Clinical trial NCT04062500: Registry for Longitudinal Mortality and Therapy in Patients With Heart Failure
Official title: Registry for Longitudinal Mortality and Therapy in Patients With Heart Failure (GREARTWAL Study)
Study type: OBSERVATIONAL
Overall status: RECRUITING
Conditions: Heart Failure
Keywords: Heart Failure,prognostic, registry
Lead sponsor: Shanghai 10th People's Hospital
Sponsor class: OTHER
Collaborators: name: First Affiliated Hospital, Sun Yat-Sen University
name: Nanfang Hospital, Southern Medical University
name: Beijing Chao Yang Hospital
name: First Hospital of China Medical University
name: Yangpu District Central Hospital Affiliated to Tongji University
name: Xuhui Central Hospital, Shanghai
name: Ningbo Medical Center Lihuili Hospital
name: Shaanxi University of Chinese Medicine
name: People's Hospital of Xinjiang Uygur Autonomous Region
name: The First Affiliated Hospital of Zhengzhou University
First posted: 2019-08-20
Enrollment: 10500
Sex: ALL
Minimum age (years): 18
Maximum age (years): 90
Standard ages: ADULT
OLDER_ADULT
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: Patients with heart failure

Brief summary: The purpose of this registry is to compile a large clinical database on the medical management of patients hospitalized with acute heart failure, using information collected from hospitals across China.

Detailed description: Registry for Longitudinal mortality and therapy in patients with Heart Failure is a large, multicenter, prospective, open-label registry of the management of patients treated in the hospital for acute heart failure in China. The objective of this study is to investigate the clinical features and prognosis of patients with heart failure, and discover the characteristics of high-risk heart failure patients, and elucidate critical factors which predict the development and outcomes of symptomatic heart failure patients.

1. To elucidate the clinical characteristics and prognostic risks of patients with heart failure.
2. To study the characteristics of high-risk heart failure patients and predict the key factors for the development of symptomatic heart failure patients.
3. To elucidate the compliance of patients with heart failure and the incidence of adverse drug effects.
4. To investigate the effect of self-management on outcomes in patients with heart failure.
5. To elucidate critical factors associated with the development and outcomes of heart failure.
6. To investigate hospitalization expenses for heart failure.

Eligibility criteria: Inclusion Criteria:

- 1. 18 years and older. 2. Meet the diagnostic criteria of China 2018 or JACC/AHA 2017 or ESC 2016 heart failure guidelines.

3. Agree to be tested and sign an informed consent certificate.

Exclusion Criteria:

* 1. Age\<18 years old. 2. Patients who refused to participate. 3. Patients may have a life expectancy of less than 1 years due to non- heart failure clinical conditions.

Primary outcomes:
measure: Mortality of acute decompensated heart failure
timeFrame: 10 years
measure: Re-hospitalization rate
timeFrame: 10 years
Secondary outcomes:
Other outcomes:
Locations:
city: Shanghai
country: China
facility: Shanghai Tenth People's Hospital, Tongji University
state: Shanghai
Study officials:
affiliation: Shanghai Tenthth People's Hospital
name: Dachun Xu, PhD
role: PRINCIPAL_INVESTIGATOR
References:
citation: Su Y, Ma M, Zhang H, Pan X, Zhang X, Zhang F, Lv Y, Yan C. Prognostic value of serum hyponatremia for outcomes in patients with heart failure with preserved ejection fraction: An observational cohort study. Exp Ther Med. 2020 Nov;20(5):101. doi: 10.3892/etm.2020.9231. Epub 2020 Sep 17.