Clinical trial NCT01504230: Multi-joint Coordination Underlies Upright Balance Control in Elderly With Osteoporosis
Official title: Multi-joint Coordination Underlies Upright Balance Control in Elderly With Osteoporosis
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Osteoporosis
Keywords: To ascertain the mechanisms for effectively controlling balance in seniors with osteoporosis and to provide a basis for developing fall prevention programs.
To develop biomechanical models that control the entire body's center of mass (CoM) during upright quiet stance in seniors with osteoporosis.
To identify the mechanism to control the entire body's CoM after receiving a balance perturbation in seniors with osteoporosis.
Lead sponsor: National Taiwan University Hospital
Sponsor class: OTHER
First posted: 2012-01-05
Enrollment: 50
Sex: ALL
Minimum age (years): 65
Maximum age (years): 85
Standard ages: OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: COHORT
Time perspective: CROSS_SECTIONAL
Sampling method: PROBABILITY_SAMPLE
Study population: community sample

Brief summary: Osteoporosis is a prevalent health concern among older adults and is associated with an increased risk of falls that can cause fracture, injury and even mortality. Identifying the factors related to falls occur within this population is essential for the development of effective regimes for fall prevention. The long-term objectives of this work are to ascertain the mechanisms for effectively controlling balance in seniors with osteoporosis and to provide a basis for developing fall prevention programs. The entire body's center of mass (CoM) is a critical indicator for balance control and the coordination among joints and muscles to control the CoM is still unclear. The aim1 of this study is to develop biomechanical models that control the entire body's center of mass (CoM) during upright quiet stance in seniors with osteoporosis. The aim2 of this study is to identify the mechanism to control the entire body's CoM after receiving a balance perturbation in seniors with osteoporosis. The findings of this research can provide needed information regarding the processes of balance control in this vulnerable osteoporosis population, and has the potential to be applied to individuals with other neuromuscular and orthopedic deficits.


Eligibility criteria: Inclusion Criteria:

* for healthy older adults (OA)

  1. can stand for 5 minutes and walk for 6 minutes independently
  2. normal or corrected to normal vision
  3. an age between 65-85 years
  4. no osteoporosis (T-score above -2.5)
* for osteoporosis participants (OP)

  1. can stand for 5 minutes and walk for 6 minutes independently
  2. normal or corrected to normal vision
  3. an age between 65-85 years
  4. no osteoporosis (T-score below -2.5)

Exclusion Criteria:

1. pregnant women
2. cancer diagnosis
3. sensory-motor deficits
4. the BMI is larger than 30 or smaller than 18

Primary outcomes:
Secondary outcomes:
Other outcomes:
Locations:
city: Taipei
country: Taiwan
facility: School & Graduate Institute of Physical Therapy College of Medicine, National Taiwan University
Study officials:
affiliation: National Taiwan University Hospital
name: Wei-Li Hsu, PhD
role: PRINCIPAL_INVESTIGATOR
References: