louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT06320873: The Effect of Respiratory on Sports Performance in Archers
Official title: The Effect of Pulmonary Functions and Respiratory Muscle Strength on Sports Performance in Elite Archers
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Sports Physical Therapy
Lead sponsor: Halic University
Sponsor class: OTHER
First posted: 2024-03-20
Enrollment: 46
Sex: ALL
Minimum age (years): 18
Maximum age (years): 30
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: OTHER

Brief summary: Purpose: The physical, physiological, and functional characteristics of archers affect target shooting performance. In our study, we aimed to examine the effect of pulmonary functions and respiratory muscle strength on sports performance in archers.

Methods: Our study included 46 (27 female, 19 male) professional archers registered in archery sports clubs. Sociodemographic and physical characteristics were recorded. Pulmonary function test (PFT), respiratory muscle strength, shooting performance test, Moberg-pickup collection test, Nelson hand reaction test, and Fatigue Severity Scale (FSS) were applied to all participants.


Eligibility criteria: Inclusion Criteria:

* Between 18-30 years old,
* Professional archers.

Exclusion Criteria:

* Participants who had COVID-19 (Coronavirus Disease) in the last 2 months,
* Musculoskeletal disorders,
* Orthopedic surgery,
* Smoking history,
* Neurologic and pulmonary diseases.

Primary outcomes:
measure: FEV1 (liter)
timeFrame: at the enrollment
measure: FEV1 (%-percentage)
timeFrame: at the enrollment
measure: FVC (liter)
timeFrame: at the enrollment
measure: FVC (%-percentage)
timeFrame: 7 months
measure: FEV1/FVC (percentage)
timeFrame: at the enrollment
measure: Inspiratory muscle test
timeFrame: at the enrollment
measure: Expiratory muscle test
timeFrame: at the enrollment
measure: Shooting performance
timeFrame: at the enrollment
measure: Nelson Hand Reaction Test
timeFrame: at the enrollment
measure: Moberg-pickup collection test
timeFrame: at the enrollment
measure: The Fatigue Severity Scale (FSS)
timeFrame: at the enrollment
Secondary outcomes:
Other outcomes:
Locations:
city: Istanbul
country: Turkey
facility: Halic University
Study officials:
References:
Clinical trial NCT00842231: Assessment of Visual Performance in Patients With Low Levels of Astigmatism
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Cataract Extraction
Corneal Astigmatism
Keywords: Corneal astigmatism
post-cataract surgery
visual performance
Corneal astigmatism 0.5-0.75 Diopter
Lead sponsor: Alcon Research
Sponsor class: INDUSTRY
First posted: 2009-02-12
Enrollment: 40
Sex: ALL
Minimum age (years): 50
Maximum age (years): 75
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Subjects were selected from a single investigator's primary care clinic.

Brief summary: To assess visual performance in patients with low levels (0.5-0.75 Diopters) of corneal astigmatism.


Eligibility criteria: Inclusion Criteria:

* 50-75 years of age
* Proof of eye exam within the last 12 months
* Operated for uncomplicated, age-related cataracts \>3 months
* Corneal astigmatism of 0.5-0.75 diopter

Exclusion Criteria:

* Previous ocular or refractive surgery/trauma
* Clinically severe corneal dystrophy
* Amblyopia
* Degenerative visual disorders

Primary outcomes:
measure: High and Low Contrast Acuity
timeFrame: Day of study visit
measure: Contrast Sensitivity
timeFrame: Day of Study Visit
measure: Reading Acuity and Speed
timeFrame: Day of Study Visit
Secondary outcomes:
Other outcomes:
Locations:
city: Fort Worth
country: United States
facility: Contact Alcon Call Center For Trial Locations
state: Texas
Study officials:
References:
Clinical trial NCT02530931: Evaluation of Inner Ear and Brain Structures With Contrast-enhanced MRI in Patients With Meniere's Disease
Official title: Evaluation of Inner Ear and Brain Structures With Contrast-enhanced MRI in Patients With Meniere's Disease
Study type: INTERVENTIONAL
Overall status: TERMINATED
Phase: PHASE4
Conditions: Meniere's Disease
Lead sponsor: University Hospital, Grenoble
Sponsor class: OTHER
Collaborators: name: Guerbet
First posted: 2015-08-21
Enrollment: 23
Sex: ALL
Minimum age (years): 40
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: DIAGNOSTIC

Brief summary: * This prospective study aims to better characterize inner ear's perilymphatic structures with Magnetic Resonance Imaging using contrast media and delayed injection in patient's with Meniere's disease.
* MR Perfusion Imaging will be assess in both cochlea as well
* Primary auditory brain pathways will be evaluated through MR diffusion imaging


Eligibility criteria: Inclusion Criteria:

* Major subjects of over 40 years (mean age of Meniere's disease 40 to 50 years)
* Informed consent signed
* Medical examination performed prior to participation in research
* Patients with clinical criteria of Meniere's disease according to the classification of the American Association of Otology (ie the combination of a sensorineural hearing loss at low frequencies, recurrent vertigo and tinnitus and / or clogged ear sensation)
* Recipient of a French social security scheme

Exclusion Criteria:

* Patients minors
* Patients on a legal protection regime type guardianship
* Respiratory pathologies, cardiovascular, renal, diabetes
* Claustrophobia
* Contraindications to exposure to a magnetic field
* Contraindications to injecting Dotarem ®

Primary outcomes:
measure: Gadolinium enhancement in inner ear structures as measured by MR T1 Weighted-Imaging dynamic measurement
timeFrame: One MR scan (4 hours)
Secondary outcomes:
Other outcomes:
Locations:
city: Grenoble
country: France
facility: GrenobleUniversityHospital
Study officials:
affiliation: University Hospital, Grenoble
name: Arnaud ATTYE, PH
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT00921531: Adjuvant Therapy With Thalidomide for Chemoembolization in Advanced Hepatocellular Carcinoma
Official title: Phase Ⅲ Study of Adjuvant Therapy With Thalidomide for Chemoembolization in Advanced Hepatocellular Carcinoma
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: PHASE3
Conditions: Hepatocellular Carcinoma
Keywords: Hepatocellular carcinoma
thalidomide
TACE
Child-Pugh Class A or B
Lead sponsor: Fudan University
Sponsor class: OTHER
First posted: 2009-06-16
Enrollment: 200
Sex: ALL
Minimum age (years): 18
Maximum age (years): 80
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: Chemoembolization (TACE) is used in the majority of advanced hepatocellular carcinomas. Randomized clinical trials indicated that TACE improves overall survival in patients with good liver function (Child-pugh A or B). However, the shortcoming of TACE is obvious: hypoxia induced neoangiogenesis after blockage of blood supply of the tumor; repeat TACE deteriorates liver cirrhosis due to toxicity of chemotherapeutic agent to the parenchyma liver. Thalidomide has been reported to have antiangiogenic and antimetastatic effects. The objectives of adjuvant therapy with thalidomide for chemoembolization is to evaluate overall survival and time to progression.


Eligibility criteria: Inclusion Criteria:

* Hepatocellular carcinoma confirmed with pathology or identified with radiological images with typical features
* Age ≥ 18 years and ≤ 80 years
* At least one tumor nodule with one uni-dimension of ≥ 2 cm
* Child-Pugh Class A or B
* Total bilirubin ≤ 1.5 x upper limit of normal
* ALT and AST ≤ 2.0 x the upper limit of normal
* PT-INR\<2.3,PTT \< 1.5 x upper limit of normal
* Serum creatinine ≤ 1.5x upper limit of normal
* Peripheral white blood cell count of or more than 3×10(9)/L
* Peripheral platelet of or more than 50×10(9)/L
* Expected survival time not less than 3 months
* ECOG score 0-2

Exclusion Criteria:

* Tumor thrombi in main branch of portal vein
* Tumor involvement more than 70% of whole liver
* With extrahepatic metastasis
* Prior systemic chemotherapy or chemoembolization
* Congestive heart failure \> NYHA class 2
* History of HIV infection
* Active clinically serious infections (\> 2 NCI-CTC Version 3.0)
* Recurrence of HCC after liver transplantation
* Pregnant or breast-feeding
* Substance abuse, medical, psychological or social conditions that may interfere with the patient's participation in this study
* Known or suspected allergy to any agent given in association with this trial
* Patients unable to swallow oral medication
* Inclined to thrombosis
* Inclined to hemorrhage or active hemorrhage with 1 month

Primary outcomes:
measure: Overall survival
timeFrame: 36 months
Secondary outcomes:
measure: time to progression
timeFrame: 36 months
Other outcomes:
Locations:
city: Shanghai
country: China
facility: Liver Cancer Institute
state: Shanghai
Study officials:
References:
Clinical trial NCT00703131: Surgisis Anal Fistula Plug Study: An Experience in Saudi Arabia
Official title: A Single-center Single Arm Prospective Study Evaluating the Surgisis Biodesign Anal Fistula Plug
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Anal Fistula
Keywords: fistula
anal fistula
Lead sponsor: Cook Group Incorporated
Sponsor class: INDUSTRY
First posted: 2008-06-23
Enrollment: 35
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Residents of Saudi Arabia with chronic anal fistula

Brief summary: The Surgisis Anal Fistula Plug study is a clinical trial conducted in Saudi Arabia to study the safety and effectiveness of the Surgisis AFP Plug in the treatment of chronic anal fistulas.

Detailed description: Up to 30 patients will be treated with the Surgisis Anal Fistula Plug using a standardized surgical procedure to plug their anal fistula. Patients will be followed periodically until their 12-month follow-up.

Eligibility criteria: Inclusion Criteria:

* 18 years old or older
* Primary, persistent, or recurrent fistula tract that is either transsphincteric, suprasphincteric, or extrasphincteric
* Signed informed consent
* Willing to return for follow-up visits

Exclusion Criteria:

* Crohn's Disease
* Ulcerative Colitis
* HIV Positive
* Immune System Disorder
* Collagen Disorder
* Tuberculosis
* History of radiation to anorectal region
* Allergies to pig tissue
* Religious or cultural objection to use of pig tissue in this surgical application
* J-pouch fistulas
* Previous Surgisis AFP Plug placement in target fistula tract
* Tracts with acute abscess, infection or inflammation
* Superficial fistula tracts conventionally treated with fistulotomy/fistulectomy

Primary outcomes:
measure: Healing Success
timeFrame: 12 months
Secondary outcomes:
measure: Change in Quality of Life Measures
timeFrame: 3, 6, and 12 months
Other outcomes:
Locations:
city: Riyadh
country: Saudi Arabia
facility: King Khalid University Hospital
Study officials:
affiliation: King Khalid University Hospital
name: Ahmad Zubaidi, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT04924231: Effect of 1.8-mm Steep-axis Clear Corneal Incision on the Posterior Corneal Astigmatism in Candidates for Toric IOL Implantation
Official title: Effect of 1.8-mm Steep-axis Clear Corneal Incision on the Posterior Corneal Astigmatism in Candidates for Toric IOL Implantation
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Cataract
Lead sponsor: Second Affiliated Hospital, School of Medicine, Zhejiang University
Sponsor class: OTHER
First posted: 2021-06-11
Enrollment: 60
Sex: ALL
Minimum age (years): 40
Maximum age (years): 80
Standard ages: ADULT
OLDER_ADULT
Observational model: CASE_ONLY
Time perspective: RETROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: Patients, who underwent cataract surgery with a 1.8-mm steep-axis CCI at the Eye Center, the Second Affiliated Hospital of Zhejiang University

Brief summary: we aimed to analyze the effects of cataract surgery using a 1.8-mm steep-axis clear corneal incision (CCI) on the posterior corneal surfaces based on the keratometry from the rotating Scheimpflug imaging device (Pentacam HR) in candidates for toric intraocular lens (IOL) implantation

Detailed description: Preoperative and at least 1-month postoperative data measured by Pentacam HR were collected in patients for toric IOL implantation. Surgically induced astigmatism on the posterior cornea (P-SIA) was calculated based on the preoperative and postoperative keratometric data, and the related factors of P-SIA were analyzed.

Eligibility criteria: Inclusion Criteria:

1. patients aged at least 45 years old who were scheduled for cataract surgery; (2) regular corneal astigmatism ≥ 1.0 D; (3) the imaging quality parameter (QS) of Pentacam HR was "OK"; and (4) follow-up time ≥1.0 month.

Exclusion Criteria:(1) irregular corneal astigmatism; (2) corneal scar, corneal degeneration, pterygium invading the optic zone; (3) corneal endothelium count\<1,000/mm2, corneal endothelial dystrophy, iritis, glaucoma and retinal disease; (4) history of eye surgery, such as corneal refractive surgery, corneal transplantation and retinal surgery; (5) the main incision was expanded or sutures were used during surgery; and (6) some postoperative complications, such as persistent corneal edema, Descemet's membrane detachment and poor wound healing, and any others that might affect the measurement results of the Pentacam HR during the follow-up period.

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Primary outcomes:
measure: corneal astigmatism
timeFrame: post 1 month
Secondary outcomes:
Other outcomes:
Locations:
city: Hangzhou
country: China
facility: Second Affiliated Hospital, Zhejiang University School of Medicine
Study officials:
References:
Clinical trial NCT05957731: Effect of Agonist Contract Relax Versus Antagonist Contract Relax in Chronic Stroke Patient.
Official title: Effect of Agonist Contract Relax Versus Antagonist Contract Relax Technique on Spasticity and Ankle Range of Motion in Chronic Stroke Patient.
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Stroke
Keywords: Stroke
Agonist contract relax
antagonist contract relax
stretching
modified A
Lead sponsor: University of Lahore
Sponsor class: OTHER
First posted: 2023-07-24
Enrollment: 112
Sex: ALL
Minimum age (years): 40
Maximum age (years): 60
Standard ages: ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: It will be a randomized control trial with 112 patients which will be divided into two groups of 56 patients in each group. Participants will recruit through convenient sampling techniques.

Outcome measures are range of motion and spasticity. The protocol was implemented three days per week for eight consecutive weeks. Data will be collected at baseline and 8 th week after intervention.

Detailed description: Objective of the study is to compare the effects of the agonist contract-relax technique versus the antagonist contract-relax technique on spasticity and range of motion in individuals with chronic stroke.

Null hypothesis (H0):

There are no comparative effects of agonist contact-relax technique and the antagonist contract-relax technique on spasticity and ankle range of motion in chronic patients.

The alternate hypothesis (HA):

There are comparative effects of agonist contract-relax technique and the antagonist contract-relax technique on spasticity and ankle range of motion in chronic stroke patients.

The sample size came out to 94 (47 in each group) after adding 20% dropout the sample size was 47+9=56 in each group.

Eligibility criteria: Inclusion Criteria:

* Patients with a confirmed diagnosis of stroke by a neurologist.
* Inclusion of patients with both ischemic and hemorrhagic stroke.
* Both male and female patients are eligible.
* Age range between 40 to 60 years.
* Modified Ashworth Scale ranging from 0 to 2.
* Minimum muscle strength grade of 3

Exclusion Criteria:

* History of surgery on lower limb
* Who received injection therapies for reducing spasticity
* Lower extremity contracture
* Modified Ashworth scale of 3-4

Primary outcomes:
measure: Modified Ashworth Scale.
timeFrame: it will measure change in spasticity at baseline and at 8th week
measure: universal goniometer
timeFrame: it will measure change in range of motion at baseline and at 8th week
Secondary outcomes:
Other outcomes:
Locations:
city: Lahore
country: Pakistan
facility: sir Ganga Raam hospital lahore
city: Lahore
country: Pakistan
facility: univerity of Lahore teaching hopital
Study officials:
References:
Clinical trial NCT03359031: Effects of Perioperative Patient Education Regarding Compartment Syndrome on Post-operative Opioid Consumption
Official title: Effects of Perioperative Patient Education Regarding Compartment Syndrome on Post-operative Opioid Consumption
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Compartment Syndrome of Leg
Lead sponsor: Rothman Institute Orthopaedics
Sponsor class: OTHER
First posted: 2017-12-02
Enrollment: 134
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: SUPPORTIVE_CARE

Brief summary: This study is a prospective, randomized trial. Our study aims to study the effects of perioperative patient education about compartment syndrome on patients' perception of their own pain, amount of opioid medication utilization, and rate of diagnosis of compartment syndrome.


Eligibility criteria: Inclusion Criteria:

Patients with lower extremity trauma at risk for developing compartment syndrome specifically tibial plateau fractures, tibial/fibular shaft fractures, pilon fractures, and crush injuries.

Exclusion Criteria:

Patients with an extensive history of narcotic medication or drug use, polytrauma patients, and non-primary English speaking patients

Primary outcomes:
measure: narcotic consumption
timeFrame: total opioid consumption from surgery through 30 days post-op
Secondary outcomes:
Other outcomes:
Locations:
city: Philadelphia
country: United States
facility: Rothman Institute
state: Pennsylvania
Study officials:
References:
Clinical trial NCT02048631: Analysis Of Sensory Recovery Of Donor Size And Quality Life In Oral Cancer Patients
Official title: Retrospective Analysis Of Sensory Recovery Of Donor Size And Related Quality Life In Oral Cancer Patients Receiving Free Flap Reconstruction
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Oral Cancer
Keywords: oral cancer,Quality of life,Sensory
Lead sponsor: Kaohsiung Medical University Chung-Ho Memorial Hospital
Sponsor class: OTHER
First posted: 2014-01-29
Enrollment: 200
Sex: ALL
Minimum age (years): 20
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: COHORT
Time perspective: RETROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: Oral Cancer Patients Receiving Free Flap Reconstruction

Brief summary: The aim of the study is to investigate post-surgery sensory impairment and life quality changes in oral cancer patients who underwent free flap (Free Flap) on post-operative 6 months, 12 months, and 24 months, respectively


Eligibility criteria: Inclusion Criteria:

1. patients with American Society of Anesthesiologists physical status I-III
2. Older than 20 patients
3. Diagnosis of oral canaer ,requiring free flap reconstruction

Exclusion Criteria:

1. Diagnosis of a serious mental illness involving formal thought disorder (e.g., schizophrenia) documented in medical record
2. Cognitive with dementia, delirium

Primary outcomes:
measure: sensory impairment on Donor site
timeFrame: up to 2 years
Secondary outcomes:
measure: postoperative life quality using EORTC QLQ C-30 questionnaire .
timeFrame: postoperative 6 months to one year, postoperative 1 to 2 years, and over postoperative 2 years
Other outcomes:
Locations:
city: Kaohsiung
country: Taiwan
facility: Kaohsiung Medical University Chung-Ho Memorial Hospital
Study officials:
affiliation: Department of Plastic Surgery,Kaohsiung Medical University,Taiwan
name: Kao Pin Chang, MD,PhD.
role: STUDY_DIRECTOR
References:
Clinical trial NCT02090231: The Effect of Repetitive Transcranial Magnetic Stimulation for Poststroke Dysphagia Recovery
Official title: Phase 2 Study of rTMS on Poststroke Dysphagia
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: PHASE2
Conditions: Stroke
Dysphagia
Keywords: stroke
dysphagia
rTMS
Lead sponsor: Taipei Veterans General Hospital, Taiwan
Sponsor class: OTHER_GOV
First posted: 2014-03-18
Enrollment: 50
Sex: ALL
Minimum age (years): 30
Maximum age (years): 70
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: Dysphagia is one of severe complications among stroke survivors. Dysphagia is usually associated with high levels of morbidity, mortality, and financial cost. In recent years, repetitive transcranial magnetic stimulation (rTMS) has shown promise to facilitate poststroke dysphagia. However, most researches were preliminary studies in the past. The present study aims to investigate the immediate and long-term efficacy of high frequency rTMS on chronic dysphagic patients.

Detailed description: rTMS protocol: 5 Hz real or sham stimulation, 10 minutes per day, for 10 week-days.

Eligibility criteria: Inclusion Criteria:

* Poststroke dysphagia more than 3 months

Exclusion Criteria:

* Hx of seizure or a metalic device in brain or chest

Primary outcomes:
measure: Dysphagia severity on Aus TOMs swallowing score
timeFrame: up to 3 months
Secondary outcomes:
measure: Imaging evidence with video-esophagography
timeFrame: up to 3 months
Other outcomes:
Locations:
city: Taipei
country: Taiwan
facility: Taipei Veteran General Hospital
Study officials:
affiliation: No. 201, Shih- Pai Rd, Sec. 2, Taipei, 11217 Taiwan.
name: Tsui-Fen Yang, MD
role: PRINCIPAL_INVESTIGATOR
References: