Clinical trial NCT04511858: Difference in Central Fatigue During Two Ultra-endurance Practices: Running vs. Cycling
Official title: Difference in Central Fatigue During Two Ultra-endurance Practices: Running vs. Cycling
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Ultra-marathon Runners
Keywords: central fatigue
peripheral fatigue
ultra-endurance exercise
corticospinal excitability
Lead sponsor: Centre Hospitalier Universitaire de Saint Etienne
Sponsor class: OTHER
First posted: 2020-08-13
Enrollment: 19
Sex: MALE
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: CROSSOVER
Intervention model description: Prospective study of physiopathology on subjects specializing in endurance and ultra-endurance: comparing running vs. cycling. Cross-over: each subject will carry out the 2 experimental conditions (running and cycling) according to a randomized order of passage, respecting a wash-out of 2 weeks.
Primary purpose: BASIC_SCIENCE

Brief summary: The mechanisms contributing to muscle fatigue in extreme long-duration exercise bouts are poorly understood. Ultra-endurance exercise is an excellent model for the study of adaptive responses to extreme loads and stress and it is an especially useful model for documenting the origins of central fatigue. This protocol will compare fatigue during and after ultra-endurance exercise bouts that result in moderate lower-limb tissue damage (i.e. cycling) or significant damage (i.e. running). The results of this protocol will allow us to further understanding of the reasons for major central fatigue, i.e. within the central nervous system, in ultra-endurance.


Eligibility criteria: Inclusion Criteria:

* Specialist in endurance and ultra-endurance. in the 2 disciplines: running and cycling (triathletes, duathletes or trailers achieving at least 30% of their training volume in cycling), and having at least finished one long distance event in the last 2 years,
* Affiliated or beneficiary of a social security scheme.
* Signature of the consent form

Exclusion Criteria:

* Any subject who has been injured in the 3 months prior to the protocol
* Anyone with chronic joint pathologies (e.g.: repetitive sprains, patellar or ligament problems).
* Any subject with chronic or central neurological pathologies
* Any subject with a contraindication to magnetic stimulation
* Use of neuro-active substances likely to alter cortico-spinal excitability (hypnotics, antiepileptics, psychotropic drugs, muscle relaxants) on the study.
* Contraindication to the application of a magnetic field:

  * Heart or respiratory insufficiency.
  * Subject with a cardiac pace maker.
  * Cardiac valve wear and serious cardiovascular diseases.
  * Presence of prosthetic material or ferromagnetic foreign bodies in the head.
  * Presence of cochlear implants or ocular prosthetic material.
  * History of neurosurgical interventions.
  * Neurological diseases that may affect brain structures and cognitive abilities (e.g., intracranial tumour, multiple sclerosis, history of stroke or traumatic brain injury).
  * History of comitiality, contralateral knee disease or musculoskeletal disease.
* Any subject participating at the same time in another interventional experiment requiring physical exercise.
* Any subject who has taken corticosteroids within 3 months (inhalation, infiltration or history of prolonged corticosteroid therapy).
* Any subject under guardianship or curatorship

Primary outcomes:
measure: Maximum level of voluntary activation of relative central fatigue
timeFrame: Before and immediately after 5h exercise
Secondary outcomes:
measure: Maximum level of voluntary activation of fatigue centrale absolute
timeFrame: Before and immediately after 5h exercise
measure: Maximum level of voluntary activation with electrical evoked activation
timeFrame: Before and immediately after 5h exercise
measure: Spinal excitability
timeFrame: Before and immediately after 5h exercise
measure: Corticospinal excitability
timeFrame: Before and immediately after 5h exercise
measure: Cortical excitability
timeFrame: Before and immediately after 5h exercise
measure: Measurement of isometric force values
timeFrame: Before and immediately after 5h exercise
measure: Measurement of speed, force and power values
timeFrame: Before and immediately after 5h exercise
measure: Red blood cells
timeFrame: Before and immediately after 5h exercise
measure: Platelets
timeFrame: Before and immediately after 5h exercise
measure: White blood cells
timeFrame: Before and immediately after 5h exercise
measure: Hemoglobin
timeFrame: Before and immediately after 5h exercise
measure: Mean corpuscular hemoglobin concentration
timeFrame: Before and immediately after 5h exercise
measure: C-reactive protein
timeFrame: Before and immediately after 5h exercise
measure: Creatine PhosphoKinase
timeFrame: Before and immediately after 5h exercise
measure: Interleukines
timeFrame: Before and immediately after 5h exercise
measure: Lactate
timeFrame: Before and immediately after 5h exercise
measure: Measurement of the time maintained at the speed corresponding to the 2nd ventilatory threshold
timeFrame: Before and immediately after 5h exercise
measure: measurement of the time maintained at the power corresponding to the 2nd ventilatory threshold
timeFrame: Before and immediately after 5h exercise
Other outcomes:
Locations:
city: Saint-Étienne
country: France
facility: CHU Saint-Etienne
Study officials:
affiliation: CHU SAINT-ETIENNE
name: Léonard FEASSON, MD PhD
role: PRINCIPAL_INVESTIGATOR
affiliation: SAINT-ETIENNE UNIVERSITY
name: Guillaume MILLET, PhD
role: STUDY_DIRECTOR
References: