Clinical trial NCT02529917: The Benefits of Hemp Protein Supplementation During Resistance Training
Official title: The Benefits of Hemp Protein Supplementation During Resistance Training
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Sarcopenia
Lead sponsor: University of Saskatchewan
Sponsor class: OTHER
First posted: 2015-08-20
Enrollment: 34
Sex: ALL
Minimum age (years): 18
Maximum age (years): 45
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: OTHER

Brief summary: Forty physically active men and women aged 18-45y will take part in an 8-week resistance training program, randomized (double blind) 1:1 into each of two groups. Twenty participants will be randomized to receive 60 g/d of hemp powder (containing approximately 40 g protein and 9 g oil) supplementation and 20 randomized to receive 60 g/d of soy supplementation (matched to the hemp for macronutrients and calories) during eight weeks of training. Each participant will complete testing before and after the intervention for assessment of body composition (lean tissue, fat, and bone mass), strength, central fatigue, markers of inflammation, and bone resorption. Over the 8-weeks of training, participants will train four-five days per week for 1-1.5 hours per session with exercises targeting all major muscle groups. The training will involve a "two day split" where different muscle groups are trained on two consecutive days (day 1 involves chest, back, and arms; day 2 legs, shoulders, and abdominals). Resistance training will provide the necessary stimulus for protein synthesis to optimize the effect of a protein-containing nutritional supplement. The hemp or soy powder will be consumed in two doses (i.e. 30 g powder containing 20 g protein per dose) immediately after exercise sessions and one hour after exercise. This dosing regimen is optimal for stimulating muscle protein synthesis and building muscle mass . On the one non-training day per week the two doses will be consumed with meals.


Eligibility criteria: Inclusion Criteria:

* At least 6 months experience with resistance training

Exclusion Criteria:

* Allergies to hemp or soy
* Consumption of other nutritional supplements in previous month
* Answered "yes" to questions on the Physical Activity Readiness Questionnaire

Primary outcomes:
measure: Change in lean tissue mass (kg)
timeFrame: 8 weeks
Secondary outcomes:
measure: Change in fat mass (kg)
timeFrame: 8 weeks
measure: Change in bone mass (grams)
timeFrame: 8 weeks
measure: Change in elbow flexor muscle thickness (cm)
timeFrame: 8 weeks
measure: Change in knee extensor muscle thickness (cm)
timeFrame: 8 weeks
measure: Change in bench press strength (kg)
timeFrame: 8 weeks
measure: Change in arm curl strength (kg)
timeFrame: 8 weeks
measure: Change in leg press strength (kg)
timeFrame: 8 weeks
measure: Change in inflammation by interleukin-6 (mmol/l) levels
timeFrame: 8 weeks
measure: Change in inflammation by C-reactive protein (mmol/l) levels
timeFrame: 8 weeks
measure: Change in bone resorption (N-telopeptides) (mmol/l)
timeFrame: 8 weeks
measure: Change in voluntary muscle activation (Nm)
timeFrame: 8 weeks
Other outcomes:
Locations:
city: Saskatoon
country: Canada
facility: University of Saskatchewan
state: Saskatchewan
Study officials:
affiliation: University of Saskatchewan
name: Philip Chilibeck
role: PRINCIPAL_INVESTIGATOR
References: