Clinical trial NCT03224975: Acute Pain Memory Among Former Burned: Exploration of fMRI.
Official title: Acute Pain Memory Among Former Burned: Exploration of Functional Magnetic Resonance Imaging (fMRI).
Study type: INTERVENTIONAL
Overall status: TERMINATED
Phase: NA
Conditions: Magnetic Resonance Imaging
Neuronal Activity
Keywords: Pain
Brain responses
Neuroimaging
fMRI
Burn
Memory
Lead sponsor: Centre Hospitalier Universitaire de Saint Etienne
Sponsor class: OTHER
First posted: 2017-07-21
Enrollment: 24
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: NON_RANDOMIZED
Intervention model: PARALLEL
Intervention model description: Two groups: 20 patients and 20 healthy volunteers
Primary purpose: OTHER

Brief summary: Pain is complex phenomenon misunderstood in spite of medical progress and neurosciences. That's why the relief of chronic pain is only partial for a lot of infection as arthrosis, chronic back pain, headaches or neuropathic pain. Certain situations bring to relive pain sensation. Investigators were interested to former burned. They wonder about somatic memory and unconscious of acute.

Detailed description: It is a comparative and monocentric study. There are two groups. On the one hand, there is the former burned and, on the other hand, healthy volunteers. While they thought to painful memory or not, functional Magnetic Resonance Imaging (fMRI) will be performed. Then, investigators compare two functional Magnetic Resonance Imaging (fMRI).

Main objective of this study is link up between brain activity by functional Magnetic Resonance Imaging (fMRI) and acute pain memory.

Eligibility criteria: Inclusion Criteria:

For control group:

* Affiliated or entitled to a social security
* Have signed consent before their participation in the study
* Adult women and men french and is right handed
* Vision and hearing normal or corrected

For former burned:

* Affiliated or entitled to a social security
* Have signed consent before their participation in the study
* Adult women and men french and is right handed
* Vision and hearing normal or corrected
* Localized burn at the hand or feet onset between 12 and 24 years
* Not sequelae painful at the inclusion
* Scope and depth of the burn according to classifications CIM 10

Exclusion Criteria:

For control group:

* Any contraindications to pass an fMRI test
* Neuropathic pains and psychiatric disorders
* Medical history of head injuries
* Burn presence

For former burned:

* Any contraindications to pass an fMRI test
* Neuropathic pains and psychiatric disorders
* Medical history of head injuries

Primary outcomes:
measure: BOLD (blood-oxygen-level dependent) signal between painful memories
timeFrame: Months 3
measure: BOLD (blood-oxygen-level dependent) signal between emotional memories not painful
timeFrame: Months 3
measure: BOLD (blood-oxygen-level dependent) signal between neutral memories
timeFrame: Months 3
measure: BOLD (blood-oxygen-level dependent) signal between control test.
timeFrame: Months 3
Secondary outcomes:
measure: BOLD (blood-oxygen-level dependent) signal between control group for every conditions
timeFrame: Months 3
measure: BOLD (blood-oxygen-level dependent) signal between patients for every conditions
timeFrame: Months 3
Other outcomes:
Locations:
city: Saint-Etienne
country: France
facility: CHU de Saint-Etienne
Study officials:
affiliation: CHU SAINT-ETIENNE
name: Jean-Claude GETENET, MD
role: PRINCIPAL_INVESTIGATOR
References: