Clinical trial NCT04748263: Eye Gaze Strategies During Facial Emotion Recognition in Neurodegenerative Diseases: Links With Neuropsychiatric Disorders (EYE-ToM Study)
Official title: Eye Gaze Strategies During Facial Emotion Recognition in Neurodegenerative Diseases: Links With Neuropsychiatric Disorders (EYE-ToM Study)
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Alzheimer's Dementia
Parkinson Disease(PD)
Fronto-Temporal Dementia
Keywords: Eye-Tracking
Neuropsychological evaluations
Lead sponsor: Centre Hospitalier Princesse Grace
Sponsor class: OTHER
Collaborators: name: Association de Recherche Bibliographique pour les Neurosciences
First posted: 2021-02-10
Enrollment: 70
Sex: ALL
Minimum age (years): 45
Standard ages: ADULT
OLDER_ADULT
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Patient 45 years old and above healthy or with FTD, AD or PD pathology

Brief summary: It is commonly admitted that social cognition impairment, like deficit in facial emotion recognition or misinterpretation of others' intentions (Theory of Mind), are associated with social behavior disorders.

This kind of disorders are observed in Fronto-Temporal Dementia (FTD), Alzheimer's Dementia (AD) and Parkinson's Disease (PD), with severe deficits in FTD and lighter deficits in AD and PD.

One explanation might be that patients apply inappropriate visual exploration strategies to decode emotions and intentions of others.

This study aims to test this hypothesis and further to analyse whether different patterns emerge from these pathologies.


Eligibility criteria: Inclusion Criteria:

* Hospitalized or coming to perform a consultation, for whom an Eye-Tracking examination is indicated as part of routine care.
* Sufficient written and oral expression in French.
* Written informed consent signed by the patient.
* For the control group: No cognitive impairment (non pathological MMSE (according to age, gender and socio-cultural level), no neurological history, and no psychiatric history (especially anxiety and depressive disorders).
* For the FTD group: Patient diagnosed according to revised Rascovsky et al. 2011., no neurological history (excepted diagnosed FTD), and no psychiatric history (excepted those related to diagnosed FTD).
* For the AD group: Patient diagnosed according to DSM-IV-TR criteria, no neurological history (excepted diagnosed AD), and no psychiatric history (excepted those related to diagnosed AD).
* For the PD group: Patient diagnosed according to NINDS criteria, no neurological history (excepted diagnosed PD), and no psychiatric history (excepted those related to diagnosed PD).

Exclusion Criteria:

* General anaesthesia within 3 months.
* Ophthalmological problems preventing a video-oculography examination.
* Oculomotor disorders such as "fixation disorders" or "ocular tracking disorders".
* Cognitive disorders of the type: visual agnosia, visuo-spatial disorder, visuo-perceptual disorder or aphasia.
* History of stroke.
* History of alcohol or drug abuse.

Primary outcomes:
measure: Eye gaze strategies (number of eye fixation) during Affective Theory of Mind (ToM)
timeFrame: Baseline
measure: Eye gaze strategies (duration of eye fixations) during Affective Theory of Mind (ToM)
timeFrame: Baseline
measure: Eye gaze strategies (response times) during Affective Theory of Mind (ToM)
timeFrame: Baseline
measure: Eye gaze strategies (number of eye fixation) during Facial emotion recognition (FER)
timeFrame: Baseline
measure: Eye gaze strategies (duration of eye fixation) during Facial emotion recognition (FER)
timeFrame: Baseline
measure: Eye gaze strategies (response times) during Facial emotion recognition (FER)
timeFrame: Baseline
Secondary outcomes:
measure: Facial emotion recognition (FER) performances
timeFrame: Baseline
measure: Affective ToM performances
timeFrame: Baseline
measure: Behavioral disorders.
timeFrame: Baseline
Other outcomes:
Locations:
Study officials:
affiliation: CH Princesse Grace
name: Alain PESCE, MD-PHD
role: PRINCIPAL_INVESTIGATOR
affiliation: CH Princesse Grace
name: Sandrine LOUCHART de la CHAPELLE, MD
role: PRINCIPAL_INVESTIGATOR
References: