Clinical trial NCT05010941: Hypotension Prediction Index in Living Donor Liver Transplantation
Official title: Performance of the Hypotension Prediction Index in Living Donor Liver Transplantation
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Living Donor Liver Transplantation
Hypotension
Lead sponsor: Seoul National University Hospital
Sponsor class: OTHER
First posted: 2021-08-18
Enrollment: 20
Sex: ALL
Minimum age (years): 20
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Patients undergoing living donor liver transplantation

Brief summary: The Hypotension Prediction Index via the Edwards Hemosphere advanced monitoring system is monitored in living donor liver transplantation recipients. The Hypotension Prediction Index is analyzed to verify the performance in predicting hypotensive events.

Detailed description: Hypotensive events during surgery and anesthesia occur frequently and are associated with complications such as myocardial infarction, acute kidney injury, and increase in mortality. Therefore predicting and preventing hypotension can lead to better outcomes.

The Hypotension Prediction Index is monitored with the Edwards Hemosphere advanced monitoring system in living donor liver transplantation recipients via the radial artery. The monitor is blinded so that the anesthesiologist cannot see the index, and the anesthesiologist manages the blood pressure according to the institution's anesthetic protocol for liver transplantation. After the surgery is done, the Hypotension Prediction Index is analyzed to see how well the index predicted actual hypotension that occured during the liver transplantation surgery. Receiver operating characteristic curves are drawn to show the performance of the Hypotension Prediction Index in liver transplantation.

Eligibility criteria: Inclusion Criteria:

* Patients scheduled for living donor liver transplantation aged 20 years and older
* Patients who understand the trial and have given informed consent

Exclusion Criteria:

* Patients with arrhythmia or pacemaker

Primary outcomes:
measure: Prediction of Hypotension 5 Minutes Before the Event
timeFrame: During the surgery
Secondary outcomes:
measure: Prediction of Hypotension 10 Minutes Before the Event
timeFrame: During the surgery
measure: Prediction of Hypotension 15 Minutes Before the Event
timeFrame: During the surgery
Other outcomes:
Locations:
city: Seoul
country: Korea, Republic of
facility: Seoul National University Hospital
Study officials:
affiliation: Seoul National University Hospital
name: Hee Soo Kim
role: PRINCIPAL_INVESTIGATOR
References:
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