Clinical trial NCT04955535: Screening of Specific Genes for Pigmented Villous Nodular Synovitis
Official title: Screening of Specific Genes for Pigmented Villous Nodular Synovitis
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Pigmented Villonodular Synovitis
Lead sponsor: Peking University Third Hospital
Sponsor class: OTHER
First posted: 2021-07-08
Enrollment: 60
Sex: ALL
Minimum age (years): 18
Maximum age (years): 60
Standard ages: ADULT
Accepts healthy volunteers: no
Observational model: CASE_ONLY
Time perspective: RETROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Patients with "pigmented villonodular synovitis" and "giant cell tumor of tendon sheath"

Brief summary: This study retrospectively analyzed the history of present illness of PVNS patients in our hospital. The enrolled patients were followed up by telephone to follow up their postoperative recovery and living conditions. Take the patient's pathological specimens for immunohistochemical testing, evaluate the relationship between the expression of different molecular targets, clinical manifestations and patient prognosis, and explore new molecular targets related to disease diagnosis and treatment.

Detailed description: This study retrospectively analyzed the symptoms, time of onset, injury history, laboratory examinations, imaging examinations, and intraoperative conditions of PVNS patients in our hospital. The enrolled patients were followed up by telephone to follow up their postoperative recovery and living conditions (VAS score, SF-36 score). Take the patient's pathological specimens for immunohistochemical testing, evaluate the relationship between the expression of different molecular targets, clinical manifestations and patient prognosis, and explore new molecular targets related to disease diagnosis and treatment.

Eligibility criteria: Inclusion Criteria:

1. Clinical diagnosis of pigmented villonodular synovitis.
2. Clinical diagnosis of giant cell tumor of tendon sheath

Exclusion Criteria:

1. No surgical treatment.
2. There were no pathological specimens during the operation.
3. The age of the patient is less than 18 years old or more than 60 years old.
4. The operation record shows nodular type.

Primary outcomes:
measure: Difference of scale score between immunohistochemistry positive group and negative group
timeFrame: One week after surgery
measure: Difference of Visual Analog Score for pain between TNF-α immunohistochemistry positive group and negative group
timeFrame: One week after surgery
measure: Difference of Visual Analog Score for pain between IL-1B immunohistochemistry positive group and negative group
timeFrame: One week after surgery
measure: Difference of SF-36 score between CSF-1 immunohistochemistry positive group and negative group
timeFrame: One week after surgery
measure: Difference of SF-36 score between TNF-α immunohistochemistry positive group and negative group
timeFrame: One week after surgery
measure: Difference of SF-36 score between IL-1B immunohistochemistry positive group and negative group
timeFrame: One week after surgery
Secondary outcomes:
measure: Correlation between basic demographic characteristics and scale scores
timeFrame: One week after surgery
Other outcomes:
Locations:
city: Beijing
country: China
facility: Institute of Sports Medicine, Peking University Third Hospital, Beijing Key Laboratory of Sports Injuries， Beijing, China
state: Beijing
Study officials:
affiliation: Peking Yniversity Third Hospital
name: Yingfang Ao, Prof.
role: STUDY_CHAIR
References: