Clinical trial NCT06809309: The Ventilation During In-hospital Cardiac Arrest Study
Official title: The Ventilation During In-Hospital Cardiac Arrest (VENT-IHCA) Study
Study type: OBSERVATIONAL
Overall status: RECRUITING
Conditions: Cardiac Arrest (CA)
In-Hospital Cardiac Arrest
Heart Arrest
Keywords: prospective observational study
ventilation
manual ventilation
cardiac arrest
in-hospital cardiac arrest (IHCA)
bag-valve-mask (BVM)
tidal volume
ventilation rate
intra-arrest ventilation
cardiopulmonary ventilation (CPR)
resuscitation
adult
Lead sponsor: University of Aarhus
Sponsor class: OTHER
First posted: 2025-02-05
Enrollment: 900
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Adult patients receiving ventilation with a bag-valve-mask (BVM) or advanced airway during cardiopulmonary resuscitation for in-hospital cardiac arrest.

Brief summary: The goal of this prospective observational study is to learn how ventilation quality parameters during cardiopulmonary resuscitation (CPR) are associated with short-term survival following in-hospital cardiac arrest of adult patients.

The main questions it aims to answer are:

What ventilation volume during CPR is associated with the highest chance of return of spontaneous circulation (ROSC)? What ventilation rate during CPR is associated with the highest chance of ROSC?

Researchers will compare different levels of ventilation rates and volumes that are blindly measured during CPR to see how the observed rates and volumes are associated with survival outcomes and complications.


Eligibility criteria: Inclusion Criteria:

1. In-hospital cardiac arrest
2. Age ≥ 18 years
3. \>1minute of recorded ventilation data

Exclusion Criteria:

1. Documented do-not-attempt cardiopulmonary resuscitation order
2. Invasive mechanical circulatory support at the time of the cardiac arrest

Primary outcomes:
measure: Fraction of patients with return of spontaneous circulation (ROSC)
timeFrame: ROSC is assessed immediately following cardiopulmonary resuscitation.
Secondary outcomes:
measure: Fraction of patients surviving until day 30
timeFrame: Assessed at day 30 after cardiac arrest.
Other outcomes:
measure: Fraction of patients with pulmonary complications
timeFrame: From date of ROSC until date of intensive care unit discharge or date of death from any cause, whichever came first, assessed up to 30 days.
measure: Number of days alive without mechanical ventilation
timeFrame: From date of ROSC until day 30 or date of death from any cause, whichever came first.
measure: Number of days alive outside the intensive care unit
timeFrame: From date of ROSC until day 90 or date of death from any cause, whichever came first.
Locations:
city: Aalborg
country: Denmark
facility: Aalborg University Hospital
city: Gødstrup
country: Denmark
facility: Gødstrup Regional Hospital
city: Horsens
country: Denmark
facility: Horsens Regional Hospital
city: Odense
country: Denmark
facility: Odense University Hospital
city: Randers
country: Denmark
facility: Randers Regional Hospital
city: Viborg
country: Denmark
facility: Viborg Regional Hospital
Study officials:
affiliation: Department of Clinical Medicine, Aarhus University, Denmark; Department of Medicine, Randers Regional Hospital, Randers, Denmark; Research Center for Emergency Medicine, Aarhus University Hospital, Denmark
name: Johannes Wittig, MD
role: PRINCIPAL_INVESTIGATOR
affiliation: Department of Clinical Medicine, Aarhus University, Denmark; Department of Medicine, Randers Regional Hospital, Randers, Denmark; Research Center for Emergency Medicine, Aarhus University Hospital, Denmark;
name: Kasper G Lauridsen, MD, PhD
role: PRINCIPAL_INVESTIGATOR
References: