louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT01749917: Exercise Intervention and Dexterity in Parkinson
Official title: Therapeutic Intervention in Motor Disorders in Parkinson.
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Parkinson
Keywords: Parkinson.
Dexterity.
Balance.
Exercises.
Lead sponsor: Universidad de Granada
Sponsor class: OTHER
First posted: 2012-12-17
Enrollment: 60
Sex: ALL
Minimum age (years): 40
Maximum age (years): 65
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NON_RANDOMIZED
Intervention model: SINGLE_GROUP
Primary purpose: TREATMENT

Brief summary: The investigators conducted an intervention based in proprioceptive exercises and balance tasks. The investigators also carried out a brief intervention in manual dexterity.

The study hypothesis is that a brief intervention in upper extremities and a exercise program can increase functionality in Parkinson.

Detailed description: Motor symptoms in Parkinson frequently affect upper extremities. This has been associated in previous studies with limitation in the performance of activities of daily living and, consequently, with a decrease in quality of life. The possibility that a brief intervention improves eye-hand dexterity in Parkinson's, may be a therapeutic option to improve the performance of activities of daily living. The investigators also conducted an intervention based in proprioceptive exercises and balance tasks to improve functionality.

Eligibility criteria: Inclusion Criteria:

* Subjects diagnosed with Parkinson attending to the Parkinson Association of Granada.
* Subjects who can complete the assessment battery of tests at the beginning and at the end of the study.

Exclusion Criteria:

* Auditive and visual disturbances.
* Cognitive problems.
* Psychiatric pathology.
* Sensorial disturbances.
* Traumatic pathology of the hand.
* Concomitant neurological conditions.

Primary outcomes:
measure: Manual dexterity
timeFrame: baseline, 6 months
Secondary outcomes:
measure: Grip strength
timeFrame: baseline, 6 months
measure: Pressure pain measure
timeFrame: baseline, 6 months.
measure: Nervous assessment
timeFrame: baseline, 6 months.
measure: Risk of falls.
timeFrame: baseline, 6 months.
Other outcomes:
Locations:
city: Granada
country: Spain
facility: Faculty of Health Sciences. University of Granada.
state: Andalucia
Study officials:
affiliation: Department of Physical Therapy. University of Granada.
name: M. Carmen Valenza, PH MD
role: PRINCIPAL_INVESTIGATOR
References:
citation: Mateos-Toset S, Cabrera-Martos I, Torres-Sanchez I, Ortiz-Rubio A, Gonzalez-Jimenez E, Valenza MC. Effects of a Single Hand-Exercise Session on Manual Dexterity and Strength in Persons with Parkinson Disease: A Randomized Controlled Trial. PM R. 2016 Feb;8(2):115-22. doi: 10.1016/j.pmrj.2015.06.004. Epub 2015 Jun 14.
Clinical trial NCT02711917: Rocuronium Consumption in Etomidate-based and Propofol-based General Anesthesia Under Sevoflurane
Official title: Consumption of Rocuronium Under Etomidate-based Versus Propofol-based Maintenance of General Anesthesia Under Different Concentration of Sevoflurane- BIS Guided Clinical Trial in a Closed Loop Infusion System
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Neuromuscular Monitoring
Keywords: Propofol
Sevoflurane
Etomidate
Rocuronium
BIS
Closed loop infusion system
Lead sponsor: Tianjin Medical University General Hospital
Sponsor class: OTHER
First posted: 2016-03-17
Enrollment: 175
Sex: ALL
Minimum age (years): 40
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL

Brief summary: Different concentration of sevoflurane was given to maintain anesthesia. The dose of propofol to maintain BIS between 40-60 and the consumption of rocuronium was recorded and evaluated.

Detailed description: 2 age group of patients was selected, 40-60 years and above 60 years. Maintenance of anesthesia was carried out using different concentration of Sevoflurane, ie MAC 0.5, 0.75 and 1.0. Bis value was kept between 40-60 and the dose of propofol required was recorded. Rocuronium infusion given in a close loop infusion system for different group was tabulated. The results was then analysed.

Eligibility criteria: Inclusion Criteria:

* BMI \< 30
* elective Gynaecological/abdominal/urological surgery
* Operation time \< 3hrs
* ASA I/II
* Intubated patients

Exclusion Criteria:

* Coronary artery disease, cardiac, lung, hepatic and renal insufficiency
* Severe uncontrolled HBP
* Obesity (BMI \>30)
* Neuromuscular and metabolic diseases
* Receiving medication known to influence neuromuscular transmission
* Pregnancy
* Psychiatric disorders
* Allergy history to any of the drugs that will be used

Primary outcomes:
measure: consumption of propofol
timeFrame: Intraoperative
Secondary outcomes:
measure: Recovery Index
timeFrame: Intraoperative
measure: Onset time
timeFrame: Intraoperative
measure: Sevoflurane time
timeFrame: Intraoperative
Other outcomes:
Locations:
Study officials:
affiliation: Head of department anesthesiology
name: Guolin Wang, Professor
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT05506917: Perio Treatment & Cerebrovascular Function
Official title: Impact of Periodontal Treatment on Brain Hemodynamics
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Periodontitis
Lead sponsor: University of Santiago de Compostela
Sponsor class: OTHER
First posted: 2022-08-18
Enrollment: 30
Sex: ALL
Minimum age (years): 18
Maximum age (years): 80
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: NA
Intervention model: SINGLE_GROUP
Intervention model description: pre-post comparison study
Primary purpose: TREATMENT

Brief summary: Periodontitis has been linked to increased risk of cerebrovascular disease. Impaired brain hemodynamics has been suggested as early markers of cerebral macro and microangiopathy. Therefore, the aim of this clinical trial will be to assess the potential effect of periodontal treatment on cerebral hemodynamics in otherwise healthy patients with severe periodontitis over 6 months.


Eligibility criteria: Inclusion Criteria:

* Otherwise healthy subjects with severe periodontitis.

Exclusion Criteria:

* \<10 teeth
* current smokers
* undergo periodontal treatment within the last 6 months.
* receive antibiotics or anti-inflammatory drugs within the last 3 months.

Primary outcomes:
measure: Cerebrovascular reactivity (CvR) (%)
timeFrame: Baseline-6 months
Secondary outcomes:
measure: Pulsatility index
timeFrame: Baseline-6 months
measure: Resistivity index
timeFrame: Baseline-6 months
measure: Serum high sensitivity C-reactive protein (hs-CRP)
timeFrame: Baseline-6 months
measure: Brachial flow-mediated dilatation
timeFrame: Baseline-6 months
measure: Carotid intima-media thickness
timeFrame: Baseline-6 months
measure: Probing pocket depth
timeFrame: Baseline-3 months-6 months
measure: Clinical attachment level
timeFrame: Baseline-3 months-6 months
measure: Full-mouth bleeding score
timeFrame: Baseline-3 months-6 months
measure: Full-mouth plaque score
timeFrame: Baseline-3 months-6 months
Other outcomes:
Locations:
city: Santiago De Compostela
country: Spain
facility: University of Santiago de Compostela
Study officials:
affiliation: University of Santiago de Compostela
name: Yago Leira, PhD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT04424017: Sero-prevalence of Coronavirus Disease 2019 (COVID-19) in Healthcare Workers
Official title: Sero-prevalence of Coronavirus Disease 2019 (COVID-19) in Healthcare Workers
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: COVID
Corona Virus Infection
Lead sponsor: Egyptian Center for Research and Regenerative Medicine
Sponsor class: OTHER_GOV
Collaborators: name: Cairo University
name: National Research Centre, Egypt
name: Academy of Scientific Research and Technology, Egypt
First posted: 2020-06-09
Enrollment: 1546
Sex: ALL
Minimum age (years): 18
Maximum age (years): 60
Standard ages: ADULT
Accepts healthy volunteers: no
Observational model: OTHER
Time perspective: CROSS_SECTIONAL
Sampling method: PROBABILITY_SAMPLE
Study population: Age-stratified sample from general population with 3 subgroups:

1. Healthcare workers (HCWs), comprising frontline doctors, nurses, health attendants, and receptionists.
2. Healthy blood donors and healthy subjects in blood bank or laboratory (routine examinations as pre-employment, likely to be representative of the general population
3. Convalescents

Brief summary: The medical and paramedical staff of the front-line services are potentially exposed to SARS-CoV-2. Therefore, despite the application of standard protective measures, it is possible that a certain number of these personnel have already contracted SARS-CoV-2, including in its asymptomatic form. Serological testing in this context would be useful for deploying immune healthcare workers as to limit the risk of viral infection and transmission. Therefore, it is of utmost importance to prove that the serological response entails the production of neutralizing antibodies.


Eligibility criteria: Inclusion Criteria:

* Not previously diagnosed with COVID-19 except for convalescents
* Not currently symptomatic with fever or respiratory symptoms (cough, dyspnea)

Exclusion Criteria:

* Patients with fever or respiratory symptoms (cough, dyspnea)
* Refusal to give informed consent, or contraindication to venipuncture.

Primary outcomes:
measure: Describe the serological status of individuals in the study by presence of specific anti-SARS-CoV-2 antibodies
timeFrame: 3 Months
Secondary outcomes:
Other outcomes:
Locations:
city: Cairo
country: Egypt
facility: ECRRM
city: Cairo
country: Egypt
facility: Faculty of Medicine, Cairo University
Study officials:
References:
Clinical trial NCT00726817: The Effects of Butyrate Enemas on Visceral Perception
Official title: The Effects of Butyrate Enemas on Visceral Perception
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Visceral (Hyper)Sensitivity
Keywords: butyrate, visceral perception, compliance
Lead sponsor: Maastricht University Medical Center
Sponsor class: OTHER
First posted: 2008-08-01
Enrollment: 11
Sex: ALL
Minimum age (years): 18
Maximum age (years): 65
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: CROSSOVER
Primary purpose: BASIC_SCIENCE

Brief summary: During this double blind, placebo controlled, randomised cross over study, healthy volunteers received an enema once daily for one week containing either placebo (saline), 50mM butyrate or 100mM of butyrate. Before and directly after each test period a barostat protocol was performed to measure parameters for visceral perception.


Eligibility criteria: Inclusion Criteria:

* healthy

Exclusion Criteria:

* age, under 18 or over 65
* use of pre- or probiotics during study and 3 months previous to study
* previous bowel complaints
* gastrointestinal disease or abdominal surgery

Primary outcomes:
Secondary outcomes:
Other outcomes:
Locations:
city: Maastricht
country: Netherlands
facility: Maastricht University
state: Limburg
Study officials:
affiliation: Maastricht University Medical Center
name: Robert-Jan Brummer, Prof
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT01755117: Ultrasound Guided Obturator Nerve Block for Total Knee Replacement (TKR)
Official title: Comparison of Posterior Lumbar Plexus Block Plus Sciatic Nerve Block With Sciatic Plus Femoral Plus Obturator Nerve Block for Total Knee Replacement (TKR)
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Total Knee Replacement
Surgery
Lead sponsor: Larissa University Hospital
Sponsor class: OTHER
First posted: 2012-12-24
Enrollment: 100
Sex: ALL
Minimum age (years): 18
Maximum age (years): 80
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: SUPPORTIVE_CARE

Brief summary: Total Knee Replacement can be performed under the combination of posterior lumbar plexus block plus sciatic nerve block. The investigators can have the same outcome by performing instead of posterior lumbar plexus block more peripheral nerve blocks. More specifically under the combination of sciatic nerve block plus femoral nerve block plus obturator nerve block.


Eligibility criteria: Inclusion Criteria:

* Age 18 - 80 yrs
* ASA I - III
* TKR surgery

Exclusion Criteria:

* Coagulopathy disorders
* Infection at the puncture site for the interscalene block
* Neurologic deficit in the arm that is going to be operated
* Allergy to local anesthetics
* BMI \> 35
* Psychiatric disorders
* Patient's refusal
* Problems with patient communication

Primary outcomes:
measure: Feasibility of TKR surgery under ultrasound guided sciatic nerve block plus femoral nerve block plus obturator nerve block measured with Pain Score on the Visual Analog Scale
timeFrame: Completion of surgery
Secondary outcomes:
measure: Intraoperative opioid consumption for TKR surgery under ultrasound guided sciatic nerve block plus femoral nerve block plus obturator nerve block
timeFrame: Intaoperatively
Other outcomes:
measure: Postoperative opioid consumption
timeFrame: First 24 postoperative hours
Locations:
city: Larissa
country: Greece
facility: Larissa University Hospital
state: Thessally
Study officials:
affiliation: Larissa University Hospital
name: Marina Simaioforidou, Medicine
role: PRINCIPAL_INVESTIGATOR
affiliation: Larissa University Hospital
name: Metaxia Bareka, Medicine
role: STUDY_CHAIR
affiliation: Larissa University Hospital
name: George Basdekis, Medicine
role: STUDY_CHAIR
affiliation: Larissa University Hospital
name: Athanasios Drakos, Medicine
role: STUDY_CHAIR
affiliation: Private Clinic of Larissa Asklipeiio
name: Aristeidis Zibis, Medicine
role: STUDY_CHAIR
affiliation: Larissa University Hospital
name: Konstantinos Alexiou, Medicine
role: STUDY_CHAIR
References:
citation: Enneking FK, Chan V, Greger J, Hadzic A, Lang SA, Horlocker TT. Lower-extremity peripheral nerve blockade: essentials of our current understanding. Reg Anesth Pain Med. 2005 Jan-Feb;30(1):4-35. doi: 10.1016/j.rapm.2004.10.002. No abstract available.
Clinical trial NCT03088917: 'Fibrosis in the Lost Hepatitis C Population - Track, Trace and Treat'
Official title: 'Fibrosis in the Lost Hepatitis C Population - Track, Trace and Treat' A Prospective Cohort Study Assessing the Impact of Loss to Follow-up on Liver Fibrosis in Chronic Hepatitis C.
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Chronic Hepatitis c
Lead sponsor: Radboud University Medical Center
Sponsor class: OTHER
Collaborators: name: Merck Sharp & Dohme LLC
First posted: 2017-03-23
Enrollment: 106
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: lost to follow-up chronic hepatitis C patients in the region Nijmegen. This so-called lost population consists of all patients, that in the past have been diagnosed with hepatitis C at the Radboudumc but who are currently lost to or have been withdrawn from follow-up. The time-span of interest will be 2000-2015.

Brief summary: Objective:

To coordinate active tracing of chronic hepatitis C patients lost to follow-up to inform them about there disease severity and treatment options.

Study design: This is a prospective cohort study, which will start as a pilot study in the Radboudumc Population: lost to follow-up chronic hepatitis C patients in the region Nijmegen. This so-called lost population consists of all patients, that in the past have been identified at the Radboudumc but who are currently lost to or have been withdrawn from follow-up. The time-span of interest will be 2000-2015. We estimate that this project will retrace 100 lost patients through this search.


Eligibility criteria: Inclusion Criteria:

* ever diagnosed with hepatitis C, lost to follow-up

Exclusion Criteria:

* none

Primary outcomes:
measure: Liver Fibrosis Stage
timeFrame: Baseline
Secondary outcomes:
measure: Reasons for Loss to Follow-up
timeFrame: Baseline
measure: Genotype Distribution
timeFrame: Baseline
measure: Fibrosis Progression
timeFrame: Baseline
measure: Treatment Outcome
timeFrame: At least 12 weeks after end of treatment
Other outcomes:
Locations:
city: Nijmegen
country: Netherlands
facility: Radboudumc
state: Gelderland
Study officials:
affiliation: Radboud University Medical Center
name: Joost Drenth, Md,PhD,Prof
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT04122417: The Effect Of Therapeutic Touch To Mothers With Preterm Babies
Official title: The Effect Of Therapeutic Touch Training Given To Mothers With Preterm Babies On Attachment Level And The Responses The Baby
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Therapeutic Touch
Keywords: Therapeutic touch
yakson
gentle human touch
maternal attachment
preterm baby
Lead sponsor: University of Yalova
Sponsor class: OTHER
First posted: 2019-10-10
Enrollment: 90
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: CASE_CONTROL
Time perspective: CROSS_SECTIONAL
Sampling method: NON_PROBABILITY_SAMPLE
Study population: The sample of the study consists of babies and their mothers who were matching the criteria of the research between these dates and who volunteered. As a result of the power analysis, sample size was calculated as 90 for experimental and control groups with Power: 0.80. As a result of the sample calculation a total of 90 mothers and babies; 30 for Yakson group, 30 for gentle human touch group, 30 for control group were included in the study. The assignment of mothers and babies to the experiment and control groups was carried out by randomization with drawing lots method.

Brief summary: The study was carried to determine the effect of yakson or gentle human touch methods applied by the mothers to their preterm newborns on mother's attachment level and baby's response.

Detailed description: The study was carried out as a randomized controlled experimental research. Population of the study is all of the babies who were hospitalized at the neonatal intensive care unit of a state hospital in Turkey between August 2016 and August 2017 and the mothers of the babies; its sample is 90 mothers and their babies included with randomization method who were matching the criteria who were also hospitalized between these dates.

Eligibility criteria: Inclusion Criteria:

Mothers' Selection Criteria

* Mother should not have any defines psychiatric diseases,
* Mother should not have any physical disabilities,
* Mother should be literate and open to communication,
* Should not have transportation problem,
* Should be willing to participate and volunteer for the study.

Babies' Selection Criteria

* Babies should be between 26-34 gestation weeks,
* Should not have congenital abnormalities,
* Babies should not have any health problems that may hinder the practice (Intracranial hemorrhage, sepsis, hemorrhagic diseases, having an operation, etc.).

Exclusion Criteria:

-Participants must have inclusion criterias.

Primary outcomes:
measure: The Effect Of Therapeutic Touch Training Given To Mothers With Preterm Babies On Attachment Level And The Responses The Baby
timeFrame: Between August 2016 and August 2017
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
affiliation: university
name: ŞEYDA CAN, PhD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT03899441: Multimedia Aid Gynecologic Counseling and Consent
Official title: Does Multimedia Perioperative Teaching Improve Patient Experience in the Treatment of Endometrial Cancer
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Endometrium Cancer
Sentinel Lymph Node
Perioperative/Postoperative Complications
Keywords: multimedia, video teaching
Lead sponsor: UNC Lineberger Comprehensive Cancer Center
Sponsor class: OTHER
First posted: 2019-04-02
Enrollment: 87
Sex: FEMALE
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: This is an interventional trial to introduce two short animated videos into preoperative counseling/consent and to compare patient comprehension and satisfaction with a multimedia approach compared to standard of care currently. The investigators anticipate that patients will retain more information about their surgery and peri-operative care and will be more satisfied with a multimedia approach.

Detailed description: The investigators plan a pilot study where patients will be randomized to receiving standard consent and teaching prior to their planned surgery for endometrial cancer or standard consent and multimedia video aid with targeted teaching. This video will be an adjunct to the standard consent process and supplement the pre and post-operative teaching that is currently not formalized. The primary outcome is patient satisfaction. The secondary outcomes include patient understanding and physician satisfaction. The investigators hypothesize that patients will be more satisfied when their consent for surgery is done in conjunction with this multimedia aid.

Eligibility criteria: Inclusion Criteria:

* English-speaking
* Has diagnosis of endometrial cancer
* Planned minimally invasive surgical treatment with hysterectomy and sentinel lymph node biopsy

Exclusion Criteria:

* Non-English speaking
* Pregnant

Primary outcomes:
measure: Patient satisfaction
timeFrame: 1 day (assessed at first visit)
Secondary outcomes:
measure: Patient comprehension
timeFrame: 6-8 weeks (assessed at 3 time points - first clinic visit, inpatient at time of surgery, and at follow-up visit 4-6 weeks after surgery)
measure: Physician satisfaction
timeFrame: 1 day (assessed at first visit)
measure: Visit length
timeFrame: 1 day (assessed during first visit)
Other outcomes:
Locations:
city: Chapel Hill
country: United States
facility: Univeristy of North Carolina at Chapel Hill
state: North Carolina
Study officials:
affiliation: UNC Hospital
name: Katherine Tucker, MD
role: PRINCIPAL_INVESTIGATOR
References: