Clinical trial NCT02917070: Parental Consanguinity and Family History of Kidney Disease in Turkish Kidney Disease Population
Official title: The Importance of Parental Consanguinity and Family History of Kidney Disease in Turkish Adult Chronic Kidney Disease Population
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Hereditary Diseases
Keywords: Consanguinity-associated kidney diseases
Turkey population
Lead sponsor: Istanbul University
Sponsor class: OTHER
First posted: 2016-09-28
Enrollment: 2576
Sex: ALL
Minimum age (years): 18
Maximum age (years): 70
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: CASE_CONTROL
Time perspective: CROSS_SECTIONAL
Sampling method: NON_PROBABILITY_SAMPLE
Study population: All patients between 18 and 70 years of age who were on follow up in outpatient clinic and dialysis unit at the Istanbul Medical Faculty from October 2009 to October 2015 were included in the study

Brief summary: Inbreeding and consanguineous marriages are known to increase the risk of autosomal recessive disorders. The aim of this study was to examine the association between consanguinity and kidney diseases in the adult Turkish population.

Detailed description: This was a national, cross-sectional study recruiting patients from nephrology out-patient clinics and dialysis units. All patients between 18 and 70 years of age who were on follow up in outpatient clinic and dialysis unit at the Istanbul Medical Faculty from October 2009 to October 2015 were included in the study. All patients and healthy controls enrolled in this study gave informed consent to participate in the survey. They were all asked to answer a questionnaire including socio-demographic data, history of familial kidney disease and consanguineous marriage. Additional information was obtained from their private physicians and medical files. To ensure reliability of administration of the questionnaire, all interviewers underwent training using a standardized protocol.

Eligibility criteria: Inclusion Criteria:

* follow up in outpatient clinic and dialysis unit at the Istanbul Medical Faculty
* between 18-70 years old
* provide informed consent

Exclusion Criteria:

* follow-up shorter than 6 months
* patients whose data were not available
* patients who were unwilling or unable to provide informed consent

Primary outcomes:
measure: Effect of parental consanguinity on chronic kidney disease confirmed by a questionnaire did they have consanguinity marriage or not.
timeFrame: 6 months after enrollment
Secondary outcomes:
measure: Effect of family history of kidney disease on the development of chronic kidney confirmed by a questionnaire did they have any parents with chronic kidney diseases or not.
timeFrame: 6 months after enrollment
Other outcomes:
Locations:
city: Istanbul
country: Turkey
facility: Istanbul University, Istanbul Faculty of Medicine
Study officials:
affiliation: Istanbul University, Istanbul Faculty of Medicine, Department of Internal Medicine, Division of Nephrology
name: Yasar Caliskan, Dr.
role: PRINCIPAL_INVESTIGATOR
References:
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citation: O'Dea DF, Murphy SW, Hefferton D, Parfrey PS. Higher risk for renal failure in first-degree relatives of white patients with end-stage renal disease: a population-based study. Am J Kidney Dis. 1998 Nov;32(5):794-801. doi: 10.1016/s0272-6386(98)70135-0.