Clinical trial NCT04156386: Vegan or Animal Protein Ingestion on the Recovery of Muscle Function Following Exercise
Official title: The Effect of Vegan or Animal Protein Ingestion on the Recovery of Skeletal Muscle Function Following Strenuous Exercise
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Muscle Recovery
Keywords: Muscle Strength
Musculoskeletal Physiology
Muscle, Skeletal
Whey Proteins
Plant Proteins
Dietary supplements
Lead sponsor: University of Exeter
Sponsor class: OTHER
Collaborators: name: Beachbody
First posted: 2019-11-07
Enrollment: 30
Sex: ALL
Minimum age (years): 18
Maximum age (years): 40
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: OTHER

Brief summary: This study will assess the effect of daily post-exercise vegan (pea) and animal (whey) protein ingestion compared to placebo over 7 days of recovery from strenuous exercise. Muscle strength and soreness will be measured daily, and mechanisms underpinning recovery will be investigated in muscle biopsies taken 3, 24 and 48 hours after exercise.

Detailed description: Strenuous exercise can cause muscle soreness and reduced muscle strength. It is widely acknowledged that nutritional supplements derived from animal protein sources, including whey from milk, aids recovery when taken immediately after strenuous exercise. However, the effect of vegan protein supplements are less understood, and how they affect recovery of strength and soreness is not known. This is an important area of research due to the increasing demand for plant-based protein.

Eligibility criteria: Inclusion Criteria:

* Recreationally active
* 18-40 years of age

Exclusion Criteria:

* Regular and structured involvement in resistance training
* Inactive participants
* Habitual dietary protein intake \<0.8g/kg bw/day and \>2.0g/kg bw/day
* Use of nutritional supplements
* Any diagnosed metabolic conditions (diabetes), cardiovascular disease or hypertension
* Current musculoskeletal injury
* Use of anti-inflammatory medicines
* Individuals with non -removable metallic implants (including heart pacemaker, cochlea implants, medication pumps, surgical clips, plates or screws) or claustrophobia
* Individuals with an allergy to egg, fish, wheat or soy ingredients as the product is manufactured in a facility that contains these ingredients

Primary outcomes:
measure: Change in isokinetic work (W30) performed before and every 24 h after performing 300 maximal eccentric quadriceps contractions.
timeFrame: Once per 24 hour period for 7 days
Secondary outcomes:
measure: Perceived quadriceps muscle soreness
timeFrame: Once per 24 hour period for 7 days
measure: Muscle swelling
timeFrame: Once per 24 hour period for 3 days
measure: Rate of protein incorporation into the muscle
timeFrame: Once per 24 hour period for 3 days
measure: Plasma creatine kinase (CK) activity before and every 24 h after performing 300 maximal eccentric quadriceps contractions.
timeFrame: Once per 24 hour period for 7 days
measure: Change in flow mediated dilation
timeFrame: Once hourly post exercise for 3 hours
Other outcomes:
Locations:
city: Exeter
country: United Kingdom
facility: University of Exeter
Study officials:
affiliation: University of Exeter
name: Francis Stephens
role: PRINCIPAL_INVESTIGATOR
References: