Clinical trial NCT06242015: Ordered Eating and Acute Exercise
Official title: The Effect of Ordered Eating on Postprandial Glucose and Substrate Utilization During an Acute Exercise Bout
Study type: INTERVENTIONAL
Overall status: RECRUITING
Phase: NA
Conditions: Glucose Metabolism Disorders
Hunger
Keywords: Exercise
Glucose
Fat metabolism
Hunger
Lead sponsor: Old Dominion University
Sponsor class: OTHER
First posted: 2024-02-05
Enrollment: 30
Sex: ALL
Minimum age (years): 18
Maximum age (years): 60
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: CROSSOVER
Primary purpose: BASIC_SCIENCE

Brief summary: There is well documented evidence that ingesting dietary carbohydrate in large amounts tends to increase postprandial glucose. In healthy populations, this is not necessarily a problem, but continuous exposure to high levels of glucose-hyperglycemia-is a defining characteristic and risk factor for type 2 diabetes mellitus. Consuming a carbohydrate-rich food as the final food in a meal sequence has been shown to significantly reduce postprandial glucose excursions in both diabetes patients and in healthy controls. The exact mechanisms behind this phenomenon are not well understood, but one proposed course is simply that the vegetable and protein already being digested slows the rate of glucose rise.

Despite the findings, little-to-no research has examined how manipulating the order of foods in a meal impacts subsequent exercise responses. In this experimental crossover study, each participant will undergo two acute feeding conditions (carbohydrate-rich foods first vs. last in a meal), which will be followed by exercise 60 minutes later. We will observe the effects of meal order on postprandial glucose, substrate/fuel utilization, and subjective perceptions at rest and during 30 minutes of exercise.


Eligibility criteria: Inclusion Criteria:

* Currently physically active (scheduled exercise at least three days per week for 30 minutes each time over the last three months)
* Ability to perform moderate-to-high intensity running for at least 30 minutes

Exclusion Criteria:

* Any allergy or other condition that would prohibit the consumption of poultry, rice, or broccoli
* Any injury or disease (cardiovascular disease, diabetes, pulmonary disease except controlled asthma) precluding physical exercise
* Currently pregnant
* Implanted electrical devices such as a pacemaker.

Primary outcomes:
measure: Postprandial glucose
timeFrame: 2 hours (premeal and 30, 60, 90, and 120 minutes after eating)
Secondary outcomes:
measure: Carbohydrate use
timeFrame: 100 minutes (premeal and continuously for 90 minutes after eating)
measure: Fat use
timeFrame: 100 minutes (premeal and continuously for 90 minutes after eating)
measure: Hunger-satiety perceptions
timeFrame: 2 hours (Premeal and at 15, 30, 45, 60, 68, 78, 88, 120 minutes after eating)
measure: Rating of perceived exertion
timeFrame: 30 minutes (at 8, 18, 28 minutes of exercise)
Other outcomes:
Locations:
city: Norfolk
country: United States
facility: ODU Human Performance Laboratory
state: Virginia
Study officials:
affiliation: Old Dominion University
name: Patrick Wilson
role: PRINCIPAL_INVESTIGATOR
References: