Clinical trial NCT04114565: Prevalence of Major Depression Among Immigrants in Santiago, Chile
Official title: The Santiago Immigrant Wellbeing Study (STRING): Prevalence of Mood Disorders Among Immigrants in Santiago, Chile
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Major Depressive Disorder
Keywords: prevalence
mood disorders
affective disorders
major depressive disorder
service use
migration health
global mental health
Lead sponsor: Pontificia Universidad Catolica de Chile
Sponsor class: OTHER
Collaborators: name: Fondo Nacional de Desarrollo Científico y Tecnológico, Chile
First posted: 2019-10-03
Enrollment: 1092
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: ECOLOGIC_OR_COMMUNITY
Time perspective: CROSS_SECTIONAL
Sampling method: PROBABILITY_SAMPLE
Study population: Adults residing in private households in the Metropolitan Region of Santiago, Chile who were born outside of Chile and have lived in the country for at least 3 months

Brief summary: The general aim of this study is to explore the prevalence of major depressive disorder and the use of mental health services in the immigrant populations in the Metropolitan Region of Santiago, Chile.

The hypotheses are:

1. A healthy immigrant effect will be observed in the studied population by which their prevalence of major depressive disorder will be lower than the prevalence in the general Chilean population.
2. A significant association will be observed between the loss of socio-economic position after migration and a greater probability of major depressive disorder.
3. A significant association will be observed between the report of victimization experience(s) in the previous year and a greater probability of major depressive disorder.
4. A significant association will be observed between financial difficulties and a greater probability of major depressive disorder.

The sampling framework of the Chilean National Institute of Statistics (INE) from the 2016 Census will be used for the purpose of this research. The sampling units are as follows:

1. Primary sampling units (PSUs): conglomerates or groups of adjoining houses, organized in spatial blocks (200 households on average)
2. Secondary sampling units (SSUs): individual households within each of the conglomerates selected in the first stage
3. Final sampling units: persons meeting the study's inclusion criteria Multi-stage random probability sampling involving a 3-stage sampling design will be used - first, the sampling of the primary sampling units (PSUs); second, the sampling of households within the selected PSUs and finally, the random sampling of a household member.

Participants (n=1,100) will then take part in a 45-minute interview. This interview will be a household survey using the modular version of the Composite International Diagnostic Interview (WHO-CIDI) looking at exploring a broad spectrum of factors traditionally associated with increased risk of affective disorders:

1. Sociodemographics
2. Finance
3. Variation in socioeconomic position
4. Experience of victimization
5. Discrimination
6. Experience of childhood adversity


Eligibility criteria: Inclusion Criteria:

* Country of birth other than Chile
* Time since arrival to Chile: 3 months

Exclusion Criteria:

* Unable to understand Spanish

Primary outcomes:
measure: Major Depressive Disorder
timeFrame: baseline
measure: Any affective/mood disorder
timeFrame: baseline
measure: Suicidal ideation, plans and attempts
timeFrame: baseline
measure: Depressive symptoms
timeFrame: baseline
measure: Anxiety symptoms
timeFrame: baseline
Secondary outcomes:
measure: Mental wellbeing
timeFrame: baseline
measure: Mental health service use
timeFrame: baseline
measure: Hazardous/harmful drinking
timeFrame: baseline
Other outcomes:
Locations:
city: Santiago
country: Chile
facility: Pontificia Universidad Catolica de Chile
state: RM
Study officials:
affiliation: Universidad Catolica de Chile
name: Antonia Errazuriz, PhD
role: PRINCIPAL_INVESTIGATOR
References: