louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT06339073: CT-based Model for Predicting Prolonged Weaning in Patients With Abdominal Trauma
Official title: CT-based Model for Predicting Prolonged Weaning From Mechanical Ventilation in Patients With Abdominal Trauma: a Retrospective Cohort Study
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Wounds and Injuries
Ventilation Therapy; Complications
Keywords: computed tomography
prolonged weaning
ventilation
trauma
Lead sponsor: Jinling Hospital, China
Sponsor class: OTHER
First posted: 2024-04-01
Enrollment: 1023
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Observational model: COHORT
Time perspective: RETROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Patients with abdominal trauma admitted to the General Surgical Department of Jinling Hospital from January 2010 to April 2023 were screened for eligibility.

Brief summary: Critically ill patients often require tracheal intubation for mechanical ventilation, and timely weaning is crucial for airway management and reducing complications. However, there is currently a lack of an effective tool to predict weaning time in critically ill patients. This retrospective study established an effective nomogram model for predicting the time of weaning from mechanical ventilation in abdominal trauma patients by considering multiple perspectives. The model has been validated and demonstrated good performance in terms of discrimination, calibration, and clinical utility. Moreover, the model can effectively predict the prognosis of critically ill patients. The findings of this study have important implications for guiding respiratory management in clinically critically ill patients, particularly trauma patients.


Eligibility criteria: Inclusion Criteria:

* (1) with information on survival status and time;
* (2) aged 18-80 years;
* (3) admitted to ICU;
* (4) with abdominal CT performed within 1-week post-trauma;
* (5) use of mechanical ventilation.

Exclusion Criteria:

* (1) low-quality CT images;
* (2) history of mental illness.

Primary outcomes:
measure: Prolonged mechanical ventilation
timeFrame: through whole hospitalization of each participant, an average of 25 days
Secondary outcomes:
Other outcomes:
Locations:
city: Nanjing
country: China
facility: the General Surgical Department of Jinling Hospital
state: Jiangsu
Study officials:
References:
Clinical trial NCT03557073: The Effects of Postoperative Physician Phone Calls for Hand and Wrist Fractures
Official title: The Effects of Postoperative Physician Phone Calls for Hand and Wrist Fractures: a Single-blinded, Prospective, Randomized Controlled Trial
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Hand Injuries
Trauma
Hand Injuries and Disorders
Keywords: Hand injuries
Hand trauma
Patient reported outcomes
Lead sponsor: Indiana University
Sponsor class: OTHER
First posted: 2018-06-14
Enrollment: 24
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Intervention model description: Participants are randomized to receiving a postoperative phone call or not receiving a postoperative phone call by a physician.
Primary purpose: TREATMENT

Brief summary: This study seeks to determine if postoperative phone calls by a physician affect outcomes in hand surgery.

Detailed description: This study seeks to determine if postoperative phone calls by a physician affect outcomes in hand surgery. Patients who require operative treatment of hand and wrist fractures are randomly assigned to a group that receives a postoperative phone call or the control group that receives the standard postoperative care. Patient reported and medical outcomes are observed starting at 1 month postoperatively.

Eligibility criteria: Inclusion Criteria:

* Patients with isolated injuries of the hand who present to a specific level 1 trauma center in the Midwestern United States
* Patients who have planned surgical treatment by a pre-specified group of surgeons

Exclusion Criteria:

* Patients who have significant trauma to other organ systems proximal to the wrist
* Patients who have open ("compound") fractures (i.e., bone is exposed)
* Children

Primary outcomes:
measure: Brief Michigan Hand Questionnaire Score Difference
timeFrame: 1 month postoperatively.
Secondary outcomes:
Other outcomes:
measure: Patient compliance with treatment recommendations
timeFrame: 1 month postoperatively
measure: Patient satisfaction with their overall care
timeFrame: 1 month postoperatively.
measure: Patient complication
timeFrame: 1 month postoperatively
Locations:
city: Indianapolis
country: United States
facility: Eskenazi Hospital
state: Indiana
Study officials:
affiliation: Indiana University School of Medicine
name: Joshua M Adkinson, M.D.
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT06093373: The Doppler Feasibility Study
Official title: Feasibility Study to Evaluate a New Hands-free Doppler Heart Rate Monitor Normally Used to Measure the Fetal Heart Rate
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Heart Rate Measurements
Lead sponsor: Sheffield Children's NHS Foundation Trust
Sponsor class: OTHER
Collaborators: name: Sheffield Hallam University
First posted: 2023-10-23
Enrollment: 11
Sex: ALL
Minimum age (years): 1
Maximum age (years): 12
Standard ages: CHILD
Accepts healthy volunteers: yes
Observational model: OTHER
Time perspective: OTHER
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Children aged 1-12 months admitted to the Sleep Unit at Sheffield Children's Hospital

Brief summary: The study is an exploratory research study looking at the feasibility, acceptability and accuracy of a doppler device compared with the gold standard ECG. It will take place in the sleep unit at Sheffield Children's Hospital.


Eligibility criteria: Inclusion Criteria:

* Patients who have been referred for a cardio-respiratory polygraphy sleep study.
* Patients aged one month up to one year old.

Exclusion Criteria:

* Subjects whose parents/legal guardians/carers are not fluent in English, or who have special communication needs.
* Child anticipated to become distressed with additional sensor.
* Child too clinically unwell to take part (as decided by clinical staff).

Primary outcomes:
measure: The accuracy of the system in 15 patients, when compared with the gold standard ECG
timeFrame: 1 hour
measure: The acceptability of the sensor to the child as viewed by the parent
timeFrame: 1 hour
Secondary outcomes:
Other outcomes:
Locations:
city: Sheffield
country: United Kingdom
facility: Clinical Research Facility, Sheffield Children's Hospital
Study officials:
References:
Clinical trial NCT06012773: Relationship Between Neck Posture and Stiffness of Head and Neck Muscles, Pain and Proprioception in Desk Workers
Official title: Investigation of the Relationship Between Neck Posture and Stiffness of Head and Neck Muscles, Pain and Proprioception in Desk Workers
Study type: OBSERVATIONAL
Overall status: ACTIVE_NOT_RECRUITING
Conditions: Work-Related Condition
Musculoskeletal Health
Keywords: proprioception
pain
neck posture
neck muscle stiffness
desk worker
Lead sponsor: Sanko University
Sponsor class: OTHER
First posted: 2023-08-25
Enrollment: 112
Sex: ALL
Minimum age (years): 18
Maximum age (years): 65
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: OTHER
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: Office workers

Brief summary: In our study, posture in desk workers; it aims to evaluate the relationship between cervical range of motion, proprioception, muscle stiffness, posture and pain.

Detailed description: One hundred twelve participants were included in the study.

Cervical range of motion and cervical proprioception were evaluated with a cervical range of motion (CROM) goniometer device, and muscle stiffness was evaluated with myotonometer device. Pain was evaluated with visual analog scale, and Migraine disability assessment scale (MIDAS) and Neck disability index.

Posture was evaluated with Posture Screen mobile application.

Eligibility criteria: Inclusion Criteria:

* Volunteer individuals aged 18-65
* Individuals using a computer in a sitting position at a desk

Exclusion Criteria:

* Individuals who have had serious traumatic injuries to the head, neck and shoulder area
* Individuals who have undergone any surgery on the head, neck and shoulder region
* Individuals with any anomaly in the head, neck and shoulder region

Primary outcomes:
measure: neck proprioception
timeFrame: 20 months
measure: Neck region muscle stiffness
timeFrame: 20 months
measure: Neck posture
timeFrame: 20 months
measure: Cervical range of motion
timeFrame: 20 months
Secondary outcomes:
measure: Head and neck pain
timeFrame: 20 months
Other outcomes:
Locations:
city: Gaziantep
country: Turkey
facility: SANKO University
Study officials:
affiliation: Sanko University
name: Meltem Uzun, PhD(c)
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT03011073: Evaluation of New Items in Cardiac Echography
Official title: Evaluation of New Items in Cardiac Echography
Study type: OBSERVATIONAL
Overall status: WITHDRAWN
Conditions: Cardiac Echography
Cardiac Ultrasound
Lead sponsor: Fondation Hôpital Saint-Joseph
Sponsor class: OTHER
First posted: 2017-01-05
Enrollment: 0
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: CASE_ONLY
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: All patient who have prescription to do an cardiac ultrasound

Brief summary: Paris Saint Joseph hospital has just acquired a new echocardiography EPIC . This new system has image processing and left ventricular function quantification software which are different from the precedent model Philips IE33.Left ventricular function quantification and myocardial distortion are the main medical examination influencing doctor's decisions.

EPIC can evaluate and quantify the cardiac ejection fraction via new software. Myocardial distortion quantification software also has been modified with new cut off and different calculation method.

The aim of this study is to compare the quality of images and the quantification of cardiac ejection fraction with these new software in order to choose the more reliable and reproducible for patient.


Eligibility criteria: Inclusion Criteria:

* patient accepting to stay 15 min more
* Age \> 18 years old

Exclusion Criteria:

* patient not accepting this procedure

Primary outcomes:
measure: Cardiac left ejection fraction
timeFrame: Day 1
Secondary outcomes:
measure: Echographic images evaluation
timeFrame: day 1
Other outcomes:
Locations:
Study officials:
References:
Clinical trial NCT00725673: Case Control Study: Determinants of Osteoporosis in GOLD II COPD Patients.
Official title: Determination of Risk Factors for Developing Osteoporosis in COPD GOLD II Patients. A Case Control Study to Identify Possible Risk Factors for Developing Osteoporosis in COPD GOLD II Patients.
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Chronic Obstructive Pulmonary Disease
Osteoporosis
Keywords: COPD
Osteoporosis
BMD
DEXA-scan
Lead sponsor: Catharina Ziekenhuis Eindhoven
Sponsor class: OTHER
First posted: 2008-07-30
Enrollment: 106
Sex: ALL
Minimum age (years): 40
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: CASE_CONTROL
Time perspective: CROSS_SECTIONAL
Sampling method: PROBABILITY_SAMPLE
Study population: GOLD II COPD patients (ATS and GOLD guidelines) visiting the outpatient clinic of pulmonary medicine of the Catharina Hospital Eindhoven.

Brief summary: Patients with COPD have been found to have an increased risk of osteoporosis. The underlying mechanism is not clear yet. This case control study aims to identify risk factors for osteoporosis in GOLD II COPD patients. COPD GOLD II patients with osteoporosis (cases) will be matched by gender and age to COPD GOLD II patients without osteoporosis(controls).

Possible risk factors for osteoporosis are:

* BMI/VVMI (body composition)
* emphysema vs chronic bronchitis
* physical capacity
* Use of certain medication (eg corticosteroids, SSRI's)
* Nutritional status
* Infectious parameters Outpatients from the pulmonary ward of the Catharina Hospital Eindhoven with GOLD II COPD according to the ATS and GOLD-guidelines will be included in the study (after written informed consent).

A DEXA-scan will be made, if patients are osteoporotic or have a normal BMD they will be included in the study.

A HRCT will be made, a six minutes walking distance will be performed, blood will be drawn for lab. analysis, an X-ray of the vertebral collum will be made, impedance will be measured and hight and weight will be measuered. Also patients will fill in a questionaire.

By univariate and multivariate analysis the collected data will be analysed to determine possible risk factors for th development of osteoporosis in COPD GOLD II patients.


Eligibility criteria: Inclusion Criteria:

* Age \>= 40 years
* GOLD II COPD
* Written permission

Exclusion Criteria:

* Age \< 40 years
* No COPD or COPD GOLD I, III or IV
* no written permission

Primary outcomes:
measure: Risk factors for osteoporosis in GOLD II COPD patients
timeFrame: 1 year
Secondary outcomes:
Other outcomes:
Locations:
city: Eindhoven
country: Netherlands
facility: Catharina Hospital Eindhoven
state: Noord-Brabant
Study officials:
affiliation: Catharina Ziekenhuis Eindhoven
name: Lidwien Graat-Verboom
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT05690373: Probiotics and Influenza Vaccination Response
Official title: Effects of Probiotics in Immune Response to Influenza Vaccination in Adults
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Vaccine Response
Keywords: vaccine response
seroconversion
antibody
Lead sponsor: The Archer-Daniels-Midland Company
Sponsor class: INDUSTRY
Collaborators: name: NIZO Food Research
First posted: 2023-01-19
Enrollment: 100
Sex: ALL
Minimum age (years): 16
Maximum age (years): 65
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: PREVENTION

Brief summary: Assess efficacy of oral ingestion of a probiotic product on immune function in a population of healthy adult men and women in a clinical vaccination study.


Eligibility criteria: Inclusion Criteria:

* Men and women
* Age 16 - 65 y and healthy
* Self-reported regular Dutch eating habits as assessed by questionnaire (3 main meals per day)
* No influenza vaccination in 2022
* Non-smokers
* BMI 18.5-28
* Adherence to habitual diet
* no changes during study period
* Signed informed consent

Exclusion Criteria:

* Recent vaccination
* Acute or chronic illness (e.g., diabetes mellitus)
* Gastrointestinal disorders (e.g., inflammatory bowel disease)
* Acute gastroenteritis in the past 2 months
* Immunodeficiency disorder
* Use of immunosuppressive drugs (e.g. cyclosporine, azathioprine, systemic corticosteroids, antibodies)
* Unexplained weight loss or weight gain of \> 3 kg in the 3 months prior to pre-study screening
* Alcohol or drug abuse
* Mental status that is incompatible with the proper conduct of the study
* History of cancer
* Use of immune boosting supplements within 4 weeks before screening To be extended \& specified in protocol phase

Primary outcomes:
measure: Seroconversion rate
timeFrame: From baseline to week 6
Secondary outcomes:
measure: Change in plasma cytokine levels
timeFrame: Baseline, week 2 and week 6
measure: Change in IgA antibodies against influenza
timeFrame: baseline, week 2, week 6
measure: Change in IgG antibodies against influenza
timeFrame: baseline, week 2, week 6
measure: Change in IgM antibodies against influenza
timeFrame: baseline, week 2, week 6
measure: Change in Gastrointestinal symptoms
timeFrame: baseline, week 2, week 6
measure: Change in Incidence of respiratory infections
timeFrame: baseline, week 2, week 6
Other outcomes:
Locations:
city: Ede
country: Netherlands
facility: Alwine Kardinaal, PhD NIZO food research B.V
Study officials:
affiliation: NIZO food research B.V
name: Alwine Kardinaal, PhD
role: STUDY_CHAIR
References:
Clinical trial NCT04685031: Ointment Therapy and Prevention of Cannulation-Induced Superficial Phlebitis
Official title: Ointment Therapy and Prevention of Cannulation-Induced Superficial Phlebitis
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: PHASE1
PHASE2
Conditions: Phlebitis
Keywords: Nitroglycerine
Clobetasol
phlebitis
Lead sponsor: Komar University of Science and Technology
Sponsor class: OTHER
First posted: 2020-12-28
Enrollment: 110
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: PREVENTION

Brief summary: The aim of this study was to determine the effect of Clobetasol ointment with nitroglycerin ointment on the prevention of superficial phlebitis caused by cannulation. This clinical trial was conducted on 110 patients admitted to the surgical ward, in three groups of Clobetasol, nitroglycerin, and control. The data collection tools included demographic information, information about intravenous treatment and phlebitis measurement scale. In the intervention groups, after venipuncture, 1.5 cm (about 2 g) of ointment was applied in the distal part of the Angio catheter and the site was dressed with sterile gauze. In three time periods of 24, 48 and 72 hours from the time of venipuncture.

Detailed description: Aim: The aim of this study was to determine the effect of clobetasol ointment with nitroglycerin ointment on the prevention of superficial phlebitis caused by cannulation.

Background: Today, more than 80 to 90% of hospitalized patients receive intravenous treatment during their treatment, and more than 500 million peripheral venous catheters are placed annually, although cannulation provide numerous benefits in clinical setting, but because of its invasive feature, it can end in unpleasant outcomes such as phlebitis Method: This clinical trial was conducted on 110 patients admitted to the surgical ward, in three groups of clobetasol, nitroglycerin, and control. The data collection tools included demographic information, information about intravenous treatment and phlebitis measurement scale. In the intervention groups, after venipuncture, 1.5 cm (about 2 g) of ointment was applied in the distal part of the Angio catheter and the site was dressed with sterile gauze. In three time periods of 24, 48 and 72 hours from the time of venipuncture.

Eligibility criteria: Inclusion Criteria:

* must be older than 18 years old
* must be in need of hospitalization at least 72 hours
* does not state any previous allergic reaction to the ointments
* does not use any types of drug that can hurts veins (chemotherapy drugs, diazepam. amiodarone, and....)

Exclusion Criteria:

* active infection
* discharge from hospital sooner than 72 hours
* displacement of cannula before 72 hours

Primary outcomes:
measure: Demographic information questionnaire
timeFrame: 72 hours
Secondary outcomes:
measure: The visual scale of phlebitis
timeFrame: 72hours
Other outcomes:
Locations:
Study officials:
References:
Clinical trial NCT04865731: Dermaprazole Cream for Radiation Dermatitis in Head and Neck Cancer
Official title: A Phase II Clinical Trial of Dermaprazole Cream for Radiation Dermatitis in Head and Neck Cancer Patients (CTMS# 20-0147)
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE2
Conditions: Cancer of the Head and Neck
Lead sponsor: The University of Texas Health Science Center at San Antonio
Sponsor class: OTHER
First posted: 2021-04-29
Enrollment: 6
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: In this study, the study team seek to conduct a pilot clinical study to evaluate the safety and efficacy of a reformulated proton pump inhibitor (PPI) cream (Dermaprazole) in definitive head and neck cancer (HNC) patients.


Eligibility criteria: Inclusion Criteria:

* Patients with head and neck malignancy (including radiation therapy to primary head cancers of any histology and/or neck lymphatics, excluding brain malignancies)
* Biopsy proven diagnosis of head and neck malignancy
* Planned to receive definitive chemoradiation of at least 66Gy
* Age 18 years or older
* Eastern Cooperative Oncology Group (ECOG) performance status 0 - 2
* Written Informed Consent
* History and Physical within 12 weeks of enrollment

Exclusion Criteria:

* Prior head and neck radiotherapy
* Neoadjuvant chemotherapy
* Any serious medical condition or illness that would preclude the safe administration of the trial treatment including, but not limited to, active infection, symptomatic heart failure, unstable angina, psychiatric illness or social situations that would limit compliance with treatment
* Currently taking proton pump inhibitors. Eligible if discontinues with physician approval.
* Lack of concurrent chemotherapy
* Open wound at time of simulation
* Known autoimmune, connective tissue, or skin disorder; or other theoretical radiosensitivity to include bullous pemphigoid, dermatomyositis, lupus of the skin and scleroderma

Primary outcomes:
measure: Rates of clinically significant radiation dermatitis as defined as NCI CTCAE version 5 grade 2 or higher
timeFrame: 15 months
Secondary outcomes:
Other outcomes:
Locations:
city: San Antonio
country: United States
facility: Mays Cancer Center
state: Texas
Study officials:
affiliation: The University of Texas Health Science Center - Mays Cancer Center
name: Shraddha Dalwadi, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT01182831: Trial Comparing Two Techniques of Celiac Plexus Neurolysis for Treatment of Pain in Carcinoma Pancreas
Official title: A Randomized Trial Comparing Fluoroscopy Guided Percutaneous Technique Versus Endoscopic Ultrasound Guided Technique of Celiac Plexus Neurolysis for Treatment of Pain in Carcinoma Pancreas
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: PHASE1
Conditions: Pancreatic Cancer
Keywords: carcinoma pancreas
percutaneous celiac plexus neurolysis
endosonography guided celiac plexus neurolysis
Lead sponsor: Asian Institute of Gastroenterology, India
Sponsor class: OTHER
First posted: 2010-08-17
Enrollment: 100
Sex: ALL
Minimum age (years): 18
Maximum age (years): 75
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: Coeliac plexus neurolysis (CPN) is a management option for pain control in carcinoma pancreas.CPN is conventionally performed by percutaneous technique with fluoroscopic guidance. Endoscopic ultrasound (EUS) is increasingly used for CPN as it offers a better visualization of the plexus. There are limited data comparing the two modalities.The patients are on follow-up for 6 months post neurolysis.

Detailed description: Carcinoma pancreas patients with abdominal pain requiring daily analgesics for more than 4 weeks were included.we are randomising about 100 patients into two groups to undergo either of the two procedures, i.e. celiac plexus neurolysis by percutaneous technique or by endoscopic ultrasound guided technique.The pain scores have been recorded by visual analogue scale for an average follow-up of 6 months.

Eligibility criteria: Inclusion Criteria:

* all patients with carcinoma pancreas

Exclusion Criteria:

* patients below 18 years of age and who have not given consent

Primary outcomes:
measure: immediate pain relief
timeFrame: day of block to six months of follow-up
Secondary outcomes:
Other outcomes:
Locations:
city: Hyderabad
country: India
facility: Asian Institute of Gastroenterology
state: Andhra pradesh
Study officials:
References: