Clinical trial NCT06097260: Randomized, Double-blind Study of Efficacy and Safety of Bexotegrast (PLN-74809) for Idiopathic Pulmonary Fibrosis
Official title: A Randomized, Double-blind, Dose-ranging, Placebo-controlled Study to Evaluate the Efficacy and Safety of Bexotegrast (PLN-74809) for the Treatment of Idiopathic Pulmonary Fibrosis (BEACON-IPF)
Study type: INTERVENTIONAL
Overall status: ACTIVE_NOT_RECRUITING
Phase: PHASE2
Conditions: Idiopathic Pulmonary Fibrosis
Keywords: IPF
idiopathic pulmonary fibrosis
pulmonary fibrosis
bexotegrast
Beacon
BEACON-IPF
Lead sponsor: Pliant Therapeutics, Inc.
Sponsor class: INDUSTRY
First posted: 2023-10-24
Enrollment: 360
Sex: ALL
Minimum age (years): 40
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: A randomized, double-blind, dose-ranging, placebo-controlled study to evaluate the efficacy and safety of bexotegrast (PLN-74809) for the treatment of idiopathic pulmonary fibrosis (BEACON-IPF).

Detailed description: This is a randomized, double-blind, dose-ranging, placebo-controlled study to evaluate the efficacy and safety of 2 doses of bexotegrast (PLN-74809) \[160 and 320 mg\] taken for 52 weeks by participants with IPF taking and not taking background therapy (ie, nintedanib or pirfenidone).

The study will consist of an up to 35-day Screening Period, a 52-week Treatment Period, and a 14 day Safety Follow-up Period. Of note, participants who are not taking background therapy at study entry will be allowed to initiate it at any time during the study.

Eligibility criteria: Inclusion Criteria:

1. ≥ 40 years of age prior to screening
2. IPF diagnosis ≤ 7 years prior to screening
3. FVCpp ≥ 45%
4. Diffusing capacity for carbon monoxide percent predicted (hemoglobin-adjusted) ≥ 30% and \< 90%
5. Current treatment for IPF with background therapy is allowed, if at a stable dose for ≥ 12 weeks prior to screening
6. If not currently receiving treatment for IPF (either treatment naïve or discontinued prior treatment), participant must not have taken background therapy for at least 8 weeks prior to screening

Exclusion Criteria:

1. Receiving pharmacologic therapy for pulmonary hypertension
2. Self-reported smoking of any kind (not limited to tobacco)
3. History of malignancy within the past 5 years or ongoing malignancy other than basal cell carcinoma, resected noninvasive cutaneous squamous cell carcinoma, or treated cervical carcinoma in situ
4. Hepatic impairment or end-stage liver disease
5. Renal impairment or end-stage kidney disease requiring dialysis
6. Pregnant or lactating female participant
7. Uncontrolled systemic arterial hypertension
8. Receiving any unapproved or investigational agent intended for treatment of fibrosis in IPF
9. Prior administration of bexotegrast
10. Likely to have lung transplantation during the study (being on transplantation list is not an exclusion)
11. Forced expiratory volume in the first second (FEV1)/FVC ratio \<0.7 at screening
12. Clinical evidence of active infection, including, but not limited to bronchitis, pneumonia, or sinusitis that can affect FVC measurement during screening or at randomization
13. Known acute IPF exacerbation, or suspicion by the Investigator of such, 6 months prior to screening

Primary outcomes:
measure: To characterize the effect of bexotegrast versus placebo on the change in forced vital capacity (FVC) in participants with idiopathic pulmonary fibrosis (IPF)
timeFrame: 52 weeks
Secondary outcomes:
measure: To characterize the effect of bexotegrast versus placebo over 52 weeks of treatment on disease progression
timeFrame: Up to 52 weeks
measure: Time to disease progression defined as
timeFrame: Up to 52 weeks
measure: Proportion of participants with disease progression defined as
timeFrame: Up to 52 weeks
measure: To characterize the effect of bexotegrast versus placebo on the change in FVC in participants with and without background therapy at baseline with IPF
timeFrame: 52 weeks
measure: Change from baseline in Living with Pulmonary Fibrosis (L-PF) Dyspnoea and Cough Domain score
timeFrame: 52 Weeks
measure: Change from baseline in King's Brief Interstitial Lung Disease (K-BILD) questionnaire Total score
timeFrame: 52 Weeks
measure: To characterize the effect of bexotegrast versus placebo on change in lung fibrosis by high-resolution computed tomography
timeFrame: 52 Weeks
measure: To characterize the safety and tolerability of bexotegrast versus placebo in participants with IPF
timeFrame: Up to 52 weeks
measure: To characterize the safety and tolerability of bexotegrast versus placebo in participants with IPF over 52 weeks of treatment
timeFrame: Over 52 Weeks
Other outcomes:
Locations:
city: Birmingham
country: United States
facility: University of Alabama at Birmingham
state: Alabama
city: Phoenix
country: United States
facility: Arizona Pulmonary Specialists
state: Arizona
city: Phoenix
country: United States
facility: Dignity Health-St. Josephs Hospital and Medical Center
state: Arizona
city: Tucson
country: United States
facility: University of Arizona College of Medicine
state: Arizona
city: Los Angeles
country: United States
facility: University of Southern California - Keck School of Medicine
state: California
city: Los Angeles
country: United States
facility: Cedars Sinai Medical Center
state: California
city: Newport Beach
country: United States
facility: Newport Native MD, Inc
state: California
city: Palm Springs
country: United States
facility: Palmtree Clinical Research
state: California
city: Palo Alto
country: United States
facility: VA Palo Alto Health Care System
state: California
city: Redding
country: United States
facility: Paradigm Clinical Research Institute Inc - ClinEdge
state: California
city: Sacramento
country: United States
facility: University of California Davis Comprehensive Cancer Center
state: California
city: San Francisco
country: United States
facility: UCSF Medical Center - Pulmonary Practice
state: California
city: Santa Barbara
country: United States
facility: Jeffrey S. Sager, MD Medical Corporation
state: California
city: Stanford
country: United States
facility: Stanford Health Care
state: California
city: Aurora
country: United States
facility: University of Colorado
state: Colorado
city: Denver
country: United States
facility: National Jewish Health Main Campus
state: Colorado
city: Lakewood
country: United States
facility: Critical Care, Pulmonary and Sleep Associates
state: Colorado
city: Danbury
country: United States
facility: Nuvance Health Medical Practices, Pulmonary & Sleep Specialists
state: Connecticut
city: New Haven
country: United States
facility: Yale New Haven Hospital - York Street Campus
state: Connecticut
city: Washington
country: United States
facility: MedStar Georgetown University Hospital
state: District of Columbia
city: Gainesville
country: United States
facility: Malcom Randall VA Medical Center
state: Florida
city: Jacksonville
country: United States
facility: Mayo Clinic Jacksonville
state: Florida
city: Kissimmee
country: United States
facility: Clinical Research Specialists, LLC
state: Florida
city: Leesburg
country: United States
facility: Clinical Site Partners - Leesburg
state: Florida
city: Orlando
country: United States
facility: Central Florida Pulmonary Group PA
state: Florida
city: Tampa
country: United States
facility: GCP Clinical Research
state: Florida
city: Atlanta
country: United States
facility: Emory Clinic
state: Georgia
city: Augusta
country: United States
facility: Augusta University
state: Georgia
city: Chicago
country: United States
facility: Northwestern Memorial Hospital
state: Illinois
city: Maywood
country: United States
facility: Loyola University Medical Center
state: Illinois
city: Indianapolis
country: United States
facility: IU Health Advanced Heart and Lung Care
state: Indiana
city: Kansas City
country: United States
facility: University of Kansas Medical Center
state: Kansas
city: Lexington
country: United States
facility: Lexington VA Medical Center
state: Kentucky
city: Louisville
country: United States
facility: Norton Pulmonary Specialists
state: Kentucky
city: New Orleans
country: United States
facility: Tulane Medical Center
state: Louisiana
city: Baltimore
country: United States
facility: University of Maryland Medical Center
state: Maryland
city: Baltimore
country: United States
facility: The Johns Hopkins Hospital JHH
state: Maryland
city: Boston
country: United States
facility: Massachusetts General Hospital - Pulmonary Associates
state: Massachusetts
city: Boston
country: United States
facility: Brigham and Womans Hospital
state: Massachusetts
city: Boston
country: United States
facility: Beth Israel Deaconess Medical Cente
state: Massachusetts
city: North Dartmouth
country: United States
facility: Infinity Medical Research
state: Massachusetts
city: Ann Arbor
country: United States
facility: University of Michigan Health System
state: Michigan
city: Detroit
country: United States
facility: Henry Ford Health System
state: Michigan
city: Minneapolis
country: United States
facility: University of Minnesota Medical Center, Fairview
state: Minnesota
city: Rochester
country: United States
facility: Mayo Clinic
state: Minnesota
city: Chesterfield
country: United States
facility: The Lung Research Center
state: Missouri
city: Lebanon
country: United States
facility: Dartmouth Hitchcock Medical Center
state: New Hampshire
city: Bronx
country: United States
facility: Montefiore Medical Center Moses Division Hospital
state: New York
city: New York
country: United States
facility: Icahn School of Medicine at Mount Sinai
state: New York
city: New York
country: United States
facility: New York Presbyterian Hospital-Columbia University Medical Center
state: New York
city: New York
country: United States
facility: Weill Cornell Medicine
state: New York
city: Durham
country: United States
facility: Duke University Medical Center
state: North Carolina
city: Greensboro
country: United States
facility: PulmonIx, LLC
state: North Carolina
city: Winston-Salem
country: United States
facility: Southeastern Research Center
state: North Carolina
city: Cincinnati
country: United States
facility: University of Cincinnati
state: Ohio
city: Cleveland
country: United States
facility: The Cleveland Clinic Foundation
state: Ohio
city: Oklahoma City
country: United States
facility: OU Health Physicians
state: Oklahoma
city: Bend
country: United States
facility: Bend Memorial Clinic/Summit Medical Group - Eastside
state: Oregon
city: Portland
country: United States
facility: Legacy Good Samaritan Hospital
state: Oregon
city: DuBois
country: United States
facility: Clinical Research Associates Of Central PA , LLC
state: Pennsylvania
city: Hershey
country: United States
facility: Penn State Health Milton S. Hershey Medical Center
state: Pennsylvania
city: Philadelphia
country: United States
facility: Perelman Center for Advanced Medicine
state: Pennsylvania
city: Pittsburgh
country: United States
facility: University of Pittsburgh Medical Center
state: Pennsylvania
city: Charleston
country: United States
facility: Medical University of South Carolina
state: South Carolina
city: Greenville
country: United States
facility: Velocity Clinical Research
state: South Carolina
city: North Charleston
country: United States
facility: Lowcountry Lung and Critical Care PA
state: South Carolina
city: Franklin
country: United States
facility: Clinical Trials Center of Middle Tennessee
state: Tennessee
city: Knoxville
country: United States
facility: Statcare Pulmonary Consultants - Knoxville
state: Tennessee
city: Knoxville
country: United States
facility: University of Tennessee Medical Center
state: Tennessee
city: Nashville
country: United States
facility: Vanderbilt University Medical Center
state: Tennessee
city: Dallas
country: United States
facility: Baylor Scott and White Health - Advanced Lung Disease Specialists
state: Texas
city: El Paso
country: United States
facility: El Paso Pulmonary Association
state: Texas
city: Houston
country: United States
facility: Baylor College of Medicine
state: Texas
city: McKinney
country: United States
facility: Research Centers of America
state: Texas
city: The Woodlands
country: United States
facility: Renovatio Clinical Research
state: Texas
city: Waxahachie
country: United States
facility: Topline Clinical Research
state: Texas
city: Salt Lake City
country: United States
facility: University of Utah
state: Utah
city: Burlington
country: United States
facility: University of Vermont Medical Center
state: Vermont
city: Falls Church
country: United States
facility: INOVA Fairfax Medical Campus
state: Virginia
city: Everett
country: United States
facility: Western Washington Medical Group
state: Washington
city: Mar del Plata
country: Argentina
facility: Centro de Investigaciones Medicas Mar del Plata
state: Buenos Aires
city: Mar Del Plata
country: Argentina
facility: Instituto Ave Pulmo
state: Buenos Aires
city: Munro
country: Argentina
facility: Clinica Privada Independencia
state: Buenos Aires
city: Quilmes
country: Argentina
facility: Centro Respiratorio Quilmes
state: Buenos Aires
city: Vicente López
country: Argentina
facility: CEMER - Centro Medico de Enfermedades Respiratorias
state: Buenos Aires
city: Ciudad Autonoma de Buenos Aires
country: Argentina
facility: Centro de Investigacion Clinica-CEDIC
state: Ciudad Autonoma Buenos Aires
city: Buenos Aires
country: Argentina
facility: Centro Médico Dra de Salvo
state: Ciudad Autónoma De BuenosAires
city: Rosario
country: Argentina
facility: Instituto Médico de la Fundación Estudios Clínicos
state: Santa Fe
city: Rosario
country: Argentina
facility: Sanatorio Parque de Rosario
state: Santa Fe
city: San Miguel De Tucumán
country: Argentina
facility: Centro Integral de Medicina Respiratoria (CIMER)
state: Tucumán
city: Ciudad Autónoma de Buenos Aires
country: Argentina
facility: Consultorios Médicos Organización de Buen Ayre SRL
city: Córdoba
country: Argentina
facility: Instituto de Medicina Respiratoria
city: Mendoza
country: Argentina
facility: Fundacion Scherbovsky
city: Mendoza
country: Argentina
facility: INSARES
city: Camperdown
country: Australia
facility: Royal Prince Alfred Hospital
state: New South Wales
city: Chermside
country: Australia
facility: Lung Research Qld
state: Queensland
city: Kent Town
country: Australia
facility: Respiratory Clinical Trials
state: South Australia
city: Woodville South
country: Australia
facility: The Queen Elizabeth Hospital
state: South Australia
city: Box Hill
country: Australia
facility: Box Hill Hospital
state: Victoria
city: Clayton
country: Australia
facility: Monash Medical Centre
state: Victoria
city: Heidelberg
country: Australia
facility: Austin Health
state: Victoria
city: Melbourne
country: Australia
facility: The Alfred Hospital
state: Victoria
city: Murdoch
country: Australia
facility: Fiona Stanley Hospital
state: Western Australia
city: Spearwood
country: Australia
facility: TrialsWest
state: Western Australia
city: Midland
country: Australia
facility: Institute for Respiratory Health - Midland
city: Roeselare
country: Belgium
facility: AZ Delta
state: West-Vlaanderen
city: Leuven
country: Belgium
facility: UZ Leuvan
city: Belo Horizonte
country: Brazil
facility: Santa Casa de Misericordia de Belo Horizonte
state: Minas Gerais
city: Porto Alegre
country: Brazil
facility: Irmandade da Santa Casa de Misericórdia de Porto Alegre
state: Rio Grande Do Sul
city: Porto Alegre
country: Brazil
facility: Hospital Ernesto Dornelles
state: Rio Grande Do Sul
city: Porto Alegre
country: Brazil
facility: Hospital Nossa Senhora da Conceicao
state: Rio Grande Do Sul
city: Porto Alegre
country: Brazil
facility: Hospital de Clinicas de Porto Alegre HCPA - PPDS
city: Porto Alegre
country: Brazil
facility: Hospital São Lucas da PUCRS
city: Kelowna
country: Canada
facility: Kelowna Respirology and Allergy Research
state: British Columbia
city: Vancouver
country: Canada
facility: Pacific Lung Research Center
state: British Columbia
city: Ajax
country: Canada
facility: Dynamic Drug Advancement
state: Ontario
city: Greenfield Park
country: Canada
facility: Centre intégré de santé et de services sociaux (CISSS) de la Montérégie-Centre
state: Quebec
city: Saint-Charles-Borromee
country: Canada
facility: CIC Joliette
state: Quebec
city: Trois-Rivieres
country: Canada
facility: Centre d'investigation Clinique Mauricie
state: Quebec
city: Quillota
country: Chile
facility: CENRESIN
city: Santiago
country: Chile
facility: Av. Providencia 1208 oficina 209
city: Santiago
country: Chile
facility: CEC SpA
city: Santiago
country: Chile
facility: Biocinetic
city: Talca
country: Chile
facility: Centro de Investigacion del Maule
city: Hefei
country: China
facility: The Second Hospital of Anhui Medical University
state: Anhui
city: Guangzhou
country: China
facility: The First Affiliated Hospital of Guangzhou Medical University
state: Guangdong
city: Guangzhou
country: China
facility: Nanfang Hospital of Southern Medical University
state: Guangdong
city: Shijiazhuang
country: China
facility: The 3rd Hospital of Hebei Medical University
state: Hebei
city: Yichang
country: China
facility: Yichang Central People's Hospital
state: Hubei
city: Changsha
country: China
facility: The second Xiangya Hospital of Central South University
state: Hunan
city: Xuzhou
country: China
facility: The Affiliated Hospital of Xuzhou Medical College
state: Jiangsu
city: Nanchang
country: China
facility: The First Affiliated Hospital of Nanchang University
state: Jiangxi
city: Jinan
country: China
facility: Qilu Hospital of Shandong University
state: Shandong
city: Chengdu
country: China
facility: West China Hospital, Sichuan University
state: Sichuan
city: Chengdu
country: China
facility: Sichuan Academy of Medical Sciences · Sichuan Provincial People's Hospital
state: Sichuan
city: Tianjin
country: China
facility: Tianjin Medical University General Hospital
state: Tianjin
city: Hangzhou
country: China
facility: Hangzhou First People's Hospital
state: Zhejiang
city: Brno
country: Czechia
facility: Fakultni nemocnice Brno
state: Jihomoravský Kraj
city: Olomouc
country: Czechia
facility: Fakultni Nemocnice Olomouc
state: Olomoucký Kraj
city: Praha 4
country: Czechia
facility: Fakultni Thomayerova Nemocnice
city: Odense
country: Denmark
facility: Odense Universitetshospital
state: South Denmark
city: Aarhus
country: Denmark
facility: Aarhus Universitetshospital
city: Aarhus
country: Denmark
facility: Aarhus Universitetshospital
city: Hellerup
country: Denmark
facility: Gentofte Hospital
city: Odense
country: Denmark
facility: Odense Universitetshospital
city: Rennes
country: France
facility: Hôpital Pontchaillou
state: Ille-et-Vilaine
city: Lille Cedex
country: France
facility: Institut Coeur Poumon - CHU de Lille
state: Nord
city: Bordeaux
country: France
facility: CHU de Bordeaux- Hopital du Haut Lévêque
city: Lyon
country: France
facility: CHU Lyon - Hôpital Cardio-Vasculaire et Pneumologique Louis Pradel
city: Marseille
country: France
facility: Hôpital Nord - CHU Marseille
city: Montpellier
country: France
facility: CHU Arnaud de Villeneuve
city: Nice
country: France
facility: CHU Nice - Hôpital Pasteur
city: Nice
country: France
facility: Hopital Pasteur CHU Nice
city: Paris
country: France
facility: Hospital Bretonneau
city: Paris
country: France
facility: Hôpital Bichat - Claude Bernard
city: Pessac
country: France
facility: Hopital Haut-Leveque Pharmacie
city: Reims
country: France
facility: CHU Reims - Hôpital Maison Blanche
city: Toulouse
country: France
facility: Hopital Larrey
city: München
country: Germany
facility: LMU Klinikum der Universität München - Campus Großhadern
state: Bayern
city: Gießen
country: Germany
facility: Universitätsklinikum Gießen (UKGM)
state: Hessen
city: Hannover
country: Germany
facility: Medizinische Hochschule Hannover
state: Niedersachsen
city: Essen
country: Germany
facility: Ruhrlandklinik
state: Nordrhein-Westfalen
city: Köln
country: Germany
facility: Kliniken der Stadt Koln
state: Nordrhein-Westfalen
city: Solingen
country: Germany
facility: Krankenhaus Bethanien
state: Nordrhein-Westfalen
city: Coswig
country: Germany
facility: Fachkrankenhaus Coswig
state: Sachsen
city: Kiel
country: Germany
facility: Universitätsklinikum Schleswig-Holstein, Campus Kiel
state: Schleswig-Holstein
city: Bad Berka
country: Germany
facility: Zentralklinik Bad Berka
state: Thüringen
city: Berlin
country: Germany
facility: Evangelische Lungenklinik Berlin
city: Coswig
country: Germany
facility: Fachkrankenhaus Coswig GmbH
city: Frankfurt
country: Germany
facility: IKF Pneumologie GmbH &amp; Co. KG
city: Homburg
country: Germany
facility: Universitaetsklinikum des Saarlandes
city: Leipzig
country: Germany
facility: Universitaetsklinikum Leipzig AoeR
city: Patras
country: Greece
facility: University General Hospital of Patras
state: Achaïa
city: Athens
country: Greece
facility: Sotiria Thoracic Diseases Hospital of Athens
state: Attiki
city: Alexandroupoli
country: Greece
facility: University General Hospital of Alexandroupolis
state: Evros
city: Ioánnina
country: Greece
facility: University General Hospital of Ioannina
state: Ioannina
city: Heraklion
country: Greece
facility: University General Hospital of Heraklion
city: Larissa
country: Greece
facility: University General Hospital of Larissa
city: Faridabad
country: India
facility: ESIC Medical College and Hospital
state: Haryana
city: Belgaum
country: India
facility: K.L.E. Society's Dr. Prabhakar Kore Hospital and Medical Research Centre
state: Karnataka
city: Belgaum
country: India
facility: BHS Lakeview Hospital
state: Karnataka
city: Mumbai
country: India
facility: Bhatia Hospital
state: Maharashtra
city: Nashik
country: India
facility: Siddhi Hospital
state: Maharashtra
city: Ajmer
country: India
facility: J.L.N., Medical College and Attached Hospitals
state: Rajasthan
city: Lucknow
country: India
facility: Midland Healthcare & Research Center
state: Uttar Pradesh
city: Kolkata
country: India
facility: Calcutta Medical Research Institute
state: West Bengal
city: Kolkata
country: India
facility: B. P. Poddar Hospital and Medical Research Limited
state: West Bengal
city: Ashkelon
country: Israel
facility: Barzilai Medical Center
state: HaDarom
city: Reẖovot
country: Israel
facility: Kaplan Medical Center
state: HaMerkaz
city: Ashkelon
country: Israel
facility: Tel Aviv Sourasky Medical Center
state: Tel-Aviv
city: Ramat Gan
country: Israel
facility: Sheba Medical Center
state: Tel-Aviv
city: Jerusalem
country: Israel
facility: Shaare Zedek Medical Center
state: Yerushalayim
city: Beer-Sheva
country: Israel
facility: Soroka University Medical Center
city: Haifa
country: Israel
facility: Lady Davis Carmel Medical Center
city: Haifa
country: Israel
facility: Rambam Medical Center
city: Kfar-Saba
country: Israel
facility: Meir Medical Center
city: Petach Tikva
country: Israel
facility: Rabin Medical Center
city: Milan
country: Italy
facility: Ospedale San Giuseppe Multimedica SpA
state: Milano
city: Alessandria
country: Italy
facility: Azienda Ospedaliera Nazionale SS. Antonio e Biagio e Cesare Arrigo
city: Bergamo
country: Italy
facility: ASST Papa Giovanni XXIII - Azienda Ospedaliera Papa Giovanni XXIII
city: Firenze
country: Italy
facility: Azienda Ospedaliera Universitaria Careggi
city: Foggia
country: Italy
facility: Azienda Ospedaliero-Universitaria Ospedali Riuniti di Foggia
city: Roma
country: Italy
facility: Policlinico Universitario Fondazione Agostino Gemelli - Roma
city: Fukuoka-shi
country: Japan
facility: NHO Kyushu Medical Center
state: Fukuoka-Ken
city: Fukuoka-shi
country: Japan
facility: Fukuoka University Hospital
state: Fukuoka-Ken
city: Iizuka-shi
country: Japan
facility: Aso Co.,Ltd Iizuka Hospital
state: Fukuoka-Ken
city: Kitakyushu-shi
country: Japan
facility: Hospital of the University of Occupational and Environmental Health
state: Fukuoka-Ken
city: Fukushima-shi
country: Japan
facility: Fukushima Medical University Hospital
state: Fukushima-Ken
city: Hiroshima-shi
country: Japan
facility: Hiroshima Prefectural Hospital
state: Hiroshima-Ken
city: Sapporo-shi
country: Japan
facility: Sapporo Medical University Hospital
state: Hokkaido
city: Kobe-shi
country: Japan
facility: Kobe City Hospital Organization
state: Hyogo-Ken
city: Kobe-shi
country: Japan
facility: Center General Hospital
state: Hyogo-Ken
city: Naka-gun
country: Japan
facility: NHO Ibarakihigashi National Hospital
state: Ibaraki-Ken
city: Yokohama-shi
country: Japan
facility: Kanagawa Cardiovascular and Respiratory Center
state: Kanagawa-Ken
city: Kumamoto-shi
country: Japan
facility: Kumamoto University Hospital
state: Kumamoto-Ken
city: Okayama-shi
country: Japan
facility: Okayama University Hospital
state: Okayama-Ken
city: Osaka-shi
country: Japan
facility: NHO Kinki-Chuo Chest Medical Center
state: Osaka-Fu
city: Kumagaya-shi
country: Japan
facility: Saitama Prefectural Cardiovascular and Respiratory Center
state: Saitama-Ken
city: Saitama-shi
country: Japan
facility: Saitama Red Cross Hospital
state: Saitama-Ken
city: Izumo-shi
country: Japan
facility: Shimane University Hospital
state: Shimane-Ken
city: Hamamatsu-shi
country: Japan
facility: Hamamatsu University School of Medicine, University Hospital
state: Shizuoka-Ken
city: Bunkyo-ku
country: Japan
facility: Institute of Science Tokyo Hospital
state: Tokyo-To
city: Bunkyo-ku
country: Japan
facility: Nippon Medical School Hospital
state: Tokyo-To
city: Minato-Ku
country: Japan
facility: Juntendo University Hospital
state: Tokyo-To
city: Busan
country: Korea, Republic of
facility: Inje University Busan Paik Hospital
state: Gyeongsangnamdo
city: Seoul
country: Korea, Republic of
facility: Korea University Anam Hospital
state: Seoul Teugbyeolsi
city: Seoul
country: Korea, Republic of
facility: Hanyang University Medical Center
state: Seoul Teugbyeolsi
city: Busan
country: Korea, Republic of
facility: Inje University Haeundae Paik Hospital
city: Seoul
country: Korea, Republic of
facility: Severance Hospital, Yonsei University Health System
city: Seoul
country: Korea, Republic of
facility: The Catholic University of Korea, Seoul St. Mary's Hospital
city: Amsterdam
country: Netherlands
facility: VU Medisch Centrum
state: Noord-Holland
city: Nieuwegein
country: Netherlands
facility: St. Antonius Ziekenhuis
state: Utrecht
city: Christchurch
country: New Zealand
facility: Christchurch Hospital
state: Canterbury
city: Auckland
country: New Zealand
facility: Greenlane Clinical Centre
state: North Island
city: Dunedin
country: New Zealand
facility: Dunedin Hospital
state: Otago
city: Hamilton
country: New Zealand
facility: Waikato Hospital
state: Waikato
city: Nowa Sól
country: Poland
facility: Twoja Przychodnia NCM
state: Lubuskie
city: Bydgoszcz
country: Poland
facility: Vitamed Galaj i Cichomski sp.j.
city: Gdańsk
country: Poland
facility: Uniwersyteckie Centrum Kliniczne
city: Kraków
country: Poland
facility: SP ZOZ Szpital Uniwersytecki w Krakowie
city: Łódź
country: Poland
facility: IP Clinic Sp. z o. o.
city: Braga
country: Portugal
facility: Hospital de Braga
city: Lisbon
country: Portugal
facility: Centro Hospitalar de Lisboa Central, E.P.E - Hospital de Santa Marta
city: Vila Nova de Gaia
country: Portugal
facility: Centro Hospitalar Vila Nova de Gaia/Espinho, E.P.E.
city: Majadahonda
country: Spain
facility: Hospital Universitario Puerta de Hierro - Majadahonda
state: Madrid
city: Barcelona
country: Spain
facility: Hospital Universitari de Bellvitge
city: Majadahonda
country: Spain
facility: Hospital Universitario Puerta de Hierro Majadahonda
city: Málaga
country: Spain
facility: Hospital Clinico Universitario Virgen de la Victoria
city: Santiago De Compostela
country: Spain
facility: CHUS - H. Clinico U. de Santiago
city: Kaohsiung City
country: Taiwan
facility: Kaohsiung Medical University - Chung-Ho Memorial Hospital
city: Taichung
country: Taiwan
facility: China Medical University Hospital
city: Taichung
country: Taiwan
facility: Taichung Veterans General Hospital
city: Taipei
country: Taiwan
facility: National Taiwan University Hospital
city: Taipei
country: Taiwan
facility: Taipei Veterans General Hospital
city: Taipei
country: Taiwan
facility: Far Eastern Memorial Hospital
city: Londonderry
country: United Kingdom
facility: Altnagelvin Area Hospital
state: Derry
city: Southampton
country: United Kingdom
facility: Southampton General Hospital
state: Hampshire
city: Edinburgh
country: United Kingdom
facility: Western General Hospital
state: Lothian Region
city: Cottingham
country: United Kingdom
facility: Castle Hill Hospital
state: North Humberside
city: Wakefield
country: United Kingdom
facility: Pinderfields General Hospital
state: West Yorkshire
city: Birmingham
country: United Kingdom
facility: Birmingham Heartlands Hospital
city: London
country: United Kingdom
facility: Royal Brompton Hospital
Study officials:
affiliation: Pliant Therapeutics, Inc.
name: Pliant Therapeutics Medical Monitor
role: STUDY_DIRECTOR
References: