Clinical trial NCT02631759: Prevention of Epileptic Seizures in Acute intraCerebral Haemorrhage
Official title: Prevention of Epileptic Seizures in Acute intraCerebral Haemorrhage
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE3
Conditions: Acute intraCerebral Haemorrhage
Keywords: Acute intraCerebral Haemorrhage, Epileptic seizures, Lévétiracetam
Lead sponsor: Hospices Civils de Lyon
Sponsor class: OTHER
First posted: 2015-12-16
Enrollment: 50
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: Haemorrhagic strokes represent about 10-15 % of all strokes and 30,000 cases per year in France. The 30-day death rate ranges from 30 to 55% (50% of deaths occurring within 48 hours). Currently, no urgent medical or surgical treatment has been shown to improve functional or vital prognosis. Clinical epileptic seizures frequency in acute intracerebral haemorrhage has been estimated between 4% and 16% but the occurrence of subclinical epileptic seizures (detected on the electroencephalogram (EEG) only) could be much more frequent (28 % to 40 %).

Some studies have suggested that early repeated epileptic seizures may be associated with a worse neurological prognosis. Repeated epileptic seizures occurring in the acute phase may increase brain oedema, worsen, hypoxia and may lead to cellular death in the injured brain tissue. Thus, prevention of early epileptic seizures may improve neurological outcome. However, the efficacy of a systematic prophylactic antiepileptic treatment on clinical and subclinical epileptic seizures has not been evaluated in the setting of intracerebral haemorrhage. The current European guidelines recommend the use of antiepileptic drugs only when epileptic seizures occur.

Primary objective: PEACH is a randomized controlled trial aiming at evaluating the impact of systematic prophylactic antiepileptic treatment with levetiracetam versus placebo in acute supratentorial spontaneous intracerebral haemorrhage. The primary endpoint is the occurrence of at least one clinical or electrical epileptic seizure recorded on continuous 48h holter EEG.

Secondary Objectives:This study also aims to assess:

Ä The efficacy of prophylactic treatment with levetiracetam on the number of EEG seizures, on the total duration of epileptic seizures continuously recorded on EEG, on the occurrence of some paroxysmal EEG patterns, on the number of clinical seizures occurred during 72 hours of diagnosis, on the occurrence of early (day-0 to day-30 ) and late (from day-30 to 12 months) clinical seizures, on the functional prognosis at 3 , 6 and 12 months evaluated by the modified Rankin scale , on the cerebral oedema and mass effect evaluated by comparing the admission brain CT scan with the control CT scan performed at 72 hours, on the neurological status as assessed by the National Institute of Health Stroke Scale at 72 hours , 1 month and 3 months and on the quality of life measured by the Stroke impact Scale at 3, 6 and 12 months.

Ä The frequency of side effects related to treatment with levetiracetam (anxiety and depression assessed by the Hospital Anxiety and Depression Scale at 1 and 3 months) Sample Size: 104 patients will be recruited over 2 years.


Eligibility criteria: Inclusion Criteria:

* Age greater than 18 years with no upper age limit
* Competent adult patient.
* Patient affiliated to the French National Health Insurance.
* Patient with supratentorial spontaneous intracerebral hemorrhage diagnosed by CT or MRI
* Early neurological symptoms less than 24 hours
* NIHSS score on admission between 5 and 25
* Informed consent given by the patient or his legal representative

Exclusion Criteria:

* Inaugural Seizures ( at the onset of symptoms associated with intracerebral hemorrhage )
* Seizures occurring between the inclusion of the patient and the start of the EEG
* Other Intracerebral hemorrhage infratentorial , post-traumatic , related to a vascular malformation or an underlying tumor and secondarily hemorrhagic cerebral infarction
* Current antiepileptic treatment when intracerebral hemorrhage , or a history of epilepsy
* Modified Rankin Scale before intracerebral hemorrhage \> 1 (indicating a preexisting disability)
* Serious illness which can affect the prognosis within 3 months
* Severe renal impairment ( creatinine clearance \<30 ml / min)
* Pregnancy, lactation
* Known hypersensitivity to levetiracetam or other pyrrolidone derivatives , or any of the excipients.
* Untreated severe depression , psychotic disorders
* Lactose Intolerance
* Patient under measuring socio- legal protection

Primary outcomes:
measure: Occurrence of at least one clinical or electrical epileptic seizure recorded on continuous 48 hours holter EEG
timeFrame: 48 hours
Secondary outcomes:
measure: Occurrence of electroencephalographic signs
timeFrame: 48 hours
measure: Number of EEG seizures
timeFrame: 48 hours
measure: Total duration of epileptic seizures continuously recorded on EEG
timeFrame: 48 hours
measure: occurrence of some paroxysmal EEG patterns
timeFrame: 48 hours
Other outcomes:
measure: Occurrence of early (day-0 to day-30 ) and late (from day-30 to 12 months) clinical seizures
timeFrame: 12 months
measure: Functional prognosis at 3 , 6 and 12 months evaluated by the modified Rankin scale
timeFrame: 12 months
measure: Cerebral oedema and mass effect evaluated by comparing the admission brain CT scan with the control CT scan performed at 72 hours
timeFrame: 72 hours
measure: Neurological status as assessed by the National Institute of Health Stroke Scale at 72 hours , 1 month and 3 months
timeFrame: 3 months
measure: Quality of life measured by the Stroke impact Scale at 3, 6 and 12 months
timeFrame: 12 months
measure: frequency of side effects related to treatment with levetiracetam (anxiety and depression assessed by the Hospital Anxiety and Depression Scale at 1 and 3 months)
timeFrame: 3 months
Locations:
city: Lyon
country: France
facility: Department of functional neurology and epileptology
Study officials:
affiliation: Hospices Civils de Lyon
name: Laure Peter-Derex, MD
role: STUDY_DIRECTOR
References:
citation: Peter-Derex L, Philippeau F, Garnier P, Andre-Obadia N, Boulogne S, Catenoix H, Convers P, Mazzola L, Gouttard M, Esteban M, Fontaine J, Mechtouff L, Ong E, Cho TH, Nighoghossian N, Perreton N, Termoz A, Haesebaert J, Schott AM, Rabilloud M, Pivot C, Dhelens C, Filip A, Berthezene Y, Rheims S, Boutitie F, Derex L. Safety and efficacy of prophylactic levetiracetam for prevention of epileptic seizures in the acute phase of intracerebral haemorrhage (PEACH): a randomised, double-blind, placebo-controlled, phase 3 trial. Lancet Neurol. 2022 Sep;21(9):781-791. doi: 10.1016/S1474-4422(22)00235-6.