Clinical trial NCT06239922: Cognitive and Neural Assessment Platform and Localized Norm for Macau Older Adults.
Official title: Establishing Cognitive and Neural Assessment Platform and Localized Norm for Macau Older Adults
Study type: OBSERVATIONAL
Overall status: NOT_YET_RECRUITING
Conditions: Cognition Disorders in Old Age
Cognitive Decline
Cognitive Impairment
Cognitive Dysfunction
Cognitive Change
Aging
Keywords: Macau
cognitive aging
Lead sponsor: University of Macau
Sponsor class: OTHER
First posted: 2024-02-02
Enrollment: 300
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: ECOLOGIC_OR_COMMUNITY
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Adults above 50 years old from the Macau local community.

Brief summary: The current project is dedicated to creating a comprehensive cognitive and neural assessment platform and corresponding norms tailored specifically to the older adults in Macau.

Detailed description: The investigators will establish this assessment platform using a combination of methods, including interviews, surveys, and expert reviews.

Steps include adapting existing assessment methods to the Macau context, developing new cognitive and neural tasks, defining standardized procedures, seeking external expert input, conducting pilot tests, and validation processes, and refining both the platform and its accompanying manual.

Eligibility criteria: Inclusion Criteria:

* Must be a local adult resident of Macau
* Age above 50 years for older adult cohort
* Younger adults individuals above 18 will be included as control comparators

Exclusion Criteria:

* History of neurological injury or disease
* Current use of medications that affect brain function or blood flow
* Contraindications to MRI scanning, such as the presence of an electric/mechanical implant or device (e.g., pacemaker)
* Claustrophobia
* Body weight over 300 lbs due to weight and physical constraints of the scanner (i.e., bore size limited to 55 cm)
* Inability to provide informed consent
* Pregnancy
* Being under the legal age of adulthood (children)
* Incarcerated individuals (prisoners)

Primary outcomes:
measure: Normative Data for the Montreal Cognitive Assessment - Chinese (Hong Kong) version
timeFrame: From February 2024 to January 2026
measure: Normative Data for the Mini-Mental State Examination (MMSE)
timeFrame: From February 2024 to January 2026
measure: Normative Scores for Computerized Neuropsychological Tasks
timeFrame: From February 2024 to January 2026
Secondary outcomes:
measure: Neural Activation Patterns During Cognitive Tasks as Revealed by Functional Magnetic Resonance Imaging (fMRI)
timeFrame: From February 2024 to January 2026
measure: Cerebral Hemodynamics Assessed Through Functional Near-Infrared Spectroscopy (fNIRS)
timeFrame: From February 2024 to January 2026
measure: Electrophysiological Correlates of Cognitive Activity as Measured by Electroencephalography (EEG)
timeFrame: From February 2024 to January 2026
Other outcomes:
Locations:
city: Macao
country: Macau
facility: Centre for Cognitive and Brain Sciences of the University of Macau
state: Macao SAR
Study officials:
affiliation: University of Macau
name: Haoyun ZHANG Assistant Professor, Ph.D
role: PRINCIPAL_INVESTIGATOR
References: