Clinical trial NCT00159419: Bisphosphonate Therapy for Osteogenesis Imperfecta
Official title: Bisphosphonate Therapy for Osteogenesis Imperfecta
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE4
Conditions: Osteogenesis Imperfecta
Osteoporosis
Paget Disease of Bone
Keywords: Osteogenesis Imperfecta
Fractures
Pediatric
Osteoporosis
Juvenile Pagets
Lead sponsor: Indiana University
Sponsor class: OTHER
First posted: 2005-09-12
Enrollment: 18
Sex: ALL
Minimum age (years): 3
Maximum age (years): 21
Standard ages: CHILD
ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The study is designed to evaluate the efficacy and safety of "Bisphosphonate Therapy for Osteogenesis Imperfecta (OI)." We, the researchers at Indiana University School of Medicine, are characterizing the changes effected by oral bisphosphonate therapy and comparing them to a regimen of intravenous bisphosphonate therapy in a group of children with OI and also in children with other disorders that result in low bone mass and fractures.

Detailed description: The study is designed to evaluate the efficacy and safety of "Bisphosphonate Therapy for Osteogenesis Imperfecta (OI)." OI is an inherited disorder of collagen synthesis. Collagen is the major structural protein of the matrix of tendons, skin, and bones. Affected persons have low bone mineral density (and experience multiple fractures and progressive bony deformity). In its most severe form, the disorder is lethal in infancy. We plan to characterize the changes effected by oral bisphosphonate therapy and compare them to a regimen of intravenous bisphosphonate therapy in a group of children with OI.

Additionally, we have begun to treat patients with OI and other conditions of low bone mineralization for age who are not eligible for the standard protocol (too young, history of abdominal pain, etc.) with bisphosphonate. We also plan to screen the parents and siblings of our patients diagnosed with osteogenesis imperfecta, in order to determine if they also have osteoporosis.

Eligibility criteria: Inclusion Criteria:

* Diagnosis of OI, as defined by genetic analysis revealing a defect of type I collagen, OR by bone mineral density (BMD) \<2.5 standard deviations (SD) for age plus two of the following:

  * Family history of OI
  * Frequent fractures
  * Blue sclerae
  * Multiple wormian bones on skull x-ray
  * Hearing disturbance
  * Dentinogenesis imperfecta
* Age between 3 and 21 years at the start of the study period.
* Children must be able to swallow whole tablets
* Parents of children must be able to understand protocol and give informed consent.

Exclusion Criteria:

* Therapy with bisphosphonates during the past 12 months.
* Other "non-traditional" therapy for OI in the last 6 months, such as growth hormone or anabolic steroids.
* Other chronic diseases besides OI that interfere with bone morphology or gastrointestinal absorption

Primary outcomes:
measure: Bone Mineral Density
timeFrame: 2 years
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
affiliation: Indiana University School of Medicine
name: Linda A DiMeglio, MD, MPH
role: PRINCIPAL_INVESTIGATOR
References: