louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT06719518: Performance Evaluation of the ViTrack Continuous Non-invasive Blood Pressure Measurement Device
Official title: Performance Evaluation of the ViTrack Continuous Non-invasive Blood Pressure Measurement Device
Study type: OBSERVATIONAL
Overall status: NOT_YET_RECRUITING
Conditions: Blood Pressure
Keywords: ViTrack
blood pressure monitoring
Lead sponsor: The University of Texas Health Science Center, Houston
Sponsor class: OTHER
First posted: 2024-12-05
Enrollment: 40
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: subjects scheduled to undergo noncardiac surgery with likely invasive arterial pressure monitoring will be included will be included

Brief summary: The purpose of this study is to calibrate the ViTrack™ arterial pressure waveform against intra-arterial pressure (IAP) in dynamic clinical settings and to assess the optimized ViTrack™ design to measure and continuously track blood pressure over a wide, clinically-relevant pressure range.


Eligibility criteria: Inclusion Criteria:

* scheduled to undergo noncardiac surgery with general or spinal anesthesia
* clinical indication for invasive intra-arterial pressure monitoring
* palpable pulse

Exclusion Criteria:

* difference of greater than 10 mmHg in the left versus right arm oscillometric systolic blood pressure
* Upper extremity arteriovenous hemodialysis shunt
* Upper extremity amputation
* Planned surgical position/draping that precludes access to the wrist
* Wrist distortion or pain from arthritis
* Prior trauma or surgery at the radial artery monitoring site
* Unable to provide informed consent
* Clinical contraindication as determined by the clinical team or study investigators

Primary outcomes:
measure: Comparison of Diastolic Blood Pressure
timeFrame: From start of surgery up to 24 hours after surgery
measure: Comparison of Systolic Blood Pressure
timeFrame: From start of surgery up to 24 hours after surgery
Secondary outcomes:
measure: Number of participants who show signs of Skin Irritation
timeFrame: From start of surgery up to 72 hours after surgery
Other outcomes:
Locations:
city: Houston
country: United States
facility: The University of Texas Health Science Center at Houston
state: Texas
Study officials:
affiliation: The University of Texas Health Science Center, Houston
name: Mehmet Turan, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT02091518: Development and Evaluation of Magnetic Resonance Imaging Acquisition and Analysis Methods
Official title: Development and Evaluation of Magnetic Resonance Imaging Acquisition and Analysis Methods
Study type: INTERVENTIONAL
Overall status: ENROLLING_BY_INVITATION
Phase: NA
Conditions: Healthy
Keywords: MRI
13-239
volunteers
patients
Lead sponsor: Memorial Sloan Kettering Cancer Center
Sponsor class: OTHER
Collaborators: name: Ceretype
name: University of California, San Diego
First posted: 2014-03-19
Enrollment: 461
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: DIAGNOSTIC

Brief summary: Magnetic resonance imaging (MRI) is a diagnostic imaging method with constant progress and improvement in the way the MRI images are obtained. Many of these advances involve changes to MRI software and hardware. The goal of this study is to find out the possible benefits of new MRI techniques. This will allow us to use the new MRI methods in research and patient care.


Eligibility criteria: Inclusion Criteria:

* Men and women age 18 or older

Exclusion Criteria:

* Anyone who would be normally excluded from undergoing an MRI examination as per Memorial Hospital for Cancer and Allied Diseases Screening Questionnaire for MRI
* Patients/volunteers with a pacemaker, aneurysm clip or any other condition that would warrant avoidance of a strong magnetic field
* Female patients/ volunteers who are pregnant or nursing
* Patients/ volunteers who are unable to comply or complete the MRI exam due to claustrophobia or high levels of anxiety
* Patients/ volunteers from the vulnerable population, as defined by 45 CFR 46.
* Patients at higher risk due to age, frailty, or the emergent nature of their condition

Primary outcomes:
measure: feasibility of new MRI applications
timeFrame: 5 years
Secondary outcomes:
Other outcomes:
Locations:
city: New York
country: United States
facility: Memorial Sloan Kettering Cancer Center
state: New York
Study officials:
affiliation: Memorial Sloan Kettering Cancer Center
name: Oguz Akin, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT02549118: Tenoxicam for Intrapartum Analgesia
Official title: Efficacy of Intravenous Tenoxicam as an Analgesic During the First Stage of Labor: A Randomized Controlled Trial
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: PHASE2
Conditions: Analgesia
Obstetrical
Lead sponsor: Ain Shams Maternity Hospital
Sponsor class: OTHER
First posted: 2015-09-15
Enrollment: 100
Sex: FEMALE
Minimum age (years): 20
Maximum age (years): 30
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The aim of this study is to assess whether tenoxicam is as effective as pethidine for analgesia during the first stage of labor.


Eligibility criteria: Inclusion Criteria:

* Primiparity
* Active phase of labor (cervical dilatation of 3-5 cm, in the presence of adequate uterine contractions; lasting at least 40 seconds at intervals of 3-4 minutes)
* Maternal age between 20-30 years
* Singleton term pregnancy (37-42 weeks of gestation)
* Vertex-presenting fetus

Exclusion Criteria:

* Clinical evidence of cephalopelvic disproportion
* Scarred uterus; previous cesarean section, hysterotomy or myomectomy
* Medical disorders associated with pregnancy, especially gastritis, peptic ulcer, bronchial asthma or renal impairment
* Fetal distress
* Receiving any regional or parenteral analgesia before recruitment in the study
* Known hypersensitivity to the drug family

Primary outcomes:
measure: The efficacy of intravenous tenoxicam to supply adequate analgesia as indicated by changes in the pain intensity score using the visual analog scale
timeFrame: 4 hours
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
References:
Clinical trial NCT05910918: Intensive Care Nurses' Training Package on the Safety Culture of Geriatric Patients
Official title: Effect of Intensive Care Nurses' Training Package on the Safety Culture of Critically Ill Geriatric Patients:Findings and Implications for Clinical Practice
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Safety
Keywords: Geriatric Patients
Critically ill
Lead sponsor: Alexandria University
Sponsor class: OTHER
First posted: 2023-06-20
Enrollment: 60
Sex: ALL
Minimum age (years): 20
Maximum age (years): 30
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: NON_RANDOMIZED
Intervention model: PARALLEL
Primary purpose: SUPPORTIVE_CARE

Brief summary: This study aims to determine the effect of intensive care nurses' training package on the safety culture of critically ill geriatric patients.

Study hypothesis:

Intensive care nurses who receive the proposed training package exhibit higher scores on critically ill geriatric patients' safety culture awareness than those who do not receive it.

Detailed description: The researchers will prepare the proposed nurses' training package program. The program will be planned to be carried out in 10 sessions that will be classified into; sessions regarding knowledge about the age-related changes affecting elderly patients that should be considered while caring for them and how to care for and maintain the safety of the critically ill geriatric patients. The researchers will prepare an illustrative PowerPoint presentation of each study program's session.

Eligibility criteria: Inclusion Criteria:

* aged 20 years and above.
* provide direct care for critically ill geriatric patients.
* work for at least 1 month in the unit.

Exclusion Criteria:

• not involved in patient care.

Primary outcomes:
measure: Intensive Care Nurses' Awareness of the Critically Ill Geriatric Patients' Safety Culture Questionnaire
timeFrame: 2 weeks
Secondary outcomes:
Other outcomes:
Locations:
city: Alexandria
country: Egypt
facility: Rasha Eweida
city: Alexandria
country: Egypt
facility: Faculty of Nursing
Study officials:
affiliation: Egypt Faculty of Nursing Alexandria, Egypt
name: Eman Taha
role: STUDY_CHAIR
References:
citation: Nguyen YL, Angus DC, Boumendil A, Guidet B. The challenge of admitting the very elderly to intensive care. Ann Intensive Care. 2011 Aug 1;1(1):29. doi: 10.1186/2110-5820-1-29.
citation: Laake JH, Dybwik K, Flaatten HK, Fonneland IL, Kvale R, Strand K. Impact of the post-World War II generation on intensive care needs in Norway. Acta Anaesthesiol Scand. 2010 Apr;54(4):479-84. doi: 10.1111/j.1399-6576.2009.02170.x. Epub 2009 Nov 23.
citation: Bagshaw SM, Webb SA, Delaney A, George C, Pilcher D, Hart GK, Bellomo R. Very old patients admitted to intensive care in Australia and New Zealand: a multi-centre cohort analysis. Crit Care. 2009;13(2):R45. doi: 10.1186/cc7768. Epub 2009 Apr 1.
citation: Boumendil A, Somme D, Garrouste-Orgeas M, Guidet B. Should elderly patients be admitted to the intensive care unit? Intensive Care Med. 2007 Jul;33(7):1252. doi: 10.1007/s00134-007-0621-3. Epub 2007 Apr 3.
Clinical trial NCT04227418: An Evaluation of the Safety and Clinical Utility of Handheld ECG Technology in Psychiatry
Official title: An Evaluation of the Safety and Clinical Utility of Handheld ECG Technology in Psychiatry
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Cardiovascular Diseases
Dementia
Mental Health Disorder
Lead sponsor: The Leeds Teaching Hospitals NHS Trust
Sponsor class: OTHER
Collaborators: name: Leeds and York Partnership NHS Foundation Trust
First posted: 2020-01-13
Enrollment: 1500
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: All adults, 18 and over, attending memory clinic with a new diagnosis of Alzheimer's, Mixed or Lewy Body type dementia indicated for AChIE treatment, will be invited to participate. These are patients who would be indicated to have an ECG as part of routine practice.

All general adult and old age inpatient wards in Leeds and York Partnership NHS Foundation Trust.

Brief summary: Acetylcholinesterase inhibitors and antipsychotics are drugs commonly prescribed in psychiatry, the former for dementia and the latter for acute and chronic psychotic illness. Both can cause cardiac arrhythmia therefore 12 lead ECG's are recommended before prescribing. The test is often difficult to obtain however, leading to either patients being inconvenienced or drugs prescribed without the test. There are two parts of this study, but both examine the utility of single lead ecg monitoring, one in the memory clinic and the other in inpatient psychiatry wards. The aim to to evaluate the safety and efficacy of the handheld ecg versus the 12 lead and 6 lead ecg, and whether the handheld ecg can be used to screen for ecg abnormalities that would generally lead to a caution or contra-indication for acetylcholinesterase inhibitors and anti-psychotic medication.

Patients will either be recruited from the outpatient memory clinic or in patient psychiatry wards. Following informed consent baseline demographic data will be collected, and patients will undergo a 12 lead and 6 lead ECG as well as a rhythm strip using the handheld device. Data from this point will be annonymised for future analysis. The psychiatrists ECG report will also be recorded, and a subset of patients will undergo an echocardiogram (to see what proportion of patients with psychiatric disorders have structural heart disease.)


Eligibility criteria: Inclusion Criteria:

Any patient attending the memory clinic Any patient admitted to the acute psychiatric ward requiring antipsychotic medication

Exclusion Criteria:

Patients who lack capacity and do not have a personal consultee to provide assent

Primary outcomes:
measure: ECG monitoring
timeFrame: 45 minutes
Secondary outcomes:
Other outcomes:
Locations:
city: Leeds
country: United Kingdom
facility: Leeds Partnership NHS Foundation Trust
state: West Yorkshire
Study officials:
References:
Clinical trial NCT01452841: A Grapefruit Feeding Trial in Healthy, Overweight Adults
Official title: Efficiency of Daily Grapefruit Exposure in Reducing Body Weight and Inflammatory Markers
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Weight Loss
Obesity
Cardiovascular Risk Factors
Keywords: grapefruit
weight loss
blood pressure
lipids
inflammation
Lead sponsor: University of Arizona
Sponsor class: OTHER
Collaborators: name: Texas A&M University
First posted: 2011-10-17
Enrollment: 85
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: SINGLE_GROUP
Primary purpose: PREVENTION

Brief summary: Folklore has suggested that consuming grapefruit may promote weight control. Sparse data exist to support this hypothesis, though there is some evidence of health promotional effects regarding blood pressure and lipid profiles. The aims of this randomized controlled trial are to determine the role of grapefruit in:

1. Reducing weight
2. Reducing blood pressure
3. Reducing inflammation
4. Improving the lipid profile.

The investigators hypothesize that six weeks of daily consumption of grapefruit will reduce weight, blood pressure, and inflammation while improving the lipid profile in overweight, healthy adults.


Eligibility criteria: Inclusion Criteria:

* Adults, men and premenopausal women
* BMI: 25-45 kg/m2
* Willing to maintain current exercise regimen (not to exceed 10 hours/week)
* Willing to follow a diet low in bioactive rich fruits and vegetables and with no citrus

Exclusion Criteria:

* History of chronic disease
* Metabolic disease
* Inflammatory disease
* High cholesterol (\>225 mg/dL)
* Smoker
* Taking medications metabolized by the Cytochrome P450 3A enzyme
* History of alcohol or drug abuse

Primary outcomes:
measure: Weight reduction
timeFrame: 6 weeks
Secondary outcomes:
measure: Blood pressure reduction
timeFrame: 6 weeks
measure: Lipid Profile Improvements
timeFrame: 6 weeks
measure: Reductions in markers of chronic inflammation
timeFrame: 6 weeks
Other outcomes:
Locations:
city: Tucson
country: United States
facility: University of Arizona
state: Arizona
Study officials:
affiliation: University of Arizona
name: Cynthia Thomson, PhD, RD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT04259541: Selected Aspects of Mental Health of Athletes
Official title: Selected Aspects of Mental Health of Athletes
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Mental Health Disorder
Lead sponsor: University of Primorska
Sponsor class: OTHER
First posted: 2020-02-06
Enrollment: 360
Sex: ALL
Minimum age (years): 18
Maximum age (years): 40
Standard ages: ADULT
Accepts healthy volunteers: yes
Observational model: COHORT
Time perspective: CROSS_SECTIONAL
Sampling method: PROBABILITY_SAMPLE
Study population: Atletes at a competitive level, coming from different sports.

Brief summary: The study will assess the prevalence of mental health problems among different athletes. The study is based on the application of the battery of psychodiagnostic questionnaires, which were chosen aiming at investigating the prevalence of different symptoms related to problems in mental health or disorders.

This descriptive cross-sectional study will undertake sample with athletes categorized by the quality of their achievement.

Detailed description: In the field of sports, there is a lot of knowledge about sports injuries, nutrition and regeneration. Much less is known about mental health among athletes. The investigators often think that the incidence of mental problems is low among top athletes. As the main cause of this misconception, the authors attribute the idealization of sports and athletes. Both the professional and the lay public are often of the opinion that only mentally strong individuals can be successful, which of course means that there is no place in the highest level for individuals with mental problems and disorders.

The clinical study will be performed with 400-500 athletes of both genders aged 18 to 40, from Slovenia. The investigators will invite all athletes who have been categorized in the current year and classified into the membership category, i.e. national, international, world or Olympic class (there were 500 at the last categorization) and they compete in various sports disciplines. The study will be designed as a cross-sectional study. For the purpose of the research, the investigators will use a battery of psychodiagnostic questionnaires consisting of five parts: demographics and sport characteristic, depression symptomatic, anxiety symptomatic, eating problems, alcohol use and abuse and resilience characteristics of individual athlete.

Eligibility criteria: Inclusion Criteria:

* Included in competitive play
* Is a professional athlete or participates in organized professional sports activities

Exclusion Criteria:

* Present injuries
* Recreational athletes
* Any other significant diseases

Primary outcomes:
measure: Intensity and frequency of specific symptoms
timeFrame: Baseline
Secondary outcomes:
measure: Depressive symptomatology
timeFrame: Baseline
measure: Pathological eating patterns
timeFrame: Baseline
measure: Level of risky alcohol consumption
timeFrame: Baseline
measure: Resilience
timeFrame: Baseline
Other outcomes:
Locations:
city: Izola
country: Slovenia
facility: University of Primorska, Faculty of health care
Study officials:
References:
Clinical trial NCT04541641: Clinical Evaluation of Stability of Implants Placed in Partially Edentulous Maxilla With Poor Bone Quality Via New Reverse Drilling Technique Versus Osteotome Technique.
Official title: Clinical Evaluation of Stability of Implants Placed in Partially Edentulous Maxilla With Poor Bone Quality Via New Reverse Drilling Technique Versus Osteotome Technique: A Randomized Controlled Clinical Trial
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Dental Implant
Lead sponsor: Cairo University
Sponsor class: OTHER
First posted: 2020-09-09
Enrollment: 28
Sex: ALL
Minimum age (years): 21
Maximum age (years): 50
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The study will compare between osteotome technique and New Reverse Drilling Technique in the placement of dental implant in posterior maxilla , primary outcome will be Implant stability that will be measured by Periotest device . follow up for 6 month.

secondary outcomes will be crestal bone loss , pain and swelling.


Eligibility criteria: Inclusion criteria:

1. Partially edentulous patients in the maxillary posterior region.
2. Systemically healthy patient.
3. Presence of proper inter-arch space for placement of the implant prosthetic part.
4. Sufficient bone height and width for implant placement (bone height ≥10mm and bone width ≥6mm).
5. Non-smoker.
6. Patients who are ≥ 20 years old.
7. Good oral hygiene.
8. Acceptance of a one year follow-up period.
9. Informed consent is provided by the patient.

Exclusion criteria:

1. Patients with systemic conditions that may interfere with implant stability,
2. Patients with local pathological defects related to the area of interest.
3. Unmotivated, uncooperative patients with poor oral hygiene.
4. Patients with habits that may jeopardize the implant longevity and affect the results of the study such as alcoholism or parafunctional habits.
5. Inadequate inter-arch space for implant prosthetic part

Primary outcomes:
measure: implant stability
timeFrame: 6 months
Secondary outcomes:
measure: crestal bone loss
timeFrame: 6 monthz
Other outcomes:
Locations:
Study officials:
References:
Clinical trial NCT05069441: Prediction of Extubation Failure: A Multicenter Prospective Observational Study
Official title: The First Affiliated Hospital of Chongqing Medical University
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Mechanical Ventilation
Keywords: Extubation Failure
Lead sponsor: Chongqing Medical University
Sponsor class: OTHER
First posted: 2021-10-06
Enrollment: 2604
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: CASE_ONLY
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: The population is that the patients who passed a spontaneous breathing trial and readiness for extubation.

Brief summary: The investigators intend to collect several variables to predict extubation failure among patients who successfully complete a spontaneous breathing trial, and then develop a scale using simple bedside indicators to predict extubation failure.

Detailed description: Mechanically ventilated patients who successfully completed a spontaneous breathing trial and prepared for extubation are eligible to enroll in this study. The vital signs, arterial blood gas tests, cough strength, cuff leak test, use of noninvasive ventilation et al. are collected. Patients are followed up to postextubation 28-day or discharge. Extubation failure is defined as reintubatin or death within postextubation 7 days. First, we will analyze the data to predict extubation failure. Then, we will combine several easily obtained variables to develop and validate a scale to predict extubation failure. Finally, we explore the predictive power of extubation failure tested by the scale and find the cutoff value to distinguish the low, moderate and high risk of extubation failure.

Eligibility criteria: Inclusion Criteria:

* Prepared for extubation through spontaneous breathing trial;Oral or nasal endotracheal intubation; be at least 18 years old

Exclusion Criteria:

* Extubation without a spontaneous breathing trial ;Reintubation due to secondary surgery; Tracheotomy

Primary outcomes:
measure: Rate of extubation failure
timeFrame: From extubation to 48 hours
measure: Rate of extubation failure
timeFrame: From extubation to 7 days
measure: Rate of extubation failure
timeFrame: From extubation to 28 days
Secondary outcomes:
measure: Rate of mortality
timeFrame: From extubation to 28 days
measure: ICU stay
timeFrame: From extubation to 28 days
Other outcomes:
Locations:
city: Chongqing
country: China
facility: The First Affiliated Hospital of Chongqing Medical University
Study officials:
affiliation: First Affiliated Hospital of Chongqing Medical University
name: Jun Duan
role: PRINCIPAL_INVESTIGATOR
References: