Clinical trial NCT06849206: Pennington Generation Cohort
Official title: Pennington Generation Cohort
Study type: OBSERVATIONAL
Overall status: RECRUITING
Conditions: Obesity Prevention
Keywords: physical activity
obesity
diet
nutrition
families
Lead sponsor: Pennington Biomedical Research Center
Sponsor class: OTHER
First posted: 2025-02-27
Enrollment: 3000
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Adults of child-bearing age who are planning to become pregnant, expectant parents, as well as children, adolescents, and young adults and their nuclear family members will be recruited.

Brief summary: The Pennington Generation Cohort is an observational study comprised of Louisiana families. Families will be assessed at baseline for a variety of traits and behaviors, and then followed up over time to try to understand the role of lifestyle and the environment on the risk of developing obesity and other health outcomes.

Detailed description: Pennington Biomedical's Greaux Healthy initiative partners with communities to grow healthier generations by expanding the access and reach of Pennington Biomedical's evidence-based practices for the prevention and treatment of childhood obesity. As part of Greaux Healthy, the Pennington Generation Cohort will help evaluate the impact of the program. A sample of up to 1,500 children and adolescents and their families will be recruited from throughout Louisiana. An initial physical exam will establish a baseline for each family with respect to lifestyle behaviors, genetics, and body size/composition. This longitudinal cohort will also assess the association between participation in several childhood obesity prevention and treatment programs and subsequent obesity and related health outcomes. Members of the longitudinal cohort will be followed in the future through clinical visits, questionnaires, and through optional linkages to electronic medical records and administrative databases such as the National Death Index, Social Security Death Master File, and health registry data.

Eligibility criteria: Inclusion Criteria:

* Children, adolescents, and young adults (birth through age 24 years) and their nuclear family members\* and adults age 25+ who are expectant parents or are trying to conceive
* Self-reported resident of Louisiana
* Ability to understand instructions and complete all study procedures
* Able to provide informed consent (adults aged over 18 years)
* Able to provide assent (children 9 to 17 years)
* Able to communicate (oral and written) in English

Exclusion Criteria:

* Discretion of the Medical Monitor or Principal Investigator

Primary outcomes:
measure: Obesity
timeFrame: From enrollment up to 20 years of follow-up.
Secondary outcomes:
measure: Weight change
timeFrame: From enrollment up to 20 years of follow-up.
measure: Mortality
timeFrame: From enrollment up to 20 years of follow-up..
measure: Cancer incidence
timeFrame: From enrollment up to 20 years of follow-up..
Other outcomes:
Locations:
city: Baton Rouge
country: United States
facility: Pennington Biomedical Research Center
state: Louisiana
Study officials:
affiliation: Pennington Biomedical Research Center
name: Peter T Katzmarzyk, PhD
role: PRINCIPAL_INVESTIGATOR
References: