Clinical trial NCT04884841: Development and Validation of Models to Predict Postoperative Complications for Patients With Cardiac Surgery
Official title: Development and Validation of Models to Predict Postoperative Complications for Patients With Cardiac Surgery
Study type: OBSERVATIONAL
Overall status: RECRUITING
Conditions: Surgery--Complications
Lead sponsor: China National Center for Cardiovascular Diseases
Sponsor class: OTHER_GOV
First posted: 2021-05-13
Enrollment: 70000
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: OTHER
Sampling method: PROBABILITY_SAMPLE
Study population: All adult patients who are going to have an cardiovascular operation.

Brief summary: Patients undergoing cardiac surgery is routinely performed in clinical scenarios, highly postoperative morbidities and long-term mortality should be modified. A simple risk prediction model incorporating risk factors can help guide clinical decision making, patient counseling and treatment planning.

Detailed description: Patients undergoing cardiac surgery is routinely performed in clinical scenarios, highly postoperative morbidities and long-term mortality should be modified.A nomogram is a pictorial representation of a scoring model that possesses a simple user interface and shows favorable predictive performance. By integrating a patient's diverse determinant variables, a nomogram can provide a personalized probability for quantitative predictions of the incidence of an outcome of interest.Therefore, we conducted a retrospective study to assess the incidence, risk factors and outcomes associated with major complications patients undergoing cardiac surgery.

Eligibility criteria: Inclusion Criteria:

Age more than 18 years Undergoing Cardiovascular surgery

Exclusion Criteria:

Missing primary outcomes or variables

Primary outcomes:
measure: postoperative complications: acute kidney injury
timeFrame: 30 dyas
measure: postoperative complications: Chronic Kidney disease
timeFrame: 30 days, as follow up
measure: postoperative complications: Infection
timeFrame: 30 days
measure: postoperative complications: delirium
timeFrame: 30 days
measure: postoperative complications: MACCE
timeFrame: 30 days, as follow up
measure: postoperative complications: major bleeding
timeFrame: 30 days
measure: postoperative complications: postoperative pulmonary complications
timeFrame: 30 days
measure: postoperative complications: ECMO
timeFrame: 30 days
measure: postoperative complications: IABP
timeFrame: 30 days
measure: Ventilation time
timeFrame: Through study completion, an average of 7 days
measure: Length of ICU stay
timeFrame: Through study completion, an average of 30 days
Secondary outcomes:
measure: Total hospital costs
timeFrame: Through study completion, an average of 30 days
measure: ICU costs
timeFrame: Through study completion, an average of 30 days
measure: Length of hospital stay
timeFrame: Through study completion, an average of 30 days
measure: Length of postoperative hospital stay
timeFrame: Through study completion, an average of 30 days
Other outcomes:
Locations:
city: Beijing
country: China
facility: Fuwai Hospital, China National Center for Cardiovascular Diseases, CAMS&PUMC
Study officials:
affiliation: China National Center for Cardiovascular Diseases
name: Yuefu Wang, MD
role: PRINCIPAL_INVESTIGATOR
References: