Clinical trial NCT02938416: The Effect of Isokinetic Strengthening Training
Official title: Comparison of the Functional Recovery and Cytokines Changes Between Isokinetic and Isotonic Training in Patients With Acute Stroke, After Total Hip Replacement or After Total Knee Replacement
Study type: INTERVENTIONAL
Overall status: RECRUITING
Phase: NA
Conditions: Resistance Training
Stroke
Arthroplasty, Replacement, Hip
Arthroplasty, Replacement, Knee
Lead sponsor: Taichung Veterans General Hospital
Sponsor class: OTHER
First posted: 2016-10-19
Enrollment: 126
Sex: ALL
Minimum age (years): 40
Maximum age (years): 70
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: Our participants will include 40 patients within one month of stroke, 43 patients who received total hip replacement or total knee replacement two to four weeks before. The participants will be randomly assigned to isokinetic, isotonic or isometric training groups. Outcome measures including isometric peak torque of hip/knee at 90 degree of flexion, peak torque of hip/knee at angular velocity of 60 degree/s and 120 degree/s, Short Form 36 (SF-36), the Timed Up and Go test, the Oxford Hip/knee Score, the plasma concentration of hsCRP, and the level of substance P in saliva will be collected at the beginning and 4 weeks after the training program. Statistical significant differences will be determined between the improvement of outcome measures of the isokinetic and the isotonic training groups.

Detailed description: Our participants will include 40 patients within one month of stroke, 43 patients who received total hip replacement or total knee replacement two to four weeks before. The participants will be randomly assigned to isokinetic, isotonic or isometric training groups. Outcome measures including isometric peak torque of hip/knee at 90 degree of flexion, peak torque of hip/knee at angular velocity of 60 degree/s and 120 degree/s, Short Form 36 (SF-36), the Timed Up and Go test, the Oxford Hip/knee Score, the plasma concentration of hsCRP, and the level of substance P in saliva will be collected at the beginning and 4 weeks after the training program. Statistical significant differences will be determined between the

Eligibility criteria: Inclusion Criteria:

* within one month of acute stroke
* receive total hip/knee replacement within two to four weeks before

Exclusion Criteria:

* cannot perform from sitting to standing
* Body Mass Index \> 30
* Lower limbs fracture history
* Diabetic polyneuropathy
* Cardiopulmonary diseases that impede exercise prescription
* Impaired cognitive function
* Infectious disease during the study period that may cause cytokine changes

Primary outcomes:
measure: Peak torque
timeFrame: 4 weeks
Secondary outcomes:
measure: Timed Up and Go test
timeFrame: 4 weeks
measure: Short Form 36 (SF-36) questionnaire
timeFrame: 4 weeks
measure: Oxford Hip/Knee Score
timeFrame: 4 weeks
measure: The plasma concentration of hsCRP, and the level of substance P in saliva
timeFrame: 4 weeks
Other outcomes:
Locations:
city: Taichung City
country: Taiwan
facility: Department of Physical Medicine and Rehabilitation
Study officials:
affiliation: Department of Physical Medicine and Rehabilitation
name: Yuan-Yang Cheng, MD, PhD
role: PRINCIPAL_INVESTIGATOR
References:
citation: Cheng YY, Liu CC, Lin SY, Lee CH, Chang ST, Wang SP. Comparison of the Therapeutic Effects Between Isokinetic and Isotonic Strength Training in Patients After Total Knee Replacement: A Prospective, Randomized Controlled Trial. Orthop J Sports Med. 2022 Jun 21;10(6):23259671221105852. doi: 10.1177/23259671221105852. eCollection 2022 Jun.