Clinical trial NCT00951639: Cassia Cinnamon for Glucose Uptake in Young Women
Official title: Cassia Cinnamon and Acute Endurance Exercise for the Enhancement of Glucose Uptake in Healthy Young Women
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Insulin Resistance
Impaired Glucose Tolerance
Prediabetes
Keywords: Cassia
Cinnamon
Blood Glucose
Endurance exercise
Acute exercise
Overweight
Obesity
Women
Lead sponsor: Baylor University
Sponsor class: OTHER
First posted: 2009-08-04
Enrollment: 10
Sex: FEMALE
Minimum age (years): 18
Maximum age (years): 30
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: CROSSOVER
Primary purpose: SUPPORTIVE_CARE

Brief summary: The purpose of this study was to compare the acute effects of 5g of Cassia cinnamon, 50 minutes of endurance exercise performed at 70% of the heart rate reserve (correlated to VO2max), and 5g of cellulose placebo on blood glucose, serum insulin and insulin sensitivity following an oral glucose tolerance test 3 hours after administration of each intervention.


Eligibility criteria: Inclusion Criteria:

* Sedentary
* BMI: 27-45
* DXA body fat % greater than 30%
* 18-30 years of age
* Healthy
* From the Baylor University campus and surrounding community
* Regular sleep habits

Exclusion Criteria:

* Not regular users of any species of cinnamon
* Not diagnosed with any metabolic disorder or chronic medical condition
* Not taking prescription medications for 2 months before the study
* Not taking ergogenic aids for 2 months before the study
* Not taking oral contraceptives for 2 months before the study
* No IUD placed for 2 months before the study

Primary outcomes:
measure: Blood Glucose
timeFrame: Baseline, 0, 30, 60, 90 and 120 minutes following OGTT
Secondary outcomes:
measure: Serum Insulin
timeFrame: Baseline, 0, 30, 60, 90 and 120 minutes following OGTT
Other outcomes:
Locations:
city: Waco
country: United States
facility: Baylor University Department of Health, Human Performance, and Recreation
state: Texas
Study officials:
affiliation: Baylor University
name: Darryn S Willoughby, Ph.D.
role: STUDY_CHAIR
affiliation: Baylor University
name: Jean L Gutierrez, Ph.D.
role: PRINCIPAL_INVESTIGATOR
References:
citation: Hlebowicz J, Darwiche G, Bjorgell O, Almer LO. Effect of cinnamon on postprandial blood glucose, gastric emptying, and satiety in healthy subjects. Am J Clin Nutr. 2007 Jun;85(6):1552-6. doi: 10.1093/ajcn/85.6.1552.
citation: Hlebowicz J, Hlebowicz A, Lindstedt S, Bjorgell O, Hoglund P, Holst JJ, Darwiche G, Almer LO. Effects of 1 and 3 g cinnamon on gastric emptying, satiety, and postprandial blood glucose, insulin, glucose-dependent insulinotropic polypeptide, glucagon-like peptide 1, and ghrelin concentrations in healthy subjects. Am J Clin Nutr. 2009 Mar;89(3):815-21. doi: 10.3945/ajcn.2008.26807. Epub 2009 Jan 21.
citation: Solomon TP, Blannin AK. Changes in glucose tolerance and insulin sensitivity following 2 weeks of daily cinnamon ingestion in healthy humans. Eur J Appl Physiol. 2009 Apr;105(6):969-76. doi: 10.1007/s00421-009-0986-9. Epub 2009 Jan 22.
citation: Solomon TP, Blannin AK. Effects of short-term cinnamon ingestion on in vivo glucose tolerance. Diabetes Obes Metab. 2007 Nov;9(6):895-901. doi: 10.1111/j.1463-1326.2006.00694.x.