Clinical trial NCT07018817: Hypoxia Adaptation Promotes Cerebral Functional Connectivity With Neuromuscular Efficiency Decrement
Official title: A Trimodal Study on Hypoxia Adaptation: Promotion of Cerebral Functional Connectivity and Decrement of Neuromuscular Efficiency
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Hypoxia
Altitude Sickness
Keywords: Brain
Lead sponsor: Peking Union Medical College
Sponsor class: OTHER
First posted: 2025-06-13
Enrollment: 80
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: CASE_CONTROL
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: Short-term migration from the highlands

Brief summary: The study utilized a trimodal setup comprising EEG, EMG, and fNIRS modules. Participants wore a 64-channel dry EEG cap, while EMG electrodes were placed on the right biceps brachii, the flexor digitorum profundus of the forearm, and the gastrocnemius muscle. fNIRS probes were positioned on the forehead to monitor cerebral hemodynamic responses.

The experimental paradigm included two tasks: motor execution (ME) and motor imagery (MI). During ME, participants performed 15 trials of actual movements. In MI, participants completed 60 trials of imagined movements. Each trial involved a randomly presented stimulus-left-hand clenching, right-hand clenching, or bilateral heel raising-with each movement type occurring an equal number of times across the session.

Detailed description: This study employed a multimodal acquisition system comprising EEG, EMG, and fNIRS modules. Participants were fitted with a 64-channel dry EEG cap for the measurement of cortical electrical activity. Surface EMG electrodes were attached to three muscle groups: the right biceps brachii, the flexor digitorum profundus of the forearm, and the gastrocnemius muscle, to record muscle activation signals. Simultaneously, fNIRS probes were positioned on the participants' foreheads to monitor cerebral hemodynamic responses.

The experimental paradigm was divided into two tasks: motor execution (ME) and motor imagery (MI). During the ME task, participants performed 15 trials of actual movements, whereas the MI task involved 60 trials of imagined movements. Each trial randomly presented one of three stimuli-left-hand clenching, right-hand clenching, or bilateral heel raising-with an equal distribution of the three movement types across the session. The order of stimuli was randomized to prevent prediction bias.

Eligibility criteria: Inclusion Criteria:

* People who can withstand altitude sickness

Exclusion Criteria:

* Plateau Native

Primary outcomes:
measure: EEG Power Spectrum in Motor Imagery and Motor Execution Tasks
timeFrame: up to 2 weeks
Secondary outcomes:
measure: Surface EMG Amplitude of Upper Limb Muscles during Motor Tasks
timeFrame: up to 2 weeks
measure: Cerebral Oxygenation Measured by Near-Infrared Spectroscopy (NIRS) in Prefrontal Cortex
timeFrame: up to 2 weeks
Other outcomes:
Locations:
city: Tianjin
country: China
facility: Institute of Biomedical engineering，Chinese Academy of Medical Sciences & Peking Union Medical College
state: Tianjin
Study officials:
References: