Clinical trial NCT02617017: Buspirone Treatment of Iatrogenic Dyskinesias in Advanced Parkinson' Disease
Official title: Buspirone Treatment of Iatrogenic Dyskinesias in Advanced Parkinson' Disease. Multicenter, International, Placebo-controlled, Randomised, Double Blind Trial
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE3
Conditions: Parkinson
Keywords: Parkinson disease
Levodopa induce dyskinesia
Lead sponsor: Assistance Publique - Hôpitaux de Paris
Sponsor class: OTHER
First posted: 2015-11-30
Enrollment: 99
Sex: ALL
Minimum age (years): 35
Maximum age (years): 80
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: Parkinson's disease (PD) is one of the most common neurodegenerative diseases, with a higher prevalence in the elderly. Levodopa induced dyskinesias (LID) are a major motor complications that impair quality of life for patients with PD. The mechanisms of these dyskinesias remain unclear, but several hypotheses have been put forward: non continuous, pulsatile stimulation of dopaminergic receptors, or alterations of other neurotransmitters within the motor striatum such as glutamate and serotonin.

Few strategies are now available to treat severe LID:

* Medications: reduction of dopaminergic treatment, addition of amantadine,
* Functional neurosurgery. The purpose of this study is to investigate the efficacy of buspirone in PD patients suffering from dyskinesias. The role of serotonin in the occurrence of LID was recently demonstrated in transplant PD patients and a test double-blind, single dose was achieved. Following administration of 10 mg oral buspirone, a 5HT1A agonist, LID were clearly improved. A antidyskinetic effect of buspirone had already been reported in 1991 and 1994, but identification of buspirone as a serotonin receptor agonist has been reported more recently.

This trial is aimed at (1) validate the serotoninergic hypothesis of hyperkinetic levodopa induced dyskinesias (LID) in Pakinson's disease patients, (2) evaluate, in a phase 3 trial, the motor efficacy of buspirone to improve LID vs placebo, (3) look at a possible dose/effect relationship and (4) check the hypothesis of a better therapeutic ratio using the association of buspirone and amantadine instead than a single drug.


Eligibility criteria: Inclusion Criteria

* The subject is an out-patient between 35 year and 80 years of age
* Diagnosis of idiopathic Parkinson's disease according to the UK Parkinson's Disease Society Brain Bank Clinical Diagnosis Criteria
* Dyskinesias are present more than 25% of the waking day according to item 4-1 of MDS-UPDRS
* Dyskinesias are at least moderately disabling item 4-2 of MDS-UPDRS replaced by Dyskinesias are at least slightly disabling item 4-2 of MDS-UPDRS (amendment n°2)
* The subject is able to identify dyskinesia, ON and OFF, and apply to his/her own state
* Stable dose of anti-Parkinsonian drugs for at least 4 weeks up to the screening
* The subject is considered as being optimally treated at the time of inclusion
* Written and signed informed consent to participate in the study
* Maximal Hoehn and Yahr staging : III in "ON" phases, IV in "OFF"
* Active affiliation to social security
* Menopausal or under contraception for woman

Exclusion Criteria

* Female subjects : pregnant or lactating
* Atypical parkinsonian syndrome
* Weight less than 40 Kgs
* Mini-Mental State Examination (MMSE) less than 24
* The subject is participating in another clinical study within the past 12 weeks
* Planned participation in another therapeutic clinical study
* Previous treatment with buspirone, less than 6 months before Week 0
* Known allergy to buspirone
* Known lactose intolerance
* Clinically significant illness that might interfere with the study
* Dementia or other psychiatric illness
* Drug or alcohol abuse replaced by Substance use disorder (alcohol i.e. \> 3 drinks per day for men and \> 2 drinks per day for women,drug, medicinal product) (amendment n°1)
* Legal incapacity or limited legal capacity
* Deep brain stimulation performed less than 12 months before protocol initiation, or unstable parameters of stimulation 4 weeks before week 0
* Severe renal and / or hepatic impairment
* History of seizures or epilepsy

Primary outcomes:
measure: Between-group comparison of changes in UDysRS scores
timeFrame: Between baseline and week 12
Secondary outcomes:
measure: Comparison, in both groups of patients of Unified Parkinson's Disease Rating Scale (MDS-UPDRS) part 3-4 (efficacy)
timeFrame: At week 0,Week2, Week4, Week12, Week13
measure: Comparison, in both groups of patients of MDS-UPDRS part 1-2 (quality of life)
timeFrame: At week Week-2, Week0, Week2, Week4, Week12, Week13
measure: Comparison, in both groups of patients of PDQ-39 (quality of life)
timeFrame: At week 0 and week 12
measure: Comparison, in both groups of patients of side effects (tolerance)
timeFrame: At week Week-2, Week0, Week2, Week4, Week12, Week13
measure: Maximum dose accepted by patients (tolerance)
timeFrame: At week Week-2, Week0, Week2, Week4, Week12, Week13
Other outcomes:
Locations:
city: Creteil
country: France
facility: Henri Mondor Hospital
Study officials:
affiliation: Assistance Publique - Hôpitaux de Paris
name: Philippe Rémy, PhD
role: PRINCIPAL_INVESTIGATOR
References:
citation: McFarthing K, Prakash N, Simuni T. CLINICAL TRIAL HIGHLIGHTS - DYSKINESIA. J Parkinsons Dis. 2019;9(3):449-465. doi: 10.3233/JPD-199002. No abstract available.