Clinical trial NCT06920017: Demographic Data and Clinical Presentation of Pediatric Uveitis
Official title: Demographic Data and Clinical Presentation of Pediatric Uveitis Patients in Upper Egypt.
Study type: OBSERVATIONAL
Overall status: NOT_YET_RECRUITING
Conditions: Pediatric Uveitis
Lead sponsor: Assiut University
Sponsor class: OTHER
First posted: 2025-04-09
Enrollment: 40
Sex: ALL
Maximum age (years): 18
Standard ages: CHILD
ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: pediatric patients

Brief summary: To describe and analyze the demographics, Clinical characteristics, etiology, and visual outcomes of pediatric uveitis cases attending the outpatient clinic of Ophthalmology department, Assiut University Hospital.

Detailed description: Uveitis is a form of eye inflammation that affects the middle layer of tissue in the eye wall (uvea).

It is the third leading cause of blindness worldwide .Uveitis is more common in adults; however, children comprise 2.2% to 21.6% of patients in various studies.Despite a lower incidence of uveitis in children, the rate of visual loss may be worse than that of adults . The onset of uveitis in children is often insidious and is only discovered during routine screening.The lack of significant symptoms and delayed presentation to an ophthalmologist leads to morbidity and a decrease in visual acuity . The length of time between the diagnosis of uveitis and the referral to a tertiary eye center is strongly correlated with the complications rate and degree of visual impairment.

Uveitis is classified according to the International Uveitis Study Group criteria based on the anatomical location of the inflammation and is categorized as anterior, intermediate, Posterior or panuveitis. It is also described based on clinical onset, duration and course.

Some uveitis syndromes are unique to children, such as juvenile idiopathic arthritis (JIA), Kawasaki syndrome, Familial Juvenile Systemic Granulomatosis and Tubulointerstitial Nephritis-Uveitis syndrome. Other conditions are more prevalent in the pediatric population due to environmental factors such as trematode induced uveitis.

Due to the lack of epidemiological studies on the demographic and Clinical Characteristics of pediatric uveitis in Upper Egypt. This study aims to improve diagnosis, management, and treatment strategies tailored to the population.

Eligibility criteria: Inclusion Criteria:

* Uveitis patients \<18 years old
* must be able to participate in the study.

Exclusion Criteria:

* Age over 18 years.
* Patients with post pentrating ocular trauma.
* Patients whose legal guardians are unwilling to participate in the study.

Primary outcomes:
measure: Distribution of uveitis subtypes.
timeFrame: Baseline
measure: Differences by age, gender, or ethnicity.
timeFrame: Baseline
measure: Prevalence of systemic associations.
timeFrame: Baseline
measure: Prevalence of Visual outcomes.
timeFrame: Baseline
measure: Prevalence of complications rate.
timeFrame: Baseline
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
affiliation: Assiut University
name: Mohamed Sharaf El Din Abd El Rahim, professor
role: STUDY_DIRECTOR
affiliation: Assiut University
name: Mohmed Gamal Ahmed Saleh, Assistant Professor
role: STUDY_DIRECTOR
affiliation: Assiut University
name: Eslam Mohamed Mohamed Goda, Lecturer
role: STUDY_DIRECTOR
References:
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citation: American Academy of Ophthalmology meeting (Uveitis and Ocular Inflammation section), October 25, 2004; New Orleans, Louisiana
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citation: Kump LI, Cervantes-Castaneda RA, Androudi SN, Foster CS. Analysis of pediatric uveitis cases at a tertiary referral center. Ophthalmology. 2005 Jul;112(7):1287-92. doi: 10.1016/j.ophtha.2005.01.044.
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