Clinical trial NCT03089996: Evaluation of Clinical Approaches to Accelerate Orthodontic Tooth Movement
Official title: Piezocision, Corticotomy and Micro-ostoeperforations to Accelerate Orthodontic Tooth Movement
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Orthodontic Tooth Movement
Keywords: piezocision
corticotomy
Gingival Crevicular Fluid
Micro-osteperforations
Lead sponsor: Pontifícia Universidade Católica de Minas Gerais
Sponsor class: OTHER
Collaborators: name: Fundação de Amparo à Pesquisa do estado de Minas Gerais
First posted: 2017-03-24
Enrollment: 45
Sex: ALL
Minimum age (years): 15
Maximum age (years): 45
Standard ages: CHILD
ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: This study will compare the techniques of piezocision and alveolar corticotomies in accelerating orthodontic retraction movement of canines. In a second phase, this clinical trial will evaluate the effectiveness of micro-osteoperforations in accelerating the retraction of maxillary incisors.

Detailed description: The first phase will consist of a split-mouth study in patients who require the extraction of the first premolars to correct malocclusion. The canine will be retracted using corticotomy and piezocision surgical techniques, as well as without any intervention, being this the control side. In addition, it will be evaluated the inflammatory biomarkers present in the gingival crevicular sulcus during the dental movement, as well as data related to pain and discomfort. The second phase will evaluate the effects of micro-osteoperforations in the retraction of maxillary incisors. The following parameters will be evaluated in the upper arch: anteroposterior incisors and first molars displacement, space closure, inclination and length of central incisors.

Eligibility criteria: Inclusion Criteria:

* Patient with orthodontic need for bilateral upper first premolar extraction.
* Adequate dento-oral health
* ASA I and ASA II
* Compliance with clinic visits every 2 weeks

Exclusion Criteria:

* History of periodontal disease
* Smokers
* Altered bone metabolism (e.g., due to anti-resorptive drug, steroid or immunosuppressant use)
* Pregnancy
* Presence of cleft or any syndrome

Primary outcomes:
measure: Orthodontic Canine Retraction Rate
timeFrame: Up to 6 months
measure: Anteroposterior displacement of the upper incisors
timeFrame: Up to 4 months
measure: Space closure
timeFrame: Up to 4 months
Secondary outcomes:
measure: Duration of the effect of the surgical procedures
timeFrame: Up to 6 months
measure: Evaluation of biomarkers
timeFrame: Up to 6 months
measure: Patient Pain and discomfort
timeFrame: Up to 6 months
measure: First molars anchorage loss
timeFrame: Up to 4 months
measure: Changes of the inclination of the central incisors
timeFrame: Up to 4 months
measure: Changes of the length of the central incisors
timeFrame: Up to 4 months
Other outcomes:
Locations:
city: Belo Horizonte
country: Brazil
facility: Pontifícia Universidade Católica de Minas Gerais
state: MG
Study officials:
affiliation: Pontifícia Universidade Católica de Minas Gerais
name: Rodrigo V Soares, Phd
role: STUDY_DIRECTOR
References:
citation: Fernandes LSDMCP, Figueiredo DSF, Oliveira DD, Houara RG, Rody WJ Jr, Gribel BF, Soares RV. The effects of corticotomy and piezocision in orthodontic canine retraction: a randomized controlled clinical trial. Prog Orthod. 2021 Oct 4;22(1):37. doi: 10.1186/s40510-021-00367-3.