Clinical trial NCT04450134: Histamine H1/H2 Receptors and Training Adaptations
Official title: Role of Histamine H1/H2 Receptors in the Health- and Performance-promoting Adaptations to High-intensity Interval Training
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Exercise Training
Physical Activity
Keywords: Exercise
Physiology
Lead sponsor: University Ghent
Sponsor class: OTHER
Collaborators: name: Research Foundation Flanders
name: University of Copenhagen
First posted: 2020-06-29
Enrollment: 19
Sex: MALE
Minimum age (years): 18
Maximum age (years): 50
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Intervention model description: Placebo + exercise vs histamine blockade + exercise
Primary purpose: BASIC_SCIENCE

Brief summary: Exercise training is beneficial for both health and performance. Histamine has been shown to be involved in the acute exercise response. The current study addresses the role of histamine H1/H2 receptor signaling in the chronic training-induced adaptations. Results from this study will yield more insights into the molecular mechanisms of adaptations to exercise training.


Eligibility criteria: Inclusion Criteria:

* Sedentary or low levels of physical activity
* Caucasian

Exclusion Criteria:

* Chronic diseases
* Medication use
* Smoking
* Excessive alcohol consumption
* Seasonal allergies

Primary outcomes:
measure: Change in cardiorespiratory fitness
timeFrame: Before, after 3 weeks and after 6 weeks of exercise training
measure: Change in peak aerobic power output
timeFrame: Before, after 3 weeks and after 6 weeks of exercise training
measure: Change in whole-body insulin sensitivity
timeFrame: Before and after 6 weeks of exercise training
measure: Change in microvascular function
timeFrame: Before and after 6 weeks of exercise training
Secondary outcomes:
measure: Change in skeletal muscle capillarization
timeFrame: Before and after 6 weeks of exercise training
measure: Change in skeletal muscle enzyme activity
timeFrame: Before and after 6 weeks of exercise training
measure: Change in skeletal muscle protein content
timeFrame: Before and after 6 weeks of exercise training
measure: Change in power output at Gas Exchange Threshold (GET)
timeFrame: Before, after 3 weeks and after 6 weeks of exercise training
measure: Change in power output at Respiratory Compensation Point (RCP)
timeFrame: Before, after 3 weeks and after 6 weeks of exercise training
measure: Change in time to exhaustion performance test
timeFrame: Before, after 3 weeks and after 6 weeks of exercise training
measure: Change in heart rate during submaximal cycling
timeFrame: Before and after 6 weeks of exercise training
measure: Change in substrate oxidation during submaximal cycling
timeFrame: Before and after 6 weeks of exercise training
measure: Change in blood lactate accumulation during submaximal cycling
timeFrame: Before and after 6 weeks of exercise training
measure: Change in cycling efficiency during submaximal cycling
timeFrame: Before and after 6 weeks of exercise training
measure: Change in fasted serum insulin concentrations
timeFrame: Before and after 6 weeks of exercise training
measure: Change in fasted serum glucose concentrations
timeFrame: Before and after 6 weeks of exercise training
measure: Change in fasted serum cholesterol concentrations
timeFrame: Before and after 6 weeks of exercise training
measure: Change in fasted serum triglyceride concentrations
timeFrame: Before and after 6 weeks of exercise training
measure: Change in resting blood pressure
timeFrame: Before and after 6 weeks of exercise training
measure: Change in resting heart rate
timeFrame: Before and after 6 weeks of exercise training
measure: Change in body weight
timeFrame: Before and after 6 weeks of exercise training
Other outcomes:
Locations:
city: Gent
country: Belgium
facility: Department of Movement and Sports Sciences, Ghent University
state: Oost-Vlaanderen
Study officials:
References: