Clinical trial NCT05712200: Study to evaLuate the effIcacy and Safety of abeLacimab in High-risk Patients With Atrial Fibrillation Who Have Been Deemed Unsuitable for Oral antiCoagulation (LILAC-TIMI 76)
Official title: A Phase 3, Multicenter, Randomized, Double-blind, Placebo-controlled, Parallel-group Study to evaLuate the effIcacy and Safety of abeLacimab in High-risk Patients With Atrial Fibrillation Who Have Been Deemed Unsuitable for Oral antiCoagulation (LILAC-TIMI 76)
Study type: INTERVENTIONAL
Overall status: RECRUITING
Phase: PHASE3
Conditions: Atrial Fibrillation (AF)
Keywords: abelacimab
randomized
placebo-controlled
double-blind
endpoint evaluation
atrial fibrillation
Lead sponsor: Anthos Therapeutics, Inc.
Sponsor class: INDUSTRY
First posted: 2023-02-03
Enrollment: 1900
Sex: ALL
Minimum age (years): 65
Standard ages: OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: A study to evaluate the effect of abelacimab relative to placebo on the rate of ischemic stroke or systemic embolism (SE) in patients with Atrial Fibrillation (AF) who have been deemed by their responsible physicians or by their own decision to be unsuitable for oral anticoagulation therapy.


Eligibility criteria: Inclusion Criteria:

* Patient is able to understand and has provided written informed consent to participate in the trial
* Diagnosed Atrial Fibrillation (AF) or atrial flutter (documented on an electrocardiogram (ECG) or monitor recording)
* Age 65-74 and a CHA2DS2VASc ≥4 OR age ≥75 and a CHA2DS2VASc ≥3
* Patient is judged by the responsible physician to be unsuitable for oral anticoagulation because the risks outweigh the benefits or the patient is unwilling to take oral anticoagulation AND this determination was made prior to and independent of the study
* At least 1 bleeding risk factor such as severe renal insufficiency, planned daily use of antiplatelet medication for the duration of the trial, history of bleeding from a critical area, or other conditions associated with increased risk of bleeding such as chronic nonsteroidal anti-inflammatory drug (NSAID) use, frailty or multiple falls
* Patient is judged by the responsible physician to be unsuitable for left atrial appendage (LAA) closure or occlusion device, an approved device is not available, or the patient is unwilling to undergo the procedure AND this determination was made prior to and independent of the study

Exclusion Criteria:

* AF due to an ongoing acute reversible cause (e.g., cardiac surgery, pulmonary embolism (PE), untreated hyperthyroidism, alcohol use)
* Patients who within 60 days prior to randomization (1) received a vitamin K antagonists (VKA) (e.g., warfarin, phenprocoumon, acenocoumarol) or a direct oral anticoagulant (DOAC) such as, dabigatran, rivaroxaban, apixaban, or edoxaban or (2) were newly diagnosed with AF
* Patients with an intracranial or intraocular bleed within the 3 months prior to screening or any history of spontaneous intracerebral hemorrhage at any time in the absence of antithrombotic treatment
* Any stroke within 14 days before randomization or transient ischemic attack (TIA) within 3 days before randomization
* Mechanical heart valve or valve disease that is expected to require mechanical valve replacement intervention (surgical or invasive) during the course of the study
* Patients on dialysis at screening or who are planned to start dialysis within 6 months

Other protocol defined Inclusion/Exclusion criteria may apply

Primary outcomes:
measure: Efficacy: Time to first event of ischemic stroke or systemic embolism (SE)
timeFrame: Up to 30 months
measure: Safety: Time to first occurrence of Bleeding Academic Research Consortium (BARC) type 3c/5 bleeding
timeFrame: Up to 30 months
Secondary outcomes:
measure: Efficacy: Time to first event of ischemic stroke, systemic embolism (SE), myocardial infarctions (MI), venous thromboembolism (VTE), or acute limb ischemia
timeFrame: Up to 30 months
measure: Efficacy: Time to first event of ischemic stroke, systemic embolism (SE), or Bleeding Academic Research Consortium (BARC) type 3c/5 bleeding event
timeFrame: Up to 30 months
measure: Efficacy: Cardiovascular (CV) mortality
timeFrame: Up to 30 months
measure: Efficacy: All-cause mortality
timeFrame: Up to 30 months
measure: Time to first event of ischemic stroke, systemic embolism (SE), myocardial infarctions (MI), venous thromboembolism (VTE), acute limb ischemia, or International Society on Thrombosis and Haemostasis (ISTH) major bleeding
timeFrame: Up to 30 months
Other outcomes:
Locations:
city: Birmingham
country: United States
facility: Anthos Investigative Site 1040
state: Alabama
city: Mobile
country: United States
facility: Anthos Investigative Site 1041
state: Alabama
city: Gilbert
country: United States
facility: Anthos Investigative Site 1089
state: Arizona
city: Peoria
country: United States
facility: Anthos Investigative Site 1099
state: Arizona
city: Phoenix
country: United States
facility: Anthos Investigative Site 9906
state: Arizona
city: Yuma
country: United States
facility: Anthos Investigative Site 9927
state: Arizona
city: Huntington Beach
country: United States
facility: Anthos Investigative Site 9929
state: California
city: Lancaster
country: United States
facility: Anthos Investigative Site 9921
state: California
city: Loma Linda
country: United States
facility: Anthos Investigative Site 1078
state: California
city: Los Angeles
country: United States
facility: Anthos Investigative Site 1077
state: California
city: Northridge
country: United States
facility: Anthos Investigative Site 1015
state: California
city: Redding
country: United States
facility: Anthos Investigative Site 1070
state: California
city: San Dimas
country: United States
facility: Anthos Investigative Site 1071
state: California
city: Santa Ana
country: United States
facility: Anthos Investigative Site 1076
state: California
city: South Gate
country: United States
facility: Anthos Investigative Site 9908
state: California
city: Vista
country: United States
facility: Anthos Investigative Site 9907
state: California
city: Aurora
country: United States
facility: Anthos Investigative Site 1095
state: Colorado
city: Denver
country: United States
facility: Anthos Investigative Site 1049
state: Colorado
city: Stamford
country: United States
facility: Anthos Investigative Site 1012
state: Connecticut
city: Boca Raton
country: United States
facility: Anthos Investigative Site 1013
state: Florida
city: Clearwater
country: United States
facility: Anthos Investigative Site 1025
state: Florida
city: Clearwater
country: United States
facility: Anthos Investigative Site 1022
state: Florida
city: Daytona Beach
country: United States
facility: Anthos Investigative Site 1019
state: Florida
city: Hollywood
country: United States
facility: Anthos Investigative Site 1083
state: Florida
city: Jacksonville
country: United States
facility: Anthos Investigative Site 1008
state: Florida
city: Lake Mary
country: United States
facility: Anthos Investigative Site 9904
state: Florida
city: Lutz
country: United States
facility: Anthos Investigative Site 1093
state: Florida
city: Miami Lakes
country: United States
facility: Anthos Investigative Site 1072
state: Florida
city: Miami
country: United States
facility: Anthos Investigative Site 9933
state: Florida
city: Ormond Beach
country: United States
facility: Anthos Investigative Site 1067
state: Florida
city: Safety Harbor
country: United States
facility: Anthos Investigative Site 1026
state: Florida
city: Saint Augustine
country: United States
facility: Anthos Investigative Site 1002
state: Florida
city: Saint Augustine
country: United States
facility: Anthos Investigative Site 1004
state: Florida
city: Tamarac
country: United States
facility: Anthos Investigative Site 1044
state: Florida
city: Tamarac
country: United States
facility: Anthos Investigative Site 1088
state: Florida
city: Tampa
country: United States
facility: Anthos Investigative Site 1046
state: Florida
city: The Villages
country: United States
facility: Anthos Investigative Site 9911
state: Florida
city: Lithonia
country: United States
facility: Anthos Investigative Site 1052
state: Georgia
city: Macon
country: United States
facility: Anthos Investigative Site 1033
state: Georgia
city: Norcross
country: United States
facility: Anthos Investigative Site 1042
state: Georgia
city: Suwanee
country: United States
facility: Anthos Investigative Site 1003
state: Georgia
city: Park Ridge
country: United States
facility: Anthos Investigative Site 1030
state: Illinois
city: Winfield
country: United States
facility: Anthos Investigative Site 9925
state: Illinois
city: Evansville
country: United States
facility: Anthos Investigative Site 9915
state: Indiana
city: Merrillville
country: United States
facility: Anthos Investigative Site 1098
state: Indiana
city: Wichita
country: United States
facility: Anthos Investigative Site 1016
state: Kansas
city: Alexandria
country: United States
facility: Anthos Investigative Site 1006
state: Louisiana
city: Shreveport
country: United States
facility: Anthos Investigative Site 1043
state: Louisiana
city: Bangor
country: United States
facility: Anthos Investigative Site 1054
state: Maine
city: Baltimore
country: United States
facility: Anthos Investigative Site 1039
state: Maryland
city: Lanham
country: United States
facility: Anthos Investigative Site 1023
state: Maryland
city: Rockville
country: United States
facility: Anthos Investigative Site 1028
state: Maryland
city: Boston
country: United States
facility: Anthos Investigative Site 1082
state: Massachusetts
city: Lansing
country: United States
facility: Anthos Investigative Site 1021
state: Michigan
city: Southgate
country: United States
facility: Anthos Investigative Site 1059
state: Michigan
city: Tupelo
country: United States
facility: Anthos Investigative Site 1017
state: Mississippi
city: Kansa City
country: United States
facility: Anthos Investigative Site 1080
state: Missouri
city: Lincoln
country: United States
facility: Anthos Investigative Site 1066
state: Nebraska
city: Las Vegas
country: United States
facility: Anthos Investigative Site 1036
state: Nevada
city: Las Vegas
country: United States
facility: Anthos Investigative Site 9914
state: Nevada
city: Englewood
country: United States
facility: Anthos Investigative Site 1094
state: New Jersey
city: Albany
country: United States
facility: Anthos Investigative Site 9931
state: New York
city: Brooklyn
country: United States
facility: Anthos Investigative Site 9905
state: New York
city: Middletown
country: United States
facility: Anthos Investigative Site 1014
state: New York
city: Rosedale
country: United States
facility: Anthos Investigative Site 1037
state: New York
city: Westfield
country: United States
facility: Anthos Investigative Site 9924
state: New York
city: Cary
country: United States
facility: Anthos Investigative Site 1065
state: North Carolina
city: Charlotte
country: United States
facility: Anthos Investigative Site 1005
state: North Carolina
city: Durham
country: United States
facility: Anthos Investigative Site 9912
state: North Carolina
city: Fayetteville
country: United States
facility: Anthos Investigative Site 1048
state: North Carolina
city: Henderson
country: United States
facility: Anthos Investigative Site 1035
state: North Carolina
city: Lenoir
country: United States
facility: Anthos Investigative Site 1001
state: North Carolina
city: Beavercreek
country: United States
facility: Anthos Investigative Site 9902
state: Ohio
city: Portland
country: United States
facility: Anthos Investigative Site 1075
state: Oregon
city: Bristol
country: United States
facility: Anthos Investigative Site 1074
state: Pennsylvania
city: Horsham
country: United States
facility: Anthos Investigative Site 1087
state: Pennsylvania
city: Rock HIll
country: United States
facility: Anthos Investigative Site 1032
state: South Carolina
city: Elizabethton
country: United States
facility: Anthos Investigative Site 1050
state: Tennessee
city: Germantown
country: United States
facility: Anthos Investigative Site 1057
state: Tennessee
city: Memphis
country: United States
facility: Anthos Investigative Site 1056
state: Tennessee
city: Allen
country: United States
facility: Anthos Investigative Site 9928
state: Texas
city: Beaumont
country: United States
facility: Anthos Investigative Site 9913
state: Texas
city: El Paso
country: United States
facility: Anthos Investigative Site 1091
state: Texas
city: Greenville
country: United States
facility: Anthos Investigative Site 9930
state: Texas
city: Houston
country: United States
facility: Anthos Investigative Site 1069
state: Texas
city: Houston
country: United States
facility: Anthos Investigative Site 1068
state: Texas
city: Houston
country: United States
facility: Anthos Investigative Site 1097
state: Texas
city: Houston
country: United States
facility: Anthos Investigative Site 9903
state: Texas
city: Houston
country: United States
facility: Anthos Investigative Site 1053
state: Texas
city: Houston
country: United States
facility: Anthos Investigative Site 1064
state: Texas
city: Laredo
country: United States
facility: Anthos Investigative Site 9901
state: Texas
city: McAllen
country: United States
facility: Anthos Investigative Site 1063
state: Texas
city: McKinney
country: United States
facility: Anthos Investigative Site 1096
state: Texas
city: McKinney
country: United States
facility: Anthos Investigative Site 1079
state: Texas
city: Odessa
country: United States
facility: Anthos Investigative Site 1024
state: Texas
city: Port Arthur
country: United States
facility: Anthos Investigative Site 1085
state: Texas
city: Sugar Land
country: United States
facility: Anthos Investigative Site 1090
state: Texas
city: Tomball
country: United States
facility: Anthos Investigative Site 1011
state: Texas
city: Tyler
country: United States
facility: Anthos Investigative Site 9916
state: Texas
city: Victoria
country: United States
facility: Anthos Investigative Site 9910
state: Texas
city: Waco
country: United States
facility: Anthos Investigative Site 1060
state: Texas
city: Webster
country: United States
facility: Anthos Investigative Site 9909
state: Texas
city: Wylie
country: United States
facility: Anthos Investigative Site 1092
state: Texas
city: American Fork
country: United States
facility: Anthos Investigative Site 1084
state: Utah
city: Bountiful
country: United States
facility: Anthos Investigative Site 1031
state: Utah
city: Holladay
country: United States
facility: Anthos Investigative Site 1029
state: Utah
city: Pleasant View
country: United States
facility: Anthos Investigative Site 1038
state: Utah
city: Roy
country: United States
facility: Anthos Investigative Site 1034
state: Utah
city: Falls Church
country: United States
facility: Anthos Investigative Site 1018
state: Virginia
city: Manassas
country: United States
facility: Anthos Investigative Site 1010
state: Virginia
city: Roanoke
country: United States
facility: Anthos Investigative Site 1009
state: Virginia
city: Tacoma
country: United States
facility: Anthos Investigative Site 1073
state: Washington
city: Buenos Aires
country: Argentina
facility: Anthos Investigative Site 1411
city: Buenos Aires
country: Argentina
facility: Anthos Investigative Site 1430
city: Ciudad Autónoma Buenos Aires
country: Argentina
facility: Anthos Investigative Site 1409
city: Ciudad Autónoma de Buenos Aire
country: Argentina
facility: Anthos Investigative Site 1410
city: Ciudad Autónoma de Buenos Aire
country: Argentina
facility: Anthos Investigative Site 1423
city: Coronel Suárez
country: Argentina
facility: Anthos Investigative Site 1429
city: Corrientes
country: Argentina
facility: Anthos Investigative Site 1420
city: Córdoba
country: Argentina
facility: Anthos Investigative Site 1407
city: Córdoba
country: Argentina
facility: Anthos Investigative Site 1414
city: Córdoba
country: Argentina
facility: Anthos Investigative Site 1418
city: Córdoba
country: Argentina
facility: Anthos Investigative Site 1424
city: Córdoba
country: Argentina
facility: Anthos Investigative Site 1427
city: Córdoba
country: Argentina
facility: Anthos Investigative Site 1434
city: Córdoba
country: Argentina
facility: Anthos Investigative Site 1419
city: Córdoba
country: Argentina
facility: Anthos Investigative Site 1431
city: Quilmes
country: Argentina
facility: Anthos Investigative Site 1417
city: Ramos Mejia
country: Argentina
facility: Anthos Investigative Site 1415
city: Salta
country: Argentina
facility: Anthos Investigative Site 1403
city: San Luis
country: Argentina
facility: Anthos Investigative Site 1425
city: San Miguel De Tucumán
country: Argentina
facility: Anthos Investigative Site 1404
city: San Miguel De Tucumán
country: Argentina
facility: Anthos Investigative Site 1435
city: San Nicolas
country: Argentina
facility: Anthos Investigative Site 1436
city: Aracaju
country: Brazil
facility: Anthos Investigative Site 1518
city: Belo Horizonte
country: Brazil
facility: Anthos Investigative Site 1527
city: Belo Horizonte
country: Brazil
facility: Anthos Investigative Site 1528
city: Belo Horizonte
country: Brazil
facility: Anthos Investigative Site 1516
city: Belo Horizonte
country: Brazil
facility: Anthos Investigative Site 1507
city: Blumenau
country: Brazil
facility: Anthos Investigative Site 1513
city: Blumenau
country: Brazil
facility: Anthos Investigative Site 1505
city: Brasília
country: Brazil
facility: Anthos Investigative Site 1535
city: Campina Grande Do Sul
country: Brazil
facility: Anthos Investigative Site 1501
city: Campinas
country: Brazil
facility: Anthos Investigative Site 1503
city: Campinas
country: Brazil
facility: Anthos Investigative Site 1522
city: Campo Grande
country: Brazil
facility: Anthos Investigative Site 1520
city: Canoas
country: Brazil
facility: Anthos Investigative Site 1532
city: Caxias Do Sul
country: Brazil
facility: Anthos Investigative Site 1526
city: Colatina
country: Brazil
facility: Anthos Investigative Site 1542
city: Curitiba
country: Brazil
facility: Anthos Investigative Site 1540
city: Curitiba
country: Brazil
facility: Anthos Investigative Site 1509
city: Goiânia
country: Brazil
facility: Anthos Investigative Site 1525
city: Marília
country: Brazil
facility: Anthos Investigative Site 1502
city: Passo Fundo
country: Brazil
facility: Anthos Investigative Site 1533
city: Porto Alegre
country: Brazil
facility: Anthos Investigative Site 1517
city: Porto Alegre
country: Brazil
facility: Anthos Investigative Site 1519
city: Porto Alegre
country: Brazil
facility: Anthos Investigative Site 1506
city: Porto Alegre
country: Brazil
facility: Anthos Investigative Site 1530
city: Porto Alegre
country: Brazil
facility: Anthos Investigative Site 1512
city: Porto Alegre
country: Brazil
facility: Anthos Investigative Site 1524
city: Porto Alegre
country: Brazil
facility: Anthos Investigative Site 1508
city: Recife
country: Brazil
facility: Anthos Investigative Site 1531
city: Ribeirão Preto
country: Brazil
facility: Anthos Investigative Site 1515
city: Ribeirão Preto
country: Brazil
facility: Anthos Investigative Site 1536
city: Rio De Janeiro
country: Brazil
facility: Anthos Investigative Site 1537
city: Salvador
country: Brazil
facility: Anthos Investigative Site 1510
city: Salvador
country: Brazil
facility: Anthos Investigative Site 1521
city: São Paulo
country: Brazil
facility: Anthos Investigative Site 1534
city: São Paulo
country: Brazil
facility: Anthos Investigative Site 1511
city: São Paulo
country: Brazil
facility: Anthos Investigative Site 1538
city: São Paulo
country: Brazil
facility: Anthos Investigative Site 1539
city: São Paulo
country: Brazil
facility: Anthos Investigative Site 1529
city: Tatuí
country: Brazil
facility: Anthos Investigative Site 1514
city: Teresina
country: Brazil
facility: Anthos Investigative Site 1541
city: Votuporanga
country: Brazil
facility: Anthos Investigative Site 1504
city: Blagoevgrad
country: Bulgaria
facility: Anthos Investigative Site 6014
city: Burgas
country: Bulgaria
facility: Anthos Investigative Site 6026
city: Gabrovo
country: Bulgaria
facility: Anthos Investigative Site 6019
city: Haskovo
country: Bulgaria
facility: Anthos Investigative Site 6032
city: Haskovo
country: Bulgaria
facility: Anthos Investigative Site 6018
city: Panagyurishte
country: Bulgaria
facility: Anthos Investigative Site 6013
city: Pazardzhik
country: Bulgaria
facility: Anthos Investigative Site 6025
city: Pleven
country: Bulgaria
facility: Anthos Investigative Site 6006
city: Pleven
country: Bulgaria
facility: Anthos Investigative Site 6003
city: Plovdiv
country: Bulgaria
facility: Anthos Investigative Site 6007
city: Plovdiv
country: Bulgaria
facility: Anthos Investigative Site 6008
city: Plovdiv
country: Bulgaria
facility: Anthos Investigative Site 6009
city: Plovdiv
country: Bulgaria
facility: Anthos Investigative Site 6004
city: Plovdiv
country: Bulgaria
facility: Anthos Investigative Site 6021
city: Sliven
country: Bulgaria
facility: Anthos Investigative Site 6027
city: Smolyan
country: Bulgaria
facility: Anthos Investigative Site 6022
city: Sofia
country: Bulgaria
facility: Anthos Investigative Site 6030
city: Sofia
country: Bulgaria
facility: Anthos Investigative Site 6028
city: Sofia
country: Bulgaria
facility: Anthos Investigative Site 6024
city: Sofia
country: Bulgaria
facility: Anthos Investigative Site 6023
city: Sofia
country: Bulgaria
facility: Anthos Investigative Site 6010
city: Sofia
country: Bulgaria
facility: Anthos Investigative Site 6015
city: Sofia
country: Bulgaria
facility: Anthos Investigative Site 6020
city: Sofia
country: Bulgaria
facility: Anthos Investigative Site 6001
city: Sofia
country: Bulgaria
facility: Anthos Investigative Site 6017
city: Sofia
country: Bulgaria
facility: Anthos Investigative Site 6012
city: Sofia
country: Bulgaria
facility: Anthos Investigative Site 6002
city: Stara Zagora
country: Bulgaria
facility: Anthos Investigative Site 6011
city: Mira Road
country: Canada
facility: Anthos Investigative Site 2012
state: Nova Scotia
city: Cambridge
country: Canada
facility: Anthos Investigative Site 2003
state: Ontario
city: Chicoutimi
country: Canada
facility: Anthos Investigative Site 2007
state: Quebec
city: Sherbrooke
country: Canada
facility: Anthos Investigative Site 2010
state: Quebec
city: Abbotsford
country: Canada
facility: Anthos Investigative Site 2016
city: Brampton
country: Canada
facility: Anthos Investigative Site 2019
city: Edmonton
country: Canada
facility: Anthos Investigative Site 2015
city: Greenfield Park
country: Canada
facility: Anthos Investigative Site 2018
city: Halifax
country: Canada
facility: Anthos Investigative Site 2005
city: Hamilton
country: Canada
facility: Anthos Investigative Site 2025
city: Montréal
country: Canada
facility: Anthos Investigative Site 2014
city: New Westminster
country: Canada
facility: Anthos Investigative Site 2004
city: North Vancouver
country: Canada
facility: Anthos Investigative Site 2021
city: Québec
country: Canada
facility: Anthos Investigative Site 2002
city: Saint Catharines
country: Canada
facility: Anthos Investigative Site 2024
city: Saint-Jérôme
country: Canada
facility: Anthos Investigative Site 2006
city: Thunder Bay
country: Canada
facility: Anthos Investigative Site 2022
city: Toronto
country: Canada
facility: Anthos Investigative Site 2017
city: Toronto
country: Canada
facility: Anthos Investigative Site 2020
city: Toronto
country: Canada
facility: Anthos Investigative Site 2023
city: Concepción
country: Chile
facility: Anthos Investigative Site 1605
city: Independencia
country: Chile
facility: Anthos Investigative Site 1606
city: Providencia
country: Chile
facility: Anthos Investigative Site 1604
city: San Bernardo
country: Chile
facility: Anthos Investigative Site 1607
city: San Miguel
country: Chile
facility: Anthos Investigative Site 1609
city: Santiago
country: Chile
facility: Anthos Investigative Site 1608
city: Talcahuano
country: Chile
facility: Anthos Investigative Site 1610
city: Temuco
country: Chile
facility: Anthos Investigative Site 1603
city: Temuco
country: Chile
facility: Anthos Investigative Site 1602
city: Viña Del Mar
country: Chile
facility: Anthos Investigative Site 1601
city: Changchun
country: China
facility: Anthos Investigative Site 1818
city: Changsha
country: China
facility: Anthos Investigative Site 1810
city: Changsha
country: China
facility: Anthos Investigative Site 1811
city: Chengdu
country: China
facility: Anthos Investigative Site 1802
city: Haidian
country: China
facility: Anthos Investigative Site 1809
city: Hangzhou
country: China
facility: Anthos Investigative Site 1801
city: Hangzhou
country: China
facility: Anthos Investigative Site 1808
city: Jinan
country: China
facility: Anthos Investigative Site 1816
city: Lianyungang
country: China
facility: Anthos Investigative Site 1804
city: Luoyang
country: China
facility: Anthos Investigative Site 1814
city: Nanchang
country: China
facility: Anthos Investigative Site 1817
city: Nanchang
country: China
facility: Anthos Investigative Site 1820
city: Nanjing
country: China
facility: Anthos Investigative Site 1803
city: Ningbo
country: China
facility: Anthos Investigative Site 1815
city: Shijiazhuang
country: China
facility: Anthos Investigative Site 1819
city: Tianjin
country: China
facility: Anthos Investigative Site 1812
city: Yangzhou
country: China
facility: Anthos Investigative Site 1813
city: Yinchuan
country: China
facility: Anthos Investigative Site 1805
city: Krapinske Toplice
country: Croatia
facility: Anthos Investigative Site 3102
city: Zadar
country: Croatia
facility: Anthos Investigative Site 3109
city: Zagreb
country: Croatia
facility: Anthos Investigative Site 3101
city: Brandýs Nad Labem
country: Czechia
facility: Anthos Investigative Site 3002
city: Liberec
country: Czechia
facility: Anthos Investigative Site 3006
city: Ostrava - Poruba
country: Czechia
facility: Anthos Investigative Site 3007
city: Poděbrady
country: Czechia
facility: Anthos Investigative Site 3001
city: Prague
country: Czechia
facility: Anthos Investigative Site 3003
city: Praha
country: Czechia
facility: Anthos Investigative Site 3005
city: Praha
country: Czechia
facility: Anthos Investigative Site 3004
city: Praha
country: Czechia
facility: Anthos Investigative Site 3010
city: Trutnov
country: Czechia
facility: Anthos Investigative Site 3009
city: Ústí Nad Labem
country: Czechia
facility: Anthos Investigative Site 3011
city: Tallinn
country: Estonia
facility: Anthos Investigative Site 2203
city: Tallinn
country: Estonia
facility: Anthos Investigative Site 2202
city: Tallinn
country: Estonia
facility: Anthos Investigative Site 2201
city: Altenburg
country: Germany
facility: Anthos Investigative Site 7006
city: Berlin
country: Germany
facility: Anthos Investigative Site 7014
city: Dresden
country: Germany
facility: Anthos Investigative Site 7004
city: Hamburg
country: Germany
facility: Anthos Investigative Site 7012
city: Hamburg
country: Germany
facility: Anthos Investigative Site 7003
city: Hannover
country: Germany
facility: Anthos Investigative Site 7013
city: Ludwigshafen
country: Germany
facility: Anthos Investigative Site 7009
city: Markkleeberg
country: Germany
facility: Anthos Investigative Site 7002
city: Paderborn
country: Germany
facility: Anthos Investigative Site 7007
city: Schwerin
country: Germany
facility: Anthos Investigative Site 7001
city: Budapest
country: Hungary
facility: Anthos Investigative Site 4015
city: Budapest
country: Hungary
facility: Anthos Investigative Site 4006
city: Budapest
country: Hungary
facility: Anthos Investigative Site 4009
city: Békéscsaba
country: Hungary
facility: Anthos Investigative Site 4002
city: Gyöngyös
country: Hungary
facility: Anthos Investigative Site 4011
city: Kaposvar
country: Hungary
facility: Anthos Investigative Site 4012
city: Kistarcsa
country: Hungary
facility: Anthos Investigative Site 4007
city: Nyíregyháza
country: Hungary
facility: Anthos Investigative Site 4005
city: Pécs
country: Hungary
facility: Anthos Investigative Site 4010
city: Szeged
country: Hungary
facility: Anthos Investigative Site 4017
city: Veszprém
country: Hungary
facility: Anthos Investigative Site 4016
city: Zalaegerszeg
country: Hungary
facility: Anthos Investigative Site 4008
city: Ahmedabad
country: India
facility: Anthos Investigative Site 2310
city: Ahmedabad
country: India
facility: Anthos Investigative Site 2320
city: Ajmer
country: India
facility: Anthos Investigative Site 2330
city: Bangalore
country: India
facility: Anthos Investigative Site 2311
city: Bhubaneswar
country: India
facility: Anthos Investigative Site 2318
city: Chandigarh
country: India
facility: Anthos Investigative Site 2303
city: Chennai
country: India
facility: Anthos Investigative Site 2324
city: Chennai
country: India
facility: Anthos Investigative Site 2325
city: Dehradun
country: India
facility: Anthos Investigative Site 2328
city: Ghaziabad
country: India
facility: Anthos Investigative Site 2308
city: Jaipur
country: India
facility: Anthos Investigative Site 2306
city: Jaipur
country: India
facility: Anthos Investigative Site 2331
city: Kochi
country: India
facility: Anthos Investigative Site 2304
city: Kolkata
country: India
facility: Anthos Investigative Site 2314
city: Mangaluru
country: India
facility: Anthos Investigative Site 2326
city: Meerut
country: India
facility: Anthos Investigative Site 2329
city: Mumbai
country: India
facility: Anthos Investigative Site 2313
city: Nagpur
country: India
facility: Anthos Investigative Site 2315
city: Nagpur
country: India
facility: Anthos Investigative Site 2316
city: New Delhi
country: India
facility: Anthos Investigative Site 2307
city: New Delhi
country: India
facility: Anthos Investigative Site 2301
city: New Delhi
country: India
facility: Anthos Investigative Site 2319
city: Pune
country: India
facility: Anthos Investigative Site 2305
city: Pune
country: India
facility: Anthos Investigative Site 2317
city: Secunderabad
country: India
facility: Anthos Investigative Site 2309
city: Visakhapatnam
country: India
facility: Anthos Investigative Site 2312
city: Visakhapatnam
country: India
facility: Anthos Investigative Site 2321
city: Afula
country: Israel
facility: Anthos Investigative Site 1210
city: Ashkelon
country: Israel
facility: Anthos Investigative Site 1205
city: Hadera
country: Israel
facility: Anthos Investigative Site 1206
city: Haifa
country: Israel
facility: Anthos Investigative Site 1211
city: Haifa
country: Israel
facility: Anthos Investigative Site 1201
city: H̱olon
country: Israel
facility: Anthos Investigative Site 1209
city: Jerusalem
country: Israel
facility: Anthos Investigative Site 1212
city: Kfar Saba
country: Israel
facility: Anthos Investigative Site 1204
city: Nahariya
country: Israel
facility: Anthos Investigative Site 1202
city: Petah tikva
country: Israel
facility: Anthos Investigative Site 1207
city: Reẖovot
country: Israel
facility: Anthos Investigative Site 1203
city: Zefat
country: Israel
facility: Anthos Investigative Site 1208
city: Ancona
country: Italy
facility: Anthos Investigative Site 8016
city: Bologna
country: Italy
facility: Anthos Investigative Site 8003
city: Brescia
country: Italy
facility: Anthos Investigative Site 8015
city: Caserta
country: Italy
facility: Anthos Investigative Site 8019
city: Catanzaro
country: Italy
facility: Anthos Investigative Site 8008
city: Cinisello Balsamo
country: Italy
facility: Anthos Investigative Site 8021
city: Firenze
country: Italy
facility: Anthos Investigative Site 8024
city: Lecco
country: Italy
facility: Anthos Investigative Site 8013
city: Milano
country: Italy
facility: Anthos Investigative Site 8001
city: Milan
country: Italy
facility: Anthos Investigative Site 8007
city: Naples
country: Italy
facility: Anthos Investigative Site 8026
city: Napoli
country: Italy
facility: Anthos Investigative Site 8023
city: Palermo
country: Italy
facility: Anthos Investigative Site 8017
city: Pisa
country: Italy
facility: Anthos Investigative Site 8025
city: Roma
country: Italy
facility: Anthos Investigative Site 8010
city: Roma
country: Italy
facility: Anthos Investigative Site 8011
city: Roma
country: Italy
facility: Anthos Investigative Site 8002
city: Saronno
country: Italy
facility: Anthos Investigative Site 8004
city: Sesto San Giovanni
country: Italy
facility: Anthos Investigative Site 8005
city: Torino
country: Italy
facility: Anthos Investigative Site 8014
city: Varese
country: Italy
facility: Anthos Investigative Site 8006
city: Vittoria
country: Italy
facility: Anthos Investigative Site 8009
city: Akashi
country: Japan
facility: Anthos Investigative Site 1923
city: Chikushino-shi
country: Japan
facility: Anthos Investigative Site 1908
city: Chuo-Ku
country: Japan
facility: Anthos Investigative Site 1902
city: Funabashi-Shi
country: Japan
facility: Anthos Investigative Site 1920
city: Hamada-shi
country: Japan
facility: Anthos Investigative Site 1910
city: Hamamatsu
country: Japan
facility: Anthos Investigative Site 1924
city: Himeji-Shi
country: Japan
facility: Anthos Investigative Site 1906
city: Imabari-shi
country: Japan
facility: Anthos Investigative Site 1911
city: Isehara-Shi
country: Japan
facility: Anthos Investigative Site 1912
city: Koto-Ku
country: Japan
facility: Anthos Investigative Site 1921
city: Kure-shi
country: Japan
facility: Anthos Investigative Site 1915
city: Matsue
country: Japan
facility: Anthos Investigative Site 1931
city: Matsumoto-Shi
country: Japan
facility: Anthos Investigative Site 1903
city: Nagano-Shi
country: Japan
facility: Anthos Investigative Site 1907
city: Naha
country: Japan
facility: Anthos Investigative Site 1929
city: Osaka
country: Japan
facility: Anthos Investigative Site 1930
city: Sapporo-shi
country: Japan
facility: Anthos Investigative Site 1922
city: Sendai-shi
country: Japan
facility: Anthos Investigative Site 1904
city: Shimonoseki-shi
country: Japan
facility: Anthos Investigative Site 1913
city: Tachikawa-shi
country: Japan
facility: Anthos Investigative Site 1914
city: Tochigi
country: Japan
facility: Anthos Investigative Site 1909
city: Tokushima
country: Japan
facility: Anthos Investigative Site 1925
city: Tokyo
country: Japan
facility: Anthos Investigative Site 1933
city: Toyama
country: Japan
facility: Anthos Investigative Site 1928
city: Tōon
country: Japan
facility: Anthos Investigative Site 1927
city: Urayasu
country: Japan
facility: Anthos Investigative Site 1901
city: Uwajima-Shi
country: Japan
facility: Anthos Investigative Site 1917
city: Yokohama-shi
country: Japan
facility: Anthos Investigative Site 1918
city: Yokohama-Shi
country: Japan
facility: Anthos Investigative Site 1919
city: Yokohama-Shi
country: Japan
facility: Anthos Investigative Site 1916
city: Ōmihachiman
country: Japan
facility: Anthos Investigative Site 1926
city: Baldone
country: Latvia
facility: Anthos Investigative Site 2103
city: Balvi
country: Latvia
facility: Anthos Investigative Site 2109
city: Daugavpils
country: Latvia
facility: Anthos Investigative Site 2107
city: Limbazi
country: Latvia
facility: Anthos Investigative Site 2108
city: Riga
country: Latvia
facility: Anthos Investigative Site 2110
city: Riga
country: Latvia
facility: Anthos Investigative Site 2101
city: Riga
country: Latvia
facility: Anthos Investigative Site 2105
city: Riga
country: Latvia
facility: Anthos Investigative Site 2102
city: Sigulda
country: Latvia
facility: Anthos Investigative Site 2111
city: Valmiera
country: Latvia
facility: Anthos Investigative Site 2104
city: Valmiera
country: Latvia
facility: Anthos Investigative Site 2106
city: Aguascalientes
country: Mexico
facility: Anthos Investigative Site 1701
city: Aguascalientes
country: Mexico
facility: Anthos Investigative Site 1707
city: Aguascalientes
country: Mexico
facility: Anthos Investigative Site 1713
city: Chihuahua
country: Mexico
facility: Anthos Investigative Site 1721
city: Ciudad De México
country: Mexico
facility: Anthos Investigative Site 1712
city: Culiacán
country: Mexico
facility: Anthos Investigative Site 1703
city: Guadalajara
country: Mexico
facility: Anthos Investigative Site 1715
city: Guerrero
country: Mexico
facility: Anthos Investigative Site 1711
city: Monterrey
country: Mexico
facility: Anthos Investigative Site 1704
city: Monterrey
country: Mexico
facility: Anthos Investigative Site 1705
city: Monterrey
country: Mexico
facility: Anthos Investigative Site 1719
city: Querétaro
country: Mexico
facility: Anthos Investigative Site 1702
city: San Luis Potosí
country: Mexico
facility: Anthos Investigative Site 1718
city: Tlalpan
country: Mexico
facility: Anthos Investigative Site 1716
city: Veracruz
country: Mexico
facility: Anthos Investigative Site 1706
city: Veracruz
country: Mexico
facility: Anthos Investigative Site 1708
city: Xalapa
country: Mexico
facility: Anthos Investigative Site 1709
city: Czeladź
country: Poland
facility: Anthos Investigative Site 5022
city: Elbląg
country: Poland
facility: Anthos Investigative Site 5033
city: Gdynia
country: Poland
facility: Anthos Investigative Site 5010
city: Gdynia
country: Poland
facility: Anthos Investigative Site 5034
city: Katowice
country: Poland
facility: Anthos Investigative Site 5003
city: Katowice
country: Poland
facility: Anthos Investigative Site 5009
city: Katowice
country: Poland
facility: Anthos Investigative Site 5030
city: Katowice
country: Poland
facility: Anthos Investigative Site 5005
city: Kraków
country: Poland
facility: Anthos Investigative Site 5016
city: Kraków
country: Poland
facility: Anthos Investigative Site 5018
city: Legnica
country: Poland
facility: Anthos Investigative Site 5032
city: Lublin
country: Poland
facility: Anthos Investigative Site 5023
city: Lublin
country: Poland
facility: Anthos Investigative Site 5006
city: Olsztyn
country: Poland
facility: Anthos Investigative Site 5008
city: Oświęcim
country: Poland
facility: Anthos Investigative Site 5025
city: Przemyśl
country: Poland
facility: Anthos Investigative Site 5002
city: Rzeszów
country: Poland
facility: Anthos Investigative Site 5004
city: Tychy
country: Poland
facility: Anthos Investigative Site 5001
city: Warszawa
country: Poland
facility: Anthos Investigative Site 5014
city: Warszawa
country: Poland
facility: Anthos Investigative Site 5017
city: Warszawa
country: Poland
facility: Anthos Investigative Site 5011
city: Warszawa
country: Poland
facility: Anthos Investigative Site 5015
city: Wrocław
country: Poland
facility: Anthos Investigative Site 5019
city: Wrocław
country: Poland
facility: Anthos Investigative Site 5007
city: Zabrze
country: Poland
facility: Anthos Investigative Site 5024
city: Łódź
country: Poland
facility: Anthos Investigative Site 5012
city: Łódź
country: Poland
facility: Anthos Investigative Site 5028
city: Baloteşti
country: Romania
facility: Anthos Investigative Site 9022
city: Braşov
country: Romania
facility: Anthos Investigative Site 9028
city: Brăila
country: Romania
facility: Anthos Investigative Site 9001
city: Bucharest
country: Romania
facility: Anthos Investigative Site 9023
city: Bucuresti
country: Romania
facility: Anthos Investigative Site 9019
city: Cluj-Napoca
country: Romania
facility: Anthos Investigative Site 9024
city: Craiova
country: Romania
facility: Anthos Investigative Site 9017
city: Craiova
country: Romania
facility: Anthos Investigative Site 9006
city: Oradea
country: Romania
facility: Anthos Investigative Site 9010
city: Piteşti
country: Romania
facility: Anthos Investigative Site 9025
city: Piteşti
country: Romania
facility: Anthos Investigative Site 9014
city: Satu Mare
country: Romania
facility: Anthos Investigative Site 9012
city: Timişoara
country: Romania
facility: Anthos Investigative Site 9007
city: Timişoara
country: Romania
facility: Anthos Investigative Site 9005
city: Timişoara
country: Romania
facility: Anthos Investigative Site 9018
city: Timişoara
country: Romania
facility: Anthos Investigative Site 9013
city: Timişoara
country: Romania
facility: Anthos Investigative Site 9008
city: Târgu-Mureş
country: Romania
facility: Anthos Investigative Site 9003
city: Târgu-Mureş
country: Romania
facility: Anthos Investigative Site 9004
city: Târgu-Mureş
country: Romania
facility: Anthos Investigative Site 9016
city: Târgu-Mureş
country: Romania
facility: Anthos Investigative Site 9021
city: Belgrade
country: Serbia
facility: Anthos Investigative Site 2901
city: Belgrade
country: Serbia
facility: Anthos Investigative Site 2909
city: Užice
country: Serbia
facility: Anthos Investigative Site 2902
city: Zaječar
country: Serbia
facility: Anthos Investigative Site 2907
city: Bardejov
country: Slovakia
facility: Anthos Investigative Site 2801
city: Lučenec
country: Slovakia
facility: Anthos Investigative Site 2806
city: Piešťany
country: Slovakia
facility: Anthos Investigative Site 2802
city: Žilina
country: Slovakia
facility: Anthos Investigative Site 2804
city: Bellville
country: South Africa
facility: Anthos Investigative Site 2411
city: Benoni
country: South Africa
facility: Anthos Investigative Site 2409
city: Cape Town
country: South Africa
facility: Anthos Investigative Site 2417
city: Centurion
country: South Africa
facility: Anthos Investigative Site 2408
city: Durban
country: South Africa
facility: Anthos Investigative Site 2412
city: Johannesburg
country: South Africa
facility: Anthos Investigative Site 2416
city: Pretoria
country: South Africa
facility: Anthos Investigative Site 2402
city: Pretoria
country: South Africa
facility: Anthos Investigative Site 2414
city: Somerset West
country: South Africa
facility: Anthos Investigative Site 2415
city: Tongaat
country: South Africa
facility: Anthos Investigative Site 2405
city: A Coruña
country: Spain
facility: Anthos Investigative Site 1108
city: Almería
country: Spain
facility: Anthos Investigative Site 1116
city: Barcelona
country: Spain
facility: Anthos Investigative Site 1121
city: Barcelona
country: Spain
facility: Anthos Investigative Site 1120
city: Cabra
country: Spain
facility: Anthos Investigative Site 1109
city: Granada
country: Spain
facility: Anthos Investigative Site 1103
city: Jaén
country: Spain
facility: Anthos Investigative Site 1111
city: León
country: Spain
facility: Anthos Investigative Site 1118
city: Madrid
country: Spain
facility: Anthos Investigative Site 1104
city: Madrid
country: Spain
facility: Anthos Investigative Site 1117
city: Madrid
country: Spain
facility: Anthos Investigative Site 1106
city: Madrid
country: Spain
facility: Anthos Investigative Site 1113
city: Murcia
country: Spain
facility: Anthos Investigative Site 1110
city: Málaga
country: Spain
facility: Anthos Investigative Site 1105
city: Oviedo
country: Spain
facility: Anthos Investigative Site 1115
city: Sabadell
country: Spain
facility: Anthos Investigative Site 1123
city: Santiago De Compostela
country: Spain
facility: Anthos Investigative Site 1107
city: Sevilla
country: Spain
facility: Anthos Investigative Site 1102
city: Sevilla
country: Spain
facility: Anthos Investigative Site 1122
city: Terrassa
country: Spain
facility: Anthos Investigative Site 1112
city: Valencia
country: Spain
facility: Anthos Investigative Site 1101
city: Vigo
country: Spain
facility: Anthos Investigative Site 1119
city: Stockholm
country: Sweden
facility: Anthos Investigative Site 3301
city: Corby
country: United Kingdom
facility: Anthos Investigative Site 1303
city: Glasgow
country: United Kingdom
facility: Anthos Investigative Site 1313
city: Hayle
country: United Kingdom
facility: Anthos Investigative Site 1315
city: High Wycombe
country: United Kingdom
facility: Anthos Investigative Site 1311
city: Isleworth
country: United Kingdom
facility: Anthos Investigative Site 1301
city: King's Lynn
country: United Kingdom
facility: Anthos Investigative Site 1316
city: Leeds
country: United Kingdom
facility: Anthos Investigative Site 1309
city: London
country: United Kingdom
facility: Anthos Investigative Site 1314
city: London
country: United Kingdom
facility: Anthos Investigative Site 1319
city: London
country: United Kingdom
facility: Anthos Investigative Site 1308
city: Manchester
country: United Kingdom
facility: Anthos Investigative Site 1312
city: Newcastle Upon Tyne
country: United Kingdom
facility: Anthos Investigative Site 1307
city: Norwich
country: United Kingdom
facility: Anthos Investigative Site 1318
city: Peterborough
country: United Kingdom
facility: Anthos Investigative Site 1305
city: Stevenage
country: United Kingdom
facility: Anthos Investigative Site 1302
city: Stockton-on-Tees
country: United Kingdom
facility: Anthos Investigative Site 1310
city: Stoke-on-Trent
country: United Kingdom
facility: Anthos Investigative Site 1317
city: Taunton
country: United Kingdom
facility: Anthos Investigative Site 1306
Study officials:
References: