Clinical trial NCT05546086: BeijngFH Health Cohort Study
Official title: Risk Prediction System for Metabolic Associated Fatty Liver Disease, a Community-based Cohort Study
Study type: OBSERVATIONAL
Overall status: RECRUITING
Conditions: Non-Alcoholic Fatty Liver Disease
Keywords: Non-Alcoholic Fatty Liver Disease
Cohort Studies
Risk Factors
Lead sponsor: Beijing Friendship Hospital
Sponsor class: OTHER
Collaborators: name: Chinese Academy of Medical Sciences
First posted: 2022-09-19
Enrollment: 8103
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: The present community-based cohort study enrolls subjects who take health physical examinations at the sub-center outpatient department, Beijing Friendship Hospital from April 2022.

Brief summary: Metabolic associated fatty liver disease(MEFLD) is a major chronic liver disease that can lead to various adverse events, such as liver cancer, cardiovascular disease, and chronic kidney disease. The present community-based cohort study enrolls subjects who take health physical examinations at the sub-center outpatient department, Beijing Friendship Hospital. Investigators collect their baseline information, including demographic data, clinical history, physical examination, laboratory results, imageological examination, and so on. Follow-up surveys are conducted annually and the information collected is the same as the baseline. The outcome information, including cardiovascular disease, malignancy, liver cirrhosis, liver decompensation, liver transplantation, and all-cause mortality, are obtained by linking to the hospital discharge database and death registration system of Beijing. The primary aim of the study is to build a risk-stratified evaluation system for MAFLD through the cohort.

Detailed description: The present community-based cohort study enrolls subjects who take physical health examinations at the sub-center outpatient department, Beijing Friendship Hospital. After signing the informed consent, Their previous health physical examination results, which were recorded in the Hospital Information System (HIS) are collected retrospectively. Then, Investigators collect their baseline information, including demographic data, clinical history, physical examination, laboratory results, image logical examination, and so on. Additionally, follow-up surveys will be conducted annually and the information collected is the same as the baseline. The outcome information, including cardiovascular disease, malignancy, liver cirrhosis, liver decompensation, liver transplantation, and all-cause mortality, is obtained from the hospital discharge database and death registration system in Beijing. The study's primary aim is to build a risk-stratified evaluation system for MAFLD through a community population cohort with long-term stable follow-up.

Eligibility criteria: Inclusion Criteria:

* Aged 18 years or older
* Permanent residents in Beijing
* Signing informed consent

Exclusion Criteria:

* No

Primary outcomes:
measure: Cardiovascular disease
timeFrame: 1 to 10 years
Secondary outcomes:
measure: Malignancy
timeFrame: 1 to 10 years
measure: Liver cirrhosis
timeFrame: 1 to 10 years
measure: Liver decompensation
timeFrame: 1 to 10 years
measure: Liver transplantation
timeFrame: 1 to 10 years
measure: All-cause mortality
timeFrame: 1 to 10 years
Other outcomes:
Locations:
city: Beijing
country: China
facility: Beijing Friendship Hospital, Capital Medical University
Study officials:
References: