Clinical trial NCT04883216: Investigation of the Characteristics of Chronic Pain Developing After COVID-19
Official title: Investigation of the Characteristics of Chronic Pain Developing After COVID-19 in Patients With COVID-19
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Covid19
Coronavirus
Chronic Pain
Keywords: Chronic Pain
COVID19
Characteristics
Lead sponsor: Istanbul University
Sponsor class: OTHER
First posted: 2021-05-12
Enrollment: 776
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: CASE_ONLY
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: 1120 patients who had previously suffered from COVID-19 disease will be included in the study upon application to physical medicine and rehabilitation outpatient clinics with pain complaints developed after COVID-19.

Brief summary: Data on pain after COVID-19 were generally collected from hospitalized patients and only include information on acute pain conditions. However, the characteristics of the chronic pain experienced after COVID-19 are unknown. For this reason, the treatment and recommendations for patients who present with chronic pain after COVID-19 are not clear. Our goal is to determine the characteristics and risk factors of chronic pain developing in COVID-19 patients and to create specific treatment recommendations for these patient groups with further studies.

Detailed description: Data on pain developing after COVID-19 were generally collected from hospitalized patients and only include information on acute pain conditions seen after the ilness. It is noteworthy that headache and musculoskeletal pain were seen common in first few weeks. However, the characteristics (mechanical, inflammatory, central sensitization, anxiety-related, etc.) of the chronic pain experienced are unknown. For this reason, the treatment and recommendations for patients who present with chronic pain after COVID-19 are not clear. Our goal is to determine the characteristics and risk factors of chronic pain developing in COVID-19 patients and to create specific treatment recommendations for these patient groups with further studies.

Eligibility criteria: Inclusion Criteria:

1. Being over the age of 18
2. SARS-CoV-2 infection demonstrated with the PCR test (testing date irrelevant)
3. Pain developed or increased after having COVID-19

Exclusion Criteria:

1. Mental retardation or mental status not eligible to answer the questionnaires

Primary outcomes:
measure: Self-Leeds Assessment of Neuropathic Symptoms & Signs (S-LANSS) Pain Score
timeFrame: up to 1 year
measure: The Hospital Anxiety and Depression Scale (HADS) Score
timeFrame: up to 1 year
measure: Central Sensitization Inventory (CSI)
timeFrame: up to 1 year
measure: Self-report Demographic Questionnaire
timeFrame: up to 1 year
measure: Visual Analog Scale (VAS) for Pain
timeFrame: up to 1 year
Secondary outcomes:
Other outcomes:
Locations:
city: İstanbul
country: Turkey
facility: Istanbul University Istanbul Faculty of Medicine
Study officials:
affiliation: Professor
name: Ayşegül Ketenci, Professor
role: STUDY_DIRECTOR
affiliation: MD
name: Mert Zure, Expert
role: PRINCIPAL_INVESTIGATOR
References:
citation: Weng LM, Su X, Wang XQ. Pain Symptoms in Patients with Coronavirus Disease (COVID-19): A Literature Review. J Pain Res. 2021 Jan 26;14:147-159. doi: 10.2147/JPR.S269206. eCollection 2021.
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