louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT05189119: Use of PARniv for Early Diagnosis of LVF in AECOPD
Official title: Study of Pressure Support Under Non-invasive Ventilation in the Early Diagnosis of Left Ventricular Failure During Acute Exaverbation of Chronic Obstructive Pulmonary Disease
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Acute Heart Failure
COPD Exacerbation
Keywords: COPD
Left Ventricular Failure
Pressure Support under NIV
Lead sponsor: University of Monastir
Sponsor class: OTHER
First posted: 2022-01-12
Enrollment: 80
Sex: ALL
Minimum age (years): 18
Maximum age (years): 80
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: all patients presenting to the ED with an acute COPD exacerbation

Brief summary: Left ventricular failure (LVF) is a common cause of acute exacerbation of chronic obstructive pulmonary disease (AECOPD).

This association is frequently underestimated with regard to the difficulty of clinical diagnosis .

The investigators expect that the application of pressure support under NIV could be useful in this issue.

Detailed description: Acute heart failure (AHF) is a common cause of COPD exacerbation however its role is very often underestimated. Until now, the use of echocardiography and some invasive hemodynamic exploration techniques such as the Swan-ganz catheter has been stated as reference. Other noninvasive diagnostic methods have been studied, such as systolic time intervals and Valsalva maneuver, but their application still difficult in patients with COPD exacerbation, especially in emergency department (ED) settings. the study aimed to evaluate the performance of a new diagnostic technique based on the measurement of the PAR using non invasive ventilation (NIV) for the early identification of left ventricular failure (LVF) in patients presenting to the ED with acute COPD exacerbation

Eligibility criteria: Inclusion Criteria:

* patients with a history of COPD
* consulted the emergency department for AECOPD defined by a respiratory rate \>25c/min, SaO2 \<90%, pH \<7.35 and PaCO2 \>6kPa were included.

Exclusion Criteria:

* hemodynamic instability requiring the use of vasoactive drugs
* patients with contraindications to NIV (Glasgow score \<12, swallowing disorder or severe bronchial obstruction, vomiting, and those with upper airway obstruction or ongoing upper gastrointestinal bleeding and altered bronchial clearance)
* non cooperative patients
* who refused to give consent.

Primary outcomes:
measure: left ventricular dysfunction
timeFrame: 24 hours
Secondary outcomes:
Other outcomes:
Locations:
city: Monastir
country: Tunisia
facility: University hospital of Monastir
Study officials:
References:
Clinical trial NCT06695819: Evaluation of Nail Technicians With Quick Exposure Check
Official title: Ergonomic Evaluation of Nail Technicians With Quick Exposure Check
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Postural; Strain
Lead sponsor: Istanbul Physical Medicine Rehabilitation Training and Research Hospital
Sponsor class: OTHER_GOV
First posted: 2024-11-19
Enrollment: 35
Sex: FEMALE
Minimum age (years): 18
Maximum age (years): 40
Standard ages: ADULT
Observational model: CASE_ONLY
Time perspective: CROSS_SECTIONAL
Sampling method: PROBABILITY_SAMPLE
Study population: The study population consisted of 35 female nail technicians aged between 18 and 40 years, working in 14 manicure salons located across four districts (Bahçelievler, Küçükçekmece, Beylikdüzü, and Esenyurt) on the European side of Istanbul. All participants were actively employed as nail technicians for at least six months and volunteered to participate in the study.

Brief summary: This cross-sectional study evaluated the ergonomic risks and occupational symptoms among 35 female nail technicians using the Quick Exposure Check (QEC) and the Extended Nordic Musculoskeletal Questionnaire (NMQ-E).

Detailed description: This clinical cross-sectional study assessed 35 female nail technicians from 14 salons in four districts on the European side of Istanbul (Bahçelievler, Küçükçekmece, Beylikdüzü, and Esenyurt). Data collection included interviews, questionnaires, and ergonomic evaluations. The European Community Respiratory Health Survey and the Extended Nordic Musculoskeletal Questionnaire (NMQ-E) were used to assess symptoms, while ergonomic risks were evaluated using the Quick Exposure Check (QEC) by trained physiatrists. Following the assessments, technicians received ergonomic training on posture correction and risk prevention.

Eligibility criteria: Inclusion Criteria:

* Female nail technicians aged 18-40 years.
* Actively working as a nail technician for at least six months.
* Willingness to voluntarily participate in the study.

Exclusion Criteria:

* Pre-existing musculoskeletal disease diagnosis.
* Rheumatic or neurological diseases.
* Central sensitization syndromes (e.g., fibromyalgia, chronic fatigue syndrome).
* Psychiatric illnesses or mental disorders impeding communication.

Primary outcomes:
measure: Quick Exposure Check (QEC)
timeFrame: 0 day
Secondary outcomes:
measure: Extended Nordic Musculoskeletal Questionnaire (NMQ-E)
timeFrame: 0 day
Other outcomes:
Locations:
city: Istanbul
country: Turkey
facility: Istanbul Physical Medicine Rehabilitation Training and Research Hospital
Study officials:
References:
Clinical trial NCT02148341: Implementation of the Hospital to Home (H2H) Heart Failure Initiative
Official title: Implementation of the Hospital to Home (H2H) Heart Failure Initiative
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Heart Failure
Lead sponsor: VA Palo Alto Health Care System
Sponsor class: FED
First posted: 2014-05-28
Enrollment: 122
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: HEALTH_SERVICES_RESEARCH

Brief summary: This study determines if a community of practice of clinicians and quality improvement specialists can be used to implement a national quality initiative known as Hospital to Home (H2H). This quality initative is designed to reduced readmission rates for patients with heart failure or heart attack by improving the transition of care upon discharge.


Eligibility criteria: Inclusion Criteria:

* VA medical centers are the unit of randomization. A medical center will be included if had at least 20 patients discharged with a principal diagnosis of heart failure in 2008

Primary outcomes:
measure: H2H enrollment
timeFrame: 6 months
Secondary outcomes:
measure: quality improvement programs initiated due to H2H
timeFrame: 6 months
Other outcomes:
Locations:
city: Palo Alto
country: United States
facility: VA Palo Alto Health Care System
state: California
Study officials:
References:
Clinical trial NCT06326541: The Effect of Listening to the Holy Quran on Vital Signs in Coma Patients
Official title: The Effect of Listening to the Holy Quran on Life Findings in Coma Patients Hospitalized in Surgical Intensive Care Unit
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Sequelae of; Complications Surgical and Medical Care
Lead sponsor: Bitlis Eren University
Sponsor class: OTHER
First posted: 2024-03-22
Enrollment: 72
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Intervention model description: single group pretest-posttest
Primary purpose: SUPPORTIVE_CARE

Brief summary: The aim of this study is to examine the effect of the Holy Quran listened to to coma patients on their vital signs.

Does listening to the Holy Quran have a positive effect on the life values of coma patients?

Detailed description: This study aims to examine the effect of listening to the Holy Quran on vital signs (fever, pulse, respiration, systolic-diastolic blood pressure, saturation) in surgical intensive care unit patients. The unique value of this study, unlike other studies, is to examine the positive changes in patients' vital signs by listening to the Holy Quran (Surah Rahman) instead of classical music.

Eligibility criteria: Inclusion Criteria:

* Being over 18 years of age
* Being a surgical intensive care patient
* Having a Glasgow coma score of 8 points or less

Exclusion Criteria:

* The patient must be under 18 years of age
* Have a Glaskow coma score above 8 points
* Be out of coma during the time the research continues

Primary outcomes:
measure: systolic blood pressure- (mmHg)
timeFrame: 30 minutes
measure: diastolic blood pressure- (mmHg)
timeFrame: 30 minutes
measure: pulse (number of beats/min)
timeFrame: 30 minutes
measure: body temperature (degrees Celsius)
timeFrame: 30 minutes
measure: saturation (%-oxygen saturation)
timeFrame: 30 minutes
Secondary outcomes:
Other outcomes:
Locations:
city: Bitlis
country: Turkey
facility: Bitlis Eren University
Study officials:
affiliation: Bitlis Eren University
name: Şerafettin OKUTAN, Dr.
role: PRINCIPAL_INVESTIGATOR
References:
citation: Yorke J, Wallis M, McLean B. Patients' perceptions of pain management after cardiac surgery in an Australian critical care unit. Heart Lung. 2004 Jan-Feb;33(1):33-41. doi: 10.1016/j.hrtlng.2003.09.002.
Clinical trial NCT02647541: Preoperative Nutritional Intervention and Outcomes of Children Submitted to Heart Surgery for Congenital Heart Diseases
Official title: Preoperative Nutritional Intervention and Outcomes Postoperative of Children Submitted to Heart Surgery for Congenital Heart Diseases
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Congenital Heart Disease
Malnutrition
Keywords: Children
Congenital heart disease
Nutritional status
Bioelectrical impedance
Lead sponsor: University of Sao Paulo
Sponsor class: OTHER
First posted: 2016-01-06
Enrollment: 11
Sex: ALL
Minimum age (years): 30
Maximum age (years): 5
Standard ages: CHILD
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: SUPPORTIVE_CARE

Brief summary: The hypothesis of this study is a nutrition preoperatively in infants and children undergoing elective cardiac surgery with cardiopulmonary bypass leads to improvement in nutritional status, intervention, and that this results in good postoperative results.

Detailed description: If this hypothesis is confirmed, there will be subsidies for systematic implementation of nutritional interventions in patients seen in service.

Eligibility criteria: Inclusion Criteria:

* Patient with congenital heart disease requiring elective surgical correction;
* Age\> 30 days and ≤ 5 years, with the aim of excluding the neonatal period, which are operated children with complex heart defects, and older children, where the time living with the disease damages the myocardium and the pulmonary circulation, leaving only children with fewer serious and, in general, are less subjected to complex surgery diseases.

Exclusion Criteria:

* Chronic gastrointestinal diseases (defects, malabsorption, celiac disease, inflammatory bowel disease, diabetes mellitus);
* Patients with other organic defects that may compromise the growth and / or nutritional status;
* Patients undergoing emergency surgery;
* Request of parents or guardians at any time;
* Patients receiving exclusive breastfeeding;
* Died during the study period;
* Patients using cardiac pacemaker or other electrical or electronic device that interferes with the reading of the electrical bioimpedance.

Primary outcomes:
measure: Nutritional status
timeFrame: 30 to 45 days prior to surgery
Secondary outcomes:
measure: Surgical outcomes
timeFrame: on average 15 days after surgery
Other outcomes:
Locations:
city: Ribeirão Preto
country: Brazil
facility: Faculty of Medicine of Ribeirão Preto / USP
state: São Paulo
Study officials:
affiliation: FMRP/USP
name: Thatiane D Santos, Msc
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT02565641: A Study of Capecitabine (Xeloda) in Participants With Locally Advanced or Metastatic Pancreatic Cancer
Official title: An Open-label, Phase II Study of Capecitabine Plus Gemcitabine in Patients With Locally Advanced or Metastatic Pancreatic Cancer
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE2
Conditions: Pancreatic Cancer
Lead sponsor: Hoffmann-La Roche
Sponsor class: INDUSTRY
First posted: 2015-10-01
Enrollment: 63
Sex: ALL
Minimum age (years): 18
Maximum age (years): 75
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NON_RANDOMIZED
Intervention model: SINGLE_GROUP
Primary purpose: TREATMENT

Brief summary: This study will evaluate the efficacy and safety of oral capecitabine plus intravenous (IV) gemcitabine in participants with locally advanced or metastatic pancreatic cancer. The anticipated time on study treatment is 3 to 12 months, and the target sample size is 56 individuals.


Eligibility criteria: Inclusion Criteria:

* Adult participants 18 to 75 years of age
* Locally advanced or metastatic pancreatic cancer

Exclusion Criteria:

- Prior chemotherapy for pancreatic cancer

Primary outcomes:
measure: Overall objective response rate
timeFrame: At the end of 6 cycles (24 weeks)
Secondary outcomes:
measure: Duration of response
timeFrame: Up to approximately 3.5 years
measure: Time to disease progression
timeFrame: Up to approximately 3.5 years
measure: Time to response
timeFrame: Up to approximately 3.5 years
measure: Time to treatment failure
timeFrame: Up to approximately 3.5 years
measure: Overall survival
timeFrame: Up to approximately 3.5 years
measure: Incidence of adverse events
timeFrame: Up to approximately 3.5 years
Other outcomes:
Locations:
city: Buchun
country: Korea, Republic of
city: Daegu
country: Korea, Republic of
city: Seoul
country: Korea, Republic of
city: Seoul
country: Korea, Republic of
city: Seoul
country: Korea, Republic of
city: Seoul
country: Korea, Republic of
city: Seoul
country: Korea, Republic of
Study officials:
affiliation: Hoffmann-La Roche
name: Clinical Trials
References:
Clinical trial NCT00531141: The Optical Coherence Tomography in Age-Related Macular Degeneration Study: The OCT in AMD Study
Official title: Reproducibility of Retinal Thickness Measurements by Optical Coherence Tomography in Age-Related Macular Degeneration The OCT in AMD Study
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Macular Degeneration
Keywords: age-related macular degeneration
optical coherence tomography
retinal thickness
exudative age-related macular degeneration
Lead sponsor: The Ludwig Boltzmann Institute of Retinology and Biomicroscopic Laser Surgery
Sponsor class: OTHER
First posted: 2007-09-18
Enrollment: 200
Sex: ALL
Minimum age (years): 50
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: primary care clinic

Brief summary: The Optical Coherence Tomography (OCT) is a non-contact, non invasive method to examine the retina by providing cross-sectional scans through the retina. Measurements of the retinal thickness based on automatically set border lines created by threshold algorithm provide information concerning the amount of intraretinal fluid and activity of the lesion. In this study the reproducibility of retinal thickness measurements in patients suffering from age-related macular degeneration performed by two independent examiners of two examinations of the same day but performed in a time interval of at least two hours should be evaluated. Using the macular thickness program of stratus OCT, 6 radial lines through the center of the foveal avascular zone are performed, Differences between the first and second measurement will be investigated by a 95% confidence interval, a Bland-Altman plot (with corresponding regression analysis) and a random effect model with time, examiner and diagnosis as fixed factors. Although threshold algorithm failures and fixation problems are common in age-related macular degeneration evidence of reproducibility and repeatability of maximum retinal thickness is expected.


Eligibility criteria: Inclusion Criteria:

* Age over 50 years
* Age related macular degeneration

Exclusion Criteria:

* Macular pathologies other than age related macular degeneration (diabetic maculopathy, macular pucker, macular hole,
* Visualization of the macula not possible (dens cataract, vitreous haemorrhage)
* Not consented patients

Primary outcomes:
Secondary outcomes:
Other outcomes:
Locations:
city: Vienna
country: Austria
facility: Ludwig Boltzmann Institute for Retinology and Biomicroscopic Lasersurgery
Study officials:
affiliation: Rudolf Foundation Clinic
name: Ilse Krebs, MD
role: PRINCIPAL_INVESTIGATOR
References:
citation: Krebs I, Hagen S, Brannath W, Haas P, Womastek I, de Salvo G, Ansari-Shahrezaei S, Binder S. Repeatability and reproducibility of retinal thickness measurements by optical coherence tomography in age-related macular degeneration. Ophthalmology. 2010 Aug;117(8):1577-84. doi: 10.1016/j.ophtha.2010.04.032. Epub 2010 Jun 16.
Clinical trial NCT04306341: Measuring the Impact of Real Time fMRI Neurofeedback in Borderline Personality Disorder
Official title: Measuring the Impact of Real Time fMRI Neurofeedback in Borderline Personality Disorder
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Borderline Personality Disorder
Lead sponsor: Yale University
Sponsor class: OTHER
Collaborators: name: AE Foundation
name: Central Institute of Mental Health, Mannheim
First posted: 2020-03-12
Enrollment: 3
Sex: ALL
Minimum age (years): 18
Maximum age (years): 50
Standard ages: ADULT
Accepts healthy volunteers: no
Allocation: NON_RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: This study will test the impacts of real time fMRI neurofeedback in patients with Borderline Personality Disorder. This is a pilot study in a small number of people enrolled in clinical programs at Yale New Haven Hospital.


Eligibility criteria: Inclusion Criteria:

1. enrolled in YNHH DBT-IOP
2. must meet specific clinical criteria
3. Inclusion in Experimental group requires participants meet standard safety and quality control requirements for MR scanning
4. For female participants, not pregnant and willing to use a reliable method of contraception during the study

Exclusion Criteria:

1. IQ\<70
2. vision problem not able to be corrected to normal range
3. medication changes w/in one month
4. Lifetime hx of schizophrenia, schizoaffective d/o, bipolar I disorder.
5. illicit substance use within 7 days of MRI scans
6. taking scheduled opiates
7. taking scheduled benzodiazepines
8. taking scheduled anti-histamines
9. history of seizures
10. significant current or past neurologic illness
11. BMI \< 16.5

Primary outcomes:
measure: Change in Affective Lability
timeFrame: Baseline compared to the week after intervention
Secondary outcomes:
measure: Change in Mean Negative Affect
timeFrame: Baseline compared to the week after intervention
measure: Change in Borderline Personality Disorder Symptoms
timeFrame: Baseline compared to the week after intervention
measure: Change in Amygdala Regulation
timeFrame: Baseline compared to the week after intervention
Other outcomes:
Locations:
city: New Haven
country: United States
facility: Connecticut Mental Health Center
state: Connecticut
Study officials:
affiliation: Yale University
name: Sarah K Fineberg, MD PhD
role: PRINCIPAL_INVESTIGATOR
affiliation: Yale University
name: Michelle Hampson, PhD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT06923241: Nutri-score Labelling in a UK Restaurant Setting: a Randomised Control Trial
Official title: Nutri-score Labelling in a UK Restaurant Setting: a Randomised Control Trial
Study type: INTERVENTIONAL
Overall status: RECRUITING
Phase: NA
Conditions: PME
Food Choice
Food Labelling
Keywords: Nutri-score
PME
Food choice
Lead sponsor: University of Liverpool
Sponsor class: OTHER
Collaborators: name: University of Bristol
name: Liverpool John Moores University
First posted: 2025-04-11
Enrollment: 450
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: PREVENTION

Brief summary: An experiment exploring the perceived effectiveness of Nutri-score food labels with calorie labelling compared to calorie labelling only on food choice and consumption in a real-world setting


Eligibility criteria: Inclusion Criteria:

* Can visit a restaurant in Liverpool city centre
* Regularly eat food prepared out of the home (from restaurants, cafes, fast food etc., at least once a month)
* Over the age of 18 years
* Fluent English speaker

Exclusion Criteria:

* Pregnant/breastfeeding
* You have been diagnosed with a current or historic eating disorder

Primary outcomes:
measure: Perceived Message Effectiveness
timeFrame: Up to 30 weeks
measure: Nutritional quality of each item and for the full meal
timeFrame: Up to 30 weeks
Secondary outcomes:
measure: NS label of each item selected
timeFrame: Up to 30 weeks
measure: Energy content of all food ordered
timeFrame: Up to 30 weeks
measure: Energy and nutrients consumed
timeFrame: Up to 30 weeks
measure: Later intake
timeFrame: Up to 30 weeks
Other outcomes:
Locations:
city: Liverpool
country: United Kingdom
facility: University of Liverpool
state: Merseyside
Study officials:
affiliation: University of Liverpool
name: Eric Robinson
role: PRINCIPAL_INVESTIGATOR
References: