Clinical trial NCT03374124: The Surgical Prognosis Based Diagnostic Strategy for Eosinophilic Chronic Rhinosinusitis
Official title: The Surgical Prognosis Based Diagnostic Strategy for Eosinophilic Chronic Rhinosinusitis: A Retrospective Study
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Sinusitis
Nasal Polyps
Keywords: Chronic rhinosinusitis
Eosinophil
Surgery
Diagnosis
Lead sponsor: First Affiliated Hospital, Sun Yat-Sen University
Sponsor class: OTHER
First posted: 2017-12-15
Enrollment: 100
Sex: ALL
Minimum age (years): 18
Maximum age (years): 70
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: RETROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: Chronic rhinosinusitis patients after endoscopic surgery

Brief summary: Previous studies have demonstrated that the eosinophilic inflammation of nasal mucosa is associated with the uncontrolled condition of chronic rhinosinusitis after surgery. However, the definition of the eosinophilic chronic rhinosinusitis is not very clear. Japanese researchers have designed a scoring system to diagnose eosinophilic chronic rhinosinusitis. In this study, the investigators hope to examine the practicability of this scoring system and have a better knowledge of eosinophilic chronic rhinosinusitis in china.The retrospective study was conducted in a tertiary hospital. Participants received functional endoscopic sinus surgery more than 1 years were called back for evaluation. A diagnosis cut off value of eosinophil count was determined by the surgery prognosis. Then different factors were compared between participants with eosinophilic CRS and those with non-eosinophilic CRS to establish the appropriated diagnosis approach for eosinophilic CRS.

Detailed description: The retrospective study was conducted in a tertiary hospital. Participants received functional endoscopic sinus surgery more than 1 years were called back for evaluation. A diagnosis cut off value of eosinophil count was determined by the surgery prognosis. Then different factors were compared between participants with eosinophilic CRS and those with non-eosinophilic CRS to establish the appropriated diagnosis approach for eosinophilic CRS.

Eligibility criteria: Inclusion Criteria:

* Diagnosis of chronic rhinosinusitis according to European position paper of rhinosinusitis and nasal polyps 2007.

Exclusion Criteria:

* Immunodeficiency diseases, history of head and/or facial trauma, cancer or organ transplant recipients.
* Pregnancy or lactation.
* Acute respiratory tract infection within one month before the study.
* Patients without pathological samples.
* Antrochoanal polyp and cyst of the paranasal sinuses.

Primary outcomes:
measure: nasal symptoms
timeFrame: through study completion, an average of 2 year
measure: endoscopic appearance indicate the uncontrol of CRS
timeFrame: through study completion, an average of 2 year
Secondary outcomes:
Other outcomes:
Locations:
city: Guangzhou
country: China
facility: the first affiliated hospital, Sun Yat-sen University
state: Guangdong
Study officials:
affiliation: Ent department, the first affiliated hospital, Sun Yat-sen University
name: Jianbo Shi, doctor
role: STUDY_DIRECTOR
References: