louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT01584726: Nebulized Magnesium Sulfate in Children With Moderate to Severe Asthma
Official title: Nebulized Magnesium Sulfate in Children With Moderate to Severe Asthma Exacerbation: A Randomized, Double-Blind, Controlled Trial (RCT)
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Asthma
Keywords: magnesium
nebulization
asthma
sulfate
children
pediatric
Lead sponsor: Hamad Medical Corporation
Sponsor class: INDUSTRY
First posted: 2012-04-25
Enrollment: 400
Sex: ALL
Minimum age (years): 2
Maximum age (years): 14
Standard ages: CHILD
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The purpose of this study is to investigate the use of magnesium sulfate nebulization in patient with moderate to severe asthma exacerbation in pediatric emergency.

Detailed description: the use of magnesium sulfate nebulization in patient with moderate to severe asthma exacerbation in pediatric emergency

follow asthma severity score and length of stay

Eligibility criteria: Inclusion Criteria:

* Pediatric asthma patients with moderate to severe exacerbation

Exclusion Criteria:

* Known allergy to magnesium sulfate
* History of neuromuscular disease, cardiac disease, renal disease, or underlying chronic lung disease
* Use of oral steroid medication within 72 hours of presentation
* Radiographic evidence of pneumonia at presentation
* Administration of intravenous magnesium sulfate prior to study enrollment

Primary outcomes:
measure: Would the use of nebulized magnesium sulfate in patients with moderate to severe asthma significantly reduce the time to clinical readiness for discharge?
timeFrame: 36 months
Secondary outcomes:
measure: • Would the use of nebulized magnesium sulfate in patients with moderate to severe asthma decrease admission and readmission rate, compared to placebo
timeFrame: 36 months
Other outcomes:
Locations:
city: Doha
country: Qatar
facility: Hamad Medical Corporation
city: Doha
country: Qatar
facility: Pediatric Emergency Centre
Study officials:
affiliation: SENIOR CONSULTANT-HEAD OF PEDIATRIC EMERGENCY
name: KHALID AL ANSARI, MD
role: PRINCIPAL_INVESTIGATOR
References:
citation: Alansari K, Ahmed W, Davidson BL, Alamri M, Zakaria I, Alrifaai M. Nebulized magnesium for moderate and severe pediatric asthma: A randomized trial. Pediatr Pulmonol. 2015 Dec;50(12):1191-9. doi: 10.1002/ppul.23158. Epub 2015 Feb 4.
Clinical trial NCT04585126: Effect of Cervical Block on Recurrent Laryngeal Nerve Monitoring During Thyroid Surgery
Official title: Effect of Ultrasound-guided Intermediate Cervical Block on Recurrent Laryngeal Nerve Monitoring During Thyroid Surgery : a Randomised Non-inferiority Study
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Thyroid Surgery
Keywords: thyroid surgery
cervical nerve block
recurrent laryngeal nerve monitoring
enhanced recovery after surgery
Lead sponsor: University Hospital, Caen
Sponsor class: OTHER
Collaborators: name: Centre Francois Baclesse
First posted: 2020-10-14
Enrollment: 120
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Intervention model description: Prospective, randomized, double blinded, non inferiority study comparing general anesthesia combined with cervical nerve block vs general anesthesia alone in thyroid surgery
Primary purpose: OTHER

Brief summary: Non-inferiority study aimed to assess the impact of cervical block on recurrent laryngeal nerve monitoring during thyroid surgery Secondary outcomes will assess post-operative recovery, post-operative pain and post-operative dysphonia


Eligibility criteria: Inclusion Criteria:

* Patients over 18, able to give consent after clear and fair information
* Affiliated to social security
* Total thyroidectomy performed in the context of Graves' disease in biological euthyroidism with the need for surgical treatment (pregnancy project, fluctuating TSH, etc.), or multiheteronodular goiter with suspect or compressive nodules, or lobo-isthmectomy
* No previous homolateral cervical surgery
* Professional activity
* Telephone line (at home or cellular)

Exclusion Criteria:

* Patients over 18 under legal protection
* Allergy to local anesthetics
* Existence of preoperative laryngeal dysphonia or paralysis
* Patient with a submerging goiter (lower edge of the thyroid not seen on the preoperative cervical ultrasound)
* Presence of uncontrolled infectious pathology
* Pregnant or breastfeeding woman or no contraception
* Lymph node dissection planned or patient at high risk of lymph node dissection (BETHESDA 5 and 6)

Primary outcomes:
measure: Effect on recurrent laryngeal nerve monitoring
timeFrame: Before surgical dissection
Secondary outcomes:
measure: Postoperative recovery
timeFrame: 7 days post surgery
measure: Postoperative pain
timeFrame: First 24 hours post surgery
measure: Early postoperative complications
timeFrame: First 24 hours post surgery
measure: Postoperative dysphonia
timeFrame: During the first 24 hours and 7 days post surgery
measure: Late postoperative complications
timeFrame: 1 to 3 months post surgery
Other outcomes:
Locations:
city: Caen
country: France
facility: Caen University Hospital
Study officials:
affiliation: University Hospital, Caen
name: Emmanuel Babin
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT06155526: Muscle Mechanical Response in Exercise.
Official title: Muscle Mechanical Response in Active vs. Passive Resting Exercise
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Muscle Weakness
Keywords: tensiomyography
triceps
dorsal
exercise
pectoral
Lead sponsor: Universidad Católica de Ávila
Sponsor class: OTHER
First posted: 2023-12-04
Enrollment: 90
Sex: MALE
Minimum age (years): 18
Maximum age (years): 25
Standard ages: ADULT
Observational model: CASE_CROSSOVER
Time perspective: CROSS_SECTIONAL
Sampling method: NON_PROBABILITY_SAMPLE
Study population: male swimmers from 18 to 25 years old with a minimum mark who swimming a croll style

Brief summary: The muscular response on the main muscles of the propulsive phase of the upper limb in crawl has been evaluated by tensiomyography (TMG), which was carried out through three parameters: activation time (Td), contraction time (Tc) and maximum deformation (Dm).

The objective of this study is to evaluate the hypothesis of changes produced between lactic resistance training with passive rest and lactic resistance training with active rest.

For this, thirty swimmers participated, with an average age of 20 years.


Eligibility criteria: Inclusion Criteria:

* Be between 18 and 25 years old.
* have a minimum mark or have participated by ranking in a crawl event in the territorial championship of Madrid in the current season belong.
* to the male gender.

Exclusion Criteria:

* subjects who did not meet the minimum age and did not obtain the minimum mark and did not sign the informed consent.

Primary outcomes:
measure: activation time
timeFrame: 15 minutes
measure: contraction time
timeFrame: 15 minutes
measure: maximum deformation
timeFrame: 15 minutes
Secondary outcomes:
Other outcomes:
Locations:
city: Ávila
country: Spain
facility: Jorge V Velázquez Saornil
state: Avila
Study officials:
References:
citation: Palma, S., Silva, H., Gamboa, H., & Mil-Homens, P. (2008). Standing Jump Loft Time Measurement - An Acceleration based Method. International Conference on Bio-inspired Systems and Signal Processing.
citation: Cular D, Babic M, Zubac D, Kezic A, Macan I, Peyre-Tartaruga LA, Ceccarini F, Padulo J. Tensiomyography: from muscle assessment to talent identification tool. Front Physiol. 2023 Jun 26;14:1163078. doi: 10.3389/fphys.2023.1163078. eCollection 2023.
citation: Gil S, Loturco I, Tricoli V, Ugrinowitsch C, Kobal R, Abad CC, Roschel H. Tensiomyography parameters and jumping and sprinting performance in Brazilian elite soccer players. Sports Biomech. 2015 Sep;14(3):340-50. doi: 10.1080/14763141.2015.1062128. Epub 2015 Aug 14.
citation: Maloney SJ, Fletcher IM. Lower limb stiffness testing in athletic performance: a critical review. Sports Biomech. 2021 Feb;20(1):109-130. doi: 10.1080/14763141.2018.1460395. Epub 2018 May 16.
citation: Douglas J, Pearson S, Ross A, McGuigan M. Reactive and eccentric strength contribute to stiffness regulation during maximum velocity sprinting in team sport athletes and highly trained sprinters. J Sports Sci. 2020 Jan;38(1):29-37. doi: 10.1080/02640414.2019.1678363. Epub 2019 Oct 19.
Clinical trial NCT06520826: Vafseo Outcomes In-Center Experience
Official title: Safety of Three Times Weekly Oral Vadadustat for the Treatment of Anemia in Hemodialysis Subjects: Vafseo Outcomes In-Center Experience
Study type: INTERVENTIONAL
Overall status: RECRUITING
Phase: PHASE3
Conditions: Anemia of Chronic Kidney Disease
Lead sponsor: USRC Kidney Research
Sponsor class: NETWORK
Collaborators: name: Akebia Therapeutics
First posted: 2024-07-25
Enrollment: 2200
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: This trial is an investigator-initiated, multi-center, randomized (1:1), open-label, active-controlled, pragmatic study of the safety of vadadustat administered three times per week for the treatment of anemia in in-center hemodialysis patients with End Stage Kidney Disease (ESKD). This study will obtain long-term safety data in a large sample of subjects receiving in-center hemodialysis to support adoption of three times per week vadadustat dosing.


Eligibility criteria: Inclusion Criteria:

* Adult patients greater than or equal to 18 years of age.
* Receiving outpatient in-center hemodialysis at least three times per week for end-stage kidney disease.
* Currently prescribed or eligible for erythropoiesis-stimulating agent based on approved facility policy
* Understands the procedures and requirements of the study and provides written informed consent and authorization for protected health information disclosure.

Exclusion Criteria:

* Contraindication to receive vadadustat or any of its known constituents per USPI.
* Cirrhosis or active, acute liver disease. Concomitant use of any hypoxia-inducible factor prolyl-hydroxylases or OAT1/OAT3 inhibitors (probenacid, rifampicin, gemfibrozil, or teriflunomide).
* Unable to comply with study requirements or in the opinion of a healthcare provider or a member of the central study team, not clinically stable to participate in the study.
* Pregnant at time of consent (per subject self-report).

Primary outcomes:
measure: All-cause mortality
timeFrame: 18 months
Secondary outcomes:
measure: All-cause hospitalization
timeFrame: 18 months
Other outcomes:
Locations:
city: Lone Tree
country: United States
facility: USRC Kidney Research
state: Colorado
city: Dalton
country: United States
facility: Nephrology and Hypertension Specialists, PC
state: Georgia
city: Gallup
country: United States
facility: US Renal Care - Gallup
state: New Mexico
city: Dallas
country: United States
facility: Dallas Renal Group
state: Texas
city: Live Oak
country: United States
facility: US Renal Care - Live Oak
state: Texas
Study officials:
References:
Clinical trial NCT00934726: Non-interventional Open Label Study to Investigate the Effect of Quetiapine XR on Patient Satisfaction and Quality of Life in Patients With Schizophrenia
Official title: Patient Satisfaction and Quality of Life Under Treatment With Seroquel XR
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Quality of Life in Schizophrenia
Keywords: Quality of Life
Patient satisfaction
Schizophrenia
Investigate quality of life in schizophrenia
Lead sponsor: AstraZeneca
Sponsor class: INDUSTRY
First posted: 2009-07-08
Enrollment: 150
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: The psychiatrists according to inclusion criteria select patients.

Brief summary: Since subjective well-being and quality of life (QoL) are increasingly being recognized as important treatment outcomes in patients with schizophrenia (Hofer et al., 2004; Becker et al., 2005), the aim of this study is to investigate the effect of treatment with quetiapine XR on these parameters in the acute hospital and the subsequent ambulant care setting. The study is planned to be conducted in 15 centers all over Austria and, overall, about 150 inpatients with a ICD-10 diagnosis of acute schizophrenia are planning to be enrolled. The duration of the whole trial will be approximately 4 months, whereas 2 visits during hospitalization and two further visits after discharge will be scheduled. At each visit, adverse events and safety parameters, patient satisfaction and effectiveness of the current treatment, as well as concomitant medication and dosing schedules will be assessed and documented.In addition to that, the patients' overall satisfaction with antipsychotic therapy and their current quality of life will be determined using a QoL questionnaire, focussing on the subjective experience with quetiapine XR.


Eligibility criteria: Inclusion Criteria:

* Adult schizophrenia patients
* Inclusion according to Summary of product characteristics

Exclusion Criteria:

* Diagnosis other than schizophrenia
* Patients for which Seroquel XR is not registered (pregnant women, children and adolescents...)

Primary outcomes:
measure: Subject wellbeing under Neuroleptics scale (Quality of Life)
timeFrame: 4 months
Secondary outcomes:
measure: BPRS (Brief Psychiatric Rating Scale)
timeFrame: 4 months
measure: CGI (Clinical Global Impression)
timeFrame: 4 months
measure: All adverse events occurring during the study will be documented
timeFrame: 4 months
Other outcomes:
Locations:
Study officials:
affiliation: AKH Vienna
name: Siegfried Kasper, Prof.
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT00631826: Shoulder Rotational Flexibility and Throwing Arm Injuries of Baseball Pitchers
Official title: Shoulder Internal/External Rotational Flexibility is Related to Throwing Arm Injuries in Professional Baseball Players
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Shoulder Injuries
Shoulder Flexibility
Rotational Resistance of Shoulder
Keywords: Shoulder
Injuries
Flexiblity
Rotational resistance
Lead sponsor: University of Florida
Sponsor class: OTHER
Collaborators: name: Major League Baseball
First posted: 2008-03-10
Enrollment: 40
Sex: MALE
Minimum age (years): 18
Maximum age (years): 40
Standard ages: ADULT
Accepts healthy volunteers: no
Observational model: CASE_ONLY
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Collegiate level baseball pitchers

Brief summary: The evaluation of any relationship between the rotational resistance of the shoulder and shoulder flexibility with throwing arm injuries in professional and college level pitchers.


Eligibility criteria: Inclusion Criteria:

* Currently competing
* Healthy pitching arm

Exclusion Criteria:

* Inactive status
* Previous injury

Primary outcomes:
Secondary outcomes:
Other outcomes:
Locations:
city: Gainesville
country: United States
facility: UF&Shands Orthopaedics and Sports Medicine Institute
state: Florida
Study officials:
affiliation: UF Department of Orthopaedics and Rehabilitation
name: Nigel Zheng, PhD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT00146926: Comparison of Three Different Strategies to Prevent Propofol Induced Pain During Infusion
Official title: Comparison of Three Different Strategies to Prevent Propofol Induced Pain During Infusion
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: PHASE3
Conditions: Induction of Total Intravenous General Anesthesia
Keywords: Propofol
pain
general anesthesia
prevention
Lead sponsor: Hospices Civils de Lyon
Sponsor class: OTHER
First posted: 2005-09-07
Enrollment: 200
Sex: ALL
Minimum age (years): 18
Maximum age (years): 75
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL

Brief summary: Propofol is a popular intravenous drug to induce anesthesia but it causes local pain with an incidence between 40 and 90%. Three different strategies to prevent propofol induced pain will be studied compared with placebo. Pain will be scored with a four-point scale.


Eligibility criteria: Inclusion Criteria:

Healthy adults (ASA 1-2) for scheduled surgery under general anesthesia with propofol

Exclusion Criteria:

* pregnant
* sedative or analgesic drug 24h before surgery
* allergy with drug used in the study
* difficulty of communication
* absence of informed written consent

Primary outcomes:
measure: After prophylactic solution, evaluation of the pain caused by injection of propofol with a four-point scale before lose of consciousness
Secondary outcomes:
measure: Explicite and implicite memory of pain immediately after surgery and on day one
measure: Adverse effects
Other outcomes:
Locations:
city: Lyon
country: France
facility: Grégoire CHATAIN
Study officials:
affiliation: Hospices Civils de Lyon
name: Vincent PIRIOU, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT06571526: External Focus Strategy on Visuomotor Control in Older Adults
Official title: Investigating Visual Search Strategies and the Role of Attentional Focus During Psychomotor Gait Re-education in Older Adults at Risk of Falling: Implication for Fall Rehabilitation
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Gait
Fall Risk
Older Adults
Keywords: attentional focus
gait
older adults
visual search
Lead sponsor: The Hong Kong Polytechnic University
Sponsor class: OTHER
First posted: 2024-08-26
Enrollment: 112
Sex: ALL
Minimum age (years): 65
Standard ages: OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: Only a few studies have adopted external focus strategy as an intervention to mitigate the negative effects of heightened conscious movement processing in older adults. The goal was to investigate whether a single-session intervention (SSI) using external focus strategy could improve gait stability and visual search behaviors during adaptive locomotion among the older population.

Participants were randomly allocated to either an external focus (EXT) or a control group (CON). All participants performed an obstacle circumvention walking task along an 8-m walkway for five trials at pre-intervention (T0), post-intervention (T1), and retention (T2). The training phase included 20 walking trials. EXT focused on digits displayed on monitors at their path destinations, while CON walked naturally without any manipulation.


Eligibility criteria: Inclusion Criteria:

* aged 65 or above
* were able to walk independently indoors without walking aids

Exclusion Criteria:

* a total score of less than 24 on the Chinese version of the Mini-Mental State Examination
* a static visual acuity poorer than 20/40 vision
* the presence of any untreated cerebral vascular disease, Parkinson\&#39;s disease, or any other major neurological deficit

Primary outcomes:
measure: Gait stability
timeFrame: pre-test, post-test (the same day, immediately after the single-session intervention), 1 week after post-test (retention)
measure: Visual search behavior
timeFrame: pre-test, post-test (the same day, immediately after the single-session intervention), 1 week after post-test (retention)
Secondary outcomes:
Other outcomes:
Locations:
city: Hong Kong
country: Hong Kong
facility: The Hong Kong Polytechnic University
Study officials:
References:
Clinical trial NCT02199626: SECOND GENERATION COLON CAPSULE ENDOSCOPY (CCE-2) IN PEDIATRIC CROHN'S DISEASE (CD).
Official title: SECOND GENERATION COLON CAPSULE ENDOSCOPY (CCE-2) IN PEDIATRIC CROHN'S DISEASE (CD).
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE4
Conditions: Pediatric
Colon Capsule Endoscopy
Lead sponsor: Azienda Policlinico Umberto I
Sponsor class: OTHER
First posted: 2014-07-24
Enrollment: 40
Sex: ALL
Minimum age (years): 6
Maximum age (years): 18
Standard ages: CHILD
ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: DIAGNOSTIC

Brief summary: This prospective pilot study of 40 pediatric patients with Crohn's Disease, that are candidates for endoscopic and imaging re-evaluation, examines the Given Diagnostic System and the second generation of colon capsule in comparison second generation of colon capsule endoscopy (CCE-2) to magnetic resonance enterography (MRE), small intestine contrast ultrasonography (SICUS) and endoscopy (upper and lower).

This study aims

1. To evaluate and compare the accuracy of CCE-2 with MRE, SICUS and endoscopy in the evaluation of pediatric Crohn's disease.
2. To evaluate the safety of CCE-2 in pediatric CD.


Eligibility criteria: Ages Eligible for Study: 6-18 Years Genders Eligible for Study: Both Accepts Healthy Volunteers: No

Inclusion criteria:

Subjects must meet one the following inclusion criteria to be eligible for enrollment into this proposed study:

* diagnosis of Crohn's Disease made at least 3 months before the enrolment;
* subject was referred for endoscopic and imaging follow-up in Crohn's Disease
* signed informed consent.

Exclusion criteria

The presence of any of the following will exclude a subject from study enrollment:

* Subject has dysphagia
* Subject has renal insufficiency
* Subject is known structuring Crohn's Disease identified by magnetic resonance enterography (MRE) or small intestine contrast ultrasonography (SICUS).
* Subject has had prior abdominal surgery of the gastrointestinal tract other than uncomplicated procedures that would be unlikely to lead to bowel obstruction based on the magnetic resonance enterography findings and clinical judgment of the investigator.

Primary outcomes:
measure: To evaluate and compare the accuracy of Second generation of Colon Capsule Endoscopy with magnetic resonance enterography, small intestine contrast ultrasonography and endoscopy in the evaluation of pediatric Crohn's disease.
timeFrame: 3 days
Secondary outcomes:
measure: To evaluate the safety of second generation of colon capsule endoscopy in pediatric Crohn's disease.
timeFrame: two days
Other outcomes:
Locations:
city: Rome
country: Italy
facility: Pediatric Gastroenterology and Liver Unit, Sapienza - University of Rome
Study officials:
References:
citation: Oliva S, Cucchiara S, Civitelli F, Casciani E, Di Nardo G, Hassan C, Papoff P, Cohen SA. Colon capsule endoscopy compared with other modalities in the evaluation of pediatric Crohn's disease of the small bowel and colon. Gastrointest Endosc. 2016 May;83(5):975-83. doi: 10.1016/j.gie.2015.08.070. Epub 2015 Sep 9.