Clinical trial NCT04622319: A Study of Trastuzumab Deruxtecan (T-DXd) Versus Trastuzumab Emtansine (T-DM1) in High-risk HER2-positive Participants With Residual Invasive Breast Cancer Following Neoadjuvant Therapy (DESTINY-Breast05)
Official title: A Phase 3, Multicenter, Randomized, Open-Label, Active-Controlled Study of Trastuzumab Deruxtecan (T-DXd) Versus Trastuzumab Emtansine (T-DM1) in Participants With High-Risk HER2-Positive Primary Breast Cancer Who Have Residual Invasive Disease in Breast or Axillary Lymph Nodes Following Neoadjuvant Therapy (DESTINY-Breast05)
Study type: INTERVENTIONAL
Overall status: ACTIVE_NOT_RECRUITING
Phase: PHASE3
Conditions: HER2-Positive Primary Breast Cancer
Residual Invasive Breast Cancer
Keywords: HER2-Positive Primary Breast Cancer
Residual Invasive Breast Cancer
Trastuzumab Deruxtecan
Trastuzumab Emtansine
Lead sponsor: Daiichi Sankyo
Sponsor class: INDUSTRY
Collaborators: name: AstraZeneca
name: NSABP Foundation Inc
name: GBG Forschungs GmbH
name: Spanish Breast Cancer Research Group (SOLTI)
First posted: 2020-11-09
Enrollment: 1600
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: Patients with HER2-positive primary breast cancer (BC) who do not achieve complete response after appropriate neoadjuvant therapy are at higher risk of disease recurrence. More effective treatment options are needed for this patient population. This study will examine the efficacy and safety of trastuzumab deruxtecan (T-DXd) compared with trastuzumab emtansine (T-DM1) in high-risk patients with residual invasive breast cancer following neoadjuvant therapy.

Detailed description: This study will examine trastuzumab deruxtecan (T-DXd) versus trastuzumab emtansine (T-DM1) in patients with HER2-positive primary BC who have residual invasive disease in breast or axillary lymph nodes with higher risk of recurrence, which includes patients who were inoperable at disease presentation or had pathological node-positive status after neoadjuvant therapy.

The primary objective is to compare invasive disease-free survival (IDFS) between T-DXd and T-DM1 treatment arms in this population. The key secondary objective of the study is to evaluate disease-free survival (DFS).

Eligibility criteria: Key Inclusion Criteria:

* Adults ≥18 years old (local regulatory requirements will apply if the legal age of consent for study participation is \>18 years old).
* Pathologically documented HER2-positive breast cancer (BC):

  * HER2-positive expression defined as an immunohistochemistry (IHC) score of 3+ and/or positive by in situ hybridization (ISH) confirmed prior to study randomization.
* Histologically confirmed invasive breast carcinoma.
* Clinical stage at disease presentation: T1-4, N0-3, M0; patients presenting with T1N0 tumors are not eligible.
* Pathologic evidence of residual invasive carcinoma in the breast and/or axillary lymph nodes following completion of neoadjuvant therapy meeting one of the following high-risk criteria:

  * Inoperable breast cancer at presentation (prior to neoadjuvant therapy), defined as clinical stages T4, N0-3, M0 or T1-3, N2-3, M0.
  * Operable at presentation, defined as clinical stages T1-3,N0-1,M0, with axillary node positive disease (ypN1-3) following neoadjuvant therapy.
* Completion of neoadjuvant systemic therapy, including taxane-based chemotherapy and HER2-directed treatment prior to surgery.

  * Systemic therapy must consist of at least 6 cycles of neoadjuvant therapy with a total duration of at least 16 weeks, including at least 9 weeks of trastuzumab (± pertuzumab) and at least 9 weeks of taxane-based chemotherapy to be completed prior to surgery. Patients may have received an anthracycline as part of neoadjuvant therapy in addition to taxane chemotherapy.
* Adequate excision as confirmed per medical records: surgical removal of all clinically evident disease in the breast and axillary lymph nodes.
* An interval of no more than 12 weeks between the date of last surgery and the date of randomization.
* Known hormone receptor (HR) status, per local laboratory assessment, as defined by ASCO-CAP guidelines (≥1%): HR positive status defined by either positive estrogen receptor (ER) and/or positive progesterone receptor (PR).

status. HR-negative status defined by both known negative ER and known negative PR.

* Left ventricular ejection fraction (LVEF) ≥50% within 28 days prior to randomization.
* Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1 at Screening.
* Has adequate organ function within 14 days before randomization.

Key Exclusion Criteria:

* Stage IV (metastatic) BC.
* History of any prior (ipsi- or contralateral) breast cancer except lobular carcinoma in situ (LCIS).
* Evidence of clinically evident gross residual or recurrent disease following neoadjuvant therapy and surgery.
* Prior treatment with T-DXd, T-DM1 or other anti-HER2 antibody-drug conjugate (ADC) or prior enrollment in a clinical study of T-DXd (regardless of treatment arm)
* History of exposure to the following cumulative doses of anthracyclines:

  * Doxorubicin \> 240 mg/m\^2
  * Epirubicin or Liposomal Doxorubicin-Hydrochloride \> 480 mg/m\^2
  * For other anthracyclines, exposure equivalent to doxorubicin \> 240 mg/m\^2
* History of other malignancy within the last 5 years except for appropriately treated CIS of the cervix, nonmelanoma skin carcinoma, Stage I melanoma skin carcinoma, Stage I uterine cancer, or other appropriately treated non-breast malignancies with an outcome similar to those mentioned above.
* History of (noninfectious) interstitial lung disease (ILD)/pneumonitis that required steroids and/or has ILD/pneumonitis noted on computed tomography (CT) scan of the chest at Screening (asymptomatic interstitial changes confined to recent radiation therapy fields are not excluded).
* Known pulmonary compromise resulting from intercurrent pulmonary illnesses including, but not limited to, any underlying pulmonary disorder (eg, pulmonary emboli within three months prior to randomization, severe asthma, severe chronic obstructive pulmonary disease \[COPD\], restrictive lung disease).
* Any autoimmune, connective tissue or inflammatory disorders (eg, Rheumatoid arthritis, Sjogren's, sarcoidosis, etc) where there is documented or a suspicion of pulmonary involvement or pneumonectomy at the time of screening.
* Medical history of myocardial infarction (MI) within 6 months before randomization, symptomatic congestive heart failure (CHF) (New York Heart Association Class II to IV), troponin levels consistent with MI as defined according to the manufacturer 28 days prior to randomization.

Primary outcomes:
measure: Invasive Disease-free Survival (IDFS) in Participants Who Were Administered Trastuzumab Deruxtecan (T-DXd) Compared With Trastuzumab Emtansine (T-DM1) Treatment
timeFrame: Randomization to date of invasive local, axillary or distant recurrence, invasive contralateral breast cancer or death from any cause (whichever occurs first), up to approximately 57 months postdose
Secondary outcomes:
measure: Disease-free Survival (DFS) in Participants Who Were Administered Trastuzumab Deruxtecan (T-DXd) Compared With Trastuzumab Emtansine (T-DM1) Treatment
timeFrame: Randomization to date of the first occurrence of an IDFS event including second primary non-breast cancer event or contralateral or ipsilateral ductal carcinoma in situ (whichever occurs first), up to approximately 81 months postdose
measure: Overall Survival (OS) in Participants Who Were Administered Trastuzumab Deruxtecan (T-DXd) Compared With Trastuzumab Emtansine (T-DM1) Treatment
timeFrame: Randomization to date of death from any cause, up to approximately 81 months postdose
measure: Distant Recurrence-free Interval (DRFI) in Participants Who Were Administered Trastuzumab Deruxtecan (T-DXd) Compared With Trastuzumab Emtansine (T-DM1) Treatment
timeFrame: Randomization to date of distant recurrence, up to approximately 81 months postdose
measure: Brain Metastases-free Interval (BMFI) in Participants Who Were Administered Trastuzumab Deruxtecan (T-DXd) Compared With Trastuzumab Emtansine (T-DM1) Treatment
timeFrame: Randomization to date of brain metastasis, up to approximately 81 months postdose
measure: Percentage of Treatment-emergent Adverse Events in Participants Who Were Administered Trastuzumab Deruxtecan (T-DXd) Compared With Trastuzumab Emtansine (T-DM1) Treatment
timeFrame: Baseline up to approximately 81 months postdose
measure: Serum Concentrations of Trastuzumab Deruxtecan (T-DXd), total anti-HER2 antibody, and Active Metabolite MAAA-1181a
timeFrame: Pre-dose on Day 1 of Cycles 1, 4 and 10 and within 15 minutes post-dose on Day 1 of Cycles 1 and 4 (each cycle is 21 days)
measure: Percentage of Participants Positive for Treatment-emergent Anti-drug Antibodies (ADAs) in Participants Who Were Administered Trastuzumab Deruxtecan (T-DXd)
timeFrame: Baseline up to approximately 81 months postdose
Other outcomes:
Locations:
city: Anaheim
country: United States
facility: The Oncology Institute of Hope & Innovation
state: California
city: Anaheim
country: United States
facility: Kaiser Permanente
state: California
city: Baldwin Park
country: United States
facility: Kaiser Permanente
state: California
city: Bellflower
country: United States
facility: Kaiser Permanente
state: California
city: Fontana
country: United States
facility: Kaiser Permanente
state: California
city: Fountain Valley
country: United States
facility: Orange Coast Blood and Cancer Care
state: California
city: Harbor City
country: United States
facility: Kaiser Permanente
state: California
city: Irvine
country: United States
facility: Kaiser Permanente
state: California
city: Long Beach
country: United States
facility: Long Beach Memorial TCI
state: California
city: Los Angeles
country: United States
facility: Kaiser Permanente
state: California
city: Ontario
country: United States
facility: Kaiser Permanente
state: California
city: Panorama City
country: United States
facility: Kaiser Permanente
state: California
city: Riverside
country: United States
facility: Kaiser Permanente
state: California
city: San Diego
country: United States
facility: Kaiser Permanente
state: California
city: San Marcos
country: United States
facility: Kaiser Permanente
state: California
city: West Los Angeles
country: United States
facility: Kaiser Permanente
state: California
city: Woodland Hills
country: United States
facility: Kaiser Permanente
state: California
city: Altamonte Springs
country: United States
facility: SCRI FCS North- Altamonte
state: Florida
city: Bonita Springs
country: United States
facility: SCRI FCS South- Bonita
state: Florida
city: Brandon
country: United States
facility: SCRI FCS North- Brandon Cancer Center
state: Florida
city: Cape Coral
country: United States
facility: SCRI FCS South- North Fort Myers
state: Florida
city: Clearwater
country: United States
facility: SCRI FCS North- Mease/Clearwater
state: Florida
city: Fort Myers
country: United States
facility: SCRI FCS South
state: Florida
city: Fort Myers
country: United States
facility: SCRI FCS South- Colonial
state: Florida
city: Fort Myers
country: United States
facility: SCRI FCS South- Gladiolus
state: Florida
city: Gainesville
country: United States
facility: SCRI FCS North- Gainesville Cancer Center
state: Florida
city: Jacksonville
country: United States
facility: Baptist MD Anderson Cancer Center
state: Florida
city: Lady Lake
country: United States
facility: SCRI FCS North- Villages East
state: Florida
city: Lakewood Ranch
country: United States
facility: SCRI FCS South- Lakewood Ranch
state: Florida
city: Largo
country: United States
facility: SCRI FCS North- Largo/Highland
state: Florida
city: Lecanto
country: United States
facility: SCRI FCS North- Lecanto
state: Florida
city: Naples
country: United States
facility: SCRI FCS South- Naples West
state: Florida
city: Naples
country: United States
facility: SCRI FCS South- Naples/Goodlette
state: Florida
city: New Port Richey
country: United States
facility: SCRI FCS North- New Port Richey
state: Florida
city: Ocala
country: United States
facility: SCRI FCS North- Ocala
state: Florida
city: Ocoee
country: United States
facility: Orlando Health
state: Florida
city: Orange City
country: United States
facility: SCRI FCS North- Orange City
state: Florida
city: Orlando
country: United States
facility: Orlando Health
state: Florida
city: Orlando
country: United States
facility: SCRI FCS North- Orlando Downtown
state: Florida
city: Port Charlotte
country: United States
facility: SCRI FCS South- Port Charlotte
state: Florida
city: Saint Petersburg
country: United States
facility: SCRI FCS North- St. Anthony's/St. Petersburg
state: Florida
city: Saint Petersburg
country: United States
facility: SCRI FCS North
state: Florida
city: Sarasota
country: United States
facility: SCRI FCS South- Sarasota-Cattleman
state: Florida
city: Sarasota
country: United States
facility: SCRI FCS South-Sarasota-Downtown
state: Florida
city: Spring Hill
country: United States
facility: SCRI FCS North- Spring Hill
state: Florida
city: Tampa
country: United States
facility: SCRI FCS North- Tampa Cancer Center
state: Florida
city: Tavares
country: United States
facility: SCRI FCS North- Tavares
state: Florida
city: Venice
country: United States
facility: SCRI FCS South- Venice Healthpark
state: Florida
city: Weston
country: United States
facility: Cleveland Clinic-Weston
state: Florida
city: Winter Park
country: United States
facility: SCRI FCS North- Winter Park
state: Florida
city: Elmhurst
country: United States
facility: Elmhurst Memorial Hospital- Nancy W. Knowles Cancer Center
state: Illinois
city: Naperville
country: United States
facility: Edward Cancer Center
state: Illinois
city: Plainfield
country: United States
facility: Edward Cancer Center Plainfield
state: Illinois
city: Lexington
country: United States
facility: University of Kentucky, Markey Cancer Center, Clinical Research Organization
state: Kentucky
city: Louisville
country: United States
facility: Baptist Health Louisville
state: Kentucky
city: Baton Rouge
country: United States
facility: LSU Health Baton Rouge North Clinic
state: Louisiana
city: Baton Rouge
country: United States
facility: Our Lady of the Lake Physician Group-Medical Oncology
state: Louisiana
city: Baton Rouge
country: United States
facility: Mary Bird Perkins Cancer Center
state: Louisiana
city: Covington
country: United States
facility: Ochsner Hematology Oncology North Shore - Covington (West Region)
state: Louisiana
city: New Orleans
country: United States
facility: Ochsner Clinic Foundation
state: Louisiana
city: Baltimore
country: United States
facility: MedStar Franklin Square Medical Center-Harry and Jeanette Weinberg Cancer Institute
state: Maryland
city: Baltimore
country: United States
facility: MedStar Franklin Square Cancer Center at Loch Raven Campus
state: Maryland
city: Frederick
country: United States
facility: Frederick Health-James M Stockman Cancer Center
state: Maryland
city: Silver Spring
country: United States
facility: Maryland Oncology Hematology
state: Maryland
city: Silver Spring
country: United States
facility: Holy Cross Hospital
state: Maryland
city: Bronx
country: United States
facility: Montefiore Medical Center
state: New York
city: Cary
country: United States
facility: Waverly Hematology Oncology
state: North Carolina
city: Rocky Mount
country: United States
facility: UNC Cancer Care at Nash
state: North Carolina
city: Winston-Salem
country: United States
facility: Wake Forest Baptist Medical Center
state: North Carolina
city: Cleveland
country: United States
facility: Cleveland Clinic - Hillcrest
state: Ohio
city: Cleveland
country: United States
facility: Cleveland Clinic-Fairview
state: Ohio
city: Cleveland
country: United States
facility: Cleveland Clinic
state: Ohio
city: Warrensville Heights
country: United States
facility: Cleveland Clinic South Pointe
state: Ohio
city: Bethel Park
country: United States
facility: UPMC Upper St. Clair
state: Pennsylvania
city: Cranberry Township
country: United States
facility: UPMC Passavant Cranberry/North
state: Pennsylvania
city: Erie
country: United States
facility: UPMC Erie
state: Pennsylvania
city: Erie
country: United States
facility: AHN Cancer Inst at St Vincent
state: Pennsylvania
city: Greensburg
country: United States
facility: UPMC Arnold Palmer-Mt View
state: Pennsylvania
city: Harrisburg
country: United States
facility: UPMC Pinnacle-Ortenzio Cancer Center
state: Pennsylvania
city: Harrisburg
country: United States
facility: UMPC Pinnacle Pharmacy
state: Pennsylvania
city: Jefferson Hills
country: United States
facility: AHN Cancer Insititute at Jefferson
state: Pennsylvania
city: Monroeville
country: United States
facility: AHN Cancer Institute at Forbes
state: Pennsylvania
city: Monroeville
country: United States
facility: UPMC Monroeville
state: Pennsylvania
city: Mount Pleasant
country: United States
facility: UPMC Arnold Palmer-Mt Pleasant
state: Pennsylvania
city: N. Huntingdon
country: United States
facility: UPMC Arnold Palmer-Norwin
state: Pennsylvania
city: Pittsburgh
country: United States
facility: Allegheny General Hospital
state: Pennsylvania
city: Pittsburgh
country: United States
facility: Magee
state: Pennsylvania
city: Pittsburgh
country: United States
facility: UPMC St. Margaret
state: Pennsylvania
city: Pittsburgh
country: United States
facility: AHN Cancer Inst at West Penn
state: Pennsylvania
city: Pittsburgh
country: United States
facility: UPMC Hillman Cancer Center
state: Pennsylvania
city: Pittsburgh
country: United States
facility: UPMC Passavant HOA
state: Pennsylvania
city: Pittsburgh
country: United States
facility: UPMC Passavant OHA
state: Pennsylvania
city: Uniontown
country: United States
facility: UPMC Uniontown
state: Pennsylvania
city: Washington
country: United States
facility: UPMC Washington
state: Pennsylvania
city: West Reading
country: United States
facility: Reading Hospital, McGlinn Cancer Institute
state: Pennsylvania
city: Wexford
country: United States
facility: AHN Cancer Institute at Wexford
state: Pennsylvania
city: York
country: United States
facility: UPMC Pinnacle-Memorial Cancer Center
state: Pennsylvania
city: Franklin
country: United States
facility: SCRI TO Nashville- Franklin Tennessee Oncology, PLLC
state: Tennessee
city: Gallatin
country: United States
facility: SCRI TO Nashville- Gallatin Tennessee Oncology, PLLC
state: Tennessee
city: Hendersonville
country: United States
facility: SCRI TO Nashville- Hendersonville Tennessee Oncology, PLLC
state: Tennessee
city: Hermitage
country: United States
facility: SCRI TO Nashville- Summit Tennessee Oncology, PLLC
state: Tennessee
city: Kingsport
country: United States
facility: Regional Cancer Center at Indian Path Community Hospital
state: Tennessee
city: Lebanon
country: United States
facility: SCRI TO Nashville- Lebanon Tennessee Oncology, PLLC
state: Tennessee
city: Nashville
country: United States
facility: SCRI TO Nashville- St. Thomas Midtown Tennessee Oncology, PLLC
state: Tennessee
city: Nashville
country: United States
facility: Tennessee Oncology Nashville / Sarah Cannon
state: Tennessee
city: Nashville
country: United States
facility: SCRI TO Nashville- St. Thomas West Tennessee Oncology, PLLC
state: Tennessee
city: Nashville
country: United States
facility: SCRI TO Nashville- Skyline Tennessee Oncology, PLLC
state: Tennessee
city: Nashville
country: United States
facility: SCRI TO Nashville- Southern Hills Tennessee Oncology, PLLC
state: Tennessee
city: Smyrna
country: United States
facility: SCRI TO Nashville- Smyrna Tennessee Oncology, PLLC
state: Tennessee
city: Baytown
country: United States
facility: Houston Methodist Baytown
state: Texas
city: Houston
country: United States
facility: Houston Methodist
state: Texas
city: Houston
country: United States
facility: Houston Methodist Willowbrook
state: Texas
city: Houston
country: United States
facility: Houston Methodist West
state: Texas
city: Nassau Bay
country: United States
facility: Houston Methodist Clear Lake
state: Texas
city: Sugar Land
country: United States
facility: Houston Methodist Sugarland
state: Texas
city: The Woodlands
country: United States
facility: Houston Methodist Woodlands
state: Texas
city: Bristol
country: United States
facility: Wellmont Medical Associates Oncology & Hematology
state: Virginia
city: Charlottesville
country: United States
facility: University of Virginia
state: Virginia
city: Richmond
country: United States
facility: Virginia Commonwealth University Massey Cancer Center
state: Virginia
city: Auburn
country: United States
facility: MultiCare Cancer Center Aurburn
state: Washington
city: Gig Harbor
country: United States
facility: MultiCare Regional Cancer Center - Gig Harbor
state: Washington
city: Puyallup
country: United States
facility: MultiCare Cancer Center Puyallup
state: Washington
city: Spokane
country: United States
facility: MultiCare Institute for Research & Innovation
state: Washington
city: Spokane
country: United States
facility: MultiCare Institute for Research & Innovation
state: Washington
city: Tacoma
country: United States
facility: MultiCare Cancer Center Tacoma
state: Washington
city: Morgantown
country: United States
facility: West Virginia University
state: West Virginia
city: Capital
country: Argentina
facility: Centro Oncologico Riojano Integral
state: La Rioja
city: Rosario
country: Argentina
facility: Sanatorio Británico de Rosario
state: Santa Fe
city: Rosario
country: Argentina
facility: Instituto de Oncología de Rosario
state: Santa Fe
city: Buenos Aires
country: Argentina
facility: COIBA
city: Caba
country: Argentina
facility: Instituto Alexander Fleming
city: San Juan
country: Argentina
facility: CER San Juan
city: Adelaide
country: Australia
facility: Royal Adelaide Hospital
city: Camperdown
country: Australia
facility: Chris O Brien Lifehouse
city: Clayton
country: Australia
facility: Monash Health
city: Heidelberg
country: Australia
facility: Austin Hospital- Olivia Newto-John Cancer and Wellness Centre
city: Melbourne
country: Australia
facility: Peter MacCallum Cancer Centre
city: Nedlands
country: Australia
facility: Breast Cancer Research Centre - WA
city: Saint Leonards
country: Australia
facility: Genesis Care Northern Cancer
city: Subiaco
country: Australia
facility: St John of God Hospital - Bendat Family Comprehensive Cancer Centre (BFCCC)
city: Wollongong
country: Australia
facility: Southern Medical Day Care Centre
city: Edegem
country: Belgium
facility: Antwerp University Hospital
state: Antwerpen
city: Gent
country: Belgium
facility: UZ Gent
state: O. Vl.
city: Brasschaat
country: Belgium
facility: Algemeen Ziekenhuis AZ Klina - Borstkliniek
city: Brussels
country: Belgium
facility: Institut Jules Bordet Brussels Belgium
city: Brussels
country: Belgium
facility: Cliniques Universitaires Saint-Luc
city: Leuven
country: Belgium
facility: UZ Leuven - Campus Gasthuisberg
city: Liège
country: Belgium
facility: CHU Liege
city: Wilrijk
country: Belgium
facility: GZA Hospitals Campus Sint- Augustinus
city: Brasília
country: Brazil
facility: Hospital Sirio-Libanes HSL - Centro de Oncologia - Brasilia
state: Federal District
city: Curitiba
country: Brazil
facility: Hospital Erasto Gaertner
state: Parana
city: Caxias Do Sul
country: Brazil
facility: Fundação Universidade de Caxias do Sul Instituto de Pesquisas em Saúde IPS-UCS
state: Rio Grande Do Sul
city: Porto Alegre
country: Brazil
facility: Hospital Sao Lucas PUCRS
state: RS
city: Barretos
country: Brazil
facility: Fundacao Pio XII-Hospital de Cancer de Barretos
state: SP
city: Santo André
country: Brazil
facility: CEPHO - Centro de Estudos e Pesquisas de Hematologia e Oncologia
state: SP
city: São José Do Rio Preto
country: Brazil
facility: Hospital de Base de Sao Jose do Rio Preto
state: SP
city: Rio De Janeiro
country: Brazil
facility: INCA - Instituto Nacional do Cancer / Hospital do Cancer HCIII
city: São Paulo
country: Brazil
facility: Instituto do Cancer do Estado de Sao Paulo (ICESP)
city: Calgary
country: Canada
facility: Tom Baker Cancer Centre
state: Alberta
city: Ottawa
country: Canada
facility: The Ottawa Hospital Cancer Centre
state: Ontario
city: Montréal
country: Canada
facility: CIUSSSS de l'Est-de-l'Ile-de-Montréal - Installation Hôpital Maisonneuve-Rosemont
state: Quebec
city: Montréal
country: Canada
facility: CHUM
state: Quebec
city: Montréal
country: Canada
facility: Jewish General Hospital Segal Cancer Centre
state: Quebec
city: Montréal
country: Canada
facility: McGill University Health Centre - Cedars Cancer Centre
state: Quebec
city: Québec
country: Canada
facility: CHU de Quebec - Hopital du Saint-Sacrement
state: Quebec
city: Santiago
country: Chile
facility: Hospital Clinico Universidad de Chile
state: RM
city: Santiago
country: Chile
facility: Fundacion Arturo Lopez Perez
city: Temuco
country: Chile
facility: SIM CRC
city: Beijing
country: China
facility: Peking University Cancer Hospital
city: Beijing
country: China
facility: Peking University Third Hospital
city: Changchun
country: China
facility: Jilin University JLU - First Affiliated Hospital
city: Chengdu
country: China
facility: Sichuan University - West China Hospital
city: Chongqing
country: China
facility: Chongqing Medical University - The First Affiliated Hospital
city: Fuzhou
country: China
facility: Union Hospital of Fujian Medical University
city: Guangzhou
country: China
facility: Sun Yat-sen Memorial Hospital
city: Guangzhou
country: China
facility: Guangdong Academy of Medical Science
city: Hangzhou
country: China
facility: Zhejiang Cancer Hospital
city: Hangzhou
country: China
facility: Second Affiliated Hospital of Zhejiang University
city: Harbin
country: China
facility: Harbin Medical University Cancer Hospital
city: Jinan
country: China
facility: Shandong Cancer Hospital
city: Nanchang
country: China
facility: Nanchang University - The First Affiliated Hospital
city: Nanjing
country: China
facility: Nanjing Medical University NMU - Jiangsu Province Hospital
city: Shanghai
country: China
facility: Fudan University Cancer Hospital
city: Shijiazhuang
country: China
facility: The 4th Hospital of Heibei Medical University
city: Xiamen
country: China
facility: The First Affiliated Hospital of Xiamen University
city: Brno
country: Czechia
facility: University Hospital Brno
city: Prague
country: Czechia
facility: Fakultni nemocnice Kralovske Vinohrady
city: Aalborg
country: Denmark
facility: Aalborg University Hospital
city: Aarhus
country: Denmark
facility: Aarhus University Hospital
city: Copenhagen
country: Denmark
facility: Rigshospitalet
city: Odense
country: Denmark
facility: Odense University Hospital
city: Syddanmark
country: Denmark
facility: Soenderborg sygehus
city: Bordeaux
country: France
facility: Clinique Tivoli Ducos - Centre dOncologie et de Radiotherapie a Bordeaux
state: Gironde
city: Toulouse
country: France
facility: Institut Claudius Regaud
state: Haute Garonne
city: Saint-Priest-en-Jarez
country: France
facility: Institut De Cancerologie De La Loire
state: Loire
city: Metz cedex 03
country: France
facility: CHR Metz-Thionville
state: Lorraine
city: Bordeaux
country: France
facility: Institut Bergonie
city: Dijon
country: France
facility: Centre Georges François Leclerc
city: La Roche-sur-Yon
country: France
facility: CHD Vendee
city: La Tronche
country: France
facility: Centre Hosp Univ de Grenoble CHUG
city: Lille
country: France
facility: Centre Oscar Lambret
city: Lyon
country: France
facility: Centre Leon Berard
city: Marseille
country: France
facility: Institut Paoli-Calmettes
city: Montpellier
country: France
facility: Centre de Cancérologie du Grand Montpellier
city: Nancy
country: France
facility: The Sel of Centre dOncologie de Gentilly
city: Nice
country: France
facility: Centre Antoine Lacassagne
city: Paris
country: France
facility: Hospital St Louis
city: Paris
country: France
facility: Hopital Georges Pompidou
city: Paris
country: France
facility: IUC AP-HP. Sorbonne Université, Hôpital Tenon
city: Poitiers
country: France
facility: CHU de Poitiers
city: Rennes
country: France
facility: Centre Eugene Marquis
city: Saint-Herblain
country: France
facility: Institut de cancerologie de l'ouest
city: Strasbourg
country: France
facility: Strasbourg Europe Cancer Institute
city: Augsburg
country: Germany
facility: Gemeinschaftspraxis Dres. Halder / Bangerter
city: Berlin
country: Germany
facility: Cahrité Campus Mitte
city: Berlin
country: Germany
facility: Praxis Dr. med. J. Schilling
city: Berlin
country: Germany
facility: MediOnko-Institut GbR, Praxisklinik Krebsheilkunde
city: Berlin
country: Germany
facility: DRK Kliniken Berlin Köpenick
city: Berlin
country: Germany
facility: Helios Klinikum Berlin-Buch
city: Berlin
country: Germany
facility: Onkologische Schwerpunktpraxis
city: Bielefeld
country: Germany
facility: Onkologische Schwerpunktpraxis
city: Braunschweig
country: Germany
facility: Studien GbR Braunschweig
city: Bremen
country: Germany
facility: Klinikum Bremen Mitte
city: Bremen
country: Germany
facility: Frauenklinik DIAKO Bremen
city: Böblingen
country: Germany
facility: Klinikverbund Südwest Kliniken Böblingen Frauenklinik Böblingen
city: Chemnitz
country: Germany
facility: Klinikum Chemnitz gGmbH
city: Deggendorf
country: Germany
facility: DONAUISAR Klinikum
city: Dortmund
country: Germany
facility: Klinikum Dortmund gGmbH
city: Dortmund
country: Germany
facility: St.-Johannes-Hospital Dortmund, Dept. of Obstetrics/Gynecology
city: Dresden
country: Germany
facility: Onkologische Schwerpunktpraxis
city: Dresden
country: Germany
facility: University Hospital Dresden
city: Dresden
country: Germany
facility: Onkozentrum Dresden
city: Düsseldorf
country: Germany
facility: Universitätsklinikum Düsseldorf, Klinik für Frauenheilkunde & Geburtshilfe
city: Erlangen
country: Germany
facility: Frauenklinik der Universität Erlangen
city: Essen
country: Germany
facility: Kliniken Essen-Mitte, Klinik für Senologie/ Interdisziplinäres Brustzentrum
city: Essen
country: Germany
facility: Universitätsklinikum Essen, Frauenklinik
city: Esslingen
country: Germany
facility: Klinikum Esslingen GmbH
city: Frankfurt am main
country: Germany
facility: AGAPLESION Markus Krankenhaus
city: Frankfurt
country: Germany
facility: Frankfurt University Department of Gynecology and Obstetrics
city: Frankurt am Main
country: Germany
facility: Centrum for Haematology and Oncology
city: Freiburg
country: Germany
facility: Universitätsklinik Freiburg, Klinik für Frauenheilkunde
city: Gelsenkirchen
country: Germany
facility: Evangelische Kliniken Gelsenkirchen
city: Georgsmarienhütte
country: Germany
facility: MVZ II der Niels-Stensen-Kliniken
city: Gera
country: Germany
facility: SRH Waldklinikum Gera, Brustzentrum Ostthüringen
city: Goslar
country: Germany
facility: MVZ Onkologische Kooperation Harz
city: Halle/saale
country: Germany
facility: Krankenhaus St. Elisabeth und St. Barbara Halle/Saale
city: Hamburg
country: Germany
facility: University Medical Center
city: Hamburg
country: Germany
facility: Mammazentrum HH am Krankenhaus Jerusalem
city: Hamburg
country: Germany
facility: Albertinen Krankenhaus
city: Hannover
country: Germany
facility: Gynäkologisch-Ontologische Praxis Hannover
city: Hannover
country: Germany
facility: DIAKOVERE Henriettenstift Frauenklinik
city: Hildesheim
country: Germany
facility: Gemeinschaftspraxis Frauenärzte am Bahnhofsplatz
city: Homburg
country: Germany
facility: Department of Gyencology and Obstetrics, Saarland University Hospital
city: Karlsruhe
country: Germany
facility: ViDia Christliche Kliniken Karlsruhe
city: Kassel
country: Germany
facility: Elisabethkrankenhaus Kassel, Brustzentrum
city: Kassel
country: Germany
facility: Klinikum Kassel
city: Kiel
country: Germany
facility: University Hospital Schleswig-Holstein
city: Koblenz
country: Germany
facility: Institut für Versorgungsforschung in der Onkologie
city: Köln
country: Germany
facility: Unifrauenklinik Köln - Studienzentrum Gynäkologie
city: Köln
country: Germany
facility: St. Elisabeth Hospital
city: Köln
country: Germany
facility: Kliniken der Stadt Köln / Brustzentrum Holweide
city: Limburg
country: Germany
facility: St. Vincenz KH Limburg
city: Luebeck
country: Germany
facility: UKSH Campus Lübeck
city: Magdeburg
country: Germany
facility: Universitäts-Frauenklinik
city: Mainz
country: Germany
facility: Department of Obstetrics and Gynecology
city: Mannheim
country: Germany
facility: Medzinische Fakultät Mannheim, Universität Heidelberg
city: Memmingen
country: Germany
facility: Klinikum Memmingen
city: Minden
country: Germany
facility: Johannes Wesling Klinikum Minden, Hämatologie-Onkologie/Brustzentrum
city: Muenchen
country: Germany
facility: Rotkreuzklinikum München, Frauenklinik
city: Munich
country: Germany
facility: Gynaekologie Arabella
city: Mönchengladbach
country: Germany
facility: Brustzentrum Niederrhein
city: München
country: Germany
facility: Medizinisches Versorgungszentrum für Hämatologie und Onkologie München MVZ GmbH
city: München
country: Germany
facility: LMU Klinikum/ Klinik und Poliklinik für Frauenheilkunde und Geburtshilfe
city: Neuss
country: Germany
facility: Dept. OB/GYN Johanna Etienne Krankenhaus
city: Offenburg
country: Germany
facility: Ortenau Klinikum Offenburg-Kehl
city: Oldenburg
country: Germany
facility: Klinikum Oldenburg AöR
city: Paderborn
country: Germany
facility: Frauenklinik St. Louise - St. Vincenz- Krankenhaus GmbH
city: Potsdam
country: Germany
facility: Klinikum Ernst von Bergmann
city: Ravensburg
country: Germany
facility: Studienzentrum Onkologie Ravensburg
city: Recklinghausen
country: Germany
facility: Oncologianova GmbH
city: Rosenheim
country: Germany
facility: RoMed Klinikum Rosenheim
city: Rostock
country: Germany
facility: Univ-Hospital, Dept Ob/Gyn
city: Saarbrücken
country: Germany
facility: CaritasKlinikum St. Theresia
city: Speyer
country: Germany
facility: Onkologische Schwerpunktpraxis Speyer
city: Stralsund
country: Germany
facility: G.SUND Gynäkologie Kompetenzzentrum
city: Torgau
country: Germany
facility: KKH Torgau
city: Trier
country: Germany
facility: Klinikum Mutterhaus
city: Troisdorf
country: Germany
facility: Praxisnetzwerk Hämatologie/Internistische Onkologie
city: Tuebingen
country: Germany
facility: Frauenklinik
city: Ulm
country: Germany
facility: Universitätsfrauenklinik Ulm
city: Villingen-Schwenningen
country: Germany
facility: Schwarzwald - Baar Klinikum Frauenklinik
city: Wernigerode
country: Germany
facility: Harzklinikum Dorothea Christiane Erxleben
city: Witten
country: Germany
facility: St. Anna Hospital Brustzentrum
city: Worms
country: Germany
facility: Klinikum Worms gGmbH
city: Athens
country: Greece
facility: General Hospital of Athens Alexandra Clinic
state: Attiki
city: Heraklion
country: Greece
facility: University General Hospital of Heraklion
state: Crete
city: Patras
country: Greece
facility: University General Hospital of Patras
state: Western Greece
city: Patras
country: Greece
facility: General Hospital of Patras Agios Andreas
city: Hong Kong
country: Hong Kong
facility: Pamela Youde Nethersole Eastern Hospital PYNEH
city: Hong Kong
country: Hong Kong
facility: The Chinese University of Hong Kong (CUHK) - Prince of Wales Hospital (PWH)
city: Pok Fu Lam
country: Hong Kong
facility: The University of Hong Kong (HKU) - Queen Mary Hospital (QMH)
city: Dublin
country: Ireland
facility: Saint Vincents University Hospital
state: Ie-d
city: Dublin
country: Ireland
facility: St. James Hospital
state: Leinster
city: Cork
country: Ireland
facility: University College Cork
city: Dublin
country: Ireland
facility: Mater Misericordiae University Hospital
city: Limerick
country: Ireland
facility: University Hospital Limerick
city: Be'er Sheva
country: Israel
facility: Soroka MC
state: Hadarom
city: Ramat Gan
country: Israel
facility: Sheba Medical Center
state: Tel Aviv
city: Jerusalem
country: Israel
facility: Hadassah Medical Center
city: Petah tikva
country: Israel
facility: Rabin Medical Center
city: Catania
country: Italy
facility: Azienda Ospedaliera Garibaldi-Nesima
state: CT
city: Milan
country: Italy
facility: Istituto Europeo di Oncologia
state: MI
city: Ancona
country: Italy
facility: Clinica Oncologica, Ospedali Riuniti Umberto 1
city: Aviano
country: Italy
facility: Centro di Riferimento Oncologico di Aviano - SOC Oncologia Medica e Prevenzione Oncologica
city: Bari
country: Italy
facility: Istituto Oncologico di Bari
city: Belluno
country: Italy
facility: Azienda ULSS n. 1 Dolomiti
city: Bologna
country: Italy
facility: Policlinico S.Orsola-Malpighi SSD Oncologia Medica Addarii
city: Bologna
country: Italy
facility: SSD Oncologia Medica
city: Brindisi
country: Italy
facility: Presidio Ospedaliero di Summa - Antonio Perrino
city: Candiolo
country: Italy
facility: Istituto di Candiolo - IRCCS
city: Genova
country: Italy
facility: Ospedale Poli SAN MARTINO
city: Grosseto
country: Italy
facility: Area Vasta Sud Est Sede Operativa Grosseto
city: Grosseto
country: Italy
facility: Azienda Usl Toscana sud est
city: Milano
country: Italy
facility: IRCCS Ospedale San Raffaele
city: Modena
country: Italy
facility: University Hospital of Modena
city: Napoli
country: Italy
facility: INT Fondazione Pascale
city: Padova
country: Italy
facility: Istituto Oncologico Veneto IRCCS
city: Pavia
country: Italy
facility: ICS Maugeri IRCCS
city: Perugia
country: Italy
facility: Azienda Ospedaliera di Perugia
city: Torino
country: Italy
facility: A.O.U. Citta della Salute e della Scienza di Torino
city: Akashi City
country: Japan
facility: Hyogo Cancer Center
city: Chuo-Ku
country: Japan
facility: National Cancer Center (NCC) - Tsukiji Campus - National Cancer Center Hospital (NCCH)
city: Fukuoka City
country: Japan
facility: National Hospital Organization - National Kyushu Cancer Center
city: Hiroshima City
country: Japan
facility: Hiroshima City Hiroshima Citizens Hospital
city: Isehara City
country: Japan
facility: Tokai University Hospital - Isehara Campus
city: Kagoshima City
country: Japan
facility: Sagara Hospital
city: Kashiwa City
country: Japan
facility: National Cancer Center Hospital East (NCCHE) - Kashiwa Campus
city: Koto-Ku
country: Japan
facility: Japanese Foundation for Cancer Research (JFCR) - The Cancer Institute Hospital - Breast Oncology Center
city: Kyoto
country: Japan
facility: Kyoto University Hospital
city: Matsuyama City
country: Japan
facility: National Hospital Organization (NHO) - Shikoku Cancer Center
city: Nagoya City
country: Japan
facility: Aichi Cancer Center Hospital
city: Niigata City
country: Japan
facility: Niigata Cancer Center Hospital
city: Nishinomiya City
country: Japan
facility: Hyogo College of Medicine Hospital
city: Okayama City
country: Japan
facility: Okayama University Hospital
city: Osaka City
country: Japan
facility: National Hospital Organization - Osaka National Hospital (ONH)
city: Osaka City
country: Japan
facility: Osaka International Cancer Institute (OICI)
city: Saitama
country: Japan
facility: Saitama Cancer Center
city: Sapporo City
country: Japan
facility: National Hospital Organization - Hokkaido Cancer Center
city: Sayama City
country: Japan
facility: Kindai University (Kinki University) - Faculty of Medicine (Kinki University School of Medicine (KUSM)) - Kindai University Hospital (Kinki University Hospital) - Cancer Center
city: Sendai City
country: Japan
facility: Tohoku University Hospital (TUH) - Clinical Research, Innovation and Education Center (CRIETO)
city: Shinagawa-Ku
country: Japan
facility: Showa University Hospital - Breast Center
city: Shinjuku-Ku
country: Japan
facility: Tokyo Medical University Hospital
city: Shizuoka
country: Japan
facility: Shizuoka Cancer Center (SCC)
city: Yokohama City
country: Japan
facility: Kanagawa Cancer Center Hospital - Kanagawa Cancer Center (Kanagawa Cancer Centre Research Institute)
city: Daegu
country: Korea, Republic of
facility: Kyungpook National University Hospital
city: Gyeonggi-do
country: Korea, Republic of
facility: National Cancer Center
city: Gyeonggi-do
country: Korea, Republic of
facility: CHA Bundang Medical Center CHA University
city: Gyeonggi-do
country: Korea, Republic of
facility: Seoul National University Bundang Hospital
city: Incheon
country: Korea, Republic of
facility: Gachon University Gil Medical Center
city: Irwon-dong
country: Korea, Republic of
facility: Samsung Medical Center
city: Seoul
country: Korea, Republic of
facility: Korea University Anam Hospital
city: Seoul
country: Korea, Republic of
facility: Seoul National University Hospital
city: Seoul
country: Korea, Republic of
facility: Severance Hospital
city: Songpa-gu
country: Korea, Republic of
facility: Asan Medical Center
city: Yongsan
country: Korea, Republic of
facility: Soon Chun Hyang Central Medical Center (SCHMC)
city: Torreon
country: Mexico
facility: CIMAB S.A. de C.V
state: Coahuila
city: Guadalajara
country: Mexico
facility: Hospital Civil de Guadalajara Fray Antonio Alcalde
state: JAL
city: Monterrey
country: Mexico
facility: Consultorio del Dr. Joaqun Gabriel Reinoso Toledo
state: Nuevo Leon
city: Amsterdam
country: Netherlands
facility: Amsterdam UMC - VU Medisch Centrum
state: Noord-Holland
city: Breda
country: Netherlands
facility: Amphia Hospital Breda
city: Rotterdam
country: Netherlands
facility: Erasmus MC - Daniel den Hoed Oncologisch Centrum
city: Lima
country: Peru
facility: Hospital Nacional Arzobispo Loayza
city: Lima
country: Peru
facility: Clinica Ricardo Palma
city: Lima
country: Peru
facility: Instituto Nacional de Enfermedades Neoplasicas INEN
city: Trujillo
country: Peru
facility: Centro de Investigación Clinica Trujillo EIRL
city: Opole
country: Poland
facility: SP Zoz Opolskie Centrum Onkologii IM
state: Opolskie
city: Gdańsk
country: Poland
facility: Uniwersyteckie Centrum Kliniczne
state: Pomorskie
city: Poznań
country: Poland
facility: Centrum Medyczne HCP Sp. z o.o.
state: Wielkopolskie
city: Warsaw
country: Poland
facility: MSCM Cancer Center and Institute of Oncology Department of Breast Cancer and Reconstructive Surgery
city: Łódź
country: Poland
facility: Instytut Centrum Zdrowia Matki Polki
city: Guimarães
country: Portugal
facility: Hospital da Senhora da Oliveira, Guimarães EPE
city: Lisboa
country: Portugal
facility: Instituto Português de Oncologia de Lisboa Francisco Gentil, EPE
city: Lisboa
country: Portugal
facility: Fundação Champalimaud
city: Lisboa
country: Portugal
facility: Centro Hospitalar de Lisboa Ocidental, EPE
city: Lisboa
country: Portugal
facility: Hospital da Luz
city: Lisboa
country: Portugal
facility: Hospital CUF Descobertas
city: Loures
country: Portugal
facility: Hospital Beatriz Ângelo
city: Matosinhos
country: Portugal
facility: Unidade Local de Saúde de Matosinhos, EPE
city: Porto
country: Portugal
facility: Instituto Português de Oncologia do Porto Francisco Gentil, EPE
city: Vila Nova De Gaia
country: Portugal
facility: Centro Hospitalar de Vila Nova de Gaia/Espinho, EPE
city: Cluj-Napoca
country: Romania
facility: Institutul Oncologic Prof. Dr. Ion Chiricuta
state: Cluj
city: Craiova
country: Romania
facility: Onco Clinic Consult SA
state: Dolj
city: Craiova
country: Romania
facility: Centrul de Oncologie Sfantu Nectarie
state: Dolj
city: Bucharest
country: Romania
facility: Institutul Oncologic Bucuresti IOB
city: Arkhangel'sk
country: Russian Federation
facility: SBHI Arkhangelsk Region - Arkhangelsk Clinical Oncological Dispensary
city: Sochi
country: Russian Federation
facility: State Budgetary Healthcare Institution Oncological Dispensary No. 2 of the Ministry of Health of Krasnodar Region
city: Singapore
country: Singapore
facility: National University Cancer Institute
city: Singapore
country: Singapore
facility: National Cancer Center Singapore
city: Bilbao
country: Spain
facility: Hospital Universitario de Basurto
state: Bizkaia
city: El Palmar
country: Spain
facility: Hospital Clínico Universitario Virgen de la Arrixaca
state: Murcia
city: Reus
country: Spain
facility: Hospital Universitario Sant Joan Reus
state: Tarragona
city: Alcorcón
country: Spain
facility: Hospital Universitario Fundación Alcorcón
city: Alicante
country: Spain
facility: Hospital General Universitario de Alicante
city: Alicante
country: Spain
facility: Hospital de San Juan de Alicante
city: Badajoz
country: Spain
facility: Hospital Universitario de Badajoz
city: Barcelona
country: Spain
facility: Hospital del Mar
city: Barcelona
country: Spain
facility: IOB Institute Of Oncology-Hospital Quironsalud Barcelona
city: Barcelona
country: Spain
facility: Hospital Universitari Vall d'Hebron
city: Barcelona
country: Spain
facility: Hospital Clínic de Barcelona
city: Barcelona
country: Spain
facility: Hospital Universitari Mútua Terrassa
city: Barcelona
country: Spain
facility: ALTHAIA, Xarxa Assistencial Universitària de Manresa F.P.
city: Barcelona
country: Spain
facility: Hospital de Mataró
city: Barcelona
country: Spain
facility: ICO Hospitalet
city: Barcelona
country: Spain
facility: ICO Badalona
city: Castellón
country: Spain
facility: Consorcio Hospitalario Provincial de Castelló
city: Coruña
country: Spain
facility: Complejo Hospitalario Universitario A Coruña (CHUA)
city: Cáceres
country: Spain
facility: Hospital Universitario San Pedro de Alcantara
city: Girona
country: Spain
facility: ICO Girona
city: Granada
country: Spain
facility: Hospital Universitario Clínico San Cecilio
city: Jaén
country: Spain
facility: Complejo Hospitalario de Jaen
city: León
country: Spain
facility: Complejo Asistencial Universitario de León
city: Lleida
country: Spain
facility: Hospital Arnau de Vilanova de Lleida
city: Madrid
country: Spain
facility: Clinica Universidad De Navarra, Madrid
city: Madrid
country: Spain
facility: Hospital MD Anderson Cancer Center Madrid
city: Madrid
country: Spain
facility: Hospital Universitario Ramón y Cajal
city: Madrid
country: Spain
facility: Hospital Universitario Fundación Jiménez Díaz
city: Madrid
country: Spain
facility: Hospital Universitario 12 de Octubre
city: Madrid
country: Spain
facility: Hospital Universitario La Paz
city: Madrid
country: Spain
facility: HM Sanchinarro (CIOCC)
city: Madrid
country: Spain
facility: Hospital Universitario Puerta de Hierro de Majadahonda
city: Madrid
country: Spain
facility: Hospital Universitario HM Puerta del Sur
city: Madrid
country: Spain
facility: Hospital Universitario de Fuenlabrada
city: Murcia
country: Spain
facility: Hospital General Universitario Morales Meseguer
city: Málaga
country: Spain
facility: Hospital Universitario Virgen de la Victoria
city: Móstoles
country: Spain
facility: Hospital Universitario Rey Juan Carlos
city: Navarro
country: Spain
facility: Complejo Hospitalario de Navarra
city: Palma De Mallorca
country: Spain
facility: Hospital Universitari Son Espases
city: Palma De Mallorca
country: Spain
facility: Hospital Son Llatzer
city: San Cristobal de la Laguna
country: Spain
facility: Hospital Universitario de Canarias
city: Sant Cugat Del Vallès
country: Spain
facility: Hospital General de Catalunya
city: Santiago De Compostela
country: Spain
facility: Complejo Hospitalario Clínico Universitario de Santiago de Compostela (CHUS)
city: Sevilla
country: Spain
facility: Hospital Universitario Virgen Macarena
city: Sevilla
country: Spain
facility: Hospital Quirón Salud Sagrado Corazón
city: Sevilla
country: Spain
facility: Hospital Universtiario Virgen del Rocio
city: Valencia
country: Spain
facility: Fundación Instituto Valenciano de Oncologia (IVO)
city: Valencia
country: Spain
facility: Hospital Clínico Universitario de Valencia
city: Valencia
country: Spain
facility: Hospital Arnau de Vilanova de Valencia
city: Zaragoza
country: Spain
facility: Hospital Clínico Universitario Lozano Blesa
city: Kaohsiung
country: Taiwan
facility: E-Da Cancer Hospital
state: Yanchao District
city: Beitou
country: Taiwan
facility: Koo Foundation Sun Yat-Sen Cancer Center
city: Chang Hua
country: Taiwan
facility: Changhua Christian Hospital (CCH)
city: Kaohsiung
country: Taiwan
facility: Kaohsiung Medical University Chung-Ho Memorial Hospital
city: Taichung
country: Taiwan
facility: China Medical University Hospital
city: Taichung
country: Taiwan
facility: Taichung Veterans General Hospital
city: Tainan
country: Taiwan
facility: National Cheng Kung University Hospital
city: Tainan
country: Taiwan
facility: Chi Mei Medical Center CMMC - Yongkang Branch
city: Taipei
country: Taiwan
facility: National Taiwan University Hospital NTUH
city: Taipei
country: Taiwan
facility: MacKay Memorial Hospital
city: Taipei
country: Taiwan
facility: Taipei Veterans General Hospital TPVGH
city: Taipei
country: Taiwan
facility: Tri-Service General Hospital
city: Taipei
country: Taiwan
facility: Chang Gung Memorial Hospital CGMH
city: Ankara
country: Turkey
facility: Hacettepe University Cancer Institute
state: İç Anadolu
city: Edirne
country: Turkey
facility: Trakya University Medical Faculty
city: Istanbul
country: Turkey
facility: Istanbul Medeniyet University Medical Faculty
city: İzmir
country: Turkey
facility: Medical Park - Izmir Hastanesi
city: Peterborough
country: United Kingdom
facility: Peterborough City Hospital
state: Cambridgeshire
city: Maidstone
country: United Kingdom
facility: Kent Oncology Centre Maidstone Hospital
state: Kent
city: Manchester
country: United Kingdom
facility: The Christie Hospital
state: Lancashire
city: Wirral
country: United Kingdom
facility: Clatterbridge Cancer Centre
state: Merseyside
city: Nottingham
country: United Kingdom
facility: Nottingham University Hospitals
state: Nottinghamshire
city: Bath
country: United Kingdom
facility: Royal United Hospital Bath NHS Trust - Royal United Hospital RUH
state: Somerset
city: Taunton
country: United Kingdom
facility: Somerset NHS Foundation Trust
state: Somerset
city: Leeds
country: United Kingdom
facility: St. James University Hospital
state: West Yorkshire
city: Bristol
country: United Kingdom
facility: Univeristy Hospitals Bristol NHS Foundation Trust
city: Colchester
country: United Kingdom
facility: Colchester Hospital, East Suffolk & North Essex NHS Foundation Trust
city: Exeter
country: United Kingdom
facility: Royal Devon Exeter NHS Foundation Trust
city: Glasgow
country: United Kingdom
facility: Beatson West of Scotland Cancer Centre
city: London
country: United Kingdom
facility: Guys and St Thomas NHS Foundation Trust
city: London
country: United Kingdom
facility: Charing Cross Hospital
city: Oxford
country: United Kingdom
facility: Oxford University Hospitals NHS Foundation Trust
city: Peterborough
country: United Kingdom
facility: Blackpool Victoria Hospital
Study officials:
affiliation: Daiichi Sankyo
name: Global Clinical Leader
role: STUDY_DIRECTOR
References: