louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT03182075: Computerized Training for Individuals Diagnosed With Obsessive-Compulsive and Related Disorders
Official title: Emotional Reactivity Training for Obsessive-Compulsive and Related Disorders
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Obsessive Compulsive Disorder
Keywords: Obsessive-Compulsive Disorder
OCD
Obsessive Personality Disorder
Compulsive Behavior
Personality Disorders
Mental Disorders
Anxiety Disorders
Impulsive Behavior
Cognition
Emotion
Emotional Regulation
Lead sponsor: Stanford University
Sponsor class: OTHER
First posted: 2017-06-09
Enrollment: 5
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: SUPPORTIVE_CARE

Brief summary: Obsessive-Compulsive Disorder (OCD) is a chronic and disabling disorder that costs the economy over $2 billion annually and represents a significant public health problem. This study aims to build on our understanding of aberrant emotional processing in OCD. The proposed project tests whether a computerized training aimed to alter emotional processes, can relieve repetitive thoughts and behaviors.


Eligibility criteria: Inclusion Criteria:

* age 18 years old and older
* primary diagnosis of OCD
* sufficient severity of OCD symptoms
* Stable on psychotropic or other medication
* capacity to provide informed consent

Exclusion criteria:

* psychiatric or medical conditions that make participation unsafe
* concurrent use of any medications that might increase the risk of participation
* concurrent Cognitive-Behavioral therapy for OCD

Primary outcomes:
measure: Yale-Brown Obsessive Compulsive Scale (for participants diagnosed with OCD)
timeFrame: up to 2 months
measure: Savings Inventory Revised Scale (for participants diagnosed with hoarding disorder)
timeFrame: up to 2 months
Secondary outcomes:
Other outcomes:
Locations:
city: Stanford
country: United States
facility: Stanford University
state: California
Study officials:
References:
Clinical trial NCT00861575: Cardiogenomics Registry
Official title: CAD Genotype and Phenotype Cardiac Catheterization Laboratory Registry
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Cardiovascular Disease
Keywords: Cardiovascular
Lead sponsor: Piedmont Healthcare
Sponsor class: OTHER
First posted: 2009-03-13
Enrollment: 2601
Sex: ALL
Minimum age (years): 18
Maximum age (years): 99
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Subjects undergoing a clinical required cardiovascular procedure

Brief summary: This is a continuous blood banking study that will archive plasma and blood permitting DNA and plasma analysis at a future date. Subjects are recruited at the time of a clinically required procedure and blood samples are collected and banked and used for future research. The main purpose of this study is to investigate the interaction of multiple phenotypes and genotypes and their impact on cardiovascular disease events and measures of atherosclerosis progression.


Eligibility criteria: Inclusion Criteria:

* \> 17 years of age
* Undergoing a clinical required cardiovascular procedure
* Agree to donation of blood sample
* Provide written informed consent and Authorization for Use/Disclosure of PHI

Exclusion Criteria:

* \< 18 years of age
* Refusal to donate a blood sample
* Refusal to provide written informed consent and Authorization for Use/Disclosure of PHI

Primary outcomes:
measure: To assess the relationship of multiple phenotypes and genotypes with cardiovascular disease
timeFrame: Yearly
Secondary outcomes:
measure: To assess the impact of phenotypes and genotypes of specific patient subgroups (gender, ethnic, family history) on cardiovascular disease
timeFrame: Yearly
Other outcomes:
Locations:
city: Atlanta
country: United States
facility: Piedmont Hospital
state: Georgia
Study officials:
affiliation: Piedmont Healthcare
name: Sarah Rinehart, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT05538975: Effect of Self-directed and Supervised Pulmonary Rehabilitation Approach on Cough and Sputum.
Official title: Effect of Self-directed and Supervised Pulmonary Rehabilitation Approach on Cough and Sputum Expectoration in Chronic Obstructive Pulmonary Disease
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: COPD
Pulmonary Disease
Lead sponsor: Afridi Medical Complex
Sponsor class: OTHER
First posted: 2022-09-14
Enrollment: 40
Sex: ALL
Minimum age (years): 40
Maximum age (years): 60
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: Chronic obstructive pulmonary disease (COPD)is a multifactorial, progressive chronic lung disease that causes airflow restriction. Study was conducted To Compare the effects of supervised and self-directed pulmonary rehabilitation on cough and sputum expectoration in patients of chronic obstructive pulmonary disease.

Detailed description: To Compare the effects of supervised and self-directed pulmonary rehabilitation on cough and sputum expectoration in patients of chronic obstructive pulmonary disease. It was a randomised control trial and participants were COPD Patients.

Eligibility criteria: Inclusion Criteria:

* Age: 40 to 60
* Gender: Both Males \& Females.
* Diagnoses with an exacerbation of COPD.
* Informed consent obtained.

Exclusion Criteria:

* Inability to provide informed consent or complete a self-administered questionnaire.
* Patients with trauma.
* Females who were pregnant and breastfeeding.

Primary outcomes:
measure: Six minute walk test
timeFrame: 6 months
measure: Cough & sputum assessment questionnaire.
timeFrame: 6 months
Secondary outcomes:
measure: leicester cough questionnaire
timeFrame: 6 months
Other outcomes:
Locations:
city: Peshawar
country: Pakistan
facility: Pulmonary Rehabilitation
state: KP
Study officials:
affiliation: Afridi Medical Complex
name: Syed Alamdar Hussain, Phd
role: STUDY_DIRECTOR
References:
Clinical trial NCT02603575: Effects and Safety of Caspofungin and Corticosteroids in Pneumocystis Pneumonia in Non-HIV Patients
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Pneumocystis Pneumonia
Keywords: Caspofungin
corticosteroids
Pneumocystis Pneumonia
Immunocompromised
Non-HIV
respiratory failure
Lead sponsor: Beijing Chao Yang Hospital
Sponsor class: OTHER
First posted: 2015-11-13
Enrollment: 60
Sex: ALL
Minimum age (years): 16
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: CROSSOVER
Primary purpose: TREATMENT

Brief summary: Pneumocystis Pneumonia is increasing in Immunocompromised Non-HIV Infected Patients. The effects and safety of caspofungin and corticosteroids is not certain in this population. All Immunocompromised Non-HIV patients with respiratory failure were randomized into caspofungin and non-caspofungin group and corticosteroids and non-steroids group. The major outcome is 28 day mortality, the second outcome are time of respiratory rate decreases to less than 25 breath per minute, body temperature lower than 37.3℃.


Eligibility criteria: Inclusion Criteria:

* Immunocompromised Non-HIV Infected Patients
* Partial arterial O2 pressure(PaO2)/FiO2≤300mmHg
* Diagnosed as Pneumocystis Pneumonia

Exclusion Criteria:

* younger than 16 years old
* severe organ failure
* allergic to sulfanilamide, caspofungin or corticosteroid

Primary outcomes:
measure: mortality
timeFrame: 28 days
Secondary outcomes:
measure: Time for release of fever
timeFrame: 2 days
measure: Time for release of respiratory distress
timeFrame: 2 days
Other outcomes:
Locations:
city: Beijing
country: China
facility: Beijing Chao Yang Hospital
Study officials:
References:
Clinical trial NCT00065975: Physical CAM Therapies for Chronic Low Back Pain
Official title: Physical CAM Therapies for Chronic Low Back Pain
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE2
Conditions: Chronic Low Back Pain
Keywords: chronic low back pain
acupuncture
chiropractic
massage therapy
CAM therapies
Lead sponsor: National Center for Complementary and Integrative Health (NCCIH)
Sponsor class: NIH
First posted: 2003-08-05
Enrollment: 120
Sex: ALL
Minimum age (years): 20
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: This is a pilot randomized trial intended to evaluate the effectiveness of acupuncture, chiropractic and massage for chronic back pain in older and younger adults.


Eligibility criteria: * Low back pain duration of at least 3 months;
* Low back pain occurring in the past week;
* No numbness or tingling in the lower extremities;
* No pain that radiates to below the knee;
* No use of massage, chiropractic or acupuncture for any reason in the past year;
* Able to attend scheduled appointments;
* Able to hear, read, and understand English;
* No low back pain surgery in the past 3 years;
* No unexplained weight loss;
* No previous vertebral or spinal fractures;
* No previous non-traumatic bone fractures;
* No other spinal pathology, including scoliosis, spinal stenosis, osteoporosis, or ankylosing spondylitis;
* No cancer (except simple skin cancers) in the past 5 years;
* No pacemakers;
* No bleeding problems or anticoagulant use;
* No major organ transplants;
* No oral corticosteroid use for more than 4 consecutive weeks during the past year;
* Cannot be pregnant;
* Must be able to get down to and up from the floor by yourself;
* Able to walk 2 flat city blocks unassisted;
* Willing to participate in periodic telephone interviews.

Primary outcomes:
Secondary outcomes:
Other outcomes:
Locations:
city: Boston
country: United States
facility: Harvard medical school
state: Massachusetts
city: Boston
country: United States
facility: Harvard Vanguard Medical Associates
state: Massachusetts
Study officials:
affiliation: Harvard Medical School (HMS and HSDM)
name: David Eisenberg, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT00592475: A Study to Assess the Safety and Effects of Intravenous (IV) Conivaptan on the Hepatic Hemodynamic Response in Cirrhotic Patients
Official title: A Phase 2, Randomized, Double Blind, Placebo Controlled, Dose Escalation Study to Assess the Safety and Effects of Intravenous Conivaptan on the Hepatic Hemodynamic Response in Stable Euvolemic or Hypervolemic Cirrhotic Patients
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE2
Conditions: Liver Cirrhosis
Keywords: conivaptan
Liver Cirrhosis
Hypertension, Portal
Lead sponsor: Cumberland Pharmaceuticals
Sponsor class: INDUSTRY
First posted: 2008-01-14
Enrollment: 20
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: To evaluate the safety of IV conivaptan in stable euvolemic or hypervolemic cirrhotic patients, and to characterize the effects of IV conivaptan on the hepatic hemodynamic response in patients with cirrhosis.


Eligibility criteria: Inclusion Criteria:

* Institutional Review Board (IRB)/Independent Ethics Committee (IEC)-approved written Informed Consent and appropriate privacy language as per national regulations must be obtained from the subject or legally authorized representative prior to any study-related procedures (including withdrawal of prohibited medication, if applicable)
* Subject is euvolemic or hypervolemic (edematous) secondary to cirrhosis
* Subject has clinical evidence of portal hypertension by the presence of esophageal varices, ascites or both

Exclusion Criteria:

* Clinical evidence of volume depletion or dehydration
* Subject has a history of bleeding from esophageal varices within three months before the start of the study

Primary outcomes:
measure: Change From Baseline in Hepatic Venous Pressure Gradient (HVPG) at 0.5, 1, and 1.5 Hours Post Dose
timeFrame: Baseline and 0.5, 1, and 1.5 hours post dose
measure: Change From Baseline in Hepatic Blood Flow (HBF) at 0.5, 1, and 1.5 Hours Post Dose
timeFrame: Baseline and 0.5, 1, and 1.5 hours post dose
measure: Change From Baseline in Hepatic Mean Arterial Pressure (MAP) at 0.5, 1, and 1.5 Hours Post Dose
timeFrame: Baseline and 0.5, 1, and 1.5 hours post dose
measure: Change From Baseline in Blood Pressure at 0.5, 1, 1.5, 2.5, 3.5, 4.5, 5.5, 6.5, 9, 12, and 24 Hours, and Day 8 Post Dose
timeFrame: Baseline and 0.5, 1, 1.5, 2.5, 3.5, 4.5, 5.5, 6.5, 9, 12, and 24 hours, and Day 8 post dose
measure: Change From Baseline in Heart Rate at 0.5, 1, 1.5, 2.5, 3.5, 4.5, 5.5, 6.5, 9, 12, and 24 Hours, and Day 8 Post Dose
timeFrame: Baseline and 0.5, 1, 1.5, 2.5, 3.5, 4.5, 5.5, 6.5, 9, 12, and 24 hours, and Day 8 post dose
Secondary outcomes:
measure: Change From Baseline in Serum Sodium Levels at 0.5, 1, 2.5, 4, 6.5, 9, 12, and 24 Hours and on Day 8 Post Dose
timeFrame: Baseline and 0.5, 1, 2.5, 4, 6.5, 9, 12, and 24 hours and on Day 8 post dose
Other outcomes:
Locations:
city: Barcelona
country: Spain
Study officials:
affiliation: Cumberland Pharmaceuticals, Inc.
name: Art Wheeler, MD
role: STUDY_DIRECTOR
References:
Clinical trial NCT01021475: Does Visceral Manipulation Works in Treating Functional Dyspepsia?
Official title: Does Visceral Manipulation Works in Treating Functional Dyspepsia? A Randomized Study
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: PHASE1
Conditions: Functional Dyspepsia
Keywords: Functional Dyspepsia, Visceral Manipulation
Lead sponsor: International College of Osteopathic Medicine
Sponsor class: OTHER
First posted: 2009-11-30
Enrollment: 50
Sex: ALL
Minimum age (years): 18
Maximum age (years): 65
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The goal of this study is to determine if Visceral Manipulation (VM) is effective in treating Functional Dyspepsia in addition to drug therapy.

Null hypothesis is that VM does not influence FD symptoms.

Detailed description: 50 patients with Functional Dyspepsia (FD) diagnosed by General Practitioners are randomized in two therapy group: 1) drug only group and 2) drug + Visceral Manipulation group. Group 1 receive drug therapy for 4 weeks, Group 2 receive drug therapy for 4 weeks and 4 Visceral Manipulation visits with weekly frequency (visit 1 at day 1 of drug therapy). FD symptoms are recorded with VAS at baseline and after 1 and 4 weeks of therapy, and after 8 weeks (4 weeks after the finish of all therapies).

Eligibility criteria: Inclusion Criteria:

* Clinical diagnosis of Functional Dyspepsia

Exclusion Criteria:

* Diabetes Mellitus
* Mental disturbance
* Thyroid gland dysfunction
* Intestinal, liver and biliary tract disease
* Concurrent medications that could interact with GI function
* Positive Helicobacter Pylori status

Primary outcomes:
measure: FD symptoms: Bothersome postprandial fullness / Early satiation / Epigastric pain / Epigastric burning
timeFrame: baseline, 1, 4 and 8 weeks after therapy start
Secondary outcomes:
Other outcomes:
Locations:
city: Cavenago Di Brianza
country: Italy
facility: Ambulatori Comunali di Cavenago Brianza
state: Milano
Study officials:
affiliation: International College of Osteopathic Medicine
name: Rossi Massimo, DO B.Sc (student)
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT00426075: Full-Leg vs Below-Knee Elastic Stockings for Prevention of the Post-Thrombotic Syndrome
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE3
Conditions: Deep Vein Thrombosis
Keywords: Deep vein thrombosis of the lower extremities
Lead sponsor: University of Padova
Sponsor class: OTHER
First posted: 2007-01-24
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: PREVENTION

Brief summary: Prospective controlled randomized clinical trial. Consecutive patients with acute proximal deep vein thrombosis of the lower extremities, with or without contemporary manifestations of pulmonary embolism, are randomized to receive either a below-knee or a full-leg graduated compression (30-40 mm Hg at the ankle) elastic stocking for prevention of the post-thrombotic syndrome (PTS). All patients are followed up to three years to assess the development of the PTS, defined according to a validated clinical score (the Villalta scale). The rate of PTS is compared between the two study groups. In addition, there is an assessment of patients' compliance and tolerability of the two different devices.


Eligibility criteria: Inclusion Criteria:

* First episode of proximal deep vein thrombosis, as shown by compression ultrasound

Exclusion Criteria:

* Previous ipsilateral deep vein thrombosis
* Preexisting chronic venous insufficiency
* Bilateral deep vein thrombosis
* Life expectancy lower than 1 year
* Severe arteriopathy of the lower limbs
* Known allergy to elastic stockings
* Lack of written informed consensus

Primary outcomes:
Secondary outcomes:
Other outcomes:
Locations:
city: Padua
country: Italy
facility: Department of Medical and Surgical Sciences, 2nd Chair of Internal Medicine, University of Padua
Study officials:
affiliation: Department of Medical and Surgical Sciences, University of Padua, Italy
name: Paolo Prandoni, MD, PhD
role: PRINCIPAL_INVESTIGATOR
References:
citation: Prandoni P, Noventa F, Quintavalla R, Bova C, Cosmi B, Siragusa S, Bucherini E, Astorri F, Cuppini S, Dalla Valle F, Lensing AW, Prins MH, Villalta S; Canano Investigators. Thigh-length versus below-knee compression elastic stockings for prevention of the postthrombotic syndrome in patients with proximal-venous thrombosis: a randomized trial. Blood. 2012 Feb 9;119(6):1561-5. doi: 10.1182/blood-2011-11-391961. Epub 2011 Dec 16.
Clinical trial NCT00575575: Research on Suicidal Ideation of University Students in Harbin City and Cognitive Behavior Therapy
Official title: the Research on Suicidal Ideation of University Students in Harbin City and Intervention on Them
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Suicide
Keywords: Suicidal ideation
cognitive behavior therapy
Lead sponsor: Harbin Medical University
Sponsor class: OTHER
First posted: 2007-12-18
Enrollment: 355
Sex: ALL
Minimum age (years): 17
Maximum age (years): 35
Standard ages: CHILD
ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: PREVENTION

Brief summary: The purposes of this research are:

* to understand the status of suicidal ideation, suicidal behavior, and depression in Harbin University students; and
* to analyse the infect factors of suicidal ideation and suicidal behavior.

With cognitive behavior interventions on students with suicidal ideation, suicidal behavior, and middle or high degree of depression, the researchers can provide a scientific and effective intervention to the students.

Cognitive therapy for the prevention of suicide attempts: a randomized controlled trial.

Brown GK, Ten Have T, Henriques GR, Xie SX, Hollander JE, Beck AT. Department of Psychiatry, University of Pennsylvania, Philadelphia 19104, USA. gregbrow@mail.med.upenn.edu JAMA. 2005 Aug 3;294(5):563-70.

Detailed description: By using suicidal ideation scale, to assess the status of suicidal ideation and suicidal attempt in 6000 university students in Harbin city. About 300 students with suicidal ideation and depression disorder randomized into two groups (control and intervention groups) accept the cognitive behavior intervention. We will assess the depression after intervention.

Eligibility criteria: Inclusion Criteria:

* Suicidal ideation or the scores of Beck Depression Inventory ≧14

Exclusion Criteria:

* have no Suicidal ideation and the scores of Beck Depression Inventory \<14

Primary outcomes:
measure: suicidal ideation; depression
timeFrame: half a year
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
affiliation: Harbin Medical University
name: Yanjie Yang, doctor
role: STUDY_DIRECTOR
References:
Clinical trial NCT02530775: "Is Instrumentation Necessary for "Static" Degenerative Spondylolisthesis"
Official title: "Is Instrumentation Necessary for "Static" Degenerative Spondylolisthesis - A Prospective Randomized Clinical Study"
Study type: INTERVENTIONAL
Overall status: WITHDRAWN
Phase: NA
Conditions: Degenerative Spondylolisthesis
Spinal Stenosis
Lead sponsor: University of Pittsburgh
Sponsor class: OTHER
First posted: 2015-08-21
Enrollment: 0
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: CROSSOVER
Primary purpose: TREATMENT

Brief summary: The purpose of this study is to determine whether instrumented lumbar fusion provides superior clinical outcomes in comparison to non-instrumented fusion in patients with "static" degenerative spondylolisthesis.

Detailed description: This study will determine whether instrumented lumbar fusion will provide superior clinical outcomes in comparison to non-instrumented fusion in patients with "STATIC" degenerative spondylolisthesis. At the time of scheduling surgery, patients who meet the inclusion/exclusion criteria will be asked to participate. Patients who agree, will be randomized to either non-instrumented or instrumented arthrodesis group. Intra-operative, peri-operative, and post-operative data will be collected and compared. The investigators predict to get very similar clinical outcomes between the two groups, with possibly less complications from the non-instrumented group and definitely a reduction in cost compared to the instrumented group.

Eligibility criteria: Inclusion Criteria:

1. Patients with stable L4-5 spondylolisthesis on lumbar flexion and extension radiographs. Stability will be determined by the treating physician.
2. Patients with concomitant spinal stenosis.
3. Laminectomy at any lumbar levels of stenosis.
4. Fusion only at L4-5 level.

Exclusion Criteria:

1. Prior lumbar spine surgery
2. Multi-level spondylolisthesis
3. Anterior interbody work/fusion
4. Tumor
5. Infection
6. Trauma

Primary outcomes:
measure: Functional Outcome Scores: SF-12/SF-36 Quality of Life Questionnaires
timeFrame: Up to 2 years
measure: Functional Outcome Scores: Oswestry Disability Index (ODI) Questionnaire
timeFrame: Up to 2 years
Secondary outcomes:
measure: Rate of Infection
timeFrame: Expected average of 4 weeks
measure: Rate of Symptomatic Pseudoarthrosis
timeFrame: Up to 2 years
measure: Need for Revision Surgery
timeFrame: Up to 2 years
measure: Length of Hospital Stay
timeFrame: Expected average of 1 week
measure: Surgical Time
timeFrame: 2-4 hours
Other outcomes:
Locations:
Study officials:
affiliation: University of Pittsburgh Medical Center
name: Joon Y Lee, M.D.
role: PRINCIPAL_INVESTIGATOR
References: