louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT03276117: Wide Use of Paperless Partograph in Evaluation of Labour
Official title: Wide Using of Paperless Partograph in Evaluation of Labour
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Labor Complication
Labor Pain
Keywords: pregnancy.obstructed labour
Lead sponsor: Assiut University
Sponsor class: OTHER
First posted: 2017-09-08
Enrollment: 200
Sex: FEMALE
Minimum age (years): 25
Maximum age (years): 35
Standard ages: ADULT
Accepts healthy volunteers: yes
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: the collected data wail be analyzed using the statistical package for social science (version 10.0 for windows,SPSS.

Brief summary: Paperless partograph wide using in labour room as simple tool in evaluation of labour

Detailed description: Both world health organization ( WHO) PARTOGRAPH and modified world heath organization (WHO)PARTOGRAPH are too long labour tools in evaluation of labour so we need simple tool in evaluation of labour

Eligibility criteria: Inclusion Criteria:

* Spontaneous labour
* cephalic presentation
* pregnant 37 weeks up to full term

Exclusion Criteria:

* mail_presentation
* induced labour

Primary outcomes:
measure: Progress of labour
timeFrame: up to 2 month
Secondary outcomes:
measure: New born
timeFrame: up to 1 month
Other outcomes:
Locations:
city: Assiut
country: Egypt
facility: Faculity of Medicine ,in Assiut,Egypt
city: Assiut
country: Egypt
facility: Faculity of Medicine Assiut University
city: Assiut
country: Egypt
facility: Faculity of Medicine in Assiut,Egypt
city: Assiut
country: Egypt
facility: Faculity of Medicine,in Assiut ,Egypt
city: Assiut
country: Egypt
facility: Faculity of Medicine,in Assiut,Egypt
city: Assiut
country: Egypt
facility: Faculity of Medicine
Study officials:
affiliation: assiut universty faculity of medicine
name: mohamed khalaph, professor
role: STUDY_CHAIR
affiliation: assiut university faclity of meficibe
name: ahmad abass, professor
role: PRINCIPAL_INVESTIGATOR
References:
citation: Jadad AR, McQuay HJ. Searching the literature. Be systematic in your searching. BMJ. 1993 Jul 3;307(6895):66. doi: 10.1136/bmj.307.6895.66-a. No abstract available.
citation: Chang AA, Heskett KM, Davidson TM. Searching the literature using medical subject headings versus text word with PubMed. Laryngoscope. 2006 Feb;116(2):336-40. doi: 10.1097/01.mlg.0000195371.72887.a2.
citation: Fatehi F, Gray LC, Wootton R. How to improve your PubMed/MEDLINE searches: 3. advanced searching, MeSH and My NCBI. J Telemed Telecare. 2014 Mar;20(2):102-12. doi: 10.1177/1357633X13519036.
Clinical trial NCT01619917: The Role of Fractional Vascular Laser Therapy in the Management of Burn Scars
Official title: The Role of Fractional Vascular Laser Therapy in the Management of Burn Scars
Study type: INTERVENTIONAL
Overall status: RECRUITING
Phase: NA
Conditions: Burn Scar
Keywords: burn
scar
laser
fractional
vascular
Lead sponsor: University of Manitoba
Sponsor class: OTHER
First posted: 2012-06-14
Enrollment: 6
Sex: ALL
Minimum age (years): 18
Maximum age (years): 60
Standard ages: ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: SINGLE_GROUP
Primary purpose: TREATMENT

Brief summary: While the literature tends to support the use of laser therapy in the management of burn scars, there is a definite lack of appropriately powered, randomized controlled trials. Laser therapy can be quite expensive when compared to other treatment modalities for burn scars, and while promising, its true usefulness has yet to be conclusively demonstrated. For this reason, our assessing the effects of fractional vascular lasers on burn scars. It has been hypothesized that the fractional vascular lasers work on mature scars to decrease scar formation, and the fractional laser works on scar that is quiescent to promote remodelling. The retexturing/ resurfacing of the laser theoretically can decrease the visibility of the mesh pattern created by meshed split thickness skin graft).

Objective:

To determine the benefit of fractional vascular laser treatment in improving burn scar height, texture, vascularity and pliability in late burn scars.


Eligibility criteria: Inclusion Criteria:

* living in Winnipeg
* burn scar 6-12 months old
* Fitzpatrick skin type I-III
* thermal burn scar on trunk or extremities

Exclusion Criteria:

* open wound

Primary outcomes:
measure: reduction in scar appearance
timeFrame: every 3 weeks to 15 weeks
Secondary outcomes:
Other outcomes:
Locations:
city: Winnipeg
country: Canada
facility: University of Manitoba
state: Manitoba
Study officials:
affiliation: University of Manitoba
name: S Logsetty, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT05421117: Comparison of Laparoscopic Adnexal Mass Extraction Via the Transumbilical and Transvaginal Routes
Official title: Comparison of Laparoscopic Adnexal Mass Extraction Via the Transumbilical and Transvaginal Routes
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Surgical Procedure, Unspecified
Lead sponsor: Erzincan Military Hospital
Sponsor class: OTHER
First posted: 2022-06-16
Enrollment: 93
Sex: FEMALE
Minimum age (years): 16
Maximum age (years): 80
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: CASE_CONTROL
Time perspective: RETROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Women who underwent laparoscopic surgery for the removal of benign adnexal masses at three centers between January 2016 and December 2020 were examined retrospectively.

Brief summary: Adnexal masses are a common clinical problem encountered in gynecological practice. Minimally invasive surgery (MIS) for ovarian pathologies has been adopted widely. Its goals are to minimize abdominal incisions and postoperative pain and to prevent incisional complications, such as incisional hernias and adhesions. Compared with open procedures, MIS is associated with faster recovery times, better patient quality of life, and lower postoperative complication rates. The removal of an adnexal mass from the abdominal cavity is performed most commonly using the suprapubic, umbilical, or vaginal route. Apart from these, mini laparoscopy can provide a better cosmetic result without additional operative time or complications. Despite the limited use of mini laparoscopy for gynecological procedures, its use has increased recently.

After excision, an adnexal mass can be removed through a laparoscopic (LS) port using a variety of endoscopic or containment bags. After the mass has been placed in it, the bag is withdrawn, closed, and expelled through the skin incision with simultaneous trocar removal. When a mass is large or cannot be removed through the port, the incision may be enlarged slightly. This situation may yield a cosmetically worse outcome and increases the risk of postoperative complications, such as adhesion, hernia, and increased postoperative pain. Thus, natural orifice surgery (NOS) has emerged for tissue removal in such cases.

This study was performed to compare the transumbilical (TU) and transvaginal (TV) routes for adnexal mass removal from the abdominal cavity


Eligibility criteria: Inclusion Criteria:

-Women who underwent laparoscopic surgery for the removal of benign adnexal masses

Exclusion Criteria:

-Patients with missing data about surgery information

Primary outcomes:
measure: Incisional pain score
timeFrame: The time between the end of the surgery and 3 hours after the operation
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
References:
Clinical trial NCT03203317: Myocellular Signalling in Skeletal Muscle
Official title: Insulin-dependent and Exercise-induced Myocellular Signalling in Skeletal Muscle
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Exercise
Insulin Sensitivity
Lead sponsor: University of Copenhagen
Sponsor class: OTHER
First posted: 2017-06-29
Enrollment: 8
Sex: MALE
Minimum age (years): 18
Maximum age (years): 35
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: CROSSOVER
Primary purpose: BASIC_SCIENCE

Brief summary: The study will investigate myocellular signalling in skeletal muscle after insulin-stimulation and exercise in healthy young men


Eligibility criteria: Inclusion Criteria:

* healthy
* informed consent
* habitual training (2-5 h/week)
* VO2max of 40-60 ml/min/kg
* lean mass 55-65 kg

Exclusion Criteria:

* smoker
* allergy towards insulin
* chronic disease

Primary outcomes:
measure: Change in muscle phospho-proteome signature
timeFrame: Before and after 10 minutes of exercise, as well as before and after a 2 hour insulin stimulation
Secondary outcomes:
Other outcomes:
Locations:
city: Copenahgen
country: Denmark
facility: August Krogh Building
Study officials:
References:
Clinical trial NCT05941117: Effect of Exercises on Dynamic Balance in Knee Osteoarthritis Patients.
Official title: Effect of Weight Bearing Versus Non-weight Bearing Strengthening Exercises on Dynamic Balance in Knee Osteoarthritis Patients.
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Knee Osteoarthritis
Lead sponsor: Cairo University
Sponsor class: OTHER
First posted: 2023-07-12
Enrollment: 60
Sex: ALL
Minimum age (years): 50
Maximum age (years): 70
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: This study is a randomized controlled trial which aims to compare the effect of weight bearing exercises and non-weight bearing exercises on the dynamic balance in knee osteoarthritis patients as 60 patients will divided in three groups where one group is control group and others two groups one of them perform weight bearing exercises and the other perform non weight bearing exercises.


Eligibility criteria: Inclusion Criteria:

* The patient's age \> 50 years.
* Recent radiographs confirming the presence of knee OA, grade II-III (mild to moderate) Kellgren Lawrence (K/L).
* Body mass index (BMI) from 20 to 30 kg/m2.
* Met the American College of Rheumatology clinical criteria for mild to moderate knee OA.
* knee pain \> 3 cm on a 10 cm visual analog scale (VAS) on most days of the previous week.
* Bilateral knee osteoarthritis.

Exclusion Criteria:

* Congenital or acquired inflammatory or neurological (systemic or local) diseases involving the knee.
* Patients who have mental or cognitive illness that interfere their ability to perform the exercises or the evaluation tests.
* Intra articular knee injection of steroids in the past 6 months.
* Patients who had received joint replacement surgery in either Knee or hip.
* Patients with rheumatoid arthritis.
* Patients who received physical therapy sessions on the knee in the past 6 months.

Primary outcomes:
measure: change happened in the dynamic balance from the baseline
timeFrame: one day after the end of treatment
Secondary outcomes:
measure: change happened in pain from the baseline
timeFrame: one day after the end of treatment
measure: change happened in the joint angle repositioning from baseline
timeFrame: one day after the end of treatment
Other outcomes:
Locations:
city: Giza
country: Egypt
facility: Faculty of physical therapy Cairo University
Study officials:
References:
Clinical trial NCT06002217: Echo-guided Transverse Abdominal Plane Block (TAP) in Anterior Lumbar Arthrodesis (ALIF)
Official title: Echo-guided Transverse Abdominal Plane Block (TAP) in Anterior Lumbar Arthrodesis (ALIF): Randomized, Double-blind, Controlled Trial.
Study type: INTERVENTIONAL
Overall status: RECRUITING
Phase: NA
Conditions: Fusion of Spine, Lumbar Region
Lead sponsor: Clinique Saint Jean, France
Sponsor class: OTHER
First posted: 2023-08-21
Enrollment: 80
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The goal of this interventional study is to is to compare the effect of a tap block versus a placebo in patients undergoing anterior lumbar spine surgery.

The main question it aims to answer :

• whether tap block can reduce the need for postoperative pain medication Participants will be randomized into two groups and all postoperative pain medication will be recorded over 3 days.

Researchers will compare tap block vs placebo to see if it reduces postoperative pain.


Eligibility criteria: Inclusion Criteria:

Patient affiliated or entitled to a social security plan.

* Patient who has been informed about the study and has co-signed a consent form with the investigator. consent to participate in the study.
* Patients over 18 years of age scheduled for abdominal disc surgery on one or two levels.
* Patient with ASA criteria 1, 2 and 3.

Exclusion Criteria:

* Patients with intolerance or contraindication to paracetamol, anti-inflammatory or morphine.
* Patients allergic to local anesthetics.
* Pregnant or breast-feeding patient.
* patient undergoing cancer or trauma surgery trauma.
* Patient participating in another interventional study.
* Patient with a history of lumbar arthrodesis.
* Patient refusing to sign consent form.
* Patient unable to give informed consent.
* Patient under court protection, guardianship or trusteeship.
* Patient not available for study follow-up.

Primary outcomes:
measure: Analgesic consumption
timeFrame: 72hours
Secondary outcomes:
measure: Pain assessment will be reported for 72 hours after surgery measured on a Visual analogue scale between 0 and 10
timeFrame: 72hours
Other outcomes:
Locations:
city: Montpellier
country: France
facility: Clinique St jean sud de france
Study officials:
References:
Clinical trial NCT03437317: Emotional Perceptual Training as a Treatment for Social Anxiety: Behavioral and Neural Evidence.
Official title: Emotional Perceptual Training as a Treatment for Social Anxiety: Behavioral and Neural Evidence.
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Anxiety Disorders and Symptoms
Social Anxiety Disorder
Keywords: Social Anxiety
Threat processing
Magnetoencephalography (MEG)
Lead sponsor: Florida State University
Sponsor class: OTHER
Collaborators: name: Medical College of Wisconsin
First posted: 2018-02-19
Enrollment: 154
Sex: ALL
Minimum age (years): 18
Maximum age (years): 35
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Intervention model description: Participants were randomly assigned to either an active training group or a control group. The active participants completed 8 blocks of a perceptual training task, while the control group performed 8 blocks of a gender discrimination task

that received the perceptual retraining protocol
Primary purpose: TREATMENT

Brief summary: The Perceptual Training Study is a series of studies performed with the purpose of identifying a potential avenue for treatment of mood disorders, particularly anxiety-based mood disorders. The underlying theme is that neural representations may be threat-oriented, and may also be generalized to non-threatening cues by means of similarity to threatening representations. These may result in anxiety symptoms from innocuous cues. The idea behind the perceptual training is to create a divorce between the threat representations and cues which should be considered non-threatening, enhancing perceptual acuity and potentially reducing anxiety symptoms.


Eligibility criteria: Inclusion Criteria:

* Right-handed
* Normal or corrected-to-normal vision

Exclusion Criteria:

* History of a diagnosed neurological or Diagnostic and Statistical Manual of Mental Disorders - IV Axis I disorder
* Currently taking prescribed psychoactive drugs, including anti-depressants or anxiolytics.
* Having electrically, magnetically, or mechanically activated implants (e.g. cardiac pacemakers), due to incompatibility with MRI and MEG systems.
* Pregnancy or suspected pregnancy

Primary outcomes:
measure: Behavioral Evidence for Categorical Perception Changes
timeFrame: Baseline to Study Completion (14 to 28 Days)
measure: Neural Evidence for Categorical Perception Changes
timeFrame: Baseline to Study Completion (14 to 28 Days)
Secondary outcomes:
measure: Social Anxiety Symptoms - Social Phobia Scale
timeFrame: Baseline to Study Completion (14 to 28 Days)
measure: Social Anxiety Symptoms - Liebowitz Social Anxiety Scale
timeFrame: Baseline to Study Completion (14 to 28 Days)
Other outcomes:
Locations:
Study officials:
References:
Clinical trial NCT04210817: A Pilot Study to Explore the Role of Gut Flora in Rheumatoid Arthritis
Official title: A Non-Interventional Pilot Study to Explore the Role of Gut Flora in Rheumatoid Arthritis
Study type: OBSERVATIONAL
Overall status: WITHDRAWN
Conditions: Rheumatoid Arthritis
Arthritis, Rheumatoid
Arthritis
Lead sponsor: ProgenaBiome
Sponsor class: OTHER
First posted: 2019-12-26
Enrollment: 0
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: CASE_ONLY
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Patients with Rheumatoid Arthritis

Brief summary: This study seeks to correlate microbiome sequencing data with information provided by patients and their medical records regarding Rheumatoid Arthritis

Detailed description: The goal of this Research Study is to better understand how the genetic information in subject's microbiome correlates to the information provided in surveys and in medical records regarding Rheumatoid Arthritis.

Eligibility criteria: Inclusion Criteria:

1. Signed informed consent, demonstrating that the patient understands the procedures required for the study and the purpose of the study
2. Male or female patients of any age (interest is given to children to compare with mothers).
3. Diagnosis of Rheumatoid Arthritis

Exclusion Criteria:

1. Refusal to sign informed consent form
2. History of bariatric surgery, total colectomy with ileorectal anastomosis or proctocolectomy.
3. Postoperative stoma, ostomy, or ileoanal pouch
4. Participation in any experimental drug protocol within the past 12 weeks
5. Treatment with total parenteral nutrition
6. Any clinically significant evidence of disease that could interfere with the subject's ability to enter the trial
7. Inability to adequately communicate with the investigator or their respective designee and/or comply with the requirements of the entire study

Primary outcomes:
measure: Correlation of Microbiome to Disease via Relative Abundance and Presence of Absence of Specific Bacterial Species Found in Microbiome Sequencing
timeFrame: One year
Secondary outcomes:
Other outcomes:
Locations:
city: Ventura
country: United States
facility: ProgenaBiome
state: California
Study officials:
affiliation: ProgenaBiome
name: Sabine Hazan, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT06918717: Prehospital Tracheal Intubation Technique Using Initial Direct Laryngoscopy During Videolaryngoscopy
Official title: Assessment of Prehospital Tracheal Intubation Technique Using Initial Direct Laryngoscopy During Videolaryngoscopy: Randomized Controlled Simulated Trial
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Tracheal Intubation
Keywords: Advanced airway management
direct laryngoscopy
tracheal intubation
prehospital
videolaryngoscopy
Lead sponsor: University Hospital, Geneva
Sponsor class: OTHER
First posted: 2025-04-09
Enrollment: 72
Sex: ALL
Minimum age (years): 18
Maximum age (years): 50
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: OTHER

Brief summary: Tracheal intubation using videolaryngoscopy may be required in the prehospital setting, where airway management presents unique technical and logistical challenges. Intubation may be hard because novice providers performing videolaryngoscopy may only look at the screen and only obtain a two-dimensional representation of the patient's airways. By directly visualizing the airways, these providers may obtain a better 3D apprehension and an improved mental visualization of the patient's anatomy. We aim to compare the impact of a freely realized videolaryngoscopy sequence with a sequence consisting in direct visualization of the airway followed by videolaryngoscopy ("Direct Laryngoscopy-to-VideoLaryngoscopy sequence" or "DL-VL sequence") on time to intubation among novice providers.


Eligibility criteria: Inclusion Criteria:

* All resident physicians with 1 to 6 years of post-graduate experience working in the Emergency Department (ED) at Geneva University Hospitals (Hôpitaux Universitaires de Genève (HUG)) and penultimate year of medical school students (5th year) studying at University of Geneva Faculty of Medicine (UGFM).
* Performed less than 10 ETIs prior to participating in the study.

Exclusion Criteria:

* More than 6 years of post-graduate experience
* Performed more than 10 ETIs prior to participating in the study.

Primary outcomes:
measure: Time to Intubation
timeFrame: Periprocedural
Secondary outcomes:
measure: Time to Intubation for the first intubation attempt alone
timeFrame: Periprocedural
measure: First Pass Success rate
timeFrame: Periprocedural
measure: Number of intubations attempts
timeFrame: Periprocedural
measure: Time to Ventilation
timeFrame: Periprocedural
measure: Subjective assessments
timeFrame: Periprocedural
Other outcomes:
Locations:
city: Geneva
country: Switzerland
facility: Hôpitaux Universitaires de Genève
Study officials:
affiliation: University Hospital, Geneva
name: PD Dr Laurent Suppan
role: STUDY_DIRECTOR
References: