louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT06717958: Prospective Evaluation of Ivosidenib Maintenance Following Allogeneic Stem Cell Transplantation in Patients With Acute Myeloid Leukemia or High-risk Myelodysplastic Neoplasia With IDH1 (Isocitrate Dehydrogenase 1) Mutation
Official title: A Prospective, Single-arm, Open-label, Multicenter Phase II Trial Evaluating the Efficacy and Safety of Ivosidenib Maintenance Therapy After Allogeneic Stem Cell Transplantation (alloSCT) in Patients With Acute Myeloid Leukemia (AML) and Myelodysplastic Neoplasia (MD) Carrying an IDH1 Mutation
Study type: INTERVENTIONAL
Overall status: NOT_YET_RECRUITING
Phase: PHASE2
Conditions: AML
MDS
Lead sponsor: Technische Universität Dresden
Sponsor class: OTHER
First posted: 2024-12-05
Enrollment: 76
Sex: ALL
Minimum age (years): 18
Maximum age (years): 75
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: TREATMENT

Brief summary: maintenance of AML or MDS patients with known IDH1 mutation after allogeneic stem cell transplantation within past 100 days

Detailed description: Determination of the efficacy of Ivosidenib to improve event-free survival when given as maintenance therapy following alloSCT.

Eligibility criteria: Inclusion criterion:

* AML or MDS with IDH1 mutation

Exclusion criteria:

* active GvHD (graft vs host disease) grade III-IV according to Harris criteria requiring steroids \>1mg/ kg prednisolone equivalent

Primary outcomes:
measure: event-free survival
timeFrame: 24 months
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
References:
Clinical trial NCT01575158: Citalopram vs Clomipramine vs Placebo in Recurrent Depression
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Depression
Lead sponsor: University of Aarhus
Sponsor class: OTHER
Collaborators: name: Danish University Antidepressant Group
First posted: 2012-04-11
Enrollment: 59
Sex: ALL
Minimum age (years): 18
Maximum age (years): 70
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: citalopram and clomipramine are better than placebo in preventing new episodes of depression in patients with recurrent depression


Eligibility criteria: Inclusion Criteria:

* Patients with recurrent depression
* Sustained response achieved (3 consecutive monthly ratings at the HDS below 13)after a treatment requiring index episode

Exclusion Criteria:

* Contraindications to study medications
* Pregnancy
* Substance abuse

Primary outcomes:
measure: 2 Hamilton Depression Rating Scale scores of at least 16 with one weeks interval or initiation of another antidepressant treatment
timeFrame: 2 years of follow-up
Secondary outcomes:
measure: Study termination due to adverse event or non-compliance
timeFrame: 2 years of follow-up
Other outcomes:
Locations:
Study officials:
References:
Clinical trial NCT04640558: Gluteus Medius Latent Trigger Point and Muscle Strength in Healthy Subjects
Official title: The Relationship Between Gluteus Medius Latent Trigger Point and Muscle Strength in Healthy Subjects
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Myofascial Pain Syndrome
Muscle Weakness
Keywords: Trigger point
Gluteus medius muscle
Lead sponsor: Kars State Hospital
Sponsor class: OTHER
First posted: 2020-11-23
Enrollment: 48
Sex: MALE
Minimum age (years): 18
Maximum age (years): 40
Standard ages: ADULT
Observational model: OTHER
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: 24 participants who are clinically diagnosed with unilateral latent MTrP in the dominant side gluteus medius muscle and 24 participants who don't have latent MTrP.

Brief summary: This study aimed to investigate the relationship between latent MTrPs and gluteus medius muscle strength in a group of healthy adults.

Detailed description: Latent myofascial trigger points (MTrPs) do not cause spontaneous pain; however, they may lead to a limited range of motion and muscle weakness. We hypothesized that latent MTrPs might decrease gluteus medius muscle strength in healthy individuals. Forty-eight healthy men will be included in the study. Trigger point examination for the gluteus medius will be performed bilaterally. Subjects with one or more trigger points on the dominant side and those without any trigger points will be assigned to two groups. Muscle strength for gluteus medius will be assessed with a manual muscle tester using the "break test" technique on both sides. The subjects and the examiners will be blinded. For statistical analysis, the independent sample t-test was used to compare the intergroup differences.

Eligibility criteria: Inclusion Criteria:

* Patient age: 18-40 years.
* Absence of musculoskeletal complaints related to the lumbar, sacroiliac, and hip area.
* Absence of bilateral latent MTrP in the gluteus medius muscle.
* Latent trigger point in the gluteus medius muscle on the dominant side with palpation.

Exclusion Criteria:

* A history of medical treatment, physical therapy, injection therapy, or surgical treatment related to the lumbar, sacroiliac, and hip area.
* History of trauma, or malignancy or being pregnant, or if the patient is in the lactation period.
* Bilateral latent MTrP in the gluteus medius muscle.
* Presence of latent MTrP on the non-dominant side.

Primary outcomes:
measure: Gluteus medius muscle strength
timeFrame: One month
Secondary outcomes:
Other outcomes:
Locations:
city: İstanbul
country: Turkey
facility: Biruni University Faculty of Medicine
Study officials:
References:
Clinical trial NCT01559558: Changes of Pad Weight Results and Urethral Pressure Profiles After Reduction of Cystocele by Vaginal Gauze Packing
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Cystocele
Lead sponsor: National Taiwan University Hospital
Sponsor class: OTHER
First posted: 2012-03-21
Enrollment: 140
Sex: FEMALE
Minimum age (years): 20
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: CASE_ONLY
Time perspective: RETROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Patients with \>/= stage II cystocle

Brief summary: The purpose of this study is to retrospectively review the impact of vaginal packing on the urodynamic studies, especially for urethral pressure profiles.


Eligibility criteria: Inclusion Criteria:

* patients with \>= stage II cystocele and underwent urodynamic studies

Exclusion Criteria:

* patients less than 20 patients

Primary outcomes:
measure: Changes of pad weight and values of urethral pressure profiles after vaginal gauze packing.
timeFrame: 1 day
Secondary outcomes:
measure: The rate of anti-incontinence surgery using the criteria of pad weight > 8 gm after vaginal gauze packing as the indication of concomitant anti-incontinence surgery during cystocele repair
timeFrame: 5 years
Other outcomes:
Locations:
city: Taipei
country: Taiwan
facility: National Taiwan University Hospital
Study officials:
References:
Clinical trial NCT00204958: Glutamine Popsicles in Bone Marrow Transplant (BMT)/Hematopoietic Stem Cell Transplant (HSCT) Patients
Official title: Evaluation of Glutamine Popsicles in Adult/Pediatric Bone Marrow Transplant (BMT)/Hematopoietic Stem Cell Transplant (HSCT) Patients
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE4
Conditions: Bone Marrow Transplantation
Hematopoietic Stem Cell Transplantion
Keywords: bone marrow transplant (BMT)
hematopoietic stem cell transplant (HSCT)
Lead sponsor: University of Wisconsin, Madison
Sponsor class: OTHER
First posted: 2005-09-20
Enrollment: 50
Sex: ALL
Minimum age (years): 4
Maximum age (years): 75
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: FACTORIAL
Primary purpose: PREVENTION

Brief summary: Nutrition is an important part of the recovery process after having a head injury so that subjects can gain strength and fight off infection. Liquid nutrition formulas are often given to patients through a tube that has been placed into the intestines for feeding when they are unable to eat on their own. Some reports suggest that nutrition with extra amounts of the amino acid called glutamine may decrease infections and hospital stay in severely injured patients. The purpose of this study is to evaluate if giving extra amounts of an amino acid called glutamine with liquid nutrition formulas will decrease the risk of infection and length of stay in the intensive care unit after having a head injury.


Eligibility criteria: Inclusion Criteria:

* Males
* Nonpregnant females
* Receiving chemotherapy for BMT/HSCT

Exclusion Criteria:

* Documented hepatic dysfunction
* History of cirrhosis
* History of acute renal failure (creatinine clearance \< 25 mL/min)
* Gastrointestinal malabsorptive disorder

Primary outcomes:
measure: grade of mucositis
Secondary outcomes:
measure: need for intravenous versus oral nutritional supplementation
Other outcomes:
Locations:
city: Madison
country: United States
facility: University of Wisconsin
state: Wisconsin
Study officials:
affiliation: University of Wisconsin, Madison
name: Gordon S Sacks, PharmD., FCCP, BCNSP
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT00176358: Percutaneous Coronary Angioplasty Compared With Exercise Training in Symptomatic Coronary Artery Disease
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: PHASE2
PHASE3
Conditions: CAD
Stable Angina Pectoris
Lead sponsor: University of Leipzig
Sponsor class: OTHER
First posted: 2005-09-15
Enrollment: 400
Sex: ALL
Minimum age (years): 18
Maximum age (years): 75
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The purpose of this study is to compare coronary angioplasty with stent implantation with an exercise rehabilitation program in patients with stable coronary artery disease (CAD).


Eligibility criteria: Inclusion Criteria:

* Angiographically documented CAD, with at least one coronary artery stenosis of more than 50% in a native segment never subjected to intervention, which is recommended for treatment with percutaneous transluminal coronary angioplasty (PTCA).
* Stable coronary artery disease
* Eligible patients could be asymptomatic or have class I to III angina (Canadian Cardiovascular Society \[CCS\]) with documented myocardial ischemia
* Angina pectoris threshold \> 50 Watt (cycle ergometry)
* Permanent residence should be within 25 km of training facility.

Exclusion Criteria:

* \< 18 or \> 70 years of age
* Patient currently participating in an exercise training program
* Unstable angina pectoris or myocardial infarction during the last 2 weeks
* Symptoms of CCS class IV
* Exercise limitations due to clinical conditions not related to CAD
* Left ventricular ejection fraction (LVEF) of \< 40%
* Ventricular arrhythmia (Lown Ivb)
* Hemodynamically significant valvular heart disease
* Previous cardiac surgery
* PTCA performed during the last 12 months
* Any major non-cardiac condition that would adversely affect survival during the duration of the study
* Reduced compliance

Primary outcomes:
Secondary outcomes:
Other outcomes:
Locations:
city: Leipzig
country: Germany
facility: University of Leipzig - Heart Center
Study officials:
affiliation: Heart Center Leipzig - University Hospital
name: Rainer Hambrecht, Prof.
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT05072158: Pelvic Floor Disorders Among Sexual Minoritized Women
Official title: Pelvic Floor Disorders Among Sexual Minoritized Women
Study type: OBSERVATIONAL
Overall status: TERMINATED
Conditions: Sexual Function Disturbances
Pelvic Organ Prolapse
Urinary Incontinence
Fecal Incontinence
Lead sponsor: University of New Mexico
Sponsor class: OTHER
Collaborators: name: Albany Medical College
name: University of Texas at Austin
First posted: 2021-10-08
Enrollment: 18
Sex: FEMALE
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: New patients over the age of 18 who present to urogynecology office or contact the research team with interest in participating in the study who self-identify as women who have sex with women. This may include but is not limited to: lesbian and bisexual women.

Brief summary: The investigators aim to perform cognitive interviews to assess how pelvic floor disorders impact sexual functioning in women who have sex with women (WSW). As a secondary objective there will be cognitive interviews to assess perceptions of sexual function questionnaires such as Female Sexual Function Index (FSFI) and Pelvic Organ Prolapse/Urinary Incontinence Sexual Questionnaire-IUGA Revised (PISQ-IR) in WSW.

Detailed description: There is a paucity of data regarding care of women who have sex with women (WSW). While some cohort studies are being performed in general gynecology, no studies document the reasons as to why WSW seek urogynecological care, or how pelvic floor disorders (PFDs) affect sexual function in this population. Another detrimental gap in current knowledge and a barrier to care for WSW is the lack of understanding of what would drive WSW to seek care, if there are special considerations for care, or if the commonly used condition specific questionnaires adequately reflect their concerns. The Investigators aim to perform qualitative interviews to understand how PFDs affect sexual function, and if commonly utilized sexual function questionnaires are inclusive to WSW.

Eligibility criteria: Inclusion Criteria:

* WSW who have a PFD (pelvic organ prolapse, urinary incontinence, fecal incontinence)
* Age \>18
* Able to provide consent
* Able to read/write in English

Exclusion Criteria:

* WSW who have not been sexually active in the past 6 months
* Incarcerated patients
* Pregnant or lactating patients
* Unable to consent with study procedures or guided discussions
* Unable to speak English
* No sexual activity in the past 6 months

Primary outcomes:
measure: Qualitative impact of pelvic floor disorders on sexual function
timeFrame: 6 months
Secondary outcomes:
measure: Qualitative inclusivity of sexual function questionnaires
timeFrame: 6 months
Other outcomes:
Locations:
city: Albuquerque
country: United States
facility: University of New Mexico
state: New Mexico
Study officials:
affiliation: University of New Mexico
name: Sierra Jansen, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT05837858: The Human Metabolic Profile and Gut Microbiota Under Various Dietary Quality
Official title: Study on Biomarkers of Whole Grain Dietary Intake in Chinese Population
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Biomarkers
Keywords: Food biomarker
Whole grain
Chinese population
Lead sponsor: Peking University
Sponsor class: OTHER
First posted: 2023-05-01
Enrollment: 24
Sex: ALL
Minimum age (years): 18
Maximum age (years): 40
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: CROSSOVER
Intervention model description: Randomized Crossover Assignment
Primary purpose: BASIC_SCIENCE

Brief summary: The goal of this food intervention study is to screen/validate the whole grain food intake biomarker in health Chinese's population.

Detailed description: Although increased consumption of whole grains (WGs) is associated with improved health outcomes, the dietary intake assessment and health mechanisms for WGs or WG-containing food remain unresolved. In addition, information regarding its consumption and health effects in Chinese people is scarce. Biomarkers of WGs intake would allow a more accurate assessment of its consumption in nutrition studies. The investigators want to perform a crossover study where participants were subjected to a WG-wheat flour or a refine wheat-flour Chinese diet. Using a metabolomics approach, the investigators aimed to identify the WG-specific metabolites present in plasma/urine after consumption WG or WG foods, including new candidate biomarkers of WG intake.

Eligibility criteria: Inclusion Criteria:

* Healthy men and women
* age 18-40 years
* BMI 18.5-23.9 kg/m2.

Exclusion Criteria:

* pregnancy or breastfeeding
* vegetarian;
* smokers;
* acute and chronic diseases;
* allergic to wheat;
* frequent nutrients supplement use;
* medication use of antibiotics within 1-month;
* more than 3 kg weight change within 3-month;
* unwillingness to follow dietary restrictions;

Primary outcomes:
measure: Changes in metabolite profiles present in blood plasma and urine before the dietary intervention and in kinetics over 24 hours.
timeFrame: Baseline and 0-24 hours after intervention food intake
Secondary outcomes:
measure: The influence of gut flora on whole grain markers
timeFrame: after the administration of the test meal
Other outcomes:
Locations:
city: Beijing
country: China
facility: Department of Nutrition and Food Hygiene, School of Public Health, Peking University
Study officials:
affiliation: Peking University
name: Yunjia yang
role: PRINCIPAL_INVESTIGATOR
affiliation: Peking University
name: Yalin Zhou
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT03733158: Flexible Tip Bougie Catheter Intubation
Official title: Comparison of the New Flexible Tip Bougie Catheter and Standard Bougie Stylet for Tracheal Intubation by Anesthesiologists in Different Difficult Airway Scenarios: a Randomized Crossover Trial
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Emergency Medicine
Endotracheal Intubation
Cardiopulmonary Arrest
Keywords: endotracheal intubation
emergency medicine
cardiopulmonary resuscitation
physician
Lead sponsor: Lazarski University
Sponsor class: OTHER
First posted: 2018-11-07
Enrollment: 32
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: CROSSOVER
Primary purpose: TREATMENT

Brief summary: We, therefore conducted a randomized cross over study to evaluate the usefulness of this new device use by experienced anesthesiologists in several airway manikin scenarios. We hypothesized that in the hands of experienced anesthesiologists the new Flexible Tip Bougie catheter would perform comparably to the standard bougie catheter) in the normal airway scenario. In the difficult airway (both tongue edema, manual in-line stabilization, or cervical collar stabilization), we hypothesized that the new Flexible Tip Bougie catheter would prove superior to the standard Bougie stylet.


Eligibility criteria: Inclusion Criteria:

* physicians
* give voluntary consent to participate in the study
* none experience in videolaryngoscopy
* less than 1 year experience in medicine

Exclusion Criteria:

* not meet the above criteria
* wrist or low back diseases

Primary outcomes:
measure: time to intubation
timeFrame: 1 day
Secondary outcomes:
measure: success of intubation
timeFrame: 1 day
measure: Number of optimalization maneuvers
timeFrame: 1 day
measure: Ease of use
timeFrame: 1 day
measure: Dental compression
timeFrame: 1 day
Other outcomes:
Locations:
city: Warsaw
country: Poland
facility: Lazarski University
state: Masovia
Study officials:
affiliation: Lazarski University
name: Lukasz Szarpak, Phd
role: PRINCIPAL_INVESTIGATOR
References:
citation: Ruetzler K, Smereka J, Abelairas-Gomez C, Frass M, Dabrowski M, Bialka S, Misiolek H, Plusa T, Robak O, Aniolek O, Ladny JR, Gorczyca D, Ahuja S, Szarpak L. Comparison of the new flexible tip bougie catheter and standard bougie stylet for tracheal intubation by anesthesiologists in different difficult airway scenarios: a randomized crossover trial. BMC Anesthesiol. 2020 Apr 20;20(1):90. doi: 10.1186/s12871-020-01009-7.
Clinical trial NCT02651558: Optical System to Continuously Measure Arterial Blood Pressure
Official title: Comparison of an Optical System to Continuously Measure Arterial Blood Pressure Against a Gold-standard Arterial Catheter
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Blood Pressure
Lead sponsor: CSEM Centre Suisse d'Electronique et de Microtechnique SA - Recherche et Developpement
Sponsor class: INDUSTRY
Collaborators: name: Centre Hospitalier Universitaire Vaudois
First posted: 2016-01-11
Enrollment: 70
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: NON_RANDOMIZED
Intervention model: SINGLE_GROUP
Primary purpose: DIAGNOSTIC

Brief summary: Comparison of an optical method to continuously measure blood pressure against an invasive arterial catheter.

Detailed description: The measurement of blood pressure during anesthesia is commonly performed by the inflation of a brachial cuff providing only intermittent blood pressure measurements. In some case, it is required to add a continuous invasive monitoring of blood pressure, via the insertion of an arterial catheter. Unfortunately, the related morbidity is not negligible. To limit the consequences of such a gesture, some developments have been done in the past to allow for continuous non-invasive measurements of blood pressure during anesthesia. Unfortunately, most of these devices are subject to important limitations and constraints of use.

A new system has been designed by CSEM consisting of an optical system fixed on patient's skin, absolutely non-invasive and easy to use. In order to study the reliability of this device, the investigators plan to compare its blood pressure estimates against gold-standard arterial catheter measurements during induction of general anesthesia on:

* 40 patients wearing the optical system at the chest.
* and 40 patients wearing the optical system at the fingertip

Eligibility criteria: Inclusion Criteria:

* patient requiring the placement of an arterial catheter for general anesthesia
* minimum of 18 years
* written consent

Exclusion Criteria:

* minor patient or incapable of discernment
* patient with AIMD
* thoracic surgery

Primary outcomes:
measure: Error (in mmHg) between paired determinations of arterial blood pressure from an optical device against reference measurements from an arterial catheter
timeFrame: 24 months
Secondary outcomes:
Other outcomes:
Locations:
city: Lausanne
country: Switzerland
facility: CHUV
Study officials:
affiliation: CHUV
name: Patrick Schoettker
role: PRINCIPAL_INVESTIGATOR
References:
citation: Ghamri Y, Proenca M, Hofmann G, Renevey P, Bonnier G, Braun F, Axis A, Lemay M, Schoettker P. Automated Pulse Oximeter Waveform Analysis to Track Changes in Blood Pressure During Anesthesia Induction: A Proof-of-Concept Study. Anesth Analg. 2020 May;130(5):1222-1233. doi: 10.1213/ANE.0000000000004678.