Clinical trial NCT04070170: Laser Therapy on Orthodontic Tooth Movement
Official title: The Effects of Lower Level Laser Therapy on Orthodontic Tooth Movement
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Laser Therapy
Orthodontic Tooth Movement
Bone Remodeling
Keywords: Low-Level Light Therapy
Tooth Movement
Bone Remodeling
Lead sponsor: Pontifícia Universidade Católica de Minas Gerais
Sponsor class: OTHER
First posted: 2019-08-28
Enrollment: 24
Sex: ALL
Minimum age (years): 13
Maximum age (years): 18
Standard ages: CHILD
ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The aims of this study will be to evaluate if a Lower Level Laser Therapy (LLLT): (1) enhances the levels of important pro-inflammatory chemokines involved in the bone remodeling process; (2) increases the rate of orthodontic tooth movement (OTM) on human subjects.


Eligibility criteria: Inclusion Criteria:

* Facial convexity
* Protrusion or biprotrusion of the incisors
* Dental crowding
* Healthy periodontal condition
* Satisfactory oral hygiene

Exclusion Criteria:

* Patients under medications that may interfere with bone metabolism, such as anti-inflammatory, antibiotics and hormonal supplements in the previous three months
* Skeletal crossbite
* Parafunctional habits
* Occlusal interference

Primary outcomes:
measure: Rate of orthodontic tooth movement, with and without low-level laser therapy
timeFrame: The quantification of OTM was performed before canine retraction
measure: Rate of orthodontic tooth movement, with and without low-level laser therapy
timeFrame: The quantification of OTM was performed after 1 month of canine retraction
measure: Rate of orthodontic tooth movement, with and without low-level laser therapy
timeFrame: The quantification of OTM was performed after 2 months of canine retraction
measure: Rate of orthodontic tooth movement, with and without low-level laser therapy
timeFrame: The quantification of OTM was performed after 3 months of canine retraction
Secondary outcomes:
measure: Chemokine levels in the periodontal tissue after LLLT and orthodontic force
timeFrame: The chemokine levels were assayed on days 0, 1, 7 and 14 after application of orthodontic force and low-level laser therapy
Other outcomes:
Locations:
city: Belo Horizonte
country: Brazil
facility: Pontifical Catholic University of Minas Gerais
state: MG
Study officials:
References:
citation: Doshi-Mehta G, Bhad-Patil WA. Efficacy of low-intensity laser therapy in reducing treatment time and orthodontic pain: a clinical investigation. Am J Orthod Dentofacial Orthop. 2012 Mar;141(3):289-297. doi: 10.1016/j.ajodo.2011.09.009.
citation: Alhashimi N, Frithiof L, Brudvik P, Bakhiet M. Chemokines are upregulated during orthodontic tooth movement. J Interferon Cytokine Res. 1999 Sep;19(9):1047-52. doi: 10.1089/107999099313271.
citation: Torri S, Weber JB. Influence of low-level laser therapy on the rate of orthodontic movement: a literature review. Photomed Laser Surg. 2013 Sep;31(9):411-21. doi: 10.1089/pho.2013.3497. Epub 2013 Jul 24.
citation: Genc G, Kocadereli I, Tasar F, Kilinc K, El S, Sarkarati B. Effect of low-level laser therapy (LLLT) on orthodontic tooth movement. Lasers Med Sci. 2013 Jan;28(1):41-7. doi: 10.1007/s10103-012-1059-6. Epub 2012 Feb 18.
citation: Kim SJ, Moon SU, Kang SG, Park YG. Effects of low-level laser therapy after Corticision on tooth movement and paradental remodeling. Lasers Surg Med. 2009 Sep;41(7):524-33. doi: 10.1002/lsm.20792.