Clinical trial NCT03602170: Cardiovascular Effects of High-Intensity Interval Training (HIIT)
Official title: Cardiovascular Effects of High-Intensity Interval Training (HIIT) and Moderate-Intensity Continuous Training (MCT)
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Healthy Sedentary Adults With BP <140/90
Keywords: High-Intensity Interval Training
Exercise
Cardiovascular Health
Blood Pressure
Lead sponsor: University of Delaware
Sponsor class: OTHER
First posted: 2018-07-26
Enrollment: 20
Sex: ALL
Minimum age (years): 20
Maximum age (years): 44
Standard ages: ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The purpose of this study is to determine the effect of high-intensity interval training (HIIT) in comparison to moderate-intensity continuous training (MCT) on blood pressure, blood vessel function, and blood pressure reactivity.

Detailed description: It is estimated that one-third of the adult population in the United States has blood pressure values that are classified as prehypertension. This slight elevation in blood pressure has been shown to result in an increased risk for developing hypertension and cardiovascular disease. The Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure (JNC7) recommends lifestyle modifications for individuals classified as prehypertensive. One lifestyle modification suggested by JNC7 is regular physical activity. Aerobic exercise, like moderate-intensity continuous training (MCT), has been shown to improve blood pressure, blood vessel function, and arterial stiffness in those with prehypertension. However, a major barrier to exercise adherence is the time commitment required. High-Intensity Interval Training (HIIT), which requires individuals to work at higher intensities for shorter durations, may offer an alternative training design that would reduce the time commitment. Previous studies have shown HIIT to be equal to or better at improving cardiorespiratory fitness and blood vessel function in multiple populations. Limited information is present on HIIT training in those with prehypertension. In this study, participants will be randomized into one of the two training program designs mentioned above (MCT or HIIT). Both programs will be completed over an 8-week period (3 sessions per week) and each training session will be supervised. Participants will complete testing visits before and after the training program to collect measures of cardiovascular health (exercise capacity, blood pressure, blood vessel function, and blood pressure reactivity). The goal is to compare the effects of the training programs on these measures of cardiovascular health.

Eligibility criteria: Inclusion Criteria:

* Blood Pressure less than 140/90 mmHg
* Sedentary

Exclusion Criteria:

* Known or major signs/symptoms of cardiovascular, pulmonary, renal, or metabolic disease
* Cancer
* Use of antihypertensive medication
* Current tobacco use
* BMI (body mass index) less than 30 kg/m2
* Postmenopausal
* Current pregnancy
* Current hormone replacement therapy
* Participating in regular aerobic exercise at least three times a week for 30 minutes at a moderate intensity for the past 3 months or more
* Not able to regularly exercise for any reason

Primary outcomes:
measure: Blood Pressure
timeFrame: Change from baseline resting blood pressure at 8 weeks
Secondary outcomes:
measure: Peak Aerobic Capacity
timeFrame: Change from baseline VO2peak at 8 weeks
measure: 24-Hour Ambulatory Blood Pressure
timeFrame: Change from baseline 24-hour ambulatory blood pressure at 8 weeks
measure: Pulse Wave Analysis
timeFrame: Change from baseline central blood pressure measures at 8 weeks
measure: Endothelial Function
timeFrame: Change from baseline endothelial function at 8 weeks
measure: Arterial stiffness
timeFrame: Change from baseline pulse wave velocity measures at 8 weeks
measure: Blood Pressure Reactivity
timeFrame: Change from baseline blood pressure reactivity at 8 weeks
Other outcomes:
measure: Perceived Enjoyment of Exercise
timeFrame: Measured after 4 and 8 weeks of training
Locations:
city: Newark
country: United States
facility: Department of Kinesiology and Applied Physiology, University of Delaware
state: Delaware
Study officials:
affiliation: University of Delaware
name: Bryce J Muth, MS
role: PRINCIPAL_INVESTIGATOR
affiliation: University of Delaware
name: David G Edwards, PhD
role: PRINCIPAL_INVESTIGATOR
References: