Clinical trial NCT04813263: Study of Oral Venetoclax Tablets to Evaluate Adverse Events and Change in Disease Activity in Participants of Any Age With Acute Myeloid Leukemia
Official title: A Post-marketing Observational Study for Venetoclax in Patients Diagnosed With Acute Myeloid Leukemia in Japan
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Acute Myeloid Leukemia (AML)
Keywords: Acute Myeloid Leukemia (AML)
Cancer
Venetoclax
Venclexta
Venclyxto
Lead sponsor: AbbVie
Sponsor class: INDUSTRY
First posted: 2021-03-24
Enrollment: 424
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Participants who are prescribed venetoclax for the treatment of Acute Myeloid Leukemia (AML) in routine clinical practice across Japan.

Brief summary: Acute Myeloid Leukemia (AML) is an aggressive and rare cancer of myeloid cells (a white blood cell responsible for fighting infections) and is the most common acute leukemia in adults. This study will assess how safe and effective oral venetoclax is in participants with AML. Adverse events and change in disease activity will be monitored under routine clinical practice.

Venetoclax is an approved drug to treat Acute Myeloid Leukemia (AML). Around 400 participants of any age who are treated with oral venetoclax tablets for AML in accordance with the approved label will be enrolled in the study across Japan.

Participants will be followed up to 52 weeks following the first dose of oral venetoclax tablets.

There is expected to be no additional burden for participants in this study. Data will be collected by information provided by participating physicians based on routine medical records.


Eligibility criteria: Inclusion Criteria:

- All participants who are administered venetoclax for treatment of AML.

Exclusion Criteria:

None

Primary outcomes:
measure: Percentage of Participants With ≥ Grade 3 Neutropenia of Venetoclax Regimens With Unfit Acute Myeloid Leukemia (AML)
timeFrame: Up to 52 weeks.
Secondary outcomes:
measure: Percentage of Participants With Febrile Neutropenia and Thrombocytopenia
timeFrame: Up to 52 weeks
measure: Percentage of Participants With Tumor Lysis Syndrome (TLS)
timeFrame: Up to 52 weeks
measure: Percentage of Participants Reported >= Grade 3 Adverse Events (AE)/Adverse Drug Reactions (ADR)
timeFrame: Up to 52 weeks
measure: Percentage of Participants Reported Adverse Events (AE)/Adverse Drug Reaction (ADR)
timeFrame: Up to 52 weeks
measure: Percentage of Participants With AE/ADR When Used Concomitantly With CYP3A Inhibitors or Growth Colony Stimulating Factor (G-CSF)
timeFrame: Up to 52 weeks
measure: Percentage of Participants With Composite Complete Remission Rate (CR + CRi)
timeFrame: Up to 52 weeks
measure: Median Time to Best Response
timeFrame: Up to 52 weeks.
measure: Median Treatment Duration
timeFrame: Up to 52 weeks
measure: Median Overall Survival
timeFrame: Up to 52 weeks
measure: Median Duration of Composite Complete Remission
timeFrame: Up to 52 weeks
Other outcomes:
Locations:
city: Anjo-shi
country: Japan
facility: Anjou Kousei Hospital /ID# 244213
state: Aichi
city: Nagoya shi
country: Japan
facility: Nagoya City University Hospital /ID# 256177
state: Aichi
city: Nagoya-shi
country: Japan
facility: Nagoya City West Medical Center /ID# 250844
state: Aichi
city: Nagoya-shi
country: Japan
facility: Aichi Cancer Center Hospital /ID# 243785
state: Aichi
city: Nagoya-shi
country: Japan
facility: Japanese Red Cross Aichi Medical Center Nagoya Daini Hospital /ID# 242173
state: Aichi
city: Nagoya-shi
country: Japan
facility: Nagoya University Hospital /ID# 246009
state: Aichi
city: Obu-shi
country: Japan
facility: National Center for Geriatrics and Gerontology /ID# 251683
state: Aichi
city: Toyohashi-shi
country: Japan
facility: Toyohashi Municipal Hospital /ID# 243784
state: Aichi
city: Toyokawa-shi
country: Japan
facility: Toyokawa City Hospital /ID# 242707
state: Aichi
city: Toyota-shi
country: Japan
facility: Toyota Memorial Hospital /ID# 242175
state: Aichi
city: Akita-shi
country: Japan
facility: Akita city Hospital /ID# 240008
state: Akita
city: Odate-shi
country: Japan
facility: Odate Municipal General Hospital /ID# 258238
state: Akita
city: Aomori-shi
country: Japan
facility: Aomori Prefectural Central Hospital /ID# 249442
state: Aomori
city: Hirosaki-shi
country: Japan
facility: National Hospital Organization Hirosaki General Medical Center /ID# 246008
state: Aomori
city: Asahi-shi
country: Japan
facility: Asahi General Hospital /ID# 233889
state: Chiba
city: Chiba-shi
country: Japan
facility: Chiba Aoba Municipal Hospital /ID# 240565
state: Chiba
city: Chiba-shi
country: Japan
facility: Chiba University Hospital /ID# 246011
state: Chiba
city: Chiba-shi
country: Japan
facility: Duplicate_Chiba Cancer Center /ID# 248122
state: Chiba
city: Ichihara City
country: Japan
facility: KK Clinic Ichihara /ID# 250859
state: Chiba
city: Ichihara-shi
country: Japan
facility: Chiba Rosai Hospital /ID# 238767
state: Chiba
city: Ichikawa-shi
country: Japan
facility: Tokyo Dental College Ichikawa General Hospital /ID# 262626
state: Chiba
city: Inzai-shi
country: Japan
facility: Nippon Medical Chiba Hokusoh Hospital /ID# 250297
state: Chiba
city: Kamogawa-shi
country: Japan
facility: Kameda General Hospital /ID# 241877
state: Chiba
city: Kashiwa-shi
country: Japan
facility: The Jikei University Kashiwa Hospital /ID# 259510
state: Chiba
city: Kashiwa-shi
country: Japan
facility: National Cancer Center Hospital East /ID# 241917
state: Chiba
city: Kisarazu-shi
country: Japan
facility: Kimitsu Chuo Hospital /ID# 248776
state: Chiba
city: Matsudo-shi
country: Japan
facility: Chiba West General Hospital /ID# 262918
state: Chiba
city: Narashino-shi
country: Japan
facility: Tsudanuma Central General Hospital /ID# 245890
state: Chiba
city: Narita-shi
country: Japan
facility: Japanese Red Cross Narita Hospital /ID# 243775
state: Chiba
city: Narita-shi
country: Japan
facility: IUHW Narita Hospital /ID# 240574
state: Chiba
city: Narshino-shi
country: Japan
facility: Chibaken Saiseikai Narashino Hospital /ID# 254491
state: Chiba
city: Sakura-shi
country: Japan
facility: Toho University Sakura Medical Center /ID# 252187
state: Chiba
city: Matsuyama City
country: Japan
facility: Watanabe Hospital /ID# 254476
state: Ehime
city: Matsuyama-shi
country: Japan
facility: Ehime Prefectural Central Hospital /ID# 261348
state: Ehime
city: Matsuyama-shi
country: Japan
facility: Matsuyama Shimin Hospital /ID# 243050
state: Ehime
city: Matsuyama-shi
country: Japan
facility: National Hospital Organization Shikoku Cancer Center /ID# 242171
state: Ehime
city: Toon-shi
country: Japan
facility: Ehime University Hospital /ID# 244207
state: Ehime
city: Fukui-shi
country: Japan
facility: Fukuiken Saiseikai Hospital /ID# 245062
state: Fukui
city: Fukui-shi
country: Japan
facility: Fukuiken Saiseikai Hospital /ID# 246005
state: Fukui
city: Fukuoka shi
country: Japan
facility: National Hospital Organization Kyushu Medical Center /ID# 242026
state: Fukuoka
city: Fukuoka-shi
country: Japan
facility: Saiseikai Fukuoka Genaral Hospital /ID# 255193
state: Fukuoka
city: Fukuoka-shi
country: Japan
facility: Fukuoka Wajiro Hospital /ID# 238755
state: Fukuoka
city: Fukuoka-shi
country: Japan
facility: National Hospital Organization Kyushu Cancer Center /ID# 244217
state: Fukuoka
city: Fukuoka-shi
country: Japan
facility: Kyushu University Hospital /ID# 248781
state: Fukuoka
city: Fukuoka-shi
country: Japan
facility: Fukuoka University Hospital /ID# 244214
state: Fukuoka
city: Fukuoka-shi
country: Japan
facility: Japanese Red Cross Fukuoka Hospital /ID# 241181
state: Fukuoka
city: Fukuoka-shi
country: Japan
facility: Murakami Karindoh Hospital /ID# 256179
state: Fukuoka
city: Iizuka
country: Japan
facility: Aso Iizuka Hospital /ID# 266806
state: Fukuoka
city: Kitakyusyu-shi
country: Japan
facility: NHO Kokura Medical Center /ID# 257008
state: Fukuoka
city: Kitakyusyu-shi
country: Japan
facility: Wakamatsu Hospital /ID# 251728
state: Fukuoka
city: Kurume City
country: Japan
facility: Shinkoga Hospital /ID# 248786
state: Fukuoka
city: Kurume-shi
country: Japan
facility: Kurume University Hospital /ID# 240885
state: Fukuoka
city: Kurume-shi
country: Japan
facility: St. Mary's Hospital /ID# 242332
state: Fukuoka
city: Omuta-shi
country: Japan
facility: Omuta City Hospital /ID# 246823
state: Fukuoka
city: Yanagawa-shi
country: Japan
facility: Nagata Hospital /ID# 256180
state: Fukuoka
city: Date-shi
country: Japan
facility: Kita Fukushima Medical Center /ID# 250296
state: Fukushima
city: Fukushima-shi
country: Japan
facility: Fukushima Minami Cardiovascular Hospital /ID# 252216
state: Fukushima
city: Iwaki-shi
country: Japan
facility: Tokiwakai Jyoban Hospital /ID# 257007
state: Fukushima
city: Iwaki-shi
country: Japan
facility: Iwaki Kyoritsu General Hospital /ID# 260209
state: Fukushima
city: Koriyama-shi
country: Japan
facility: Ohta Nishinouchi Hospital /ID# 243052
state: Fukushima
city: Shirakawa-shi
country: Japan
facility: Shirakawa Kosei General Hosp. /ID# 245815
state: Fukushima
city: Gifu-shi
country: Japan
facility: Gifu Municipal Hospital /ID# 241156
state: Gifu
city: Gifu-shi
country: Japan
facility: Gifu University Hospital /ID# 241183
state: Gifu
city: Gifu-shi
country: Japan
facility: Gifu Red Cross Hospital /ID# 240562
state: Gifu
city: Ogaki-shi
country: Japan
facility: Ogaki Municipal Hospital /ID# 239353
state: Gifu
city: 高山市
country: Japan
facility: Japanese Red Cross Takayama Hospital /ID# 240568
state: Gifu
city: Fujioka-shi
country: Japan
facility: Fujioka General Hospital /ID# 255196
state: Gunma
city: Maebashi-shi
country: Japan
facility: Gunmaken Saiseikai Maebashi Hospital /ID# 239383
state: Gunma
city: Ota-shi
country: Japan
facility: Gunma Prefectural Cancer Center /ID# 242177
state: Gunma
city: Shibukawa-shi
country: Japan
facility: National Hospital Organization Shibukawa Medical Center /ID# 245026
state: Gunma
city: Tatebayashi-shi
country: Japan
facility: Tatebayashi Kosei General Hospital /ID# 252188
state: Gunma
city: Hiroshima-shi
country: Japan
facility: Hiroshima Red Cross Hospital & Atomic-bomb Survivors Hospital /ID# 240880
state: Hiroshima
city: Mihara
country: Japan
facility: Mihara Shiromachi Hospital /ID# 246754
state: Hiroshima
city: Otake-shi
country: Japan
facility: NHO Hiroshima-Nishi Medical center /ID# 238766
state: Hiroshima
city: Kitami-shi
country: Japan
facility: Kitami Red Cross Hospital /ID# 251065
state: Hokkaido
city: Muroran-shi
country: Japan
facility: Steel Memorial Muroran Hospita /ID# 231383
state: Hokkaido
city: Obihiro-shi
country: Japan
facility: Obihiro kosei Hospital /ID# 252218
state: Hokkaido
city: Sapporo-shi
country: Japan
facility: Sapporo Hokuyu Hospital /ID# 250856
state: Hokkaido
city: Sapporo-shi
country: Japan
facility: Hokkaido Cancer Center /ID# 249441
state: Hokkaido
city: Sapporo-shi
country: Japan
facility: Sapporo Hokushin Hospital /ID# 241878
state: Hokkaido
city: Sapporo-shi
country: Japan
facility: Hokkaido P.W.F.A.C. Sapporo-Kosei General Hospital /ID# 249446
state: Hokkaido
city: Sapporo-shi
country: Japan
facility: Sapporo Medical University Hospital /ID# 252217
state: Hokkaido
city: Sapporo-shi
country: Japan
facility: Hokkaido University Hospital /ID# 244223
state: Hokkaido
city: Sapporo-shi
country: Japan
facility: Aiiku Hospital /ID# 239047
state: Hokkaido
city: Sapporo
country: Japan
facility: Homecareclinicn-Consept /Id# 239377
state: Hokkaido
city: Sapporo
country: Japan
facility: Tenshi Hospital /ID# 243051
state: Hokkaido
city: Sunagawa
country: Japan
facility: Sunagawa City Medical Center /ID# 239382
state: Hokkaido
city: Wakkanai City
country: Japan
facility: Wakkanai City Hospital /ID# 243782
state: Hokkaido
city: 札幌市
country: Japan
facility: Sapporo Kiyota Hospital /ID# 231385
state: Hokkaido
city: Ako-shi
country: Japan
facility: Ako Central Hospital /ID# 239721
state: Hyogo
city: Amagasaki-shi
country: Japan
facility: Hyogo Prefectural Amagasaki General Medical Center /ID# 239355
state: Hyogo
city: Itami-shi
country: Japan
facility: Itami City Hospital /ID# 233888
state: Hyogo
city: Kobe-shi
country: Japan
facility: Hyogo Prefectural Kobe Children's Hospital /ID# 245817
state: Hyogo
city: Kobe-shi
country: Japan
facility: Kobe City Medical Center General Hospital /ID# 246010
state: Hyogo
city: Kobe-shi
country: Japan
facility: Shinko Hospital /ID# 233782
state: Hyogo
city: Kobe-shi
country: Japan
facility: Konan Medical Center /ID# 246079
state: Hyogo
city: Nishinomiya-shi
country: Japan
facility: Hyogo?Prefectural?Nishinomiya Hospital /ID# 239354
state: Hyogo
city: Nishinomiya-shi
country: Japan
facility: Hyogo Medical University Hospital /ID# 240569
state: Hyogo
city: Ono-shi
country: Japan
facility: Kita-harima Medical Center /ID# 254490
state: Hyogo
city: Tamba-shi
country: Japan
facility: Hyogo Prefectural Tamba Medical Center /ID# 240884
state: Hyogo
city: Tanbasasayama-shi
country: Japan
facility: Hyogo College of Medicine Sasayama Medical Center /ID# 240888
state: Hyogo
city: 洲本市
country: Japan
facility: Hyogo Prefectural Awaji Medical Center /ID# 240823
state: Hyogo
city: Higashi Ibaraki-gun
country: Japan
facility: National Hospital Organization Mito Medical Center /ID# 239719
state: Ibaraki
city: Hitachi-shi
country: Japan
facility: Hitachi General Hospital /ID# 239376
state: Ibaraki
city: Toride-shi
country: Japan
facility: JA Toride Medical Center /ID# 240573
state: Ibaraki
city: Tsukuba-shi
country: Japan
facility: University of Tsukuba Hospital /ID# 242023
state: Ibaraki
city: Kanazawa-Shi
country: Japan
facility: JCHO Kanazawa Hospital /ID# 239379
state: Ishikawa
city: Oshu-shi
country: Japan
facility: Iwate Prefectural Isawa Hospital /ID# 246819
state: Iwate
city: Shiwa-gun
country: Japan
facility: Iwate Medical University Hospital /ID# 251009
state: Iwate
city: Sakaide City
country: Japan
facility: Sakaide City Hospital /ID# 240563
state: Kagawa
city: Kagoshima-shi
country: Japan
facility: Imakiire General Hospital /ID# 258237
state: Kagoshima
city: Kagoshima-shi
country: Japan
facility: Imamura General Hospital /ID# 234006
state: Kagoshima
city: Kanoya-shi
country: Japan
facility: Medical Corporation Seijinkai Ikeda Hospital /ID# 242174
state: Kagoshima
city: CHIGASAKI-shi
country: Japan
facility: Shonan Tobu Sogo Hospital /ID# 241913
state: Kanagawa
city: Kamakura-shi
country: Japan
facility: Shonan Kamakura General Hospital /ID# 243053
state: Kanagawa
city: Kawasaki-shi
country: Japan
facility: Kawasaki Municipal Hospital /ID# 241162
state: Kanagawa
city: Kawasaki-shi
country: Japan
facility: Japan Organization of Occupational Health and Society Kanto Rosai Hospital /ID# 255195
state: Kanagawa
city: Kawasaki-shi
country: Japan
facility: Toranomon Hospital Kajigaya /ID# 256186
state: Kanagawa
city: Kawasaki
country: Japan
facility: Teikyo University Mizonokuchi Hospital /ID# 244842
state: Kanagawa
city: Yokohama shi
country: Japan
facility: Yokohama City University Medical Center /ID# 248777
state: Kanagawa
city: Yokohama-shi
country: Japan
facility: Saiseikai Yokohamashi Nanbu Hospital /ID# 247955
state: Kanagawa
city: Yokohama-shi
country: Japan
facility: Kanagawa Cancer Center /ID# 246822
state: Kanagawa
city: Yokohama
country: Japan
facility: St. Marianna University School of Medicine Yokohama City Seibu Hospital /ID# 266803
state: Kanagawa
city: 高知市
country: Japan
facility: Kochi Health Sciences Center /ID# 241182
state: Kochi
city: Kumamoto shi
country: Japan
facility: Kumamoto University Hospital /ID# 239720
state: Kumamoto
city: Kumamoto-shi,Kumamoto
country: Japan
facility: Kumamoto City Hospital /ID# 254494
state: Kumamoto
city: Kumamoto-shi
country: Japan
facility: National Hospital Organization Kumamoto Medical Center /ID# 240886
state: Kumamoto
city: Kumamoto-shi
country: Japan
facility: Kumamoto Shinto General Hospital /ID# 242176
state: Kumamoto
city: Tamana-shi
country: Japan
facility: Kumamoto Kenhoku Hospital /ID# 258240
state: Kumamoto
city: Uki
country: Japan
facility: Kumamoto Minami National Hospital /ID# 242169
state: Kumamoto
city: Yatsushiro City
country: Japan
facility: JCHO Kumamoto General Hospital /ID# 248779
state: Kumamoto
city: Kyoto-shi
country: Japan
facility: University Hospital Kyoto Prefectural University of Medicine /ID# 244843
state: Kyoto
city: Kyoto-shi
country: Japan
facility: JCHO Kyoto Kuramaguchi Medical /ID# 248775
state: Kyoto
city: Kyoto-shi
country: Japan
facility: Japanese Red Cross Kyoto Daiichi Hosital /ID# 248124
state: Kyoto
city: Kyoto-shi
country: Japan
facility: Kyoto University Hospital /ID# 244844
state: Kyoto
city: Kyoto-shi
country: Japan
facility: National Hospital Organization Kyoto Medical Center /ID# 239092
state: Kyoto
city: Uji-shi
country: Japan
facility: Uji Tokushukai Medical Center /ID# 241876
state: Kyoto
city: 津市
country: Japan
facility: Takeuchi Hospital /ID# 238750
state: Mie
city: Natori-shi
country: Japan
facility: Miyagi Cancer Center /ID# 241879
state: Miyagi
city: Osaki-shi
country: Japan
facility: Osaki Citizen Hospital /ID# 249447
state: Miyagi
city: Sendai-shi
country: Japan
facility: Miyagi Chuo Hospital /ID# 259511
state: Miyagi
city: Sendai-shi
country: Japan
facility: Tohoku University Hospital /ID# 243757
state: Miyagi
city: Sendai-shi
country: Japan
facility: National Hospital Organization Sendai Medical Center /ID# 239384
state: Miyagi
city: Miyazaki-shi
country: Japan
facility: Miyazaki Prefectural Miyazaki Hospital /ID# 251730
state: Miyazaki
city: Miyazaki-shi
country: Japan
facility: Koga General Hospital /ID# 248120
state: Miyazaki
city: Miyazaki-shi
country: Japan
facility: University of Miyazaki Hospital /ID# 248805
state: Miyazaki
city: Nabeoka-shi
country: Japan
facility: Miyazaki Prefectural Nobeoka Hospital /ID# 248715
state: Miyazaki
city: Goto-shi
country: Japan
facility: Nagasaki Goto Chuoh Hospital /ID# 239723
state: Nagasaki
city: Nagasaki-shi
country: Japan
facility: Jap Red Cross Nagasaki Genbaku /ID# 245029
state: Nagasaki
city: Nagasaki-shi
country: Japan
facility: Nagasaki University Hospital /ID# 245028
state: Nagasaki
city: Omura-shi
country: Japan
facility: NHO Nagasaki Medical Center /ID# 240571
state: Nagasaki
city: Sasebo-shi
country: Japan
facility: Sasebo City General Hospital /ID# 238759
state: Nagasaki
city: Ikoma-shi
country: Japan
facility: Nara Hospital Kinki University Faculty of Medicine, /ID# 250295
state: Nara
city: Kashihara-shi
country: Japan
facility: Nara Medical University Hospital /ID# 251726
state: Nara
city: Nara-shi
country: Japan
facility: Nara Prefecture General Medical Center /ID# 254492
state: Nara
city: Tenri-shi
country: Japan
facility: Tenri Hospital /ID# 250855
state: Nara
city: Niigata-shi
country: Japan
facility: Niigata University Medical & Dental Hospital /ID# 245027
state: Niigata
city: Beppu-shi
country: Japan
facility: National Hospital Organization Beppu Medical Center /ID# 247894
state: Oita
city: Beppu-shi
country: Japan
facility: Kyushu University Beppu Hospital /ID# 249444
state: Oita
city: Oita City
country: Japan
facility: Almeida Memorial Hospital /ID# 241916
state: Oita
city: Oita-shi
country: Japan
facility: Oita Memorial Hospital /ID# 246818
state: Oita
city: Oita-shi
country: Japan
facility: Oita Prefectural Hospital /ID# 243786
state: Oita
city: Yufu City
country: Japan
facility: Oita University Hospital /ID# 261976
state: Oita
city: Kurashiki-shi
country: Japan
facility: Kawasaki Medical School Hospital /ID# 242709
state: Okayama
city: Kurashiki-shi
country: Japan
facility: Kurashiki Central Hospital /ID# 244205
state: Okayama
city: Maniwa
country: Japan
facility: Kaneda Hospital /ID# 238757
state: Okayama
city: Okayama-shi
country: Japan
facility: Duplicate_Okayama University Hospital /ID# 240887
state: Okayama
city: Okayama-shi
country: Japan
facility: Duplicate_Okayama University Hospital /ID# 243755
state: Okayama
city: Okayama-shi
country: Japan
facility: Japanese Red Cross Okayama Hospital /ID# 240879
state: Okayama
city: Okayama-shi
country: Japan
facility: Okayama Medical Center /ID# 243759
state: Okayama
city: Naha
country: Japan
facility: Naha City Hospital /ID# 242027
state: Okinawa
city: Nakagami-gun
country: Japan
facility: University of the Ryukyus Hospital /ID# 246821
state: Okinawa
city: Okinawa-shi
country: Japan
facility: Nakagami Hospital /ID# 243787
state: Okinawa
city: Habikino-shi
country: Japan
facility: Shiroyama Hospital /ID# 246762
state: Osaka
city: Hirakata-shi
country: Japan
facility: Kansai Medical University Hospital /ID# 246820
state: Osaka
city: Izumi-shi
country: Japan
facility: Izumi City General Hospital /ID# 253204
state: Osaka
city: Izumi-Shi
country: Japan
facility: Osaka Women's and Children's Hospital /ID# 266805
state: Osaka
city: Kishiwada-shi
country: Japan
facility: Kishiwada City Hospital /ID# 234002
state: Osaka
city: Kita-ku
country: Japan
facility: Sumitomo Hospital /ID# 243774
state: Osaka
city: Neyagawa City
country: Japan
facility: Seijukai Hospital /ID# 248788
state: Osaka
city: Osaka-shi
country: Japan
facility: Osaka Saiseikai Nakatsu Hospital /ID# 244209
state: Osaka
city: Osaka-shi
country: Japan
facility: Kitano Hospital /ID# 248785
state: Osaka
city: Osaka-shi
country: Japan
facility: Osaka City General Hospital /ID# 244210
state: Osaka
city: Osaka-shi
country: Japan
facility: National Hospital Organization Osaka National Hospital /ID# 238764
state: Osaka
city: Osaka-shi
country: Japan
facility: Otemae Hospital /ID# 250857
state: Osaka
city: Osaka-shi
country: Japan
facility: Osaka International Cancer Institute /ID# 248783
state: Osaka
city: Osaka-shi
country: Japan
facility: Japanese Red Cross Osaka Hospi /ID# 248784
state: Osaka
city: Osaka-shi
country: Japan
facility: Daini Osaka Police Hospital /ID# 240560
state: Osaka
city: Osaka-shi
country: Japan
facility: Osaka Metropolitan University Hospital /ID# 253203
state: Osaka
city: Osaka-shi
country: Japan
facility: Nippon Life Saiseikai Public Interest Foundation Nippon Life Hospital /ID# 243783
state: Osaka
city: Osakasayama-shi
country: Japan
facility: Kindai University Hospital /ID# 250851
state: Osaka
city: Takatsuki-shi
country: Japan
facility: Osaka Medical and Pharmaceutical University Hospital /ID# 249440
state: Osaka
city: Yao City
country: Japan
facility: Yao Tokushukai General Hospital /ID# 247884
state: Osaka
city: 東大阪市
country: Japan
facility: Ishikiriseiki Hospital /ID# 246077
state: Osaka
city: 泉大津市
country: Japan
facility: Hara Hospital /ID# 244846
state: Osaka
city: Saga-shi
country: Japan
facility: Saga Medical Center Koseikan /ID# 245816
state: Saga
city: Ageo-shi
country: Japan
facility: Ageo Central General Hospital /ID# 254515
state: Saitama
city: Asaka-shi
country: Japan
facility: TMG Asaka Medical Center /ID# 238761
state: Saitama
city: Fujimino City
country: Japan
facility: Kamifukuoka General Hospital /ID# 247890
state: Saitama
city: Kuki-shi
country: Japan
facility: Shinkuki General Hospital /ID# 254516
state: Saitama
city: Saitama-shi
country: Japan
facility: Saitama Citizens Medical Center /ID# 252573
state: Saitama
city: Wako-shi
country: Japan
facility: NHO Saitama National Hospital /ID# 245061
state: Saitama
city: Kusatsu-shi
country: Japan
facility: Omi Medical Center /ID# 258233
state: Shiga
city: Ritto
country: Japan
facility: Saiseikai Shiga Hospital /ID# 239381
state: Shiga
city: Hamada City
country: Japan
facility: National Hospital Organization Hamada Medical Center /ID# 250858
state: Shimane
city: Izumo-shi
country: Japan
facility: Shimane University Hospital /ID# 255194
state: Shimane
city: Izumo-shi
country: Japan
facility: Shimane Prefectural Central Ho /ID# 247895
state: Shimane
city: Masuda-shi
country: Japan
facility: Masuda Red Cross Hospital /ID# 248780
state: Shimane
city: Shizuoka-shi
country: Japan
facility: Shizuoka Saiseikai Genaral Hospital /ID# 239722
state: Shizuoka
city: Shimotsuga-gun
country: Japan
facility: Duplicate_Dokkyo Medical University Hospital /ID# 246764
state: Tochigi
city: Shimotsuke City
country: Japan
facility: Ishibashi General Hospital /ID# 243762
state: Tochigi
city: Utsunomiya-shi
country: Japan
facility: Tochigi Cancer Center /ID# 249445
state: Tochigi
city: Anan-shi
country: Japan
facility: Anan Medical Center /ID# 243781
state: Tokushima
city: Naruto-shi
country: Japan
facility: Tokushima Prefecture Naruto Hospital /ID# 239095
state: Tokushima
city: Tokushima-shi
country: Japan
facility: Tokushima University Hospital /ID# 252572
state: Tokushima
city: Bei Qu
country: Japan
facility: Meirikai Chuo General Hospital /ID# 238751
state: Tokyo
city: Bunkyo-ku
country: Japan
facility: Juntendo University Hospital /ID# 239096
state: Tokyo
city: Bunkyo-ku
country: Japan
facility: Tokyo Medical And Dental University Hospital /ID# 242178
state: Tokyo
city: Chuo-ku
country: Japan
facility: St.Luke's International Hospital /ID# 248787
state: Tokyo
city: Edogawa Ward
country: Japan
facility: Medical Plaza Edogawa /ID# 244220
state: Tokyo
city: Edogawa-ku
country: Japan
facility: Edogawa Hospital /ID# 239352
state: Tokyo
city: Fuchu City
country: Japan
facility: Tokyo Metropolitan Children's Medical Center /ID# 252189
state: Tokyo
city: Fuchu
country: Japan
facility: Tama Medical Center /ID# 247954
state: Tokyo
city: Fussa
country: Japan
facility: Fussa Hospital /ID# 240570
state: Tokyo
city: Higashimurayama-shi
country: Japan
facility: Tama-Hokubu Medical Center /ID# 245879
state: Tokyo
city: Itabashi-ku
country: Japan
facility: Tokyo Metropolitan Geriatric /ID# 249448
state: Tokyo
city: Itabashi-ku
country: Japan
facility: Duplicate_Teikyo University Hospital /ID# 247896
state: Tokyo
city: Kodaira
country: Japan
facility: Showa General Hospital /ID# 258235
state: Tokyo
city: Koto-ku
country: Japan
facility: Duplicate_The Cancer Institute Hospital Of JFCR /ID# 244216
state: Tokyo
city: Meguro-ku
country: Japan
facility: Mishuku Hospital /ID# 239378
state: Tokyo
city: Meguro-ku
country: Japan
facility: Kosei Chuo General Hospital /ID# 251011
state: Tokyo
city: Minato-ku
country: Japan
facility: Toranomon Hospital /ID# 251010
state: Tokyo
city: Musashino-shi
country: Japan
facility: Japanese Red Cross Musashino Hospital /ID# 246765
state: Tokyo
city: Nerima-ku
country: Japan
facility: Juntendo Univ Nerima Hospital /ID# 250292
state: Tokyo
city: Ome
country: Japan
facility: P_Ome Municipal General Hospital /ID# 248778
state: Tokyo
city: Setagaya Ward
country: Japan
facility: Metropolitan Research and Treatment Center for Blood Disorders /ID# 231384
state: Tokyo
city: Setagaya-ku
country: Japan
facility: National Center for Child Health and Development /ID# 243778
state: Tokyo
city: Shibuya-ku
country: Japan
facility: Japanese Red Cross Medical Center /ID# 239385
state: Tokyo
city: Shinagawa-ku
country: Japan
facility: NTT Medical Center Tokyo /ID# 240566
state: Tokyo
city: Shinjuku-ku
country: Japan
facility: Tokyo Medical University Hospital /ID# 252571
state: Tokyo
city: Shinjuku-ku
country: Japan
facility: Center hospital of the National Center for Global Health and Medicine /ID# 256189
state: Tokyo
city: Suginami-ku
country: Japan
facility: Kawakita General Hospital /ID# 257009
state: Tokyo
city: Sumida-ku
country: Japan
facility: Tokyo Metropolitan Bokutoh Hospital /ID# 241912
state: Tokyo
city: Sumida-ku
country: Japan
facility: The Fraternity Memorial Hospital /ID# 251685
state: Tokyo
city: Taito
country: Japan
facility: Eiju General Hospital /ID# 243763
state: Tokyo
city: 板橋区
country: Japan
facility: Toshima Hospital /ID# 240878
state: Tokyo
city: Tottori-shi
country: Japan
facility: Tottori Prefectural Central Ho /ID# 245877
state: Tottori
city: Yonago-shi
country: Japan
facility: Yonago Medical Center /ID# 240572
state: Tottori
city: Yonago-shi
country: Japan
facility: Tottori University Hospital /ID# 244215
state: Tottori
city: Kurobe-shi
country: Japan
facility: Kurobe City Hospital /ID# 254493
state: Toyama
city: Kinokawa City
country: Japan
facility: Naga municipal Hospital /ID# 250259
state: Wakayama
city: Tanabe-shi
country: Japan
facility: Social Insurance Kinan Hosp /ID# 251684
state: Wakayama
city: Wakayama-shi
country: Japan
facility: Wakayama Rosai Hospital /ID# 250293
state: Wakayama
city: 海南市
country: Japan
facility: Kainan Medical Center /ID# 240825
state: Wakayama
city: Higashiokitama-gun
country: Japan
facility: Okitama Public General Hospital /ID# 242710
state: Yamagata
city: Yamagata-shi
country: Japan
facility: Yamagata University Hospital /ID# 246763
state: Yamagata
city: Iwakuni-shi
country: Japan
facility: NHO Iwakuni Clinical Center /ID# 242170
state: Yamaguchi
city: Shunan-shi
country: Japan
facility: Tokuyama Central Hospital /ID# 242380
state: Yamaguchi
city: Ube-shi
country: Japan
facility: Yamaguchi University Hospital /ID# 245060
state: Yamaguchi
city: Yamaguchi City
country: Japan
facility: Ogori Daiichi General Hospital /ID# 246761
state: Yamaguchi
city: Chuo-shi
country: Japan
facility: University of Yamanashi Hospital /ID# 246006
state: Yamanashi
city: Chiba
country: Japan
facility: Inoue Memorial Hospital /ID# 239351
city: Chiba
country: Japan
facility: National Hospital Organization Chiba Medical Center /ID# 266755
city: Fujisawa-shi
country: Japan
facility: Fujisawa City Hospital /ID# 239375
city: Fukuoka-shi
country: Japan
facility: Harasanshin Hospital /ID# 240881
city: Hachinohe-shi
country: Japan
facility: Hachinohe Red Cross Hospital /ID# 250850
city: Hachioji
country: Japan
facility: Tokai University Hachioji Hospital /ID# 266804
city: Higashihiroshima-shi
country: Japan
facility: Higashihiroshima Medical Center /ID# 250849
city: Hiroshima
country: Japan
facility: Hiroshima Prefecture Hospital /ID# 252215
city: Ikeda
country: Japan
facility: Ikeda City Hospital /ID# 266802
city: Kawaguchi-shi
country: Japan
facility: Kawaguchi Municipal Medical Center /ID# 246080
city: Kitakyushu-shi
country: Japan
facility: Kitakyusyu General Hospital /ID# 244212
city: Mitaka
country: Japan
facility: Kyorin University - Mitaka Campus /ID# 243777
city: Saiki-shi
country: Japan
facility: Nankai Medical Center /ID# 241914
city: Saitama
country: Japan
facility: Saitama City Hospital /ID# 240567
city: Sakata-shi
country: Japan
facility: Nihonkai General Hospital /ID# 242024
city: Tachikawa
country: Japan
facility: Tachikawa Hospital /ID# 245878
city: Takatsuki
country: Japan
facility: Takatsuki Red Cross Hospital /ID# 266756
city: Tokyo
country: Japan
facility: Toshiba General Hospital /ID# 250294
city: Toyama
country: Japan
facility: Toyama Hospital /ID# 243779
city: Yamagata
country: Japan
facility: Shonai Hospital /ID# 254514
Study officials:
affiliation: AbbVie
name: ABBVIE INC.
role: STUDY_DIRECTOR
References: