Clinical trial NCT00313326: Comparative Study of Duration of Respiratory Weaning Between Adaptive Support Ventilation and Succession of Controlled Ventilation Then Spontaneous Ventilation for Patients After Surgery
Official title: Comparative Study of Duration of Respiratory Weaning Between Adaptive Support Ventilation and Succession of Controlled Ventilation Then Spontaneous Ventilation for Patients After Surgery
Study type: INTERVENTIONAL
Overall status: TERMINATED
Phase: PHASE3
Conditions: Ventilator Weaning
Keywords: Adaptive Support ventilation
Weaning
Lead sponsor: University Hospital, Clermont-Ferrand
Sponsor class: OTHER
First posted: 2006-04-12
Enrollment: 66
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: SINGLE_GROUP
Primary purpose: TREATMENT

Brief summary: This is a comparative study of duration of respiratory weaning between adaptive support ventilation and succession of controlled ventilation then spontaneous ventilation for patients after surgery.

Detailed description: General anaesthesia is marked by the passage of a stage of controlled ventilation where the patient does not carry out any respiratory work and the stage of spontaneous ventilation, which precedes extubation. Adaptive support ventilation (ASV) is a new protocol of weaning of the tracheal prosthesis after surgery which maintains a preset ventilation by an operator and the activity of the patient. At each breath, a microprocessor allows an optimization of volume and frequency by an adjustment of the inspiratory pressure and frequency. ASV was already validated for fast tracheal extubation after cardiac surgery. Our study proposes to compare the duration of intubation between this mode of weaning and with the traditional way (controlled ventilation then spontaneous ventilation) for faster surgery. The purpose of the study is to check the interest of ASV to limit the duration of intubation compared to the traditional protocol in this kind of intervention.

Eligibility criteria: Inclusion Criteria:

* Surgery \< 2 hours
* Anesthesia with thiopental, midazolam, sufentanil and suprane

Exclusion Criteria:

* Patients ASA III or IV (classification of American Sociéty of Anesthésiologist)

Primary outcomes:
measure: Duration of weaning
timeFrame: duration
Secondary outcomes:
measure: Memorizing of weaning
timeFrame: memorizing
Other outcomes:
Locations:
city: Clermont-Ferrand
country: France
facility: Clermont-Ferrand University Hospital
Study officials:
affiliation: University Hospital, Clermont-Ferrand
name: Eric Schneider, Doctor
role: PRINCIPAL_INVESTIGATOR
References:
citation: Petter AH, Chiolero RL, Cassina T, Chassot PG, Muller XM, Revelly JP. Automatic "respirator/weaning" with adaptive support ventilation: the effect on duration of endotracheal intubation and patient management. Anesth Analg. 2003 Dec;97(6):1743-1750. doi: 10.1213/01.ANE.0000086728.36285.BE.
citation: Sulzer CF, Chiolero R, Chassot PG, Mueller XM, Revelly JP. Adaptive support ventilation for fast tracheal extubation after cardiac surgery: a randomized controlled study. Anesthesiology. 2001 Dec;95(6):1339-45. doi: 10.1097/00000542-200112000-00010.