Clinical trial NCT03446339: Pulmonary Hypertension Screening for Rheumatology Patients (SOPHIE)
Official title: Territory-Wide Pulmonary Hypertension Screening Amongst Patients With Connective Tissue Diseases: A Prospective Screening Study
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Connective Tissue Diseases
Systemic Sclerosis
Systemic Lupus Erythematosus
Lead sponsor: The University of Hong Kong
Sponsor class: OTHER
First posted: 2018-02-26
Enrollment: 1800
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: CASE_ONLY
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: 1,800 rheumatology patients with connective tissue diseases from public hospitals within Hospital Authority of Hong Kong

Brief summary: Pulmonary arterial hypertension (PAH) is a serious and often fatal complication of connective tissue diseases including systemic sclerosis and systemic lupus erythematosus. It has been reported primarily from European series that the prevalence of PAH in patients with connective tissue diseases particularly systemic sclerosis is as high as 15-20%. However, given the paucity of medical literature in the area from Chinese population, the prevalence of PAH amongst Chinese patients with these conditions is largely unknown. Even worse, PAH is often undiagnosed amongst patients with connective tissue diseases due to the lack of awareness and/or access to echocardiography, which is a non-invasive first-line screening tool for PAH. As a result, most patients at diagnosis of PAH are at a relatively late stage, rendering pharmacological treatment less effective. Here, the investigators propose a territory-wide pulmonary hypertension screening for patients with connective tissue disease in order to (1) detect pulmonary hypertension amongst patients with connective tissue disease through systematic screening, and (2) understand the prevalence of pulmonary hypertension in Chinese patients with connective tissue diseases.

Detailed description: Objectives:

1. To detect pulmonary hypertension amongst patients with connective tissue diseases through systematic screening
2. To understand the prevalence of pulmonary hypertension in Chinese patients with connective tissue diseases

Study design:

The study is a territory-wide pulmonary hypertension screening project. Patients fulfilling the inclusion and exclusion criteria will undergo screen echocardiography as baseline to detect subclinical pulmonary hypertension.

Screening procedure:

Participants will undergo usual clinical assessment by the rheumatology teams of the parent hospitals including standard 12-lead ECG and 6-minute hall walk distance. then they will be referred to the Division of Cardiology, the Department of Medicine, the University of Hong Kong for (1) Echocardiography and (2) BNP (or pro-NT BNP) assay. The echocardiography will be performed based on the European Society of Cardiology (ESC)/European Respiratory Society (ERS) Guidelines. The echocardiographic probability of pulmonary hypertension will be determined (low, intermediate, and high).

Statistical analysis and power calculation:

There are no studies on which to calculate a power equation, because there are no previous reports on the prevalence of pulmonary hypertension in Chinese rheumatological patients. The sample size is based on our local prevalence of the rheumatological diseases.

Continuous variables will be expressed in mean ± SD. Statistical comparisons were performed using Student's t test or Fisher's exact test, as appropriate. The outcomes would be analyzed.

Eligibility criteria: Inclusion Criteria:

* Patientw with either (1) systemic lupus erythematosus, (2) systemic sclerosis, or (3) other connective tissue diseases at risk of pulmonary hypertension
* Voluntarily agrees to participate by providing written informed consent
* Age ≥ 18 at enrolment

Exclusion Criteria:

- Refuse to participate the study

Primary outcomes:
measure: Prevalence of asymptomatic pulmonary hypertension in Chinese patients with connective tissue diseases
timeFrame: 36 months
Secondary outcomes:
measure: Clinical predictor of Echocardiography for pulmonary hypertension in Chinese patients with connective tissue diseases
timeFrame: 36 months
measure: Clinical predictor of BNP assay for pulmonary hypertension in Chinese patients with connective tissue diseases
timeFrame: 36 months
Other outcomes:
Locations:
city: Hong Kong
country: China
facility: The University of Hong Kong
Study officials:
affiliation: The Universtiy of Hong Kong
name: David Chung-Wah Siu, Professor
role: PRINCIPAL_INVESTIGATOR
References: