Clinical trial NCT06607965: Whey Protein and Carbohydrates in ERAS for Recovery After Thyroidectomy: A Cohort Study
Official title: Effects of Whey Protein Combined With Carbohydrates in the ERAS Protocol on the Recovery of Thyroid Cancer Patients After Lateral Neck Dissection: A Prospective Cohort Study
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Whey Protein
Thyroid Neoplasms
Neck Dislocation
Enhanced Recovery After Surgery
Lead sponsor: Chongqing General Hospital
Sponsor class: OTHER
First posted: 2024-09-23
Enrollment: 127
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: SUPPORTIVE_CARE

Brief summary: Exploring the effects of whey protein combined with carbohydrates in an Enhanced Recovery After Surgery (ERAS) protocol on the postoperative recovery of thyroid cancer patients undergoing lateral neck dissection, aiming to provide more precise research and guidance for the perioperative accelerated recovery plan in such patients. The goal is to accelerate postoperative recovery and reduce postoperative complications for thyroid cancer patients undergoing neck dissection.

Detailed description: Perioperative dietary management was differentiated between the two groups:

Experimental Group:

6 hours before surgery, patients orally consumed 250 ml of a full-nutrition liquid (220 ml homogenized diet, 50 g; containing 31.4 g carbohydrates, 8 g protein, and 215 kcal).

2 hours before surgery, patients orally consumed 200 ml of a clear liquid (50 g enzymatically hydrolyzed rice powder + 0.5 g low-sodium salt; containing 47.7 g carbohydrates, 6.5 g whey protein, and 193 kcal).

After surgery, once there were no symptoms such as dizziness or vomiting, patients could start consuming clear liquids (containing 47.7 g carbohydrates, 6.5 g protein, and 221 kcal) orally every 30 minutes, 4 times on the day of surgery.

Starting from the first day after surgery, patients consumed 200 ml of fat-free nutritional liquid (50 g enzymatically hydrolyzed rice powder + 7.5 g isolated whey protein + 0.5 g low-sodium salt; 223 kcal) per serving, 4 to 6 times per day as needed.

Control Group:

Patients fasted for 12 hours before surgery, and after surgery, intravenous fluids were administered. Fat-free diet began after 24 hours post-surgery.

Discharge Criteria: The discharge time was determined by the surgeon based on the patient's postoperative drainage condition and the presence or absence of complications.

Eligibility criteria: Inclusion Criteria:

* Aged 18 years or older;
* Differentiated thyroid cancer with lateral lymph node dissection;
* Written informed consent provided by the participant.

Exclusion Criteria:

* History of chronic liver or kidney disease, ischemic heart disease, or diabetes;
* Previous neck surgery or history of iodine-131 radiation;
* Allergy to soy or whey protein;
* Intraoperative chylous leak;
* Other special types of thyroid cancer.

Primary outcomes:
measure: hemoglobin
timeFrame: 3 day
measure: serum albumin
timeFrame: 3 day
measure: Postoperative Complication
timeFrame: 1 month
measure: weight
timeFrame: 1week
Secondary outcomes:
Other outcomes:
Locations:
city: Chongqing
country: China
facility: Chongqing General Hospital
state: Chongqing
Study officials:
References: