louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT04453215: Laser Therapy for Patients With Systemic Lupus Erythematosus
Official title: The Effect of Dental Laser Therapy for Patients With Systemic Lupus Erythematosus
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Systemic Lupus Erythematosus
Muscle Pain
Chewing Function
Lead sponsor: Istanbul University
Sponsor class: OTHER
First posted: 2020-07-01
Enrollment: 91
Sex: ALL
Minimum age (years): 18
Maximum age (years): 65
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: Systemic lupus erythematosus (SLE) is a chronic, autoimmune disease that has detrimental effects on connective tissue and other organs. The musculoskeletal system is one of the most affected systems in this group of patients including the temporomandibular joint. The most common symptoms when muscle involvement in SLE are muscle atrophy decreased muscle strength and myopathy. SLE activity and long-term corticosteroid use are thought to be responsible for these symptoms, thus, SLE patients are accepted to be at higher risk for temporomandibular joint disorders (TMD). Low-level laser therapy(LLLT) is frequently used in the treatment of TMD due to its pain relief and anti-inflammatory effect. Thus, in this study, LLLT has been used to evaluate this treatment modality on the chewing function and pain values of SLE patients with myogenic TMD.


Eligibility criteria: Inclusion Criteria:

* Having myogenic temporomandibular joint disorder,
* Following a stable medical regime,
* Showing minimum pain intensity of 50 mm on the visual analog scale.

Exclusion Criteria:

* Having concurrent systemic diseases,
* Using antimalarial drugs,
* Wearing removable prosthesis,
* History of facial trauma.

Primary outcomes:
measure: pain value
timeFrame: 2 months
measure: chewing function
timeFrame: 2 months
Secondary outcomes:
Other outcomes:
Locations:
city: Fatih
country: Turkey
facility: Istanbul university,Faculty of Dentistry
Study officials:
affiliation: Assistant Professor
name: merve benli, PhD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT01988415: New Treatment Algorithm to Reduce Spherical Aberration After LASIK Correction for Myopia
Official title: A Prospective Study to Evaluate the Feasibility of a New Treatment Algorithm for Wavefront-Guided Lasik Correction of Myopic Refractive Errors
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Myopia
Astigmatism
Lead sponsor: Abbott Medical Optics
Sponsor class: INDUSTRY
First posted: 2013-11-20
Enrollment: 26
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: TREATMENT

Brief summary: The purpose of this clinical trial is to demonstrate that treatments generated by an investigational algorithm reduces spherical aberration compared to currently available iDesign treatments.

Detailed description: Post-LASIK induction of spherical aberration is currently among the most prominent challenges for refractive surgery. The presence of significant spherical aberration in the visual system results in reduced contrast sensitivity, visual symptoms such as "glare" and "halos," and "night myopia" or the induction of myopia under low lighting (larger pupil size). A modified Treatment Planning Software (TPS) "VSS-Rx1 OPM software" has been developed that uses a modified algorithm (software that designs the LASIK treatment profile) to limit the induction of postoperative spherical aberration. Commercially available software used to calculate the LASIK treatment profile was used in one eye (active comparator \[i.e., control\]) and VSS-Rx1 OPM software was used in the fellow eye (experimental). Subjects were masked to the use of either the commercially available or VSS-Rx1 OPM software.

Eligibility criteria: Inclusion Criteria:

* Male or female at least 18 years of age at the time of preoperative exam
* Best Spectacle Corrected Visual Acuity (BSCVA) of 20/20 or better
* Demonstration of refractive stability
* Anticipated postoperative stromal bed thickness of at least 250 microns
* Willing and able to return for all study examinations

Exclusion Criteria:

* Pregnant, breast-feeding, or intend to become pregnant over the course of the study
* Concurrent use of topical or systemic medications that may impair healing
* History of prior intraocular or corneal surgery, active ophthalmic disease, or other ocular abnormality
* Evidence of keratoconus, corneal irregularity, or abnormal topography in the operative eye(s)
* Known sensitivity or inappropriate responsiveness to any of the medications used in the postoperative course

Primary outcomes:
measure: Mean Postoperative Spherical Aberration
timeFrame: 3 months
measure: Percentage of Eyes Losing More Than 2 Lines of Best-corrected Distance Visual Acuity
timeFrame: 3 Months
Secondary outcomes:
Other outcomes:
Locations:
city: Bogota Laser, Bogota
country: Colombia
facility: Gustavo Tamayo, M.D.
Study officials:
affiliation: Medico Oftalmologo
name: Gustavo Tamayo, M.D.
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT06698315: Evidence-based Approach to Reduce Falls in Adult Patients
Official title: Tailored Interventions for Patient Safety: an Evidence-based Approach to Reduce Falls in Adult Patients
Study type: OBSERVATIONAL
Overall status: RECRUITING
Conditions: Falls with Injuries
Lead sponsor: Methodist Health System
Sponsor class: OTHER
First posted: 2024-11-20
Enrollment: 1000
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: OTHER
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Patients with psychiatric conditions and cognitive impairments will be excluded from the project. This assessment is routine.

Brief summary: The project aims to promote patient safety and quality care by reducing preventable falls and falls with injuries using an evidence-based solution.

Detailed description: The project aims to promote patient safety and quality care by reducing preventable falls and falls with injuries using an evidence-based solution: the Fall Tailoring Interventions for Patient Safety (TIPS) intervention. The three objectives include: (a) developing personalized fall prevention interventions for high-risk patients, (b) engaging patients and families in fall prevention initiatives, and (c) promoting effective communication among teams using a bedside visual tool.

Eligibility criteria: Inclusion Criteria:

* Adult (≥18 years) inpatients admitted for various medical-surgical conditions in 3 Medical unit at MRMC. All patients will be included in the project except those diagnosed with psychiatric conditions and cognitive impairments.

Exclusion Criteria:

* Patients with psychiatric conditions and cognitive impairments will be excluded from the project. This assessment is routine.

Primary outcomes:
measure: Determine if the Fall TIPS initiative is effective at reducing falls at MRMC.
timeFrame: through study completion, up to 18 months
Secondary outcomes:
Other outcomes:
Locations:
city: Dallas
country: United States
facility: Methodist Dallas Medical Center- Clinical Research Institute
state: Texas
Study officials:
affiliation: METHODIST RICHARDSON MEDICAL CENTER
name: ELIZABETH D AARON, MSN
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT00991315: Collecting and Storing Blood and Tumor Tissue Samples From Patients Undergoing Prostatectomy or Transurethral Resection of the Prostate
Official title: Assessment of Tumor Resistance and Stem Cells in Prostate Cancer
Study type: OBSERVATIONAL
Overall status: TERMINATED
Conditions: Prostate Cancer
Keywords: prostate cancer
Lead sponsor: Rutgers, The State University of New Jersey
Sponsor class: OTHER
Collaborators: name: National Cancer Institute (NCI)
name: Rutgers Cancer Institute of New Jersey
First posted: 2009-10-08
Enrollment: 126
Sex: MALE
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: CASE_ONLY
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Any patient undergoing a routine prostatectomy or TURP (transurethral resection of the prostate) may be asked to participate

Brief summary: The primary objective of this study is to collect material for study's to assess mechanisms of tumor progression, mechanisms of resistance, isolation of stem cells and biologic markers in tissue, serum and peripheral blood mononuclear cells.


Eligibility criteria: DISEASE CHARACTERISTICS:

* Undergoing routine prostatectomy or transurethral resection of the prostate (TURP)

PATIENT CHARACTERISTICS:

5.1.1 Patient is undergoing routine prostatectomy or TURP.

5.1.2 Patient is ≥ 18 years old.

5.1.3 Patient must give informed consent.

PRIOR CONCURRENT THERAPY:

* See Disease Characteristics

Primary outcomes:
measure: Collection and freezing of tumor samples
timeFrame: 5 years
Secondary outcomes:
Other outcomes:
Locations:
city: New Brunswick
country: United States
facility: Rutgers Cancer Institute of New Jersey
state: New Jersey
Study officials:
affiliation: Rutgers Cancer Institute of New Jersey
name: Isaac Kim, MD, PhD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT04480515: Does COVID-19 Pandemic Reduce In-hospital Mortality?
Official title: Does COVID-19 Pandemic Reduce In-hospital Mortality?
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Covid19
In-hospital Cardiac Arrest
Lead sponsor: Kanuni Sultan Suleyman Training and Research Hospital
Sponsor class: OTHER
First posted: 2020-07-21
Enrollment: 5000
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: OTHER
Sampling method: NON_PROBABILITY_SAMPLE
Study population: All the records of in-hospital mortality will be evaluated

Brief summary: COVID-19, which emerged in China in December 2019, has become a pandemic with its spread to many countries of the world. Although it is suggested that hospital admissions are reduced due to some reasons such as trauma, during COVID-19 pandemic, it is controversial whether in-hospital mortality rates changed. Therefore this multi-centered study aimed to determine how in-hospital mortality effected during the pandemic period according to the specific patient groups.

Detailed description: COVID-19, which emerged in China in December 2019, has become a pandemic with its spread to many countries of the world. Although it is suggested that hospital admissions are reduced due to some reasons such as trauma, during COVID-19 pandemic, it is controversial whether in-hospital mortality rates changed. Therefore this multi-centered study aimed to determine how in-hospital mortality effected during the pandemic period according to the specific patient groups. Thus, in case of a pandemic, it will be a guide in which patient groups healthcare providers should be more careful about.

Eligibility criteria: Inclusion Criteria:

* Deaths, with all required data available, occurred within the study hospitals
* centers Accepted to participate with an informed consent

Exclusion Criteria:

* lack of consent
* lack of data
* deaths occurred outside the study hospitals

Primary outcomes:
measure: In-hospital mortality
timeFrame: 4 months
Secondary outcomes:
Other outcomes:
Locations:
city: Istanbul
country: Turkey
facility: Kanuni Sultan Suleyman Training and Research Hospital
Study officials:
References:
Clinical trial NCT02685215: Prognostic Factors , Morbidity and Mortality in Patients With Neuromuscular Disorders Admitted in ICU
Official title: Prognostic Factors, Morbidity, Mortality and Long Term Survival in Patients With Neuromuscular Disorders Admitted in Intensive Care Unit
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Muscular Dystrophies
Intensive Care (ICU) Myopathy
Keywords: intensive care unit
muscular dystrophy
mortality
prognosis
tracheostomy
Lead sponsor: Centre d'Investigation Clinique et Technologique 805
Sponsor class: OTHER
First posted: 2016-02-18
Enrollment: 800
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: CASE_CONTROL
Time perspective: RETROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: All patients with neuro-muscular disorders admitted in ICU since 2005

Brief summary: Muscular dystrophies are neuromuscular disorders with disability. Restrictive pulmonary failure and cardiomyopathy affect prognosis.The investigators aim to establish predictive factors for mortality and morbidity in Intensive care unit (ICU ) and to describe the long term follow up after ICU discharge.

Detailed description: Muscular dystrophies are neuromuscular disorders with disability. Restrictive pulmonary failure and cardiomyopathy affect prognosis. Little is known about morbidity and mortality of patients with muscular dystrophies admitted in intensive care unit (ICU).The investigators aim to describe the spectrum of patients with muscular dystrophies admitted in ICU , to establish predictive factors for ICU mortality and morbidity and to describe the long term follow up after ICU discharge.

Eligibility criteria: Inclusion Criteria:

* admitted in ICU
* Duchenne muscular dystrophy
* Becker muscular dystrophy
* LGMD
* Steinert disease
* Pompe disease
* FSHD
* metabolic disease
* mitochondrial disease
* congenital myopathy
* others neuro-muscular diseases

Exclusion Criteria:

* brain injury
* minor patient

Primary outcomes:
measure: ICU mortality
timeFrame: 1 month
Secondary outcomes:
measure: tracheostomy in ICU
timeFrame: 1 month
measure: predictive factors for re admission in ICU
timeFrame: 1 year
measure: long term survival after ICU stay
timeFrame: 5 years
measure: decline of vital capacity after ICU stay
timeFrame: 2 years
Other outcomes:
Locations:
city: Garches
country: France
facility: Hopital Raymond Poincare
Study officials:
affiliation: Raymond Poincare Hospital
name: abdallah Fayssoil, MDPhD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT03691415: Evaluation of the Safety and Effectiveness of BELKYRA® Inj. for the Treatment of Patients With Submental Fullness Due to Submental Fat: A Postmarketing Surveillance Study in Korea
Official title: Evaluation of the Safety and Effectiveness of BELKYRA® Inj. for the Treatment of Patients With Submental Fullness Due to Submental Fat: A Post Marketing Surveillance Study in Korea
Study type: OBSERVATIONAL
Overall status: TERMINATED
Conditions: Submental Fullness
Keywords: Double Chin Fat Reduction
Lead sponsor: Allergan
Sponsor class: INDUSTRY
First posted: 2018-10-01
Enrollment: 71
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: This study will include adult patient is an adult (≥ 18 years of age) in South Korea treated with BELKYRA for the improvement of moderate to severe convexity or fullness associated with submental fat in adults

Brief summary: The purpose of this PMS study is to evaluate the safety and effectiveness of BELKYRA Inj. used according to the dose specified in the instructions for use, for the treatment of patients with SM fullness due to SMF, through active investigation under routine clinical practice


Eligibility criteria: Inclusion Criteria:

* Eligible and consenting Korean patients
* Patients who have consented to the study and who have signed the private information protection act form or ICF

Exclusion Criteria:

* Patients having infection at the infection sites
* Patients presenting evidence of causes of enlarged submental area other than localized submental fat (E.g.: thyroid enlargement, enlarged submental salivary glands, cervical lymphadenopathy, etc.)
* Patients participating in an interventional clinical study, currently or within 30 days before enrollment, will not be eligible for inclusion in the study
* Pregnant women
* Renal impairment patients
* Hepatic impairment patients
* Patients with severe laxity

Primary outcomes:
measure: Change from baseline in Clinician-Reported Submental Fat Rating Scale (CR-SMFRS)
timeFrame: Baseline, Follow up visit (within 3 months of injection)
measure: Change from baseline in Patient-Reported Submental Fat Rating Scale (PR-SMFRS)
timeFrame: Baseline, Follow up visit (within 3 months of injection)
Secondary outcomes:
Other outcomes:
Locations:
city: Daejeon
country: Korea, Republic of
facility: Oracle-Dermatology
city: Seoul
country: Korea, Republic of
facility: Goldenview plastic surgery
city: Seoul
country: Korea, Republic of
facility: (Apgujeong) Oracle-Dermatology
city: Seoul
country: Korea, Republic of
facility: Dream-Dermatology
Study officials:
affiliation: Allergan
name: Suzanne St. Rose, DVM, MSc, PhD
role: STUDY_DIRECTOR
References:
Clinical trial NCT01481415: Left Atrial Volume and Function in Children Assessed by Echo 3DRT: Reference Values for Normal Children
Official title: Left Atrial Volume and Function in Healthy Children Assessed by Three Dimensional Echocardiography
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Left Ventricular Function Good
Keywords: left atrial
three-dimensional echocardioraphy
left atrial function
Lead sponsor: Hospital Israelita Albert Einstein
Sponsor class: OTHER
Collaborators: name: University of Sao Paulo
First posted: 2011-11-29
Enrollment: 145
Sex: ALL
Minimum age (years): 3
Maximum age (years): 13
Standard ages: CHILD
Accepts healthy volunteers: yes
Time perspective: RETROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: community sample

Brief summary: The investigators study is trying to find the normal value to left atrial volume and left atrial function in healthy children by tridimensional real time echocardiography avaluation.


Eligibility criteria: Inclusion Criteria:

* research murmur

Exclusion Criteria:

* any congenital heart disease
* any systemic disease

Primary outcomes:
Secondary outcomes:
Other outcomes:
Locations:
city: Sâo Paulo
country: Brazil
facility: Hospital Israelita Albert Einstein
state: Sao Pauo
city: São Paulo
country: Brazil
facility: Hospital Israelita Albert Einstein
Study officials:
affiliation: Sociedade Beneficente Israelita Albert Einstein
name: Laise Antonia Bonfim Guimaraes, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT02795715: tDCS Effects on Associative Learning in Younger Adults
Official title: Effects of Transcranial Direct Current Stimulation (tDCS) on Associative Learning in Young Adults
Study type: INTERVENTIONAL
Overall status: WITHDRAWN
Phase: NA
Conditions: Associative Learning
Keywords: tDCS
Lead sponsor: Charite University, Berlin, Germany
Sponsor class: OTHER
First posted: 2016-06-10
Enrollment: 0
Sex: ALL
Minimum age (years): 18
Maximum age (years): 30
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: CROSSOVER
Primary purpose: TREATMENT

Brief summary: The aim of this study is to investigate whether a tDCS-accompanied training of audio-visual associative memory leads to a performance improvement in healthy older individuals."


Eligibility criteria: Inclusion Criteria:

* Age: young (18-30 years)
* Right handedness
* unobtrusive neuropsychological screening

Exclusion Criteria:

* Mild cognitive impairment (MCI) or other neurological diseases.
* History of severe alcoholism or use of drugs.
* Severe psychiatric disorders such as depression, psychosis (if not in remission) and severe untreated medical problems.
* Contraindication for MRI (claustrophobia, metallic implants, ferromagnetic metals in the body, disorders of thermoregulation, pregnant women).

Primary outcomes:
measure: Performance in a verbal associative learning paradigm under anodal tDCS compared to sham tDCS.
timeFrame: assessed immediately after training period (several learning blocks) compared to sham
Secondary outcomes:
measure: Functional connectivity predictors
timeFrame: assessed during baseline testing
measure: Structural predictors
timeFrame: assessed during baseline testing
measure: Genotyping of learning related polymorphisms
timeFrame: assessed during baseline screening
measure: Other cognitive outcomes: Attention performance
timeFrame: assessed directly before and immediately after tDCS + training compared to sham
measure: Other cognitive outcomes: working memory performance
timeFrame: assessed directly before and immediately after tDCS + training compared to sham
Other outcomes:
Locations:
city: Berlin
country: Germany
facility: Charité Universitätsmedizin Berlin
Study officials:
affiliation: Charite University, Berlin, Germany
name: Agnes Flöel, Prof. Dr.
role: PRINCIPAL_INVESTIGATOR
References:
citation: Floel A, Rosser N, Michka O, Knecht S, Breitenstein C. Noninvasive brain stimulation improves language learning. J Cogn Neurosci. 2008 Aug;20(8):1415-22. doi: 10.1162/jocn.2008.20098.
citation: Breitenstein C, Knecht S. Development and validation of a language learning model for behavioral and functional-imaging studies. J Neurosci Methods. 2002 Mar 15;114(2):173-9. doi: 10.1016/s0165-0270(01)00525-8.
citation: Breitenstein C, Jansen A, Deppe M, Foerster AF, Sommer J, Wolbers T, Knecht S. Hippocampus activity differentiates good from poor learners of a novel lexicon. Neuroimage. 2005 Apr 15;25(3):958-68. doi: 10.1016/j.neuroimage.2004.12.019.