Clinical trial NCT06307717: Effects of Volatile Anaesthetics on Incidence of Postoperative Depression and Anxiety in Elderly Patients
Official title: Volatile Anaesthetics on Incidence of Postoperative Depression and Anxiety
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Cohort Studies
Keywords: Anxiety
Depression
Aged
Surgery
Volatile anaesthetics
Lead sponsor: Chinese PLA General Hospital
Sponsor class: OTHER
Collaborators: name: Beijing Tsinghua Changgeng Hospital
name: Peking University First Hospital
name: The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School
name: Xiangya Hospital of Central South University
name: Beijing Anzhen Hospital
name: Central South University
name: Peking University People's Hospital
name: Zhejiang University
name: Fudan University
name: Sun Yat-sen University
name: Wuhan Union Hospital, China
name: China-Japan Friendship Hospital
name: The Affiliated Hospital Of Guizhou Medical University
name: First Affiliated Hospital of Xinjiang Medical University
name: First Affiliated Hospital of Guangxi Medical University
name: Taihe Hospital
First posted: 2024-03-13
Enrollment: 8000
Sex: ALL
Minimum age (years): 65
Standard ages: OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: Elderly patients (aged ≥ 65 years) who completed the anxiety and depression assessment on the seventh day after the elective noncardiac, non-neurosurgical surgery were included in this study.

Brief summary: This study is a retrospective analysis of a large-scale multicentre prospective cohort study that investigates the impact of volatile anaesthetics on the incidence of postoperative depression and anxiety among elderly patients.

Detailed description: Studies have suggested volatile anaesthetics may alleviate depression and anxiety in patients. However, there is a paucity of research in this area. The investigatorswanted to determine the association between volatile anaesthetics and depression/anxiety in elderly patients within 7 days after surgery.

This study retrospectively analysed data from a prospective database of patients aged 65 and above who underwent non-cardiac, non-neurosurgical elective surgery in 18 tertiary hospitals across 10 provinces in China. Patients receiving volatile anaesthetics received at least one volatile anaesthetic (sevoflurane, isoflurane, desflurane), and those who received non-volatile anaesthetics did not receive any volatile anaesthetic. Binary logistic regression analyses were conducted, and propensity score-matching (PSM) and subgroup analyses were also applied.

Eligibility criteria: Inclusion Criteria:

Geriatric surgical patients ≥65 years old Non-selective cardiac surgery Non-neurosurgical

Exclusion Criteria:

1. underwent reoperation within 7 days
2. ASA classification of Ⅳ or above
3. history of serious mental illness or long-term use of psychotropic drugs
4. patients either died or were transferred to the intensive care unit within 7 days of the surgery
5. subjects with missing covariate data

Primary outcomes:
measure: Depression
timeFrame: Depression within 7 days of surgery
Secondary outcomes:
measure: Anxiety
timeFrame: Anxiety within 7 days of surgery
Other outcomes:
Locations:
city: Beijing
country: China
facility: Chinese PLA General Hospital
state: Beijing
Study officials:
affiliation: Chinese PLA General Hospital
name: WEIDONG MI, PhD
role: STUDY_CHAIR
References: