Clinical trial NCT05131048: Home Based Hip Strengthening for Knee OA Patients
Official title: Effects of Home-based Hip Strengthening Exercises on Pain, Range of Motion and Functional Disability in Knee Osteoarthritis Patients: a Randomized Controlled Trial
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Knee Osteoarthritis
Keywords: osteoarthritis
home-based exercise plan
functional disability
obesity
Lead sponsor: University of Lahore
Sponsor class: OTHER
First posted: 2021-11-23
Enrollment: 90
Sex: ALL
Minimum age (years): 40
Maximum age (years): 60
Standard ages: ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: In knee osteoarthritis patients, weakness of hip abductor muscles is considered an important contributing factor leading to the progression of the disease.

Detailed description: Osteoarthritis is the most common type of disease that results from an abnormality in joint function. Osteoarthritis(OA) is a condition that is characterized by progressive loss of articular cartilage of a joint and causes pain. Yamda et al. found that the strength of hip adductors increases with the severity of the disease. This reflects that more use of these muscles lower knee adductor moment 54. Considering this research, knee loads can be altered by strengthening hip muscles. Pakistan is listed in 3rd world countries and the poverty index is high. Many patients show reluctance in going to clinics for the physiotherapeutic management of knee OA. So, the present research intends to investigate the effects of home-based hip strengthening exercise on pain, functions, and range of motion in elderly knee osteoarthritis patients.

Eligibility criteria: Inclusion Criteria:

* The age group was from 40 to 60 years.
* Both males and females were included.
* Average knee pain on walking \>3 on an 11-point scale (NPRS) (0 no pain; 10 maximal pain).
* participants can walk independently without any assistive devices
* Diagnosed patients of grade II \& III of Kallgren and Lawrence scale for knee osteoarthritis referred by an orthopaedic surgeon

Exclusion Criteria:

* History of osteoporosis.
* Leg length discrepancy or structural deformity
* Knee surgery or TKR.
* Corticosteroid injection in knee joint
* Systemic arthritic condition
* History of tibiofemoral and patellofemoral replacement
* Any other neurological and muscular condition affecting the lower limb
* Any history of radiculopathy.

Primary outcomes:
measure: intensity of Pain
timeFrame: baseline data
measure: intensity of Pain
timeFrame: at the end of 6th week
measure: Range of Motion
timeFrame: baseline data
measure: Range of Motion
timeFrame: at the end of 6th week
measure: Functional Disability
timeFrame: baseline data
measure: Functional Disability
timeFrame: at the end of 6th week
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
affiliation: The University of Lahore
name: faizan asghar
role: PRINCIPAL_INVESTIGATOR
References:
citation: Valdes AM, McWilliams D, Arden NK, Doherty SA, Wheeler M, Muir KR, Zhang W, Cooper C, Maciewicz RA, Doherty M. Involvement of different risk factors in clinically severe large joint osteoarthritis according to the presence of hand interphalangeal nodes. Arthritis Rheum. 2010 Sep;62(9):2688-95. doi: 10.1002/art.27574.
citation: Blagojevic M, Jinks C, Jeffery A, Jordan KP. Risk factors for onset of osteoarthritis of the knee in older adults: a systematic review and meta-analysis. Osteoarthritis Cartilage. 2010 Jan;18(1):24-33. doi: 10.1016/j.joca.2009.08.010. Epub 2009 Sep 2.
citation: Fatima S, Arslan SA, Sharif F, Ahmad A, Gillani SA, Zaheer A. Translation, cross-cultural adaptation and psychometric properties of the Urdu version of knee injury and osteoarthritis outcome score questionnaire for Pakistani population. BMC Musculoskelet Disord. 2021 Jun 26;22(1):592. doi: 10.1186/s12891-021-04477-1.
citation: Bhatia D, Bejarano T, Novo M. Current interventions in the management of knee osteoarthritis. J Pharm Bioallied Sci. 2013 Jan;5(1):30-8. doi: 10.4103/0975-7406.106561.
citation: Farrokhi S, Voycheck CA, Tashman S, Fitzgerald GK. A biomechanical perspective on physical therapy management of knee osteoarthritis. J Orthop Sports Phys Ther. 2013 Sep;43(9):600-19. doi: 10.2519/jospt.2013.4121.
citation: Safran-Norton CE, Sullivan JK, Irrgang JJ, Kerman HM, Bennell KL, Calabrese G, Dechaves L, Deluca B, Gil AB, Kale M, Luc-Harkey B, Selzer F, Sople D, Tonsoline P, Losina E, Katz JN. A consensus-based process identifying physical therapy and exercise treatments for patients with degenerative meniscal tears and knee OA: the TeMPO physical therapy interventions and home exercise program. BMC Musculoskelet Disord. 2019 Nov 4;20(1):514. doi: 10.1186/s12891-019-2872-x.
citation: Arhos EK, Thoma LM, Grindem H, Logerstedt D, Risberg MA, Snyder-Mackler L. Association of Quadriceps Strength Symmetry and Surgical Status With Clinical Osteoarthritis Five Years After Anterior Cruciate Ligament Rupture. Arthritis Care Res (Hoboken). 2022 Mar;74(3):386-391. doi: 10.1002/acr.24479. Epub 2022 Jan 19.