Clinical trial NCT03756363: The Effect of Solvent Usage on Post-treatment Pain
Official title: Postoperative Pain After Removal of Gutta-percha From Root Canals in Endodontic Retreatment Using a Solvent
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Root Canal Infection
Pain
Keywords: Postoperative pain
Debris extrusion
Filling removal
solvent
Lead sponsor: Yuzuncu Yıl University
Sponsor class: OTHER
First posted: 2018-11-28
Enrollment: 90
Sex: ALL
Minimum age (years): 18
Maximum age (years): 60
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: No clinical evidence has been yet published regarding the comparison of postoperative pain after removal of the root canal fillings with or without solvent. The aim of this study was to evaluate the effect of combined usage of ProTaper retreatment instruments and a gutta-percha solvent, on the postoperative pain intensity after retreatment.

Detailed description: Scientific literature contains a few studies regarding the amount of apically extruded debris caused by solvent or solvent free use of rotary instruments. It was reported that the use of ProTaper retreatment instruments in combination with gutta-percha solvent reduced the amount of apically extruded debris compared to their solvent free use. Nevertheless,no clinical evidence has been yet published regarding the comparison of postoperative pain after removal of the root canal fillings with or without solvent. The aim of this study was to evaluate the effect of combined usage of ProTaper retreatment instruments and gutta-percha solvent, on the postoperative pain intensity after retreatment. The adult patients (18-59 ages) who referred to Department of Endodontics with a diagnose of failed root canal treatment were examined radiographically and clinically. Endodontically treated, clinically asymptomatic, single-rooted teeth with one canal exhibiting chronic periapical infection were included. A hundred cases who matched the determined criteria were selected and randomly allocated to two groups:

Non-solvent Group (n=50):

ProTaper retreatment instruments were used in combination with with X-Smart electric motor for the removal of root canal fillings.

Solvent Group (n=50):

ProTaper retreatment instruments were used with the abovementioned technique but in combination with a gutta-percha solvent

Eligibility criteria: Inclusion Criteria:

* Systemically healthy patient who has a failed root canal treatment.
* Asymptomatic single rooted teeth that had an initial root canal filling diagnosed with chronic apical periodontitis.
* Patients agreed to parcitipate in the study

Exclusion Criteria:

* Overfilled teeth,
* teeth with intraradicular posts,
* existence of a sinus tract,
* consumption of antibiotics or analgesics within one month,
* pregnancy,
* history of trauma,
* traumatic occlusion

Primary outcomes:
measure: Postoperative pain after removal of gutta-percha with or without solvent
timeFrame: 24 hours postoperatively
Secondary outcomes:
measure: Postoperative pain after removal of gutta-percha with or without solvent
timeFrame: 24 to 48 hours postoperatively
measure: Postoperative pain after removal of gutta-percha with or without solvent
timeFrame: 48 to 72 hours postoperatively
Other outcomes:
Locations:
city: Van
country: Turkey
facility: Ozgur Genc Sen
Study officials:
affiliation: Yuzuncu Yil University, Faculty of Dentistry
name: Ozgur G Genc Sen
role: PRINCIPAL_INVESTIGATOR
affiliation: Yuzuncu Yil University, Faculty of Dentistry
name: Ali G Erdemir
role: STUDY_DIRECTOR
References:
citation: Genc Sen O, Erdemir A, Canakci BC. Effect of solvent use on postoperative pain in root canal retreatment: a randomized, controlled clinical trial. Clin Oral Investig. 2020 Jan;24(1):257-263. doi: 10.1007/s00784-019-02948-3. Epub 2019 May 15.