Clinical trial NCT02550496: Evaluation of Trichoscopy in the Diagnosis of Tinea Capitis
Official title: Evaluation of Trichoscopy in the Diagnosis of Tinea Capitis. Prospective, Multicenter Study (ETDT)
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Tinea Capitis
Lead sponsor: Centre Hospitalier Universitaire, Amiens
Sponsor class: OTHER
First posted: 2015-09-15
Enrollment: 104
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: DIAGNOSTIC

Brief summary: Waiting for a proof by mycological culture is usually necessary before starting a systemic antifungal therapy. It therefore seems to us interesting to evaluate the benefit of using dermoscopy in clinical diagnosis of Tinea Capitis.


Eligibility criteria: Inclusion Criteria:

* All patients with clinically diagnosed tinea capitis
* Patient has signed informed consent

Exclusion Criteria:

* Patient with kerion or tinea favosa
* Antifungal treatment within 15 days prior to inclusion

Primary outcomes:
measure: The presence of several hair with at least one dermoscopic appearance specific of tinea capitis
timeFrame: baseline
Secondary outcomes:
measure: Dermoscopic appearance (corkscrew hair, comma hairs, interrupted (Morse code-like) hairs, hair shafts covered by whitish sheaths, zig-zag shaped hairs) according to microscopic pathogenic species.
timeFrame: baseline
measure: Concordance of dermoscopic appearance for each of the two operators.
timeFrame: baseline
measure: Presence of a green fluorescence or not under the light of a Wood's lamp by comparing it with the result of the fungal culture.
timeFrame: baseline
measure: Introduction or not of a local or general presumptive treatment by the clinician while waiting for the result of the fungal culture.
timeFrame: baseline
Other outcomes:
Locations:
city: Amiens
country: France
facility: CHU Amiens
state: Picardie
city: Caen
country: France
facility: CHU Caen
city: Lille
country: France
facility: CHRU Lille
city: Rouen
country: France
facility: CHU Rouen
Study officials:
affiliation: CHU Amiens, Service de Dermatologie
name: Catherine Lok, PU-PH
role: PRINCIPAL_INVESTIGATOR
References:
citation: Zalaudek I, Argenziano G, Di Stefani A, Ferrara G, Marghoob AA, Hofmann-Wellenhof R, Soyer HP, Braun R, Kerl H. Dermoscopy in general dermatology. Dermatology. 2006;212(1):7-18. doi: 10.1159/000089015.
citation: Micali G, Lacarrubba F, Massimino D, Schwartz RA. Dermatoscopy: alternative uses in daily clinical practice. J Am Acad Dermatol. 2011 Jun;64(6):1135-46. doi: 10.1016/j.jaad.2010.03.010. Epub 2011 Feb 3.
citation: Ekiz O, Sen BB, Rifaioglu EN, Balta I. Trichoscopy in paediatric patients with tinea capitis: a useful method to differentiate from alopecia areata. J Eur Acad Dermatol Venereol. 2014 Sep;28(9):1255-8. doi: 10.1111/jdv.12246. Epub 2013 Aug 24.
citation: Hughes R, Chiaverini C, Bahadoran P, Lacour JP. Corkscrew hair: a new dermoscopic sign for diagnosis of tinea capitis in black children. Arch Dermatol. 2011 Mar;147(3):355-6. doi: 10.1001/archdermatol.2011.31. No abstract available.
citation: Sandoval AB, Ortiz JA, Rodriguez JM, Vargas AG, Quintero DG. [Dermoscopic pattern in tinea capitis]. Rev Iberoam Micol. 2010 Sep 30;27(3):151-2. doi: 10.1016/j.riam.2010.02.003. Epub 2010 Mar 24. No abstract available. Spanish.
citation: Slowinska M, Rudnicka L, Schwartz RA, Kowalska-Oledzka E, Rakowska A, Sicinska J, Lukomska M, Olszewska M, Szymanska E. Comma hairs: a dermatoscopic marker for tinea capitis: a rapid diagnostic method. J Am Acad Dermatol. 2008 Nov;59(5 Suppl):S77-9. doi: 10.1016/j.jaad.2008.07.009.