Clinical trial NCT01158859: Effect of Preoperative Pregabalin on Propofol Induction Dose
Official title: Effect of Preoperative Pregabalin on Propofol Induction Dose
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE4
Conditions: Anesthesia, General
Laparoscopic Surgery
Keywords: Anesthesia, General
Propofol
Pregabalin
Preoperative care
Laparoscopic surgery
Lead sponsor: Université de Sherbrooke
Sponsor class: OTHER
First posted: 2010-07-08
Enrollment: 50
Sex: FEMALE
Minimum age (years): 18
Maximum age (years): 40
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The primary issue is to determine whether preoperatively administered pregabalin decreases the necessary dose of propofol during induction of general anesthesia. The investigators secondary issue is to test if preoperatively administered pregabalin decreases anxiety.


Eligibility criteria: Inclusion Criteria:

* Laparoscopic gynaecologic surgery
* Age 18-40 years
* ASA class I or II
* Body mass index 18-30

Exclusion Criteria:

* Allergic to pregabalin or gabapentin
* Chronic renal failure
* Alcohol or drug abuse
* Chronic analgesic use other than acetaminophen or NSAID
* Already taking gabapentin, pregabalin, benzodiazepin or antidepression drug
* Known neurological deficiency
* Suspected difficult intubation or ventilation
* Atypical pseudocholinesterases

Primary outcomes:
measure: Propofol induction dose
timeFrame: 1 hour
Secondary outcomes:
measure: Preoperative anxiety
timeFrame: 1 hour
Other outcomes:
Locations:
city: Sherbrooke
country: Canada
facility: Centre Hospitalier Universitaire de Sherbrooke
state: Quebec
Study officials:
affiliation: Centre de recherche du Centre hospitalier universitaire de Sherbrooke
name: Etienne de Medicis, MD MSc FRCPC
role: PRINCIPAL_INVESTIGATOR
References:
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