Clinical trial NCT04370600: Nutritional Ketosis in Heart Failure
Official title: A Phase 1, Crossover, Pharmacokinetic Study of Nutritional Ketosis on Exercise Capacity, Metabolic Adaptations, and Myocardial Function in Chronic Ambulatory Heart Failure
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: PHASE1
Conditions: Chronic Heart Failure
Keywords: ketosis
beta-hydroxybutyrate
insulin
bioenergetics
exercise tolerance
metabolic
diabetes
Lead sponsor: Thomas Jefferson University
Sponsor class: OTHER
First posted: 2020-05-01
Enrollment: 16
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: CROSSOVER
Intervention model description: Biological drug + placebo (Group A) or placebo + biological drug (Group B)
Primary purpose: TREATMENT

Brief summary: Chronic, ambulatory heart failure patients will be given ketone ester dietary supplementation to determine therapeutic efficacy, metabolic adaptation, pharmacokinetics, associated cognitive changes, and safety within this patient cohort in order to establish preliminary data to later conduct a multi-center randomized clinical trial.

Detailed description: We previously demonstrated a metabolic signature of increased ketone utilization-increased peripheral blood concentration of beta-hydroxybutyrate (BHB) and decreased myocardial concentration of BHB-and markedly decreased acylcarnitine levels in the failing human myocardium procured from lean, non-diabetic patients with advanced heart failure at the time of cardiac transplantation. In this working model of the metabolic adaptations in human heart failure where the mobilization of lipids and ketones are required for an energetically deficient, failing heart it is likely that the development of insulin resistance may be adaptive since increased insulin or insulin signaling would put a brake on the hydrolysis of lipids and hepatic ketogenesis. In parallel with the recent discovery that the failing human heart is reliant on ketones, investigators at Oxford and the NIH have identified a nutritional ketone supplement that reliably increases the serum concentration of BHB in humans.

We hypothesize that the induction of ketosis by exogenous administration of the nutritional ketone monoester will improve myocardial function in heart failure by increasing the energetic substrate available to the myocardium, in essence supporting the energetic deficit of the failing human heart which we have demonstrated to be reliant on ketone bodies for fuel given the limited myocardial oxidation of glucose.

This is a prospective, double-blinded, sequence control crossover trial enrolling NYHA Class II-III ambulatory heart failure patients to receive either ketone mono-ester drink versus placebo for two weeks. Following 2 weeks of therapy, echocardiogram and peak exercise test will be performed. There will be a 1-week "washout" period between phases. Subjects will serve as their own controls for this crossover study, as each will have both baseline testing and testing in the setting of mild nutritional ketosis.

Eligibility criteria: Inclusion Criteria:

1. Equal to or greater than 18 years of age
2. Diagnosis of heart failure and be classified as NYHA Class II or III either pre-enrollment or at the time of enrollment
3. Stable medical therapy for at least 1 month prior to enrollment
4. Taking appropriate daily cardiac medications as determined by the principal investigator, who is a heart failure specialist

Exclusion Criteria:

1. Atrial fibrillation
2. Inability to exercise on a supine bicycle.
3. Moderate or greater valvular disease.
4. Hemoglobin \<10 g/dL.
5. Daily insulin use
6. Hypertrophic, infiltrative, or inflammatory cardiomyopathy.
7. Pericardial disease.
8. Current angina due to clinically significant obstructive epicardial coronary disease
9. Acute coronary syndrome or coronary intervention within the past 2 months.
10. Primary pulmonary arteriopathy.
11. Known clinically significant lung disease defined as:

    1. Current use of supplemental oxygen, aside from nocturnal O2 for the treatment of obstructive sleep apnea
    2. The use of steroids/antibiotics within the past 6 months for an acute exacerbation of obstructive pulmonary disease
    3. Most proximal pulmonary function test indicating severe obstructive disease, defined as an FEV1\<50% predicted in the context of an FEV1/FVC ratio of \<0.70 ("Stage III COPD according to GOLD Criteria). (note: only to be used if the subject had PFTs prior to screening)
    4. Most proximal 6-minute walk test during which the subject experienced arterial desaturation (\<94%) without a subsequent normal study.
12. Ischemia on stress testing without subsequent revascularization or left heart catheterization showing non-obstructive epicardial coronary disease.
13. Significant liver disease impacting synthetic function or volume control.
14. Uncontrolled hypertension: BP \>180/110 at baseline.
15. eGFR \<30 mL/min/m2 or Cr \>2.5.
16. Alcohol dependence
17. Chronic narcotic use that cannot be interrupted
18. Pregnant or lactating females

Primary outcomes:
measure: BHB Concentration in blood
timeFrame: 1 Year
measure: Minutes at maximum exertion [Exercise Capacity]
timeFrame: 1 Year
measure: Left ventricular ejection fraction (%)
timeFrame: 1 Year
measure: Cardiac output (L/min)
timeFrame: 1 Year
measure: Left ventricular end diastolic diameter (LVEDD) (cm)
timeFrame: 1 Year
measure: Insulin concentration
timeFrame: 1 Year
measure: Bicarbonate concentration
timeFrame: 1 Year
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
affiliation: Thomas Jefferson University
name: J. Eduardo Rame, M.D.
role: PRINCIPAL_INVESTIGATOR
References: