Clinical trial NCT05725486: N-3 Polyunsaturated Fatty Acids Enriched Chicken Meet and Cardiovascular Function
Official title: Effects of N-3 Polyunsaturated Fatty Acids Enriched Chicken Meet on Cardiovascular Function
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: n-3 Polyunsaturated Fatty Acids
Keywords: n-3 polyunsaturated fatty acids
vascular function
endothelium
oxidative stress
inflammation
microcircularion
macrocirculation
Lead sponsor: Josip Juraj Strossmayer University of Osijek
Sponsor class: OTHER
First posted: 2023-02-13
Enrollment: 50
Sex: ALL
Minimum age (years): 18
Maximum age (years): 39
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: PREVENTION

Brief summary: Evidence from multiple experimental, epidemiological, and clinical studies indicate that n-3 polyunsaturated fatty acids (n-3 PUFAs) may exert their cardiovascular (CV) protective effect, at least in part, by improving vascular endothelium-dependent function. Previously, the investigators demonstrated the significant beneficiary effect of consumption of n-3 PUFA-enriched hen eggs on microvascular endothelium-dependent reactivity, even in young healthy individuals.

The hypothesis of this research is that the consumption of n-3 PUFAs in the form of functionally enriched chicken meet has a beneficial effect on vascular reactivity measured in different vascular beds, and the lipid profile with a positive effect on the reduction of oxidative stress and inflammatory response in healthy sedentary individuals.

The main goal of this study is to investigate the influence of n-3 PUFAs functionally enriched chicken meet on vascular and endothelial function in a population of healthy young subjects and active athletes.


Eligibility criteria: Inclusion Criteria:

* young healthy sedentary individuals - did not perform regular physical activities for at least 12 months before conducting the study
* young healthy active athletes - have a minimum of 5 training sessions per week (mainly endurance training) for at least 12 months prior to conducting the study

Exclusion Criteria:

* smoking
* hypertension
* coronary disease
* diabetes
* hyperlipidemia
* kidney damage
* cerebrovascular and peripheral artery diseases
* and any other disease that could have an impact on vascular and endothelial function

Primary outcomes:
measure: Microvascular endothelial function
timeFrame: 3 weeks
measure: Macrovascular endothelial function
timeFrame: 3 weeks
measure: Cerebrovascular reactivity
timeFrame: 3 weeks
Secondary outcomes:
measure: Lipid profile
timeFrame: 3 weeks
measure: Oxidative stress status
timeFrame: 3 weeks
measure: Systemic hemodynamics
timeFrame: 3 weeks
measure: Serum Pro- and Anti-Inflammatory Cytokines, Chemokines, Growth Factors and Soluble Cell Adhesion Molecules Protein Concentration
timeFrame: 3 weeks
measure: Body composition
timeFrame: 3 weeks
measure: Body fluid status
timeFrame: 3 weeks
measure: Oxidative stress status
timeFrame: 3 weeks
measure: Oxidative stress status
timeFrame: 3 weeks
Other outcomes:
Locations:
city: Osijek
country: Croatia
facility: Scientific Center of Excellence for Personalized Health Care, Josip Juraj Strossayer University of Osijek
Study officials:
References: