Clinical trial NCT05046275: MCR Syndrome in Quebec : Results From NuAge Study
Official title: The "Motoric Cognitive Risk" Syndrome in the Quebec Population: Results From the NuAge Study - Sub-study: The Biological Underpinnings of Motoric Cognitive Risk Syndrome: a Multicenter Study
Study type: OBSERVATIONAL
Overall status: ACTIVE_NOT_RECRUITING
Conditions: Motoric Cognitive Risk Syndrome
Aging Disorder
Lead sponsor: Centre integre universitaire de sante et de services sociaux du Centre-Sud-de-l'Île-de-Montréal
Sponsor class: OTHER_GOV
First posted: 2021-09-16
Enrollment: 1741
Sex: ALL
Minimum age (years): 65
Standard ages: OLDER_ADULT
Observational model: COHORT
Time perspective: RETROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: All included participants of NuAge Study were healthy and, in particular, they were cognitively intact at baseline and had no mobility disability.

Brief summary: The overall objective of the proposal is to examine the epidemiology of the newly reported "motoric cognitive risk" (MCR) syndrome, which is a pre-dementia syndrome combining subjective cognitive complaint (i.e.; memory complaint) with objective slow gait speed, in the Quebec elderly population.

Cognition and locomotion are two human abilities controlled by the brain. Their decline is highly prevalent with physiological and pathological aging, and is greater than the simple sum of their respective prevalence, suggesting a complex age-related interplay between cognition and locomotion. Both declines in cognition and locomotion are associated, furthermore the temporal nature of their association has been unclear for a long time. Recently, a systematic review and meta-analysis has provided evidence that poor gait performance predicts dementia and, in particular, has demonstrated that MCR syndrome is a pre-dementia syndrome, suggesting that low gait performance is the first symptom of dementia. The uniqueness of MCR syndrome is that it does not rely on a complex evaluation or laboratory investigations. Indeed, this syndrome combined subjective cognitive complaint and objective slow gait speed, and is easy to apply in population-based settings.

Prevalence and incidence of MCR syndrome, as well as its association with incidence of cognitive decline and impairment, have never been reported in Canada. Nutrition as a determinant of successful aging: The Quebec longitudinal Study (the NuAge study) is a Quebec population-based observational cohort study performed in healthy older community-dwellers adults which provides a unique opportunity to: 1) obtain reliable estimates of MCR syndrome prevalence and incidence, 2) determine the distribution of clinical and biological (blood biomarkers and genetic) characteristics associated with MCR syndrome, 3) examine the association of MCR syndrome and its biological characteristics with cognitive decline and incidence of cognitive impairment in the Quebec elderly population.


Eligibility criteria: Inclusion Criteria:

* All included participants of NuAge Study

Exclusion Criteria:

* no information about cognitive complaint in NuAge database
* no measure of walking speed in NuAge database
* no follow-up completed in NuAge database

Primary outcomes:
measure: prevalence of MCR syndrome
timeFrame: 3 years
Secondary outcomes:
measure: Cognitive decline and impairment
timeFrame: 3 years
measure: Covariates
timeFrame: 3 years
measure: Covariates
timeFrame: 3 years
measure: Covariates
timeFrame: 3 years
measure: Covariates
timeFrame: 3 years
measure: Biological characteristics
timeFrame: 3 years
measure: Genetic approach
timeFrame: 3 years
Other outcomes:
Locations:
city: Montréal
country: Canada
facility: CRIUGM
state: Quebec
Study officials:
References: