louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT00523185: A Comparison of Lorazepam and Diazepam in the Treatment of Alcohol Withdrawal
Official title: A Comparison of Lorazepam and Diazepam in the Treatment of Alcohol Withdrawal
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Alcohol Withdrawal
Keywords: alcohol withdrawal
lorazepam
diazepam
Lead sponsor: Stanford University
Sponsor class: OTHER
First posted: 2007-08-31
Enrollment: 55
Sex: ALL
Minimum age (years): 19
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The purpose of this study is to compare the efficacy of two commonly used medications in the treatment of alcohol withdrawal, diazepam and lorazepam.

Detailed description: Despite the frequent use of benzodiazepines for the treatment of alcohol withdrawal, studies comparing the efficacy of long and short half-life benzodiazepines in the treatment of alcohol withdrawal have shown mixed results. Due to the conflicting nature of published reports, clinicians have no clear indication as to which type of agent is preferable. The purpose of this study is to compare the efficacy of two commonly accepted medications in the treatment of alcohol withdrawal, diazepam and lorazepam, which are long and short half-life benzodiazepines, respectively.

Eligibility criteria: Inclusion Criteria:

* Clinical diagnosis of alcohol withdrawal
* History of alcohol use within 24 hours
* Ability to consent to participate in the study

Exclusion Criteria:

* Unwillingness to participate in the study
* Active abuse of other CNS depressants
* Acute intoxication with a CNS activating agent
* Severe hepatic dysfunction
* Pregnancy
* History of dementia

Primary outcomes:
measure: The primary outcome measures include serial measures of vital signs and scores on the Clinical Institute Withdrawal Assessment for Alcohol-Revised scale (CIWA-Ar), a widely used scale that monitors alcohol withdrawal symptoms.
timeFrame: one to two weeks
Secondary outcomes:
measure: Secondary outcome measures include total benzodiazepine use.
timeFrame: one to two weeks
Other outcomes:
Locations:
city: Palo Alto
country: United States
facility: Palo Alto Veterans Affairs Hospital System
state: California
city: Stanford
country: United States
facility: Stanford Hospital and Clinics
state: California
Study officials:
affiliation: Stanford University
name: Jose R Maldonado, MD
role: PRINCIPAL_INVESTIGATOR
References:
citation: Maldonado JR, Nguyen LH, Schader EM, Brooks JO 3rd. Benzodiazepine loading versus symptom-triggered treatment of alcohol withdrawal: a prospective, randomized clinical trial. Gen Hosp Psychiatry. 2012 Nov-Dec;34(6):611-7. doi: 10.1016/j.genhosppsych.2012.06.016. Epub 2012 Aug 13.
Clinical trial NCT03491085: Role of Antibiotics Post Tonsillectomy
Official title: Study Of The Antibiotic Role In Post Tonsillectomy Complications
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: PHASE1
PHASE2
Conditions: Tonsillectomy
Lead sponsor: Assiut University
Sponsor class: OTHER
First posted: 2018-04-09
Enrollment: 200
Sex: ALL
Minimum age (years): 1
Maximum age (years): 18
Standard ages: CHILD
ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: CROSSOVER
Primary purpose: TREATMENT

Brief summary: morbidity after tonsillictomy remains asignificant problem therefore they recommend prophylactic antibiotics to reduce it.in the other hand, the overuse of antimicrobial agents can lead to antimicrobial resistance ,adverse drug events,and unnecessary cost.so,the effectiveness and necessity of antibiotic following tonsillictomy needs to be studied .


Eligibility criteria: Inclusion Criteria:

200 patients who are scheduled for tonsillectomy with or without adenoidectomy, and their age are less than 18 years old of either gender will be included in our study

Exclusion Criteria:

* 1-Patients age ≥ 18 years.

  2-Trials in which antibiotics was administrated locally or used in the immediate preoperative period (within seven days before surgery).

  3. Medical comorbidity requiring treatment with antibiotics e.g. Rheumatic heart disease

  4-Patients undergoing the following procedures:
  1. Unilateral tonsillectomy or biopsy.
  2. Tonsillectomy for known carcinoma.
  3. Tonsillectomy in conjunction with palatal surgery.
  4. Hot tonsillectomy for tonsillar abscess

Primary outcomes:
measure: compare the morbidity after tonsillectomy between the group which receive antibiotics and the other group which not receive antibiotics
timeFrame: 2 years
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
References:
citation: Patel A, Foden N, Rachmanidou A. Is weekend surgery a risk factor for post-tonsillectomy haemorrhage? J Laryngol Otol. 2016 Aug;130(8):763-7. doi: 10.1017/S0022215116008161. Epub 2016 Jun 13.
Clinical trial NCT03168685: Hemophilia Mobile App Usability Pilot
Official title: Bayer/HITLAB - Hemophilia Mobile App Usability Pilot
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Hemophilia
Keywords: smartphones
clinical trials
weight
actigraph
tracking
hemophilia
Lead sponsor: Healthcare Innovation Technology Lab
Sponsor class: INDUSTRY
Collaborators: name: Bayer
First posted: 2017-05-30
Enrollment: 20
Sex: ALL
Minimum age (years): 18
Maximum age (years): 63
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: DEVICE_FEASIBILITY

Brief summary: The purpose of this study is to evaluate the utility and user experience of a smart phone app for people with medical conditions, used in conjunction with an ActiGraph wearable device and a connected scale.

Detailed description: HITLAB will conduct a segmented rapid user acceptance study ("rapid UX study") of a smart phone app and an actigraphy device with a connected scale. During the first segment, of one month's duration, subjects will use the app, actigraphy device, and scale. Next, over an interphase period of up to 6 weeks, subjects will only use the app. During this time, the app will be modified based on data collected during the first segment. Finally, during the second period, also of one month's duration, subjects will use the modified app, actigraphy device, and scale.

Eligibility criteria: Inclusion Criteria:

1. You own an iPhone or a Samsung (S5 or higher) smartphone
2. Your age is between 18 and 63 years
3. You reside in the New York metropolitan area
4. You are able to read, write, and speak English
5. You have participated in a concluded clinical trial in the past two years

Exclusion Criteria:

1. You do not own an iPhone or a Samsung (S5 or higher) smartphone
2. Your age is not between 18 and 63 years
3. You do not reside in the New York metropolitan area
4. You are not able to read, write, and speak English
5. You have not participated in a concluded clinical trial in the past two years

Primary outcomes:
measure: Usage of the SureSource Engage application as assessed by ActiLife software
timeFrame: 128 days
measure: Device usability as assessed by the System Usability Scale (SUS)
timeFrame: 128 days
Secondary outcomes:
Other outcomes:
Locations:
city: New York
country: United States
facility: Healthcare Innovation and Technology Lab
state: New York
Study officials:
affiliation: Healthcare Innovation Technology Lab
name: Stan Kachnowski, PhD, MPA
role: PRINCIPAL_INVESTIGATOR
affiliation: Healthcare Innovation Technology Lab
name: Ryan Dammerman, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT05749185: High Versus Standard Voltage Pulsed Radiofrequency for Cervical Nerve Roots Injection in Refractory Chronic Unilateral Cervical Radicular Pain
Official title: Comparison Between the Effectiveness of Ultrasound-Guided High Voltage Pulsed Radiofrequency Versus Standard Voltage Pulsed Radiofrequency for Cervical Nerve Roots in Patients With Refractory Chronic Unilateral Cervical Radicular Pain
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Chronic Cervical Radiculopathy
Lead sponsor: Minia University
Sponsor class: OTHER
First posted: 2023-03-01
Enrollment: 100
Sex: ALL
Minimum age (years): 20
Maximum age (years): 70
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The goal of this interventional study is to compare efficacy of either standard versus supra-voltage radiofrequency cervical epidural injection in pain alleviation in population with chronic cervical radiculopathy.


Eligibility criteria: Inclusion Criteria:

* Age between 20 and 70 years, both genders.
* American Society of Anesthesiologists (ASA) physical status grades I or II.
* Unilateral cervical radicular pain secondary to cervical disc prolapse affecting single nerve root which was refractory to conventional conservative and physiotherapy measures for 12 weeks or more.
* All candidates received 1 millilitre of 2% lidocaine via an ultrasound-guided diagnostic nerve block and informed at least 50% momentary reduction of their pain.
* Diagnosis was confirmed by cervical MRI and nerve conduction tests.

Exclusion Criteria:

* Refusal to participate.
* Cervical radiculopathy pain recurrence after surgery.
* Previous attempt of radiofrequency ablation.
* Concomitant coagulopathic state ( decompensated liver disease, clopidogrel use) .
* Metastatic lesion in the cervical vertebral column.

Primary outcomes:
measure: visual analogue score
timeFrame: pre-treatment, 1,3, and 6 month after intervention
Secondary outcomes:
measure: Neck disability index
timeFrame: pre-treatment, 1,3 and 6 months after intervention
measure: Incidence of procedure related adverse events
timeFrame: 6 hours after the procedure
Other outcomes:
Locations:
city: Fayoum
country: Egypt
facility: Mina Raouf
Study officials:
References:
Clinical trial NCT04134585: Promoting Fall Prevention Workshops
Official title: Promoting Fall Prevention Workshops for Individuals Aged 60 and Over: an Exploratory Study.
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Sedentary Behavior
Aging
Keywords: Fall
Prevention
Seniors
Physical activity
Interviews
Lead sponsor: Centre Hospitalier Universitaire de Saint Etienne
Sponsor class: OTHER
Collaborators: name: Crédit Agricole Loire / Haute-Loire
name: Jean Monnet University
First posted: 2019-10-22
Enrollment: 19
Sex: ALL
Minimum age (years): 60
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: People aged 60 and over.

Brief summary: Physical Activity (PA) is recognized as the most effective method to prevent falls in the elderly. Yet despite there being a consensus now that Physical Activity (PA) is effective in practice, there remain many obstacles to participation resulting in PA approaches designed to prevent falls actually only benefiting a limited number of elderly subjects.

Detailed description: It's a qualitative study. The target population was people aged 60 and over who had refused to participate in fall prevention workshops.

The study covered three different French departments. A total of 19 semi-structured interviews were conducted over a period of 5 months.

The analysis of reports revealed there were multiple motives for not participating in the balance workshops. The current means of promoting these fall prevention workshops are not adapted. Finally, the social experience provided by the program was identified to be the principal motivator for encouraging the interviewed subjects to participate.

Eligibility criteria: Inclusion Criteria:

* People who received a proposal to participate in our workshop and who denied it
* People living in one of the three departments of the study (Loire, Haute-Loire and Rhône)

Exclusion Criteria:

- People who refused to participate to the study.

Primary outcomes:
measure: Correlation between physical activity degree, aging and illness
timeFrame: Month: 5
Secondary outcomes:
measure: Analysis representations of physical activity.
timeFrame: Month: 5
measure: Analysis reluctance to participate in physical activity sessions.
timeFrame: Month: 5
measure: Analysis motivation to participate in physical activity sessions.
timeFrame: Month: 5
measure: Analysis facilitators who can help them overcome these barriers
timeFrame: Month: 5
Other outcomes:
Locations:
city: Saint-Étienne
country: France
facility: Chu Saint-Etienne
Study officials:
affiliation: Jean Monnet University
name: Luc GOETHALS, Doctoral student
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT05481632: Validating the Safety and Effectiveness of ENDOANGEL Lower Gastrointestinal Endoscope Image Auxiliary Diagnostic Software
Official title: Validating the Safety and Effectiveness of ENDOANGEL Lower Gastrointestinal Endoscope Image Auxiliary Diagnostic Software
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Intestinal Polyps
Lead sponsor: Ruijin Hospital
Sponsor class: OTHER
Collaborators: name: Peking University Cancer Hospital & Institute
name: Wuhan Central Hospital
First posted: 2022-08-01
Enrollment: 1360
Sex: ALL
Minimum age (years): 18
Maximum age (years): 75
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: DIAGNOSTIC

Brief summary: To evaluate the safety and effectiveness of ENDOANGEL Lower Gastrointestinal Endoscope Image Auxiliary Diagnostic Software developed and manufactured by Wuhan ENDOANGEL Medical Technology Co., Ltd.


Eligibility criteria: Inclusion Criteria:

* 18 years old ≤ age ≤ 75 years old, male or female;
* Subjects with colonoscopy diagnosis and screening needs;
* Sign the Written Informed Consent Form;
* With full capacity for civil conduct.

Exclusion Criteria:

* History of acute myocardial infarction (within 6 months), severe heart, liver, and renal insufficiency or mental disease;
* Patients who are taking aspirin, warfarin, and other anticoagulants;
* Patients with inflammatory bowel disease, or polyposis syndromes, or confirmed or highly suspected colon cancer;
* History of colorectal surgery;
* Patients with familial adenomatous polyposis;
* Pregnant women (if the subject is a woman of reproductive age and cannot confirm whether she is pregnant, a pregnancy test is required);
* Patients who are participating in clinical trials of other drugs or medical devices;
* Patients who are not eligible to participate in this clinical trial in the opinion of the investigator.

Primary outcomes:
measure: sensitivity of polyps identification
timeFrame: 3 months
measure: specificity of polyps identification
timeFrame: 3 months
Secondary outcomes:
measure: Polyp detection rate
timeFrame: 3 months
Other outcomes:
Locations:
city: Shanghai
country: China
facility: Ruijin Hospital, Shanghai Jiaotong University School of Medicine
state: Shanghai
Study officials:
References:
Clinical trial NCT06335732: Prevalenc Of Lumbosacral Radiculopathy Among Physiotherapists Of Pediatric Rehabilitation OF PEDIATRIC REHABILITATION
Official title: Prevalenc Of Lumbosacral Radiculopathy Among Physiotherapists Of Pediatric Rehabilitation
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Prevalence, Lumbosacral Radiculopathy
Keywords: Prevalence, Lumbosacral radiculopathy, Low back pain.
Lead sponsor: October 6 University
Sponsor class: OTHER
First posted: 2024-03-28
Enrollment: 200
Sex: ALL
Minimum age (years): 25
Maximum age (years): 40
Standard ages: ADULT
Accepts healthy volunteers: yes
Observational model: CASE_CONTROL
Time perspective: CROSS_SECTIONAL
Sampling method: PROBABILITY_SAMPLE
Study population: Two hundred pediatric physiotherapists from both genders were participated in the current study. They were selected randomly from the Outpatient Clinic of pediatric physiotherapists of Hospitals of Ministry of Health in Cairo-Egypt, the duration of this study was six months started from December 2022 to June 2023.

Brief summary: Determine the prevalence of lumbosacral radiculopathy among pediatric physiotherapists in the ministry of health in Cairo, Egypt.

Detailed description: the aim of current study was to determine the prevalence of lumbosacral radiculopathy among pediatric physiotherapists in the ministry of health in Cairo, Egypt.

Eligibility criteria: Inclusion Criteria:

* a) The age of the subjects ranged from 25-40 years old; b) all subjects working in Ministry of Health in Cairo-Egypt; c) BMI \<30

Exclusion Criteria:

* they were with history of bone disease, renal, liver or endocrinal disorders; b) having lumbosacral radiculopathy before working as pediatric physiotherapists, c) having trauma in back or accident and pregnant pediatric physiotherapists

Primary outcomes:
measure: The Roland-Morris disability scale (RMS)
timeFrame: up to 6 months
measure: Straight Leg Raising (SLR)
timeFrame: up to 6 months
Secondary outcomes:
Other outcomes:
Locations:
city: Cairo
country: Egypt
facility: Kerolous Ishak Shehata
Study officials:
References:
Clinical trial NCT01755832: Heated Pool Exercise Groups for Patients With Rheumatic Diseases
Official title: Better Everyday-life With Heated Pool Exercise Groups for Patients With Inflammatory Rheumatic Diseases
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Rheumatic Disease
Keywords: inflammatory rheumatic joint disease
text message
> 18 years
Norwegian speaking
Lead sponsor: National Resource Center for Rehabilitation in Rheumatology
Sponsor class: OTHER
First posted: 2012-12-24
Enrollment: 36
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Patients with inflammatory rheumatic joint diseases with a medical referral to group exercises in heated pool.

Brief summary: The purpose of this study is to investigate the effects of heated pool group exercises for patients with inflammatory rheumatic diseases with regard to symptoms (pain, fatigue, stiffness and ability to carry out daily activities).

Detailed description: The patients receive text messages on mobile phones twice a week for circa 40 weeks. The text messages ask for pain, fatigue, stiffness and ability to carry out everyday activities. The patients should respond with a number from 0 to 10, where 0 is no symptoms/no hindering of activity and 10 is worst symptoms/worst hindering of activity.

Eligibility criteria: Inclusion Criteria:

* Referral from a medical doctor to group exercises in heated pool
* Inflammatory rheumatic joint disease
* \> 18 years
* Stable disease
* Mobile phone owner
* Understand and use text messages on mobile phones

Exclusion Criteria:

* Independent living
* Joint surgery previous to the study start

Primary outcomes:
measure: Activity
timeFrame: 40 weeks
measure: Pain
timeFrame: 40 weeks
measure: Fatigue
timeFrame: 40 weeks
measure: Stiffness
timeFrame: 40 weeks
Secondary outcomes:
Other outcomes:
Locations:
city: Oslo
country: Norway
facility: National resource center for rehabilitation in rheumatology
Study officials:
affiliation: National resource centre for rehabilitation in rheumatology
name: Anne Christie, Ph.D.
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT02988037: Adapted Dialectical Behaviour Therapy for Adolescents With Deliberate Self-Harm: A Pre-post Observational Study
Official title: Adapted Dialectical Behaviour Therapy for Adolescents With Deliberate Self-Harm: A Pre-post Observational Study
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Deliberate Self Harm
Borderline Personality Disorder
Lead sponsor: University of Ottawa
Sponsor class: OTHER
First posted: 2016-12-09
Enrollment: 33
Sex: ALL
Minimum age (years): 15
Maximum age (years): 18
Standard ages: CHILD
ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: TREATMENT

Brief summary: The investigators conducted a pre-post naturalistic study regarding changes observed associated with a 15-week course of an adapted form of dialectical behaviour therapy for adolescents. We measured frequency of self-harm prior to treatment and after treatment using the Self-Injurious Thoughts and Behaviors Interview. We also measured changes using the Suicide Ideation Questionnaire, Life Problems Inventory, Resiliency Scale for Children and Adolescents.


Eligibility criteria: Inclusion Criteria:

* features of Borderline Personality Disorder (BPD) and recent history of self-injurious thoughts or behaviours.

  1. meeting criteria for BPD or for subsyndromal variants of BPD, and (2) self-injurious thoughts and behaviours defined as: (a) a score \> 30 on the Suicidal Ideation Questionnaire (SIQ) OR (b) Deliberate Self-harm in the 4 months prior to treatment

Exclusion Criteria:

* severe substance use (where residential treatment would be indicated), florid psychosis and developmental delay

Primary outcomes:
measure: Change in Frequency of Deliberate Self-harm
timeFrame: 15 weeks
Secondary outcomes:
measure: Suicidal Ideation Questionnaire
timeFrame: 15 weeks
measure: Life Problems Inventory
timeFrame: 15 weeks
measure: Resiliency Scales for Children and Adolescents
timeFrame: 15 weeks
measure: Attrition from therapy
timeFrame: 15 weeks
Other outcomes:
Locations:
Study officials:
References:
Clinical trial NCT03211637: Wounds Protocol at Family Health Strategy Units in a Rio Grande do Sul Countryside Town
Official title: Implementing and Assessing an Wounds Protocol at Family Health Strategy Units in a Rio Grande do Sul Countryside Town
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Chronic Vascular Wounds in Adults
Keywords: nursing care
skin lesions
wound healing
varicose ulcers
Lead sponsor: Hospital Nossa Senhora da Conceicao
Sponsor class: OTHER
First posted: 2017-07-07
Enrollment: 20
Sex: ALL
Minimum age (years): 60
Maximum age (years): 90
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: Evaluate the process for implementing a wound protocol for lesion control and cost-effectiveness in the context of the Family Health Strategy in the city of Santa Cruz do Sul, Brazil.


Eligibility criteria: Inclusion Criteria:

* Presenting vascular (venous, arterial or mixed) ulcers for over 1 year;
* Be available to have wounds dressed at the healthcare unit;
* Be a patient registered with the Family Health Strategy teams.

Exclusion Criteria:

* Have some condition rendering the patient unable to go to the unit, such as being bedridden or having had a lower limb amputated;
* Having decompensated diabetes mellitus;
* Having move away from the Family Health Strategy unit's coverage area.

Primary outcomes:
measure: Lesion remission by measuring the surface area of the wound
timeFrame: one month
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
References: