louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT05117437: The Effect Of Anaerobic Exercise On Bone Morphogenetic Protein 9
Official title: The Effect Of Anaerobic Exercise On Bone Morphogenetic Protein 9
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Healthy
Exercise
Keywords: Bone morphogenetic protein
BMP9
anaerobic exercise
Lead sponsor: Ege University
Sponsor class: OTHER
First posted: 2021-11-11
Enrollment: 81
Sex: MALE
Minimum age (years): 18
Maximum age (years): 35
Standard ages: ADULT
Accepts healthy volunteers: yes
Observational model: COHORT
Time perspective: CROSS_SECTIONAL
Sampling method: PROBABILITY_SAMPLE
Study population: Athletic group: trained male athletes who did anaerobic sports (such as basketball, volleyball and handball) Control group: sedentary males

Brief summary: Bone morphogenetic protein (BMP) 9 from the BMP family has an important role in the remodeling of bone and cartilage. Due to these features, BMP9 can play an important role in especially anaerobic exercise training adaptations. However, the role of anaerobic exercise in these effects is still unclear. The aim of this study is to investigate the role of BMP9 on the effects of acute and chronic anaerobic exercise on bone metabolism markers. Postprandial venous blood samples were taken pre- and post- acute YOYO intermittent recovery test (level 1) in 40 trained male athletes aged 18-35 who did anaerobic sports (such as basketball, volleyball and handball) and 41 sedentary volunteers aged 18-35. Serum BMP9, as markers of bone formation and resorption; alkaline phosphatase (ALP), C-terminal telopeptide of type 1 collagen (CTX1), cartilage oligomeric matrix protein (COMP) and calcium levels were determined. The data to be obtained as a result of our study can give information about the relationship between the skeletal and bone health of the athletes and anaerobic exercise.


Eligibility criteria: Inclusion Criteria:

* being male
* having a body mass index of less than 30 being

Exclusion Criteria:

* to have some disease or disability
* to regularly use cigarettes and alcohol
* to use any medication or antioxidant substance

Primary outcomes:
measure: Change from serum BMP9 levels at pre- and post- YOYO intermittent test
timeFrame: between 40-50 minutes
measure: Change from serum CTX1 levels at pre- and post- YOYO intermittent test
timeFrame: between 40-50 minutes
measure: Change from serum COMP levels at pre- and post- YOYO intermittent test
timeFrame: between 40-50 minutes
Secondary outcomes:
Other outcomes:
Locations:
city: İzmir
country: Turkey
facility: Ege University Faculty of Sport Sciences
Study officials:
affiliation: Ege University Faculty of Sport Sciences
name: Faruk Turgay
role: STUDY_DIRECTOR
References:
Clinical trial NCT04100837: Multiple Instrumentation for ACL Reconstruction Regarding Bacterial Contamination
Official title: Effect of Multiple Instrumentation in Transportal and Transtibial Techniques for ACL Reconstruction Regarding Bacterial Contamination: A Randomized Control Study
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Anterior Cruciate Ligament Injuries
Lead sponsor: Assiut University
Sponsor class: OTHER
First posted: 2019-09-24
Enrollment: 80
Sex: ALL
Minimum age (years): 18
Maximum age (years): 40
Standard ages: ADULT
Accepts healthy volunteers: no
Observational model: OTHER
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Total coverage of all eligible cases will be admitted to Arthoscopic Unit within 6 months

Brief summary: To determine the Effect of multiple instrumentation regarding bacterial contamination in transportal and transtibial techniques in ACL reconstruction .A Randomized controlled study

Detailed description: Infection is a catastrophic and one of the most dreaded complications in orthopaedic surgery. Several measures have been undertaken to reduce the risk of infection, one of which is the use of systemic prophylactic antibiotics.

The purpose of this study is to determine the effect of multiple instrumentation regarding bacterial contamination in transportal and transtibial techniques in ACL reconstruction . About Eighty consecutive patients having surgical indication for ACL-R will be included, the cases will be divided into two groups, 35 cases will undergo for the transtibial technique and the other 45 cases will undergo for the transportal technique. After preparation, swabs will be obtained from subcutaneous tissue at antromedial portal track in transportal technique (femoral tunnel drilling) and in transtibial technique before and after the instrumentation and femoral screw insertion, a control sample will be taken at antrolateral track in both techniques, then samples will be sended to the lab to be studied.

Eligibility criteria: Inclusion Criteria:

1. Isolated ACL Injury.
2. Non deformed knee.

Exclusion Criteria:

1. Associated knee injury (eg. PCL).
2. Deformed knee ( eg. genu varus , genu valgus more than 4 degree )
3. patient with medical history of being immune compromized patient eg,DM

Primary outcomes:
measure: Assessment the concentration of contamination in ACL operation.
timeFrame: Through study completion, an average of 1 year.
Secondary outcomes:
Other outcomes:
Locations:
city: Assiut
country: Egypt
facility: Assiut Univeristy
Study officials:
affiliation: Assiut University
name: Hesham HK El-kadi, professor
role: STUDY_DIRECTOR
References:
citation: Barnstable CJ, Jones EA, Bodmer WF, Bodmer JG, Arce-Gomez B, Snary D, Crumpton MJ. Genetics and serology of HL-A-linked human Ia antigens. Cold Spring Harb Symp Quant Biol. 1977;41 Pt 2:443-55. doi: 10.1101/sqb.1977.041.01.052. No abstract available.
Clinical trial NCT05797337: Knowledge and Attitude of Dialysis Center Medical Staff Towards Living Kidney Donation
Official title: Knowledge and Attitude of Dialysis Center Medical Staff Towards Living Kidney Donation
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Kidney Transplant
Lead sponsor: Andrzej Frycz Modrzewski Krakow University
Sponsor class: OTHER
First posted: 2023-04-04
Enrollment: 500
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: OTHER
Time perspective: CROSS_SECTIONAL
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Dialysis center workers (doctors, nurses)

Brief summary: The goal of this cross-sectional study is to learn about the level of knowledge and attitudes of medical staff working in dialysis centers about living kidney donations. The main questions it aims to answer are:

* What is the level of knowledge of dialysis center medical staff regarding living kidney transplantations?
* How much time does the staff have for educating the patients about living kidney donations? Participants will be asked to answer a self-report questionnaire along with two standardized tools.


Eligibility criteria: Inclusion Criteria:

* Voluntary consent to participate in the study.
* Communicative knowledge of the Polish language.
* Each potential participant will receive comprehensive information about the purpose and course of the study before participating in the study and will consent to the study.
* Dialysis station employee: doctor, nurse.

Exclusion Criteria:

* no consent
* no communicative knowledge of the Polish language
* not working in dialysis center currently

Primary outcomes:
measure: Knowledge and attitudes of dialysis centers medical workers toward living kidney donations.
timeFrame: 22 months
measure: How satisfaction with life impacts attitudes toward living kidney donation
timeFrame: 22 months
measure: How self-esteem impacts attitudes toward living kidney donation
timeFrame: 22 months
measure: How empathy impacts attitudes toward living kidney donation
timeFrame: 22 months
measure: How self-efficacy impacts attitudes toward living kidney donation
timeFrame: 22 monts
Secondary outcomes:
Other outcomes:
Locations:
city: Kraków
country: Poland
facility: Andrzej Frycz Modrzewski Krakow University
Study officials:
References:
Clinical trial NCT05892315: Timing of Re-evaluation After Steps I-II of Periodontal Therapy
Official title: Timing of Re-evaluation After Steps I-II of Periodontal Therapy: a Randomized Clinical Trial
Study type: INTERVENTIONAL
Overall status: RECRUITING
Phase: NA
Conditions: Periodontitis
Lead sponsor: University of Turin, Italy
Sponsor class: OTHER
First posted: 2023-06-07
Enrollment: 60
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: Literature on non surgical periodontal therapy (NSPT) shows lack of clarity in reporting information on re-evaluation timing and clinical response. If the re-evaluation was done shortly after NSPT, this is also likely to have an influence on the surgical treatment plan. The aim of this randomized clinical trial is to investigate the effect of re-evaluation timing at 1-3-6 months after NSPT in terms of pocket closure, probing pocket depth reduction, comprehensive treatment plan, and costs for the patient.


Eligibility criteria: Inclusion Criteria:

* Periodontitis stage III-IV
* Full-mouth plaque score (FMPS) \< 25% at the 1-month re-evaluation
* Full-mouth bleeding score (FMBS) \< 25% at the 1-month re-evaluation
* Signed informed consent

Exclusion criteria:

* Age \< 18 yo
* Pregnancy or lactation
* Heavy smokers (\>10 die)
* Conditions or diseases influencing periodontal healing
* Patients that cannot complete the 6 months follow-up

Primary outcomes:
measure: Change in treatment success % (0 - 100 % with higher percentage indicating better status)
timeFrame: Baseline, 1 month, 3 months and 6 months after the completion of the therapy.
Secondary outcomes:
measure: Change in Full Mouth Plaque Score (FMPS%) (0 - 100 % with higher percentage indicating worse status)
timeFrame: Baseline, 1 month, 3 months and 6 months after the completion of the therapy.
measure: Change in Probing Pocket Depth (PD) (0 - 15 mm with higher values indicating worse outcomes).
timeFrame: Baseline, 1 month, 3 months and 6 months after the completion of the therapy.
measure: Change in Clinical Attachment Level (CAL) (0 - 15 mm with higher values indicating worse outcomes).
timeFrame: Baseline, 1 month, 3 months and 6 months after the completion of the therapy.
Other outcomes:
Locations:
city: Turin
country: Italy
facility: CIR Dental School
Study officials:
References:
Clinical trial NCT00176215: Clinical Comparison of RPDs Retained by Conical and Galvanoformed Double Crowns.
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: PHASE4
Conditions: Denture, Partial, Removable
Dental Prosthesis Retention
Oral Health
Tooth Abrasion
Lead sponsor: Heidelberg University
Sponsor class: OTHER
First posted: 2005-09-15
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Allocation: RANDOMIZED
Intervention model: SINGLE_GROUP
Primary purpose: TREATMENT

Brief summary: The aim of this prospective clinical trial was to investigate the clinical performance and complication rate of RPDs (Removable partial dentures) retained on conventional conical double crowns in comparison to galvanoformed telscopic double crowns. Additionally the OHIP (Oral Health related Qualitiy of Life)and the abrasion of the teeth were investigated.


Eligibility criteria: Inclusion Criteria:

* Indication for RPDs retained by double crowns; 2 to 6 Abutment teeth;

Exclusion Criteria:

* limited contractual capability and absence of consent of the patient

Primary outcomes:
Secondary outcomes:
Other outcomes:
Locations:
city: Heidelberg
country: Germany
facility: University of Heidelberg
state: Baden-Württemberg
city: Heidelberg
country: Germany
facility: University of Heidelberg
state: Baden_Württemberg
Study officials:
affiliation: Heidelberg University
name: Christiane Grossmann, DDS
role: STUDY_CHAIR
affiliation: Heidelberg University
name: Franziska Lehmann, DDS
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT02340715: Advanced MRI Sequences for Radiation Therapy Treatment Planning
Official title: Investigation on the Utility of Advanced MRI Imaging Methods for Radiation Therapy Treatment Planning
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Cancer
Keywords: Anal canal
Brain
Breast
Cervix
Esophagus
Gynecology
Head and Neck
Lung
Pancreas
Primary liver or liver metastases
Prostate cancer
Sarcoma
Lead sponsor: Medical College of Wisconsin
Sponsor class: OTHER
First posted: 2015-01-19
Enrollment: 158
Sex: ALL
Minimum age (years): 18
Maximum age (years): 89
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: CASE_CONTROL
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: Subjects who are planning to have radiation therapy for their cancer.

Brief summary: The purpose of this study is to determine if it would be helpful to use advanced MRI imaging techniques to take additional views of the tumor target for radiation treatment planning or treatment follow-up MRI.

Detailed description: The results of this research project will be used to establish a standard MRI protocol specific to each tumor or disease site. An MRI protocol is a list of MR image types that are acquired for each disease site. These images are used to generate the patient's treatment plan.

Eligibility criteria: Inclusion Criteria:

* Patients aged 18 years older of any race or gender with anal canal, brain, breast, cervix, esophagus, gynecology, head and neck, lung, pancreas, primary liver or liver metastases, prostate cancer or sarcoma either undergoing MRI scan for radiation treatment planning or a post treatment MRI
* Voluntarily signs an IRB approved consent form

Exclusion Criteria:

* Inability to obtain informed consent from the patient or their medical power of attorney
* Patients who are not undergoing MR for radiation treatment planning
* Patients who will not have MRI scans after treatment
* Patients with pacemakers or other non-MRI compatible metallic implants
* Pregnant women, by self report using a standard MRI questionnaire
* Patients who will not receive contrast agent as part of their standard MR, will participate only in the non-contrast portion of the study

Primary outcomes:
measure: Number of Participants Successfully Contributing MRI Data
timeFrame: up to 4 weeks from imaging
Secondary outcomes:
Other outcomes:
Locations:
city: Milwaukee
country: United States
facility: Froedtert Hospital
state: Wisconsin
Study officials:
affiliation: Medical College of Wisconsin
name: Ergun Ahunbay, PhD
role: PRINCIPAL_INVESTIGATOR
References:
citation: Khoo VS, Dearnaley DP, Finnigan DJ, Padhani A, Tanner SF, Leach MO. Magnetic resonance imaging (MRI): considerations and applications in radiotherapy treatment planning. Radiother Oncol. 1997 Jan;42(1):1-15. doi: 10.1016/s0167-8140(96)01866-x.
Clinical trial NCT00421915: Study Evaluating Etanercept Treatment of Patients With Ankylosing Spondylitis
Official title: Multicenter, Double-Blind, Parallel, Placebo-Controlled, Randomised Phase 3 Study of Etanercept in the Treatment of Patients With Ankylosing Spondylitis: 12-Week Final Data
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE3
Conditions: Ankylosing Spondylitis
Lead sponsor: Wyeth is now a wholly owned subsidiary of Pfizer
Sponsor class: INDUSTRY
First posted: 2007-01-15
Enrollment: 84
Sex: ALL
Minimum age (years): 18
Maximum age (years): 70
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The primary objective of the study was to compare the efficacy of etanercept (25 mg, twice weekly) with that of placebo based on the percentage of patients who achieve the Assessment in Ankylosing Spondylitis (ASAS) response criteria (ASAS 20%) at week 12.


Eligibility criteria: Main inclusion criteria

* Diagnosis of AS (defined by Modified New York Criteria for Ankylosing Spondylitis).
* Active AS (defined by the average of scores on the visual analog scale \[VAS\] of ≥ 30 for duration and intensity of morning stiffness and by 2 of the following: VAS for patient global assessment ≥ 30; average of VAS for nocturnal and total pain ≥ 30; BASFI ≥ 30 (all scores on a scale of 0 to 100).
* 18 to 70 years of age.

Main exclusion criteria

* Complete ankylosis (fusion) of spine.
* Previous receipt of etanercept, antibody to tumour necrosis factor alpha (TNFα), or other TNFα inhibitors.
* Use of disease-modifying antirheumatic drugs (DMARDs) other than hydroxychloroquine, sulphasalazine, or methotrexate within 4 weeks of baseline.

Primary outcomes:
measure: To compare the efficacy of etanercept (25 mg, twice weekly) with that of placebo based on the
measure: percentage of patients who achieved the assessment in Ankylosing Spondylitis (ASAS 20%) response criteria at week 12.
Secondary outcomes:
measure: To assess: 1) the safety of etanercept in this patient population; 2) the efficacy of etanercept
measure: compared with that of placebo using the ASAS response criteria at 50% and 70% levels at week 12.
Other outcomes:
Locations:
Study officials:
affiliation: Wyeth is now a wholly owned subsidiary of Pfizer
name: Medical Monitor
role: STUDY_DIRECTOR
References:
citation: Baraliakos X, Szumski A, Koenig AS, Jones H. The role of C-reactive protein as a predictor of treatment response in patients with ankylosing spondylitis. Semin Arthritis Rheum. 2019 Jun;48(6):997-1004. doi: 10.1016/j.semarthrit.2018.10.019. Epub 2018 Nov 2.
Clinical trial NCT06749015: A Study on Treatment for Patients With BRAFV600E Mutant Metastatic Colorectal Cancer (mCRC)
Official title: A Multicenter, Retrospective, Observational Study on Treatment for Patients With BRAFV600E Mutant Metastatic Colorectal Cancer (mCRC)
Study type: OBSERVATIONAL
Overall status: RECRUITING
Conditions: Metastatic Colorectal Cancer
BRAF V600 Mutation
Lead sponsor: Fudan University
Sponsor class: OTHER
First posted: 2024-12-27
Enrollment: 100
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Observational model: COHORT
Time perspective: RETROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Diagnosis of histologically or cytologically confirmed mCRC with BRAFV600E mutation

Brief summary: Previous studies have shown that BRAFV600E mutant mCRC patients have a shorter survival time than BRAF wild type mCRC patients. For Chinese patients, however, it remains unclear about the BRAF gene mutation rate, diagnosis, prognosis and survival data in people with BRAFV600E mutant mCRC .

This real-world, multicenter non-interventional study (NIS) will describe the mutation rate, treatment patterns, effectiveness and safety of current treatment regimens in BRAFV600E mutant mCRC patients in China.


Eligibility criteria: Inclusion Criteria:

* Diagnosis of histologically or cytologically confirmed CRC that is metastatic and unresectable
* Presence of BRAFV600E mutation in tumor tissue, as confirmed by a local assay

Exclusion Criteria:

* patients with previous chronic inflammatory bowel disease, chronic diarrhea or recurrent bowel obstruction patients with symptomatic brain metastases active clinical severe infection

Primary outcomes:
measure: Progression-free Survival (PFS)
timeFrame: 6 months
Secondary outcomes:
measure: Overall Survival (OS)
timeFrame: 24 months
measure: Overall Response rate (ORR)
timeFrame: 6 months
Other outcomes:
Locations:
city: Shanghai
country: China
facility: Fudan University Shanghai Cancer Center
state: Shanghai
Study officials:
References:
Clinical trial NCT04390815: Effect of Insulin on Wound Healing-A Randomized Controlled Trial
Official title: Effect of Insulin on Wound Healing- A Randomized Controlled Trial
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: PHASE4
Conditions: Wound Heal
Lead sponsor: Ministry of Health, Bahrain
Sponsor class: OTHER_GOV
First posted: 2020-05-18
Enrollment: 30
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: A randomized controlled trial examining the effect of insulin on wound healing in both diabetics and non diabetic patients in a local health center in Bahrain.

Detailed description: This is a double blinded RCT comparing the effect of insulin on wound healing in both diabetics and non diabetics.

The study will run in primary care setting in Bahrain. The aim of this study is to heal wound in an innovative way. and the Objective: to evaluate the effect of topical insulin administration on wound healing.

All adult patients with skin wounds attending primary health care center will be included in the study. Patients with acute and chronic wounds of the upper and lower extremities will be eligible to participate.

Eligibility criteria: Inclusion Criteria:

* Adult patients with Texas 1 and 2 wound criteria

Exclusion Criteria: Texas 3 and 4 wound criteria

-

Primary outcomes:
measure: Area of wound healing
timeFrame: 4 months
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
References:
citation: Xue Y, Reddy SK, Garza LA. Toward Understanding Wound Immunology for High-Fidelity Skin Regeneration. Cold Spring Harb Perspect Biol. 2022 Jul 1;14(7):a041241. doi: 10.1101/cshperspect.a041241.