Clinical trial NCT03334019: Prevalence and Risk Factors for Coxiella Burnetii Seropositivity (Q Fever) Among Adults in Western France
Official title: Prevalence and Risk Factors for Coxiella Burnetii Seropositivity (Q Fever) Among Adults in Western France
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Q Fever
Lead sponsor: Nantes University Hospital
Sponsor class: OTHER
Collaborators: name: ONIRIS
First posted: 2017-11-07
Enrollment: 559
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: * blood donors at blood donation organizations (general population)
* beef and dairy cattle farmers
* veterinarians involved in a rural practice

Brief summary: Diseases naturally transmitted between animals and humans (zoonoses) are one of the leading causes of emergence or re-emergence of human infectious diseases. Non-foodborne zoonoses are commonly transmitted to human directly by contact with infected animals or contaminated environment. People working with animals such as farmers and veterinarians are particularly at risk of infection. Some zoonoses can also be transmitted indirectly thought the air and therefore can affect the general population. Example is Q fever, a disease caused by Coxiella burnetii, a bacterium highly resistant in the environment.

In Western France, Q fever is endemic in cattle herds. To improve human zoonotic disease surveillance, the investigators will conduct a population based study in this area.

The aims of the study are:

1. To assess seroprevalence of Coxiella burnetii infection among general population, farmers and veterinarians in Western France
2. To identify risk factors for Coxiella burnetii seropositivity in these populations

Detailed description: In order to estimate seroprevalence and risk factors for Coxiella burnetii infection in humans, the investigators will conduct a cross-sectional study in three groups:

* blood donors at blood donation organizations (general population)
* beef and dairy cattle farmers
* veterinarians involved in a rural practice

All the participants in the study will provide a blood sample and will fill in a questionnaire.

Eligibility criteria: Inclusion Criteria:

* Give a written informed consent
* Be 18 years old and over
* Be able to speak French

Exclusion Criteria:

* Adults under protection (guardianship or curators)
* Contraindication for drawing blood

Primary outcomes:
measure: Antibody titers against Coxiella burnetii in general population in Western France
timeFrame: Day 0
measure: Antibody titers against Coxiella burnetii in farmers population in Western France
timeFrame: Day 0
measure: Antibody titers against Coxiella burnetii in veterinarians population in Western France
timeFrame: Day 0
Secondary outcomes:
measure: Measure of association between Coxiella burnetii seropositivity risk and socio-demographic
timeFrame: Day 0
measure: Measure of association between Coxiella burnetii seropositivity risk and lifestyle
timeFrame: Day 0
measure: Measure of association between Coxiella burnetii seropositivity risk and occupational factors.
timeFrame: Day 0
measure: Measure of association between Coxiella burnetii seropositivity in humans (general population) and cattle herds' prevalence of Coxiella burnetii infection.
timeFrame: Day 0
measure: Measure of association between Coxiella burnetii seropositivity in humans (farmers) and cattle herds' prevalence of Coxiella burnetii infection.
timeFrame: Day 0
measure: Measure of association between Coxiella burnetii seropositivity in humans ( veterinarians) and cattle herds' prevalence of Coxiella burnetii infection.
timeFrame: Day 0
Other outcomes:
Locations:
city: Nantes
country: France
facility: CHU de Nantes
city: Nantes
country: France
facility: CHU de Nantes
Study officials:
affiliation: Nantes University Hospital
name: Leila Moret, PU-PH
role: PRINCIPAL_INVESTIGATOR
References: