Clinical trial NCT02013219: A Phase 1b Study of Atezolizumab in Combination With Erlotinib or Alectinib in Participants With Non-Small Cell Lung Cancer (NSCLC)
Official title: A Phase 1b Study of the Safety and Pharmacology of Atezolizumab (Anti-PD-L1 Antibody) Administered With Erlotinib or Alectinib in Patients With Advanced Non-Small Cell Lung Cancer
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE1
Conditions: Non-Small Cell Lung Cancer
Lead sponsor: Hoffmann-La Roche
Sponsor class: INDUSTRY
First posted: 2013-12-17
Enrollment: 52
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NON_RANDOMIZED
Intervention model: SEQUENTIAL
Primary purpose: TREATMENT

Brief summary: This open-label, multicenter study will assess the safety, tolerability, and pharmacokinetics of intravenous (IV) dosing of atezolizumab in combination with oral erlotinib or alectinib in participants with NSCLC.

This study has two stages. In the erlotinib group, the combination treatment will be given to participants with epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI)-treatment-naive, advanced (nonresectable) NSCLC in a safety-evaluation stage and to participants with previously untreated EGFR mutation-positive, advanced NSCLC in an expansion stage (Stage 2). In the alectinib group, for both the safety-evaluation and expansion stages (Stages 1 and 2), the combination will be given to participants who are treatment-naive with anaplastic lymphoma kinase (ALK)-positive advanced NSCLC.

In Stage 1, erlotinib will be given at a starting dose of 150 milligrams (mg) by mouth (PO) once daily (QD) and the starting dose of alectinib will be 600 mg twice daily (BID), for 28 consecutive days during Cycle 1 and on Days 1 through 21 of each cycle thereafter. The starting dose of atezolizumab will be 1200 mg, administered every 3 weeks (q3W) starting on Day 8 of Cycle 1. If the starting regimen for a combination treatment is not tolerated, alternative doses and/or schedules of erlotinib and atezolizumab or alectinib and atezolizumab may be tested to determine potential recommended Phase 2 dose (RP2D) for that combination treatment. In Stage 2, a potential RP2D and schedule for each combination treatment will be investigated in an expansion cohort.

For both stages, continuation of treatment beyond Cycle 1 will be at the discretion of the treating investigator. Study treatment will be discontinued in participants who experience disease progression or unacceptable toxicity, are not compliant with the study protocol, or, in their opinion or in the opinion of the investigator, are not benefiting from study treatment. However, in the absence of unacceptable toxicity, participants with second-line or greater NSCLC who are still receiving atezolizumab at the time of radiographic disease progression may be permitted to continue study treatment.


Eligibility criteria: Inclusion Criteria:

* Histologically or cytologically documented, locally advanced or metastatic NSCLC.
* Participants in Stage 1 (Safety Evaluation) receiving erlotinib: No limit to the number of prior therapies (except for EGFR TKIs).
* Participants in Stage 2 (Expansion) receiving erlotinib: i) sensitizing mutation in the EGFR gene and ii) consent to collection of tumor tissue samples before, during, and after treatment for biopsy and PD biomarker analyses.
* Participants receiving alectinib in either Stage 1 or Stage 2: must be ALK positive as assessed by Food and Drug Administration (FDA) approved test and must not have received prior treatment for their advanced NSCLC.
* Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1.
* Life expectancy of at least 12 weeks.
* Measurable disease, as defined by RECIST Version 1.1 (v1.1).
* Adequate hematologic and end-organ function.
* Use of highly effective contraception (as defined by protocol) and until 5 months after the last dose of atezolizumab and for 3 months after the last dose of alectinib or for 2 weeks after the last dose of erlotinib, whichever is longer; Males must also refrain from sperm donatation during this same time period. Participants must not be pregnant or breastfeeding.
* Archival tumor tissue specimen meeting protocol specifications or the participant will be offered the option of a pre-treatment biopsy to obtain adequate tissue sample.

Exclusion Criteria:

* For participants receiving erlotinib group: prior treatment with any EGFR mutant-targeting TKI
* Any approved anticancer therapy, including chemotherapy, or hormonal therapy (except hormone-replacement therapy or oral contraceptives) within 3 weeks of first dose.
* Treatment with any other test drug or participation in another clinical trial within 28 days of enrollment.
* Known symptomatic central nervous system (CNS) metastases. Participants with a history of treated or untreated asymptomatic CNS metastases may be eligible.
* Leptomeningeal disease.
* Uncontrolled tumor-related pain.
* Uncontrolled pleural effusion, pericardial effusion, or ascites requiring drainage at least once monthly.
* High levels of calcium requiring bisphosphonate therapy or denosumab.
* Malignancies other than NSCLC within 5 years prior to enrollment, with the exception of those with a negligible risk of metastasis or death (such as adequately treated carcinoma in-situ of the cervix, basal or squamous cell skin cancer, localized prostate cancer, or ductal carcinoma in situ).
* History of severe allergic, anaphylactic, or other reactions to chimeric or humanized antibodies or fusion proteins.
* Known hypersensitivity to biopharmaceuticals produced in Chinese hamster ovary cells or any component of the atezolizumab formulation.
* History of autoimmune disease.
* Participants with prior bone marrow or solid organ transplantation.
* History of lung inflammation or disease.
* Serum albumin less than (\<) 2.5 grams per deciliter (g/dL).
* Positive for Human Immunodeficiency Virus (HIV).
* Liver disease.
* Current or active tuberculosis, hepatitis B, or hepatitis C.
* Participants with past or resolved hepatitis B virus (HBV) infection are eligible; participants positive for hepatitis C virus (HCV) antibody are eligible only if polymerase chain reaction (PCR) is negative for HCV Riboxy Nucleic Acid (RNA).
* Signs or symptoms of infection within 2 weeks prior to first dosing.
* Received therapeutic oral or IV antibiotics within 2 weeks prior to first dosing.
* Significant cardiovascular disease.
* Major surgical procedure other than for diagnosis within 28 days prior to first dosing or during the course of the study.
* Administration of a live, attenuated vaccine within 4 weeks before first dosing or during the study.
* Any other diseases, metabolic dysfunction, physical examination finding, or clinical laboratory finding that may reasonably prevent the participant from participating.
* Hypersensitivity to erlotinib or alectinib or to any of the excipients.
* Any significant ophthalmologic abnormality. The use of contact lenses is not recommended during the study.
* For participants receiving alectinib: baseline Fridericias corrected QT interval (QTcF) greater than (\>) 470 milliseconds (ms) or symptomatic bradycardia.
* Prior treatment with CD137 agonists or immune checkpoint blockade therapies.
* Treatment with systemic immunostimulatory agents within 6 weeks or five half-lives of the drug, whichever is shorter, prior to first dosing.
* Treatment with systemic immunosuppressive medications within 2 weeks prior to first dosing (inhaled corticosteroids and mineralocorticoids are allowed).
* Participants who received acute, low-dose systemic immunosuppressant medication or a one-time pulse dose of systemic immunosuppressant medication are elgible for study after discussion and approval by the Medical Monitor.

Primary outcomes:
measure: Percentage of Participants with Dose-Limiting Toxicities (DLTs)
timeFrame: 28 days
measure: Recommended Phase II Dose (RP2D) of Atezolizumab and Erlotinib
timeFrame: 28 days
measure: Recommended RP2D of Atezolizumab and Alectinib
timeFrame: 28 days
Secondary outcomes:
measure: Minimum Plasma Concentration (Cmin) of Alectinib and Major Metabolites, as Appropriate
timeFrame: Pre-dose (0 hour) on Day 1 of Cycles 1-4, Day 8 of Cycle 1 (Cycle 1 =28 days; Cycle 2 onwards=21 days)
measure: Progression-Free Survival (PFS) as Assessed Using the Response Evaluation Criteria in Solid Tumors (RECIST)
timeFrame: First dose of study treatment up to disease progression or death from any cause (up to approximately 6 years)
measure: Overall Survival
timeFrame: First dose of study treatment up to death from any cause during the study (up to approximately 6 years)
measure: Percentage of Participants with Objective Response (Complete Response [CR] or Partial Response [PR]) Using RECIST
timeFrame: Baseline up to disease progression or death from any cause (up to approximately 6 years)
measure: Percentage of Participants with Adverse Events
timeFrame: Baseline up to approximately 6 years
measure: Percentage of Participants with Anti-Drug Antibodies (ADAs) Against Atezolizumab
timeFrame: Baseline up to approximately 6 years
measure: Maximum Serum Concentration (Cmax) of Atezolizumab
timeFrame: Day 1 of Cycles 1-4, Day 8 of Cycle 1 (Cycle 1 =21 days; Cycle 2 onwards=28 days)
measure: Minimum Serum Concentration (Cmin) of Atezolizumab
timeFrame: Pre-dose (0 hour) on Day 1 of Cycles 1, 2, 3, 4, 6, and 8 and at study termination (up to approximately 5 years; Cycle 1=21 days; Cycle 2 onwards=28 days)
measure: Maximum Plasma Concentration (Cmax) of Erlotinib
timeFrame: Day 1 of Cycles 1-4, Day 8 of Cycle 1 (Cycle 1 =21 days; Cycle 2 onwards=28 days)
measure: Minimum Plasma Concentration (Cmin) of Erlotinib
timeFrame: Pre-dose (0 hour) on Day 1 of Cycles 1-4, Day 8 of Cycle 1 (Cycle 1 =21 days; Cycle 2 onwards=28 days)
measure: Maximum Plasma Concentration (Cmax) of Alectinib and Major Metabolites, as Appropriate
timeFrame: Day 1 of Cycles 1-4, Day 8 of Cycle 1 (Cycle 1 =21 days; Cycle 2 onwards=28 days)
measure: Duration of Objective Response as Assessed Using RECIST
timeFrame: First occurrence of a documented objective response up to disease progression or death from any cause (up to approximately 6 years)
measure: Percentage of Participants with Best Overall Response
timeFrame: Baseline up to disease progression or death from any cause (up to approximately 6 years)
Other outcomes:
Locations:
city: Orange
country: United States
facility: UC Irvine Medical Center
state: California
city: New Haven
country: United States
facility: Yale University School Of Medicine
state: Connecticut
city: Orlando
country: United States
facility: Florida Hospital Cancer Inst
state: Florida
city: Chicago
country: United States
facility: University of Chicago
state: Illinois
city: Boston
country: United States
facility: Massachusetts General Hospital;Hematology/ Oncology
state: Massachusetts
city: Boston
country: United States
facility: Beth Israel Deaconess Med Ctr; Neurology/MS Center
state: Massachusetts
city: Boston
country: United States
facility: Dana Farber Cancer Institute
state: Massachusetts
city: Detroit
country: United States
facility: Karmanos Cancer Center; Department of Oncology
state: Michigan
city: New York
country: United States
facility: Memorial Sloan Kettering - Basking Ridge
state: New York
city: Cleveland
country: United States
facility: Case Western Reserve University; Medicine-Hematology and Oncology
state: Ohio
city: Villejuif
country: France
facility: Institut Gustave Roussy
city: Shatin
country: Hong Kong
facility: The Chinese University of Hong Kong
city: Seoul
country: Korea, Republic of
facility: Seoul National University Hospital
city: Seoul
country: Korea, Republic of
facility: Asan Medical Center
city: Madrid
country: Spain
facility: START Madrid. Centro Integral Oncologico Clara Campal; CIOCC
city: Valencia
country: Spain
facility: Hospital Clinico Universitario de Valencia
city: London
country: United Kingdom
facility: Queen Mary University of London
Study officials:
affiliation: Hoffmann-La Roche
name: Clinical Trials
role: STUDY_DIRECTOR
References: