Clinical trial NCT05677165: The Relationship Between Driving Pressure, Mechanical Power, Oxygenation and Saturation Indices: Retrospective Observational Study
Official title: The Relationship Between Driving Pressure, Mechanical Power, Oxygenation and Saturation Indices: Retrospective Observational Study
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Acute Respiratory Distress Syndrome
Pneumonia
Keywords: acute respiratory distress syndrome
pneumonia
oxygenation index
saturation index
Lead sponsor: Bakirkoy Dr. Sadi Konuk Research and Training Hospital
Sponsor class: OTHER_GOV
First posted: 2023-01-10
Enrollment: 361
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: OTHER
Time perspective: RETROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: The data of 784 patients with a diagnosis of Covid-19 hospitalized in the 28-bed intensive care unit of the Bakirkoy Dr. Sadi Konuk Training and Research Hospital were obtained by using structured query language (sql) queries from the 'ImdSoft-Metavision/QlinICU Clinical Decision Support (Israel) system'.173 patients who did not receive invasive mechanical ventilation support, 64 patients who stayed in the intensive care unit for less than 24 hours, 40 patients with missing data, and 38 patients who received mechanical ventilation support for less than 24 hours were excluded from the study.24 patients with COPD, 27 patients with congestive heart failure, and 11 patients who underwent tube thoracostomy due to tension pneumothorax were excluded from the study.In addition, 46 patients who received ECMO support were excluded from the study due to the possibility that ECMO may have an effect on respiratory variables. The remaining 361 patients were included in the study.

Brief summary: By using Mechanical Power and Driving Pressure instead of Pmean we calculate new oxygen saturation indices like Driving Pressure Oxygen Index (OIDP), Dynamic Power Oxygen Index (OIMPdyn), Total Power Oxygen Index (OIMPtot), Driving Pressure Saturation Index (OSIDP), Dynamic Power Saturation Index (OSIMPdyn) ve Power Saturation Index (OSIMPtot).

New oxygenation and saturation indices are able to predict ICU mortality better than the conventional indexes and rates.


Eligibility criteria: Inclusion Criteria:

- Patients with a diagnosis of Covid-19 related Acute Respiratory Syndrome (C-ARDS) which hospitalized in Bakirköy Dr. Sadi Konuk Training and Research Hospital intensive care unit

Exclusion Criteria:

* Patients who did not receive invasive mechanical ventilation support.
* Patients who stayed in the intensive care unit for less than 24 hours.
* Patients with missing data
* Patients who received mechanical ventilation support for less than 24 hours
* Patients with Chronic Obstructive Pulmonary Disease (COPD).
* Patients with congestive heart failure
* Patients who underwent tube thoracostomy due to tension pneumothorax
* Patients who received Extracorporeal Membrane Oxygenation (ECMO) support

Primary outcomes:
measure: In hospital mortality
timeFrame: 28 days
Secondary outcomes:
measure: Mechanical ventilatory free days
timeFrame: 30 days
Other outcomes:
Locations:
city: Istanbul
country: Turkey
facility: Bakirköy Dr sadi konuk Education hospital
Study officials:
References: