Clinical trial NCT05891574: Influence and Relationships Between Square-stepping Exercise and Brain Activation, Cognitive Function, Physical Performance in Healthy Older Adults
Official title: Influence and Relationships Between Square-stepping Exercise and Brain Activation, Cognitive Function, Physical Performance in Healthy Older Adults
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Older Adults
Age Problem
Keywords: older adults
square-stepping exercise
brain activation
Lead sponsor: National Yang Ming Chiao Tung University
Sponsor class: OTHER
First posted: 2023-06-07
Enrollment: 50
Sex: ALL
Minimum age (years): 65
Maximum age (years): 90
Standard ages: OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: OTHER
Time perspective: CROSS_SECTIONAL
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Healthy older adults

Brief summary: Background and purposes: Square-stepping exercise (SSE) has been proved to be an effective intervention for motor and cognitive function in older adults. However, the underlying mechanism of SSE still remains undetermined. Therefore, the aim of this study is to elucidate the possible mechanism of SSE in healthy older adults.

Methods: This is a cross-sectional study. Inclusion criteria are: (1) age between 65 and 90 years, (2) no frailty indicated by Fried frailty criteria, (3) mini-mental state examination score≧24 and Montreal Cognitive Assessment score≧26, (4) ability to walk independently for 1 min. Brain activation differences between SSE patterns and usual walking, as well as relationships between brain activity, cognitive function, physical performance and SSE performance will be examined. This study will address both cognitive and motor aspects of possible mechanism in SSE. SPSS version 25.0 (SPSS Inc., Chicago, IL, USA) will be used to analyze the collected data in this study. One-way ANOVA with repeated measures is used to evaluate the differences in brain activation among usual walking, SSE-pattern 1, and SSE-pattern 2, with Bonferroni test for post hoc analysis. The Pearson correlation coefficient will be used to establish the relationships between brain activity and SSEs performance, between cognitive function and SSEs performance, and between motor function and SSEs performance. The significant level is set at p\< .05.


Eligibility criteria: Inclusion Criteria:

* Age between 65 and 90 years
* No frailty indicated by Fried frailty criteria
* Mini-mental state examination score equals to or more than 24, and Montreal Cognitive Assessment score equals to or more than 26
* Ability to walk independently for 1 min

Exclusion Criteria:

* Central nervous system disorders (such as stroke, Parkinson's disease, spinal cord injury)
* Any unstable physical condition, psychiatric disorder, and other neurological disorder, or diagnosed with learning disability which may affect participating this study

Primary outcomes:
measure: Brain activity
timeFrame: at the enrollment (1 day)
Secondary outcomes:
measure: SSE performance
timeFrame: at the enrollment (1 day)
measure: Montreal Cognitive Assessment
timeFrame: at the enrollment (1 day)
measure: Trail Making Test
timeFrame: at the enrollment (1 day)
measure: Stroop Color and Word Test
timeFrame: at the enrollment (1 day)
measure: Digit span test
timeFrame: at the enrollment (1 day)
measure: Timed up and go test
timeFrame: at the enrollment (1 day)
measure: Berg balance scale
timeFrame: at the enrollment (1 day)
measure: Five times sit to stand test
timeFrame: at the enrollment (1 day)
Other outcomes:
Locations:
city: Taipei
country: Taiwan
facility: National Yang Ming Chiao Tung University
Study officials:
affiliation: National Yang Ming Chiao Tung University
name: Ray-Yau Wang
role: PRINCIPAL_INVESTIGATOR
References: