Clinical trial NCT05231915: Prevalence of the c.853delT Mutation of the HOXB13 Gene in Prostate Cancer in Martinique
Official title: Prevalence of the c.853delT Mutation of the HOXB13 Gene in Prostate Cancer in Martinique
Study type: INTERVENTIONAL
Overall status: RECRUITING
Phase: NA
Conditions: Prostate Cancer
Keywords: Prostate cancer
Martinique
HOXB13 c.853delT prevalence
Lead sponsor: University Hospital Center of Martinique
Sponsor class: OTHER
First posted: 2022-02-09
Enrollment: 465
Sex: MALE
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: SCREENING

Brief summary: In Martinique, prostate cancer incidence rates are nowadays among the highest worldwide with a high incidence of early-onset and familial forms. We identified a rare heterozygous germline variant c.853delT (p.Ter285Lysfs) rs77179853, reported only among patients of African ancestry with a minor allele frequency of 3.2%. We search to estimate the prevalence of this variant in a sample of prevalent prostate cancer cases managed in urology consultation in Martinique .

Detailed description: In Martinique, prostate cancer incidence rates are nowadays among the highest worldwide with a high incidence of early-onset and familial forms. Despite the demonstration of a strong familial component, identification of the genetic basis for hereditary prostate cancer is challenging. The screening of the HOXB13 gene is recommended for men who develop an early-onset and/or familial Pca . In fact, the HOXB13 germline variant G84E (rs138213197) was described in men of European descent with prostate cancer risk. Other germline variants were detected in ethnic groups. More recently, we reported a rare HOXB13 mutation, specifically c.853delT (pTer285Lysfs) that appears to be contribute to young Prostate Cancer cases in Martinique. This variant is a stop loss reported only among patients of African ancestry .

Regarding the allele frequency of the HOXB13 c.853delT variant observed in the Pca cohort, it will be necessary to assess relative and absolute Pca risks for HOXB13 c.853delT carriers. This information is essential to use this variant in genetic counseling. We propose to sequence the HOXB13 gene of all prostate cancers cases managed in urology consultation in Martinique.

Eligibility criteria: Inclusion Criteria:

* Adult man over 18 years of age living in Martinique with a prostate cancer whatever the histological type and the stage, managed in urology consultation (public and private sectors of Martinique)
* Sporadic or familial form
* Informed with a written consent signed by the participant and the investigator
* Affiliate or beneficiary of french social security.

Exclusion Criteria:

* Patient who is not of African descent
* Refusal to participate.
* Patients not affiliated to french social security

Primary outcomes:
measure: Estimation of prevalence of Allelic frequency of the HOXB13 c.853delT mutation
timeFrame: At baseline
Secondary outcomes:
Other outcomes:
Locations:
city: Fort-de-France
country: Martinique
facility: Centre Hospitalier Universitaire de Martinique
Study officials:
References: