Clinical trial NCT01876524: tRNS in Anterior Cingulate Cortex Reduces Craving Over Dual Pathology Patients
Official title: Transcranial Random Noise Stimulation in Anterior Cingulate Cortex Reduces Craving Over Dual Pathology Patients
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Substance Use Disorder
Attention Deficit Disorder With Hyperactivity
Bipolar Disorder
Schizophrenia
Personality Disorder
Keywords: Substance Use Disorder
Attention Deficit Disorder With Hyperactivity
Schizophrenia
Bipolar disorder
Personality disorder
Lead sponsor: Spanish Foundation for Neurometrics Development
Sponsor class: OTHER
Collaborators: name: Fundacion para la Formacion e Investigacion Sanitarias de la Region de Murcia
First posted: 2013-06-12
Enrollment: 225
Sex: ALL
Minimum age (years): 18
Maximum age (years): 60
Standard ages: ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The purpose of this study is to study the efficacy and security of noninvasive brain stimulation as a new approach for patients with Substance Use Disorders (SUDs) plus other psychiatric conditions like ADHD, Schizophrenia, Bipolar disorder, etc.

Detailed description: Background: There is an intimate relationship between addictive behaviors and other mental disorders, proven by clinical practice and many epidemiological studies, genetic and neuroscience. This gives risk to the diagnosis of Dual Pathology: an addiction and another mental disorder.

Functional neuroimaging studies have shown that anterior cingulate cortex is associated with substance´s dependence and craving. Transcranial random noise stimulation (tRNS) stimulates parts of the brain and can change it´s activity.

Researchers are interested in reduce cravings for substance dependence on patients with Dual Pathology using tRNS in anterior cingulate cortex.

Aims: To determine whether tRNS in anterior cingulate cortex can reduce craving over Dual Pathology patients.

Eligibility criteria: Inclusion Criteria:

* \> 18 years old and less than 60 years
* Best-practice diagnosed Dual Pathology
* Diagnosed since at least two years prior to enrollment.
* Abuse more than 2 Substances

ExclusionC riteria:

* Serious visual and hearing loss
* Brain injury following cranial trauma
* Other neurological disorders like Parkinson, ME, headache, etc.
* Birth trauma
* Mental retardation
* Pregnant

Primary outcomes:
measure: AMEN Questionnarie
timeFrame: Following patients during 3 months after Brain noninvasive estimulation
measure: Emotional Visual Event Related Potentials
timeFrame: Following patients during 3 months after Brain noninvasive estimulation
Secondary outcomes:
measure: CAGE Adapted to Include Drugs (CAGE-AID)
timeFrame: Following 3 months after tRNS brain stimulation
Other outcomes:
Locations:
city: Cartagena
country: Spain
facility: Slow Environment Foundation
state: Murcia
Study officials:
References:
citation: Soria Aledo V, Aguilar Domingo M, Garcia Cuadrado J, Carrasco Prats M, Gonzalez Martinez P. [Spontaneous rupture of the spleen: a rare form of onset of non-Hodgkin's lymphoma]. Rev Clin Esp. 1999 Aug;199(8):552-3. No abstract available. Spanish.