louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT06511375: Comparative Effects of Sprint and Power Training in Cricket Fast Bowlers
Official title: Comparative Effects of Sprint and Power Training on Speed and Repeated Sprint Ability in Cricket Fast Bowlers
Study type: INTERVENTIONAL
Overall status: RECRUITING
Phase: NA
Conditions: Sports Physical Therapy
Lead sponsor: Riphah International University
Sponsor class: OTHER
First posted: 2024-07-19
Enrollment: 34
Sex: ALL
Minimum age (years): 18
Maximum age (years): 30
Standard ages: ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: Sprints can be a really effective way to improve participants cardiovascular fitness, strength and power, and running economy. Participants can gain bigger improvements and in less time with sprinting than with continuous easy running. Power training typically involves exercises which apply the maximum amount of force as fast as possible. Both these trainings are vital to increase the speed and repeated sprint ability in cricket fast bowlers.

Detailed description: Fast bowling requires a highly specialized and unique training approach as the whole body is used in the delivery of the ball to achieve maximum velocity. For this purpose, the fast bowlers must perform the sprint training which is high intensity interval training as it boosts the speed and power, helps to run faster, build muscles and increase the cardiovascular health. Along with sprint training fast bowlers undergo power training which also helps to run faster, improve strength and speed and maintain fitness.

It will be a Randomized clinical trial with sample size of 34 calculated by G-power with 10- m sprint test, using non probability convenient sampling technique. The study will include physically fit and healthy fast bowlers of age 18-30 years. Participants will be divided into 2 equal experimental groups. One group will perform sprint training which include 10 meter run or repeated sprint ability and other will perform power training including squat jump or countermovement jump consisting of 12 sessions for 4 weeks (3 sessions each week). Data will be assessed by using SPSS version 25

Eligibility criteria: Inclusion Criteria:

1. Age: 18- 30 years
2. Fast bowlers (male and female)
3. Physically fit and healthy athletes
4. Players must have fast bowling experience of at least 2 years. -

Exclusion Criteria:

1. Fast bowlers with musculoskeletal conditions ( back pain, foot and ankle injuries, fracture of lower limb and bone deformity, patellar tendinopathy, ligamentous and meniscal injury)
2. Vestibular and visual disorders
3. cardiac and respiratory issues -

Primary outcomes:
measure: Speed
timeFrame: 10 months
measure: Repeated Sprint Ability
timeFrame: 10 months
Secondary outcomes:
Other outcomes:
Locations:
city: Zafarwal
country: Pakistan
facility: Zafarwal playzone
state: Punjab
Study officials:
affiliation: Riphah International University
name: Amna Shahid, T-DPT
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT05611775: Adult Spinal Deformity Surgery Real-World Functional Activity
Official title: Real-World Functional Activity in Adult Spinal Deformity Surgery
Study type: INTERVENTIONAL
Overall status: RECRUITING
Phase: NA
Conditions: Degenerative Thoracolumbar Deformity
Lead sponsor: Mayo Clinic
Sponsor class: OTHER
First posted: 2022-11-10
Enrollment: 50
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: SUPPORTIVE_CARE

Brief summary: The purpose of this study is to measure functional activity and stability in spinal deformity patients utilizing motion analysis testing and accelerometers.


Eligibility criteria: Inclusion Criteria:

* Diagnosis of degenerative thoracolumbar deformity
* Deformity correction surgery scheduled with either Dr. Elder or Dr. Fogelson, minimum 4-level fusion with fixation to the pelvis.

Exclusion Criteria:

° Unable to return to Mayo Clinic for follow-up evaluation

Primary outcomes:
measure: Motion Analysis Lab - Change in function
timeFrame: Baseline, 6-12 weeks post-surgery, 1 year
measure: Motion Analysis Lab - Change in gait
timeFrame: Baseline, 6-12 weeks post-surgery, 1 year
measure: Motion Analysis Lab - Change in trunk stability
timeFrame: Baseline, 6-12 weeks post-surgery, 1 year
Secondary outcomes:
Other outcomes:
Locations:
city: Rochester
country: United States
facility: Mayo Clinic Minnesota
state: Minnesota
Study officials:
affiliation: Mayo Clinic
name: Benjamin Elder, MD, PhD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT03432975: Evaluation of Multiple Subgingival Irrigations.
Official title: Evaluation of Multiple Subgingival Irrigations With 10% Povidone Iodine After Scaling and Root Planing : a Randomized Clinical Trial
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Periodontitis, Adult
Lead sponsor: Cliniques universitaires Saint-Luc- Université Catholique de Louvain
Sponsor class: OTHER
First posted: 2018-02-14
Enrollment: 20
Sex: ALL
Minimum age (years): 30
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Intervention model description: 20 patients (=40 half-mouth); 20 half-mouth per group
Primary purpose: TREATMENT

Brief summary: The study will be conducted at the Department of Periodontology, Cliniques universitaires Saint Luc. Patients diagnosed with Generalized Chronic Periodontitis (GChP) based on the current classification of the American Academy of Periodontology will be included. Detailed medical, periodontal and dental history will be obtained. Those who will fulfill the inclusion/exclusion criteria will be invited to participate in the study.

Detailed description: The study will be conducted at the Department of Periodontology, Cliniques universitaires Saint Luc. The patients will be informed in detail of the nature and course of study, and will sign informed consent prior to engagement in the study. Patients diagnosed with GChP based on the current classification of the American Academy of Periodontology will be included. Detailed medical, periodontal and dental history will be obtained. Those who will fulfill the inclusion/exclusion criteria will be invited to participate in the study.

Eligibility criteria: Inclusion Criteria:

* ≥ 30 years of age
* At least 15 teeth (excluding third molars and teeth with advanced decay indicated for extraction)
* Any history of periodontal treatment in the previous 6 months
* No removable prosthesis
* A minimum of 6 teeth with at least one site each with periodontal probing depth (PPD) and clinical attachment level (CAL) ≥5 mm
* At least 30% of the sites with PPD and CAL ≥4 mm and bleeding on probing (BOP)

Exclusion Criteria:

* Any sensitivity or allergy to any of the products that will be used in the study
* Thyroid dysfunction
* Systemic disease (ASA II or more)
* Need for antibiotic pre-medication for routine dental therapy
* Antibiotic therapy in the previous 3 months
* Pregnancy and breastfeeding
* Current smokers (more than 5 cigarettes a day)

Primary outcomes:
measure: Percentage of subjects reaching ≤ 4 mm in periodontal sites with PPD ≥ 5 mm
timeFrame: up to 6 months
Secondary outcomes:
Other outcomes:
Locations:
city: Brussels
country: Belgium
facility: Cliniques Universitaires Saint-Luc
Study officials:
References:
Clinical trial NCT06209775: Impact of Perioperative Body Composition Abnormalities on Patient Outcomes After Liver Transplantation
Official title: Impact of Perioperative Body Composition Abnormalities on Patient Outcomes After Liver Transplantation
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Liver Transplantation
Body Composition
Lead sponsor: Zhejiang University
Sponsor class: OTHER
Collaborators: name: First Affiliated Hospital of Zhejiang University
name: Shulan (Hangzhou) Hospital
name: The Affiliated Hospital of Qingdao University
First posted: 2024-01-17
Enrollment: 996
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: RETROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Liver transplant patients from 3 transplant centers in China

Brief summary: Accumulating evidence suggests the prognostic significance of body composition in chronic diseases and neoplastic diseases. CT imaging-based body composition abnormalities are significantly associated with post-LT adverse outcomes including decreased quality of life (QOL), impaired graft regeneration and mortality. However, the perioperative changes in body composition and their potential clinical implications remain unexplored. The objective of this study is to systematically explore and clarify the correlation between body composition and the prognosis of liver transplant patients through dynamic peri-transplant mornitoring.


Eligibility criteria: Inclusion Criteria:

* Adult patients undergoing deceased donor liver transplantation (DDLT) for the first time.

Exclusion Criteria:

* Pediatric transplants
* Re-transplants
* Multi-organ transplants
* Liver cancer patients with macrovascular invasion or distant metastasis
* Patients who died within 30 days after transplantation

Primary outcomes:
measure: Postoperative mortality
timeFrame: 2015.1.1-2022.12.31
measure: Postoperative recurrence of liver cancer
timeFrame: 2015.1.1-2022.12.31
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
References:
Clinical trial NCT01585675: Specimen Banking From Patients With Lung Cancer
Official title: Specimen Banking From Patients With Lung Cancer
Study type: OBSERVATIONAL
Overall status: RECRUITING
Conditions: Lung Neoplasms
Keywords: Lung Cancer
Lead sponsor: University of Colorado, Denver
Sponsor class: OTHER
Collaborators: name: National Cancer Institute (NCI)
First posted: 2012-04-26
Enrollment: 2000
Sex: ALL
Minimum age (years): 18
Maximum age (years): 85
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: OTHER
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: Subjects who are undergoing further testing for the diagnosis or treatment of lung cancer.

Brief summary: The primary objective of the protocol is to develop a comprehensive specimen banking program from patients with lung cancer for future translation research, which will enable the investigators to detect lung cancer earlier, develop better therapies and explore screening and prevention strategies.

Detailed description: The aims of the study are as follows: 1) to continue to unravel the complex biology of lung cancer 2) to identify early detection and prognostic markers to guide therapeutic decision 3) to define markers of response and/or resistance to drug therapy, and 4) to identify new therapeutic and prevention targets.

Eligibility criteria: Inclusion Criteria:

1. Subjects who are undergoing further testing for the diagnosis or treatment of lung cancer.
2. Oral and written informed consent

Exclusion Criteria:

1. Any individual who does not give oral and written consent for participation

Primary outcomes:
measure: Development of a comprehensive specimen banking program from patients with lung cancer for future translational research.
timeFrame: 6 years
Secondary outcomes:
Other outcomes:
Locations:
city: Aurora
country: United States
facility: University of Colorado Cancer Center
state: Colorado
Study officials:
affiliation: University of Colorado, Denver
name: Adriaan VanBokhoven, PhD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT06255275: Impact of Perceptive, Executive and Emotional Factors on Decision-making of Pedestrian Face to Autonomous Vehicles.
Official title: Impact of Perceptive, Executive and Emotional Factors on Decision-making in the Context of Pedestrian Crossing in an Industrial Environment Involving Traffic of Autonomous Vehicles (forklifts)
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Decision-making
Lead sponsor: Centre Hospitalier Universitaire de Besancon
Sponsor class: OTHER
Collaborators: name: University of Franche-Comté
First posted: 2024-02-13
Enrollment: 100
Sex: ALL
Minimum age (years): 18
Maximum age (years): 45
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: BASIC_SCIENCE

Brief summary: The VASIS project aims to assess the impact of perceptual, executive and emotional factors on decision-making in the context of pedestrian crossing in an industrial environment involving autonomous vehicle traffic (forklift).


Eligibility criteria: Inclusion Criteria:

* subjects aged 18 to 45
* no objection following submission of a non-objection form indicating that the subject has understood the purpose and procedures of the study and agrees to participate in the study and to comply with the requirements and restrictions inherent in the study

Exclusion Criteria:

* legal incapacity or limited legal capacity
* subject unlikely to cooperate with the study and/or poor cooperation anticipated by the investigator
* pregnant or breast-feeding women
* color-blind subject
* history of cardiovascular disease
* current psychiatric or neurological disorders (including self-reported diagnoses of epilepsy)
* known vestibular disorders (prone to frequent dizziness or vertigo)
* headaches or migraines
* deafness
* subjects under the influence of psychotropic substances (alcohol, drugs)
* motor disorders likely to prevent crossing

Primary outcomes:
measure: Evaluation of the impact of the attention of participants on decision-making in the context of pedestrian crossing (virtual reality), particularly on the time required to cross safely, in an industrial environment involving autonomous vehicle traffic.
timeFrame: Day 0
Secondary outcomes:
Other outcomes:
Locations:
city: Besançon
country: France
facility: Besançon University Hospital
Study officials:
References:
Clinical trial NCT01209975: Retinal Vascular Reactivity in Subjects With Newly Diagnosed Glaucoma Before and After Selective Laser Trabeculoplasty
Official title: Retinal Vascular Reactivity in Response to Isoxic Hypercapnia in Subjects With Newly Diagnosed Glaucoma
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Glaucoma
Keywords: blood flow
glaucoma
SLT
Lead sponsor: University of Toronto
Sponsor class: OTHER
Collaborators: name: University of Western Ontario, Canada
First posted: 2010-09-28
Enrollment: 12
Sex: ALL
Minimum age (years): 40
Maximum age (years): 75
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: CASE_ONLY
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: patient with untreated primary open angle glaucoma

Brief summary: The purpose of this study is to assess retinal blood flow and vascular reactivity in patients with newly diagnosed primary open angle glaucoma pre- and post-primary Selective Laser Trabeculoplasty(SLT). Canon Laser Blood Flowmeter will be used for the assessment of retinal blood flow.

Detailed description: We previously found that vascular reactivity improved after short term treatment with dorzolamide drops. It is not clear whether this improvement was a direct effect of the medication or secondary effect of the decrease in IOP. We would like to see the change of vascular reactivity before and after SLT, which will decrease the intraocular pressure without pharmacologic effect.

Eligibility criteria: Inclusion Criteria:

1. Age 40-75 years (Male or Female)
2. Best corrected visual acuity of at least 20/40
3. No previous treatment for glaucoma
4. Ametropia less than ±6.0 DS and ±2.5 DC)
5. Non-smoker
6. No cardiovascular/respiratory disorders

Exclusion Criteria:

1. Past history of diabetes and cerebrovascular accident
2. Vascular occlusive disease affecting the ocular circulation such as: diabetic retinopathy, retinal vein occlusion and retinal artery occlusion
3. Previous intraocular surgery
4. Ocular media opacities limiting the use of the imaging tests

Primary outcomes:
measure: blood flow
timeFrame: before and two-week after SLT
Secondary outcomes:
measure: Intraocuclar pressure
timeFrame: before and two-week after SLT
Other outcomes:
Locations:
city: Toronto
country: Canada
facility: Toronto Western Hospital
state: Ontario
Study officials:
affiliation: University of Toronto
name: Chris Hudson, PhD
role: PRINCIPAL_INVESTIGATOR
References:
citation: Venkataraman ST, Hudson C, Rachmiel R, Buys YM, Markowitz SN, Fisher JA, Trope GE, Flanagan JG. Retinal arteriolar vascular reactivity in untreated and progressive primary open-angle glaucoma. Invest Ophthalmol Vis Sci. 2010 Apr;51(4):2043-50. doi: 10.1167/iovs.09-3630. Epub 2009 Nov 11.
Clinical trial NCT00588575: Ramanspectroscopy in Barrett's Esophagus
Official title: In-Vivo Raman Spectroscopy of Barrett's Esophagus
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Barrett's Esophagus
Keywords: Barrett's Esophagus
Lead sponsor: Mayo Clinic
Sponsor class: OTHER
Collaborators: name: National Institutes of Health (NIH)
First posted: 2008-01-08
Enrollment: 119
Sex: ALL
Minimum age (years): 18
Maximum age (years): 85
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Barrett's esophagus surveillance

Brief summary: This study is being done to see if a new device, called near-infrared Raman spectroscopy, can provide similar information as that obtained from taking biopsies of the lining of your Barrett's esophagus

Detailed description: In the search for means to enhance the surveillance of BE, optical spectroscopy is emerging as a candidate with high potential. Optical spectroscopic techniques measure specific light-tissue interactions, such as fluorescence, elastic scattering, and Raman (inelastic) scattering, which provide objective and quantitative diagnostic information about the molecular and/or structural status of tissue. Moreover, optical spectroscopy has the capacity to identify tissue pathology in situ in a rapid and non-destructive fashion. Among the optical spectroscopic techniques, near-infrared Raman spectroscopy (NIRS) is particularly promising because of the wealth of molecular-specific information contained in its spectra

Eligibility criteria: Inclusion Criteria:

* Closed to further enrollment

Primary outcomes:
Secondary outcomes:
Other outcomes:
Locations:
city: Rochester
country: United States
facility: Mayo Clinic
state: Minnesota
Study officials:
affiliation: Mayo Clinic
name: Louis M Wongkeesong, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT01635075: Acute Effects of Exercise in Smokers With Schizophrenia
Official title: Acute Effects of Exercise in Smokers With Schizophrenia
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE2
Conditions: Tobacco Dependence
Cigarette Craving
Smoking Behavior
Keywords: psychiatric
comorbidity
craving
tobacco
Lead sponsor: Brown University
Sponsor class: OTHER
First posted: 2012-07-06
Enrollment: 30
Sex: ALL
Minimum age (years): 18
Maximum age (years): 60
Standard ages: ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: CROSSOVER
Primary purpose: BASIC_SCIENCE

Brief summary: People with schizophrenia have two- to three-times the mortality risk of the general population. This is primarily due to their unusually high rates of cigarette smoking, as well as other cardiovascular risk factors such as physical inactivity, obesity, high blood cholesterol and diabetes. Effective smoking treatments are needed to reduce morbidity and mortality in this population. Over a dozen experimental studies indicate that walking and other forms of exercise acutely reduce cigarette craving, nicotine withdrawal symptoms and smoking behavior in non-psychiatric smokers. However, the effects of acute exercise on smoking measures have not been studied in smokers with schizophrenia. This study will use a within-subjects, repeated-measures design, in which participants will undergo 4 laboratory sessions (order counterbalanced across participants): (1) smoking cues followed by exercise, (2) smoking cues followed by passive activity, (3) neutral cues followed by exercise, (4) neutral cues followed by passive activity. Outcome measures include cigarette craving, nicotine withdrawal symptoms, mood and smoking behavior. If the results of this study indicate that walking acutely reduces craving and smoking in smokers with schizophrenia, the next step in this research would be to test the effectiveness of a smoking cessation intervention that incorporates exercise bouts as a behavioral strategy for improving smoking cessation rates in this population.


Eligibility criteria: Inclusion Criteria:

* diagnosis of schizophrenia
* smoke at least 20 cigarettes per day
* less than 60 min moderate-intensity exercise per week

Exclusion Criteria:

* medication changes in past 4 weeks
* unable to give informed consent to participate
* alcohol/drug screen
* pregnant or nursing
* receiving or seeking immediate smoking treatment

Primary outcomes:
measure: Cigarette craving
timeFrame: within 10 minutes before and after exercise (or control activity)
Secondary outcomes:
measure: Mood
timeFrame: within 10 minutes before and after exercise (or control activity)
measure: Smoking habit withdrawal
timeFrame: within 10 minutes before and after exercise (or control activity)
measure: Smoking choice
timeFrame: initiated 10 minutes after exercise (or control activity)
Other outcomes:
Locations:
city: Providence
country: United States
facility: Brown University
state: Rhode Island
Study officials:
affiliation: Brown University
name: Jennifer Tidey, Ph.D.
role: PRINCIPAL_INVESTIGATOR
References: