Clinical trial NCT05042739: Early Identification and Predictive Parsing for High Risk Group of Schizophrenia
Official title: Early Identification and Predictive Parsing for High Risk Group of Schizophr
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: High Risk Group of Schizophrenia
Keywords: Psychosis; UHR; CAARMS;SIPS; BSABS
Lead sponsor: Wuhan Mental Health Centre
Sponsor class: OTHER
Collaborators: name: Health Commission of Hubei Province
First posted: 2021-09-13
Enrollment: 189
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: FAMILY_BASED
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: All are immediate family and three-generation blood kinship of patients with schizophrenia diagnosed in Affiliated Wuhan Mental Health Center, Tongji Medical College of Huazhong University of Science \& Technology.

Subjects are recruited from Wuhan Mental Health Center who can be contacted by telephone or an internet homepage.

Brief summary: An accurate identification of individuals at ultra-high risk (UHR) based on psychometric tools to prospectively identify psychosis as early as possible is required for indicated preventive intervention. The diagnostic comparability of several psychometric tools is unknown. To address the psychometric comparability of the CAARMS, SIPS and BSABS for subjects who are the immediate family and three-generation blood kinship of patients with schizophrenia. To verify the viability and reliability of the three instruments for these subjects. subjects who all are immediate family and three-generation blood kinship of patients with schizophreniawere interviewed. All the subjects were assessed for a UHR state by three psychometric tools including CAARMS, SIPS and BSABS. The psychometric diagnosis results including at risk of psychosis (UHR+), not at risk of psychosis (UHR-), and Psychosis. Demographic and clinical characteristics interviewed by these three instruments were also measured. The inter-rater agreement was assessed for evaluation of the coherence of the three scales. Transition rates of CAARMS, SIPS and BSABS for UCH+ subjects within 2 years were also recorded.There is good diagnostic agreement between the CAARMS, SIPS and BSABS towards identification of UHR subjects who are immediate family and three-generation blood kinship of patients with schizophrenia. Also, these three instruments are reliable and valid for assessing and detecting at risk mental states in these subjects.


Eligibility criteria: Inclusion Criteria:

* all are immediate family and three-generation blood kinship of patients with schizophrenia

Exclusion Criteria:

-

Primary outcomes:
measure: The overall agreement percent
timeFrame: 2 years
measure: the inter-rater reliability
timeFrame: 2 years
measure: the transition rates of UHR+ to psychosis within 2 years
timeFrame: 2 years
Secondary outcomes:
Other outcomes:
Locations:
city: Wuhan
country: China
facility: Dept. of Psychological Rehabilitation, Affiliated Wuhan Mental Health Center, Tongji Medical College of Huazhong University of Science & Technology
state: Hubei
Study officials:
affiliation: Dept. of Psychological Rehabilitation, Affiliated Wuhan Mental Health Center, Tongji Medical College of Huazhong University of Science & Technology
name: Peng Wang, Master
role: PRINCIPAL_INVESTIGATOR
References: