Clinical trial NCT02923219: The Clinical Application of Adipose-Derived Stem Cells on Facial Rejuvenation
Official title: The Clinical Application of Adipose-Derived Stem Cells on Facial Rejuvenation
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Facies
Keywords: Facial Rejuvenation
Adipose-Derived Stem Cells
Lead sponsor: Xuzhou Medical University
Sponsor class: OTHER
First posted: 2016-10-04
Enrollment: 50
Sex: ALL
Minimum age (years): 18
Maximum age (years): 60
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: TREATMENT

Brief summary: The purpose of this study is to determine whether the adipose-derived stem cells therapy is effective in the treatment of facial rejuvenation.

Detailed description: This study will be a prospective study of patients who undergo adipose-derived stem cells therapy for facial rejuvenation at the hospital of Xuzhou medical university. The therapy involves injection of patient's own adipose-derived stem cells, which are separated from vacuumed fat obtained through liposuction of abdomen, hip, thigh and so on. It was confirmed the adipose-derived stem cells can be induced differentiation into fat cells, osteoblasts, chondrocytes, muscle cells, endothelial cells and so on under the corresponding condition in the current literature. The therapy has evolved as a less invasive technique for facial rejuvenation compared to more traditional techniques，such as fat cells injection, sodium hyaluronate injection. Through the use of pre and post treatment photos, three-dimensional skin CT, in addition to the therapeutic evaluation, patient satisfaction questionnaire and a clinician assessment, it is our hope that the investigators will confirm the rejuvenating capabilities of adipose-derived stem cells therapy.

Eligibility criteria: Inclusion Criteria:

* Males and females
* Ages18-60
* Patients of all racial and ethnic origins
* Patients of all undergoing facial rejuvenation

Exclusion Criteria:

* Ages under 18, and above 60
* Female patients in pregnancy or menstrual period
* Patients undergoing facial rejuvenation using other methods including botox injections, chemical peels, face lifts and others
* Patients using blood thinners, aspirin and hormone, that cannot be stopped
* Patients suffering with severe organic disease, such as coronary heart disease, hypertension, diabetes, lung dysfunction and so on
* Patients suffering with mental disease, and acute or chronic infectious diseases

Primary outcomes:
measure: The therapeutic evaluation of adipose-derived stem cells or fat cells solely on facial rejuvenation
timeFrame: 1,3 and 6 Months Post-Surgery
Secondary outcomes:
measure: The therapeutic evaluation of adipose-derived stem cells combined with fat cells on facial rejuvenation
timeFrame: 1,3 and 6 Months Post-Surgery
Other outcomes:
Locations:
Study officials:
affiliation: the Affiliated Hospital of the XuZhou Medical University
name: Jin Peisheng
role: PRINCIPAL_INVESTIGATOR
References:
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citation: Li Q, Zhang A, Tao C, Li X, Jin P. The role of SDF-1-CXCR4/CXCR7 axis in biological behaviors of adipose tissue-derived mesenchymal stem cells in vitro. Biochem Biophys Res Commun. 2013 Nov 22;441(3):675-80. doi: 10.1016/j.bbrc.2013.10.071. Epub 2013 Oct 30.
citation: Yin Y, Li J, Li Q, Zhang A, Jin P. Autologous fat graft assisted by stromal vascular fraction improves facial skin quality: A randomized controlled trial. J Plast Reconstr Aesthet Surg. 2020 Jun;73(6):1166-1173. doi: 10.1016/j.bjps.2019.11.010. Epub 2019 Nov 29.