louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT00793052: Etodalac, Etoricoxib and Dexamethasone for Prevention of Pain ,Swelling and Trismus Following Third Molar Surgery
Official title: Etodalac, Etoricoxib and Dexamethasone for Prevention of Pain ,Swelling and Trismus Following Third Molar Surgery: A Prospective, Double-Blind Study
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Trismus
Edema
Pain
Keywords: trismus
Edema
pain
Lead sponsor: Tel-Aviv Sourasky Medical Center
Sponsor class: OTHER_GOV
First posted: 2008-11-19
Enrollment: 80
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: TREATMENT

Brief summary: The purpose of this study is to determine whether Etodalac, Etoricoxib and Dexamethasone are effective for Prevention of Pain ,Swelling and Trismus Following Third Molar Surgery


Eligibility criteria: Inclusion Criteria:

* Patients who are refered for third molar extraction to our center
* Must be able to swallow tablets

Exclusion Criteria:

* Diabetes mellitus
* Thyroid diseases
* Cardiovascular diseases
* renal diseases
* hepatic diseases
* respiratory system diseases
* adrenal diseases
* Allergy to Etodalac, Etoricoxib or Dexamethasone
* Gastric ulcers
* psychiatric diseases
* Pregnant or breast feeding womans

Primary outcomes:
measure: PAIN- By VAS graded from 1-10 TRISMUS- By MAX mouth opening from the first incisors adages POST OPERATIVE SWELLing - By measurement the distance between the Right and LEFT ear's tragus
timeFrame: 1 week
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
affiliation: MAXILLOFACIAL SURGERY - TASMC
name: benjamin Shlomi, DMD
role: STUDY_CHAIR
References:
Clinical trial NCT05428059: The Effect of Mobile Health-Education Application on Healthy Lifestyle Behaviors in Patients Planned for Bariatric Surgery
Official title: The Effect of Mobile Health-Education Application on Healthy Lifestyle Behaviors in Patients Planned for Bariatric Surgery:A Randomized Controlled Study
Study type: INTERVENTIONAL
Overall status: SUSPENDED
Phase: NA
Conditions: Nursing Caries
Bariatric Surgery Candidate
Mobile Education
Lead sponsor: Cukurova University
Sponsor class: OTHER
First posted: 2022-06-22
Enrollment: 50
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: CROSSOVER
Primary purpose: SUPPORTIVE_CARE

Brief summary: Obesity, which is the second leading cause of preventable death in the world, affects all the systems in the body and affects many physiological problems, as well as the mental state, body image and quality of life of the individual. For this reason, obese individuals try various treatment methods in order to get rid of obesity, and in cases where these methods fail, they often prefer bariatric surgery. It is very important that patients who will undergo bariatric surgery can adapt to the anatomical changes in their body and shape their lifestyle accordingly. Otherwise, it is inevitable for patients to face various complications after surgery. After bariatric surgery, a structured training program in the preoperative period is of great importance in order for the patient to adapt to the changes in his body, to prevent the development of possible complications, to be affected by the negativities that may occur due to the current change, and to prepare for the new lifestyle. In this context, the main subject of this research is to enable individuals to gain healthy lifestyle behaviors by providing mobile-based training and consultancy services that enable them to easily access the right information at the desired time and place.


Eligibility criteria: Inclusion Criteria:

* Being literate,
* Being able to understand, speak Turkish and not have a hearing impairment,
* First time to undergo bariatric surgery,
* Absence of any psychiatric disorder that will reduce the ability to comprehend and understand,
* Ability to use Android-based smartphones,
* Agreeing to participate in the research.

Exclusion Criteria:

* Patient's desire to quit the study

Primary outcomes:
measure: The Effect of Mobile Health-Education Application on Healthy Lifestyle Behaviors in Patients Planned for Bariatric Surgery
timeFrame: one months
Secondary outcomes:
Other outcomes:
Locations:
city: Adana
country: Turkey
facility: Çukurova University Institute of Health Sciences
Study officials:
References:
Clinical trial NCT05567900: Health Care Seeking Behavior and Knowledge Assessment of Hungarian Women About Pelvic Floor Disorders
Official title: Hungarian Women's Health Care Seeking Behavior and Knowledge of Urinary Incontinence and Pelvic Organ Prolapse
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Urinary Incontinence
Pelvic Organ Prolapse
Knowledge, Attitudes, Practice
Behavior, Health
Lead sponsor: University of Pecs
Sponsor class: OTHER
First posted: 2022-10-05
Enrollment: 596
Sex: FEMALE
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: ECOLOGIC_OR_COMMUNITY
Time perspective: CROSS_SECTIONAL
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Women aged 18 years or older who are able to read and write Hungarian.

Brief summary: The aim of this study is to assess women's health care seeking behavior and knowledge of urinary incontinence and pelvic organ prolapse and to culturally adapt the Prolapse and Incontinence Knowledge Questionnaire (PIKQ) for the Hungarian population.


Eligibility criteria: Inclusion Criteria:

* Woman
* Age 18 and above
* Ability to read and write Hungarian
* Willing to complete the online survey
* Providing consent to participate

Exclusion Criteria:

* Respondents who had already completed the questionnaire on a prior occasion
* Respondents who unable to complete the online survey due to illiteracy

Primary outcomes:
measure: Urinary incontinence and pelvic organ prolapse knowledge
timeFrame: Baseline
measure: Health seeking behavior
timeFrame: Baseline
Secondary outcomes:
measure: Urinary incontinence
timeFrame: Baseline
measure: Practice of pelvic floor muscle training (PFMT)
timeFrame: Baseline
Other outcomes:
Locations:
city: Pécs
country: Hungary
facility: University of Pécs
state: Baranya
Study officials:
affiliation: University of Pecs
name: Márta Hock, Habilitation
role: STUDY_DIRECTOR
References:
Clinical trial NCT06867900: Unexplained Recurrent Pregnancy Loss: New Therapeutic Perspectives
Official title: Unexplained Recurrent Pregnancy Loss: New Therapeutic Perspectives
Study type: INTERVENTIONAL
Overall status: ACTIVE_NOT_RECRUITING
Phase: NA
Conditions: Miscarriage, Recurrent
Keywords: Recurrent pregnancy loss
Lead sponsor: Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Sponsor class: OTHER
First posted: 2025-03-10
Enrollment: 22
Sex: FEMALE
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: PREVENTION

Brief summary: Evaluation of gut permeability and endometrial inflammasome NLRP3 in women with unexplaid recurrent pregnancy loss before-after administration of Bifidobacteriumlongum ES1.


Eligibility criteria: Inclusion Criteria:

* Idiopathic recurrent pregnancy loss
* Genetic predisposition to celiac disease

Exclusion Criteria:

-

Primary outcomes:
measure: Assessment of Endometrial inflammation in RPL women
timeFrame: 3 months
measure: Assessment of Gut permeability status in RPL women
timeFrame: 3 months
Secondary outcomes:
Other outcomes:
Locations:
city: Rome
country: Italy
facility: Reasearch Laboratory 3J IRCCS Gemelli
Study officials:
affiliation: Fondazione Policlinico Universitario Agostino Gemelli IRCCS
name: Chiara Tersigni
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT02957500: To Evaluate Anti-adhesive Effect and Safety of a Mixed Solid of Poloxamer, Gelatin and Chitosan(Mediclore®)
Official title: To Evaluate Anti-adhesive Effect and Safety of a Mixed Solid of Poloxamer, Gelatin and Chitosan(Mediclore®) After Intrauterine Surgery in Patient With Gynecological Disease, a Multicenter, Randomized, Double- Blinded Study
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Gynecologic Disease
Lead sponsor: CGBio Inc.
Sponsor class: INDUSTRY
First posted: 2016-11-06
Enrollment: 198
Sex: FEMALE
Minimum age (years): 19
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: PREVENTION

Brief summary: The purpose of this study is to evaluate the efficacy and safety of Mediclore®, as an antiadhesive barrier, which is made of Poloxamer, Gelatin and Chitosan.

Detailed description: to evaluate the efficacy and safety of Mediclore®, as an antiadhesive barrier

Eligibility criteria: Inclusion Criteria:

* the patients with submucosal myomas, endometrial polyps, intra-uterine adhesion, uterine septa, dysfunctional uterine bleeding
* Written informed consent
* Patients without clinically significant lab

Exclusion Criteria:

* having enrolled another clinical trials within 1 month
* Immunosuppression or autoimmune disease
* Anticoagulant, general steroids within a week from surgery
* Incompatible medications
* Serious diseases (heart failure, renal failure, liver failure, uncontrolled hypertension, diabetes mellitus, coagulation deficiencies)

Primary outcomes:
measure: Adhesion incidence rate following 4 weeks
timeFrame: 4weeks
Secondary outcomes:
Other outcomes:
Locations:
city: Seoul City
country: Korea, Republic of
facility: CHA kangnam medical center, CHA university
Study officials:
References:
Clinical trial NCT01001000: Colour Coded Duplex Ultrasound of Native Arterio-venous Fistula for Haemodialysis With Venous Pressure Measurement Using Controlled Compression Ultrasound as a Predictor for Shunt Maturation in the Early Postoperative Phase
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Renal Insufficiency
Lead sponsor: University of Zurich
Sponsor class: OTHER
First posted: 2009-10-23
Enrollment: 40
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Patients after creation of a native arterio-venous fistula at the cephalic vein for hemodialysis access

Brief summary: Prospective observational ultrasound study of native arterio-venous fistula for haemodialysis with venous pressure measurement using controlled compression ultrasound.


Eligibility criteria: Inclusion criteria:

* Patients after creation of a native arterio-venous fistula at the cephalic vein for hemodialysis access;
* Informed consent.

Exclusion criteria:

* Former creation of a native arterio-venous fistula at the same arm;
* Known upper extremity occlusive arterial disease;
* Situation when ultrasound examination is not suitable: extreme swelling of the arm, post-operative pain, hematoma, local infections.

Primary outcomes:
Secondary outcomes:
Other outcomes:
Locations:
city: Zurich
country: Switzerland
Study officials:
affiliation: UniversitaetsSpital Zuerich
name: 01 Studienregister MasterAdmins
role: STUDY_DIRECTOR
References:
Clinical trial NCT06180200: Study of the in Vivo Expression of MU Opioid Receptors Using PET and the Selective Tracer [C-11] Carfentanil in Normal Weight and Obese Subjects
Official title: Study of the in Vivo Expression of MU Opioid Receptors Using PET and the Selective Tracer [C-11] Carfentanil in Normal Weight and Obese Subjects
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Nuclear Medicine
Lead sponsor: IRCCS San Raffaele
Sponsor class: OTHER
First posted: 2023-12-22
Enrollment: 16
Sex: MALE
Minimum age (years): 18
Maximum age (years): 40
Standard ages: ADULT
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: For the study, 10 normal male subjects and 10 obese subjects not affected by mental or physical pathological alterations will be recruited.

Brief summary: Positron emission tomography (PET) is a nuclear medicine technique that allows the measurement, in vivo in humans, with a non-invasive method, of the regional distribution of substances marked with positron emission isotopes such as C-11, in different districts bodily. Using this method it is therefore possible to directly measure at the level of the brain the distribution of receptors, enzymes, reuptake sites, as well as their interaction with various classes of drugs and the related modifications that may be present during the pathology.

The evaluation of the endogenous opiate receptor system will be implemented by comparing the in vivo binding maps of 11C carfentanil in the two groups of subjects under examination (normal weight, NOR and obese, OB, based on body mass index, BMI); in fact, experimental data deriving from previous studies support the hypothesis that the basis of obesity and incorrect eating behaviors is a dysregulation of the endogenous ligand-mu opioid receptor interaction. The comparison of the data deriving from the analysis of the PET exams performed on the two groups of subjects will therefore allow us to evaluate the alterations of the opioid system possibly present in obese subjects.


Eligibility criteria: Inclusion Criteria:

* aged between 18 and 40 years;
* structured sports activity \< 2 hours per week

Exclusion Criteria:

* drug allergy;
* clinical evidence of neuropsychiatric pathologies.

Primary outcomes:
measure: PET with 11C CARFENTANIL for the analysis of the expression of mu opioid receptors.
timeFrame: 3 years
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
References:
Clinical trial NCT06994000: Caregiver Stress, Mental Health, and Self-Efficacy in ADHD Households
Official title: Caring Under Pressure: The Relationship of Caregivers' Stress, Mental Health, and Self-Efficacy in ADHD Households
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: ADHD
Keywords: Stress
Mental Health
Self-Efficacy
Lead sponsor: Alexandria University
Sponsor class: OTHER
First posted: 2025-05-29
Enrollment: 160
Sex: ALL
Minimum age (years): 18
Maximum age (years): 60
Standard ages: ADULT
Accepts healthy volunteers: no
Observational model: OTHER
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: A convenience sample of 160 participants included caregivers of children diagnosed with ADHD

Brief summary: Investigate the relationship between caregiver stress, mental health, and self-efficacy in families with children who have ADHD.

Detailed description: A cross-sectional design was utilized, involving 160 caregivers from the Abdullah Al-Tamimi Autism Center in Unaizah, Saudi Arabia. Participants completed an online questionnaire that assessed sociodemographic information, caregiver stress (via the Kingston Caregiver Stress Scale), mental health (using the Mental Health Continuum-Short Form), and self-efficacy (measured by the General Self-Efficacy Scale).

Eligibility criteria: Inclusion Criteria:

mothers, fathers, or grandparents who are involved in the child's primary care and are between the ages of 18 and 60

Exclusion Criteria:

Caregivers who declined to participate in the current study, those who failed to complete the questionnaire, individuals not residing in the same household, and those not engaged in direct patient care

Primary outcomes:
measure: Caregiver Stress
timeFrame: 3 months
measure: Mental Health Continuum
timeFrame: 3 months
measure: General Self-Efficacy
timeFrame: 3 months
Secondary outcomes:
Other outcomes:
Locations:
city: Al Qassim
country: Saudi Arabia
facility: Qassim University
state: Qassim
Study officials:
References:
Clinical trial NCT05526300: Intelligent Hypertension Intervention Study
Official title: Randomized Study of Antihypertensive Intervention by Intelligent Hypertension Management System
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: To Explore Whether the Application of Intelligent Hypertension Management System Can Effectively Reduce Blood Pressure in Hypertensive Patients
Lead sponsor: Shanghai Tong Ren Hospital
Sponsor class: OTHER
First posted: 2022-09-02
Enrollment: 320
Sex: ALL
Minimum age (years): 18
Maximum age (years): 75
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: SINGLE_GROUP
Primary purpose: TREATMENT

Brief summary: To explore whether the application of intelligent hypertension management system can effectively reduce blood pressure in hypertensive patients. A total of 320 eligible subjects will be recruited and randomization to two groups. The standard care group (n=160) will receive conventional hypertension treatment with baseline data collected.Wearable blood pressure monitoring device management group (intervention group, n=160) will receive blood pressure monitoring remotely everyday and antihypertension medication treatment. Primary outcome is Net change in systolic blood pressure from baseline to 3 months follow-up. Secondary outcomes include Net change in diastolic blood pressure hypertension control ratio (BP \< 140/90 mmHg)


Eligibility criteria: Inclusion Criteria:

1. Aged more than 18 years old, less than or equal to 75 years old.
2. Hypertensive patients (systolic/diastolic blood pressure ≥140/90 mmHg at two separate screening/baseline visits)
3. Patients or guardians can skillfully use devices such as smartphones and electronic sphygmomanometers
4. Voluntarily joined and signed the informed consent

Exclusion Criteria:

1. Pregnant women or women planning to become pregnant within the next year;
2. Patients with secondary hypertension
3. Patients with life expectancy less than 1 year
4. Severe hepatic and renal insufficiency (ALT \> 5 times ULA, eGFR \< 15ml/min/1.73mm2)
5. Known active malignancy disease
6. The researcher believes that patients who are not suitable to participate in this study

Primary outcomes:
measure: Net change in systolic blood pressure from baseline to 3 months follow-up
timeFrame: one and three months after study
Secondary outcomes:
measure: Net change in diastolic blood pressure
timeFrame: one and three months after study
measure: Hypertension control ratio (BP < 140/90 mmHg)
timeFrame: one and three months after study
Other outcomes:
Locations:
city: Shanghai
country: China
facility: Shanghai tongren hospital
state: Shanghai
city: Shanghai
country: China
facility: Shanghai Fifth Rehabilitation Hospital
city: Shanghai
country: China
facility: Songjiang hospital, Shanghai jiaotong University, School of medicine
Study officials:
References:
Clinical trial NCT00709800: Pandemic Influenza Plasmid DNA Vaccines (Needle)
Official title: A Phase 1, Double-Blinded Study to Evaluate the Safety, Tolerability, and Immunogenicity of Pandemic Influenza Plasmid DNA Vaccines
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE1
Conditions: Influenza
Keywords: Pandemic Influenza
Avian Influenza
DNA Vaccines
Antibody
T Cells
HA/NP/M2
Lead sponsor: Vical
Sponsor class: INDUSTRY
First posted: 2008-07-03
Enrollment: 56
Sex: ALL
Minimum age (years): 18
Maximum age (years): 45
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: PREVENTION

Brief summary: The trial will enroll up to 57 subjects. Qualified normal healthy volunteers will be enrolled in the study to receive the vaccine or placebo vaccine. Subjects will receive 2 vaccinations with a needle and will be followed for 6 months to evaluate the safety of and the immune system's response to the vaccine. The safety and immune system response will be studied throughout the trial.


Eligibility criteria: Inclusion Criteria:

* 18 to 45 years of age
* Able to provide informed consent and be followed for 6 months

Exclusion Criteria:

* No immunomodulatory therapy within the past 6 months
* No evidence of immunodeficiency or pregnancy
* No laboratory or evidence of clinically significant medical disease
* No history of previous pDNA immunization
* No influenza immunization within the past 30 days
* No blood donations within 30 days of screening visit
* No history of bleeding disorder
* No use of aspirin and/or anticoagulants within 2 weeks of the administration of the investigational vaccines

Primary outcomes:
measure: Safety and Tolerability of VCL-IPT1 and VCL-IPM1 in adult subjects
timeFrame: 6 months
Secondary outcomes:
measure: Influenza-specific immunogenicity of VCL-IPT1 and VCL-IPM1
timeFrame: 6 months
Other outcomes:
Locations:
city: San Diego
country: United States
facility: Accelovance
state: California
city: Baltimore
country: United States
facility: SNBL
state: Maryland
city: Stony Brook
country: United States
facility: SUNY at Stonybrook, Stony Brook Medical Center
state: New York
Study officials:
affiliation: Vical
name: Don Guterwill, BS, MT
role: STUDY_CHAIR
References:
Clinical trial NCT02143700: Cognitive Status in Chronic Obstructive Pulmonary Disease's Patients
Official title: Clinical Profile and Cognitive Status in Chronic Obstructive Pulmonary Disease's Patients
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Chronic Obstructive Pulmonary Disease
Keywords: exacerbation
cognitive
chronic obstructive pulmonary disease
Lead sponsor: Universidad de Granada
Sponsor class: OTHER
First posted: 2014-05-21
Enrollment: 60
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: CASE_CROSSOVER
Time perspective: CROSS_SECTIONAL
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Patients diagnosed of chronic obstructive pulmonary disease.

Brief summary: Chronic obstructive pulmonary disease (COPD) is a chronic condition involving an impairment in functionality and in the execution of activities of daily life. The hypothesis of this study is to examine the relationship between cognitive status and clinical profile (respiratory, sleep quality, nutritional status) in patients with chronic obstructive pulmonary disease in two different moments: exacerbation or stable situation.

Detailed description: Chronic obstructive pulmonary disease is a pathology with a systemic impact with a progressive evolution that is characterized by the presence of chronic airflow obstruction.

Patients with COPD may have problems with cognitive functioning, either globally or in single cognitive domains, such as information processing, attention and concentration, memory, executive functioning and self-regulation.

Several studies have determined the prevalence of cognitive impairment in COPD compared to healthy control subjects, reaching very high levels, 36% of COPD patients with mild cognitive impairment compared with 12 % non- COPD subjects.

Eligibility criteria: Inclusion Criteria:

* Clinical diagnosis of chronic obstructive pulmonary disease with exacerbation or stable.
* Signed written consent.
* Medical approval for inclusion

Exclusion Criteria:

* Heart disease.
* Neurological patients.
* Severe cognitive impairment in order not to complete the assessment.

Primary outcomes:
measure: Cognitive impairment
timeFrame: Baseline
Secondary outcomes:
measure: Sleep quality
timeFrame: Baseline
measure: Activity monitoring
timeFrame: Baseline
measure: Nutritional state
timeFrame: Baseline
measure: Quality of life
timeFrame: Baseline
measure: Cough
timeFrame: Baseline
measure: Comorbidities
timeFrame: Baseline
measure: Anxiety and depression
timeFrame: Baseline
measure: Cognitive flexibility
timeFrame: Baseline
measure: Forced vital capacity
timeFrame: Baseline
measure: Forced expiratory volume in the first second
timeFrame: Baseline
Other outcomes:
Locations:
city: Granada
country: Spain
facility: Department of Physical Therapy
Study officials:
References: