louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT06734325: Mobile Oral Health Intervention Effectiveness on Orthodontic Patients' Oral Hygiene and Oral Health Literacy
Official title: Effectiveness of Mobile Oral Health Intervention on Oral Hygiene and Oral Health Literacy Among Orthodontic Patients: a Randomized Controlled Clinical Trial)
Study type: INTERVENTIONAL
Overall status: RECRUITING
Phase: NA
Conditions: Oral Health Literacy
Oral Hygiene
Keywords: oral health literacy
oral hygiene
orthodontic patients
mobile oral health intervention
whatsapp
messages
Lead sponsor: Alexandria University
Sponsor class: OTHER
First posted: 2024-12-16
Enrollment: 60
Sex: ALL
Minimum age (years): 16
Maximum age (years): 25
Standard ages: CHILD
ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: PREVENTION

Brief summary: Orthodontic patients face unique challenges in maintaining optimal oral hygiene due to the presence of fixed orthodontic appliances, which tend to increase plaque retention, leading to gingival inflammation. Oral Health Literacy (OHL) plays a role in an individual's ability to understand and implement oral hygiene instructions effectively. Mobile oral health interventions involve the use of mobile technology such as smartphones to improve oral hygiene practices and outcomes.

Aim of the study: To assess the effectiveness of a mobile oral health intervention using WhatsApp messages as compared to standard oral hygiene instructions on oral hygiene status and OHL level among orthodontic patients.


Eligibility criteria: Inclusion Criteria:

1. Patients undergoing orthodontic treatment with fixed appliances in both arches for the first time.
2. Patients between the age of 16 and 25 years.
3. Participants must own a smartphone with WhatsApp installed.
4. Those who agree to be part of the research project and accept the informed consent.

Exclusion Criteria:

1. The presence of systemic diseases affecting oral health.
2. Patients with cleft lip and/or palate.
3. Functional and orthognathic patients.
4. Previous orthodontic treatment.
5. Patients with a removable appliance.

Primary outcomes:
measure: Oral Health Literacy
timeFrame: Change from baseline to 1 month, 3 months, 6 months
Secondary outcomes:
measure: Oral Hygiene
timeFrame: Change from baseline to 1 month, 3 months, 6 months
Other outcomes:
Locations:
city: Alexandria
country: Egypt
facility: Faculty of Dentistry, Alexandria University
Study officials:
affiliation: Teaching Assistant, Faculty of Dentistry, Alexandria University, Egypt
name: Nermine Balbaa, BDS
role: PRINCIPAL_INVESTIGATOR
References:
citation: Pubalan S, Zi Hong O, Yongxian T, Mabel L. Assessing effectiveness of WhatsApp messaging program in oral hygiene care for orthodontic patients: A randomised controlled trial. J Orthod. 2024 Dec;51(4):407-414. doi: 10.1177/14653125241230561. Epub 2024 Feb 17.
citation: Cho HA, Im AJ, Sim YR, Jang HB, Lim HJ. The association between oral health literacy and oral health behaviors in North Korean defectors: a cross-sectional study. BMC Public Health. 2020 Jul 7;20(1):1074. doi: 10.1186/s12889-020-08550-7.
Clinical trial NCT00005348: Adipose Distribution and Atherosclerosis
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Cardiovascular Diseases
Heart Diseases
Carotid Stenosis
Lead sponsor: National Heart, Lung, and Blood Institute (NHLBI)
Sponsor class: NIH
First posted: 2000-05-26
Sex: MALE
Maximum age (years): 100
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no

Brief summary: To relate distribution of adipose tissue measured by a then new imaging technique, Magnetic Resonance Imaging (MRI) to extracranial carotid atherosclerosis, cardiovascular disease risk factors, and to more conventional measures of fat distribution such as body mass index (BMI) and waist/hip ratio. The primary hypothesis was that patients with extracranial carotid atherosclerosis (cases) had more intra-abdominal fat and a higher ratio of intra-abdominal fat to total or subcutaneous fat than age-sex-race matched controls.

Detailed description: BACKGROUND:

The study was ancillary to an NIH funded population-based project, the Atherosclerosis Risk in Communities Study (ARIC) that is ongoing in Forsyth County, North Carolina.

DESIGN NARRATIVE:

Using MRI, the investigators sought to demonstrate strong relationships between intra-abdominal fat and a number of cardiovascular disease risk factors, including history of hypertension, diabetes, cigarette smoking, family history of cardiovascular disease, plasma concentrations of triglyceride, high density lipoprotein (HDL) cholesterol, HDL2 cholesterol, apo A1, Apo B, postprandial lipid response to a fat rich meal, glucose, insulin, sex hormone binding globulin, and total and free testosterone. Certain other risk factors were less certain to show a relation to intra-abdominal fat as measured by MRI, including various hemostatic factors, as well as certain dietary factors such as consumption of alcohol, dietary fat, and cholesterol, but this research afforded an opportunity to explore these relationships. Finally, the investigators proposed to relate intra-abdominal fat to more conventional measures of fat distribution (waist/hip ratio, subscapular skinfold thickness, etc.) in an attempt to identify strong correlates of intra-abdominal fat that could be more easily measured.

The study completion date listed in this record was obtained from the "End Date" entered in the Protocol Registration and Results System (PRS) recor

Eligibility criteria: No eligibility criteria

Primary outcomes:
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
References:
citation: Terry JG, Hinson WH, Evans GW, Schreiner PJ, Hagaman AP, Crouse JR 3rd. Evaluation of magnetic resonance imaging for quantification of intraabdominal fat in human beings by spin-echo and inversion-recovery protocols. Am J Clin Nutr. 1995 Aug;62(2):297-301. doi: 10.1093/ajcn/62.2.297.
Clinical trial NCT00213330: Cerebral Resonance Magnetic Imaging During Rectal Distention
Official title: Cerebral Activity During Rectal Pain in Patients With Irritable Bowel Syndrome or Inflammatory Bowel Disease:Resonance Magnetic Imaging Study.
Study type: OBSERVATIONAL
Overall status: WITHDRAWN
Conditions: Ulcerative Colitis
Irritable Bowel Syndrome
Keywords: cerebral activity
rectal distension
colitis ulcerative
irritable bowel syndrome
magnetic resonance imaging
Lead sponsor: University Hospital, Rouen
Sponsor class: OTHER
First posted: 2005-09-21
Enrollment: 0
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: CASE_CONTROL
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: healthy subjects and patients with irritable bowel syndrome

Brief summary: Irritable bowel syndrome is responsible for chronic abdominal pain, diarrhea and/or constipation. It is a very frequent problem. However, the exact cause of irritable bowel syndrome remains unknown. The purpose of this study is to look for a different cerebral response by magnetic resonance imaging after rectal stimulation in patients with irritable bowel syndrome compared to healthy subjects and to patients with digestive organic disease. Our hypothesis is that irritable bowel syndrome could be a problem of cerebral integration of visceral stimulation.


Eligibility criteria: Inclusion Criteria:

* healthy subjects irritable bowel syndrome (Rome II criteria) colitis ulcerative

Exclusion Criteria:

pregnant or breast feeding metallic material implanted good tolerance of rectal distension acute phase of ulcerative colitis

Primary outcomes:
Secondary outcomes:
Other outcomes:
Locations:
city: Rouen
country: France
facility: University hospital of Rouen
Study officials:
affiliation: University Hospital, Rouen
name: Emmanuel Gérardin, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT03927430: Surgical Outcome of Macular Membrane Peeling Associated With Significant Macular Drusen
Official title: To Peel or Not to Peel: Surgical Outcome of Macular Membrane Peeling Associated With Significant Macular Drusen
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Epiretinal Membrane
Macular Holes
Age Related Macular Degeneration
Lead sponsor: Klinikum Chemnitz gGmbH
Sponsor class: OTHER
First posted: 2019-04-25
Enrollment: 40
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: CASE_ONLY
Time perspective: RETROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: mostly elderly people, mean age 66 years, both males and females

Brief summary: Surgical outcome of patients with macular drusen and co-existing abnormalities of the vitreoretinal interface, who routinely undergo pars plana vitrectomy with membrane peeling, is evaluated. Best corrected visual acuity as well as optical coherence tomography data are compared at baseline and last follow up. The rate of development of choroidal neovascularization postoperatively is noted.


Eligibility criteria: Inclusion Criteria:

1. participants diagnosed with ERM or FTMH and co-existing macular drusen;
2. undergone pars plana vitrectomy with ILM and epiretinale membrane peeling;
3. SD-OCT at the initial visit and at last follow up visit with image quality score \>30;
4. no evidence of CNV on initial fluorescein angiography (FA).

Exclusion Criteria:

1. history of other macular disease, severe non-proliferative or proliferative diabetic retinopathy, other retinal vascular diseases, glaucoma, myopic retinopathy, or other diseases interfering with OCT images in any one of the eyes;
2. active CNV or history of CNV

Primary outcomes:
measure: number of patients with CNV
timeFrame: last visit, in common 6 months postoperatively
Secondary outcomes:
measure: BCVA
timeFrame: last visit, in common 6 months postoperatively
measure: incidence of central retinal atrophy
timeFrame: last visit, in common 6 months postoperatively
Other outcomes:
Locations:
city: Chemnitz
country: Germany
facility: Klinikum Chemnitz, Ophthalmology Department
state: Saxony
Study officials:
affiliation: Klinikum Chemnitz
name: Katrin Engelmann, PhD
role: STUDY_CHAIR
References:
Clinical trial NCT01513330: Performance Study of Newly Developed Ostomy Products
Official title: An Open-labelled, Randomised, Controlled, Crossover Investigation Evaluating Performance of a Newly Developed Ostomy Care Product Compared to Standard Care.
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE4
Conditions: Stoma Colostomy
Lead sponsor: Coloplast A/S
Sponsor class: INDUSTRY
First posted: 2012-01-20
Enrollment: 122
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: CROSSOVER
Primary purpose: PREVENTION

Brief summary: The purpose of the study is to evaluate leakage of a newly developed ostomy product compared to standard care in subjects with colostomies. Subjects will be asked to use each test product for 2 weeks - in total, the study period is 4 weeks and the hypothesis is to show that the newly developed ostomy product is significantly better to reduce leakage compared to standard care.


Eligibility criteria: Inclusion Criteria:

1. Have given written informed consent.
2. Be at least 18 years of age and have full legal capacity.
3. Have experienced leakage under the base plate at least once a week over the last two weeks.
4. Be able to handle the bags themselves or with help from caregiver (e.g. spouse).
5. Have a colostomy with a diameter between 20 and 45 mm.
6. Have had their ostomy for at least three months.
7. Currently use a 1-piece flat product with closed bag.
8. Use minimum 1 product per day.
9. Be suitable for participation in the investigation and for using a standard adhesive, flat base plate (evaluated by investigator).

Exclusion Criteria:

1. Use irrigation during the study (flush the stoma with water).
2. Currently receiving or have within the past 2 months received radio- and/or chemotherapy.
3. Currently receiving or have within the past month received local or systemic steroid treatment in the peristomal area.
4. Are pregnant or breastfeeding.
5. Participating in other interventional clinical investigations or have previously participated in this investigation.

Primary outcomes:
measure: Degree of Leakage. Each Baseplate Can Have a Score From 0-24 Points Were 0 is the Best Possible Outcome (No Leakage) and 24 Points is the Worst Possible Outcome (Full Plate Leakage)
timeFrame: 14 days
Secondary outcomes:
Other outcomes:
Locations:
city: Cologne
country: Germany
facility: Publicare
state: Køln
Study officials:
affiliation: Diakonhjemmet Sykhus, Oslo
name: Wenche Sundberg, stoma nurse
role: PRINCIPAL_INVESTIGATOR
affiliation: St. Olavs Hopsital
name: Merete Bjørke, Stoma Nurse
role: PRINCIPAL_INVESTIGATOR
affiliation: Haugesund Sykhus
name: Vigids Dagsland, Stoma Nurse
role: PRINCIPAL_INVESTIGATOR
affiliation: St. Olavs Hospital
name: Randi Melum, Stoma Nurse
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT00124930: Study Comparing Olanzapine With Haloperidol for the Relief of Nausea and Vomiting in Patients With Advanced Cancer
Official title: A Randomized Double-blind, Parallel Group Study Comparing Olanzapine (Zyprexa) With Haloperidol (Novo-peridol) for the Relief of Nausea and Vomiting in Patients With Advanced Cancer
Study type: INTERVENTIONAL
Overall status: TERMINATED
Phase: PHASE3
Conditions: Nausea
Neoplasms
Keywords: olanzapine
haldol
cancer
nausea
second line treatment
refractory nausea
Lead sponsor: AHS Cancer Control Alberta
Sponsor class: OTHER
Collaborators: name: Canadian Institutes of Health Research (CIHR)
First posted: 2005-07-29
Enrollment: 80
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The purpose of this study is to compare the efficacy and safety of Haldol (haloperidol) and olanzapine in the control of chronic nausea with advanced cancer patients who have failed first line antiemetic therapy.

Detailed description: The purpose of this study is to compare the efficacy and safety of haloperidol and olanzapine in the control of chronic nausea with advanced cancer patients who have failed first line antiemetic therapy.

Eligibility criteria: Inclusion Criteria:

* \>18 years of age
* Significant nausea/vomiting
* Failed maxeran and domperidone
* Underlying treatment of causes has failed
* Adequate cognitive function
* Communicates well

Exclusion Criteria:

* Partial/complete bowel obstruction
* Currently taking Haldol or olanzapine
* Has drug induced extrapyramidal symptoms
* Parkinson's disease
* Undergoing chemotherapy or radiotherapy (RT) to brain, abdomen, stomach or esophagus

Primary outcomes:
measure: Severity of nausea on days 3 and 5
Secondary outcomes:
Other outcomes:
Locations:
city: Calgary
country: Canada
facility: Tom Baker Cancer Centre
state: Alberta
Study officials:
affiliation: Alberta Cancerboard
name: Jose Pereira
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT03837548: A Study of Neurofeedback for the Treatment of Parkinson's Disease
Official title: A Phase 1 Double-Blind Crossover Comparative Study of Neurofeedback for the Treatment of Parkinson's Disease
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Parkinson Disease
Keywords: Parkinson's Disease
Magnetoencephalography
Neurofeedback
Lead sponsor: Osaka University
Sponsor class: OTHER
Collaborators: name: Japan Agency for Medical Research and Development
First posted: 2019-02-12
Enrollment: 20
Sex: ALL
Minimum age (years): 20
Maximum age (years): 90
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: CROSSOVER
Primary purpose: TREATMENT

Brief summary: This study aims to reveal relationship between brain activities and the symptoms of Parkinson disease when a neurofeedback training was applied for them.


Eligibility criteria: Inclusion Criteria:

* Subjects with age more than 20
* Subjects obtained the consent
* Subjects with Parkinson disease and healthy subjects

Exclusion Criteria:

* The subjects who can not conduct the tasks
* Subjects with severe illness
* Subjects whom the experimenter think as in appropriate
* Subjects with implantable devices such as pacemaker

Primary outcomes:
measure: Alteration of Brain Activities
timeFrame: At the time Immediately following the training
Secondary outcomes:
measure: The raw score change from baseline in the Movement disorder society-Unified Parkinson's Disease Rating Scale (MDS-UPDRS) part Ⅲ scores
timeFrame: At the time Immediately following the training
Other outcomes:
Locations:
city: Suita-City
country: Japan
facility: Osaka University
state: Osaka-fu
Study officials:
References:
Clinical trial NCT02245048: CIMT and Plaque Assessment Findings in Subjects Undergoing Stress Echocardiography For Risk Stratification
Official title: Carotid Intima-Media Thickness and Plaque Assessment Findings in Subjects Undergoing Stress Echocardiography For Risk Stratification
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Cardiovascular Risk Stratification
Carotid Intima-media Thickness (CIMT)
Stress Echocardiography (SE)
Keywords: Cardiovascular Risk Stratification
Carotid intima-media thickness (CIMT)
Stress echocardiography (SE)
Lead sponsor: Mayo Clinic
Sponsor class: OTHER
Collaborators: name: Esaote North America
First posted: 2014-09-19
Enrollment: 73
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Eligible patients will be undergoing standard of care stress echocardiography

Brief summary: The purpose of this research study is to determine if carotid artery ultrasound scanning can provide additional information for determining cardiovascular risk in patients.

Patients who agree to participate wil undergo non-invasive carotid intima-media thickness (CIMT) measurement and plaque assessment. Findings of CIMT will be compared to results of patient standard of care stress echocardiogram (SE) and of diastolic function.

We hypothesize tht 1) in patients undergoing SE for inappropriate or uncertain indications, CIMT and plaque assessment will provide useful risk stratification beyond use of traditional risk factors; 2) CIMT findings will correlate with results of SE in terms of exercise capacity and 3) Exercise capacity will correlate with diastolic function.


Eligibility criteria: Inclusion Criteria:

* Asymptomatic
* No prior cardiac history (MI, PTCA, CABG, angina)
* No peripheral vascular disease
* No history of stroke or TIA
* Statins, antihypertensives, ASA treatment OK

Exclusion Criteria:

* History of CAD, CABG, PTCA, coronary or peripheral stenting
* History of stroke/TIA/peripheral vascular disease
* Inability to exercise on the treadmill
* Unwilling/unable to sign informed consent
* History of neck radiation or neck surgery or inability to obtain neck images
* End stage renal disease
* Preoperative evaluation
* History of chest pain

Primary outcomes:
measure: % Patients w/ Abnormal IMT vs. % Patients w/ Positive Ischemia on Stress Echocardiogram
timeFrame: Baseline
Secondary outcomes:
Other outcomes:
Locations:
city: Scottsdale
country: United States
facility: Mayo Clinic
state: Arizona
Study officials:
affiliation: Mayo Clinic
name: Tasneem Naqvi, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT04183348: Evaluation of the Effect of a Visio-Hearing Training Protocol on Spatial Hearing in Subjects With Hearing Loss
Official title: Evaluation of the Effect of a Visio-Hearing Training Protocol on Spatial Hearing in Subjects With Hearing Loss
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Cochlear Nerve Deafness
Cochlear Diseases
Cochlear Hearing Loss
Hearing Loss
Deafness
Lead sponsor: Hospices Civils de Lyon
Sponsor class: OTHER
First posted: 2019-12-03
Enrollment: 79
Sex: ALL
Minimum age (years): 18
Maximum age (years): 65
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: CROSSOVER
Primary purpose: OTHER

Brief summary: We recently developed a new Neuro-immersion system based on virtual reality and 3D (dimension) motion tracking. This tool makes it possible to evaluate and record the spatial localization performance of sounds and to highlight localization deficits in the three dimensions of space in deaf patients. Unfortunately, there is currently no suitable support to compensate for these localization deficits. However, the discomfort felt by the patients is clearly verbalized.

Thanks to the new virtual reality system, we are now able to develop a training protocol based on spatial sound localization tasks.


Eligibility criteria: Inclusion Criteria:

For all participants (patients and normal hearing adults):

* Ages 18 and 65
* Normal vision (with or without correction)
* Able to understand experimental instructions
* Member of the social security scheme
* Informed of the study and signed the consent form

For hearing standards (NH):

- No hearing problems

For patients (SU, uIC and bIC):

* Regular follow-up in the ENT (Ear, nose, and throat) department of the Edouard Herriot Hospital in Lyon or the Purpan Hospital, in Toulouse
* Unilateral deep deafness (only for SU patients)
* Holder of one Cochlear implant for more than one year (only for uIC patients)
* Holder of the second Cochlear implant for more than one year (only for bIC patients)

Exclusion Criteria:

* Oculomotor disorder
* Bilateral vestibular areflexia
* Neurological and/or psychiatric history
* Person placed under legal protection, guardianship or trusteeship
* Pregnant or nursing woman

Primary outcomes:
measure: Composite measure of spatial localization auditory tasks effect of each training protocol on spatial auditory performances
timeFrame: 1 day
Secondary outcomes:
measure: Measure of the sensory feedback effect on spatial auditory performance by comparing the composite measure of the two training protocols
timeFrame: 1 day
Other outcomes:
Locations:
city: Bron
country: France
facility: Service d'Oto-Rhino-Laryngologie et Chirurgie cervico-faciale, Hôpital Edouard Herriot
city: Toulouse
country: France
facility: Service d'Oto-Rhino-Laryngologie et Chirurgie cervico-faciale, Hôpital Purpan, CHU de Toulouse
Study officials:
References: