Clinical trial NCT06257875: A Study to Assess Adverse Events and Change in Disease Activity From Intravenous (IV) and Subcutaneous (SC) Lutikizumab in Adult Participants With Active Ulcerative Colitis
Official title: A Multicenter, Randomized Study to Evaluate the Safety and Efficacy of Lutikizumab for Induction and Maintenance Therapy in Subjects With Moderately to Severely Active Ulcerative Colitis
Study type: INTERVENTIONAL
Overall status: RECRUITING
Phase: PHASE2
Conditions: Ulcerative Colitis
Keywords: Ulcerative Colitis
Lutikizumab
Adalimumab
Lead sponsor: AbbVie
Sponsor class: INDUSTRY
First posted: 2024-02-14
Enrollment: 200
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: SEQUENTIAL
Primary purpose: TREATMENT

Brief summary: Ulcerative colitis (UC) is a type of inflammatory bowel disease that causes inflammation and bleeding from the lining of the rectum and colon (large intestine). The purpose of this study is to assess how safe and effective lutikizumab is in adult participants with moderate to severe UC and how lutikizumab compares to adalimumab in the treatment of UC. Adverse events and changes in disease activity will be assessed.

Lutikizumab is an investigational product being developed for the treatment of moderate to severe UC. Participants are placed in groups called treatment arms. Each group receives a different treatment. In the Induction Period, participants will be randomized into 1 of 3 arms receiving lutikizumab Dose 1, lutikizumab Dose 2, or adalimumab. In the Maintenance Period, participants who responded to lutikizumab will be randomized into 1 of 2 arms of lutikizumab maintenance and participants who responded to adalimumab will continue to receive adalimumab. All participants who did not achieve clinical response per modified Mayo Score at the end of the Induction period will receive open label lutikizumab. Around 200 adult participants with UC will be enrolled at approximately 280 sites worldwide.

During the 12 week Induction Period, participants will be randomized to receive intravenous (IV) and subcutaneous (SC) lutikizumab or SC adalimumab. At the 12 week mark, participants who are on lutikizumab who have responded to treatment will be re-randomized to receive SC lutikizumab at different intervals until Week 52. Participants who are on adalimumab who are responding to treatment will continue to receive adalimumab. Participants who do not respond to treatment will receive open-label SC lutikizumab. Participants who complete the Week 52 visit and in whom therapeutic benefit to study drug is confirmed by the investigator may roll over into an optional, blinded 52-week long-term extension (LTE).

There may be higher treatment burden for participants in this trial compared to their standard of care. Participants will attend regular visits during the study at a hospital or clinic. The effect of the treatment will be checked by medical assessments, blood tests, checking for side effects and completing questionnaires.


Eligibility criteria: Inclusion Criteria:

* Participant has had a diagnosis of Ulcerative Colitis (UC) for at least 90 days prior to Baseline. Appropriate documentation of biopsy results consistent with the diagnosis of UC in the assessment of the investigator, must be available.
* Active UC with a Modified Mayo Score (mMS) of 5 to 9 points and Mayo Endoscopic Subscore (ESS) of 2 to 3 (confirmed by central review).
* Demonstrated inadequate response to, loss of response to, or intolerance to at least one of the following: oral aminosalicylates, corticosteroids, immunomodulators, and/or advanced therapies.

Exclusion Criteria:

* Current diagnosis of Crohn's Disease (CD) or inflammatory bowel disease-unclassified.
* Extent of inflammatory disease limited to the rectum as assessed by screening endoscopy.
* Prior inadequate response, intolerance or loss of response to adalimumab (including biosimilars). Note: Participant may be enrolled if he/she discontinued adalimumab for reasons other than those listed above (e.g., loss of insurance) or he/she has been exposed to other advanced therapies, including anti-TNFs other than adalimumab.

Primary outcomes:
measure: Percentage of Participants who Achieve Endoscopic Improvement
timeFrame: Week 12
measure: Number of Participants with Adverse Events (AEs)
timeFrame: Up to approximately Week 64
Secondary outcomes:
measure: Percentage of Participants who Achieve Clinical Remission Per Modified Mayo Score (mMS)
timeFrame: Week 12
measure: Percentage of Participants who Achieve Clinical Response Per mMS
timeFrame: Week 12
measure: Percentage of Participants who Achieve Endoscopic Remission
timeFrame: Week 12
Other outcomes:
Locations:
city: Chula Vista
country: United States
facility: Gastro SB /ID# 258331
state: California
city: Coronado
country: United States
facility: Southern California Res. Ctr. /ID# 258391
state: California
city: Huntington Beach
country: United States
facility: Newport Huntington Medical Group /ID# 258371
state: California
city: Lancaster
country: United States
facility: Om Research LLC /ID# 261383
state: California
city: Orange
country: United States
facility: UC Irvine Health /ID# 259824
state: California
city: Aurora
country: United States
facility: University of Colorado Hospital /ID# 258388
state: Colorado
city: Coral Gables
country: United States
facility: Research Associates of South Florida, LLC /ID# 259813
state: Florida
city: Gainesville
country: United States
facility: University of Florida College of Medicine /ID# 260402
state: Florida
city: Lakeland
country: United States
facility: Auzmer Research /ID# 260940
state: Florida
city: Margate
country: United States
facility: Atlantic Medical Research /ID# 258507
state: Florida
city: Miami
country: United States
facility: Homestead Associates in Research /ID# 260392
state: Florida
city: Miami
country: United States
facility: University of Miami /ID# 258396
state: Florida
city: Miami
country: United States
facility: JD Medical Group, LLC /ID# 261235
state: Florida
city: Naples
country: United States
facility: Gastroenterology Group Naples /ID# 258346
state: Florida
city: Orlando
country: United States
facility: AdventHealth Medical Group Blood & Marrow Transplant at Orlando /ID# 260945
state: Florida
city: Tampa
country: United States
facility: GCP Clinical Research, LLC /ID# 260401
state: Florida
city: Decatur
country: United States
facility: Atlanta Ctr. for Gastro /ID# 259275
state: Georgia
city: Macon
country: United States
facility: Gastroenterology Associates of Central Georgia, LLC /ID# 258359
state: Georgia
city: Roswell
country: United States
facility: Gastroenterology Consultants, P.C /ID# 258352
state: Georgia
city: Chicago
country: United States
facility: The University of Chicago DCAM /ID# 258491
state: Illinois
city: Indianapolis
country: United States
facility: IU Health University Hospital /ID# 260398
state: Indiana
city: Kansas City
country: United States
facility: Univ Kansas Med Ctr /ID# 258489
state: Kansas
city: Shreveport
country: United States
facility: Louisiana Research Center, LLC /ID# 258330
state: Louisiana
city: Chesterfield
country: United States
facility: Clin Res Inst of Michigan, LLC /ID# 258386
state: Michigan
city: Chesterfield
country: United States
facility: Clin Res Inst of Michigan, LLC /ID# 259267
state: Michigan
city: Wyoming
country: United States
facility: Gastroenterology Associates of Western Michigan, PLC d.b.a. West Michigan Clinic /ID# 258493
state: Michigan
city: Rochester
country: United States
facility: Mayo Clinic - Rochester /ID# 258402
state: Minnesota
city: Albuquerque
country: United States
facility: Univ New Mexico /ID# 258490
state: New Mexico
city: Brooklyn
country: United States
facility: NY Scientific /ID# 260937
state: New York
city: Lake Success
country: United States
facility: NYU Langone Long Island Clinical Research Associates /ID# 258504
state: New York
city: New York
country: United States
facility: Weill Cornell Medicine/NYP /ID# 258953
state: New York
city: New York
country: United States
facility: Columbia University Medical Center /ID# 258496
state: New York
city: Charlotte
country: United States
facility: Atrium Health /ID# 258506
state: North Carolina
city: Charlotte
country: United States
facility: DJL Clinical Research, PLLC /ID# 259465
state: North Carolina
city: Winston-Salem
country: United States
facility: Atrium Health Wake Forest Baptist Medical Center /ID# 260387
state: North Carolina
city: Fargo
country: United States
facility: Plains Clinical Research Center, LLC /ID# 258502
state: North Dakota
city: Oklahoma City
country: United States
facility: Digestive Disease Specialists /ID# 258499
state: Oklahoma
city: Garland
country: United States
facility: Digestive Health Associates of Texas (DHAT) Research Institute - Garland /ID# 258358
state: Texas
city: Houston
country: United States
facility: Baylor College of Medicine /ID# 258394
state: Texas
city: Houston
country: United States
facility: BioStar Clinical Research Group - Houston - Katy Freeway /ID# 261164
state: Texas
city: San Antonio
country: United States
facility: Clinical Associates in Research Therapeutics of America, LLC /ID# 258403
state: Texas
city: San Antonio
country: United States
facility: Southern Star Research Institute, LLC /ID# 258347
state: Texas
city: Tyler
country: United States
facility: Tyler Research Institute, LLC /ID# 258383
state: Texas
city: Webster
country: United States
facility: Texas Digestive Disease Consultants - Webster /ID# 258718
state: Texas
city: Huntington
country: United States
facility: University Physicians and Surgeons Inc. /ID# 260399
state: West Virginia
city: Milwaukee
country: United States
facility: Wisconsin Center for Advanced Research /ID# 258949
state: Wisconsin
city: Bankstown
country: Australia
facility: Bankstown-Lidcombe Hospital /ID# 259089
state: New South Wales
city: Elizabeth Vale
country: Australia
facility: Lyell McEwin Hospital /ID# 260580
state: South Australia
city: Woodville South
country: Australia
facility: The Queen Elizabeth Hospital /ID# 259482
state: South Australia
city: Fitzroy Melbourne
country: Australia
facility: St Vincent's Hospital Melbourne /ID# 259473
state: Victoria
city: Murdoch
country: Australia
facility: Fiona Stanley Hospital /ID# 259480
state: Western Australia
city: Sankt Poelten
country: Austria
facility: Universitaetsklinikum St. Poelten /ID# 258256
state: Niederoesterreich
city: Anderlecht
country: Belgium
facility: Universite Libre de Bruxelles - Hopital Erasme /ID# 258214
state: Bruxelles-Capitale
city: Liège
country: Belgium
facility: CHU de Liège /ID# 258212
state: Liege
city: Gent
country: Belgium
facility: UZ Gent /ID# 258210
state: Oost-Vlaanderen
city: Sint-Niklaas
country: Belgium
facility: Vitaz /Id# 258222
state: Oost-Vlaanderen
city: Leuven
country: Belgium
facility: Universitair Ziekenhuis Leuven /ID# 258226
state: Vlaams-Brabant
city: Gent
country: Belgium
facility: AZ Maria Middelares /ID# 258219
city: Sofiya
country: Bulgaria
facility: Hospital Tsaritsa Yoanna /ID# 258338
state: Sofia
city: Sofiya
country: Bulgaria
facility: Medical Center - Doverie /ID# 261936
state: Sofia
city: Sofiya
country: Bulgaria
facility: ACIBADEM City Clinic Diagnostic-Consultative Center /ID# 258339
state: Sofia
city: Plovdiv
country: Bulgaria
facility: Umbal Kaspela /ID# 258336
city: Sofia
country: Bulgaria
facility: 2nd Mhat /ID# 258337
city: Sofia
country: Bulgaria
facility: UMHAT Sveti Ivan Rilski /ID# 261417
city: Varna
country: Bulgaria
facility: University Multiprofile Hospit /ID# 258878
city: Edmonton
country: Canada
facility: Gastroenterology and Internal Medicine Research Institution /ID# 258765
state: Alberta
city: Edmonton
country: Canada
facility: Covenant Health /ID# 258799
state: Alberta
city: Vaughan
country: Canada
facility: Toronto Digestive Disease Associates /ID# 260460
state: Ontario
city: Zagreb
country: Croatia
facility: Klinicki bolnicki centar Zagreb /ID# 258145
state: Grad Zagreb
city: Zagreb
country: Croatia
facility: Poliklinika Solmed /ID# 258147
state: Grad Zagreb
city: Osijek
country: Croatia
facility: POLIKLINIKA BORZAN d.o.o. /ID# 258146
state: Osjecko-baranjska Zupanija
city: Split
country: Croatia
facility: Klinicki Bolnicki Centar (KBC) Split /ID# 258153
state: Splitsko-dalmatinska Zupanija
city: Rijeka
country: Croatia
facility: Specijalna bolnica Medico Rijeka /ID# 258169
city: Tallinn
country: Estonia
facility: West Tallinn Central Hospital /ID# 262035
state: Harjumaa
city: Tallinn
country: Estonia
facility: Medicum /ID# 268320
state: Harjumaa
city: Parnu
country: Estonia
facility: Parnu Hospital /ID# 261783
city: Tartu
country: Estonia
facility: Tartu University Hospital /ID# 261782
city: Nice
country: France
facility: Chu de Nice-Hopital L'Archet Ii /Id# 258041
state: Alpes-Maritimes
city: Toulouse
country: France
facility: CHU Toulouse - Hopital Rangueil /ID# 258044
state: Haute-Garonne
city: St-Priest-en-Jarez
country: France
facility: Centre Hospitalier Universitaire de Saint Etienne - Hopital Nord /ID# 258040
state: Loire
city: Creteil
country: France
facility: Hopitaux Universitaires Henri Mondor - Hopital Henri Mondor /ID# 258555
state: Paris
city: Nantes
country: France
facility: CHU de Nantes, Hotel Dieu -HME /ID# 258042
state: Pays-de-la-Loire
city: Ulm
country: Germany
facility: Universitaetsklinikum Ulm /ID# 258616
state: Baden-Wuerttemberg
city: Ludwigshafen am Rhein
country: Germany
facility: St. Marien- und St. Annastiftskrankenhaus /ID# 264691
state: Rheinland-Pfalz
city: Leipzig
country: Germany
facility: Eugastro /ID# 260229
state: Sachsen
city: Kiel
country: Germany
facility: Universitaetsklinikum Schleswig-Holstein Campus Kiel /ID# 258614
state: Schleswig-Holstein
city: Hamburg
country: Germany
facility: Universitaetsklinikum Hamburg-Eppendorf /ID# 258617
city: Munich
country: Germany
facility: Klinikum rechts der Isar /ID# 260228
city: Athens
country: Greece
facility: General Hospital of Chest Diseases of Athens SOTIRIA /ID# 257831
state: Attiki
city: Heraklion
country: Greece
facility: University General Hospital of Heraklion PA.G.N.I /ID# 257832
state: Kriti
city: Athens
country: Greece
facility: General Hospital of Athens Evaggelismos and Ophthalmiatrio of Athens Polyclinic /ID# 257829
city: Thessaloniki
country: Greece
facility: General Hospital of Thessaloniki Hippokrateio /ID# 260810
city: Szekszárd
country: Hungary
facility: Clinfan /ID# 258094
state: Tolna
city: Budapest
country: Hungary
facility: Clinexpert Kft /ID# 258449
city: Budapest
country: Hungary
facility: Synexus Hungary Clinical Research Centre - Budapest /ID# 258915
city: Budapest
country: Hungary
facility: Semmelweis Egyetem /ID# 258527
city: Szeged
country: Hungary
facility: Szegedi Tudományegyetem /ID# 258095
city: Elm Park
country: Ireland
facility: St Vincent's University Hospital /ID# 261560
state: Dublin
city: Dublin
country: Ireland
facility: Beaumont Hospital /ID# 261561
city: Be'er Sheva
country: Israel
facility: Soroka University Medical Center /ID# 258530
state: HaDarom
city: Zerifin
country: Israel
facility: Yitzhak Shamir Medical Center /ID# 258533
state: HaMerkaz
city: Ramat Gan
country: Israel
facility: The Chaim Sheba Medical Center /ID# 258532
state: Tel-Aviv
city: Tel Aviv
country: Israel
facility: Tel Aviv Sourasky Medical Center /ID# 258528
state: Tel-Aviv
city: Jerusalem
country: Israel
facility: Shaare Zedek Medical Center /ID# 258529
state: Yerushalayim
city: Petah Tikva
country: Israel
facility: Rabin Medical Center /ID# 258531
city: Monserrato
country: Italy
facility: Azienda Ospedaliero Universitaria di Cagliari - P.O. Duilio Casula /ID# 258455
state: Cagliari
city: Rome
country: Italy
facility: Azienda Ospedaliera San Camillo Forlanini /ID# 258453
state: Roma
city: Rome
country: Italy
facility: Fondazione Policlinico Universitario Agostino Gemelli IRCCS-Università Cattolica /ID# 258452
state: Roma
city: Negrar
country: Italy
facility: IRCCS Ospedale Sacro Cuore Don Calabria /ID# 258456
state: Verona
city: Gamagori-shi
country: Japan
facility: Gamagori City Hospital /ID# 260682
state: Aichi
city: Nagakute
country: Japan
facility: Aichi Medical University Hospital /ID# 258867
state: Aichi
city: Kashiwa-shi
country: Japan
facility: Tsujinaka Hospital Kashiwanoha /ID# 258548
state: Chiba
city: Urayasu-shi
country: Japan
facility: Juntendo University Urayasu Hospital /ID# 259582
state: Chiba
city: Kitakyushu
country: Japan
facility: Kitakyushu Municipal Medical Center /ID# 259600
state: Fukuoka
city: Fukushima-shi
country: Japan
facility: Fukushima Medical University Hospital /ID# 259591
state: Fukushima
city: Gifu-shi
country: Japan
facility: Gifu University Hospital /ID# 259572
state: Gifu
city: Ogaki-shi
country: Japan
facility: Ogaki Municipal Hospital /ID# 259905
state: Gifu
city: Fukuyama-shi
country: Japan
facility: NHO Fukuyama Medical Center /ID# 258861
state: Hiroshima
city: Kobe-shi
country: Japan
facility: Aoyama Clinic /ID# 259587
state: Hyogo
city: Nishinomiya-shi
country: Japan
facility: Hyogo Medical University Hospital /ID# 258827
state: Hyogo
city: Kagoshima-shi
country: Japan
facility: Sameshima Hospital /ID# 259589
state: Kagoshima
city: Kagoshima-shi
country: Japan
facility: Kagoshima IBD Gastroenterology Clinic /ID# 259603
state: Kagoshima
city: Fujidera-shi
country: Japan
facility: Sai Gastroenterology and Proctology Clinic /ID# 260832
state: Osaka
city: Osaka-shi
country: Japan
facility: Kinshukai Infusion Clinic /ID# 259588
state: Osaka
city: Saga-shi
country: Japan
facility: Saga University Hospital /ID# 259625
state: Saga
city: Saitama-shi
country: Japan
facility: Tokitokai Tokito clinic /ID# 259036
state: Saitama
city: Hamamatsu-shi
country: Japan
facility: Hamamatsu University Hospital /ID# 259580
state: Shizuoka
city: Sunto-gun
country: Japan
facility: NHO Shizuoka Medical Center /ID# 259033
state: Shizuoka
city: Bunkyo-ku
country: Japan
facility: Institute of Science Tokyo Hospital /ID# 259003
state: Tokyo
city: Hachioji-shi
country: Japan
facility: Tokai University Hachioji Hospital /ID# 258897
state: Tokyo
city: Mitaka-shi
country: Japan
facility: Kyorin University Hospital /ID# 259843
state: Tokyo
city: Shinjuku-ku
country: Japan
facility: Center hospital of the National Center for Global Health and Medicine /ID# 259598
state: Tokyo
city: Toyama-shi
country: Japan
facility: Toyama Prefectural Central Hospital /ID# 259499
state: Toyama
city: Busan
country: Korea, Republic of
facility: Inje University Haeundae Hospital /ID# 258822
state: Busan Gwang Yeogsi
city: Busan
country: Korea, Republic of
facility: Dong-A University Medical Center /ID# 258423
state: Busan Gwang Yeogsi
city: Daejeon
country: Korea, Republic of
facility: The Catholic University of Korea, Daejeon St. Mary's Hospital /ID# 258424
state: Daejeon Gwang Yeogsi
city: Seoul
country: Korea, Republic of
facility: Kangbuk Samsung Hospital /ID# 258416
state: Seoul Teugbyeolsi
city: Seoul
country: Korea, Republic of
facility: Samsung Medical Center /ID# 258420
state: Seoul Teugbyeolsi
city: Seoul
country: Korea, Republic of
facility: Yonsei University Health System Severance Hospital /ID# 258422
city: Daugavpils
country: Latvia
facility: SIA Polana-D /ID# 262932
city: Liepaja
country: Latvia
facility: Liepaja Regional Hospital /ID# 261484
city: Riga
country: Latvia
facility: Pauls Stradins Clinical University Hospital /ID# 261483
city: Kaunas
country: Lithuania
facility: Hospital of Lithuanian University of Health Sciences Kaunas Clinics /ID# 261486
city: Panevezys
country: Lithuania
facility: Panevezys Republican Hospital /ID# 261780
city: Vilnius
country: Lithuania
facility: Vilnius University Hospital Santaros Klinikos /ID# 261487
city: Hamilton
country: New Zealand
facility: Waikato Hospital /ID# 258607
state: Waikato
city: Lower Hutt
country: New Zealand
facility: Hutt Hospital /ID# 258608
state: Wellington
city: Otago
country: New Zealand
facility: Dunedin Hospital /ID# 258584
city: Nordbyhagen
country: Norway
facility: Akershus Universitetssykehus /ID# 261586
state: Akershus
city: Tromsø
country: Norway
facility: Universitetssykehuset I Nord-Norge /ID# 261649
state: Troms
city: Wrocław
country: Poland
facility: Centrum Medyczne Melita Medical /ID# 258379
state: Dolnoslaskie
city: Torun
country: Poland
facility: Gastromed Sp. z o.o /ID# 258310
state: Kujawsko-pomorskie
city: Ksawerow
country: Poland
facility: Centrum Opieki Zdrowotnej Orkan-Med Stec-Michalska Sp. j. /ID# 258842
state: Lodzkie
city: Lublin
country: Poland
facility: Medrise Sp. z o.o. /ID# 258561
state: Lubelskie
city: Chojnice
country: Poland
facility: Centrum Medyczne LukaMed Joanna Luka /ID# 258457
state: Pomorskie
city: Tychy
country: Poland
facility: H-T Centrum Medyczne Endoterapia /ID# 258540
state: Slaskie
city: Szczecin
country: Poland
facility: Twoja Przychodnia SCM /ID# 259280
state: Zachodniopomorskie
city: Bayamon
country: Puerto Rico
facility: Clinical Research Investigator Group, LLC /ID# 260647
city: San Juan
country: Puerto Rico
facility: Caribbean Medical Research Center /ID# 268395
city: San Juan
country: Puerto Rico
facility: School of Medicine University of Puerto Rico-Medical Science Campus /ID# 258508
city: Belgrade
country: Serbia
facility: Clinical Hosp Center Zvezdara /ID# 257766
state: Beograd
city: Belgrade
country: Serbia
facility: University Clinical Center Serbia /ID# 257764
state: Beograd
city: Belgrade
country: Serbia
facility: Clinical Hospital Center Dr Dragisa Misovic - Dedinje /ID# 257768
state: Beograd
city: Belgrade
country: Serbia
facility: Clin Hosp Ctr Bezanijska Kosa /ID# 257765
state: Beograd
city: Leskovac
country: Serbia
facility: General Hospital Leskovac /ID# 257767
state: Jablanicki Okrug
city: Novi Sad
country: Serbia
facility: University Clinical Center Vojvodina /ID# 257763
city: Celje
country: Slovenia
facility: General Hospital Celje /ID# 261482
city: Ljubljana
country: Slovenia
facility: Univ Medical Ctr Ljubljana /ID# 261474
city: Murska Sobota
country: Slovenia
facility: Splosna bolnisnica Murska Sobota /ID# 262486
city: Johannesburg
country: South Africa
facility: Clinresco Centers /ID# 258431
state: Gauteng
city: Pretoria
country: South Africa
facility: Johese Clinical Research Midstream /ID# 260195
state: Gauteng
city: CAPE TOWN Milnerton
country: South Africa
facility: Spoke Research Inc /ID# 258432
state: Western Cape
city: Cape Town
country: South Africa
facility: Private Practice Dr MN Rajabally /ID# 260671
state: Western Cape
city: Santiago de Compostela
country: Spain
facility: Complejo Hospitalario Universitario de Santiago (CHUS) /ID# 259114
state: A Coruna
city: Pamplona
country: Spain
facility: Hospital Universitario de Navarra /ID# 258173
state: Navarra
city: Madrid
country: Spain
facility: Hospital Universitario La Paz /ID# 258172
city: Sevilla
country: Spain
facility: Hospital Universitario Virgen Macarena /ID# 258175
city: Bern
country: Switzerland
facility: Inselspital, Universitaetsspital Bern /ID# 260106
city: Bern
country: Switzerland
facility: Intesto /ID# 260114
city: Taipei City
country: Taiwan
facility: National Taiwan University Hospital /ID# 258476
state: Taipei
city: Hsinchu City
country: Taiwan
facility: National Taiwan University Hospital - Hsinchu branch /ID# 259422
city: Taichung
country: Taiwan
facility: China Medical University Hospital /ID# 258478
city: Taoyuan City
country: Taiwan
facility: Linkou Chang Gung Memorial Hospital /ID# 258724
city: Cambridge
country: United Kingdom
facility: Addenbrooke's Hospital /ID# 258744
state: Cambridgeshire
city: Glasgow
country: United Kingdom
facility: Gartnavel General Hospital /ID# 258741
state: Glasgow City
city: London
country: United Kingdom
facility: Dup_Guys and St Thomas NHS Foundation Trust - Guy's Hospital /ID# 258730
state: Greater London
city: Oxford
country: United Kingdom
facility: Oxford University Hospitals NHS Foundation Trust /ID# 258745
state: Oxfordshire
city: London
country: United Kingdom
facility: Barts Health NHS Trust /ID# 258600
Study officials:
affiliation: AbbVie
name: ABBVIE INC.
role: STUDY_DIRECTOR
References: