Clinical trial NCT01500759: Sleep-Disordered Breathing in Heart Failure - The SchlaHF-Registry
Official title: Prevalence, Clinical Characteristics and Type of Sleep-disordered Breathing in Patients With Chronic, Symptomatic, Systolic Heart Failure
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Congestive Heart Failure
Left Ventricular Systolic Dysfunction
Keywords: chronic heart failure
heart failure
hf
sleep-disordered breathing
sdb
nyha
lvef
cheyne stokes
central sleep apnoea
sleep apnoea
Lead sponsor: ResMed
Sponsor class: INDUSTRY
First posted: 2011-12-28
Enrollment: 6876
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: Adult patients with Chronic Heart Failure with LVEF ≤ 45% and NYHA III-IV or NYHA class II with at least one hospitalisation for HF in the last 24 months.

Brief summary: Objective target of the registry is to investigate the prevalence of SDB as well as the clinical characteristics of patients with and without SDB as well as the predominant type of sdb.

For this purpose data from patients suffering from chronic, symptomatic heart failure with impaired left ventricular ejection fraction will be collected prospectively.

Detailed description: Despite recent advances in pharmacological treatment, congestive heart failure (CHF) continues to cause debilitating symptoms, frequent hospital admissions and a high mortality. Despite of therapy with beta-blockers and ACE-inhibitors many patients have persistent symptoms and most will eventually die of cardiovascular causes, often from progressive heart failure.

Sleep Disordered Breathing (SDB) is known to cause consequences, which have negative effects on heart failure.

Objective target of the registry is to investigate the prevalence of SDB, clinical characteristics, symptoms and the degree and type of SDB in patients with chronic HF.

For this purpose data from patients with chronic heart failure will be collected prospectively.In the registry several cardiologists in private practice or hospital and cooperating sleep laboratories shall participate.

Cardiologists screen patients with Chronic Heart Failure (chronic HF) prospectively. In case of suffering from chronic HF for at least 12 weeks since diagnosis, with NYHA III-IV or NYHA class II with at least one hospitalisation for HF in the last 12 months. Written informed consent for data privacy aspects must be obtained before screening for SDB. Patients who satisfy to all inclusion- and exclusion criteria will be included consecutively into the registry.

Eligibility criteria: Inclusion Criteria:

* Patients must be over 18
* Chronic heart failure (at least 12 weeks since diagnosis) according to the current applicable guidelines
* Left ventricular systolic dysfunction (LVEF ≤ 45% by imaging method such as echocardiography, radionuclide angiography, left ventriculography, or cardiac magnetic resonance imaging) documented less than 12 weeks
* NYHA class III or IV at the time of inclusion or NYHA class II with at least one hospitalisation for HF in the last 24 months
* Patient is able to fully understand study information and signed informed consent

Exclusion Criteria:

* Life expectancy \< 1 year for diseases unrelated to chronic HF
* Cardiac surgery, Percutaneous coronary intervention (PCI), Myocardial Infarction (MI) or unstable angina within 6 months
* CRT-implantation (either CRT-D or CRT-P) scheduled or within 6 months
* Transient ischemic attack (TIA) or Stroke within 3 months
* Hemodynamically significant uncorrected primary valvular heart disease, obstructive or regurgitant, or any valvular disease expected to lead to surgery
* Acute myocarditis/pericarditis within 6 months
* Current CPAP or bilevel therapy

Primary outcomes:
measure: Prevalence of SDB in Chronic HF Patients
timeFrame: 1 night: Patients fulfilling the inclusion and exclusion criteria were examined for sleep-disordered breathing during 1 night in a sleep facility
Secondary outcomes:
measure: Left Ventricular Ejection Fraction
timeFrame: 1 night: Patients fulfilling the inclusion and exclusion criteria were examined for LVEF in a medical institution
measure: Age
timeFrame: 1-time single assessment at baseline
measure: Body Mass Index
timeFrame: 1-time single assessment at baseline
measure: Male Gender
timeFrame: 1-time single assessment at baseline
measure: NYHA Class ≥III
timeFrame: At baseline, the NYHA was determined in a medical institution or taken restrospectively from medical records
measure: Ischemic Etiology
timeFrame: 1-time: At baseline the ischemic etiology was determined in the medical institution or taken retrospectively from the medical records.
measure: Atrial Fibrillation
timeFrame: 1-time: At baseline atrial fibrillation (AF) was determined in the medical institution or AF history was taken retrospectively from the medical records
measure: Nocturnal Dyspnea
timeFrame: 1-time: At baseline history of nocturnal dyspnea taken retrospectively from the medical records
measure: Nocturia ≥3 Times/Night
timeFrame: 1-time: At baseline nocturia was assessed 1 time (anamnesis)
measure: Apnoea-Hypopnea-Index
timeFrame: 1 night: Apnoea-Hypopnea Index (AHI) was assessed during one night under polysomnography (PSG) in a sleep facility
measure: Oxygen Desaturation Index
timeFrame: 1 time: Oxygen desaturation Index (ODI) was assessed during one night under polysomnography (PSG) in a sleep facility
measure: Mean SpO2
timeFrame: 1 night: oxygen saturation was assessed during one night under polysomnography (PSG) in a sleep facility
measure: Min SpO2
timeFrame: 1 night: Minimum saturation with oxygen was assessed during one night under polysomnography (PSG) in a sleep facility
measure: Medication ACE Inhibitors and/ARBs
timeFrame: 1-time: At baseline medication was assessed 1 time (anamnesis)
measure: Beta-blocker
timeFrame: 1-time: At baseline medication was assessed 1 time (anamnesis)
measure: Diuretics
timeFrame: 1-time: At baseline medication was assessed 1 time (anamnesis)
measure: Digitalis
timeFrame: 1-time: At baseline medication was assessed 1 time (anamnesis)
measure: Aldosterone Antagonists
timeFrame: 1-time: At baseline medication was assessed 1 time (anamnesis)
measure: Male Gender as Predictor for SDB in Chronic HF
timeFrame: 1-time: At baseline physical status was assessed 1 time (anamnesis and medical records)
measure: Atrial Fibrillation (AF) as a Predictor for SDB in Chronic HF
timeFrame: 1-time: At baseline physical status was assessed 1 time (anamnesis and medical records)
measure: Ischemic Etiology as Predictor for SDB in Chronic HF
timeFrame: 1-time: At baseline physical status was assessed 1 time (anamnesis and medical records)
measure: NYHA Class >= III as Predictor for SDB in Chronic HF
timeFrame: 1-time: At baseline physical status was assessed 1 time (anamnesis and medical records)
Other outcomes:
Locations:
city: Westmead
country: Australia
facility: Westmead Hospital
state: New South Wales
city: Auchenflower
country: Australia
facility: Rivercity Private Hospital
state: Queensland
city: Adelaide
country: Australia
facility: Royal Adelaide Hospital
state: South Australia
city: East Melbourne
country: Australia
facility: Melbourne Sleep Disorders Centre
state: Victoria
city: Melbourne
country: Australia
facility: Baker IDI Heart and Diabetes Institute
state: Victoria
city: Melbourne
country: Australia
facility: St Vincents and Mercy Private Hospital
state: Victoria
city: Nedlands
country: Australia
facility: Hollywood Private Hospital (CVS)
state: Western Australia
city: Ingelheim am Rhein
country: Germany
facility: Cardiopraxis Ingelheim
state: Rheinland-Pfalz
city: Aachen
country: Germany
facility: Praxis Dr. Frieske
city: Aachen
country: Germany
facility: Universitätsklinikum Aachen
city: Alzey
country: Germany
facility: DRK Krankenhaus
city: Arnsberg
country: Germany
facility: Gemeinschaftspraxis Weiß/ Dr. Heesing
city: Bad Berka
country: Germany
facility: Zentralklinikum Bad Berka
city: Bad Krozingen
country: Germany
facility: Herzzentrum Bad Krozingen
city: Bad Krozingen
country: Germany
facility: Klinik Lazariterhof
city: Bad Mergentheim
country: Germany
facility: Praxis Dr. Bauer
city: Bad Oeynhausen
country: Germany
facility: HDZ NRW
city: Bad Wurzach
country: Germany
facility: Kardiologische Praxis Dr. Stroh
city: Bautzen
country: Germany
facility: Oberlausitz-Kliniken gGmbH
city: Bergisch Gladbach
country: Germany
facility: Kardiopraxis Rheinberg
city: Berlin
country: Germany
facility: Charité Campus Mitte CCM
city: Berlin
country: Germany
facility: Charité Campus Mitte
city: Berlin
country: Germany
facility: Praxis Gemeinschaft Frille
city: Berlin
country: Germany
facility: POLIKUM Friedenau
city: Berlin
country: Germany
facility: Gemeinschaftspraxis Groß-Ziethener Chaussee
city: Berlin
country: Germany
facility: Unfallkrankenhaus Berlin
city: Berlin
country: Germany
facility: Jüdisches Krankenhaus Berlin
city: Berlin
country: Germany
facility: Charité Campus Virchow Klinikum
city: Berlin
country: Germany
facility: Charité Campus Virchow-Klinikum
city: Berlin
country: Germany
facility: Praxis Westend
city: Bernau
country: Germany
facility: Herzzentrum Brandenburg
city: Bielefeld
country: Germany
facility: Praxis für Lunge,Herz und Schlaf
city: Bochum
country: Germany
facility: Kardiologie Gemeinschaftspraxis Dr. Tenholt
city: Bochum
country: Germany
facility: Universitätsklinikum Bergmannsheil
city: Bochum
country: Germany
facility: Augusta Krankenanstalten Bochum
city: Bochum
country: Germany
facility: St.-Josephs-Hospital
city: Bochum
country: Germany
facility: Kardiologie Kemnade
city: Bochum
country: Germany
facility: Kardiologische Praxis Dr. Staubach
city: Bonn
country: Germany
facility: Praxis für Kardiologie Bonn
city: Bonn
country: Germany
facility: Universitätsklinikum Bonn
city: Bonn
country: Germany
facility: Kardiologische Praxis Marschner
city: Bottrop
country: Germany
facility: Gemeinschaftspraxis Kardiologie
city: Bottrop
country: Germany
facility: Gemeinschaftspraxis Dres. Tinnefeld
city: Brühl
country: Germany
facility: Kardiologie Bühl
city: Burg/Spreewald
country: Germany
facility: Mediclin Rehazentrum Spreewald
city: Castrop-Rauxel
country: Germany
facility: Gemeinschaftspraxis Kardiologie Dr. Becker
city: Castrop-Rauxel
country: Germany
facility: Kardiologische Praxis Dr. Isbruch
city: Chemnitz
country: Germany
facility: MVZ am Küchwald
city: Coburg
country: Germany
facility: Klinikum Coburg GmbH
city: Coswig
country: Germany
facility: Fachkrankenhaus Coswig
city: Cottbus
country: Germany
facility: Carl-Thiem-Klinikum gGmbH
city: Dortmund
country: Germany
facility: Praxis Dr. Hecker
city: Dortmund
country: Germany
facility: Kardiologie - Gemeinschaftspraxis Dortmund
city: Dortmund
country: Germany
facility: Kardiologie-Gemeinschaftspraxis Dortmund
city: Dortmund
country: Germany
facility: Kardiologische Praxis Dr. Golling
city: Dortmund
country: Germany
facility: Klinikum Dortmund gGmbH
city: Dortmund
country: Germany
facility: Clinical Trial Site Services
city: Dortmund
country: Germany
facility: Kardiologische Praxis Dr. Wetzel
city: Dortmund
country: Germany
facility: Kardiologische Praxis Dr. Lodde
city: Dortmund
country: Germany
facility: Kardiologische Praxis Dr. Dröse
city: Dresden
country: Germany
facility: Facharztzentrum Dresden-Neustadt GbR
city: Dresden
country: Germany
facility: Gemeinschaftpraxis Dres. Schmidt/Gronke
city: Dresden
country: Germany
facility: Praxis Dr. Hohensee
city: Dresden
country: Germany
facility: Herzzentrum Universität Dresden
city: Duesseldorf
country: Germany
facility: Khs Florence-Nightingale
city: Düsseldorf
country: Germany
facility: goMedus Gesundheitszentrum
city: Düsseldorf
country: Germany
facility: Kardiologische Praxis Dr. Horowitz
city: Düsseldorf
country: Germany
facility: Kardiologische Praxis Dr. Raff
city: Düsseldorf
country: Germany
facility: Florence-Nightingale Krankenhaus
city: Düsseldorf
country: Germany
facility: Kardiologie Oberkassel
city: Düsseldorf
country: Germany
facility: Gemeinschaftspraxis PD Dr. Lankisch
city: Emmendingen
country: Germany
facility: Fachärzte für Innere Medizin Dres Ritter, Richter, Mehrer, Kahl
city: Erfurt
country: Germany
facility: Helios Klinikum Erfurt-Kardiologie
city: Erfurt
country: Germany
facility: Helios Klinikum Erfurt-Schlafmedizin
city: Erlangen
country: Germany
facility: Universitätsklinikum Erlangen
city: Essen
country: Germany
facility: Westdeutsches Herzzentrum, Universitätsklinikum Essen
city: Essen
country: Germany
facility: Kardiologische Praxis Dr. Cord Müller
city: Essen
country: Germany
facility: Schwerpunktpraxis Kardiologie Drs. Ophoff/Fritzsch
city: Essen
country: Germany
facility: Kardiologische Praxis Prof. Winter
city: Essen
country: Germany
facility: Kardiologie Praxis Dr. Bonnekamp
city: Essen
country: Germany
facility: Praxis Dr. Tekiyeh
city: Essen
country: Germany
facility: Elisabeth-Krankenhaus Essen
city: Essen
country: Germany
facility: Ruhrlandklinik Essen
city: Essen
country: Germany
facility: Praxis Dr. Rau
city: Essen
country: Germany
facility: Kath. Kliniken Essen / Philippusstift
city: Flonheim
country: Germany
facility: Gemeinschaftspraxis Dres. Guckenbiehl
city: Forst
country: Germany
facility: Kardiologische Praxis Dr. Kruse
city: Frankfurt
country: Germany
facility: CardioVasculäres Centrum Frankfurt
city: Frechen
country: Germany
facility: Praxis Dr. Diedrichs
city: Freiburg im Breisgau
country: Germany
facility: Universitaetsklinikum Freiburg
city: Freiburg im Breisgau
country: Germany
facility: Universitätsklinikum Freiburg
city: Gladbeck
country: Germany
facility: Gemeinschaftspraxis Dres. Böhmeke/Schmidt
city: Günzburg
country: Germany
facility: Kardiologische Praxis Dr. Hug
city: Gütersloh
country: Germany
facility: Kardiologische Praxis Gütersloh
city: Hagen
country: Germany
facility: Gemeinschaftspraxis Dres Leischik/Littwitz
city: Hagen
country: Germany
facility: Kardiologische Praxis Dr. Arens
city: Hamburg
country: Germany
facility: Gemeinschaftspraxis Dres. Subin/Lutter
city: Hamburg
country: Germany
facility: Universitätsklinikum Hamburg-Eppendorf
city: Hamburg
country: Germany
facility: Asklepios Klinik Barmbek
city: Hamburg
country: Germany
facility: Internistenpraxis Alstertal Hamburg
city: Hamburg
country: Germany
facility: Kardiologische Praxis Dr. Schröder
city: Hannover
country: Germany
facility: Kardiologische Praxis Dr. Cierpka
city: Hannover
country: Germany
facility: Praxis Dr. Hötte
city: Hannover
country: Germany
facility: Siloah Krankenhaus
city: Hannover
country: Germany
facility: Kardiologische Praxis Dr. Hartung
city: Heidelberg
country: Germany
facility: Heidelberger Praxisklinik für Kardiologie
city: Heidelberg
country: Germany
facility: Praxis Dr. Durak
city: Heidelberg
country: Germany
facility: Universitätsklinikum Heidelberg
city: Heidelberg
country: Germany
facility: Thoraxklinik Heidelberg gGmbH
city: Herne
country: Germany
facility: Evangelisches Krankenhaus Herne
city: Herne
country: Germany
facility: EvK Herne
city: Herne
country: Germany
facility: Kardiologische Praxis Dr. Furche
city: Herne
country: Germany
facility: Gemeinschaftspraxis Dr. Bruch
city: Herne
country: Germany
facility: Kardiologische Praxis Dr. Schlichting
city: Herten
country: Germany
facility: St. Elisabeth-Hospital Herten gGmbH
city: Hoyerswerda
country: Germany
facility: Praxis für Innere Medizin/Kardiologie
city: Karlstadt
country: Germany
facility: Gemeinschaftspraxis Dres. Dobler/Turin
city: Kassel
country: Germany
facility: Ambulantes Herzzentrum Kassel
city: Kempen
country: Germany
facility: Kardiologische Praxis Dr. Siegfried Frickel
city: Kitzingen
country: Germany
facility: Klinik Kitzinger Land
city: Krefeld
country: Germany
facility: Praxis Dr. Krater
city: Krefeld
country: Germany
facility: Helios Klinikum Krefeld
city: Köln
country: Germany
facility: St.-Vinzenz Hospital
city: Köln
country: Germany
facility: Kardiologische Praxis Dr. Fritsch
city: Köln
country: Germany
facility: Malteser Krankenhaus St. Hildegardis
city: Köln
country: Germany
facility: Klinikum der Universität zu Köln- Herzzentrum
city: Köln
country: Germany
facility: Prof. Franzen Institut
city: Köln
country: Germany
facility: Universitätsklinikum Köln-Herzzentrum
city: Köln
country: Germany
facility: Praxis Dr. Anselm Bäumer
city: Köln
country: Germany
facility: Gemeinschaftspraxis Dres. Gysan/Heinzler/May
city: Königs Wusterhausen
country: Germany
facility: Klinikum Dahme-Spreewald GmbH
city: Leipzig
country: Germany
facility: Universitätsklinikum Leipzig-Herzzentrum
city: Leisnig
country: Germany
facility: Helios Krankenhaus Leisnig
city: Lengerich
country: Germany
facility: Gemeinschaftspraxis Dr. Hilgedieck/Sava
city: Lindlar
country: Germany
facility: Kardiologische Praxis Dr. Faber
city: Lingen
country: Germany
facility: Ärztezentrum Holthausen-Biene
city: Ludwigsburg
country: Germany
facility: Kardiologische Praxis Ludwigsburg
city: Lübeck
country: Germany
facility: Universitätsklinikum Schleswig-Holstein Campus Lübeck-Kardiologie
city: Mainz
country: Germany
facility: Klinikum der Johannes Gutenberg-Universität Mainz
city: Mannheim
country: Germany
facility: Gemeinschaftspraxis Dres. Heifer/Loster/Schernus
city: Mannheim
country: Germany
facility: Gemeinschaftspraxis für Herz & Gefäße
city: Mannheim
country: Germany
facility: Universitätsklinik Mannheim-Kardiologie
city: Mannheim
country: Germany
facility: Gemeinschaftspraxis Dres. Brandt / Jakobs
city: Marburg
country: Germany
facility: Universitätsklinikum Gießen/Marburg Standort Marburg-Kardiologie
city: Meissen
country: Germany
facility: Praxis Dr. Schnabel
city: Memmingen
country: Germany
facility: Gemeinschaftspraxis Dr. Jocham
city: Menden
country: Germany
facility: Praxis für Kardiologie Dr. med. Menz
city: Metzingen
country: Germany
facility: Herz-& Gefäßpraxis
city: Minden
country: Germany
facility: Praxis Kutenhausen
city: Moers
country: Germany
facility: Krankenhaus Bethanien
city: Mühldorf
country: Germany
facility: Kardiologische Praxis Dr. Schön
city: Mülheim an der Ruhr
country: Germany
facility: Evangelisches Krankenhaus Mülheim
city: München
country: Germany
facility: Kardiologie am Rotkreuzplatz
city: München
country: Germany
facility: Gemeinschaftspraxis Dres. Wauer / Windstetter
city: München
country: Germany
facility: Kardiologische Praxis Dr. Herholz
city: München
country: Germany
facility: Klinikum Augustinum München
city: München
country: Germany
facility: Praxis Dres. Böhme/Linke
city: Münster
country: Germany
facility: Kardiologische Praxis Dr. Muradi
city: Münster
country: Germany
facility: Universitätsklinikum Münster
city: Münster
country: Germany
facility: Praxis für Kardiologie Dr. med. Hewing
city: Neuss
country: Germany
facility: Städtisches Khs Lukas
city: Nienburg
country: Germany
facility: Kardiologische Praxis Nienburg
city: Nürnberg
country: Germany
facility: Klinikum Nürnberg Süd
city: Ochtrup
country: Germany
facility: Kardiologische Praxis Dr. Gumbrecht
city: Plauen
country: Germany
facility: Kardiologische Praxis Dr. Hassler
city: Radebeul
country: Germany
facility: Kardiologische Praxis Dr. Wiethölter
city: Ratingen
country: Germany
facility: Praxis für Kardiologie Ratingen
city: Ratingen
country: Germany
facility: Praxis Dr. Fröhlich
city: Ratzeburg
country: Germany
facility: DRK Krankenhaus Mölln-Ratzeburg
city: Ravensburg
country: Germany
facility: Ambulantes Cardiovaskuläres Centrum
city: Recklinghausen
country: Germany
facility: Gemeinschaftspraxis Dr. Weber/Dr. Feja
city: Regensburg
country: Germany
facility: Universitätsklinikum Regensburg
city: Reinbek
country: Germany
facility: Khs St. Adolf Stift
city: Reinbek
country: Germany
facility: Praxis Dr. Hein
city: Remscheid
country: Germany
facility: Kardiologische Praxis Dr. Kleinz
city: Rheine
country: Germany
facility: Praxis Dr. Nebel
city: Rheine
country: Germany
facility: Praxis Dr. Kestermann
city: Rinteln
country: Germany
facility: Kardiologische Praxis Dr. Figura
city: Schwerte
country: Germany
facility: Kardiologische Praxis Dr. Heinze
city: Schönefeld
country: Germany
facility: Praxis Dr. Ebeling
city: Soest
country: Germany
facility: Praxisgemeinschaft Cardio-Soest
city: Sonneberg
country: Germany
facility: Facharztzentrum Sonneberg
city: Stollberg
country: Germany
facility: Kreiskrankenhaus Stollberg GmbH
city: Stollberg
country: Germany
facility: Kardiologische Praxis Dr. Birkenhagen
city: Uelzen
country: Germany
facility: Klinikum Uelzen GmbH
city: Ulm
country: Germany
facility: Herzklinik Ulm Dr. Haerer und Partner
city: Ulm
country: Germany
facility: Zentrum für Innere Medizin Uni Ulm
city: Unna
country: Germany
facility: Katharinen Hospital Unna
city: Viersen
country: Germany
facility: Kardiologische Praxis Dr. Burkhard-Meier
city: Waldkraiburg
country: Germany
facility: Praxis Dr. Gerritsen
city: Wangen
country: Germany
facility: Fachkliniken Wangen
city: Weißenhorn
country: Germany
facility: Stiftungsklinik Weißenhorn
city: Wiesbaden
country: Germany
facility: Kardiologisch angiologische Gemeinschaftspraxis
city: Wiesbaden
country: Germany
facility: Kardiologische Gemeinschaftspraxis Dr. K. Vorbeck
city: Witten
country: Germany
facility: Kardiologische Praxis Dr. Vrettos
city: Worms
country: Germany
facility: Kardiologische Praxis Dr. Rudolf/ Dr. Bernhardt
city: Würzburg
country: Germany
facility: Comprehensive Heart Failure Center, Universitätsklinikum Würzburg
city: Würzburg
country: Germany
facility: Universitätsklinikum Würzburg
city: Zweibrücken
country: Germany
facility: Evangel. Khs Zweibrücken
Study officials:
affiliation: Klinikum der Universität zu Köln
name: Erland Erdmann, Prof
role: PRINCIPAL_INVESTIGATOR
affiliation: Ruhrlandklinik Essen
name: Helmut Teschler, Prof
role: PRINCIPAL_INVESTIGATOR
affiliation: ResMed
name: Holger Woehrle, MD
role: STUDY_DIRECTOR
References:
citation: Woehrle H, Oldenburg O, Arzt M, Graml A, Erdmann E, Teschler H, Wegscheider K; SCHLA-HF Investigators. Determining the prevalence and predictors of sleep disordered breathing in patients with chronic heart failure: rationale and design of the SCHLA-HF registry. BMC Cardiovasc Disord. 2014 Apr 9;14:46. doi: 10.1186/1471-2261-14-46.
citation: Arzt M, Woehrle H, Oldenburg O, Graml A, Suling A, Erdmann E, Teschler H, Wegscheider K; SchlaHF Investigators. Prevalence and Predictors of Sleep-Disordered Breathing in Patients With Stable Chronic Heart Failure: The SchlaHF Registry. JACC Heart Fail. 2016 Feb;4(2):116-125. doi: 10.1016/j.jchf.2015.09.014. Epub 2015 Dec 9.
citation: Arzt M, Oldenburg O, Graml A, Erdmann E, Teschler H, Wegscheider K, Suling A, Woehrle H; SchlaHF Investigators. Phenotyping of Sleep-Disordered Breathing in Patients With Chronic Heart Failure With Reduced Ejection Fraction-the SchlaHF Registry. J Am Heart Assoc. 2017 Nov 29;6(12):e005899. doi: 10.1161/JAHA.116.005899.