louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT02718196: Testing and Development of a Sleep Training Mobile Health Application
Official title: Testing and Development of a Sleep Training Mobile Health Application to Address Sleep Problems in the First Two Years of Life
Study type: INTERVENTIONAL
Overall status: WITHDRAWN
Phase: NA
Conditions: Sleep
Lead sponsor: Yale University
Sponsor class: OTHER
First posted: 2016-03-24
Enrollment: 0
Sex: ALL
Minimum age (years): 6
Maximum age (years): 24
Standard ages: CHILD
Accepts healthy volunteers: yes
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: SUPPORTIVE_CARE

Brief summary: The specific aims of this study are : 1) To pilot test the alpha build prototype of the sleep training smartphone application using a sample of parents looking for sleep training advice online. 1a) To assess the efficacy of the application in helping parents with the sleep training process 1b) To assess the 'workability' of the application 2) Use feedback to guide the next round of development with the goal of building out the applications functionality and increasing usability.

Detailed description: Problems with bedtime and night-wakings are common in early childhood. Behavioral interventions to address these sleep problems are commonly referred to as "sleep training" and are effective but difficult for some parents to perform. The investigators have developed a prototype of a novel smartphone application designed to assist parents throughout this process.

The smartphone application first collects basic information from the parents, including: first name of child, number of caregivers participating in bedtime, tolerance of caregivers for crying, and basic information about timing of sleep and wake, as well as information about the usual order of events at bedtime. At each step, a brief (2-3 paragraph) is provided to explain the rationale for the next step, as well as concrete advice on how to succeed. It then walks parents through proven techniques to improve sleep in children in a stepwise fashion.

Eligibility criteria: Inclusion Criteria:

* english speaking
* parent of child age 6-24 months
* target child sleeping in crib in his or her own room (not the same room as the parents or a sibling)
* actively looking to sleep train their child
* own an iOS or Android smartphone

Exclusion Criteria:

* bedsharing/cosleeping with child
* target child has a known developmental delay
* target child has a significant health issue affecting his/her sleep (failure to thrive, congenital heart disease, etc).

Primary outcomes:
measure: Change in average number of night wakings by Brief Infant Sleep Questionnaire (BISQ)
timeFrame: study entry and 1 month
measure: Change in average number of night wakings by Brief Infant Sleep Questionnaire (BISQ)
timeFrame: study entry and 3 months
measure: Perception of child's sleep problem- Brief Infant Sleep Questionnaire (BISQ)
timeFrame: study entry
measure: Perception of child's sleep problem- Brief Infant Sleep Questionnaire (BISQ)
timeFrame: 3 months
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
References:
Clinical trial NCT04960696: Effect on Ocular Surface Symptoms of Online Education
Official title: An Evaluation of the Effect on Ocular Surface Symptoms of Online Education During the Pandemic
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Eye Diseases
Ocular Surface Disease
Dry Eye
Keywords: Pandemic
online education
ocular health
tear break up time
schirmer
Lead sponsor: Kahramanmaras Sutcu Imam University
Sponsor class: OTHER
First posted: 2021-07-14
Enrollment: 315
Sex: ALL
Minimum age (years): 6
Maximum age (years): 30
Standard ages: CHILD
ADULT
Observational model: ECOLOGIC_OR_COMMUNITY
Time perspective: OTHER
Sampling method: PROBABILITY_SAMPLE
Study population: Students aged 6-30 who receive online education during the pandemic period

Brief summary: retrospective, observational study.

Detailed description: Aim: The aim of this study was to investigate the effects on ocular surface symptoms of students taking online education, which was a part of the distance learning model during the COVID-19 pandemic, to be able to prevent the formation of irreversible damage with early diagnosis and treatment. With recommendations that can be simply applied, it was aimed to protect ocular health.

Material and Method: The study included 315 students who were undertaking online education and presented at the Ophthalmology Department of a tertiary level university hospital. A record was made of sociodemographic data, Schirmer test results, tear break-up time (TBUT) measurements, and Ocular Surface Disease Index (OSDI) scores. The data were analyzed statistically using SPSS vn. 22.0 software, and a value of p\<0.05 was accepted as statistically significant.

Eligibility criteria: Inclusion Criteria:

Online education \>6 years \<30 years student

Exclusion Criteria:

not student not taking online education \<6 years \>30 years

Primary outcomes:
measure: Dry eye symptom scale: ocular symptom scale index (OSDI)
timeFrame: baseline
measure: Dry eye symptom scale:Tear break up time (TBUT)
timeFrame: baseline
measure: Dry eye scale:Schirmer
timeFrame: baseline
Secondary outcomes:
Other outcomes:
Locations:
city: Kahramanmaraş
country: Turkey
facility: Abdullah Beyoğlu
state: In The USA Or Canada, Please Select...
Study officials:
affiliation: Kahramanmaraş Sütçü İmam Üniversitesi Tıp Fakültesi
name: Abdullah Beyoğlu
role: STUDY_CHAIR
References:
Clinical trial NCT00004296: Multicenter Study of Nontuberculous Mycobacteria in Cystic Fibrosis Patients
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Cystic Fibrosis
Atypical Mycobacterium Infection
Keywords: atypical mycobacterium infection
bacterial infection
cardiovascular and respiratory diseases
cystic fibrosis
genetic diseases and dysmorphic syndromes
immunologic disorders and infectious disorders
mycobacterium infection
rare disease
Lead sponsor: Office of Rare Diseases (ORD)
Sponsor class: NIH
Collaborators: name: University of North Carolina
First posted: 1999-10-19
Enrollment: 1000
Sex: ALL
Minimum age (years): 10
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Time perspective: OTHER

Brief summary: OBJECTIVES: I. Determine the prevalence of nontuberculous mycobacteria in sputum cultures from patients with cystic fibrosis.

II. Compare the clinical course of patients with negative versus positive cultures.

Detailed description: PROTOCOL OUTLINE: Participants are screened for nontuberculous mycobacteria (NTM) with 3 sputum acid-fast bacilli smears and mycobacterial cultures, with speciation of positive cultures, collected over 1 year. Demographic data, diagnostic criteria, clinical measurements, and other respiratory pathogen data are collected using the Cystic Fibrosis Foundation Patient Registry Questionnaire.

NTM-positive patients (cases) matched with NTM-negative controls identified in screening are followed every 3 months for 15 months. Cases are evaluated for NTM burden during the first 3 months.

Appropriate therapy is offered to consistently NTM-positive cases. Lung transplant recipients are removed from study.

Eligibility criteria: PROTOCOL ENTRY CRITERIA:

Patients over age 10 with cystic fibrosis documented as follows:

* Pilocarpine sweat chloride test at least 60 mEq/L OR
* Genotyping or transepithelial potential difference AND
* Clinical symptoms of suppurative respiratory disease or pancreatic insufficiency

Able to produce at least 3 sputum samples

* Bronchoscopy specimens acceptable
* Throat/nasal specimens not acceptable

No Pseudomonas cepacia colonization

Primary outcomes:
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
affiliation: University of North Carolina
name: Ken Olivier
role: STUDY_CHAIR
References:
citation: Whittier S, Olivier K, Gilligan P, Knowles M, Della-Latta P. Proficiency testing of clinical microbiology laboratories using modified decontamination procedures for detection of nontuberculous mycobacteria in sputum samples from cystic fibrosis patients. The Nontuberculous Mycobacteria in Cystic Fibrosis Study Group. J Clin Microbiol. 1997 Oct;35(10):2706-8. doi: 10.1128/jcm.35.10.2706-2708.1997.
citation: Olivier KN.: Collaborative CFF/NCRR study of the epidemiology of nontuberculous mycobacteria in cystic fibrosis. Pediatric Pulmonology Suppl. 19: 145-146, 1999.
Clinical trial NCT00050596: Comparison Study of MDX-010 (CTLA-4) Alone and Combined With Docetaxel in the Treatment of Patients With Hormone Refractory Prostate Cancer
Official title: A Randomized Study Comparing 4 Monthly Doses of MDX-010 (CTLA-4) as a Single Agent or Used in Combination With a Single Dose of Docetaxel in Patients With Hormone-Refractory Prostate Cancer
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE2
Conditions: Prostate Cancer
Lead sponsor: Bristol-Myers Squibb
Sponsor class: INDUSTRY
First posted: 2002-12-17
Sex: MALE
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: CROSSOVER
Primary purpose: TREATMENT

Brief summary: The primary objectives of the study are to determine the safety and activity of multiple doses of MDX-010 in patients with hormone-refractory prostate cancer (HRPC), and to determine the safety and activity profile of a single dose of cytotoxic chemotherapy (docetaxel) in combination with MDX-010


Eligibility criteria: Inclusion Criteria:

* Clinical diagnosis of adenocarcinoma of the prostate.
* Metastatic prostate cancer (positive bone scan or measurable disease).
* Progressive disease after androgen deprivation.
* No prior chemotherapy or immunotherapy (tumor vaccine, cytokine, or growth factor given to control prostate cancer).

Exclusion Criteria:

* Other prior malignancy, except for adequately treated basal or squamous cell skin cancer or superficial bladder cancer, or any other cancer from which the patient has been disease-free for greater than or equal to 5 years.
* Previous occurrence of autoimmune disease.
* Active infection requiring therapy including HIV or chronic hepatitis.

Primary outcomes:
Secondary outcomes:
Other outcomes:
Locations:
city: Tucson
country: United States
facility: Advanced Clinical Therapeutics
state: Arizona
city: Long Beach
country: United States
facility: Pacific Shores Medical Group
state: California
city: San Diego
country: United States
facility: San Diego Uro-Research
state: California
city: New Orleans
country: United States
facility: LSU Health Science Center/ Stanley S. Scott Cancer Center (uptown campus)
state: Louisiana
city: Hershey
country: United States
facility: Milton S. Hershey Medical Center
state: Pennsylvania
city: Providence
country: United States
facility: University Urological Research Institute
state: Rhode Island
city: Myrtle Beach
country: United States
facility: Grand Strand Urology
state: South Carolina
city: Arlington
country: United States
facility: Urology Associates of North Texas
state: Texas
city: Salt Lake City
country: United States
facility: Utah Cancer Specialists
state: Utah
city: Salt Lake City
country: United States
facility: Salt Lake Research
state: Utah
city: Seattle
country: United States
facility: Seattle Cancer Center Alliance
state: Washington
Study officials:
affiliation: Bristol-Myers Squibb
name: Bristol-Myers Squibb
role: STUDY_DIRECTOR
References:
Clinical trial NCT02852096: Assessing Her2/Neu Expression in Gastric Cancer With Dual or Multiple Tumor Tissue Paraffin Blocks
Official title: Assessing Her2/Neu Expression in Gastric Cancer With Dual or Multiple Tumor Tissue Paraffin Blocks
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Gastric Cancer
HER-2
Keywords: gastric cancer
Her2/neu
dual paraffin blocks
trastuzumab
Lead sponsor: Shanghai Zhongshan Hospital
Sponsor class: OTHER
First posted: 2016-08-02
Enrollment: 600
Sex: ALL
Minimum age (years): 18
Maximum age (years): 80
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: DIAGNOSTIC

Brief summary: One paraffin block is routinely used for Human Epidermal Growth Factor Receptor 2 (Her2/neu) immunohistochemistry (IHC) assessment. Here, investigators investigated if picking two or multiple paraffin blocks for Her2/neu evaluation is an economical, efficient and practical method, which may reduce false-negativity of Her2/neu IHC assessment due to intratumoral heterogeneity.


Eligibility criteria: Inclusion Criteria:

Age between 18 to 80; Received curative surgery with primary gastric adenocarcinoma; Did not receive any preoperative treatment.

Exclusion Criteria:

None.

Primary outcomes:
measure: The positive rate of cohort using dual or multiple tumor tissue paraffin blocks
timeFrame: 24 months
Secondary outcomes:
Other outcomes:
Locations:
city: Shanghai
country: China
facility: 180 Fenglin Road
state: Shanghai
Study officials:
affiliation: Fudan University
name: Yingyong Hou, M.D. & Ph.D.
role: STUDY_CHAIR
References:
citation: Bang YJ, Van Cutsem E, Feyereislova A, Chung HC, Shen L, Sawaki A, Lordick F, Ohtsu A, Omuro Y, Satoh T, Aprile G, Kulikov E, Hill J, Lehle M, Ruschoff J, Kang YK; ToGA Trial Investigators. Trastuzumab in combination with chemotherapy versus chemotherapy alone for treatment of HER2-positive advanced gastric or gastro-oesophageal junction cancer (ToGA): a phase 3, open-label, randomised controlled trial. Lancet. 2010 Aug 28;376(9742):687-97. doi: 10.1016/S0140-6736(10)61121-X. Epub 2010 Aug 19.
Clinical trial NCT07010796: Treatment of Adipose Tissue and Skin Laxity at the Buttocks by PDLLA, US and RF
Official title: Treatment of Adipose Tissue and Skin Laxity at the Buttocks by PDLLA, US and RF
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Local Fat Deposits
Lead sponsor: Elite Laser Clinic
Sponsor class: OTHER
First posted: 2025-06-08
Enrollment: 10
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Participants were selected due to their desire to reduce fat deposits at the buttock area as well as tightening lax skin.

Brief summary: Local body fat and lax skin is treated with a combined approach of PDLLA injections and topical ultrasound and radiofrequency.


Eligibility criteria: Inclusion Criteria:

* adults over 18 years
* patients eligible to be treated with radiofrequency and ultrasound
* all genders

Exclusion Criteria:

* patients displaying contraindications for treatment with radiofrequency and ultrasound
* pregnancy
* immune diseases
* active virus infections

Primary outcomes:
measure: change of fat deposits
timeFrame: From enrollment to the end of treatment at 2 months
Secondary outcomes:
Other outcomes:
Locations:
city: Madrid
country: Spain
facility: Elite Laser Clinic Organization
Study officials:
References:
Clinical trial NCT05470335: Nurse-led Sheath Insertion in Cardiac Patients
Official title: Patient Comfort, Success Rate, Procedure Time and Complications During Sheath Insertion by Nurses and Physicians in Connection With Invasive Examination and Treatment of Cardiac Patients
Study type: INTERVENTIONAL
Overall status: RECRUITING
Phase: NA
Conditions: Coronary Artery Disease
Lead sponsor: Zealand University Hospital
Sponsor class: OTHER
First posted: 2022-07-22
Enrollment: 1000
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The aim of project NUSHI is to elucidate, that radial sheath insertion can be performed by nurses and physicians with the same level of comfort and safety.

Detailed description: Background: Insertion of sheath in the radial artery in connection with examination and treatment of patients with coronary artery disease is usually performed by specialized invasive cardiologists or trainees. Whether sheath insertion can be performed by nurses with the same level of comfort and pain is uncertain.

Eligibility: Patients referred for coronary angiography (CAG) and/or percutaneous coronary intervention (PCI) due to suspicion of coronary artery disease are included

Randomization: Patients are randomized 1:1 to sheath insertion by nurse or physician

Methods: Insertion of 5 or 6 radial sheaths is performed in local anesthesia

Outcome measures: Comfort and pain level is registered from immediately after sheath insertion until start of CAG/PCI.

Additional outcome measures: Oximetry test is performed immediately after sheath removal - and repeated after 1 month in case of occlusion. Any complication is recorded from the patient enters the wake-up room until discharge.

All patients are contacted after 1 year in order to register adverse events.

Eligibility criteria: Inclusion Criteria:

* patients suspected of having coronary artery disease
* with normal puls oxymetry on the right hand
* understands patient information and accepts to participate

Exclusion Criteria:

* under consideration for cardiac valve replacement
* systolic blood pressure persistently \>180 mmHg

Primary outcomes:
measure: pain level
timeFrame: through study completion, an average of 1 year
measure: comfort level
timeFrame: through study completion, an average of 1 year
Secondary outcomes:
measure: success rate
timeFrame: through study completion, an average of 1 year
measure: time consumption
timeFrame: through study completion, an average of 1 year
measure: convertion
timeFrame: through study completion, an average of 1 year
measure: complications
timeFrame: through study completion, an average of 1 year
Other outcomes:
Locations:
city: Roskilde
country: Denmark
facility: Zealand University Hospital
state: Danmark
Study officials:
affiliation: Chief Physician
name: Henning Kelbæk, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT01280435: Islide-Establishing a Clinical Dermatopathology Online Discourse System
Official title: Islide-Establishing a Clinical Dermatopathology Online Discourse System
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Biopsy
Keywords: Online Discourse
e-Learning
Biopsy
Virtual Pathologic Section
Lead sponsor: Taipei Medical University WanFang Hospital
Sponsor class: OTHER
First posted: 2011-01-20
Enrollment: 80
Sex: ALL
Minimum age (years): 20
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: interns

Brief summary: The trend is changed by a large number of low-cost computers, large-capacity computing power, and the rapid advent of network bandwidth. From the Internet to the WWW to Web2.0, the technology in addition brings impact on economic, social, and technological, but also on medical education about knowledge delivery globally and learning patterns.

Currently, many scholars start to take the affection of social network seriously. In the medical field, ECGpedia is the typical successful example. There are more than 250,000 members from 188 different countries in the website. On the other hand, the effect of data computing and transition improve the development of Gigapixel image presentation. For example, users can zoom in and zoom out on GoogleMap. The research team has being worked on this kind of search engine on pathology and anatomy slides in past three years. For education purpose, students can observe slides by using a virtual microscope directly.

This research will target on establishing a Clinical Dermatopathology Online Discourse System (iSlide). It will combine a virtual microscope platform and a biopsy diagnosis eLearning System. This survey will be focused on evaluating of this platform. The object is all interns in dermatopathology department at Wan Fang Hospital this semester. All the new physicians can learn from experienced experts. Users who have questions can search for help from others via this website. They can get assistance by thinking procedure learning model -scheme inductive and pattern recognition. In doing so, clinicians and pathologists can discuss with each other through this system. It also can improve the education and research development in this field.


Eligibility criteria: Inclusion Criteria:

* All interns in dermatology department of Wan Fang Hospital this semester.

Exclusion Criteria:

* N/A

Primary outcomes:
Secondary outcomes:
Other outcomes:
Locations:
city: Taipei
country: Taiwan
facility: Taipei Medical University
Study officials:
affiliation: Taipei Medical University
name: Yu-Chuan Li
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT04152135: Hemodynamic Changes With Passive Leg Raising Maneuver in Patients Undergoing Arthroscopic Shoulder Surgery
Official title: Evaluation of Volume Status by Passive Leg Removal Maneuver and Vena Cava Inferior Diameter Measurements Before the Position of Patients in Arthroscopic Shoulder Surgery
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Arthroscopic Shoulder Surgery
Keywords: passive leg raising maneuver, vena cava inferior diameter
Lead sponsor: Diskapi Teaching and Research Hospital
Sponsor class: OTHER
First posted: 2019-11-05
Enrollment: 50
Sex: ALL
Minimum age (years): 18
Maximum age (years): 65
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: CASE_CONTROL
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: ASA 1-2 status patients between the ages of 18-65 to be performed arthroscopic shoulder surgery with informed consent

Brief summary: After intubation of the patients who are undergoing arthroscopic shoulder surgery, plethysmographic waveform will be recorded with blood pressure, heart rate and end-tidal carbon dioxide values and inferior vena cava (IVC) diameter will be measured by ultrasound. New hemodynamic values will be measured after passive leg raising maneuver. Blood pressure, heart rate, end-tidal carbon dioxide values will be re-measured and plethysmographic waveform will be recorded after beach chair position for surgery.

Detailed description: Patients aged between 18-65 years who are undergoing arthroscopic shoulder surgery will be examined. After giving detailed information, voluntary certificate will be taken from patients who accept to participate in the study. Heart rate, oxygen saturation and blood pressure values will be recorded by routine monitoring. After intubation of the patients, plethysmographic waveform will be recorded with blood pressure, heart rate and end-tidal carbon dioxide values and IVC diameter will be measured by ultrasound. New hemodynamic values will be measured after passive leg raising maneuver. Blood pressure, heart rate, end-tidal carbon dioxide values will be re-measured and plethysmographic waveform will be recorded after beach chair position for surgery.

Eligibility criteria: Inclusion Criteria:

* 18-65 years old patients,
* The American Society of Anesthesiologists (ASA) physical status classification score 1-2,
* Patients scheduled for arthroscopic shoulder surgery, intubated, sitting position

Exclusion Criteria:

* Patient refusal,
* Patients with current heart and valve disease,
* Patients with ASA 3-4 status,
* Emergency cases

Primary outcomes:
measure: passive leg raising maneuver
timeFrame: 2 minutes
measure: vena cava inferior diameter
timeFrame: 2 minutes
Secondary outcomes:
measure: Blood pressure
timeFrame: 2 minutes
measure: Heart rate
timeFrame: 2 minutes
measure: End-tidal CO2
timeFrame: 2 minutes
measure: plethysmographic waveform
timeFrame: 2 minutes
Other outcomes:
Locations:
Study officials:
References: