louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT04348786: Comparing Efficacy of 14-day Therapy Doxycycline With Bismuth Subsalicylate Versus Levofloxacin With Tinadizole on Treatment Helicobacter Pylori
Official title: Comparing the Efficacy of 14-day Therapy Doxycycline With Bismuth Subsalicylate Versus Levofloxacin With Tinidazole on Rate of Eradication of Helicobacter Pylori Infected Patients on Syrian Population
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE4
Conditions: Helicobacter Pylori Infection
Keywords: Doxycyclien
Bismuth Subsalicylate
Helicobacter Pylori
levofloxacine
tinadizole
Lead sponsor: Damascus Hospital
Sponsor class: OTHER
First posted: 2020-04-16
Enrollment: 78
Sex: ALL
Minimum age (years): 18
Maximum age (years): 80
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: Comparison Efficacy of 10-days Therapy with Doxycycline with Bismuth Subsalicylate Versus Levofloxacine with Tinadizole on Eradication of Helicobacter Pylori in Syrian population.


Eligibility criteria: Inclusion Criteria:

* Patients are aged greater than 18 years old who have H. pylori infection diagnosed by any of following three methods:
* Positive rapid urease test (CLOtest).
* Histologic evidence of H. pylori by modified Giemsa staining.
* Positive 13C-urea breath test. without prior eradication therapy and are willing to receive therapy.

Exclusion Criteria:

* Children and teenagers aged less than 18 years.
* Previous eradication treatment for H. pylori.
* Patients who took any drug, which could influence the study results such as proton pump inhibitor, H2 blocker, mucosal protective agent and antibiotics.
* History of gastrectomy.
* Gastric malignancy, including adenocarcinoma and lymphoma,
* Previous allergic reaction to antibiotics (Amoxicillin, Tinadizole,
* Doxycycline,Bismuth subsalicylate,) and prompt pump inhibitors (Es- omeprazole).
* Contraindication to treatment drugs.
* Pregnant or lactating women.
* Severe concurrent disease.
* Liver cirrhosis.

Primary outcomes:
measure: Eradication rate of Helicobacter pylori infection
timeFrame: 8 week from begning of treatment
Secondary outcomes:
Other outcomes:
Locations:
city: Damascus
country: Syrian Arab Republic
facility: General Assembly of Damascus Hospital
Study officials:
affiliation: general assambly of damascus hospital
name: Marouf M Alhalabi, MD
role: PRINCIPAL_INVESTIGATOR
References:
citation: Alhalabi M, Alassi MW, Alaa Eddin K, Cheha K. Efficacy of two-week therapy with doxycycline-based quadruple regimen versus levofloxacin concomitant regimen for helicobacter pylori infection: a prospective single-center randomized controlled trial. BMC Infect Dis. 2021 Jul 4;21(1):642. doi: 10.1186/s12879-021-06356-5.
Clinical trial NCT04309786: Somatization, Anxiety, and Disordered Sleep in Pediatric Eosinophilic Esophagitis
Official title: A Pilot Study of Somatization, Anxiety and Sleep Disorders in Pediatric Patients With Eosinophilic Esophagitis
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Eosinophilic Esophagitis
Keywords: EoE
Lead sponsor: University of California, San Diego
Sponsor class: OTHER
Collaborators: name: Wake Forest University
First posted: 2020-03-16
Enrollment: 98
Sex: ALL
Minimum age (years): 8
Maximum age (years): 18
Standard ages: CHILD
ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Children 8-18 years old seen in the Rady Children's EoE clinic population as part of routine care (n=60) patients

Brief summary: Eosinophilic esophagitis

Detailed description: In order to decrease disease burden and the perception of disease burden, investigators need to understand the symptoms and severity of anxiety, disordered sleep, and somatization and how these parameters align with symptoms and quality of life in pediatric EoE. To assess the burden of these parameters in children with EoE, investigators will conduct a single center pilot study of 60 children with EoE using validated indexes for anxiety (state trait anxiety inventory for children), somatization (children's somatization inventory), sleep (pediatric sleep questionnaire), coping (Connor-Davidson Resilience Score) symptoms (PEESSv2.0), and quality of life (PedsQL-EoE).

Eligibility criteria: Inclusion Criteria:

* Age 8-18 years old
* Ability to understand and complete the surveys and complete them in English
* Known diagnosis of EoE defined as \> 15 eosinophils per high power field. Patient can have active or inactive disease at the time of entry

Exclusion Criteria:

* \<8 or \> 18 years old
* Inability to read the surveys in English
* Concurrent gastrointestinal diseases such as inflammatory bowel disease or Celiac disease.

Primary outcomes:
measure: Somatization score
timeFrame: Two weeks
measure: Sleep Quality score
timeFrame: Up to One month or in general
measure: Anxiety score
timeFrame: At the moment and usually
measure: Resilience score
timeFrame: One Month
measure: Symptoms score
timeFrame: One month
measure: Quality of Life score
timeFrame: One Month
Secondary outcomes:
Other outcomes:
Locations:
city: San Diego
country: United States
facility: Rady Children's Hospital San Diego
state: California
Study officials:
References:
Clinical trial NCT03524586: Comparison of the Cuff Pressure of a Taper-guard Cuffed Tube Between Ipsilateral and Contralateral Rotation of Head
Official title: Comparison of the Endotracheal Tube Cuff Pressure of a Taper-guard Cuffed Tube Between Ipsilateral and Contralateral Rotation of Head During Tympanoplasty; Prospective Study.
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Anesthesia, Endotracheal
Airway Management
Lead sponsor: Kyungpook National University Hospital
Sponsor class: OTHER
First posted: 2018-05-15
Enrollment: 52
Sex: ALL
Minimum age (years): 18
Maximum age (years): 80
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: SCREENING

Brief summary: This study evaluates the endotracheal tube cuff pressure of a taper-guard cuffed tube during tympanoplasty with ipsilateral rotation of head, compared to the contralateral rotation of head.

The investigators will performed the ipsilateral rotation of head against the fixed tube in half of participants or the contralateral rotation of head in the other half.

Detailed description: The inflation of the endotracheal tube cuff is very useful to prevent aspiration of contaminated substances into lung past endotracheal tube and leakage of gas during positive pressure ventilation. However, excessive inflation of endotracheal tube cuff frequently causes tracheal mucosal damage, which can increase the incidence of sore throat, hoarseness, and coughing after surgery.

Taper-guard cuffed tube was newly developed. Taper-guard endotracheal tube is more effective in providing a sealing effect than a cylindrical endotracheal tube in an in vitro study. However, recently, it was reported that the cuff pressure of a Taper-guard endotracheal tube significantly increased after a positional change from the supine to the lateral flank position, compared to that of a cylindrical endotracheal tube. However, during tympanoplasty, the investigators need to rotate head for proper position.

In this study, therefore, the investigators investigate the difference of the endotracheal tube cuff pressure of a taper-guard cuffed tube between ipsilateral and contralateral rotation of head against the fixed tube during tympanoplasty.

Eligibility criteria: Inclusion Criteria:

* American Society of Anesthesiologists physical status classification I-III for a tympanoplasty under general anesthesia

Exclusion Criteria:

* history of difficult intubation, limited neck movement, respiratory diseases, and body mass index \>35kg/m2

Primary outcomes:
measure: The endotracheal tube cuff pressure
timeFrame: During procedure
Secondary outcomes:
measure: The distance from the endotracheal tube tip to the carina
timeFrame: During procedure
Other outcomes:
Locations:
city: Daegu
country: Korea, Republic of
facility: Kyungpook national university hospital
Study officials:
affiliation: Kyungpook National University Hospital
name: Saeyoung Kim
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT03056586: The Effect of Pessary Post Vaginal Prolapse Repair, for One Month, to Reduce the Recurrence Rate of Prolapse
Official title: The Recurrence Rate of Genital Prolapse Post Repair With the Use of PESSARY for One Month Post Operative
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Use of Pessary Reduce the Number of Prolapse Recurrence
Uterine Prolapse
Cystocele
Rectocele
Lead sponsor: Meir Medical Center
Sponsor class: OTHER
First posted: 2017-02-17
Enrollment: 100
Sex: FEMALE
Minimum age (years): 30
Maximum age (years): 80
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NON_RANDOMIZED
Intervention model: PARALLEL
Primary purpose: PREVENTION

Brief summary: Genital prolapse is a common complain. 30-40% of women will complain of uterine prolapse or cystocele or rectocele, or mixed. About half of them will require surgical repair for the prolapse, with or without hysterectomy. Of these patients about 30-40% will have recurrence of the prolapse, which in some cases requires second operation.

In this study the investigators want to investigate whether a vaginal pessary inserting in the end of the primary surgery, for 4 weeks, will reduce the recurrence rate.

Detailed description: All patients going for vaginal surgery for genital prolapse, stage 3-4, with cystocele, rectocele or uterine cervix prominent from the vagina. These patients, after signing an informed consent, a vaginal pessary will insert at the end of the operation and will stay for 4 weeks post-op.

After 4 weeks the pessary will be removed, and the patient will followed for 2 years, for recurrence of prolapse.

Eligibility criteria: Inclusion Criteria:

* all healthy patients with genital prolapse grade 3-4, going for vaginal surgery
* age 30-80years

Exclusion Criteria:

* patients with pelvic inflammatory disease
* patients after pelvic irradiation
* large vaginal erosion
* vaginal bleeding uncontrolled or undiagnosed
* patients going for surgery with mesh

Primary outcomes:
measure: Reduction of recurrence rate of vaginal prolapse, post vaginal surgery repair.
timeFrame: 24 month
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
References:
Clinical trial NCT01711086: Safety and Efficacy of the Inspiromatic Inhaler in Comparison to the Aerolizer Inhaler When Delivering Formoterol
Official title: Double Blind Placebo Controlled Trial Checking the Safety and Efficacy of the Inspiromatic Inhaler in Comparison to the Aerolizer Inhaler When Delivering Formoterol
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: PHASE1
PHASE2
Conditions: Asthma
Keywords: asthma
dry powder inhaler
Lead sponsor: Rabin Medical Center
Sponsor class: OTHER
Collaborators: name: Schneider Children's Medical Center, Israel
name: Inspiromedical Inc
First posted: 2012-10-22
Enrollment: 30
Sex: ALL
Minimum age (years): 8
Maximum age (years): 18
Standard ages: CHILD
ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: CROSSOVER
Primary purpose: TREATMENT

Brief summary: Double-blind study, randomized, controlled, and crossover. Study recruited 30 volunteers with stable asthma aged 8-18 years. Participants will perform lung function as part of the routine follow-up then will receive a Foradil 12mcg either with an Aerolizer (a standard dry powder inhaler) or with the Inspiromatic (an active, breath synchronized innovative inhaler). 3-60 days later participants will receive the same drug through the other inhaler.

Pre and post treatment (15 min, 30 min, 60 min) Lung function results, drug levels in the blood, vital signs and side effects will be recorded.


Eligibility criteria: Inclusion Criteria:

* Children 8-18 years with Asthma
* 50\<FEV1\<80
* Can perform Spirometry

Exclusion Criteria:

* Poor cooperation
* Pregnancy
* Milk Allergy
* Other lung disease
* Prior familiarity with Aerolizer

Primary outcomes:
measure: FEV1
timeFrame: We will measure FEV1 post treatment (15 min, 30 min, 60 min)
Secondary outcomes:
measure: Vital signs
timeFrame: Pre treatment and than 15 minutes post treatment
Other outcomes:
measure: Systemic absorption
timeFrame: 0 and 15 minutes post inhaltion
Locations:
city: Petach - Tikva
country: Israel
facility: Schneider Children Hospital
Study officials:
affiliation: Schneider Children Hospital
name: Guy Steuer, M.D.
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT05530486: Effect of the Use of Low Intensity Therapeutic LASER
Official title: Effect of the Use of Therapeutic Low-intensity 660 nm LASER in the Treatment of Diabetic Ulcers: a Double-blind Randomized Clinical Trial
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Wound
Diabetic Foot
LTBI
Keywords: Diabetes Mellitus
Low-Level Light Therapy
Diabetic Foot
Lead sponsor: Federal University of Piaui
Sponsor class: OTHER
First posted: 2022-09-07
Enrollment: 100
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: FACTORIAL
Primary purpose: HEALTH_SERVICES_RESEARCH

Brief summary: Diabetes mellitus consists of a heterogeneous group of metabolic disorders that have hyperglycemia in common, resulting from defects in insulin action, insulin secretion, or both. Diabetes mellitus has gained increasing importance and is considered one of the main themes of global health problems due to the damage caused to quality of life, public health and the epidemiological picture presented. Among the complications are diabetic foot ulcers, with higher prevalence in the lower limbs, they are classified as loss of skin continuity, which can reach from the epidermis to deep structures such as muscles, bones and tendons.

Detailed description: 100 volunteers will be recruited and the research will be carried out through the Integrated Center of Medical Specialties (CIEM) - Polyclinic, through referral from the specialist in vascular surgery after a thorough examination of the feet. Volunteers of both sexes, aged over 18 years, DM and diabetic ulcers will be admitted. Volunteers who present any autoimmune disease, concomitant psychiatric disorders or contraindications to the treatment methods adopted by the research will be excluded. Inclusion in the study will take place after signing the informed consent forms, after approval by the Ethics Committee.

Eligibility criteria: Inclusion Criteria:

* Type 2 diabetes mellitus patients with diabetic foot ulcers;
* Patients aged 18 and over.

Exclusion Criteria:

* Patients with autoimmune diseases
* Patients with concomitant psychiatric disorders
* Patients with contraindications to treatment methods
* Patients with infected diabetic foot ulcers.

Primary outcomes:
measure: Change in the ulcer area
timeFrame: Before intervention starts, 5th and 10th week of intervention.
measure: Change in complete ulcer healing
timeFrame: Before intervention starts, 5th and 10th week of intervention.
Secondary outcomes:
Other outcomes:
Locations:
city: Parnaíba
country: Brazil
facility: Federal University of Piaui
state: Piauí
Study officials:
affiliation: Federal University of Piaui
name: Vinicius Saura Cardoso
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT04032886: Does Mechanical Correction Reduce Muscle Stiffness in People With Rounded Shoulder?
Official title: Does Mechanical Correction Reduce Muscle Stiffness in People With Rounded Shoulder?
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Posture
Keywords: kinesio tape
posture
elastography
Lead sponsor: Aydin Adnan Menderes University
Sponsor class: OTHER
First posted: 2019-07-25
Enrollment: 42
Sex: FEMALE
Minimum age (years): 20
Maximum age (years): 30
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The primary aim of this study is to investigate the effect of mechanical correction taping on the stiffness of the upper trapezius and pectoralis minor muscles in patients with rounded shoulder deformity. The secondary aim of our study was to see whether different tape materials affect the application results.

Detailed description: Mechanical correction technique is a highly preferred method among users. Besides its tactical stimulation it serves like a tool helping to reposition the joints.

Here in this study, the investigators aimed to see the secondary effect of the technique on posture. İt is already known that mechanical correction supports the joints and posture but, the question is; by supporting the upright position does it help the extra loaded muscles to release? As the best way to measure the stiffness of the muscles is Elastography, this study will highlight an important issue about correcting posture and regulate muscle loading.

Eligibility criteria: Inclusion Criteria:

* Ages between 18 and 30 years,
* Sedentary
* Volunteer to enroll in the study,
* To have rounded shoulders,
* To have upper body pain

Exclusion Criteria:

* Professional sports participants
* Musculoskeletal injury during the last 6 months
* Neurologic disorders
* Cervical disc herniation
* To receive physical therapy regarding shoulders in the past 6 months
* Any orthopaedic disorders including impingement, tendinitis, bursitis etc.

Primary outcomes:
measure: change from baseline shearwave elastography stiffness levels to 4 weeks
timeFrame: 4 weeks
measure: change from baseline postural angle degrees to 4 weeks
timeFrame: 4 weeks
measure: change from baseline rounded shoulder measurement to 4 weeks
timeFrame: 4 weeks
Secondary outcomes:
measure: change from baseline Penn shoulder scale total score to 4 weeks
timeFrame: 4 weeks
Other outcomes:
Locations:
city: Aydın
country: Turkey
facility: Aydın Adnan Menderes University
Study officials:
References:
Clinical trial NCT01917786: Effect of Dexmedetomidine on QT Interval in Pediatric Patients Under General Anesthesia
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Surgery
Lead sponsor: Nationwide Children's Hospital
Sponsor class: OTHER
First posted: 2013-08-07
Enrollment: 50
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: CASE_CONTROL
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Patients receiving dexmedetomidine as part of their surgical anesthesia.

Brief summary: Various medications used in anesthesia have been implicated in the prolongation of QT interval. Recently, there has been an increase in the use of dexmedetomidine in patients presenting for surgeries given its beneficial sedative, anxiolytic, and analgesic properties. It has several desirable properties including minimal respiratory side effects as well as the ability to decrease intraoperative and postoperative analgesic requirements. In many of the patients who present for routine surgical procedures, dexmedetomidine is a common component of their anesthetic care. This is a study to assess the effects of dexmedetomidine on the QT interval in children presenting for surgery.


Eligibility criteria: Inclusion Criteria:

* ASA grade 1 or 2.
* Scheduled to receive dexmedetomidine.

Exclusion Criteria:

* Known allergy to dexmedetomidine.

Primary outcomes:
measure: Change in QT interval
timeFrame: Baseline, 5 mins., 10 mins.
Secondary outcomes:
Other outcomes:
Locations:
city: Columbus
country: United States
facility: Nationwide Children's Hospital
state: Ohio
Study officials:
References:
citation: Kako H, Krishna SG, Sebastian R, Smith K, Tobias JD. Effect of dexmedetomidine on the QT interval in pediatric patients undergoing general anesthesia. J Anesth. 2015 Dec;29(6):862-7. doi: 10.1007/s00540-015-2056-2. Epub 2015 Aug 4.
Clinical trial NCT04476186: The Effectiveness of Oral Acyclovir in the Treatment of Molluscum Contagiosum in Children
Official title: The Effectiveness of Oral Acyclovir in the Treatment of Molluscum Contagiosum in Children
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Molluscum Contagiosum
Lead sponsor: Assiut University
Sponsor class: OTHER
Collaborators: name: assistant professor Ghada M. Khafagy
name: Dr. Marwa Diaaeldeen Abbass Hasan
name: Prof. Dr. Emad Taha Abd-Elahim Ebiad
First posted: 2020-07-20
Enrollment: 35
Sex: ALL
Minimum age (years): 2
Maximum age (years): 16
Standard ages: CHILD
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The investigators will study the effectiveness of acyclovir in the treatment of molluscum contagiosum in assiut university hospital - dermatological out patient clinic the treatment group will receive acyclovir 200 mg 5 times per day the controlled group will receive local KOH solution

Detailed description: Study population:

Site of the study: The outpatient dermatological clinic in Assiut university hospital.

Participants: children (2 -16) years' old attending dermatological clinic in Assiut university hospital and their parents.

Methodology in details:

1. We will use the social media as " Facebook" to invite patient to visit the clinic and follow up them due to the protective measures of covid 19.
2. Diagnosis of the patient with molluscum contagiosum according to the clinical picture
3. Collecting data including personal and clinical data through interviewing the patient and his or her parents
4. Pictures of the lesions will be taken before and after treatment after patient consent.
5. We will Randomly assigning the patient to either treatment group or controlled group according to simple random table
6. Prescribing the treatment according to the patient group
7. Follow up of the patient after 1 weak and each week according to the response to treatment or presence of complication

Inclusion criteria:

Children (5 -15) years old with Molluscum contagiosum.

Exclusion criteria:

1. Molluscum contagiosum with Inflamed spot
2. Known immune compromised children
3. Molluscum lesion in the eye lid.
4. Children with renal impairment.

Eligibility criteria: Inclusion Criteria:

* Children (2 -16) years old with Molluscum contagiosum.

Exclusion Criteria:

* Molluscum contagiosum with Inflamed spot Known immune compromised children Molluscum lesion in the eye lid. Children with renal impairment.

Primary outcomes:
measure: The percentage of patient with complete clearance of all molluscum lesions.
timeFrame: 3 month for each participant
Secondary outcomes:
Other outcomes:
Locations:
city: Assiut
country: Egypt
facility: Hamdy Gomaa
state: New Assiut City
Study officials:
affiliation: Cairo University
name: Ghada Mahmoud, Assist Prof
role: PRINCIPAL_INVESTIGATOR
References: