Clinical trial NCT01077258: Efficacy and Safety of Adalimumab in Patients With Rheumatoid Arthritis in Routine Clinical Practice
Official title: Effectiveness and Safety of Adalimumab in Patients With Rheumatoid Arthritis in Routine Clinical Practice
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Rheumatoid Arthritis
Keywords: Safety
Long-term observation
Routine Clinical Setting
Rheumatoid Arthritis
Effectiveness
Lead sponsor: AbbVie
Sponsor class: INDUSTRY
First posted: 2010-03-01
Enrollment: 4208
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: CASE_ONLY
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Community sample: patients with rheumatoid arthritis who resided in Germany. German regulations state that all patients are eligible for non-interventional studies; there are no exclusions. Adult patients (≥ 18 years of age) with RA who were preparing to initiate adalimumab therapy according to the product label were eligible for study enrollment. The eligibility criteria below reflect the approved label as stated in the German Summary of Product Characteristics (SPC) for Humira.

Brief summary: Observation of safety, tolerability and effectiveness of adalimumab (Humira) therapy in a large patient collective under everyday clinical conditions over 2 years.

Detailed description: Patients with rheumatoid arthritis who started treatment with adalimumab in a normal clinical setting according to the product label were documented. The follow-up observation period was for 2 years and focused on safety information and maintenance of efficacy during a normal clinical setting. Follow-up with participants was via regular office visits at intervals as determined by routine clinical practice or as recommended by national guidelines.

Eligibility criteria: Inclusion Criteria:

* Moderate to severe active rheumatoid arthritis in adults with insufficient response to disease-modifying antirheumatic drugs, including methotrexate
* Moderate to severe active rheumatoid arthritis in adults who have not been treated with methotrexate before. In case of incompatibility with methotrexate, Humira can be used as monotherapy

Exclusion Criteria:

* Hypersensitivity against the drug or one of the other ingredients
* Active tuberculosis or other severe infections (e.g. sepsis and opportunistic infections)
* Moderate to severe cardiac insufficiency

Primary outcomes:
measure: Change From Baseline in Disease Activity Score (DAS) 28
timeFrame: Baseline and Months 3, 6, 9, 12, 18, and 24
measure: Percentage of Participants in DAS28 Remission
timeFrame: Months 3, 6, 9, 12, 18, and 24
Secondary outcomes:
measure: Percentage of Participants With a Significant Therapeutic Response
timeFrame: Baseline and Months 3, 6, 9, 12, 18, and 24
measure: Percentage of Participants With Low, Moderate and High Disease Activity
timeFrame: Baseline and Months 3, 6, 9, 12, 18, and 24
measure: Erythrocyte Sedimentation Rate (ESR) Over Time
timeFrame: Baseline and Months 3, 6, 9, 12, 18, and 24
measure: C-Reactive Protein (CRP) Levels Over Time
timeFrame: Baseline and Months 3, 6, 9, 12, 18, and 24
measure: Tender Joint Count (TJC) Over Time
timeFrame: Baseline and Months 3, 6, 9, 12, 18, and 24
measure: Swollen Joint Count (SJC) Over Time
timeFrame: Baseline and Months 3, 6, 9, 12, 18, and 24
measure: Hannover Functional Questionnaire (FFbH) Over Time
timeFrame: Baseline and Months 3, 6, 9, 12, 18, and 24
measure: Patients Global Assessment of Disease Activity Over Time
timeFrame: Baseline and Months 3, 6, 9, 12, 18 and 24
measure: Participants Assessment of Fatigue Over Time
timeFrame: Baseline and Month 3, 6, 9, 12, 18, and 24
measure: Participants Assessment of Pain Over Time
timeFrame: Baseline and Months 3, 6, 9, 12, 18, and 24
measure: Percentage of Participants With Impairment in Daily Activities
timeFrame: Baseline and Months 3, 6, 9, 18, and 24
measure: Number of Days Missed From Work Due to Rheumatoid Arthritis
timeFrame: Baseline and Months 6, 12, 18, and 24
measure: Percentage of Participants With In-patient Hospitalization
timeFrame: Month 6, 12, 18, and 24
measure: Percentage of Participants on Concomitant Rheumatoid Arthritis and Pain Relief/Anti-inflammatory Medication
timeFrame: Baseline and Months 3, 6, 9, 12, 18, and 24
Other outcomes:
Locations:
city: Aachen
country: Germany
facility: Site Reference ID/Investigator# 35036
city: Ahlen
country: Germany
facility: Site Reference ID/Investigator# 35510
city: Ahrensburg
country: Germany
facility: Site Reference ID/Investigator# 35040
city: Altenburg
country: Germany
facility: Site Reference ID/Investigator# 35043
city: Altenholz
country: Germany
facility: Site Reference ID/Investigator# 35046
city: Amberg
country: Germany
facility: Site Reference ID/Investigator# 35049
city: Arnstadt
country: Germany
facility: Site Reference ID/Investigator# 35057
city: Attendorn
country: Germany
facility: Site Reference ID/Investigator# 35520
city: Augsburg
country: Germany
facility: Site Reference ID/Investigator# 33349
city: Bad Abbach
country: Germany
facility: Site Reference ID/Investigator# 33358
city: Bad Abbach
country: Germany
facility: Site Reference ID/Investigator# 33361
city: Bad Aibling
country: Germany
facility: Site Reference ID/Investigator# 35142
city: Bad Brambach
country: Germany
facility: Site Reference ID/Investigator# 35570
city: Bad Bramstedt
country: Germany
facility: Site Reference ID/Investigator# 35573
city: Bad Endbach
country: Germany
facility: Site Reference ID/Investigator# 33372
city: Bad Iburg
country: Germany
facility: Site Reference ID/Investigator# 33378
city: Bad Iburg
country: Germany
facility: Site Reference ID/Investigator# 33382
city: Bad Kreuznach
country: Germany
facility: Site Reference ID/Investigator# 33387
city: Bad Kreuznach
country: Germany
facility: Site Reference ID/Investigator# 35575
city: Bad Liebenwerda
country: Germany
facility: Site Reference ID/Investigator# 33391
city: Bad Muender
country: Germany
facility: Site Reference ID/Investigator# 33396
city: Bad Nauheim
country: Germany
facility: Site Reference ID/Investigator# 102216
city: Bad Neuenahr
country: Germany
facility: Site Reference ID/Investigator# 35578
city: Bad Rappenau
country: Germany
facility: Site Reference ID/Investigator# 33404
city: Bad Salzungen
country: Germany
facility: Site Reference ID/Investigator# 51883
city: Bad Soden-Salmuenster
country: Germany
facility: Site Reference ID/Investigator# 33412
city: Baden-Baden
country: Germany
facility: Site Reference ID/Investigator# 33425
city: Bamberg
country: Germany
facility: Site Reference ID/Investigator# 33429
city: Bautzen
country: Germany
facility: Site Reference ID/Investigator# 33438
city: Bayreuth
country: Germany
facility: Site Reference ID/Investigator# 33442
city: Bayreuth
country: Germany
facility: Site Reference ID/Investigator# 33446
city: Berlin-Buch
country: Germany
facility: Site Reference ID/Investigator# 34266
city: Berlin-Wannsee
country: Germany
facility: Site Reference ID/Investigator# 34252
city: Berlin
country: Germany
facility: Site Reference ID/Investigator# 33641
city: Berlin
country: Germany
facility: Site Reference ID/Investigator# 35089
city: Berlin
country: Germany
facility: Site Reference ID/Investigator# 33648
city: Berlin
country: Germany
facility: Site Reference ID/Investigator# 33693
city: Berlin
country: Germany
facility: Site Reference ID/Investigator# 33670
city: Berlin
country: Germany
facility: Site Reference ID/Investigator# 33658
city: Berlin
country: Germany
facility: Site Reference ID/Investigator# 33697
city: Berlin
country: Germany
facility: Site Reference ID/Investigator# 34246
city: Berlin
country: Germany
facility: Site Reference ID/Investigator# 33683
city: Berlin
country: Germany
facility: Site Reference ID/Investigator# 34269
city: Berlin
country: Germany
facility: Site Reference ID/Investigator# 35527
city: Berlin
country: Germany
facility: Site Reference ID/Investigator# 35597
city: Berlin
country: Germany
facility: Site Reference ID/Investigator# 33620
city: Berlin
country: Germany
facility: Site Reference ID/Investigator# 33690
city: Berlin
country: Germany
facility: Site Reference ID/Investigator# 33704
city: Berlin
country: Germany
facility: Site Reference ID/Investigator# 33687
city: Berlin
country: Germany
facility: Site Reference ID/Investigator# 33661
city: Berlin
country: Germany
facility: Site Reference ID/Investigator# 35550
city: Berlin
country: Germany
facility: Site Reference ID/Investigator# 33674
city: Berlin
country: Germany
facility: Site Reference ID/Investigator# 35551
city: Berlin
country: Germany
facility: Site Reference ID/Investigator# 34238
city: Bernau
country: Germany
facility: Site Reference ID/Investigator# 35556
city: Biberach
country: Germany
facility: Site Reference ID/Investigator# 34277
city: Binzen
country: Germany
facility: Site Reference ID/Investigator# 35562
city: Blankenburg/Hart
country: Germany
facility: Site Reference ID/Investigator# 34285
city: Blaubeuren
country: Germany
facility: Site Reference ID/Investigator# 34288
city: Bocholt
country: Germany
facility: Site Reference ID/Investigator# 34291
city: Bocholt
country: Germany
facility: Site Reference ID/Investigator# 35566
city: Bochum
country: Germany
facility: Site Reference ID/Investigator# 35641
city: Bogen
country: Germany
facility: Site Reference ID/Investigator# 35644
city: Bonn
country: Germany
facility: Site Reference ID/Investigator# 34302
city: Bonn
country: Germany
facility: Site Reference ID/Investigator# 35646
city: Bonn
country: Germany
facility: Site Reference ID/Investigator# 34296
city: Bottrop
country: Germany
facility: Site Reference ID/Investigator# 35652
city: Braunschweig
country: Germany
facility: Site Reference ID/Investigator# 34307
city: Breitenbrunn
country: Germany
facility: Site Reference ID/Investigator# 35603
city: Bremen
country: Germany
facility: Site Reference ID/Investigator# 35609
city: Celle
country: Germany
facility: Site Reference ID/Investigator# 35611
city: Chemnitz
country: Germany
facility: Site Reference ID/Investigator# 34699
city: Chemnitz
country: Germany
facility: Site Reference ID/Investigator# 35093
city: Coesfeld
country: Germany
facility: Site Reference ID/Investigator# 35615
city: Cologne
country: Germany
facility: Site Reference ID/Investigator# 33989
city: Cologne
country: Germany
facility: Site Reference ID/Investigator# 35237
city: Cottbus
country: Germany
facility: Site Reference ID/Investigator# 34708
city: Cottbus
country: Germany
facility: Site Reference ID/Investigator# 34711
city: Darmstadt
country: Germany
facility: Site Reference ID/Investigator# 35621
city: Deggendorf
country: Germany
facility: Site Reference ID/Investigator# 34725
city: Dessau-Rosslau
country: Germany
facility: Site Reference ID/Investigator# 35631
city: Dortmund
country: Germany
facility: Site Reference ID/Investigator# 34742
city: Dortmund
country: Germany
facility: Site Reference ID/Investigator# 35635
city: Dortmund
country: Germany
facility: Site Reference ID/Investigator# 35634
city: Dresden
country: Germany
facility: Site Reference ID/Investigator# 35170
city: Dresden
country: Germany
facility: Site Reference ID/Investigator# 34754
city: Dresden
country: Germany
facility: Site Reference ID/Investigator# 34748
city: Dresden
country: Germany
facility: Site Reference ID/Investigator# 34751
city: Dresden
country: Germany
facility: Site Reference ID/Investigator# 34760
city: Duesseldorf
country: Germany
facility: Site Reference ID/Investigator# 34773
city: Duesseldorf
country: Germany
facility: Site Reference ID/Investigator# 34768
city: Duisburg
country: Germany
facility: Site Reference ID/Investigator# 34778
city: Eberswalde
country: Germany
facility: Site Reference ID/Investigator# 34784
city: Elmshorn
country: Germany
facility: Site Reference ID/Investigator# 35184
city: Erfurt
country: Germany
facility: Site Reference ID/Investigator# 34809
city: Erfurt
country: Germany
facility: Site Reference ID/Investigator# 35096
city: Erfurt
country: Germany
facility: Site Reference ID/Investigator# 35191
city: Erlangen
country: Germany
facility: Site Reference ID/Investigator# 34821
city: Essen
country: Germany
facility: Site Reference ID/Investigator# 35196
city: Essen
country: Germany
facility: Site Reference ID/Investigator# 35199
city: Feldafing
country: Germany
facility: Site Reference ID/Investigator# 35202
city: Flensburg
country: Germany
facility: Site Reference ID/Investigator# 35205
city: Forchheim
country: Germany
facility: Site Reference ID/Investigator# 34833
city: Frankenberg
country: Germany
facility: Site Reference ID/Investigator# 35210
city: Frankfurt
country: Germany
facility: Site Reference ID/Investigator# 34849
city: Frankfurt
country: Germany
facility: Site Reference ID/Investigator# 34840
city: Frankfurt
country: Germany
facility: Site Reference ID/Investigator# 34843
city: Fraureuth
country: Germany
facility: Site Reference ID/Investigator# 35213
city: Freiberg
country: Germany
facility: Site Reference ID/Investigator# 35219
city: Freiburg
country: Germany
facility: Site Reference ID/Investigator# 34854
city: Freiburg
country: Germany
facility: Site Reference ID/Investigator# 35221
city: Freiburg
country: Germany
facility: Site Reference ID/Investigator# 34861
city: Freystadt
country: Germany
facility: Site Reference ID/Investigator# 35101
city: Friedrichroda
country: Germany
facility: Site Reference ID/Investigator# 35224
city: Gelsenkirchen
country: Germany
facility: Site Reference ID/Investigator# 34879
city: Gera
country: Germany
facility: Site Reference ID/Investigator# 34883
city: Giessen
country: Germany
facility: Site Reference ID/Investigator# 34887
city: Gosheim
country: Germany
facility: Site Reference ID/Investigator# 35491
city: Goslar
country: Germany
facility: Site Reference ID/Investigator# 34896
city: Greifswald
country: Germany
facility: Site Reference ID/Investigator# 34901
city: Greifswald
country: Germany
facility: Site Reference ID/Investigator# 35496
city: Greifswald
country: Germany
facility: Site Reference ID/Investigator# 34904
city: Gross Ammensleben
country: Germany
facility: Site Reference ID/Investigator# 102217
city: Guben
country: Germany
facility: Site Reference ID/Investigator# 35498
city: Guestrow
country: Germany
facility: Site Reference ID/Investigator# 34912
city: Hagen
country: Germany
facility: Site Reference ID/Investigator# 35503
city: Halle
country: Germany
facility: Site Reference ID/Investigator# 34937
city: Halle
country: Germany
facility: Site Reference ID/Investigator# 34940
city: Halle
country: Germany
facility: Site Reference ID/Investigator# 34922
city: Halle
country: Germany
facility: Site Reference ID/Investigator# 34944
city: Halle
country: Germany
facility: Site Reference ID/Investigator# 34932
city: Hamburg
country: Germany
facility: Site Reference ID/Investigator# 35444
city: Hamburg
country: Germany
facility: Site Reference ID/Investigator# 35441
city: Hamburg
country: Germany
facility: Site Reference ID/Investigator# 34970
city: Hamburg
country: Germany
facility: Site Reference ID/Investigator# 34952
city: Hamburg
country: Germany
facility: Site Reference ID/Investigator# 34958
city: Hamburg
country: Germany
facility: Site Reference ID/Investigator# 35452
city: Hamburg
country: Germany
facility: Site Reference ID/Investigator# 35007
city: Hamburg
country: Germany
facility: Site Reference ID/Investigator# 35000
city: Hamburg
country: Germany
facility: Site Reference ID/Investigator# 34961
city: Hamburg
country: Germany
facility: Site Reference ID/Investigator# 35449
city: Hamburg
country: Germany
facility: Site Reference ID/Investigator# 34955
city: Hamburg
country: Germany
facility: Site Reference ID/Investigator# 34998
city: Hamburg
country: Germany
facility: Site Reference ID/Investigator# 34994
city: Hamburg
country: Germany
facility: Site Reference ID/Investigator# 34983
city: Hamburg
country: Germany
facility: Site Reference ID/Investigator# 34986
city: Hamburg
country: Germany
facility: Site Reference ID/Investigator# 35111
city: Hamburg
country: Germany
facility: Site Reference ID/Investigator# 34974
city: Hanau
country: Germany
facility: Site Reference ID/Investigator# 35019
city: Hanover
country: Germany
facility: Site Reference ID/Investigator# 33712
city: Hanover
country: Germany
facility: Site Reference ID/Investigator# 35025
city: Harrislee
country: Germany
facility: Site Reference ID/Investigator# 33792
city: Haseluenne
country: Germany
facility: Site Reference ID/Investigator# 35459
city: Heidelberg
country: Germany
facility: Site Reference ID/Investigator# 102215
city: Heidelberg
country: Germany
facility: Site Reference ID/Investigator# 33798
city: Heidelberg
country: Germany
facility: Site Reference ID/Investigator# 35119
city: Heidelberg
country: Germany
facility: Site Reference ID/Investigator# 33801
city: Heidelberg
country: Germany
facility: Site Reference ID/Investigator# 33808
city: Heidenheim
country: Germany
facility: Site Reference ID/Investigator# 35464
city: Heilbad Heiligenstadt
country: Germany
facility: Site Reference ID/Investigator# 33818
city: Herrsching
country: Germany
facility: Site Reference ID/Investigator# 33825
city: Hofheim
country: Germany
facility: Site Reference ID/Investigator# 33842
city: Hof
country: Germany
facility: Site Reference ID/Investigator# 33834
city: Hohenfelde
country: Germany
facility: Site Reference ID/Investigator# 33845
city: Illertissen
country: Germany
facility: Site Reference ID/Investigator# 33855
city: Immenstadt
country: Germany
facility: Site Reference ID/Investigator# 33858
city: Ingolstadt
country: Germany
facility: Site Reference ID/Investigator# 35479
city: Jena
country: Germany
facility: Site Reference ID/Investigator# 51882
city: Juelich
country: Germany
facility: Site Reference ID/Investigator# 33942
city: Kahla
country: Germany
facility: Site Reference ID/Investigator# 33946
city: Kahla
country: Germany
facility: Site Reference ID/Investigator# 35125
city: Kaiserslautern
country: Germany
facility: Site Reference ID/Investigator# 33950
city: Karlsruhe
country: Germany
facility: Site Reference ID/Investigator# 33956
city: Karlsruhe
country: Germany
facility: Site Reference ID/Investigator# 33961
city: Kassel
country: Germany
facility: Site Reference ID/Investigator# 33964
city: Koenigs Wusterhausen
country: Germany
facility: Site Reference ID/Investigator# 34002
city: Kressbronn
country: Germany
facility: Site Reference ID/Investigator# 34008
city: Kronach
country: Germany
facility: Site Reference ID/Investigator# 34084
city: Lahr
country: Germany
facility: Site Reference ID/Investigator# 34005
city: Landau
country: Germany
facility: Site Reference ID/Investigator# 35245
city: Leipzig
country: Germany
facility: Site Reference ID/Investigator# 34112
city: Leipzig
country: Germany
facility: Site Reference ID/Investigator# 34106
city: Leipzig
country: Germany
facility: Site Reference ID/Investigator# 34109
city: Leipzig
country: Germany
facility: Site Reference ID/Investigator# 34100
city: Lippstadt
country: Germany
facility: Site Reference ID/Investigator# 35254
city: Ludwigsfelde
country: Germany
facility: Site Reference ID/Investigator# 35306
city: Ludwigshafen
country: Germany
facility: Site Reference ID/Investigator# 35262
city: Luebeck
country: Germany
facility: Site Reference ID/Investigator# 34136
city: Lueneburg
country: Germany
facility: Site Reference ID/Investigator# 34139
city: Magdeburg
country: Germany
facility: Site Reference ID/Investigator# 34147
city: Magdeburg
country: Germany
facility: Site Reference ID/Investigator# 34150
city: Mainz
country: Germany
facility: Site Reference ID/Investigator# 35276
city: Marktredwitz
country: Germany
facility: Site Reference ID/Investigator# 34192
city: Marl
country: Germany
facility: Site Reference ID/Investigator# 34196
city: Meissen
country: Germany
facility: Site Reference ID/Investigator# 34200
city: Menz
country: Germany
facility: Site Reference ID/Investigator# 35285
city: Minden
country: Germany
facility: Site Reference ID/Investigator# 35287
city: Mittelherwigsdorf
country: Germany
facility: Site Reference ID/Investigator# 34208
city: Moenchengladbach
country: Germany
facility: Site Reference ID/Investigator# 34218
city: Moenchengladbach
country: Germany
facility: Site Reference ID/Investigator# 34213
city: Moenkeberg
country: Germany
facility: Site Reference ID/Investigator# 34221
city: Muehlhausen
country: Germany
facility: Site Reference ID/Investigator# 34224
city: Muelheim
country: Germany
facility: Site Reference ID/Investigator# 35292
city: Muellheim
country: Germany
facility: Site Reference ID/Investigator# 34229
city: Muenster
country: Germany
facility: Site Reference ID/Investigator# 34048
city: Munich
country: Germany
facility: Site Reference ID/Investigator# 34040
city: Munich
country: Germany
facility: Site Reference ID/Investigator# 35295
city: Munich
country: Germany
facility: Site Reference ID/Investigator# 34232
city: Munich
country: Germany
facility: Site Reference ID/Investigator# 34235
city: Munich
country: Germany
facility: Site Reference ID/Investigator# 35298
city: Munich
country: Germany
facility: Site Reference ID/Investigator# 34043
city: Naunhof
country: Germany
facility: Site Reference ID/Investigator# 34052
city: Neubrandenburg
country: Germany
facility: Site Reference ID/Investigator# 34061
city: Neuburg
country: Germany
facility: Site Reference ID/Investigator# 34064
city: Neumuenster
country: Germany
facility: Site Reference ID/Investigator# 34071
city: Neuss
country: Germany
facility: Site Reference ID/Investigator# 35313
city: Neustadt
country: Germany
facility: Site Reference ID/Investigator# 34076
city: Niederbrombach
country: Germany
facility: Site Reference ID/Investigator# 35321
city: Niefern-Oeschelbronn
country: Germany
facility: Site Reference ID/Investigator# 34080
city: Nienburg
country: Germany
facility: Site Reference ID/Investigator# 34158
city: Oelsnitz
country: Germany
facility: Site Reference ID/Investigator# 34173
city: Offenburg
country: Germany
facility: Site Reference ID/Investigator# 34176
city: Oldenburg
country: Germany
facility: Site Reference ID/Investigator# 33492
city: Ostseebad Damp
country: Germany
facility: Site Reference ID/Investigator# 34718
city: Paderborn
country: Germany
facility: Site Reference ID/Investigator# 35335
city: Parchim
country: Germany
facility: Site Reference ID/Investigator# 33508
city: Passau
country: Germany
facility: Site Reference ID/Investigator# 35340
city: Pfullendorf
country: Germany
facility: Site Reference ID/Investigator# 33517
city: Pirna
country: Germany
facility: Site Reference ID/Investigator# 67482
city: Planegg
country: Germany
facility: Site Reference ID/Investigator# 33523
city: Plauen
country: Germany
facility: Site Reference ID/Investigator# 33528
city: Potsdam
country: Germany
facility: Site Reference ID/Investigator# 33470
city: Potsdam
country: Germany
facility: Site Reference ID/Investigator# 33466
city: Pruem
country: Germany
facility: Site Reference ID/Investigator# 33476
city: Puettlingen
country: Germany
facility: Site Reference ID/Investigator# 33479
city: Radebeul
country: Germany
facility: Site Reference ID/Investigator# 33484
city: Radebeul
country: Germany
facility: Site Reference ID/Investigator# 35347
city: Ratingen
country: Germany
facility: Site Reference ID/Investigator# 35136
city: Ratzeburg
country: Germany
facility: Site Reference ID/Investigator# 33488
city: Regensburg
country: Germany
facility: Site Reference ID/Investigator# 33890
city: Regensburg
country: Germany
facility: Site Reference ID/Investigator# 33883
city: Regensburg
country: Germany
facility: Site Reference ID/Investigator# 33886
city: Reken
country: Germany
facility: Site Reference ID/Investigator# 33897
city: Rendsburg
country: Germany
facility: Site Reference ID/Investigator# 33902
city: Rheine
country: Germany
facility: Site Reference ID/Investigator# 33907
city: Rickenbach
country: Germany
facility: Site Reference ID/Investigator# 35355
city: Riesa
country: Germany
facility: Site Reference ID/Investigator# 33911
city: Rinteln
country: Germany
facility: Site Reference ID/Investigator# 33914
city: Rostock
country: Germany
facility: Site Reference ID/Investigator# 33923
city: Rostock
country: Germany
facility: Site Reference ID/Investigator# 33927
city: Rothenburg
country: Germany
facility: Site Reference ID/Investigator# 33931
city: Ruedersdorf
country: Germany
facility: Site Reference ID/Investigator# 35362
city: Saarbruecken
country: Germany
facility: Site Reference ID/Investigator# 34016
city: Salzwedel
country: Germany
facility: Site Reference ID/Investigator# 34023
city: Sande
country: Germany
facility: Site Reference ID/Investigator# 34027
city: Schneeberg
country: Germany
facility: Site Reference ID/Investigator# 33534
city: Schramberg
country: Germany
facility: Site Reference ID/Investigator# 33539
city: Schutterwald
country: Germany
facility: Site Reference ID/Investigator# 33542
city: Schwandorf
country: Germany
facility: Site Reference ID/Investigator# 35371
city: Schwerin
country: Germany
facility: Site Reference ID/Investigator# 33549
city: Schwerin
country: Germany
facility: Site Reference ID/Investigator# 35376
city: Schwerte
country: Germany
facility: Site Reference ID/Investigator# 33555
city: Seesen
country: Germany
facility: Site Reference ID/Investigator# 33559
city: Senden
country: Germany
facility: Site Reference ID/Investigator# 33563
city: Singen
country: Germany
facility: Site Reference ID/Investigator# 35380
city: Sinsheim
country: Germany
facility: Site Reference ID/Investigator# 33567
city: Soltau
country: Germany
facility: Site Reference ID/Investigator# 33572
city: Spremberg
country: Germany
facility: Site Reference ID/Investigator# 33577
city: St. Martin
country: Germany
facility: Site Reference ID/Investigator# 35383
city: Stadthagen
country: Germany
facility: Site Reference ID/Investigator# 33588
city: Steinhagen
country: Germany
facility: Site Reference ID/Investigator# 33592
city: Stuttgart
country: Germany
facility: Site Reference ID/Investigator# 33604
city: Stuttgart
country: Germany
facility: Site Reference ID/Investigator# 33607
city: Stuttgart
country: Germany
facility: Site Reference ID/Investigator# 33611
city: Stuttgart
country: Germany
facility: Site Reference ID/Investigator# 33598
city: Suhl
country: Germany
facility: Site Reference ID/Investigator# 35389
city: Tegernau
country: Germany
facility: Site Reference ID/Investigator# 35391
city: Torgelow
country: Germany
facility: Site Reference ID/Investigator# 33625
city: Ueberlingen-Nussdorf
country: Germany
facility: Site Reference ID/Investigator# 33637
city: Uffenheim
country: Germany
facility: Site Reference ID/Investigator# 35395
city: Ulm
country: Germany
facility: Site Reference ID/Investigator# 33721
city: Ulm
country: Germany
facility: Site Reference ID/Investigator# 33724
city: Viersen
country: Germany
facility: Site Reference ID/Investigator# 33734
city: Villingen-Schwenningen
country: Germany
facility: Site Reference ID/Investigator# 33737
city: Voehringen
country: Germany
facility: Site Reference ID/Investigator# 35397
city: Waltrop
country: Germany
facility: Site Reference ID/Investigator# 33742
city: Weener
country: Germany
facility: Site Reference ID/Investigator# 33749
city: Weissenfels
country: Germany
facility: Site Reference ID/Investigator# 33751
city: Welzow
country: Germany
facility: Site Reference ID/Investigator# 33852
city: Wiefelstede
country: Germany
facility: Site Reference ID/Investigator# 35404
city: Wiesbaden
country: Germany
facility: Site Reference ID/Investigator# 33761
city: Wiesbaden
country: Germany
facility: Site Reference ID/Investigator# 35408
city: Wiesbaden
country: Germany
facility: Site Reference ID/Investigator# 33765
city: Wiesbaden
country: Germany
facility: Site Reference ID/Investigator# 35413
city: Wilhelmshaven
country: Germany
facility: Site Reference ID/Investigator# 33772
city: Wittlich
country: Germany
facility: Site Reference ID/Investigator# 33780
city: Wuerzburg
country: Germany
facility: Site Reference ID/Investigator# 33718
city: Wuppertal
country: Germany
facility: Site Reference ID/Investigator# 35420
city: Zerbst
country: Germany
facility: Site Reference ID/Investigator# 33864
city: Zeven
country: Germany
facility: Site Reference ID/Investigator# 33867
city: Zwickau
country: Germany
facility: Site Reference ID/Investigator# 33873
city: Zwickau
country: Germany
facility: Site Reference ID/Investigator# 33876
city: Zwiesel
country: Germany
facility: Site Reference ID/Investigator# 33880
Study officials:
affiliation: AbbVie Deutschland GmbH & Co. KG, Medical Department
name: Bianca Wittig, MD
role: STUDY_DIRECTOR
References:
citation: Behrens F, Koehm M, Schwaneck EC, Schmalzing M, Wittig BM, Gnann H, Greger G, Tony HP, Burkhardt H. Addition or removal of concomitant methotrexate alters adalimumab effectiveness in rheumatoid arthritis but not psoriatic arthritis. Scand J Rheumatol. 2019 Sep;48(5):375-382. doi: 10.1080/03009742.2019.1600717. Epub 2019 Jul 16.
citation: Scharbatke EC, Behrens F, Schmalzing M, Koehm M, Greger G, Gnann H, Burkhardt H, Tony HP. Association of Improvement in Pain With Therapeutic Response as Determined by Individual Improvement Criteria in Patients With Rheumatoid Arthritis. Arthritis Care Res (Hoboken). 2016 Nov;68(11):1607-1615. doi: 10.1002/acr.22884. Epub 2016 Oct 1.