Clinical trial NCT06405737: Oxytocin's Effect on the Advantageous- and Disadvantageous-inequity
Official title: Oxytocin Modulates the Processing of the Advantageous- and Disadvantageous-inequity
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Healthy
Keywords: advantageous inequity
disadvantageous inequity
fMRI
oxytocin
Lead sponsor: University of Electronic Science and Technology of China
Sponsor class: OTHER
First posted: 2024-05-08
Enrollment: 80
Sex: MALE
Minimum age (years): 18
Maximum age (years): 30
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: BASIC_SCIENCE

Brief summary: The main aim of the study is to investigate whether intranasal oxytocin modulates advantageous- and disadvantageous-inequity and whether oxytocin has similar effects on them or not.

Detailed description: The main aim of the study is to investigate whether intranasal oxytocin modulates advantageous- and disadvantageous-inequity and its underlying neural mechanisms and whether oxytocin has similar effects on them or not. A double-blinded, placebo-controled, between-subject design is employed in this study. In a randomized order, a total of 80 healthy males are instructed to self-administrated intranasal spray of oxytocin or placebo. A modified inequity decision-making task starts 45 minutes after treatment with behavioral (fairness rating, preference rating and the choice rate of unequal option) and fMRI data being collected during this task. Personality traits of subjects are assessed using validated Chinese version questionnaires including the Beck Depression Inventory (BDI-II), State-Trait Anxiety Inventory (STAI), Autism Spectrum Quotient (ASQ), Sensitivity to Punishment and Sensitivity to Reward Questionnaire (SPSRQ), Behavioral Inhibition System and Behavioral Activation System Scale (BIS/BAS). Subjects are asked to complete Positive and Negative Affect Schedule (PANAS) when they just arrive, before and after the task.

Eligibility criteria: Inclusion Criteria:

* Healthy subjects without past or current psychiatric or neurological disorders

Exclusion Criteria:

* history of head injury
* pregnant,menstruating,taking oral contraceptives
* medical or psychiatric illness.
* excessive head movement (\> 3mm) during scanning

Primary outcomes:
measure: Behavioral index: fairness rating scores
timeFrame: 45-75 minutes after treatment administration
measure: Behavioral index: preference rating scores
timeFrame: 45-75 minutes after treatment administration
measure: Neural indices: fMRI-based measures of the outcome presentation stage
timeFrame: 45-75 minutes after treatment administration
Secondary outcomes:
measure: Behavioral index: choice rate of unequal option
timeFrame: 45-75 minutes after treatment administration
measure: Neural indices: fMRI-based measures of outcome and re-decision stages
timeFrame: 45-75 minutes after treatment administration
Other outcomes:
Locations:
city: Chengdu
country: China
facility: University of Electronic Science and Technology of China (UESTC)
state: Sichuan
Study officials:
affiliation: University of Electronic Science and Technology of China
name: Yao Shuxia, Dr
role: PRINCIPAL_INVESTIGATOR
References: