louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT05380375: Short-course Antibiotic Treatment in AECOPD: a Meta-analysis of Double-blind Studies
Official title: Short-course Versus Very Short-course Antibiotic Treatment in Acute Exacerbations of COPD: a Meta-analysis of Double-blind Studies
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: COPD Exacerbation
Keywords: AECOPD
antibiotic treatment
meta analysis
short course
Forest plot
Lead sponsor: University of Monastir
Sponsor class: OTHER
First posted: 2022-05-18
Enrollment: 2
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: OTHER
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: We searched on the literature of controlled trials on Medline and Embase using the following search terms: COPD, antibiotic treatment and clinical trials. We also searched the reference lists of included studies for additional studies.

Brief summary: Chronic obstructive pulmonary disease (COPD) is a common disease worldwide and a leading cause of death and disability globally. Given that bacteria are implicated in a substantial proportion of acute exacerbation of COPD (AECOPD), antibiotics are frequently used. However, this current practice may lead to antibiotic overuse further increasing drug resistance and side effects. Although the small literature on interventions to prove the effective of short course of antibiotic, a metaanalysis of published randomised double-blind studies comparing the same antibiotics compared to a previous study is performed to determine whether a short course of antibiotic treatment is as effective as a very short course in patients with an exacerbation of COPD (EACOPD). The authors systematically searched electronic databases on the literature of controlled trials on Medline and Embase with no language, location, or time restrictions. The authors retrieved observational and controlled trials comparing different durations of the same oral antibiotic therapy in the treatment of acute exacerbations of COPD. The authors included 30 randomized, placebo-controlled trials for COPD patients. There was no statistically significant difference between shorter and longer antibiotic courses in early clinical success. In conclusion, Short-course antibiotic treatment is as effective as very short-course treatment in patients with mild to moderate exacerbations of chronic bronchitis and COPD.


Eligibility criteria: Inclusion Criteria:

* Studies considered eligible for inclusion were randomised trials of antibiotic intervention involving adult patients \>18 years of age with a diagnosis of AECOPD.

Exclusion Criteria:

* Studies not published in the English language or with more than two or different antibiotics were excluded

Primary outcomes:
measure: Clinical success
timeFrame: 30 days
Secondary outcomes:
Other outcomes:
Locations:
city: Monastir
country: Tunisia
facility: Semir Nouira
Study officials:
References:
Clinical trial NCT00829075: Impact of Three Different Gonadotrophin Regimes on Egg Donation Program
Official title: A Prospective, Randomized, Controlled Trial Comparing Three Different Gonadotrophin Regimens in Oocyte Donors: Ovarian Response and IVF Outcome
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE4
Conditions: Ovarian Stimulation
Lead sponsor: Instituto Valenciano de Infertilidad, IVI VALENCIA
Sponsor class: OTHER
First posted: 2009-01-26
Sex: FEMALE
Minimum age (years): 18
Maximum age (years): 34
Standard ages: ADULT
Accepts healthy volunteers: yes

Brief summary: Exploratory study assessing the effect of three gonadotrophin protocols on Controlled Ovarian Stimulation (COS) parameters and IVF outcome in oocyte donors undergoing GnRH analogue (long protocol). 1,028 donors were randomized in three groups: Group I (n= 346) only r-FSH, Group II (n= 333) only HP-hMG and Group III (n= 349) r-FSH plus HP-hMG. IVF outcome of 1,059 oocyte recipients was compared.


Eligibility criteria: Inclusion Criteria:

* healthy women 18-34 years of age
* regular menstrual cycles
* no family history of hereditary or chromosomal diseases
* normal karyotype
* BMI 18-29 Kg/m2
* negative screening for sexually transmitted diseases

Exclusion Criteria:

* women with PCOS were not included in this study

Primary outcomes:
measure: The aim of this study was to verify whether different gonadotrophin regimes could affect controlled ovarian stimulation (COS) parameters and IVF outcome in an egg donation program.
timeFrame: one year
Secondary outcomes:
Other outcomes:
Locations:
city: Valencia
country: Spain
facility: IVI Valencia
Study officials:
affiliation: IVI Valencia
name: Marco Melo, MDPhD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT03328975: An Evaluation of Blood Glucose Levels and Insulin Requirement After Subacromial Corticosteroid Injection in Insulin Dependent Diabetics
Official title: An Evaluation of Blood Glucose Levels and Insulin Requirement After Subacromial Corticosteroid Injection in Insulin Dependent Diabetics
Study type: INTERVENTIONAL
Overall status: WITHDRAWN
Phase: NA
Conditions: Shoulder Injury
Insulin-dependent Diabetics
Lead sponsor: University of Pittsburgh
Sponsor class: OTHER
First posted: 2017-11-01
Enrollment: 0
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The overall purpose of this study is to evaluate the effect of a corticosteroid shoulder injection on glucose levels in insulin-dependent diabetic men and women.


Eligibility criteria: Inclusion Criteria

* Insulin-dependent diabetic
* Age 18+
* Shoulder pain for over 4 weeks duration that is uncontrolled with activity modification or nonsteroidal anti-inflammatory drugs
* Use of glucometer for blood sugar monitoring
* Well controlled blood glucose levels
* Hemoglobin A1c less than or equal to 7.5

Exclusion Criteria

* Previous corticosteroid injection within the past 6 months
* Active infection
* Pregnant or plan on becoming pregnant
* Previous adverse event with corticosteroid or lidocaine use

Primary outcomes:
measure: Can diabetic patients maintain their blood glucose in a normal range after receiving a corticosteroid injection?
timeFrame: 4 weeks
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
References:
Clinical trial NCT06300775: Evaluation of Modified Hyrax Versus Quad Helix in Treatment of Posterior Cross Bite
Official title: A Comparative Evaluation of Modified Hyrax Versus Quad Helix in Treatment of Children With Posterior Cross Bite: Randomized Controlled Trial
Study type: INTERVENTIONAL
Overall status: RECRUITING
Phase: NA
Conditions: Posterior Cross Bite
Lead sponsor: Cairo University
Sponsor class: OTHER
First posted: 2024-03-08
Enrollment: 10
Sex: ALL
Minimum age (years): 6
Maximum age (years): 18
Standard ages: CHILD
ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Intervention model description: Modified Hyrax Versus Quad Helix
Primary purpose: TREATMENT

Brief summary: This study will be performed to evaluate the treatment of posterior cross-bite with modified hyrax \& Quad helix appliances and to compare which one will provide better results in relation to chewing difficulty in children with posterior cross- bite in mixed dentition

Detailed description: This study will be performed to evaluate the treatment of posterior cross-bite with modified hyrax \& Quad helix appliances and to compare which one will provide better results in relation to chewing difficulty as a primary outcome of this study and also evaluate the increase in the inter maxillary width , sleep apnea and signs \& symptoms of tempro-mandibular joints disorder in children with posterior cross- bite in mixed dentition Cases will be examined within a regular interval up to one year

Eligibility criteria: Inclusion Criteria:

* Children with posterior cross-bite in mixed dentition stage.
* Children with normal and mild growth pattern.
* Children with completely erupted upper first molars.

Exclusion Criteria:

* Children with advanced periodontal diseases.
* Children having general diseases, syndromes.
* Children with previous orthodontic.
* Children with severe horizontal growth patterns.

Primary outcomes:
measure: Chewing difficulty
timeFrame: one year
Secondary outcomes:
Other outcomes:
Locations:
city: Cairo
country: Egypt
facility: Cairo univeristry
Study officials:
References:
Clinical trial NCT06945575: Comparison of T-loop vs Opus Loop in Canine Retraction Efficacy and Anchorage Loss Control
Official title: Comparison of T-loop vs Opus Loop in Canine Retraction Efficacy and Anchorage Loss Control - a Split- Mouth, Randomized Clinical Trial
Study type: INTERVENTIONAL
Overall status: ACTIVE_NOT_RECRUITING
Phase: NA
Conditions: Space Closure, Orthodontic
Lead sponsor: Dow University of Health Sciences
Sponsor class: OTHER
First posted: 2025-04-25
Enrollment: 14
Sex: ALL
Minimum age (years): 14
Maximum age (years): 40
Standard ages: CHILD
ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The primary aim of this split-mouth randomized control trial is to compare the rate of canine retraction between the T loop and the Opus loop. The secondary objectives are to compare the angulation of the canine, changes in the first molar position in terms of anchorage loss, and molar rotation for the two loops used T-loop and Opus loop will be placed randomly on the right and left quadrants of patients for canine retraction and outcomes will be measured before and after completion of canine retraction

Detailed description: T-loop and Opus loop will be placed in the right and left quadrants of the patient for canine retraction after initial leveling and alignment. canine retraction rate will be measured by using a calibrated caliper every month. canine angulation will be evaluated by periapical x-ray which will be taken before and after completion of canine retraction and anchorage loss and molar rotation will be assessed by model analysis

Eligibility criteria: Inclusion Criteria:

Age between 14 -40 years Extractions of maxillary 1st premolars Class 1, 1/4th, 1/2, and 3/4th unit Class II molar relation Presence of all teeth up to the second molar Good oral hygiene

Exclusion Criteria:

Full cusp Class II Developmental, medical, or genetic problems Patient using bisphosphonates Spacing in dentition Grossly carious upper molars that cannot be restored Patient with active periodontal disease Severe crowding

Primary outcomes:
measure: Rate of canine retraction
timeFrame: From enrollment till end of treatment at 4 months
Secondary outcomes:
measure: Change in canine angulation at start of canine retraction and at the end of canine retraction
timeFrame: From enrollment till end of treatment at 4 months
measure: Change in anchorage loss before and after completion of canine retraction
timeFrame: From enrollment till end of treatment at 4 months
measure: Change in molar rotation at before and after completion of canine reatraction
timeFrame: From enrollment till end of treatment at 4 months
Other outcomes:
Locations:
city: Karachi
country: Pakistan
facility: Bahria University Health Sciences
state: Sindh
Study officials:
References:
Clinical trial NCT00319475: Evaluation of Mechanical Stapler for Aortic Anastomoses
Official title: Evaluation of Mechanical Stapler for Aortic Anastomoses
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Aortic Aneurysm, Abdominal
Leriche Syndrome
Lead sponsor: SVSE 2000 Ltd.
Sponsor class: INDUSTRY
First posted: 2006-04-27
Enrollment: 10
Sex: ALL
Minimum age (years): 21
Maximum age (years): 85
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NON_RANDOMIZED
Intervention model: SINGLE_GROUP
Primary purpose: TREATMENT

Brief summary: Demonstrate the safety and performance of the Aortic Stapler when used to attach a synthetic graft to an aorta in AAA and Leriche Syndrome patients


Eligibility criteria: Inclusion Criteria:

* Patient age is between 21 to 85 years old.
* Patient is diagnosed with Abdominal Aortic Aneurysm (AAA) or -aorto-Iliac/Femoral Occlusive Arterial Disease (Leriche' syndrome) by CT-Angio examination and/or angiography examination in patients with Leriche' syndrome.
* Patient with an aneurysm at the neck of the proximal or distal site that is between 5 to 10 mm and with a diameter of 16-22 mm.
* Patient is scheduled for AAA repair

Exclusion Criteria:

* Pregnant women
* Active malignancy
* Ruptured aneurysm
* Thoraco-AAA
* Patient with at least one of the following unstable risk factors:
* Renal disease (Cr \>2)
* Ischemic heart disease (unstable Angina)
* Obstructive Pulmonary Disease (contraindicated for open aortic surgery by respiratory function exam)
* Severe CHF (EF \< 25%)
* Patient with known allergy to metals or to the contrast media
* Participation in current or recent (within 60 days prior to surgery) clinical trial

Primary outcomes:
measure: Time to complete each stapled anastomosis.
Secondary outcomes:
measure: Post-operative follow up:
measure: no leakage
measure: no dilatation
measure: no fistula or hematoma at the anastomotic sites
Other outcomes:
Locations:
city: Duesseldorf
country: Germany
facility: Augusta Hospital
Study officials:
affiliation: Augusta Hospital, Berlin
name: Ralf Kolvenbach, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT01906775: Sub-threshold Pacing to Prevent Pacemaker-induced Ventricular Tachycardia
Official title: Sub-threshold Ventricular Back-up Pacing to Prevent Pacemaker-induced Ventricular Tachycardia
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Ventricular Tachyarrhythmias
ICD Shock Therapy
ICD Shock Burden
Keywords: ICD
ventricular tachyarrhythmia
shock
sub-threshold pacing
Lead sponsor: Johannes Gutenberg University Mainz
Sponsor class: OTHER
First posted: 2013-07-24
Enrollment: 550
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: CASE_ONLY
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Patients having an implanted ICD for secondary prevention of ventricular tachyarrhythmias. Patients are routinely under follow-up for device interrogation in our outpatient device department.

Patients with identified pacemaker-induced ventricular tachycardia were selected and after two or more episodes of VT, the ventricular back-up pacing was reprogrammed to a sub-threshold level.

Brief summary: Implantable cardioverter defibrillators (ICD) may have the capacity to provoke or worsen ventricular tachyarrhythmias (VT). It has been reported that ICD shocks by itself can increase mortality. This study aimed to determine the role of back-up pacing-induced VT (PIT) to the overall ICD shock burden by avoiding pause-related ventricular back-up pacing by programming the pacing output to a sub-threshold level for ineffective pacing.


Eligibility criteria: Inclusion Criteria:

* age \> 18 years
* implanted ICD
* occurrence of pacemaker-induced VT

Exclusion Criteria:

* documentation of pause-related syncope
* AV block
* sick-sinus syndrome
* younger than 18 years

Primary outcomes:
measure: Occurrence of VT requiring ICD shock
timeFrame: 48 months follow-up
Secondary outcomes:
measure: Type of arrhythmia / Number of arrhythmia
timeFrame: 48 months
Other outcomes:
measure: Incidence of PIT versus other VTs
timeFrame: 48 months
Locations:
city: Mainz
country: Germany
facility: University Hospital Mainz, II. Medical Clinic, Dept. of Electrophysiology
Study officials:
References:
citation: Theis C, Mollnau H, Sonnenschein S, Konrad T, Himmrich E, Bock K, Schulz E, Kampfner D, Gerhardt S, Quesada Ocete B, Munzel T, Rostock T. Reduction of ICD shock burden by eliminating back-up pacing induced ventricular tachyarrhythmias. J Cardiovasc Electrophysiol. 2014 Aug;25(8):889-895. doi: 10.1111/jce.12418. Epub 2014 May 2.
Clinical trial NCT03308175: Evaluation of the Effects of Flat and Modified Inclined Fixed Anterior Bite Planes on Mandibular Position in Growing Females With Skeletal Class 2 Malocclusion Due to Mandibular Deficiency and Deep Bite
Official title: Evaluation of the Effects of Flat and Modified Inclined Fixed Anterior Bite Planes on Mandibular Position in Growing Females With Skeletal Class 2 Malocclusion Due to Mandibular Deficiency and Deep Bite: A Randomized Controlled Trial
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Skeletal Class 2
Lead sponsor: Cairo University
Sponsor class: OTHER
First posted: 2017-10-12
Enrollment: 30
Sex: FEMALE
Minimum age (years): 10
Maximum age (years): 13
Standard ages: CHILD
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: This study will be conducted to see if unlocking mandible from deep bite in growing females by flat fixed anterior bite plane will change mandibular position in skeletal mandibular deficiency and if there is a difference in the change of mandibular position if we assisted the mandible by holding it in a more forward position by modified inclined fixed anterior bite plane .These results will be compared to normal mandibular growth from previous records of a matched control group in the discussion afterthat.

Detailed description: Two groups of patients the first for flat fixed anterior bite plane, the second for modified inclined fixed anterior bite plane.Full records are taken to patients. Then bands selection for upper first molars,impressions for upper arch with bands fitted and impression to lower arch, fabrication of either flat/ modified inclined fixed anterior bite planes and cementation in patient's mouth,evaluation of results after 8 months.

Eligibility criteria: Inclusion Criteria:

* (1)Growing females aged 10-13 (2)Skeletal maturational stage: stages 3,4 of the cervical maturational index CVMI.

  (3) low-angle/moderate normal growth pattern (4) Overjet of 4-7 mm as measured from labial surface of upper incisors to labial surface of lower incisors (5)Skeletal class 2 due to mandibular deficiency 77 degrees \<SNB\> 73 degrees (6) Normal or slightly protruded maxillary base (7) All cases had dental deep bite; with the upper incisors covering more than 50% of the height of the lower incisors.

  (8)Only deep bite cases that required extrusion of posterior teeth.

Exclusion Criteria:1- No syndromic or medically compromised patients 2- No growth disorders 3- No use of other appliances before or during the period of functional treatment

-

Primary outcomes:
measure: Change in mandibular position
timeFrame: 8 months
Secondary outcomes:
measure: Maxillary anteroposterior and vertical growth change.
timeFrame: 8 months
measure: Anteroposterior and vertical dental changes.
timeFrame: 8 months
Other outcomes:
Locations:
city: Cairo
country: Egypt
facility: Faculty of Dentistry,Cairo University
Study officials:
References:
Clinical trial NCT00562575: Evaluation of Safety and Effects of SLx-4090 After Dosing for 14 Days in Subjects With High Triglycerides
Official title: A Randomised, Double-blind, Placebo Controlled Study to Evaluate the Pharmacodynamics, Safety, Tolerability and Pharmacokinetics Profile of SLx-4090 Over 14 Days Dosing in Subjects With High Triglyceride Values
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE2
Conditions: Hypertriglyceridemia
Lead sponsor: Response Pharmaceuticals
Sponsor class: INDUSTRY
First posted: 2007-11-22
Enrollment: 24
Sex: ALL
Minimum age (years): 18
Maximum age (years): 65
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The purpose is to investigate the effect of oral doses of SLx-4090 over 14 days on subjects with high triglycerides.

Detailed description: 1. Serum triglycerides
2. Serum lipids and lipoproteins
3. Safety and tolerability

Eligibility criteria: Inclusion Criteria:

* Male or female subjects with high triglyceride levels
* Male or female subjects between age 18 and 65 years, inclusive

Exclusion Criteria:

* History of drug abuse
* Any prescribed or over the counter medication taken within 2 weeks prior to administration of study drug or within 6 times the elimination half-life
* Blood donation of more than 500ml blood in the previous 3 months
* Any confirmed significant allergic reaction against any drug or multiple allergies

Primary outcomes:
measure: Serum triglycerides
timeFrame: 14 days
Secondary outcomes:
measure: Adverse events and vital signs
timeFrame: 14 days
Other outcomes:
Locations:
city: Neuss
country: Germany
facility: FOCUS Clinical Drug Development GmbH
Study officials:
affiliation: FOCUS clinical Drug Development GmbH
name: Grit Anderson, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT02370875: rTMS and Botulinum Toxin in Benign Essential Blepharospasm
Official title: Combined Effects of rTMS and Botulinum Toxin in Benign Essential Blepharospasm: A Novel Approach
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Benign Essential Blepharospasm
Lead sponsor: University of Florida
Sponsor class: OTHER
First posted: 2015-02-25
Enrollment: 12
Sex: ALL
Minimum age (years): 30
Maximum age (years): 75
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: Benign essential blepharospasm (BEB) is a functionally disabling focal dystonia. Botulinum neurotoxin (BoNT) therapy is suboptimal in many BEB patients. Repetitious transcranial magnetic stimulation (rTMS) therapy is a promising noninvasive therapy and has shown positive benefits in BEB. rTMS therapy can be easily combined with BoNT injections to enhance the effects of BoNT in BEB.

Detailed description: A two week course of rTMS therapy to achieve sustained benefits will be employed. With standard BoNT treatment, the peak-dose benefits are seen at about 4-6 weeks after the administration of injections. rTMS will be introduced during this peak-dose period (about 6 weeks after BoNT or T1).The effects of combined therapy at about 10 weeks after BoNT injections (T2) and at about 12 weeks after BoNT injections (T3) will be examined along with the physiological effects at these time points.

Eligibility criteria: Inclusion Criteria:

* subjects diagnosed with blepharospasm or cranio-cervical dystonia who receive BoNT therapy at the Center for Movement Disorders will be approached. The investigators will enroll only those subjects who report experiencing positive benefits with BoNT but lasting about 10 weeks or less.

Exclusion Criteria:

* pregnancy
* active seizure disorder
* significant cognitive impairment
* exposure to neuroleptics
* presence of a metallic body such as pacemaker, implants, prosthesis, artificial limb or joint, shunt, metal rods and hearing aid.

Primary outcomes:
measure: Change in JRS Severity Score
timeFrame: 2 weeks after rTMS
measure: Change in JRS Frequency Score
timeFrame: 2 weeks after rTMS
measure: Change in Number of Sustained Forced Eye Blinks
timeFrame: 2 weeks after rTMS
measure: Change in Duration of Forced Blinks
timeFrame: 2 weeks after rTMS
Secondary outcomes:
measure: Change in CDQ-24 QOL Score
timeFrame: 2 weeks after rTMS
measure: Change in CDQ-24 ADL Subscore
timeFrame: 2 weeks after rTMS
measure: Change in Social Subscale of CDQ-24
timeFrame: 2 weeks after rTMS
Other outcomes:
Locations:
city: Gainesville
country: United States
facility: Center for Movement Disorders and Neurorestoration
state: Florida
Study officials:
affiliation: University of Florida
name: Aparna Wagle-Shukla, MD
role: PRINCIPAL_INVESTIGATOR
References: