Clinical trial NCT01325675: Aerobic Interval Training in Patients With Atrial Fibrillation
Official title: Aerobic Interval Training in Patients With Paroxysmal or Persistent Atrial Fibrillation
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Atrial Fibrillation
Keywords: Atrial fibrillation
Motor activity
Lead sponsor: Norwegian University of Science and Technology
Sponsor class: OTHER
Collaborators: name: St. Olavs Hospital
name: SINTEF Health Research
First posted: 2011-03-30
Enrollment: 51
Sex: ALL
Minimum age (years): 18
Maximum age (years): 90
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: PREVENTION

Brief summary: The purpose of this study is to determine the effect of aerobic interval training in patients with paroxysmal or persistent atrial fibrillation, especially to see if the burden of atrial fibrillation and symptoms are reduced.

Detailed description: Long term endurance sport practice is associated with a higher incidence of atrial fibrillation. Moderate/light physical activity seems to be associated with a lower incidence. The underlying mechanisms are uncertain. In order to examine the effect of training in this population, the investigators will perform a randomised controlled study with aerobic interval training in patients with paroxysmal/persistent atrial fibrillation.

Eligibility criteria: Inclusion Criteria:

* Patients with paroxysmal or persistent atrial fibrillation, that are able to perform aerobic interval training.

Exclusion Criteria:

* Performing high intensity training (pulse \>90% of max) for more than 2 times a week.
* Moderate intensity training more than 30 min, more than 3 times a week
* Previous open heart surgery
* EF \<40%
* Significant aorta stenosis
* Mitral insufficiency, \>gr. 2
* Pacemaker
* Earlier coronary intervention and not complete revascularization

Primary outcomes:
measure: Change in burden of atrial fibrillation
timeFrame: Baseline and 4 weeks after ended intervention period
Secondary outcomes:
measure: Size of left atrium and ventricle
timeFrame: Baseline and after ended intervention period(12 weeks)
measure: Blood samples
timeFrame: Baseline and after ended intervention period(12 weeks)
measure: Endothelial function
timeFrame: Baseline and after ended intervention period(12 weeks)
measure: Atrial extrasystoles
timeFrame: Baseline and after ended intervention period(12 weeks)
measure: Ablation procedure
timeFrame: Measured during the ablation procedure (day 1)
measure: Maximal oxygen uptake
timeFrame: Baseline and after ended intervention period(12 weeks)
measure: Atrial and ventricular function
timeFrame: Baseline and after ended intervention period(12 weeks)
measure: Fibrosis
timeFrame: Baseline and after ended intervention period(12 weeks)
measure: Quality of life
timeFrame: Baseline and after ended intervention period(12 weeks)
measure: Burden of atrial fibrillation in the intervention period
timeFrame: Week 1-4, 5-8 and 9-12
Other outcomes:
Locations:
city: Trondheim
country: Norway
facility: Norwegian University of Science and Technology
Study officials:
affiliation: St. Olavs Hospital
name: Jan Paal Loennechen, PhD
role: STUDY_CHAIR
affiliation: Norwegian University of Science and Technology
name: Ulrik Wisløff, PhD
role: STUDY_CHAIR
References:
citation: Malmo V, Nes BM, Amundsen BH, Tjonna AE, Stoylen A, Rossvoll O, Wisloff U, Loennechen JP. Aerobic Interval Training Reduces the Burden of Atrial Fibrillation in the Short Term: A Randomized Trial. Circulation. 2016 Feb 2;133(5):466-73. doi: 10.1161/CIRCULATIONAHA.115.018220. Epub 2016 Jan 5.