Clinical trial NCT05962619: Arthrocentesis Alone Versus Arthrocentesis With Hyaluronic Acid Injection
Official title: Arthrocentesis Alone Versus Arthrocentesis With Hyaluronic Acid Injection in Management of Temporomandibular Joint Dysfunction in the Form of Anterior Disc Displacement With Reduction : a Randomized Controlled Trial
Study type: INTERVENTIONAL
Overall status: NOT_YET_RECRUITING
Phase: NA
Conditions: Temporomandibular Joint Dysfunction Syndrome
Arthrocenteses
Hyaluronic Acid
Lead sponsor: Assiut University
Sponsor class: OTHER
First posted: 2023-07-27
Enrollment: 42
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: CROSSOVER
Primary purpose: TREATMENT

Brief summary: Comparison between Arthrocentesis alone arthrocentesis with hyaluronic acid injection in management of temporomandibular joint dysfunction in the form of anterior disc displacement with reduction.

Detailed description: Temporomandibular joint (TMJ) anterior disc displacement (ADD) is one of the most common TMJ disorders.It can occur in all age groups, with a high prevalence in adolescents .

ADD often presents with clicking, joint pain, a limited range of mouth opening. Furthermore,ADD might lead to osteoarthrosis .

Since ADD of the TMJ can lead to various harmful outcomes, how to manage ADD is considered a key problem for most TMJ experts. It has been difficult for most clinicians to select a suitable method for ADD patients with different grades of severitis ). Initially, these conditions can be managed conservatively by employing techniques such as occlusal splint therapy, physiotherapy, pharmacotherapy and occlusal treatments. If Medical treatment fails, minimally invasive (sodium hyaluronate or corticosteroid infiltrations and arthrocentesis) and invasive treatments (arthroscopy, arthroplasty, arthrotomy, discectomy, condylotomy) are formed ). Sodium hyaluronate is a buffered solution of hyaluronate acid sodium salt, which is an essential component of the cartilage.It acts against the disintegration of the extracellular matrix.It reduces friction, and it features an anti-inflamatory effect. It is indicated for the treatment of osteoarthritic symptoms and inflammatory degenerative joint disease). Intra-articular hyaluronic acid injection provides long-term palliative effects on symptoms and signs of TMJ pain .

Eligibility criteria: Inclusion Criteria:

* Adults with age between( 18-45) years
* Both genders
* The cases ciinically have either of ( limitation of mouth opening , pre-auricular pain , headache, temporal, and occipital tenderness ) and radiologically (MRI) diagnosed as ADD with reduction
* The patients have symptom durations for more than 3 months with medical treatment.
* Patients whom did not respond to medical treatment

Exclusion Criteria:

* Previous TMJ surgery or previous arthrocentesis.
* Patients with arthritis or history of condylar trauma
* Patients with degenerative change of the condylar head and with facial asymmetry, retrognathism, or prognathism
* Severe co-morbid conditions (uncontrolled diabetes, Hypertenion

Primary outcomes:
measure: Mouth opening
timeFrame: Three months
measure: Tempero mandibular joint pain
timeFrame: One month
Secondary outcomes:
measure: Clicking
timeFrame: Three months
Other outcomes:
Locations:
Study officials:
References: