Clinical trial NCT04215263: Risk Factors of POCD in General Anesthesia Patients Underwent Noncardiac and Non Neurological Procedures.
Official title: Risk Factors of Post Operative Cognitive Dysfunction (POCD) in General Anesthesia Patients Underwent Noncardiac and Non Neurological Procedures.
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Undergoing General Anaesthesia
Keywords: postoperative cognitive dysfunction
geriatrics
general anaesthesia
Lead sponsor: Indonesia University
Sponsor class: OTHER
First posted: 2020-01-02
Enrollment: 109
Sex: ALL
Minimum age (years): 60
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Geriatric patient (age over 60) underwent noncardiac non-neurological procedure under general anesthesia

Brief summary: The study was a prospective cohort study to assess the effect of age, duration of anesthesia, repeated surgery, and type of surgery on cognitive impairment in 108 geriatric patients (≥60 years) who underwent general anesthesia for non-neurologic noncardiac surgery.

Detailed description: The study was a prospective cohort study, assessing the effect of age, duration of anesthesia, repeated surgery, and type of surgery on cognitive impairment in 108 geriatric patients (≥60 years) who underwent general anesthesia for non-neurologic noncardiac surgery. The study used cognitive tests such as RAVLT, TMT, and Digit span tests. POCD definition is reduction in postoperative cognitive function by as much as 20% at a minimum of 2 cognitive tests.

Eligibility criteria: Inclusion Criteria:

* geriatric patient (age over 60) underwent noncardiac non-neurological procedure under general anesthesia
* patient can do reading and writing
* patient can speak in Bahasa
* signing informed consent

Exclusion Criteria:

* patient with cognitive impairment or psychiatric disorder such as delirium, amnesia, anxiety disorder, or depression.
* patient under psychotropic drugs or narcotics.
* patient with history of brain tumor, head injury or motoric disturbance and disability that can disturbed neurocognitive test

Primary outcomes:
measure: Mini International Neuropsychiatric Interview
timeFrame: 7 days
Secondary outcomes:
Other outcomes:
Locations:
city: Jakarta
country: Indonesia
facility: Indonesia University
state: DKI Jakarta
Study officials:
affiliation: Indonesia University
name: Aries Perdana, MD
role: PRINCIPAL_INVESTIGATOR
References:
citation: BEDFORD PD. Adverse cerebral effects of anaesthesia on old people. Lancet. 1955 Aug 6;269(6884):259-63. doi: 10.1016/s0140-6736(55)92689-1. No abstract available.
citation: Strom C, Rasmussen LS, Sieber FE. Should general anaesthesia be avoided in the elderly? Anaesthesia. 2014 Jan;69 Suppl 1(Suppl 1):35-44. doi: 10.1111/anae.12493.
citation: Rundshagen I. Postoperative cognitive dysfunction. Dtsch Arztebl Int. 2014 Feb 21;111(8):119-25. doi: 10.3238/arztebl.2014.0119.
citation: Canet J, Raeder J, Rasmussen LS, Enlund M, Kuipers HM, Hanning CD, Jolles J, Korttila K, Siersma VD, Dodds C, Abildstrom H, Sneyd JR, Vila P, Johnson T, Munoz Corsini L, Silverstein JH, Nielsen IK, Moller JT; ISPOCD2 investigators. Cognitive dysfunction after minor surgery in the elderly. Acta Anaesthesiol Scand. 2003 Nov;47(10):1204-10. doi: 10.1046/j.1399-6576.2003.00238.x.
citation: van Harten AE, Scheeren TW, Absalom AR. A review of postoperative cognitive dysfunction and neuroinflammation associated with cardiac surgery and anaesthesia. Anaesthesia. 2012 Mar;67(3):280-93. doi: 10.1111/j.1365-2044.2011.07008.x.