louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT05829941: Technology Assisted Treatment for Binge Eating Behavior
Official title: Technology Assisted Treatment for Binge Eating Behavior
Study type: INTERVENTIONAL
Overall status: NOT_YET_RECRUITING
Phase: NA
Conditions: Binge-Eating Disorder
Lead sponsor: HabitAware Inc.
Sponsor class: INDUSTRY
Collaborators: name: University of Minnesota
First posted: 2023-04-26
Enrollment: 30
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: OTHER

Brief summary: Binge-eating behavior is a central feature of eating disorders (e.g., binge-eating disorder, bulimia nervosa, anorexia nervosa-binge-eating/purging subtype) and is associated with higher rates of psychopathology, psychosocial impairment, medical comorbidity, and more severe obesity, all of which pose significant public health problems. Passive detection of binge eating episodes combined with a context-based reminder intervention could assist a patient in resuming healthy eating patterns. This study will test a smartwatch app that identifies binge eating behavior and provides CBT strategies to the patient after the episode.


Eligibility criteria: Inclusion Criteria:

1. Adults ≥18 years of age
2. EDE diagnosis of bulimia nervosa or binge eating disorder, with binge-eating episodes occurring at least 2x/week

Exclusion Criteria:

1. Pregnancy or lactation
2. Acute medical or psychiatric risk
3. Psychosis or bipolar disorder (lifetime history)
4. Current substance use disorder within the past six months
5. BMI less than 18.5 kg/m2
6. Acute suicidality requiring hospitalization
7. Food allergies
8. Receiving current psychotherapy
9. On psychotropic medications that have not been on a stable dose for at least six weeks

Primary outcomes:
measure: Percentage of patients in the HabitAware condition that report the treatment is acceptable.
timeFrame: 8 weeks
Secondary outcomes:
measure: Percentage of patients report that the binge episode detection is accurate
timeFrame: 8 weeks
Other outcomes:
Locations:
Study officials:
References:
Clinical trial NCT00581841: Repeatability of X-Ray, MRI, and Gait Analysis
Official title: Repeatability of X-Ray, MRI, and Gait Analysis
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Healthy
Keywords: Healthy adult normals
Lead sponsor: Mayo Clinic
Sponsor class: OTHER
Collaborators: name: National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
First posted: 2007-12-28
Enrollment: 60
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Community sample

Brief summary: The purpose of this preliminary substudy to the parent study "Aerobic Exercise Intervention for Knee Osteoarthritis" is to determine the repeatability and reproducibility of various measurement techniques.

Detailed description: The purpose of this preliminary substudy to the parent study "Aerobic Exercise Intervention for Knee Osteoarthritis" is to determine the repeatability and reproducibility of various measurement techniques. The study will enroll healthy volunteers. All participants will receive x-rays and MRI examinations of the knees. Walking characteristics will be evaluated in a Motion Analysis Lab; this will involve taping reflective markers to participants' skin and having them walk on a level surface and up and down stairs. All participants will be evaluated two times, with a 1-week period between evaluations.

Eligibility criteria: Inclusion Criteria:

* Healthy adults

Exclusion Criteria:

* Previous knee injury, knee pain, or knee osteoarthritis

Primary outcomes:
measure: Day-to-day and inter/intra examiner repeatability of the techniques to be used in NIH grant R01 AR48768
timeFrame: Measured two times, with a 1-week period between evaluations
Secondary outcomes:
Other outcomes:
Locations:
city: Rochester
country: United States
facility: Mayo Clinic
state: Minnesota
Study officials:
affiliation: Mayo Clinic
name: Kenton R. Kaufman, PhD
role: PRINCIPAL_INVESTIGATOR
References:
citation: Schmidt JE, Amrami KK, Manduca A, Kaufman KR. Semi-automated digital image analysis of joint space width in knee radiographs. Skeletal Radiol. 2005 Oct;34(10):639-43. doi: 10.1007/s00256-005-0908-9. Epub 2005 May 25.
citation: Grochowski SJ, Amrami KK, Kaufman K. Semi-automated digital image analysis of patellofemoral joint space width from lateral knee radiographs. Skeletal Radiol. 2005 Oct;34(10):644-8. doi: 10.1007/s00256-005-0944-5. Epub 2005 Jul 15.
citation: Koff MF, Amrami KK, Kaufman KR. Clinical evaluation of T2 values of patellar cartilage in patients with osteoarthritis. Osteoarthritis Cartilage. 2007 Feb;15(2):198-204. doi: 10.1016/j.joca.2006.07.007. Epub 2006 Sep 1.
citation: Agnesi F, Amrami KK, Frigo CA, Kaufman KR. Semiautomated digital analysis of knee joint space width using MR images. Skeletal Radiol. 2007 May;36(5):437-44. doi: 10.1007/s00256-006-0245-7. Epub 2007 Jan 23.
Clinical trial NCT02304341: Development of a Modified Pediatric Early Warning Score: a French Prospective Multicentre Regional Study
Official title: Development of a Modified Pediatric Early Warning Score: a French Prospective Multicentre Regional Study.
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Critical Illness
Keywords: critical illness
disease progression
child
severity of illness index
monitoring
Lead sponsor: University Hospital, Lille
Sponsor class: OTHER
Collaborators: name: Ministry of Health, France
First posted: 2014-12-01
Enrollment: 3016
Sex: ALL
Minimum age (years): 1
Maximum age (years): 18
Standard ages: CHILD
ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: Children admitted to the paediatric inpatient unit in 7 regional hospitals French

Brief summary: Children are admitted in intermediate units when the severity requires continuous monitoring. In France, Resources allocated to intermediate units are determined from lists of diagnoses and associated acts to additional budget. A score to assess the severity of illness may be associated with acts to develop an activity indicator easy to use. The investigators have chosen 2 scores to assess severity in intermediate cares : the Paediatric Advanced Warning Score (PAWS) and the Bedside Pediatric Early System Score (PEWS). In France, they have not been validated. The correlation between the severity of children and the associated diagnoses and acts has not been studied. The main objective of this study is to validate these 2 scores. The secondary objective is to determine a simplified activity indicator.


Eligibility criteria: Inclusion Criteria:

* All children admitted to the paediatric inpatient unit

Exclusion Criteria:

* parental refusal

Primary outcomes:
measure: Changed inPaediatric Advanced Warning Score (PAWS)
timeFrame: at admission and each 8 hours, up to 5 days
Secondary outcomes:
measure: Changed in Pediatric Early Warning System score (PEWS)
timeFrame: at admission and each 8 hours, up to 5 days
measure: Transfer in pediatric intensive care (YES/NO)
timeFrame: at each 8 hours, up to 5 days
Other outcomes:
Locations:
city: Arras
country: France
facility: Centre Hospitalier Général
city: Boulogne sur mer
country: France
facility: Centre hospitalier général
city: Cambrai
country: France
facility: Centre Hospitalier Général
city: Douai
country: France
facility: Centre Hospitalier Général
city: Dunkerque
country: France
facility: Centre Hospitalier général
city: Lens
country: France
facility: Centre Hospitalier Général
city: Roubaix
country: France
facility: Centre Hospitalier Général
Study officials:
affiliation: Lille University Hospital
name: Stephane LETEURTRE, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT02919241: Diagnostic Interview and One-session Cognitive Therapy in Treatment of Dental Fear
Official title: An Application of Treatment Regarding a Diagnostic Interview and One-session Cognitive Behavioural Therapy - Effectiveness in Treatment of Dental Fear
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Dental Fear
Keywords: dental anxiety
cognitive therapy
Lead sponsor: University of Eastern Finland
Sponsor class: OTHER
First posted: 2016-09-29
Enrollment: 29
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: NON_RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: Clinical trial of an application of cognitive behavioural one-session therapy method with patients who have severe or average dental fear/anxiety measured by Modified Dental Anxiety Scale (MDAS). The intervention consists of two different parts: a diagnostic interview and one-session treatment of dental care. The method is based on One-Session Therapy manual (Öst \& Skaret, 2013). 30 minimum 18 years old adults takes part to the study. They comes from three different places,primary care clinic, community dental care and dentist´s teaching clinic.

Detailed description: Purpose is to compare diagnostic interview (n=20) to diagnostic interview and one-session treatment of dental care (n=10). Partners come from three different places, 10 from each: public and private dental care and dental school. Participants from dental school take part to one-session treatment. All participants have normal dental care before final interview. Hypotheses is that dental fear/anxiety will decrease one category (5 points) when measured by Modified dental anxiety scale (MDAS) before the intervention and after normal dental care. Visual Analogue Scale is used to measure the strength of unpleasant feeling before and after intervention in both groups.

Eligibility criteria: Inclusion Criteria:

* MDAS 13 or over, dental care in normal circumstances doesn´t work, motivation to treat dental fear, minimum 18 year

Exclusion Criteria:

* Mental disorder, dementia, pregnancy, acute state of somatic illness

Primary outcomes:
measure: Change in dental fear
timeFrame: 6 months
Secondary outcomes:
measure: Compliance to care
timeFrame: 6 months
Other outcomes:
Locations:
city: Kuopio
country: Finland
facility: University of Eastern Finland
Study officials:
affiliation: University of easthern Finland, Kuopio
name: Liisa Suominen, Professor
role: STUDY_DIRECTOR
References:
citation: Kurki P, Korhonen M, Honkalampi K, Suominen AL. Patients' multifaceted views of dental fear in a diagnostic interview. Acta Odontol Scand. 2021 Apr;79(3):194-204. doi: 10.1080/00016357.2020.1817545. Epub 2020 Sep 12.
Clinical trial NCT05455541: Reliability of Artificial Intelligence (AI)-Augmented Point-of-care Cardiac Ultrasound in the Hands of Internists
Official title: Reliability of Artificial Intelligence (AI)-Augmented Point-of-care Cardiac Ultrasound (POCCUS) in the Hands of Internists
Study type: OBSERVATIONAL
Overall status: RECRUITING
Conditions: Cardiovascular Diseases
Valvular Heart Disease
Lead sponsor: Sheba Medical Center
Sponsor class: OTHER_GOV
First posted: 2022-07-13
Enrollment: 300
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Hospitalized patients in the internal medicine or geriatrics department that have an accepted indication for a POCUS study

Brief summary: The study aim is to test the diagnostic performance of internists interpreting echo images aided by the AISAP CARDIO V0.7 diagnostic support system. Ground truth will be established by an interpretation by cardiologists specialized in echo, of the same POCUS images (acquired by the internist \\ sonographer ).

Up to 1000 subjects; Study population will be distributed according to the following schema:

Group 1 -up to 800 patients hospitalized in the Internal Medicine division Group 2 - up to 200 patients hospitalized in the acute Geriatric division


Eligibility criteria: Inclusion Criteria:

1. Clinically indicated POCUS cardiac assessment as determined by the treating physicians for an accepted clinical indication
2. Willing and able to provide consent for a short partial transthoracic POCCUS examinations
3. No urgent or other compelling need for a comprehensive echo exam by the echo lab.

Exclusion Criteria:

1. Unstable clinical condition that does not permit any reasonable delay necessary to obtain consent and perform the POCCUS
2. Severe thoracic deformation or thoracic wall infection or wound that does not permit an adequate echocardiographic examination
3. Very poor or non-diagnostic echocardiographic imaging quality on prior echocardiography examinations.
4. Patients after lung resection
5. Patients unable lie in bed and undergo a standard echo study
6. Participation in an interventional study

Primary outcomes:
measure: Degree of agreement
timeFrame: 30 days
measure: Clinical significant findings detected by the internist utilizing AI-aided POCUS
timeFrame: 30 days
Secondary outcomes:
measure: Percent of POCUS images of good quality
timeFrame: 30 days
measure: Loops that AI interpreted
timeFrame: 30 days
Other outcomes:
Locations:
city: Ramat Gan
country: Israel
facility: Sheba Medical Center
Study officials:
References:
Clinical trial NCT00671541: Nasospore Stent For Use in Enodscopic Sinus Surgery
Official title: Nasospore Stent For The Use in Endoscopic Sinus Surgery
Study type: INTERVENTIONAL
Overall status: WITHDRAWN
Phase: PHASE4
Conditions: Chronic Sinusitis
Lead sponsor: Lahey Clinic
Sponsor class: OTHER
First posted: 2008-05-05
Enrollment: 0
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NON_RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The purpose of this study is to evaluate a stenting material called Nasopore. This is a synthetic material approved by FDA for use as a stent in postoperative sinus surgery patients. This study will compare the Nasopore stent to other approved stenting materials.

