Clinical trial NCT02831465: Dynamic Hyperinflation During Maximal Voluntary Ventilation in Healthy Subjects
Official title: Dynamic Hyperinflation During Maximal Voluntary Ventilation in Healthy Subjects
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Dynamic Hyperinflation
Keywords: Dynamic hyperinflation
Maximal Voluntary Ventilation
Inspiratory capacity
healthy subjects
Lead sponsor: Centre Hospitalier Universitaire Saint Pierre
Sponsor class: OTHER
First posted: 2016-07-13
Enrollment: 45
Sex: ALL
Minimum age (years): 40
Maximum age (years): 69
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: BASIC_SCIENCE

Brief summary: Maximal Voluntary Ventilation (MVV) correlates well with maximal exercise capacity and is used to assess the ventilatory function during exercise in COPD (Chronic Obstructive Pulmonary Disease) patients. Dynamic hyperinflation (DH) often occurs during MVV in COPD and is believed to be due to expiratory flow limitation.

The present study is intended to assess whether DH can also occur during MVV in normal subjects without expiratory flow limitation.

Detailed description: Maximal voluntary ventilation (MVV) correlates well with maximal exercise capacity and is used to assess the ventilatory function during exercise in COPD (Chronic Obstructive Pulmonary Disease) patients. Dynamic hyperinflation (DH) often occurs during MVV in COPD and is believed to be due to expiratory flow limitation. The present study is intended to assess whether DH can also occur during MVV in normal subjects without expiratory flow limitation.

Study design: healthy subjects with normal lung function will perform MVV at increasing breathing frequencies and maximal tidal volume, from 10 to 100 cycles per minute. Inspiratory capacity (IC) will be measured at rest and after each 12 seconds of MVV in order to detect DH. From the moment DH appeares at a given frequency, only one additional MVV at a higher breathing frequency will be conducted to confirm DH.

Eligibility criteria: Inclusion Criteria:

* Healthy subjects

Exclusion Criteria:

* History of asthma, obstructive syndrome on basic lung function

Primary outcomes:
measure: Frequency which induces Dynamic Hyperinflation
timeFrame: day one
Secondary outcomes:
measure: Correlation between the frequency which induces Dynamic Hyperinflation (DH) and Forced Expiratory Volume in one second
timeFrame: day one
measure: Correlation between the frequency which induces Dynamic Hyperinflation (DH) and Forced Vital Capacity
timeFrame: day one
measure: Correlation between the frequency which induces Dynamic Hyperinflation (DH) and Forced Expiratory Flows at 25%, 50% and 75% of Forced Vital Capacity
timeFrame: day one
measure: Correlation between the frequency which induces Dynamic Hyperinflation (DH) and age
timeFrame: day one
measure: Correlation between the frequency which induces Dynamic Hyperinflation (DH) and body mass index
timeFrame: day one
measure: Correlation between the frequency which induces Dynamic Hyperinflation (DH) and Inspiratory Capacity at rest
timeFrame: day one
measure: Correlation between the frequency which induces Dynamic Hyperinflation (DH) and IC/FVC ratio (IC : Inspiratory Capacity at rest ; FVC : Forced Vital Capacity)
timeFrame: day one
measure: Comparison Maximal Voluntary Ventilation with Forced Expiratory Volume in one second multiplied by 35
timeFrame: day one
Other outcomes:
Locations:
city: Brussels
country: Belgium
facility: CHU St. Pierre
state: Brussels Capital Region
Study officials:
affiliation: University Hospital Center Saint Pierre chest service
name: Vincent Ninane, MD, PhD
role: PRINCIPAL_INVESTIGATOR
References: