Clinical trial NCT04906148: Young Adults' Reactions to Low Nicotine Cigarette Advertising
Official title: Young Adults' Reactions to Low Nicotine Cigarette Advertising
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Smoking
Keywords: low nicotine
Lead sponsor: Abramson Cancer Center at Penn Medicine
Sponsor class: OTHER
Collaborators: name: National Cancer Institute (NCI)
First posted: 2021-05-28
Enrollment: 56
Sex: ALL
Minimum age (years): 21
Maximum age (years): 29
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: FACTORIAL
Primary purpose: OTHER

Brief summary: Reducing the nicotine content in combustible cigarettes to non-addictive levels has demonstrated promise as a safe and effective public health strategy for decreasing tobacco-caused morbidity and mortality. Little data are available, however, assessing how the marketing of low nicotine content (LNC) cigarettes could dampen their potential population health benefit. This study will examine LNC cigarette advertising content effects on message recall, viewing patterns, product perceptions, and use behaviors. Young adults (N = 340; 170 smokers, 170 non-smokers) will complete a single-session laboratory study using a 2 x 2 between-subject design to manipulate advertisement messaging accuracy (true vs. false/misleading) and content (implicit vs. explicit). Findings may be used to guide public health policy decisions related to regulating cigarette nicotine content and marketing.


Eligibility criteria: Inclusion Criteria:

* Aged 21-29
* Able to use a computer or related technology (such as a smartphone or tablet) with reliable internet access and willing to use the device to participate in the research study.
* Have a valid email address and willing to use email to participate in the research study. Participants without an existing email account who are willing to create one for study purposes are eligible to participate.

Additional inclusion criteria vary by smoking status.

Exclusion Criteria:

* Currently enrolled in a cessation program
* Report consuming ≥ 25 alcohol-containing drinks per week
* Report a history or current psychiatric diagnosis or severe medical condition
* Are color-blind or have another visual impairment (e.g., partial blindness, uncorrected cataract)
* Self-report being pregnant and/or lactating
* Are diagnosed with or test positive for COVID-19. Participants who report having traveled to a high-risk area in the past 2 weeks or who have been in close contact with someone confirmed or being evaluated for COVID-19 will be placed on a waitlist. Waitlisted participants will be asked to self-isolate for 14 days after exposure (even without symptoms) and will be re-screened for eligibility post self-isolation.

Additional, general reasons for exclusion include:

* Significant non-compliance with protocol and/or study design as determined by the Principal Investigator (PI) at any point throughout the study.
* Past, current, anticipated, or pending enrollment in another research program over the study period that could potentially impact study data as determined by the PI.
* Any medical condition, illness, disorder, adverse event (AE), or concomitant medication that could compromise participant safety or significantly impact study performance as determined by the PI. Subjects may be deemed ineligible for any of the aforementioned reasons at any point throughout the study, as well as during the initial telephone screen.

Primary outcomes:
measure: Attention
timeFrame: Day 0
measure: Risk beliefs
timeFrame: Day 0
measure: Recall
timeFrame: Day 0
measure: Perceived health risks
timeFrame: Day 0
Secondary outcomes:
measure: Purchasing behavior
timeFrame: Day 0
measure: Attitudes
timeFrame: Day 0
Other outcomes:
Locations:
city: Philadelphia
country: United States
facility: Center for Interdisciplinary Research on Nicotine Addiction, University of Pennsylvania
state: Pennsylvania
Study officials:
affiliation: University of Pennsylvania
name: Andrew Strasser, PhD
role: PRINCIPAL_INVESTIGATOR
References: