Clinical trial NCT04362215: Heart Aging When Near Vision Difficulty Begins
Official title: Heart Aging When Near Vision Difficulty Begins
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Aging
Keywords: aging
heart aging
presbyopia
Lead sponsor: Kecioren Education and Training Hospital
Sponsor class: OTHER
First posted: 2020-04-24
Enrollment: 500
Sex: ALL
Minimum age (years): 49
Maximum age (years): 51
Standard ages: ADULT
Accepts healthy volunteers: yes
Observational model: CASE_CONTROL
Time perspective: CROSS_SECTIONAL
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Healthy Volunteers ,mean 50 years of age (49-51)

Brief summary: Near vision deterioration during aging results from a decrease in accomodation amplitude (AA). Myocardial regeneration is limited, and cardiac aging is an independent risk factor for cardiovascular disease. Thus, the investigators investigated the association between cardiac aging and AA.

The subjects (500, mean 50-year-old subjects, with equal males and females) were divided into two groups according to AA measured with a Raf ruler. Biomicroscopy was used to capture images of the lens nucleus in the unaccommodated state, followed by images of a 4 diopter (D) accommodated state. The nucleus diameter change at 1 D accomodation was measured using ImageJ. Cardiac conduction system differences were evaluated using electrocardiography, and cardiac autonomic aging was assessed based on heart rate variability. Myocardial aging was assessed based on diastolic dysfunction.

Detailed description: Lens cells and proteins are encapsulated, and they are not turned over or replaced.The lens nucleus starts to form before birth, so the nucleus is one of the three oldest tissues in the body .With aging, continuous cardiomyocyte stress derails proteostasis by causing excessive autophagy and protease activation, and, ultimately, contractile and electrophysiological dysfunction. Aggregate deposition, proteostasis deterioration, and diffusion degradation between the nucleus and cortex are the main reasons for lens aging.Heart, lens, and neuronal cells change significantly with age, and they are older than cells from renewable tissues.

Near vision deterioration during aging results from a decrease in accomodation amplitude (AA). Cardiac aging is an independent risk factor for cardiovascular disease. Thus, the investigators investigated the association between cardiac aging and AA. The subjects (500 mean 50-year-old subjects, with equal males and females) were divided into two groups according to AA measured with a Raf ruler. The nucleus diameter change at 1 D accomodation was measured using ImageJ. Cardiac conduction system differences, autonomic aging, myocardial aging were evaluated using electrocardiography, heart rate variability and diastolic dysfunction. For near distance vision,compared to subjects who could see clearly from 24-28 cm, subjects who could see clearly from 29-33 cm had a 2.104-fold higher risk of a lateral e' velocity \<10 cm/s\[95%CI; 1.312-3.374\], 2.603-fold higher risk of diastolic dysfunction\[95%CI; 1.453-4.662\], 1.54-fold higher risk of a low/high frequency ratio \>3.1, \[95%CI;1.085-2.197\]. Subjective AA measurement can predict important heart aging parameters.

Eligibility criteria: Inclusion Criteria:

Healthy Volunteers, mean 50 years of age (49-51)

Exclusion Criteria:

Hypertension, Diabetes mellitus, Atrial fibrillation, Coronary artery disease, Arrhythmia, Hyperthyroidism , Anemia, Heart failure, Respiratory diseases, Severe obesity (body mass index ≥35 kg/m2),

Primary outcomes:
measure: ECG interval changes meauserements(ms,mm,number)
timeFrame: 1 day
measure: Holter implementation
timeFrame: 1 day
measure: Echocardiographic measurements
timeFrame: 1 day
Secondary outcomes:
Other outcomes:
Locations:
city: Ankara
country: Turkey
facility: ANkara Keçiören EAH
Study officials:
affiliation: University of Health Sciences Ankara Keçiören Education Hospital
name: Şahbender Koç
role: PRINCIPAL_INVESTIGATOR
References:
citation: Koc S, Baysal SS. Heart aging when near vision difficulty begins. Aging Male. 2020 Dec;23(5):1346-1354. doi: 10.1080/13685538.2020.1766438. Epub 2020 May 25.