louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT06083285: Impact of the CRRT Management Protocol on Prognostic Outcome in Patients With Septic Acute Kidney Injury
Official title: Xinjiang Medical University of Affiliated Tumour Hospital
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: To Explore the Influence of CRRT Nursing Team Management Plan on the Prognosis of SAKI Patients
Lead sponsor: Xinjiang Medical University
Sponsor class: OTHER
First posted: 2023-10-13
Enrollment: 76
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: RETROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: 36 SAKI patients who were treated with CRRT in ICU of our hospital from February 2021 to August 2021 were set as the control group, and the routine bedside CRRT nursing management process was implemented in this stage; In addition, from September 2021 to March 2022, 40 SAKI patients who received CRRT treatment in our ICU were set as the observation group.The management plan of CRRT special nursing team was implemented to compare the incidence of non planned removal of CRRT, unplanned extubation and CRRT nursing related complications between the two groups, as well as the difference of coagulation function indexes before and 3 days after nursing.

Brief summary: The implementation of CRRT nursing team management program in the treatment of SAKI can significantly reduce the incidence of adverse events and complications in CRRT nursing, which has a positive role in improving the success rate of CRRT treatment and the clinical outcome of patients.


Eligibility criteria: Inclusion Criteria:

* The Guidelines for Emergency Treatment of Sepsis / Septic Shock in China (2018)\[4\]Diagnostic criteria for moderate sepsis; ② meets the Organization for Improving Global Kidney Disease Outcomes (KDIGO) Clinical Practice Guidelines: AKI\[5\]Relevant diagnostic criteria in; ③ received CRRT as indicated for CRRT; ④ in ICU for longer than 24 hours; ⑤ signed consent.

Exclusion Criteria:

* with chronic organ failure, or advanced malignancy; ② with previous history of chronic kidney disease, retrorenal urinary tract obstruction; ③ with incomplete clinical data.

Primary outcomes:
measure: To explore the influence of CRRT nursing team management plan on the prognosis of SAKI patients.
timeFrame: 3-10 days
Secondary outcomes:
Other outcomes:
Locations:
city: Urumqi
country: China
facility: Xinjiang Medical University of Affiliated tumour Hospital
state: Xinjiang
Study officials:
References:
Clinical trial NCT06622785: Physical Activity of Participants in Different Age Groups
Official title: Examination of the Perceptions of Benefits and Obstacles Related to Physical Activity of Participants in Different Age Groups
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Adults 18 Years and Older (no Other Exclusion Criteria)
Keywords: healthy
people
physical activity
age
Lead sponsor: Nigde Omer Halisdemir University
Sponsor class: OTHER
Collaborators: name: Ankara Yildirim Beyazıt University
First posted: 2024-10-02
Enrollment: 330
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: OTHER
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Healty people

Brief summary: The subject of the research is to determine the physical activity levels of the participants in different age categories and to determine and analyse participants' perceptions of the benefits of physical activity and the factors that prevent from doing physical activity.

Detailed description: The subject of the research is to determine the physical activity levels of the participants in different age categories and to determine and analyse participants' perceptions of the benefits of physical activity and the factors that prevent from doing physical activity. In this study, it is aimed to determine the physical activity levels of individuals in different age categories and to determine the barriers and benefit perceptions of physical activity.

Eligibility criteria: Inclusion Criteria:

* Being over 18 years old

Exclusion Criteria:

* Not volunteering for research
* Those with incomplete evaluation forms

Primary outcomes:
measure: Descriptive assessment
timeFrame: Baseline
measure: Exercise benefits and barriers
timeFrame: baseline
measure: Physical activity
timeFrame: baseline
Secondary outcomes:
Other outcomes:
Locations:
city: Niğde
country: Turkey
facility: Niğde Ömer Halisdemir University
state: Bor
Study officials:
affiliation: Niğde Ömer Halisdemir University
name: Gürkan Demirtaş, Msc
role: PRINCIPAL_INVESTIGATOR
affiliation: Ankara Yildirim Beyazıt University
name: Arife Akbulut Bayrak, Msc
role: PRINCIPAL_INVESTIGATOR
affiliation: Gazi University
name: Havva Sümeyye Eroğlu, Msc
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT06718985: Impact of Bone Mineral Density on Fracture Risk Assessment in RA
Official title: Does Incorporating Bone Mineral Density Change Fracture Risk Assessment and Influence Treatment Decisions in Rheumatoid Arthritis Patients?
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Rheumatoid Arthritis
Lead sponsor: Istanbul Physical Medicine Rehabilitation Training and Research Hospital
Sponsor class: OTHER_GOV
First posted: 2024-12-05
Enrollment: 60
Sex: ALL
Minimum age (years): 40
Maximum age (years): 90
Standard ages: ADULT
OLDER_ADULT
Observational model: CASE_ONLY
Time perspective: CROSS_SECTIONAL
Sampling method: PROBABILITY_SAMPLE
Study population: Rheumatoid arthritis patients

Brief summary: This study investigates whether incorporating bone mineral density (BMD) into FRAX calculations changes fracture risk assessment and influences treatment decisions in rheumatoid arthritis (RA) patients. Analyzing 60 RA patients, FRAX scores for 10-year major osteoporotic and hip fractures were calculated with and without BMD. While no significant differences were found between the two methods, discrepancies in treatment recommendations were identified, particularly for hip fractures. The findings emphasize the importance of combining BMD and FRAX for a more comprehensive fracture risk assessment and informed treatment decision-making in RA patients.


Eligibility criteria: Inclusion Criteria:

* Diagnosis of rheumatoid arthritis (RA) based on ACR/EULAR criteria.
* Age between 40-90 years.
* Dual-energy X-ray absorptiometry (DXA) results obtained within the past six months.
* Availability of complete clinical and demographic data for fracture risk assessment.
* Patients who provide informed consent for the study.

Exclusion Criteria:

* Patients with secondary causes of osteoporosis (e.g., hyperparathyroidism, Cushing's syndrome).
* Use of medications affecting bone metabolism (e.g., glucocorticoids \>7.5 mg/day, bisphosphonates, denosumab) within the past year.
* History of metabolic bone diseases other than osteoporosis (e.g., osteomalacia, Paget's disease).
* Patients with a history of malignancy, except for non-melanoma skin cancer.
* Incomplete or missing data required for FRAX or DXA analysis.
* Any condition or comorbidity likely to affect fracture risk assessment, as determined by the clinician.

Primary outcomes:
measure: Concordance Between FRAX Scores With and Without BMD
timeFrame: 0 day
Secondary outcomes:
measure: Treatment Threshold Exceedance Based on FRAX Calculations
timeFrame: 0 day
Other outcomes:
Locations:
city: Istanbul
country: Turkey
facility: Istanbul Physical Medicine and Rehabilitation Training and Research Hospital
state: Bahcelievler
Study officials:
References:
Clinical trial NCT01919385: Feasibility Study Assessing the Ability of an Insulin Pump-controlling Algorithm to Minimize Hypoglycemia
Official title: Feasibility Study Assessing the Ability of an Insulin Pump-controlling Algorithm to Minimize Hypoglycemia in Patients With Type 1 Diabetes in a Clinical Research Setting
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE1
Conditions: Type 1 Diabetes
Keywords: Type 1 diabetes
Insulin Pump
Lead sponsor: Animas Corporation
Sponsor class: INDUSTRY
First posted: 2013-08-09
Enrollment: 12
Sex: ALL
Minimum age (years): 21
Maximum age (years): 65
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: BASIC_SCIENCE

Brief summary: This study will be conducted in a Clinical Research Center (CRC) setting and recruiting type 1 diabetes that are currently using an insulin pump.

Detailed description: This study is a non-randomized, uncontrolled feasibility study that looks to enroll people with type 1 diabetes who are currently using an insulin pump. During the subject's participation, the study staff will closely monitor the study subject in a clinical research center environment for approximately 30 hours, while controller algorithm determined insulin doses are delivered by an insulin pump, and utilizing continuous glucose monitoring results.

Eligibility criteria: Inclusion Criteria:

* Age 21-65 years
* Type 1 diabetes mellitus for at least one year
* Currently using an insulin infusion pump for at least the past 6 months

Exclusion Criteria:

* Pregnancy
* History of Diabetic Ketoacidosis (DKA) in the past six months
* History of severe hypoglycemia (Seizure, unconsciousness) in the past 6 months

Primary outcomes:
measure: Evaluate the performance of the System while the subject is under close medical supervision in the Clinical Research Center (CRC) setting
timeFrame: 1 week after subject is enrolled in the study
Secondary outcomes:
measure: Capturing the number of Adverse Events as a measure of assessing subject safety
timeFrame: 1 week after subject is enrolled in the study
Other outcomes:
Locations:
city: Santa Barbara
country: United States
facility: Samsum Diabetes Reserach Inst.
state: California
Study officials:
affiliation: Samsum Diabetes Reserach Inst.
name: Howard Zisser, MD
role: PRINCIPAL_INVESTIGATOR
References:
citation: Finan DA, Dassau E, Breton MD, Patek SD, McCann TW Jr, Kovatchev BP, Doyle FJ 3rd, Levy BL, Venugopalan R. Sensitivity of the Predictive Hypoglycemia Minimizer System to the Algorithm Aggressiveness Factor. J Diabetes Sci Technol. 2015 Jun 30;10(1):104-10. doi: 10.1177/1932296815593292.
Clinical trial NCT02790385: Negative Pressure Wound Therapy - A Multi-Centered Randomized Control Trial
Official title: Use of Incisional Negative Pressure Wound Dressing Versus Standard Dry Gauze Dressing for Wound Closure in Patients Undergoing Spinal Surgery - A Multicentre Randomized Control Trial
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: EARLY_PHASE1
Conditions: to See Whether Negative Pressure Wound Therapy Decreases Wound Infections.
Lead sponsor: University of British Columbia
Sponsor class: OTHER
First posted: 2016-06-03
Enrollment: 870
Sex: ALL
Minimum age (years): 8
Maximum age (years): 21
Standard ages: CHILD
ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: PREVENTION

Brief summary: Children with neuromuscular disorders such as cerebral palsy, children with kyphosis and post-traumatic scoliosis have higher infection rates after scoliosis surgery than healthy children who undergo scoliosis surgery. The purpose of our study is to compare the effect of NPWT on infection rates when compared to standard gauze dressing. Participants will be randomized to the "NPWT" or "standard dressing" group. We will compare infection rates between the two groups. We hypothesize participants in the "NPWT" group will have a lower infection rate.


Eligibility criteria: Inclusion Criteria:

* Male or female
* Consent/assent to participate in the study
* Undergoing posterior spinal surgery categorized as High-Risk for infection, defined as greater than 4% risk of deep or superficial infection based previous reported literature. Procedures qualifying for study are listed below:
* Kyphosis (any type)
* Posttraumatic Scoliosis
* Neuromuscular Scoliosis

Exclusion Criteria:

* Previous incisions over the operative site
* History of keloid formation
* Allergy to tape
* Does not consent/assent to participate in the study
* Previous or Active Spinal infection
* Dural tear
* Hemophiliac
* Two Stage procedure
* Unable to follow standard antibiotic protocols

Primary outcomes:
measure: Wound Infection
timeFrame: up to post op day 14
Secondary outcomes:
measure: Time for wound closure
timeFrame: intraoperatively
measure: Cosmetic results
timeFrame: 12 weeks post op
measure: Caregiver/parental satisfaction
timeFrame: 12 weeks post op
measure: Wound dehiscence
timeFrame: psot op day 5 to discharge
measure: Foreign body reaction
timeFrame: 12 weeks post op
Other outcomes:
Locations:
city: Vancouver
country: Canada
facility: BC Children's Hospital
state: British Columbia
Study officials:
References:
Clinical trial NCT04558385: Seroconversion in COVID-19 Recovered Population
Official title: Seroconversion in COVID-19 Recovered Population: an Observational Study
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Covid19
Lead sponsor: Lahore General Hospital
Sponsor class: OTHER_GOV
First posted: 2020-09-22
Enrollment: 275
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: CASE_ONLY
Time perspective: RETROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: population who have suffered from COVID 19, whose disease was either confirmed by PCR or clinically and then recovered

Brief summary: This study investigate the kinetics of IgG responses to both N and S proteins in the subjects who suffered from COVID 19 and then had recovered.

Detailed description: Coronaviruses (CoVs) are enveloped, single positive-strand RNA viruses belonging to the large subfamily Coronavirinae, which can infect mammals and several other animals.The continued spread of coronavirus disease 2019 (COVID-19) has prompted widespread concern around the world, and the World Health Organization (WHO), on 11 March 2020, declared COVID-19 a pandemic. Studies on severe acute respiratory syndrome (SARS) and Middle East respiratory syndrome (MERS) showed that virus-specific antibodies were detectable in 80-100% of patients at 2 weeks after symptom onset. Currently, the antibody responses against SARS-CoV-2 remain poorly understood and the clinical utility of serological testing is unclear Little is known about the kinetics, tissue distribution, cross-reactivity and neutralization antibody response in COVID-19 patients .

The seropositivity rate of both IgM and IgG responses after onset and recovery of disease, and in the context of both N protein and S protein has not been clarified. The kinetics of antibody responses in critical cases or ICU patients has not been reported, and no studies have suggested whether antibody response is associated with disease prognosis

Eligibility criteria: Inclusion Criteria:

Subjects recovered from COVID 19 confirmed on PCR or clinically

Exclusion Criteria:

subjects who have not been confirmed suffering from COVID 19 by PCR or clinically

Primary outcomes:
measure: IgG SARS CoV2
timeFrame: 5 months
Secondary outcomes:
Other outcomes:
Locations:
city: Lahore
country: Pakistan
facility: Lahore General Hospital
state: Punjab
Study officials:
affiliation: LahoreGeneralHospital.Lahore
name: Amina Asif, MPhilMicro
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT01522885: KatGuide Method Versus Conventional Method at Insertion of Chest Tube
Official title: KatGuide-trial. KatGuide Method Versus Conventional Method at Insertion of Chest Tube. A Randomized, Parallel Group, Controlled Trial.
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE3
Conditions: Pneumothorax
Hydrothorax
Hemothorax
Empyema
Chylothorax
Keywords: Chest tube
placement
mal positioning
Lead sponsor: University of Aarhus
Sponsor class: OTHER
Collaborators: name: University of Aarhus
First posted: 2012-02-01
Enrollment: 109
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The purpose of this study is to investigate whether if KatGuide (a new developed medical device) improves the placing of a large bore chest tube in the pleural cavity compared to the conventional method.


Eligibility criteria: Inclusion Criteria:

* Patients with pneumothorax in the upper pleural space or fluid in the lower pleural space.
* Indication for upper or lower placement of a single chest tube in the pleural cavity
* 18 years of age or older

Exclusion Criteria:

* Fertile women
* Patients who can not give written or verbal consent to participate
* If there is no time or possibility to inform the patient
* Patients who already has a large bore chest tube
* Patients with long lasting (\>14 days) or chronic chest tube
* Patients with both fluid and air in the pleural cavity
* Patients where "the safe area" (front axillary fold, IC 4-5) can not be used for chest tube insertion

Primary outcomes:
measure: Chest tube placement
timeFrame: 3 hours
Secondary outcomes:
measure: Length of hospital stay
timeFrame: 5 days
measure: Time with chest tube
timeFrame: 3 days (mean time)
measure: Infection in wound
timeFrame: 4 weeks
measure: Number of chest tubes
timeFrame: 7 days (mean time)
Other outcomes:
Locations:
city: Aarhus
country: Denmark
facility: Niels Katballe
state: Aarhus N
city: Aalborg
country: Denmark
facility: Vytautas Nekrasas
city: Aarhus N
country: Denmark
facility: Niels Katballe
city: Odense
country: Denmark
facility: Peter B Licht
Study officials:
affiliation: University of Aarhus
name: Niels Katballe, MD, PhD
role: STUDY_DIRECTOR
References:
citation: Katballe N, Moeller LB, Olesen WH, Litzer MM, Andersen G, Nekrasas V, Licht PB, Bach P, Pilegaard HK. A Novel Device for Accurate Chest Tube Insertion: A Randomized Controlled Trial. Ann Thorac Surg. 2016 Feb;101(2):527-32. doi: 10.1016/j.athoracsur.2015.07.017. Epub 2015 Sep 26.
Clinical trial NCT04389437: OCT-Angiography and Adaptive Optics in Patients With Memory Impairment
Official title: OCT-Angiography and Adaptive Optics in Patients With Memory Impairment
Study type: INTERVENTIONAL
Overall status: RECRUITING
Phase: NA
Conditions: Amnesia
Alzheimer Disease
Lewy Body Disease
Parkinsons Disease With Dementia
Keywords: OCT-A
adaptative optics
Lead sponsor: Fondation Ophtalmologique Adolphe de Rothschild
Sponsor class: NETWORK
First posted: 2020-05-15
Enrollment: 450
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: NON_RANDOMIZED
Intervention model: PARALLEL
Primary purpose: DIAGNOSTIC

Brief summary: Studies suggest an association between retinal abnormalities and NCD (Neuro Cognitive Disorders) whether they are linked to proven or prodromal Alzheimer's disease (aMCI : amnestic mild cognitive impairment), or to other neurodegenerative diseases such as frontotemporal dementia or Lewy body diseases.

These retinal anomalies objectified by OCT-A (Optical coherence tomography angiography) and adaptive optics (AO) appear different depending on the pathologies and could therefore serve as markers in vivo of the pathophysiological processes underlying NCD.

No study to date has studied the retina and its vessels in NCD using adaptive optics. In this pilot study, we are proposing a combination of two new ophthalmological imaging techniques (OCT-A and AO), which allow rapid in vivo analysis in a completely non-invasive way of the morphology of small vessels as well as architecture of the retina to better specify the retinal anomalies associated with NCD. We will compare the parameters in OCT-A and AO between patients with NCD and controls without NCD (with memory complaint or without) and will seek to determine if there are different profiles according to the causes of NCD.


Eligibility criteria: Inclusion Criteria:

* Patient presenting in memory consultation for memory complaint or person accompanying a patient in memory consultation for memory complaint

Exclusion Criteria:

* pregnant or lactating women
* history of known non-degenerative neurological pathology (tumor, stroke territorial, in particular multiple sclerosis)
* history of retinal pathology
* ametropia greater in absolute value than 3 diopters on the sphere, or/and 1.5 diopters on the cylinder.
* history of taking ethambutol for more than 2 months
* history of takingsynthetic antimalarial for more than 2 years
* Mini Mental State Score (MMS) and / or Montreal Cognitive Assessment (MoCA) \<10 for patients and 26 for accompanying persons
* MRI contraindication (for patients only)

Primary outcomes:
measure: Wall to lumen ratio (WLR)
timeFrame: Baseline (Inclusion)
Secondary outcomes:
Other outcomes:
Locations:
city: Paris
country: France
facility: Hôpital Fondation A. de Rothschild
Study officials:
affiliation: Fondation A. de Rothschild
name: Antoine MOULIGNIER, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT01980537: Stereotaxis and Chronic Total Occlusion
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Chronic Total Coronary Occlusion
Lead sponsor: Medical University of Vienna
Sponsor class: OTHER
First posted: 2013-11-11
Enrollment: 40
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: Wire-crossing of a chronic total coronary occlusion (CTO) is time-consuming and limited by the amount of contrast agent and time of radiation exposure. Magnetic wire navigation might accelerate wire-crossing by maintaining a coaxial vessel orientation. This study compares magnetic with conventional wire navigation for recanalization of CTOs.


Eligibility criteria: Inclusion Criteria:

* symptomatic
* preserved wall motion or viable myocardium
* chronic total occlusion

Exclusion Criteria:

* chronic renal failure
* prior allergic reactions against contrast agent
* hyperthyreosis
* claustrophobia
* pregnancy
* contraindications to aspirin or clopidogrel

Primary outcomes:
measure: level of contrast medium
timeFrame: 8 hours
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
References: