Clinical trial NCT01709617: Carbohydrate Use During and Following Exercise
Official title: Sucrose as a Preferred Carbohydrate in Sports Nutrition
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Carbohydrate Oxidation and Glycogen Utilization During and Following Exercise
Keywords: carbohydrate, glycogen, glucose
Lead sponsor: Maastricht University Medical Center
Sponsor class: OTHER
First posted: 2012-10-18
Enrollment: 17
Sex: MALE
Minimum age (years): 18
Maximum age (years): 40
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: CROSSOVER

Brief summary: Carbohydrates are an integral component of sports nutrition. Providing carbohydrate (CHO) during exercise delays the onset of fatigue and improves exercise performance by maintaining high rates of CHO oxidation. Traditionally, glucose, or glucose polymers have been the preferential CHO source found in sports drinks. However, during the intestinal absorption of large amounts of glucose (\>1.2 g/min), sodium-dependent glucose transporters (SGLT1) may become fully saturated, potentially limiting the rate of exogenous CHO oxidation. In an effort to evade this limitation, research has suggested using multiple transportable carbohydrates in the composition of sports drinks. Multiple transportable carbohydrates are combinations of simple sugars that use different intestinal transporters during the absorption process. Ingesting multiple transportable carbohydrates may enhance the capacity for total intestinal CHO absorption, leading to an increase in the rate of exogenous CHO oxidation. Our purpose will be to examine the disaccharide sucrose in it's ability to provide exogenous fuel during and following prolonged exercise.


Eligibility criteria: Inclusion Criteria:

* Healthy
* Male
* 18 - 40 years of age
* Endurance trained cyclist/triathlete
* VO2 max ≥ 50 ml/kg/min
* BMI \< 25 kg/m2

Exclusion Criteria:

* Use of medication
* Smoking

Primary outcomes:
measure: Exogenous carbohydrate oxidation rate (Part A)
timeFrame: 0 min during trials 1-3
measure: Endogenous carbohydrate oxidation (Part A)
timeFrame: 0 min during trials 1-3
measure: Glycogen utilization (Part B)
timeFrame: immediately post exercise (~90min), during trials 4-6
measure: Exogenous carbohydrate oxidation rate (Part A)
timeFrame: 30 min during trials 1-3
measure: Exogenous carbohydrate oxidation rate (Part A)
timeFrame: 60 min during trials 1-3
measure: Exogenous carbohydrate oxidation rate (Part A)
timeFrame: 90 min during trials 1-3
measure: Exogenous carbohydrate oxidation rate (Part A)
timeFrame: 120 min during trials 1-3
measure: Exogenous carbohydrate oxidation rate (Part A)
timeFrame: 150 min during trials 1-3
measure: Exogenous carbohydrate oxidation rate (Part A)
timeFrame: 180 min during trials 1-3
measure: Endogenous carbohydrate oxidation (Part A)
timeFrame: 30 min during trials 1-3
measure: Endogenous carbohydrate oxidation (Part A)
timeFrame: 60 min during trials 1-3
measure: Endogenous carbohydrate oxidation (Part A)
timeFrame: 90 min during trials 1-3
measure: Endogenous carbohydrate oxidation (Part A)
timeFrame: 120 min during trials 1-3
measure: Endogenous carbohydrate oxidation (Part A)
timeFrame: 150 min during trials 1-3
measure: Endogenous carbohydrate oxidation (Part A)
timeFrame: 180 min during trials 1-3
measure: Glycogen utilization (Part B)
timeFrame: 3 h post exercise during trials 4-6
measure: Glycogen utilization (Part B)
timeFrame: 6 h post exercise during trials 4-6
Secondary outcomes:
measure: Indirect calorimetry (Part A)
timeFrame: every 30 min up to 180 min during trials 1-3
measure: Plasma glucose
timeFrame: every 30 min up to 180 min during trials 1-6
measure: Plasma insulin
timeFrame: every 30 minutes up to 180 min during trials 1-6
Other outcomes:
Locations:
city: Maastricht
country: Netherlands
facility: Maastricht University
state: Limburg
Study officials:
affiliation: Maastricht University
name: Luc van Loon, Ph.D.
role: PRINCIPAL_INVESTIGATOR
References: