By Investigators
timeFrame: Up to approximately 58 months
measure: Health-related Quality Of Life (HRQoL): European Organization For Research And Treatment Of Cancer Quality Of Life Questionnaire Core 30 (EORTC QLQ-C30)
timeFrame: Within 7 days after permanent treatment discontinuation
measure: HRQoL: EORTC Lung Cancer Module Quality of Life Questionnaire Lung Cancer 13 (QLQ-LC13) HRQoL will be assessed via PRO using the EORTC QLQ-LC13.
timeFrame: Within 7 days after permanent treatment discontinuation
measure: HRQoL: European Quality of Life-5 Level- 5 Dimension (EQ-5D-5L) Questionnaire
timeFrame: Within 7 days after permanent treatment discontinuation
measure: Time To Deterioration (TTD)
timeFrame: Within 7 days after permanent treatment discontinuation
measure: Number Of Participants Experiencing Adverse Events (AEs)
timeFrame: 90 days (±14) after last dose
Other outcomes:
Locations:
city: Fullerton
country: United States
facility: Providence Medical Foundation St Jude Heritage Healthcare
state: California
city: Los Angeles
country: United States
facility: Valkyrie Clinical Trials
state: California
city: Ocala
country: United States
facility: Ocala Oncology Center Pl Dba Florida Cancer Affiliates Ocala
state: Florida
city: Orlando
country: United States
facility: Advent Health Cancer Institute
state: Florida
city: Goshen
country: United States
facility: Goshen Center For Cancer Care
state: Indiana
city: Lexington
country: United States
facility: Baptist Health Lexington
state: Kentucky
city: New Orleans
country: United States
facility: University Medical Center New Orleans West Jefferson Medical Center
state: Louisiana
city: Saint Paul
country: United States
facility: Metro Minnesota Community Oncology Research Consortium (Mmcorc)
state: Minnesota
city: Pittsburgh
country: United States
facility: West Penn Hospital
state: Pennsylvania
city: Buenos Aires
country: Argentina
facility: Centro Medical Austral
city: Tucuman
country: Argentina
facility: Centro Para La Atencion Del Paciente Oncologico (Caipo)
city: Concord
country: Australia
facility: Concord Repatriation General Hospital
state: New South Wales
city: St Leonards
country: Australia
facility: Northern Cancer Institute
state: New South Wales
city: Waratah
country: Australia
facility: Calvary Mater Newcastle
state: New South Wales
city: Benowa
country: Australia
facility: Pindara Private Hospital
state: Queensland
city: Chermside
country: Australia
facility: The Prince Charles Hospital
state: Queensland
city: South Brisbane
country: Australia
facility: Mater Cancer Care Centre
state: Queensland
city: Tugun
country: Australia
facility: John Flynn Private Hospital
state: Queensland
city: Elizabeth Vale
country: Australia
facility: Lyell McEwin Hospital
state: South Australia
city: Ballarat
country: Australia
facility: Ballarat Health Services
state: Victoria
city: Clayton
country: Australia
facility: Monash Health
state: Victoria
city: St Albans
country: Australia
facility: Western Health Sunshine Hospital
state: Victoria
city: Murdoch
country: Australia
facility: St John of God, Murdoch
state: Western Australia
city: Brasilia
country: Brazil
facility: Instituto Dor de Pesquisa E Ensino Distrito Federal
city: Cachoeiro de Itapemirim
country: Brazil
facility: Hospital Evangelico de Cachoeiro de Itapemirim
city: Florianopolis
country: Brazil
facility: Centro de Pesquisas Oncologicas Cepon
city: Fortaleza
country: Brazil
facility: Cancer Institute of Ceara
city: Santo Andre
country: Brazil
facility: Cepho Centro de Estudos E Pesquisas de Hematologia E Oncologia
city: Sao Jose do Rio Preto
country: Brazil
facility: Fundacao Faculdade Regional de Medicina de Sao Jose Do Rio Preto
city: Hefei
country: China
facility: Anhui Provincial Hospital
state: Anhui
city: Hefei
country: China
facility: The Second Hospital of Anhui Medical University
state: Anhui
city: Beijing
country: China
facility: Beijing Chao Yang Hospital
state: Beijing
city: Beijing
country: China
facility: Beijing Cancer Hospital
state: Beijing
city: Beijing
country: China
facility: Peking Union Medical College Hospital
state: Beijing
city: Beijing
country: China
facility: Beijing Chest Hospital, Capital Medical University
state: Beijing
city: Chongqing
country: China
facility: Chongqing Cancer Hospital
state: Chongqing
city: Chongqing
country: China
facility: The First Affiliated Hospital of Army Military Medical University
state: Chongqing
city: Chongqing
country: China
facility: Daping Hospital, Third Military Medical University
state: Chongqing
city: Chongqing
country: China
facility: Chongqing University Three Gorges Central Hospital
state: Chongqing
city: Fuzhou
country: China
facility: Fujian Medical University Union Hospital
state: Fujian
city: Fuzhou
country: China
facility: Fujian Cancer Hospital
state: Fujian
city: Xiamen
country: China
facility: The First Affiliated Hospital of Xiamen University
state: Fujian
city: Guangzhou
country: China
facility: Affiliated Cancer Hospital and Institute of Guangzhou Medical University
state: Guangdong
city: Shantou
country: China
facility: Cancer Hospital of Shantou University Medical College
state: Guangdong
city: Shenzhen
country: China
facility: Shenzhen Peoples Hospital
state: Guangdong
city: Nanning
country: China
facility: The Peoples Hospital of Guangxi Zhuang Autonomous Region
state: Guangxi
city: Nanning
country: China
facility: The Tumor Hospital Affiliated to Guangxi Medical University
state: Guangxi
city: Harbin
country: China
facility: Harbin Medical University Cancer Hospital
state: Heilongjiang
city: Zhengzhou
country: China
facility: Henan Cancer Hospital
state: Henan
city: Zhengzhou
country: China
facility: The First Affiliated Hospital of Zhengzhou University
state: Henan
city: Wuhan
country: China
facility: Union Hospital of Tongji Medical College, Huazhong University of Science and Technology
state: Hubei
city: Wuhan
country: China
facility: Renmin Hospital of Wuhan University
state: Hubei
city: Wuhan
country: China
facility: Hubei Cancer Hospital
state: Hubei
city: Changsha
country: China
facility: The Second Xiangya Hospital of Central South University
state: Hunan
city: Changsha
country: China
facility: Hunan Cancer Hospital
state: Hunan
city: Changzhou
country: China
facility: Changzhou No Peoples Hospital, the Affiliated Hospital of Nanjing Medical University Branch Cheng
state: Jiangsu
city: Nanjing
country: China
facility: Nanjing First Hospital
state: Jiangsu
city: Nanjing
country: China
facility: Nanjing Chest Hospital
state: Jiangsu
city: Suzhou
country: China
facility: The Second Affiliated Hospital of Soochow University
state: Jiangsu
city: Suzhou
country: China
facility: The First Affiliated Hospital of Soochow University Branch Shizi
state: Jiangsu
city: Xuzhou
country: China
facility: Xuzhou Central Hospital
state: Jiangsu
city: Shenyang
country: China
facility: Liaoning Cancer Hospital and Institute
state: Liaoning
city: Xian
country: China
facility: The First Affiliated Hospital of Xian Jiaotong University
state: Shaanxi
city: Qingdao
country: China
facility: The Affiliated Hospital of Qingdao University Branch Laoshan
state: Shandong
city: Weifang
country: China
facility: Weifang Peoples Hospital
state: Shandong
city: Yantai
country: China
facility: Yantai Yuhuangding Hospital
state: Shandong
city: Shanghai
country: China
facility: Shanghai Chest Hospital
state: Shanghai
city: Shanghai
country: China
facility: Affiliated Zhongshan Hospital of Fudan University
state: Shanghai
city: Shanghai
country: China
facility: Shanghai Pulmonary Hospital
state: Shanghai
city: Taiyuan
country: China
facility: Shanxi Bethune Hospital
state: Shanxi
city: Chengdu
country: China
facility: Sichuan Cancer Hospital and Institute
state: Sichuan
city: Chengdu
country: China
facility: West China Hospital, Sichuan University
state: Sichuan
city: Nanchong
country: China
facility: Affiliated Hospital of North Sichuan Medical College
state: Sichuan
city: Tianjin
country: China
facility: Tianjin Medical University General Hospital
state: Tianjin
city: Tianjin
country: China
facility: Tianjin Medical University Cancer Institute and Hospital
state: Tianjin
city: Urumqi
country: China
facility: Affiliated Cancer Hospital of Xinjiang Medical University
state: Xinjiang
city: Hangzhou
country: China
facility: Sir Run Run Shaw Hospital, Zhejiang University School of Medicine
state: Zhejiang
city: Hangzhou
country: China
facility: Zhejiang Cancer Hospital
state: Zhejiang
city: Ningbo
country: China
facility: The First Affiliated Hospital of Ningbo University
state: Zhejiang
city: Taizhou
country: China
facility: Taizhou Hospital of Zhejiang
state: Zhejiang
city: Yiwu
country: China
facility: The Fourth Affiliated Hospital Zhejiang University School of Medicine
state: Zhejiang
city: Bayonne
country: France
facility: Centre Hospitalier de La Cote Basque Saint Leon Service de Pneumologie
city: Bordeaux
country: France
facility: Centre de Lutte Contre Le Cancer Institut Bergonie
city: Lyon
country: France
facility: Hopital de La Croix Rousse
city: Lyon
country: France
facility: Hopital Louis Pradel
city: Montpellier
country: France
facility: Icm Val Daurelle Oncologie Medicale
city: Nancy
country: France
facility: Polyclinique de Gentilly
city: Paris cedex
country: France
facility: Hopital Cochin
city: PierreBenite
country: France
facility: Chu Hopital Lyon Sud
city: saint Mande
country: France
facility: Hia Begin
city: Saint Pierre
country: France
facility: Chu de La Reunion
city: SaintHerblain
country: France
facility: Centre de Lutte Contre Le Cancer Institut de Cancerologie de Louest Rene Gauducheau
city: SaintHerblain
country: France
facility: Chu Nantes Hopital Nord Laennec
city: Tours
country: France
facility: Chu Tours Hopital Bretonneau Service Pneumologie
city: Batumi
country: Georgia
facility: High Technology Hospital Medcenter Ltd
city: Tbilisi
country: Georgia
facility: Acad Fridon Todua Medical Center Ltd Research Institute of Clinical Medicine Ltd
city: Tbilisi
country: Georgia
facility: Israel Georgian Medical Research Clinic Helsicore Ltd
city: Tbilisi
country: Georgia
facility: Jsc German Hospital
city: Tbilisi
country: Georgia
facility: Institute of Clinical Oncology Ltd
city: Tbilisi
country: Georgia
facility: Jsc Evex Hospitals Tbilisi
city: Tbilisi
country: Georgia
facility: Tim Tbilisi Institute of Medicine Ltd
city: Tbilisi
country: Georgia
facility: Caucasus Medical Centre Ltd
city: Tbilisi
country: Georgia
facility: Multiprofile Clinic Consilium Medulla Ltd
city: Tbilisi
country: Georgia
facility: Oncology Research Center Ltd
city: Aachen
country: Germany
facility: Universitaetsklinikum Aachen
city: Bonn
country: Germany
facility: Universitatsklinikum Bonn
city: Giessen
country: Germany
facility: Uniklinikum Giessen Marburg
city: Grohansdorf
country: Germany
facility: Lungenclinic Grosshansdorf Gmbh
city: Hamburg
country: Germany
facility: Ambulantes Krebszentrum Hamburg
city: Koln
country: Germany
facility: Kliniken Der Stadt Koeln Ggmbh
city: Munich
country: Germany
facility: Munchen Klinik Bogenhausen
city: Rotenburg
country: Germany
facility: Agaplesion Diakonieklinikum Rotenburg Gemeinnutzige Gmbh
city: Bologna
country: Italy
facility: Azienda Ospedaliera Universitaria Policlinico Santorsola Malpighi
city: Messina
country: Italy
facility: Azienda Ospedaliera Papardo
city: Orbassano
country: Italy
facility: Aou San Luigi Gonzaga
city: Nagoya
country: Japan
facility: Nagoya University Hospital
state: Aichi
city: Hirosaki
country: Japan
facility: Hirosaki University Hospital
state: Aomori
city: Matsuyamashi
country: Japan
facility: Nho Shikoku Cancer Center
state: Ehime
city: Kurume
country: Japan
facility: Kurume University Hospital
state: Fukuoka
city: Shibukawa
country: Japan
facility: National Hospital Organization Shibukawa Medical Center
state: Gunma
city: Kobe
country: Japan
facility: Kobe University Hospital
state: Hyogo
city: Kobe
country: Japan
facility: Kobe City Medical Center General Hospital
state: Hyogo
city: Nishinomiyashi
country: Japan
facility: Hyogo Medical University Hospital
state: Hyogo
city: Kanazawa
country: Japan
facility: Kanazawa University Hospital
state: Ishikawa
city: Yokohamashi
country: Japan
facility: Kanagawa Cancer Center
state: Kanagawa
city: Natorishi
country: Japan
facility: Miyagi Cancer Center
state: Miyagi
city: Okayamashi
country: Japan
facility: Okayama University Hospital
state: Okayama
city: Hirakata
country: Japan
facility: Kansai Medical University Hospital
state: Osaka
city: Osakasayama
country: Japan
facility: Kindai University Hospital
state: Osaka
city: Sakai
country: Japan
facility: National Hospital Organization Kinki Chuo Chest Medical Center
state: Osaka
city: Toyonaka
country: Japan
facility: Osaka Toneyama Medical Center
state: Osaka
city: Shimonotsuke
country: Japan
facility: Jichi Medical University Hospital
state: Tochigi
city: Shimotsugagun
country: Japan
facility: Dokkyo Medical University Hospital
state: Tochigi
city: Utsunomiya
country: Japan
facility: Tochigi Cancer Center
state: Tochigi
city: Bunkyoku
country: Japan
facility: Nippon Medical School Hospital
state: Tokyo
city: Kotoku
country: Japan
facility: Cancer Institute Hospital of Jfcr
state: Tokyo
city: Hiroshima
country: Japan
facility: Hiroshima University Hospital
city: Niigata
country: Japan
facility: Niigata Cancer Center Hospital
city: Cheongjusi
country: Korea, Republic of
facility: Chungbuk National University Hospital
state: Chungcheongbukdo
city: Dalseogu
country: Korea, Republic of
facility: Keimyung University Dongsan Hospital
state: Daegu Gwang'yeogsi
city: BucheonSi
country: Korea, Republic of
facility: The Catholic University of Korea Bucheon St Marys Hospital
state: Gyeonggi-do
city: Gyeonggido
country: Korea, Republic of
facility: Cha Bundang Medical Center, Cha University
state: Gyeonggi-do
city: Suwonsi
country: Korea, Republic of
facility: The Catholic University of Korea, St Vincents Hospital
state: Gyeonggi-do
city: Daegu
country: Korea, Republic of
facility: Kyungpook National University Chilgok Hospital
state: Gyeongsangbukdo
city: Eunpyeonggu
country: Korea, Republic of
facility: The Catholic University of Korea, Eunpyeong St Marys Hospital
state: Seoul Teugbyeolsi
city: Seoul
country: Korea, Republic of
facility: Severance Hospital Yonsei University Health System
state: Seoul Teugbyeolsi
city: Amersfoort
country: Netherlands
facility: Meander Medisch Centrum
city: Arnhem
country: Netherlands
facility: Rijnstate
city: Harderwijk
country: Netherlands
facility: Ziekenhuis St Jansdal
city: Heerlen
country: Netherlands
facility: Stichting Zuyderland Medisch Centrum
city: Zwolle
country: Netherlands
facility: Isala Klinieken Zwolle
city: Bialystok
country: Poland
facility: Uniwersytecki Szpital Kliniczny W Bialymstoku
city: Lodz
country: Poland
facility: Centrum Terapii Wspoczesnej
city: Lodz
country: Poland
facility: Wielospecjalistyczne Centrum Onkologii I Traumatologii Im M Kopernika W Lodzi
city: Poznan
country: Poland
facility: Wielkopolskie Centrum Pulmonologii I Torakochirurgii
city: Poznan
country: Poland
facility: Przychodnia Med Polonia Sp Z Oo
city: Zamosc
country: Poland
facility: Etg Zamosc
city: Arkhangelsk
country: Russian Federation
facility: Arkhangelsk Regional Clinical Oncological Dispensary
state: Arkhangel'skaya Oblast'
city: Ufa
country: Russian Federation
facility: State Autonomous Healthcare Institution Republican Clinical Oncological Dispensary of the Republic
state: Bashkortostan, Respublika
city: Magnitogorsk
country: Russian Federation
facility: State Budgetary Healthcare Institution Regional Oncology Dispensary Number
state: Chelyabinskaya Oblast'
city: Moscow
country: Russian Federation
facility: Vitamed Llc
state: Moskva
city: Nizhny Novgorod
country: Russian Federation
facility: State Budgetary Healthcare Institution Nizhny Novgorod Regional Clinical Oncology Dispensary
state: Nizhegorodskaya Oblast'
city: Omsk
country: Russian Federation
facility: Bih of Omsk Region Clinical Oncology Dispensary
state: Omskaya Oblast'
city: Samara
country: Russian Federation
facility: State Budgetary Healthcare Institution Samara Regional Clinical Oncology Dispensary
state: Samaraskaya Oblast'
city: Saint Petersburg
country: Russian Federation
facility: Llc Av Medical Group
state: Sankt-Peterburg
city: Alcorcon
country: Spain
facility: Hospital Universitario Fundacion Alcorcon
city: Barcelona
country: Spain
facility: Hospital Del Mar
city: Barcelona
country: Spain
facility: Hospital de La Santa Creu I Sant Pau
city: Barcelona
country: Spain
facility: Hospital Universitario Vall Dhebron
city: Barcelona
country: Spain
facility: Hospital Universitari Quiron Dexeus
city: Elche
country: Spain
facility: Hospital General Universitario de Elche
city: Girona
country: Spain
facility: Ico Girona
city: Jaen
country: Spain
facility: Hospital Universitario de Jaen
city: Las Palmas
country: Spain
facility: Complejo Hospitalario Universitario Insular Gran Canaria
city: Lugo
country: Spain
facility: Hospital Universitario Lucus Augusti
city: Madrid
country: Spain
facility: Hospital Clinico San Carlos
city: Madrid
country: Spain
facility: Start Madrid Fundacion Jimenez Diaz
city: Madrid
country: Spain
facility: Hospital Universitario Doce de Octubre
city: Madrid
country: Spain
facility: Hospital Universitario La Paz
city: Majadahonda
country: Spain
facility: Hospital Universitario Puerta de Hierro Majadahonda
city: Malaga
country: Spain
facility: Hospital Regional Universitario de Malaga
city: Malaga
country: Spain
facility: Hospital Universitario Virgen de La Victoria
city: Murcia
country: Spain
facility: Hospital General Universitario Morales Meseguer
city: Orense
country: Spain
facility: Complexo Hospitalario Universitario de Ourense
city: Palma de Mallorca
country: Spain
facility: Hospital Universitari Son Espases
city: Sevilla
country: Spain
facility: Hospital Universitario Virgen Del Rocio
city: Sevilla
country: Spain
facility: Hospital Universitario Nuestra Senora de Valme
city: Valencia
country: Spain
facility: Hospital Arnau de Vilanova
city: Valencia
country: Spain
facility: Hospital Universitari I Politecnic La Fe
city: Changhua
country: Taiwan
facility: Changhua Christian Hospital
city: Kaohsiung
country: Taiwan
facility: Kaohsiung Chang Gung Memorial Hospital
city: Taichung
country: Taiwan
facility: Chung Shan Medical University Hospital
city: Taipei
country: Taiwan
facility: Taipei Veterans General Hospital
city: Taipei
country: Taiwan
facility: Taipei Tzu Chi Hospital
city: Taoyuan
country: Taiwan
facility: Linkou Chang Gung Memorial Hospital
city: Yunlin
country: Taiwan
facility: National Taiwan University Hospital Yunlin Branch
city: Bangkok
country: Thailand
facility: Siriraj Hospital
city: Hat Yai
country: Thailand
facility: Songklanagarind Hospital (Prince of Songkhla University)
city: Lak Si
country: Thailand
facility: Chulabhorn Research Institute
city: Muang
country: Thailand
facility: Srinagarind Hospital (Khon Kaen University)
city: Muang
country: Thailand
facility: Maharaj Nakorn Chiang Mai Hospital (Chiang Mai University)
city: Ratchathewi
country: Thailand
facility: Phramongkutklao Hospital
city: Ratchathewi
country: Thailand
facility: Rajavithi Hospital
city: Adana
country: Turkey
facility: Acibadem Adana Hospital
city: Adana
country: Turkey
facility: Baskent University Practice and Research Hospital Adana Medical Oncology Department
city: Ankara
country: Turkey
facility: Dr Abdurrahman Yurtaslan Ankara Oncology Training and Research Hospital
city: Ankara
country: Turkey
facility: Memorial Ankara Hospital
city: Battalgazi
country: Turkey
facility: Inonu Universitesi Tip Fakultesi
city: Edirne
country: Turkey
facility: Tr Trakya University Health Research and Application Center (Hospital)
city: Istanbul
country: Turkey
facility: Iu C, Clinical Research Excellence Application and Research Center
city: Istanbul
country: Turkey
facility: Tr Ministry of Health Goztepe Prof Dr Suleyman Yalcin City Hospital
city: Izmir
country: Turkey
facility: Ege University Medical Faculty
city: Kocaeli
country: Turkey
facility: Kocaeli Universitesi Tip Fakultesi
city: Meram
country: Turkey
facility: Necmettin Erbakan University Selcuklu Faculty of Medicine
city: Mersin City Hospital
country: Turkey
facility: Mersin City Hospital
city: Kryvyi Rih
country: Ukraine
facility: Medical Center of Limited Liability Company Mriya Med Service
city: Uzhgorod
country: Ukraine
facility: Zakarpatska Regional Clinical Oncological Center
city: Uzhhorod
country: Ukraine
facility: Communal Non Profit Enterprisecentral Municipal Clinical Hospital of Uzhhorod City Council
Study officials:
References: