Clinical trial NCT05519085: A Study to Evaluate Mezigdomide, Bortezomib and Dexamethasone (MEZIVd) Versus Pomalidomide, Bortezomib and Dexamethasone (PVd) in Participants With Relapsed or Refractory Multiple Myeloma (RRMM)
Official title: A Phase 3, Two-Stage, Randomized, Multicenter, Open-Label Study Comparing Mezigdomide (CC-92480), Bortezomib and Dexamethasone (MEZIVd) Versus Pomalidomide, Bortezomib and Dexamethasone (PVd) in Subjects With Relapsed or Refractory Multiple Myeloma (RRMM): SUCCESSOR-1
Study type: INTERVENTIONAL
Overall status: RECRUITING
Phase: PHASE3
Conditions: Relapsed or Refractory Multiple Myeloma
Keywords: Multiple myeloma
RRMM
MeziVd
PVd
CC92480
pomalidomide
bortezomib
dexamethasone
mezigdomide
Lead sponsor: Celgene
Sponsor class: INDUSTRY
First posted: 2022-08-29
Enrollment: 810
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The purpose of this study is to compare the efficacy and safety of mezigdomide (CC-92480), bortezomib and dexamethasone (MeziVd) versus pomalidomide, bortezomib and dexamethasone (PVd) in participants with relapsed or refractory multiple myeloma (RRMM) who received between 1 to 3 prior lines of therapy and who have had prior lenalidomide exposure.


Eligibility criteria: Inclusion Criteria

- Participant has documented diagnosis of MM and measurable disease, defined as any of the following:.

i) M-protein ≥ 0.5 grams per deciliter (g/dL) by serum protein electrophoresis (sPEP) or.

ii) M-protein ≥ 200 milligrams (mg) per 24-hour urine collection by urine protein electrophoresis (uPEP).

iii) For participants without measurable disease in sPEP or uPEP: serum free light chain (sFLC) levels \> 100 mg/L (10 mg/dL) involved light chain and an abnormal kappa/lambda FLC ratio.

* Participants received 1 to 3 prior lines of antimyeloma therapy.
* Participants achieved minimal response \[MR\] or better to at least 1 prior antimyeloma therapy.

Exclusion Criteria

- Participant has had progression during treatment or within 60 days of the last dose of a proteasome inhibitor, except as noted below:.

i) Subjects who progressed while being treated with, or within 60 days of last dose of bortezomib maintenance given once every 2 weeks (or less frequently) are not excluded.

ii) Participants who progressed while being treated with ixazomib monotherapy maintenance ≥ 6 months prior to the time of starting study treatment are not excluded.

* For participants with prior treatment of a bortezomib containing regimen, the best response achieved was not a minimal response (MR) or better, or participant discontinued bortezomib due to toxicity.
* Participant has had prior treatment with mezigdomide or pomalidomide.
* Other protocol-defined Inclusion/Exclusion criteria apply.

Primary outcomes:
measure: Progression-free Survival (PFS)
timeFrame: From date of randomization to date of disease progression or death due to any cause (Up to approximately 5 years)
Secondary outcomes:
measure: Recommended mezigdomide dose
timeFrame: Up to 12 Months
measure: Plasma concentrations of mezigdomide
timeFrame: Up to 134 Days
measure: Overall Survival (OS)
timeFrame: From date of randomization to date of death due to any cause (Up to approximately 5 years)
measure: Overall Response (OR)
timeFrame: Up to approximately 5 years
measure: Complete Response (CR) or better
timeFrame: Up to approximately 5 Years
measure: Very Good Partial Response (VGPR) or better
timeFrame: Up to approximately 5 years
measure: Time to Response (TTR)
timeFrame: Up to approximately 5 years
measure: Duration of Response (DOR)
timeFrame: Up to approximately 5 years
measure: Time to Progression (TTP)
timeFrame: Up to approximately 5 years
measure: Time to Next Treatment (TTNT)
timeFrame: Up to approximately 5 years
measure: Progression-free Survival 2 (PFS-2)
timeFrame: Up to approximately 5 years
measure: Minimal Residual Disease (MRD) negativity
timeFrame: Up to approximately 5 years
measure: Number of participants with Adverse Events (AEs)
timeFrame: Up to approximately 5 years
measure: Change from baseline in European Organization for Research and Treatment of Cancer - Quality of Life C30 questionnaire (EORTC QLQ-C30) scores
timeFrame: Up to approximately 5 years
measure: Change from baseline in European Organization for Research and Treatment of Cancer - Quality of Life Multiple Myeloma Module (EORTC QLQ-MY20) score
timeFrame: Up to approximately 5 years
Other outcomes:
Locations:
city: Los Alamitos
country: United States
facility: Cancer and Blood Specialty Clinic
state: California
city: San Diego
country: United States
facility: Sharp Memorial Hospital
state: California
city: West Hollywood
country: United States
facility: Private Practice - Dr. James R. Berenson
state: California
city: Aurora
country: United States
facility: Local Institution - 0381
state: Colorado
city: Farmington
country: United States
facility: UConn Health
state: Connecticut
city: New Haven
country: United States
facility: Local Institution - 0208
state: Connecticut
city: Coral Springs
country: United States
facility: Advanced Research
state: Florida
city: Fort Myers
country: United States
facility: Florida Cancer Specialists - South
state: Florida
city: Saint Petersburg
country: United States
facility: Florida Cancer Specialists - North
state: Florida
city: West Palm Beach
country: United States
facility: Florida Cancer Specialists - East
state: Florida
city: Athens
country: United States
facility: University Cancer Blood Ctr
state: Georgia
city: Marietta
country: United States
facility: Local Institution - 0048
state: Georgia
city: Garden City
country: United States
facility: Local Institution - 0330
state: Kansas
city: Westwood
country: United States
facility: University of Kansas Medical Center
state: Kansas
city: Baton Rouge
country: United States
facility: Our Lady of the Lake RMC
state: Louisiana
city: New Orleans
country: United States
facility: Tulane Cancer Center
state: Louisiana
city: Shreveport
country: United States
facility: Local Institution - 0385
state: Louisiana
city: Baltimore
country: United States
facility: Sinai Hospital Of Baltimore
state: Maryland
city: Boston
country: United States
facility: Dana-Farber Cancer Institute
state: Massachusetts
city: Ann Arbor
country: United States
facility: University of Michigan
state: Michigan
city: Detroit
country: United States
facility: Henry Ford Hospital
state: Michigan
city: Minneapolis
country: United States
facility: Minnesota Oncology Hematology, P.A.
state: Minnesota
city: Hattiesburg
country: United States
facility: Hattiesburg Clinic Hematology/Oncology
state: Mississippi
city: Jackson
country: United States
facility: Local Institution - 0242
state: Mississippi
city: East Brunswick
country: United States
facility: Astera Cancer Care
state: New Jersey
city: Ridgewood
country: United States
facility: Local Institution - 0363
state: New Jersey
city: Albuquerque
country: United States
facility: University of New Mexico Comprehensive Cancer Center
state: New Mexico
city: Bronx
country: United States
facility: New York Cancer and Blood Specialists
state: New York
city: Buffalo
country: United States
facility: Local Institution - 0245
state: New York
city: Lake Success
country: United States
facility: Northwell Health/ RJ Zuckerberg Cancer Center
state: New York
city: New Hyde Park
country: United States
facility: New York Cancer and Blood Specialists
state: New York
city: New York
country: United States
facility: New York Cancer and Blood Specialists
state: New York
city: Rochester
country: United States
facility: Rochester General Hospital
state: New York
city: Shirley
country: United States
facility: New York Cancer and Blood Specialists
state: New York
city: Williamsville
country: United States
facility: Local Institution - 0274
state: New York
city: Durham
country: United States
facility: Duke Cancer Institute
state: North Carolina
city: Cincinnati
country: United States
facility: Oncology Hematology Care
state: Ohio
city: Cleveland
country: United States
facility: Fairview Hospital
state: Ohio
city: Cleveland
country: United States
facility: Cleveland Clinic
state: Ohio
city: Mayfield Heights
country: United States
facility: Cleveland Clinic - Hillcrest Hospital
state: Ohio
city: Allentown
country: United States
facility: Lehigh Valley Health Network
state: Pennsylvania
city: York
country: United States
facility: Local Institution - 0264
state: Pennsylvania
city: Germantown
country: United States
facility: The West Clinic, PLLC dba West Cancer Center
state: Tennessee
city: Abilene
country: United States
facility: Texas Oncology - West Texas
state: Texas
city: Houston
country: United States
facility: University of Texas MD Anderson Cancer Center
state: Texas
city: San Antonio
country: United States
facility: Mays Cancer Center
state: Texas
city: San Antonio
country: United States
facility: Texas Oncology - San Antonio
state: Texas
city: Salt Lake City
country: United States
facility: Utah Cancer Specialists
state: Utah
city: Fredericksburg
country: United States
facility: Hematology Oncology Associates of Fredericksburg
state: Virginia
city: Norfolk
country: United States
facility: Virginia Oncology Associates
state: Virginia
city: Roanoke
country: United States
facility: Blue Ridge Cancer Care
state: Virginia
city: Seattle
country: United States
facility: VA Puget Sound Health Care System
state: Washington
city: Seattle
country: United States
facility: Local Institution - 0293
state: Washington
city: Spokane
country: United States
facility: Local Institution - 0097
state: Washington
city: Vancouver
country: United States
facility: Northwest Cancer Specialists, P.C.
state: Washington
city: Madison
country: United States
facility: Local Institution - 0220
state: Wisconsin
city: Chivilcoy
country: Argentina
facility: Sanatorio Chivilcoy
state: Buenos Aires
city: Cordoba
country: Argentina
facility: Hospital Privado Universitario de Córdoba
state: Córdoba
city: Viedma
country: Argentina
facility: Clinica Viedma S. A
state: R
city: Rosario
country: Argentina
facility: Hospital Privado de Rosario
state: Santa FE
city: Buenos Aires
country: Argentina
facility: Centro Mdico "Barrio Parque"
city: Buenos Aires
country: Argentina
facility: Hospital Británico de Buenos Aires
city: Santa Fe
country: Argentina
facility: Clínica de Nefrología, Urología y Enfermedades Cardiovasculares
city: Liverpool
country: Australia
facility: Liverpool Hospital
state: New South Wales
city: Waratah
country: Australia
facility: Calvary Mater Newcastle
state: New South Wales
city: Wollongong
country: Australia
facility: Wollongong Hospital-Illawarra Cancer Care Centre
state: New South Wales
city: Birtinya
country: Australia
facility: Sunshine Coast University Hospital
state: Queensland
city: Box Hill
country: Australia
facility: Box Hill Hospital
state: Victoria
city: Melbourne
country: Australia
facility: The Alfred Hospital
state: Victoria
city: Melbourne
country: Australia
facility: St Vincent's Hospital
state: Victoria
city: Nedlands
country: Australia
facility: Sir Charles Gairdner Hospital
state: Western Australia
city: Vienna
country: Austria
facility: Klinik Ottakring
state: Wien
city: Krems an der Donau
country: Austria
facility: Universitätsklinikum Krems
city: Leoben
country: Austria
facility: LKH Hochsteiermark - Standort Leoben
city: St. Pölten
country: Austria
facility: Universitätsklinikum St. Pölten
city: Wien
country: Austria
facility: Hanusch-Krankenhaus
city: Genk
country: Belgium
facility: Ziekenhuis Oost-Limburg, Campus St.-Jan
state: Limburg
city: Gent
country: Belgium
facility: UZ Gent
state: Oost-Vlaanderen
city: Sint-Niklaas
country: Belgium
facility: AZ Nikolaas
state: Oost-Vlaanderen
city: Antwerpen
country: Belgium
facility: ZNA Cadix
city: Salvador
country: Brazil
facility: Instituto D'Or de Pesquisa e Ensino (IDOR) - Filial Salvador
state: Bahia
city: Porto Alegre
country: Brazil
facility: Centro Gaucho Integrado De Oncologia, Hematologia, Ensino E Pesquisa
state: Rio Grande Do Sul
city: Joinville
country: Brazil
facility: Instituto Joinvilense de Hematologia e Oncologia
state: Santa Catarina
city: Jau
country: Brazil
facility: Hospital Amaral Carvalho
state: São Paulo
city: Rio de Janeiro
country: Brazil
facility: Americas Centro de Oncologia Integrado
city: Sao Paulo
country: Brazil
facility: Clínica Médica São Germano S/S Ltda
city: Sao Paulo
country: Brazil
facility: Sociedade Beneficente Israelita Brasileira Hospital Albert Einstein
city: Greenfield Park
country: Canada
facility: Centre Intégré de Santé et de Services Sociaux de la Montérégie-Centre
state: Quebec
city: Montreal
country: Canada
facility: Centre intégré universitaire de santé et de services sociaux du Nord-de-l'Île-de-Montréal (CIUSSS NÎM) - Hôpital du Sacré-Coeur
state: Quebec
city: Quebec City
country: Canada
facility: Centre intégré de cancérologie du CHU de Québec Université Laval, Hôpital de l'Enfant-Jésus
state: Quebec
city: Santiago
country: Chile
facility: Clínica Inmunocel
state: Región Metropolitana De Santiago
city: Santiago
country: Chile
facility: Bradfordhill
state: Región Metropolitana De Santiago
city: Viña del Mar
country: Chile
facility: Centro de Investigaciones
state: Valparaíso
city: Beijing City
country: China
facility: Beijing Chaoyang Hospital, Capital Medical University
state: Beijing
city: Beijing City
country: China
facility: Local Institution - 0165
state: Beijing
city: Beijing
country: China
facility: Local Institution - 0141
state: Beijing
city: Chongqing
country: China
facility: The First Afffiliated Hospital of Chongqing Medical University
state: Chongqing
city: Xiamen
country: China
facility: The First Affiliated hospital of Xiamen University
state: Fujian
city: Guangzhou
country: China
facility: Henan Cancer Hospital
state: Guangdong
city: Guangzhou
country: China
facility: Sun Yat-sen University Cancer Center
state: Guangdong
city: Guangzhou
country: China
facility: Local Institution - 0168
state: Guangdong
city: Shenzhen
country: China
facility: Shenzhen Second People's Hospital
state: Guangdong
city: Liuzhou
country: China
facility: Local Institution - 0412
state: Guangxi
city: Nanning
country: China
facility: Guangxi Medical University No.1 Affiliated Hospital
state: Guangxi
city: Shijiazhuang
country: China
facility: The First Hospital of Hebei Medical University
state: Hebei
city: Luoyang
country: China
facility: Local Institution - 0395
state: Henan
city: Zhengzhou
country: China
facility: People's Hospital of Henan Province
state: Henan
city: Wuhan
country: China
facility: Wuhan Union Hospital
state: Hubei
city: Changsha
country: China
facility: Xiangya Hospital Central South University
state: Hunan
city: Changsha
country: China
facility: The Third Xiangya Hospital of Central South University
state: Hunan
city: Nanjing
country: China
facility: Nanjing Drum Tower Hospital The Affiliated Hospital of Nanjing University Medical School
state: Jiangsu
city: Wuxi
country: China
facility: Wuxi People's Hospital
state: Jiangsu
city: Shenyang
country: China
facility: Shengjing Hospital of China Medical University
state: Liaoning
city: Xi'An
country: China
facility: The Second Affiliated Hospital of Xi'an Jiaotong University
state: Shaanxi
city: Xi'an
country: China
facility: Local Institution - 0110
state: Shaanxi
city: Qingdao
country: China
facility: The Affiliated Hospital of Qingdao University
state: Shandong
city: Shanghai
country: China
facility: Shanghai 6th people's hospital
state: Shanghai
city: Shanghai
country: China
facility: Tongji University - Shanghai Fourth People's Hospital
state: Shanghai
city: Taiyuan
country: China
facility: First Affiliated Hospital of Shanxi Medical University
state: Shanxi
city: Deyang
country: China
facility: Local Institution - 0356
state: Sichuan
city: Tianjin
country: China
facility: Tianjin Medical University Cancer Institute and Hospital
state: Tianjin
city: Urumqi
country: China
facility: Local Institution - 0353
state: Xinjiang
city: Kunming
country: China
facility: First Affiliated Hospital of Kunming Medical University
state: Yunnan
city: Hangzhou
country: China
facility: Local Institution - 0151
state: Zhejiang
city: Linhai
country: China
facility: Taizhou Hospital of Zhejiang Province
state: Zhejiang
city: Ningbo
country: China
facility: Ningbo First Hospital
state: Zhejiang
city: Wenzhou
country: China
facility: The First Affiliated Hospital of Wenzhou Medical University
state: Zhejiang
city: Beijing
country: China
facility: Peking University First Hospital
city: Taiyuan
country: China
facility: Shanxi Bethune Hospital
city: Brno
country: Czechia
facility: Fakultní nemocnice Brno Bohunice
state: Brno-město
city: PRague
country: Czechia
facility: Fakultni nemocnice Kralovske Vinohrady
state: Praha 10
city: Praha
country: Czechia
facility: Vseobecna fakultni nemocnice v Praze
city: Kuopio
country: Finland
facility: Kuopion Yliopistollinen Sairaala
state: Pohjois-Savo
city: Helsinki
country: Finland
facility: Helsinki University Hospital - Comprehensive Cancer Center (HYKS - Syöpäkeskus)
city: Strasbourg
country: France
facility: Institut de cancérologie Strasbourg Europe (ICANS)
state: Alsace
city: Pessac
country: France
facility: CHU Bordeaux Haut-Leveque
state: Aquitaine
city: Lille
country: France
facility: Hopital Claude Huriez - CHU de Lille
state: Nord
city: Lyon Cedex08
country: France
facility: Centre Leon Berard
state: Rhône-Alpes
city: Clermont-Ferrand
country: France
facility: Centre Hospitalier Universitaire Estaing
city: Limoges
country: France
facility: Centre Hospitalier Universitaire de Limoges - Hôpital Dupuytren
city: Nantes
country: France
facility: Centre Hospitalier Universitaire de Nantes - L' Hopital l'hôtel-Dieu
city: Nîmes
country: France
facility: Centre Hospitalier Universitaire de Nîmes - Institut de Cancérologie du Gard - Hôpital Universitaire Carémeau
city: Tours
country: France
facility: Centre Hospitalier Régional Universitaire de Tours - Hôpital Bretonneau
city: Paris
country: France
facility: Hôpital Saint Antoine
state: Île-de-France
city: München
country: Germany
facility: TUM Universitätsklinikum, Technische Universität München
state: Bayern
city: Traunstein
country: Germany
facility: Klinikum Traunstein
state: Bayern
city: Weiden
country: Germany
facility: Medizinisches Versorgungszentrum
state: Bayern
city: Marburg
country: Germany
facility: Universitätsklinikum Marburg
state: Hessen
city: Hannover
country: Germany
facility: Local Institution - 0414
state: Niedersachsen
city: Bonn
country: Germany
facility: Universitätsklinikum Bonn
state: Nordrhein-Westfalen
city: Düsseldorf
country: Germany
facility: Local Institution - 0415
state: Nordrhein-Westfalen
city: Kiel
country: Germany
facility: Universitaetsklinikum Schleswig-Holstein Campus Kiel
state: Schleswig-Holstein
city: Erfurt
country: Germany
facility: Local Institution - 0396
state: Thüringen
city: Aachen
country: Germany
facility: Universitätsklinikum Aachen
city: Bamberg
country: Germany
facility: Sozialstiftung Bamberg
city: Dresden
country: Germany
facility: Local Institution - 0413
city: Hamburg
country: Germany
facility: Universitaetsklinikum Hamburg-Eppendorf
city: Hamburg
country: Germany
facility: Asklepios Altona
city: Tuebingen
country: Germany
facility: Universitaetsklinikum Tuebingen
city: Würzburg
country: Germany
facility: Gemeinschaftspraxis Dres. med. Björn Schöttker & Dominik Pretscher
city: Athens
country: Greece
facility: Evangelismos General Hospital of Athens
state: Attikí
city: Athens
country: Greece
facility: Alexandra General Hospital of Athens
state: Attikí
city: Thessaloniki
country: Greece
facility: G. Papanikolaou General Hospital
state: Thessaloníki
city: Ahmedabad
country: India
facility: HCG Aastha Cancer Centre
state: Gujarat
city: Gurugram
country: India
facility: Marengo Asia Hospitals Gurugram
state: Haryana
city: Belagavi
country: India
facility: KLES Dr. Prabhakar Kore Hospital & M.R.C
state: Karnataka
city: Madurai
country: India
facility: Meenakshi Mission Hospital and Research Centre
state: Tamil Nadu
city: Varanasi
country: India
facility: Local Institution - 0341
state: Uttar Pradesh
city: Ludhiana
country: India
facility: Christian Medical College & Hospital
city: Puducherry
country: India
facility: Jawaharlal Institute Of Postgraduate Medical Education And Research
city: Galway
country: Ireland
facility: University College Hospital - Galway
state: Connaught
city: Cork
country: Ireland
facility: Cork University Hospital
city: Dublin
country: Ireland
facility: St. James's Hospital
city: Limerick
country: Ireland
facility: Local Institution - 0251
city: Kfar Saba
country: Israel
facility: Meir Medical Center
state: HaMerkaz
city: Ramat Gan
country: Israel
facility: Sheba Medical Center
state: HaMerkaz
city: Haifa
country: Israel
facility: Rambam Health Care Campus
state: HaTsafon
city: Tel Aviv
country: Israel
facility: Sourasky Medical Center
state: Tall Abīb
city: Jerusalem
country: Israel
facility: Hadassah Medical Center - Do Not Use - Duplicate Facility
state: Yerushalayim
city: Peatch Tikva
country: Israel
facility: Rabin Medical Center
city: Meldola
country: Italy
facility: IRCCS - Istituto Romagnolo per lo Studio dei Tumori (IRST) "Dino Amadori"
state: Emilia-Romagna
city: Catania
country: Italy
facility: Policlinico "G. Rodolico"
state: Sicilia
city: Bologna
country: Italy
facility: IRCCS Azienda Ospedaliero-Universitaria di Bologna, Policlinico di Sant'Orsola
city: Pavia
country: Italy
facility: Fondazione IRCCS Policlinico San Matteo
city: Roma
country: Italy
facility: Azienda Ospedaliera Sant'Andrea
city: Kashiwa
country: Japan
facility: National Cancer Center Hospital East
state: Chiba
city: Kitakyushu-shi
country: Japan
facility: Japan Community Healthcare Organization Kyushu Hospital
state: Fukuoka
city: Sapporo
country: Japan
facility: National Hospital Organization Hokkaido Cancer Center
state: Hokkaido
city: Shiwa-gun Yahaba-cho
country: Japan
facility: Iwate Medical University Hospital
state: Iwate
city: Kamakura
country: Japan
facility: Shonan Kamakura General Hospital
state: Kanagawa
city: Iruma
country: Japan
facility: Saitama Medical University Hospital
state: Saitama
city: Koshigaya
country: Japan
facility: Dokkyo Medical University Saitama Medical Center
state: Saitama
city: Nagaizumi-cho,Sunto-gun
country: Japan
facility: Shizuoka Cancer Center
state: Shizuoka
city: Itabashiku
country: Japan
facility: Nihon University Itabashi Hospital
state: Tokyo
city: Chiba
country: Japan
facility: Chiba University Hospital
city: Fukuoka
country: Japan
facility: National Hospital Organization Kyushu Medical Center
city: Fukuoka
country: Japan
facility: Japanese Red Cross Fukuoka Hospital
city: Hiroshima
country: Japan
facility: Hiroshima Red Cross Hospital & Atomic-bomb Survivors Hospital
city: Kumamoto
country: Japan
facility: Kumamoto University
city: Nagasaki
country: Japan
facility: The Japanese Red Cross Nagasaki Genbaku Hospital
city: Tokyo
country: Japan
facility: The Jikei University Hospital
city: Tokyo
country: Japan
facility: Japanese Red Cross Medical Center
city: Busan
country: Korea, Republic of
facility: Local Institution - 0106
state: Busan-gwangyeoksi
city: Busan
country: Korea, Republic of
facility: Pusan National University Hospital
state: Busan-gwangyeoksi
city: Seongnam
country: Korea, Republic of
facility: Local Institution - 0102
state: Gyeonggido
city: Seongnam
country: Korea, Republic of
facility: Seoul National University Bundang Hospital
state: Gyeonggido
city: Hwasun
country: Korea, Republic of
facility: Chonnam National University Hwasun Hospital
state: Jeonranamdo
city: Hwasun
country: Korea, Republic of
facility: Local Institution - 0103
state: Jeonranamdo
city: Seoul
country: Korea, Republic of
facility: Local Institution - 0101
state: Seoul Teugbyeolsi
city: Seoul
country: Korea, Republic of
facility: Seoul National University Hospital
state: Seoul Teugbyeolsi
city: Seoul
country: Korea, Republic of
facility: Samsung Medical Center
state: Seoul Teugbyeolsi
city: Seoul
country: Korea, Republic of
facility: Local Institution - 0104
state: Seoul Teugbyeolsi
city: Seoul
country: Korea, Republic of
facility: The Catholic Univ. of Korea Seoul St. Mary's Hospital
state: Seoul Teugbyeolsi
city: Seoul
country: Korea, Republic of
facility: Asan Medical Center
state: Seoul-teukbyeolsi [Seoul]
city: Seoul
country: Korea, Republic of
facility: Local Institution - 0105
state: Seoul-teukbyeolsi
city: Seoul
country: Korea, Republic of
facility: Local Institution - 0100
city: Seoul
country: Korea, Republic of
facility: Severance Hospital, Yonsei University Health System
city: Seoul
country: Korea, Republic of
facility: Local Institution
city: Tauranga
country: New Zealand
facility: Tauranga Hospital
state: Bay Of Plenty
city: Dunedin
country: New Zealand
facility: Dunedin Hospital
state: Otago
city: Auckland
country: New Zealand
facility: Auckland City Hospital
city: Auckland
country: New Zealand
facility: Local Institution - 0334
city: Torun
country: Poland
facility: MICS Centrum Medyczne Torun
state: Kujawsko-pomorskie
city: Warsaw
country: Poland
facility: Instytut Hematologii i Transfuzjologii
state: Mazowieckie
city: Kraków
country: Poland
facility: Local Institution - 0325
state: Małopolskie
city: Słupsk
country: Poland
facility: Local Institution - 0292
state: Pomorskie
city: Skórzewo
country: Poland
facility: Local Institution - 0346
state: Wielkopolskie
city: Katowice
country: Poland
facility: Pratia Onkologia Katowice
city: Braga
country: Portugal
facility: Hospital de Braga
city: Lisbon
country: Portugal
facility: Champalimaud Foundation
city: Porto
country: Portugal
facility: Instituto Português de Oncologia do Porto Francisco Gentil, EPE
city: San Juan
country: Puerto Rico
facility: Local Institution - 0355
city: Bucharest
country: Romania
facility: Fundeni Clinical Institute
city: Cluj Napoca
country: Romania
facility: Institutul Oncologic Cluj
city: Iasi
country: Romania
facility: Institutul Regional de Oncologie Iasi
city: Centurion
country: South Africa
facility: Local Institution - 0405
state: GP
city: Cape Town
country: South Africa
facility: Local Institution - 0404
state: Western Cape
city: Kuilsriver
country: South Africa
facility: Local Institution - 0407
state: Western Cape
city: Plumstead
country: South Africa
facility: Local Institution - 0406
state: Western Cape
city: Palma
country: Spain
facility: Hospital Universitari Son Espases
state: Balears [Baleares]
city: Barcelona
country: Spain
facility: Hospital Clínic de Barcelona
state: Catalunya [Cataluña]
city: Barcelona
country: Spain
facility: Local Institution - 0073
state: Catalunya [Cataluña]
city: Palma
country: Spain
facility: Local Institution - 0183
state: Illes Balears
city: Murcia
country: Spain
facility: Hospital General Universitario Morales Meseguer
state: Murcia, Región De
city: Marbella
country: Spain
facility: Hospital Costa del Sol
state: Málaga
city: Marbella
country: Spain
facility: Local Institution - 0182
state: Málaga
city: Cáceres
country: Spain
facility: Hospital San Pedro de Alcantara
city: León
country: Spain
facility: Complejo Asistencial Universitario de León - Hospital de León
city: Madrid
country: Spain
facility: Hospital Universitario 12 de Octubre
city: Ankara
country: Turkey
facility: Ankara University Health Practice and Research Hospitals
city: Ankara
country: Turkey
facility: Liv Hospital Ankara
city: Istanbul
country: Turkey
facility: Istanbul University, Istanbul Faculty of Medicine
city: İzmir
country: Turkey
facility: Ege Universitesi Hastanesi
city: Kayseri
country: Turkey
facility: Erciyes Universitesi Tıp Fakultesi Hastaneleri
city: Samsun
country: Turkey
facility: Ondokuz Mayıs Universitesi
city: Cambridge
country: United Kingdom
facility: Addenbrooke's Hospital
state: Cambridgeshire
city: Truro
country: United Kingdom
facility: The Royal Cornwall Hospital
state: England
city: Airdrie
country: United Kingdom
facility: Lanarkshire NHS Trust - Monklands Hospital
state: Great Britain
city: London
country: United Kingdom
facility: King's College Hospital
state: Greater London
city: Leicester
country: United Kingdom
facility: Leicester Royal Infirmary
state: Leicestershire
city: London
country: United Kingdom
facility: Hammersmith Hospital
state: London, City Of
city: Barnet
country: United Kingdom
facility: Barnet Hospital
city: Newcastle upon Tyne
country: United Kingdom
facility: Freeman Hospital
city: Stoke-on-Trent
country: United Kingdom
facility: Royal Stoke University Hospital
Study officials:
affiliation: Bristol-Myers Squibb
name: Bristol-Myers Squibb
role: STUDY_DIRECTOR
References: