Clinical trial NCT03917186: Desflurane vs. Sevoflurane in Endovascular Aortic Repair
Official title: Fast-track in Endovascular Aortic Aneurysm Repair With Desflurane and Sevoflurane: a Randomized Clinical Trial
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE4
Conditions: Renal Failure
Keywords: Desflurane, Sevoflurane, Endovascular aortic repair
Lead sponsor: Hospital General Universitario Gregorio Marañon
Sponsor class: OTHER
Collaborators: name: Baxter Healthcare Corporation
First posted: 2019-04-16
Enrollment: 80
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: OTHER

Brief summary: Randomized Clinical Trial following the evaluation of the impact on renal function in patients undergoing endovascular aortic aneurysm repair with two anesthetics protocols (Desflurane versus Sevoflurane) on the first 24 hours after surgery.

Detailed description: Randomized Clinical Trial to evaluate the impact on renal function in patients undergoing endovascular aortic aneurysm repair with two anesthetics protocols (Desflurane versus Sevoflurane) on the first 24 hours after surgery.

Secondary Endpoint: Among secondary endpoints we will evaluate clinical variables such emergence and recovery characteristics (time to extubation and time to emergence-open eyes and response to verbal command), the need for postoperative mechanical ventilation, the post-anesthesia recovery score and ICU length of stay.

Eligibility criteria: Inclusion Criteria:

* older than 18 years undergoing elective endovascular aortic repair
* who have signed informed consent

Exclusion Criteria:

* urgent surgery
* with known hypersensitivity to Desflurane or Sevoflurane.
* Renal failure in hemodialysis

Primary outcomes:
measure: Change in Biochemical parameters
timeFrame: All these parameters will be evaluated at baseline (presurgery), at the end surgery and 24 hours after surgery in both study groups
measure: Change in Biochemical parameters
timeFrame: will be evaluated at baseline (presurgery), at the end surgery and 24 hours after surgery in both study groups
measure: Change in Biochemical parameters
timeFrame: will be evaluated at baseline (presurgery), at the end surgery and 24 hours after surgery in both study groups
measure: Change in Biochemical parameters
timeFrame: will be evaluated at baseline (presurgery), at the end surgery and 24 hours after surgery in both study groups
measure: Change in Biochemical parameters
timeFrame: will be evaluated at baseline (presurgery), at the end surgery and 24 hours after surgery in both study groups
measure: Change in Biochemical parameters
timeFrame: will be evaluated at baseline (presurgery), at the end surgery and 24 hours after surgery in both study groups
measure: Change in Biochemical parameters
timeFrame: will be evaluated at baseline (presurgery), at the end surgery and 24 hours after surgery in both study groups
measure: Change in Biochemical parameters
timeFrame: will be evaluated at baseline (presurgery), at the end surgery and 24 hours after surgery in both study groups
measure: Change in Biochemical parameters
timeFrame: will be evaluated at baseline (presurgery), at the end surgery and 24 hours after surgery in both study groups
measure: Change in Biochemical parameters
timeFrame: will be evaluated at baseline (presurgery), at the end surgery and 24 hours after surgery in both study groups
measure: Change in Biochemical parameters
timeFrame: will be evaluated at baseline (presurgery), at the end surgery and 24 hours after surgery in both study groups
measure: Change in Biochemical parameters
timeFrame: will be evaluated at baseline (presurgery), at the end surgery and 24 hours after surgery in both study groups
measure: Change in Biochemical parameters
timeFrame: will be evaluated at baseline (presurgery), at the end surgery and 24 hours after surgery in both study groups
measure: Change in Biochemical parameters
timeFrame: will be evaluated at baseline (presurgery), at the end surgery and 24 hours after surgery in both study groups
measure: Change in Biochemical parameters
timeFrame: will be evaluated at baseline (presurgery), at the end surgery and 24 hours after surgery in both study groups
Secondary outcomes:
measure: Need for postoperative mechanical ventilation
timeFrame: 24 hours
measure: ICU length of stay
timeFrame: up to 24 hours
measure: anesthetic recovery
timeFrame: These variable will be recorded immediately after surgery (from anesthetics discontinuation). The postanesthesia recovery score before will be recorded at baseline and after surgery. time frame upto 1 hour(stimated)
measure: anesthetic recovery
timeFrame: These variable will be recorded immediately after surgery (from anesthetics discontinuation). The postanesthesia recovery score before will be recorded after surgery. timeframe up to 1 hour(stimated).
measure: anesthetic recovery
timeFrame: These variable will be recorded immediately after surgery (from anesthetics discontinuation). The postanesthesia recovery score before will be recorded after surgery. timeframe up to 1 hour(stimated).
measure: anesthetic recovery
timeFrame: These variable will be recorded immediately after surgery (from anesthetics discontinuation). The postanesthesia recovery score before will be recorded at baseline and after surgery. timeframe 1 hour(stimated)
Other outcomes:
Locations:
city: Madrid
country: Spain
facility: Hospital general universitario Gregorio Marañón
Study officials:
affiliation: Hospital General Universitario Gregorio Marañón
name: Begoña Quintana, PhD
role: PRINCIPAL_INVESTIGATOR
References: