louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT01620619: The Role of Rotator Interval Closure in Bankart Lesion Repair
Official title: The Role of Rotator Interval Closure in Bankart Lesion Repair
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Bankart Lesions
Anterior Shoulder Instability
Keywords: Shoulder
Bankart
Anterior Instability
Rotator Cuff
Lead sponsor: University of Western Ontario, Canada
Sponsor class: OTHER
First posted: 2012-06-15
Enrollment: 142
Sex: ALL
Minimum age (years): 15
Maximum age (years): 51
Standard ages: CHILD
ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The null hypothesis is that there is no statistical difference between the two treatment groups for any outcome. The investigators suspect that patients who undergo a Bankart lesion repair with rotator interval closure will have lower quality of life and less external rotation compared to patients who undergo a Bankart lesion repair alone. No difference will be observed for recurrence rate between the two treatment groups

Detailed description: Research assessing the role and effectiveness of rotator interval closure is important to attempt to determine the most beneficial and efficient treatment for Bankart lesions and anterior shoulder instability. To date there is only weak evidence supporting the superiority of Bankart lesion repair in addition to rotator interval closure compared to Bankart lesion repair alone.

Does Bankart lesion repair with rotator interval closure result in differences in quality of life, range of motion and recurrence at 3 weeks, 6 weeks, 3 months, 6 months, 1 year and 2 years in similar patients with Bankart lesions who are treated with Bankart lesion repair alone?

Eligibility criteria: Inclusion Criteria:

* Patients between the ages of 15 to 50 years
* At least one episode of demonstrated dislocation
* Bankart lesion of the anterior glenoid labrum
* Absence of other capsular and tendon injuries
* Absence of glenoid fractures or divots

Exclusion Criteria:

* Posterior instability or the need for posterior surgical reconstruction
* Significant bone lesions greater than 3mm of the humeral head anterior-to- posterior (Hill-Sachs lesions)
* Presence of other pathologic conditions of the shoulder (excluding SLAP lesions)

Primary outcomes:
measure: Western Ontario Shoulder Instability Index
timeFrame: 3,6 weeks;3,6 months; 1,2 years
Secondary outcomes:
measure: Range of Motion
timeFrame: 3,6 months; 1-2 years
measure: 4-Item Pain Intensity Measure
timeFrame: 3,6, weeks; 3, 6 months; 1,2 years
measure: Upper Extremity Functional Index
timeFrame: 3,6 weeks; 3,6 months; 1,2 years
measure: Recurrence
timeFrame: 3,6 weeks; 3,6 months; 1,2 years
Other outcomes:
Locations:
city: London
country: Canada
facility: London Health Sciences Centre - Unviersity Hospital
state: Ontario
Study officials:
affiliation: The University of Western Ontario
name: Dianne Bryant, PhD
role: STUDY_DIRECTOR
References:
Clinical trial NCT05116319: Prediction to Detect Pre-DM/DM in a Chinese Population
Official title: Sensitivity and Specificity of Guidelines' Recommendations and Existing Predictive Models to Detect Undiagnosed Diabetes Mellitus or Prediabetes in a Chinese Population
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Diabetes Mellitus
Lead sponsor: Chinese University of Hong Kong
Sponsor class: OTHER
First posted: 2021-11-11
Enrollment: 1901
Sex: ALL
Minimum age (years): 25
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: ECOLOGIC_OR_COMMUNITY
Time perspective: CROSS_SECTIONAL
Sampling method: NON_PROBABILITY_SAMPLE
Study population: General Chinese population

Brief summary: This project will compare the sensitivity and specificity of different screening criteria or recommendations to detect pre-diabetes or diabetes mellitus in a Chinese population, using point-of-care hemoglobin A1c.


Eligibility criteria: Inclusion Criteria:

* age ≥25 years old
* with no previous diagnosis of DM
* Chinese.

Exclusion Criteria:

* a history of cardiovascular diseases including any type of stroke, ischemic heart disease, atrial fibrillation, and/or peripheral vascular disease
* severe mental or physical disease or language barriers that limited data collection

Primary outcomes:
measure: Point-of-care (POC) HbA1c
timeFrame: baseline
Secondary outcomes:
measure: Office blood pressure
timeFrame: baseline
measure: Body mass index
timeFrame: baseline
Other outcomes:
Locations:
city: Hong Kong
country: Hong Kong
facility: School of public health and primary care
Study officials:
References:
Clinical trial NCT00338819: ActiveCare+SFT Hemodynamic Profile Compare to SCD Express in Ventilated Patients
Official title: ActiveCare+SFT Hemodynamic Profile Compare to SCD Express in Ventilated Patients
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: DVT Prevention
Ventilated Patients
Keywords: DVT prevention
Hemodynamic study
IPC
CECT
Lead sponsor: Tel-Aviv Sourasky Medical Center
Sponsor class: OTHER_GOV
First posted: 2006-06-20
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: DEFINED_POPULATION
Time perspective: OTHER

Brief summary: Purpose:

To test the hemodynamic profile generated by the MCS's ActiveCare+SFT device in ventilated patients and compare it to that of the Kendall SCD Express.

Design:

Comparative, prospective study. Patients are their own controls.


Eligibility criteria: Inclusion Criteria:

* Adult ventilated patient (Age \>18).
* The patient or his guardian is able and voluntarily prepared to sign the Informed Consent Form.

Exclusion Criteria:

* Known, preexisting DVT or PE.
* Patient who is participating in another clinical trial.
* Patient with contraindication to use of the device including patients with leg gangrene, recent skin graft or medical situations where increase venous and lymphatic return is undesirable.

Primary outcomes:
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
affiliation: Tel-Aviv Sourasky Medical Center
name: Sorkine, Prof
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT03532919: Heart and Renal Failure in Hip Fracture Surgery
Official title: Heart and Renal Failure in Hip Fracture Surgery
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Hypotension
Hip Fractures
Renal Insufficiency
Heart Injuries
Lead sponsor: Sahlgrenska University Hospital
Sponsor class: OTHER
First posted: 2018-05-22
Enrollment: 105
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: CASE_CONTROL
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Patients with an acute hip fracture classified as being ASA 3 or more

Brief summary: Patients with acute hip fractures are old and vulnerable. With a majoriry classified as being ASA 3 or more. Frequently they receive spinal anesthesia perioperatively inducing hypotension. Even a short hypotensive period may induce postop cardiac T roponinT leakage as well as renal failure noted by Changes in Serum Creatinin or Cýstatin C This will be investigated and correlated to intraoperative hypotension as step one. Preliminary this will be followed by an intervention with vasopressor treatment perioperatively to preserve an adequte MABP

Detailed description: Patients with acute hip fractures are old and vulnerable. With a majoriry classified as being ASA 3 or more. Frequently they receive spinal anesthesia perioperatively inducing hypotension. Even a short hypotensive period may induce postop cardiac T roponinT leakage as awell as renal failure noted by Changes in S Creatinin or Cýstatin C This will be investigated and correlated to intraoperative hypotension as a step one. Preliminary this will be followed by an intervention with vasopressor treatment perioperatively to preserve an adequte MABP

Eligibility criteria: Inclusion Criteria:

* Hip fracture patient to be operated upon Classified as being ASA 3 or more

Exclusion Criteria:

* Not forfilling inclusion Criterias

Primary outcomes:
measure: Mortality
timeFrame: 90 days
Secondary outcomes:
measure: Serum concentrations of Troponin, NTproBNP, Creatinin and Cystatin C
timeFrame: 90 days
Other outcomes:
Locations:
city: Molndal
country: Sweden
facility: Sahlgrenska University Hospital
state: Vastra Gotaland
Study officials:
affiliation: SahlgrenskaUniversity Hospital
name: Bengt M Nellgard, MD PhD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT00451919: The Link Between Anemia and Deficits in Memory and Attention in Individuals With Sickle Cell Disease
Official title: Sickle-Cell Disease: Neuroimaging and Cognitive Decline
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Sickle Cell Disease
Keywords: MRI
Neuropsychology
Lead sponsor: National Heart, Lung, and Blood Institute (NHLBI)
Sponsor class: NIH
Collaborators: name: University of California, San Francisco
First posted: 2007-03-26
Enrollment: 120
Sex: ALL
Minimum age (years): 21
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes

Brief summary: Sickle cell disease is an inherited blood disorder that affects red blood cells (RBCs). People with sickle cell disease frequently experience anemia, or a low number of RBCs. RBCs are responsible for carrying oxygen to the brain and other body tissues that need oxygen to function properly. The purpose of this study is to determine what changes, which were possibly caused by anemia, exist in the brains of individuals with sickle cell disease.

Detailed description: The role of RBCs is to carry oxygen from the lungs to the brain and other body tissues. Individuals with anemia have unusually low numbers of RBCs. They also often have difficulty concentrating and remembering information, which is likely caused by a reduced oxygen supply to the brain. Previous research has shown that correcting anemia in patients without sickle cell disease improved their memory and attention. The purpose of this study is to examine any abnormal changes in the brains of individuals with sickle cell disease and to determine whether these changes are related to reduced memory and attention capabilities.

Participants will attend one study visit. During this visit, a brain magnetic resonance image (MRI) will be performed while participants complete neuropsychological tests that measure memory, attention, and organizational ability. There will be no follow-up visits.

The study completion date listed in this record was obtained from the "End Date" entered in the Protocol Registration and Results System (PRS) record.

Eligibility criteria: Inclusion Criteria:

* Diagnosis of sickle cell disease

Exclusion Criteria:

* Pregnancy
* Claustrophobia
* Mass lesion (e.g., meningioma, cyst, or spinal block)
* Need for life support constant monitoring
* Any unstable condition that is likely to require resuscitation
* Presence of a pacemaker or other iron-containing magnetic substances in the body

Primary outcomes:
Secondary outcomes:
Other outcomes:
Locations:
city: San Francisco
country: United States
facility: University of California San Francisco
state: California
Study officials:
affiliation: University of California, San Francisco
name: Randall R. Rule, PhD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT02318719: DS-5565 Phase III Study for Post-herpetic Neuralgia
Official title: An Asian, Phase 3, Multicenter, Randomized, Double-blind, Placebo-controlled 14-Week Study of DS-5565 in Patients With Post-herpetic Neuralgia Followed by a 52-Week Open-label Extension
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Post-Herpetic Neuralgia
Keywords: Post-Herpetic Neuralgia
Developmental Phase III
Lead sponsor: Daiichi Sankyo
Sponsor class: INDUSTRY
Collaborators: name: SRL Medisearch Inc.
name: Quintiles, Inc.
First posted: 2014-12-17
Enrollment: 765
Sex: ALL
Minimum age (years): 20
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: Investigate the efficacy and safety of DS-5565 in subjects with Post-Herpetic Neuralgia (PHN) in comparison to placebo

Detailed description: \[Double Blind Phase\] The primary objective is to compare change in the Average Daily Pain Score (ADPS) from baseline to Week 14 in Asian subjects with PHN receiving DS-5565 versus placebo.

\[Open Extension Phase\] The objective is to assess the long-term safety and efficacy of DS-5565 in subjects with PHN.

Eligibility criteria: Inclusion Criteria:

* PHN defined as pain present for more than 3 months after herpes zoster skin rash at screening
* At screening, a pain scale of ≥ 40 mm

Exclusion Criteria:

* Previous use of neurolytic block

Primary outcomes:
measure: Change in the Average Daily Pain Score (ADPS) From Baseline to Week 14 Following Oral Administration of DS-5565 in Asian Participants With Post-herpetic Neuralgia
timeFrame: Baseline to Week 14
Secondary outcomes:
measure: Change in Visual Analog Scale (VAS) Pain From Baseline (Week 14) to Week 66 Following Administration of DS-5565 in Asian Participants With Post-herpetic Neuralgia
timeFrame: From baseline (Week 14) to Week 66
Other outcomes:
Locations:
city: Oita
country: Japan
facility: Medical Corporation Fujigaki Clinic
Study officials:
affiliation: Daichii Sankyo
name: Global Clinical Leader
role: STUDY_DIRECTOR
References:
citation: Kato J, Baba M, Kuroha M, Kakehi Y, Murayama E, Wasaki Y, Ohwada S. Safety and Efficacy of Mirogabalin for Peripheral Neuropathic Pain: Pooled Analysis of Two Pivotal Phase III Studies. Clin Ther. 2021 May;43(5):822-835.e16. doi: 10.1016/j.clinthera.2021.03.015. Epub 2021 May 29.
citation: Kato J, Matsui N, Kakehi Y, Murayama E, Ohwada S. Long-term safety and efficacy of mirogabalin in Asian patients with postherpetic neuralgia: Results from an open-label extension of a multicenter randomized, double-blind, placebo-controlled trial. Medicine (Baltimore). 2020 Sep 4;99(36):e21976. doi: 10.1097/MD.0000000000021976.
Clinical trial NCT06675019: The Effect of Manual Therapy Versus Kinesio Taping on Tension-type Headache in Jouf University Female Students
Official title: The Effect of Manual Therapy Versus Kinesio Taping on Tension-type Headache in Jouf University Female Students
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Tension Type Headache
Keywords: tension type headache
manual therapy
kinesio taping
Lead sponsor: Cairo University
Sponsor class: OTHER
First posted: 2024-11-05
Enrollment: 45
Sex: FEMALE
Minimum age (years): 18
Maximum age (years): 25
Standard ages: ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: Patients suffering from Tension Type Headache (TTH) report emotional and functional deficits (missing work, sleep disorders, emotional stability) and are susceptible to pharmaceutical abuse. Cervical muscle training, posture correction, spinal mobilization, and other physical therapy modalities may help alleviate symptoms.

This study will aim to compare the effect of manual therapy and kinesio taping on tension-type headache.


Eligibility criteria: Inclusion Criteria:

* Students between the ages of 18 and 25 will be enrolled in the study if they have tension type headache based on the IHS headache classification: A headache that occurs at least 15 days per month for more than 3 months (≥ 180 days per year) and lasts for hours or is continuous. The headache exhibits at least one of the following characteristics: 1. bilateral location, 2. pressing/tightening (non-pulsating) character, 3. mild or moderate intensity that is not exacerbated by routine physical activity such as walking or ascending stairs, and both of the following: 1. No more than one of photophobia, phonophobia, or mild nausea, and 2. No moderate to severe nausea or vomiting.

Exclusion Criteria:

* Reumatoid arthritis, suspected malignancy, pregnancy, regular use of triptans, ergotamines, or opioids on ≥ 10 days/month or simple analgesics on ≥ 15 days/month for ≥ 3 months, or physical therapy treatment within 2 months prior to enrollment in the study.

Primary outcomes:
measure: Visual Analouge Scale
timeFrame: 8 weeks
Secondary outcomes:
measure: The 6-item headache questionnaire
timeFrame: 8 weeks
measure: A headache diary
timeFrame: 8 weeks
Other outcomes:
Locations:
city: Giza
country: Egypt
facility: Faculty of Physical Therapy, Cairo University
Study officials:
References:
Clinical trial NCT03718819: Effects of Exercises in MS on Postural Control With Dual Task
Official title: Effects of Combined Exercises on Postural Control With and Without Dual Task in Patients With Multiple Sclerosis
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Multiple Sclerosis
Keywords: multiple sclerosis
pilates
aquatherapy
postural control
dual task
Lead sponsor: Dokuz Eylul University
Sponsor class: OTHER
First posted: 2018-10-24
Enrollment: 13
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: TREATMENT

Brief summary: Multiple sclerosis is a progressive neurological disease that associated with demyelinization and axonal damage. Decreased postural control is one of the initial symptom of disease. Improving postural control in people with neurological impairment is a common goal of physiotherapy. Doing exercises in water or land are examples for effective solutions. Pilates and aquaplyometric exercises are some of these approaches.

Performing daily activities at the same time requires dual tasking or multi tasking. Dual tasking is frequently impaired in MS. The aim of the study was to determine effect of combined Pilates and Aquaplyometric exercises on postural control with or without dual task in patients with multiple sclerosis.

Detailed description: MS patients with decreased postural control will be enrolled eight-week, 45 minutes combined Pilates and aquaplyometric exercise programme. Postural control, hand dexterity and other functional parameteres will assess besaline and at the eighth week of exercise programme by the physiotherapist. Postural control will evaluate with and without dual task.

Eligibility criteria: Inclusion Criteria:

* being over 18 years old
* ability to walk independently or with single walking aid
* having stable symptoms

Exclusion Criteria:

* being acute or unstable phase of disease
* having EDSS score\>6
* insuitable for the pool (incontinance, dermatological disease etc.)

Primary outcomes:
measure: Change in limits of stability parameter with Biodex Balance System
timeFrame: Baseline and 8 weeks
measure: Change in limits of stability parameter with cognitive task by Biodex Balance System
timeFrame: Baseline and 8 weeks
Secondary outcomes:
measure: Change in Nine hole peg Test
timeFrame: Baseline and 8 weeks
measure: Change in timed up and go test
timeFrame: Baseline and 8 weeks
measure: Change in 5-Repetititon Sit-To-Stand Test
timeFrame: Baseline and 8 weeks
measure: Change in timed 25 step walking test
timeFrame: Baseline and 8 weeks
measure: Handgrip strength test
timeFrame: Baseline and 8 weeks
Other outcomes:
Locations:
city: İzmir
country: Turkey
facility: Dokuz Eylül University, School of Physical Therapy and Rehabilitation
state: Balçova
Study officials:
affiliation: Dokuz Eylul University
name: Barış Gürpınar, PhD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT03027219: Blood Flow Change After Free Flap Surgery in Diabetic Patients
Official title: Prospective Observational Study of the Changes of Blood Flow of Arterial Anastomosis-site of Free Flap in Diabetic Patients Who Undergoing Free Flap Transfer
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Diabetes
Lead sponsor: Asan Medical Center
Sponsor class: OTHER
First posted: 2017-01-23
Enrollment: 44
Sex: ALL
Minimum age (years): 18
Maximum age (years): 79
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: CASE_ONLY
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Diabetic patients who are undergoing free flap surgery

Brief summary: We aim to evaluate the flow change of arterial anastomosis site during free flap surgery in diabetic patients.

Detailed description: Objective: flow change of arterial anastomosis site during free flap surgery in diabetic patients.

Background: No research was published about flow change of arterial anastomosis site of the free flap during surgery.

Plan: Using Duplex sonography, various parameters related flap perfusion will be evaluated before and after the administration of alprostadil.

Eligibility criteria: Inclusion Criteria:

1. Plan to receive free flap transfer under general anesthesia
2. Age: \>=18 and \<80 years old
3. History of diabetes mellitus
4. Administration of alprostadil during surgery
5. Volunteer, who are provided written informed consent prior to study participation

Exclusion Criteria:

1. Refuse the participation of study
2. \>= American society of anesthesiologist physical status IV
3. Use of any vasopressor or inotropic for hemodynamic instability before participation of study
4. Inappropriate subjects who are identified by researchers

Primary outcomes:
measure: Flow change
timeFrame: before alprostadil administration, 30 mins after alprostadil administration
Secondary outcomes:
Other outcomes:
Locations:
city: Seoul
country: Korea, Republic of
facility: Asan Medical Center
Study officials:
affiliation: Asan Medical Center
name: Young-kug Kim, MD, PhD
role: PRINCIPAL_INVESTIGATOR
References: