Clinical trial NCT04499196: Glucocorticoids and Pulmonary Hypertension
Official title: Prospective Study of Glucocorticoids as a Mechanism to Treat Pulmonary Hypertension
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Pulmonary Hypertension Due to Lung Diseases and Hypoxia
Pulmonary Hypertension
Bronchopulmonary Dysplasia
Lead sponsor: Washington University School of Medicine
Sponsor class: OTHER
First posted: 2020-08-05
Enrollment: 40
Sex: ALL
Minimum age (years): 1
Maximum age (years): 5
Standard ages: CHILD
Accepts healthy volunteers: no
Observational model: CASE_ONLY
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: neonates with BPD

Brief summary: Pediatric idiopathic pulmonary hypertension has significant morbidity and mortality. An ever expanding body of knowledge indicates the important contribution of inflammation to pathogenesis and successful treatment with glucocorticoids. Over the last several years the investigators have utilized steroids in patients with severe pulmonary hypertension as part of a treatment regimen. These basic science studies possibly identifies a biochemical etiology for the development of disease and may also be impacted by the administration of steroids. Additionally, there is a commercially available assay which tests for all of the above molecules.


Eligibility criteria: Inclusion Criteria:

* premature, BPD, \>36 wga
* pulmonary hypertension evidence by echocardiogram

Exclusion Criteria:

* poor ventilation/oxygenation

Primary outcomes:
measure: Echo estimation of RV pressure
timeFrame: 5 days
Secondary outcomes:
Other outcomes:
Locations:
city: Saint Louis
country: United States
facility: St. Louis Children's Hospital
state: Missouri
Study officials:
References:
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