Clinical trial NCT06302296: Evaluating the Effect of Injectable Platelet-rich Fibrin on Accelerating Orthodontic Tooth Movement
Official title: Evaluating the Effect of Injectable Platelet-rich Fibrin on Accelerating Orthodontic Tooth Movement During Leveling and Alignment Stage Study Description
Study type: INTERVENTIONAL
Overall status: RECRUITING
Phase: NA
Conditions: Tooth Mobility
Injectable Platelet-rich Fibrin
Lead sponsor: Hama University
Sponsor class: OTHER
First posted: 2024-03-08
Enrollment: 14
Sex: ALL
Minimum age (years): 18
Maximum age (years): 26
Standard ages: ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: One of the main goals of orthodontic treatment is the reduction of treatment time through faster tooth movement. The previous studies evaluating platelet-rich fibrin (PRF) and orthodontic tooth movement (OTM) are limited, which makes the results difficult to generalize.

Detailed description: One of the main goals of orthodontic treatment is the reduction of treatment time through faster tooth movement. The previous studies evaluating platelet-rich fibrin (PRF) and orthodontic tooth movement (OTM) are limited, which makes the results difficult to generalize. To this end, we set up this Randomized experiment to evaluate the effect of the injectable form of PRF (i-PRF) on OTM, using nonadditive containing i-PRF, which has higher levels of regenerative cells and growth factors compared with other PRF types because of the use of low centrifugation spee. Accordingly, we aimed to evaluate the effect of i-PRF on the rate of maxillary incisors leveling during comprehensive orthodontic treatment.

Eligibility criteria: Inclusion Criteria:

* The patient's age (18-26). Severe or very severe irregularity of the upper incisors greater than (7 mm) according to Little's index, so it is recommended to extract the upper first premolar.

  * Class I or Class II malocclusion, first model according to Angle, with skeletal class I or II and a normal or mild vertical growth pattern.
  * All permanent upper teeth, up to the first molar, are present, with the possibility of attaching brackets to all teeth in a correct position.
  * The patient has good oral health.

Exclusion Criteria:

* • The presence of any systemic disease that affects orthodontic dental movement.

  * Severe malalignment of one of the teeth (palatal quadrant, ectopic canine, ectopic premolar).
  * The patient has undergone previous orthodontic treatment.
  * The patient is subject to any drug treatment that may affect orthodontic dental movement (cortisone, non-steroidal anti-inflammatory drugs).
  * The patient has poor oral health.
  * Commitment to periodic follow-up appointments.

Primary outcomes:
measure: Leveling and alignment maxillary incisors
timeFrame: One month ,two month,six month
Secondary outcomes:
Other outcomes:
Locations:
city: Hama
country: Syrian Arab Republic
facility: Fadi Jnaid
Study officials:
affiliation: Hama University
name: Eisa Salami, MSc student
role: PRINCIPAL_INVESTIGATOR
affiliation: Hama University
name: Rabab Alsabbagh, Professor
role: STUDY_CHAIR
References: