Clinical trial NCT04611360: Anodal Transcranial Direct Current Stimulation on Mobility and Balance in Post Stroke Patients.
Official title: Effects of Anodal Transcranial Direct Current Stimulation on Mobility and Balance in Post Stroke Patients.
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Stroke
Keywords: Balance
Stroke
Anodal Transcranial Direct Current Stimulation
Lead sponsor: Riphah International University
Sponsor class: OTHER
First posted: 2020-11-02
Enrollment: 40
Sex: ALL
Minimum age (years): 35
Maximum age (years): 75
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: To determine the effects of anodal transcranial direct current stimulation on mobility and balance in post stroke patients.

Detailed description: Stroke is characterised as sudden onset of neurological dysfunction of central anxious framework that contain cerebral infarction, intra cranial haemorrhage \& subarachnoid haemorrhage. Around the globe stroke is the chief cause of incapacity and passing.

The trans-cranial direct current stimulations (tDCS) could be a non-invasive,low cost and capable brain stimulator utilised within the treatment of brain disorders.Two modes of tDCS is utilised is stroke patients,anodal stimulation (increased in excitability) of the lesional half of the globe and cathodal stimulation (decreased in excitability) of the contralesional hemisphere. The transcranial direct current stimulation induced polarity-dependent changes in membrane excitability, with Anodal-tDCS causing depolarisation and cathodal-tDCS causing hyper polarization of membrane potential in neurons of the stimulated area.

The role of Trans-cranial Direct Current Stimulation as a catalyst of recovery in stroke population and found that it's a safe,portable,non invasive brain stimulation technique. T-DCS is able to modulate the excitability of specified brain areas by varying the neuronal membrane potentials that based on the polarity of the current transmitted through the scalp via sponge electrodes. Trans-cranial direct current stimulation is clinically potential for use in stroke recovery because of its ease of use, non invasive-ness and safety.

Eligibility criteria: Inclusion Criteria:

* Patients presenting with both ischemic and hemorrhagic stroke
* Subacute and chronic stroke patients(onset of stroke from 3 months to 1 year)
* Ambulatory stroke survivors were included who met the criteria of Modified Rankin Scale between 1 and 3

Exclusion Criteria:

* Patients with Modified Rankin Scale of 0 and 4-6.
* Brain tumors
* Cognitive impaired
* Known case of seizures
* Metal implant, head injury etc and other disorders which contraindicate the application of anodal transcranial direct current stimulations.

Primary outcomes:
measure: Modified Rankin Scale
timeFrame: 6 week
measure: Dynamic Gait Index
timeFrame: 6 week
measure: 10 Meter Walk Test
timeFrame: 6 week
measure: Fugl Meyer function test:
timeFrame: 6 week
Secondary outcomes:
Other outcomes:
Locations:
city: Rawalpindi
country: Pakistan
facility: Pakistan Railway General Hospital
state: Punjab
Study officials:
affiliation: Riphah International University
name: Mirza Obaid Baig, MSPT
role: PRINCIPAL_INVESTIGATOR
References:
citation: Rossi C, Sallustio F, Di Legge S, Stanzione P, Koch G. Transcranial direct current stimulation of the affected hemisphere does not accelerate recovery of acute stroke patients. Eur J Neurol. 2013 Jan;20(1):202-4. doi: 10.1111/j.1468-1331.2012.03703.x. Epub 2012 Mar 26.
citation: Iosa M, Morone G, Fusco A, Bragoni M, Coiro P, Multari M, Venturiero V, De Angelis D, Pratesi L, Paolucci S. Seven capital devices for the future of stroke rehabilitation. Stroke Res Treat. 2012;2012:187965. doi: 10.1155/2012/187965. Epub 2012 Dec 13.
citation: Fusco A, Iosa M, Venturiero V, De Angelis D, Morone G, Maglione L, Bragoni M, Coiro P, Pratesi L, Paolucci S. After vs. priming effects of anodal transcranial direct current stimulation on upper extremity motor recovery in patients with subacute stroke. Restor Neurol Neurosci. 2014;32(2):301-12. doi: 10.3233/RNN-130349.