Clinical trial NCT05145036: The Effect of Tai Chi Exercise Among Elders With Sarcopenia
Official title: The Effect of Tai Chi Exercise Among Elders With Sarcopenia
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Sarcopenia in Elderly
Tai Chi
Lead sponsor: China Medical University Hospital
Sponsor class: OTHER
First posted: 2021-12-06
Enrollment: 60
Sex: ALL
Minimum age (years): 60
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: HEALTH_SERVICES_RESEARCH

Brief summary: Sarcopenia has been defined as a disease which presented as low muscles strength, low muscle quantity or quality and low physical activity. The prevalence of sarcopenia is increasing with the age and it is also included in one of geriatric syndromes. Several criteria have been mentioned for diagnosis of sarcopenia, such as European Working Group on Sarcopenia in Older People (EWGSOP)、Foundation for the National Institutes of Health Biomarkers Consortium Sarcopenia Project (FNIH) and Asian Working Group for Sarcopenia (AWGS).

In European, the prevalence rate of sarcopenia is 9.25-18%; 5-7% Canadian and 14.4% Taiwanese elders have been diagnosed as sarcopenia, respectively. The sarcopenia has been found its relationship with adverse outcomes of fall down, fracture, disability, and death. The cytokines and decline in anabolic hormones play a role in the pathogenesis of sarcopenia. Tai Chi exercise is one of Qigong and well-popular in Chinese population, and is helpful to integration of body movements. Tai Chi exercise is less complicated and emphasized people's awareness of self-care which presented the relationship between human and nature. Tai Chi exercise could improve muscle performance, balance and have the benefit for fall down prevention in the elders and patients with frailty. Furthermore, Tai Chi has been found that it also could improve the muscle power and power strength in sarcopenic elders by team training. Furthermore, immune makers of inflammation process have been noted their diminishments by Qigong intervention.

The aim of this study is to investigate the effect of Tai Chi exercise in sarcopenic elders through practicing at home. The differences of muscles strength, muscle quantity or quality and physical activity after interventions would be recorded and analyzed. The cytokines related to the sarcopenia process would also be sampled.


Eligibility criteria: Inclusion Criteria:

* Age 60 or older;
* With a diagnosis of sarcopenia \[defined as EWGSOP-2\] (6);
* Without planned exercise program or unplanned admission in 6 months;
* Could tolerate tests of muscle power and strength.

Exclusion Criteria:

* Uncontrolled diabetes mellitus;
* Uncontrolled cardiovascular diseases;
* Uncontrolled hypertension;
* Knee or hip prosthesis, pacemaker, fracture in the previous 6 months,
* Critical cognitive (MMSE\<23)
* Mini Nutritional Assessment (MNA \<17)
* Physical dysfunctions that could not tolerate our tests

Primary outcomes:
measure: Appendicular skeletal muscle mass in kilograms
timeFrame: baseline
measure: Change from baseline appendicular skeletal muscle mass at 8 weeks
timeFrame: 8 weeks
measure: Hand grip in kilograms
timeFrame: baseline
measure: Hand grip in kilograms
timeFrame: 8 weeks
measure: Times Chair-stand test (5-CST) in minutes
timeFrame: baseline
measure: Times Chair-stand test (5-CST) in minutes
timeFrame: 8 weeks
Secondary outcomes:
Other outcomes:
Locations:
city: Taichung
country: Taiwan
facility: China Medical University Hospital
Study officials:
affiliation: China Medicine University
name: China Medicine University China Medicine University
role: STUDY_CHAIR
References: