Clinical trial NCT02932124: Application of Mechanical Cardiopulmonary Resuscitation Devices and Their Value in Out-of-hospital Cardiac Arrest: A Retrospective Analysis of the German Resuscitation Registry
Official title: Application of Mechanical Cardiopulmonary Resuscitation Devices and Their Value in Out-of-hospital Cardiac Arrest: A Retrospective Analysis of the German Resuscitation Registry
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Out-of-hospital Cardiac Arrest
Keywords: German Resuscitation Registry
out-of-hospital cardiac arrest
cardiopulmonary resuscitation
mechanical chest compression devices
Lead sponsor: German Resuscitation Registry
Sponsor class: OTHER
First posted: 2016-10-13
Enrollment: 19609
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Patient suffering OHCA and be resuscitated by EMS where the data were delivered to the German Resuscitation Registry

Brief summary: The aim of this study was to analyse a large CPR database, the German Resuscitation Registry, to evaluate potential benefits of mechanical CPR devices over manual CPR in adult cardiac arrest victims. The primary endpoint considered is ROSC.

Detailed description: In a retrospective analysis of the German Resuscitation Registry between 2007-2014, investigators examined the outcome after using mechanical CPR on return of spontaneous circulation (ROSC) in adults with out-of-hospital cardiac arrest (OHCA). Investigators compared mechanical CPR (Intervention group) to manual CPR (control group). According to preclinical risk factors, investigators calculated the predicted ROSC-after-cardiac-arrest (RACA) score for each group, and compared it to the rate of ROSC observed. Using multivariate analysis, investigators adjusted the influence of the devices' application on ROSC for epidemiological factors and therapeutic measures.

Eligibility criteria: Inclusion Criteria:

* out of hospital cardiac arrest
* during time prod from January 2007 until December 2014
* CPR attempted

Exclusion Criteria:

* Investigators excluded cases in which CPR was continued for less than five minutes, or duration of CPR was missing, as the outcome in this early period is not affected by the CPR mode.
* Children aged less than 18 years and patients of unknown age were also excluded as the devices are not approved for resuscitation on children.
* An active compression-decompression (ACD) is a hand-held suction device, to compress and actively decompress the chest after each compression.
* Investigators also excluded cases where ACD CPR was used, because it constitutes a different technology.
* Cases due to trauma were excluded as application of mechanical CPR devices may be limited due in traumatic events.
* Cases where data on ROSC and/or CPR mode was missing were also excluded.

Primary outcomes:
measure: return of spontaneous circulation
timeFrame: sustained ROSC at any time latest after 24 hours
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
affiliation: German Resuscitation Registry
name: Jan Wnent, MD
role: PRINCIPAL_INVESTIGATOR
References: