Clinical trial NCT03621059: Behavioral Therapy for Children and Adolescents With Tourette Syndrome
Official title: Behavioral Therapy for Children and Adolescents With Tourette Syndrome: A Randomized Controlled Trial in Taiwan
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Tourette Syndrome
Keywords: Tourette syndrome
behavior therapy
children and adolescents
Lead sponsor: Taipei Medical University
Sponsor class: OTHER
First posted: 2018-08-08
Enrollment: 46
Sex: ALL
Minimum age (years): 6
Maximum age (years): 15
Standard ages: CHILD
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Intervention model description: A collection of behavioral skills named as Comprehensive Behavioral Intervention (CBIT) for Tics had been found to be effective (Piacentini et al., 2010).The major components of CBIT includes psychoeducation of tics, habit reversal training (HRT), function-based interventions, and relaxation training (Piacentini et al., 2010).The HRT consists of several therapeutic activities, including awareness training (i.e., observing the premonitory urge or other signs preceding the occurrence of a tic), competing response training (i.e., engaging in a voluntary behavior that is physically incompatible with the tic to manage the premonitory urge), self-monitoring of tics and relaxation training (Himle et al., 2006).
Primary purpose: TREATMENT

Brief summary: Tourette Syndrome (TS) is a common neuropsychiatric disorder in childhood and adolescence, and often comorbid with psychiatric comorbidity. Antipsychotic medications are usually the first choices, but may associate with adverse effects. Behavioral intervention for TS has been shown to be an effective treatment for children and adolescents, yet have not been performed and evaluated using control trails in Taiwan.

Detailed description: TS is a common neuropsychiatric disorder in childhood and adolescence, and often comorbid with psychiatric comorbidity. Antipsychotic medications are usually the first choices, but may associate with adverse effects. Behavioral intervention for TS has been shown to be an effective treatment for children and adolescents, yet have not been performed and evaluated using control trails in Taiwan. This study therefore was to evaluate the efficacy of a comprehensive behavioral intervention therapy on improving tics and tic-related impairment for children and adolescents with Tourette syndrome.

Eligibility criteria: Inclusion Criteria:

* DSM-5 Diagnostic Criteria For Tourette Syndrome
* Patients aged from 6-15 years who were diagnosed with TS or CTD,
* Never received any pharmacological treatment
* Ability to understand the study purpose and/or provide consent for participation independently and via a caregiver serving as a proxy

Exclusion Criteria:

* Have been diagnosed with another mental illness,
* Had no physical or medical condition,
* Had been received CBIT or cognitive behavior therapy before.

Primary outcomes:
measure: Eefficacy of a behavioral therapy on improving tics with Tourette syndrome
timeFrame: at 3rd month and 6rd months following treatment.
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
affiliation: Taipei Medical University
name: hsiu-ju Chang, PHD
role: PRINCIPAL_INVESTIGATOR
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