Clinical trial NCT05217875: Prognostic of Dysfunctional Breathing in Long Covid: a Follow up Study
Official title: Prognostic of Dysfunctional Breathing in Long Covid: a Follow up Study
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: COVID-19
Dysfunctional Breathing
Keywords: COVID-19
Dysfunctional breathing
Hyperventilation syndrome
Sighs
erratic breathing
Lead sponsor: Hôpital du Valais
Sponsor class: OTHER
First posted: 2022-02-01
Enrollment: 50
Sex: ALL
Minimum age (years): 14
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: - Patients of 14 years or more diagnosed with DB after COVID-19 using a combined approach of symptoms and CPET in the Hospitals of Sion, of Martigny or Rennaz

Brief summary: Dysfunctional breathing might participate to dyspnoea in long COVID-19. This study investigate the prognosis of patients diagnosed with dysfunctional breathing after SARS-CoV-2 infection in our center.

Detailed description: Dysfunctional breathing (DB) with or without hyperventilation syndrome (HVS) as diagnosed using cardiopulmonary exercise test (CPET) was recently demonstrated as an important physiopathological mechanism of persistent dyspnoea in long COVID patients \[1\]. DB is characterized by specific ventilation pattern on CPET accompanied by respiratory discomfort and/or dyspnea at exercise \[2\]. Most patients with DB will have undergone some sort a specific physiotherapy retraining \[3\]. However the prognostic and the predictors of persistence/resolution of DB after severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection are unknown.

The aim of the study is to determine the prognostic of patients diagnosed with DB after SARS-CoV-2 infection, as well as prognosis factors and predictors of persistence/resolution of DB during a prospective follow up visit.

Eligibility criteria: Inclusion Criteria:

* patients 14 years or more
* diagnosis of DB after SARS-CoV-2 at our long covid clinic using a combined approach of symptoms and CPET analysis in the hospitals of Sion, Martigny or Rennaz
* Inclusion between November 2020 and until the end of October 2021

Exclusion Criteria:

* Refusal to participate
* comorbidities preventing the CPET or PFT to be carried out

Primary outcomes:
measure: Persistence/resolution of dysfunctional breathing at follow-up visit
timeFrame: 6 to 9 monts from diagnosis
Secondary outcomes:
measure: Change in ventilatory patterns (tidal volume [VT], breathing frequency [BF] at isowork as compared with baseline
timeFrame: 6 to 9 monts from diagnosis
measure: Dispersion of VT and BF during the CPET
timeFrame: 6 to 9 monts from diagnosis
measure: Change in ETCO2 and PaCO2
timeFrame: 6 to 9 monts from diagnosis
measure: Qualitative changes (increase/decrease/no change of DB pattern of CPET)
timeFrame: 6 to 9 monts from diagnosis
measure: Score HADS changes
timeFrame: 6 to 9 monts from diagnosis
measure: Score SF-36 changes
timeFrame: 6 to 9 monts from diagnosis
measure: Specific symptom scale changes
timeFrame: 6 to 9 monts from diagnosis
measure: Specific work capacity changes questions
timeFrame: 6 to 9 monts from diagnosis
measure: Post-COVID Functional Status (PCFS) changes
timeFrame: 6 to 9 monts from diagnosis
Other outcomes:
Locations:
city: Martigny
country: Switzerland
facility: Centre hospitalier du valais romand
Study officials:
References: