louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT06028958: Global Postural Re-Education And Neck Isometric Exercises In Cervical Radiculopathy RADICULOPATHY
Official title: Effects Of Global Postural Re-Education And Neck Isometric Exercises In Patients With Cervical Radiculopathy
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Cervical Radiculopathy
Lead sponsor: University of Lahore
Sponsor class: OTHER
First posted: 2023-09-08
Enrollment: 85
Sex: ALL
Minimum age (years): 18
Maximum age (years): 35
Standard ages: ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: Cervical radiculopathy is a common neurological disorder that is caused by compression of the nerve, inflammation of nerve roots, or space-occupying lesions. Cervical radiculopathy is the most common health-related problem worldwide. The conservative approach like education, specific exercises, and spinal manipulation is usually given for chronic cases with good outcomes.

Detailed description: Cervical Radiculopathy is a condition in which a nerve is entrapped between the bones and causes numbness and tingling. Neck isometric exercises are a basic treatment plan for strength training. Global postural reeducation is a technique the manual cervical traction along with body alignment that helps to reduce symptoms more rapidly. This whole procedure is completed more easily, without a machine and satisfying for the patient.

Eligibility criteria: Inclusion Criteria:

1. 18 to 35 years.
2. Both genders, Males and females
3. One-sided upper limb pain or numbness
4. Any 2 out of 4 tests are positive Spurling test, Distraction test, Ipsilateral cervical traction test, and Upper Limb test

Exclusion Criteria:

1. Bilateral upper limb pain
2. Previous history of cervical surgery
3. Cervical spine
4. Injection therapy in the past 2 weeks
5. Being Pregnant women

Primary outcomes:
measure: Pain Intensity
timeFrame: Pain intensity will be measured at baseline, and change in pain intensity will be measured at 1st week, and 2nd week of treatment..
measure: Level of Functional Disability
timeFrame: Change in Functional Status will be measured at baseline, at first week, and at second week of treatment.
Secondary outcomes:
Other outcomes:
Locations:
city: Lahore
country: Pakistan
facility: The University of Lahore
state: Punjab
Study officials:
affiliation: The University of Lahore
name: Ashfaq Dr Ahmed, PhD
role: STUDY_CHAIR
References:
Clinical trial NCT03040258: Interventions to Promote Healthy Eating and Physical Activity in Lebanese School Children Targeting Overweight and Obesity- Pilot Study
Official title: Interventions to Promote Healthy Eating and Physical Activity in Lebanese School Children Targeting Overweight and Obesity-Pilot Study
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Childhood Obesity
Keywords: School-based intervention
Lead sponsor: American University of Beirut Medical Center
Sponsor class: OTHER
First posted: 2017-02-02
Enrollment: 374
Sex: ALL
Minimum age (years): 9
Maximum age (years): 11
Standard ages: CHILD
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: PREVENTION

Brief summary: Evaluate the feasibility and effectiveness of a multi-component school-based intervention to promote healthy eating and physical activity with school children ages 9 to 11 years in Lebanon.


Eligibility criteria: Inclusion Criteria:

* Schoolchildren
* Aged 9 to 11 years

Exclusion Criteria:

- no exclusion criteria

Primary outcomes:
measure: Change in knowledge score
timeFrame: One school year
measure: Change in dietary habits
timeFrame: One school year
measure: Change in self-efficacy score
timeFrame: One school year
Secondary outcomes:
measure: Change in body weight status
timeFrame: One school year
Other outcomes:
Locations:
Study officials:
affiliation: American University of Beirut Medical Center
name: Nahla Houalla, PhD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT04608058: Promoting Self-management Behaviors in Adolescents With Type 1 Diabetes, Using Digital Storytelling
Official title: Comparison of Self-management Behaviors Education Through Digital Storytelling Method and Conventional Method in Adolescents With Type 1 Diabetes Referred to Diabetes Clinic in Hospitals Affiliated to Shiraz University of Medical Sciences.
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Diabetes Mellitus, Type 1
Self-Management
Lead sponsor: Shiraz University of Medical Sciences
Sponsor class: OTHER
First posted: 2020-10-29
Enrollment: 60
Sex: ALL
Minimum age (years): 12
Maximum age (years): 18
Standard ages: CHILD
ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: SUPPORTIVE_CARE

Brief summary: The aim of this study was to evaluate the effects of digital storytelling on the Self-Management behavior of adolescents with type 1 diabetes (TID).

Detailed description: In this single-blind randomized controlled trial, 60 eligible adolescents with TID were selected based on a convenient sampling method. Next, the participants were randomly allocated into two parallel groups: intervention (training with digital storytelling method, n=30) or control (training with conventional) n=30) groups. Before and three months after the intervention the patients' levels of self-management behaviors according to Self-Management of TID amongst adolescents (SMOD-A); in addition to the Glycated Hemoglobin test (HbA1c) were measured.

Eligibility criteria: Inclusion Criteria:

* adolescents with TID
* using medication (insulin)
* willing to participate in the study and complete the informed consent
* having a basic knowledge of working with computers
* ability to communicate on the telephone.

Exclusion Criteria:

* physical or mental disabilities
* take anti-anxiety or antidepressant medication

Primary outcomes:
measure: Change in Self-management behavior
timeFrame: 3 months
Secondary outcomes:
measure: Change in Glycated hemoglobin A1c
timeFrame: 3 months
Other outcomes:
Locations:
city: Shiraz
country: Iran, Islamic Republic of
facility: Shiraz University of Medical Sciences
state: Fars
Study officials:
affiliation: associate Professor, Virtual school, Shiraz University of Medical Sciences, Shiraz, Iran.
name: Nahid zarifsanaiey
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT06880458: To Validate Changes in Knowledge, Attitudes and Practices (KAPs) Related to the Know Your OQ Initiative and to Understand the Readability, Comprehension and Ease of Use of the Know Your OQ Quiz
Official title: Evaluation of Short-term Changes and Self-reported User Experiences Related to the Know Your OQ™ Initiative
Study type: OBSERVATIONAL
Overall status: ACTIVE_NOT_RECRUITING
Conditions: Literacy-language Intervention
Keywords: attitudes
knowledge
oral care
Lead sponsor: Colgate Palmolive
Sponsor class: INDUSTRY
First posted: 2025-03-17
Enrollment: 100
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: OTHER
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: Nurses attending NAHN conference

Brief summary: To validate changes in knowledge, attitudes and practices (KAPs) related to the KnowYour OQ initiative and to understand the readability, comprehension and ease of use of the Know Your OQ quiz

Detailed description: Quantitative analysis will be carried out for changes in knowledge, attitudes and practices(KAPs) after the exposure to the Know Your OQ™ intervention. Qualitative and quantitative analysis will becarried out for readability, comprehension and ease of use of the Know Your OQ™ quiz.

Eligibility criteria: Inclusion Criteria:

* Signed Informed Consent Form.
* Male and female subjects aged 18-65+ years old
* Availability for the duration of the study
* English or Spanish fluency
* Access to laptop, tablet or computer with internet/data connection

Exclusion Criteria:

* Not present at NAHn Convention

Primary outcomes:
measure: Knowledge, attitudes and practices towards oral health questionnaire intervention
timeFrame: 1 year
Secondary outcomes:
measure: Qualitative Interviews
timeFrame: 1 year
Other outcomes:
Locations:
city: Lexington
country: United States
facility: National Association of Hispanic Nurses
state: Kentucky
Study officials:
References:
Clinical trial NCT06834958: Clinical Diagnosis of Acute Appendicitis with Normal WBCS Count with Role of Inflammatory Markers and Radiology
Official title: Clinical Diagnosis of Acute Appendicitis with Normal WBCS Count with Role of Inflammatory Markers and Radiology
Study type: OBSERVATIONAL
Overall status: ACTIVE_NOT_RECRUITING
Conditions: Acute Appendicitis
Keywords: Clinical diagnosis of acute appendicitis
Lead sponsor: Assiut University
Sponsor class: OTHER
First posted: 2025-02-19
Enrollment: 50
Sex: ALL
Minimum age (years): 14
Maximum age (years): 60
Standard ages: CHILD
Accepts healthy volunteers: yes
Observational model: CASE_ONLY
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Study not need special type of people

Brief summary: The aim of this study is to describe the proportion of pa-tients with normal preoperative inflammatorymarkers among patients with histopathologically proven acute appendicitis

Detailed description: 2.4.1- Type of the study: prospective clinical trial study 2.4. 2- Study Setting: Assuit university hospital 2.4. 3- Study subjects:

1. Inclusion criteria:

   patients complain of Rt iliac pain with Us positive for acute appendicitis with WBCS normal .
2. Exclusion criteria:

malignant mass cancer appendix mesenteric adentis cecal diverticulum salpingitis c. Sample Size Calculation: 50 cases 2.4.4 -Study tools (in detail, e.g., lab methods, instruments, steps, chemicals, ...): Lab WBCS count CRP level Neutrophil differential count Clinical correlation US findings and MSCT if needed

Eligibility criteria: Inclusion

* Male or female patients é clinically diagnosed acute appendicitis with normal WBCS

Exclusion Criteria:

* complicated AA (perforation, peri appendicular abscess or suspicion of a tumor.

  2_inflammatory bowel diseases 3_inability to co-operate and give informed consent 4_diffuse peritonitis 5_Patients with serious comorbid conditions DM \& renal insufficiency, serum creatinine \> 150 μmol/l 6_Pregnant \& lactating patient 7_Patients with advanced malignancies \& pt on immunosuppressive drugs

Primary outcomes:
measure: Surgery done if needed
timeFrame: Days of hospital reservation
Secondary outcomes:
Other outcomes:
Locations:
city: Assuit
country: Egypt
facility: Assuit university
Study officials:
References:
Clinical trial NCT01369758: MyoSure Hysteroscopic Tissue Removal System Registry Study
Official title: MyoSure Hysteroscopic Tissue Removal System Registry Study
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Uterine Fibroids
Polyps
Keywords: morcellator
hysteroscope
myomectomy
polypectomy
uterine fibroids
uterine polyps
Lead sponsor: Hologic, Inc.
Sponsor class: INDUSTRY
First posted: 2011-06-09
Enrollment: 290
Sex: FEMALE
Minimum age (years): 18
Maximum age (years): 65
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: TREATMENT

Brief summary: The objective of this study is to demonstrate the safety and effectiveness of community gynecologist initiated treatment of intra-uterine polyps and submucosal fibroids with the MyoSure Hysteroscopic Tissue Removal System in a significantly sized patient population.

Detailed description: Between 500 and 600 subjects will be enrolled in a prospective, multi-center registry study. Approximately 100 of these cases will be completed in an office setting, with the remaining 400-500 cases completed in a hospital outpatient or ambulatory surgery center. Subjects will undergo a hysteroscopic tissue removal procedure to remove intrauterine polyps and submucosal fibroids.

Eligibility criteria: Inclusion Criteria:

1. Healthy female between 18 and 65 years of age
2. Subject must be able to understand, read and sign the study specific informed consent forms after the nature of the study has been fully explained to her
3. Subject is indicated for myomectomy or polypectomy
4. Subject exhibits intrauterine polyps and/or submucous myomas which meet one of the following criteria. In cases of subjects with multiple intrauterine pathology, classification is based as follows:

   * All polyps
   * All Type 0, Type 1 or Type 2 myomas ≤ 6 cm in diameter
   * Polyps plus Type 0, Type 1 or Type 2 myomas ≤6 cm in diameter

Exclusion Criteria:

1. Subject is pregnant
2. Subject has an Intrauterine Device (IUD) at the time of the procedure. A subject may be enrolled in the study if the IUD is removed prior to the treatment procedure
3. Subject is taking an anticoagulant or antiplatelet medication other than low dose aspirin
4. Active pelvic inflammatory disease or pelvic/vaginal infection
5. Subject has a known or suspected coagulopathy or bleeding disorder
6. Subject has a history of disease which increases the risk for fluid overload (i.e. significant cardiac, hepatic, or renal dysfunction)
7. Subject has other co-morbid condition(s) that, in the opinion of the Investigator, could limit the subject's ability to participate in the study or impact the scientific integrity of the study

Primary outcomes:
measure: Procedure Efficacy
timeFrame: 1 hour post treatment
Secondary outcomes:
measure: Percentage of Subjects That Achieve 100% Removal of Target Pathology
timeFrame: 1 hour post treatment
Other outcomes:
Locations:
city: Marlborough
country: United States
facility: Hologic, Inc.
state: Massachusetts
Study officials:
affiliation: Hologic, Inc.
name: Edward Evantash
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT04816058: Turkish Version of the Ankle Instability Instrument
Official title: Reliability and Validity of the Turkish Version of the Ankle Instability Instrument
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Ankle Injuries
Lead sponsor: Acibadem University
Sponsor class: OTHER
First posted: 2021-03-25
Enrollment: 180
Sex: ALL
Minimum age (years): 18
Maximum age (years): 40
Standard ages: ADULT
Accepts healthy volunteers: yes
Observational model: CASE_CONTROL
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Participants with a history of ankle injury and healthy population.

Brief summary: This study aimed to translate the Ankle Instability Instrument into Turkish language, to perform a cultural adaptation study and to evaluate its validity and reliability in the Turkish population. Ankle Instability Instrument was developed to determine the ankle instability level of individuals with a history of ankle injury. Assessment of ankle instability is particularly useful in determining the complaints and functional levels of individuals with a history of functional or chronic ankle instability. It is anticipated that introducing this scale to our language will contribute to other studies in this field.


Eligibility criteria: Inclusion Criteria:

* History of ankle injury or sprain at least one time
* Aged between 18 to 40 years

Exclusion Criteria:

* Neurological or orthopedic disorders that may affect ankle instability.

Inclusion criteria for healthy population are; no history of ankle injury or sprain before and. aged between 18 to 40 years

Primary outcomes:
measure: Ankle Instability Instrument
timeFrame: 2 weeks
measure: Cumberland Ankle Instability Tool
timeFrame: 1 day
Secondary outcomes:
measure: Short Form 12
timeFrame: 1 day
Other outcomes:
Locations:
city: Istanbul
country: Turkey
facility: Acıbadem University
Study officials:
References:
Clinical trial NCT00584558: Long-Term Follow-Up of Patients Undergoing Catheter Ablation
Official title: Long-Term Follow-Up of Catheter Ablation
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Arrhythmia
Keywords: Arrhythmia
Catheter Ablation
Lead sponsor: University of Oklahoma
Sponsor class: OTHER
First posted: 2008-01-02
Enrollment: 2420
Sex: ALL
Minimum age (years): 1
Maximum age (years): 100
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Patients undergoing catheter ablation at the OU Medical Center

Brief summary: The purpose of this study is to assess the long-term effects of catheter ablation procedures performed at the OU Medical Center.

Detailed description: The purpose of this study is to assess the long-term effects of catheter ablation procedures performed at this institution, including recurrence of the ablated arrhythmia and any late complications.

Eligibility criteria: Inclusion Criteria:

* Undergoing catheter ablation at the OU Medical Center

Exclusion Criteria:

* Prisoners
* Refusal to participate

Primary outcomes:
measure: Number of Patients With Arrhythmia Recurrence
timeFrame: 0-10 years
Secondary outcomes:
measure: Number of Patients With Complications From Catheter Ablation
timeFrame: 0-10 years
Other outcomes:
Locations:
city: Oklahoma City
country: United States
facility: OU Medical Center
state: Oklahoma
Study officials:
affiliation: University of Oklahoma
name: Karen Beckman, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT02676258: Clinical Comparison of Two Daily Disposable Silicone Hydrogel Soft Contact Lens
Official title: A Prospective Randomized Controlled Study to Evaluate the Clinical Performance of Si-Hy Silicone Hydrogel Soft Contact Lens
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Myopia
Keywords: silicone hydrogel daily disposable soft contact lens
Lead sponsor: Visco Vision Inc.
Sponsor class: INDUSTRY
First posted: 2016-02-08
Enrollment: 60
Sex: ALL
Minimum age (years): 20
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: SUPPORTIVE_CARE

Brief summary: The objective of this study is to evaluate a new daily disposable silicone hydrogel soft contact lens by comparing to an existing daily disposable soft contact lens.

Detailed description: This study is designed to evaluate the performance of the olifilcon B contact lens to demonstrate substantial equivalence to the narafilcon A for regulatory requirement.

Eligibility criteria: Inclusion Criteria:

* Subject should have normal eyes and use no ocular medications
* Subject with -1.00 to -10.00 D myopia, less than 2.00 D astigmatism
* VA correctable to Log MAR 0.1 or better.
* Willing to comply with all study procedures and be available for the duration of the study.
* Provide signed and dated informed consent form.

Exclusion Criteria:

* Subjects have history of allergies that would contraindicate "normal" contact lens wear.
* Subjects have other active ocular or systemic disease such as, but not limited to : anterior uveitis (past or present), glaucoma, Sjögren's syndrome, lupus erythematosus, sclerodermas, keratoconus or type II diabetes.
* Subjects have medications that would contraindicate contact lens wear.
* Currently pregnant (to the best of the subject's knowledge), is lactating or is planning a pregnancy within the next 3 month.
* Current drug or alcohol use or dependence that, in the opinion of the site investigator, would interfere with adherence to study requirements.
* Any active participation in another clinical trial within 30 days prior to this study.
* The presence of clinically significant (grade 3 or 4) anterior segment abnormalities; inflammations such as iritis; or any infection of the eye, lids, or associated structures.
* A known history of corneal hypoesthesia (reduced corneal sensitivity), corneal ulcer, corneal infiltrates or fungal infections.
* A history of papillary conjunctivitis that has interfered with contact lens wear.

Primary outcomes:
measure: Visual Acuity
timeFrame: over all follow-up visits for 3 month study period
Secondary outcomes:
measure: Any Slit Lamp Finding > Grade 2
timeFrame: over all follow-up visits for the 3 month study period
measure: Subjective Response to Comfort, symptoms and complaints
timeFrame: over all follow-up visits for the 3 month study period
Other outcomes:
Locations:
city: Taipei
country: Taiwan
facility: MayKay Memorial Hospital
Study officials:
affiliation: Mackay Memorial Hospital
name: Huey Chuan Cheng, MD MS
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT00624858: A Study of Naltrexone SR/ Bupropion SR in Overweight or Obese Subjects With Major Depression
Official title: An Open-Label Study Assessing the Safety and Efficacy of Naltrexone Sustained Release (SR)/Bupropion Sustained Release (SR) in Overweight or Obese Subjects With Major Depression
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE2
Conditions: Depression
Keywords: Depression
depressed
overweight
obese
Lead sponsor: Orexigen Therapeutics, Inc
Sponsor class: INDUSTRY
First posted: 2008-02-27
Enrollment: 25
Sex: ALL
Minimum age (years): 18
Maximum age (years): 65
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: TREATMENT

Brief summary: The purpose of this study is to determine whether a combination of naltrexone SR and bupropion SR is safe and effective in the treatment of major depression in overweight or obese subjects.


Eligibility criteria: Inclusion Criteria:

* Female and male subjects must be 18 to 65 years of age;
* Have body mass index (BMI) greater or equal to 27 and less than or to equal 43kg/m2;
* Meet criteria for major depression
* Women of child-bearing potential, must be non-lactating and agree to use effective contraception throughout the study period and 30 days after discontinuation of study drug;
* Able to comply with all required study procedures and schedule;
* Able to speak and read English;
* Willing and able to give written informed consent

Exclusion Criteria:

* Obesity of known endocrine origin
* Serious medical condition
* History of drug or alcohol abuse or dependence
* Use of excluded concomitant medications
* History of surgical or device (e.g. gastric banding) intervention for obesity;
* History or predisposition to seizures
* Pregnant or breast-feeding women or planning to become pregnant during the study period or within 30 days of discontinuing study drug;
* Planned surgical procedure that can impact the conduct of the study;
* Use of investigational drug, device or procedure within 30 days prior to Screening;
* Participation in any previous clinical trial conducted by Orexigen Therapeutics;
* Any condition which in the opinion of the investigator makes the subject unsuitable for inclusion in the study.

Primary outcomes:
measure: To assess the change in depressive symptoms as measured by Montgomery-Asberg Depression Rating Scale (MADRS) total score at 12 weeks
timeFrame: 12 Weeks
Secondary outcomes:
measure: To assess the percentage change from baseline in total body weight at 12 and 24 weeks.
timeFrame: 12 and 24 weeks
Other outcomes:
Locations:
city: Mason
country: United States
facility: Lindner Center of HOPE
state: Ohio
Study officials:
affiliation: University of Cincinnati
name: Susan McElroy, MD
role: PRINCIPAL_INVESTIGATOR
References:
citation: McElroy SL, Guerdjikova AI, Kim DD, Burns C, Harris-Collazo R, Landbloom R, Dunayevich E. Naltrexone/Bupropion combination therapy in overweight or obese patients with major depressive disorder: results of a pilot study. Prim Care Companion CNS Disord. 2013;15(3):PCC.12m01494. doi: 10.4088/PCC.12m01494. Epub 2013 Jun 20.