Clinical trial NCT04803617: Investigation of Pectoralis Muscle Strength in Elderly With Interstitial Lung Disease
Official title: The Effect of Pectoralis Muscle Strength on Pulmonary Function in Elderly With Interstitial Lung Disease
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Interstitial Lung Disease
Idiopathic Pulmonary Fibrosis
Sarcoidosis, Pulmonary
Geriatric
Keywords: pectoralis muscle strength
lung function test
respiratory muscle strength
horizontal adduction
Lead sponsor: Giresun University
Sponsor class: OTHER
First posted: 2021-03-17
Enrollment: 68
Sex: ALL
Minimum age (years): 65
Maximum age (years): 85
Standard ages: OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: CASE_CONTROL
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: The patient's group was selected from among the patients who applied to Süreyyapaşa Chest Diseases and Thoracic Surgery Training and Research Hospital.

The control group was selected among volunteers invited from the local community.

Brief summary: Interstitial lung disease (ILD) is a restrictive lung disease characterized by impaired lung function, exercise limitation and skeletal muscle dysfunction. There is limited data on skeletal muscle function in ILD, most of which are focused on the lower limb muscles. The aim of this study were to evaluated the change of pectoralis muscle strength and relationship of pulmonary function with pectoralis muscle strength.

Detailed description: This study consisted of intervention and control groups. Thirty one patients with ILD were included in the patient's group and 37 healthy volunteers in the control group. All participants were selected from the geriatric population. Demographic and cardiopulmonary physiotherapy assessment of all participants were performed. Lung function test, maximal inspiratory and expiratory pressure and pectoralis muscle strength were measured in participants of both groups. All measurements were performed once.

Eligibility criteria: Inclusion Criteria:

* Diagnosed with ILD by a multidisciplinary team according to the 2011 ATS/ERS guidelines for ILD
* Aged 65-85

Exclusion Criteria:

* Uncontrolled/active cardiovascular, metabolic, systemic or cancerous disease
* Significant orthopedic, neurologic or musculoskeletal comorbidity that limited functional independence
* No being able to cooperate
* Refuse to participate in the current study

Primary outcomes:
measure: Pectoralis muscle strength test
timeFrame: 15 minute
Secondary outcomes:
measure: FEV1
timeFrame: 5 minute
measure: FVC
timeFrame: 5 minute
measure: FEV1/FVC
timeFrame: 5 minute
measure: Respiratory muscle strength test
timeFrame: 15 minute
measure: Dyspnea assessment
timeFrame: 3 minute
Other outcomes:
Locations:
city: Giresun
country: Turkey
facility: Giresun University
Study officials:
affiliation: Giresun University
name: Habibe DURDU, MSc
role: PRINCIPAL_INVESTIGATOR
References:
citation: Raghu G, Collard HR, Egan JJ, Martinez FJ, Behr J, Brown KK, Colby TV, Cordier JF, Flaherty KR, Lasky JA, Lynch DA, Ryu JH, Swigris JJ, Wells AU, Ancochea J, Bouros D, Carvalho C, Costabel U, Ebina M, Hansell DM, Johkoh T, Kim DS, King TE Jr, Kondoh Y, Myers J, Muller NL, Nicholson AG, Richeldi L, Selman M, Dudden RF, Griss BS, Protzko SL, Schunemann HJ; ATS/ERS/JRS/ALAT Committee on Idiopathic Pulmonary Fibrosis. An official ATS/ERS/JRS/ALAT statement: idiopathic pulmonary fibrosis: evidence-based guidelines for diagnosis and management. Am J Respir Crit Care Med. 2011 Mar 15;183(6):788-824. doi: 10.1164/rccm.2009-040GL.
citation: Hirano M, Katoh M, Kawaguchi S, Uemura T. Intrarater reliabilities of shoulder joint horizontal adductor muscle strength measurements using a handheld dynamometer for geriatric and stroke patients. J Phys Ther Sci. 2016 Jan;28(1):51-5. doi: 10.1589/jpts.28.51. Epub 2016 Jan 30.
citation: Panagiotou M, Polychronopoulos V, Strange C. Respiratory and lower limb muscle function in interstitial lung disease. Chron Respir Dis. 2016 May;13(2):162-72. doi: 10.1177/1479972315626014. Epub 2016 Jan 14.
citation: Hanada M, Sakamoto N, Ishimatsu Y, Kakugawa T, Obase Y, Kozu R, Senjyu H, Izumikawa K, Mukae H, Kohno S. Effect of long-term treatment with corticosteroids on skeletal muscle strength, functional exercise capacity and health status in patients with interstitial lung disease. Respirology. 2016 Aug;21(6):1088-93. doi: 10.1111/resp.12807. Epub 2016 May 13.
citation: Durdu H, Yurdalan SU, Ozmen I. Clinical significance of pectoralis muscle strength in elderly patients with idiopathic pulmonary fibrosis. Sarcoidosis Vasc Diffuse Lung Dis. 2022;39(1):e2022009. doi: 10.36141/svdld.v39i1.12094. Epub 2022 Mar 31.