Clinical trial NCT06372366: Oral Manifestations in Egyptian Children With Short Stature
Official title: Oral Manifestations in Egyptian Children With Short Stature : A Cross Sectional Study
Study type: OBSERVATIONAL
Overall status: NOT_YET_RECRUITING
Conditions: Oral Manifestations
Short Stature
Lead sponsor: Cairo University
Sponsor class: OTHER
First posted: 2024-04-18
Enrollment: 2
Sex: ALL
Minimum age (years): 6
Maximum age (years): 12
Standard ages: CHILD
Accepts healthy volunteers: yes
Observational model: OTHER
Time perspective: CROSS_SECTIONAL
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Children aged from 6 to 12 years attending National Institute Of Diabetes And Endocrinology will be included in the study according to the following criteria:

Brief summary: Children with short stature have been reported to show a higher prevalence of enamel hypoplasia, delayed tooth eruption, and malocclusion compared to children of normal growth status

Detailed description: Normal growth is a process in which a single cell develops into a fully grown adult. The growth rate decelerates from the embryonic stage to adulthood, except during puberty. Most adults fall within a narrow range of stature, typically between 1.5 to 2 meters. Variations in height among children are largely determined by a set of genes inherited from their parents. These genes influence stature distribution within the normal range for nearly 95% of the population, with variation generally being benign.

Short stature in children-defined as a height-for-age below -2 standard deviations (SD) from the WHO growth reference-typically corresponding to the 2.3rd percentile, though many texts use the 3rd percentile as the cutoff. Short stature can be assessed using various anthropometric instruments. The condition may be physiological, with no abnormalities other than stature (polygenic short stature), or pathological, resulting from systemic illnesses, nutritional deficiencies, psychosocial factors, hormonal imbalances, genetic disorders, or musculoskeletal pathologies. A subset of infants born small for gestational age (SGA) may be at risk of persistent short stature.

Children with short stature have been reported to show a higher prevalence of enamel hypoplasia, delayed tooth eruption, and malocclusion compared to children of normal growth status . These oral manifestations may result from shared pathogenic mechanisms, such as nutritional deficits, systemic disturbances during enamel formation, or hormonal imbalances affecting growth and development. A clearer understanding of these associations may enhance multidisciplinary screening and care.

This study aims to investigate the prevalence and characteristics of oral manifestations in Egyptian children with short stature, contributing to the limited regional data on this topic.

Eligibility criteria: Inclusion Criteria:

* • - Egyptian children aged 6-12 years.
* - Diagnosed with short stature (height-for-age \< -2 SD based on WHO standards).
* - Diagnosed and confirmed by a pediatric endocrinologist.

Controls:

* - Age- and sex-matched children with normal height (height-for-age between -1 and +1 SD).
* - Recruited from the same geographic and socioeconomic backgrounds.

Exclusion Criteria:

* 1- Presence of syndromic conditions (e.g., Turner syndrome, Down syndrome).
* 2- Chronic diseases (e.g., renal, cardiac, or endocrine conditions other than idiopathic short stature).
* 3- Long-term medication use known to affect growth or oral development.

Primary outcomes:
measure: Dental enamel defects
timeFrame: 3 months
measure: Delayed dental eruption dental eruption Delayed dental eruption Delayed dental eruption
timeFrame: 3 months
measure: Malocclusion
timeFrame: 3 months
measure: plaque levels
timeFrame: 3 months
measure: Presence of salivary gland swelling or dryness
timeFrame: 3 months
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
References: