Clinical trial NCT04849117: Effect of Bilateral Transversus Thoracis Muscle Plane Block in Patients Undergoing Coronary Artery Bypass Graft Surgery.
Official title: Effect of Bilateral Transversus Thoracis Muscle Plane Block on Postoperative Morphine Consumption in Patients Undergoing Elective On-pump Coronary Artery Bypass Graft Surgery: a Retrospective Study.
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Coronary Artery Disease
Pain Syndrome
Keywords: Cardiac Surgery
Coronary Artery Bypass Graft Surgery
Regional Anesthesia
Transversus Thoracis Muscle Plane Block
Enhanced Recovery After Surgery
Pain, evaluated by visual analog scale score.
Lead sponsor: University Hospital, Montpellier
Sponsor class: OTHER
First posted: 2021-04-19
Enrollment: 100
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: RETROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: "TTMP Block" group : fifty consecutive patients who underwent elective on-pump coronary artery bypass graft ± valve surgery after October 2019, with a postoperative analgesic protocol including a bilateral TTMP block, associate with systemic analgesia.

"Systemic Analgesia" group : age, gender and type of surgery-matched patients who underwent elective on-pump coronary artery bypass graft ± valve surgery before September 2019, with a postoperative analgesic protocol based on systemic analgesia only.

Brief summary: Coronary artery bypass graft surgery is the standard surgical treatment for coronary disease. However, there is no consensus on analgesic management in patients undergoing CABG.

The aim of the study is to evualuate efficacy of bilateral transversus thoracis muscle plane (TTMP) block combined with systemic analgesia, compared to systemic analgesia only, in patients undergoing elective on-pump CABG surgery.

Our main hypothesis is that a bilateral TTMP block performed after CABG surgery could reduce morphine consumption during the first 48 hours.

The investigators conducted an age, gender and type of surgery-matched retrospective cohort study in the Montpellier University Hospital (France).


Eligibility criteria: Inclusion criteria:

* To be over 18
* To be scheduled for CABG surgery in the center of the study during the study period.

Exclusion criteria:

* Chronic pain or opioid use before surgery
* Recent thoracic regional analgesia (\< 1 month)
* Preoperative dementia or other neurologic or psychiatric disease incompatible with VAS pain scoring.
* Other technique of regional anesthesia (e.g. thoracic epidural)
* Opposition to data collection

Secondary exlusion criteria:

* Postoperative prolonged sedation in ICU (\> 12 hours)
* Postoperative surgical complication requiring surgical revision during the first two days.
* Opposition to data collection expressed secondarily

Primary outcomes:
measure: cumulative morphine consumption
timeFrame: postoperative day 2
Secondary outcomes:
measure: Postoperative pain assessed
timeFrame: postoperative day 0, 1 and 2
measure: Postoperative nausea and vomiting
timeFrame: hospital day 7
measure: Occurrence of prurit
timeFrame: postoperative day 7
measure: rate of Delirium
timeFrame: postoperative day 7
measure: rate of Constipation
timeFrame: postoperative day 7
measure: rate of Urinary retention
timeFrame: until postoperative day 7
measure: rate of Hypotension
timeFrame: until postoperative day 7
measure: Pleural drain duration
timeFrame: day 20
measure: Urinary catheter duration
timeFrame: day 20
measure: Duration of hospitalization in ICU
timeFrame: day 20
measure: In-hospital length of stay
timeFrame: day 20
measure: Occurrence of atrial fibrillation
timeFrame: until postoperative day 7
measure: rate of Pneumonia
timeFrame: until postoperative day 7
measure: acute kidney injury
timeFrame: until postoperative day 7
Other outcomes:
Locations:
city: Montpellier
country: France
facility: Uh Montpellier
Study officials:
affiliation: UH MONTPELLIER
name: Pierre Sentenac, MD, PhD
role: PRINCIPAL_INVESTIGATOR
References: