Clinical trial NCT06299241: Evaluation of Physical Performance in Old Adults With Sarcopenic Obesity
Official title: Evaluation of Physical Performance in Old Adults With Sarcopenic Obesity
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Obesity
Sarcopenia
Keywords: Aging
Obesity
Sarcopenia
Physical performance
Lead sponsor: Istituto Auxologico Italiano
Sponsor class: OTHER
First posted: 2024-03-07
Enrollment: 80
Sex: ALL
Minimum age (years): 60
Maximum age (years): 85
Standard ages: ADULT
OLDER_ADULT
Observational model: COHORT
Time perspective: CROSS_SECTIONAL
Sampling method: PROBABILITY_SAMPLE
Study population: Obese patients (BMI \> 35), of both genders, aged \> 60 years, hospitalized at San Giuseppe Hospital, Istituto Auxologico Italiano, IRCCS, Piancavallo (VB), Italy for a multidisciplinary 3-week body weight reduction program.

Brief summary: The primary objectives of the present study are to estimate the sarcopenic proportion in a cohort of obese older subjects who have been hospitalized. The secondary objective is to individuate several clinical variables that differ between the sarcopenic obese patient and the not sarcopenic obese patient.

Detailed description: 80 obese patients of both genders (BMI \> 35), with an age \> 60 years, hospitalized at the Hospital San Giuseppe, Istituto Auxologico Italiano, IRCCS, Piancavallo (VB) are selected. For each patient, the following information are collected at the time of admission:

* anthropometric parameters (height, weight, BMI, waist and hip circumference);
* body composition (free fat mass, fat mass), measured with impedance (BIA) and DEXA;
* hand strength measured with the hand grip test;
* explosive strength of lower limbs, measured with the stair climbing test;
* Senior Fitness Test (SFT), a battery of tests useful to estimate the fitness level in the elderly. SFT is a test that leads to measuring different physical parameters typical of daily activities: strength of upper and lower limbs, aerobic resistance, flexibility of lower and upper limbs, agility, and dynamic equilibrium. The measurements obtained make it possible to classify the skills as high function or low function.
* Physical performance test (PPT), which evaluates 7 physical capabilities areas of the subject to perform actions during daily life. The cut-off to determine the motor limitation condition is a score of ≤ 20 (out of 28 points).
* Questionnaire SF-12 (Short Form Health Survey), which leads to a multi-dimensional measuring of the life quality related to health. It is composed of 12 questions from which can be obtained two synthetic indices, one related to physical health and one related to mental health.
* Oswestry Disability Index questionnaire, elaborated to have information on how back problems, or leg problems, can influence physical abilities related to daily life.

The presence of sarcopenia is identified based on the European Working Group on Sarcopenia in Older People (EWGSOP2) (Cruz-Jentoft AJ et al. 2019) definition. The physical performance parameters is evaluated according to the age, sex, obesity grade, and presence of sarcopenic obesity.

Eligibility criteria: Inclusion Criteria:

* obese patients (BMI \> 35),
* both genders
* age \> 60 years
* hospitalization at San Giuseppe Hospital, Istituto Auxologico Italiano, IRCCS, Piancavallo (VB), Italy for a multidisciplinary 3-week body weight reduction program

Exclusion Criteria:

* obese patients with BMI \< 35
* age \< 60 years

Primary outcomes:
measure: Fat free mass
timeFrame: Baseline
measure: Evaluation of lower limb muscle strength
timeFrame: Baseline
measure: Senior Fitness Test (SFT)
timeFrame: Baseline
measure: Physical performance test (PPT)
timeFrame: Baseline
measure: Fat mass
timeFrame: Baseline
Secondary outcomes:
measure: Questionnaire SF-12 (Short Form Health Survey)
timeFrame: Baseline
measure: Oswestry Disability Index questionnaire
timeFrame: Baseline
Other outcomes:
Locations:
city: Oggebbio
country: Italy
facility: Istituto Auxologico Italiano, Site Piancavallo
state: Verbania
Study officials:
References: