Clinical trial NCT06157632: Role of Preoperative Serum Thyroglobulin Level to Differentiate Between Different Thyroid Nodules
Official title: Role of Preoperative Serum Thyroglobulin Level to Differentiate Between Different Thyroid Nodules
Study type: INTERVENTIONAL
Overall status: NOT_YET_RECRUITING
Phase: NA
Conditions: Level of Thyrogobulin in Different Thyroid Nodules
Lead sponsor: Assiut University
Sponsor class: OTHER
First posted: 2023-12-06
Enrollment: 30
Sex: ALL
Minimum age (years): 15
Maximum age (years): 70
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Intervention model description: patients with thyoid nodules that will do thyriodectomy
Primary purpose: DIAGNOSTIC

Brief summary: Role of preoperative serum thyroglobulin level to differentiate between different thyroid nodules

Detailed description: Incidence of thyroid nodules varies according to the methods of diagnosis, 4-7% by palpation and 17-67% by high resolution ultrasound.

The gold standard of diagnosis for thyroid nodules is fine needle aspiration (FNA); however, fine needle aspiration cytology (FNAC) alone is insufficient to detect cancer because of inadequate cytology (5-15%) and in cases of follicular neoplasm (15-25%) where only surgery is diagnostically conclusive. Therefore, other factors in addition to FNA should be considered to predict malignancy. This study is done to evaluate the association between elevated pre-operative thyroglobulin levels and histopathologically proven thyroid carcinoma.

Metabolism of thyroglobulin occurs in the liver and via thyroid gland and recycling of the protein takes place. Circulating thyroglobulin features a half lifetime of 65 hours. Following thyroidectomy, it will take many weeks before thyroglobulin levels become undetectable. After thyroglobulin levels become undetectable (following thyroidectomy), levels are often serially monitored.

A subsequent elevation of the thyroglobulin level is an indicator of recurrence of papillary or follicular thyroid carcinoma. Hence, thyroglobulin levels in the blood are mainly used as a tumor marker for certain kinds of thyroid cancer (particularly papillary or follicular thyroid cancer). Thyroglobulin is not produced by medullary or anaplastic carcinoma.

Therefore, this study tries to evaluate the association between the preoperative thyroglobulin levels and thyroid carcinoma proven by post-operative histopathology.

Eligibility criteria: Inclusion Criteria:

1. age between 15 to 70 years old
2. patients with solitary thyroid nodules
3. pateints who are fit for surgeries

Exclusion Criteria:

* 1_patients who are unfit for surgeries

  2_ age below 15 years and above 70 years old

  3-patients with thyroid nodule receiving drugs that affect thyroglobulin level as iodine

Primary outcomes:
measure: Role of preoperative serum thyroglobulin level to differentiate between different thyroid nodules
timeFrame: Two year
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
affiliation: Assiut University
name: Mohamed Baker, Prof
role: STUDY_DIRECTOR
affiliation: Assiut University
name: Mahmoud Thabet, Assistant.prof
role: STUDY_DIRECTOR
References: