Clinical trial NCT00318942: Efficacy and Safety of Colloids Versus Crystalloids for Fluid Resuscitation in Critically Ill Patients
Official title: CRISTAL: Colloids Compared to Crystalloids in Fluid Resuscitation of Critically Ill Patients: A Multinational Randomised Controlled Trial
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE3
Conditions: Critical Illness
Keywords: Sepsis
Multiple Trauma
Hypovolemic Shock
Lead sponsor: University of Versailles
Sponsor class: OTHER
Collaborators: name: Assistance Publique - Hôpitaux de Paris
First posted: 2006-04-27
Enrollment: 2857
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: Background: Two recent systematic reviews of the literature and meta-analyses have suggested that colloids administration might be deleterious in critically ill patients.

Objective: To compare the effects on hospital mortality of crystalloids and colloids when given for fluid resuscitation in critically ill patients.

Setting: Adult intensive care units (ICUs) in several European countries.

Study design: A multinational, randomised, controlled trial performed on two parallel groups.

Intervention: Any type of crystalloids (control group) versus any type of colloids (including albumin).

Patients: All patients above the legal age of consent and hospitalised in an intensive care unit, who need fluid resuscitation (according to the physician). Pregnant women, moribund patients, brain dead patients, and patients who have a known allergy to colloids or severe head injury or major burns (\> 20% of body surface) or dehydration will not be included.

Primary endpoint: 28-day mortality.

Hypothesis: Assuming a hospital mortality rate of 20% in the crystalloids group, a 0.05 type I error, 3010 patients are needed to show a difference between the 2 groups of 5% with a 90% probability (two-sided test).

Detailed description: BACKGROUND

Fluid resuscitation is a very common treatment in the ICU, and every day a thousands of critically ill patients are treated around the world with crystalloids or colloids to correct hypovolaemia (1, 2). A wide diversity of fluids is available, and new products are coming in the very near future. In 1989, a French consensus conference recommended to abandon the use of fresh frozen plasma and to limit the use of albumin to very specific situations (e.g. contraindication to other colloids, serum protein levels below 35 g/l) (1). Crystalloids and gelatins were considered as the best solutions for fluid resuscitation in the critically ill. In 1997, as starch was increasingly used, this guidelines were updated (2). It was concluded that isotonic crystalloids are as efficacious as starch pending the amount of fluid to be administered.

Three systematic reviews of the literature provided an accurate summary of data available from randomised controlled trials evaluating human albumin (3), or comparing crystalloids to colloids in fluid resuscitation in critically ill patients (4,5). The first systematic review (3) has analysed 30 randomised trials and concluded that there is no evidence that albumin administration reduces the risk of death in critically ill patients. By contrast, this review suggested that albumin administration might increase by 6% the risk of death. In the Cochrane Injury Review Group systematic review (4), 40 randomised trials were analysed. The authors concluded that the administration of colloids might be associated with an absolute increase of 3.8% in the risk of death. The last review has analysed only 17 randomised trials as they decided to exclude studies of hypertonic saline. This review showed no significant difference in the risk of death between colloids and crystalloids or in other outcomes like prevalence of pulmonary edema and length of stay at the ICU and at the hospital (5). However, when the authors considered only the studies with a high methodological quality score, they observed a nice trend toward an increased survival rate in favour of crystalloids. They reached the same conclusions for the subset of trauma patients.

JUSTIFICATION FOR THE STUDY

It seems reasonable to abandon the use of fresh frozen plasma in fluid resuscitation in critically ill patients. There are no definite criteria to decide which of crystalloids and colloids should be preferred. It is unquestionable that, to achieve a given haemodynamic effect, the amount of crystalloids needed is almost twice the amount of colloids (1, 2). Colloids and crystalloids have different effects on a range of important physiological parameters. As most of the critically ill patients underwent one or more volume replacements, even a small increase in the risk of death (around 5%) has considerable clinical implications. The meta analyses suggested a 5% absolute risk reduction in mortality in favour of crystalloids (4, 5). The number needed to treat, an estimate which is more clinically meaningful (6), is of 20, suggesting about 1 additional death (with colloids) for every 20 patients resuscitated. Given the number of patients exposed to fluid resuscitation, about 60 additional deaths might be observed per year in a ICU,receiving 600 patients a year.

A large trial is needed to compare the safety and efficacy of colloids and crystalloids (4,5).

OBJECTIVES

Primary objective:

To compare the effects on 28-day mortality of colloids versus crystalloids in ICU patients who need fluid resuscitation.

Secondary objectives:

ICU and hospital mortality and morbidity, and safety.

STUDY DESIGN

A multinational, randomised, controlled trial, on two parallel groups.

STUDY TREATMENTS

* Arm A: crystalloids
* Arm B: colloids Allocated treatment must be started immediately after randomisation (Day-0)
* The amount and speed of fluid loading will be at the physicians' discretion. The amount of starch should not exceed 30 ml/kg/24 hours. In case additional volume replacement is necessary, gelatins or albumin may be used. During all ICU stay, the patients will receive only crystalloids or only colloids for fluid resuscitation, according to randomisation.

Double blind seems unfeasible as the time window for inclusion is extremely short (treatment should be available promptly at bedside) and the amounts of volume replacement for all ICU stay could not be predicted a priori.

Allowed co-interventions:

* Any treatment required for a pre-existing condition
* Any type of inotropes or vasopressors
* Red cells, platelets, fresh frozen plasma, which are used should follow general guidelines (2).

Co-interventions not allowed:

Any other volume replacement solution than those above mentioned. Albumin is not allowed in patients allocated to crystalloids unless plasma albumin levels are below 20 g/dl (2).

ENDPOINTS

Main endpoint:

* 28-day mortality rate.

Secondary endpoints:

* ICU and Hospital mortality rates
* Number of ICU days the patient is alive and free of

  * mechanical ventilation,
  * vasopressors and inotropes,
  * renal replacement therapy,
  * organ system failure according to the sequential organ failure assessment (SOFA) scoring system\[7\]
* Total amount of volume replacement
* Difference in

  * AUC of mean arterial pressure between HO and H24 at Day-0
  * weight between Day-0 and Day-1 and Day-2
  * PaO2/FiO2 ratio between H0 and H12 and H24, at Day-0
  * chest X-ray score between day-0 and Day-1 and day-2(8)
* Frequency of adverse events
* Anaphylaxis reaction: skin or mucous rash, nausea, vomiting, shock, bronchial spasm, respiratory or cardiac arrest
* Coagulation disorders: fall in prothrombin time (PT) rate, in factor VIII
* Impairment in renal function: increase in creatinine \> 200 µmol/l
* Length of stay at ICU
* Length of hospital stay

RANDOMISATION

The list of randomisation will be generated by computer. We will use block randomisation stratified by site and diagnosis,

1. trauma or haemorrhage,
2. sepsis,
3. other diagnoses.

Modalities:

* Day of randomisation = Day-0
* The delay between the decision to resuscitate the patients with fluids and randomisation should be as short as possible (15 minutes or less). Thus, the use of sealed envelopes seems to be the best method for allocation concealment in this case. There will be at each centre, 3 sets of sealed envelopes, one for each strata (i.e., trauma or hemorrhage, sepsis, and other diagnoses). To randomise a patient, the investigator must use the first available sealed envelope (according to allocation number) in the corresponding (i.e., trauma or hemorrhage, sepsis, other diagnoses).
* Choice of strata: when a patient has more than one diagnosis, the choice of the strata must be as follows: trauma or haemorrhage \> sepsis \> others. For example, a patient with trauma and sepsis will be randomised in the " trauma " strata.
* An envelope must be used only once.
* Investigators must declare by fax (to the coordinating centre) each inclusion within 2 working days, and provide the following information:

FOLLOW UP

From H0 (time of randomisation) to H24:

* Total amount of each type of fluid infused
* Number of red cell units
* Mean of mean arterial pressure at hourly intervals from H0 to H24
* PaO2/FiO2 ratio at H0, H12 and H24
* SOFA score
* PT time, (worse values)
* Plasma total proteins and albumin levels
* Adverse events (cf. supra)

Daily from Day-1 to ICU discharge:

* Patient's status: dead or alive
* Total amount of each type of fluid infused
* SOFA score
* Number of red cell units
* Surgical procedures
* Specialised radiographic procedures
* Adverse events (cf. supra)
* Chest X-ray score (annexe 6) and weight at Day-1 and day-2

At ICU discharge:

* Alive or date of death
* Length of ICU stay
* Time on mechanical ventilation
* Omega scores 1,2,3 and total (annexe 8 \[14\])
* Number and type of adverse events (cf. supra)
* Where the patient is discharged to: home, another ward in the same hospital, another hospital, rehabilitation centre, home for disabled people

At hospital discharge (if not the same as that of ICU discharge):

* Alive or date of death
* Length of hospital stay
* Where the patient is discharged to: home, another ward in the same hospital, another hospital, rehabilitation centre, home for disabled people

SAMPLE SIZE

This study is designed to show an absolute difference of 5% in 28-day mortality between colloids and crystalloids. Assuming a mortality rate of 20% in the crystalloids group, with alpha = 5% and beta = 10%, 1504 patients per treatment arm are needed. A total of 3010 patients will be enrolled. All randomised patients must be followed up (at least) till ICU discharge. One hundred active centres will be recruited in Europe. The participation of each centre will be around 3 to 6 months.

STATISTICAL ANALYSIS

Interim analyses and stopping rules

The boundaries of the sequential plan are drawn to demonstrate an absolute difference of 5% in 28-day mortality rate between the two treatment arms, assuming a 20% mortality rate in the crystalloids group, and with alpha and beta of 5% and 10% respectively. The analyses will be performed every 100 deaths. The figure displays the boundaries of the sequential plan. Briefly, Z represents the difference between the two groups and V the number of patients that have been included. When a boundary is crossed, the enrollments in the study must be stopped, and the conclusion depends on which boundary has been crossed (see figure). Simulations allow to estimate how many inclusions are saved: when difference in mortality rates is nil, 1109 patients have to be included to reach the conclusion. When difference is 5%, 1477 patients have to be included to reach the conclusion.

Final analysis

The final analysis will be performed according to the intention to treat principle, after inclusions in the study will be stopped.

Baseline characteristics of patients will be compared between the two treatment arms: categorical variables will be expressed as number and percentage and compared by Chi-2 tests, means, standard deviation, and range will be given for continuous variables, which will be compared by Student t tests.

Methods for analyses of efficacy and safety will depend on the type of outcome. Survival curves will be constructed according to the Kaplan-Meyer method, and compared by log-rank tests. The comparison will be adjusted the main prognosis variables with Cox models. Categorical variables will be compared by Chi-2 tests, and continuous variables Student t tests or analysis of variance for repeated measures.

STUDY ORGANISATION

Steering committee

PI: Djillali Annane (Garches), Statistician: Sylvie Chevret (Paris) Yves Cohen (Avicenne), Samir Jaber (Montpellier), Gilles Troché (Versailles) Fékri Abroug (Monastir, Tunisie) Olivier Lesur (Sherbrook, Canada),

Advisory Board:

Jean François Baron, François Feihl (Lausanne, Suisse), Jean Louis Vincent (Bruxelles, Belgique)

Safety and Efficacy Monitoring Board:

Edward Abraham (Birmingham, USA), Déborah Cook (Hamilton, Canada), Mervyn Singer (London, UK), Charles Sprung (Jérusalem, Israel)

Eligibility criteria: Inclusion Criteria:

* Males and females, above the legal age of consent
* Hospitalized in intensive care unit
* Need fluid resuscitation (according to the physician in charge of the patient)

Exclusion Criteria:

Patients who have one or more of the following items:

* Known allergy to gelatins, albumin or starch
* Coagulation disorders (haemophilia, Willebrand disease, etc.)
* Chronic renal failure on permanent dialysis
* Severe hepatic failure
* Burns \> 20 % of body surface
* Pregnancy
* Volume replacement: As a part of anaesthesia, for anaphylactic shock, or for dehydration
* Brain death
* Advance directive of withholding or withdrawal of life-sustaining treatments
* Any other investigational drugs

Primary outcomes:
measure: 28-day mortality
timeFrame: Day 28
Secondary outcomes:
measure: ICU and hospital mortality rates
timeFrame: Day 90
measure: Number of days free of mechanical ventilation (MV), vasopressors, renal replacement therapy, and organ system failure
timeFrame: Day 90
measure: Difference in the area under the curve (AUC) of mean arterial pressure (MAP) from HO to H24, in weight gain, in PaO2/FiO2 ratio, chest X-ray score
timeFrame: Day 2
measure: Frequency of adverse events
timeFrame: day 90
measure: Length of stay (LOS)
timeFrame: Day 90
Other outcomes:
Locations:
city: Brussels
country: Belgium
facility: Hôpital Erasme
city: Fleurimont
country: Canada
facility: CHU de Sherbrooke-Höpital Fleurimont
city: Quebec
country: Canada
facility: Hôpital Charles LeMoyne
city: Angers
country: France
facility: CH d'Angers
city: Annecy
country: France
facility: Centre Hospitalier d'Annecy
city: Arles
country: France
facility: CH Joseph Imbert
city: Arpajon
country: France
facility: CH d'Arpajon
city: Bastia
country: France
facility: CHG de Bastia
city: Bobigny
country: France
facility: Hôpital Avicenne
city: Bordeaux
country: France
facility: CH Pellegrin Tripode
city: Brest
country: France
facility: Hôpital Cavale Blanche
city: Briancon
country: France
facility: Chg Briancon
city: Clamart
country: France
facility: HIA Percy
city: Clamart
country: France
facility: Hôpital A. Beclere
city: Corbeil Essonnes
country: France
facility: Hôpital Corbeil Essonnes
city: Creteil
country: France
facility: Hôpital Henri Mondor
city: Dijon
country: France
facility: Hôpital Général
city: Dourdan
country: France
facility: CH Dourdan
city: Etampes
country: France
facility: Centre Hospitalier d'Etampes
city: Freyming Merlebach
country: France
facility: Hôpital de FREYMING-MERLEBACH
city: Garches
country: France
facility: Hôpital Raymond Poincaré
city: La Roche Sur Yon
country: France
facility: CHR
city: Le Chesnay
country: France
facility: Hôpital A. Mignot
city: Liege
country: France
facility: CHU Liege
city: Lille
country: France
facility: Hôpital Claude Huriez
city: Limoges
country: France
facility: CH Dupuytren
city: Lyon
country: France
facility: Centre Régional Léon Bernard
city: Lyon
country: France
facility: Hôpital Louis Pradel
city: Meaux
country: France
facility: CH MEAUX
city: Montpellier
country: France
facility: Hôpital Saint Eloi
city: Mulhouse
country: France
facility: Centre Hospitalier de Mulhouse
city: Nancy
country: France
facility: Hôpital Central
city: Nancy
country: France
facility: Hôpital Central NANCY
city: Nancy
country: France
facility: Polyclinique de Gentilly
city: Orléans
country: France
facility: CHRG d'Orléans
city: Paris
country: France
facility: HEGP
city: Paris
country: France
facility: Hôpital Bichat Claude Bernard
city: Paris
country: France
facility: Hôpital Bicêtre
city: Paris
country: France
facility: Hôpital la Pitié Salpétrière
city: Paris
country: France
facility: Hôpital Lariboisière
city: Paris
country: France
facility: Hôpital Saint Louis
city: Paris
country: France
facility: Hôpital TENON
city: Paris
country: France
facility: Hôtel Dieu
city: Pessac
country: France
facility: CHU de Bordeaux
city: Pierre Benite
country: France
facility: Chu Lyon Sud
city: Poissy
country: France
facility: CHI Poissy
city: Poitiers
country: France
facility: CHU de Poitiers
city: Pontoise
country: France
facility: Centre Hospitalier R. Dubos
city: Quincy Sous Senart
country: France
facility: CH Claude Galien
city: Reims
country: France
facility: Chu Reims
city: Rennes
country: France
facility: CHU Rennes
city: Roubaix
country: France
facility: CH Victor Provo
city: Rouen
country: France
facility: Hôpital Charles Nicolle
city: Saint Denis
country: France
facility: Centre Cardiologique du Nord
city: Saint Germain en Laye
country: France
facility: CHI Saint Germain en Laye
city: Saint Lo
country: France
facility: CH Mémorial SAINT LO
city: Soissons
country: France
facility: CHG de SOISSONS
city: Strasbourg
country: France
facility: Hôpital Civil
city: Strasbourg
country: France
facility: Hôpital Hautepierre
city: Thionville
country: France
facility: CHR Bel Air
city: Toulouse
country: France
facility: CHU Toulouse
city: Valence
country: France
facility: CHG Valence
city: Vandoeuvre Les Nancy
country: France
facility: CHU Brabois Nancy
city: Mahdia
country: Tunisia
facility: Hôpital T Sfar
city: Monastir
country: Tunisia
facility: Chu Bourguiba
city: Tunis
country: Tunisia
facility: Hôpital A Mami
city: London
country: United Kingdom
facility: Homerton University Hospital
Study officials:
affiliation: Assistance Publique Hôpitaux de Paris - University of Versailles
name: Djillali Annane, MD, PhD
role: STUDY_CHAIR
References:
citation: Annane D, Siami S, Jaber S, Martin C, Elatrous S, Declere AD, Preiser JC, Outin H, Troche G, Charpentier C, Trouillet JL, Kimmoun A, Forceville X, Darmon M, Lesur O, Reignier J, Abroug F, Berger P, Clec'h C, Cousson J, Thibault L, Chevret S; CRISTAL Investigators. Effects of fluid resuscitation with colloids vs crystalloids on mortality in critically ill patients presenting with hypovolemic shock: the CRISTAL randomized trial. JAMA. 2013 Nov 6;310(17):1809-17. doi: 10.1001/jama.2013.280502.
citation: Heming N, Elatrous S, Jaber S, Dumenil AS, Cousson J, Forceville X, Kimmoun A, Trouillet JL, Fichet J, Anguel N, Darmon M, Martin C, Chevret S, Annane D; CRISTAL Investigators. Haemodynamic response to crystalloids or colloids in shock: an exploratory subgroup analysis of a randomised controlled trial. BMJ Open. 2017 Oct 6;7(10):e016736. doi: 10.1136/bmjopen-2017-016736.