Clinical trial NCT06296875: The Krill Ageing Muscle Mechanisms (KAMM) Study
Official title: Uncovering the Mechanisms Through Which Krill Oil Increases Muscle Function in Older Adults.
Study type: INTERVENTIONAL
Overall status: RECRUITING
Phase: NA
Conditions: Sarcopenia
Keywords: Krill oil
Muscle Strength
Neuromuscular function
Physical function
Lead sponsor: University of Glasgow
Sponsor class: OTHER
First posted: 2024-03-06
Enrollment: 80
Sex: ALL
Minimum age (years): 65
Maximum age (years): 90
Standard ages: OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Intervention model description: 1:1 parallel group design
Primary purpose: PREVENTION

Brief summary: This study aims to determine the mechanisms via which krill oil supplementation increases muscle strength and whether this translates to improvements in gait and functional characteristics in older adults. The studies we will carry out will establish, in healthy older adults, the effects of 6 months of supplementation with krill oil

Objective 1) Muscle structure and function Hypothesis: Krill oil supplementation will increase muscle size and strength alongside positive changes in muscle architecture (pennation angle and fascicle length).

Objective 2) Neuromuscular control and central nervous system (CNS) function Hypothesis: Krill oil supplementation will improve Neuromuscular Junction (NMJ) transmission stability and increase central drive and intramuscular coherence, as a measure of muscle synergy.

Objective 3) Gait and functional characteristics Hypothesis: Krill oil supplementation will improve gait and functional characteristics.


Eligibility criteria: Inclusion Criteria:

* body mass index (BMI) \</= 30 kg/m2
* Age \>/= 65 years
* Capacity to consent
* Living within the Glasgow area

Exclusion Criteria:

* Diabetes mellitus
* Severe cardiovascular disease
* Seizure disorders
* Uncontrolled hypertension (\>150/90mmHg)
* Active cancer or cancer that has been in remission \<5 years
* Participation in any resistance exercise training within the last 6 months
* Impairments which may limit ability to perform assessments of muscle function
* Dementia
* Fish/shellfish allergy
* Taking medication known to affect muscle (e.g. steroids, Selective serotonin reuptake inhibitors) or anticoagulants (e.g. warfarin)
* Taking omega-3 supplements in the last 3 months
* Regularly consuming 1 or more portions of oily fish per week
* Not able to understand English

Primary outcomes:
measure: Grip strength
timeFrame: Change from baseline to 24 weeks
measure: Neuromuscular junction transmission instability
timeFrame: Change from baseline to 24 weeks
measure: Gait speed
timeFrame: Change from baseline to 24 weeks
Secondary outcomes:
measure: Knee extensor maximal torque
timeFrame: Change from baseline to 24 weeks
measure: Vastus lateralis muscle cross sectional area
timeFrame: Change from baseline to 24 weeks
measure: Vastus lateralis pennation angle
timeFrame: Change from baseline to 24 weeks
measure: Vastus lateralis fascicle length
timeFrame: Change from baseline to 24 weeks
measure: Erythrocyte fatty acid composition
timeFrame: Change from baseline to 24 weeks
measure: Knee extensor force steadiness
timeFrame: Change from baseline to 24 weeks
measure: Vastus lateralis motor unit conduction velocity
timeFrame: Change from baseline to 24 weeks
measure: Vastus lateralis and vastus medialis intramuscular coherence
timeFrame: Change from baseline to 24 weeks
measure: Hand flexor muscles intermuscular coherence
timeFrame: Change from baseline to 24 weeks
measure: Cortico-muscular coherence between sensory motor cortex and hand extensor muscles
timeFrame: Change from baseline to 24 weeks
measure: Femoral Nerve Stimulation
timeFrame: Change from baseline to 24 weeks
measure: Transcranial Magnetic Stimulation (TMS)
timeFrame: Change from baseline to 24 weeks
measure: TMS Inhibition
timeFrame: Change from baseline to 24 weeks
measure: TMS Excitation
timeFrame: Change from baseline to 24 weeks
measure: Gait characteristics during 4m walk test and the timed up and go test
timeFrame: Change from baseline to 24 weeks
measure: Gait cycle with leg support parameters
timeFrame: Change from baseline to 24 weeks
Other outcomes:
Locations:
city: Glasgow
country: United Kingdom
facility: University of Glasgow
Study officials:
References: