Clinical trial NCT05955300: Nutrition and Movement to Improve Quality of Life With Knee Osteoarthritis
Official title: Evidence Based Training Program Combined With Nutrition Therapy for Patients With Knee Osteoarthritis
Study type: INTERVENTIONAL
Overall status: RECRUITING
Phase: NA
Conditions: Osteo Arthritis Knee
Keywords: Knee
Osteoarthritis
Exercise therapy
Nutrition
Quality of life
Lead sponsor: St. Pölten University of Applied Sciences
Sponsor class: OTHER
Collaborators: name: University of Vienna
name: Danube University Krems
First posted: 2023-07-21
Enrollment: 60
Sex: ALL
Minimum age (years): 50
Maximum age (years): 75
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Intervention model description: Clinical trial with 2 groups
Primary purpose: TREATMENT

Brief summary: This project aims to evaluate the effects of an evidence-based training program in combination with an antiinflammatory dietetic intervention on quality of life for patients with knee osteoarthritis

Detailed description: Osteoarthritis (OA) is the most prevalent arthritic disease worldwide characterized by pain, effusion and stiffness leading to functional decline and reduced quality of life (QL). It has been long considered as a degenerative disease of cartilage resulting from bodily wear and tear that affect the entire joint structure. However, there is accumulating evidence that inflammation plays a key role in the OA pathogenesis. Triggered from tissue damage and by metabolic dysfunction, inflammatory processes within the joint may trigger the development of chronic low-grade inflammation.

Factors that contribute to chronic low-grade inflammation include a nutrient overload, a metabolic surplus, pro-inflammatory cytokines and adipokines. Knee OA is the most common form of OA with prevalence rising with age peaked at around 50 years of age affecting more than 250 million people worldwide. Exercise therapy (ET) is an effective component of early treatment and is therefore recommended as a first line treatment. Good Life with osteoArthritis in Denmark (GLA:D®) represents an evidence-based treatment plan for knee OA and optimizes the implementation of ET. However, ET mainly addresses physical and functional deficits in patients with knee OA, but not the inflammatory processes. Due to the association of chronic low-grad inflammation with dietary patterns, nutrition plays a significant role in inflammation-related diseases. A plant-based, anti-oxidative and anti-inflammatory therapeutic diet helps to improve symptoms leading to improved quality of life. When implementing a therapeutic diet, it should be attractive for patients and regional needs should be considered. This might increase adherence to therapeutic diet and will have an environmental impact - the New Nordic Diet (NND) seems to fulfil these requirements. To our knowledge no study has examined the influence of NND on symptoms and QL in OA. Further, there is a lack of knowledge concerning the impact of exercise therapy AND nutrition therapy on symptoms and QL in patients with knee OA.

Aims

1. To evaluate the effect of a nutrition therapy combined with exercise therapy on QL in patients knee OA
2. To investigate the impact of a nutrition therapy combined with exercise therapy on symptoms, nutrition and inflammation status and joint function in patients with knee OA

Eligibility criteria: Inclusion Criteria:

* Mild to moderate knee osteoarthritis

Exclusion Criteria:

* Musculosceletal disorders which obviates a participation in the training program
* kognitive deficits
* internal, neurological and mental diseases
* drug and/or alcohol abuse

Primary outcomes:
measure: Knee Injury and Osteoarthritis Outcome Score (Quality of Life)
timeFrame: 9 Month
Secondary outcomes:
Other outcomes:
Locations:
city: St. Pölten
country: Austria
facility: Sankt Pölten University of Applied Sciences
state: Lower Austria
city: St. Poelten
country: Austria
facility: St. Poelten University of Applied Sciences
Study officials:
References: