Clinical trial NCT06928558: Preoperative Anemia in the Oncology Population and Associated Mortality
Official title: Prevalence of Preoperative Anemia in the Oncology Population and Associated Mortality
Study type: OBSERVATIONAL
Overall status: NOT_YET_RECRUITING
Conditions: Anemia
Oncologic Surgery
Keywords: Anemia
Oncologic Surgery
Anesthesia
Lead sponsor: University of Chile
Sponsor class: OTHER
First posted: 2025-04-15
Enrollment: 850
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: RETROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Consecutive patients operated at the National Cancer Institute will be included in a retrospective cohort study between January and December 2022.

Brief summary: Anemia is a highly prevalent condition in the surgical population (1, 2). On the other hand, the oncology population is at higher risk of developing anemia due to specific treatments for the disease, such as chemotherapy and radiotherapy. Preoperative anemia has been associated with an increased risk of postoperative morbidity and even mortality (3). Despite this, the prevalence of preoperative anemia in the Chilean oncology population has not been quantified. To answer this question, a retrospective cohort study was designed between January and December 2022 to quantify the prevalence of anemia in the surgical population of the National Cancer Institute. In addition, the impact on morbidity and mortality at 30 days, 6 months, and 1 year will be evaluated. Statistical analysis will be performed using R. Studio Version 2023.09.1+494 (2023.09.1+494).

Detailed description: General Objective:

To quantify the prevalence of preoperative anemia in the National Cancer Institute's oncology surgical population and its impact on postoperative outcomes.

Specific Objectives:

1. To quantify the prevalence of preoperative anemia in the National Cancer Institute's oncology population.
2. To stratify the prevalence of preoperative anemia in the National Cancer Institute's oncology population by severity.
3. To assess 30-day, 6-month, and 1-year mortality in cancer patients with and without anemia in the National Cancer Institute's oncology population.

Eligibility criteria: Inclusion Criteria:

* Patients over 18 years of age
* Oncologic surgery with curative intent

Exclusion Criteria:

* Emergency surgery
* Patients who received a preoperative transfusion
* Patients without a preoperative blood count

Primary outcomes:
measure: Prevalence of preoperative anemia
timeFrame: 1 year
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
References:
citation: Sim YE, Abdullah HR. Implications of Anemia in the Elderly Undergoing Surgery. Clin Geriatr Med. 2019 Aug;35(3):391-405. doi: 10.1016/j.cger.2019.04.001. Epub 2019 May 27.
citation: Goodnough LT, Shander A, Spivak JL, Waters JH, Friedman AJ, Carson JL, Keating EM, Maddox T, Spence R. Detection, evaluation, and management of anemia in the elective surgical patient. Anesth Analg. 2005 Dec;101(6):1858-1861. doi: 10.1213/01.ANE.0000184124.29397.EB.
citation: Musallam KM, Tamim HM, Richards T, Spahn DR, Rosendaal FR, Habbal A, Khreiss M, Dahdaleh FS, Khavandi K, Sfeir PM, Soweid A, Hoballah JJ, Taher AT, Jamali FR. Preoperative anaemia and postoperative outcomes in non-cardiac surgery: a retrospective cohort study. Lancet. 2011 Oct 15;378(9800):1396-407. doi: 10.1016/S0140-6736(11)61381-0. Epub 2011 Oct 5.