Clinical trial NCT03342339: Influence of Emotions on Decision-making in Parkinson's Disease
Official title: Influence of Emotions on Decision-making in Parkinson's Disease
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Parkinson Disease
Keywords: influence of emotions
positif emotional induction
decision making
Iowa Gambling Task
Lead sponsor: Centre Hospitalier Universitaire de Saint Etienne
Sponsor class: OTHER
First posted: 2017-11-14
Enrollment: 44
Sex: ALL
Minimum age (years): 50
Maximum age (years): 65
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: NON_RANDOMIZED
Intervention model: PARALLEL
Primary purpose: OTHER

Brief summary: Parkinson's disease mainly affects the dopaminergic neurons of the Substancia nigra, which project on the striatum. Neuronal death within this structure leads to a decrease in dopamine levels. Dopamine is a neurotransmitter essential to the proper functioning of the basal ganglia highly involved in the control of voluntary and involuntary movements.

It also leads to cognitive and behavioral changes. Among these changes, the investigators will mainly remember the idea of the emergence of difficulties to make the right decisions, for example at the financial, medical .... This disruption would be the result of executive dysfunction. By definition, executive functions allow us to evaluate, plan and organize our actions to achieve a goal.

Detailed description: Some research shows that positive emotional states are associated with greater self-confidence, greater optimism, and better regulation of our decision-making. The goal is to test whether positive emotional induction could improve decision-making in Parkinson's disease.

Listening to music would decrease anxiety levels and increase self-esteem levels. Who says Parkinson says dopamine deficiency and so the investigators can think that the investigators can help patients by inducing a positive emotion through musical stimulation.

All participants will be subject to emotional induction. They will be divided into two different conditions: either they will be induced in a positive state, or they will be maintained in a neutral state. For this, video clips (positive or neutral) containing music will be presented. Immediately after the presentation of the video, participants will have to perform the Iowa Gambling Task test. This is a sequential task to evaluate decision-making capabilities.

Eligibility criteria: Inclusion Criteria for patients :

* Diagnosis of the disease carried out by a hospital doctor
* Stable treatment for two months minimum.
* Mini-Mental Parkinson \> 26
* Under dopaminergic treatment

Exclusion Criteria for patients :

* other neurological or psychiatric antecedents
* anxio-depressive symptomatology
* delusional or psychotic state

Inclusion Criteria for witnesses :

* matched in age and sex
* Vision and hearing normal or successfully corrected
* Understand the French language
* general level in the test standard

Exclusion Criteria for witnesses :

* neurological or psychiatric diseases
* anxio-depressive symptomatology

Primary outcomes:
measure: net score of Iowa Gambling Task Test
timeFrame: day 1
Secondary outcomes:
Other outcomes:
Locations:
city: Grenoble
country: France
facility: CHU de Grenoble Alpes
city: Saint-Étienne
country: France
facility: CHU de Saint Etienne
Study officials:
References: