Clinical trial NCT06359496: Split or Whole Liver Transplantation? A Multicenter Retrospective Cohort Study of Patients With Benign and Malignant Liver Disease
Official title: Split or Whole Liver Transplantation? A Multicenter Retrospective Cohort Study of Patients With Benign and Malignant Liver Disease
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Zhejiang University
Keywords: liver transplantation; propensity score matching; split; whole; hepatocellular carcinoma; prognosis
Lead sponsor: Zhejiang University
Sponsor class: OTHER
First posted: 2024-04-11
Enrollment: 1
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: COHORT
Time perspective: RETROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: Each organ donation and transplantation strictly followed the guidelines of the Ethics Committee of the two hospitals, the current regulation of the Chinese Government and the Declaration of Helsinki. Every precaution has been taken to protect the privacy of research subjects and the confidentiality of their personal information. Informed consent was obtained from all patients.

Brief summary: The primary objective of this study was to assess the safety and feasibility of split liver transplantation(SLT) for adult hepatocellular carcinoma (HCC) patients, while comparing the prognostic disparities between adult SLT and WLT also .

Liver transplantation (LT) is an effective treatment for end-stage liver disease. As a traditional marginal donor liver, the application of SLT in pediatric patients is successful.However, its application in adult liver transplantation, especially in HCC patients, remains controversial.

This retrospective study analyze outcomes among adults who underwent SLT and whole liver transplantation (WLT) at two centers from January 2018 to August 2022. A 1:1 propensity score matching (PSM) analysis was performed based on important donor and recipient variables. Baseline characteristics and postoperative outcomes of the above recipients were analyzed and compared. Statistical significance was determined using a two-sided p-value threshold of less than 0.05.

Detailed description: The primary objective of this study was to assess the safety and feasibility of split liver transplantation(SLT) for adult hepatocellular carcinoma (HCC) patients, while comparing the prognostic disparities between adult SLT and WLT also .

Liver transplantation (LT) is an effective treatment for end-stage liver disease. As a traditional marginal donor liver, the application of SLT in pediatric patients is successful.However, its application in adult liver transplantation, especially in HCC patients, remains controversial.

This retrospective study analyze outcomes among adults who underwent SLT and whole liver transplantation (WLT) at two centers from January 2018 to August 2022. A 1:1 propensity score matching (PSM) analysis was performed based on important donor and recipient variables. Baseline characteristics and postoperative outcomes of the above recipients were analyzed and compared. Statistical significance was determined using a two-sided p-value threshold of less than 0.05.

Eligibility criteria: Inclusion Criteria:

1. ≥ 18 years old
2. Received a liver transplantation between 2018 and 2022 (3) Liver transplantation was performed by SLT or WLT

Exclusion Criteria:

1. Re-LT
2. Multiorgan transplantation
3. Survival≤one week after LT
4. Incomplete data

Primary outcomes:
measure: Postoperative complications were evaluated by postoperative imaging reports and serological indicators
timeFrame: Jan.1 2018-Dec.31 2022
measure: The survival rate of each group was evaluated by follow-up survey and K-M curve
timeFrame: Jan.1 2018-Dec.31 2022
Secondary outcomes:
Other outcomes:
Locations:
city: Hangzhou
country: China
facility: Xiao Xu
Study officials:
References: