Clinical trial NCT05097937: Analgesic Mechanisms of Percutaneous Electrolysis
Official title: Neurophysiological Effects of Percutaneous Electrolysis Related to Endogenous Pain Modulation
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Percutaneous Electrolysis
Pain
Analgesia
Pain Modulation
Endogenous Analgesia System
Lead sponsor: University of Salamanca
Sponsor class: OTHER
First posted: 2021-10-28
Enrollment: 54
Sex: ALL
Minimum age (years): 18
Maximum age (years): 40
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: BASIC_SCIENCE

Brief summary: Percutaneous electrolysis is based on the application of a galvanic current through an acupuncture needle. The underlying mechanisms that explain the efficacy of this technique are not completely well understood. The objective is to delve into the neurophysiological analgesic effects of percutaneous electrolysis. Participants will be assigned to one of three intervention groups. The analgesic effects of the technique will be evaluated by means of variables related to endogenous pain modulation.


Eligibility criteria: Inclusion Criteria:

* Asymptomatic subjects
* Signature of the informed consent

Exclusion Criteria:

* Fear of needles
* Any pathology or process that causes pain
* Neurological, rheumatologic, cardiovascular or metabolic diseases
* Cutaneous alterations and cognitive or sensitivity disorders
* Pregnancy
* Recent intake of alcohol or caffeine
* Vigorous physical activity on the day of testing

Primary outcomes:
measure: Changes from baseline in Pressure Pain Thresholds (PPT)
timeFrame: Baseline and immediately after the intervention
Secondary outcomes:
measure: Changes from baseline in Conditioned Pain Modulation (CPM)
timeFrame: Baseline and immediately after the intervention
measure: Changes from baseline in Temporal Summation (TS)
timeFrame: Baseline and immediately after the intervention
Other outcomes:
Locations:
city: Salamanca
country: Spain
facility: Facultad de Enfermería y Fisioterapia de la Universidad de Salamanca
Study officials:
References:
citation: de Miguel Valtierra L, Salom Moreno J, Fernandez-de-Las-Penas C, Cleland JA, Arias-Buria JL. Ultrasound-Guided Application of Percutaneous Electrolysis as an Adjunct to Exercise and Manual Therapy for Subacromial Pain Syndrome: A Randomized Clinical Trial. J Pain. 2018 Oct;19(10):1201-1210. doi: 10.1016/j.jpain.2018.04.017. Epub 2018 May 16.
citation: Garcia Bermejo P, De La Cruz Torres B, Naranjo Orellana J, Albornoz Cabello M. Autonomic Responses to Ultrasound-Guided Percutaneous Needle Electrolysis: Effect of Needle Puncture or Electrical Current? J Altern Complement Med. 2018 Jan;24(1):69-75. doi: 10.1089/acm.2016.0339. Epub 2017 Jan 30.
citation: Cagnie B, Dewitte V, Barbe T, Timmermans F, Delrue N, Meeus M. Physiologic effects of dry needling. Curr Pain Headache Rep. 2013 Aug;17(8):348. doi: 10.1007/s11916-013-0348-5.
citation: Abat F, Valles SL, Gelber PE, Polidori F, Stitik TP, Garcia-Herreros S, Monllau JC, Sanchez-Ibanez JM. [Molecular repair mechanisms using the Intratissue Percutaneous Electrolysis technique in patellar tendonitis]. Rev Esp Cir Ortop Traumatol. 2014 Jul-Aug;58(4):201-5. doi: 10.1016/j.recot.2014.01.002. Epub 2014 May 10. Spanish.
citation: Abat F, Gelber PE, Polidori F, Monllau JC, Sanchez-Ibanez JM. Clinical results after ultrasound-guided intratissue percutaneous electrolysis (EPI(R)) and eccentric exercise in the treatment of patellar tendinopathy. Knee Surg Sports Traumatol Arthrosc. 2015 Apr;23(4):1046-52. doi: 10.1007/s00167-014-2855-2. Epub 2014 Jan 30.
citation: Yarnitsky D, Bouhassira D, Drewes AM, Fillingim RB, Granot M, Hansson P, Landau R, Marchand S, Matre D, Nilsen KB, Stubhaug A, Treede RD, Wilder-Smith OH. Recommendations on practice of conditioned pain modulation (CPM) testing. Eur J Pain. 2015 Jul;19(6):805-6. doi: 10.1002/ejp.605. Epub 2014 Oct 20.