Clinical trial NCT01062386: Malaria Survey in Mbarara District, Uganda 2010
Official title: The Epidemiology of Malaria Among Children Under Five in Mbarara District, Uganda - A Cross-sectional Population-based Survey 2010
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Malaria
Keywords: prevalence
transmission
knowledge
attitude
practice
Lead sponsor: Epicentre
Sponsor class: OTHER
Collaborators: name: Medecins Sans Frontieres, Netherlands
First posted: 2010-02-04
Enrollment: 2320
Sex: ALL
Minimum age (years): 1
Maximum age (years): 59
Standard ages: CHILD
Accepts healthy volunteers: yes
Observational model: COHORT
Time perspective: CROSS_SECTIONAL
Sampling method: PROBABILITY_SAMPLE
Study population: Children living in Great Mbarara district

Brief summary: Malaria is one of the major public health problems in Sub-Saharan Africa. In response to this threat, Roll Back Malaria (RBM) has rolled back a strategy using ACT as first line therapy for malaria episode, a wide distribution of Insecticide Treated Bednet (ITN), intermittent presumptive treatment of pregnant women and indoor residual spraying. Recent epidemiological observations suggested a decline in malaria prevalence in some countries but further evidences are still needed to confirm this evolution. The RBM strategy requires the use of reliable rapid diagnostic test (RDT) for which an operational assessment is necessary. Lastly, home-based management of malaria is also an important compound of this strategy. However, a better understanding of the actual use of antimalarial drugs, of the use of bednet and of the barrier to the use of health care is important to implement good quality strategies for malaria control.

This study is a cross-sectional community based survey made of two rounds (one in January 2010 and the second in June 2010). The general objective is to measure the prevalence of infection with Plasmodium falciparum at two periods of the year (at the moment of lowest and highest transmission based on the seasonal rainfalls) and to compare it with the prevalence estimated in 2004 after the rainy season for the same area. Specific objective are the estimation of the prevalence by age stratum, the analysis of the geographical distribution of the infection, the description of the parasitological characteristics, the assessment of three RDT, the description and the analysis of the prevention and care seek behaviours related to malaria.

The study area is the great Mbarara district located in south-west of Uganda. A three-stage cluster sampling method will be used. Spatial information will be collected with global positioning system and imported to Geographical Information System. Behaviour information will be collected through face to face interview.


Eligibility criteria: Inclusion Criteria:

* Males and females
* Ages 1 month to 59 months

Exclusion Criteria:

* None

Primary outcomes:
measure: Proportion of malaria infections in children under 5 years of age
timeFrame: January-February 2010
Secondary outcomes:
measure: Proportion of families with knowledge, attitude and practice regarding malaria prevention
timeFrame: January-February 2010
Other outcomes:
Locations:
city: Mbarara
country: Uganda
facility: Greater Mbarara district
Study officials:
affiliation: Epicentre
name: Carolyn Nabasumba
role: PRINCIPAL_INVESTIGATOR
References: