Clinical trial NCT03827239: Investigation of the Effects of Sedentary Behaviour and Moderate Exercise on Glucose Tolerance and Insulin Sensitivity
Official title: Investigation of the Effects of Sedentary Behaviour and Moderate Exercise on Glucose Tolerance and Insulin Sensitivity
Study type: INTERVENTIONAL
Overall status: TERMINATED
Phase: NA
Conditions: Sedentary Lifestyle
Insulin Sensitivity
Glucose Metabolism
Lead sponsor: University of Prince Edward Island
Sponsor class: OTHER
First posted: 2019-02-01
Enrollment: 6
Sex: ALL
Minimum age (years): 18
Maximum age (years): 50
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: CROSSOVER
Primary purpose: PREVENTION

Brief summary: Individuals with pre-diabetes or diabetes would benefit from low impact methods that would improve their insulin sensitivity and aid in maintaining glucose homeostasis. Physical activity helps the body decrease its insulin resistance and burn excess sugar. Many diabetics also suffer from obesity and specific forms or durations of physical exercise may not be viable options for these individuals. Determining whether short bursts of moderate exercise improve blood glucose levels in healthy humans may identify a further method for diabetics to improve their glucose homeostasis.

The aim of this study is to determine the most effective moderate exercise that can be completed in 3 minutes and its effectiveness on improving glucose handling, in response to a single day of standardized high-fat and high-carbohydrate feeding in comparison to periods of prolonged sitting.


Eligibility criteria: Inclusion Criteria:

* healthy
* BMI between 18-30 kg/m²
* non-smoker

Exclusion Criteria:

* pregnant
* diabetes
* kidney disease
* liver disease
* cardiovascular disease
* cancer

Primary outcomes:
measure: Change in Insulin levels
timeFrame: Pre-prandial baseline (12 hours fasted) and 3 hours post-prandial on each of two testing days
measure: Change in concentration of C-peptide
timeFrame: Pre-prandial baseline (12 hours fasted) and 3 hours post-prandial on each of two testing days
measure: Changes in blood glucose levels
timeFrame: Baseline and every 30-60 minutes over 3 hours (6 timepoints per test day)
measure: Change in metabolomic response to a test meal
timeFrame: Pre-prandial and 3-hours post test meal through study completion
Secondary outcomes:
measure: Immediate effects of short-term sedentary behaviour on cognitive function
timeFrame: 3 hours post-activity (sedentary behaviour or exercise) on test days through study completion
measure: Immediate effects of short-term sedentary behaviour on cognitive function
timeFrame: 3 hours post-activity (sedentary behaviour or exercise) on test days through study completion
measure: Immediate effects of short-term sedentary behaviour on cognitive function
timeFrame: 3 hours post-activity (sedentary behaviour or exercise) on test days through study completion
measure: Immediate effects of short-term sedentary behaviour on cognitive function
timeFrame: 3 hours post-activity (sedentary behaviour or exercise) on test days through study completion
measure: Immediate effects of short-term sedentary behaviour on cognitive function
timeFrame: 3 hours post-activity (sedentary behaviour or exercise) on test days through study completion
measure: Gene expression levels in isolated PBMC populations
timeFrame: Pre-prandial and 3 hours post-prandial on on test days through study completion
Other outcomes:
Locations:
city: Charlottetown
country: Canada
facility: University of Prince Edward Island
state: Prince Edward Island
Study officials:
affiliation: University of Prince Edward Island
name: Magdalena Mahlstedt, PhD
role: STUDY_DIRECTOR
References: