Clinical trial NCT02771639: Early Periprosthetic Joint Infection and Outcome Debridement, Antibiotics and Implant Retention
Official title: Early Periprosthetic Joint Infection and Debridement, Antibiotics and Implant Retention in Arthroplasty for Femoral Neck Fracture
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Femoral Neck Fracture
Infection
Keywords: Hip arthroplasty
periprosthetic joint infection
outcome
Lead sponsor: Sundsvall Hospital
Sponsor class: OTHER
First posted: 2016-05-13
Enrollment: 736
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: RETROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Patients treated with a hip arthroplasty for a displaced femoral neck fracture at Sundsvall hospital, Sweden between 2006 and 2015. All patients were included.

Brief summary: Introduction Periprosthetic joint infection (PJI) is a severe complication to hip arthroplasty for femoral neck fractures (FNF). Debridement, antibiotics and implant retention (DAIR) is recommended in early PJI in association with stable implants. Few studies have evaluated the outcome of DAIR in this fragile population.The purpose of this study was to analyze risk factors for PJI and the short-term outcome of DAIR in FNF patients treated with a hip arthroplasty.

Methods A consecutive series of patients had been treated with either a total hip arthroplasty or a hemi hip arthroplasty for a displaced FNF at our institution. Data were retrospective analysed.


Eligibility criteria: Inclusion Criteria:

* Displaced femoral neck fracture
* Treated with a primary hip arthroplasty

Primary outcomes:
measure: Rate of periprosthetic joint infection
timeFrame: 1 year
Secondary outcomes:
measure: The rate of healed periprosthetic joint infections after treatment with surgical debridement.
timeFrame: 6 months
Other outcomes:
Locations:
Study officials:
affiliation: Umeå University
name: Sebastian Mukka, M.D, Ph.D
role: PRINCIPAL_INVESTIGATOR
References:
citation: Osmon DR, Berbari EF, Berendt AR, Lew D, Zimmerli W, Steckelberg JM, Rao N, Hanssen A, Wilson WR; Infectious Diseases Society of America. Executive summary: diagnosis and management of prosthetic joint infection: clinical practice guidelines by the Infectious Diseases Society of America. Clin Infect Dis. 2013 Jan;56(1):1-10. doi: 10.1093/cid/cis966.
citation: Dale H, Fenstad AM, Hallan G, Havelin LI, Furnes O, Overgaard S, Pedersen AB, Karrholm J, Garellick G, Pulkkinen P, Eskelinen A, Makela K, Engesaeter LB. Increasing risk of prosthetic joint infection after total hip arthroplasty. Acta Orthop. 2012 Oct;83(5):449-58. doi: 10.3109/17453674.2012.733918.
citation: Edwards C, Counsell A, Boulton C, Moran CG. Early infection after hip fracture surgery: risk factors, costs and outcome. J Bone Joint Surg Br. 2008 Jun;90(6):770-7. doi: 10.1302/0301-620X.90B6.20194.
citation: Fisman DN, Reilly DT, Karchmer AW, Goldie SJ. Clinical effectiveness and cost-effectiveness of 2 management strategies for infected total hip arthroplasty in the elderly. Clin Infect Dis. 2001 Feb 1;32(3):419-30. doi: 10.1086/318502. Epub 2001 Jan 26.
citation: Noailles T, Brulefert K, Chalopin A, Longis PM, Gouin F. What are the risk factors for post-operative infection after hip hemiarthroplasty? Systematic review of literature. Int Orthop. 2016 Sep;40(9):1843-8. doi: 10.1007/s00264-015-3033-y. Epub 2015 Nov 27.