Clinical trial NCT04836715: Prevalence of Visual Dysfunction in Neurological Disorders
Official title: Prevalence of Visual Dysfunction in Persons With Parkinson's Disease and Other Neurological Disorders
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Parkinson Disease
Other Neurological Disorders
Healthy
Lead sponsor: University of Florida
Sponsor class: OTHER
First posted: 2021-04-08
Enrollment: 92
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Observational model: OTHER
Time perspective: OTHER
Sampling method: NON_PROBABILITY_SAMPLE
Study population: 1. Persons with Parkinson's Disease
2. Persons without a Neurological Condition (Controls)
3. Persons with Other Neurological Conditions (e.g. ALS, TBI, MS, CBT/CBS, MSA, PSP, MCI, etc).

Brief summary: The objective is to determine the prevalence of visual dysfunction in People with Parkinson's Disease (PwP). The investigators will administer the: Visual Impairment in Parkinson's Disease Screen and Revised-Self-Report Assessment of Functional Visual Performance. Patients seen at Fixel Institute and their caregivers will be invited to participate. Responses to the 2 questionnaires will help determine prevalence rates of visual dysfunction in PwP compared to those both with and without other neurological conditions.

Detailed description: The purpose of this study is to identify the prevalence of visual dysfunction among Persons with Parkinson's Disease, compared to other neurological conditions and controls without neurological conditions.

Data will be collected anonymously via RedCap. Patients seen at the Fixel Institute that have consented to be contacted regarding research opportunities will be recruited via blast email and advertisement in our Institute's monthly newsletter, the Movement Messenger. The email and newsletter will contain a link for participation in surveys within RedCap so the surveys can be completed anonymously at home. Participation will be completely voluntary and responses will be recorded anonymously. Data will include responses to the following: screening questions, the VIPDQ (Visual Impairment in PD Questionnaire), and the R-SRAFVP (Revised-Self-Report Assessment of Functional Visual Performance).

The investigators will calculate the prevalence of visual impairment (from the VIPDQ) and dysfunction in performance of daily activities (from the R-SRAFVP) for PwP and compare this to the prevalence occurring in other neurological populations as well as the population without any neurological conditions. Other data are collected so the investigators can then evaluate potential confounds or covariates. To ensure statistical methods are accurate, a statistician will be consulted.

Eligibility criteria: Inclusion Criteria:

* Persons with Parkinson's Disease: Confirmed diagnosis of Parkinson's Disease without presence of any other neurological condition.
* Persons without Parkinson's Disease (Controls): No previous diagnosis of any neurological condition
* Persons with a single other neurological disorder (Neuro Controls): Confirmed diagnosis of other neurological condition (e.g. ALS, multiple sclerosis, essential tremor, ataxia, etc).

Exclusion Criteria:

* Children (ages younger than 18 years of age)
* Persons with more than one diagnosed neurological condition.

Primary outcomes:
measure: Visual Dysfunction
timeFrame: 1 day
measure: Functional Visual Performance
timeFrame: 1 day
Secondary outcomes:
Other outcomes:
measure: Correlations between Visual Dysfunction and Functional Visual Performance
timeFrame: 1 day
Locations:
city: Gainesville
country: United States
facility: UF Health Rehab - Fixel Institute
state: Florida
city: Gainesville
country: United States
facility: University of Florida
state: Florida
Study officials:
affiliation: University of Florida/UF Health Rehab
name: Nicole J Tester, PhD, MOT, OTR/L, MSCS
role: PRINCIPAL_INVESTIGATOR
References: