Clinical trial NCT06564142: Evaluation of Efficacy of Povetacicept in Adults With Immunoglobulin A Nephropathy (IgAN)
Official title: A Phase 3, Randomized, Double-blind, Placebo-controlled Study of Povetacicept in Adults With Immunoglobulin A Nephropathy (RAINIER)
Study type: INTERVENTIONAL
Overall status: RECRUITING
Phase: PHASE3
Conditions: Immunoglobulin A Nephropathy
Keywords: IgAN
Berger's disease
glomerulonephritis
IgA nephropathy
ALPN-303
BAFF
BLyS
APRIL
Lead sponsor: Alpine Immune Sciences, Inc.
Sponsor class: INDUSTRY
First posted: 2024-08-21
Enrollment: 480
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The purpose of this study is to evaluate the efficacy of povetacicept in adult participants compared with placebo in reducing proteinuria and preserving renal function.


Eligibility criteria: Key Inclusion Criteria:

* Diagnosed IgAN, with biopsy confirmation
* 24-hr proteinuria excretion ≥1.0 g/day or 24-hour uPCR ≥0.75 g/g
* Estimated glomerular filtration rate (eGFR) ≥ 30 mL/min/1.73m\^2
* Stable angiotensin converting enzyme inhibitor (ACEi) or angiotensin II receptor blocker (ARBs) as per protocol specification

Key Exclusion Criteria:

* Have received any immunosuppressive treatment or procedures (including corticosteroids, oral immunosuppressive agents, B cell or plasma cell targeted therapies, complement targeted therapies, herbal medicines per protocol, and tonsillectomy) within a wash-out period per protocol
* Rapidly progressive glomerulonephritis with eGFR reduction \>50% within 12 weeks of the start of screening

Other protocol defined Inclusion/Exclusion criteria may apply.

Primary outcomes:
measure: Change From Baseline in 24-hour Urine Protein to Creatinine Ratio (uPCR) at Week 36
timeFrame: From Baseline at Week 36
measure: Total Estimated Glomerular Filtration Rate (eGFR) Slope Through Week 104
timeFrame: From Baseline Through Week 104
Secondary outcomes:
measure: Change From Baseline in eGFR at Week 104
timeFrame: From Baseline at Week 104
measure: Time to Kidney Disease Progression Through Week 104
timeFrame: From Baseline Through Week 104
measure: Change From Baseline in Functional Assessment of Chronic Illness Therapy-Fatigue Score at Week 104
timeFrame: From Baseline at Week 104
Other outcomes:
Locations:
city: Huntsville
country: United States
facility: Apogee Clinical Research, LLC
state: Alabama
city: Phoenix
country: United States
facility: Arizona Kidney Disease and Hypertension Center - Thomas Office
state: Arizona
city: Tucson
country: United States
facility: Arizona Kidney Disease and Hypertension Center - Tuscon
state: Arizona
city: Fremont
country: United States
facility: West Coast Kidney
state: California
city: Fresno
country: United States
facility: The Medical Research Group, Inc. (FRENOVA)
state: California
city: Los Angeles
country: United States
facility: CARE Institute - Carabello Kidney
state: California
city: Orange
country: United States
facility: Providence Medical Foundation - Orange
state: California
city: Arvada
country: United States
facility: Western Nephrology
state: Colorado
city: Denver
country: United States
facility: Colorado Kidney Care
state: Colorado
city: Newark
country: United States
facility: Nephrology Associates Delaware Kidney
state: Delaware
city: Coral Springs
country: United States
facility: South Florida Nephrology Group PA, Research Div.
state: Florida
city: Doral
country: United States
facility: Dolphin Medical Research
state: Florida
city: Hollywood
country: United States
facility: Nephrology Associates of Central Florida
state: Florida
city: Hollywood
country: United States
facility: Tectum Medical Research, LLC
state: Florida
city: Lauderdale Lakes
country: United States
facility: South Florida Research Institute
state: Florida
city: Melbourne
country: United States
facility: Florida Kidney Physicians - Melbourne
state: Florida
city: Miami
country: United States
facility: Med-Care Research
state: Florida
city: Miami
country: United States
facility: Professional Research Center
state: Florida
city: Miami
country: United States
facility: Nephrology Associates of South Miami
state: Florida
city: Miami
country: United States
facility: On Health Research Center
state: Florida
city: Orlando
country: United States
facility: Combined Research Orlando Phase I-IV
state: Florida
city: Pembroke Pines
country: United States
facility: BioResearch Partner
state: Florida
city: Pompano Beach
country: United States
facility: D&H Pompano Research Center
state: Florida
city: Sweetwater
country: United States
facility: Cordova Research Institute, LLC
state: Florida
city: Atlanta
country: United States
facility: SciMerge Clinical Research
state: Georgia
city: Lawrenceville
country: United States
facility: Georgia Nephrology - Lawrenceville
state: Georgia
city: Newnan
country: United States
facility: Randomize Now - Midtown
state: Georgia
city: Chubbuck
country: United States
facility: Care Institute - Chubbuck, ID
state: Idaho
city: Idaho Falls
country: United States
facility: Care Institute - Idaho Falls
state: Idaho
city: Meridian
country: United States
facility: CARE - Boise Kidney Institute
state: Idaho
city: Naperville
country: United States
facility: Bioluminux Clinical Research
state: Illinois
city: Rockford
country: United States
facility: Rockford Nephrology Associates
state: Illinois
city: Indianapolis
country: United States
facility: Nephrology Associates of Northern Illinois and Indiana (NANI)
state: Indiana
city: Mishawaka
country: United States
facility: Nephrology Physicians LLC
state: Indiana
city: Louisville
country: United States
facility: Nephrology Associates of Kentuckiana
state: Kentucky
city: Baton Rouge
country: United States
facility: Renal Associates of Baton Rouge
state: Louisiana
city: Metairie
country: United States
facility: Velocity Clinical Research - Metairie
state: Louisiana
city: Baltimore
country: United States
facility: Johns Hopkins School of Medicine
state: Maryland
city: Shelby
country: United States
facility: St. Clair Nephrology Research
state: Michigan
city: Edina
country: United States
facility: InterMed Consultants / DaVita Clinical Research, Edina
state: Minnesota
city: Rochester
country: United States
facility: Mayo Clinic - Rochester
state: Minnesota
city: Tupelo
country: United States
facility: Nephrology and Hypertension Associates, LTD
state: Mississippi
city: Lincoln
country: United States
facility: Somnos Clinical Research
state: Nebraska
city: Las Vegas
country: United States
facility: DaVita Clinical Research Nevada - Las Vegas
state: Nevada
city: Hamilton
country: United States
facility: Bioluminux Clinical Research New Jersey
state: New Jersey
city: Jersey City
country: United States
facility: New Jersey Kidney Care, LLC (FRENOVA)
state: New Jersey
city: Albuquerque
country: United States
facility: Renal Medicine Associates
state: New Mexico
city: Albany
country: United States
facility: New York Nephrology Vasculitis and Glomerular Center
state: New York
city: Jamaica
country: United States
facility: Queens Hospital Center
state: New York
city: Charlotte
country: United States
facility: Metrolina Nephrology Associates
state: North Carolina
city: Philadelphia
country: United States
facility: Thomas Jefferson University
state: Pennsylvania
city: East Providence
country: United States
facility: Nephrology Associates Inc
state: Rhode Island
city: Providence
country: United States
facility: Hypertension & Nephrology Inc.
state: Rhode Island
city: Orangeburg
country: United States
facility: South Carolina Clinical Research, LLC
state: South Carolina
city: Knoxville
country: United States
facility: Knoxville Kidney Center (KKC), PLLC
state: Tennessee
city: Abilene
country: United States
facility: Velocity Clinical Research
state: Texas
city: Bellaire
country: United States
facility: Introscience Research LLC
state: Texas
city: Dallas
country: United States
facility: Dallas Renal Group
state: Texas
city: Dallas
country: United States
facility: Renal Disease Research Institute - Dallas
state: Texas
city: El Paso
country: United States
facility: Davita Clinical Research - El Paso
state: Texas
city: Houston
country: United States
facility: Prolato Clinical Research Center
state: Texas
city: Houston
country: United States
facility: Houston Medical Research Institute, LLC (FRENOVA)
state: Texas
city: Katy
country: United States
facility: R & H Clinical Research
state: Texas
city: Lewisville
country: United States
facility: North Texas Kidney Disease Associates
state: Texas
city: Lufkin
country: United States
facility: P&I Clinical Research, LLC
state: Texas
city: Pasadena
country: United States
facility: Renal Specialists of Houston
state: Texas
city: Salt Lake City
country: United States
facility: Utah Kidney Research Institute
state: Utah
city: Burlington
country: United States
facility: University of Vermont
state: Vermont
city: Fairfax
country: United States
facility: Virginia Nephrology Group
state: Virginia
city: Manassas
country: United States
facility: Kidney and Hypertension Specialist PLLC
state: Virginia
city: Ballarat
country: Australia
facility: Grampians Health Ballarat
city: Bendigo
country: Australia
facility: Bendigo Hospital
city: Birtinya
country: Australia
facility: Sunshine Coast University Hospital
city: Brisbane
country: Australia
facility: Core Research Group Pty Ltd
city: Camperdown
country: Australia
facility: Royal Prince Alfred Hospital
city: Clayton
country: Australia
facility: Monash Health
city: Concord
country: Australia
facility: Concord Repatriation General Hospital
city: Garran
country: Australia
facility: Canberra Hospital
city: Gosford
country: Australia
facility: Renal Research Gosford
city: Heidelberg
country: Australia
facility: Austin Hospital
city: Melbourne
country: Australia
facility: Western Health (Sunshine Hospital)
city: Murdoch
country: Australia
facility: Fiona Stanley Hospital
city: Newcastle
country: Australia
facility: John Hunter Hospital
city: Reservoir
country: Australia
facility: Melbourne Renal Research
city: Woolloongabba
country: Australia
facility: Princess Alexandra Hospital
city: Feldkirch
country: Austria
facility: LKH Feldkirch
city: Linz
country: Austria
facility: Ordensklinikum Linz GmbH Elisabethinen
city: Vienna
country: Austria
facility: Medizinische Universitaet Wien
city: Wels-Grieskirchen
country: Austria
facility: Klinikum Wels- Grieskirchen
city: Belo Horizonte
country: Brazil
facility: Freire Pesquisa Clinica
city: Belo Horizonte
country: Brazil
facility: Hospital Evangelico de Belo Horizonte
city: Brasilia
country: Brazil
facility: Associacao Ampara a Saude
city: Juiz de Fora
country: Brazil
facility: Centro Mineiro de Pesquisa
city: Rio de Janeiro
country: Brazil
facility: Hospital Universitario Pedro Ernesto - UERJ
city: Sao Paolo
country: Brazil
facility: Hospital Nove de Julho - DASA
city: Sao Paulo
country: Brazil
facility: Hospital das Clinicas da Faculdade de Medicina da Universidade de Sao Paulo
city: Hamilton
country: Canada
facility: St. Josephs Healthcare - Hamilton
city: Beijing
country: China
facility: Beijing Tsinghua Changgung Hospital
city: Beijing
country: China
facility: Peking University First Hos
city: Cangzhou
country: China
facility: Cangzhou People's Hospital
city: Changchun
country: China
facility: The Second Norman Bethune Hospital of Jilin University
city: Changzhi
country: China
facility: Heping Hospital Affiliated to Changzhi Medical College
city: Chengdu
country: China
facility: Sichuan People s Hospital
city: Chongqing
country: China
facility: Bishan Hospital of Chongqing
city: Chongqing
country: China
facility: The Second Affiliated Hospital of Chongqing Medical University
city: Dongguan
country: China
facility: Dongguan People s Hospital
city: Foshan
country: China
facility: The First People's Hospital of Foshan
city: Fuyang City
country: China
facility: Fuyang People's Hospital
city: Fuzhou
country: China
facility: Fujian Medical University Union Hospital
city: Guangzhou
country: China
facility: Guangdong Provincial People's Hospital
city: Guangzhou
country: China
facility: The First Affiliated Hospital of Guangzhou Medical University
city: Guangzhou
country: China
facility: Third Affiliated Hospital of Southern Medical University
city: Guangzhou
country: China
facility: Zhujiang Hospital, Southern Medical University
city: Guilin
country: China
facility: Affiliated Hospital of Guilin Medical University
city: Guiyang
country: China
facility: Guizhou Provincial People's Hospital
city: Hangzhou
country: China
facility: Sir Run Run Shaw Hospital Zhejiang University School of Medicine
city: Hefei
country: China
facility: The First Affiliated Hospital of Anhui Medical University
city: Hefei
country: China
facility: The Second Affiliated Hospital of Anhui Medical University
city: Hohhot
country: China
facility: The Affiliated Hospital of Inner Mongolia Medical University
city: Jinan
country: China
facility: The First Affiliated Hospital of Shandong First Medical University (Shandong Provincial Qianfoshan Hospital)
city: Jinan
country: China
facility: The Second Hospital of Shandong University
city: Lin Yi City
country: China
facility: Linyi People's Hospital
city: Luoyang
country: China
facility: The First Affiliate Hospital of Henan University of Science and Technology
city: Nanchang
country: China
facility: The First Affiliated Hospital of Nanchang University
city: Nantong City
country: China
facility: Affiliated Hospital of Nantong University
city: Ningbo
country: China
facility: Ningbo No.2 Hospital
city: Ningbo
country: China
facility: The First Affiliated Hospital of Ningbo University
city: Shaanxi
country: China
facility: The First Affiliated Hospital of Xian JiaoTong University
city: Shanghai
country: China
facility: Shanghai General Hospital
city: Shenyang
country: China
facility: Shengjing Hospital of China Medical University
city: Shenzhen
country: China
facility: The University of Hong Kong - Shenzhen Hospital
city: Shijiazhuang
country: China
facility: The Second Hospital of Hebei Medical University
city: Taian
country: China
facility: Taian City Central Hospital
city: Taiyuan
country: China
facility: Second Hospital of Shanxi Medical University
city: Tianjin
country: China
facility: The Second Hospital of Tianjin Medical University
city: Wuxi
country: China
facility: Wuxi People s Hospital
city: Xuancheng
country: China
facility: Xuancheng People s Hospital
city: Yancheng City
country: China
facility: Yancheng No. 1 People's Hospital
city: Yangzhou City
country: China
facility: Affiliated Hospital Yangzhou University
city: Yantai
country: China
facility: Yantai YuHuangDing Hospital
city: Yichang
country: China
facility: Yichang central people Hos
city: Yinchuan
country: China
facility: General Hospital of Ningxia Medical University
city: Zagreb
country: Croatia
facility: Clinical Hospital Dubrava
city: Zagreb
country: Croatia
facility: Polyclinic Somed
city: Nove Mesto
country: Czechia
facility: Vseobecna fakultni nemocnice v Praze
city: Nový Jičín
country: Czechia
facility: Nemocnice AGEL Novy Jicin a.s.
city: Aalborg
country: Denmark
facility: Aalborg University Hospital
city: Copenhagen
country: Denmark
facility: Center for Cancer and Organ Diseases - Rigshospitalet - Hornum Mads
city: Hillerod
country: Denmark
facility: Hillerod Hospital
city: Kolding
country: Denmark
facility: Sygehus Lillebaelt - Kolding
city: Tallin
country: Estonia
facility: North Estonia Medical Centre Foundation
city: Tartu
country: Estonia
facility: Tartu University Hospital
city: Bordeaux
country: France
facility: Groupe Hospitalier Pellegrin, CHU De Bordeaux
city: Creteil
country: France
facility: Hopitaux Universitaires Henri Mondor
city: Le Puy-en-Velay
country: France
facility: Centre Hospitalier Emile Roux
city: Marseille
country: France
facility: AP-HM - Hopital de La Conception
city: Nantes
country: France
facility: CHU de Nantes - Hotel-Dieu
city: Paris
country: France
facility: Hopital Necker - Enfants Malades
city: St Priest en Jarez
country: France
facility: Centre Hospitalier Universitaire (CHU) de Saint-Etienne - Hopital Nord
city: Valenciennes
country: France
facility: Centre Hospitalier de Valencienes
city: Aachen
country: Germany
facility: Medizinische Klinik II
city: Berlin
country: Germany
facility: Charite Universitaetsnedizin Berlin
city: Dresden
country: Germany
facility: Universitaetsklinikum Carl Gustav Carus Dresden
city: Hong Kong
country: Hong Kong
facility: Queen Mary Hospital
city: Shatin
country: Hong Kong
facility: Prince Wales Hospital
city: Sheung Wan
country: Hong Kong
facility: Tung Wah Hospital
city: Pecs
country: Hungary
facility: Pecsi Tudomanyegyetem Klinikai Kozpont
city: Galway
country: Ireland
facility: University Hospital Galway
city: Ashkelon
country: Israel
facility: Barzilai Medical Center
city: Petah Tivka
country: Israel
facility: Rabin Medical Center
city: Tel Hashomer
country: Israel
facility: Sheba Medical Center
city: Zerifin
country: Israel
facility: Shamir Medical Center
city: Genova
country: Italy
facility: Ospedale Policlinico San Martino IRCCS
city: Pavia
country: Italy
facility: Istituti Clinici Scientifici Maugeri-IRCCS Pavia
city: Aichi
country: Japan
facility: Fujita Health University Hos
city: Amagasaki
country: Japan
facility: Hyogo Amagasaki Gen Med Ctr
city: Fukuoka
country: Japan
facility: Fukuoka University Hospital
city: Fukuoka
country: Japan
facility: Japanese Red Cross Fukuoka Hospital
city: Itabashi-ku
country: Japan
facility: Nihon University Itabashi Hospital
city: Kahoku
country: Japan
facility: Kanazawa Medical Uni Hospital
city: Kanazawa
country: Japan
facility: Kanazawa University Hospital
city: Kashihara
country: Japan
facility: Nara Med University Hos
city: Kasugai
country: Japan
facility: Kasugai Municipal Hospital
city: Kita-ku
country: Japan
facility: Okayama University Hospital
city: Kitakyushu-shi
country: Japan
facility: Kokura Memorial Hospital
city: Kobe
country: Japan
facility: Kobe University Hospital
city: Koshigaya
country: Japan
facility: Dokkyo Medical University Saitama Medical Center
city: Kyoto-shi
country: Japan
facility: Japanese Red Cross Kyoto Daini Hospital
city: Kyoto
country: Japan
facility: Kyoto University Hospital
city: Miyazaki
country: Japan
facility: University of Miyazaki Hos
city: Osaka
country: Japan
facility: Osaka City General Hospital
city: Osaka
country: Japan
facility: Osaka General Medical Center
city: Sapporo-shi
country: Japan
facility: Sapporo City General Hospital
city: Sendai-shi
country: Japan
facility: Tohoku University Tohoku University Hospital
city: Tokyo
country: Japan
facility: Juntendo Hospital Affiliated to Juntendo University School of Medicine
city: Tokyo
country: Japan
facility: Juntendo University Nerima Hospital
city: Tokyo
country: Japan
facility: The Jikei Uni Daisan Hospital
city: Tokyo
country: Japan
facility: The Jikei University Hospital
city: Tokyo
country: Japan
facility: Tokyo Med University Hospital
city: Tokyo
country: Japan
facility: Tokyo Women's Medical University Hospital
city: Tomigusuku
country: Japan
facility: YUUAI Medical Center
city: Toyama-shi
country: Japan
facility: Toyama Prefectural Central Hospital
city: Urayasu-shi
country: Japan
facility: Juntendo Uni Urayasu Hospital
city: Anyang
country: Korea, Republic of
facility: Hallym University Sacred Heart Hospital
city: Cheonan
country: Korea, Republic of
facility: Seoul National University Hospital
city: Cheonan
country: Korea, Republic of
facility: Soon Chun Hyang University Cheonan Hospital
city: Daegu
country: Korea, Republic of
facility: Keimyung University Dongsan Medical Center
city: Daegu
country: Korea, Republic of
facility: Kyungpook National University Hospital
city: Daejeon
country: Korea, Republic of
facility: Konyang University Hospital
city: Gangwon-do
country: Korea, Republic of
facility: Hallym University Chuncheon Sacred Heart Hospital
city: Gangwon-do
country: Korea, Republic of
facility: Wonju Severance Christian Hospital
city: Goyang-si
country: Korea, Republic of
facility: NHIS Ilsan Hospital
city: Seongnam-si
country: Korea, Republic of
facility: Seoul National University Bundang Hospital
city: Seoul
country: Korea, Republic of
facility: Asan Medical Center
city: Seoul
country: Korea, Republic of
facility: Chung-Ang University Hospital
city: Seoul
country: Korea, Republic of
facility: Konkuk University Medical Center
city: Seoul
country: Korea, Republic of
facility: Korea University Guro Hospital
city: Seoul
country: Korea, Republic of
facility: Korea University Medical Center (KUMC)-Korea University Anam Hospital
city: Seoul
country: Korea, Republic of
facility: Kyung Hee University Hospital at Gangdong (KUIMS)
city: Seoul
country: Korea, Republic of
facility: Samsung Medical Center
city: Seoul
country: Korea, Republic of
facility: Severance Hospital, Yonsei University Health System
city: Seoul
country: Korea, Republic of
facility: The Catholic University of Korea Eunpyeong St. Mary's Hospital
city: Seoul
country: Korea, Republic of
facility: The Catholic University of Korea, Seoul ST. Mary's Hospital
city: Suwon
country: Korea, Republic of
facility: Ajou University Hospital
city: Yongin-Si
country: Korea, Republic of
facility: Yongin Severance Hospital
city: Riga
country: Latvia
facility: Paula Stradina Clinical University Hospital
city: Kaunas
country: Lithuania
facility: Hospital of Lithuanian University of Health Sciences (LSMU) Kauno klinikos
city: Vilnius
country: Lithuania
facility: Vilnius University Hospital Santaros Klinikos
city: Veracruz
country: Mexico
facility: Arke SMO SA de CV
city: Groningen
country: Netherlands
facility: University Medical Center Groningen
city: Nijmegen
country: Netherlands
facility: UMC St. Radboud
city: Bergen
country: Norway
facility: Haukeland University Hospital
city: Oslo
country: Norway
facility: Oslo University Hospital - Ulleval Hospital
city: Krakow
country: Poland
facility: SCM Sp. Z o.o
city: Warszawa
country: Poland
facility: Panstwowy Instytut Medyczny MSWiA - Klinika Chorob Wewnetrznych, Nefrologii i Transplantologii
city: Zamosc
country: Poland
facility: Velocity Zamosc
city: Barcelona
country: Spain
facility: Hospital Universitatio Vall d'Hebron
city: Lleida
country: Spain
facility: Hospital Universitari Arnau de Vilanova - Lleida
city: Madrid
country: Spain
facility: Clinica Universidad de Navarra - Madrid
city: Madrid
country: Spain
facility: Hospital Fundacion Jimenez Diaz
city: Madrid
country: Spain
facility: Hospital Universitario Puerta de Hierro
city: Madrid
country: Spain
facility: Hospital Universitario Ramon y Cajal
city: Pamplona
country: Spain
facility: Clinica Universidad de Navarra - Pamplona
city: Santiago de Compostela
country: Spain
facility: Hospital Clinico Universitario de Santiago
city: Sevilla
country: Spain
facility: Hospital Universitario Virgen Macarena
city: Valencia
country: Spain
facility: Hospital Universitario Doctor Peset
city: Danderyd
country: Sweden
facility: Nephrology Clinic, Danderyd University Hospital
city: Goteborg
country: Sweden
facility: Sahlgrenska University Hospital
city: Huddinge
country: Sweden
facility: Karolinska University Hospital Huddinge
city: Linköping
country: Sweden
facility: Linkoping University Hospital
city: Uppsala
country: Sweden
facility: Uppsala University Hospital
city: New Taipei City
country: Taiwan
facility: Shuang Ho Hospital
city: Taichung
country: Taiwan
facility: Tungs' Taichung Metroharbour Hospital
city: Taipei
country: Taiwan
facility: National Taiwan University Hospital (NTUH)
city: Taipei
country: Taiwan
facility: Taipei Medical University Hospital
city: Taipei
country: Taiwan
facility: Taipei Veterans General Hospital (TP-VGH)
city: Ankara
country: Turkey
facility: Hacettepe University Hospital
city: Istanbul
country: Turkey
facility: Istanbul University Cerrahpasa Medical Faculty
city: Kocaeli
country: Turkey
facility: Kocaeli University Medical School
city: Birmingham
country: United Kingdom
facility: FutureMeds - Soho Road Health Centre
city: Bristol
country: United Kingdom
facility: Southmead Hospital
city: Cambridge
country: United Kingdom
facility: Cambridge University - Addenbrooke's Hospital
city: Glasgow
country: United Kingdom
facility: FutureMeds - CPS Research
city: Glasgow
country: United Kingdom
facility: Queen Elizabeth University Hospital - Glasgow
city: London
country: United Kingdom
facility: Barts Health NHS Trust
city: London
country: United Kingdom
facility: King's College Hospital
city: London
country: United Kingdom
facility: St Pancras Clinical Research
city: Newcastle-Upon-Tyne
country: United Kingdom
facility: FutureMeds Newcastle
city: Stockton on Tees
country: United Kingdom
facility: FutureMeds Tesside
city: Wirral (Liverpool)
country: United Kingdom
facility: FutureMeds Liverpool
Study officials:
References: