louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT03647358: Lesion Dosimetry With Iodine-124 in Metastatic Thyroid Carcinoma
Official title: Lesion Dosimetry With Iodine-124 in Metastatic Thyroid Carcinoma
Study type: INTERVENTIONAL
Overall status: RECRUITING
Phase: PHASE1
Conditions: Thyroid Carcinoma
Metastatic Thyroid Carcinoma
Keywords: Iodine-124
PET Scan
18-253
Lead sponsor: Memorial Sloan Kettering Cancer Center
Sponsor class: OTHER
First posted: 2018-08-27
Enrollment: 60
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: DIAGNOSTIC

Brief summary: The purpose of this study is to evaluate a new diagnostic imaging test, positron emission tomography (PET), with a different radioactive form of iodine called iodine-124. This form is able to accurately measure the amount of radioactive iodine uptake in the cancer. If the new test determines sufficient radioiodine uptake in the cancer, treatment will continue as usual. However, if the new test shows only low radioiodine uptake, a decision may be made that the benefit from radioiodine therapy is insufficient and that another form of therapy is preferred.


Eligibility criteria: Inclusion Criteria:

* Adults with thyroid carcinoma confirmed by pathology.
* Adult thyroid carcinoma patients who have undergone total thyroidectomy
* Adult thyroid carcinoma patients have metastatic disease or suspicion for metastatic disease, or are under a protocol intended to explore re-induction therapy for 131I uptake, and are about to undergo Thyrogen-assisted dosimetry, unless Thyrogen-assisted dosimetry is not required per standard of care.
* The patient and physician are planning to administer 131I for therapy if persistent radioiodine-avid metastases are present.
* All subjects must have measurable disease, documented within the previous six months by ultrasonography (US), MRI, FDG PET/CT, or CT scanning.

Exclusion Criteria:

* Age less than 18 years.
* Patients who are pregnant.

Primary outcomes:
measure: number of individual lesions response
timeFrame: 1 year
Secondary outcomes:
Other outcomes:
Locations:
city: New York
country: United States
facility: Memorial Sloan Kettering Cancer Center
state: New York
city: New York
country: United States
facility: Weill Cornell Medical Center
state: New York
Study officials:
affiliation: Memorial Sloan Kettering Cancer Center
name: Ravinder Grewal, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT06103058: The Prevalence of Fibromyalgia in Adults at Al-Karak Jordan a Cross-sectional Study
Official title: The Prevalence of Fibromyalgia in Adults at Al-Karak Jordan a Cross-sectional Study
Study type: OBSERVATIONAL
Overall status: RECRUITING
Conditions: Fibromyalgia
Orthopedic Disorder
Lead sponsor: Mutah University
Sponsor class: OTHER
First posted: 2023-10-26
Enrollment: 965
Sex: ALL
Minimum age (years): 1
Maximum age (years): 100
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: OTHER
Time perspective: CROSS_SECTIONAL
Sampling method: PROBABILITY_SAMPLE
Study population: The study found a 26.5% prevalence of fibromyalgia in the studied population. Female gender, mental health illnesses, and comorbidities like irritable bowel syndrome, psychiatric disorders, and rheumatological and neurological diseases were significantly associated with fibromyalgia. Age, BMI, marital status, employment status, and certain comorbidities did not show statistically significant predictive value.

Discussion: The significant prevalence of fibromyalgia and its links to female gender, mental health problems, and comorbidities highlight the necessity for specific healthcare interventions and public awareness initiatives. The study's findings help to understand the imp

Brief summary: Fibromyalgia is a chronic and intricate musculoskeletal disorder characterized by widespread pain, fatigue, and tenderness in specific anatomical regions. Although its prevalence varies among populations, understanding the prevalence in different geographical areas is crucial for healthcare planning. This cross-sectional study aims to determine the prevalence of fibromyalgia in adults residing in Al-Karak, Jordan. The city's unique demographic and environmental characteristics may influence the occurrence of fibromyalgia among its adult population. The study aims to address gaps in knowledge, provide localized insights, and shed light on fibromyalgia's burden on the community's health. Accurate prevalence data aids healthcare planning and resource allocation.


Eligibility criteria: Using google forms, this cross-sectional study was carried out, and the participants were reached via social media platforms (5)

. Participants' autonomy was maintained, and no direct benefit was gained in return for filling out the questionnaire. The ethics committee at the Faculty of Medicine, Mutah University, Karak, Jordan, provided the required ethical approval prior to the initiation of this study. Moreover, the committee ensured that the study was designed according to the principles of the Declaration of Helsinki (Date: 13 February 2023. Reference number: 992023). In this study, the authors targeted Karak government citizens, in Jordan. Accordingly, the required sample size to achieve a 99% Confidence interval was 663 participants.

Primary outcomes:
measure: Cross sectional
timeFrame: 2 years
Secondary outcomes:
Other outcomes:
Locations:
city: Al-Karak
country: Jordan
facility: Mutah University
Study officials:
References:
Clinical trial NCT02778958: Comparisons of iv Ibuprofen and iv Paracetamol During Bariatric Surgery
Official title: Comparisons of iv Ibuprofen and iv Paracetamol for Postoperative Pain Levels and Opioid Consumption During Bariatric Surgery
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE4
Conditions: Bariatric Surgery Candidate
Obesity, Morbid
Keywords: bariatric surgery
morbid obesity
nonopioid analgesics
Lead sponsor: Inonu University
Sponsor class: OTHER
First posted: 2016-05-20
Enrollment: 40
Sex: ALL
Minimum age (years): 18
Maximum age (years): 65
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The aim of this study is to evaluate and to compare the effectiveness of iv ibuprofen and iv paracetamol during bariatric surgery.

Detailed description: Evaluation of effectiveness of iv ibuprofen and iv paracetamol on postoperative pain, opioid consumption, and side effects in morbidly obese patients undergoing bariatric laparoscopic surgery

Eligibility criteria: Inclusion Criteria:

* Patients undergoing laparoscopic sleeve gastrectomy and gastric by-pass surgery

Exclusion Criteria:

* Hepatic disfunction,
* Renal failure (creatinine \> 3 mg/dL,creatinin clearance \< 60 mL/dk or urine out-put \< 500 mL/day ) or a history of dialysis 28 days before surgery,
* A history of gastrointestinal bleeding or bleeding diathesis 6 weeks before surgery, therapeutic dose of anticoagulation therapy (except subcutaneous heparin prophylactic dose),
* Angiotensin converting enzymes inhibitor or antihypertensive combination with furosemide,
* A history of opioid addiction or opioid tolerance
* Allergy to study drugs,
* Noncooperative patients for pain assessments

Primary outcomes:
measure: Opioid (morphine) consumption
timeFrame: First 24 hours during postoperative period
Secondary outcomes:
measure: Postoperative pain level
timeFrame: First 24 hours during postoperative period
Other outcomes:
measure: Side effects
timeFrame: First 24 hours during postoperative period
Locations:
city: Malatya
country: Turkey
facility: Inonu University Faculty of Medicine Department of Anesthesiology and Reanimation
Study officials:
affiliation: Associated Professor Doctor Gulay ERDOGAN KAYHAN
name: Gulay Erdogan Kayhan, MD
role: PRINCIPAL_INVESTIGATOR
References:
citation: Kroll PB, Meadows L, Rock A, Pavliv L. A multicenter, randomized, double-blind, placebo-controlled trial of intravenous ibuprofen (i.v.-ibuprofen) in the management of postoperative pain following abdominal hysterectomy. Pain Pract. 2011 Jan-Feb;11(1):23-32. doi: 10.1111/j.1533-2500.2010.00402.x.
Clinical trial NCT07022158: Antenatal Body Shape Index and Pregnancy Complications
Official title: Relationship Between Antenatal Body Shape Index and Pregnancy Complications
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Gestational Complications
Body Mass Index
Waist Circumference
Gestational Hypertension
Gestational Diabetes Mellitus (GDM)
Preeclampsia (PE)
Keywords: gestational hypertension
gestational diabetes
preeclampsia
body shape index
waist circumference
Lead sponsor: Abant Izzet Baysal University
Sponsor class: OTHER
First posted: 2025-06-15
Enrollment: 170
Sex: FEMALE
Minimum age (years): 18
Maximum age (years): 43
Standard ages: ADULT
Accepts healthy volunteers: yes
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: 170 patients at 6-16th weeks of gestation

Brief summary: Background/aim: Gestational diabetes (GDM), gestational hypertension (GHT) and preeclampsia are common complications of pregnancy. In this study, it was aimed to determine the relationship between body shape index (ABSI), calculated based on antenatal measurements of the height, weight and waist circumference, and GDM, GHT and preeclampsia.

Materials and methods: 170 patients at 6-16th weeks of gestation were prospectively analyzed. Body mass index (BMI) and ABSI were calculated. Patients were analyzed according to the presence of GDM, GHT and preeclampsia at follow-up.

Our study is the first in terms of its subject and makes a significant contribution to the literature.


Eligibility criteria: Inclusion Criteria:

* Having a singleton pregnancy
* Pregnancy follow-up and birth must have taken place at Bolu Abant İzzet Baysal University Training and Research Hospital.
* Voluntary informed consent form must be signed to participate in the study.

Exclusion Criteria:

* Multiple pregnancies
* Additional systemic and chronic diseases (chronic hypertension, DM, hepatic diseases such as cholestasis, cardiac diseases, rheumatic diseases, renal diseases...)
* History of Gestational Diabetes, Gestational Hypertension and Preeclampsia in previous pregnancies

Primary outcomes:
measure: Calculation of body shape index at 6-16 weeks of gestation
timeFrame: 6-16 weeks of gestation
Secondary outcomes:
measure: Number of patients developing pregnancy complications
timeFrame: gestation period and first 6 weeks postpartum
Other outcomes:
Locations:
city: Bolu
country: Turkey
facility: Abant Izzet Baysal University Faculty of Medicine, 14030, Bolu, Turkey
Study officials:
References:
Clinical trial NCT04974658: Analgesic Efficacy of the Novel Intra- Semispinal Fascial Plane Block in Posterior Cervical Spine Surgery
Official title: Analgesic Efficacy of the Novel Intra- Semispinal Fascial Plane Block in Posterior Cervical Spine Surgery
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Cervical Spine Surgery
Lead sponsor: Zagazig University
Sponsor class: OTHER_GOV
First posted: 2021-07-23
Enrollment: 52
Sex: ALL
Minimum age (years): 18
Maximum age (years): 70
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Intervention model description: This study will be performed in neurosurgical operating rooms at Zagazig University Hospitals and included 52 patients allocated randomly into two groups: 26 patients recruited in the block group (I) for the Inter-semispinal plane block and 26 patients recruited in the (C) control group.
Primary purpose: OTHER

Brief summary: Posterior cervical spine surgery often requires a large posterior midline incision, resulting in poorly controlled postoperative pain, which arises from iatrogenic mechanical damage, intraoperative retraction, and resection to structures such as bone, ligaments, muscles, intervertebral discs, and zygapophysial joints.

Detailed description: Ultrasound-guided Inter-semispinal plane (ISP) block, was proposed as a novel technique for analgesia in posterior cervical spine surgeries. The ISP block involves an injection of local anesthetic into the fascial plane between the semispinalis cervicis and semispinal capitis muscles and results in blocking the dorsal rami of the cervical spinal nerves. ISP block can provide effective analgesia in posterior cervical spine surgery

Eligibility criteria: Inclusion Criteria:

* Patients' acceptance.
* ASA I , II andIII .
* Age between 18 years up to 70 years in both sexes.
* Patients with a BMI (body mass index) ranging from 18.5 to 30 kg/m2.
* Patients who scheduled for elective posterior cervical spine surgeries

Exclusion Criteria:

* Uncooperative patients
* Coagulopathy.
* Local tissue infection.
* Allergy to local anesthesia.

Primary outcomes:
measure: Total morphine consumed for 24 hours postoperative will be calculated.
timeFrame: Total morphine consumed up to 24 hours postoperative
Secondary outcomes:
measure: Total fentanyl consumed intraoperative will be calculated
timeFrame: total fentanyl dose that will be used for entire operative time.
measure: postoperative pain will be assessed using the Numerical Pain Score (NRS) score
timeFrame: NRS will be recorded 24 hours postoperative.
Other outcomes:
Locations:
city: Zagazig
country: Egypt
facility: Faculty of Medicine, Zagazig University
city: Zagazig
country: Egypt
facility: Faculty of medicine
Study officials:
affiliation: Faculty of medicine, Zagazig University Hospitals
name: Naglaa F Abdelhaleem, MD
role: PRINCIPAL_INVESTIGATOR
References:
citation: Ohgoshi Y, Kubo EN. Inter-semispinal plane block for cervical spine surgery. J Clin Anesth. 2018 May;46:94-95. doi: 10.1016/j.jclinane.2018.02.007. Epub 2018 Feb 9. No abstract available.
Clinical trial NCT03857958: Metal Versus Plastic Stent in Malignant Hilar Biliary Obstruction
Official title: Comparison of Metal Versus Plastic Side-by-side Stent Insertion in Malignant Hilar Biliary Obstruction
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Malignant Hepatobiliary Neoplasm
Lead sponsor: Seoul National University Hospital
Sponsor class: OTHER
Collaborators: name: Taewoong Medical Co., Ltd.
First posted: 2019-02-28
Enrollment: 54
Sex: ALL
Minimum age (years): 19
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The purpose of this study was to compare the difference in the stent patency duration between side-by-side fully covered self-expanding metal stents (SEMS) and side-by-side plastic stents in patients with malignant hilar biliary obstruction.

Detailed description: In the case of distal common bile duct obstruction, the SEMS was reported to be clinically superior to the plastic stent in previous studies. However, there are few studies comparing the two methods in patients with malignant hilar biliary obstruction. In contrast to the distal common bile duct obstruction, the advantage of plastic stents over SEMSs exists, and plastic stents are used commonly in real clinical practice.

Eligibility criteria: Inclusion Criteria:

* Unresectable malignant hilar biliary stricture requiring biliary drainage through endoscopic procedure

Exclusion Criteria:

* If endoscopy is not possible based on the judgement of the researcher
* Life expectancy less than 6 months
* Acute cholecystitis
* Previous history of percutaneous transhepatic biliary drainage
* Previous history of metal stent placement for malignant biliary stricture

Primary outcomes:
measure: Duration of stent patency
timeFrame: 9 months after randomization.
Secondary outcomes:
Other outcomes:
Locations:
city: Seoul
country: Korea, Republic of
facility: Seoul National University Hospital
Study officials:
affiliation: Seoul National University Hospital
name: Seoul National University Hospital Seoul National University Hospital, MD, PhD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT05655858: Observational Study of Allergic Rhinitis in Children
Official title: Observational Study of Allergic Rhinitis in Children
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Allergic Rhinitis
Lead sponsor: ALK-Abelló A/S
Sponsor class: INDUSTRY
First posted: 2022-12-19
Enrollment: 1000
Sex: ALL
Minimum age (years): 2
Maximum age (years): 18
Standard ages: CHILD
ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: 1000 patients aged 2 to 18 years old with allergic rhinitis

Brief summary: Observational, cross-sectional, prospective, multicentric study in France with private paediatricians to describe the management of allergic rhinitis in children.

Detailed description: Data collected about diagnostic, comorbidities, clinical history, management of allergic rhinitis using a patient paper case report form. There is only one visit per patient and investigators can include up to 10 patients.

Eligibility criteria: Inclusion Criteria:

* Under 18 years of age
* With allergic rhinitis
* Who's representative of the parental authority did not object to his child's participation after oral and written information and who agrees to participate

Exclusion Criteria:

* Child or adolescent opposed to participate or collect his personal data

Primary outcomes:
measure: Proportion of children over 2 years of age with allergic rhinitis eligible for allergic immunotherapy
timeFrame: 1 year
Secondary outcomes:
Other outcomes:
Locations:
city: Paris
country: France
facility: Hôpital Necker-Enfants malades - AP-HP Service de Pneumologie et Allergologie Pédiatriques
Study officials:
References:
Clinical trial NCT01458158: Matrix Metalloproteinases in Atherosclerosis of Chronic Kidney Disease
Official title: The Role of Matrix Metalloproteinases -2 and -9 in Atherosclerosis of Patients With Chronic Kidney Disease
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Diabetic Nephropathy
Keywords: Gelatinases
kidney disease
diabetes mellitus type 2
Lead sponsor: Aristotle University Of Thessaloniki
Sponsor class: OTHER
Collaborators: name: AHEPA University Hospital
First posted: 2011-10-24
Enrollment: 300
Sex: ALL
Minimum age (years): 50
Maximum age (years): 75
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: CASE_CONTROL
Time perspective: CROSS_SECTIONAL
Sampling method: PROBABILITY_SAMPLE
Study population: Patients from University Hospital AHEPA

Brief summary: The purpose of this study is to determine whether matrix metalloproteinases are associated with atherosclerosis in the different stages of chronic kidney disease.

Detailed description: The purpose of this study is to determine the correlation of matrix metalloproteinases and atherosclerosis of chronic kidney disease. Patients with diabetes mellitus type 2,as a non-inflammatory leading cause of end stage renal failure and patients with chronic glomerulonephritis and similar course of proteinuria,as an inflammatory leading cause of end stage renal failure are enrolled.

Eligibility criteria: Inclusion Criteria:

* Chronic kidney disease
* Diabetes mellitus type 2

Exclusion Criteria:

* Malignancy

Primary outcomes:
measure: Association of matrix metalloproteinases with atherosclerosis in patients with chronic kidney disease
timeFrame: two years
Secondary outcomes:
measure: Matrix metalloproteinases and atherosclerosis associated with pro-inflammatory and oxidative stress markers in chronic kidney disease
timeFrame: two years
Other outcomes:
Locations:
city: Thessaloniki
country: Greece
facility: AHEPA University Hospital, Medical School of Aristotle University of Thessaloniki
Study officials:
affiliation: AHEPA University Hospital,Medical School of Aristotle University of Thessaloniki
name: Grigorios G. Dimas, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT03141658: Effects of TS-134 on Ketamine-induced BOLD Signals in Healthy Subjects
Official title: A Randomized, Single-blind, Parallel-group Study to Evaluate the Effects of TS-134 on Ketamine-induced BOLD Signals in Resting fMRI in Healthy Adult Subjects
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE1
Conditions: Healthy Volunteers
Keywords: TS-134
ketamine
fMRI
Lead sponsor: Taisho Pharmaceutical R&D Inc.
Sponsor class: INDUSTRY
First posted: 2017-05-05
Enrollment: 63
Sex: ALL
Minimum age (years): 18
Maximum age (years): 55
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: BASIC_SCIENCE

Brief summary: The purpose of this study is to evaluate the effects of TS-134 on ketamine-induced BOLD signals in ROIs in resting fMRI in healthy adult subjects.


Eligibility criteria: Inclusion Criteria:

* Healthy adult male and female subjects between 18 and 55 years of age inclusive (at the time of initial informed consent)
* Body weight ≥ 45 and ≤ 87 kg
* Body Mass Index (BMI) ≥ 18 and ≤ 30 kg/m2

Exclusion Criteria:

* Female subjects who are pregnant, intend to become pregnant, or are breastfeeding
* History or presence of psychiatric or neurologic disease or condition
* History of first-degree relative with schizophrenia or mood disorder with psychosis
* History of alcohol or drug abuse
* History of recreational ketamine use, recreational PCP use, or an adverse reaction to ketamine
* History of violence
* Presence or positive history of significant medical illness, including high blood pressure, low blood pressure or orthostatic hypotension
* Any subjects who show subthreshold ketamine BOLD response
* Metal implants, pacemaker, other metal or paramagnetic objects contained within the body
* Claustrophobia
* Subject with any history of suicidal behavior or is currently at risk of suicide in the opinion of the investigator

Primary outcomes:
measure: BOLD fMRI signals in pre-specified ROIs
timeFrame: Screening and Day 6
Secondary outcomes:
measure: BOLD fMRI signals in whole brain
timeFrame: Screening and Day 6
measure: Brief Psychiatric Rating Scale (BPRS)
timeFrame: Screening and Day 6
measure: Clinician Administered Dissociative State Scale (CADSS)
timeFrame: Screening and Day 6
Other outcomes:
Locations:
city: New York
country: United States
facility: New York State Psychiatric Institute
state: New York
Study officials:
affiliation: New York State Psychiatric Institute
name: Jeffrey A Lieberman, MD
role: PRINCIPAL_INVESTIGATOR
References: