Clinical trial NCT07007286: Real-world Study on Liver Cancer Risk in Chronic Hepatitis B Patients With Family History of Liver Cancer
Official title: A Real-World Study on Reducing the Risk of Liver Cancer in Chronic Hepatitis B Patients With a Family History of HBV-Related Liver Cancer.
Study type: OBSERVATIONAL
Overall status: NOT_YET_RECRUITING
Conditions: HBV
HCC
Lead sponsor: Peking University First Hospital
Sponsor class: OTHER
First posted: 2025-06-05
Enrollment: 1500
Sex: ALL
Minimum age (years): 30
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Patients who meet the inclusion criteria but do not meet the exclusion criteria were screened from multiple centers nationwide.

Brief summary: This study is a prospective, multicenter, real-world cohort study designed to compare the long-term outcomes of chronic hepatitis B patients with a family history of HBV-related hepatocellular carcinoma (HCC) who receive PEG IFNα-2b combined with nucleos(t)ide analogues or nucleos(t)ide monotherapy. The primary endpoint is the incidence rate of HCC, and secondary endpoints include the rate of HBsAg seroclearance, changes in liver fibrosis, and survival rates. The study will last for 5 years and enroll approximately 15,000 patients, aiming to provide evidence-based optimization for CHB treatment regimens.


Eligibility criteria: Inclusion Criteria:

* (1) Chronic hepatitis B (CHB) patients with HBsAg positivity for over 6 months; (2) Family history of HBV-related hepatocellular carcinoma (HCC) (first- or second-degree relatives with HBV-related HCC); (3) Age ≥ 30 years, regardless of gender; (4) Based on real-world clinical practice, patients receiving nucleos(t)ide analogue (NA) therapy, such as Entecavir (ETV), Tenofovir Disoproxil Fumarate (TDF), Tenofovir Alafenamide Fumarate (TAF), or Tenofovir Amibufenamide (TMF), or those receiving combination therapy with nucleos(t)ide analogues and PEG IFNα-2b; (5) Negative pregnancy test within 24 hours before the first dose (for women of childbearing potential); (6) Voluntary participation, with the ability to understand and sign the informed consent form.

Exclusion Criteria:

* (1) Patients diagnosed with hepatocellular carcinoma (HCC) or malignancies in other organ systems prior to treatment; (2) Patients with contraindications to Peg IFN α-2b (refer to the Guidelines for the Prevention and Treatment of Chronic Hepatitis B (2022 Edition) for details); (3) Patients in the immune-tolerant phase of HBV infection; (4) Patients scheduled for or with a history of organ transplantation; (5) Patients with hypersensitivity to interferon or any contraindication listed in the drug's prescribing information; (6) Other conditions deemed unsuitable for enrollment by the investigator.

Primary outcomes:
measure: 5-year incidence of hepatocellular carcinoma (HCC)
timeFrame: From the start of antiviral treatment to 5 years of follow-up.
Secondary outcomes:
measure: HBsAg seroclearance rate
timeFrame: From the start of antiviral treatment to 5 years of follow-up.
measure: HBeAg seroclearance rate
timeFrame: From the start of antiviral treatment to 5 years of follow-up.
measure: HBV DNA level
timeFrame: From the start of antiviral treatment to 5 years of follow-up.
measure: HBsAg level
timeFrame: From the start of antiviral treatment to 5 years of follow-up.
measure: HBeAg level
timeFrame: From the start of antiviral treatment to 5 years of follow-up.
measure: Proportion of patients with improved or progressed liver fibrosis
timeFrame: From the start of antiviral treatment to 5 years of follow-up.
measure: Median time to cirrhosis
timeFrame: From the start of antiviral treatment to 5 years of follow-up.
measure: Median time to decompensated cirrhosis
timeFrame: From the start of antiviral treatment to 5 years of follow-up.
measure: Median time to HCC
timeFrame: From the start of antiviral treatment to 5 years of follow-up.
measure: Overall survival (OS)
timeFrame: From the start of antiviral treatment to 5 years of follow-up.
Other outcomes:
Locations:
city: Heilongjiang
country: China
facility: Qitaihe Infectious Disease Hospital
state: Heilongjiang
city: Yizheng
country: China
facility: Yizheng People's Hospital
state: Jiangsu
city: Changle
country: China
facility: Changle County People's Hospital
state: Shandong
city: Junxian
country: China
facility: Juxian People's Hospital
state: Shandong
city: Pingdu
country: China
facility: Pingdu People's Hospital, Shandong
state: Shandong
city: Zouping
country: China
facility: Zouping People's Hospital
state: Shandong
city: Huozhou
country: China
facility: Huozhou Coal & Electricity Group General Hospital Co., Ltd.
state: Shanxi
city: Huozhou
country: China
facility: Huozhou People's Hospital, Huozhou Medical Group
state: Shanxi
city: Huozhou
country: China
facility: Huozhou People's Hospital
state: Shanxi
city: Jiexiu
country: China
facility: Fenxi Mining Group Employees General Hospital
state: Shanxi
city: Jiexiu
country: China
facility: Jiexiu Medical Group People's Hospital
state: Shanxi
city: Anfu
country: China
facility: Anfu County People's Hospital
city: Ankang
country: China
facility: Ankang Central Hospital
city: Ankang
country: China
facility: Ankang Hospital of Traditional Chinese Medicine
city: Anning
country: China
facility: Anning Hospital of Traditional Chinese Medicine
city: Anqing
country: China
facility: Anqing First People's Hospital
city: Anqing
country: China
facility: Anqing Municipal Hospital
city: Anshan
country: China
facility: Anshan Infectious Disease Hospital
city: Anyue
country: China
facility: Anyue County People's Hospital
city: Baise
country: China
facility: Affiliated Hospital of Youjiang Medical University for Nationalities
city: Baoding
country: China
facility: Baoding First Central Hospital
city: Baoding
country: China
facility: Baoding People's Hospital
city: Baotou
country: China
facility: Baotou Central Hospital
city: Baotou
country: China
facility: China National Medicines (CNM) Northern Hospital
city: Baotou
country: China
facility: The Third Staff Hospital of Baotou Steel Group
city: Beihai
country: China
facility: Beihai People's Hospital
city: Beijing
country: China
facility: Beijing Daxing District People's Hospital
city: Beijing
country: China
facility: Beijing Ditan Hospital, Capital Medical University
city: Beijing
country: China
facility: Beijing Ditan Hospital
city: Beijing
country: China
facility: Beijing Fangshan District First Hospital
city: Beijing
country: China
facility: Beijing Hospital of Traditional Chinese Medicine, Capital Medical University
city: Beijing
country: China
facility: Beijing Huaxin Hospital
city: Beijing
country: China
facility: Beijing Liangxiang Hospital, Fangshan District
city: Beijing
country: China
facility: Beijing Tsinghua Changgung Hospital
city: Beijing
country: China
facility: Beijing You'an Hospital, Capital Medical University
city: Beijing
country: China
facility: Beijing You'an Hospital
city: Beijing
country: China
facility: Dongfang Hospital, Beijing University of Chinese Medicine
city: Beijing
country: China
facility: Dongzhimen Hospital, Beijing University of Chinese Medicine
city: Beijing
country: China
facility: Peking University People's Hospital
city: Beijing
country: China
facility: Peking University Third Hospital
city: Beijing
country: China
facility: Shunyi Hospital of Traditional Chinese Medicine, Beijing
city: Beijing
country: China
facility: The Fifth Medical Center of PLA General Hospital
city: Beijing
country: China
facility: Wangfu Hospital of Integrated Traditional Chinese and Western Medicine
city: Beijing
country: China
facility: Xiyuan Hospital, China Academy of Chinese Medical Sciences
city: Beijing
country: China
facility: Xuanwu Hospital, Capital Medical University
city: Bengbu
country: China
facility: Bengbu Fifth People's Hospital
city: Bengbu
country: China
facility: Guzhen County Hospital of Traditional Chinese Medicine
city: Bengbu
country: China
facility: Guzhen County People's Hospital
city: Bengbu
country: China
facility: The First Affiliated Hospital of Bengbu Medical University
city: Benxi
country: China
facility: Benxi Sixth People's Hospital
city: Bihua
country: China
facility: Beihai Tuberculosis Prevention and Treatment Hospital
city: Binzhou
country: China
facility: Binzhou Central Hospital
city: Binzhou
country: China
facility: Binzhou People's Hospital
city: Bozhou
country: China
facility: Bozhou Hospital of Traditional Chinese Medicine
city: Bozhou
country: China
facility: Bozhou People's Hospital
city: Bozhou
country: China
facility: Lixin County People's Hospital
city: Bozhou
country: China
facility: Mengcheng First People's Hospital
city: Cangzhou
country: China
facility: Cangzhou Third Hospital
city: Changchun
country: China
facility: The First Hospital of Jilin University
city: Changji
country: China
facility: Changji Branch of the First Affiliated Hospital of Xinjiang Medical University
city: Changji
country: China
facility: Changji Hui Autonomous Prefecture People's Hospital
city: Changxing
country: China
facility: Changxing County People's Hospital
city: Changzhi
country: China
facility: Changzhi People's Hospital
city: Changzhi
country: China
facility: Heping Hospital Affiliated to Changzhi Medical College
city: Changzhou
country: China
facility: Changzhou Third People's Hospital
city: Changzhou
country: China
facility: Yizheng People's Hospital
city: Chaoyang
country: China
facility: Chaoyang Fourth Hospital
city: Chaoyang
country: China
facility: Kazuo County Central Hospital
city: Chengdu
country: China
facility: Chengdu Fifth People's Hospital
city: Chengdu
country: China
facility: Chengdu Public Health Clinical Medical Center
city: Chengdu
country: China
facility: Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital
city: Chengdu
country: China
facility: West China Hospital, Sichuan University
city: Chifeng
country: China
facility: Chifeng Baoshan Hospital
city: Chifeng
country: China
facility: Chifeng Songshan Traditional Chinese Medicine & Mongolian Medicine Hospital
city: Chifeng
country: China
facility: Chifeng Tumor Hospital
city: Chizhou
country: China
facility: Chizhou People's Hospital
city: Chuzhou
country: China
facility: Mingguang People's Hospital
city: Dalian
country: China
facility: The First Affiliated Hospital of Dalian Medical University
city: Dali
country: China
facility: Dali Bai Autonomous Prefecture People's Hospital
city: Dandong
country: China
facility: Dandong Sixth People's Hospital
city: Daqing
country: China
facility: Daqing Second Hospital
city: Datong
country: China
facility: China National Medicines & Health Products Datong Coal Mine Group General Hospital
city: Datong
country: China
facility: Datong Fourth People's Hospital
city: Donggang
country: China
facility: Donggang Central Hospital
city: Dongguan
country: China
facility: Dongguan Eastern Central Hospital
city: Dongguan
country: China
facility: Dongguan Ninth People's Hospital
city: Dongtai
country: China
facility: Dongtai People's Hospital
city: Dongying
country: China
facility: Dongying Hospital of Traditional Chinese Medicine
city: Dongying
country: China
facility: Dongying People's Hospital
city: Dongying
country: China
facility: Shengli Oilfield Central Hospital
city: Enshi
country: China
facility: Jianshi County People's Hospital
city: Enshi
country: China
facility: Lichuan Traditional Chinese Medicine Hospital for Ethnic Minorities
city: Ezhou
country: China
facility: Ezhou Central Hospital
city: Fengcheng
country: China
facility: Fengcheng People's Hospital
city: Fenyang
country: China
facility: Fenyang Hospital
city: Foshan
country: China
facility: Foshan Hospital of Traditional Chinese Medicine
city: Foshan
country: China
facility: Sanshui Hospital of Zhujiang Hospital, Southern Medical University
city: Foshan
country: China
facility: Shunde Hospital Affiliated to Jinan University
city: Foshan
country: China
facility: The Eighth Affiliated Hospital of Southern Medical University
city: Foshan
country: China
facility: The Fourth People's Hospital of Foshan
city: Fuxin
country: China
facility: Fuxin Infectious Disease Hospital
city: Fuyang
country: China
facility: Fuyang Fifth People's Hospital
city: Fuyang
country: China
facility: Fuyang Hospital Affiliated to Anhui Medical University
city: Fuyang
country: China
facility: Fuyang People's Hospital
city: Fuyang
country: China
facility: Fuyang Second People's Hospital
city: Fuyang
country: China
facility: Linquan County People's Hospital
city: Fuyang
country: China
facility: Taihe County Hospital of Traditional Chinese Medicine
city: Fuzhou
country: China
facility: Jinxi County People's Hospital
city: Fuzhou
country: China
facility: Lichuan County People's Hospital
city: Fuzhou
country: China
facility: Linchuan District First People's Hospital
city: Fuzhou
country: China
facility: Nanfeng County People's Hospital
city: Fuzhou
country: China
facility: The First Affiliated Hospital of Fujian Medical University
city: Ganzhou
country: China
facility: Dingnan County First People's Hospital
city: Ganzhou
country: China
facility: Ganzhou Fifth People's Hospital
city: Ganzhou
country: China
facility: Ganzhou People's Hospital
city: Ganzhou
country: China
facility: Yudu County People's Hospital
city: Gaomi
country: China
facility: Gaomi People's Hospital
city: Guangzhou
country: China
facility: Guangzhou Eighth People's Hospital, Guangzhou Medical University
city: Guangzhou
country: China
facility: Guangzhou First People's Hospital
city: Guangzhou
country: China
facility: Guangzhou Medical University Affiliated Panyu Central Hospital
city: Guangzhou
country: China
facility: Huadu District People's Hospital, Guangzhou
city: Guangzhou
country: China
facility: Nansha District People's Hospital, Guangzhou
city: Guangzhou
country: China
facility: Panyu District Maternal and Child Health Hospital, Guangzhou
city: Guangzhou
country: China
facility: Shijing People's Hospital, Baiyun District, Guangzhou
city: Guangzhou
country: China
facility: The Fourth Affiliated Hospital of Guangzhou Medical University
city: Guangzhou
country: China
facility: The Third Affiliated Hospital of Guangzhou Medical University
city: Guangzhou
country: China
facility: The Third Affiliated Hospital of Southern Medical University
city: Guilin
country: China
facility: Guilin Hospital of Traditional Chinese Medicine
city: Guilin
country: China
facility: The Third People's Hospital of Guilin
city: Guilin
country: China
facility: Xing'an County People's Hospital
city: Haikou
country: China
facility: Hainan Provincial People's Hospital
city: Hailin
country: China
facility: Hailin People's Hospital
city: Hami
country: China
facility: Hami Central Hospital
city: Hami
country: China
facility: Xinjiang Production and Construction Corps 13th Division Hongxing Hospital
city: Handan
country: China
facility: Handan Central Hospital
city: Handan
country: China
facility: Handan First Hospital
city: Handan
country: China
facility: Handan Fourth Hospital
city: Handan
country: China
facility: Handan Infectious Disease Hospital
city: Handan
country: China
facility: Linzhang County People's Hospital
city: Handan
country: China
facility: Wei County People's Hospital
city: Handan
country: China
facility: Yongnian District First People's Hospital
city: Hangzhou
country: China
facility: Hangzhou Xixi Hospital
city: Hangzhou
country: China
facility: Lin'an District First People's Hospital
city: Hangzhou
country: China
facility: Linping District Hospital of Traditional Chinese Medicine
city: Hangzhou
country: China
facility: The Second Affiliated Hospital of Zhejiang Chinese Medical University
city: Hanzhong
country: China
facility: Chenggu County People's Hospital
city: Hanzhong
country: China
facility: Hanbin District First Hospital
city: Hanzhong
country: China
facility: Hanzhong Second People's Hospital
city: Hanzhong
country: China
facility: Yang County People's Hospital
city: Harbin
country: China
facility: Acheng District People's Hospital of Harbin
city: Harbin
country: China
facility: Harbin First Hospital
city: Harbin
country: China
facility: Harbin Sixth Hospital
city: Harbin
country: China
facility: Heilongjiang Provincial Hospital
city: Harbin
country: China
facility: The First Affiliated Hospital of Harbin Medical University
city: Harbin
country: China
facility: The Fourth Affiliated Hospital of Harbin Medical University
city: Harbin
country: China
facility: The Second Affiliated Hospital of Harbin Medical University
city: Hebei
country: China
facility: Gu'an County Hospital of Traditional Chinese Medicine
city: Hefei
country: China
facility: Anhui Provincial Hospital
city: Hefei
country: China
facility: Hefei First People's Hospital Binhu Branch
city: Hefei
country: China
facility: Hefei First People's Hospital
city: Hefei
country: China
facility: Hefei Second People's Hospital
city: Hefei
country: China
facility: Hefei Third People's Hospital
city: Hefei
country: China
facility: The First Affiliated Hospital of Anhui Medical University
city: Hegang
country: China
facility: Hegang Infectious Disease Hospital
city: Hegang
country: China
facility: Hegang Mining General Hospital
city: Heihe
country: China
facility: Beian First People's Hospital
city: Heihe
country: China
facility: Heihe First People's Hospital
city: Hengshui
country: China
facility: Hengshui Third People's Hospital
city: Hetian
country: China
facility: Hotan Prefecture Specialized Hospital for Infectious Diseases
city: Heze
country: China
facility: Heze Municipal Hospital
city: Hezhou
country: China
facility: Hezhou People's Hospital
city: Hohhot
country: China
facility: Affiliated Hospital of Inner Mongolia Medical University
city: Hohhot
country: China
facility: Hohhot Second Hospital
city: Hohhot
country: China
facility: Inner Mongolia Autonomous Region Hospital of Traditional Chinese Medicine
city: Hohhot
country: China
facility: The 969th Hospital of the Joint Logistics Support Force
city: Hohhot
country: China
facility: The Fourth Hospital of Inner Mongolia Autonomous Region
city: Huai'an
country: China
facility: Hongze District People's Hospital
city: Huai'an
country: China
facility: Huai'an Fifth People's Hospital
city: Huai'an
country: China
facility: Huai'an Fourth People's Hospital
city: Huai'an
country: China
facility: Huai'an No. 82 Hospital
city: Huainan
country: China
facility: Huainan First People's Hospital
city: Huangshan
country: China
facility: Huangshan Huangshan People's Hospital
city: Huangshan
country: China
facility: Huangshan People's Hospital
city: Huangshan
country: China
facility: Qimen County People's Hospital
city: Huangshan
country: China
facility: Xiuning County People's Hospital
city: Huangshi
country: China
facility: Daye People's Hospital
city: Huangshi
country: China
facility: Huangshi Central Hospital
city: Huangshi
country: China
facility: Huangshi Hospital of Traditional Chinese Medicine
city: Huangshi
country: China
facility: Yangxin County People's Hospital
city: Hubei
country: China
facility: Huazhong University of Science and Technology
city: Ji'an
country: China
facility: Ji'an Central People's Hospital
city: Jiamusi
country: China
facility: Jiamusi Infectious Disease Hospital
city: Jiangmen
country: China
facility: Jiangmen Central Hospital
city: Jiangmen
country: China
facility: Xinhui People's Hospital
city: Jianping
country: China
facility: Jianping County Hospital
city: Jiaozhou
country: China
facility: Tongji University Affiliated Oriental Hospital Jiaozhou
city: Jilin
country: China
facility: Affiliated Hospital of Beihua University
city: Jilin
country: China
facility: Jilin City Infectious Disease Hospital
city: Jilin
country: China
facility: Jilin Provincial Hepatobiliary Hospital
city: Jimo
country: China
facility: Qingdao Jimo District People's Hospital
city: Jinan
country: China
facility: Jinan People's Hospital
city: Jinan
country: China
facility: Jiyang District Hospital of Traditional Chinese Medicine
city: Jinan
country: China
facility: Shandong Provincial Hospital Affiliated to Shandong First Medical University
city: Jinan
country: China
facility: Shandong Provincial Public Health Clinical Center
city: Jinan
country: China
facility: The First Affiliated Hospital of Shandong First Medical University
city: Jinan
country: China
facility: The Second Hospital of Shandong University
city: Jincheng
country: China
facility: Gaoping People's Hospital
city: Jincheng
country: China
facility: Jincheng People's Hospital
city: Jincheng
country: China
facility: Jincheng Third People's Hospital
city: Jincheng
country: China
facility: Zezhou County People's Hospital
city: Jingzhou
country: China
facility: Gong'an County People's Hospital
city: Jingzhou
country: China
facility: Jingzhou Central Hospital
city: Jingzhou
country: China
facility: The First People's Hospital of Jingzhou, Hubei
city: Jinhua
country: China
facility: Jinhua Municipal Central Hospital
city: Jining
country: China
facility: Jining Public Health Medical Center
city: Jining
country: China
facility: Jinxiang County People's Hospital
city: Jinxian
country: China
facility: Jinxian County People's Hospital
city: Jinzhong
country: China
facility: Jinzhong First People's Hospital
city: Jinzhong
country: China
facility: Shanxi Coking Coal Fenxi Mining Group Employees General Hospital
city: Jinzhou
country: China
facility: Jinzhou Central Hospital
city: Jinzhou
country: China
facility: Jinzhou Infectious Disease Hospital
city: Jiujiang
country: China
facility: Jiujiang Hospital of Traditional Chinese Medicine
city: Jiujiang
country: China
facility: Jiujiang Third People's Hospital
city: Jixi
country: China
facility: Jixi Infectious Disease Hospital
city: Karamay
country: China
facility: Karamay Central Hospital
city: Kunming
country: China
facility: Yunnan Provincial People's Hospital
city: Laixi
country: China
facility: Laixi People's Hospital
city: Laizhou
country: China
facility: Laizhou People's Hospital
city: Lanzhou
country: China
facility: Lanzhou Petrochemical General Hospital
city: Lanzhou
country: China
facility: Lanzhou Second People's Hospital
city: Lanzhou
country: China
facility: The Second Hospital of Lanzhou University
city: Lianyungang
country: China
facility: Dongfang Hospital of Lianyungang
city: Lianyungang
country: China
facility: Guanyun County Hospital of Traditional Chinese Medicine
city: Lianyungang
country: China
facility: Guanyun County People's Hospital
city: Lianyungang
country: China
facility: Lianyungang Dongfang Hospital
city: Lianyungang
country: China
facility: Lianyungang First People's Hospital
city: Linfen
country: China
facility: Houma People's Hospital
city: Linfen
country: China
facility: Linfen Central Hospital
city: Linfen
country: China
facility: Linfen Second People's Hospital
city: Linfen
country: China
facility: Linfen Third People's Hospital
city: Linfen
country: China
facility: Xiangfen County People's Hospital
city: Linfen
country: China
facility: Yaodu District People's Hospital
city: Linkou
country: China
facility: Linkou County People's Hospital
city: Linxia
country: China
facility: Hezheng County People's Hospital
city: Linyi
country: China
facility: Linyi Hospital of Traditional Chinese Medicine
city: Linyi
country: China
facility: Linyi People's Hospital
city: Lishui
country: China
facility: Lishui Central Hospital
city: Liuzhou
country: China
facility: Liuzhou People's Hospital
city: Liuzhou
country: China
facility: Liuzhou Workers' Hospital
city: Longnan
country: China
facility: Longnan First People's Hospital
city: Longyan
country: China
facility: Liancheng County Hospital
city: Longyan
country: China
facility: Longyan People's Hospital
city: Longyan
country: China
facility: Longyan Second Hospital
city: Longyan
country: China
facility: Tingzhou Hospital of Changting County
city: Longyan
country: China
facility: Wuping County Hospital
city: Lu'an
country: China
facility: Affiliated Hospital of West Anhui Health Vocational College
city: Lu'an
country: China
facility: Huoqiu First People's Hospital
city: Lu'an
country: China
facility: Huoqiu Second People's Hospital
city: Lu'an
country: China
facility: Huoshan County Hospital
city: Lu'an
country: China
facility: Jinzhai County Hospital of Traditional Chinese Medicine
city: Lu'an
country: China
facility: Lu'an Fourth People's Hospital
city: Lu'an
country: China
facility: Lu'an Hospital of Traditional Chinese Medicine
city: Lu'an
country: China
facility: Lu'an People's Hospital
city: Lu'an
country: China
facility: Lu'an Yeji District People's Hospital
city: Lüliang
country: China
facility: Lvliang People's Hospital
city: Lüliang
country: China
facility: Wenshui County People's Hospital
city: Ma'anshan
country: China
facility: Ma'anshan Fourth People's Hospital
city: Ma'anshan
country: China
facility: The Second Affiliated Hospital of Wannan Medical College
city: Macheng
country: China
facility: Macheng People's Hospital
city: Maoming
country: China
facility: Huazhou People's Hospital
city: Meishan
country: China
facility: Meishan People's Hospital
city: Mudanjiang
country: China
facility: Mudanjiang Kang'an Hospital
city: Mudanjiang
country: China
facility: Mudanjiang Second People's Hospital
city: Nanchang
country: China
facility: Jiangxi Provincial People's Hospital
city: Nanchang
country: China
facility: Nanchang County People's Hospital
city: Nanchang
country: China
facility: Nanchang Ninth Hospital
city: Nanchang
country: China
facility: The First Affiliated Hospital of Nanchang University
city: Nanchang
country: China
facility: The Second Affiliated Hospital of Nanchang University
city: Nanchong
country: China
facility: Nanbu County People's Hospital
city: Nangong
country: China
facility: Nangong People's Hospital
city: Nanjing
country: China
facility: Jiangsu Provincial People's Hospital
city: Nanjing
country: China
facility: Lishui District People's Hospital
city: Nanjing
country: China
facility: Nanjing Drum Tower Hospital
city: Nanjing
country: China
facility: Nanjing Hospital of Traditional Chinese Medicine
city: Nanjing
country: China
facility: Nanjing Second Hospital
city: Nanjing
country: China
facility: Nanjing Tianyinshan Hospital
city: Nanjing
country: China
facility: Qinhuai Medical District of Eastern Theater General Hospital
city: Nanjing
country: China
facility: The Fourth Affiliated Hospital of Nanjing Medical University
city: Nanjing
country: China
facility: Zhongda Hospital
city: Nanning
country: China
facility: The First Affiliated Hospital of Guangxi Medical University
city: Nanning
country: China
facility: The First Affiliated Hospital of Guangxi University of Chinese Medicine
city: Nanning
country: China
facility: The Second Affiliated Hospital of Guangxi Medical University
city: Nanning
country: China
facility: The Second People's Hospital of Nanning
city: Nanping
country: China
facility: Jianyang First Hospital of Nanping
city: Nanping
country: China
facility: Nanping First Hospital
city: Nanping
country: China
facility: Zhenghe County Hospital
city: Nantong
country: China
facility: Affiliated Hospital of Nantong University
city: Nantong
country: China
facility: Haimen District People's Hospital
city: Nantong
country: China
facility: Nantong Third People's Hospital
city: Nantong
country: China
facility: Qidong Third People's Hospital
city: Neimeng
country: China
facility: Bairin Left Banner People's Hospital
city: Neimeng
country: China
facility: Hulunbuir People's Hospital
city: Neimeng
country: China
facility: Morin Dawa Daur Autonomous Banner People's Hospital
city: Ningbo
country: China
facility: Beilun District Hospital of Traditional Chinese Medicine
city: Ningbo
country: China
facility: Ningbo Second Hospital
city: Ningcheng
country: China
facility: Ningcheng County Central Hospital
city: Ordos
country: China
facility: Ordos Second People's Hospital
city: Panjin
country: China
facility: Panjin Third People's Hospital
city: Pingliang
country: China
facility: Affiliated Hospital of Gansu Medical College
city: Pingliang
country: China
facility: Huating Second People's Hospital
city: Pingliang
country: China
facility: Zhuanglang County People's Hospital
city: Pingxiang
country: China
facility: Pingxiang People's Hospital
city: Pingyang
country: China
facility: Pingyang County People's Hospital
city: Putian
country: China
facility: Affiliated Hospital of Putian University
city: Putian
country: China
facility: Putian First People's Hospital
city: Putian
country: China
facility: Putian Hanjiang Hospital
city: Qingdao
country: China
facility: Huangdao District People's Hospital
city: Qingdao
country: China
facility: Qingdao Eighth People's Hospital
city: Qingdao
country: China
facility: Qingdao Public Health Clinical Center
city: Qingdao
country: China
facility: The Affiliated Hospital of Qingdao University
city: Qingyuan
country: China
facility: Lianzhou People's Hospital
city: Qingyuan
country: China
facility: Qingyuan People's Hospital
city: Qingyuan
country: China
facility: The Second People's Hospital of Northern Guangdong
city: Qingyuan
country: China
facility: Yangshan County People's Hospital
city: Qingyuan
country: China
facility: Yingde People's Hospital
city: Qingzhou
country: China
facility: Qingzhou People's Hospital
city: Qingzhou
country: China
facility: Weifang Yidu Central Hospital
city: Qinhuangdao
country: China
facility: Qinhuangdao Third Hospital
city: Qinzhou
country: China
facility: The First People's Hospital of Qinzhou
city: Qinzhou
country: China
facility: The Second People's Hospital of Qinzhou
city: Qiqihar
country: China
facility: Qiqihar Seventh Hospital
city: Quanzhou
country: China
facility: Anxi County Hospital of Traditional Chinese Medicine
city: Quanzhou
country: China
facility: Anxi County Hospital
city: Quanzhou
country: China
facility: Dehua County Hospital of Traditional Chinese Medicine
city: Quanzhou
country: China
facility: Huian County Hospital of Traditional Chinese Medicine
city: Quanzhou
country: China
facility: Jinjiang Hospital
city: Quanzhou
country: China
facility: Nan'an Haidu Hospital
city: Quanzhou
country: China
facility: Quangang District Hospital, Quanzhou
city: Quanzhou
country: China
facility: Quanzhou Hospital of Traditional Chinese Medicine
city: Quanzhou
country: China
facility: Shishi Hospital
city: Quanzhou
country: China
facility: The 910th Hospital of the Joint Logistics Support Force
city: Quanzhou
country: China
facility: The Second Affiliated Hospital of Fujian Medical University
city: Quanzhou
country: China
facility: Yongchun County Hospital
city: Rizhao
country: China
facility: Rizhao Central Hospital
city: Rizhao
country: China
facility: Rizhao People's Hospital
city: Rui'an
country: China
facility: Rui'an Second People's Hospital
city: Sanming
country: China
facility: Ninghua County General Hospital
city: Sanming
country: China
facility: Sanming First People's Hospital
city: Sanming
country: China
facility: Sanming Hospital of Integrated Traditional Chinese and Western Medicine
city: Sanming
country: China
facility: Sanming Second People's Hospital
city: Sanming
country: China
facility: Youxi County General Hospital, Sanming
city: Sanming
country: China
facility: Youxi County Hospital of Traditional Chinese Medicine, Sanming
city: Shandong
country: China
facility: Qilu Hospital of Shandong University
city: Shangcheng
country: China
facility: Shucheng People's Hospital
city: Shanghai
country: China
facility: Minhang District Central Hospital of Shanghai
city: Shanghai
country: China
facility: Renji Hospital Affiliated to Shanghai Jiao Tong University School of Medicine
city: Shanghai
country: China
facility: Shanghai General Hospital
city: Shanghai
country: China
facility: Shanghai Jiao Tong University School of Medicine
city: Shanghai
country: China
facility: Shanghai Public Health Clinical Center
city: Shanghai
country: China
facility: Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine
city: Shanghai
country: China
facility: Tongji Hospital Affiliated to Tongji University
city: Shangli
country: China
facility: Shangli County People's Hospital
city: Shangrao
country: China
facility: Guangxin District People's Hospital
city: Shangrao
country: China
facility: Shangrao Central Hospital
city: Shangrao
country: China
facility: Shangrao People's Hospital
city: Shangrao
country: China
facility: Shangrao Second People's Hospital
city: Shangrao
country: China
facility: Wuyuan County People's Hospital
city: Shawan
country: China
facility: Shawan City People's Hospital
city: Shenyang
country: China
facility: Shengjing Hospital of China Medical University
city: Shenyang
country: China
facility: The 242 Hospital Affiliated to Shenyang Medical College
city: Shenyang
country: China
facility: The First Affiliated Hospital of China Medical University
city: Shenzhen
country: China
facility: Bao'an District People's Hospital, Shenzhen
city: Shenzhen
country: China
facility: Bao'an District Traditional Chinese Medicine Hospital, Shenzhen
city: Shenzhen
country: China
facility: Fuyong People's Hospital, Bao'an District, Shenzhen
city: Shenzhen
country: China
facility: Longgang Central Hospital, Shenzhen
city: Shenzhen
country: China
facility: Longgang District People's Hospital, Shenzhen
city: Shenzhen
country: China
facility: Longhua District People's Hospital, Shenzhen
city: Shenzhen
country: China
facility: Nanshan District People's Hospital, Shenzhen
city: Shenzhen
country: China
facility: Peking University Shenzhen Hospital
city: Shenzhen
country: China
facility: Shenzhen Fourth People's Hospital
city: Shenzhen
country: China
facility: Shenzhen Hospital of Southern Medical University
city: Shenzhen
country: China
facility: Shenzhen People's Hospital
city: Shenzhen
country: China
facility: Shenzhen Third People's Hospital
city: Shenzhen
country: China
facility: Songgang People's Hospital, Bao'an District, Shenzhen
city: Shenzhen
country: China
facility: Southern Medical University Shenzhen Hospital
city: Shenzhen
country: China
facility: The Eighth Affiliated Hospital of Sun Yat-sen University
city: Shenzhen
country: China
facility: The Seventh Affiliated Hospital of Sun Yat-sen University
city: Shenzhen
country: China
facility: Yantian District People's Hospital, Shenzhen
city: Shijiazhuang
country: China
facility: The First Hospital of Hebei Medical University
city: Shiyan
country: China
facility: Sinopharm Dongfeng General Hospital
city: Shouguang
country: China
facility: Shouguang People's Hospital
city: Sichuan
country: China
facility: Qionglai Medical Center Hospital
city: Songyuan
country: China
facility: Songyuan Jilin Oilfield Hospital
city: Suqian
country: China
facility: Nanjing Drum Tower Hospital Group
city: Suqian
country: China
facility: Shuyang County Hospital of Traditional Chinese Medicine
city: Suqian
country: China
facility: Sihong First People's Hospital
city: Suqian
country: China
facility: Suqian First People's Hospital
city: Suqian
country: China
facility: Suqian Hospital Affiliated to Nanjing Drum Tower Hospital Group
city: Suqian
country: China
facility: Suqian Zhongwu Hospital
city: Suzhou
country: China
facility: he First Affiliated Hospital of Soochow University
city: Suzhou
country: China
facility: Kunshan First People's Hospital
city: Suzhou
country: China
facility: Kunshan Hospital of Traditional Chinese Medicine
city: Suzhou
country: China
facility: Rudong County People's Hospital
city: Suzhou
country: China
facility: Suzhou Fifth People's Hospital
city: Suzhou
country: China
facility: Suzhou Hospital of Integrated Traditional Chinese and Western Medicine
city: Suzhou
country: China
facility: Suzhou Municipal Hospital
city: Suzhou
country: China
facility: Suzhou Ninth People's Hospital
city: Suzhou
country: China
facility: Taicang First People's Hospital
city: Suzhou
country: China
facility: The Fourth Affiliated Hospital of Soochow University
city: Suzhou
country: China
facility: Xiaoxian People's Hospital
city: Suzhou
country: China
facility: Zhangjiagang First People's Hospital
city: Tai'an
country: China
facility: Tai'an Central Hospital
city: Taihe
country: China
facility: Taihe County People's Hospital
city: Taiyuan
country: China
facility: Shanxi Bethune Hospital
city: Taiyuan
country: China
facility: Shanxi Provincial Hospital of Traditional Chinese Medicine
city: Taiyuan
country: China
facility: Shanxi Provincial People's Hospital
city: Taiyuan
country: China
facility: Taiyuan Central Hospital
city: Taiyuan
country: China
facility: Taiyuan Third People's Hospital
city: Taiyuan
country: China
facility: The First Hospital of Shanxi Medical University
city: Taizhou
country: China
facility: Taixing People's Hospital
city: Taizhou
country: China
facility: Taixing Second People's Hospital
city: Taizhou
country: China
facility: Taizhou People's Hospital
city: Taizhou
country: China
facility: Taizhou Second People's Hospital
city: Taizhou
country: China
facility: Xinghua People's Hospital
city: Taizhou
country: China
facility: Zhejiang Taizhou Hospital
city: Tangshan
country: China
facility: Tangshan Seventh Hospital
city: Tengzhou
country: China
facility: Tengzhou Central People's Hospital
city: Tianjin
country: China
facility: Baodi District People's Hospital
city: Tianjin
country: China
facility: Binhai New Area Dagang Hospital
city: Tianjin
country: China
facility: Tianjin Binhai People's Hospital
city: Tianjin
country: China
facility: Tianjin Fifth Central Hospital
city: Tianjin
country: China
facility: Tianjin Port Hospital
city: Tianjin
country: China
facility: Tianjin Second People's Hospital
city: Tianjin
country: China
facility: Tianjin TEDA Hospital
city: Tianjin
country: China
facility: Tianjin Third Central Hospital
city: Tongjiang
country: China
facility: Tongjiang People's Hospital
city: Tongliao
country: China
facility: Tongliao Sixth People's Hospital
city: Tongling
country: China
facility: Tongling People's Hospital
city: Weifang
country: China
facility: Weifang People's Hospital
city: Weihai
country: China
facility: The 970th Hospital of the Joint Logistics Support Force, PLA
city: Wenzhou
country: China
facility: The First Affiliated Hospital of Wenzhou Medical University
city: Wenzhou
country: China
facility: The Second Affiliated Hospital of Wenzhou Medical University
city: Wenzhou
country: China
facility: Wenzhou Sixth People's Hospital
city: Wu'an
country: China
facility: Wu'an First People's Hospital
city: Wuhai
country: China
facility: Wuhai Fifth People's Hospital
city: Wuhan
country: China
facility: Changjiang Shipping General Hospital (Wuhan Brain Hospital)
city: Wuhan
country: China
facility: Hubei Third People's Hospital (Hubei Zhongshan Hospital)
city: Wuhan
country: China
facility: Jiangxia District First People's Hospital, Wuhan
city: Wuhan
country: China
facility: The Fifth Hospital of Wuhan
city: Wuhan
country: China
facility: Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology
city: Wuhan
country: China
facility: Wuhan Hankou Hospital
city: Wuhan
country: China
facility: Wuhan Jinyintan Hospital
city: Wuhan
country: China
facility: Wuhan Seventh Hospital
city: Wuwei
country: China
facility: Gansu Wuwei Cancer Hospita
city: Wuwei
country: China
facility: Wuwei People's Hospital
city: Wuxi
country: China
facility: Jiangyin People's Hospital
city: Wuxi
country: China
facility: Jiangyin Traditional Chinese Medicine Hepatobiliary Hospital
city: Wuxi
country: China
facility: Taihu Hospital
city: Wuxi
country: China
facility: Wuxi Fifth People's Hospital
city: Wuxi
country: China
facility: Wuxi No. 2 Hospital of Traditional Chinese Medicine
city: Wuxi
country: China
facility: Wuxi No. 5 People's Hospital
city: Wuxi
country: China
facility: Wuxi Second Hospital of Traditional Chinese Medicine
city: Wuxi
country: China
facility: Yixing People's Hospital
city: Wuzhou
country: China
facility: The Third People's Hospital of Wuzhou
city: Xi'an
country: China
facility: The First Affiliated Hospital of Xi'an Jiaotong University
city: Xi'an
country: China
facility: The Second Affiliated Hospital of Air Force Medical University
city: Xi'an
country: China
facility: The Second Affiliated Hospital of Xi'an Jiaotong University
city: Xiamen
country: China
facility: The 909th Hospital of the Joint Logistics Support Force
city: Xiamen
country: China
facility: The First Affiliated Hospital of Xiamen University
city: Xiamen
country: China
facility: Xiamen Hospital of Traditional Chinese Medicine
city: Xiamen
country: China
facility: Zhongshan Hospital Xiamen, Fudan University
city: Xiaogan
country: China
facility: Xiaogan Central Hospital
city: Xiaogan
country: China
facility: Yunmeng County People's Hospital
city: Xingtai
country: China
facility: Qinghe County People's Hospital
city: Xingtai
country: China
facility: Xingtai Fifth Hospital
city: Xingtai
country: China
facility: Xingtai Ninth Hospital
city: Xingtai
country: China
facility: Xingtai People's Hospital
city: Xining
country: China
facility: Datong Hui and Tu Autonomous County People's Hospital
city: Xining
country: China
facility: Qinghai Fourth People's Hospital
city: Xining
country: China
facility: Qinghai Provincial People's Hospital
city: Xining
country: China
facility: Qinghai Red Cross Hospital
city: Xinjiang
country: China
facility: Ili Kazakh Autonomous Prefecture Kuitun Hospital
city: Xinjiang
country: China
facility: Xinjiang Production and Construction Corps 6th Division Hospital
city: Xintai
country: China
facility: Xintai People's Hospital
city: Xiushui
country: China
facility: Xiushui County First People's Hospital
city: Xizang
country: China
facility: People's Hospital of Tibet Autonomous Region
city: Xizang
country: China
facility: Shannan People's Hospital
city: Xizang
country: China
facility: Third People's Hospital of Tibet Autonomous Region
city: Xuancheng
country: China
facility: Jixi County People's Hospital
city: Xuancheng
country: China
facility: Xuancheng Central Hospital
city: Xuancheng
country: China
facility: Xuancheng People's Hospital
city: Xuzhou
country: China
facility: Affiliated Hospital of Xuzhou Medical University
city: Xuzhou
country: China
facility: Feng County People's Hospital
city: Xuzhou
country: China
facility: Pei County People's Hospital
city: Xuzhou
country: China
facility: Pizhou People's Hospital
city: Xuzhou
country: China
facility: Xuzhou Central Hospital
city: Xuzhou
country: China
facility: Xuzhou Infectious Disease Hospital
city: Xuzhou
country: China
facility: Xuzhou Mining Group Traditional Chinese Medicine Hospital
city: Xuzhou
country: China
facility: Xuzhou New Health Hospital
city: Yanan
country: China
facility: Yan'an Hospital of Traditional Chinese Medicine
city: Yanan
country: China
facility: Yan'an People's Hospital
city: Yanbian
country: China
facility: Affiliated Hospital of Yanbian University
city: Yanbian
country: China
facility: Dunhua City Hospital
city: Yanbian
country: China
facility: Wangqing County People's Hospital
city: Yancheng
country: China
facility: Funing County People's Hospital
city: Yancheng
country: China
facility: Jianhu County People's Hospital
city: Yancheng
country: China
facility: Xuyi County People's Hospital
city: Yancheng
country: China
facility: Yancheng First People's Hospital
city: Yancheng
country: China
facility: Yancheng Seventh People's Hospital
city: Yangquan
country: China
facility: Yangquan Coal Mining Group General Hospital
city: Yangquan
country: China
facility: Yangquan Third People's Hospital
city: Yangzhou
country: China
facility: Jiangdu District Third People's Hospital
city: Yangzhou
country: China
facility: Northern Jiangsu People's Hospital
city: Yangzhou
country: China
facility: Yangzhou Third People's Hospital
city: Yantai
country: China
facility: Binzhou Medical University Yantai Affiliated Hospital
city: Yantai
country: China
facility: Yantai Qishan Hospital
city: Yibin
country: China
facility: Yibin First People's Hospital
city: Yichang
country: China
facility: Dangyang People's Hospital
city: Yichang
country: China
facility: Yichang Central People's Hospital
city: Yichang
country: China
facility: Yichang Third People's Hospital
city: Yichang
country: China
facility: Zhijiang People's Hospital
city: Yichun
country: China
facility: Yichun People's Hospital
city: Yinchuan
country: China
facility: Ningxia Medical University General Hospital
city: Yingkou
country: China
facility: Yingkou Third People's Hospital
city: Yingtan
country: China
facility: Yingtan People's Hospital
city: Yining
country: China
facility: Ili Kazakh Autonomous Prefecture Traditional Chinese Medicine
city: Yining
country: China
facility: Yining City People's Hospital
city: Yulin
country: China
facility: Jingbian County People's Hospital
city: Yulin
country: China
facility: The First People's Hospital of Yulin
city: Yulin
country: China
facility: The Second People's Hospital of Yulin
city: Yulin
country: China
facility: Yulin First Hospital
city: Yulin
country: China
facility: Yulin Hospital of Traditional Chinese Medicine
city: Yuncheng
country: China
facility: Jishan County People's Hospital
city: Yuncheng
country: China
facility: Linyi County People's Hospital
city: Yuncheng
country: China
facility: Xia County People's Hospital
city: Yuncheng
country: China
facility: Yanhu District People's Hospital, Yuncheng City
city: Yuncheng
country: China
facility: Yongji People's Hospital
city: Yuncheng
country: China
facility: Yuncheng Hospital of Traditional Chinese Medicine
city: Yuncheng
country: China
facility: Yuncheng Second Hospital
city: Zaozhuang
country: China
facility: Shandong Health Group Zaozhuang Central Hospital
city: Zhangjiakou
country: China
facility: Zhangjiakou Infectious Disease Hospital
city: Zhanjiang
country: China
facility: Affiliated Hospital of Guangdong Medical University
city: Zhenjiang
country: China
facility: Jurong People's Hospital
city: Zhenjiang
country: China
facility: Yangzhong Hospital of Traditional Chinese Medicine
city: Zhenjiang
country: China
facility: Yangzhong People's Hospital
city: Zhenjiang
country: China
facility: Zhenjiang Third People's Hospital
city: Zhongshan
country: China
facility: The Second People's Hospital of Zhongshan
city: Zhongshan
country: China
facility: Zhongshan Hospital of Traditional Chinese Medicine
city: Zibo
country: China
facility: Zibo City No.148 Hospital
city: Zibo
country: China
facility: Zibo Hospital of Traditional Chinese Medicine
city: Zibo
country: China
facility: Zibo Infectious Diseases Hospital
city: Zigong
country: China
facility: Zigong First People's Hospital
city: Ürümqi
country: China
facility: The Fifth Affiliated Hospital of Xinjiang Medical University
city: Ürümqi
country: China
facility: The First Affiliated Hospital of Xinjiang Medical University
city: Ürümqi
country: China
facility: Xinjiang Uyghur Autonomous Region Traditional Chinese Medicine Hospital
Study officials:
affiliation: Peking University First Hospital
name: Guiqiang Wang, Ph.D
role: PRINCIPAL_INVESTIGATOR
References: