Clinical trial NCT06777134: Relationship Between Pelvic Floor Dysfunctions and Lower Limb Strength and Activation in MS Patients
Official title: Relationship Between Pelvic Floor Dysfunctions and Core Endurance, Hip Rotation Muscle Strength, Tibialis Anterior and Tibialis Posterior Muscle Activation in Patients with Multiple Sclerosis
Study type: OBSERVATIONAL
Overall status: ENROLLING_BY_INVITATION
Conditions: Multiple Sclerosis
Pelvic Floor Dysfunction
Keywords: pelvic floor
multiple sclerosis
core endurance
tibialis anterior
tibialis posterior
electromyography
Lead sponsor: Biruni University
Sponsor class: OTHER
First posted: 2025-01-15
Enrollment: 73
Sex: FEMALE
Minimum age (years): 18
Maximum age (years): 65
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: CASE_ONLY
Time perspective: CROSS_SECTIONAL
Sampling method: NON_PROBABILITY_SAMPLE
Study population: It is planned to include 73 patients who applied to Bakırköy Prof. Dr. Mazhar Osman Mental and Nervous Diseases Training and Research Hospital Neurology Clinic and who were diagnosed with definite Multiple Sclerosis according to McDonald Diagnostic Criteria with EDSS level between 0-4.

Brief summary: we aim to investigate the relationship between pelvic floor dysfunctions, core endurance, hip external rotation muscle strength, and tibialis posterior and tibialis anterior muscle activation in patients diagnosed with MS


Eligibility criteria: Inclusion Criteria:

* EDSS score between 0 and 4.0
* Having access to the internet via a high-speed smartphone or computer
* Scoring at least 21 points on the MoCA
* Having a score of Stage 3 or higher on the Functional Ambulation Scale.

Exclusion Criteria:

* Having hearing or vision problems.
* Participating in any exercise program.
* Having accompanying other neurological, cardiovascular, or orthopedic disorders.
* A history of an MS relapse or medication change within the last 6 months.
* Being in a physical condition that prevents participation in exercises.
* Comorbid conditions that negatively affect oxygen transport (e.g., severe anemia, peripheral artery disease, etc.)

Primary outcomes:
measure: Pelvic floor muscle dysfunction
timeFrame: baseline
Secondary outcomes:
measure: Qualitf of life
timeFrame: Baseline
measure: Core endurance -trunk flexor endurance
timeFrame: baseline
measure: Core endurance -trunk extansor endurance
timeFrame: baseline
measure: Core endurance - lateral flexor endurance
timeFrame: baseline
measure: Hip strength
timeFrame: baseline
measure: tibialis posterior muscle activation - peak torque
timeFrame: baseline
measure: tibialis posterior muscle activation - work avarage
timeFrame: baseline
measure: tibialis posterior muscle activation - percentage of maximal voluntary contractions
timeFrame: baseline
measure: tibialis posterior muscle activation - rest tone
timeFrame: baseline
measure: tibialis anterior muscle activation - peak torque
timeFrame: baseline
measure: tibialis anterior muscle activation - work avarage
timeFrame: baseline
measure: tibialis anterior muscle activation - percentage of maximal voluntarily contractions
timeFrame: baseline
measure: tibialis anterior muscle activation - rest tone
timeFrame: baseline
Other outcomes:
Locations:
city: İ̇stanbul
country: Turkey
facility: Biruni University
Study officials:
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