Clinical trial NCT02706496: Age-related Changes in Posture Control and Cortex Activity Under a Dynamic Perturbation
Official title: Age-related Changes in Posture Control and Cortex Activity Under a Dynamic Perturbation
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Aging
Keywords: aging of elderly
falling prevention
electroencephalography
postural control
biomechanics
Lead sponsor: Taipei Veterans General Hospital, Taiwan
Sponsor class: OTHER_GOV
Collaborators: name: Ministry of Science and Technology, Taiwan
First posted: 2016-03-11
Enrollment: 37
Sex: ALL
Minimum age (years): 20
Maximum age (years): 74
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: The volunteers from the community will be recruited in this study, the inclusion criterion contained: able to walk and climb the stairs without assistive devices, could follow the instructions, and without well-known balance related diseases or impairments. With the disease of cardiac and pulmonary system, neuromusculoskeletal system, vision, vestibular apparatus, dizziness experience or cognitive deficit would be excluded the study.

Brief summary: With aging, the elderly decreased ability to control postural balance will be accompanied by increased risk of falling (Berg et al, 1992;. Tinetti et al, 1988). According to previous studies, it showed that the elderly over 65 years fall each year probability was 30 %, and it increased with age (Skelton, \& Todd, 2004). In view of this, age-related posture control has become important issues of modern preventive medicine and family care.

Detailed description: Many clinical studies have been developed assessment tools and measurements for clinical staff to provide balanced assessment and intervention. However, the factors of affecting postural control are diverse and complex, not all tools or measurement could effectively detect a risk of falling. In daily living, the postural control involved integration of sensation, biofeedback, movement response, and kinesthetic sense to maintain postural stability, and finally integrated into the neuromuscular system and coordination to help achieve the perfect postural control. Current clinical tools used to assess the fall or research methods to detect the incidence of falls and the lack of effective relevant and contradictory, and it's difficult to effectively evaluate the risk of falls (Gates, et al, 2008).

With the development of postural balance issues associated with aging process in older people, there is no set of standardized equipment, and lack of effective methods for the assessment of normal and older people who fall. In response to these problems, if we can provide a virtual reality interfaces, and with daily living activities as gait, across obstacles activity, sit to stand, will be able to better meet the desire to explore the issue of real significance to enhance researchers for aging, motion analysis, and brain cortex activity mechanism in postural control mechanism.

Eligibility criteria: Inclusion Criteria:

* able to walk and climb the stairs without assistive devices,
* could follow the instructions, and
* without well-known balance related diseases or impairments.

Exclusion Criteria:

* With the disease of cardiac and pulmonary system, neuromusculoskeletal system, vision, vestibular apparatus, dizziness experience or cognitive deficit would be excluded the study.

Primary outcomes:
measure: center of pressure
timeFrame: 3 minutes for 20 trial
Secondary outcomes:
measure: cortex power spectrum density
timeFrame: 3 minutes for 20 trial
Other outcomes:
Locations:
city: Taipei
country: Taiwan
facility: Taipei Veterans General Hospital
Study officials:
affiliation: Taipei Veterans General Hospital, Taiwan
name: Tsui-Fen Yang, MD
role: PRINCIPAL_INVESTIGATOR
References:
citation: Mierau A, Hulsdunker T, Struder HK. Changes in cortical activity associated with adaptive behavior during repeated balance perturbation of unpredictable timing. Front Behav Neurosci. 2015 Oct 14;9:272. doi: 10.3389/fnbeh.2015.00272. eCollection 2015.