Clinical trial NCT05566639: A Study of mRNA-1010 Seasonal Influenza Vaccine in Adults 50 Years Old and Older
Official title: A Phase 3, Randomized, Observer-blind, Active-controlled Study to Evaluate the Safety and Efficacy of mRNA-1010 Candidate Seasonal Influenza Vaccine in Adults 50 Years and Older
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE3
Conditions: Seasonal Influenza
Keywords: Flu
Influenza
Vaccine
mRNA vaccine
mRNA-1010
Moderna
Lead sponsor: ModernaTX, Inc.
Sponsor class: INDUSTRY
First posted: 2022-10-04
Enrollment: 22502
Sex: ALL
Minimum age (years): 50
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: PREVENTION

Brief summary: The purpose of this study is to evaluate the safety and efficacy of mRNA-1010 in preventing seasonal influenza in adults 50 years and older.


Eligibility criteria: Inclusion Criteria:

* Investigator has assessed that the participant understands and is willing and physically able to comply with protocol mandated follow-up, including all procedures.

  * For female participants of childbearing potential: negative pregnancy test, adequate contraception or has abstained from all activities that could result in pregnancy for at least 28 days prior to the first dose on Day 1, and agreement to continue adequate contraception through 90 days following vaccine administration.

Exclusion Criteria:

* Participant has had close contact with someone with laboratory-confirmed influenza infection or with someone who has been treated with antiviral therapies for influenza (for example, Tamiflu®) within the past 5 days prior to the Screening visit.
* Participant has had close contact to someone with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection or COVID-19 as defined by the US CDC or has had a positive SARS-CoV-2 test in the past 10 days prior to the Screening visit.
* Participant is acutely ill or febrile (temperature ≥38.0℃elcius \[100.4°Fahrenheit\]) 72 hours prior to or at the Screening visit or Day 1. Participants meeting this criterion may be rescheduled within the 28-day screening window.
* Participant has a history of a diagnosis or condition that, in the judgment of the investigator, is clinically unstable or may affect participant safety, assessment of safety endpoints, assessment of immune response, or adherence to study procedures.
* Reported history of congenital or acquired immunodeficiency, immunocompromising/ immunosuppressive condition, asplenia, or recurrent severe infections.
* Reported history of anaphylaxis or severe hypersensitivity reaction after receipt of any mRNA or influenza vaccines or any components of the mRNA or influenza vaccines, including egg protein.
* Participant has received systemic immunosuppressant drugs for \>14 days in total within 180 days prior to the Screening visit (for glucocorticosteroids, ≥10 milligrams (mg)/day of prednisone or equivalent) or is anticipating the need for systemic immunosuppressive treatment at any time during participation in the study. Inhaled, nasal, and topical steroids are allowed.
* Participant has received any vaccine authorized or approved by local health agency ≤28 days prior to study intervention (Day 1) or plans to receive a vaccine authorized or approved by local health agency within 28 days before or after the study intervention.
* Participant is unaware whether they have received an influenza vaccine in the previous influenza season.
* Participant received a seasonal influenza vaccine or any other investigational influenza vaccine within 180 days prior to Day 1
* Participant has tested positive for influenza by local health authority-approved testing methods within 180 days prior to Day 1.
* Participant has donated ≥450 milliliters (mL) of blood products within 28 days prior to the Screening visit or plans to donate blood products during the study.

Note: Other inclusion and exclusion criteria may apply.

Primary outcomes:
measure: Number of Participants With Solicited Local and Systemic Reactogenicity Adverse Reactions (ARs)
timeFrame: 7 days post-vaccination
measure: Number of Participants With Unsolicited Adverse Events (AEs)
timeFrame: Up to 28 days post-vaccination
measure: Number of Participants With Serious Adverse Events (SAEs), AEs of Special Interest (AESIs), Medically Attended AEs (MAAEs), and AEs Leading to Discontinuation
timeFrame: Day 1 through Day 361 (Month 12)
measure: Number of Participants With First Episode of RT-PCR-Confirmed Protocol-Defined Influenza-Like Illness (ILI) Caused by Any Seasonal Influenza A or B Virus Strains Regardless of Antigenic Match to Strains Selected for the Seasonal Vaccine
timeFrame: 14 days post-vaccination through Day 181 (Month 6)
Secondary outcomes:
measure: Number of Participants With First Episode of RT-PCR-Confirmed Protocol-Defined ILI Caused by Influenza A or B Strains With Similarity to Those Selected for the Seasonal Vaccine
timeFrame: 14 days post-vaccination through Day 181 (Month 6)
measure: Number of Participants With First Episode of RT-PCR-Confirmed Protocol-Defined ILI Caused by Influenza A or B Strains Antigenically Matched to the Vaccine Strains Selected for the Seasonal Vaccine
timeFrame: 14 days post-vaccination through Day 181 (Month 6)
measure: Number of Participants With First Episode of RT-PCR Confirmed United States (US) Centers for Disease Control and Prevention (CDC)-Defined ILI Caused by Any Influenza A or B Strains
timeFrame: 14 days post-vaccination through Day 181 (Month 6)
measure: Number of Participants With First Episode of RT-PCR CDC-Defined ILI Caused by Influenza A or B Strains With Similarity to Vaccine Strains
timeFrame: 14 days post-vaccination through Day 181 (Month 6)
measure: Number of Participants With First Episode of RT-PCR CDC-Defined ILI Caused by Influenza A or B Strains That Were Antigenically Matched to Vaccine Strains
timeFrame: 14 days post-vaccination through Day 181 (Month 6)
measure: Number of Participants With First Episode of Culture-Confirmed Protocol-Defined ILI Caused by Any Seasonal Influenza A or B Virus Strains Regardless of Antigenic Match to Strains Selected for the Seasonal Vaccine
timeFrame: 14 days post-vaccination through Day 181 (Month 6)
measure: Number of Participants With First Episode of Culture-Confirmed CDC-Defined ILI Caused by Any Seasonal Influenza A or B Virus Strains Regardless of Antigenic Match to Strains Selected for the Seasonal Vaccine
timeFrame: 14 days post-vaccination through Day 181 (Month 6)
measure: Number of Participants With Hospitalizations Associated With RT-PCR Confirmed Protocol-Defined ILI Caused by Any Seasonal Influenza A or B Virus Strains Regardless of Antigenic Match to Strains Selected for the Seasonal Vaccine
timeFrame: 14 days post-vaccination through Day 181 (Month 6)
measure: Geometric Mean Titer (GMT) of Anti-Hemagglutinin (HA) Antibodies at Day 29, as Measured by Hemagglutination Inhibition (HAI) Assay for Vaccine-matched Influenza A and B Strains
timeFrame: Day 29
measure: Percentage of Participants Reaching Seroconversion at Day 29, as Measured by HAI Assay for Vaccine-matched Influenza A and B Strains
timeFrame: Day 29
measure: Percentage of Participants With HAI Titer ≥ 1:40 at Day 29
timeFrame: Day 29
measure: Geometric Mean Fold Rise (GMFR) of Anti-HA Antibodies at Day 29, as Measured by HAI Assay for Vaccine-matched Influenza A and B Strains
timeFrame: Baseline, Day 29
Other outcomes:
Locations:
city: Athens
country: United States
facility: North Alabama Research Center, LLC
state: Alabama
city: Glendale
country: United States
facility: Lenzmeier Family Medicine
state: Arizona
city: Phoenix
country: United States
facility: CCT Research
state: Arizona
city: Tempe
country: United States
facility: Fiel Family and Sports Medicine/CCT Research
state: Arizona
city: Tucson
country: United States
facility: Noble Clinical Research
state: Arizona
city: Little Rock
country: United States
facility: Lynn Institute of the Ozarks
state: Arkansas
city: Little Rock
country: United States
facility: Baptist Health Center for Clinical Research
state: Arkansas
city: Banning
country: United States
facility: Velocity Clinical Research, Banning
state: California
city: Canoga Park
country: United States
facility: Hope Clinical Research, LLC
state: California
city: Huntington Beach
country: United States
facility: Marvel Clinical Research
state: California
city: La Mesa
country: United States
facility: Velocity Clinical Research, Chula Vista
state: California
city: La Mesa
country: United States
facility: Velocity Clinical Research, San Diego
state: California
city: Los Angeles
country: United States
facility: Velocity Clinical Research - Westlake
state: California
city: Pomona
country: United States
facility: Empire Clinical Research
state: California
city: Riverside
country: United States
facility: Artemis Institute for Clinical Research
state: California
city: Riverside
country: United States
facility: Benchmark Research-Texas
state: California
city: Rolling Hills Estates
country: United States
facility: Peninsula Research Associates (PRA)
state: California
city: San Diego
country: United States
facility: Artemis Institute for Clinical Research
state: California
city: San Diego
country: United States
facility: Women's Health Care Research Corp.
state: California
city: San Diego
country: United States
facility: Acclaim Clinical Research
state: California
city: San Diego
country: United States
facility: Medical Center for Clinical Research
state: California
city: San Francisco
country: United States
facility: Shawn K Hassler MD
state: California
city: San Ramon
country: United States
facility: West Coast Research LLC
state: California
city: Denver
country: United States
facility: Velocity Clinical Research, Denver
state: Colorado
city: Fort Collins
country: United States
facility: Arthritis & Rheumatology - Clinic of Northern Colorado
state: Colorado
city: Longmont
country: United States
facility: Longmont Medical Research Network
state: Colorado
city: Crystal River
country: United States
facility: Nature Coast Clinical Research, LLC - Crystal River
state: Florida
city: Hialeah
country: United States
facility: Floridian Clinical Research
state: Florida
city: Hialeah
country: United States
facility: Homestead Associates in Research,Inc
state: Florida
city: Hollywood
country: United States
facility: Broward Research Group
state: Florida
city: Inverness
country: United States
facility: Citrus Cardiology Consultants
state: Florida
city: Jacksonville
country: United States
facility: Encore Research Group-Jacksonville Center for Clinical Resea
state: Florida
city: Jupiter
country: United States
facility: Health Awareness, Inc
state: Florida
city: Lake City
country: United States
facility: Multi-Therapeutic Research Associates, Inc.
state: Florida
city: Lakeland
country: United States
facility: Accel Research Sites - Lakeland
state: Florida
city: Maitland
country: United States
facility: ARS - Meridien Research
state: Florida
city: Miami Lakes
country: United States
facility: Global Health Research Center
state: Florida
city: Miami
country: United States
facility: South Florida Research Center, Inc.
state: Florida
city: Miami
country: United States
facility: Suncoast Research Associates Trials, LLC
state: Florida
city: Miami
country: United States
facility: Miami centre of clinical research
state: Florida
city: Miami
country: United States
facility: Clinical Trials of Florida, LLC
state: Florida
city: Palmetto Bay
country: United States
facility: Innovation Medical Research Center,inc
state: Florida
city: Tampa
country: United States
facility: New Tampa Health, Inc
state: Florida
city: Chamblee
country: United States
facility: Tekton Research, Inc.
state: Georgia
city: Columbus
country: United States
facility: Southeast Regional Research Group
state: Georgia
city: Decatur
country: United States
facility: iResearch Atlanta, LLC
state: Georgia
city: Norcross
country: United States
facility: In-Quest Medical Research
state: Georgia
city: Sandy Springs
country: United States
facility: Mount Vernon Clinical Research
state: Georgia
city: Savannah
country: United States
facility: Meridian Clinical Research - Savannah
state: Georgia
city: Stockbridge
country: United States
facility: Clinical Research Atlanta
state: Georgia
city: Meridian
country: United States
facility: Velocity Clinical Research - Boise
state: Idaho
city: Chicago
country: United States
facility: Great Lakes Clinical Trials LLC
state: Illinois
city: Chicago
country: United States
facility: Great Lakes Clinical Trials LLC
state: Illinois
city: Gurnee
country: United States
facility: Great Lakes Clinical Trials LLC
state: Illinois
city: River Forest
country: United States
facility: Chicago Health Medical Group
state: Illinois
city: Valparaiso
country: United States
facility: Velocity Clinical Research - Valparaiso
state: Indiana
city: Sioux City
country: United States
facility: Meridian Clinical Research - Dakota Dunes
state: Iowa
city: Lenexa
country: United States
facility: Johnson County Clin-Trials (JCCT)
state: Kansas
city: Newton
country: United States
facility: Heartland Research Associates LLC
state: Kansas
city: Wichita
country: United States
facility: Alliance for Multispecialty Research
state: Kansas
city: Baton Rouge
country: United States
facility: Meridian Clinical Research
state: Louisiana
city: Covington
country: United States
facility: MedPharmics
state: Louisiana
city: Metairie
country: United States
facility: Medpharmics, LLC
state: Louisiana
city: New Orleans
country: United States
facility: Nathan H Fischman MD LLC
state: Louisiana
city: Annapolis
country: United States
facility: Privia Medical Group
state: Maryland
city: Rockville
country: United States
facility: Rockville Internal Medicine Group
state: Maryland
city: Springfield
country: United States
facility: Delricht Research
state: Massachusetts
city: Southfield
country: United States
facility: DM Clinical Research - Detroit
state: Michigan
city: Biloxi
country: United States
facility: Paul G Matherne MD
state: Mississippi
city: Gulfport
country: United States
facility: DELRICHT RESEARCH at GULFPORT MEMORIAL
state: Mississippi
city: Saint Louis
country: United States
facility: Sundance Clinical Research, LLC
state: Missouri
city: Springfield
country: United States
facility: National Medical University and Embryonic Tissues Center EmC
state: Missouri
city: Missoula
country: United States
facility: Montana Medical Research, Inc
state: Montana
city: Elkhorn
country: United States
facility: CCT Research at Skyline Medical Center, PC
state: Nebraska
city: Fremont
country: United States
facility: CCT Research / Methodist Physicians Clinic, Prairie Fields Family Medicine, PC
state: Nebraska
city: Grand Island
country: United States
facility: Meridian Clinical Research
state: Nebraska
city: Lincoln
country: United States
facility: Be Well Clinical Studies, LLC
state: Nebraska
city: Norfolk
country: United States
facility: Medpace, Inc. - Clinical Pharmacology Unit (CPU)
state: Nebraska
city: Norfolk
country: United States
facility: Meridian Clinical Research
state: Nebraska
city: Omaha
country: United States
facility: Papillon Research Centre
state: Nebraska
city: Omaha
country: United States
facility: Meridian Clinical Research - Omaha
state: Nebraska
city: Omaha
country: United States
facility: Midwest Regional Health Services, LLC/CCT Research
state: Nebraska
city: Las Vegas
country: United States
facility: CCT Research
state: Nevada
city: Las Vegas
country: United States
facility: Clinical Research Center of Nevada LLC
state: Nevada
city: Las Vegas
country: United States
facility: Santa Rosa Medical Centers of Nevada/ CCT Research
state: Nevada
city: North Las Vegas
country: United States
facility: Las Vegas Clinical Trials, LLC
state: Nevada
city: Binghamton
country: United States
facility: United Medical Associates
state: New York
city: Rochester
country: United States
facility: Rochester Clinical Research, Inc
state: New York
city: Syracuse
country: United States
facility: Velocity Clinical Research - Syracuse
state: New York
city: Charlotte
country: United States
facility: Tryon Medical Group
state: North Carolina
city: Fayetteville
country: United States
facility: Carolina Institute for Clinical Research
state: North Carolina
city: Morehead City
country: United States
facility: Diabetes & Endocrinology Consultants
state: North Carolina
city: Raleigh
country: United States
facility: M3 Wake Research, Inc.
state: North Carolina
city: Wilmington
country: United States
facility: PMG Research of Wilmington
state: North Carolina
city: Wilmington
country: United States
facility: Trial Management Associates
state: North Carolina
city: Winston-Salem
country: United States
facility: Wake Forest Baptist Medical Center
state: North Carolina
city: Akron
country: United States
facility: Radiant Research
state: Ohio
city: Cincinnati
country: United States
facility: Sterling Research Group
state: Ohio
city: Cincinnati
country: United States
facility: CTI Clinical Research Center
state: Ohio
city: Cincinnati
country: United States
facility: Velocity Clinical Research - Cincinnati
state: Ohio
city: Oklahoma City
country: United States
facility: Lynn Health Science Institute
state: Oklahoma
city: Tulsa
country: United States
facility: Delricht Research Tulsa
state: Oklahoma
city: Yukon
country: United States
facility: Platinum Research Network, LLC
state: Oklahoma
city: Grants Pass
country: United States
facility: Velocity Clinical Research - Grants Pass
state: Oregon
city: Medford
country: United States
facility: Velocity Clinical Resarch - Medford
state: Oregon
city: Warwick
country: United States
facility: Velocity Clinical Research - Providence
state: Rhode Island
city: Anderson
country: United States
facility: Velocity Clinical Research, Greenville
state: South Carolina
city: Columbia
country: United States
facility: Velocity Clinical Research - Columbia
state: South Carolina
city: Gaffney
country: United States
facility: Velocity Clinical Research, Gaffney
state: South Carolina
city: Greenville
country: United States
facility: Velocity Clinical Research - Greenville
state: South Carolina
city: Myrtle Beach
country: United States
facility: Carolina Health Specialists
state: South Carolina
city: Spartanburg
country: United States
facility: Spartanburg Regional Health Services
state: South Carolina
city: Rapid City
country: United States
facility: Black Hills Center for American Indian Health
state: South Dakota
city: Hendersonville
country: United States
facility: Delricht Research
state: Tennessee
city: Austin
country: United States
facility: Tekton Research, Inc
state: Texas
city: Beaumont
country: United States
facility: Platinum Research Network, LLC
state: Texas
city: Dallas
country: United States
facility: Zenos Clinical Research
state: Texas
city: Fort Worth
country: United States
facility: Benchmark Research
state: Texas
city: Houston
country: United States
facility: DM Clinical Research
state: Texas
city: Houston
country: United States
facility: Texas Center for Drug Development, Inc.
state: Texas
city: McKinney
country: United States
facility: DELRICHT RESEARCH at ZOMNIR FAMILY MEDICINE
state: Texas
city: Plano
country: United States
facility: Research Your Health
state: Texas
city: Red Oak
country: United States
facility: Epic Medical Research, LLC
state: Texas
city: San Antonio
country: United States
facility: Clinical Trials of Texas, Inc
state: Texas
city: Sugar Land
country: United States
facility: DM Clinical Research
state: Texas
city: Sugar Land
country: United States
facility: Breco Research - A Tarheel Clinical Research Site
state: Texas
city: Bountiful
country: United States
facility: Cope Family Medicine
state: Utah
city: Holladay
country: United States
facility: Olympus Family Medicine/CCT Research
state: Utah
city: Salt Lake City
country: United States
facility: CenExel - JBR
state: Utah
city: South Ogden
country: United States
facility: South Ogden Family Medicine clinic/CCT
state: Utah
city: West Jordan
country: United States
facility: Velocity Clinical Research - Salt Lake City
state: Utah
city: Portsmouth
country: United States
facility: Meridian Clinical Research
state: Virginia
city: Richmond
country: United States
facility: Clinical Research Partners, LLC
state: Virginia
city: Suffolk
country: United States
facility: Lakeview Medical Center
state: Virginia
city: Kozloduy
country: Bulgaria
facility: MHAT Sveti Ivan Rilski
city: Montana
country: Bulgaria
facility: MC City Clinic Sveti Georgi - Montana
city: Montana
country: Bulgaria
facility: MHAT "Dr. Stamen Iliev
city: Pleven
country: Bulgaria
facility: Medical Center Medconsult Pleven
city: Sofia
country: Bulgaria
facility: Military Medical Academy
city: Sofia
country: Bulgaria
facility: SHAT of Pneumo-phthisiatric diseases - Sofia District
city: Brampton
country: Canada
facility: Aggarwal and Associates LTD
city: Burlington
country: Canada
facility: Aviva Clinical Trials Group Inc
city: Hamilton
country: Canada
facility: Hamilton Medical Research Group
city: Kelowna
country: Canada
facility: Okanagan Clinical Trials
city: Levis
country: Canada
facility: Centricity Research Quebec City
city: London
country: Canada
facility: Milestone Research Inc.
city: Ottawa
country: Canada
facility: Yang Medicine
city: Pointe-Claire
country: Canada
facility: LMC Manna
city: Quebec
country: Canada
facility: DIEX Research Quebec Inc.
city: Quebec
country: Canada
facility: DIEX Research Quebec Inc.
city: Quebec
country: Canada
facility: Alpha Recherche Clinique Inc
city: Quebec
country: Canada
facility: Clinique de Lebourgneuf
city: Quebec
country: Canada
facility: Clinique spécialisée en allergie - Allergy/Immunology/Asthma/Mpoc
city: Quebec
country: Canada
facility: Diex Research Sherbrooke Inc
city: Red Deer
country: Canada
facility: Central Alberta Research Clinic
city: Saint-Charles-Borromée
country: Canada
facility: Diex Recherche - Joilette - HyperCore - PPDS
city: Sarnia
country: Canada
facility: Glencar Medical Inc.
city: Toronto
country: Canada
facility: Canadian Phase Onward Inc.
city: Toronto
country: Canada
facility: LMC
city: Toronto
country: Canada
facility: Manna Research
city: Toronto
country: Canada
facility: Medicine Professional Corporation
city: Toronto
country: Canada
facility: Toronto Western Hospital
city: Trois-Rivieres
country: Canada
facility: Diex Recherche Trois-Rivières
city: Truro
country: Canada
facility: Colchester East Hants Health Authority - Colchester Regional
city: Victoriaville
country: Canada
facility: Diex Recherche Victoriaville
city: Odense
country: Denmark
facility: Odense University Hospital
city: Roskilde
country: Denmark
facility: Sjællands UniHosp, Roskilde - Medicine and Infectious Diseases
city: Århus N
country: Denmark
facility: Aarhus Universitetshospital
city: Tallinn
country: Estonia
facility: Center for Clinical and Basic Research
city: Tallinn
country: Estonia
facility: Innomedica OÜ
city: Tallinn
country: Estonia
facility: Merelahe Family Doctors Centre
city: Tartu
country: Estonia
facility: Clinical Research Center
city: Berlin
country: Germany
facility: Berliner Centrum für Reise- und Tropenmedizin
city: Berlin
country: Germany
facility: Emovis GmbH
city: Berlin
country: Germany
facility: Klinische Forschung Berlin-Mitte GmbH
city: Berlin
country: Germany
facility: Klinische Forschung Berlin
city: Dresden
country: Germany
facility: Klinische Forschung Dresden GmbH
city: Essen
country: Germany
facility: Medizentrum Essen Borbeck
city: Frankfurt/Main
country: Germany
facility: Studienzentrum Dr. Keller
city: Frankfurt
country: Germany
facility: IKF Pneumologie
city: Frankfurt
country: Germany
facility: Infektiologikum Frankfurt-Sachsenhausen
city: Hamburg
country: Germany
facility: Clinical Research Hamburg GmbH
city: Hamburg
country: Germany
facility: Klinische Forschung Hamburg GmbH
city: Hannover
country: Germany
facility: Klinische Forschung Hannover-Mitte GmbH
city: Hannover
country: Germany
facility: Siteworks GmbH
city: Heidelberg
country: Germany
facility: Siteworks GmbH
city: Köln
country: Germany
facility: University Hospital Cologne AöR
city: Leipzig
country: Germany
facility: Synexus Clinical Research GmbH
city: Magdeburg
country: Germany
facility: Praxis Illies
city: Mainz
country: Germany
facility: Dermatologie Quist
city: Oldenburg
country: Germany
facility: Praxis Schaum
city: Schwerin
country: Germany
facility: Klinische Forschung Schwerin GmbH
city: Stuttgart
country: Germany
facility: Hautarztpraxis Leitz & Kollegen
city: Wardenburg
country: Germany
facility: Studienzentrum Brinkum
city: Leiden
country: Netherlands
facility: Leids Universitair Medisch Centrum (LUMC)
city: Utrecht
country: Netherlands
facility: Universitair Medisch Centrum (UMC) Utrecht - Julius Center for Health Sciences and Primary Care
city: Bydgoszcz
country: Poland
facility: Centrum Medyczne Pratia Bydgoszcz
city: Krakow
country: Poland
facility: Centrum Medyczne Plejady
city: Kraków
country: Poland
facility: Krakowskie Centrum Medyczne Sp. z o.o.
city: Lodz
country: Poland
facility: Centrum Medyczne AMED Oddzial w Lodzi
city: Lublin
country: Poland
facility: ETG Lublin
city: Lublin
country: Poland
facility: KO-MED Centra Kliniczne Lublin II
city: Skierniewice
country: Poland
facility: ETG Skierniewice
city: Warszawa
country: Poland
facility: Centrum Innowacyjnych Terapii Sp. z o.o.
city: Warszawa
country: Poland
facility: Provita Centrum Medyczne Sp. z o.o.
city: Warszawa
country: Poland
facility: RCMed
city: Zamosc
country: Poland
facility: ETG Zamosc
city: Zamosc
country: Poland
facility: KO-MED Centra Kliniczne Sp. z o.o.
city: Antequera
country: Spain
facility: Hospital de Antequera
city: Barcelona
country: Spain
facility: Hospital Clinic De Barcelona
city: Barcelona
country: Spain
facility: Hospital Santa Creu i Sant Pau - Research institut
city: Barcelona
country: Spain
facility: Universitat Autonoma de Barcelona (UAB) - Institut d'Investigacio en Atencio Primaria Jordi Gol (IDIAP Jordi Gol)
city: Vigo
country: Spain
facility: Hospital Alvaro Cunqueiro
city: Vigo
country: Spain
facility: Hospital Povisa
city: Kaohsiung City
country: Taiwan
facility: Kaohsiung Veterans General Hospital
city: Taichung
country: Taiwan
facility: China Medical University Hospital - division of Rheumatology - Taichung
city: Tainan
country: Taiwan
facility: National Cheng Kung University hospital
city: Taipei
country: Taiwan
facility: National Taiwan University Hospital - Family Medicine
city: Taipei
country: Taiwan
facility: Taipei Medical University - Taipei Medical University Hospital
city: Taipei
country: Taiwan
facility: Taipei Medical University - WanFang Hospital
city: Taipei
country: Taiwan
facility: Tri-Service General Hospital - Neihu Branch - Infectious Diseases
city: Bath
country: United Kingdom
facility: Royal United Hospital
city: Blackpool
country: United Kingdom
facility: Layton Medical Centre
city: Hull
country: United Kingdom
facility: Hull University Teaching Hospitals NHS Foundation trust
city: Leicester
country: United Kingdom
facility: University Hospitals of Leicester-Leicester Royal Hospital
city: Liverpool
country: United Kingdom
facility: Liverpool University Hospitals NHS Foundation Trust - Aintree University Hospital (Fazakerley Hospital)
city: London
country: United Kingdom
facility: GST NHS Found
city: Newcastle
country: United Kingdom
facility: Newcastle University - Institute of Cellular Medicine (ICM)
city: Rochdale
country: United Kingdom
facility: Panthera Biopartners - Manchester - multispeciality
city: Rochdale
country: United Kingdom
facility: Panthera Biopartners - Sheffield - multispeciality
city: Salford
country: United Kingdom
facility: Panthera Biopartners - Preston - multispeciality
city: Southampton
country: United Kingdom
facility: Southampton General Hospital
city: Truro
country: United Kingdom
facility: Royal Cornwall Hospitals Trust - Respiratory
Study officials:
References: