Clinical trial NCT06703775: Low Level Laser Versus Neural Mobilization of Brachial Plexus on Shoulder Dysfunction Post Liver Donation
Official title: Low Level Laser Versus Neural Mobilization of Brachial Plexus on Shoulder Dysfunction Post Liver Donation
Study type: INTERVENTIONAL
Overall status: NOT_YET_RECRUITING
Phase: NA
Conditions: Shoulder Pain
Lead sponsor: Cairo University
Sponsor class: OTHER
First posted: 2024-11-25
Enrollment: 66
Sex: ALL
Minimum age (years): 20
Maximum age (years): 50
Standard ages: ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The purpose of the study will be to compare therapeutic effect of low level laser versus neural mobilization techniques on shoulder dysfunction post liver donation.

Detailed description: The need for this study develops from the lack of information in the published studies about the effectiveness of low level laser and neural mobilization of brachial plexus on shoulder dysfunction post liver donation.

Following liver donation and transplantation, shoulder dysfunction and discomfort occur in 20% to 60% of patients.

Low-level laser therapy (LLLT) has been used as a non-pharmacological alternative to treat painful musculoskeletal conditions. It is used in acute, chronic painful and inflammatory affections shows that low energy irradiation from lasers alters cellular processes, producing anti-inflammatory effects and increased collagen turnover.

Neural mobilization (NM) is an intervention aimed at restoring the homeostasis in and around the nervous system, by mobilization of the nervous system itself or the structures that surround the nervous system. Neural mobilization facilitates movement between neural structures and their surroundings (interface) through manual techniques or exercise. Human and animal studies revealed that NM reduces intraneural edema, improves intraneural fluid dispersion, reduces thermal and mechanical hyperalgesia and reverses the increased immune responses.

The present study is designed to investigate the effect of LLLT versus NMT on shoulder dysfunction post liver donation.

Eligibility criteria: Inclusion Criteria:

* Patients are both males and females.
* Their age will range from (20-50) years.
* Patients will suffer from unilateral shoulder pain(Rt shoulder).
* Patients will begin the training program one week post.operative.
* All patients will suffer from moderate to severe pain (VAS score \> 4).
* Patients will be given their informed consent.

Exclusion Criteria:

* Known history of high level Spinal cord injury and malignancy
* Metabolic disease with a neurological component such as diabetes.
* Orthopedic disorders such as fracture or dislocation.
* Musculoskeletal disorders that will impair performance during training and tests.
* Uncontrolled cardiovascular or pulmonary diseases .
* Circulatory disturbances of upper extremity
* Psychiatric illness, severe behavior or cognitive disorders.
* Uncooperative patients.

Primary outcomes:
measure: Arabic version of Shoulder Pain and Disability Index (SPADI)
timeFrame: 4 weeks
Secondary outcomes:
measure: Measurement of shoulder flexion range of motion (ROM)
timeFrame: 4 weeks
measure: Measurement of shoulder abduction range of motion (ROM)
timeFrame: 4 weeks
measure: Measurement of shoulder external rotation range of motion (ROM)
timeFrame: 4 weeks
measure: Measurement of maximum isometric force (MIF) of shoulder abductors
timeFrame: 4 weeks
Other outcomes:
Locations:
city: Giza
country: Egypt
facility: faculty of physical therapy, Cairo University
Study officials:
affiliation: Professor, Cairo university
name: Amal Mohamed Abd El-baky, PhD
role: STUDY_CHAIR
References: