Clinical trial NCT02008019: A Phase II Study of EVEROLIMUS in Patients With Primary or Relapsed Chondrosarcomas
Official title: A Randomized Prospective, Multicentric, Open Label, Phase II Study Aiming to Evaluate the Efficacity and Safety of EVEROLIMUS as Neo-adjuvant Therapy in Patients With Primary or Relapsed Chondrosarcomas
Study type: INTERVENTIONAL
Overall status: SUSPENDED
Phase: PHASE2
Conditions: Chondrosarcoma
Keywords: Chondrosarcoma
Neoadjuvant therapy
Phase II
Everolimus
Success Rate
Progression Free Survival
Overall Survival
Safety
Quality of Life
Molecular study (ancillary study)
Lead sponsor: Centre Leon Berard
Sponsor class: OTHER
First posted: 2013-12-11
Enrollment: 57
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The mainstay of chondrosarcoma treatment is a wide surgical resection. Unfortunately, this is a rare occurrence, and patients with incomplete resection have very poor therapeutic options. In this context, it becomes important to find new therapeutic strategies to slow down tumor progression and to reduce tumor size before resection.

Pre-clinical and clinical data suggest that EVEROLIMUS should be efficient as adjuvant and neo-adjuvant therapy in chondrosarcoma.

Then, investigators propose a phase II, randomized, open label study compounded by 3 arms (1:1:1) to assess efficiency of EVEROLIMUS as neo-adjuvant therapy in patients with primary or relapsed chondrosarcomas :

ARM 1 = No treatment; ARM 2 = 2,5 mg Everolimus/day; ARM 3 = 10 mg Everolimus/day.

The treatments will be taken for 4 weeks before surgery, apart from any premature withdrawn

Detailed description: Chondrosarcomas (CHS) represent 25% of bone sarcomas and are the second most frequent primary malignant type of bone tumor. No effective systemic treatment has been identified in advanced or adjuvant phases for CHS. As CHS are relatively resistant to chemo- and radiotherapy, surgery remains the primary treatment of this tumor type. The aim of tumor resection is to obtain complete removal of the malignant lesion with adequate margins taking into account tumor control and functional reconstruction. However, considering the particular localizations of CHS, a wide resection (i.e. R0 clear margins) is rarely achieved. Unfortunately, therapeutic options are limited for patients with incomplete resection. In this context, new therapeutic strategies are needed to slow down tumor progression and to reduce tumor size before surgery.

Increasing knowledge of the signal transduction pathways involved in oncogenesis has led to speculation that components of signalling pathways could be envisaged as novel targets for cancer therapy. Mammalian Target of Rapamycin (mTOR), which lies downstream of the Phosphatidylinositol 3-kinase/B kinase protein (PI3K/Akt) pathway, plays a central role in the regulation of cancer cell growth, suggesting that mTOR could be an attractive target for anti-cancer therapy. The PI3K-Akt-mTOR signaling pathway is intimately implicated in sarcoma development and progression. Indeed, mutations and/ or overexpression of one or several components of the PI3K-Akt-mTOR pathway are often observed in sarcoma. These alterations, located both upstream and downstream of mTOR, lead to dysregulation of the mTOR pathway. mTOR inhibitor evaluation as anticancer agents has began with rapamycin analogues (called rapalogs). Currently, mTOR inhibitors under clinical development include temsirolimus (CCI-779, Torisel®, Wyeth Pharmaceuticals), everolimus (RAD001, Afinitor®, Novartis Pharmaceuticals), and ridaforolimus (AP23573, ARIAD Pharmaceuticals). mTOR inhibitors were found to be efficient in various preclinical cancer models, for example in a preclinical mouse model of follicular thyroid cancer, everolimus induced a significant decrease in proliferation of cancer cells.

Two sets of recent data suggest that inhibition of mTOR pathway could be an effective systemic treatment for chondrosarcoma. The first one is a case report describing an impressive tumor response in a patient with myxoid chondrosarcoma treated by rapamycin in combination with cyclophosphamide. The second one concerns nonclinical data generated by our institution. Using an orthotopic rat chondrosarcoma model, we have shown that monotherapy with everolimus inhibits chondrosarcoma proliferation as evaluated by Ki67 expression and significantly reduced tumor volume. Importantly, when given in a "pseudo-adjuvant" setting following R1 resection of the implanted tumor, everolimus significantly delayed tumor recurrence. These preclinical data provide a strong rationale to evaluate the therapeutic potential of everolimus in both the neo-adjuvant and adjuvant settings in patients with chondrosarcoma.

In this context, the proposal of the investigators is to perform a multicenter, randomized, Phase II study in patients with a primary or relapsed chondrosarcoma in neo-adjuvant setting

Eligibility criteria: INCLUSION CRITERIA :

* Male or Female ≥ 18 years
* Histopathologically confirmed diagnosis of primary or relapsed conventional CHS of the bone (with or without metastases), CHS of any size on MRI if relapse OR size ≥ 10 cm on MRI at diagnosis OR CHS \< 10 cm if R0 resection with adequate margins is not feasible at 1st examination (localization, tumor infiltration within surrounding tissues).
* Patient with life expectancy \> 6 months
* Planned surgery between D32- D40 after inclusion
* Performance status of Eastern Cooperative Oncology Group (ECOG) ≤ 2
* No contra-indication to Everolimus as per Summary of Product Characteristics (SPC)
* Adequate bone marrow, liver and renal functions including the following:

  * Hemoglobin \> 9 g/dL
  * Neutrophil count ≥ 1500 x 109/L
  * Platelets ≥ 100 x 109/L
  * Total bilirubin ≤ 1,5x upper limit of normal (ULN)
  * Serum Glutamate Oxaloacetate Transaminase (SGOT) and Serum Glutamate Pyruvate Transaminase (SGPT) ≤ 3 x ULN
  * Alkaline Phosphatase ≤ 2,5 x ULN
  * Serum creatinine \< 110 µmol/L or creatinine clearance \> 55 ml/min (estimated by Cockcroft Formula)
* Fasting serum cholesterol ≤300 mg/dL OR ≤7.75 mmol/L AND fasting triglycerides ≤ 2.5 x ULN. NOTE: In case one or both of these thresholds are exceeded, the patient can only be included after initiation of appropriate lipid lowering medication.
* Ability to understand and willingness to sign a written informed consent
* In accordance with French Regulatory Authorities: Patients with French Social Security in compliance with the French law relating to biomedical research (Huriet Law 88-1128 and related decrees)
* Women of child-bearing potential and men must agree to use adequate double contraception prior to study entry, for the duration of study participation and 30 days after the last study drug intake.

EXCLUSION CRITERIA :

* Mesenchymal, dedifferentiated, clear cell subtype chondrosarcoma, and soft tissues chondrosarcoma
* Tumor tissue sample not available for pathological review/or correlative studies
* Patients may not be receiving any other investigational agents
* Prior treatment with mTOR inhibitors
* Symptomatic congestive heart failure of New York heart Association Class III or IV
* Uncontrolled diabetes as defined by fasting serum glucose \>160 mg/dl or 8.9 mmol/l
* Unstable angina pectoris, symptomatic congestive heart failure, myocardial infarction within 6 months of start of study drug, serious uncontrolled cardiac arrhythmia or any other clinically significant cardiac disease
* Chemotherapy within the last 4 weeks before inclusion; radiotherapy, or any other investigational agent within 14 days or 5 half-lives, whichever is longer prior to the first dose of study drug
* Any concurrent severe and/or uncontrolled medical conditions which could compromise participation in the study
* Impaired cardiac function or clinically significant cardiac diseases, or liver, respiratory or hepatic disease
* Known diagnosis of HIV infection
* Patient with ongoing toxicity Grade ≥ 2 according to the NCI Common Toxicity Criteria for Adverse Effects (CTCAE) V4.0
* Pregnant or breast feeding women (a pregnancy test will be performed within 7 days before inclusion).

Primary outcomes:
measure: Success Rate obtained per arm
timeFrame: 4 weeks after inclusion
Secondary outcomes:
measure: Progression-Free Survival (PFS)
timeFrame: At time of progression in the course of the 3 years follow up after randomization
measure: Safety
timeFrame: In the course of the 3 years after randomization
measure: Overall Survival
timeFrame: At time of death if occuring during the 3 years of follow up after randomization
measure: Quality of Life
timeFrame: From randomization to the end of the 3 years follow up
Other outcomes:
Locations:
city: Bordeaux
country: France
facility: Institut Bergonié
state: Gironde
city: Toulouse
country: France
facility: Institut Claudius Regaud
state: Haute Garonne
city: Limoges
country: France
facility: Centre Hospitalier Universitaire de Limoges, Hôpital Dupuytren
state: Haute Vienne
city: Montpellier
country: France
facility: Institut Régional du Cancer de Montpellier
state: Hérault
city: Tours
country: France
facility: Centre Hospitalier Régional Universitaire de Tours, Hôpital Trousseau
state: Indre et Loire
city: Nantes
country: France
facility: Centre Hospitalier Universitaire de Nantes, Hôtel Dieu
state: Loire Atlantique
city: Saint-Herblain
country: France
facility: Institut de Cancérologie de l'Ouest - René Gauducheau
state: Loire Atlantique
city: Vandoeuvre-les-Nancy
country: France
facility: Institut de Cancérologie de Lorraine
state: Meurthe et Moselle
city: Lille
country: France
facility: Centre Oscar Lambret
state: Nord
city: Lille
country: France
facility: CHRU de Lille - Hôpital Roger Salengro
state: Nord
city: Lyon
country: France
facility: Centre Léon Bérard
state: Rhône
city: Villejuif
country: France
facility: Institut Gustave Roussy
state: Val de Marne
Study officials:
affiliation: Centre Léon Bérard, Lyon
name: Jean-Yves Blay, Professor
role: PRINCIPAL_INVESTIGATOR
affiliation: Centre Hospitalier Universitaire de Nantes, Hôtel Dieu
name: François Gouin, Professor
role: PRINCIPAL_INVESTIGATOR
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