Clinical trial NCT05088486: The Role of Genetic Factors in the Development of Arterial Hypertension in the Kazakh Population
Official title: Preventive and Personalized Medicine (2021-2023)
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Arterial Hypertension
Keywords: GWAS
Lead sponsor: Asfendiyarov Kazakh National Medical University
Sponsor class: OTHER
First posted: 2021-10-22
Enrollment: 1200
Sex: ALL
Minimum age (years): 18
Maximum age (years): 55
Standard ages: ADULT
Observational model: OTHER
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: patients with arterial hypertension of Kazakh nationality

Brief summary: This is a GWAS study that aims to identify possible candidate genes associate to arterial hypertension by exploring single nucleotide polymorphism (SNP) in a group of arterial hypertension, in the Kazakh population. The investigators hypothesize that the careful phenotyping of the subject sand matching with increase the power to find SNP significantly associate with arterial hypertension

Detailed description: A genome-wide association study (GWAS) is an approach used in genetics research to associate specific genetic variations with particular diseases. The method involves scanning the genomes from many different people and looking for genetic markers that can be used to predict the presence of a disease. Once such genetic markers are identified, they can be used to understand how genes contribute to the disease and develop better prevention and treatment strategies.

Eligibility criteria: Inclusion Criteria:

* Persons with confirmed arterial hypertension;
* The age of patients is from 18 to 55 years old inclusive;
* Persons of Kazakh nationality, whose paternal and maternal grandparents identify themselves as Kazakhs;
* Persons who are able and willing to provide written informed consent;
* Persons capable and willing to comply with the research protocol;

Exclusion Criteria:

* Persons under 18 and over 55;
* Persons who, in the opinion of the researcher, are mentally or legally incapacitated, which prevents obtaining informed consent;
* Pregnant or lactating women;
* Tuberculosis of any localization in the active phase and in history;
* Severe and decompensated diseases of the liver and kidneys, cardiovascular system;
* Severe and decompensated course of endocrine diseases;
* Autoimmune diseases;
* Systemic diseases;
* Cancer.

Primary outcomes:
measure: number of SNPs associated with arterial hypertension
timeFrame: 1 year
Secondary outcomes:
Other outcomes:
Locations:
city: Almaty
country: Kazakhstan
facility: Deputy head of Gerontology Center of Medical Centre Hospital of the President's Affairs Administration of the Republic of Kazakhstan
Study officials:
affiliation: Deputy head of Gerontology Center of Medical Centre Hospital of the President's Affairs Administration of the Republic of Kazakhstan
name: Raushan Karibayeva, Doctor of medical sciences
role: STUDY_DIRECTOR
affiliation: Deputy head of Gerontology Center of Medical Centre Hospital of the President's Affairs Administration of the Republic of Kazakhstan
name: Tamara Vochshenkova, MBA
role: STUDY_CHAIR
References: