Clinical trial NCT06791200: Role of Some Biochemical Indices for Prediction of Acute Kidney Injury in Intensive Care Unit Patients in Upper Egypt
Official title: Role of Some Biochemical Indices for Prediction of Acute Kidney Injury in Intensive Care Unit Patients in Upper Egypt
Study type: OBSERVATIONAL
Overall status: NOT_YET_RECRUITING
Conditions: Acute Kidney Injury
Lead sponsor: Assiut University
Sponsor class: OTHER
First posted: 2025-01-24
Enrollment: 100
Sex: ALL
Minimum age (years): 16
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: The selected patients will be with the following inclusion criteria:

Patients admitted to ICU within 24 hours

Brief summary: 1. We will investigate the relation between the triglyceride-glucose index and the development of AKI in ICU.
2. To detect whether the TGI is a predictor of poor outcome (requirement of renal replacement therapy, or 14-day in-hospital mortality, and length of hospital stay) in ICU.
3. Compare TGL, Neutrophil-to-lymphocyte ratio, and clinical score (sequential organ failure assessment SOFA score) as predictors of poor outcome in ICU.

Detailed description: Acute kidney injury (AKI) is a common clinical syndrome with a broad aetiological profile. It complicates about 5% of hospital admissions and 30% of admissions to intensive care units (ICU). During last 20 years has been a significant change in the spectrum of severe AKI such that it is no longer mostly a single organ phenomenon but rather a complex multisystem clinical problem. mortality from AKI, when part of MOF, remains over 50%.

In the past few decades, the understanding of AKI has greatly improved, but early diagnosis remains a great challenge. The performance of traditional kidney function index and serum creatinine is very limited for the early diagnosis of acute kidney injury The triglyceride glucose index (TGI) has been suggested as a useful marker of insulin resistance. Previous studies have shown that TGI is associated with many diseases, but no study has examined the relationship between TGI and Aki .

the primary objective of the present study was to investigate the relationship between TGI and Aki.

Eligibility criteria: Inclusion Criteria:

* The selected patients will be with the following inclusion criteria:

Patients admitted to ICU within 24 hours

Exclusion Criteria:

* We will exclude those with any of the following:

  1. Patients diagnosed more than 24 hours.
  2. Patients with missing data of triglyceride or glucose.
  3. Patients \&amp;amp;lt;18years old.
  4. patient with advanced liver disease and chronic kidney disease with or without dialysis

Primary outcomes:
measure: TGI
timeFrame: baseline
Secondary outcomes:
Other outcomes:
Locations:
city: اسيوط
country: Egypt
facility: جامعة اسيوط
Study officials:
affiliation: Assiut University
name: Dr. Taghreed Sayed Mohamed Meshref s Meshref, Lecturer of Critical care med
role: STUDY_DIRECTOR
References:
citation: Birkelo BC, Pannu N, Siew ED. Overview of Diagnostic Criteria and Epidemiology of Acute Kidney Injury and Acute Kidney Disease in the Critically Ill Patient. Clin J Am Soc Nephrol. 2022 May;17(5):717-735. doi: 10.2215/CJN.14181021. Epub 2022 Mar 15.