louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT07020130: Risk Factors,PREvention and OutComes for CI-AKI in PatientS undErgoing PCI (PRECISE)
Official title: Risk Factors,PREvention and outComes for Contrast-Induced Acute Kidney Injury in patientS undErgoing Percutaneous Coronary Intervention：a Single-center Cohort Study(PRECISE)
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: CIN
Lead sponsor: Fujian Provincial Hospital
Sponsor class: OTHER
First posted: 2025-06-13
Enrollment: 3030
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: All Critically ill patients undergoing PCI at ICU were enrolled

Brief summary: A prospective observational study included all patients undergoing percutaneous coronary intervention(PCI) in Fujian Provincial Hospital from January 1st 2012 to December 31st 2018. The aim was to determine the incidence,risk factors,prophylactic strategy and outcomes of CI-AKI in patients undergoing PCI.


Eligibility criteria: Inclusion Criteria:

* Critically ill patients undergoing PCI at ICU

Exclusion Criteria:

* pregnancy lactation end-stage renal disease (eGFR \<15 mL/min/1.73 m2) long-term dialysis treatment intravascular administration of contrast medium within the last 7 or 3 days postoperatively

Primary outcomes:
measure: CI-AKI
timeFrame: 5 year
measure: CKD
timeFrame: 5 year
Secondary outcomes:
measure: all-cause mortality
timeFrame: 5 year
Other outcomes:
Locations:
city: Fuzhou,
country: China
state: Fujian
Study officials:
References:
Clinical trial NCT05687630: Effect of Technology-assisted Physical Therapy for Patient With High Risk of Sarcopenia
Official title: Effect of Technology-assisted Physical Therapy for Patient With High Risk of Sarcopenia
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Sarcopenia
Keywords: sarcopenia
Lead sponsor: National Taiwan University Hospital
Sponsor class: OTHER
First posted: 2023-01-18
Enrollment: 100
Sex: ALL
Minimum age (years): 65
Standard ages: OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: This research aims to identify whether the effects of video-assisted physical therapy, including home resistance training, is superior to traditional physical therapy, education leaflet for example.

This is an interventional research, single-blind, randomized control trail. We recruit high risk of sarcopenia people (low muscle strength and low physical performance) Two groups of participants are divided into traditional group and video-assisted group, both group are taught the same resisted exercise by physical therapist.

Detailed description: Both group will record his/her baseline activity level with a given pedometer. After one week recording, we started initial evaluation (history taking, physical examination) and intervention.

Participants are taught thera-band resisted exercise, including large musculature of upper and lower extremities, each exercise are conducted 10-15 times for 3 sets.

Traditional group will receive an education leaflet and a notebook to record his/ her daily activity and frequency of exercise to record the compliance.

Video-assisted group will receive a QR code, which contain a website of exercise video on the cloud.

After 3 months intervention, participant will come back to our center for final examination.

Eligibility criteria: Inclusion Criteria:

* Age above 65 years old
* MMSE \> 24 points
* walking more than 6 meters independently

Exclusion Criteria:

* people who cannot participate for 3 -day exercise for each week

Primary outcomes:
measure: Grip strength
timeFrame: three months after initial evaluation
measure: walking speed
timeFrame: three months after initial evaluation
measure: Timed up-and-go test
timeFrame: three months after initial evaluation
Secondary outcomes:
measure: Short Physical Performance Battery (SPPB)
timeFrame: three months after initial evaluation
Other outcomes:
Locations:
Study officials:
affiliation: National Taiwan University Hospital
name: Chen Yu Kuo, Bachelor
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT05496530: Custom Needle Preparation for Suprachoroidal Steroid Injection (One Year Results)
Official title: One Year Results for Suprachoroidal Triamcinolone Acetonide Injection in Various Retinal Diseases
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Diabetic Macular Edema
Vogt Koyanagi Harada Disease
Retinal Vein Occlusion
Lead sponsor: Benha University
Sponsor class: OTHER
First posted: 2022-08-11
Enrollment: 100
Sex: ALL
Minimum age (years): 30
Maximum age (years): 80
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: Suprachoroidal drug delivery is a recent route for managing various ocular conditions. Safety and long term results are still under investigations.

Detailed description: In this study, we aim to analyze the long term results of suprachoroidal injection in treating various retinal diseases to focus on its efficacy, safety and long term ocular effects as ocular hypertension, cataract progression and macular edema resolution.

Eligibility criteria: Inclusion Criteria:

* cases with central macular thickness more than 250 microns measured by optical coherence tomography due to one of the following conditions:
* Diabetic macular edema
* Vogt-koyanagi Harada disease
* Retinal vein occlusion.

Exclusion Criteria:

* other causes of increased macular thickness as age related macular degeneration and myopic choroidal new vascularization.
* Cases with confirmed diagnosis of glaucoma.

Primary outcomes:
measure: Visual acuity
timeFrame: Baseline and up to one year after injection.
Secondary outcomes:
measure: Central macular thickness
timeFrame: Baseline and up to one year after injection.
Other outcomes:
measure: Intraocular pressure
timeFrame: Baseline and up to one year after injection.
Locations:
city: Banhā
country: Egypt
facility: Ahmed Abdelshafy Tabl
state: Benha
Study officials:
affiliation: Benha University
name: Ahmed A Tabl
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT05254730: Using Micro-filaments to Detect "fast Ripples" and Improve the Identification of the Epileptogenic Zone
Official title: Using Micro-filaments to Detect "fast Ripples" and Improve the Identification of the Epileptogenic Zone
Study type: INTERVENTIONAL
Overall status: RECRUITING
Phase: NA
Conditions: Epilepsy, Refractory
Lead sponsor: McGill University
Sponsor class: OTHER
First posted: 2022-02-24
Enrollment: 45
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: BASIC_SCIENCE

Brief summary: record fast ripples with novel intracranial electrodes with micro-tetrodes to improve the identification of epileptogenic zone (EZ) and investigate the neuronal circuits underlying brain dynamics associated with epilepsy

Detailed description: This study would improve the localization of the epileptogenic zone and reduce the overall duration of monitoring, especially in patients who do not experience a sufficient number of seizures during the implantation period. In addition, it would be possible to use micro-electrodes and propose a better surgical treatment to some patients whose preliminary assessment with macro-electrodes has not provided significant results. Finally, the data collected during this study will help us to further understand pathological brain activity and to describe the neuronal circuitry that gives rise to cortical signals and the relationships between them (from spindles to high frequency oscillations).

Eligibility criteria: Inclusion Criteria:

* inclusion criteria is determined based on the clinical diagnosis of the refractory epilepsy and the admissibility of the patient for the stereoelectroencephalography (sEEG) procedure

Exclusion Criteria:

* severe psychiatric disorders,
* severe agitation during their crisis
* contraindication for performing an MRI: claustrophobia, a cardiac or neural stimulator, ferromagnetic surgical clips, cochlear implants, intraocular metallic foreign body or in the nervous system,
* contraindication to intracerebral investigation (macro-electrodes): ongoing infection, severe associated pathology (cardiac, pulmonary, renal, hepatic), pregnant or nursing women,
* anti thrombotic ongoing treatment.

Primary outcomes:
measure: evaluate the recording of fast ripples (FRs) and single neuron activity in the brain with the micro tetrodes
timeFrame: 1 week after implant
Secondary outcomes:
measure: Efficiency of microelectrodes compared to macroelectrodes
timeFrame: 10 days after implant
Other outcomes:
Locations:
city: Montreal
country: Canada
facility: McGill University
state: Quebec
Study officials:
References:
Clinical trial NCT04834830: Evaluation and Importance of the PD-1/PD-L1 and the IL-10/IL-10R Axis in Malignant and Benign Pleural Effusions - a Pilot Study
Official title: Evaluation and Importance of the PD-1/PD-L1 and the IL-10/IL-10R Axis in Malignant and Benign Pleural Effusions - a Pilot Study
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Pleural Effusion
Lead sponsor: University of Vienna
Sponsor class: OTHER
First posted: 2021-04-08
Enrollment: 80
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Patients with malignant or benign pleural effusions requiring diagnostic and/or therapeutic procedures including thoracocentesis, drainage insertion, indwelling pleural catheter (IPC) management, and/or video-assisted thoracoscopic surgery

Brief summary: The aim of this study is to evaluate the concentrations of interleukin-2, interleukin-10, interferon-gamma, PD1+ lymphocytes, and the interleukin-10 receptor expression in malignant and benign effusions.

Detailed description: In this prospective trial, 80 patients with pleural effusions and indication for thoracocentesis, drainage, indwelling pleural catheter (IPC) management and/or video-assisted thoracoscopic surgery are enrolled. The pleural effusion will be examined for different cytokines, cytokine-receptors, PD1-lymphocytes and CD4+/CD25+/Foxp3+ regulatory T cell.

Eligibility criteria: Inclusion Criteria:

* age \>18 years
* radiologically confirmed pleural effusion with an indication for puncture, pleural drain insertion, or video-assisted thoracoscopy for diagnostic and/or therapeutic reasons
* Signed declaration of consent

Exclusion Criteria:

* Withdrawal or cessation of participation

Primary outcomes:
measure: To assess and compare the concentration of various cytokines and PD1-lymphoytes in malignant and benign pleural effusions
timeFrame: 12 months
Secondary outcomes:
Other outcomes:
Locations:
city: Vienna
country: Austria
facility: Medical University of Vienna
Study officials:
References:
Clinical trial NCT05324930: Evaluating the Effectiveness of Piscean Derived Collagen Dressing on Neuropathic Diabetic Foot Ulcer in T2DM Patients
Official title: Evaluating the Effectiveness of Collagen Matrix Dressing on Neuropathic Diabetic Foot Ulcer in T2DM Patients: a Randomised Control Trial
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Diabetic Foot Ulcer Neuropathic
Diabetic Foot Ulcer
Lead sponsor: Corporacion Parc Tauli
Sponsor class: OTHER
First posted: 2022-04-13
Enrollment: 180
Sex: ALL
Minimum age (years): 30
Maximum age (years): 60
Standard ages: ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Intervention model description: Double blinded, randomized control trial
Primary purpose: TREATMENT

Brief summary: Diabetic foot ulcers (DFU) are challenging to treat with complicated healing processes and require advanced wound care. Piscean collagen has the potential to promote the regenerative process while remaining cost-effective and with minimal side effects. In this study, the efficacy of a piscean collagen matrix dressing was compared with a standard dressing of saline-moistened gauze for wound healing in patients with neuropathic DFU.

This is a double-blinded, randomised clinical trial.

Detailed description: Diabetic foot ulcers (DFU) are challenging to treat with complicated healing processes and require advanced wound care. Piscean collagen has the potential to promote the regenerative process while remaining cost-effective and with minimal side effects. In this study, the efficacy of a piscean collagen matrix dressing was compared with a standard dressing of saline-moistened gauze for wound healing in patients with neuropathic DFU.

This is a double-blinded, randomised clinical trial. After conventional therapy consisting of debridement, infection control and offloading, patients were randomly allocated to receive either a piscean matrix dressing (the study group) or a saline-moistened gauze dressing (control group) for wound care. The reduction in DFU size and the number of patients with complete healing were measured throughout the treatment and in follow-up.

Eligibility criteria: Inclusion Criteria:

* patients with neuropathic DFUs at Grades I or II for a period of at least 12 weeks, based on the Wagner classification;
* be able to understand simple instructions and provided voluntary, signed informed consent.

Exclusion Criteria:

* active infection which might lead to hospitalisation, gangrene,
* systemic inflammatory or autoimmune disease
* renal failure
* presence of ischaemia or osteomyelitis

Primary outcomes:
measure: Change in DFU size
timeFrame: 3 months
Secondary outcomes:
measure: Complete wound healing
timeFrame: 3 months
Other outcomes:
Locations:
city: Lahore
country: Pakistan
facility: Zainab Khan
state: Punjab
Study officials:
affiliation: Punjab Care hospital
name: Zainab Khan, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT06203730: Study on the Influence of Dyadic Psychoeducational Intervention on Patients With Maintenance Hemodialysis
Official title: Application of Dyadic Psychological Intervention Strategy Based on Double ABC-X Model in Patients With Maintenance Hemodialysis
Study type: INTERVENTIONAL
Overall status: RECRUITING
Phase: NA
Conditions: End Stage Renal Disease on Dialysis
Keywords: double ABC-X model; MHD; quality of life; dyadic psychological intervention strategy
Lead sponsor: Jiangsu Taizhou People's Hospital
Sponsor class: OTHER
First posted: 2024-01-12
Enrollment: 80
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: This study aims explored the effectiveness of dual psychological intervention strategies in improving the quality of life of MHD patients based on the theoretical guidance of double ABC-X model. To provide a scientific and effective dual psychological intervention strategy for MHD patients and their caregivers, in order to improve the quality of life of MHD patients, and to provide a reference for nurses in clinical blood purification centers to implement psychological intervention.


Eligibility criteria: Inclusion Criteria:

* The inclusion criteria of MHD patients were: (1) meeting the diagnostic criteria of CKD; (2) Maintenance hemodialysis at the blood purification center of our hospital for more than 3 months; (3) over 18 years of age; (4) Volunteer to participate in this study.
* MHD caregiver inclusion criteria: (1) over 18 years of age; (2) Responsible for the main care tasks of MHD patients; (3) Volunteer to participate in this study.

Exclusion Criteria:

* Exclusion criteria for MHD patients: (1) Patients with cognitive impairment or audio-visual impairment unable to communicate normally; (2) Patients diagnosed with mental illness or who are receiving medication or psychotherapy for depression.
* MHD caregiver exclusion criteria: (1) Caregivers with cognitive impairment or audiovisual impairment unable to communicate normally; (2) Caregivers suffering from serious heart, brain, liver, kidney and other important organ diseases; (3) carers or paid carers.

Primary outcomes:
measure: quality of life of patients with MHD
timeFrame: "Baseline" and "Immediately after the intervention"
measure: anxiety of patients with MHD
timeFrame: "Baseline" and "Immediately after the intervention"
measure: depression of patients with MHD
timeFrame: "Baseline" and "Immediately after the intervention"
Secondary outcomes:
measure: anxiety of caregivers burden
timeFrame: "Baseline" and "Immediately after the intervention"
measure: depression of caregivers
timeFrame: "Baseline" and "Immediately after the intervention"
measure: caregivers'burden
timeFrame: "Baseline" and "Immediately after the intervention"
measure: Caregiving competence of caregivers
timeFrame: "Baseline" and "Immediately after the intervention"
Other outcomes:
Locations:
city: Taizhou
country: China
facility: Taizhou People's Hospital
state: Jiangsu
Study officials:
References:
Clinical trial NCT00624130: Yasmin 20 Cycle Control - Yasmin 20 Versus Mercilon in Healthy Female Volunteers
Official title: Open, Randomized, Parallel Multi-center Comparison of Cycle Control and Safety of the Oral Contraceptive Yasmin 20 in a 24-day Regimen vs. Mercilon for 7 Cycles in 440 Healthy Female Volunteers
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE3
Conditions: Contraception
Keywords: Contraception,
Cycle control,
Bleeding pattern
Lead sponsor: Bayer
Sponsor class: INDUSTRY
First posted: 2008-02-26
Enrollment: 453
Sex: FEMALE
Minimum age (years): 18
Maximum age (years): 35
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: PREVENTION

Brief summary: The purpose of this study is to compare bleeding pattern of contraceptive Yasmin 20 to a marketed comparator.


Eligibility criteria: Inclusion Criteria:

* Healthy female volunteer aged 18-35,
* Smokers 18-30

Exclusion Criteria:

* Contraindications for using hormonal contraceptives

Primary outcomes:
measure: Cycle control and bleeding pattern
timeFrame: 7 cycles
Secondary outcomes:
measure: Pearl index
timeFrame: 7 cycles
measure: Laboratory tests
timeFrame: Screening
measure: Adverse Events
timeFrame: 7 cycles
measure: General Physical and gynecological examinations
timeFrame: Screening
measure: Vital signs
timeFrame: Screening, admission
measure: Body weight
timeFrame: Screening, admission
Other outcomes:
Locations:
city: Horn
country: Austria
city: Leibnitz
country: Austria
city: Moedling
country: Austria
city: St. Poelten
country: Austria
city: Wien
country: Austria
city: Woergl
country: Austria
city: Paernu
country: Estonia
city: Talinn
country: Estonia
city: Tartu
country: Estonia
city: Helsinki
country: Finland
city: Helsinki
country: Finland
city: Tampere
country: Finland
city: Turku
country: Finland
city: Kaunas
country: Lithuania
city: Kaunas
country: Lithuania
city: Vilnius
country: Lithuania
city: Vilnius
country: Lithuania
Study officials:
affiliation: Bayer
name: Bayer Study Director
role: STUDY_DIRECTOR
References:
citation: Anttila L, Neunteufel W, Petraglia F, Marr J, Kunz M. Cycle control and bleeding pattern of a 24/4 regimen of drospirenone 3 mg/ethinylestradiol 20 mug compared with a 21/7 regimen of desogestrel 150 mug/ethinylestradiol 20 mug: a pooled analysis. Clin Drug Investig. 2011;31(8):519-525. doi: 10.2165/11590260-000000000-00000.
citation: Anttila L, Bachmann G, Hernadi L, Kunz M, Marr J, Klipping C. Contraceptive efficacy of a combined oral contraceptive containing ethinyloestradiol 20 mug/drospirenone 3mg administered in a 24/4 regimen: a pooled analysis of four open-label studies. Eur J Obstet Gynecol Reprod Biol. 2011 Apr;155(2):180-2. doi: 10.1016/j.ejogrb.2010.12.037. Epub 2011 Feb 1.
Clinical trial NCT02000830: Follow up Study of Patients Having Participated in Clinical Trial 64,185-204
Official title: A Four-Year Blinded Outcomes Follow-up Study of Patients Who Received Stannsoporfin or Placebo in Clinical Trial 64,185-204
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Hyperbilirubinemia, Neonatal
Keywords: stannsoporfin
Lead sponsor: Mallinckrodt
Sponsor class: INDUSTRY
First posted: 2013-12-04
Enrollment: 68
Sex: ALL
Minimum age (years): 30
Maximum age (years): 52
Standard ages: CHILD
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: Patients who received a single dose of trial medication in clinical trial 64,185-204.

Brief summary: The objectives of this follow up study are to evaluate the long-term effects of stannsoporfin (Stanate) on the health, growth, and development of patients who received a single dose of stannsoporfin with PT used to treat hyperbilirubinemia compared with patients in the control (placebo plus PT) group in clinical trial 64,185-204.

Detailed description: Outcomes will be based on the following variables:

Reported AEs and SAEs Hearing assessments Developmental assessments

Eligibility criteria: Inclusion Criteria:

* Patients who received IMP (stannsoporfin or placebo) in clinical trial 64,185-204
* Parents or guardians have given written informed consent to participate

Primary outcomes:
measure: Reported adverse events (AEs)
timeFrame: 48-52 month
Secondary outcomes:
measure: Hearing assessments
timeFrame: 48 - 52 month
measure: Developmental assessments
timeFrame: 48 - 52 month
Other outcomes:
Locations:
Study officials:
affiliation: InfaCare Pharmaceuticals Corporation, a Mallinckrodt Company
name: Global Clinical Leader, MD
role: STUDY_CHAIR
References:
Clinical trial NCT01197430: Vertical Stability Training Effects on the Eye-Hand Coordination of Female Volleyball Players
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE1
PHASE2
Conditions: Healthy
Keywords: volleyball
neck vertical stability training
eye-hand coordination
Lead sponsor: Taipei Physical Education College
Sponsor class: OTHER
First posted: 2010-09-09
Enrollment: 23
Sex: FEMALE
Minimum age (years): 17
Maximum age (years): 21
Standard ages: CHILD
ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: CROSSOVER

Brief summary: Purpose: Optimal eye-hand coordination is important for volleyball players. Neck disorder may affect neck function and subsequently eye-hand coordination. The purpose of this study is to explore the vertical stability training effects on coordination of the upper extremities of female volleyball players.

Methods: This study surveyed 25 players of a volleyball team, randomly assigned into the group A (training 1st) and group B (training 2nd). The group A includes 13 volleyball players and the group B includes 12. Eye-hand coordination was tested by a self-developed hand-stroking table device and stay time and motion time of upper extremities were determined. There are two testing modes, regular and random. Motion time for the electric probe moving between target sensor and stay time for the electric probe staying on a target sensors were collected for each mode, before each session of training and after the end of the 2nd session. In the 1st session of training, group A started vertical stability training and group B did control training for six weeks. In the 2nd session of training, the training programs were shifted between group A and B for another six weeks.


Eligibility criteria: Inclusion Criteria:

* Female Volleyball Players

Exclusion Criteria:

* can't party in training

Primary outcomes:
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
References: