Clinical trial NCT05097885: Health Benefits of Whole-body Vibration
Official title: Pilot Investigation on the Health Benefits of Sub Acute (12 Week) Whole-body Vibration Training
Study type: INTERVENTIONAL
Overall status: RECRUITING
Phase: NA
Conditions: Whole-body Vibration
Lead sponsor: Augusta University
Sponsor class: OTHER
First posted: 2021-10-28
Enrollment: 40
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: TREATMENT

Brief summary: The overall goals of this pilot investigation are to determine 1) the feasibility of conducting home based WBV studies, and 2) to determine if sub-acute home based WBV can improve a) exercise capacity, b) conduit- and micro- vascular function, and c) skeletal muscle function.

Detailed description: Cardiovascular disease (CVD) is the leading cause of death in the world and many comorbid conditions (i.e. diabetes, obesity) can affect overall CVD risk. There is increasing interest into the role that skeletal muscle health plays in mediating CVD risk, particularly in metabolic disease states (ie. obesity and diabetes). Whole body vibration (WBV) has emerged as an exercise mimetic that may be more tolerable than traditional modes of exercise, such as treadmill walking/running or cycling. Similar to traditional exercise modalities, WBV can elicit beneficial metabolic effects. In fact, a single bout of WBV increases circulating concentrations of IL-6, which correspond with the normalization of glucose and insulin in obese individuals. The proposed pilot investigation will provide the foundation to begin understanding the molecular and physiological mechanisms of how sub-acute WBV can improve overall CVD risk. We hypothesize that home based WBV will decrease CVD risk by improving skeletal muscle and vascular function via a decrease in systemic inflammation.

Eligibility criteria: Inclusion Criteria:

* Men and women (\> 18 yrs old)
* All races

Exclusion Criteria:

* \<18 years old
* Clinical diagnosis of hepatic, cardiovascular, or renal disease
* Diabetic complications (i.e. macrovascular, microvascular, or autonomic)
* Pregnancy
* Direct vasoactive medications (i.e. nitrates)

Primary outcomes:
measure: Change in VO2 Peak
timeFrame: pre-treatment baseline and following 12 weeks sub-acute whole-body vibration
measure: Change in Flow-Mediated Dilation (FMD)
timeFrame: pre-treatment baseline and following 12 weeks sub-acute whole-body vibration
measure: Change in Skeletal Muscle Mitochondrial Function
timeFrame: pre-treatment baseline and following 12 weeks sub-acute whole-body vibration
measure: Change in Pulse Wave Velocity (PWV)
timeFrame: pre-treatment baseline and following 12 weeks sub-acute whole-body vibration
measure: Change in Post Occlusive Reactive Hyperemia (PORH)
timeFrame: pre-treatment baseline and following 12 weeks sub-acute whole-body vibration
measure: Change in IL-6
timeFrame: pre-treatment baseline and following 12 weeks sub-acute whole-body vibration
Secondary outcomes:
Other outcomes:
Locations:
city: Augusta
country: United States
facility: Augusta University/Georgia Prevention Institute/ Laboratory of Integrative and Exercise Physiology
state: Georgia
Study officials:
References: