Clinical trial NCT06309459: Carbonic Anhydrase IX Enzyme in Triple Negative Breast Carcinoma
Official title: Carbonic Anhydrase IX Enzyme in Triple Negative Breast Carcinoma: Relationship With Prognostic Factors and Response to Neoadjuvant Chemotherapy
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Triple Negative Breast Cancer
Carbonic Anhydrase IX
Keywords: Triple negative breast carcinoma
Carbonic anhydrase IX
Treatment effect
Ki67 proliferation index
Lead sponsor: Kahramanmaras Sutcu Imam University
Sponsor class: OTHER
First posted: 2024-03-13
Enrollment: 40
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: RETROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Triple Negative Breast Cancer cases who were operated in Elazığ Fethi Sekin SUAM

Brief summary: Triple-negative breast carcinoma is characterized by the absence of estrogen receptors, progesterone receptors, and HER2/neu receptors. Carbonic anhydrase IX (CA IX) is a tumor-associated cell surface glycoprotein that is involved in adaptation to hypoxia-induced acidosis and plays a role in cancer progression. This study aimed to investigate CA IX expression in TNBC and its relationship with treatment effect.

Detailed description: Tru-cut biopsy materials, sent to our hospital pathology laboratory between August 2018 and May 2023, will be examined. Invasive carcinoma cases will be evaluated according to estrogen, progesterone, and HER 2 receptor levels. Triple-negative tumor cases were isolated and those cases who underwent breast resection in our hospital after receiving neoadjuvant chemotherapy (Adriamycin, cyclophosphamide, and then paclitaxel for 4 cycles) were included in the study.

Eligibility criteria: Inclusion Criteria:

* Older than 18 years
* Triple-negative mastectomy cases
* Patients whose data can be available
* Patients who were operated in our hospital

Exclusion Criteria:

* Younger than 18 years
* Not triple negative mastectomy cases
* Patients with missing data
* Patients who were operated in another hospital

Primary outcomes:
measure: Poor prognostic factors in patients with TNBC
timeFrame: 2018-2023
measure: The treatment success with inhibiting the CA IX enzyme levels' effectiveness
timeFrame: 2018-2023
Secondary outcomes:
Other outcomes:
Locations:
city: Kahramanmaraş
country: Turkey
facility: Kahramanmaraş Sütçü İmam University
Study officials:
References:
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