Clinical trial NCT05533424: Ultrasound Guided Quadratus Lumborum Block Versus Transversus Abdominis Plane Block as Postoperative Analgesia in Patients Undergoing Abdominal Cancer Surgery.
Official title: Ultrasound Guided Quadratus Lumborum Block Versus Transversus Abdominis Plane Block as Postoperative Analgesia in Patients Undergoing Abdominal Cancer Surgery.
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: PHASE3
Conditions: Abdominal Cancer
Lead sponsor: Mansoura University
Sponsor class: OTHER
First posted: 2022-09-09
Enrollment: 98
Sex: ALL
Minimum age (years): 20
Maximum age (years): 80
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: OTHER

Brief summary: Abdominal surgery is usually associated with severe postoperative pain. The transverse abdominal plane (TAP) block is considered an effective means for pain control in such cases. The quadratus lumborum (QL) block is another option for the management of postoperative pain.

The aim of this study is to evaluate the efficacy and safety of quadrates lumborum blocks and Transversus abdominis plane blocks for pain management after abdominal cancer surgery.

Detailed description: Postoperative pain is severe in patients undergoing abdominal surgery, and severe pain not only affects the rate of recovery of patients but also induces a series of pathophysiological reactions. Therefore, it is very important for perioperative patients to have a safe and effective pain management model. Although classic postoperative analgesia methods can provide effective pain relief after surgery, their administration has a well-defined risk of side effects. Recently, with the rise in enhanced recovery after surgery, nerve blocks have become the key link in multimodal analgesic regimes.

As effective constituents of multimode analgesia, quadratus lumborum (QL) block and transversus abdominis plane (TAP) block are mainly used for postoperative analgesia in abdominal surgery.

Aim of this study is to compare between the analgesic effecacy of quadrates lumborum block and transverses abdominal plane block

Eligibility criteria: Inclusion Criteria:

* Patients included in the study, aged 20-60 years,
* with ASA Physical Status Class I and II,
* scheduled for abdominal cancer surgery under general anesthesia

Exclusion Criteria:

* infection at injection site,
* allergy to local anesthetics,
* coagulation disorders,
* physical or mental diseases which could interfere with the evaluation of pain scores
* kidney failure or liver failure.

Primary outcomes:
measure: The total dose of morphine
timeFrame: in the first 24 hours after surgery
Secondary outcomes:
measure: visual analog score
timeFrame: postoperatively at 30 min and 2, 4, 6, 12, and 24 hours
measure: visual analog score
timeFrame: postoperatively 2 hours
measure: visual analog score
timeFrame: postoperatively at 4 hours
measure: visual analog score
timeFrame: postoperatively at 6 hours
measure: visual analog score
timeFrame: postoperatively at 12 hours
measure: visual analog score
timeFrame: postoperatively at 24 hours
Other outcomes:
Locations:
city: Mansoura
country: Egypt
facility: Nevert Adel Abdel Ghaffar
Study officials:
References: