Clinical trial NCT06333548: Cord Blood Alarin Levels in Term Babies
Official title: Comparison of Cord Blood Alarin Levels in Term Babies According to Birth Weight
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Birth Weight
Keywords: NEWBORN
ALARİN
UMBİLİCAL CORD BLOOD
Lead sponsor: Konya City Hospital
Sponsor class: OTHER
First posted: 2024-03-27
Enrollment: 87
Sex: ALL
Minimum age (years): 1
Maximum age (years): 5
Standard ages: CHILD
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Babies born between the planned dates and whose families gave consent for the study were divided into four different groups according to their characteristics:

1. Babies with normal weight according to gestational age (AGA): 25 babies were included in the study.
2. Low weight babies for gestational age (SGA): 20 babies were included in the study.
3. Large-weight babies for gestational age (LGA): 22 babies were included in the study.
4. Babies whose mothers had gestational diabetes mellitus: 20 babies were included in the study.

Brief summary: In this study, alarin levels in the cord blood of babies with large birth weights will be compared with babies of normal weight. Thus, the investigators aimed to find out whether there is a relationship between babies' birth weights and alarin.

Detailed description: Studies have shown that the galanin neuropeptide family plays a role in regulating appetite, insulin resistance, obesity, hypertension and metabolism. Alarin is a peptide consisting of 25 amino acids. Current research shows that allerin plays an important role in the emergence and development of diabetes and obesity. There are studies that found that the serum alarin level increased significantly in patients with impaired glucose tolerance and type 2 diabetes mellitus. Additionally, studies have found that both non-obese and obese type 2 diabetes mellitus serum alarin levels increase.

Studies in the literature are related to adults, and there are no studies on alarin levels in newborn babies.

Based on the alarin studies available in the literature, the investigators determined whether there is a relationship between the alarin level and the baby's birth weight by comparing the alarin level in the cord blood of babies with a high birth weight according to their gestational age (both babies of diabetic mothers and babies of non-diabetic mothers) compared to babies whose birth weight is within the normal range. the investigators aimed to find it.

Eligibility criteria: Inclusion Criteria:

* Babies given consent by their families
* Healthy babies

Exclusion Criteria:

* Babies with syndromic appearance or any accompanying disease
* Babies whose family does not give consent

Primary outcomes:
measure: Comparison of cord blood alarin levels of babies in different groups according to birth weight (low-appropriate-large) and babies of mothers diagnosed with gestational diabetes regardless of birth weight.
timeFrame: postnatal 5 minutes
Secondary outcomes:
Other outcomes:
Locations:
city: Konya
country: Turkey
facility: MELEK
state: Sıhhiye
Study officials:
affiliation: Konya City Hospital
name: MELEK BUYUKEREN
role: STUDY_DIRECTOR
References:
citation: Zhou X, Luo M, Zhou S, Cheng Z, Chen Z, Yu X. Plasma Alarin Level and Its Influencing Factors in Obese Newly Diagnosed Type 2 Diabetes Patients. Diabetes Metab Syndr Obes. 2021 Jan 27;14:379-385. doi: 10.2147/DMSO.S290072. eCollection 2021.
citation: Hu W, Fan X, Zhou B, Li L, Tian B, Fang X, Xu X, Liu H, Yang G, Liu Y. Circulating alarin concentrations are high in patients with type 2 diabetes and increased by glucagon-like peptide-1 receptor agonist treatment: An Consort-compliant study. Medicine (Baltimore). 2019 Jul;98(28):e16428. doi: 10.1097/MD.0000000000016428.