louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT02544906: Propofol Versus Dexmedetomidine for Prevention of Sevoflurane Agitation in Recipients of Living Donor Liver Transplantation
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Liver Transplantation
Keywords: recipients
Lead sponsor: Mansoura University
Sponsor class: OTHER
First posted: 2015-09-09
Enrollment: 120
Sex: ALL
Minimum age (years): 30
Maximum age (years): 60
Standard ages: ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: PREVENTION

Brief summary: The use of propofol or dexmedetomedine for prevention of sevofurane emergence agitation in LDLT recipients


Eligibility criteria: Inclusion Criteria:

* All recipients of living donor liver transplantation

Exclusion Criteria:

* patient refusal Allergy to either propofol or dexmedetomediene CNS disease

Primary outcomes:
measure: incidence of emergence agitation in liver trasnplant recipients
timeFrame: 24 hours
Secondary outcomes:
Other outcomes:
Locations:
city: Mansoura
country: Egypt
facility: Mansoura university
state: Dkahleya
Study officials:
References:
Clinical trial NCT05069506: Effects of Goat Milk Yogurt on Postprandial Glycemic Responses, Arterial Blood Pressure and Energy Intake
Official title: Short-term Effects of Goat Milk Yogurt on Postprandial Glycemic Responses, Arterial Blood Pressure, Energy Intake and Satiety
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Potential Abnormality of Glucose Tolerance
Appetite; Lack or Loss, Nonorganic Origin
Lead sponsor: Agricultural University of Athens
Sponsor class: OTHER
First posted: 2021-10-06
Enrollment: 62
Sex: ALL
Minimum age (years): 18
Maximum age (years): 50
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: CROSSOVER
Intervention model description: Other: Glucose as reference food Other: goat milk yogurt as test food Other: goat milk yogurt with currants as test food Other: currants as test food Other: sultanina raisins as test food Other: goat milk preload Other: milk with lactic acid preload
Primary purpose: OTHER

Brief summary: This study investigated any potential associations between two preloads offered as snacks and postprandial glycemic response, subjective appetite and energy intake in healthy, normal weight adults

Detailed description: This study aimed at 1. firstly determine the glycemic index (GI) of a) goat milk yogurt b) goat milk yogurt with currants, c) currants and d) sultanina raisins, all containing 25 gr available carbohydrates and 2. test the hypothesis that a goat milk yogurt consumed as a snack before a meal, compared to milk with lactic acid would: a) have greater short-term effect on satiety measured by subsequent ad libitum meal intake, b) induce greater satiety as assessed by visual analogue scales (VAS) and c) reduce postprandial glycemic response.

Eligibility criteria: Inclusion Criteria:

* Healthy, non-smoking, non-diabetic men and women individuals with normal body mass index (BMI; between 18.5 and 24.9 kg/m2)

Exclusion Criteria:

* Severe chronic disease (e.g. tumors, manifest coronary heart disease, diabetes mellitus, severe kidney or liver conditions, endocrine and immunological conditions)
* Gastrointestinal disorders (e.g. chronic inflammatory bowel disease)
* Lactose intolerance
* Pregnancy
* Competitive sports
* Lactation
* Alcohol
* Drug dependency

Primary outcomes:
measure: Capillary blood glucose
timeFrame: 7 hours
Secondary outcomes:
measure: Subjective appetite ratings
timeFrame: 7 hours
measure: Energy intake after preload
timeFrame: 6 hours
measure: Arterial blood pressure
timeFrame: 7 hours
Other outcomes:
Locations:
city: Athens
country: Greece
facility: Agricultural University of Athens
Study officials:
References:
Clinical trial NCT06693206: Investigation of Burnout, Musculoskeletal System and Aerobic Capacity in Nurses
Official title: Investigation of Burnout, Musculoskeletal System, Physical Performance and Perception of Exercise Benefit / Obstacle and Aerobic Capacity in Nurses
Study type: OBSERVATIONAL
Overall status: NOT_YET_RECRUITING
Conditions: Aerobic Capacity
Keywords: nurse
aerobic capacity
burnout
Lead sponsor: Firat University
Sponsor class: OTHER
First posted: 2024-11-18
Enrollment: 30
Sex: FEMALE
Minimum age (years): 18
Maximum age (years): 65
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: OTHER
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: The study will include 30 female nurses who work in Fırat University Hospital on normal shift and do not have any chronic disease.

Brief summary: The aim of our study was to evaluate the relationship of aerobic capacity with burnout status, musculoskeletal system, physical performance and exercise benefit/obstacle perception in nurses, who have an important place in the health profession group, and to bring the results to the literature. Demographic information will be obtained from the participants who volunteered to participate in the study. Burnout, musculoskeletal pain and physical performance will be evaluated with relevant scales and aerobic capacity will be measured with a bicycle ergometer.

Detailed description: In the literature, there are studies on the general effects of aerobic exercises on the cardiovascular system, musculoskeletal system, endocrine system, nervous system and psychosocial status. However, despite the benefits of aerobic exercises and the physiological and psychological importance of high aerobic capacity, there are no studies in the literature that examine the factors associated with the aerobic capacity of nurses. These factors affect the professional life of nursesThe aim of our study was to evaluate the relationship of aerobic capacity with burnout status, musculoskeletal system, physical performance and exercise benefit/obstacle perception in nurses, who have an important place in the health profession group, and to bring the results to the literature. Demographic information will be obtained from the participants who volunteered to participate in the study. Burnout, musculoskeletal pain and physical performance will be evaluated with relevant scales and aerobic capacity will be measured with a bicycle ergometer.

Eligibility criteria: Inclusion Criteria:

* 18-65 years old
* At least 1 year of experience
* Nurses not working in the academic field

Exclusion Criteria:

* Pregnancy
* Malignancy
* Nurses with lower extremity problems

Primary outcomes:
measure: Aerobic capacity assessment
timeFrame: up to 30 minutes
Secondary outcomes:
measure: Burnout assessment
timeFrame: up to 30 minutes
measure: Musculoskeletal evaluation
timeFrame: up to 30 minutes
Other outcomes:
Locations:
Study officials:
affiliation: Firat University
name: Songul Baglan Yentur
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT01679106: The Effects of Continuous Transversus Abdominis Plane (TAP) Catheters on Postoperative Pain After Renal Transplantation
Study type: INTERVENTIONAL
Overall status: TERMINATED
Phase: NA
Conditions: Pain
Keywords: renal transplant
flank incision
Lead sponsor: The Cleveland Clinic
Sponsor class: OTHER
First posted: 2012-09-05
Enrollment: 3
Sex: ALL
Minimum age (years): 18
Maximum age (years): 80
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: SUPPORTIVE_CARE

Brief summary: Up to 174 patients undergoing renal transplantation will be randomized to one of two groups. Randomization will be based on computer-generated codes using random block sizes ranging from 4 to 8.

Group 1: TAP catheter with continuous infusion of Ropivicaine Group 2: Fentanyl IV PCA

The TAP catheter will be removed 48 hours postoperatively. Following removal, the pain scores will be assessed at 60 and 72 hours postoperatively to determine any prolonged analgesic benefit. In addition, the presence of any pain at the incision site will be noted at the 1 month surgical follow-up to determine any evidence of chronic pain.

The investigators hypothesis is that unilateral kidney transplant patients with a continuous TAP catheter will have decreased pain scores and opioid usage compared to those receiving standard analgesic therapy.


Eligibility criteria: Inclusion Criteria:

* The patient is \>18 years of age
* The patient has provided written informed consent and understands the explanation of the protocol.
* The patient is scheduled to have a unilateral renal transplant with a flank incision

Exclusion Criteria:

* Patients aged \<18.
* Patients with a known allergy to amide local anesthetics or para-aminobenzoic acid.
* Patients who are unable to understand the verbal analog pain scale.
* Patients who decline participation.
* Patients with a midline abdominal incision.
* Combined transplants, ie. Kidney-pancreas

Primary outcomes:
measure: Effect of continuous TAP analgesia and pain scores
timeFrame: day 1
measure: Effect of TAP analgesia and opioid requirements
timeFrame: Day 1
measure: Effect of continuous TAP analgesia on pain scores
timeFrame: Day 2
measure: effect of continuous TAP analgesia on pain scores
timeFrame: Day 3
measure: Effect of continuous TAP analgesia on pain scores
timeFrame: 30 days
measure: Effect of TAP analgesia on opioid requirements
timeFrame: Day 2
measure: Effect of TAP analgesia on opioid requirements
timeFrame: Day 3
measure: Effect of TAP analgesia on opioid requirements
timeFrame: Day 30
Secondary outcomes:
Other outcomes:
Locations:
city: Cleveland
country: United States
facility: Cleveland Clinic
state: Ohio
Study officials:
affiliation: The Cleveland Clinic
name: Ehab Farag, M.D.
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT02498249: Immediate Effect of Irradiation With Low-level Laser Therapy on the Electromyographic Activity of the Upper Trapezius Muscles and the Level of Pain Among Patients With Non-specific Neck Pain
Official title: Immediate Effect of Irradiation With Low-level Laser Therapy on the Electromyographic Activity of the Upper Trapezius Muscles and the Level of Pain Among Patients With Non-specific Neck Pain: a Randomized, Double-blinded, Sham-controlled, Crossover Study
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE1
PHASE2
Conditions: Neck Pain Treatment
Keywords: Low-Level Laser Therapy
trapezius muscle
neck pain
Lead sponsor: University of Nove de Julho
Sponsor class: OTHER
Collaborators: name: Simone Aparecida Penimpedo Calamita
name: Fabiana Sarilho de Mendonça
name: Daniela Aparecida Biasotto-Gonzalez
name: Marco Antônio Fumagalli
name: Paulo de Tarso Camilo de Camargo
First posted: 2015-07-15
Enrollment: 20
Sex: ALL
Minimum age (years): 18
Maximum age (years): 40
Standard ages: ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: CROSSOVER
Primary purpose: TREATMENT

Brief summary: The aim of the present study is to assess the immediate effect of irradiation with low level laser therapy (LLLT) on the electromyographic activity of upper trapezius muscles and the amount of pain felt by patients with non-specific neck pain (NS-NP).A total of 20 patients with non-specific neck pain will be enrolled in a randomized, single-blind, crossover study. Each subject will receive two forms of treatment in random order: a single session of LLLT and placebo LLLT. In order to eliminate carry-over treatment effects, a one-week wash-out period will be respected between sessions. Surface electromyography will be used to determine nerve conduction velocity and activity in the upper trapezius muscles before and after treatment. The outcome measures will be determined by a numerical pain rating scale. Comparisons before and after irradiation with LLLT will determine the activity of the upper trapezius muscles and the level of pain. The data will be submitted to statistical tests considering a p-value of p \< 0.05.


Eligibility criteria: Inclusion Criteria:

* 18 to 40 years
* Male and female volunteers
* History of neck pain for a period of more than two months
* Score ranging from 15 to 24 on the Neck Disability Index
* Score ranging from three to seven points on an 11-point (range: 0 to 10) numerical rating scale (NRS) for perceived pain intensity

Exclusion Criteria:

* history of neurological disorders
* neck surgery
* chronic neck pain resulting from a traumatic incident
* chronic musculoskeletal condition
* medical diagnosis of fibromyalgia; systemic disease
* connective tissue disorder
* having undergone physical therapy use of analgesic, muscle relaxant.

Primary outcomes:
measure: Electromyographic activity
timeFrame: 1 Year
Secondary outcomes:
measure: Numerical rating scale score for pain
timeFrame: 1 Year
Other outcomes:
Locations:
city: São Paulo
country: Brazil
facility: Nove de Julho University
Study officials:
References:
Clinical trial NCT06988449: Use of ST250 to Reconstruct Lateral Tongue Defects
Official title: Use of ST250 to Reconstruct Lateral Tongue Defects
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Tongue Neoplasms
Keywords: tongue defect
reconstruction
Polylactide membrane
Lead sponsor: Cairo University
Sponsor class: OTHER
Collaborators: name: Marienhospital Stuttgart
First posted: 2025-05-23
Enrollment: 10
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: In hospital patients

Brief summary: To assess the use of SupraThel 250 for mucosal reconstruction in the Head \& Neck region. The membrane is applied to reconstruct lateral tongue defects . healing of the mucosa and regaining of normal tongue movement and speech are assessed postoperatively.

Detailed description: Lateral tongue defects are usually treated using radial fore-arm free grafts which require a prolonged hospital stay with higher morbidity rates. It also entails the need of multiple rehabilitation and remodeling porcdures of the transplnted flap to enable intelligible speech and tongue function.

Eligibility criteria: Inclusion Criteria:

* lateral tunge defects (postoncologic resection)

Exclusion Criteria:

* radio / chemotherapy
* pregnant/ breastfeeding women

Primary outcomes:
measure: Pain score
timeFrame: 5 days
Secondary outcomes:
Other outcomes:
Locations:
city: Stuttgart
country: Germany
facility: MarienHospital
state: Baden-Wurttemberg
Study officials:
affiliation: Marienhospital Stuttgart
name: Dorothee Rickert, PhD
role: PRINCIPAL_INVESTIGATOR
References:
citation: Sarin V, Chatterjee A, Kakkar V, Juneja A. Evaluation of Tongue Functions After Free Flap Reconstruction. Indian J Otolaryngol Head Neck Surg. 2022 Oct;74(Suppl 2):2398-2403. doi: 10.1007/s12070-020-02177-1. Epub 2020 Oct 8.
Clinical trial NCT04154449: Effect of Intranasal Insulin on Postoperative Cognitive Dysfunction
Official title: Effect of Intranasal Insulin on Postoperative Cognitive Dysfunction in Middle Aged Patients Undergoing Non Cadiac Surgery.
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Middle Aged Patients
Lead sponsor: Minia University
Sponsor class: OTHER
First posted: 2019-11-06
Enrollment: 57
Sex: ALL
Minimum age (years): 40
Maximum age (years): 60
Standard ages: ADULT
Accepts healthy volunteers: yes
Observational model: CASE_CONTROL
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: 1. Age 40 - 60 years.
2. Both gender.
3. Patients will be scheduled for elective major abdominal, thoracic, orthopedic, open gynecological, open urological, spine, otolaryngological surgeries under general anesthesia with expected hospital stay \>4 days.

Brief summary: Our study is designed to evaluate the effect of intranasal insulin on postoperative cognitive dysfunction.

Primary outcome:

1. The occurrence of cognitive dysfunction at approximately 7 days after surgery.

Secondary outcome:

1. Incidence of any side effect.


Eligibility criteria: Inclusion Criteria:

1. Age 40 - 60 years.
2. Both gender.
3. Patients will be scheduled for elective major abdominal, thoracic, orthopedic, open gynecological, open urological, spine, otolaryngological surgeries under general anesthesia with expected hospital stay \>4 days.

Exclusion Criteria:

* 1. Drug allergy. 2. Patients with major psychiatric disease. 3. Patients receive major tranquillizers and antidepressant. 4. Those undergoing neurosurgery or cardiac surgery. 5. Those unable or unwilling to abide by the study procedure 6. Those who could not follow procedure or who had poor comprehension of dutch language. 7. Those with sever visual and auditory disorder / handicaps.

Primary outcomes:
measure: Cognitive dysfunction
timeFrame: 7 days
Secondary outcomes:
Other outcomes:
Locations:
city: Minya
country: Egypt
facility: Minia University
city: Minya
country: Egypt
facility: Minia university
Study officials:
References:
Clinical trial NCT01661049: Duodenal Cancer - Retrospective Analysis
Official title: 1997-2011 Duodenal Cancer Analysis in Southern Denmark
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Duodenal Cancer
Lead sponsor: Odense University Hospital
Sponsor class: OTHER
First posted: 2012-08-09
Enrollment: 55
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: RETROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Patients with duodenal cancer

Brief summary: To see how a cohorte of 55 patients over periode 1997-2011 were mannaged, treated and survived duodenal cancer. Also to see how advanced the tumors were at time of diagnose and at time of operation.


Eligibility criteria: Inclusion Criteria:

* duodenal cancer

Exclusion Criteria:

* other cancers of the upper GI tract such as pancreatic cancer,
* cholangiocarcinoma,
* papilla Vateri cancer

Primary outcomes:
Secondary outcomes:
Other outcomes:
Locations:
city: Odense
country: Denmark
facility: Thomas Buchbjerg
Study officials:
References:
Clinical trial NCT00579449: Evaluation of a Home Visiting Program for First Time Parents
Official title: Evaluation of a Home Visiting Program for First Time Parents
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Child Abuse
Keywords: child abuse
child neglect
Lead sponsor: Duke University
Sponsor class: OTHER
Collaborators: name: National Institute of Mental Health (NIMH)
name: The Duke Endowment
First posted: 2007-12-24
Enrollment: 343
Sex: FEMALE
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: PREVENTION

Brief summary: The purpose of this research is to evaluate the Healthy Families Durham (HFD) program by comparing the traditional 3-year program to 18-months of Healthy Families Durham to Yearly Visits with case management referrals to community services as usual, and to determine whether participation in the program reduces the number of reports for child maltreatment within the first seven years of the child's life.


Eligibility criteria: Inclusion Criteria:

* mother is a first-time parent (has been a primary caregiver of a child for less than 3 months total
* resident of Durham, North Carolina
* mother is being referred during pregnancy
* has at least one of the following risk factors: 16 years old or younger; lack of social support; history of substance abuse in the past 12 months; ever received treatment for alcohol or drug problems; history of domestic violence; history of being abused or neglected as a child; history of mental health problems in past 12 months; past child protective services involvement as a parent

Exclusion Criteria:

* actively suicidal or homicidal
* acutely psychotic
* moderately to severely mentally retarded

Primary outcomes:
measure: Durham County, North Carolina Department of Social Services reports of child maltreatment
timeFrame: 2011
Secondary outcomes:
Other outcomes:
Locations:
city: Durham
country: United States
facility: Center for Child and Family Health
state: North Carolina
Study officials:
affiliation: Duke University
name: Robert Murphy, Ph.D.
role: PRINCIPAL_INVESTIGATOR
affiliation: Duke University
name: Kenneth Dodge, Ph.D.
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT01113606: A Trial of Skin Care Protocols for Facial Resurfacing
Official title: A Double-Blind, Randomized, Controlled Trial to Assess the Effects of the Obagi Nu-Derm System on Re-Epithelialization After Chemical Peel or Ablative Laser Resurfacing.
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE4
Conditions: Facial Photo Damage
Periocular Fine Wrinkles
Perioral Fine Wrinkles
Keywords: Moderate to severe facial photo damage
Periocular or perioral fine wrinkles
Lead sponsor: The Plastic Surgery Foundation
Sponsor class: OTHER
First posted: 2010-04-30
Sex: FEMALE
Minimum age (years): 18
Maximum age (years): 65
Standard ages: ADULT
OLDER_ADULT

Brief summary: The aims of the Skin Product Assessment Research study were to (1) develop an infrastructure and process for industry-sponsored, Plastic Surgery Educational Foundation (PSEF) research in facial aesthetic surgery and (2) test the research process by comparing outcomes of the Obagi Nu-Derm System (ODNS) and conventional therapy as treatment adjuncts in ablative facial resurfacing.


Eligibility criteria: Inclusion Criteria:

* patients with moderate to severe photo damage and rhytids, undergoing full or partial face resurfacing with chemical peel or ablative laser.
* Fitzpatrick I-IV skin types

Exclusion Criteria:

* patients unable to complete the regimen or who had used topical prescription steroids, retinoids, depigmentation products or other products containing hydroquinone and polyhydroxy acids within 8 weeks of enrollment.

Primary outcomes:
Secondary outcomes:
Other outcomes:
Locations:
city: Oxnard
country: United States
facility: Suite 135
state: California
city: Rancho Santa Margarita
country: United States
facility: Suite 175
state: California
city: Greeley
country: United States
facility: Aesthetic and Plastic Surgery Institute
state: Colorado
city: Melbourne
country: United States
facility: Brevard Plastic Surgery and Skin Institute
state: Florida
city: Louisville
country: United States
facility: Kentucky Aesthetic and Plastic Surgery Institute
state: Kentucky
city: Ypsilanti
country: United States
facility: Center for Plastic and Reconstructive Surgery
state: Michigan
city: St. Louis
country: United States
facility: Body Aesthetic Plastic Surgery
state: Missouri
city: New York
country: United States
state: New York
city: Greenville
country: United States
facility: Advanced Cosmetis Surgery
state: South Carolina
Study officials:
References: