louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT00878358: Hydrotherapy Versus Physiotherapy for Short-term Rehabilitation After Primary TKR
Official title: Hydrotherapy Versus Physiotherapy for Short-term Rehabilitation After Primary TKR
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Osteoarthritis
Total Knee Replacement
Keywords: Osteoarthritis
Total knee replacement
Lead sponsor: Hadassah Medical Organization
Sponsor class: OTHER
First posted: 2009-04-08
Enrollment: 100
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: Primary objective:

To compare the effects of short term therapy post total knee replacement (TKR) between a hydrotherapy treatment group and a physiotherapy treatment group.

Secondary objectives:

To compare the effects of short term therapy post total knee replacement (TKR) between a hydrotherapy treatment group and a physiotherapy treatment group based on measurements of timed up and go (TUG, as primary outcome), range of motion, pain and quality of life.


Eligibility criteria: Inclusion Criteria:

* Candidates for first total knee replacement surgery.

  * Age over 18.
  * Diagnosed with Osteoarthritis.
  * Consent to participate in the trial.

Exclusion Criteria:

* - Rheumatic diseases.
* Neurological diseases involving lower limbs.
* Prior knee surgery in operated knee.
* Secreting surgical wound.
* Skin diseases.
* Incontinence.
* Incapable of signing informed consent.
* Patients living outside Jerusalem

Primary outcomes:
measure: Timed up and go test
timeFrame: 6 weeks
Secondary outcomes:
measure: Oxford knee score
timeFrame: 6 weeks
measure: Visual analogue pain score
timeFrame: 6 weeks
measure: Range of knee motion
timeFrame: 6 weeks
Other outcomes:
Locations:
city: Jerusalem
country: Israel
facility: Hadassah Medical Organization
Study officials:
References:
Clinical trial NCT06307158: Influence of Intraoperative Blood Salvage and Autotransfusion on Tumor Recurrence After Deceased Donor Liver Transplantation
Official title: Influence of Intraoperative Blood Salvage and Autotransfusion on Tumor Recurrence After Deceased Donor Liver Transplantation
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Liver Transplant; Complications
Lead sponsor: Zhejiang University
Sponsor class: OTHER
Collaborators: name: Shulan (Hangzhou) Hospital
First posted: 2024-03-12
Enrollment: 998
Sex: ALL
Minimum age (years): 18
Maximum age (years): 80
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: RETROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: A retrospective review was conducted on the prospectively maintained liver transplantation database of the CLTR. The initial data collection included patients who underwent adult-to-adult DDLT for HCC in China between January 2015 and December 2020.

Brief summary: The practice of intraoperative blood salvage and autotransfusion (IBSA) during deceased donor liver transplantation (DDLT) for hepatocellular carcinoma (HCC) can potentially reduce the need for allogeneic blood transfusion. However, implementing IBSA remains debatable due to concerns about its possible detrimental effects on oncologic recurrence. Hence, a nationwide multi-center study was conducted to investigate further the association between IBSA and post-transplant HCC recurrence, including a stratified subgroup analysis.


Eligibility criteria: Inclusion Criteria:

* adult-to-adult deceased donor liver transplantation for hepatocellular carcinoma

Exclusion Criteria:

* patients under 18 years of age
* presence of extrahepatic metastasis
* combined kidney transplantation
* reduced-size or split liver transplantation
* re-transplantation

Primary outcomes:
measure: Postoperative recurrence of liver cancer
timeFrame: 2015.1.1-2020.12.31
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
References:
Clinical trial NCT01870258: Myocardial Infarction Prediction
Official title: Prediction of Acute Myocardial Infarction With Artificial Neural Networks in Patients With Nondiagnostic Electrocardiogram
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Myocardial Infarction
Artificial Neural Network
Keywords: Myocardial infarction
artificial neural networks
Electrocardiography
Lead sponsor: Shiraz University of Medical Sciences
Sponsor class: OTHER
First posted: 2013-06-06
Enrollment: 1100
Sex: ALL
Minimum age (years): 40
Maximum age (years): 72
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NON_RANDOMIZED
Intervention model: PARALLEL
Primary purpose: DIAGNOSTIC

Brief summary: prediction of MI in patients with chest pain and nondiagnostic ECG was done in 2 weeks

Detailed description: Myocardial infarction remains one the leading causes of mortality and morbidity and involves a high cost of care. Early prediction can be helpful in preventing the development of myocardial infarction with appropriate diagnosis and treatment. Artificial neural networks have opened new horizons in learning about the natural history of diseases and predicting cardiac disease.

Methods: A total of 935 cardiac patients with chest pain and nondiagnostic electrocardiogram (ECG) were enrolled and followed for 2 weeks in two groups based on the appearance of myocardial infarction. Two types of data were used for all patients: nominal (clinical data) and quantitative (ECG findings). Two different artificial neural networks - radial basis function (RBF) and multi-layer perceptron (MLP) - were used.

Eligibility criteria: Inclusion Criteria:

* patient with chest pain refered to ER with nondiagnostic ECG

Exclusion Criteria:

* 1) Absence of a history of myocardial infarction
* 2) Absence of bundle branch block, Wolf-Parkinson-White abnormality, ventricular hypertrophy or previous ECG signs of myocardial infarction,
* 3) Absence of a history of percutaneous coronary surgery or coronary artery bypass grafting,
* 4) Absence of ECG abnormalities attributable to drugs such as digoxin or tricyclic antidepressants.

Primary outcomes:
measure: myocardial infarction
timeFrame: 2 weeks
Secondary outcomes:
measure: hospital admission due to cardiac events
timeFrame: 2 weeks
Other outcomes:
Locations:
Study officials:
References:
Clinical trial NCT04041258: "Evaluation of Clinical and Radiographic Results of Pseudarthrosis of Clavicle Treated With Plaque and Screws"
Official title: "Evaluation of Clinical and Radiographic Results of Pseudarthrosis of Clavicle Treated With Plaque and Screws"
Study type: INTERVENTIONAL
Overall status: TERMINATED
Phase: NA
Conditions: Pseudoarthrosis of the Clavicle
Keywords: pseudoarthrosis
clavicle
Lead sponsor: Istituto Ortopedico Rizzoli
Sponsor class: OTHER
First posted: 2019-08-01
Enrollment: 20
Sex: ALL
Minimum age (years): 18
Maximum age (years): 65
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Intervention model description: interventional study
Primary purpose: TREATMENT

Brief summary: This is an interventional study for clinical and radiographic evaluation of patients operated for pseudoarthrosis of the clavicle

Detailed description: The aim of our study is to collect clinical and radiographic data from patients operated for pseudoarthrosis of the clavicle from 2007 to 2017 at the Rizzoli Orthopedic Institute, in order to evaluate the clinical and radiographic results of the treatment. This is an interventional study and patients will be contacted by telephone to verify their willingness to perform a visit (including a bilateral radiographic) at the Rizzoli Orthopedic Institute

Eligibility criteria: Inclusion Criteria:

1. 18-65 years of pseudarthrosis intervention
2. Males and Females
3. Patients treated for pseudoarthrosis of the clavicle between 2007 and 2017 at the Rizzoli Orthopedic Institute

Exclusion Criteria:

1. Floating shoulder
2. subjects who present contraindications to radiographic examination at the time of telephone contact

Primary outcomes:
measure: range of motion ROM
timeFrame: at least 1 year of follow up
measure: presence of dyskinesias
timeFrame: at least 1 year of follow up
measure: alteration of the clavicle length
timeFrame: at least 1 year of follow up
Secondary outcomes:
measure: evaluate shoulder function
timeFrame: at least 1 year of follow up
Other outcomes:
Locations:
city: Bologna
country: Italy
facility: Rizzoli Orthopaedic Institute
Study officials:
References:
Clinical trial NCT00747058: A Study To Investigate The Safety, Toleration And Pharmacokinetics Of Single Oral Doses Of PF-03864086 In Healthy Male Subjects
Official title: A Double Blind (3rd Party Open), Randomized, Placebo Controlled, Dose Escalating Study To Investigate The Safety, Toleration And Pharmacokinetics Of Single Oral Doses Of PF-03864086 In Healthy Male Subjects
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE1
Conditions: Pain
Keywords: phase 1, human study, healthy volunteers
Lead sponsor: Pfizer
Sponsor class: INDUSTRY
First posted: 2008-09-04
Enrollment: 28
Sex: MALE
Minimum age (years): 21
Maximum age (years): 55
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: CROSSOVER
Primary purpose: TREATMENT

Brief summary: The purpose of this study is to determine the safety and tolerability of PF-03864086 in healthy male human volunteers. Determine the pharmacokinetics (calculations of the rate of elimination of PF-03864086 from the body once the compound is ingested).


Eligibility criteria: Inclusion Criteria:

* healthy male volunteers
* no drug history
* no other medication for 28 pre-dose

Exclusion Criteria:

* age below 21 years
* age above 55 years

Primary outcomes:
measure: Pharmacokinetics
timeFrame: measured intensively in the first 48 hours and continue out to day 14
measure: Tolerability
timeFrame: measured intensively in the first 48 hours and continue out to day 14
Secondary outcomes:
measure: Temperature change
timeFrame: continuous recording over the first 48h post dose
Other outcomes:
Locations:
city: Bruxelles
country: Belgium
facility: Pfizer Investigational Site
Study officials:
affiliation: Pfizer
name: Pfizer CT.gov Call Center
role: STUDY_DIRECTOR
References:
Clinical trial NCT01738958: Effect of Lozenges Containing Probiotic Lactobacilli on Enamel Demineralization Assed by QLF
Official title: Effect of Lozenges Containing Probiotic Lactobacilli on Enamel Demineralization Assed by QLF
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Caries Dentalis
Keywords: Probiotic bacteria
Caries dentalis
QLF
Lead sponsor: University of Copenhagen
Sponsor class: OTHER
First posted: 2012-11-30
Enrollment: 66
Sex: ALL
Minimum age (years): 12
Maximum age (years): 17
Standard ages: CHILD
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: PREVENTION

Brief summary: Clinical trials in children and adults have suggested that daily consumption of probiotic lactic acid bacteria can reduce caries risk and caries development in primary teeth in preschool and stop root caries in the elderly. However, it is not known whether probiotic bacteria can affect the increased porosity in young permanent teeth in children and adolescents with many cavities.

It can be difficult to measure the increased porosity of the enamel by tooth decay, but this can be done using quantitative laser fluorescence (QLF). The method is based on visible light with a wavelength of 370 nm, addressing enamel. This produces an image consisting of red and green color tones and the dominant color of the enamel is green. Increased porosity of the enamel, resulting in a reduction of the auto-fluorescence and the loss (or gain) of the mineral can be quantified by means of a corresponding software.

The purpose of this study is to investigate the effect of a daily supplement of probiotic lactic acid bacteria on the loss of mineral in enamel assessed with QLF. The null hypothesis is that the mineral content will not differ from baseline in either the test group or the placebo group.


Eligibility criteria: Inclusion Criteria:

* two sites with white spot lesions in anterior teeth

Exclusion Criteria:

* antibiotic treatment within 2 months

Primary outcomes:
measure: Change in enamel porosity
timeFrame: Baseine and 12 weeks
Secondary outcomes:
Other outcomes:
Locations:
city: Ishøj
country: Denmark
facility: Ishøj kommunale tandpleje
Study officials:
References:
Clinical trial NCT02873858: Elucidation of Sensory Characteristics and Food Preferences in the Elderly
Official title: Elucidation of Sensory Characteristics and Food Preferences in the Elderly
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Malnutrition
Keywords: elderly
Lead sponsor: Centre Hospitalier Universitaire Dijon
Sponsor class: OTHER
First posted: 2016-08-22
Enrollment: 611
Sex: ALL
Minimum age (years): 65
Standard ages: OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NON_RANDOMIZED
Intervention model: PARALLEL

Brief summary: Malnutrition is a frequent problem in persons older than 65 years: the prevalence of malnutrition can reach 25 to 29% in persons living at home who require help, figures vary between 19 and 38% for those living in institutions, and finally, the prevalence of malnutrition in hospitalized elderly patients can reach 30 to 90%. A few studies have attempted to explain modifications in attitudes, behaviour, the frequency of meals or nutritional status in the elderly by a fall in chemosensory sensitivity The aim of this project is to test the hypothesis that perhaps it is not as much the capacity to perceive a smell or a taste that affects eating behaviour in the elderly as their ability to distinguish between smells or tastes on the one hand (perceptual processing), and their ability to correctly interpret a chemosensory signal on the other (cognitive processing).


Eligibility criteria: Inclusion Criteria:

* Persons older than 65 years.
* Persons with diabetes, heart disease or hypertension stabilized by a treatment.
* Persons cognitively able to carry out the tests and fill in the questionnaires (Folstein test between 22 and 30).

Exclusion Criteria:

* Any person suffering from an acute disease at the time of the test.
* Any person presenting any allergy whatsoever (food, mites, pollen...).
* Any person suffering from asthma or severe respiratory disorders (lung cancer, tracheotomy...).
* Any person presenting anosmia (total loss of olfaction) from birth or following physical trauma (head injury) or due to disease (severe rhinitis).
* Persons with diabetes, heart disease or hypertension not stabilized by treatment.
* Any person presenting life expectancy of less than 6 months.

Primary outcomes:
measure: Indeed the level of dependency of scores at each of the olfactory tests, gustatory and masticatory
timeFrame: Day 1
Secondary outcomes:
Other outcomes:
Locations:
city: Dijon
country: France
facility: CHU Dijon Bourgogne
Study officials:
References:
Clinical trial NCT04637958: Correlation Between Femoral Head and Cup Size and Postoperative Pain in Total Hip Arthroplasty
Official title: Correlation Between Femoral Head and Cup Size and Postoperative Pain in Total Hip Arthroplasty
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Femoral Head Size
Cup Size THP
Postoperatie Groin Pain
Lead sponsor: Universitaire Ziekenhuizen KU Leuven
Sponsor class: OTHER
First posted: 2020-11-20
Enrollment: 463
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: RETROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: retrospective database THA

Brief summary: We want to investigate the correlation between the native femoral head and the implanted cup in Total hip arthroplasty. As second parameter to investigate we believe an oversized cup will cause groin pain. We want to find a cutoff value to predict groin pain after cup implementation in THA.


Eligibility criteria: Inclusion Criteria:

* all primary THA

Exclusion Criteria:

* DDH-LCP
* Acetabulum/femoral neck fracture

Primary outcomes:
measure: Correlation between femoral head and cup size and postoperative pain in Total Hip arthroplasty
timeFrame: 1 year
Secondary outcomes:
Other outcomes:
Locations:
city: Leuven
country: Belgium
facility: UZ Leuven
Study officials:
References:
citation: Odri GA, Padiolleau GB, Gouin FT. Oversized cups as a major risk factor of postoperative pain after total hip arthroplasty. J Arthroplasty. 2014 Apr;29(4):753-6. doi: 10.1016/j.arth.2013.07.001. Epub 2013 Aug 6.
Clinical trial NCT03731858: HbA1c in Intracytoplasmic Sperm Injection
Official title: Role of HbA1c in Intracytoplasmic Sperm Injection
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Infertility
Lead sponsor: Aljazeera Hospital
Sponsor class: OTHER
First posted: 2018-11-06
Enrollment: 400
Sex: FEMALE
Minimum age (years): 20
Maximum age (years): 42
Standard ages: ADULT
Accepts healthy volunteers: yes
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: -Any lady with infertilty and has a recurrent ICSI trials

Brief summary: ICSI has increased nowadays for treating cases of longstanding infertility . HbA1c has an important value in evaluating glucose level in blood

Detailed description: - The level of HbA1c in blood denotesnthe glycemic control over the past 3 months . Its regulation is very important in human reproductive life

Eligibility criteria: Inclusion Criteria:

* females with infertility from 20 to 42 years old

Exclusion Criteria:

* females with age below 20 or above 42 years

Primary outcomes:
measure: the number of ladies who will get pregnant
timeFrame: within one year
Secondary outcomes:
Other outcomes:
Locations:
city: Giza
country: Egypt
facility: Algazeerah and Kasralainy hospital
Study officials:
affiliation: Algazeerah hospital -Location (Giza -Egypt ) and National Research centre egypt
name: Mahmoud Alalfy, PhD
role: STUDY_CHAIR
References:
Clinical trial NCT03777358: Three-dimensional Ultrasonography Versus Hysteroscopy in Evaluation of Uterine Cavity in Infertile Women
Official title: A Prospective Study Comparing Three-dimensional Ultrasonography Versus Hysteroscopy in Evaluation of Uterine Cavity in Infertile Women
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Female Infertility
Lead sponsor: Mansoura University
Sponsor class: OTHER
First posted: 2018-12-17
Enrollment: 300
Sex: FEMALE
Minimum age (years): 18
Maximum age (years): 40
Standard ages: ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: Infertile women (primary or secondary) aged between 18 and 40 years.

Brief summary: Hysteroscopy has now become a gold-standard technique carried out for uterine cavity assessment in infertile women. Apart from direct visualizing of the endometrium by the naked eye, pathologies missed by other modalities of investigation can be picked up and managed appropriately. Unfortunately, the procedure itself is not free from complications e.g. perforation, cervical laceration, bleeding, limited access in cases of cervical stenosis and considered as an invasive procedure.

Two-dimensional transvaginal ultrasonography (2D-TVS)and Three-dimensional TVS (3D-TVS) are non-invasive methods for evaluating the uterine cavity. The3D-TVS is superior to 2D-TVS in identifying uterine cavity abnormalities due to its ability to obtain a view of three different planes of the uterus, which could be used to locate the position of intracavitary pathology. Reports vary regarding the diagnostic accuracy of 3D-TVS that was reported to have 41.3-81.5% sensitivity and 94.6-98.7% specificity. So it became clear that 3D-TVS is a non-invasive and safe diagnostic tool for evaluation of the uterine cavity abnormalities but its sensitivity, specificity and accuracy still a matter of debate and warrants more evaluation.


Eligibility criteria: Inclusion Criteria:

* Infertile women (primary or secondary)
* Age between 18 and 40 years.

Exclusion Criteria:

* age\<18 years and˃ 40 years.
* pelvic inflammatory disease.
* .Active uterine bleeding

Primary outcomes:
measure: Diagnostic accuracy of 3D-TVS
timeFrame: At 1 week postmenstrual
Secondary outcomes:
Other outcomes:
Locations:
city: Mansourah
country: Egypt
facility: Mansoura University Hospitals
state: Dakahlia Governorate
Study officials:
affiliation: Faculty of Medicine, Mansoura University
name: Hatem Abu Hashim, MD. FRCOG. PhD
role: STUDY_CHAIR
affiliation: Faculty of Medicine, Mansoura University
name: Mohamed Fekry, MSc
role: PRINCIPAL_INVESTIGATOR
References:
citation: Ahmadi F, Rashidy Z, Haghighi H, Akhoond M, Niknejadi M, Hemat M, Shamsipour M. Uterine cavity assessment in infertile women: Sensitivity and specificity of three-dimensional Hysterosonography versus Hysteroscopy. Iran J Reprod Med. 2013 Dec;11(12):977-82.
Clinical trial NCT01283958: The Effects of Inhaled Iloprost on Congenital Heart Disease With Eisenmenger Syndrome
Official title: Study of the Effects of Inhaled Iloprost on Congenital Heart Disease With Eisenmenger Syndrome
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Eisenmenger's Syndrome
Keywords: Iloprost, Eisenmenger's syndrome
Lead sponsor: Gachon University Gil Medical Center
Sponsor class: OTHER
First posted: 2011-01-26
Enrollment: 12
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: CASE_ONLY
Time perspective: RETROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: 12 patients with Eisenmenger's syndrome diagnosed by right side cardiac catheterization

Brief summary: Identification of the pathophysiology associated with Eisenmenger's syndrome has led to the evaluation of targeted therapies. Iloprost, a prostacyclin analogue, is one such targeted therapy used in patients with Eisenmenger's syndrome. The purpose of our study is to assess the effects of inhaled iloprost on patients with Eisenmenger's syndrome.


Eligibility criteria: Inclusion Criteria:

* patients with Eisenmenger's syndrome diagnosed by right side cardiac catheterization

Exclusion Criteria:

Primary outcomes:
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
References: