louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT01618058: Observational Study of HIV Infection in Participants of Seroconvert During Dapivirine Vaginal Ring Trials
Official title: A Long-Term Observational Cohort Study of HIV Infection in Participants Who Seroconvert After Enrolment in Dapivirine Vaginal Ring Trials
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: HIV Infections
Keywords: HIV Infections
Anti-HIV Agents
HIV-1
Lead sponsor: International Partnership for Microbicides, Inc.
Sponsor class: INDUSTRY
First posted: 2012-06-13
Enrollment: 151
Sex: FEMALE
Minimum age (years): 18
Maximum age (years): 45
Standard ages: ADULT
Accepts healthy volunteers: no
Observational model: CASE_CONTROL
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Both microbicide and placebo recipients in IPM 027 who have become HIV infected (HIV-1 or HIV-2) while participating in IPM 027 will be offered enrolment in IPM 007 at the exit visit of IPM 027, i.e. approximately 6 weeks after identification of HIV seroconversion.

This study includes all active IPM clinical research centres that enrol participants for IPM microbicide trials.

Brief summary: The purpose of this trial is to determine if exposure to ARV-containing investigational products in IPM clinical trials will impact the natural history of HIV infection as measured by the virologic, immunologic and clinical outcomes of participants who become HIV-positive during the IPM 027 trial.


Eligibility criteria: Inclusion Criteria:

* Recent HIV seroconversion during participation in IPM 027, according to the HIV testing algorithm of that trial
* Ability and willingness to provide informed consent
* Willingness to give the research centre permission to share information with the primary health care provider (PHCP), and willingness to sign approved site-specific documentation to facilitate such sharing.

Exclusion Criteria:

* Any condition that, in the opinion of the Investigator, would preclude provision of informed consent, make participation in the study unsafe, complicate interpretation of study outcome data, or otherwise interfere with achieving the study objectives.

Primary outcomes:
measure: To identify HIV drug resistant mutations following recent seroconversion in plasma and vaginal secretions and change in resistant mutations over time in participants previously exposed to an ARV-based microbicide or a placebo.
timeFrame: 12 months
Secondary outcomes:
Other outcomes:
Locations:
city: Kiyovu
country: Rwanda
facility: Project Ubuzima
state: Kigali
city: Ladysmith
country: South Africa
facility: Qhakaza Mbokodo
state: Kwazulu Natal
city: Pinetown
country: South Africa
facility: Prevention for HIV and AIDS Project (PHIVA)
state: Kwazulu Natal
city: Brits
country: South Africa
facility: Madibeng Centre for Research (MCR)
city: Plessislaer
country: South Africa
facility: Maternal, Adolescent and Child Health (MatCH)
Study officials:
affiliation: Desmond Tutu HIV Centre
name: Linda-Gail Bekker
role: STUDY_CHAIR
References:
Clinical trial NCT06756958: Reliability and Validity of Pittsburgh Rehabilitation Participation Scale During Robot Therapy
Official title: Reliability and Validity of Pittsburgh Rehabilitation Participation Scale During Robot Therapy Among Patients with Stroke
Study type: OBSERVATIONAL
Overall status: TERMINATED
Conditions: Stroke
Keywords: participation
robot
scale
rehabilitation
Lead sponsor: National Rehabilitation Center, Seoul, Korea
Sponsor class: OTHER_GOV
First posted: 2025-01-03
Enrollment: 46
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Those who participated the tethered-robot assisted gait training, had the history of brain lesion and adimitted in the rehabilitation center.

Those who gave the informed consent about this study.

Brief summary: Reliability and validity of Pittsburgh Rehabilitation Participation Scale during robot therapy among patients with stroke


Eligibility criteria: Inclusion Criteria:

* patients with stroke or traumatic brain injury
* inpatient in rehabilitation center

Exclusion Criteria:

* brain tumor
* spinal cord injury

Primary outcomes:
measure: Pittsburgh Rehabilitation Participation Scale
timeFrame: through study completion, an average of 3 year
Secondary outcomes:
measure: modified Barthel Index
timeFrame: baseline and 4 weeks from baseline
measure: 10m walk
timeFrame: baseline and 4 weeks from baseline
measure: Borg scale
timeFrame: baseline and 4 weeks from baseline
measure: 6 min walk
timeFrame: baseline and 4 weeks from baseline
measure: motricity index
timeFrame: baseline and 4 weeks from baseline
measure: Berg balance scale
timeFrame: baseline and 4 weeks from baseline
measure: Trunk impairment scale
timeFrame: baseline and 4 weeks from baseline
measure: Function in sitting test
timeFrame: baseline and 4 weeks from baseline
measure: Modified Rankin Scale for Neurologic Disability
timeFrame: baseline and 4 weeks from baseline
measure: Functional Ambulatory Category
timeFrame: baseline and 4 weeks from baseline
measure: Timed Timed Up and Go test
timeFrame: baseline and 4 weeks from baseline
measure: Manual Muscle Testing
timeFrame: baseline and 4 weeks from baseline
measure: modified Ashworth scale
timeFrame: baseline and 4 weeks from baseline
measure: National Institutes of Health Stroke Scale
timeFrame: baseline and 4 weeks from baseline
Other outcomes:
Locations:
city: Seoul
country: Korea, Republic of
facility: National Rehabilitation Center
city: Seoul
country: Korea, Republic of
facility: Jung Hwan Kim
Study officials:
References:
Clinical trial NCT00184158: Treatment for Cubital Tunnel Syndrome
Official title: Cubital Tunnel Treatment, Evaluation of Conservative and Operative Alternatives
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Cubital Tunnel Syndrome
Keywords: Cubital tunnel
treatment
nerve compression
Lead sponsor: Norwegian University of Science and Technology
Sponsor class: OTHER
First posted: 2005-09-16
Enrollment: 81
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The researchers want to find out the best treatment for cubital tunnel. The researchers establish the degree of nerve compression and then the patients are randomised to different treatment alternatives, ranging from conservative to operative treatments.

The study is performed at 5 different hospitals in Norway.


Eligibility criteria: Inclusion Criteria:

* Patients with cubital tunnel syndrome

Exclusion Criteria:

* Rheumatoid arthritis (RA)
* Osteoarthrosis
* Varus or valgus deformities at elbow

Primary outcomes:
measure: pain
Secondary outcomes:
measure: electroneurography (ENG
measure: paresthesia
measure: weakness
measure: patient satisfaction
Other outcomes:
Locations:
city: Trondheim
country: Norway
facility: St Olavs Hospital
Study officials:
affiliation: National Taiwan Normal University
name: Vilhjalmur Finsen, Prof
role: STUDY_DIRECTOR
References:
Clinical trial NCT04817358: Genetic Influences on Dental Maturation: A Twin Study
Official title: Genetic Influences on Dental Maturation: A Twin Study
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Dental Age Estimation Methods
Lead sponsor: Suleyman Demirel University
Sponsor class: OTHER
First posted: 2021-03-26
Enrollment: 171
Sex: ALL
Minimum age (years): 5
Maximum age (years): 13
Standard ages: CHILD
Accepts healthy volunteers: yes
Observational model: CASE_ONLY
Time perspective: CROSS_SECTIONAL
Sampling method: NON_PROBABILITY_SAMPLE
Study population: A total of MZ and DZ pairs between the ages of 5.0 and 12.9 who attended to the Department of Pedodontics at Suleyman Demirel University and underwent radiological examination for any dental reason during the dental treatment period from January 2018 to January 2021

Brief summary: The genetics has been shown as one of the most important factor influencing the growth and development of the dentofacial complex. Dental development, one of the most reliable indicators of chronological age (CA), has been believed to be fundamentally influenced by genetics rather than environmental factors. As twins share genetic variation (100% for monozygotic and 50% for dizygotic twins) and were subjected to the similar environmental factors, the twin studies have been presented useful and effective method to researchers for investigating the influence of heredity on dental development and observing the similarities and differences among twin pairs.

Evaluation of dental development is among the most commonly used and reliable method for dental age determination using the morphological parameters of teeth on dental radiographs. Dental maturity, defined as a dental age (DA), is very important in forensic anthropology to identify cases and in dentistry for planning pedodontic and orthodontic treatment, and also determining a child's growth and developmental status.

There are many dental age estimation methods which are mostly based on the morphological evaluation of dental growth observed from dental radiographs in children In order to estimate dental age, Demirjian's, Willems' and Nolla's methods were used. All panoramic radiographs were scored by one observer to eliminate the inter-observer error.


Eligibility criteria: Inclusion Criteria:

* good quality of panoramic radiographs, presence of all permanent mandibular and maxillar teeth except the third molars
* healthy children with normal eruption of teeth,
* children with similiar etnic origin and socio-economic status

Exclusion Criteria:

* Children with any syndromes, congenital or developmental anomalies and systemic diseases,
* Children undergoing or with previous orthodontic treatment history,
* Children with tooth agenesis, dental trauma history

Primary outcomes:
measure: Demirjian method
timeFrame: up to 3 years
Secondary outcomes:
measure: Willems method
timeFrame: up to 3 years
Other outcomes:
measure: Nolla method
timeFrame: up to 3 years
Locations:
city: Isparta
country: Turkey
facility: Suleyman Demirel University Faculty of Dentistry
Study officials:
References:
Clinical trial NCT01598558: Assessing Response to Treatment in Non-Hodgkin's Lymphoma Patients Using 64Cu-DOTA-Rituximab PET/CT
Official title: Assessing Response to Treatment in Non-Hodgkin's Lymphoma Patients Using 64Cu-DOTA-Rituximab PET/CT
Study type: INTERVENTIONAL
Overall status: WITHDRAWN
Phase: NA
Conditions: Non-Hodgkin's Lymphoma
Lead sponsor: Stanford University
Sponsor class: OTHER
First posted: 2012-05-15
Enrollment: 0
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NON_RANDOMIZED
Intervention model: SINGLE_GROUP
Primary purpose: DIAGNOSTIC

Brief summary: Rituximab is an antibody targeted against the CD20 antigen found primarily on B-cells. Therefore, an imaging agent targeting CD20 expression may provide a more accurate evaluation of extent of disease and response to therapy than the current standard of care, F-18 FDG PET/CT.

The main purpose of the study is to investigate a new PET/CT imaging probe for detection and follow up of lymphoma. Following are the 3 aims of the study: a) Phase I testing in lymphoma patients of Cu-64 labelled Rituxan for defining normal tracer biodistribution, stability, pharmacokinetics and radiation dosimetry; b) comparison of Cu-64 Rituxan and F-18 FDG PET/CT in lymphoma patients; c) evaluation of changes in uptake of Cu-64 Rituxan in response to rituximab-based treatment in CD20-positive B-cell NHL


Eligibility criteria: Inclusion Criteria:

* Patients must have a diagnosis of CD20-positive B-cell NHL and a staging 18F FDG PET/CT prior to the 64Cu-DOTA-Rituximab PET/CT
* Patients must understand and voluntarily sign an Informed Consent form after the contents have been fully explained to them
* Patients must be scheduled for rituximab-based therapy
* Patients must be older than 18-year-old

Exclusion Criteria:

* Patients who cannot complete a PET/CT scan
* Pregnant women
* Patients participating in other research protocols will be excluded from this study

Primary outcomes:
measure: Change in pre and post treatment SUV max value on the 64CU-DOTA-Rituximab PET/CT and 18F FDG PET/CT
timeFrame: baseline and 6 weeks
Secondary outcomes:
Other outcomes:
Locations:
city: Stanford
country: United States
facility: Stanford University Cancer Institute
state: California
Study officials:
affiliation: Stanford University
name: Sanjiv Gambhir, MD, PhD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT06961396: Impact of Virtual Reality on Painful Menstruation
Official title: Impact of Virtual Reality Combined With Manual Diaphragmatic Release on Adolescent Female With Painful Menstruation
Study type: INTERVENTIONAL
Overall status: RECRUITING
Phase: NA
Conditions: Painful Menstruation
Relaxation; Back Ligaments
Keywords: virtual reality
Diaphragmatic Releasing Technique
Painful Menstruation
Adolescent Female
Lead sponsor: New Ismailia National University
Sponsor class: OTHER
First posted: 2025-05-07
Enrollment: 200
Sex: FEMALE
Minimum age (years): 13
Maximum age (years): 20
Standard ages: CHILD
ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Intervention model description: Randomized Clinical Trial
Primary purpose: TREATMENT

Brief summary: To investigate the effect of virtual reality on painful menstruation in adolescent female

Detailed description: The focus of relatively recent work has been on non-pharmacological pain management techniques. The usage of virtual reality (VR) devices that can replicate three-dimensional (3D) immersive worlds is one particularly exciting advancement. This technology is becoming more widely available in healthcare settings and has shown promise in lowering pain and anxiety levels for people receiving minor gynecological disorders, dental work, burn wound care, and labor. So, the research purpose is targeted to look into the impact of virtual reality combined with diaphragmatic release as an active relaxation technique on painful menstruation in adolescent female

Eligibility criteria: Inclusion Criteria:

* age from 16 to 22 year
* cases of primary dysmenorrhea
* Normal body mass index (20-25)

Exclusion Criteria:

* cases with polycystic ovarian syndrome
* Obese female or body mass index more than 25
* severe bleeding with menstruation
* cases with low back pain due to orthopedic origin like disc herniation or spinal malalignment

Primary outcomes:
measure: pain intensity
timeFrame: 1o days for successive three months
Secondary outcomes:
measure: Menstrual Distress Questionnaire
timeFrame: 1o days for successive three months
Other outcomes:
Locations:
city: Ismailia
country: Egypt
facility: Mohamed Abdel Moenem Abo El Ros
city: Amman
country: Jordan
facility: Zaytona University in Jordon
Study officials:
affiliation: Al Zaytona University in Jordon
name: Hadeel MA Badwan, Ph.D
role: STUDY_CHAIR
References:
Clinical trial NCT02039596: Nutritional Metabolomics: the Search for Dietary Exposure Variables
Official title: Nutritional Metabolomics: the Search for Dietary Exposure Variables
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Nutrition Disorders
Metabolic Disorders
Lead sponsor: Göteborg University
Sponsor class: OTHER
First posted: 2014-01-17
Enrollment: 53
Sex: ALL
Minimum age (years): 18
Maximum age (years): 65
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: CROSSOVER
Primary purpose: BASIC_SCIENCE

Brief summary: In the post-genomic era, a major challenge for health research is to understand the complex interactions among genetic, environmental and lifestyle factors including dietary intake. Unfortunately, such initiatives are hampered by the lack of accurate dietary intake assessment methods for large studies. The newly emerging field of metabolomics offers unique possibilities to characterize individual food intake, dietary patterns and effects of dietary intervention in large studies. The investigators propose to develop a platform to detect broad metabolomic responses to food intake in controlled trials as well as to use targeted metabolomics approaches to characterize dietary intake in longitudinal studies. Our laboratory has a long history of developing methodology for assessing nutritional status and effects of diet on metabolism. Here, the investigators team up with the Sahlgrenska Academy Core Facility and the Swedish NMR Centre at the University of Gothenburg, that offer modern metabolomics equipment and competence in bioinformatics, and use this in the context of nutrition research. To their knowledge, the investigators are among the first groups in the country to develop skills in metabolomics to assess dietary intake and effects of nutrition on metabolism, and probably the first to use two complementary platforms with both mass-spectrometry and nuclear magnetic spectroscopy. Hence, our methodological results should be useful to nutritional scientists nationally as well as internationally.


Eligibility criteria: Inclusion Criteria:

* Body mass index 18.5-30.0
* Age 18-65 years old

Exclusion Criteria:

* Medications or tobacco use

Primary outcomes:
measure: Acute metabolomic response
timeFrame: Directly after ingestion of test meal
Secondary outcomes:
Other outcomes:
Locations:
city: Gothenburg
country: Sweden
facility: Dept Internal Medicine and Clinical Nutrition, Univ of Gothenburg
Study officials:
affiliation: Univ of Gothenburg, Sweden
name: Anna K Winkvist, PhD
role: PRINCIPAL_INVESTIGATOR
affiliation: Univ of Gothenburg
name: Lars H Ellegard, PhD, MD
role: STUDY_CHAIR
affiliation: Univ of Gothenburg
name: Helen M Lindqvist, PhD
role: STUDY_DIRECTOR
References:
citation: Radjursoga M, Lindqvist HM, Pedersen A, Karlsson GB, Malmodin D, Brunius C, Ellegard L, Winkvist A. The 1H NMR serum metabolomics response to a two meal challenge: a cross-over dietary intervention study in healthy human volunteers. Nutr J. 2019 Apr 8;18(1):25. doi: 10.1186/s12937-019-0446-2.
Clinical trial NCT05372796: The Effects of Transcutaneous Occipital Nerve Stimulation and Instrument-Assisted Soft Tissue Mobilization on Patients With Chronic Migraine
Official title: Effects of Transcutaneous Occipital Nerve Stimulation and Instrument-Assisted Soft Tissue Mobilization in Chronic Migraine
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Migraine
Lead sponsor: Okan University
Sponsor class: OTHER
Collaborators: name: KTO Karatay University
First posted: 2022-05-13
Enrollment: 45
Sex: FEMALE
Minimum age (years): 20
Maximum age (years): 50
Standard ages: ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: In this study, it was aimed to examine the effects of two different treatments applied to the neck region, which have been popular in recent years, on migraine.The study included 45 female patients aged 20-50 years with migraine complaints. The patients were divided into 3 randomized groups: control group (n=15), Instrument-Assisted Soft tissue Mobilization (EDYDM) group (n=15) and on Occipital nerve TENS (OTES) group(n=15).Each group was given home exercise to their treatment. Home exercises applied 1 time per day for 5 weeks. Each exercise in the exercise program was performed with 10 repetitions


Eligibility criteria: Inclusion Criteria:

* Be between the ages of 20-50
* International Classification of headache disorders, Third Edition (beta), using the criteria to be diagnosed with migraine without aura,
* migraine with a history of being at least an annual,
* VAS neck pain to be on Level 4,
* the hit-6 score is greater than 56

Exclusion Criteria:

* receiving pharmacological or non-pharmacological treatment regularly in the last three months,
* using a pacemaker,
* being an epileptic or severely psychiatric patient,
* conducting a surgical operation from the neck region,
* cervical disc degeneration or prolapse, the presence of different diagnoses of headaches

Primary outcomes:
measure: Visuel Analog Skale
timeFrame: Change from Baseline Pain at 5 weeks
Secondary outcomes:
measure: Headache effect test (HIT-6)
timeFrame: Change from baseline headache at 5 weeks
measure: Pittsburgh sleep quality index (PQI)
timeFrame: change from baseline sleep at 5 weeks
measure: SF 36
timeFrame: Change from baseline quality of life at 5 weeks
Other outcomes:
Locations:
city: Tuzla
country: Turkey
facility: Emine Atıcı
state: İstanbul
Study officials:
References:
Clinical trial NCT04366635: Evaluation of Two Different Grafting Techniques After Mandibular Impacted Third Molar Surgery
Official title: Evaluation of the Effectiveness of the Mineralized Plasmatic Matrix and Tricalcium Phosphate Graft Application After Mandibular Impacted Third Molar Surgery in Terms of Periodontal and Osseous Healing Distal to the Second Molar
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Periodontal Pocket
Impacted Third Molar Tooth
Impacted Teeth With Abnormal Position
Keywords: Mineralized Plasmatic Matrix, Beta-tricalcium phosphate
Lead sponsor: Konya Necmettin Erbakan Üniversitesi
Sponsor class: OTHER
First posted: 2020-04-29
Enrollment: 36
Sex: ALL
Minimum age (years): 18
Maximum age (years): 40
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: This study evaluates the effectiveness of using Mineralized Plasmatic Matrix and β-tricalcium phosphate that placed to extraction socket as a graft material in terms of periodontal damage occurred in the distal aspect of the second molar after mandibular impacted third molar surgery.


Eligibility criteria: Inclusion Criteria:

* Medically healthy.
* Periodontally healthy patients.
* Patients with mesioangular or horizontal impacted teeth that will cause periodontal damage at the distal part of the second molar after surgery.

Exclusion Criteria:

* Crowns on second molar teeth.
* Poor oral hygiene.
* Patients with a systemic disease affecting periodontal healing.
* Pregnancy or lactation period.
* Patients undergoing orthodontic treatment.
* Smokers.
* The cases where the buccal or lingual cortical bone didn't remain intact following the extraction were also excluded.

Primary outcomes:
measure: Periodontal pocket depth
timeFrame: At 0 day
measure: Alveolar bone level
timeFrame: At 0 day
Secondary outcomes:
measure: Periodontal pocket depth
timeFrame: At 6th month
measure: Alveolar bone level
timeFrame: At 6th month
Other outcomes:
Locations:
city: Konya
country: Turkey
facility: Necmettin Erbakan University, Faculty of dentistry
Study officials:
affiliation: Consultant
name: Kubilay Işık
role: STUDY_CHAIR
affiliation: Care Provider
name: Ali Kılınç
role: STUDY_DIRECTOR
References: