Clinical trial NCT02913365: Etiologies, Investigations and Outcomes of Patients Presenting With Hemoptysis
Official title: Etiologies, Investigations and Outcomes of Patients Presenting With Hemoptysis in a North-American Tertiary Center at the Beginning of the 21st Century
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Hemoptysis
Haemoptysis
Lung Disease
Pneumonia
Tuberculosis
Bronchiectasis
Respiratory Tract Infections
Respiratory Tract Diseases
Bronchitis
Mycobacterium Infections
Bronchial Disease
Pulmonary Hemorrhage
Signs and Symptoms
Signs and Symptoms, Respiratory
Pathologic Processes
Mycosis
Hemorrhage
Lung Cancer
Pulmonary Embolism
Arteriovenous Fistula
Keywords: Haemoptysis
Hemoptysis
Airway bleeding
Pulmonary hemorrhage
Lead sponsor: Université de Sherbrooke
Sponsor class: OTHER
First posted: 2016-09-23
Enrollment: 1000
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: RETROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: Any patient presenting with hemoptysis at the Centre Hospitalier Universitaire de Sherbrooke on an outpatient basis, emergency department or hospitalized at hopital Fleurimont or Hotel-Dieu of Sherbrooke.

Brief summary: The study consist of a retrospective analysis of the etiologies, investigations and outcomes of patients presenting between 2005 to 2010 with hemoptysis in a North-American Tertiary center.

Detailed description: RATIONALE:

Hemoptysis, mild or massive, is worrisome for both patients and physicians. The management is different depending on the causes, which are not well defined for the North American population. Despite the fact that this symptom is commonly reported in clinic, there are only a few studies published on this subject in the North-American population. Tuberculosis was a frequent cause of hemoptysis described in populations overseas, which seems less prevalent in the investigators center.

Also, there are no known official guidelines regarding the investigation and management of hemoptysis. The investigators hypothesized that the use of modern technology in a North American population may result in different findings and provide a more accurate diagnostic approach.

Therefore, the study compares the different etiologies of hemoptysis and investigation modalities used in patients presenting in a North-American tertiary center.

METHOD:

The investigators did a retrospective analysis of medical chart from patients with hemoptysis who visited the investigators center between 2005 and 2010. Each visit has been reviewed individually to describe the characteristics of patients, etiologies of hemoptysis and investigation modalities used. All-cause mortality at 2 years was also recorded.

Descriptive statistical analyses will conducted on the data available.

Eligibility criteria: Inclusion Criteria:

Any patient over the age of 18 presenting with:

* A diagnosis of hemoptysis on an outpatient basis.
* A diagnosis of hemoptysis during consultation in the emergency department.
* A diagnosis of hemoptysis on the admission sheet.
* A diagnosis of hemoptysis when hospitalized.
* A complication of hemoptysis
* Hemoptysis on the report of the bronchoscopy, chest computed tomography, pulmonary angiography, ventilation-perfusion single-photon emission computed tomography or blood transfusion.

Exclusion Criteria:

* Patients under 18 years of age.
* Patient who refused investigation for hemoptysis.
* Incomplete medical chart

Primary outcomes:
measure: Etiologies of hemoptysis
timeFrame: 5 years
Secondary outcomes:
measure: Sensitivity of chest X-ray, chest CT-scan and CT-angiography, bronchoscopy, ventilation-perfusion with single-photon emission computed tomography and pulmonary angiography.
timeFrame: 5 years
measure: All-cause mortality at 2 years
timeFrame: 2 years
measure: Smoking status
timeFrame: Day 1
measure: Age
timeFrame: Day 1
measure: Gender
timeFrame: Day 1
measure: International Normalized Ratio
timeFrame: Day 1
measure: Partial Thromboplastin Time
timeFrame: Day 1
measure: Platelet count
timeFrame: Day 1
Other outcomes:
Locations:
city: Sherbrooke
country: Canada
facility: Centre Hospitalier Universitaire de Sherbrooke
state: Quebec
Study officials:
affiliation: Université de Sherbrooke
name: Brian Grodin-Beaudoin, MD
role: PRINCIPAL_INVESTIGATOR
References:
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