Clinical trial NCT06967766: A Complex Intervention to Promote Appropriate Antibiotic Use Among Rural Residents Based on the Metaphor-Embedded Integrated Behavioral Model
Official title: A Complex Intervention to Promote Appropriate Antibiotic Use Among Rural Residents Based on the Metaphor-Embedded Integrated Behavioral Model
Study type: INTERVENTIONAL
Overall status: NOT_YET_RECRUITING
Phase: NA
Conditions: Antimicrobial Drug Resistance
Keywords: health education
Metaphor
Lead sponsor: Zhejiang University
Sponsor class: OTHER
First posted: 2025-05-13
Enrollment: 1500
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: NON_RANDOMIZED
Intervention model: PARALLEL
Primary purpose: HEALTH_SERVICES_RESEARCH

Brief summary: The study aims to address the question of how to provide effective health education on health topics with high medical specialisation (e.g. bacterial drug resistance in this study), especially for rural or low-educated populations. In response to the high degree of correlation between irrational antimicrobial drug use behaviours, how to achieve the effectiveness of interventions on the complex health topic of rational use of antimicrobial drugs through synergistic interventions with multiple scenarios?

In this study, the investigators used an experimental-like research design to conduct a full-scenario intervention involving antimicrobial drug acquisition, use, and disposal in a township-based approach, so as to reduce the prevalence of irrational antimicrobial drug use behaviours among rural residents, and to significantly improve the governance of antimicrobial drug use in rural areas. After six months of intervention, the following specific objectives were achieved:

1. The incidence of self-treatment and use of antimicrobial drugs in the intervention group decreased by 30% compared with the control group;
2. Rational use of antimicrobial drugs and awareness of bacterial drug resistance among rural residents in the intervention group increased by 50% compared with the control group;
3. In the intervention group, the incidence of rural residents actively asking for antimicrobial drugs when seeking medical treatment, actively purchasing antimicrobial drugs without prescription at community pharmacies, stocking up on antimicrobial drugs at home, and improperly disposing of antimicrobial drugs decreased by 40%, 30%, 30%, and 50%, respectively, compared with that of the control group.

The study included the development and testing of metaphorical health materials and a multi-contextual metaphorical health education intervention. The implementation of the intervention included training in metaphorical health education and doctor-patient communication, a multi-situational intervention based on the theory of metaphorically embedded integrative behaviours, and the design of incentives for standardised antimicrobial drug discarding.


Eligibility criteria: Inclusion Criteria:

* Residents aged 18 years and over who have lived in the survey township for more than 6 months

Exclusion Criteria:

* Residents with mental illness, severe mental health problems, and those unable to complete the questionnaire

Primary outcomes:
measure: antibiotic use
timeFrame: six months
Secondary outcomes:
measure: knowledge
timeFrame: six months
measure: Prevalence of unsolicited requests for antimicrobial drugs at medical appointments
timeFrame: six months
measure: Prevalence of unsolicited purchase of antimicrobials without a prescription at a pharmacy
timeFrame: six months
measure: Proportion of residents stocking antimicrobial drugs at home
timeFrame: six months
measure: Incidence of unregulated disposal of antimicrobial drugs
timeFrame: six months
Other outcomes:
Locations:
Study officials:
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