Clinical trial NCT03135600: The Influence of Running to ACL Deficiency
Official title: The Influence of Running to Kinematic Parameters of Patients With ACL Deficiency
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: ACL Injury
Gait
Keywords: Knee
ACL Injury
Kinematics
Lead sponsor: Guangzhou General Hospital of Guangzhou Military Command
Sponsor class: OTHER
Collaborators: name: Medical Center of Assessment, Prevention and Treatment of Bone & Joint Diseases, Guangdong, China
name: The First Affiliated Hospital of Guangzhou Medical University
First posted: 2017-05-01
Enrollment: 60
Sex: ALL
Minimum age (years): 20
Maximum age (years): 30
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: FACTORIAL
Primary purpose: BASIC_SCIENCE

Brief summary: The aim of this study is to investigate the influence of running to kinematic parameters of patients with anterior cruciate ligament.


Eligibility criteria: Inclusion Criteria:

1. 20\< age \< 30.
2. Body mass index \< 30.
3. For controls, no history of major injury or surgery in lower limbs; no symptoms of lower limbs; physical examination to test the lower limbs to be healthy.
4. For ACLD group, history of knee injury for at least 2 weeks and able to walk and run; confirmed to be unilateral ACL injury by MRI; knee pain in the knee (ACL injury).
5. The habit of moderate exercise (e.g. Jogging) at least once a week for at least 30 minutes.

Exclusion Criteria:

1. Body mass index \>30.
2. For controls, injury or surgery in hip/knee/ankle.
3. For ACLD group, injury or surgery in hip/ankle; confirmed to be no ACL injury by arthroscopy.
4. Neuropathic disease.
5. Muscular disease.
6. Lack ability to finish the procedure physically or mentally.
7. Easy to fall.
8. Any other conditions that can influence gait parameters of the lower limbs.

Primary outcomes:
measure: Knee flexion/extension angle at initial contact during gait.
timeFrame: 1 Day
measure: Knee internal/external rotation angle at initial contact during gait.
timeFrame: 1 Day
measure: Knee adduction/abduction angle at initial contact during gait.
timeFrame: 1 Day
measure: Knee anterior/posterior translation at initial contact during gait.
timeFrame: 1 Day
measure: Knee medial/lateral translation at initial contact during gait.
timeFrame: 1 Day
measure: Knee proximal/distal translation at initial contact during gait.
timeFrame: 1 Day
measure: Knee flexion/extension angle at opposite toe off during gait.
timeFrame: 1 Day
measure: Knee adduction/abduction angle at opposite toe off during gait.
timeFrame: 1 Day
measure: Knee internal/external rotation angle at opposite toe off during gait.
timeFrame: 1 Day
measure: Knee anterior/posterior translation at opposite toe off during gait.
timeFrame: 1 Day
measure: Knee distal/proximal translation at opposite toe off during gait.
timeFrame: 1 Day
measure: Knee medial/lateral translation at opposite toe off during gait.
timeFrame: 1 Day
measure: Knee flexion/extension angle at heel rise during gait.
timeFrame: 1 Day
measure: Knee internal/external rotation angle at heel rise during gait.
timeFrame: 1 Day
measure: Knee adduction/abduction angle at heel rise during gait.
timeFrame: 1 Day
measure: Knee anterior/posterior translation at heel rise during gait.
timeFrame: 1 Day
measure: Knee distal/proximal translation at heel rise during gait.
timeFrame: 1 Day
measure: Knee medial/lateral translation at heel rise during gait.
timeFrame: 1 Day
measure: Knee flexion/extension angle at opposite initial contact during gait.
timeFrame: 1 Day
measure: Knee adduction/abduction angle at opposite initial contact during gait.
timeFrame: 1 Day
measure: Knee internal/external rotation angle at opposite initial contact during gait.
timeFrame: 1 Day
measure: Knee anterior/posterior translation at opposite initial contact during gait.
timeFrame: 1 Day
measure: Knee distal/proximal translation at opposite initial contact during gait.
timeFrame: 1 Day
measure: Knee medial/lateral translation at opposite initial contact during gait.
timeFrame: 1 Day
measure: Knee flexion/extension angle at toe off during gait.
timeFrame: 1 Day
measure: Knee adduction/abduction angle at toe off during gait.
timeFrame: 1 Day
measure: Knee internal/external rotation angle at toe off during gait.
timeFrame: 1 Day
measure: Knee anterior/posterior translation at toe off during gait.
timeFrame: 1 Day
measure: Knee distal/proximal translation at toe off during gait.
timeFrame: 1 Day
measure: Knee medial/lateral translation at toe off during gait.
timeFrame: 1 Day
measure: Knee flexion/extension angle at feet adjacent during gait.
timeFrame: 1 Day
measure: Knee internal/external rotation angle at feet adjacent during gait.
timeFrame: 1 Day
measure: Knee adduction/abduction angle at feet adjacent during gait.
timeFrame: 1 Day
measure: Knee anterior/posterior translation at feet adjacent during gait.
timeFrame: 1 Day
measure: Knee distal/proximal translation at feet adjacent during gait.
timeFrame: 1 Day
measure: Knee medial/lateral translation at feet adjacent during gait.
timeFrame: 1 Day
measure: Knee flexion/extension angle at tibial vertical during gait.
timeFrame: 1 Day
measure: Knee adduction/abduction angle at tibial vertical during gait.
timeFrame: 1 Day
measure: Knee internal/external rotation angle at tibial vertical during gait.
timeFrame: 1 Day
measure: Knee anterior/posterior translation at tibial vertical during gait.
timeFrame: 1 Day
measure: Knee distal/proximal translation at tibial vertical during gait.
timeFrame: 1 Day
measure: Knee medial/lateral translation at tibial vertical during gait.
timeFrame: 1 Day
measure: Range of motion of knee flexion/extension angle.
timeFrame: 1 Day
measure: Range of motion of knee adduction/abduction angle.
timeFrame: 1 Day
measure: Range of motion of knee internal/external rotation angle.
timeFrame: 1 Day
measure: Range of motion of knee anterior/posterior translation.
timeFrame: 1 Day
measure: Range of motion of knee distal/proximal translation.
timeFrame: 1 Day
measure: Range of motion of knee medial/lateral translation.
timeFrame: 1 Day
Secondary outcomes:
Other outcomes:
Locations:
city: Guangzhou
country: China
facility: Hospital of Orthopedics, Guangzhou General Hospital of Guangzhou Military Command
state: Guangdong
Study officials:
affiliation: Hospital of Orthopedics, Guangzhou General Hospital of Guangzhou Military Command, 111 Liuhua Road, Guangzhou 510010, China
name: Yu Zhang, PhD
role: PRINCIPAL_INVESTIGATOR
References: