Clinical trial NCT01155258: Temsirolimus and Vinorelbine Ditartrate in Treating Patients With Unresectable or Metastatic Solid Tumors
Official title: Phase I Clinical Trial of Temsirolimus and Vinorelbine in Advanced Solid Tumors.
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE1
Conditions: Extensive Stage Small Cell Lung Cancer
Hereditary Paraganglioma
Male Breast Cancer
Malignant Paraganglioma
Metastatic Gastrointestinal Carcinoid Tumor
Metastatic Pheochromocytoma
Pancreatic Polypeptide Tumor
Recurrent Breast Cancer
Recurrent Cervical Cancer
Recurrent Endometrial Carcinoma
Recurrent Gastrointestinal Carcinoid Tumor
Recurrent Islet Cell Carcinoma
Recurrent Neuroendocrine Carcinoma of the Skin
Recurrent Non-small Cell Lung Cancer
Recurrent Ovarian Epithelial Cancer
Recurrent Ovarian Germ Cell Tumor
Recurrent Pheochromocytoma
Recurrent Prostate Cancer
Recurrent Renal Cell Cancer
Recurrent Small Cell Lung Cancer
Recurrent Uterine Sarcoma
Regional Gastrointestinal Carcinoid Tumor
Regional Pheochromocytoma
Stage III Cervical Cancer
Stage III Endometrial Carcinoma
Stage III Neuroendocrine Carcinoma of the Skin
Stage III Ovarian Epithelial Cancer
Stage III Ovarian Germ Cell Tumor
Stage III Prostate Cancer
Stage III Renal Cell Cancer
Stage III Uterine Sarcoma
Stage IIIA Breast Cancer
Stage IIIA Non-small Cell Lung Cancer
Stage IIIB Breast Cancer
Stage IIIB Non-small Cell Lung Cancer
Stage IIIC Breast Cancer
Stage IV Breast Cancer
Stage IV Endometrial Carcinoma
Stage IV Neuroendocrine Carcinoma of the Skin
Stage IV Non-small Cell Lung Cancer
Stage IV Ovarian Epithelial Cancer
Stage IV Ovarian Germ Cell Tumor
Stage IV Prostate Cancer
Stage IV Renal Cell Cancer
Stage IV Uterine Sarcoma
Stage IVA Cervical Cancer
Stage IVB Cervical Cancer
Thyroid Gland Medullary Carcinoma
Lead sponsor: University of Southern California
Sponsor class: OTHER
Collaborators: name: Wyeth is now a wholly owned subsidiary of Pfizer
First posted: 2010-07-01
Enrollment: 19
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: TREATMENT

Brief summary: RATIONALE: Temsirolimus may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Drugs used in chemotherapy, such as vinorelbine ditartrate, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Giving temsirolimus together with vinorelbine ditartrate may kill more tumor cells.

PURPOSE: This phase I trial is studying the side effects and best dose of giving temsirolimus and vinorelbine ditartrate together in treating patients with unresectable or metastatic solid tumors.

Detailed description: PRIMARY OBJECTIVES:

I. To determine the maximal tolerated dose (MTD) for the combination of temsirolimus and vinorelbine in advanced solid tumors.

II. To obtain preliminary information regarding the activity of this combination.

SECONDARY OBJECTIVES:

I. To evaluate the safety and tolerability of this combination.

OUTLINE:

Patients receive temsirolimus IV over 30-60 minutes on days 1, 8, 15, and 22 and vinorelbine ditartrate IV over 5-10 minutes on days 1 and 15. Courses repeat every 28 days in the absence of disease progression or unacceptable toxicity.

Eligibility criteria: Inclusion

* Patients with histologically confirmed metastatic or unresectable solid tumors for which standard curative measures do not exist or are no longer effective; histology will be limited to those tumors for which temsirolimus or vinorelbine have reported clinical activity: lung, breast, ovary, cervix, prostate, uterus, renal, bladder and neuroendocrine tumors
* SWOG performance status of 0-2
* Projected life expectancy of at least 3 months
* Provision of informed consent prior to any study-related procedures
* Negative pregnancy test for women of childbearing potential
* Female patients must not be pregnant due to the potential mutagenicity and teratogenicity of this treatment; a pregnancy test must be administered 7 days prior to administration of therapy to women of childbearing potential; patients must agree to use some form of contraception while on this study at initiation and for the duration of participation in the study; sexually active males must also use a reliable and appropriate method of contraception; post-menopausal women must be amenorrheic for at least 12 months to be considered of nonchildbearing potential
* Patients must have recovered from acute toxicities from previous surgery, chemotherapy or radiation therapy
* ANC \>= 1500/mm\^3
* Platelet count \>= 100,000 cells/mm\^3
* Hemoglobin \>= 9.0g/dL
* Serum creatinine =\< 1.5 mg/dl
* Hepatic function: Patients must have adequate liver functions: AST or ALT =\< 2.5 X upper limit of normal (ULN), alkaline phosphatase =\< 2.5 X upper limit of normal; in patients with bone metastasis and no evidence of liver metastasis and bilirubin =\< upper limit of normal an alkaline phosphatase =\< 5 ULN will be allowed
* Serum Bilirubin =\< 1.0 mg/dL
* Peripheral neuropathy grade 0-1
* No other concomitant therapy directed at the cancer is allowed

Exclusion

* Prior therapy with vinorelbine or an mTor inhibitor
* Receipt of any investigational agents within 30 days prior to commencing study treatment
* Last dose of prior chemotherapy discontinued less than 4 weeks before the start of study therapy
* Last radiation therapy within the last 4 weeks before the start of study therapy, except palliative radiotherapy
* Any unresolved toxicity greater than CTC grade 1 from previous anticancer therapy, excluding alopecia
* CTC Grade 1 or greater neuropathy (motor or sensory) at study entry
* Hematologic function with absolute neutrophils =\< 1500/mm\^3 and/or platelets \< 100,000/mm\^3
* Hepatic function with serum bilirubin greater than the upper institutional limits of normal, ALT and AST \> 2.5 times the upper institutional limits of normal
* Concurrent use of strong inhibitors of CYP3A4: ketoconazole, itraconazole, ritonavir, amprenavir, indinavir, nelfinavir, delavirdine and voriconazole
* CYP3A4 inducers should be avoided or used with caution; the use of these agents is discouraged: rifabutin, rifampicin, rifapentine, carbamazepine, Phenobarbital, phenytoin and St. John's wart
* Ongoing long term use of steroids for chronic conditions

Primary outcomes:
measure: To determine the maximum tolerated dose of Temsirolimus and Vinorelbine
timeFrame: 1 month up to 18 months
measure: To assess the response rate based on the Response Evaluation Criteria in Solid Tumors (RECIST)
timeFrame: 2 months up to 18 months
Secondary outcomes:
measure: To evaluate the safety and tolerability of Temsirolimus and Vinorelbine
timeFrame: 4 weeks up to 36 weeks
measure: Progression-free and overall survival
timeFrame: Up to 18 months
Other outcomes:
Locations:
city: Los Angeles
country: United States
facility: USC/Norris Comprehensive Cancer Center
state: California
Study officials:
affiliation: University of Southern California
name: Agustin Garcia
role: PRINCIPAL_INVESTIGATOR
References: