Clinical trial NCT04779463: Role of Ultrasound Assessment of Parasternal Intercostal Muscle Thickness During Weaning From Mechanical Ventilation
Official title: Role of Ultrasound Assessment of Parasternal Intercostal Muscle Thickness During Weaning From Mechanical Ventilation
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Parasternal Intercostal Muscle Thickness
Weaning From Mechanical Ventilation
Keywords: mechanical ventilation, parasternal muscle thickness
Lead sponsor: Menoufia University
Sponsor class: OTHER
First posted: 2021-03-03
Enrollment: 40
Sex: ALL
Minimum age (years): 18
Maximum age (years): 80
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: All patients are invasively mechanically ventilated at least 24 hours, and are clinically stable as ready to undergo a spontaneous breathing trial (SBT).

Brief summary: Assessment of the the parasternal intercostal muscles thickness by the ultrasonography as a weaning predictor of the mechanically ventilated patients

Detailed description: impact of parasternal muscle thickness on the weaning process of the mechanically ventilated patients in ICU

Eligibility criteria: Inclusion Criteria:

Any patient invasively mechanically ventilated at least 24 hours on a pressure support mode who is clinically stable and ready to undergo a spontaneous breathing trial.

All patients will be:

* Alert.
* Afebrile.
* Adequate cough with absence of excessive tracheobronchial secretion.
* Fraction of inspired oxygen (FIO2) of \<50%.
* PEEP ≤8 cmH2O.
* PaO2/FiO2 \> 150.
* pH ≥7.35 and ≤7.45.
* Respiratory rate (RR) ≤35 breaths/min.
* Hemodynamically stable in the absence of vasopressors.
* Stable metabolic and endocrinal status.
* Euglycemic state.
* Adequate mentation (no sedation or stable neurologic patient).

Exclusion Criteria:

Diaphragmatic paralysis (detected by ultrasonography).Patients\&Methods. 6

* Pregnant women.
* Age: \>= 18 years.
* Surgical dressings over measurement point which would preclude ultrasound exam.
* Underweight patients (Body mass index \<18.5 kg/m2).
* Morbidly obese patient (Body mass index ≥ 40 kg/m2).
* Primary neuro-muscular diseases.
* Central coditions with depressed central respiratory drive (encephalitis, and brainstem haemorrhage/ischaemia).
* Repiratory conditions with reduced pulmonary compliance (interstitial lung disease, pulmonary hemorrhage, and diffuse pulmonary infiltrates) or reduced chest wall compliance (kyphoscoliosis).
* Cardiac conditions with high risk of weaning induced pulmonary edema (congestive heart failure, cyanotic heart diease, pulmonary hypertension, and ischemic heart diease).
* Addict patients.
* Patients with psychiatric disease.

Primary outcomes:
measure: the thickness fraction of the parasternal intercostal muscle as a predictor of successful spontaneous breathing trials
timeFrame: Before the start spontaneous breathing trial
Secondary outcomes:
Other outcomes:
Locations:
city: Shibīn Al Kawm
country: Egypt
facility: Faculty of Medicine - Menoufia University
state: Menoufia
Study officials:
affiliation: faculty of medicine, Menoufia University
name: Wesameldin A Soltan, M.D.
role: STUDY_DIRECTOR
References: