Clinical trial NCT04819165: Healthcare-associated Infections in Severe COVID-19 During 2020
Official title: Healthcare-associated Infections in Severe COVID-19 Patients Whit Mechanical Ventilation During 2020
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Respiration, Artificial
COVID-19
Health Care Associated Infection
Lead sponsor: Sanatorio Anchorena San Martin
Sponsor class: OTHER
First posted: 2021-03-26
Enrollment: 252
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: RETROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Patients admitted to ICU who required invasive mechanical ventilation during the COVID-19 pandemic from March to December 2020.

Brief summary: In patients who develop ARDS due to SARS-CoV-2 (CARDS), a longer duration of invasive mechanical ventilation (IMV) and ICU stay has been reported compared to ARDS not associated with SARS-CoV-2. Consequently, the days of stay in ICU increase Identifying the risk factors associated with the development of this complication and developing measures aimed at its prevention could have a favorable impact on the clinical course of seriously ill patients.

Detailed description: The rate of catheter-associated bacteremia is 3.78 / 1000 days central venous catheters in polyvalent ICUs.

Some studies suggest that in the context of this pandemic, infections associated with health care have increased, although there are few data referring to Latin America.

The objective of this study is to analyze the incidence of health care associated infections in adult patients on invasive mechanical ventilation with confirmed COVID-19 diagnosis and negative COVID-19 admitted to the Intensive Care Unit of the Anchorena San Martín Clinic, San Martín, Buenos Aires.

Eligibility criteria: Inclusion Criteria:

* All patients older than 18 years admitted to the intensive care unit of the Anchorena San Martín Clinic who required invasive mechanical ventilation for more than 24 hours in a period between March 2020 and December 2020 were included in the analysis.

Exclusion Criteria:

* All patients who presented incomplete data in the follow-up sheets were excluded.

Primary outcomes:
measure: Incidence of health care associated infections in each group.
timeFrame: March to December 2020
Secondary outcomes:
measure: The most frequent pathogens in this population associated with Incidence of health care associated infections.
timeFrame: March to December 2020
measure: Possible factors associated with Incidence of health care associated infections.
timeFrame: March to December 2020
measure: mortality in UCI
timeFrame: March to December 2020
measure: Days of ICU stay
timeFrame: March to December 2020
measure: Days of mechanical ventilation
timeFrame: March to December 2020
Other outcomes:
Locations:
city: San Martín
country: Argentina
facility: Sanatorio Anchorena de San Martin
state: Buenos Aires
Study officials:
affiliation: SAnchorena San Martin
name: matias accoce
role: PRINCIPAL_INVESTIGATOR
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