Clinical trial NCT06617559: Comparison of Autologous Quadriceps and Hamstring Tendon Grafts in Anterior Cruciate Ligament Reconstruction
Official title: A Prospective Comparison of Clinical and Radiological Maturation Outcomes of Autologous Quadriceps and Hamstring Tendon Grafts in Anterior Cruciate Ligament Reconstruction
Study type: INTERVENTIONAL
Overall status: RECRUITING
Phase: NA
Conditions: Anterior Cruciate Ligament Injuries
Athletic Injuries
Tendon Graft; Complications
Keywords: anterior cruciate ligament reconstruction
hamstring tendons
athletic injuries
Lead sponsor: Acibadem University
Sponsor class: OTHER
Collaborators: name: Acibadem University
First posted: 2024-09-27
Enrollment: 25
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Intervention model description: There are two standard autografts used for ACL reconstruction in the investigators\&#39; clinic: quadriceps and hamstring autografts. Patients will be randomly assigned to groups based on the order of their hospital admission. It is planned to have at least 25 patients in each group.
Primary purpose: TREATMENT

Brief summary: With the recent technological advancements, the use of the quadriceps tendon with an all-inside technique has come to the forefront, and large-scale research has focused especially on quadriceps tendon grafts. Clinical study results have reported that the outcomes are similar to those of patellar tendon grafts and either equivalent or superior to hamstring tendon grafts.

The aim of this study is the prospective comparison of the clinical and radiological outcomes of patients who underwent anterior cruciate ligament (ACL) reconstruction with autologous hamstring and quadriceps tendon grafts.


Eligibility criteria: Inclusion Criteria:

* Elite athletes
* Amateur athletes
* Anterior cruciate ligament injury

Exclusion Criteria:

* Revision surgery
* Another ligament injury ( medial collateral ligament, lateral collateral ligament, etc.. )
* \> Grade-2 cartilage injury
* Having previously undergone surgery on the same knee
* \< 18 years age

Primary outcomes:
measure: Autograft Maturation
timeFrame: 12 months
measure: Stability of Knee
timeFrame: 9 months
measure: Stability of Knee
timeFrame: 9 months
measure: Stability of Knee
timeFrame: 9 months
Secondary outcomes:
measure: Range of Motion
timeFrame: 6 months
measure: Muscle Strength
timeFrame: 9 months
Other outcomes:
Locations:
city: Istanbul
country: Turkey
facility: Acibadem Fulya Hospital
Study officials:
References:
citation: Mouarbes D, Menetrey J, Marot V, Courtot L, Berard E, Cavaignac E. Anterior Cruciate Ligament Reconstruction: A Systematic Review and Meta-analysis of Outcomes for Quadriceps Tendon Autograft Versus Bone-Patellar Tendon-Bone and Hamstring-Tendon Autografts. Am J Sports Med. 2019 Dec;47(14):3531-3540. doi: 10.1177/0363546518825340. Epub 2019 Feb 21.
citation: Lin KM, Boyle C, Marom N, Marx RG. Graft Selection in Anterior Cruciate Ligament Reconstruction. Sports Med Arthrosc Rev. 2020 Jun;28(2):41-48. doi: 10.1097/JSA.0000000000000265.
citation: Cavaignac E, Coulin B, Tscholl P, Nik Mohd Fatmy N, Duthon V, Menetrey J. Is Quadriceps Tendon Autograft a Better Choice Than Hamstring Autograft for Anterior Cruciate Ligament Reconstruction? A Comparative Study With a Mean Follow-up of 3.6 Years. Am J Sports Med. 2017 May;45(6):1326-1332. doi: 10.1177/0363546516688665. Epub 2017 Mar 8.