Clinical trial NCT05284331: Outcome of Old Patient With Articular With Articular Implant Infection
Official title: Outcome of Old Patient With Articular With Articular Implant Infection
Study type: INTERVENTIONAL
Overall status: TERMINATED
Phase: NA
Conditions: Complications; Implant, Orthopedic, Infection or Inflammation
Keywords: Articular Implant Infection
Lead sponsor: Centre Hospitalier Metropole Savoie
Sponsor class: OTHER
First posted: 2022-03-17
Enrollment: 3
Sex: ALL
Minimum age (years): 75
Standard ages: OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: OTHER

Brief summary: Articular Implant Infection (AII) is itself a complicated diagnosis and a challenging condition to treat. In elderly patients, the application of existing recommendations is impeded by multiple frailties For a better knowledge of the long-term consequences of AII in elderly patient, the investigators conduct a prospective, multicentric study, whitch aim this is to better evaluate the burden of AII on elderly patients, in terms of quality of life. Secondly, the investigators would like to identify the factors that influence the prognosis, in order to guide further prospective research.

Detailed description: Articular Implant Infection (AII) is itself a complicated diagnosis (diagnosis confirmation, pathogen identification, with appropriate samples) and a challenging condition to treat (long antibiotic exposure, repeated surgery, complex implant change). This condition requires a good cooperation between surgeon and infectious disease specialist, with a comprehension of each one's constraint. In elderly patients, the application of existing recommendations is impeded by multiple frailties (malnutrition, loss of autonomy, polypathology) which make each decision crucial. Indeed, from the choice of surgery to antibiotics management, all medical decision can induce more adverse events than in younger patients. For a better knowledge of the long-term consequences of AII in elderly patient, the investigators conduct a prospective, multicentric study, based on the evaluation of the EQ-5D-5L score during one year after AAI diagnosis in patients older than 75. The investigators evaluate this score and compare different groups of patients, according to age, nutrition status, Charlson comorbidity index, hospital stay length, and loss of autonomy, among others. The aim of this study is to better evaluate the burden of AII on elderly patients, in terms of quality of life. Secondly, the investigators would like to identify the factors that influence the prognosis, in order to guide further prospective research.

Eligibility criteria: Inclusion Criteria:

* hospitalized in infectious diseases, surgery, post-emergency unit, or geriatrics,
* diagnosed with a hip or knee prosthesis infection in the previous month according to the SPILF criteria (2009)(1).

Exclusion Criteria:

* Above criteria not met,
* Patient refusal,
* Mild cognitive impairment or more significant.

Primary outcomes:
measure: Changes in the EQ-5D-5L quality of life score
timeFrame: 1 year
measure: Changes in the EQ-5D-VAS assessing the patient's general condition, completed by the patient
timeFrame: 1 year
Secondary outcomes:
Other outcomes:
Locations:
city: Chambéry
country: France
facility: Centre Hospitalier Métropole Savoie
Study officials:
affiliation: Centre Hospitalier Metropole Savoie
name: PEJU Martin, Physician
role: PRINCIPAL_INVESTIGATOR
References: