Clinical trial NCT00005485: The Jackson Heart Study of Cardiovascular Disease Among African Americans
Official title: The Jackson Heart Study of Cardiovascular Disease Among African Americans
Study type: OBSERVATIONAL
Overall status: ENROLLING_BY_INVITATION
Conditions: Cardiovascular Diseases
Heart Diseases
Atherosclerosis
Coronary Disease
Hypertension
Cerebrovascular Disorders
Keywords: Cardiovascular diseases
Heart failure
Stroke
Coronary heart disease
Diabetes
Hypertension
Chronic kidney disease
Lead sponsor: National Heart, Lung, and Blood Institute (NHLBI)
Sponsor class: NIH
Collaborators: name: National Institute on Minority Health and Health Disparities (NIMHD)
First posted: 2000-05-26
Enrollment: 3000
Sex: ALL
Minimum age (years): 35
Maximum age (years): 84
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: African-American men and women residents of metropolitan Jackson, Mississippi

Brief summary: This is a prospective study of the environmental and genetic factors that influence the development of cardiovascular disease (CVD) in African American men and women. The cohort is a collaboration among multiple institutions (Jackson State University, Mississippi State Department of Health, Tougaloo College, and the University of Mississippi Medical Center), the National Institute on Minority Health and Health Disparities (NIMHD), and the National Heart, Lung, and Blood Institute (NHLBI).

Detailed description: The Jackson Heart Study (JHS) initiated in 1998, is a longitudinal investigation of genetic and environmental risk factors associated with the disproportionate burden of cardiovascular disease (CVD) in African Americans. In addition, the JHS conducts community education and outreach activities to promote healthy lifestyles and reduce disease risk burden, undergraduate- and graduate-level research training programs, and high school science and math enrichment programs to prepare and encourage students from underrepresented racial/ethnic groups to pursue biomedical careers. The study recruited 5306 African-American residents living in the Jackson, MS, metropolitan statistical area of Hinds, Madison, and Rankin Counties. Participants were enrolled from each of 4 recruitment pools: random, 17%; volunteer, 30%; currently enrolled in the Atherosclerosis Risk in Communities (ARIC) Study, 31% (shared JHS/ARIC cohort); and secondary family members, 22%. Recruitment was limited to non-institutionalized adult African Americans aged 35-84 years, except in a nested family cohort where those 21 to 34 years of age were also eligible. The final cohort included 6.59% of all African American residents in the Jackson MSA aged 35-84 during the baseline exam (N=76,426, US Census 2000). Among these, approximately 3,700 gave consent that allows genetic research and deposition of data into dbGaP. JHS participants have completed three clinical examinations (Exam 1, 2000-04; Exam 2, 2005-08; and Exam 3, 2009-13) that have generated extensive longitudinal data on traditional and putative CVD risk factors, socioeconomic and sociocultural factors, biochemical analytes, and measures of subclinical disease from echocardiography, cardiac magnetic resonance imaging (MRI), and computed tomography (CT) scans of the heart, aorta, and abdomen. Stored biological samples have been assayed for putative biochemical risk factors and stored for future research. DNA has been extracted and lymphocytes cryopreserved for study of candidate genes, genome-wide scanning, expression, and other -omics investigations. Participants have been contacted annually to update information, confirm vital status, document interim medical events, hospitalizations, and functional status, and obtain additional sociocultural information. Ongoing cohort surveillance includes abstraction of medical records and death certificates for relevant International Classification of Diseases (ICD) codes and adjudication of nonfatal events and deaths. The JHS serves as a resource to the scientific community for novel research, promotes cardiovascular health in the local community, and encourages underrepresented minority students to pursue biomedical careers.

Exam 4 began in 2020 and is ongoing. Data collection for the current exam includes anthropometrics, blood pressure, urine and blood samples, echocardiogram, electrocardiogram, neurocognitive battery, physical function, interviews, and brain MRI.

Eligibility criteria: Inclusion Criteria:

* African American
* Residents of Jackson, Mississippi

Exclusion Criteria:

* Institutionalization

Primary outcomes:
measure: Cardiovascular Disease
timeFrame: 2000-2016
Secondary outcomes:
measure: Mortality
timeFrame: 2000-2018
Other outcomes:
Locations:
city: Jackson
country: United States
facility: UMMC, JSU, Tougaloo College, MSDH
state: Mississippi
Study officials:
affiliation: Tougaloo College JHS UTEC
name: Wendy White, PhD
role: PRINCIPAL_INVESTIGATOR
affiliation: Jackson State University JHS GTEC
name: Marinelle Payton, MD, PhD
role: PRINCIPAL_INVESTIGATOR
affiliation: UMMC JHS CC and FC
name: April P Carson, PhD
role: PRINCIPAL_INVESTIGATOR
affiliation: Mississippi State Department of Health JHS CEC
name: Victor Sutton, PhD
role: PRINCIPAL_INVESTIGATOR
affiliation: UMMC JHS GTEC
name: Jennifer Reneker, PhD
role: PRINCIPAL_INVESTIGATOR
References:
citation: Sempos CT, Bild DE, Manolio TA. Overview of the Jackson Heart Study: a study of cardiovascular diseases in African American men and women. Am J Med Sci. 1999 Mar;317(3):142-6. doi: 10.1097/00000441-199903000-00002.
citation: Crook ED, Taylor H. Traditional and non-traditional risk factors for cardiovascular and renal disease in African Americans: a project of the Jackson Heart Study investigators. Am J Med Sci. 2002 Sep;324(3):115. doi: 10.1097/00000441-200209000-00001. No abstract available.
citation: Wyatt SB, Williams DR, Calvin R, Henderson FC, Walker ER, Winters K. Racism and cardiovascular disease in African Americans. Am J Med Sci. 2003 Jun;325(6):315-31. doi: 10.1097/00000441-200306000-00003.
citation: Crook ED, Taylor H. Traditional and nontraditional risk factors for cardiovascular and renal disease in African Americans (Part 2): a project of the Jackson Heart Study investigators. Am J Med Sci. 2003 Jun;325(6):305-6. doi: 10.1097/00000441-200306000-00001. No abstract available.
citation: Wyatt SB, Diekelmann N, Henderson F, Andrew ME, Billingsley G, Felder SH, Fuqua S, Jackson PB. A community-driven model of research participation: the Jackson Heart Study Participant Recruitment and Retention Study. Ethn Dis. 2003 Fall;13(4):438-55.
citation: Taylor HA Jr. Establishing a foundation for cardiovascular disease research in an African-American community--the Jackson Heart Study. Ethn Dis. 2003 Fall;13(4):411-3.
citation: Taylor HA Jr, Clark BL, Garrison RJ, Andrew ME, Han H, Fox ER, Arnett DK, Samdarshi T, Jones DW. Relation of aortic valve sclerosis to risk of coronary heart disease in African-Americans. Am J Cardiol. 2005 Feb 1;95(3):401-4. doi: 10.1016/j.amjcard.2004.09.043.
citation: Carpenter MA, Crow R, Steffes M, Rock W, Heilbraun J, Evans G, Skelton T, Jensen R, Sarpong D. Laboratory, reading center, and coordinating center data management methods in the Jackson Heart Study. Am J Med Sci. 2004 Sep;328(3):131-44. doi: 10.1097/00000441-200409000-00001.
citation: Echouffo-Tcheugui JB, Mwasongwe SE, Musani SK, Hall ME, Correa A, Hernandez AF, Golden SH, Mentz RJ, Bertoni AG. Dysglycemia and incident heart failure among blacks: The jackson heart study. Am Heart J. 2022 Mar;245:1-9. doi: 10.1016/j.ahj.2021.11.003. Epub 2021 Nov 19.
citation: Rao VN, Bush CG, Mongraw-Chaffin M, Hall ME, Clark D 3rd, Fudim M, Correa A, Hammill BG, O'Brien E, Min YI, Mentz RJ. Regional Adiposity and Risk of Heart Failure and Mortality: The Jackson Heart Study. J Am Heart Assoc. 2021 Jul 20;10(14):e020920. doi: 10.1161/JAHA.121.020920. Epub 2021 Jul 9.
citation: Rosen DM, Kundel V, Rueschman M, Kaplan R, Guo N, Wilson JG, Min YI, Redline S, Shah N. Self-reported snoring and incident cardiovascular disease events: results from the Jackson Heart Study. Sleep Breath. 2019 Sep;23(3):777-784. doi: 10.1007/s11325-018-01776-1. Epub 2019 Feb 13.