louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT00862030: CT-Based Versus Conventional Simulation for Palliative Radiotherapy of Non-Small Cell Lung Cancer
Official title: Comparison of Two-versus Three-Dimensional Treatment Planning for Patients Receiving Chest Radiotherapy for Symptom Control
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Non-small Cell Lung Cancer
Keywords: Palliative radiotherapy
Treatment planning
Non-small cell lung cancer
Lead sponsor: AHS Cancer Control Alberta
Sponsor class: OTHER
First posted: 2009-03-16
Enrollment: 20
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: CROSS_SECTIONAL
Sampling method: NON_PROBABILITY_SAMPLE
Study population: 20

Brief summary: Radiotherapy (RT) treatment to the chest is a standard way of trying to decrease symptoms like cough or shortness of breath. Before any RT can be delivered, it must be planned, either using conventional x-rays ("fluoroscopy") or using computer tomography ("CT") scanning. This study is being done because the investigators do not know which of these two common ways of RT planning is better for balancing both treating the cancer and decreasing side effects.

Detailed description: Standard RT planning will be performed under conventional simulation, followed by CT-simulation (for study purposes only). Retrospectively, 3D treatment fields will be designed using the CT-simulation data, and compared to the actual treatment fields planned using x-rays. Coverage of the tumour volume will be assessed, together with doses, field sizes and beam positions, to determine relative undercoverage of tumour and overcoverage of normal tissue between the two planning methods, if any.

Eligibility criteria: Inclusion Criteria:

* Patients with local symptoms secondary to histologically-confirmed non-small cell lung cancer
* Patients who will be receiving palliative-intent external beam radiotherapy
* Patients who are clinically appropriate for conventional radiotherapy planning
* Patients who can provide written informed consent

Exclusion Criteria:

* Patients who cannot provide written informed consent

Primary outcomes:
Secondary outcomes:
Other outcomes:
Locations:
city: Edmonton
country: Canada
facility: Cross Cancer Institute
state: Alberta
Study officials:
affiliation: AHS Cancer Control Alberta
name: Dr. Alysa Fairchild, MD FRCPC
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT03848130: Effects of Lateral Wedge Insoles, Knee Taping on the Management of Knee Osteoarthritis
Official title: Effects of Lateral Wedge Insoles, Knee Taping on the Management of Knee Osteoarthritis
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Medial Compartment Knee Osteoarthritis
Keywords: Knee osteoarthritis
Knee injury and Osteoarthritis Outcome Score
Rapid assessment of physical activity
Quality of life
Traditional physiotherapy
Lead sponsor: Isra University
Sponsor class: OTHER
First posted: 2019-02-20
Enrollment: 60
Sex: ALL
Minimum age (years): 40
Maximum age (years): 70
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: Knee osteoarthritis (OA) is a degenerative, progressive and wide spread disease, which may lead the patient to severe outcomes e.g. pain, loss of joint motion, inflexibility, disability and decreases the quality of life (QOL). As it affects the adults of older age, therefore should be emphasized.Effectiveness of Mulligan knee taping, lateral wedge insoles and traditional physical therapy(Ultrasound therapy with stretching and strengthening exercises) with home exercises as baseline treatment were assessed through RAPA and complete KOOS questionnaire.

Detailed description: A total of 60 patients with medial compartment 3rd grade knee osteoarthritis were recruited and randomly divided into three groups, 20 in each group.The data was collected through general demographic questionnaire, rapid assessment of physical activity (RAPA) to determine physical activity level and Knee injury and Osteoarthritis Outcome Score (KOOS) to determine the level of pain severity, stiffness, functional activities, recreational activities and Quality of life for enhancing functional independence while having osteoarthritis. For between-group analysis, one way ANOVA was used and for within-group analysis longitudinal repeated measures analysis of variance (RM-ANOVA) with Tukey's multiple comparisons test was used.

Eligibility criteria: Inclusion Criteria:

* Knee OA in the age group of 40-70 year.
* Knee OA due to aging.
* Knee OA due to family history

Exclusion Criteria:

* Knee OA due to Trauma.
* Knee OA due to any knee pathology.

Primary outcomes:
measure: Knee injury and osteoarthritis outcome pain score
timeFrame: Upto 4 weeks
measure: Knee injury and osteoarthritis outcome stiffness score
timeFrame: Upto 4 weeks
measure: Knee injury and osteoarthritis outcome functional status score
timeFrame: Upto 4 weeks
measure: Knee injury and osteoarthritis outcome quality of life score
timeFrame: Upto 4 weeks
Secondary outcomes:
measure: Rapid Assessment Physical Activity scale
timeFrame: Upto 4 weeks
Other outcomes:
Locations:
city: Rawalpindi
country: Pakistan
facility: Rabbiya Riaz
state: Punjab
Study officials:
References:
Clinical trial NCT03605030: Reducing Radiation Exposure to Operators During Invasive Cardiac Procedures
Official title: Reducing Radiation Exposure to Operators During Invasive Cardiac Procedures With a Novel Lead-Based Arm-Board
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Patients Undergoing Invasive Cardiac Procedures
Radiation Exposure
Keywords: Cardiac Catheterization
Percutaneous Coronary Intervention
Radiation
Lead Shielding
Lead sponsor: London Health Sciences Centre
Sponsor class: OTHER
Collaborators: name: Western University, Canada
First posted: 2018-07-30
Enrollment: 360
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: PREVENTION

Brief summary: The primary objective of this study is to determine if a novel lead-based arm board is effective at reducing radiation dose to the operator during invasive cardiac procedures. Secondary objectives are to measure effect on radiation dose to patient and total fluoroscopy (x-ray) time.


Eligibility criteria: Inclusion Criteria:

* Age \> 18
* Planned invasive cardiology procedure, cardiac catheterization with or without percutaneous coronary intervention (PCI), or PCI alone.

Exclusion Criteria:

* Inability to provide consent

Primary outcomes:
measure: Radiation dose (μSv) to the operator at the chest
timeFrame: At procedure completion
measure: Radiation dose (μSv) to the operator at the forearm level
timeFrame: At procedure completion
Secondary outcomes:
measure: Air kerma
timeFrame: At procedure completion
measure: Dose area product
timeFrame: At procedure completion
measure: Radiation dose to the patient
timeFrame: At procedure completion
Other outcomes:
Locations:
city: London
country: Canada
facility: London Health Sciences Centre
state: Ontario
Study officials:
affiliation: London Health Sciences Centre, Western University, London, ON
name: Pallav Garg, MBBS, MSc
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT03076125: Stroke COunseling for Risk REduction
Official title: Stroke Counseling for Risk Reduction in Young Adult African Americans
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Stroke
Keywords: Primary Stroke Prevention, Risk Factors for Stroke
Lead sponsor: Georgia State University
Sponsor class: OTHER
First posted: 2017-03-10
Enrollment: 116
Sex: ALL
Minimum age (years): 20
Maximum age (years): 35
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Intervention model description: randomized controlled two-group pre-post test design
Primary purpose: PREVENTION

Brief summary: The purpose of this study is to test the efficacy of the Stroke Counseling for Risk Reduction (SCORRE) intervention in increasing accuracy of perceived stroke risk and promoting lifestyle behavior change to reduce stroke risk in young adult African Americans.


Eligibility criteria: Inclusion Criteria:

* self-identify as African American/Black
* age 20-35 years
* able to complete two study visits lasing 1 1/2- 2 hours and a brief daily diary for 8 weeks
* has a cell phone or email address to receive weekly reminders and tips
* has at least one modifiable risk factor for stroke identified during study visit one screening

Primary outcomes:
measure: Accuracy of perceived stroke risk
timeFrame: immediately post-intervention
measure: Targeted health behaviors
timeFrame: 8 weeks
Secondary outcomes:
Other outcomes:
Locations:
city: Atlanta
country: United States
facility: Georgia State University
state: Georgia
Study officials:
References:
Clinical trial NCT06964425: Raman Spectroscopy in the Diagnosis of Extrahepatic Cholangiocarcinoma - a Pilot Study
Official title: Raman Spectroscopy in the Diagnosis of Extrahepatic Cholangiocarcinoma
Study type: INTERVENTIONAL
Overall status: RECRUITING
Phase: NA
Conditions: Cholangiocarcinoma, Extrahepatic
Cholangiocarcinoma of the Extrahepatic Bile Duct
Cholangiocarcinoma, Perihilar
Diagnosis
Raman Spectroscopy
Klatskin Tumor
Endoscopy
Biliary Stricture
Malignant Biliary Stricture
Lead sponsor: University Hospital Olomouc
Sponsor class: OTHER
Collaborators: name: Palacky University
First posted: 2025-05-09
Enrollment: 20
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Intervention model description: 20 patients with known extrahepatic cholangiocarcinoma, over 18 years of age
Primary purpose: DIAGNOSTIC

Brief summary: Diagnosis of extrahepatic cholangiocarcinoma is challenging because the yield of imaging and tissue sampling is limited. Raman spectroscopy is an optical method based on the analysis of scattered monochromatic light. Raman spectroscopy is able to provide a molecular 'fingerprint' of the tissue to determine its type. The aim of this pilot study was to develop a methodology for in vivo Raman spectroscopy in bile ducts to improve the current diagnostic capabilities of extrahepatic cholangiocarcinoma.

Detailed description: During ERCP, a fibre Raman probe (Endoscopic Fiber-Optic Raman Probe Bundle Fiber, Uni-Export Instruments, USA) is introduced transpapillary into the known extrahepatic cholangiocarcinoma. The Raman probe is placed in an adequate position under fluoroscopy control. Raman spectroscopy measurements are performed (without fluoroscopy) 20 times for each patient (laser wavelength 785 nm), 10 times for extrahepatic cholangiocarcinoma and 10 times for healthy bile duct. The attained data are saved and analysed by a specialised biophysicist. All patients provided informed consent.

Eligibility criteria: Inclusion Criteria:

* person older than 18 years, who has known extrahepatic cholangiocarcinoma and is indicated for ERCP

Exclusion Criteria:

* disagreement with the study

Primary outcomes:
measure: The differences in Raman spectra of malignant biliary tissue compared to healthy biliary tissue
timeFrame: Perioperative/Periprocedural
Secondary outcomes:
Other outcomes:
Locations:
city: Olomouc
country: Czechia
facility: Peter Slodička
state: Olomoucký kraj
Study officials:
affiliation: University Hospital Olomouc
name: Peter Slodička, M.D.
role: PRINCIPAL_INVESTIGATOR
References:
citation: Slodicka P, Falt P, Ranc V, Zoundjiekpon VD, Urban O. Raman spectroscopy in the diagnosis of malignant biliary stricture: A feasibility study. Hepatobiliary Pancreat Dis Int. 2025 Apr;24(2):211-216. doi: 10.1016/j.hbpd.2024.11.003. Epub 2024 Nov 16. No abstract available.
Clinical trial NCT01767025: The Influence of Oxytocin on Automatic Imitation Behaviour in Healthy Adults
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE3
Conditions: Healthy
Keywords: Influence
oxytocin
automatic imitation
behaviour
volunteers
Lead sponsor: University Ghent
Sponsor class: OTHER
Collaborators: name: Research Foundation Flanders
First posted: 2013-01-11
Enrollment: 60
Sex: MALE
Minimum age (years): 18
Maximum age (years): 40
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: BASIC_SCIENCE

Brief summary: In this study, the influence of oxytocin on automatic imitation behaviour is investigated. Healthy adults will be administered with either oxytocin or a placebo, and will perform an imitation-inhibition task (as a measure of automatic imitation behaviour). To determine the specificity of the oxytocin effect, an unrelated cognitive task (Stroop task) will also be presented.


Eligibility criteria: Inclusion Criteria:

* Male
* non-smoker

Exclusion Criteria:

* no pacemaker, deep brain stimulation electrodes or other stimulation devices
* normal neurological history (no brain operations, migraine, epilepsy, alcoholism
* no epilepsy in family
* no chronic disease(s) that require constant medication (asthma, hypertension, diabetes)
* no medication 24h prior to experiment
* no alcohol or caffeine 2h prior to experiment
* no sleep deprivation 24h prior to experiment

Primary outcomes:
measure: To evaluate the automatic imitation behaviour 45 minutes after drug administration
timeFrame: 120 minutes
Secondary outcomes:
Other outcomes:
Locations:
city: Ghent
country: Belgium
facility: Ghent University, Faculty of Psychology and Educational Sciences
Study officials:
affiliation: Ghent University, Faculty of Endrocrinology
name: Guy T'Sjoen, MD, PhD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT01839825: Comparative Study of QuietCare
Official title: Randomized Comparative Study of QuietCare (Motion Sensor System) in Elderly Subjects Living in Assisted/ Independent Living Facilities
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Elderly People
Living Alone in a Residence With Care Giver
Keywords: elderly
fall
acute illness
care giver
Lead sponsor: National Center for Geriatrics and Gerontology, Japan
Sponsor class: OTHER
Collaborators: name: GE Healthcare
First posted: 2013-04-25
Enrollment: 202
Sex: ALL
Minimum age (years): 65
Standard ages: OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: HEALTH_SERVICES_RESEARCH

Brief summary: The objective of the study is to examine the efficacy and safety of QuietCare in a randomized, open study in elderly subjects living in assisted/ independent living facilities for 6 months.


Eligibility criteria: Inclusion Criteria:

1. ability to move independently or by using a walker (without assistance) inside
2. residents using a single room, age 65 or older, of either sex

Exclusion Criteria:

* people who use wheel chairs,
* people who are bed-ridden

Primary outcomes:
measure: Changes in score of Care Service Quetionnaire
timeFrame: The observation period is 6 months.
measure: Time required for staff to respond to events
timeFrame: The observation period is 6 months.
measure: Incidence of falls
timeFrame: The observation period is 6 months
Secondary outcomes:
measure: Fee for medical and nursing care treatments
timeFrame: The observation period is 6 months
Other outcomes:
Locations:
city: Fukuoka
country: Japan
facility: Sun Home Ogori
Study officials:
References:
Clinical trial NCT03550625: Computer Assisted Selection of Serrated Adenomas and Neoplastic Polyps - a New Clinical DRAft
Official title: Computer Assisted Selection of Serrated Adenomas and Neoplastic Polyps - a New Clinical Draft
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Polyps
Adenoma Colon
Automatic Judgement
Colonic Neoplasms
Lead sponsor: Technical University of Munich
Sponsor class: OTHER
First posted: 2018-06-08
Enrollment: 300
Sex: ALL
Minimum age (years): 18
Maximum age (years): 99
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: RETROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Patients presenting for routine colonoscopy

Brief summary: The aim of the study is to develop a computer program which is able to classify different entities of colorectal polyps on the basis of optical polyp features. In the end, the computer program shall differentiate between (i) hypeplastic polyps, (ii) adenomas and (iii) serrated adenomas .

In the first phase of the study a computer program will be established which aims to distinguish between the above mentions entities on the basis of optical features derived from still images. A machine learning apporach will be used for creating the program. Afterwards, in a second phase of the study, still images of 100 polyps (not used in the first phase) will be presented to the computer program. Quality of the computer program will be tested by calculating the accuracy for differentiating the three different polyp types. The gold standard for true polyp diagnoses will be based on histopathological diagnoses of the polyps. The same pictures of 100 polyps will also be presented to human experts. Experts will also predict histopathological diagnoses on the basis of optical polyps featurs. Accuracy of computer-decisions and human expert predictions will be compared. The establishment of a well- functioning computer program is the primary aim of the study.


Eligibility criteria: Inclusion Criteria:

* indication for colonoscopy
* patients \>= 18 years

Exclusion Criteria:

* pregnant women
* indication for colonoscopy: inflammatory bowel disease
* indication for colonoscopy: polyposis syndrome
* indication for colonoscopy: emergency colonoscopy e.g. acute bleeding
* contraindication for polyp resection e.g. patients on warfarin

Primary outcomes:
measure: Assessment of the computer- made optical diagnosis of each colorectal polyp
timeFrame: participants data will be followed for the duration of creating the computer program (an expected average of 2 month)
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
References:
Clinical trial NCT05811325: Kinesio Taping With &Without Craniosacral Therapy in Pregnant Females With SIJ Dysfunction.
Official title: Effect of Kinesio Taping With and Without Craniosacral Therapy on Pain, Disability, and Quality of Life in Pregnent Female With Sacroiliac Joint Dysfunction
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Sacral Disorder
Keywords: Sacro-iliac dysfunction
Lead sponsor: Riphah International University
Sponsor class: OTHER
First posted: 2023-04-13
Enrollment: 30
Sex: FEMALE
Minimum age (years): 18
Maximum age (years): 35
Standard ages: ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: SIJ dysfunction adversely affects quality of life and causes functional impairment and disability. Although, K taping and craniosacral therapy were previously affective in treating SI joint dysfunction, the combined affects of these intervention have not been compared previously to K taping alone.

Detailed description: This study is a randomized controlled trial and have 30 pregnant women suffering from SIJH dysfunction. There is 2 groups and both have received treatment for 6 weeks. The data on pain is collected through VAS and the data on disability is collected through Oswestry Disability Index, and data on quality of life will be collected using SF-36. Measurements will be taken at the beginning of the study and at the end of the 4th week, at the completion of the study. Data will be analyzed using SPSS.

Eligibility criteria: Inclusion Criteria:

* age between 18-35
* pregnant females in 3rd trimester
* pregnant females with SIJ dysfunction

Exclusion Criteria:

* high risk pregnancy
* pregnant females with hypermobility syndrome
* previous pelvic history

Primary outcomes:
measure: VISUAL ANALOGUE SCALE
timeFrame: 6 WEEKS
measure: Oswestry Disability Index
timeFrame: 4 weeks
Secondary outcomes:
measure: SF-36
timeFrame: 4 weeks
Other outcomes:
Locations:
city: Lahore
country: Pakistan
facility: Mayo Hopital
Study officials:
affiliation: ripah international university
name: tahreem Masood
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT04131725: Cardiac Function Non-Invasive Monitoring System Evaluation Trial
Official title: Cardiac Function Monitoring System Evaluation
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Cardiac Disease
Lead sponsor: Sensydia Corporation
Sponsor class: INDUSTRY
Collaborators: name: University of Pittsburgh Medical Center
First posted: 2019-10-18
Enrollment: 275
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: CASE_ONLY
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Patients scheduled for Pulmonary Artery Catheter procedure

Brief summary: Non-significant risk device study to conduct evaluation of the performance of new device for monitoring of cardiac function (based on previous iterations 510(k) 173156)

Detailed description: Non-significant risk device study to conduct evaluation of the performance of new device for monitoring of cardiac function (based on previous iterations 510(k) 173156)

Eligibility criteria: Inclusion Criteria:

* Adults of age 18 or older

Exclusion Criteria:

* Subjects with wounds or surgical incisions at the site of sensor placement

Primary outcomes:
measure: Cardiac Performance System electronic data for Cardiac Output
timeFrame: 60 minutes during Pulmonary Artery Catheter procedure
measure: Cardiac Performance System electronic data for Pulmonary Artery Pressure
timeFrame: 60 minutes during Pulmonary Artery Catheter procedure
measure: Cardiac Performance System electronic data for Pulmonary Artery Wedge Pressure
timeFrame: 60 minutes during Pulmonary Artery Catheter procedure
measure: Pulmonary Artery Catheter electronic data for Cardiac Output
timeFrame: 60 minutes during Pulmonary Artery Catheter procedure
measure: Pulmonary Artery Catheter electronic data for Pulmonary Artery Pressure
timeFrame: 60 minutes during Pulmonary Artery Catheter procedure
measure: Pulmonary Artery Catheter electronic data for Pulmonary Artery Wedge Pressure
timeFrame: 60 minutes during Pulmonary Artery Catheter procedure
measure: Echocardiography electronic data for Ejection Fraction
timeFrame: 15 minutes at a time prior to or after Pulmonary Artery Catheter procedure
Secondary outcomes:
Other outcomes:
Locations:
city: Pittsburgh
country: United States
facility: University of Pittsburgh Medical Center
state: Pennsylvania
Study officials:
affiliation: Sensydia Corporation
name: William Kaiser, PhD
role: PRINCIPAL_INVESTIGATOR
References: