louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT04430322: Covid-19 at the Regional Medical Center Metz-Thionville: a Descriptive Study
Official title: Coronavirus Disease 2019 (Covid-19) at the Regional Hospital Center Metz-Thionville: a Descriptive Study
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: COVID
Lead sponsor: Centre Hospitalier Régional Metz-Thionville
Sponsor class: OTHER
First posted: 2020-06-12
Enrollment: 1045
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: OTHER
Time perspective: RETROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Patient hospitalized in COVID Unit at the Regional Hospital Center Metz-Thionville during the COVID-19 pandemic with a PCR positive or COVID confirmed with clinical evidence and CT scan.

Brief summary: France and especially the region "Grand Est" have been damaged by the COVID-19 pandemic. This pandemic resulted in a reorganization of the hospitalization sectors.

In order to better understand the disease, the investigators wish to carry out a descriptive analysis of hospitalized patient data. This study would notably allow us to identify some prognostic factors.

The main objective of this study is to identify individual factors that are associated with a poor prognosis (with ICU admission or death).


Eligibility criteria: Inclusion Criteria:

* Patient hospitalized in COVID Unit at the Regional Hospital Center Metz-Thionville during the COVID 19 pandemic
* PCR positive or COVID confirmed with clinical evidence and CT scan

Exclusion Criteria:

* Patients not willing to participate via using their medical files
* Patient transferred after a brief stay in another hospital

Primary outcomes:
measure: ICU admission
timeFrame: Day 1
Secondary outcomes:
measure: Hospitalization
timeFrame: Day 1
measure: Length of stay at the ICU
timeFrame: Day 1
measure: Death
timeFrame: Day 1
measure: CT scan result
timeFrame: Day 1
measure: C reactive protein
timeFrame: Day 1
measure: Blood Count
timeFrame: Day 1
measure: Sodium
timeFrame: Day 1
measure: Urea
timeFrame: Day 1
measure: Troponine
timeFrame: Day 1
measure: Liver function
timeFrame: Day 1
measure: Coagulation test
timeFrame: Day 1
measure: Creatinine
timeFrame: day 1
measure: Clearance
timeFrame: day 1
measure: Potassium
timeFrame: day 1
measure: Calcium
timeFrame: day 1
measure: Gamma-glutamyl transpeptidase
timeFrame: day 1
measure: Bilirubine
timeFrame: day 1
measure: Alcaline phosphatase
timeFrame: Day 1
measure: Prothrombine
timeFrame: Day 1
Other outcomes:
Locations:
city: Metz
country: France
facility: CHR Metz Thionville
Study officials:
References:
Clinical trial NCT06381622: Combining Lidocaine and Ropivacaine for an Infraclavicular Brachial Plexus Nerve Block
Official title: The Effect of Combining Lidocaine and Ropivacaine on the Duration and Onset Time of an Ultrasound-guided Infraclavicular Brachial Plexus Nerve Block. a Randomized Controlled Trial
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE3
Conditions: Nerve Block
Anesthesia, Local
Forearm Fracture
Surgery
Brachial Plexus Block
Keywords: Anesthetics, Local
Lidocaine
Ropivacaine
Lead sponsor: Nordsjaellands Hospital
Sponsor class: OTHER
First posted: 2024-04-24
Enrollment: 78
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The aim of the study is to investigate how the combination of ropivacaine (a slow onset, long duration local anesthetic) with lidocaine (a rapid onset, shorter duration local anesthetic) affects the onset and duration of a lateral infraclavicular plexus brachialis (LIC) block in patients undergoing non-acute hand surgery.


Eligibility criteria: Patient who have given written informed consent to participate in the study, after having understood it

Inclusion Criteria:

* Scheduled for non-acute hand surgery in regional anesthesia
* Scheduled for surgery on one of the following: 1) Antebrachium fractures or 2) Arthroplasty of a thumb base joint or 3) alloplasty of a thumb base joint

Exclusion Criteria:

* BMI \> 40 kg/m2
* Weight \< 60 kg
* Age \< 18 years
* ASA physical status classification system grade \> 3
* Allergy to experimental drugs
* Patients who cannot cooperate with the examinations or treatment
* Patients who do not understand or speak Danish
* Patients with peripheral or central neurological disease or nerve damage with neurological effect on the upper extremity, where surgery is required

Primary outcomes:
measure: Total time to breakthrough pain
timeFrame: 24 hours
Secondary outcomes:
measure: The onset of sensory block
timeFrame: Until max 45 minutes
measure: Total duration of sensory blockade
timeFrame: 24 hours
measure: Total duration of motor blockade
timeFrame: 24 hours
measure: Degree of motor blockade
timeFrame: At complete sensory blockade and otherwise 45 minutes after block performance
Other outcomes:
measure: Pain intensity at pain breakthrough
timeFrame: At pain breakthrough until a maximum of 24 hours after performed block.
measure: Duration of maximum pain intensity after the blockade has ended
timeFrame: After the blockade has ended until a maximum of 24 hours after performed block.
measure: Occurence of adverse events (AE) and serious adverse events (SAE)
timeFrame: Follow up after 24 hours and 30 days
measure: Failed blockade
timeFrame: Evaluated 30 minutes after completed surgery
measure: The patient's experience of the treatment (patient satisfaction)
timeFrame: 24 hours
Locations:
city: Hillerød
country: Denmark
facility: Nordsjælland Hospital
Study officials:
affiliation: Nordsjællands Hospital, Københavns Universitet, Hillerød
name: Christian Rothe, PhD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT06003322: Non - Incised Papilla Versus Single Flap Technique In The Reconstruction Of Intrabony Defect
Official title: Non - Incised Papilla Versus Single Flap Technique In The Reconstruction Of Intrabony Defect: a Randomized Controlled Trial
Study type: INTERVENTIONAL
Overall status: RECRUITING
Phase: NA
Conditions: Periodontal Attachment Loss
Lead sponsor: Ain Shams University
Sponsor class: OTHER
Collaborators: name: Assiut University
name: Egyptian Russian University
First posted: 2023-08-21
Enrollment: 20
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The present study will aim to assess the effectiveness of the non-Incised Papilla surgical approach NIPSA used for the surgical debridement of deep intraosseous defects compared to the single-flap approach SFA.

Primary outcome: interproximal clinical attachment level gain Secondary outcomes: residual probing pocket depth (PPD), pocket depth (PD) reduction, recession (REC), location of the tip of the papilla (TP), width of the keratinized tissue (KT), wound closure (WC), supra-alveolar attachment gain (SUPRA-AG)

Detailed description: The present study will aim to assess the effectiveness of the non-Incised Papilla surgical approach NIPSA used for the surgical debridement of deep intraosseous defects compared to the single-flap approach SFA.

Primary outcome: interproximal clinical attachment level gain Secondary outcomes: residual probing pocket depth (PPD), pocket depth (PD) reduction, recession (REC), location of the tip of the papilla (TP), width of the keratinized tissue (KT), wound closure (WC), supra-alveolar attachment gain (SUPRA-AG)

Eligibility criteria: Inclusion Criteria:

* - Age \> 18 years
* Diagnosis with stage III-IV periodontitis.
* Presence of one or more intrabony defects with probing pocket depth (PPD) \> 5 mm and radiographic defect depth \> 4 mm.
* Full-mouth plaque score (FMPS) and full-mouth bleeding score (FMBS) \< 30% (measured at four sites per tooth).
* No relevant systemic condition or disease.

Exclusion Criteria:

Third molars and teeth with type III mobility or with an incorrect endodontic or restorative treatment.

-

Primary outcomes:
measure: interproximal clinical attachment level change
timeFrame: at baseline ,6 and 12 months
Secondary outcomes:
measure: residual probing pocket depth (PPD), pocket depth (PD) change,
timeFrame: at at baseline ,6 and 12 months
Other outcomes:
Locations:
city: Assiut
country: Egypt
facility: faculty of dentistry ,Assiut university
Study officials:
affiliation: Assiut University
name: ALAA T ALI, PhD
role: STUDY_DIRECTOR
References:
Clinical trial NCT04192422: DiGESTnewborn Study
Official title: Glucose Control and Metabolic Adaptation in Offspring of Women With Gestational Diabetes Recruited to the DiGest Study
Study type: OBSERVATIONAL
Overall status: RECRUITING
Conditions: GDM
Hypoglycemia
Lead sponsor: Cambridge University Hospitals NHS Foundation Trust
Sponsor class: OTHER
First posted: 2019-12-10
Enrollment: 60
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Mothers and their babies who have been enrolled in DiGest Trial a trial of dietary intervention in women with gestational diabetes

Brief summary: We wish to study the effect of a mothers sugar (glucose) control during pregnancy on her baby's sugar control after birth.


Eligibility criteria: Inclusion Criteria:

* mothers and their babies who have been enrolled in DiGest Trial and who have provided informed consent

Exclusion Criteria:

* none

Primary outcomes:
measure: Neonatal sensor glucose time in target
timeFrame: From sensor insertion for up to the first 7 days of life
Secondary outcomes:
Other outcomes:
Locations:
city: Cambridge
country: United Kingdom
facility: Addenbrookes Hospital
Study officials:
References:
Clinical trial NCT03613922: Effects of Early Manual Therapy on Functional Outcomes After Volar Plating of Distal Radius Fractures
Official title: Effects of Early Manual Therapy on Functional Outcomes After Volar Plating of Distal Radius Fractures: A Randomized Controlled Trial
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Distal Radius Fracture
Keywords: manual therapy
radius fracture
function
disability
physiotherapy
Lead sponsor: Dokuz Eylul University
Sponsor class: OTHER
First posted: 2018-08-03
Enrollment: 32
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The aim of the study was to investigate the effects of early manual therapy on function, pain, range of motion (ROM), hand and pinch grip strength and disability level in patients underwent volar plating after distal radius fracture (DRF). Patients were randomly divided into two groups: Routin Physiotherapy (RP) or Early Manual Therapy (EMT). While RP group received routine physiotherapy, EMT group received routine physiotherapy plus Mulligan's Mobilization With Movement technique. All treatments were done two sessions a week, through 12 weeks. Function, pain, range of motion (ROM), hand and pinch grip strength and disability level of patients were assessed. Measurements were made at postoperative week 3, 6 and 12.


Eligibility criteria: Inclusion Criteria:

* An age of eighteen years or older
* An unstable fracture of the distal end of the radius
* Fixation with a volar locking plate
* Able to read, write, and understand Turkish
* Willing and able to attend the study

Exclusion Criteria:

* Previous fracture on the injured side
* Concurrent fracture in contralateral upper extremity
* Accompanied bony and soft tissue injuries other than radius fracture
* Inflammatory joint diseases, metabolic diseases and neurological diseases
* Mental and cognitive disorders that would seriously affect cooperation

Primary outcomes:
measure: change in the function
timeFrame: postoperative week 6, 12.
Secondary outcomes:
measure: change in the severity of pain
timeFrame: postoperative day 1, postoperative week 3, 6, 12.
measure: change in the range of motion (ROM)
timeFrame: postoperative week 3, 6, 12.
measure: change in hand and pinch grip strength
timeFrame: postoperative week 3, 6, 12.
measure: change in disability
timeFrame: postoperative week 6, 12.
Other outcomes:
Locations:
city: Izmir
country: Turkey
facility: Dokuz Eylul University
Study officials:
References:
Clinical trial NCT00959322: A Prospective Single Center Clinical Study for Capsulotomy Using the LenSx 550 Laser
Official title: A Prospective Single Center Clinical Study for Capsulotomy Using the LenSx 550 Laser
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Cataract
Keywords: Capsulotomy
Lead sponsor: LenSx Lasers Inc.
Sponsor class: INDUSTRY
First posted: 2009-08-14
Enrollment: 60
Sex: ALL
Minimum age (years): 24
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: TREATMENT

Brief summary: The LenSx 550 laser system is a femtosecond laser intended for use in performing anterior capsulotomy during cataract surgery. The anterior capsulotomy creates a circular opening in the anterior surface of the capsular bag that contains the cataractous crystalline lens. The objective of this study is to evaluate the ability of the LenSx 550 laser to successfully perform anterior capsulotomy during cataract surgery.


Eligibility criteria: Inclusion Criteria:

* Must be eligible to undergo cataract extraction by phacoemulsification with primary intraocular lens implantation in at least 1 eye.
* Must be at least 24 years of age.
* Must be willing and able to return for scheduled follow-up examinations.
* Subjects must sign and be given a copy of the written Informed Consent form.

Exclusion Criteria:

* Corneal disease or pathology that precludes applanation of the cornea or transmission of laser wavelength or distortion of laser light.
* Subjects with a poorly dilating pupil or other defect of the pupil that prevents the iris from adequate retraction peripherally are excluded.
* Subjects with residual, recurrent, active ocular or eyelid disease, including any corneal abnormality (for example, recurrent corneal erosion, severe basement membrane disease) in either eye are excluded.
* History of steroid-responsive rise in intraocular pressure, glaucoma, or preoperative IOP\>21 mm Hg in either eye.
* Lens/zonular instability such as, but not restricted to, Marfan's Syndrome, Pseudoexfoliation Syndrome, etc.
* Previous intraocular or corneal surgery of any kind, including any type of surgery for either refractive or therapeutic purposes in either eye.
* Subjects who are pregnant, lactating, or planning to be pregnant during the course of the study.
* Known sensitivity to planned study concomitant medications.
* Subjects participating in any other ophthalmic drug or device clinical trial during the time of this clinical investigation.
* Subjects presenting any contraindications to cataract surgery.

Primary outcomes:
measure: Capsulotomy is complete
timeFrame: 1 day, 1 week, 1 month
Secondary outcomes:
measure: No radial tears noted intraoperatively
timeFrame: 1 day, 1 week, 1 month
Other outcomes:
Locations:
city: Budapest
country: Hungary
facility: Semmelweis University
Study officials:
affiliation: LenSx Lasers Inc.
name: Ronald M Kurtz, M.D.
role: STUDY_CHAIR
affiliation: LenSx Lasers Inc.
name: Melvin Sarayba, M.D.
role: STUDY_DIRECTOR
References:
Clinical trial NCT05190822: Evaluation of University Students' Knowledge Levels and Perceptions of the Physiotherapist
Official title: Evaluation of University Students' Knowledge Levels and Perceptions of the Physiotherapist in Turkey: A Health-Areas University Example
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Physical Therapist
Lead sponsor: Acibadem University
Sponsor class: OTHER
First posted: 2022-01-13
Enrollment: 600
Sex: ALL
Minimum age (years): 18
Maximum age (years): 25
Standard ages: ADULT
Accepts healthy volunteers: yes
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: The current study will be conducted by face-to-face interviews within the scope of questionnaires prepared by us for students studying in departments other than Physiotherapy and Rehabilitation at Acibadem Mehmet Ali Aydinlar University

Brief summary: The aim of this study is to determine the knowledge, perceptions and perspectives of students about physiotherapy and rehabilitation profession, who are studying in different departments, especially in the health sector in Turkey.


Eligibility criteria: Inclusion Criteria:

* Individuals between the ages of 18-25 who are students and continue their education at Acibadem Mehmet Ali Aydinlar University

Exclusion Criteria:

* Students in the physiotherapy and rehabilitation department
* Students with serious mental illness

Primary outcomes:
measure: Knowledge of students about the physiotherapist profession
timeFrame: Baseline time
measure: Perceptions of students about the physiotherapist profession
timeFrame: Baseline time
Secondary outcomes:
measure: Knowledge of students about the physiotherapist of health fields
timeFrame: Baseline time
Other outcomes:
Locations:
city: Istanbul
country: Turkey
facility: Acibadem University
Study officials:
affiliation: Acibadem University
name: Nuray ALACA, Asocc. Prof
role: STUDY_DIRECTOR
References:
Clinical trial NCT04434222: Compressive Stockings Therapy After TKA
Official title: Effect of Compliance Controlled Postoperative Compressive Stockings Therapy After Total Knee Arthroplasty: a Randomized Controlled Trial
Study type: INTERVENTIONAL
Overall status: TERMINATED
Phase: NA
Conditions: Compliance of Wearing of Compressive Stockings
Total Knee Arthroplasty
Lead sponsor: Balgrist University Hospital
Sponsor class: OTHER
First posted: 2020-06-16
Enrollment: 20
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: Due to swelling after total knee arthroplasty, postoperative mobilization and training is impeded in addition to higher pain level in patients. With postoperative compressive stockings to prevent oedema, haematoma and postoperative pain we would like to investigate if compressive stockings reduce postoperative swelling and pain and furthermore improve mobilization and knee function.

In this randomized controlled trial, 88 patients are randomized in two groups. One group receives postoperatively compressive stockings for a period of 6 weeks. The control group is treated without compressive stockings. The patients compressive stockings wearing compliance is controlled with a temperature sensitive sensor. The patients will be informed about the implantation of the sensor.

Outcome measures are knee- calf- and ankle swelling in mm, pain, WOMAC and KSS score preoperatively and at 12 weeks, 12 months and 24 months.


Eligibility criteria: Inclusion Criteria:

* Patients receiving a total knee replacement
* Written consent of the study participant

Exclusion Criteria:

* Peripheral arterial disease II, III or IV
* Diabetes mellitus
* Systemic inflammatory diseases
* Benign or malignant neoplasms
* Revision interventions
* Right heart failure
* pulmonary edema
* Open / chronic skin lesions

Primary outcomes:
measure: Knee Function KSS 6 weeks postoperative
timeFrame: 6 weeks postoperative
measure: Knee Function KSS 12 weeks postoperative
timeFrame: 12 weeks postoperative
measure: Knee Function KSS 1 year postoperative
timeFrame: 1 year postoperative
measure: Knee Function WOMAC 6 weeks postoperative
timeFrame: 6 weeks postoperative
measure: Knee Function WOMAC 12 weeks postoperative
timeFrame: 12 weeks postoperative
measure: Knee Function WOMAC 1 year postoperative
timeFrame: 1 year postoperative
measure: Pain 6 weeks postoperative
timeFrame: 6 weeks postoperative
measure: Pain 12 weeks postoperative
timeFrame: 12 weeks postoperative
measure: Pain 1 year postoperative
timeFrame: 1 year postoperative
Secondary outcomes:
measure: Swelling 6 weeks postoperative
timeFrame: 6 weeks postoperative
measure: Swelling 12 weeks postoperative
timeFrame: 12 weeks postoperative
measure: Swelling 1 year postoperative
timeFrame: 1 year postoperative
measure: Compliance first 6 weeks postoperativ
timeFrame: First 6 weeks postoperativ
Other outcomes:
Locations:
city: Zürich
country: Switzerland
facility: Universitätsklinik Balgrist
Study officials:
References:
Clinical trial NCT02498522: Effect of Metformin on Early Pregnancy Loss in Pregnant Women With Polycystic Ovarian Syndrome
Official title: Effect of Metformin on Early Pregnancy Loss in Pregnant Women With Polycystic Ovarian Syndrome
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: EARLY_PHASE1
Conditions: Polycystic Ovary Syndrome
Lead sponsor: Ain Shams University
Sponsor class: OTHER
First posted: 2015-07-15
Enrollment: 166
Sex: FEMALE
Minimum age (years): 25
Maximum age (years): 35
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: PREVENTION

Brief summary: The aim of this work is to study the effect of metformin use for reducing early pregnancy loss in pregnant patients with Polycystic ovary syndrome (PCOS).

Detailed description: Polycystic ovary syndrome (PCOS) is the most common endocrine disorder in women of reproductive age. PCOS produces symptoms in approximately 5 to 10% of women of reproductive age (12-45 years old) and is thought to be one of the leading causes of the female subfertility

* The aim of this work is to study the effect of metformin use for reducing early pregnancy loss in pregnant patients with PCOS
* Research question:

In pregnant women with PCOS, does metformin use decreases the rate of early pregnancy loss?

-Research hypothesis: In Pregnant women with PCOS, metformin may reduce the rate of early pregnancy loss.

Eligibility criteria: Inclusion Criteria:

* Age : 25 - 35.
* Pregnant patients in their 1st trimester with history of infertility due to PCOS confirmed by at least 2 of the following criteria ( Rotterdam Criteria )

  * At least twelve small follicles 2-9 mm in at least one ovary; diagnosed by ultra sound examination.
  * Symptoms or biochemical evidence of hyperandrogenism; diagnosed by examination and laboratory investigations.
  * Anovulation or oligo-ovulation with fewer than nine menstrual periods every 12 months : diagnosed by thorough history taking.
* Non diabetic patients who received metformin along with other ovulation-inducing drugs prior to pregnancy.

Exclusion Criteria:

* patients with other causes of infertility other than PCOS
* contraindications to metformin : liver impairment , renal failure.
* Patients with PCOS who didn't receive Metformin with drugs of induction of ovulation before pregnancy.

Primary outcomes:
measure: Miscarriage Rate
timeFrame: 6 months
Secondary outcomes:
Other outcomes:
Locations:
city: Cairo
country: Egypt
facility: Faculty of Medicine, Ain Shams University
state: Al Qahirah
Study officials:
affiliation: Ain Shams University
name: Ahmed M kotb, MD
role: PRINCIPAL_INVESTIGATOR
References: