Clinical trial NCT06676358: Evaluation of the Effects of Smoking on Trabecular Bone Microarchitecture Using CBCT in Periodontal Disease
Official title: Evaluation of the Effects of Smoking on Trabecular Bone Microarchitecture Using CBCT in Periodontal Disease
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Cone Beam Computed Tomography
Periodontitis
Diagnosis of Bone Quality
Diagnosis, Oral
Smoking, Cigarette
Keywords: cone beam computed tomography
Periodontitis
Diagnosis
Lead sponsor: Okan University
Sponsor class: OTHER
First posted: 2024-11-06
Enrollment: 90
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: OTHER
Time perspective: CROSS_SECTIONAL
Sampling method: NON_PROBABILITY_SAMPLE
Study population: A sample size of 15 patients per group (6 groups, total 90 patients) was calculated using the G\*Power 3.1.9.2 software (power \[1-β\] = 0.80, alpha level \[α\] = 0.05, effect size \[f\] = 0.4)

Brief summary: The purpose of this cross-sectional study is to evaluate the morphometric properties of trabecular bone quality using Cone-beam computed tomography in periodontal disease at different stages, comparing smokers and non-smokers.

Detailed description: This cross-sectional study aimed to analyze changes in trabecular bone quality associated with smoking inindividuals with periodontal disease using morphometric analysis of Cone Beam Computed Tomography (CBCT)images. Materials-Methods: The study involved 90 systemically healthy patients who were smokers (\>=10cigarettes/day) or non-smokers, and were indicated for CBCT.Clinical periodontal parameters (plaque index, gingival index, probing pocket depth, bleeding on probing, clinicalattachment loss (CAL)) were recorded. Participants were divided into two main groups based on smoking statusand three subgroups based on periodontal diagnosis: gingivitis, Stage I-II periodontitis, and Stage III-IVperiodontitis (n=15). Mandibular first molars and central incisors without prosthetic restorations, endodonticlesions, or root canal treatments were included. Two volumetric regions of interest (ROIs) with dimensions of5x5x10 mm were selected around the apices of these teeth: posterior ROI and anterior ROI. Trabecular bonemicro-architecture was analyzed using the BoneJ plugin for morphometric parameters: anisotropy (DA), bonevolume fraction (BV/TV), trabecular thickness (Tb.Th), and trabecular separation (Tb.Sp). Statistical analysis wasperformed using Student's t-test, one-way ANOVA, and Kruskal-Wallis tests.

Eligibility criteria: Inclusion Criteria:

* Individuals aged 18 years or older who are systemically healthy.
* Presence of mandibular molars and mandibular anterior teeth.
* No pathologies affecting the alveolar bone.
* No history of orthodontic treatment.
* No use of medication that may impact bone health.
* No history of radiation or chemotherapy treatment.
* Selected mandibular molars and central incisors must be free of caries. Selected teeth must not have crowns, root canal treatments, or endodontic lesions.

Exclusion Criteria:

* Patients who are exhibiting signs of occlusal trauma
* Patients who are bruxism

Primary outcomes:
measure: Bone morphometric parameters
timeFrame: Baseline
measure: Bone morphometric parameters
timeFrame: Baseline
measure: Bone morphometric parameters
timeFrame: Baseline
measure: Bone morphometric parameters
timeFrame: Baseline
Secondary outcomes:
measure: Clinical periodontal parameters
timeFrame: Baseline
measure: Clinical periodontal parameters
timeFrame: Baseline
measure: Clinical periodontal parameters
timeFrame: Baseline
measure: Clinical periodontal parameters
timeFrame: Baseline
measure: Clinical periodontal parameters
timeFrame: Baseline
Other outcomes:
Locations:
city: Istanbul
country: Turkey
facility: Okan Univercity
Study officials:
References: