louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT05059366: Manual Ventilation Efficacy With MVG Device
Official title: Improvement of Manual Ventilation Efficacy With Ventilation Grip Device: A Manikin Study
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Ventilator Lung
Keywords: Manual Ventilation Grip Device
Lead sponsor: University of Miami
Sponsor class: OTHER
First posted: 2021-09-28
Enrollment: 32
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: CROSSOVER
Intervention model description: The study is a repeated-measures cross over design.
Primary purpose: SUPPORTIVE_CARE

Brief summary: The purpose of this research is to investigate the efficacy of the newly designed ventilation grip device (MVG device).


Eligibility criteria: Inclusion Criteria:

1. Current medical students, Post Graduate Year 1 (PGY1) residents or residents from other specialties with no prior experience in hand mask ventilation techniques or anesthesiology residents and attendings with at least 2 or more years of clinical experience

Exclusion Criteria:

1. Refusal to participate in the study.
2. Medical students with prior experience in hand mask ventilation techniques (i.e. experiences in previous careers such as nursing or Emergency Medical Technician (EMT) professions)
3. Any physical inability to adequately perform ventilation

Primary outcomes:
measure: Tidal Volume
timeFrame: Day 1
Secondary outcomes:
measure: Fatigue as Measured by NASA-TLX Questionnaire
timeFrame: Day 1
measure: Fatigue as Measured by SOFI Questionnaire
timeFrame: Day 1
Other outcomes:
Locations:
city: Miami
country: United States
facility: University of Miami
state: Florida
Study officials:
affiliation: University of Miami
name: Alecia Stein
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT00870766: Computer Tomography (CT) Trial of Acute Abdomen
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Acute Abdomen
Lead sponsor: Kuopio University Hospital
Sponsor class: OTHER
First posted: 2009-03-27
Enrollment: 250
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: DIAGNOSTIC

Brief summary: The purpose of this study is to determine the impact of routinely performed early CT scanning in terms of diagnostic accuracy, patient management and cost-effectiveness compared to current imaging practice in patients suffering from acute abdomen.


Eligibility criteria: Inclusion Criteria:

* age \> 18
* abdominal pain \> 2h and \< 7 days

Exclusion Criteria:

* pregnancy
* acute abdominal trauma
* allergy to iodinated contrast media
* severe renal insufficiency
* metformin medication combined with elevated plasma creatinin level
* lack of cooperation (if informed consent is not possible)
* abdominal pain combined with bleeding shock

Primary outcomes:
measure: Diagnostic accuracy
timeFrame: at discharge and/or 2-3 mo follow-up
Secondary outcomes:
Other outcomes:
Locations:
city: Kuopio
country: Finland
facility: Kuopio University Hospital
Study officials:
References:
Clinical trial NCT06575166: The Impact of Abdominal Wall Reconstruction on Abdominal Wall Tension and Intra-Abdominal Pressure
Official title: The Impact of Abdominal Wall Reconstruction on Abdominal Wall Tension and Intra-Abdominal Pressure
Study type: OBSERVATIONAL
Overall status: RECRUITING
Conditions: Ventral Hernia
Incisional Hernia
Parastomal Hernia
Lead sponsor: The Cleveland Clinic
Sponsor class: OTHER
First posted: 2024-08-28
Enrollment: 25
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: Adult patients with an incisional or parastomal hernia with a \>20 cm fascial defect on pre-operative imaging who undergo an anticipated open bilateral transversus abdominis release with retro-muscular synthetic mesh placement will be included. The investigators anticipate that patients with very large defects will experience the greatest changes in abdominal wall tension and intra-abdominal pressure.

Brief summary: This is a prospective cohort study. Patients have an incisional or parastomal hernia with \>20 cm fascial defect on pre-operative imaging who will undergo an anticipated open bilateral transversus abdominis release with retromuscular synthetic mesh will have their abdominal wall tension measured using a tension scale and their intra-abdominal pressure measured using a urinary catheter containing pressure sensors. The investigators aim to quantify the changes, as well as explore and describe the physiologic shifts that may be associated with these changes.


Eligibility criteria: Inclusion Criteria:

* Patients ≥ 18 years of age
* Incisional or parastomal hernia with \>20 cm fascial defect on pre-operative imaging
* Anticipated open bilateral transversus abdominis release with retro-muscular synthetic mesh placement

Exclusion Criteria:

* Pregnant patients
* Require a Legally Authorized Representative (LAR) to sign the informed consent form

Primary outcomes:
measure: Correlation between intra-abdominal pressure (mmHg) and rate of post-operative complications
timeFrame: 1 year
Secondary outcomes:
measure: Correlation between intra-abdominal pressure (mmHg) to abdominal wall tension (lbs)
timeFrame: 1 year
measure: Correlation between abdominal wall tension (lbs) and intra-abdominal pressure (mmHg) to hernia defect size (cm)
timeFrame: 1 year
measure: Correlation between abdominal wall tension (lbs) and intra-abdominal pressure (mmHg) to airway pressure (cmH2O)
timeFrame: 1 year
measure: Temporal changes in renal function (serum Creatinine)
timeFrame: 1 year
Other outcomes:
Locations:
city: Cleveland
country: United States
facility: Cleveland Clinic Foundation
state: Ohio
Study officials:
affiliation: The Cleveland Clinic
name: Benjamin T Miller, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT03583866: Adiposity and Endothelin Receptor Function
Official title: Adiposity and Endothelin Receptor Function
Study type: INTERVENTIONAL
Overall status: ACTIVE_NOT_RECRUITING
Phase: EARLY_PHASE1
Conditions: Hypertension
Keywords: blood pressure
microdialysis
Lead sponsor: Augusta University
Sponsor class: OTHER
Collaborators: name: National Heart, Lung, and Blood Institute (NHLBI)
First posted: 2018-07-12
Enrollment: 25
Sex: ALL
Minimum age (years): 18
Maximum age (years): 40
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: CROSSOVER
Primary purpose: TREATMENT

Brief summary: Elevated levels of ET-1 have been implicated in cardiovascular disease and some forms of hypertension. Due to the strong, positive correlation between obesity and hypertension, the present study will explore the contribution of adiposity in ETB receptor function and aim to elucidate if ETB receptor dysfunction is a major contributor to hypertension in obesity.

Detailed description: The proposed study is designed to investigate the influence of adiposity on ETB receptor function and subsequent vascular responses. The combination of ET-1, ET-3, and the respective ETA and ETB receptor antagonists will be used to provide insight into the mechanisms of ETB receptor dysfunction in the presence of adiposity. Previous studies have revealed elevations in circulating ET-1 in obese individuals; therefore, we predict that obese subjects will exhibit 1) ETB receptor dysfuncton compared to lean subjects and 2) an improvement in ETB receptor dysfunction following treatment with Candesartan.

Eligibility criteria: Inclusion Criteria:

• If you are an adult between the ages of 18-40 year old

Exclusion Criteria:

* Evidence of cardiovascular, pulmonary, renal, hepatic, cerebral, or metabolic disease
* Evidence of pregnancy
* Using medications that affect vascular tone (i.e., nitrates, etc.)
* Use of any anticoagulants (i.e. aspirin)
* Anemia
* If you are postmenopausal
* If you have uncontrolled hypertension (treated resting SBP \>140 mm Hg or DBP \>90 mm Hg)

Primary outcomes:
measure: Percentage Change in Flow-Mediated Dilation (FMD)
timeFrame: pre-treatment Baseline and 7 days post-treatment
Secondary outcomes:
Other outcomes:
Locations:
city: Augusta
country: United States
facility: Georgia Prevention Institute/ Laboratory of Integrative and Exercise Physiology
state: Georgia
Study officials:
affiliation: Augusta University
name: Ryan Harris, PHD, CES
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT06884566: Effect of Acute Supplementation (taurine) on Maximal Strength and Anaerobic Power
Official title: Effect of Acute Supplementation (taurine) on Maximal Strength and Anaerobic Power
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Taurine
Keywords: Taurine
Power
Strenght
Exercise
Lead sponsor: University of Central Lancashire Cyprus
Sponsor class: OTHER
First posted: 2025-03-19
Enrollment: 17
Sex: ALL
Minimum age (years): 18
Maximum age (years): 40
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: CROSSOVER
Primary purpose: BASIC_SCIENCE

Brief summary: This crossover-design study examines the acute effect of taurine on trained individuals aged 18-40 on strength and power outputs.

Detailed description: The purpose of this study is to further investigate any potential ergogenic effects offered by taurine, under specific conditions, namely that of acute supplementation, as opposed to the chronic supplementation protocols of many popular ergogenic aids, such as creatine and beta alanine. Exercise modes investigated include maximal isometric strength, maximal instantaneous power generation, and sustained maximal anaerobic power output, investigated via grip strength, vertical jump height, and the Wingate test, respectively.

Eligibility criteria: Inclusion Criteria:

* participants 18 - 40 years of age
* physically active or recreationally active with consistent training more than 3 times per week for at least 6 months
* non-smokers

Exclusion Criteria:

* cardiovascular, respiratory or metabolic diseases
* any musculoskeletal injury in the last six months
* taking taurine and/or creatine supplementation in the past three months

Primary outcomes:
measure: Maximal Isometric strength in kilograms assessed via handgrip test
timeFrame: Day 1
measure: Relative Isometric strength in kilograms assessed via handgrip test
timeFrame: Day 1
measure: Maximal Instantaneous power generation in W/kg assessed via vertical jump height test.
timeFrame: Day 1
measure: Average Instantaneous power generation in W/kg assessed via vertical jump height test.
timeFrame: Day 1
measure: Peak power in Watts assessed via the Wingate Anaerobic test
timeFrame: Day 1
measure: Maximal Isometric strength in kilograms assessed via handgrip test
timeFrame: After 48 hours
measure: Relative Isometric strength in kilograms assessed via handgrip test
timeFrame: After 48 hours
measure: Maximal Instantaneous power generation in W/kg assessed via vertical jump height test.
timeFrame: After 48 hours
measure: Average Instantaneous power generation in W/kg assessed via vertical jump height test.
timeFrame: After 48 hours
measure: Peak power in Watts assessed via the Wingate Anaerobic test
timeFrame: After 48 hours
Secondary outcomes:
Other outcomes:
Locations:
city: Larnaca
country: Cyprus
facility: University of Central Lancashire Cyprus
state: Pyla
Study officials:
affiliation: https://www.uclancyprus.ac.cy/
name: Efstathios Christodoulides, PhD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT03907566: The Turkish Oropharyngeal Dysphagia Screening Test for Patients and Professionals
Official title: The Turkish Version of the Oropharyngeal Dysphagia Screening Test for Patients and Professionals
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Swallowing Disorder
Lead sponsor: Hacettepe University
Sponsor class: OTHER
First posted: 2019-04-09
Enrollment: 100
Sex: MALE
Minimum age (years): 20
Maximum age (years): 60
Standard ages: ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Adult patients with swallowing concerns

Brief summary: The purpose of this study is to test the reliability and validity of the The Turkish Oropharyngeal Dysphagia Screening Test for Patients and Professionals among adult patients with swallowing disorders.

Detailed description: The purpose of this study is to test the reliability and validity of the The Turkish Oropharyngeal Dysphagia Screening Test for Patients and Professionals among adult patients with swallowing disorders.The internal consistency, test-retest reliability, and criterion validity of the instrument will be investigated. The internal consistency will be assessed using Cronbach's alpha. Intraclass correlation coefficient (ICC) value with 95 % confidence intervals will be calculated for test-retest reliability. The criterion validity of the scale will be determined by assessing the correlation between the The Turkish Oropharyngeal Dysphagia Screening Test for Patients and Professionals and Turkish Eating Assessment Tool.

Eligibility criteria: Inclusion Criteria:

* Willing to participate
* Having swallowing problems

Exclusion Criteria:

* Being under the age of 20 years, and above the age of 60 years
* Not willing to participate
* No swallowing problems

Primary outcomes:
measure: The Turkish Oropharyngeal Dysphagia Screening Test for Patients and Professionals
timeFrame: 3 months
Secondary outcomes:
measure: The Turkish version of the Eating Assessment Tool-10
timeFrame: 3 months
Other outcomes:
Locations:
city: Ankara
country: Turkey
facility: Hacetttepe University
Study officials:
affiliation: Hacettepe University
name: SELEN SEREL ARSLAN
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT00973466: Prevalence of Sexually Transmitted Infections (STIs) in HIV-infected Patients
Official title: Prevalence of Asymptomatic and Symptomatic Infection of N. Gonorrheae and C. Trachomatis and Seroprevalence of HSV Typ 2 and Sexual Health Seeking Behaviour in People With HIV Infection in Bern
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: HIV Infections
Neisseria Gonorrhoeae
Chlamydia Trachomatis
Herpes Simplex
Keywords: HIV-infection
Neisseria gonorrhea
Chlamydia trachomatis
Herpes simplex virus
prevalence
Lead sponsor: Insel Gruppe AG, University Hospital Bern
Sponsor class: OTHER
Collaborators: name: Pfizer
name: Merck Sharp & Dohme LLC
First posted: 2009-09-09
Enrollment: 300
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: All consecutive HIV-infected patients attending the Clinic for Infectious Diseases at Bern University Hospital will be asked to participate in the study if they were sexually active during the last 12 months

Brief summary: There has been an increase in incidence in sexually transmitted infections in HIV infected patients in the last years. In this study the investigators will prospectively evaluate the prevalence of symptomatic and asymptomatic infections with N. gonorrhea and Ch. trachomatis as well as the seroprevalence of Herpes simplex Type 2 infection in HIV-infected patients attending the clinic for infectious diseases at the Berne University Hospital. In addition, participants will be asked to fill out a questionnaire on sexual behaviour and sexual health.

Study hypothesis: STI prevalence is high in certain risk-groups to justify screening in regular intervals.


Eligibility criteria: Inclusion Criteria:

* HIV-infection
* Attending the Clinic for Infectious Diseases from May 09 to November 09
* Sexually active during the last 12 months
* Written informed consent

Exclusion Criteria:

* None

Primary outcomes:
measure: Prevalence of infection with C.trachomatis, N. gonorrhea and Seroprevalence of HSV 2 infection
timeFrame: 6 months
Secondary outcomes:
Other outcomes:
Locations:
city: Bern
country: Switzerland
facility: Clinic for Infectious Diseases, Berne University Hospital
Study officials:
affiliation: University Hospital Berne
name: Hansjakob Furrer, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT07014566: Effectiveness of Digital Physiotherapy in the Short and Long-Term Management of Lower Extremity Lymphedema
Official title: Effectiveness of Digital Physiotherapy in the Short and Long-Term Management of Lower Extremity Lymphedema
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Lower Extremity Lymphedema
Keywords: Lower extremity lymphedema
Digital physiotherapy
Combined decongestive therapy
Lead sponsor: Bezmialem Vakif University
Sponsor class: OTHER
First posted: 2025-06-11
Enrollment: 82
Sex: FEMALE
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: TREATMENT

Brief summary: This study investigated the short- and long-term effects of digital physiotherapy in patients with unilateral and bilateral lower extremity lymphedema. Limb volume and quality of life were assessed at baseline, post-treatment, and 12-week follow-up.

Detailed description: This study evaluated the feasibility and effectiveness of a digital physiotherapy program based on combined decongestive therapy in patients with lower extremity lymphedema. After an initial face-to-face training session on self-bandaging, self-manual lymphatic drainage, breathing exercises, and skin care, patients followed a 4-week digital physiotherapy program with remote supervision. Compression stockings were used during the maintenance phase. Limb volume was measured using circumference method. Quality of life was assessed with the Lymphoedema functioning, disability and health questionnaire questionnaire. Assessments were repeated post-treatment and at 12-week follow-up.

Eligibility criteria: Inclusion Criteria:

* Diagnosed with unilateral lower extremity lymphedema (either primary or secondary)
* Patients aged 18 years or older

Exclusion Criteria:

* Presence of metastatic disease
* History of coronary heart disease, pulmonary disease, or acute infection of any cause
* Presence of peripheral neuropathy

Primary outcomes:
measure: Change in Limb Volume
timeFrame: At baseline, at week 4 (end of treatment), and at week 12 (follow-up)
Secondary outcomes:
measure: Change in Quality of Life
timeFrame: At baseline, at week 4 (end of treatment), and at week 12 (follow-up)
Other outcomes:
Locations:
city: İstanbul
country: Turkey
facility: Bezmialem Vakıf University Hospital
Study officials:
References:
citation: Wu X, Liu Y, Zhu D, Wang F, Ji J, Yan H. Early prevention of complex decongestive therapy and rehabilitation exercise for prevention of lower extremity lymphedema after operation of gynecologic cancer. Asian J Surg. 2021 Jan;44(1):111-115. doi: 10.1016/j.asjsur.2020.03.022. Epub 2020 May 10.
Clinical trial NCT00326066: A Study of the iStent in Combo With Cataract Surgery in Newly Diagnosed Open Angle Glaucoma or OH Patients.
Official title: A Study of the Trabecular Micro-bypass Stent in Combination With Cataract Surgery in Subjects With Newly Diagnosed Open Angle Glaucoma and Subjects Diagnosed With Ocular Hypertension
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Open-Angle Glaucoma
Keywords: Open angle
Glaucoma
Surgery
Cataract
Lead sponsor: Glaukos Corporation
Sponsor class: INDUSTRY
First posted: 2006-05-16
Enrollment: 47
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The purpose of this study is to evaluate the safety and efficacy of the iStent trabecular micro-bypass stent in reducing intraocular pressure (IOP) in subjects with newly diagnosed open-angle glaucoma and subjects diagnosed with Ocular hypertension.

Detailed description: The study will compare the reduction in IOP of those subjects implanted with two Glaukos micro-stents with the reduction in IOP for patients receiving only primary medical therapy (Xalatan - Latanoprost) or cataract surgery alone. Both groups will undergo routine cataract surgery.

Eligibility criteria: Inclusion Criteria:

* Newly diagnosed with open-angle glaucoma (OAG) or Ocular Hypertension with subjects not yet taking any glaucoma medications or recently diagnosed with mild open-angle glaucoma and are currently being treated with up to 2 glaucoma medications.
* All subjects must need cataract surgery.

Exclusion Criteria:

* Angle closure glaucoma
* Secondary glaucomas except pseudoexfoliative and pigmentary; no neovascular, uveitic or angle recession glaucoma
* Prior glaucoma procedures (eg trabeculectomy, viscocanalostomy, ALT, SLT, shunt implant, collagen implant, cyclo destructive procedures etc)
* Fellow eye already enrolled

Primary outcomes:
measure: Efficacy
timeFrame: 24 months
Secondary outcomes:
Other outcomes:
Locations:
city: Vienna
country: Austria
facility: Vienna Medical Hospital
city: Mainz
country: Germany
facility: Mainz University
city: Munich
country: Germany
facility: Augenklinik der Technischen Universitat
city: Wurzburg
country: Germany
facility: Universitats- Augenklinik
city: Amsterdam
country: Netherlands
facility: The Netherlands Ophthalmic Research Institute
city: Rotterdam
country: Netherlands
facility: Ophthalmic Clinic
city: Madrid
country: Spain
facility: Clinico San Carlos
city: Zaragoza
country: Spain
facility: Instituto Oftalmológico de Aragón
city: Istanbul
country: Turkey
facility: Beyoglu Eye Research and Education Hospital
Study officials:
affiliation: Glaukos Corporation
name: Head of Clinical Affairs
role: STUDY_DIRECTOR
References:
citation: Fernandez-Barrientos Y, Garcia-Feijoo J, Martinez-de-la-Casa JM, Pablo LE, Fernandez-Perez C, Garcia Sanchez J. Fluorophotometric study of the effect of the glaukos trabecular microbypass stent on aqueous humor dynamics. Invest Ophthalmol Vis Sci. 2010 Jul;51(7):3327-32. doi: 10.1167/iovs.09-3972. Epub 2010 Mar 5.