Detailed description: This study will compare other sinus stenting products to the Nasopore stent. The stents will be soaked in antibiotic solutions and be observed for how well they perform. Subjects will have a stent placed in each sinus, stents may be the standard antibiotic saturated materials or the new nasopore material or nasopore stent soaked in antibiotics.

Eligibility criteria: Inclusion Criteria:

* Evaluation by Otolaryngologist \& determined to need endoscopic sinus surgery
* Only subjects with Bilateral disease

Exclusion Criteria:

* Pediatric subjects(under the age of 18)

Primary outcomes:
measure: This study will evaluate the efficacy of nasopore stent soaked in bacitracin in and one stent soaked in gentaymcin antibiotic solution
timeFrame: prospective
Secondary outcomes:
Other outcomes:
Locations:
city: Burlington
country: United States
facility: Lahey Clinic, Inc
state: Massachusetts
Study officials:
affiliation: Lahey Clinic
name: Peter J. Catalano, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT06325241: Validating the Use of Frailty Measurements to Predict Care & Quality of Life
Official title: Validating the Use of Frailty Measurements to Predict Care Expectations and Deteriorations in Quality of Life Among People With COPD: A Prospective Cohort Study
Study type: OBSERVATIONAL
Overall status: ACTIVE_NOT_RECRUITING
Conditions: Chronic Obstructive Pulmonary Disease
Keywords: Frailty
Care expectations
Lead sponsor: Ottawa Hospital Research Institute
Sponsor class: OTHER
First posted: 2024-03-22
Enrollment: 123
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: French or English speaking outpatients of the Ottawa Hospital Respirology clinic who are diagnoses with Chronic Obstructive Pulmonary Disease, which is confirmed by pulmonary function testing who are able to speak on the phone for at least 10 minutes.

Brief summary: The aim of this research program is to validate frailty measurements as a risk stratification tool to predict deteriorations in patient-reported outcomes, to gain a better understanding of patient preferences for care within varying degrees of frailty, and to assess differences in frailty measurement between patients and their clinicians.

This work will provide a foundation in the development of customized interventions for people with COPD and varying degrees of frailty, with the goal of improving quality of life and optimizing health system service delivery for patients and their care givers.


Eligibility criteria: Inclusion Criteria:

* Outpatients of The Ottawa Hospital Respirology clinic
* Chronic Obstructive Pulmonary Disease diagnosis confirmed by pulmonary function testing.
* English or French speaking

Exclusion Criteria:

* patients with a known diagnosis of severe cognitive impairment

Primary outcomes:
measure: Respiratory Health Related Quality of Life
timeFrame: 12 months
Secondary outcomes:
measure: Burden of symptoms - COPD Assessment
timeFrame: 12 months
measure: Burden of symptoms - Dyspnea
timeFrame: 12 months
measure: Psycho-social well being - Anxiety
timeFrame: 12 months
measure: Psycho-social well being - Depression
timeFrame: 12 months
Other outcomes:
Locations:
city: Ottawa
country: Canada
facility: The Ottawa Hospital, General Campus
state: Ontario
Study officials:
References:
Clinical trial NCT03427541: A Study to Explore Prognoses of NSCLC Patients Complicated With Oligometastases
Official title: A Multi-centre Real-world Non-interventional Observational Study to Explore Prognoses of the Patients With Non-small Cell Lung Cancer Complicated With Oligometastases
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Non Small Cell Lung Cancer
Keywords: Chinese
non-small cell lung cancer
oligometastases
Lead sponsor: Tang-Du Hospital
Sponsor class: OTHER
Collaborators: name: LinkDoc Technology (Beijing) Co. Ltd.
First posted: 2018-02-09
Enrollment: 1000
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: RETROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Pathologically diagnosed patients with non-small cell lung cancer

Brief summary: An observational study to explore prognoses and clinical treatments of the patients with non-small cell lung cancer complicated with oligometastases

Detailed description: A multi-centre real-world non-interventional observational study to explore prognoses and clinical treatments of the patients with non-small lung cancer complicated with oligometastases

Eligibility criteria: Inclusion Criteria:

* Pathologically diagnosed patients with non-small cell lung cancer;
* Tumor metastases in one organ (no more than 3 metastases);

Exclusion Criteria:

* Patients with intrapulmonary metastases or multiple primary tumors;
* Patients with pleural dissemination or invasion of extrapulmonary organs;
* Patients with supraclavicular lymph node metastasis;
* Patients with systematic diseases that would influence patient survivals;
* Patients with no records for visits;

Primary outcomes:
measure: Overall survival
timeFrame: 2014 - 2017
Secondary outcomes:
measure: Disease-free survival
timeFrame: 2014 - 2017
Other outcomes:
Locations:
city: Beijing
country: China
facility: China-Japan Friendship Hospital
state: Beijing
city: Beijing
country: China
facility: China PLA General Hospital
state: Beijing
city: Zhengzhou
country: China
facility: Henan cancer hospital
state: Henan
city: Wuhan
country: China
facility: Tongji Hospital Affiliated to Huazhong Technology Hospital
state: Hubei
city: Nanjing
country: China
facility: Jiangsu cancer hospital
state: Jiangsu
city: Xi'an
country: China
facility: Xi'an Tangdu Hospital
state: Shaanxi
city: Shanghai
country: China
facility: Shanghai Chest Hospital
state: Shanghai
city: Chengdu
country: China
facility: Huaxi Hospital Affiliated to Sichuan University
state: Sichuan
city: Tianjin
country: China
facility: Tianjin Chest Hospital
state: Tianjin
city: Hangzhou
country: China
facility: First Hospital Affiliated to Zhejiang University
state: Zhejiang
Study officials:
References:
Clinical trial NCT06292741: Autonomic Involvement in Patient With Cognitive Decline
Official title: Evaluation of the Prevalence of Autonomic Nervous System Involvement in Patients With Cognitive Impairment by a Non-invasive Combined Study of Dysautonomia
Study type: INTERVENTIONAL
Overall status: RECRUITING
Phase: NA
Conditions: Dementia, Mild
Dementia of Alzheimer Type
Lead sponsor: Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Sponsor class: OTHER
First posted: 2024-03-05
Enrollment: 120
Sex: ALL
Minimum age (years): 50
Maximum age (years): 85
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: DIAGNOSTIC

Brief summary: Prospective interventional study with a device for comparing autonomic parameters among patients with different forms of cognitive decline


Eligibility criteria: Inclusion Criteria:

* male and females between 50 and 85 years
* cognitive decline (dementia, lewy's body dementia, Parkinson dementia, Alzheimer dementia)
* mild cognitive decline ( lewy's body MCI, Parkinson MCI and Alzheimer MCI)
* Ability to assume the upright position

Exclusion Criteria:

* diabetes mellitus
* eye problems
* severe cognitive decline
* heart disease
* peripheral neuropathy
* language barrier
* oncological disease
* medical pathologies associated with cognitive deficits

Primary outcomes:
measure: evaluation of the prevalence in autonomic dysfunction in patients with MCI and dementia
timeFrame: baseline through study completion, an average of 3 year
Secondary outcomes:
measure: correlation between the extent of autonomic involvement and the severity of cognitive decline
timeFrame: baseline through study completion, an average of 3 year
measure: evaluation of the type of cognitive disorder, defined by the scores obtained in the MMSE between subjects with and without autonomic dysfunction.
timeFrame: baseline through study completion, an average of 3 year
Other outcomes:
Locations:
city: Roma
country: Italy
facility: Clinica della memria- Fondazione Policlinico Agostino Gemelli IRCCS
state: Lazio
Study officials:
affiliation: Memory clinic- Policlinico Agostino Gemelli, IRCCS, Università Cattolica del Sacro Cuore I
name: Camillo Marra, MD
role: PRINCIPAL_INVESTIGATOR
References: