Clinical trial NCT00152659: Developing Criteria for Cortical Resections
Official title: Developing Functional and Structural Criteria for Cortical Resections
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Epilepsy
Tumor
Keywords: Epilepsy
Tumor
Surgery
Brain
Lead sponsor: University of Chicago
Sponsor class: OTHER
First posted: 2005-09-09
Enrollment: 87
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: OTHER
Time perspective: RETROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Surgical candidates with epilepsy or brain tumor(s)

Brief summary: The purpose of this study is to study how disease processes like tumors or epilepsy spread in the brain.

Detailed description: The purpose of this study is to study how disease processes like tumors or epilepsy spread in the brain. During surgery small pieces of abnormal (unusual) brain tissue may be removed. We analyze these specimens using more advanced microscopic and electrophysiologic techniques than are usually applied to such tissue specimens. In addition, some tissues can be maintained in laboratory conditions to allow analysis over the longer term. No extra brain tissue is taken to perform these studies. The tissue analysis is performed by the research team and are compared to the routine (normal) electrical recordings that are taken during this type of brain surgery. Currently there are no instructions telling a doctor how much brain tissue should be cut out to prevent the spread of tumors or epilepsy. We are hoping that the results of this study help us to better know how much brain tissue needs to be removed to prevent the spread of tumors or epilepsy.

Eligibility criteria: Inclusion Criteria:

* Surgical candidates with epilepsy or brain tumor(s)

Primary outcomes:
measure: measure electrical activity in tissue sample
timeFrame: at tissue aremoval time
Secondary outcomes:
Other outcomes:
Locations:
city: Chicago
country: United States
facility: The University of Chicago Hospitals, The University of Chicago Comer Children's Hospital
state: Illinois
Study officials:
affiliation: University of Chicago
name: Wim van Drongelen, Ph.D.
role: PRINCIPAL_INVESTIGATOR
References:
citation: Ramirez J-M, Koch H, Pena F, Drongelen W van, Tryba AK, Parkis MA, Loweth JA, Hecox KE, Kohrman MH, Frim DM, Chico MS, Marcuccilli CJ (2003) - In vitro electrophysiological differences between least and most abnormal tissue obtained from pediatric patients with intractable epilepsy. Epilepsia 44, Suppl 9: 245-246
citation: Marcuccilli CJ, Koch H, Pena F, Drongelen W van, Tryba AK, Parkis MA, Hecox KE, Kohrman MH, Frim DM, OConnor SE, Chico MS, Ramirez J-M (2003) - Rational pharmacotherapy: relationship between in vitro electrophysiology and clinical measures. Epilepsia 44, Suppl 9: 244-245
citation: Drongelen W van, Koch H, Marcuccilli CJ, Viemari J, Tryba AKH, Loweth JA, Ramirez J-M, Elsen F (2004) - Persistent sodium current plays a critical role in the generation of slow oscillations in vitro neocortex brain slices of mice and humans. Abstract Soc Neuroscience
citation: Drongelen W van, Doren EL, Koch H, Marcuccilli CJ, Ramirez J-M, Elsen FP (2005) - Characterization of the persistent sodium current in neocortical networks of mice and humans. Abstract Washington DC: Society for Neuroscience