Clinical trial NCT03839186: Pharmacogenetics Study on the Effects of Anesthetic Drugs on Circulatory Function
Official title: The Effects of Anesthetic Drugs on Hemodynamic Changes in Cardiac Surgury and the Assotiation Between Gene Polymorphysim and Different Heart Diseases :a Pharmacogenetics Study
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Drug Reaction
Anesthetic
Hemodynamic Rebound
Gene
Keywords: personalized medicine
genetic polymorphism
pharmacogenetics
hemodynamic change
Lead sponsor: Xiangya Hospital of Central South University
Sponsor class: OTHER
First posted: 2019-02-15
Enrollment: 223
Sex: ALL
Minimum age (years): 20
Maximum age (years): 75
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: CASE_ONLY
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: Patients from department of thoracic and cardiovascular surgery in Xiangya Hospital, Central South University

Brief summary: This study intends to study the effects of anesthetics on Circulatory Function Genomics and find the anesthetic effects in pharmacodynamics, pharmacokinetics, drug receptor or target DNA level differences, further guiding individual treatment in clinic, promoting the development of precision the medicine.The anesthesia medication during perioperative period is more and more accurate,reasonable and safe, so as to improve the satisfaction of the patients and their families in the perioperative period, to ensure the safety of patients.

Detailed description: This study is a non traumatic and non intervention study, and will use a large sample of clinical research, the number of subjects to be enrolled in the study group are 200 cases. The basic information of the study was included in the study before the operation. During the operation, the investigators need a collection of participants's arterial blood and monitor the hemodynamic index and anesthesia depth by bispectral index(BIS) . Further more，the investigators will follow up the participants' condition after operation.Dividing the patients into different groups according to their clinical features.The relationship between vital signs and the depth of anesthesia was analyzed and compared between different groups.Blood samples collected during the operation were detected by gene test. Comparing the results of genetic testing and clinical data analysis, then the investigators will find the differences in the expression of the gene polymorphisms of anesthetic drugs in the circulating function.

Eligibility criteria: Inclusion Criteria:

* Undergoing general anesthesia
* Undergoing Cardiovascular surgery

Exclusion Criteria:

* ASA granding more than five
* Severe organ dysfunction

Primary outcomes:
measure: Genotyping results of anesthetic drugs
timeFrame: one year
Secondary outcomes:
measure: vital signs
timeFrame: one year
Other outcomes:
measure: depth of anesthesia
timeFrame: one year
measure: prognostic indicator
timeFrame: one year
Locations:
city: Changsha
country: China
facility: Xiangya Hospital of Central South University
state: Hunan
Study officials:
affiliation: Xiangya Hospital of Central South University
name: e wang, doctor
role: STUDY_CHAIR
References: