Clinical trial NCT05220696: Central Venous Oxygen Saturation and Carbone Dioxide (CO2)-Derived Indices in the Critically:
Official title: Central Venous Oxygen Saturation and Carbone Dioxide (CO2)-Derived Indices in the Critically: Correlation of Measurements According to the Site of Harvest (Femoral Versus Jugular Vein)
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Shock
Keywords: Adult > 18 YO
Venous catheter in femoral and jugular sites
Arterial catheter
central venous to arterial carbon dioxide difference
central venous to arterial carbon dioxide difference to arterial to venous oxygen difference
central venous oxygen saturation
Lead sponsor: University Hospital, Montpellier
Sponsor class: OTHER
First posted: 2022-02-02
Enrollment: 42
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Critically ill patients

Brief summary: The optimal management of shock states requires a precise evaluation of several parameters, clinical, biological, hemodynamic, and echocardiographic. Among these, parameters that measure O2 and CO2 consumption are of a great interest, especially PCO2 arteriovenous gradient (PCO2 gap) and O2 arteriovenous difference \[D(a-v) O2\]. The PCO2 gap best correlates with cardiac output while the PCO2gap/D(a-v)O2 ratio would be earlier and more specific than blood lactate assay in assessing tissue hypoperfusion secondary to shock.

The PCO2 gap and the PCO2gap/D (a-v) O2 ratio have been evaluated from gas measurements of venous blood collected from the pulmonary artery and from the superior vena cava area. However, in some patients the placement of a catheter in the superior vena cava is difficult or even impossible due to thrombosis, vascular occlusions and other reasons... In these cases, the inferior vena cava is used for drugs infusion, nutrition and possibly samples. Gasometric samples in lower cellar territory have not yet been validated and may not be correlated with measurements in upper cellar territory. It is therefore useful for current practice to validate samples in lower cellar territory and demonstrate their correlation with measurements made in upper cellar territory.

During an observation period, in patients with catheters in the superior and inferior vena cava for therapeutic indications (renal replacement therapy,...), the investigators systematically took gas measurements at the femoral and jugular sites. the investigators used these data to assess the correlation of PCO2 gap measurements and carbon dioxide-derived indices according to the harvest site : jugular and femoral venous.


Eligibility criteria: Inclusion criteria:

- All consecutive critically ill patients who had an arterial catheter and a venous catheter in the superior and inferior vena cava were included.

Exclusion criteria:

* An age under 18
* Pregnancy
* Legally protected adults

Primary outcomes:
measure: The correlation of the measurement of indices derived from carbon dioxide (CO2)
timeFrame: day 1
Secondary outcomes:
measure: To assess the correlation of the measurement of venous O2 saturation
timeFrame: day 1
Other outcomes:
Locations:
city: Montpellier
country: France
facility: Uhmontpellier
Study officials:
affiliation: UH Montpellier
name: Kada KLOUCHE, MD PhD
role: STUDY_DIRECTOR
References: