Clinical trial NCT05945134: Sit-to-stand Training With Interactive Feedback in Chronic Stroke
Official title: Effects of Sit-to-stand Training With Interactive Feedback on Muscle Contraction Sequences and Weight Bearing Symmetry in Individuals With Chronic Stroke
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Stroke
Keywords: Interactive feedback
Muscle contraction sequence
Weight bearing symmetry
Sit-to-stand training
Chronic stroke
Lead sponsor: National Yang Ming Chiao Tung University
Sponsor class: OTHER
First posted: 2023-07-14
Enrollment: 20
Sex: ALL
Minimum age (years): 20
Maximum age (years): 80
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The major problems of people with chronic stroke include muscle weakness, sensory alteration, and inter-muscular coordination impairment. Inter-muscular coordination impairment caused altered muscle contraction sequences and weight-bearing asymmetry during functional activities. Sit-to-stand (STS) training is often used to improve functional activities among post-stroke subjects. However, the improvement may come from compensatory movements. Using compensatory movement may cause muscle weakness in the affected side and increase fall risk. This study will develop a novel STS training system with interactive visual and audio feedback emphasizing weight transferring and weight bearing. The present study aims to investigate the effects of sit-to-stand training with interactive visual and audio feedback on muscle contraction sequences and weight bearing symmetry in individuals with chronic stroke.

Detailed description: This is a prospective randomized single-blinded controlled trial with pre- and post-measurements. 20 individuals will be recruited, and randomly assigned to experimental or control group. Statistical data analysis will be done by SPSS 24.0. Baseline characteristics will be analyzed using independent t-test or Chi-square test. Repeated measures two-way analysis of variance (ANOVA) with Tukey's post-hoc analysis will be used for time-by-group comparisons. The significant level is set at 0.05.

Eligibility criteria: Inclusion Criteria:

* Diagnosis of stroke ≥ 6 months
* Mini-mental state examination (MMSE) ≥ 24 points
* Brunnstrom lower limb recovery stage: ≥ stage 3
* Be able to independently perform STS for at least 10 times
* Single STS \>1.7 seconds
* Be able to walk ≥10 meters independently

Exclusion Criteria:

* Any other musculoskeletal, neurological and cardiovascular diseases
* Have visual or language impairments

Primary outcomes:
measure: Sit to stand performance: change in onset time of muscle contraction sequences
timeFrame: 5 minutes, Change from baseline onset time at 3-week post-test
measure: Sit to stand performance: change in peak force time of muscle contraction sequences
timeFrame: 5 minutes, Change from baseline peak force time at 3-week post-test
measure: Sit to stand performance: change in offset time of muscle contraction sequences
timeFrame: 5 minutes, Change from baseline offset time at 3-week post-test
measure: Sit to stand performance: change in weight bearing symmetry
timeFrame: 5 minutes, Change from baseline weight bearing symmetry at 3-week post-test
measure: Sit to stand performance: change in COP sway pathway
timeFrame: 5 minutes, Change from baseline COP sway pathway at 3-week post-test
Secondary outcomes:
measure: Sit to stand performance: change in sit to stand duration
timeFrame: 5 minutes, Change from baseline sit to stand duration at 3-week post-test
measure: Gait performance: change in symmetry of gait speed
timeFrame: 5 minutes, Change from baseline symmetry of gait speed at 3-week post-test
measure: Gait performance: change in symmetry of step length
timeFrame: 5 minutes, Change from baseline symmetry of step length at 3-week post-test
measure: Gait performance: change in symmetry of step time
timeFrame: 5 minutes, Change from baseline symmetry of step time at 3-week post-test
Other outcomes:
Locations:
city: Taipei
country: Taiwan
facility: National Yang Ming Chiao Tung University
Study officials:
affiliation: rywang@nycu.edu.tw
name: Ray-Yau Wang, PhD
role: PRINCIPAL_INVESTIGATOR
References: