louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT00848900: Guangzhou Outdoor Activity Longitudinal Study
Official title: A Controlled Clinical Trial of the Effect of Increases Time Outdoors in the Prevention of Juvenile-onset Myopia in Chinese Children
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Myopia
Lead sponsor: Sun Yat-sen University
Sponsor class: OTHER
First posted: 2009-02-20
Enrollment: 2000
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: SINGLE_GROUP
Primary purpose: PREVENTION

Brief summary: The purpose of this study is to assess whether outdoor activities are effective in preventing the development and progression of juvenile-onset myopia in Chinese children.

Detailed description: 1. To determine if increased engagement in outdoor activities reduces the development and progression of myopia in Chinese school children.
2. To identify the risk factors associated with the development and progression of juvenile-onset myopia.
3. To characterize the interaction between refractive error and education.

Eligibility criteria: Inclusion Criteria:

* All the students in Grade 1

Exclusion Criteria:

* No

Primary outcomes:
measure: Cycloplegic refraction
timeFrame: 1 year
Secondary outcomes:
measure: Visual acuity
timeFrame: 6 months
Other outcomes:
Locations:
city: Guangzhou
country: China
facility: Zhongshan Ophthalmic Center
state: Guangdong
Study officials:
affiliation: Zhongshan Ophthalmic Center, Sun Yat-sen University
name: Mingguang He, PhD, MD
role: PRINCIPAL_INVESTIGATOR
References:
citation: He M, Xiang F, Zeng Y, Mai J, Chen Q, Zhang J, Smith W, Rose K, Morgan IG. Effect of Time Spent Outdoors at School on the Development of Myopia Among Children in China: A Randomized Clinical Trial. JAMA. 2015 Sep 15;314(11):1142-8. doi: 10.1001/jama.2015.10803.
citation: Zhou Z, Morgan IG, Chen Q, Jin L, He M, Congdon N. Disordered sleep and myopia risk among Chinese children. PLoS One. 2015 Mar 26;10(3):e0121796. doi: 10.1371/journal.pone.0121796. eCollection 2015.
Clinical trial NCT03824600: Physiological Patterns of Coronary Artery Disease
Official title: Physiological Patterns of Coronary Artery Disease
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Coronary Artery Disease
Lead sponsor: Onze Lieve Vrouw Hospital
Sponsor class: OTHER
First posted: 2019-01-31
Enrollment: 117
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: Patients undergoing clinically indicated coronary angiography and fractional flow reserve evaluation for intermediate coronary lesions defined as visual diameter stenosis between 30% and 70%

Brief summary: Registry of patients undergoing invasive fractional flow reserve measurement using a motorized device.

Detailed description: A prospective registry of patients undergoing clinically indicated coronary angiography with fractional flow reserve evaluation for vessels with intermediate coronary lesions defined as visual diameter stenosis between 30% and 70%. A motorized fractional flow reservepullback evaluation will be performed at the discretion of the operators. The objective of the present study is to describe the physiological patterns of coronary artery disease using motorized coronary pressure pullbacks during continuous hyperemia in patients with stable coronary artery disease.

Eligibility criteria: Inclusion Criteria:

* Stable coronary artery disease

Exclusion Criteria:

* acute coronary syndromes
* previous coronary artery bypass grafting
* significant valvular disease
* severe obstructive pulmonary disease or asthma bronchial
* severe tortuosity or severe calcification

Primary outcomes:
measure: Physiological Patterns of Coronary Artery Disease (i.e. focal, diffuse or combined)
timeFrame: Immediate post-procedure. No follow-up is schedule for this trial.
Secondary outcomes:
Other outcomes:
measure: Classification of the physiological patterns of coronary artery disease using a quantitative metric
timeFrame: Immediate post-procedure. No follow-up is schedule for this trial.
Locations:
city: Aalst
country: Belgium
facility: OLV Aalst
state: West Flanders
city: Brussels
country: Belgium
facility: University of Brussels
Study officials:
affiliation: OLV-Aalst
name: Bernard De Bruyne, MD, PhD
role: STUDY_CHAIR
References:
citation: Argacha JF, Decamp J, Vandeloo B, Babin D, Lochy S, Van den Bussche K, de Hemptinne Q, Xaplanteris P, Magne J, Segers P, Cosyns B. Guiding Myocardial Revascularization by Algorithmic Interpretation of FFR Pullback Curves: A Proof of Concept Study. Front Cardiovasc Med. 2021 Mar 11;8:623841. doi: 10.3389/fcvm.2021.623841. eCollection 2021.
citation: Collet C, Sonck J, Vandeloo B, Mizukami T, Roosens B, Lochy S, Argacha JF, Schoors D, Colaiori I, Di Gioia G, Kodeboina M, Suzuki H, Van 't Veer M, Bartunek J, Barbato E, Cosyns B, De Bruyne B. Measurement of Hyperemic Pullback Pressure Gradients to Characterize Patterns of Coronary Atherosclerosis. J Am Coll Cardiol. 2019 Oct 8;74(14):1772-1784. doi: 10.1016/j.jacc.2019.07.072.
Clinical trial NCT01981200: Feasibility of Strength Training in Patients Hospitalized Due to COPD
Official title: Feasibility of Progressive Knee Extension Strength Training Using Ankle Weight Cuffs in Patients Hospitalized With COPD in Acute Exacerbation
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: COPD
Muscle Weakness
Keywords: COPD acute exacerbation
Physiotherapy
Resistance training
Muscle strength
Handheld dynamometer
Lead sponsor: Frederikssunds Hospital, Denmark
Sponsor class: OTHER
Collaborators: name: Copenhagen University Hospital, Hvidovre
First posted: 2013-11-11
Enrollment: 40
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: TREATMENT

Brief summary: To examine the feasibility of progressive unilateral knee-extension strength training using ankle weight cuffs in patients hospitalized due to acute exacerbation in COPD

Detailed description: We decided that feasibility is indicated if: 1) the absolute training loads increase progressively, 2) more than 80% of the planned training sessions are completed, and 3)if the absolute training loads do not exceed 20 kg (2 x10kg weight cuffs) for 90% of patients.

Eligibility criteria: Inclusion Criteria:

* Have a primary diagnosis of COPD
* Be admitted to the pulmonary ward due to an exacerbation in COPD
* Provide informed consent to participation in the study
* Be able to maintain an upright position on a chair
* Be able to be guided to training and understand instructions for participating

Exclusion Criteria:

Patients suffering from diseases that prevents the use of wrist weights such as

* Deep venous thrombosis (DVT)
* Erysipelas
* Painful edema of the limbs
* Lack of ability to walk, habitually
* Predicted hospital stay of less than four days as predicted by a pulmonary physician
* Patients admitted Friday night or Saturday morning cannot be stared up within 24 hours of admittance

Primary outcomes:
measure: Increase of training load during admission
timeFrame: The patients will be followed for the duration of hospital stay, an expected average of 6 days
Secondary outcomes:
measure: Maximal isometric knee extension strength
timeFrame: The patients will be followed for the duration of hospital stay, an expected average of 6 days
measure: Sit-to- stand- test
timeFrame: The patients will be followed for the duration of hospital stay, an expected average of 6 days
measure: Timed Up and Go (TUG)
timeFrame: The patients will be followed for the duration of hospital stay, an expected average of 6 days
Other outcomes:
Locations:
city: Frederikssund
country: Denmark
facility: Nordsjællands Hospital - Frederikssund
Study officials:
affiliation: Nordsjællands Hospital - Frederikssund
name: Linette M Kofod, PT
role: PRINCIPAL_INVESTIGATOR
affiliation: Copenhagen University Hospital, Hvidovre
name: Morten T Kristensen, PhD
role: STUDY_CHAIR
References:
Clinical trial NCT00817700: Impact of a Sleep Debt in Middle-Aged and Older Adults
Official title: Alteration of Sleep and Circadian Timing in Aging- Impact of a Sleep Debt in Middle-Aged and Older Adults
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Sleep Restriction
Keywords: Sleep
young adults
middle-age adults
older adults
Lead sponsor: University of Chicago
Sponsor class: OTHER
First posted: 2009-01-06
Enrollment: 72
Sex: ALL
Minimum age (years): 18
Maximum age (years): 75
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: NON_RANDOMIZED
Intervention model: SINGLE_GROUP

Brief summary: This project has 6 aims.

1. To examine the impact of recurrent partial sleep loss in young, middle-aged and older men and women. Sleep will be restricted to 4 hours.
2. To test the hypothesis that extending bedtimes to allow for sleep recovery will reverse the metabolic, endocrine, and cardiovascular and neuro-behavioral alterations resulting from sleep restriction. Sleep will be extended to 12 hours following the 4 hour sleep restriction.
3. To test the hypothesis that there are age and gender differences in the total amount of sleep recovery obtained during the week of 12-hour bedtimes.
4. To test the hypothesis that there are age and gender differences in sleep capacity (the amount of time an individual can sleep per night when there is no sleep debt).
5. To test the hypothesis that sleep capacity is partly determined by baseline levels of slow-wave sleep and slow-wave activity.
6. To determine whether sleep capacity is related to sleep need by examining metabolic, endocrine, cardiovascular and neuro-behavioral changes with the amount of the individual sleep debt.


Eligibility criteria: Inclusion Criteria:

* normal weight
* healthy
* age 18-75 old

Exclusion Criteria:

* sleep disorder
* irregular life habits (shift workers, travelers)
* smokers
* on medication
* consumption of \> 2 alcohol or caffeinated beverages/day

Primary outcomes:
measure: Endocrine, metabolic, cardiovascular changes performance and autonomic nervous system activity before and after sleep restriction and after sleep recovery.
timeFrame: Completion of 23 day study
Secondary outcomes:
Other outcomes:
Locations:
city: Chicago
country: United States
facility: The University of Chicago
state: Illinois
Study officials:
affiliation: University of Chicago
name: Eve Van Cauter, PhD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT04774900: Standardization of Ambulance Equipment
Official title: The Influence of Standardization of Ambulance Equipment on the Speed of Medical Procedures Provision
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Safety Issues
Keywords: quality and safety
emergency medical services
paramedics
equipment
standardisation
Lead sponsor: Emergency Medical Service, Prague
Sponsor class: OTHER_GOV
First posted: 2021-03-01
Enrollment: 100
Sex: ALL
Minimum age (years): 21
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Paramedics of the Prague Emergency Medical Services - bachelor or higher professional education as paramedics.

Brief summary: The aim of the research is to find out what effect the standardization of ambulance equipment has on the speed of performing specific medical procedures.

Detailed description: The aim of the research is to find out what effect the standardization of ambulance equipment has on the speed of performing specific medical procedures. In two simulated scenarios, the times from the decision to execution of medical procedures will be measured. In the first scenario, the equipment is located in the standard way and the research participants know where it is located. In the second scenario, the equipment is placed elsewhere and participants do not have the opportunity to check the equipment before the scenario. For the statistical comparison the Student's T-test and Wilcoxon signed-rank test will be used. For analysis of variance will be used the ANOVA test and for more than two dependent selections the Friedman's ANOVA test will be used.

Eligibility criteria: Inclusion Criteria:

* consent to participate
* times of all procedures recorded
* all procedures provided in a correct way - in meaning of quality of the procedure

Exclusion Criteria:

* disagreement with participation
* not all procedures provided or not provided correctly

Primary outcomes:
measure: Time
timeFrame: Through study completion, an average of 6 months and/or until 100 cases will be collected.
Secondary outcomes:
Other outcomes:
Locations:
city: Praha
country: Czechia
facility: Prague Emergency Medical Services
Study officials:
affiliation: Prague EMS
name: David Peran, Dr.
role: STUDY_CHAIR
affiliation: Prague EMS
name: Miroslav Tejkl, MS
role: STUDY_DIRECTOR
affiliation: EMS of Karlovy Vary Region
name: Roman Sýkora, Ph.D.
role: PRINCIPAL_INVESTIGATOR
affiliation: 3rd Faculty of Medicine, Charles University in Prague
name: Metodej Renza, MD
role: PRINCIPAL_INVESTIGATOR
affiliation: Prague EMS
name: Jaroslav Pekara, Ph.D.
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT02971800: Evaluation of Sodium Fluorescein Use During Intraoperative Cystoscopy After Total Laparoscopic Hysterectomy
Official title: Evaluation of Sodium Fluorescein Use During Intraoperative Cystoscopy After Total Laparoscopic Hysterectomy
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Ureteral Injury
Keywords: sodium fluorescein
ureteral efflux
laparoscopic hysterectomy
Lead sponsor: CHU de Quebec-Universite Laval
Sponsor class: OTHER
First posted: 2016-11-23
Enrollment: 37
Sex: FEMALE
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: DIAGNOSTIC

Brief summary: The primary objective is to describe the safety and efficacy of intravenous sodium fluorescein to visualize ureteral efflux during intraoperative cystoscopy after total laparoscopic hysterectomy. Secondary objective is to report on surgeon's satisfaction with the overall use of sodium fluorescein.

Detailed description: Thirty patients (n=30) ongoing a total laparoscopic hysterectomy in a tertiary gynecological reference center will be included in this prospective descriptive study.Once hysterectomy is completed, a 10 % solution of sodium fluorescein at a 0,25 ml dose will be injected before performing diagnostic cystoscopy. Time from injection to fluorescent visualization will be recorded as well as coloration density. Adverse events are collected in the operating room, in the recovery room, before patient's discharge and through a home survey.

Eligibility criteria: Inclusion Criteria:

* total laparoscopic hysterectomy

Exclusion Criteria:

* breastfeeding
* renal insufficiency
* Medication: Probenecid, digoxin, quinidine, beta-blocker
* hypersensitivity or intolerance to sodium fluorescein

Primary outcomes:
measure: Quality of Ureteral Efflux Coloration With Sodium Fluorescein Collected With Dedicated Questionnaire
timeFrame: within 15 minutes after the beginning of cystoscopy
measure: Adverse Reaction Related to Sodium Fluorescein Injection
timeFrame: From sodium fluorescein injection to follow-up 2 months after surgery
Secondary outcomes:
measure: Surgeon Satisfaction Regarding Ureteral Efflux Visualization by Filling Out a Dedicated Questionnaire
timeFrame: after cystoscopy (up to 15 min after injection)
Other outcomes:
Locations:
city: Quebec
country: Canada
facility: CHU de Québec
Study officials:
affiliation: CHU de Quebec
name: Philippe Y Laberge, doctorate
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT03468400: Evaluation of the Reliability and Validity of a Diagnostic Sleep Disorders Questionnaire
Official title: Evaluation of the Reliability and Validity of a Diagnostic Sleep Disorders Questionnaire
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Sleep Apnea Syndromes
Insomnia
Insufficient Sleep Syndrome
Circadian Rhythm Disorders
Keywords: sleep disorders
assessment
diagnosis
Lead sponsor: Dayzz Live Well Ltd.
Sponsor class: INDUSTRY
First posted: 2018-03-16
Enrollment: 250
Sex: ALL
Minimum age (years): 21
Maximum age (years): 65
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: ECOLOGIC_OR_COMMUNITY
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: A general community population and clinical population physician-referred for diagnosis and assessment of sleep disorders at a sleep clinic within a large medical center.

Brief summary: The study aims to develop and test a user-friendly, accessible approach to sleep assessment which can function as an initial "triage" of targeted sleep conditions, such as insomnia, insufficient sleep syndrome, sleep apnea syndromes/snoring, and circadian sleep/wake disorders, within the clinical and community population. Specifically, this study will test the validity and reliability of a self-rated, digitized, and cost-effective diagnostic measure with sufficient sensitivity to accurately assess/diagnose common sleep conditions and/or risk for these conditions. Such an approach, would allow for faster assessment of common sleep conditions and disorders, and provide clinical knowledge to the individual, the physician, and if required insurance companies, as to those persons who need more immediate attention or treatment for their sleep condition.


Eligibility criteria: Inclusion Criteria:

Patients aged 21-65 years who are referred to the sleep clinic at Carmel Medical Center and who are capable of filling out an electronic questionnaire in Hebrew.

Exclusion Criteria:

1. Patient age \<21 years or \>65 years.
2. Women who are pregnant or breastfeeding.
3. Nighttime shift-workers.
4. Persons who are unable to provide consent due to mental incapacity.
5. Persons referred for evaluation by Ministry of Transportation (for licensing purposes).

Primary outcomes:
measure: Sleep disorders diagnosis and severity of diagosis
timeFrame: 30-60 minutes
Secondary outcomes:
Other outcomes:
Locations:
city: Baltimore
country: United States
facility: John Hopkins University
state: Maryland
city: Haifa
country: Israel
facility: Carmel Hospital
Study officials:
References:
Clinical trial NCT00442000: Outcomes Comparison of Robotic, Retropubic, and Perineal Prostatectomy
Official title: Outcomes Comparison of Robotic, Retropubic, and Perineal Prostatectomy
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Prostate Cancer
Keywords: Prostate Cancer
Prostatectomy
Lead sponsor: William Beaumont Hospitals
Sponsor class: OTHER
First posted: 2007-03-01
Enrollment: 700
Sex: MALE
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Time perspective: RETROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Patients undergoing prostatectomy at William Beaumont-Royal Oak.

Brief summary: Compare peri-operative and postoperative outcomes of the three different surgical approaches to prostatectomy

Detailed description: Existing data collected from Prostatectomy Database study and Urology Database study will be analyzed. Compare peri-operative and postoperative outcomes of the three different surgical approaches to prostatectomy

Eligibility criteria: Inclusion Criteria:

* 18 years of age
* Radical Prostatectomy at William Beaumont Hospital

Exclusion Criteria:

* Dementia

Primary outcomes:
Secondary outcomes:
Other outcomes:
Locations:
city: Royal Oak
country: United States
facility: William Beaumont Hospital
state: Michigan
Study officials:
affiliation: William Beaumont Hospitals
name: Kevin Feber, M.D.
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT05937100: New Vital Pulpotomy Medications in Primary Molars
Official title: Clinical and Radiographic Evaluation of Hyaluronic Acid and Biodentine as Vital Pulpotomy Medications in Primary Molars: Randomized Controlled Clinical Trial
Study type: INTERVENTIONAL
Overall status: ACTIVE_NOT_RECRUITING
Phase: NA
Conditions: Carious Exposure of Pulp
Keywords: Hyaluronic Acid - Biodentine - Pulpotomy
Lead sponsor: Mansoura University
Sponsor class: OTHER
First posted: 2023-07-10
Enrollment: 48
Sex: ALL
Minimum age (years): 4
Maximum age (years): 7
Standard ages: CHILD
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: Evaluate clinically and radiographically the effect of biodentine and hyaluronic acid (HA) versus formocresol (FC) as pulpotomy medications in primary molars.

Detailed description: Split mouth randomized controlled clinical trial. This study will be conducted on 96 teeth from 48 children in age group 4-7 years and have bilateral lower primary molars indicated for vital pulpotomy procedure. for:

1. Clinical evaluation of biodentine, hyaluronic acid and formocresol groups according to presence of failure criteria at different follow up periods.
2. Radiographic evaluation of biodentine, hyaluronic acid and formocresol groups according to presence of failure criteria at different follow up periods.

Eligibility criteria: Inclusion Criteria:

* -Clinical criteria

  1. Restorable mandibular primary molars with deep carious lesions.
  2. Absence of gingival swelling or sinus tract.
  3. Absence of spontaneous pain
  4. Absence of pain on percussion. B-Radiographic Criteria: Absence of

  <!-- -->

  1. Discontinuity of lamina dura
  2. Internal root resorption.
  3. External root resorption.
  4. inter-radicular or periapical bone destruction (radiolucency)

Exclusion Criteria:

1. Excessive bleeding during pulp amputation.
2. Non vital/necrotic teeth.
3. Any sort of medical history contraindicating the pulp treatment.
4. Teeth approximate exfoliation
5. Patient's guardians are not intending to be part of the study.
6. Retreatment of previously pulpotomy treated molar -

Primary outcomes:
measure: clinically successful pulpotomy
timeFrame: 18 months
measure: radiographically successful pulpotomy
timeFrame: 18 months
Secondary outcomes:
Other outcomes:
Locations:
city: Mansoura
country: Egypt
facility: Dentistry
Study officials:
affiliation: assistant lecturer ,Faculty of Dentistry, Mansoura University B.D.S (2016)
name: Weaam I El-tantawy
role: PRINCIPAL_INVESTIGATOR
affiliation: Professor ,Faculty of Dentistry, Mansoura University
name: Nadia M Farrag
role: STUDY_DIRECTOR
affiliation: Lecturer, Faculty of Dentistry, Mansoura University
name: Hossam E Hammouda
role: STUDY_DIRECTOR
References: