Clinical trial NCT05396716: Acupoint Stimulation Alleviates Postoperative Nausea and Vomiting
Official title: Effect of Transcutaneous Electrical Acupoint Stimulation on Postoperative Nausea and Vomiting After Liver Surgery
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: PONV
Keywords: transcutaneous electrical acupoint stimulation
liver surgery
Lead sponsor: Air Force Military Medical University, China
Sponsor class: OTHER
First posted: 2022-05-31
Enrollment: 158
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: PREVENTION

Brief summary: Incidence of postoperative nausea and vomiting (PONV) could be high as 60% after liver surgery. Acupoint stimulation has been proved to decrease PONV. In this study, we will investigate the effect of transcutaneous electrical acupoint stimulation on incidence of PONV after liver surgery.


Eligibility criteria: Inclusion Criteria:

* age ≥18 years
* scheduled for elective liver surgery under general anesthesia

Exclusion Criteria:

* body mass index less than 18 kg/m2 or higher than 30 kg/m2
* American Society of Anesthesiologists status higher than Ⅲ
* patients with contraindication to transcutaneous electrical stimulation, including skin damage, infection or implantable electrical device
* suspected or existed abuse of drug or alcohol
* pregnant or breeding women
* history of neurological or psychiatric disease

Primary outcomes:
measure: incidence of nausea and vomiting by 24 hours after surgery
timeFrame: from end of surgery to 24 hours after surgery, in a total of 24 hours
Secondary outcomes:
measure: incidence of nausea and vomiting by 48 hours after surgery
timeFrame: from end of surgery to 48 hours after surgery, in a total of 48 hours
measure: incidence of nausea and vomiting in PACU (post-anesthesia care unit)
timeFrame: from end of surgery to discharge from PACU(post-anesthesia care unit), in an average of 30 minutes
measure: score of nausea and vomiting by 24 hours after surgery
timeFrame: from end of surgery to 24 hours after surgery, in a total of 24 hours
measure: score of nausea and vomiting by 48 hours after surgery
timeFrame: from end of surgery to 48 hours after surgery, in a total of 48 hours
measure: score of nausea and vomiting in PACU(post-anesthesia care unit)
timeFrame: from end of surgery to discharge from PACU, in an average of 30 minutes
measure: Quality of recovery score at 24 hours after surgery
timeFrame: from end of surgery to 24 hours after surgery, in a total of 24 hours
measure: Quality of recovery score at 48 hours after surgery
timeFrame: from end of surgery to 48 hours after surgery, in a total of 48 hours
measure: postoperative in-hospital stay
timeFrame: from end of surgery to discharge from hospital, in an average of 7 days
measure: death by 6 months after surgery
timeFrame: from end of surgery to 6 months after surgery, in a total of 6 months
Other outcomes:
Locations:
Study officials:
References:
citation: Lee A, Chan SK, Fan LT. Stimulation of the wrist acupuncture point PC6 for preventing postoperative nausea and vomiting. Cochrane Database Syst Rev. 2015 Nov 2;2015(11):CD003281. doi: 10.1002/14651858.CD003281.pub4.