louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT00408824: Investigation of Genetic Risk of Metabolic Syndrome in Company Employee (NGK Study)
Official title: Assessment of Genetic Risk of Metabolic Syndrome in Company Employee and Making New Health Guidance Program (NGK Study)
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Healthy
Metabolic Syndrome X
Hyperlipidemia
Hypertension
Diabetes Mellitus
Keywords: insulin resistance
adipocytokine
Metabolic syndrome
Diabetes
Lead sponsor: Nagoya University
Sponsor class: OTHER
First posted: 2006-12-07
Enrollment: 4000
Sex: ALL
Minimum age (years): 20
Maximum age (years): 65
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: CASE_CONTROL
Time perspective: OTHER

Brief summary: The metabolic syndrome is a highly prevalent disorder, which causes atherosclerotic cardiovascular disease and is closely associated with insulin resistance. The alteration of the secretion of adipocytokines from accumulated visceral adipose tissue in the obese induces insulin resistance. The purpose of this study is to identify gene polymorphisms that confer susceptibility to the metabolic syndrome and to make up a new health guidance program based on genetic risk assessment. About 25% of male employees over 45 years old in a certain company are diagnosed with the metabolic syndrome in medical examination. We, the researchers at Nagoya University, will analyze gene polymorphism and various biomarkers of over 3500 company employees.


Eligibility criteria: Inclusion Criteria:

* Healthy subjects who work for a certain company

Primary outcomes:
Secondary outcomes:
Other outcomes:
Locations:
city: Nagoya
country: Japan
facility: Department of Bio-information Analysis, Research Institute of Environmental Medicine, Nagoya University
state: Aichi
Study officials:
affiliation: Department of Bio-information Analysis, Research Institute of Environmental Medicine, Nagoya University
name: Kenji Yasui, MD, PhD
role: STUDY_CHAIR
References:
citation: Tanimura D, Shibata R, Izawa H, Hirashiki A, Asano H, Murase Y, Miyata S, Nakatochi M, Ouchi N, Ichihara S, Yasui K, Yoshida T, Naruse K, Matsubara T, Yokota M. Relation of a common variant of the adiponectin gene to serum adiponectin concentration and metabolic traits in an aged Japanese population. Eur J Hum Genet. 2011 Mar;19(3):262-9. doi: 10.1038/ejhg.2010.201. Epub 2010 Dec 8.
Clinical trial NCT05485324: The Concept of Pain Treatment in Patients With Gunshot and Mine-explosive Wounds and to Develop an Algorithm for Analgesia at the Stages of Treatment
Official title: TREATMENT OF PAIN IN PATIENTS WITH Gunshot and Mine-explosive Wounds AT THE STAGES OF TREATMENT
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Chronic Pain
Keywords: concept of pain treatment, pain, wounds, stages of treatment
Lead sponsor: Bogomolets National Medical University
Sponsor class: OTHER
First posted: 2022-08-03
Enrollment: 2215
Sex: MALE
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: OTHER
Sampling method: PROBABILITY_SAMPLE
Study population: Data collection was carried out at all stages of treatment: medical and nursing brigade, military mobile hospital, military medical clinical center, during rehabilitation, within 12 months of the injury.

Brief summary: in 82.1% of cases it is not possible to achieve a positive result of pain treatment

Detailed description: The concept of pain treatment in patients with gunshot and mine-explosive injuries and the developed pain relief algorithm at the stages of treatment will have an impact on the results of pain treatment in this category of patients.

Eligibility criteria: Inclusion Criteria:

* the presence of gunshot and mine-explosive injuries

Exclusion Criteria:

* absence of gunshot and mine-explosive injuries

Primary outcomes:
measure: visual analog scale
timeFrame: 12 months
measure: Didier Bouhassiraa DN4
timeFrame: 12 months
measure: The Hospital Anxiety and Depression Scale
timeFrame: 12 months
measure: Chaban Quality of Life Scale
timeFrame: 12 months
measure: Mississippi PTSD scale (military version)
timeFrame: 12 months
Secondary outcomes:
Other outcomes:
Locations:
city: Kyiv
country: Ukraine
facility: Bogomolets National Medical University, Ministry of Health of Ukraine
Study officials:
References:
Clinical trial NCT04460924: ARTiBIOME: Observational Study on the Effect of HIV and ART on Gut Microbiome
Official title: ARTiBIOME: Effect of HIV and ART on Gut Microbiome
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: HIV Infections
Lead sponsor: Fundacion para la Investigacion Biomedica del Hospital Universitario Ramon y Cajal
Sponsor class: OTHER
Collaborators: name: Merck Sharp & Dohme LLC
First posted: 2020-07-08
Enrollment: 120
Sex: MALE
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: CASE_CONTROL
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: We will compare 20 MSM HIV negative patients starting PEP with INSTI with:

* 20 MSM HIV-uninfected and ART naïve (A)
* 20 MSM HIV-infected starting ART (B)
* 20 MSM HIV-infected on ART with \>500 CD4 Tcells ( C )
* 20 MSM HIV-infected on ART with \<350 CD4 Tcells (D) (the study population has been restricted to MSM given the strong influence of sexual orientation on the microbiota composition

Brief summary: Antiretroviral treatment for HIV has allowed patients to have undetectable viral load indefinitely. Despite that, HIV infection has become a chronic inflammatory disease, with increased mortality. This pro-inflammatory state is in part explained by the dysbiosis of intestinal bacterial populations. However, little is known on the impact of the antiretroviral treatment on this population and very few studies have evaluated these alterations.

The aim of this study is to study microbiome on healthy patients and HIV-infected patients exposed to antiretroviral treatment with integrase strand transfer inhibitors.


Eligibility criteria: Inclusion criteria:

* Willing to sign consent form
* Men with an age \>18 years
* Engagement in insertive or receptive anal intercourse with another men

  \*Exclusion criteria:
* Previous history of ART exposure
* Use of antibiotics in the past 3 months
* Previous history of inflammatory bowel disease, autoimmune disease or cirrhosis.

Primary outcomes:
measure: Alpha diversity changes of fecal microbiota composition
timeFrame: Baseline and 1 month, 3 months, 12 months
measure: Beta diversity changes of fecal microbiota composition
timeFrame: Baseline and 1 month, 3 months, 12 months
Secondary outcomes:
Other outcomes:
Locations:
city: Madrid
country: Spain
facility: Hospital Ramón y Cajal and Hospital Clínico San Carlos
Study officials:
References:
Clinical trial NCT03690024: Outcame of Cases With Hemolytic Uremic Syndrome Attending Assiut University Child Hospital
Official title: Outcame of Cases With Hemolytic Uremic Syndrome Attending Assiut University Child Hospital
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Hemolytic Uremic Syndrome of Childhood
Lead sponsor: Assiut University
Sponsor class: OTHER
First posted: 2018-10-01
Enrollment: 50
Sex: ALL
Maximum age (years): 18
Standard ages: CHILD
ADULT
Accepts healthy volunteers: no
Observational model: CASE_ONLY
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Patients attending Assiut University Child hospital

Brief summary: Diarrhea-associated hemolytic uremic syndrome (D+HUS) is defined as a prodrome of enteritis followed by thrombocytopenia (\< 150,000/mm3), microangiopathic hemolytic anemia, and signs of variable degrees of renal damage (increase in serum Cr, proteinuria, and/or hematuria) . Our aim is to detect the most reliable early predictors of poor prognosis to identify children at major risk of bad outcome who could eventually benefit from early specific treatments.

Detailed description: The disease is caused predominantly by Shiga toxin-producing enterohemorrhagic Escherichia coli (STEC) and is one of the most common etiologies of acute kidney injury (AKI) and an important cause of acquired chronic kidney disease in children \[2\]. The incidence of HUC tends to parallel the seasonal fluctuation of E.coli o175 : H7 infection which peaks between June \& September. Nowadays, the incidence increases and is typically observe in infants and children, especially those aged 6 months to 4 years. A complicated disease course is defined as the development of one or more of the following manifestations: neurological dysfunction, severe bowel injury, pancreatitis, hemodynamic instability (symptomatic hypotension, multi-organ failure), cardiac (congestive heart failure, myocarditis, pericarditis, arrhythmia) or pulmonary involvement (pulmonary edema, acute respiratory distress syndrome), hematologic complications (hemorrhage), and death \[1\].

Many laboratory and clinical markers upon admission have been associated to severe forms of the disease, including high initial leukocyte and hematocrit levels, major extrarenal complications, dehydration and recently, the blood urea nitrogen (BUN) to serum creatinine (Cr) ratio \[1\], \[4-6\]. Treatment of D+HUS remains supportive; thus, early identification of high-risk patients can optimize their management \[1-3\].

Eligibility criteria: Inclusion Criteria:

* all patients less than 18 years diagnosed with Hemolytic Uremic Syndrome

Primary outcomes:
measure: Complete remission
timeFrame: 1 year
measure: Death
timeFrame: 1 year
measure: Residual renal affection
timeFrame: 1 year
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
References:
Clinical trial NCT02882724: Changes in Speed, Endurance and Balance in Women Patients With Multiple Sclerosis After 4 & 8 Weeks of Aquatic Exercise Training
Official title: Effect Aquatic Exercise Training on Patients With Multiple Sclerosis
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE1
Conditions: Multiple Sclerosis
Aquatic
Exercise
Lead sponsor: University of Isfahan
Sponsor class: OTHER
First posted: 2016-08-30
Enrollment: 32
Sex: FEMALE
Minimum age (years): 20
Maximum age (years): 50
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: SINGLE_GROUP
Primary purpose: TREATMENT

Brief summary: Background: It has been shown that adults with Multiple sclerosis (MS) have less leg strength than their peers, as well as impaired balance, which has led to an increased prevalence of falls in this population.The purpose of this study was to assess the effects of 8-weeks aquatic exercise training in balance, endurance and speed in women with MS.

Methods: In this semi-experimental study, 32 women with clinically-definite relapsing-remittent MS who were registered through the Isfahan MS association volunteered for this study. They randomly selected an aquatic exercise (n = 17) and control (n = 15) groups. Aquatic exercise group completed a 8-week aquatic exercise training program consisted of three sessions per week, each session lasting 45 to 60 minutes 50 to 75 percent of their maximum heart rate reserve on 20-25 degree centigrade's, whereas the control group was instructed to maintain their current lifestyle. The balance of angry was surveyed with using of Berg analyze, speed and endurance 6 minutes walking test before starting of exercise program and after 4 weeks and at the end of 8 weeks was analyzed. The obtained data's were analyzed using analysis of variance with repeated measures.


Eligibility criteria: Inclusion Criteria:

* All women diagnosis of clinically or laboratory supported MS, a minimum time of two years since the diagnosis was made, no relapse within the 4 weeks preceding baseline, ability to participate in regular exercise sessions.

Exclusion Criteria:

* Patients were excluded from the study if they had a relapse during the intervention period, and had a disease preventing their participation (e.g. cardiovascular, respiratory or skeletal diseases).

Primary outcomes:
measure: Effect of exercise on balance was surveyed with using of Berg analyze
timeFrame: up to 8 weeks
Secondary outcomes:
measure: Effect of exercise on speed was measured by walking test
timeFrame: Up to 8 weeks
measure: Effect of exercise on endurance was measured by walking test
timeFrame: Up to 8 weeks
Other outcomes:
Locations:
Study officials:
References:
citation: Kargarfard M, Shariat A, Ingle L, Cleland JA, Kargarfard M. Randomized Controlled Trial to Examine the Impact of Aquatic Exercise Training on Functional Capacity, Balance, and Perceptions of Fatigue in Female Patients With Multiple Sclerosis. Arch Phys Med Rehabil. 2018 Feb;99(2):234-241. doi: 10.1016/j.apmr.2017.06.015. Epub 2017 Jul 20.
Clinical trial NCT01821924: Role of Stress Cardiac MRI in Predicting Adverse Clinical Events in Patients With Known or Suspected Ischemic Heart Disease
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Coronary Artery Disease
Lead sponsor: Brigham and Women's Hospital
Sponsor class: OTHER
First posted: 2013-04-01
Enrollment: 400
Sex: ALL
Minimum age (years): 21
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: RETROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Patients above the age of 21 who are clinically referred for stress cardiac MRI.

Brief summary: The investigators plan to use retrospective data to assess heart function and structure abnormalities through the use of an approved vasodilating agent for stress cardiac MRI tests. The investigators are interested in how these MRI findings relate to long-term prognosis in people who are at risk for cardiac disease.


Eligibility criteria: Inclusion Criteria:

* Age \>/= 21 years old
* No contraindications for cardiac MRI (by renal function or metallic hazards)

Primary outcomes:
measure: All-cause mortality, MI, heart failure hospitalization or documentation of an LV ejection fraction < 0.40 after index CMR at a follow-up.
timeFrame: 5 years
Secondary outcomes:
Other outcomes:
Locations:
city: Boston
country: United States
facility: Brigham and Women's Hospital
state: Massachusetts
Study officials:
References:
citation: Shah R, Heydari B, Coelho-Filho O, Murthy VL, Abbasi S, Feng JH, Pencina M, Neilan TG, Meadows JL, Francis S, Blankstein R, Steigner M, di Carli M, Jerosch-Herold M, Kwong RY. Stress cardiac magnetic resonance imaging provides effective cardiac risk reclassification in patients with known or suspected stable coronary artery disease. Circulation. 2013 Aug 6;128(6):605-14. doi: 10.1161/CIRCULATIONAHA.113.001430. Epub 2013 Jun 26.
Clinical trial NCT00436124: A Study of Tamiflu (Oseltamivir) Treatment in Laboratory-Confirmed Influenza.
Official title: A Randomized, Open Label Study to Evaluate the Effect of Tamiflu on Viral Shedding and on Serum and Cytoplasmic Inflammatory Cytokine Concentrations in Patients With Laboratory-confirmed Influenza
Study type: INTERVENTIONAL
Overall status: TERMINATED
Phase: PHASE4
Conditions: Influenza
Lead sponsor: Hoffmann-La Roche
Sponsor class: INDUSTRY
First posted: 2007-02-16
Sex: ALL
Minimum age (years): 18
Maximum age (years): 64
Standard ages: ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: This study will evaluate the efficacy and safety of Tamiflu in patients with clinically-diagnosed influenza occurring during an influenza outbreak within the community. Patients will be randomized to receive Tamiflu 75mg bid orally plus support therapy (NSAIDs and antibiotics) or support therapy alone. The anticipated time on study treatment is \<3 months, and the target sample size is \<100 individuals.


Eligibility criteria: Inclusion Criteria:

* adult patients, 18-64 years of age;
* ambulatory;
* influenza-like illness;
* positive rapid assay for detection of influenza antigen.

Exclusion Criteria:

* presentation \>36h after onset of symptoms;
* influenza-like symptoms outside an outbreak based on local surveillance activities;
* influenza vaccination between November 2006 and January 2007;
* receipt of antiviral therapy, systemic steroids or immunosuppressants within 2 weeks prior to study day 1.

Primary outcomes:
measure: Viral shedding; serum and intracellular concentrations of inflammatory cytokines (INFgamma, TNFalpha, IL-6, IL-12).
Secondary outcomes:
measure: Efficacy: Duration of illness, health and functional status, extent and severity of symptoms, incidence of resistant viruses. Safety: AEs.
Other outcomes:
Locations:
city: Genova
country: Italy
Study officials:
affiliation: Hoffmann-La Roche
name: Clinical Trials
role: STUDY_DIRECTOR
References:
Clinical trial NCT04288024: The Learning Effects of Task-priority Strategy on Dual-task Weight Shifting and Brain Plasticity in Patients With Parkinson's Disease
Official title: The Learning Effects of Task-priority Strategy on Dual-task Weight Shifting and Brain Plasticity in Patients With Parkinson's Disease
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Postural and Suprapostural Performance During Dual Tasking in Patients With Parkinson's Disease
Keywords: Parkinson
dual-task training
attention
electroencephalogram (EEG)
Lead sponsor: National Taiwan University Hospital
Sponsor class: OTHER
First posted: 2020-02-27
Enrollment: 28
Sex: ALL
Minimum age (years): 50
Maximum age (years): 85
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: (1) postural and suprapostural performance of a dual task would be differently affected by the strategy of task prioritization and (2) the cortical activation is different according to attentional focus strategies.

Detailed description: These hypothesis would be tested by gait performance, suprapostural accuracy and relative power spectrum of EEG.

Eligibility criteria: Inclusion Criteria:

* 1. modified H-Y stage II-III Parkinson's disease 2. No other diseases 3. Non-demented PD 4. Non-tremor PD

Exclusion Criteria:

* None

Primary outcomes:
measure: EEG relative power in the delta band
timeFrame: 60 minutes
measure: EEG relative power in the theta band
timeFrame: 60 minutes
measure: EEG relative power in the alpha band
timeFrame: 60 minutes
measure: EEG relative power in the beta band
timeFrame: 60 minutes
measure: EEG relative power in the gamma band
timeFrame: 60 minutes
measure: COP trajectory recorded from the force plate
timeFrame: 60 minutes
measure: Angles from inclinometer
timeFrame: 60 minutes
Secondary outcomes:
measure: Gait velocity from GAITRite
timeFrame: 5 minutes
measure: Cadence from GAITRite
timeFrame: 5 minutes
measure: Mean step length from GAITRite
timeFrame: 5 minutes
measure: Step-to-step variability from GAITRite
timeFrame: 5 minutes
Other outcomes:
Locations:
city: Taipei
country: Taiwan
facility: National Taiwan University
Study officials:
References:
Clinical trial NCT03612024: Bernese Next of Kin Survey Following Organ Donation Request
Official title: Next of Kin Survey Following Organ Donation Request - a Single Center Experience
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Organ Donation
Next of Kin
Post Traumatic Stress Disorder
Lead sponsor: Insel Gruppe AG, University Hospital Bern
Sponsor class: OTHER
First posted: 2018-08-02
Enrollment: 117
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Next of kin involved in request for organ donation. Single center study. The request for organ donation must have passed 6 to 18 months ago

Brief summary: 6 to 18 months after organ donation request a next of kin survey using a standardized questionnaire was conducted.


Eligibility criteria: Inclusion Criteria:

Next of kin involved in request for organ donation

Primary outcomes:
measure: factors influencing approval/rejection of an organ donation
timeFrame: 6 to 18 months pre questionnaire
measure: factors with influence on mourning porcess
timeFrame: 6 to 18 months past request
Secondary outcomes:
Other outcomes:
Locations:
city: Bern
country: Switzerland
facility: Department for Intensive Care Medicine
Study officials:
affiliation: department of critical care medicine, inselspital, university hospital, bern, university of bern
name: Andreas Bloch, MD
role: PRINCIPAL_INVESTIGATOR
References:
citation: Nebiker M, Bloch A, Fedakar P, Christen L, Hurni A, Carre D, Cluzet S, Eckert P, Schefold JC. Organ donation in the ICU - a survey on next of kin response in two Swiss academic centres. Swiss Med Wkly. 2021 Jun 23;151:w20515. doi: 10.4414/smw.2021.20515. eCollection 2021 Jun 21.
Clinical trial NCT04184024: A Comparison of the Effectiveness of Massage and Kinesio Taping in Neck Pain
Official title: A Comparison of the Effectiveness of Massage and Kinesio Taping on Pain, Range of Motion, Disability and Quality of Life in Patients With Chronic Neck Pain
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Neck Pain
Keywords: neck pain, massage, kinesio tape,
Lead sponsor: Ataturk Training and Research Hospital
Sponsor class: OTHER
First posted: 2019-12-03
Enrollment: 42
Sex: ALL
Minimum age (years): 18
Maximum age (years): 65
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: This study aimed to compare the effectiveness of massage and Kinesio taping on pain, range of motion, disability and quality of life in patients with chronic neck pain.

Detailed description: Neck pain is a common condition, affecting 30% to 50% of the general population, and is most prevalent in middle age.33 It is usually accompanied by a substantial effect on daily life, resulting in an extensive use of health care resources.

Several physical therapy applications such as massage therapy, kinesio taping, thermal and electrophysiological agents, hydrotherapy/spa therapy, and therapeutic exercises especially neck stabilization exercise are used to manage FM. Both massage therapy and kinesio taping have a favorable effect on clinical symptoms. However, it is not clear which method is more effective. Therefore, this study aimed to compare the effectiveness of massage and Kinesio taping on pain, range of motion, disability and quality of life in patients with chronic neck pain.

Eligibility criteria: Inclusion Criteria:

* 18 to 65 years of age,
* having generalized neck pain for more than 3 months,
* being volunteer

Exclusion Criteria:

* pregnancy,
* inflammatory rheumatologic diseases,
* malignity,
* structural deformity,
* previous surgery related to the cervical spine,
* cervical spinal stenosis,
* being allergic to Kinesio tape
* severe psychological disorder,
* any intervention that included exercise or physical therapy in the last 3 months.

Primary outcomes:
measure: Pain Level (Visual Analog Scale)
timeFrame: change from baseline at 4 weeks
Secondary outcomes:
measure: Turkish of the Short Form-36
timeFrame: change from baseline at 4 weeks
measure: Turkish version of Neck Disability Index
timeFrame: change from baseline at 4 weeks
measure: Range of Motion
timeFrame: change from baseline at 4 weeks
Other outcomes:
Locations:
city: Ankara
country: Turkey
facility: Ankara Yildirim Beyazit University
Study officials:
affiliation: Ankara Yildirim Beyazıt University
name: seyda toprak celenay
role: PRINCIPAL_INVESTIGATOR
References: