Clinical trial NCT06171841: Effects of Low-Intensity Blood Flow Restriction Training in Normoxia and Hypoxia Conditions
Official title: Acute and Chronic Effects of Low-Intensity Blood Flow Restriction Training in Normoxia and Hypoxia Conditions on Muscle Strength, Thickness, Catecholamine, and Inflammatory Responses in Physically Active Adults
Study type: INTERVENTIONAL
Overall status: ACTIVE_NOT_RECRUITING
Phase: NA
Conditions: Hypoxia, Altitude
Blood Flow Restriction
Resistance Training
Lead sponsor: The Jerzy Kukuczka Academy of Physical Education in Katowice
Sponsor class: OTHER
First posted: 2023-12-15
Enrollment: 60
Sex: ALL
Minimum age (years): 18
Maximum age (years): 30
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: One approach to significantly reducing resistance training intensity while maintaining effectiveness in muscle mass and strength development involves conducting training sessions under hypoxic conditions. This is likely due to heightened physiological responses. While sports science research indicates a substantial impact of hypoxic conditions on immediate increases in metabolic stress and augmented hormonal responses, recent findings suggest that the role of their influence on skeletal muscle adaptations post-resistance training under hypoxic conditions remains unknown. Additionally, there is a lack of reports on whether the type of hypoxia applied via blood flow restriction or chamber differentiates the increase in secretion of these catecholamines in both immediate and long-term aspects.


Eligibility criteria: Inclusion Criteria:

* Regularly physically active (at least 30 mins of structured exercise 3 times per week),
* Sea-level natives,
* Experienced in resistance training (at least one year of experience in regular resistance exercise)

Exclusion Criteria:

* presence of any medical risk factors to exercise and/or exposure to altitude
* presence of any medical condition that would make the protocol unreasonably hazardous for the participant
* smokers

Primary outcomes:
measure: Force Output
timeFrame: Immediately pre and post first and last training session
measure: One-Repetition Maximum
timeFrame: within 5 days from the start and end of training
measure: Maximum Number of Repetitions
timeFrame: within 5 days from the start and end of training
measure: Countermovement Jump Height
timeFrame: Immediately pre and post first and last training session
measure: Countermovement Jump Power Output
timeFrame: Immediately pre and post first and last training session
measure: Catecholamine Response
timeFrame: Immediately pre and post first and last training session
measure: Muscle Stiffness
timeFrame: Immediately pre and post first and last training session
measure: Muscle Thickness
timeFrame: within 5 days from the start and end of training
Secondary outcomes:
measure: Perception of Pain
timeFrame: Immediately pre and post every training session
measure: Perception of Effort
timeFrame: Immediately pre and post every training session
measure: Blood Pressure
timeFrame: Immediately pre and post first and last training session
Other outcomes:
measure: Total Body Mass
timeFrame: within 5 days from the start and end of training
measure: Percentage Body Fat
timeFrame: within 5 days from the start and end of training
measure: Bone Mass Density
timeFrame: within 5 days from the start and end of training
measure: Bone Mineral Content
timeFrame: within 5 days from the start and end of training
Locations:
city: Katowice
country: Poland
facility: The Jerzy Kukuczka Academy of Physical Education
state: Śląsk
Study officials:
References: