Clinical trial NCT03467958: An Extension Study of Oral Ozanimod for Moderately to Severely Active Crohn's Disease
Official title: A Phase 3, Multicenter, Open-Label Extension Study of Oral Ozanimod for Moderately to Severely Active Crohn's Disease
Study type: INTERVENTIONAL
Overall status: TERMINATED
Phase: PHASE3
Conditions: Crohn Disease
Keywords: Crohn's Disease
Crohn Disease
Oral
Ozanimod
Moderately active
Severely active
RPC01
RPC01-3204
Lead sponsor: Celgene
Sponsor class: INDUSTRY
First posted: 2018-03-16
Enrollment: 854
Sex: ALL
Minimum age (years): 18
Maximum age (years): 75
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: TREATMENT

Brief summary: This is an extension study to evaluate safety and efficacy of ozanimod in participants with moderately to severely active Crohn's Disease.


Eligibility criteria: For more information regarding Bristol-Myers Squibb Clinical Trial participation, please visit: www.BMSStudyConnect.com

Inclusion Criteria:

* Is not in clinical response or clinical remission after completing 12 weeks in the Induction Studies
* Experience relapse or who complete the Maintenance Study
* Complete a study of ozanimod for Crohn's Disease and meet the criteria for participation

Exclusion Criteria:

* Has any clinically relevant hepatic, neurological, pulmonary, ophthalmological, endocrine, psychiatric, or other major systemic disease making implementation of the protocol or interpretation of the study difficult or that would put the subject at risk by participating in the study
* Has suspected or diagnosed intra-abdominal or perianal abscess that has not been appropriately treated
* Is receiving treatment with any of the following drugs or interventions: CYP2C8 inducers; Monoamine oxidase inhibitors

Other protocol-defined inclusion/exclusion criteria apply

Primary outcomes:
measure: Proportion of participants with a CDAI score of < 150
timeFrame: Up to 264 Weeks
measure: Incidence of adverse events (AEs)
timeFrame: Up to 264 weeks
measure: Incidence of serious adverse events (SAEs)
timeFrame: Up to 264 weeks
measure: Incidence of adverse events leading to discontinuation
timeFrame: Up to 264 weeks
Secondary outcomes:
measure: Proportion of participants with average daily abdominal pain score ≤ 1 point, and average daily stool frequency ≤ 3 points with abdominal pain and stool frequency no worse than baseline
timeFrame: Up to 264 Weeks
measure: Proportion of participants with CDAI reduction from baseline of ≥ 100 points or CDAI score of < 150
timeFrame: Up to 264 Weeks
Other outcomes:
Locations:
city: Peoria
country: United States
facility: Holland Center for Family Health
state: Arizona
city: Scottsdale
country: United States
facility: Local Institution - 202
state: Arizona
city: North Little Rock
country: United States
facility: Local Institution - 026
state: Arkansas
city: Camarillo
country: United States
facility: Local Institution - 284
state: California
city: Chula Vista
country: United States
facility: Sharp Chula Vista Medical Center
state: California
city: Garden Grove
country: United States
facility: Local Institution - 039
state: California
city: La Jolla
country: United States
facility: Ucsd Medical Center
state: California
city: La Mesa
country: United States
facility: San Diego Clinical Trials
state: California
city: Lancaster
country: United States
facility: Local Institution - 010
state: California
city: Los Angeles
country: United States
facility: Local Institution - 061
state: California
city: Los Angeles
country: United States
facility: Southern California Research Institute Medical Group, Inc.
state: California
city: Los Angeles
country: United States
facility: Matrix Clinical Research Inc
state: California
city: Los Angeles
country: United States
facility: Local Institution - 110
state: California
city: Mission Hills
country: United States
facility: Facey Medical Foundation (Parent)
state: California
city: Mission Viejo
country: United States
facility: ABS Health, LLC
state: California
city: Oceanside
country: United States
facility: Alliance Clinical Research
state: California
city: Orange
country: United States
facility: Local Institution - 027
state: California
city: Palo Alto
country: United States
facility: Palo Alto Center-Palo Alto Medical Foundation Research Institute
state: California
city: Pasadena
country: United States
facility: Havana Research Institute LLC
state: California
city: Rialto
country: United States
facility: Local Institution - 006
state: California
city: Roseville
country: United States
facility: Sutter Medical Group
state: California
city: Sacramento
country: United States
facility: Local Institution - 280
state: California
city: San Diego
country: United States
facility: Local Institution - 003
state: California
city: San Francisco
country: United States
facility: Local Institution - 281
state: California
city: West Covina
country: United States
facility: New Hope Research Development
state: California
city: Colorado Springs
country: United States
facility: Local Institution - 065
state: Colorado
city: Lakewood
country: United States
facility: Local Institution - 297
state: Colorado
city: Bristol
country: United States
facility: Local Institution - 182
state: Connecticut
city: Bristol
country: United States
facility: Local Institution - 225
state: Connecticut
city: New Haven
country: United States
facility: Local Institution - 091
state: Connecticut
city: Clearwater
country: United States
facility: Local Institution - 062
state: Florida
city: Clearwater
country: United States
facility: Clinical Research of West Florida
state: Florida
city: Clermont
country: United States
facility: South Lake Pain Institute
state: Florida
city: Cutler Bay
country: United States
facility: American Research Institute Inc
state: Florida
city: Doral
country: United States
facility: Local Institution - 112
state: Florida
city: Edgewater
country: United States
facility: Riverside Clinical Research
state: Florida
city: Gainesville
country: United States
facility: Local Institution - 218
state: Florida
city: Hialeah
country: United States
facility: Local Institution - 203
state: Florida
city: Hialeah
country: United States
facility: Floridian Clinical Research LLC
state: Florida
city: Hialeah
country: United States
facility: Harmony Medical Research Institute
state: Florida
city: Hollywood
country: United States
facility: Local Institution - 179
state: Florida
city: Homestead
country: United States
facility: Vista Health Research
state: Florida
city: Kissimmee
country: United States
facility: SIH Research
state: Florida
city: Largo
country: United States
facility: Local Institution - 016
state: Florida
city: Lighthouse Point
country: United States
facility: Local Institution - 067
state: Florida
city: Maitland
country: United States
facility: Center For Advanced Gastroenterology
state: Florida
city: Miami Springs
country: United States
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state: Florida
city: Miami
country: United States
facility: LMG Research
state: Florida
city: Miami
country: United States
facility: Local Institution - 199
state: Florida
city: Miami
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facility: LCC Medical Research Institute, LLC
state: Florida
city: Miami
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facility: Local Institution - 169
state: Florida
city: Miami
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facility: Local Institution - 175
state: Florida
city: Miami
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facility: Vista Health Research
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country: United States
facility: Advanced Research for Health Improvement
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city: New Port Richey
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facility: Local Institution - 192
state: Florida
city: New Smyrna Beach
country: United States
facility: Local Institution - 214
state: Florida
city: Orlando
country: United States
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state: Florida
city: Orlando
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facility: Local Institution - 076
state: Florida
city: Palmetto Bay
country: United States
facility: Local Institution - 002
state: Florida
city: Pinellas Park
country: United States
facility: Theia Clinical Research, LLC
state: Florida
city: Port Orange
country: United States
facility: Local Institution - 098
state: Florida
city: Sunrise
country: United States
facility: Precision Clinical Research, LLC.
state: Florida
city: Tampa
country: United States
facility: Local Institution - 183
state: Florida
city: Tampa
country: United States
facility: Apex Clinical Research
state: Florida
city: Tampa
country: United States
facility: Local Institution - 226
state: Florida
city: Tampa
country: United States
facility: Local Institution - 107
state: Florida
city: Tampa
country: United States
facility: Local Institution - 149
state: Florida
city: Weeki Wachee
country: United States
facility: Local Institution - 114
state: Florida
city: Atlanta
country: United States
facility: Consultative Gastroenterology
state: Georgia
city: Atlanta
country: United States
facility: Local Institution - 037
state: Georgia
city: Atlanta
country: United States
facility: Local Institution - 220
state: Georgia
city: Atlanta
country: United States
facility: Local Institution - 222
state: Georgia
city: Atlanta
country: United States
facility: Local Institution - 019
state: Georgia
city: Atlanta
country: United States
facility: Local Institution - 063
state: Georgia
city: Columbus
country: United States
facility: Local Institution - 074
state: Georgia
city: Decatur
country: United States
facility: Local Institution - 143
state: Georgia
city: Macon
country: United States
facility: Local Institution - 028
state: Georgia
city: Idaho Falls
country: United States
facility: Local Institution - 115
state: Idaho
city: Chicago
country: United States
facility: Local Institution - 194
state: Illinois
city: Chicago
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facility: Local Institution - 036
state: Illinois
city: Chicago
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facility: Local Institution - 022
state: Illinois
city: Oak Lawn
country: United States
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state: Illinois
city: Urbana
country: United States
facility: Carle Foundation Hospital
state: Illinois
city: Evansville
country: United States
facility: Local Institution - 092
state: Indiana
city: Indianapolis
country: United States
facility: Local Institution - 033
state: Indiana
city: Clive
country: United States
facility: Iowa Digestive Disease Center
state: Iowa
city: Topeka
country: United States
facility: Local Institution - 070
state: Kansas
city: Lexington
country: United States
facility: Local Institution - 155
state: Kentucky
city: Baton Rouge
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state: Louisiana
city: Houma
country: United States
facility: CroNOLA LLC
state: Louisiana
city: Lake Charles
country: United States
facility: Centex Studies, Inc.
state: Louisiana
city: Lake Charles
country: United States
facility: Clinical Trials of SW Louisiana LLC
state: Louisiana
city: Marrero
country: United States
facility: Tandem Clinical Research, LLC
state: Louisiana
city: New Orleans
country: United States
facility: Nola Research Works
state: Louisiana
city: Baltimore
country: United States
facility: Local Institution - 278
state: Maryland
city: Catonsville
country: United States
facility: Local Institution - 129
state: Maryland
city: Glen Burnie
country: United States
facility: Local Institution - 282
state: Maryland
city: Chestnut Hill
country: United States
facility: Local Institution - 142
state: Massachusetts
city: North Worcester
country: United States
facility: Local Institution - 228
state: Massachusetts
city: Springfield
country: United States
facility: Local Institution - 286
state: Massachusetts
city: Worcester
country: United States
facility: Local Institution - 024
state: Massachusetts
city: Caro
country: United States
facility: Local Institution - 191
state: Michigan
city: Kalamazoo
country: United States
facility: Local Institution - 167
state: Michigan
city: Novi
country: United States
facility: Local Institution - 005
state: Michigan
city: Southfield
country: United States
facility: Local Institution - 108
state: Michigan
city: Wyoming
country: United States
facility: Local Institution - 301
state: Michigan
city: Ypsilanti
country: United States
facility: Local Institution - 300
state: Michigan
city: Minneapolis
country: United States
facility: Local Institution - 095
state: Minnesota
city: Rochester
country: United States
facility: Local Institution - 045
state: Minnesota
city: Jackson
country: United States
facility: Local Institution - 274
state: Mississippi
city: Kansas City
country: United States
facility: Local Institution - 198
state: Missouri
city: Saint Louis
country: United States
facility: Local Institution - 029
state: Missouri
city: Las Vegas
country: United States
facility: Internal Medicine Specialists
state: Nevada
city: Lebanon
country: United States
facility: Local Institution - 040
state: New Hampshire
city: Englewood
country: United States
facility: Local Institution - 215
state: New Jersey
city: Bronx
country: United States
facility: Advantage Clinical Trials
state: New York
city: Brooklyn
country: United States
facility: Local Institution - 144
state: New York
city: Great Neck
country: United States
facility: Local Institution - 009
state: New York
city: Hartsdale
country: United States
facility: Local Institution - 054
state: New York
city: New York
country: United States
facility: Weill Cornell Medical College
state: New York
city: New York
country: United States
facility: Concorde Medical Group
state: New York
city: New York
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facility: Local Institution - 105
state: New York
city: New York
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facility: TrialSpark
state: New York
city: New York
country: United States
facility: Local Institution - 043
state: New York
city: North Massapequa
country: United States
facility: Local Institution - 060
state: New York
city: Orchard Park
country: United States
facility: Circuit Clinical
state: New York
city: Asheville
country: United States
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state: North Carolina
city: Charlotte
country: United States
facility: Local Institution - 152
state: North Carolina
city: Charlotte
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state: North Carolina
city: Charlotte
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state: North Carolina
city: Greenville
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state: North Carolina
city: Raleigh
country: United States
facility: Local Institution - 302
state: North Carolina
city: Winston-Salem
country: United States
facility: Local Institution - 052
state: North Carolina
city: Beachwood
country: United States
facility: Great Lakes Medical Research, LLC
state: Ohio
city: Cincinnati
country: United States
facility: Local Institution - 291
state: Ohio
city: Cleveland
country: United States
facility: Local Institution - 018
state: Ohio
city: Dayton
country: United States
facility: Local Institution - 170
state: Ohio
city: Hilliard
country: United States
facility: Local Institution - 049
state: Ohio
city: Mentor
country: United States
facility: Great Lakes Gastroenterology
state: Ohio
city: Middleburg Heights
country: United States
facility: Local Institution - 141
state: Ohio
city: Warren
country: United States
facility: Great Lakes Medical Research, LLC
state: Ohio
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state: Oklahoma
city: Oklahoma City
country: United States
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state: Oklahoma
city: Oklahoma City
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state: Oklahoma
city: Oklahoma City
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state: Oklahoma
city: Tulsa
country: United States
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state: Oklahoma
city: Tulsa
country: United States
facility: Local Institution - 217
state: Oklahoma
city: Portland
country: United States
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state: Oregon
city: Hershey
country: United States
facility: Local Institution - 197
state: Pennsylvania
city: Philadelphia
country: United States
facility: University of Pennsylvania Cancer Center
state: Pennsylvania
city: State College
country: United States
facility: Penn State University Milton S Hershey Medical Center
state: Pennsylvania
city: Providence
country: United States
facility: Local Institution - 253
state: Rhode Island
city: Charleston
country: United States
facility: Local Institution - 289
state: South Carolina
city: Orangeburg
country: United States
facility: Local Institution - 212
state: South Carolina
city: Nashville
country: United States
facility: Local Institution - 121
state: Tennessee
city: Nashville
country: United States
facility: Vanderbilt University Medical Center
state: Tennessee
city: Union City
country: United States
facility: Advanced Gastroenterology
state: Tennessee
city: Austin
country: United States
facility: Local Institution - 158
state: Texas
city: Fort Sam Houston
country: United States
facility: Local Institution - 034
state: Texas
city: Houston
country: United States
facility: Local Institution - 056
state: Texas
city: Houston
country: United States
facility: Local Institution - 150
state: Texas
city: Houston
country: United States
facility: Biopharma Informatic Inc. Research Center
state: Texas
city: Houston
country: United States
facility: Centex Studies, Inc.
state: Texas
city: Houston
country: United States
facility: GI Specialists of Houston
state: Texas
city: Houston
country: United States
facility: Local Institution - 303
state: Texas
city: Houston
country: United States
facility: Local Institution - 088
state: Texas
city: Houston
country: United States
facility: Local Institution - 196
state: Texas
city: Houston
country: United States
facility: Gulf Coast Research Group LLC
state: Texas
city: Pasadena
country: United States
facility: Accurate Clinical Research Inc
state: Texas
city: Richardson
country: United States
facility: Local Institution - 071
state: Texas
city: San Antonio
country: United States
facility: Local Institution - 085
state: Texas
city: San Antonio
country: United States
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state: Texas
city: San Antonio
country: United States
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state: Texas
city: Southlake
country: United States
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state: Texas
city: Temple
country: United States
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state: Texas
city: Tyler
country: United States
facility: Local Institution - 073
state: Texas
city: Riverton
country: United States
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state: Utah
city: Salt Lake City
country: United States
facility: Local Institution - 025
state: Utah
city: Gainesville
country: United States
facility: Local Institution - 189
state: Virginia
city: Lynchburg
country: United States
facility: Local Institution - 030
state: Virginia
city: Manassas
country: United States
facility: Local Institution - 298
state: Virginia
city: Petersburg
country: United States
facility: Summit Clinical Research, LLC
state: Virginia
city: Reston
country: United States
facility: The Gastroenterology Group
state: Virginia
city: Richmond
country: United States
facility: Local Institution - 072
state: Virginia
city: Roanoke
country: United States
facility: Local Institution - 172
state: Virginia
city: Suffolk
country: United States
facility: Virginia Gastroenterology Institute PC
state: Virginia
city: Williamsburg
country: United States
facility: Local Institution - 296
state: Virginia
city: Spokane
country: United States
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state: Washington
city: Grafton
country: United States
facility: Aurora Health Care Aurora Research
state: Wisconsin
city: La Crosse
country: United States
facility: Local Institution - 089
state: Wisconsin
city: Buenos Aires
country: Argentina
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city: Buenos Aires
country: Argentina
facility: Local Institution - 571
city: Buenos Aires
country: Argentina
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city: Ciudad Autonoma de Buenos Aires
country: Argentina
facility: Local Institution - 494
city: Cordoba
country: Argentina
facility: Local Institution - 570
city: Cordoba
country: Argentina
facility: Local Institution - 495
city: Mar del Plata
country: Argentina
facility: Local Institution - 569
city: Rosario, Santa Fe
country: Argentina
facility: Local Institution - 502
city: Rosario
country: Argentina
facility: Local Institution - 496
city: Rosario
country: Argentina
facility: Local Institution - 497
city: San Miguel de Tucuman
country: Argentina
facility: Local Institution - 492
city: Concord
country: Australia
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state: New South Wales
city: Kingswood
country: Australia
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state: New South Wales
city: Liverpool
country: Australia
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state: New South Wales
city: New Lambton Heights
country: Australia
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state: New South Wales
city: Wollongong
country: Australia
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state: New South Wales
city: Herston
country: Australia
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state: Queensland
city: Maroorchydore
country: Australia
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state: Queensland
city: North Mackay
country: Australia
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state: Queensland
city: South Brisbane
country: Australia
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state: Queensland
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facility: Local Institution - 708
state: South Australia
city: Bedford Park
country: Australia
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state: South Australia
city: Elizabeth Vale
country: Australia
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state: South Australia
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country: Australia
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city: Fitzroy
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city: Geelong
country: Australia
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state: Victoria
city: Melbourne
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country: Austria
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country: Belarus
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country: Bosnia and Herzegovina
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country: Bulgaria
facility: Local Institution - 456
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country: Bulgaria
facility: Local Institution - 746
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country: Bulgaria
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city: Sofia
country: Bulgaria
facility: Local Institution - 747
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country: Bulgaria
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city: Sofia
country: Bulgaria
facility: Local Institution - 755
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country: Bulgaria
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country: Bulgaria
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country: Bulgaria
facility: Local Institution - 754
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country: Canada
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state: Alberta
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country: Canada
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state: Alberta
city: Edmonton
country: Canada
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state: Alberta
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city: New Westminister
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state: British Columbia
city: Vancouver
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state: British Columbia
city: Vancouver
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country: Canada
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city: Winnipeg
country: Canada
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state: Manitoba
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country: Canada
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city: London
country: Canada
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city: London
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state: Ontario
city: Sudbury
country: Canada
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state: Ontario
city: Toronto
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state: Ontario
city: Toronto
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state: Ontario
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country: China
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country: China
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city: Guangzhou Shi
country: China
facility: Local Institution - 486
city: Guangzhou
country: China
facility: Local Institution - 478
city: Hangzhou, Zhejiang
country: China
facility: Local Institution - 470
city: Hefei
country: China
facility: Local Institution - 491
city: Kunming
country: China
facility: Local Institution - 374
city: Luzhou
country: China
facility: Local Institution - 383
city: Nanchang
country: China
facility: Local Institution - 488
city: Nanjing City
country: China
facility: Local Institution - 418
city: Nanjing
country: China
facility: Local Institution - 375
city: Nanjing
country: China
facility: Local Institution - 487
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country: China
facility: Local Institution - 473
city: Shanghai
country: China
facility: Local Institution - 380
city: Shanghai
country: China
facility: Local Institution - 416
city: Shanghai
country: China
facility: Local Institution - 377
city: Taichung City
country: China
facility: Local Institution - 458
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country: China
facility: Local Institution - 373
city: Wuhan Shi
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facility: Local Institution - 483
city: Wuhan
country: China
facility: Local Institution - 475
city: Wuhan
country: China
facility: Local Institution - 474
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country: China
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city: Xi'an
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city: Xi'an
country: China
facility: Local Institution - 420
city: Zhengzhou
country: China
facility: Local Institution - 370
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facility: Local Institution - 397
state: Quindio
city: Barranquilla
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facility: Local Institution - 395
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facility: Local Institution - 396
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country: Colombia
facility: Local Institution - 394
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facility: Local Institution - 453
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country: Croatia
facility: Local Institution - 763
city: Split
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facility: Local Institution - 765
city: Zagreb
country: Croatia
facility: Local Institution - 452
city: Zagreb
country: Croatia
facility: Local Institution - 762
city: Zagreb
country: Croatia
facility: Local Institution - 766
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facility: Local Institution - 767
city: Brno
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facility: Local Institution - 772
city: Hradec Králové
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facility: Local Institution - 773
city: Most
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facility: Local Institution - 775
city: Olomouc
country: Czechia
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city: Pardubice
country: Czechia
facility: Local Institution - 774
city: Plzen
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city: Prague 5
country: Czechia
facility: Local Institution - 768
city: Prague 9
country: Czechia
facility: Local Institution - 770
city: Prague
country: Czechia
facility: Local Institution - 573
city: Prague
country: Czechia
facility: Local Institution - 368
city: Praha 4
country: Czechia
facility: Local Institution - 776
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facility: Local Institution - 611
city: Holbaek
country: Denmark
facility: Local Institution - 610
city: Nykobing F
country: Denmark
facility: Local Institution - 609
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facility: Local Institution - 613
city: Turku
country: Finland
facility: Local Institution - 614
city: Neuilly-sur-Seine
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facility: Local Institution - 647
state: Cedex
city: Amiens cedex 1
country: France
facility: Local Institution - 638
city: Blois Cedex
country: France
facility: Local Institution - 635
city: Béziers
country: France
facility: Local Institution - 639
city: Caen
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facility: Local Institution - 634
city: Colombes
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facility: Local Institution - 644
city: Creteil Cedex
country: France
facility: Local Institution - 711
city: Dijon Cedex
country: France
facility: Local Institution - 616
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country: France
facility: Local Institution - 615
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facility: Local Institution - 633
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country: France
facility: Local Institution - 646
city: Montpellier
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facility: Local Institution - 507
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facility: Local Institution - 632
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facility: Local Institution - 630
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facility: Local Institution - 641
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facility: Local Institution - 612
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facility: Local Institution - 631
city: Toulouse Cedex 09
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facility: Local Institution - 643
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city: Tbilisi
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facility: Local Institution - 454
city: Tbilisi
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facility: Local Institution - 783
city: Tbilisi
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city: Tbilisi
country: Georgia
facility: Local Institution - 778
city: Tbilisi
country: Georgia
facility: Local Institution - 782
city: Tbilisi
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city: Tbilisi
country: Georgia
facility: Local Institution - 781
city: Tbilisi
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facility: Local Institution - 793
city: Tbilisi
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facility: Local Institution - 740
city: Tbilisi
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facility: Local Institution - 784
city: Tbilisi
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facility: Local Institution - 785
city: Tbilisi
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city: Tbilisi
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city: Tbilisi
country: Georgia
facility: Local Institution - 455
city: Telavi
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facility: Local Institution - 780
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facility: Local Institution - 626
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facility: Local Institution - 629
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facility: Local Institution - 665
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facility: Local Institution - 653
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facility: Local Institution - 648
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facility: Local Institution - 650
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facility: Local Institution - 628
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facility: Local Institution - 664
city: Dachau
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facility: Local Institution - 732
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facility: Local Institution - 574
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facility: Local Institution - 657
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facility: Local Institution - 662
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facility: Local Institution - 654
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city: Halle
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facility: Local Institution - 651
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facility: Local Institution - 655
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facility: Local Institution - 730
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facility: Local Institution - 660
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facility: Local Institution - 667
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facility: Local Institution - 661
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facility: Local Institution - 666
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city: Athens
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facility: Local Institution - 797
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facility: Local Institution - 800
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facility: Local Institution - 799
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facility: Local Institution - 816
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facility: Local Institution - 805
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facility: Local Institution - 344
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facility: Local Institution - 342
city: Rechovot
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facility: Local Institution - 338
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facility: Local Institution - 340
city: Bologna
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facility: Local Institution - 677
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facility: Local Institution - 684
city: Brescia
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facility: Local Institution - 688
city: Castellana Grotte
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facility: Local Institution - 689
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facility: Local Institution - 679
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facility: Local Institution - 674
city: Milano
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facility: Local Institution - 686
city: Milano
country: Italy
facility: Local Institution - 334
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facility: Local Institution - 672
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facility: Local Institution - 685
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facility: Local Institution - 682
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facility: Local Institution - 673
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facility: Local Institution - 681
city: Roma
country: Italy
facility: Local Institution - 675
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facility: Local Institution - 671
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facility: Local Institution - 680
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facility: Local Institution - 670
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country: Italy
facility: Local Institution - 676
city: Ansan
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facility: Local Institution - 437
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facility: Local Institution - 441
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facility: Local Institution - 434
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facility: Local Institution - 431
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facility: Local Institution - 430
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facility: Local Institution - 438
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facility: Local Institution - 427
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facility: Local Institution - 600
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facility: Local Institution - 603
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facility: Local Institution - 607
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facility: Local Institution - 606
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facility: Local Institution - 604
city: Zapapan
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facility: Local Institution - 525
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facility: Local Institution - 447
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facility: Local Institution - 449
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facility: Local Institution - 529
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facility: Local Institution - 809
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facility: Local Institution - 949
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facility: Local Institution - 951
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country: Poland
facility: Local Institution - 597
state: Lubelskie
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facility: Local Institution - 820
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facility: Local Institution - 818
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facility: Local Institution - 580
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facility: Local Institution - 988
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facility: Local Institution - 579
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facility: Local Institution - 978
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facility: Local Institution - 577
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facility: Local Institution - 757
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facility: Local Institution - 828
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facility: Local Institution - 819
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facility: Local Institution - 823
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facility: Local Institution - 979
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facility: Local Institution - 835
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facility: Local Institution - 235
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facility: Local Institution - 822
city: Tychy
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facility: Local Institution - 824
city: Ul. Piotrkowska 177
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facility: Local Institution - 827
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facility: Local Institution - 833
city: Warsaw
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facility: Local Institution - 989
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city: Wroclaw
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facility: Local Institution - 832
city: Coimbra
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facility: Local Institution - 961
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city: Bucharest
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city: Bucharest
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facility: Local Institution - 499
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city: Bucharest
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city: Bratislava
country: Slovakia
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city: Brezno
country: Slovakia
facility: Local Institution - 895
city: Nitra
country: Slovakia
facility: Local Institution - 899
city: Nove Zamky
country: Slovakia
facility: Local Institution - 897
city: Presov
country: Slovakia
facility: Local Institution - 898
city: Rimavska Sobota
country: Slovakia
facility: Local Institution - 896
city: Celje
country: Slovenia
facility: Local Institution - 904
city: Gauteng
country: South Africa
facility: Local Institution - 543
city: Kempton Park
country: South Africa
facility: Local Institution - 545
city: Pretoria
country: South Africa
facility: Local Institution - 544
city: Pretoria
country: South Africa
facility: Local Institution - 542
city: Pretoria
country: South Africa
facility: Local Institution - 549
city: Somerset West
country: South Africa
facility: Local Institution - 548
city: Val De Grace
country: South Africa
facility: Local Institution - 547
city: Alicante
country: Spain
facility: Local Institution - 703
city: Badalona
country: Spain
facility: Local Institution - 690
city: Barcelona
country: Spain
facility: Local Institution - 694
city: Cordoba
country: Spain
facility: Local Institution - 702
city: Girona
country: Spain
facility: Local Institution - 699
city: La Laguna
country: Spain
facility: Local Institution - 698
city: Las Palmas de Gran Canaria
country: Spain
facility: Local Institution - 701
city: Madrid
country: Spain
facility: Local Institution - 691
city: Madrid
country: Spain
facility: Local Institution - 695
city: Madrid
country: Spain
facility: Local Institution - 692
city: Majadahonda, Madrid
country: Spain
facility: Local Institution - 693
city: Santander
country: Spain
facility: Local Institution - 706
city: Sevilla
country: Spain
facility: Local Institution - 696
city: Sevilla
country: Spain
facility: Local Institution - 705
city: Valencia
country: Spain
facility: Local Institution - 697
city: Viladecans
country: Spain
facility: Local Institution - 700
city: Stockholm
country: Sweden
facility: Local Institution - 625
city: Bern
country: Switzerland
facility: Local Institution - 967
city: St.Gallen
country: Switzerland
facility: Local Institution - 968
city: Zurich
country: Switzerland
facility: Local Institution - 969
city: Kaohsiung, San Ming Dist.
country: Taiwan
facility: Local Institution - 463
city: Kaohsiung
country: Taiwan
facility: Local Institution - 460
city: Kozlu
country: Taiwan
facility: Local Institution - 363
city: Niao-Sung Hsiang Kaohsiung County
country: Taiwan
facility: Local Institution - 461
city: Tainan, Taiana
country: Taiwan
facility: Local Institution - 459
city: Taipei
country: Taiwan
facility: Local Institution - 465
city: Taoyuan City
country: Taiwan
facility: Local Institution - 462
city: Tapei, Beitou Dist.
country: Taiwan
facility: Local Institution - 464
city: Ankara
country: Turkey
facility: Local Institution - 357
city: Ankara
country: Turkey
facility: Local Institution - 356
city: Bursa
country: Turkey
facility: Local Institution - 360
city: Elazig
country: Turkey
facility: Local Institution - 365
city: Istanbul
country: Turkey
facility: Local Institution - 362
city: Istanbul
country: Turkey
facility: Local Institution - 358
city: Istanbul
country: Turkey
facility: Local Institution - 361
city: Istanbul
country: Turkey
facility: Local Institution - 355
city: Izmit/Kocaeli
country: Turkey
facility: Local Institution - 354
city: Kadiköy/Istanbul
country: Turkey
facility: Local Institution - 353
city: Trabzon
country: Turkey
facility: Local Institution - 359
city: Chernivtsi
country: Ukraine
facility: Local Institution - 914
city: Chernivtsi
country: Ukraine
facility: Local Institution - 922
city: Dnipropetrovsk
country: Ukraine
facility: Local Institution - 950
city: Ivano-Frankivsk
country: Ukraine
facility: Local Institution - 229
city: Ivano-Frankivsk
country: Ukraine
facility: Local Institution - 929
city: Ivano-Frankivsk
country: Ukraine
facility: Local Institution - 912
city: Kharkiv
country: Ukraine
facility: Local Institution - 919
city: Kharkiv
country: Ukraine
facility: Local Institution - 965
city: Khmelnytskyi
country: Ukraine
facility: Local Institution - 920
city: Kropyvnytskyi
country: Ukraine
facility: Local Institution - 933
city: Kyiv
country: Ukraine
facility: Local Institution - 901
city: Kyiv
country: Ukraine
facility: Local Institution - 923
city: Kyiv
country: Ukraine
facility: Local Institution - 915
city: Kyiv
country: Ukraine
facility: Local Institution - 243
city: Kyiv
country: Ukraine
facility: Local Institution - 563
city: Kyiv
country: Ukraine
facility: Local Institution - 911
city: Kyiv
country: Ukraine
facility: Local Institution - 244
city: Kyiv
country: Ukraine
facility: Local Institution - 564
city: Kyiv
country: Ukraine
facility: Local Institution - 918
city: Kyiv
country: Ukraine
facility: Local Institution - 908
city: Kyiv
country: Ukraine
facility: Local Institution - 977
city: Kyiv
country: Ukraine
facility: Local Institution - 562
city: Lutsk
country: Ukraine
facility: Local Institution - 240
city: Lutsk
country: Ukraine
facility: Local Institution - 590
city: Lviv
country: Ukraine
facility: Local Institution - 234
city: Lviv
country: Ukraine
facility: Local Institution - 974
city: Lviv
country: Ukraine
facility: Local Institution - 910
city: Odesa
country: Ukraine
facility: Local Institution - 242
city: Odesa
country: Ukraine
facility: Local Institution - 902
city: Poltava
country: Ukraine
facility: Local Institution - 905
city: Ternopil
country: Ukraine
facility: Local Institution - 934
city: Vinnytsia
country: Ukraine
facility: Local Institution - 909
city: Vinnytsia
country: Ukraine
facility: Local Institution - 224
city: Vinnytsia
country: Ukraine
facility: Local Institution - 924
city: Vinnytsia
country: Ukraine
facility: Local Institution - 971
city: Vinnytsya
country: Ukraine
facility: Local Institution - 932
city: Zaporizhia
country: Ukraine
facility: Local Institution - 587
city: Zaporizhzhya
country: Ukraine
facility: Local Institution - 925
city: Southampton
country: United Kingdom
facility: Local Institution - 723
state: Hampshire
city: London
country: United Kingdom
facility: Local Institution - 729
state: LND
city: Birmingham
country: United Kingdom
facility: Local Institution - 557
city: Bristol
country: United Kingdom
facility: Local Institution - 714
city: Cardiff
country: United Kingdom
facility: Local Institution - 560
city: Chorley
country: United Kingdom
facility: Local Institution - 558
city: Corbridge Road
country: United Kingdom
facility: Local Institution - 559
city: Dundonald
country: United Kingdom
facility: Local Institution - 712
city: Glasgow
country: United Kingdom
facility: Local Institution - 713
city: Lancashire Blackpool
country: United Kingdom
facility: Local Institution - 716
city: London
country: United Kingdom
facility: Local Institution - 722
city: London
country: United Kingdom
facility: Local Institution - 715
city: North Manchester Science Park
country: United Kingdom
facility: Local Institution - 561
city: Shrewsbury
country: United Kingdom
facility: Local Institution - 593
city: Torquay
country: United Kingdom
facility: Local Institution - 718
Study officials:
affiliation: Bristol-Myers Squibb
name: Bristol-Myers Squibb
role: STUDY_DIRECTOR
References:
citation: Feagan BG, Schreiber S, Afzali A, Rieder F, Hyams J, Kollengode K, Pearlman J, Son V, Marta C, Wolf DC, D'Haens GG. Ozanimod as a novel oral small molecule therapy for the treatment of Crohn's disease: The YELLOWSTONE clinical trial program. Contemp Clin Trials. 2022 Nov;122:106958. doi: 10.1016/j.cct.2022.106958. Epub 2022 Oct 5.