Clinical trial NCT05362175: Cross Sectional Area of Umbilical Cord Versus Hadlock's Formula in Prediction of Neonatal Birth Weight
Official title: Comparison of the Efficacy Between Ultrasound Measurement of Cross Sectional Area of the Umbilical Cord and Hadlock's Formula in Prediction of Neonatal Birth Weight at Term Gestation:Cross Sectional Study
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Birth Weight
Fetal Body Weight
Keywords: Birth weight
Hadlock's formula
Cross sectional area of umbilical cord
Umbilical cord
Fetal biometry
Lead sponsor: Ain Shams University
Sponsor class: OTHER
First posted: 2022-05-05
Enrollment: 220
Sex: FEMALE
Minimum age (years): 18
Maximum age (years): 35
Standard ages: ADULT
Accepts healthy volunteers: yes
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: Pregnant women at term gestation admitted at labor room or prepared for cesarean section

Brief summary: Ultrasound measurement of cross sectional area of umbilical cord might offer advantage over Hadlock's formula for accurate estimation of actual birth weight at term gestation leading to prevention of large number of maternal and neonatal morbidity and mortality.

Detailed description: Umbilical cord is a vital structure of maternal-fetal life that can be used to evaluate pregnancy outcomes. In the past, sonographic investigations of the umbilical cord were limited to identification of the number of vessels and Doppler evaluation of the blood flow. Various formulas have developed to calculate Estimated Fetal Weight (EFW) using fetal biometry. While it is being accurate to a degree, they are associated with error especially with extreme birth weight. In this study using the ultrasound to look for a relation between the umbilical cord cross sectional area and estimated birth weight, as it's easy to use and readily available, comparing the estimated birth weight obtained by this method with that of Hadlock's formula measures at term gestation. Trying to prove that the umbilical cord area formula might gave advocacy for future usage for birth weight prediction.

Eligibility criteria: Inclusion Criteria:

* Pregnant women with:

  * Age: 18-35 years.
  * Singleton living fetus.
  * Term gestation (37wks_ 41wks+6days). (Spong , 2013).
  * Admitted at labor room or prepared for caesarean section

Exclusion Criteria:

* o Intrauterine Dead fetus (IUFD).

  * Structurally malformed fetus or umbilical cord (single umbilical artery; SUA).
  * Multiple pregnancies.
  * Oligohydraminos (AFI \< 5cm or DVP \<2 cm) or polyhydraminos (AFI \> 25 cm or DVP \> 8 cm) (Morteza et al., 2018).
  * Uterine fibroid.
  * Abnormal Doppler flowmetry of umbilical artery.
  * Maternal diseases (Diabetes mellitus, Hypertensive disorders, renal diseases, Ischemic heart diseases), history of drug intake (Antihypertensive, antiepileptic, oral hypoglycemic drugs).

Primary outcomes:
measure: Estimated fetal weight calculation by hadlock's formula and by umbilical cord cross sectional area ,then correlation with actual birth weight measured with in 1st hour of delivary
timeFrame: 1st hour of delivary
Secondary outcomes:
Other outcomes:
Locations:
city: Cairo
country: Egypt
facility: Ain Shams university
Study officials:
References: