Clinical trial NCT06209437: Anesthesia Management of Coronary Artery Bypass Surgery and Inflammatory Biomarkers
Official title: The Effect of Total Intravenous Anesthesia or Inhalation Anesthesia on Inflammatory Biomarkers in Coronary Artery Bypass Surgery and Their Relationship With Early Postoperative Complications a Prospective Observational Study
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Coronary Artery Disease
Postoperative Complications
Anesthesia
Lead sponsor: Ankara City Hospital Bilkent
Sponsor class: OTHER
First posted: 2024-01-17
Enrollment: 228
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: ASA (American Society of Anesthesiologists) II- III patients over the age of 18 who will undergo on-pump bypass surgery in Ankara City Hospital Bilkent and who agree to participate in the study

Brief summary: The goal of this observational study is to evaluate effect of total intravenous anesthesia or inhalation anesthesia on inflammatory biomarkers in coronary artery bypass surgery and their relationship with early postoperative complications. The main questions it aims to answer are

* Does the type of anesthesia have a relationship with inflammatory biomarkers?
* Are inflammatory biomarkers associated with postoperative complications?

Detailed description: This study is planned to be a prospective observational clinical study. Patients who will undergo on-pump coronary artery bypass surgery, meet the eligibility criteria and agree to participate in the study and sign the informed patient consent form will be included in the study.Systemic immune inflammatory index, systemic inflammatory response index, neurophile lymphocyte ratio, platelet lymphocyte ratio will be calculated in the routine complete blood count of patients in the last 3 preoperative days and in the first 24 hours postoperatively.It will be evaluated whether these biomarkers are related to the anesthesia technique used, patients comorbidities and the complications that develop in the first 24 hours postoperatively. Patients will be evaluated preoperatively, intraoperatively and postoperatively; preoperative comorbidities, intraoperative anesthesia management, cross clamp, pump and surgery times, blood and blood product transfusion, inotrope use and complications that develop up to the first 24 hours postoperatively will be recorded.The anesthetic technique to be used will be determined according to the anesthesiologist's preference and will be recorded.

Eligibility criteria: Inclusion Criteria:

* On-pump bypass surgery
* Del-Nido cardioplegia used in operation
* ASA (American Society of Anesthesiologists) II- III patients

Exclusion Criteria:

* Patients with active malignancy
* Diagnosed with systemic inflammatory disease or autoimmune disease
* Chronic liver and kidney disease
* History of cerebrovascular disease within 6 months
* EF (Ejection Fraction) \< 45%
* Non-cooperative or patients who do not agree to participate in the study

Primary outcomes:
measure: Preoperative systemic immune inflammatory index (SII)
timeFrame: within 3 days preoperatively
measure: Postoperative systemic immune inflammatory index (SII)
timeFrame: in the first 24 hours postoperatively
measure: Preoperative systemic inflammatory response index (SIRI)
timeFrame: within 3 days preoperatively
measure: Postoperative systemic inflammatory response index (SIRI)
timeFrame: in the first 24 hours postoperatively
measure: Preoperative neutrophile lymphocyte ratio (NLR)
timeFrame: within 3 days preoperatively
measure: Postoperative neutrophile lymphocyte ratio (NLR)
timeFrame: in the first 24 hours postoperatively
measure: Preoperative platelet lymphocyte ratio (PLR)
timeFrame: within 3 days preoperatively
measure: Postoperative platelet lymphocyte ratio (PLR)
timeFrame: in the first 24 hours postoperatively
measure: Preoperative c-reactive protein
timeFrame: within 3 days preoperatively
measure: Preoperative procalcitonin
timeFrame: within 3 days preoperatively
measure: Postoperative c-reactive protein
timeFrame: in the first 24 hours postoperatively
measure: Postoperative procalcitonin
timeFrame: in the first 24 hours postoperatively
measure: Postoperative complications
timeFrame: within the first 24 hours after surgery
Secondary outcomes:
measure: Patient comorbidities
timeFrame: preoperative within 48 hours
measure: Transfusion requirement
timeFrame: during the operation
measure: Inotrope requirement
timeFrame: during the operation
Other outcomes:
Locations:
city: Ankara
country: Turkey
facility: Ankara city hospital bilkent
state: Çankaya
Study officials:
References: