Clinical trial NCT06225531: An Autobiographical Memory-Based Intervention for Suicidality
Official title: Exploring the Feasibility and Acceptability of an Autobiographical Memory-Based Intervention for People With Suicidality: A Case Series
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Suicidal Ideation
Mental Health Disorder
Keywords: Suicide
Autobiographical Memory
Lead sponsor: Lancaster University
Sponsor class: OTHER
First posted: 2024-01-26
Enrollment: 3
Sex: ALL
Minimum age (years): 18
Maximum age (years): 65
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: NA
Intervention model: SINGLE_GROUP
Intervention model description: Experimental case series, with a non-concurrent multiple baseline design. This will involve a baseline period which varies in length between participants (3-5 sessions), followed by an intervention period (6 sessions for all)
Primary purpose: OTHER

Brief summary: The study involves a short therapy intervention for people who are experiencing thoughts of suicide. The intervention will focus upon different memories from the person's life. These memories will vary in the emotions they evoke - some memories will be associated with neutral emotions, whereas others will bring up positive emotions. The intervention will have a particular focus upon memories of times when the participants have moved away from thinking about suicide, with the aim of reinforcing memories of what helped them to reconnect with life. The intervention will also introduce relaxation techniques, in addition to involving a safety planning component. The project aims to consider whether this intervention is acceptable and feasible for this population.

Detailed description: This study is looking at whether an autobiographical memory-based intervention is acceptable and suitable for people with thoughts of suicide within a secondary mental health population. Autobiographical memory involves the recollection of past events in a person's own life, and this has been linked to a person's sense of identity, goals, and orientation in the present. Memories linked to negative emotions have been shown to be durable, accessible, and easily and vividly remembered. The power that memories of suicidal ideation and suicide attempts hold is therefore concerning. This intervention aims to support participants to more readily access positive and neutral autobiographical memories, using memory tasks and worksheets. By focusing upon individuals' moves away from suicidal thinking, it also aims to shift the focus onto remembering what led people to reconnect with life.

The study is an experimental case series using a non-concurrent A-B multiple baseline design, in which the participants first attend 3-5 baseline sessions prior to attending 6 intervention sessions. Sessions are one-to-one. The initial baseline session and all intervention sessions will take place face-to-face. The follow-up baseline sessions can be conducted in-person, online via Microsoft Teams, or via telephone, depending on participant preference.

The initial baseline session will involve assessing risk and updating participants' safety plan. The intervention involves 6 sessions of approximately one hour. The first session will focus upon familiarisation to concepts in the intervention, using imagery-based metaphors to support understanding. Sessions 2-4 will focus on different memories - neutral, positive, and memories of moves away from suicidal thinking. Memory tasks will broadly follow the 5 stages outlined in the broad-minded affective coping (BMAC) procedure, but with a focus on these specific memories. In the final 2 sessions, participants will have a choice around which memory to focus on. The final session will also involve post-intervention planning. Outcome measures will be completed in all baseline and intervention sessions.

The study aims to recruit 5-7 participants from community mental health teams (CMHTs) in which supervisory support can be arranged. The intervention will be conducted by the principle investigator (AP), a trainee psychologist, under the supervision of clinical psychologists within the CMHTs (JK and NI) who are also members of the research team.

Eligibility criteria: Inclusion Criteria:

* Individual has experienced suicidal ideation and/or suicidal behaviours within the previous 3 months. This will be screened for by asking the questions:

  1. Have you had thoughts or images of ending your life within the past three months? or
  2. Have you attempted to end your life within the past 3 months?
* Currently under a Community Mental Health Team (CMHT) within which supervisory support can be arranged.

Exclusion Criteria:

* Moderate/severe learning disability
* Organic cerebral disease/injury which significantly affects language comprehension or expression
* Non-English speaking
* Acute psychosis which would affect engagement
* Receiving psychological treatment or participating in another research intervention
* At imminent risk of acting upon thoughts of suicide or of harm to others. This will be screened for by assessing for the presence of active intent or plans to harm themselves or others within the next month. If these individuals consent to be contacted again after a month, the researcher will consider approaching them again to assess for changes to imminent risk. If the individual met the eligibility criteria at this point, the individual would be invited to take part in the study.
* A history of violence or harm to others to a degree in which clinicians have assessed one-to-one sessions to be unsafe
* Currently within an inpatient setting or open to a home-based treatment team.

Primary outcomes:
measure: Acceptability - Therapeutic Alliance
timeFrame: Up to 14 weeks
measure: Acceptability - Adverse effects
timeFrame: Up to 14 weeks
measure: Acceptability - Clinical Global Impression
timeFrame: Up to 14 weeks
measure: Acceptability - Overall
timeFrame: Up to 14 weeks
measure: Acceptability - Qualitative Feedback
timeFrame: Up to 14 weeks
measure: Feasibility - rates of recruitment, attendance, and completion
timeFrame: Up to 14 weeks
Secondary outcomes:
measure: Suicidality
timeFrame: Up to 14 weeks
measure: Entrapment
timeFrame: Up to 14 weeks
measure: Perceived Burdensomeness / Thwarted Belonging
timeFrame: Up to 14 weeks
Other outcomes:
measure: Sessional Mood Scale
timeFrame: Up to 14 weeks
Locations:
city: Manchester
country: United Kingdom
facility: Greater Manchester Mental Health NHS Foundation Trust
Study officials:
affiliation: Lancaster University
name: James Kelly, ClinPsyD
role: PRINCIPAL_INVESTIGATOR
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