Clinical trial NCT07017075: TEE Guided Adjusting CPR Location
Official title: 3D Visulization The Area Of Maximal Compression And Quantitative Assessment Stroke Volume And Ejection Fraction After Adjusting CPR Location
Study type: INTERVENTIONAL
Overall status: ENROLLING_BY_INVITATION
Phase: NA
Conditions: Cardiac Arrest (CA)
Keywords: OHCA
TEE
Lead sponsor: National Taiwan University Hospital
Sponsor class: OTHER
Collaborators: name: Chang Bing Show Chwan Memorial Hospital
First posted: 2025-06-12
Enrollment: 50
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: TREATMENT

Brief summary: Use Transesophageal ultrasound in OHCA patients to identify the proper compression location

Detailed description: For patients with cardiac arrest, high-quality cardiopulmonary resuscitation is performed according to critical care management and Advanced Cardiac Life Support (ACLS). Rapid with powerful chest compression should be performed to maintain the heart's output and blood flow. An advanced airway should be established and adjust resuscitation based on collected clinical information. Transesophageal ultrasound examination is performed after the advanced airway is established without affecting the resuscitation. The investigators use the built-in ultrasound software (Philips QLAB 3D quantification advance, Philips Healthcare, USA, speckle tracking echocardiography (STE,Speckle tracking echocardiography)) to analyze stroke volume and cardiac output. The investigators collect the stroke volume and cardiac output at the chest compression position recommended by ACLS, as well as the stroke volume and cardiac output after adjusting the optimal chest compression position. The investigators expect it can increase the return of spontaneous circulation rate, survival rate, and neurological prognosis over time.

Eligibility criteria: Inclusion Criteria:

* Out of hospital cardiac arrest patients

Exclusion Criteria:

* DNR was signed
* Age under 18
* Trauma patients
* Patients hard to establish advanced airway

Primary outcomes:
measure: cardiac output
timeFrame: 2 mins
measure: stroke volume
timeFrame: 2 mins
Secondary outcomes:
Other outcomes:
Locations:
city: Changhua
country: Taiwan
facility: Chang Bing Show Chawan Memorial Hospital
city: Taipei
country: Taiwan
facility: National Taiwan University Hospital
Study officials:
affiliation: National Taiwan University Hospital
name: WANCHING LIEN
role: STUDY_DIRECTOR
References:
citation: Chen CC, Huang CS, Yen HT, Lien WC. A visualization of ejection fraction change after adjusting the area of maximal compression. Resuscitation. 2024 Jan;194:110097. doi: 10.1016/j.resuscitation.2023.110097. Epub 2023 Dec 20. No abstract available.
citation: Teran F, Owyang CG, Martin-Flores M, Lao D, King A, Palasz J, Araos JD. Hemodynamic impact of chest compression location during cardiopulmonary resuscitation guided by transesophageal echocardiography. Crit Care. 2023 Aug 19;27(1):319. doi: 10.1186/s13054-023-04575-7. No abstract available.
citation: Hwang SO, Zhao PG, Choi HJ, Park KH, Cha KC, Park SM, Kim SC, Kim H, Lee KH. Compression of the left ventricular outflow tract during cardiopulmonary resuscitation. Acad Emerg Med. 2009 Oct;16(10):928-33. doi: 10.1111/j.1553-2712.2009.00497.x. Epub 2009 Sep 3.
citation: Olasveengen TM, Semeraro F, Ristagno G, Castren M, Handley A, Kuzovlev A, Monsieurs KG, Raffay V, Smyth M, Soar J, Svavarsdottir H, Perkins GD. European Resuscitation Council Guidelines 2021: Basic Life Support. Resuscitation. 2021 Apr;161:98-114. doi: 10.1016/j.resuscitation.2021.02.009. Epub 2021 Mar 24.