Clinical trial NCT04926935: Bloodstram Infections in ICU. Single Centre Observational Study.
Official title: Bloodstram Infections in Intensive Care Unit. A Single Centre Bacteriological Analysis Between 2007-2019.
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Bloodstream Infection
Antibiotic Resistant Strain
Intensive Care Unit
Lead sponsor: Military Institute od Medicine National Research Institute
Sponsor class: OTHER
First posted: 2021-06-15
Enrollment: 3502
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: All patients hospitalized in the ICU with clinically suspected infection between 2007-2019.

Brief summary: Hospital-acquired bloodstream infection (BSI) is serious care problem worldwide associated with significant morbidity and mortality. However, only few nationwide studies have focused on the incidence of BSI, and its results were often inconsistent.

The objective of this study was to analyze bloodstream infections in patients hospitalized in the intensive care unit of the tertiary, university hospital. Special attention was put on the etiology of the infections, the antimicrobial susceptibility/resistance of the isolated pathogens, as well as the incidence of central vein catheters infections in the analyzed population.

Data were collected in the intensive care unit of the Military Institute of Medicine, Warsaw, Poland, between January, 1, 2007 and December, 31, 2019.


Eligibility criteria: Inclusion Criteria:

* all patients hospitalized in the ICU with clinically suspected infection.

Exclusion Criteria:

* none.

Primary outcomes:
measure: Results of microbiological analysis.
timeFrame: After completion of the microbiological analysis, up to 72 hours.
measure: Isolated pathogens' susceptibility for antimicrobial agents. .
timeFrame: After completion of the microbiological analysis, up to 72 hours.
measure: Isolated pathogens' resistance for antimicrobial agents. .
timeFrame: After completion of the microbiological analysis, up to 72 hours.
Secondary outcomes:
Other outcomes:
Locations:
city: Warsaw
country: Poland
facility: Department of Anesthesiology and Intensive Therapy
Study officials:
affiliation: Military Institute od Medicine National Research Institute
name: Dariusz Tomaszewski, MD, PhD
role: PRINCIPAL_INVESTIGATOR
References:
citation: Garrouste-Orgeas M, Timsit JF, Tafflet M, Misset B, Zahar JR, Soufir L, Lazard T, Jamali S, Mourvillier B, Cohen Y, De Lassence A, Azoulay E, Cheval C, Descorps-Declere A, Adrie C, Costa de Beauregard MA, Carlet J; OUTCOMEREA Study Group. Excess risk of death from intensive care unit-acquired nosocomial bloodstream infections: a reappraisal. Clin Infect Dis. 2006 Apr 15;42(8):1118-26. doi: 10.1086/500318. Epub 2006 Mar 14.
citation: Laupland KB, Lee H, Gregson DB, Manns BJ. Cost of intensive care unit-acquired bloodstream infections. J Hosp Infect. 2006 Jun;63(2):124-32. doi: 10.1016/j.jhin.2005.12.016. Epub 2006 Apr 18.
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citation: de Kraker ME, Jarlier V, Monen JC, Heuer OE, van de Sande N, Grundmann H. The changing epidemiology of bacteraemias in Europe: trends from the European Antimicrobial Resistance Surveillance System. Clin Microbiol Infect. 2013 Sep;19(9):860-8. doi: 10.1111/1469-0691.12028. Epub 2012 Oct 8.
citation: Goto M, Al-Hasan MN. Overall burden of bloodstream infection and nosocomial bloodstream infection in North America and Europe. Clin Microbiol Infect. 2013 Jun;19(6):501-9. doi: 10.1111/1469-0691.12195. Epub 2013 Mar 8.