Clinical trial NCT06606717: Effects of Resistance-band Training and Creatine and Whey Protein
Official title: Effects of Resistance-band Training and Nutritional Supplementation in Healthy Older Adults
Study type: INTERVENTIONAL
Overall status: RECRUITING
Phase: NA
Conditions: Sarcopenia in Elderly
Keywords: Resistance Exercise
Creatine
Whey Protein
Strength
Lean Mass
Lead sponsor: University of Regina
Sponsor class: OTHER
Collaborators: name: Iovate Health Sciences International Inc
First posted: 2024-09-23
Enrollment: 36
Sex: ALL
Minimum age (years): 50
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The primary purpose of this research is to compare the effects of creatine monohydrate and/or whey protein supplementation during the first 10 weeks of a 20-week resistance-band training program on measures of body composition (whole-body lean tissue mass, total body water), arm and leg muscle thickness, upper- and lower-body muscle performance (i.e., strength, endurance) and functional ability (walking speed, balance). A secondary purpose of this research is to examine the effects of supplementation cessation (i.e., no creatine and/or whey protein supplementation) during the final 10 weeks of the 20-week resistance-band training program on these measures.

Detailed description: Sarcopenia, characterized by the age-related reduction in strength, muscle mass, and physical function, decreases the ability to perform activities of daily living. Physical inactivity and inadequate nutrition are contributing factors to the development of sarcopenia. Resistance training is a safe, viable and effective intervention which increases measures of muscle and bone mass, muscle performance (i.e., strength, endurance) and functional ability in older adults. However, older adults indicate that high costs and difficulty finding training programming and/or facilities are barriers to participating in resistance training. Home-based resistance-band training is safe, effective and serves as a viable alternative to traditional resistance training (i.e., involving free-weights and machine-based equipment). From a healthy aging perspective, resistance-band training elicits similar improvements in strength (primary indicator of sarcopenia) and functional ability compared to traditional resistance training in older adults. In addition to resistance training (involving resistance-bands), creatine and whey protein supplementations have also been shown to have favorable effects on measures of muscle, bone and functional ability in older adults. However, no study has examined the effects of resistance-band training and creatine and whey protein supplementation in older adults.

Eligibility criteria: Inclusion Criteria:

* Untrained (defined as those performing ≤ 1 resistance training session per week for ≥ 6 weeks prior to the start of the study)

Exclusion Criteria:

* Taking creatine monohydrate within 30 days prior to the start of the study
* Currently ingesting whey protein
* Have pre-existing allergies to latex, fruit, dairy, nuts, seafood and mustard

Primary outcomes:
measure: Whole-body lean mass (kg)
timeFrame: baseline, week 10, week 20
measure: Strength (kg)
timeFrame: baseline, week 10, week 20
measure: Endurance (number of repetitions to fatigue)
timeFrame: baseline, week 10, week 20
measure: Balance (Centre of Pressure)
timeFrame: baseline, week 10, week 20
measure: Hydration (kg)
timeFrame: baseline, week 10, week 20
measure: Gait Speed (meters)
timeFrame: baseline, week 10, week 20
measure: Muscle Hypertrophy (cm)
timeFrame: baseline, week 10, week 20
Secondary outcomes:
Other outcomes:
Locations:
city: Regina
country: Canada
facility: University of Regina
state: Saskatchewan
Study officials:
affiliation: University of Regina
name: Darren Candow
role: PRINCIPAL_INVESTIGATOR
References: