Clinical trial NCT04888585: Study to Evaluate Adverse Events and Change in Disease Activity in Participants Between 18 to 75 Years of Age Treated With Subcutaneous (SC) Injections of ABBV-154 for Moderately to Severely Active Rheumatoid Arthritis (RA)
Official title: A Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Safety and Efficacy of ABBV-154 in Subjects With Moderately to Severely Active Rheumatoid Arthritis With Inadequate Response to Biologic and/or Targeted Synthetic Disease-Modifying Anti-Rheumatic Drugs (b/tsDMARDs)
Study type: INTERVENTIONAL
Overall status: TERMINATED
Phase: PHASE2
Conditions: Rheumatoid Arthritis (RA)
Keywords: Rheumatoid Arthritis (RA)
ABBV-154
AIM-RA
Lead sponsor: AbbVie
Sponsor class: INDUSTRY
First posted: 2021-05-17
Enrollment: 473
Sex: ALL
Minimum age (years): 18
Maximum age (years): 75
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: Rheumatoid Arthritis (RA) is an inflammatory disease of the joints causing pain, stiffness, swelling and loss of joint function. This study evaluated how safe and effective ABBV-154 is in participants treated for moderately to severely active RA. Adverse events and change in the disease activity were assessed.

ABBV-154 is an investigational drug being evaluated for the treatment of RA. Study doctors placed the participants in 1 of 5 treatment groups or arms; each arm received a different treatment. There was a 1 in 5 chance that participants were assigned to placebo. Participants 18-75 years of age with moderate to severe RA were enrolled. Around 425 participants were to be enrolled in the study at approximately 270 sites worldwide.

The study was comprised of a 12 week placebo-controlled period, a double-blind long term extension (LTE) period 1 of 66 weeks, a LTE period 2 of 104 weeks and a follow-up visit 70 days after the last dose of the study drug. In the LTE period 1, participants in the placebo group were re-randomized to receive ABBV-154 at 1 of 2 different doses SC every other week (EOW). Other participants remained on their previous dose and dosing regimen of ABBV-154.

There may have been a higher treatment burden for participants in this trial compared to their standard of care. Participants attended regular visits during the study at a hospital or clinic. The effect of the treatment was checked by medical assessments, blood tests, and side effects, and completing questionnaires.

Detailed description: Participants were randomly assigned at a ratio of 1:1:1:1:1 to ABBV-154 at either 40 mg, 150 mg, 340 mg, subcutaneously (SC) EOW; 340 mg SC every 4 weeks (E4W); or placebo SC EOW. Randomization was stratified by baseline glucocorticoid (yes/no); number of prior failed biologic and/or targeted synthetic disease-modifying anti-rheumatic drugs (b/tsDMARDs) (1; 2 or more); and prior anti-TNF failure (yes/no) and if yes, further stratification by prior adalimumab use (yes/no).

After 12 weeks, participants receiving placebo were re-randomized to receive ABBV-154 150 mg SC EOW or 340 mg SC EOW for the long-term extension (LTE) periods. At re-randomization, participants were stratified by baseline glucocorticoid use (yes/no) and prior adalimumab use (yes/no). Participants from the other dose groups were to continue with their respective dose and dosing regimen.

The primary analysis was conducted after all ongoing participants completed Week 12 or withdrew from the study. A final analysis was to be conducted after all participants completed LTE period 2 and a safety follow-up visit or withdrew from the study. The study was terminated before any participants entered LTE Period 2.

Eligibility criteria: Inclusion Criteria:

* Clinical diagnosis of rheumatoid arthritis(RA) with fulfillment of the 2010 American College of Rheumatology (ACR)/European League Against Rheumatism (EULAR) classification criteria for RA.
* Participant has \>= 6 swollen joints (based on 66 joint count) and \>=6 tender joints (based on 68 joint count) at baseline.
* Participant must have had an inadequate response to at least one prior biologic and/or targeted synthetic disease-modifying anti-rheumatic drugs (b/tsDMARDs) treatment for RA.
* Participants must be on stable dose of methotrexate (MTX).

Exclusion Criteria:

- Participant discontinued prior adalimumab therapy due to intolerability or toxicity.

Primary outcomes:
measure: Achievement of 50% Improvement as Measured by American College of Rheumatology Response Criteria (ACR50) at Week 12
timeFrame: Week 12
Secondary outcomes:
measure: Change From Baseline in Disease Activity Score (DAS) 28 (CRP) at Week 12
timeFrame: Baseline to Week 12
measure: Change in Clinical Disease Activity Index (CDAI) at Week 12
timeFrame: Baseline to Week 12
measure: Percentage of Participants Achieving American College of Rheumatology 20% (ACR20) Response at Week 12
timeFrame: Week 12
measure: Percentage of Participants Achieving American College of Rheumatology 70% (ACR70) Response at Week 12
timeFrame: Week 12
measure: Percentage of Participants Achieving Low Disease Activity (LDA) Defined by DAS28 (CRP) <= 3.2 at Week 12
timeFrame: Week 12
measure: Percentage of Participants Achieving LDA Defined by CDAI <= 10 at Week 12
timeFrame: Week 12
measure: Percentage of Participants Achieving Clinical Remission (CR) Defined by DAS28 (CRP) < 2.6 at Week 12
timeFrame: Week 12
measure: Percentage of Participants Achieving CR Defined by CDAI <= 2.8 at Week 12
timeFrame: Week 12
measure: Change From Baseline in the Health Assessment Questionnaire Disability Index (HAQ-DI) to Week 12
timeFrame: Baseline to Week 12
Other outcomes:
Locations:
city: Phoenix
country: United States
facility: Elite Clinical Studies, LLC /ID# 228227
state: Arizona
city: Jonesboro
country: United States
facility: Arthritis and Rheumatism Associates /ID# 228201
state: Arkansas
city: Fullerton
country: United States
facility: Providence Medical Foundation /ID# 228104
state: California
city: Huntington Beach
country: United States
facility: Care Access Research, Huntington Beach /ID# 228163
state: California
city: La Mesa
country: United States
facility: Purushotham & Akther Kotha MD, Inc /ID# 228120
state: California
city: La Palma
country: United States
facility: Arthritis & Osteo Medical Ctr /ID# 228239
state: California
city: Los Angeles
country: United States
facility: Pacific Arthritis Care Center - Los Angeles /ID# 229330
state: California
city: Northridge
country: United States
facility: California Medical Research Associates /ID# 230131
state: California
city: Poway
country: United States
facility: Arthritis Care And Research Center ACRC /ID# 230099
state: California
city: San Leandro
country: United States
facility: East Bay Rheumatology Medical /ID# 228099
state: California
city: Thousand Oaks
country: United States
facility: Millennium Clinical Trials /ID# 230618
state: California
city: Torrance
country: United States
facility: The Lundquist Institute at Harbor-UCLA Medical Center /ID# 228241
state: California
city: Tujunga
country: United States
facility: Medvin Clinical Research /ID# 228181
state: California
city: Upland
country: United States
facility: Inland Rheum & Osteo Med Grp /ID# 228204
state: California
city: Woodland Hills
country: United States
facility: Comprehensive Rheumatology Center /ID# 230132
state: California
city: Denver
country: United States
facility: Denver Arthritis Clinic /ID# 228172
state: Colorado
city: Bridgeport
country: United States
facility: New England Research Associates, LLC /ID# 230127
state: Connecticut
city: Stamford
country: United States
facility: Stamford Therapeutics Consorti /ID# 229214
state: Connecticut
city: Lewes
country: United States
facility: Delaware Arthritis /ID# 229413
state: Delaware
city: Boca Raton
country: United States
facility: Rheumatology Associates of South Florida (RASF) - Clinical Research /ID# 228229
state: Florida
city: Brandon
country: United States
facility: Bay Area Arthritis and Osteo /ID# 228075
state: Florida
city: Clearwater
country: United States
facility: Clinical Research of West Florida, Inc /ID# 228128
state: Florida
city: Daytona Beach
country: United States
facility: International Medical Research /ID# 228069
state: Florida
city: DeBary
country: United States
facility: Omega Research Debary, LLC /ID# 228293
state: Florida
city: Hialeah
country: United States
facility: Neoclinical Research /ID# 228753
state: Florida
city: Jacksonville
country: United States
facility: University of Florida /ID# 228242
state: Florida
city: Miami
country: United States
facility: Lakes Research, LLC /ID# 228665
state: Florida
city: Miami
country: United States
facility: University of Miami /ID# 228737
state: Florida
city: New Port Richey
country: United States
facility: Suncoast Clinical Research /ID# 228237
state: Florida
city: Orlando
country: United States
facility: Omega Research Group /ID# 229966
state: Florida
city: Orlando
country: United States
facility: HMD Research LLC /ID# 228185
state: Florida
city: Ormond Beach
country: United States
facility: Millennium Research /ID# 228183
state: Florida
city: Palm Harbor
country: United States
facility: Arthritis Center, Inc. /ID# 228209
state: Florida
city: Saint Petersburg
country: United States
facility: BayCare Medical Group /ID# 228289
state: Florida
city: Tamarac
country: United States
facility: West Broward Rheumatology Associates /ID# 228603
state: Florida
city: Tampa
country: United States
facility: Clinical Research of West Florida - Tampa /ID# 228186
state: Florida
city: Winter Park
country: United States
facility: Conquest Research /ID# 230560
state: Florida
city: Zephyrhills
country: United States
facility: Florida Medical Clinic /ID# 228236
state: Florida
city: Atlanta
country: United States
facility: Arthritis and Rheumatology /ID# 228743
state: Georgia
city: Decatur
country: United States
facility: Jefrey D. Lieberman, MD, P.C. /ID# 230129
state: Georgia
city: Gainesville
country: United States
facility: Arthritis Center of North GA /ID# 228769
state: Georgia
city: Marietta
country: United States
facility: Atlanta Research Center for Rheumatology /ID# 230430
state: Georgia
city: Chicago
country: United States
facility: Great Lakes Clinical Trials /ID# 228699
state: Illinois
city: Schaumburg
country: United States
facility: Greater Chicago Specialty Physicians /ID# 228282
state: Illinois
city: Skokie
country: United States
facility: Clinic of Robert Hozman/Clinical Investigation Specialists /ID# 228174
state: Illinois
city: Springfield
country: United States
facility: Springfield Clinic /ID# 228124
state: Illinois
city: Granger
country: United States
facility: Beacon Medical Group Clinical Research /ID# 229153
state: Indiana
city: Iowa City
country: United States
facility: University of Iowa Hospitals and Clinics /ID# 229217
state: Iowa
city: Paducah
country: United States
facility: Four Rivers Clinical Research /ID# 230109
state: Kentucky
city: Monroe
country: United States
facility: The Arthritis & Diabetes Clinic, Inc. /ID# 228221
state: Louisiana
city: Cumberland
country: United States
facility: Klein and Associates MD /ID# 230145
state: Maryland
city: Hagerstown
country: United States
facility: Klein and Associates MD - Hagerstown /ID# 230143
state: Maryland
city: Wheaton
country: United States
facility: The Center for Rheumatology and Bone Research /ID# 228617
state: Maryland
city: Grand Blanc
country: United States
facility: AA Medical Research Center - Grand Blanc /ID# 228604
state: Michigan
city: Lansing
country: United States
facility: Advanced Rheumatology, PC /ID# 228684
state: Michigan
city: Lansing
country: United States
facility: June DO, PC /ID# 229838
state: Michigan
city: Hattiesburg
country: United States
facility: Arthritis Associates /ID# 230188
state: Mississippi
city: Tupelo
country: United States
facility: Rheumatology Consultants - Clinical Research /ID# 229208
state: Mississippi
city: Saint Louis
country: United States
facility: Clayton Medical Associates, P.C. dba Saint Louis Rheumatology /ID# 228283
state: Missouri
city: Saint Louis
country: United States
facility: West County Rheumatology /ID# 228102
state: Missouri
city: Kalispell
country: United States
facility: Logan Health Research /ID# 228273
state: Montana
city: Las Vegas
country: United States
facility: Advanced Biomedical Research of America /ID# 228596
state: Nevada
city: Las Vegas
country: United States
facility: Innovative Health Research /ID# 229209
state: Nevada
city: Freehold
country: United States
facility: Arthritis and Osteoporosis Associates /ID# 229418
state: New Jersey
city: Voorhees
country: United States
facility: Arthritis Rheumatic and Back Disease Associates. P.A. /ID# 228602
state: New Jersey
city: Albuquerque
country: United States
facility: Albuquerque Center For Rheumatology /ID# 228709
state: New Mexico
city: Albuquerque
country: United States
facility: Albuquerque Clinical Trials, Inc /ID# 228925
state: New Mexico
city: Las Cruces
country: United States
facility: Arthritis and Osteo Assoc /ID# 228662
state: New Mexico
city: Orchard Park
country: United States
facility: Buffalo Rheumatology and Medicine - Orchard Park /ID# 228710
state: New York
city: Potsdam
country: United States
facility: St. Lawrence Health System /ID# 229508
state: New York
city: Charlotte
country: United States
facility: DJL Clinical Research, PLLC /ID# 230133
state: North Carolina
city: Leland
country: United States
facility: Cape Fear Arthritis Care /ID# 228747
state: North Carolina
city: Salisbury
country: United States
facility: PMG Research of Salisbury /ID# 230627
state: North Carolina
city: Minot
country: United States
facility: Trinity Health Med Arts Clinic /ID# 228202
state: North Dakota
city: Cincinnati
country: United States
facility: University of Cincinnati /ID# 229212
state: Ohio
city: Middleburg Heights
country: United States
facility: Paramount Medical Research Con /ID# 228254
state: Ohio
city: Toledo
country: United States
facility: Arthritis Assoc of NW Ohio /ID# 228936
state: Ohio
city: Oklahoma City
country: United States
facility: Arthritis and Rheumatology Center of Oklahoma /ID# 228975
state: Oklahoma
city: Oklahoma City
country: United States
facility: Rheumatology Associates of Oklahoma /ID# 228701
state: Oklahoma
city: Cranberry Township
country: United States
facility: Advanced Rheumatology & Arthritis Wellness Center /ID# 228608
state: Pennsylvania
city: Duncansville
country: United States
facility: Altoona Ctr Clinical Res /ID# 230058
state: Pennsylvania
city: Philadelphia
country: United States
facility: Arthritis Group /ID# 229777
state: Pennsylvania
city: Wyomissing
country: United States
facility: PA Regional Center for Arthritis and Osteoporosis Research /ID# 228742
state: Pennsylvania
city: Columbia
country: United States
facility: Columbia Arthritis Center /ID# 228705
state: South Carolina
city: Jackson
country: United States
facility: West Tennessee Research Institute /ID# 228257
state: Tennessee
city: Allen
country: United States
facility: Arthritis and Rheumatology Research Institute, PLLC /ID# 228937
state: Texas
city: Allen
country: United States
facility: Allen Arthritis /ID# 228712
state: Texas
city: Carrollton
country: United States
facility: Trinity Universal Research Associates - Carrollton /ID# 230104
state: Texas
city: Corpus Christi
country: United States
facility: Adriana Pop-Moody MD Clinic PA /ID# 230062
state: Texas
city: Lubbock
country: United States
facility: West Texas Clinical Research /ID# 228276
state: Texas
city: Lufkin
country: United States
facility: P&I Clinical Research /ID# 230183
state: Texas
city: Mesquite
country: United States
facility: SW Rheumatology Res. LLC /ID# 228088
state: Texas
city: Plano
country: United States
facility: Trinity Universal Research Associates, Inc /ID# 228238
state: Texas
city: Red Oak
country: United States
facility: Epic Medical Research /ID# 228097
state: Texas
city: San Antonio
country: United States
facility: Sun Research Institute /ID# 228768
state: Texas
city: The Woodlands
country: United States
facility: Advanced Rheumatology of Houston /ID# 228170
state: Texas
city: Tomball
country: United States
facility: DM Clinical Research - Tomball /ID# 228112
state: Texas
city: Tomball
country: United States
facility: Rheumatology Clinic of Houston /ID# 228178
state: Texas
city: Waco
country: United States
facility: Arthritis & Osteoporosis Clinic /ID# 228736
state: Texas
city: Newport News
country: United States
facility: Tidewater Physicians Medical Center /ID# 230130
state: Virginia
city: Spokane
country: United States
facility: Arthritis Northwest, PLLC /ID# 228275
state: Washington
city: Botany
country: Australia
facility: Emeritus Research Sydney /ID# 230070
state: New South Wales
city: Paramatta
country: Australia
facility: BJC Health /ID# 229015
state: New South Wales
city: Maroochydore
country: Australia
facility: Rheumatology Research Unit Sunshine Coast /ID# 229017
state: Queensland
city: Woodville South
country: Australia
facility: The Queen Elizabeth Hospital /ID# 230071
state: South Australia
city: Camberwell
country: Australia
facility: Emeritus Research /ID# 229018
state: Victoria
city: Edmonton
country: Canada
facility: Rheumatology Research Associates /ID# 227818
state: Alberta
city: Winnipeg
country: Canada
facility: Manitoba Clinic /ID# 227822
state: Manitoba
city: Sainte-foy
country: Canada
facility: Groupe de Recherche en Maladies Osseuses Inc /ID# 227821
state: Quebec
city: Trois-rivières
country: Canada
facility: Centre de Recherche Musculo-Squelettique /ID# 227824
state: Quebec
city: Saskatoon
country: Canada
facility: Dr Naik-Medical Professional Corporation-Alliance Health /ID# 227823
state: Saskatchewan
city: Praha
country: Czechia
facility: Revmatologicky ustav v Praze /ID# 229188
city: Praha
country: Czechia
facility: PV MEDICAL Services s.r.o. /ID# 228265
city: Praha
country: Czechia
facility: Revmatologicka ambulance - MUDr. Zuzana Urbanova /ID# 227775
city: Praha
country: Czechia
facility: Fakultni Nemocnice v Motole /ID# 231622
city: Uherske Hradiste
country: Czechia
facility: MEDICAL PLUS, s.r.o. /ID# 228030
city: Velke Bilovice
country: Czechia
facility: RHEUMA s.r.o. /ID# 230850
city: Herne
country: Germany
facility: Rheumazentrum Ruhrgebiet /ID# 227850
state: Nordrhein-Westfalen
city: Berlin
country: Germany
facility: Charite Universitaetsmedizin Berlin - Campus Mitte /ID# 229526
city: Hamburg
country: Germany
facility: MVZ Rheumatologie und Autoimmunmedizin Hamburg GmbH /ID# 227785
city: Athens
country: Greece
facility: General Hospital of Athens Gennimatas /ID# 227806
state: Attiki
city: Heraklion
country: Greece
facility: University General Hospital of Heraklion PA.G.N.I /ID# 227804
state: Kriti
city: Efkarpia (Thessalonikis)
country: Greece
facility: 424 General MILITARY Hospital /ID# 227805
state: Thessaloniki
city: Thessaloniki
country: Greece
facility: General Hospital of Thessaloniki Hippokrateio /ID# 229614
city: Debrecen
country: Hungary
facility: Debreceni Egyetem Klinikai Kozpont /ID# 228371
state: Hajdu-Bihar
city: Budapest
country: Hungary
facility: Obudai Egeszsegugyi Centrum Kft. /ID# 228359
state: Pest
city: Balatonfüred
country: Hungary
facility: DRC Gyogyszervizsgalo Kozpont Kft /ID# 228365
city: Budapest
country: Hungary
facility: Betegapolo Irgalmasrend Budai Irgalmasrendi Korhaz /ID# 227671
city: Budapest
country: Hungary
facility: Revita Reumatologiai Rendelo /ID# 227668
city: Szekesfehervar
country: Hungary
facility: CMED Rehabilitacios es Diagnosztikai Kozpont /ID# 227670
city: Veszprém
country: Hungary
facility: Vital Medical Center Orvosi es Fogaszati Kozpont (Vital Medicina Kft.) /ID# 227669
city: Zalaegerszeg
country: Hungary
facility: Obudai Egeszsegugyi Centrum Kft. Zalaegerszeg /ID# 228374
city: Haifa
country: Israel
facility: Rambam Health Care Campus /ID# 226798
state: H_efa
city: Haifa
country: Israel
facility: Bnai Zion Medical Center /ID# 226801
state: H_efa
city: Haifa
country: Israel
facility: The Lady Davis Carmel Medical Center /ID# 226802
state: H_efa
city: Kfar Saba
country: Israel
facility: Meir Medical Center /ID# 226800
state: HaMerkaz
city: Ramat Gan
country: Israel
facility: The Chaim Sheba Medical Center /ID# 226797
state: Tel-Aviv
city: Tel Aviv
country: Israel
facility: Tel Aviv Sourasky Medical Center /ID# 228341
state: Tel-Aviv
city: Rome
country: Italy
facility: Fondazione Policlinico Universitario Campus Bio-Medico di Roma /ID# 228917
state: Lazio
city: Ancona
country: Italy
facility: Azienda Ospedaliero Universitaria Ospedali Riuniti di Ancona /ID# 228581
city: Palermo
country: Italy
facility: Azienda Ospedaliera Universitaria Paolo Giaccone /ID# 228583
city: Nagoya-shi
country: Japan
facility: Japan Organization of Occupational Health and Safety Chubu Rosai Hospital /ID# 229899
state: Aichi
city: Nagoya-shi
country: Japan
facility: Daido Clinic /ID# 229280
state: Aichi
city: Fukui-shi
country: Japan
facility: Sugimoto rheumatology and internal medicine clinic /ID# 229495
state: Fukui
city: Fukuoka shi
country: Japan
facility: National Hospital Organization Kyushu Medical Center /ID# 228642
state: Fukuoka
city: Fukuoka-shi
country: Japan
facility: Hamanomachi Hospital /ID# 228644
state: Fukuoka
city: Fukuoka-shi
country: Japan
facility: Shono Rheumatism Clinic /ID# 229054
state: Fukuoka
city: Asahikawa-shi
country: Japan
facility: Katayama Orthopedic Rheumatology Clinic /ID# 229277
state: Hokkaido
city: Sapporo-shi
country: Japan
facility: Sagawa Akira Rheumatology Clin /ID# 228787
state: Hokkaido
city: Kato-shi
country: Japan
facility: Matsubara Mayflower Hospital /ID# 228948
state: Hyogo
city: Sanuki-shi
country: Japan
facility: Sanuki Municipal Hospital /ID# 229276
state: Kagawa
city: Kochi-shi
country: Japan
facility: Bay Side Misato Medical Center /ID# 228947
state: Kochi
city: Kumamoto shi
country: Japan
facility: Kumamoto Orthopaedic Hospital /ID# 228641
state: Kumamoto
city: Miyazaki-shi
country: Japan
facility: Medical Corporation Keiai Kai Clinic /ID# 228547
state: Miyazaki
city: Sasebo-shi
country: Japan
facility: Sasebo Chuo Hospital /ID# 229168
state: Nagasaki
city: Nagaoka-shi
country: Japan
facility: Nagaoka Red Cross Hospital /ID# 229962
state: Niigata
city: Kawachinagano Shi
country: Japan
facility: National Hospital Organization Osaka Minami Medical Center /ID# 229174
state: Osaka
city: Osaka-shi
country: Japan
facility: Osaka City General Hospital /ID# 228786
state: Osaka
city: Osaka-shi
country: Japan
facility: Japanese Red Cross Osaka Hospital /ID# 229816
state: Osaka
city: Sayama-shi
country: Japan
facility: Azuma Rheumatology Clinic /ID# 230078
state: Saitama
city: Chuo-ku
country: Japan
facility: St.Luke's International Hospital /ID# 229492
state: Tokyo
city: Meguro-ku
country: Japan
facility: National Hospital Organization Tokyo Medical Center /ID# 228720
state: Tokyo
city: Sumida-ku
country: Japan
facility: Medical Corporation Uchida Clinic /ID# 229494
state: Tokyo
city: Shimonoseki-shi
country: Japan
facility: Tokito Clinic Rheumatology and Orthopaedics Surgery /ID# 228354
state: Yamaguchi
city: Cheonan-si
country: Korea, Republic of
facility: SoonChunHyang University CheonAn Hospital /ID# 228146
state: Chungcheongnamdo
city: Seoul
country: Korea, Republic of
facility: Yonsei University Health System Severance Hospital /ID# 227659
state: Seoul Teugbyeolsi
city: Seoul
country: Korea, Republic of
facility: Hanyang University Seoul Hospital /ID# 227658
state: Seoul Teugbyeolsi
city: Daegu
country: Korea, Republic of
facility: Kyungpook National University Hospital /ID# 227657
city: Incheon
country: Korea, Republic of
facility: Inha University Hospital /ID# 227656
city: Seoul
country: Korea, Republic of
facility: Asan Medical Center /ID# 227655
city: Amsterdam
country: Netherlands
facility: Academisch Medisch Centrum /ID# 227234
city: Maastricht
country: Netherlands
facility: Maastricht Universitair Medisch Centrum /ID# 227235
city: Papatoetoe
country: New Zealand
facility: Aotearoa Clinical Trials /ID# 229012
state: Auckland
city: Timaru
country: New Zealand
facility: Timaru Medical Specialists Ltd /ID# 229013
state: Canterbury
city: Newtown
country: New Zealand
facility: Wellington Regional Hospital /ID# 233517
state: Wellington
city: Bydgoszcz
country: Poland
facility: Szpital Uniwersytecki nr 2 im. dr. Jana Biziela /ID# 227939
state: Kujawsko-pomorskie
city: Lodz
country: Poland
facility: AMICARE Sp. z o.o. sp.k. /ID# 231327
state: Lodzkie
city: Warszawa
country: Poland
facility: Centrum Medyczne Reuma Park /ID# 227170
state: Mazowieckie
city: Stalowa Wola
country: Poland
facility: SANUS Szpital Specjalistyczny /ID# 227171
state: Podkarpackie
city: Bialystok
country: Poland
facility: ClinicMed Daniluk, Nowak Sp.k. /ID# 227919
state: Podlaskie
city: Gdansk
country: Poland
facility: Centrum Badan Klinicznych PI-House sp. z o.o. /ID# 228047
state: Pomorskie
city: Warsaw
country: Poland
facility: MICS Centrum Medyczne Warszawa /ID# 231133
city: San Juan
country: Puerto Rico
facility: GCM Medical Group PSC /ID# 228981
city: San Juan
country: Puerto Rico
facility: Mindful Medical Research /ID# 228982
city: Moscow
country: Russian Federation
facility: Moscow Regional Research and Clinical Institute n.a. Vladimirskiy (MONIKI) /ID# 228755
state: Moskovskaya Oblast
city: Korolev
country: Russian Federation
facility: LLC Family Outpatient Clinic No /ID# 227926
state: Moskva
city: Yekaterinburg
country: Russian Federation
facility: Family Clinic /ID# 227929
state: Sverdlovskaya Oblast
city: Kazan
country: Russian Federation
facility: Kazan State Medical University /ID# 227927
state: Tatarstan, Respublika
city: Moscow
country: Russian Federation
facility: Central Clinical Hospital of Russian Academy of Science /ID# 229438
city: Pushkin
country: Russian Federation
facility: Euromedservice /ID# 227933
city: St. Petersburg
country: Russian Federation
facility: Clinical Rheumatologic Hospital No 25 /ID# 227922
city: Martin
country: Slovakia
facility: MEDMAN s.r.o. /ID# 227826
city: Nove Mesto nad Vahom
country: Slovakia
facility: Reum.hapi s.r.o. /ID# 227825
city: Piestany
country: Slovakia
facility: Thermium s.r.o. /ID# 227816
city: Poprad
country: Slovakia
facility: REUMAMED POPRAD s.r.o. /ID# 229628
city: Rimavska Sobota
country: Slovakia
facility: Reumex, s.r.o. /ID# 227827
city: Santiago de Compostela
country: Spain
facility: Hospital Clínico Universitario de Santiago-CHUS /ID# 227420
state: A Coruna
city: Sabadell
country: Spain
facility: Consorci Corporacio Sanitaria Parc Tauli Sabadell /ID# 227666
state: Barcelona
city: Bilbao
country: Spain
facility: Hospital Universitario Basurto /ID# 227667
state: Vizcaya
city: A Coruna
country: Spain
facility: Hospital Universitario A Coruna - CHUAC /ID# 227419
city: Madrid
country: Spain
facility: Hospital Universitario Fundacion Jimenez Diaz /ID# 234115
city: Madrid
country: Spain
facility: Hospital Universitario 12 de Octubre /ID# 227743
city: Malaga
country: Spain
facility: Hospital Regional Universitario de Malaga /ID# 227418
city: Sevilla
country: Spain
facility: Hospital Universitario Virgen de Valme /ID# 227417
city: Valencia
country: Spain
facility: Hospital Universitario y Politecnico La Fe /ID# 227408
city: Chia-Yi
country: Taiwan
facility: Dalin Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation /ID# 227220
city: New Taipei City
country: Taiwan
facility: Far Eastern Memorial Hospital /ID# 227373
city: Taipei City
country: Taiwan
facility: National Taiwan University Hospital /ID# 230001
city: Taipei
country: Taiwan
facility: Taipei Veterans General Hosp /ID# 227376
city: Sihhiye
country: Turkey
facility: Hacettepe Universitesi Tip Fak /ID# 227796
state: Ankara
city: Ankara
country: Turkey
facility: Ankara Univ Medical Faculty /ID# 227797
city: Kocaeli
country: Turkey
facility: Kocaeli University Med Faculty /ID# 228244
city: Kharkiv
country: Ukraine
facility: MNI City Multidisciplinary Hospital #18 Kharkiv City Council /ID# 228961
city: Khmelnytskyi
country: Ukraine
facility: Khmelnytskyi Regional Hospital /ID# 230680
city: Kyiv
country: Ukraine
facility: Medical Center of Medical Clinic Blagomed LLC /ID# 228956
city: Kyiv
country: Ukraine
facility: Medical Center "OK! Clinic+" LLC, "International Institute of Clinical Research" /ID# 228958
city: Kyiv
country: Ukraine
facility: Medical Center CONSILIUM MEDICAL /ID# 228959
city: Poltava
country: Ukraine
facility: PI "Poltava Regional Clinical Hospital n.a. M.V.Sklifosovsky of PCC" /ID# 228962
city: Vinnytsia
country: Ukraine
facility: CNE Vinnytsya Regional Clinical Hospital named after N.I.Pirogov /ID# 228954
city: Vinnytsia
country: Ukraine
facility: Сlinic Scientific Research Inst of Invalid Rehab ESMС M I Pyrogov VNMU /ID# 228955
Study officials:
affiliation: AbbVie
name: ABBVIE INC.
role: STUDY_DIRECTOR
References: