Clinical trial NCT03643315: Determinants of Post-Exercise Eating Patterns
Official title: Determinants of Post-Exercise Eating Patterns / Alternative Title (Cover): Effect of Pre-meal Activities on Blood Pressure in Healthy Adults
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Obesity
Keywords: Appetite regulation
Eating behaviour
Exercise
HIIT
Lead sponsor: Singapore Institute of Food and Biotechnology Innovation
Sponsor class: OTHER_GOV
Collaborators: name: Nanyang Technological University
First posted: 2018-08-22
Enrollment: 30
Sex: MALE
Minimum age (years): 21
Maximum age (years): 40
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: CROSSOVER
Intervention model description: The present study will be of a randomised counterbalanced repeated-measures (crossover) design. Each participant (n = 30) will complete four sessions; one initial screening session (remotely administered), one baseline/familiarisation session (first lab visit) and two subsequent experimental sessions (second and third lab visits). The two experimental sessions will follow a similar protocol, except that one condition will involve an exercise protocol before an ad-libitum meal (Exercise and Meal (EX) condition), and the other, a no-exercise period (rest) before an ad-libitum (NEX) control condition.
Primary purpose: OTHER

Brief summary: This study examines potential physiological and psychological determinants of food intake in response to exercise. Specifically, beyond measuring actual food consumption and physiological markers typically assessed during exercise and appetite work (i.e. appetite hormones, blood glucose), the investigators wish to investigate the influence of individual behavioural differences (attitudes towards eating, licensing/compensatory health beliefs, self-regulation, and exercise-associated motivation) on the relationship between exercise and eating behaviour.


Eligibility criteria: Inclusion Criteria:

* Male
* Inactive (\< 90 min of moderate-intensity exercise a week)
* BMI: 23 and above
* Age between 21 to 40 years
* Normal fasting blood glucose levels equal to or less than 5.9 mmol/L
* Non-smoker
* No know allergies or intolerance to food
* Not on any prescribed medication
* No physical disabilities and/or restrictions; not averse to exercising on a stationary bike or treadmill running
* No aversion to blood sampling procedures (e.g. finger prick, cannulation)

Exclusion Criteria:

* Female,
* Smoker,
* Fasting blood glucose \> 5.9 mmol/L,
* Resting blood pressure \> 140/90 mmHg,
* Any major medical/health conditions including

  * Diabetes,
  * Metabolic disease
  * Hypertension,
  * Cardiovascular disease,
  * Thyroid disorders,
  * G6PD deficiency.
* Allergic or intolerant to foods presented in the study.
* Physical disabilities and/or restrictions.
* Individuals that are adverse to exercising on a stationary exercise bike or treadmill.
* Adverse to blood sampling procedures (i.e. cannulation, finger pricks, venepuncture).

Primary outcomes:
measure: Ad-libitum amount of food consumed in response to experimental condition: exercise or rest (no exercise).
timeFrame: 3 hours
Secondary outcomes:
measure: Appetite-related blood hormone concentration in response to experimental conditions.
timeFrame: 3 hours
measure: Metabolic blood variable concentration in response to experimental conditions
timeFrame: 3 hours
measure: Subjective ratings of hunger in response to experimental conditions
timeFrame: 3 hours
measure: Subjective ratings of satiation (fullness) in response to experimental conditions
timeFrame: 3 hours
measure: Subjective ratings of desire to eat in response to experimental conditions
timeFrame: 3 hours
measure: Subjective ratings of prospective food consumption in response to experimental conditions
timeFrame: 3 hours
measure: Free-living energy intake (1 day post-experiment) in response to experimental conditions
timeFrame: 1 day
measure: Free-living physical activity levels intake (1 day post-experiment) in response to experimental conditions
timeFrame: 1 day
Other outcomes:
measure: Self-reported tendencies of compensatory health beliefs
timeFrame: Assessed at start of study - through study completion - up to 4-5 weeks
measure: Self-reported tendencies of licensing/reward beliefs
timeFrame: Assessed at start of study - through study completion - up to 4-5 weeks
measure: Self-reported tendencies and motives of compensatory eating behaviour in response to exercise
timeFrame: Assessed at start of study - through study completion - up to 4-5 weeks
measure: Self-reported assessment of motivation (regulation) to exercise
timeFrame: Assessed at start of study - through study completion - up to 4-5 weeks
measure: Self-reported assessment of motivation to eat healthily
timeFrame: Assessed at start of study - through study completion - up to 4-5 weeks
measure: Self-reported attitudes towards eating behaviour as assessed by the Three Factor Eating Behaviour Questionnaire (TFEQ-R18)
timeFrame: Assessed at start of study - through study completion - up to 4-5 weeks
measure: Self-reported weight-related behaviour change status as assessed by the Physical Activity Stages of Change Questionnaire
timeFrame: Assessed at start of study - through study completion - up to 4-5 weeks
Locations:
city: Singapore
country: Singapore
facility: Clinical Nutrition Research Centre
Study officials:
References: