Clinical trial NCT02784041: Single Adductor-canal-block Versus Peri-articular Infiltration on Outcome After Total Knee Arthroplasty
Official title: Comparison of the Effect of Single Adductor-canal-block and Peri-articular Infiltration on the Outcome After Unilateral Total Knee Arthroplasty
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Osteoarthritis,Knee
Keywords: knee arthroplasty
adductor canal block
periarticular infiltration
Lead sponsor: Peking Union Medical College Hospital
Sponsor class: OTHER
First posted: 2016-05-26
Enrollment: 200
Sex: ALL
Minimum age (years): 45
Maximum age (years): 85
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The purpose of this study is to compare the effect of single adductor-canal-block versus single femoral nerve block on the recovery after total knee arthroplasty.

Detailed description: The aim of this study is to assess the effect of different analgesic effects on the outcome of patients undergoing total knee arthroplasty. Patients who will have primary unilateral total knee replacement between September 2016 to June 2018 at Peking Union Medical College Hospital and meet the inclusion criteria will be included. They are randomized into two groups. The total knee arthroplasty is performed by one surgeon and adductor-canal block is performed by one anesthesiologist who is not responsible for follow-up. Patients on both groups will have intravenous patient control analgesia with 1 mg morphine/bolus. One residency is responsible for the follow-up.

Eligibility criteria: Inclusion Criteria:

* osteoarthritis
* unilateral total knee arthroplasty
* ASA grade I - II
* normal cognitive function.

Exclusion Criteria:

* patients refuse
* BMI \> 35
* diagnosis other than osteoarthritis
* allergy to the drugs used or contraindication to the intervention

Primary outcomes:
measure: the time required for functional recovery
timeFrame: from the date of the surgery to the time when the patients meet the criteria of functional recovery. The earliest day on which the patient achieves the criteria of functional recovery will be recorded and the average time is 7 days after surgery.
Secondary outcomes:
measure: postoperative WOMAC scales
timeFrame: pre-operative, three months,six months and one year afer the surgery
measure: Postoperative complications
timeFrame: daily after the surgery until discharge from hospital, expected average up to 5 days after the surgery
measure: postoperative VAS scale
timeFrame: pre-operative, 6h postoperative, 24h postoperative, 48h postoperative, one month postoperative, three-month postoperative, one year postoperative
measure: postoperative morphine consumption
timeFrame: 6h, 24h, 48h after the surgery
measure: postoperative SF-36 score
timeFrame: pre-operative, three months,six months and one year afer the surgery
Other outcomes:
measure: patients' satisfaction
timeFrame: before discharge, usually 3-4 days after the surgery and one year after the surgery
Locations:
city: Beijing
country: China
facility: Peking Union Medical College Hospital
Study officials:
affiliation: Peking Union Medical College Hospital
name: Yuguang Huang, Dr
role: STUDY_CHAIR
References: