Clinical trial NCT03860441: Effects of Cognitive Intervention on Cognition, Mobility and Brain Electrocortical Activity
Official title: Holistic Approach for Active and Healthy Aging: Physical and Cognitive Activity, and Nutrition
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Cognitive Decline
Cognitive Impairment
Aging
Motor Coordination or Function
Keywords: cognition
mobility
cognitive reserve
EEG/ERP
Lead sponsor: Science and Research Centre Koper
Sponsor class: OTHER
Collaborators: name: University of Primorska
name: Albert Einstein College of Medicine
name: Vrije Universiteit Brussel
First posted: 2019-03-04
Enrollment: 77
Sex: ALL
Minimum age (years): 60
Maximum age (years): 90
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Intervention model description: Participants in the intervention group followed a computerized cognitive training program for 2-months, 3x/week, 40min/session
Primary purpose: TREATMENT

Brief summary: Within this project the investigators tested the effectiveness of 2-month of computerized cognitive training (CCT) on CogniFit online platform on 77 older adults, which were randomly divided into intervention and control group. The investigators tested close (battery of cognitive functions) and far transfer (postural and mobility control, EEG, blood samples) of the CCT. Additionally, the investigators were interested into seeing a long-lasting effect, therefore participants were brought back to the laboratory 1 year post CCT.


Eligibility criteria: Inclusion Criteria:

* active and healthy older adults with no major health issues
* members of the Center for Daily Activity Koper (Slovenia)
* had normal or corrected-to-normal vision;
* reported no history of cardiovascular, neurological, or psychiatric conditions

Exclusion Criteria:

* younger than 60
* smoking; regular alcohol consumption;
* acute or chronic skeletal, neuromuscular, metabolic and cardiovascular disease condition;

Primary outcomes:
measure: Change in gait speed
timeFrame: up to 8 weeks
Secondary outcomes:
measure: Executive control (Trail-Making Task Forms A and B)
timeFrame: up to 8 weeks
measure: Sensorimotor integration measured with EEG/ERP methodology
timeFrame: up to 8 weeks
measure: Brain-derived neurotrophic factor (BDNF) extracted from peripheral blood sampling
timeFrame: up to 8 weeks
Other outcomes:
Locations:
city: Koper
country: Slovenia
facility: Center for Daily Activity Koper (Slovenia)
Study officials:
References:
citation: Marusic U, Kavcic V, Giordani B, Gerzevic M, Meeusen R, Pisot R. Computerized spatial navigation training during 14 days of bed rest in healthy older adult men: Effect on gait performance. Psychol Aging. 2015 Jun;30(2):334-340. doi: 10.1037/pag0000021. Epub 2015 May 4.
citation: Verghese J, Mahoney J, Ambrose AF, Wang C, Holtzer R. Effect of cognitive remediation on gait in sedentary seniors. J Gerontol A Biol Sci Med Sci. 2010 Dec;65(12):1338-43. doi: 10.1093/gerona/glq127. Epub 2010 Jul 19.
citation: Marusic U, Verghese J, Mahoney JR. Cognitive-Based Interventions to Improve Mobility: A Systematic Review and Meta-analysis. J Am Med Dir Assoc. 2018 Jun;19(6):484-491.e3. doi: 10.1016/j.jamda.2018.02.002. Epub 2018 Apr 19.