Clinical trial NCT05781230: The Effect of Exercises of Different Intensity Applied After Total Knee Arthroplasty on Exercise-Induced Hypoalgesia
Official title: The Effect of Exercises of Different Intensity Applied After Total Knee Arthroplasty on Exercise-Induced Hypoalgesia: Randomised Controlled Trial
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Knee Osteoarthritis
Pain, Acute
Keywords: Total Knee Arthroplasty
Exercises intensity
pressure pain threshold
exercise-induced hypoalgesia
Lead sponsor: Hacettepe University
Sponsor class: OTHER
First posted: 2023-03-23
Enrollment: 38
Sex: ALL
Minimum age (years): 18
Maximum age (years): 65
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The aim of this study was to investigate whether exercise-induced hypoalgesia (EIH) is present following exercise in patient after total knee arthroplasty (TKA) and if so, if it changes with exercise intensity. A repeated measures and single-blinded randomized study were done. Thirty-eight patients 24 hours after TKA were randomly assigned to either low intensity exercises (LIE) group or high intensity exercises (HIE) group. An exercise programs lasted for five days during the hospitalization period. Pain severity was assessed by Visual Analog Scale (VAS) (0-10 mm). Pressure pain thresholds (PPTs) were measured over quadriceps and biceps brachii and muscles immediately before and after exercise.

Detailed description: Background: The aim of this study was to investigate whether exercise-induced hypoalgesia (EIH) is present following exercise in patient after total knee arthroplasty (TKA) and if so, if it changes with exercise intensity.

Methods : A repeated measures and single-blinded randomized study were done. Thirty-eight patients 24 hours after TKA were randomly assigned to either low intensity exercises (LIE) group or high intensity exercises (HIE) group. An exercise programs lasted for five days during the hospitalization period. Pain severity was assessed by Visual Analog Scale (VAS) (0-10 mm). Pressure pain thresholds (PPTs) were measured over quadriceps and biceps brachii and muscles immediately before and after exercise.

Eligibility criteria: Inclusion Criteria:

* Patients had undergone primary unilateral total knee replacement surgery
* Patients hospitalized for at least seven days were enrolled in this study.

Exclusion Criteria:

* Medically stable patients who used glucocorticoids or strong analgesic drugs
* Patients had post-traumatic OA, rheumatoid arthritis (RA), psoriatic arthritis, cognitive, hearing and visual problems Patients were diagnosed chronic pain condition were excluded from the study.

Primary outcomes:
measure: change of pain severity
timeFrame: admission to hospital service to discharge from hospital service, an average 5 days
measure: Change of Pressure pain theshold
timeFrame: admission to hospital service to discharge from hospital service, an average 5 days
Secondary outcomes:
Other outcomes:
Locations:
city: Isparta
country: Turkey
facility: Merve Karapinar
Study officials:
affiliation: RESEARCH ASSİSSTANT
name: MERVE KARAPINAR, PT
role: PRINCIPAL_INVESTIGATOR
References: