Clinical trial NCT05403931: The Effectiveness of Low Level Laser Therapy on Particular Joint Points and Acupuncture Points on Knee Joints in Grade III Knee Osteoarthritis
Official title: The Effectiveness of Low Level Laser Therapy on Particular Joint Points and Acupuncture Points on Knee Joints in Grade III Knee Osteoarthritis
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Knee Osteoarthritis
Lead sponsor: Universiti Teknologi Malaysia
Sponsor class: OTHER
First posted: 2022-06-03
Enrollment: 50
Sex: ALL
Minimum age (years): 35
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Intervention model description: Interventional study to compare the effectiveness of low level laser therapy on two groups of points of irradiation in knee OA grade III. One group of points involves 6-7 particular points on tibiofemoral and patellofemoral joints. Other group involves the 6-7 particular acupuncture points which have been previously used in a study. Outcomes will indicate that which group irradiation will produce better therapeutic results.
Primary purpose: TREATMENT

Brief summary: LLLT is in use to treat different musculoskeletal condition. Osteoarthritis is one of the conditions needing LLLT for therapeutic effects. LLLT has been used in different previous studies using different points on joint and also on acupuncture points. This study is going to compare the effectiveness of LLLT on both points. Omega xp device is going to be used in this study.

Detailed description: LLLT is a non-invasive modality to treat variety of musculoskeletal conditions. Photobiomodulation has been studies for last two decades in different perspectives and on different musculoskeletal condition. Studies suggest profound results due to effect of LLLT at the cellular level. Osteoarthritis is one of the most common debilitating musculoskeletal condition affecting people worldwide. Statistics indicate an increase in this debilitating condition in future. Knee OA is more common amongst other OA of the body. LLLT has been used in previous studies to see the impact on pain and functional performance in knee OA. LLLT has been used on different points on knee joint and also applied on acupuncture points of the knee joints. Different outcomes were used to assess LLLT effectiveness including pain, ROM and even different biomarkers. This study is going to use LLLT on different particular joint points of knee and also acupuncture points of the knee joint and compare the outcomes. This study will present evidence for the clinicians to use LLLT on either the particular joint points or acupuncture points for better clinical outcomes.

Eligibility criteria: * Inclusion Criteria:

  * Pain in the knee joint ( minimum 30/100 on VAS )
  * Kellgren-Lawrence Grade III knee OA
  * ACR criteria for knee OA with radiological findings including ;

    * age 35 and above
    * joint crepitus
    * less than 30 minutes of morning stiffness
* Exclusion Criteria:

  * Knee OA grade other than III.
  * Any contraindication of LLLT including;

    * pregnancy
    * carcinoma involving knee area
  * Steroids and NSAIDS use

Primary outcomes:
measure: Western Ontario and McMaster University Osteoarthritis Index ( WOMAC )
timeFrame: Baseline
measure: Western Ontario and McMaster University Osteoarthritis Index ( WOMAC )
timeFrame: 2nd week
measure: Western Ontario and McMaster University Osteoarthritis Index ( WOMAC )
timeFrame: 3rd week
measure: Western Ontario and McMaster University Osteoarthritis Index ( WOMAC )
timeFrame: 4th week
measure: Western Ontario and McMaster University Osteoarthritis Index ( WOMAC )
timeFrame: 16th week
measure: Timed Up and Go test ( TUG )
timeFrame: Baseline
measure: Timed Up and Go test ( TUG )
timeFrame: 2nd week
measure: Timed Up and Go test ( TUG )
timeFrame: 3rd week
measure: Timed Up and Go test ( TUG )
timeFrame: 4th week
measure: Timed Up and Go test ( TUG )
timeFrame: 16th week
measure: Visual Analog Scale ( VAS )
timeFrame: Baseline
measure: Visual Analog Scale ( VAS )
timeFrame: 2nd week
measure: Visual Analog Scale ( VAS )
timeFrame: 3rd week
measure: Visual Analog Scale ( VAS )
timeFrame: 4th week
measure: Visual Analog Scale ( VAS )
timeFrame: 16th week
Secondary outcomes:
Other outcomes:
Locations:
city: Lahore
country: Pakistan
facility: Central Park Teaching Hospital
state: Punjab
Study officials:
affiliation: University of Technology Malaysia
name: Adnan Afzal, PhD
role: PRINCIPAL_INVESTIGATOR
References:
citation: Hegedus B, Viharos L, Gervain M, Galfi M. The effect of low-level laser in knee osteoarthritis: a double-blind, randomized, placebo-controlled trial. Photomed Laser Surg. 2009 Aug;27(4):577-84. doi: 10.1089/pho.2008.2297.
citation: Bjordal JM, Couppe C, Chow RT, Tuner J, Ljunggren EA. A systematic review of low level laser therapy with location-specific doses for pain from chronic joint disorders. Aust J Physiother. 2003;49(2):107-16. doi: 10.1016/s0004-9514(14)60127-6.
citation: Al Rashoud AS, Abboud RJ, Wang W, Wigderowitz C. Efficacy of low-level laser therapy applied at acupuncture points in knee osteoarthritis: a randomised double-blind comparative trial. Physiotherapy. 2014 Sep;100(3):242-8. doi: 10.1016/j.physio.2013.09.007. Epub 2013 Nov 15.