Clinical trial NCT06479915: Estimate the Relationship Between Oral Microbiota and Stroke
Official title: Access the Influence of Oral Microbiota in the Onset and Evolution of Stroke, With Focus on Cerebral Microbleeds
Study type: OBSERVATIONAL
Overall status: RECRUITING
Conditions: Stroke
Microbial Disease
Keywords: cnm
Streptococcus mutans
Cerebal microbleeds
Cerebral hemorrhage
Cerebral ischemia
cnm-positive streptococcus mutans
Lead sponsor: Fujian Medical University
Sponsor class: OTHER
Collaborators: name: First Affiliated Hospital of Fujian Medical University
First posted: 2024-06-28
Enrollment: 200
Sex: ALL
Minimum age (years): 18
Maximum age (years): 90
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: OTHER
Time perspective: RETROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: small cerebral vessel disease

Brief summary: Oral bacteria constitute the second largest population of the human microbiome. Recent studies have identified their role in the development of systemic diseases, such as cardiovascular and cerebrovascular diseases. Streptococcus Mutans (SM) is considered the primary pathogen responsible for dental caries. Furthermore, in cases of oral inflammatory diseases, SM has been found to invade the bloodstream and disseminate, leading to systemic diseases. Against this backdrop, this study aims to investigate disparities in oral flora between stroke patients and healthy individuals by collecting saliva samples from both groups.

Detailed description: Oral bacteria constitute the second largest population of the human microbiome. Recent studies have identified their role in the development of systemic diseases, such as cardiovascular and cerebrovascular diseases. Streptococcus Mutans (SM) is considered the primary pathogen responsible for dental caries. Furthermore, in cases of oral inflammatory diseases, SM has been found to invade the bloodstream and disseminate, leading to systemic diseases. Against this backdrop, this study aims to investigate disparities in oral flora between stroke patients and healthy individuals by collecting saliva samples from both groups. The objective of this study is to offer novel insights into the association between oral health and cerebrovascular disease occurrence while establishing a foundation for future research.

Eligibility criteria: Inclusion Criteria:

* 1. Microbleeding/damage or rupture of small blood vessels in the brain has been diagnosed within the past 365 days 2. Have done nuclear magnetic examination and can provide nuclear magnetic results

Exclusion Criteria:

* Have received antibiotic quality within the last three months

Primary outcomes:
measure: Estimate the Relationship Between Oral Microbiota and Stroke
timeFrame: 2025.06
measure: Correlation Between Oral Microbiota and Cerebral Microbleeds in Stroke
timeFrame: 2025.06
Secondary outcomes:
Other outcomes:
Locations:
city: Fuzhou
country: China
facility: School and Hospital of stomatology,Fujian Medical University,Fuzhou,Fujian Province,350002,China
state: Fujian
city: Fuzhou
country: China
facility: The First Affiliated Hospital of Fujian Medical University
state: Fujian
Study officials:
affiliation: School and Hospital of Stomatology,Fujian Medical University,fuzhou,Fujian Province,350002,China
name: XiaoJing Huang
role: STUDY_CHAIR
References: