Clinical trial NCT04583696: The Investigation of Effect on Blood Lipid Parameters With Walnut Addition of Diet
Official title: The Investigation of Effect on Blood Lipid Parameters With Walnut Addition of Diet
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Cardiovascular Risk Factor
Keywords: cholesterol
walnut consumption
small dense LDL
blood lipids
dietary fiber
Lead sponsor: Ege University
Sponsor class: OTHER
Collaborators: name: Sifa University
First posted: 2020-10-12
Enrollment: 30
Sex: ALL
Minimum age (years): 18
Maximum age (years): 35
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: BASIC_SCIENCE

Brief summary: Introduction There is a strong relationship between eating habits and diseases of the cardiovascular system. It is known that walnut consumption has positive effects on cardiovascular system diseases. However, its effect on small dense LDL (sdLDL) is discussed. Therefore in this study, you participated the effects of walnut consumption on the serum lipids values, especially sdLDL values of healthy volunteers.

Methods Volunteers participating in this study were offered 30 grams of walnuts per day for 21 days. Walnuts were consumed on empty stomach or with breakfast every morning for 21 days. The blood values of subjects were measured at the beginning and the end of the study. The serum was obtained from the taken blood and blood lipid/hemoglobin parameters were measured on routine blood work. Food consumption records and surveys were taken from individuals.


Eligibility criteria: Inclusion Criteria:

* Do not consume any products such as nuts and walnuts (the frequency of consumption should not be more than once a week)
* Have no allergies to foods such as nuts and walnuts
* Do not take drugs on a daily and continuous basis

Exclusion Criteria:

* Obesity
* Diabetes Mellitus
* Acoholic and chronic diseases such as kidney
* Thyroid
* Hepatitis
* Cancer etc.

Primary outcomes:
measure: Blood from the participants was collected before and at the end of the study. Later in this study, sdLDL levels of blood taken from participants were measured by the Elisa method.
timeFrame: Within research completion, an average of 2 week
measure: Blood from the participants was collected before and at the end of the study. Later, the serum lipids of the blood taken from the participants consuming walnuts were measured in the hospital.
timeFrame: The first day of the research and the end day (3 weeks later) were analyzed.
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
References:
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citation: Bamberger C, Rossmeier A, Lechner K, Wu L, Waldmann E, Stark RG, Altenhofer J, Henze K, Parhofer KG. A Walnut-Enriched Diet Reduces Lipids in Healthy Caucasian Subjects, Independent of Recommended Macronutrient Replacement and Time Point of Consumption: a Prospective, Randomized, Controlled Trial. Nutrients. 2017 Oct 6;9(10):1097. doi: 10.3390/nu9101097.