louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT02169375: Sensorimotor Based Brain Computer Interface
Official title: Effect of Normalizer Adaptation on Accuracy in a Sensorimotor Based Brain-Computer Interface
Study type: INTERVENTIONAL
Overall status: TERMINATED
Phase: NA
Conditions: Healthy Volunteers
Lead sponsor: University of Michigan
Sponsor class: OTHER
Collaborators: name: Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
First posted: 2014-06-23
Enrollment: 6
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: SINGLE_GROUP
Primary purpose: BASIC_SCIENCE

Brief summary: Sensorimotor (also know as mu) rhythm based brain-computer interfaces (BCIs) are a tool for controlling electronic devices using only brain signals. Often, the computer software that analyzes mu-rhythm brain signals constantly adapts to the individual user's brain signals when the training target location is known. The investigators want the BCIs to be more universal, and not depend on knowing the target location. Therefore, the investigators will test the effect removing adaptation has on accuracy of using a mu-rhythm BCI.


Eligibility criteria: Inclusion Criteria:

* Age 18 or older.
* Able to read text on a computer screen
* Able to understand and remember instructions concerning participation.

Exclusion Criteria:

* Unable give informed consent.
* Unable to understand and follow instructions.
* Have abnormal tone or uncontrolled movements in the head-and-neck that would interfere with EEG recordings.
* Known to have photosensitive epilepsy.
* Open head lesions or sores.

Primary outcomes:
measure: Accuracy of a mu rhythm BCI using adaptation versus no adaptation.
timeFrame: 10 times over 5 weeks
Secondary outcomes:
Other outcomes:
Locations:
city: Ann Arbor
country: United States
facility: University of Michigan
state: Michigan
Study officials:
affiliation: University of Michigan
name: Jane Huggins, PhD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT06141759: The Effect of Conservative Treatment on Perceptual and Cognitive Asymmetry in Scoliosis
Official title: The Effect of Schroth Best Practice Exercises and Cheneau Brace Treatment on Perceptual and Cognitive Asymmetry in Adolescent Idiopathic Scoliosis With Thoracic Major Curve
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Adolescent Idiopathic Scoliosis
Lead sponsor: Bandırma Onyedi Eylül University
Sponsor class: OTHER
First posted: 2023-11-21
Enrollment: 30
Sex: ALL
Minimum age (years): 10
Maximum age (years): 16
Standard ages: CHILD
Accepts healthy volunteers: yes
Allocation: NON_RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: Adolescent idiopathic scoliosis (AIS) patients have been found to exhibit cortical asymmetry. This study aimed to examine the impact of conservative treatments on perceptual and cognitive asymmetry in the auditory system assessed by dichotic listening in AIS patients with thoracic major curves.

Detailed description: Background: Adolescent idiopathic scoliosis (AIS) patients have been found to exhibit cortical asymmetry. This study aimed to examine the impact of conservative treatments on perceptual and cognitive asymmetry in the auditory system assessed by dichotic listening in AIS patients with thoracic major curves. Method: This study involved 30 AIS patients and 21 healthy subjects. The intervention group used a Cheneau brace and performed 18 Schroth Best Practice (SBP) exercise sessions. Auditory lateralization was assessed using the Dichotic Listening Paradigm (DLP) in both groups before and after the intervention.

Eligibility criteria: Inclusion Criteria for Intervention Group:

* Having been diagnosed with AIS,
* Being 10-16 years of age,
* Having a Cobb angle of between 20° and 50°
* Risser's sign of 0-3,
* Having right thoracic scoliosis,
* Being right-handed,
* Having received no previous treatment that may affect scoliosis,
* Having no chronic disease requiring the use of medication.

Inclusion Criteria for Intervention Group:

* Participants aged 10-16 years

Exclusion Criteria for both groups:

* Having previous spinal operations,
* Hearing loss, or the presence of other muscular, neurological, or rheumatic diseases.

Primary outcomes:
measure: Dichotic Listening Paradigm
timeFrame: 6 weeks
Secondary outcomes:
Other outcomes:
Locations:
city: Balıkesir
country: Turkey
facility: Burçin Akçay
city: Balıkesir
country: Turkey
facility: Bandırma Onyedi Eylül University Faculty of Health Sciences Department of Physiotherapy and Rehabilitation
Study officials:
References:
Clinical trial NCT01062659: Cellular Immune Responses in the Liver in Chronic Hepatitis C (CHC) Patients
Official title: Characterization of Cellular Immune Responses in the Liver in Patients With Chronic Hepatitis C Virus Infection
Study type: OBSERVATIONAL
Overall status: WITHDRAWN
Conditions: Hepatitis C, Chronic
Liver Diseases
Virus Diseases
Keywords: HCV
hepatitis C virus
CHC
chronic hepatitis c
interferon
ribavirin
Hepatitis, Viral, Human
Anti-Infective Agents
peginterferon alfa-2a
peginterferon alfa-2b
Lead sponsor: University of Ulm
Sponsor class: OTHER
First posted: 2010-02-04
Enrollment: 0
Sex: ALL
Minimum age (years): 18
Maximum age (years): 65
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: All patient with established chronic hepatitis C presented to the liver unit of the outpatient clinic how are eligible to antiviral therapy.

Brief summary: In order to persist in the liver, HCV has numerous nonspecific and specific strategies to overcome the immunity of the host. The crucial step in the establishment of viral persistence and chronic hepatitis is the avoidance of specific antiviral cellular immune response in the liver. Treatment with pegylated interferon alpha (IFNα) in combination with ribavirin (RBV) is the standard therapy for chronic hepatitis C is. The response to IFNα / RBV therapy depends on the effective cellular antiviral immune response in the liver. The understanding of the interaction between HCV and cellular immune response is important for the effective use of existing diagnostic techniques, the Individual control and adjustment of the current therapeutic approaches and the development of future therapeutic and immunization strategies. In this study, the investigators want to investigate cellular Immune responses in the liver of HCV infected patients and characterize the influence of these immune responses to the response to IFNα / RBV therapy.


Eligibility criteria: Inclusion Criteria:

* proven chronic hepatitis C
* aged between 18 and 65
* willingness to give written informed consent to the study protocol

Exclusion Criteria:

* history of having received any IFN, PEG-IFN or RBV
* not eligible for antiviral treatment with peginterferon and ribavirin by standard of care

Primary outcomes:
Secondary outcomes:
Other outcomes:
Locations:
city: Ulm
country: Germany
facility: University Hospital Ulm
Study officials:
affiliation: University of Ulm
name: Dietmar M Klass, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT00614159: Ketamine Compared to Propofol for Pediatric GI Endoscopy
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Endoscopy
Keywords: Child age 1-10 years having a GI Endoscopy with sedation
Lead sponsor: State University of New York - Upstate Medical University
Sponsor class: OTHER
First posted: 2008-02-13
Enrollment: 34
Sex: ALL
Minimum age (years): 1
Maximum age (years): 10
Standard ages: CHILD
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: Pre-op setting, previously scheduled for GI Endoscopy

Brief summary: Elective outpatient endoscopy for children can be safely performed under general anesthesia with either propofol (1) or ketamine (2) infusions. Both infusions have an advantage over general anesthesia with volatile agents because they do not require intubation. The goal of both infusions is to have the patient breath spontaneously without reacting to the endoscopy which is a noxious stimulus. Patient movement, stridor and vomiting are can interrupt the procedure and increase overall OR time. Propofol also carries the added risk of causing apnea. This side effect is not commonly seen with Ketamine. Our hypothesis is that Ketamine's profile makes it a superior drug to Propofol for elective outpatient endoscopy because of reduced profound intra-operative interruptions and faster recovery time. We plan a study of pediatric patients ages 1 to 10 years old undergoing elective outpatient endoscopy. The patients will be randomized to receiving either a Ketamine or Propofol infusion, and the intra-operative interruptions will be documented by the anesthesiologist. The Post Anesthetic Care Unit (PACU) time to recovery will be monitored and recorded by a third party.


Eligibility criteria: Inclusion Criteria:

* Age 1-10
* Endoscopy with sedation scheduled

Exclusion Criteria:

* A history of chronic respiratory disease
* Upper respiratory infection
* Developmental delays
* Dysrhythmias
* Increased intercranial pressure
* Any sedatives or narcotics up to 6 weeks prior to procedure.

Primary outcomes:
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
References:
Clinical trial NCT04835259: Efficacy of Topical Antioxidants in Tretment of Photoaging
Official title: Efficacy of a Combination of Topical Antioxidants in Tretment of Photoaged Skin:A Randomized Controlled Trial
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Photoaging
Keywords: topical antioxidants
photoaged skin
Lead sponsor: Sohag University
Sponsor class: OTHER
First posted: 2021-04-08
Enrollment: 90
Sex: ALL
Minimum age (years): 30
Maximum age (years): 50
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: This randomized controlled trial study aims at investigating the efficacy and safety of topical antioxidants in treatment of a cohort of non-elderly volunteers with photoaged skin.

Detailed description: •Sample size calculation: The sample size was assessed prospectively using Openepi version 3.01 to provide a 80% power to detect a 40-50% difference before and after treatment using either topical antioxidants or retinoids with a significance level of 0.05 (based on the results of a previous clinical trial). Assuming 10% dropout, 30 patients will be recruited in each treatment group.

•Statistical analysis: Data will be collected and recorded on excel data sheet. Data will be tested for normality. Quantitative data will be represented as mean and standard deviation, or median and interquartile range. Qualitative data will be presented as number and percentage. The relevant statistical method will be used for comparison. P value will be considered statistically significant if it is less than 0.05

Eligibility criteria: Inclusion Criteria:

* Adult volunteers \< 50 years old
* Clinical and dermoscopic features of photoaging.

Exclusion Criteria:

* Genodermatoses associated with photosensitivity.
* Treatment by medications affecting skin aging (eg, topical and systemic retinoids) in the last 6 months prior to enrollment.
* Any recent cosmetic procedures.

Primary outcomes:
measure: change in Dermoscopy photoaging scale
timeFrame: assesed every month for 6 months
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
affiliation: Sohag University
name: esraa ismail
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT04534270: Efficacy and Safety of Dapagliflozin in Children With Proteinuria
Official title: Efficacy and Safety of Dapagliflozin in Non-diabetic Children With Proteinuria
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE4
Conditions: Proteinuria
Keywords: proteinuria
SGLT2i
Lead sponsor: Children's Hospital of Fudan University
Sponsor class: OTHER
First posted: 2020-09-01
Enrollment: 23
Sex: ALL
Minimum age (years): 6
Maximum age (years): 18
Standard ages: CHILD
ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: TREATMENT

Brief summary: The purpose of the study is to investigate the antiproteinuric effect of Dapagliflozin in children with proteinuria.


Eligibility criteria: Inclusion Criteria:

* Age 6 years to 18 years;
* Urinary protein excretion \> 0.2g in a 24-hr urine collection;
* eGFR≥60 ml/min/1.73m2;
* No history of diabetes;
* On stable doses of ACE inhibitors or angiotensin receptor blockers (ARBs) for \> 1 month;

Exclusion Criteria:

* Receiving immunosuppressive therapy within three months prior to enrolment.
* Blood pressure less than 5th percentile of the same gender, age, and height -
* Leukocyte and/or nitrite positive urinalysis that is untreated;
* History of organ transplantation, cancer, liver disease;
* Evidence of hepatic disease as determined by any one of the following: ALT or AST values exceeding 3x ULN at the screening visit;
* History of noncompliance to medical regimens or unwillingness to comply with the study protocol.

Primary outcomes:
measure: The change in 24-hr proteinuria after a 4 weeks treatment with dapagliflozin
timeFrame: From baseline to weeks 4
Secondary outcomes:
measure: The change in 24-hr proteinuria after a 12 weeks treatment with dapagliflozin
timeFrame: From baseline to weeks 12
measure: The change in eGFR after a 12 weeks treatment with dapagliflozin
timeFrame: Measured at baseline, weeks 4, weeks 8, weeks 12
Other outcomes:
Locations:
city: Shanghai
country: China
facility: Children's Hospital of Fudan University
state: Shanghai
Study officials:
References:
Clinical trial NCT02098070: Knee Pain Phenotypes in the Community Study
Official title: Knee Pain and Related Health in the Community Study
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Knee Osteoarthritis
Keywords: Knee Pain
Community Study
Knee Osteoarthritis
Risk Factors
Lead sponsor: University of Nottingham
Sponsor class: OTHER
Collaborators: name: Arthritis Research UK
First posted: 2014-03-27
Enrollment: 40000
Sex: ALL
Minimum age (years): 40
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: OTHER
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: Community-derived sample

Brief summary: The focus of the study is to determine the prevalence and variance of self-reported knee pain characteristics in a community-derived sample of adults aged 40 years and over. It will also identify characteristics such as structural changes of osteoarthritis of the knee as well as physiological parameters and blood and urine biomarkers.

Detailed description: Number of participants:

Part I: questionnaire to 40,000 people aged 40 years and over (giving an expected 10,000 respondents) Part II: 400 participants.

Eligibility criteria: Inclusion criteria:

* Aged 40 years and over

Exclusion criteria:

* Inability to give informed consent
* Terminal or mental illness
* Pregnant women

Primary outcomes:
measure: Knee Pain Phenotypes
timeFrame: up to 12 months
Secondary outcomes:
measure: Other Risk Factors
timeFrame: up to 12 months
Other outcomes:
Locations:
city: Nottingham
country: United Kingdom
facility: Academic Rheumatology
state: Nottinghamshire
Study officials:
affiliation: University of Nottingham
name: Michael Doherty, MD
role: PRINCIPAL_INVESTIGATOR
References:
citation: Swain S, Fernandes GS, Sarmanova A, Valdes AM, Walsh DA, Coupland C, Doherty M, Zhang W. Comorbidities and use of analgesics in people with knee pain: a study in the Nottingham Knee Pain and Health in the Community (KPIC) cohort. Rheumatol Adv Pract. 2022 Jun 15;6(2):rkac049. doi: 10.1093/rap/rkac049. eCollection 2022.
citation: Fernandes GS, Parekh SM, Moses J, Fuller CW, Scammell B, Batt ME, Zhang W, Doherty M. Depressive symptoms and the general health of retired professional footballers compared with the general population in the UK: a case-control study. BMJ Open. 2019 Sep 8;9(9):e030056. doi: 10.1136/bmjopen-2019-030056.
citation: Fernandes GS, Valdes AM, Walsh DA, Zhang W, Doherty M. Neuropathic-like knee pain and associated risk factors: a cross-sectional study in a UK community sample. Arthritis Res Ther. 2018 Sep 27;20(1):215. doi: 10.1186/s13075-018-1717-6.
citation: Fernandes GS, Sarmanova A, Warner S, Harvey H, Akin-Akinyosoye K, Richardson H, Frowd N, Marshall L, Stocks J, Hall M, Valdes AM, Walsh D, Zhang W, Doherty M. Knee pain and related health in the community study (KPIC): a cohort study protocol. BMC Musculoskelet Disord. 2017 Sep 21;18(1):404. doi: 10.1186/s12891-017-1761-4.
Clinical trial NCT00473070: A Clinical Study of Tobradex AF
Official title: A Clinical Study of Tobradex AF
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE3
Conditions: Cataract
Lead sponsor: Alcon Research
Sponsor class: INDUSTRY
First posted: 2007-05-14
Enrollment: 900
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The purpose of this study is to determine the amount of study medication that moves from the front of the eye into the fluid at the front of the inside of the eye.


Eligibility criteria: Inclusion Criteria:

* Adult patients requiring cataract surgery

Exclusion Criteria:

* Age related

Primary outcomes:
measure: Concentration of dexamethasone in aqueous humor following a single topical ocular administration
timeFrame: Periodic
Secondary outcomes:
measure: Changes in external and internal ocular structures, intraocular pressure, vision and other side effects
timeFrame: Periodic
Other outcomes:
Locations:
city: Pittsburgh
country: United States
facility: Pittsburgh
state: Pennsylvania
Study officials:
affiliation: Alcon Research
name: Robert Faulkner
role: STUDY_DIRECTOR
References:
Clinical trial NCT05978570: Physical Therapy in Pre-cystectomy Patients
Official title: Assessing the Impact of Physical Therapy in the Pre-cystectomy Pathway in Patients With Bladder Cancer on Patient Outcomes
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Bladder Cancer
Keywords: radical cystectomy
physical therapy
exercise program
Lead sponsor: UNC Lineberger Comprehensive Cancer Center
Sponsor class: OTHER
First posted: 2023-08-07
Enrollment: 68
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: CROSS_SECTIONAL
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Subjects who are with bladder cancer and receiving treatment at the study site.

Brief summary: This single-site, non-randomized, study evaluates the impact of a physical therapy consultation for patients with bladder cancer scheduled for radical cystectomy (RC). The purpose of this study is to investigate whether consultation with a physical therapist and the development of a personally tailored exercise program in the pre-cystectomy period for patients with bladder cancer will result in reduced post-operative complications, morbidity, length of inpatient stay, improve readmission 30-day and 90-day and improve 90-day mortality. This study will be partially retrospective (pre-implementation of a physical therapy consultation order) and partially prospective.


Eligibility criteria: In order to participate in this study a subject must meet all of the eligibility criteria outlined below:

Inclusion Criteria:

1. Age ≥ 18 years at the time of bladder cancer diagnosis
2. History of bladder cancer
3. Performance of radical cystectomy

Exclusion Criteria:

1. No history of bladder cancer or radical cystectomy

Primary outcomes:
measure: Thirty-day readmission rates
timeFrame: Up to 30 days after the date of cystectomy
Secondary outcomes:
measure: The proportion of individuals who received a physical therapy consultation
timeFrame: 1 day (the date of cystectomy)
measure: Ninety-day readmission rates
timeFrame: Up to 90 days after the date of cystectomy
measure: Acute care length of stay
timeFrame: Starting to the exercises to up to 90 days after the date of cystectomy
measure: Mortality rates
timeFrame: Up to 90 days after the date of cystectomy
measure: Post-cystectomy complication types and rates
timeFrame: Up to 90 days after the date of cystectomy
Other outcomes:
Locations:
city: Chapel Hill
country: United States
facility: Lineberger Comphrehensive Cancer Center at University of North Carolina at Chapel Hill
state: North Carolina
Study officials:
affiliation: Lineberger Comprehensive Cancer Center, The University of North Carolina Chapel Hill
name: Sasha Knowlton
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT03560570: Study of Hemostasis in Patients With Congenital Disorder of Glycosylation
Official title: Evaluation of Global Coagulation Balance of 57 Patients With Congenital Disorder of Glycosylation Using the Thrombin Generation Assay
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Congenital Disorders of Glycosylation
Keywords: stroke-like
thrombosis
haemorrhages
Lead sponsor: Assistance Publique - Hôpitaux de Paris
Sponsor class: OTHER
First posted: 2018-06-18
Enrollment: 57
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: CASE_CONTROL
Time perspective: RETROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: CDG cohort comes from reference center of rares metabolic diseases of Necker-Enfants malades hospital in Paris

Brief summary: The purpose of this study is to investigate the coagulation balance in a cohort of congenital disorder of glycosylation (CDG) patients using conventional tests combined with an integrated approach of their coagulation disorders in using TGA in the absence or presence of sTM. Thus, investigators aimed to define if the hemostatic balance in CDG patients, is preserved despite of combined deficiencies in both procoagulant and anticoagulant factors.

Detailed description: In CDG, coagulation abnormalities, affecting both pro and anticoagulant factors, could account for onset of acute microvascular events in these patients. In line with this hypothesis, a previous study reported a correlation between low activity of anticoagulant factors and thrombosis, although stroke-like episodes, the most frequent event, were not analyzed in this study. Moreover, the hemostatic balance is usually investigated by global coagulation tests such as the prothrombin time (PT) and the activated partial thromboplastin (aPTT). However, these tests have serious limitations. First, they explore only 5 % of the whole generated thrombin, enough to clot the plasma. In addition, global tests are insensitive to the coagulation inhibitors, especially the PC system which cannot be mobilized in the absence of thrombomodulin (TM). The thrombin generation assay (TGA), is also a global coagulation assay, but it allows exploration of the whole thrombin formation process from its generation to its inhibition. Moreover, combining different analytical conditions, all the anticoagulant systems could be investigated, including antithrombin in basal conditions and the PC system in the presence of soluble TM (sTM)

Eligibility criteria: Inclusion Criteria:

-Clinical diagnosis of Congenital Disorder of Glycosylation (CDG)

Exclusion Criteria:

- no exclusion criteria

Primary outcomes:
measure: Evaluation of haemostatic balance using thrombin generation assay
timeFrame: Up to 1 year
Secondary outcomes:
Other outcomes:
Locations:
city: Paris
country: France
facility: Hôpital Necker Enfants malades
Study officials:
affiliation: Assistance Publique - Hôpitaux de Paris
name: Delphine Borgel, PharmaD, PhD
role: PRINCIPAL_INVESTIGATOR
References: