louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT06851975: Research Into Biomarkers Predictive of Survival and Response to Cancer Treatment
Official title: Research Into Biomarkers Predictive of Survival and Response to Cancer Treatment
Study type: INTERVENTIONAL
Overall status: RECRUITING
Phase: NA
Conditions: Cancer
Lead sponsor: Centre Antoine Lacassagne
Sponsor class: OTHER
First posted: 2025-02-28
Enrollment: 40000
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: OTHER

Brief summary: Research into biomarkers predictive of survival and response to cancer treatment


Eligibility criteria: Inclusion Criteria:

* Patient having a blood test, venous line insertion or injection on an implantable venous device scheduled as part of their standard care,
* Patient who has read the information note and stated that he/she has no objections
* Patient who has not objected to the use of this data for medical research purposes
* Patient with social security cover.

Exclusion Criteria:

* Patient already included in the study
* Patient considered to be a vulnerable person; vulnerable persons are defined in article L1121-5 to -8

Primary outcomes:
measure: Prediction
timeFrame: day 1
Secondary outcomes:
Other outcomes:
Locations:
city: Nice
country: France
facility: Centre Antoine Lacassagne
Study officials:
References:
Clinical trial NCT02048475: Electroencephalogram During Desflurane Anaesthesia
Official title: Electroencephalogram During Increasing and Decreasing Desflurane Concentration
Study type: INTERVENTIONAL
Overall status: WITHDRAWN
Phase: PHASE4
Conditions: Anesthesia
Keywords: desflurane
electroencephalogram
Lead sponsor: Tampere University Hospital
Sponsor class: OTHER
First posted: 2014-01-29
Enrollment: 0
Sex: ALL
Minimum age (years): 18
Maximum age (years): 80
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: DIAGNOSTIC

Brief summary: To study the behavior of EEG during changing desflurane concentrations.

Detailed description: The concentration of desflurane will be increased to burst suppression EEG level, and thereafter decreased.

Eligibility criteria: Inclusion Criteria:

* adult patients

Exclusion Criteria:

* pediatric patients

Primary outcomes:
measure: The behavior of EEG indices numbers during the course of anesthesia, with comparison to raw EEG traces
timeFrame: participants will be followed for the duration of surgical anesthesia, an expected average of 1 hour
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
affiliation: Tampere University Hospital
name: Arvi M Yli-Hankala, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT03806075: Study of Accurate Diagnosis and Treatment of Peutz-Jeghers Syndrome
Official title: Molecular Typing and Precise Prevention and Treatment of Peutz-Jeghers Syndrome
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Peutz-Jeghers Syndrome
Keywords: Second generation gene sequencing, gut microbiota, Gastrointestinal polyp syndrome
Lead sponsor: Changhai Hospital
Sponsor class: OTHER
First posted: 2019-01-16
Enrollment: 150
Sex: ALL
Minimum age (years): 5
Maximum age (years): 70
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: NON_RANDOMIZED
Intervention model: PARALLEL
Intervention model description: All patients with Peutz-Jeghers were enrolled and accepted second generation gene sequencing. Then all patients allocated into gene mutation group and no gene mutation group according to if the cases accompany with gene mutation of STK11.
Primary purpose: SUPPORTIVE_CARE

Brief summary: The mutation of STK11 has been regcognized to be the major cause of Peutz-Jeghers syndrome (PJS).The aim of this study was to confirm the mutation rate of gene associated with gastrointestinal malignancies,including STK11, APC,PMS1,et al. Furtherly, the investigators analyze the association of STK11 with gut microbiota.

Detailed description: All patients diagnosed as PJS were enrolled and accepted second generation gene sequencing with their blood specimens. Then all patients allocated into gene mutation group and no gene mutation group according to if the cases accompany with gene mutation of STK11.Also, health persons were enrolled and a case controlled study will be carried out.All patients and health persons accepted 16s rRNA sequencing with their feces specimens.

Eligibility criteria: Inclusion Criteria:

1. Subject with ages from 18-70 years old.
2. Subject diagnosed with Peutz-Jeughers syndrome.
3. Subject without hypertension, diabetes and other gastrointestinal diseases.
4. The consent form has been signed.

Exclusion Criteria:

1. Subject is younger than 18 years or older than 70 years.
2. Subject with hypertension,diabetes and other gastrointestinal diseases.
3. Subject taken or adminstered medicine associated with digestive function during latest 1 month.
4. Pregnant women.

Primary outcomes:
measure: Mutation of gene associated with Peutz-Jeghers syndrome
timeFrame: 2 years
Secondary outcomes:
measure: Intestinal microbiota of patients with PJS
timeFrame: 1year
Other outcomes:
measure: The association of STK11 with intestinal microbiota of patients with PJS
timeFrame: 1 year
Locations:
city: Shanghai
country: China
facility: Changhai Hospital
Study officials:
affiliation: Changhai Hospital
name: Yiqi Du, Ph.D.
role: STUDY_CHAIR
References:
Clinical trial NCT02184975: Cold Knife Conization With and Without Lateral Hemostatic Sutures
Official title: Randomized Clinical Trial Comparing Cold Knife Conization of the Cervix With and Without Lateral Hemostatic Sutures
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE2
Conditions: Cervical Intraepithelial Neoplasia
Cervix Neoplasms
Keywords: cold knife conization
lateral hemostatic sutures
cervix
Lead sponsor: Barretos Cancer Hospital
Sponsor class: OTHER
First posted: 2014-07-09
Enrollment: 100
Sex: FEMALE
Minimum age (years): 15
Maximum age (years): 80
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The treatment of high grade Cervical Intraepithelial Neoplasia (CIN) 2, 3 is defined according to the colposcopic evaluation of the patient. In case colposcopy findings are satisfactory (visible squamocolumnar junction), both ablative and excisional methods are adequate. In the middle of the 20th century, lateral hemostatic sutures were added to the cold knife conization surgical technique to reduce blood loss. Some authors recommend that these branches should be ligated, but it remains unclear whether these sutures are actually effective in reducing bleeding.This study compared blood loss during cold knife conization of the cervix with and without lateral hemostatic sutures.

Detailed description: This is a study that will evaluate two groups of patients undergoing cold-knife conization for cervical intraepithelial neoplasia high grade where 50% will undergo hemostatic sutures in the lateral cervical and 50% of patients will not be subjected to these sutures. The main objective of the study is to evaluate the amount of intraoperative bleeding.

Eligibility criteria: Inclusion Criteria:

* indication of cold knife conization

Exclusion Criteria:

* conization using techniques other than the cold knife;
* previous cervical conization using any other technique;
* previous pelvic radiotherapy;
* pregnancy; and
* refusal to participate in the study

Primary outcomes:
measure: Intraoperatory vaginal bleeding
timeFrame: Intraoperatory
Secondary outcomes:
Other outcomes:
Locations:
city: Porto Alegre
country: Brazil
facility: Hospital de Clinicas de Porto Alegre
state: RS
Study officials:
affiliation: Hospital de Clinicas de Porto Alegre-Brazil
name: Ricardo D Reis, MD
role: STUDY_CHAIR
References:
citation: Bueno LR, Binda M, Monego H, Scherer RL, Rolim KM, Bottini AL, Fregnani JH, dos Reis R. Randomized clinical trial comparing cold knife conization of the cervix with and without lateral hemostatic sutures. Int J Surg. 2015 Jun;18:224-9. doi: 10.1016/j.ijsu.2015.04.081. Epub 2015 Apr 30.
Clinical trial NCT01052259: Efficacy and Safety of Deoxyspergualin in Renal Transplant Patient With Chronic Rejection
Official title: Pilot Study of Cycling Treatment of Deoxyspergualin in Biopsy-proven Chronic Rejection of Kidney Transplantation
Study type: INTERVENTIONAL
Overall status: TERMINATED
Phase: NA
Conditions: Chronic Rejection
Keywords: Chronic rejection
Kidney
Transplantation
Immunosuppressive
Lead sponsor: Nippon Kayaku Co., Ltd.
Sponsor class: INDUSTRY
First posted: 2010-01-20
Enrollment: 35
Sex: ALL
Minimum age (years): 11
Maximum age (years): 70
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: TREATMENT

Brief summary: The purpose of this study to examine the efficacy and safety of cycling treatment of deoxyspergualin in renal transplant patients with biopsy-proven chronic rejection.

Detailed description: The primary aim of this study is to investigate the efficacy of deoxyspergualin after the completion of 6 cycles treatment. The efficacy valuables are histological findings in renal grafts, renal function, proteinuria, graft survival, anti-HLA antibody. The safety data are also evaluated in the study.

Eligibility criteria: Inclusion Criteria:

* Chronic rejection defined by Banff 2007 criteria

Exclusion Criteria:

* Patients who have recurrent renal diseases and virus-associated renal diseases
* Patients who have initial WBC \< 4,000, neutrophil \< 1,000 , platelet \< 50,000 or Hb \< 8g
* Patients who have acute or chronic infection

Primary outcomes:
measure: Histopathological findings by Banff criteria
timeFrame: 6 month after treatment initiation
Secondary outcomes:
measure: Renal function, proteinuria, graft survival, anti-HLA antibody, adverse events, serious adverse events (SAE)
timeFrame: 6 and 12 months after treatment initiation
Other outcomes:
Locations:
city: Sapporo
country: Japan
facility: Sapporo City General Hospital
state: Hokkaido
city: Suita
country: Japan
facility: Osaka University Graduate School of Medicine
state: Osaka
city: Toda
country: Japan
facility: Toda Central General Hospital
state: Saitama
city: Ota-ku
country: Japan
facility: Toho University Graduate School of Medicine
state: Tokyo
city: Shinjuku-ku
country: Japan
facility: Tokyo Women's Medical University
state: Tokyo
city: Akita
country: Japan
facility: Akita University School of Medicine
city: Fukuoka
country: Japan
facility: Graduate School of Medicine Sciences, Kyushu University
city: Gifu
country: Japan
facility: Gifu University Graduate School of Medicine
Study officials:
affiliation: Sapporo City General Hospital
name: Hiroshi Harada, Chief
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT01739959: Exploratory Study of Raised Serum Lactate as a Marker of Necrotizing Fasciitis
Official title: Raised Serum Lactate as a Marker of Necrotizing Fasciitis; a Consecutive Prospective Review.
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Fasciitis, Necrotizing
Keywords: Necrotizing fasciitis
Fournier's gangrene
Cellulitis
Serum Lactate
Lead sponsor: National Health Service, United Kingdom
Sponsor class: OTHER_GOV
First posted: 2012-12-04
Enrollment: 53
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: All patients referred to a single surgeon at one institution over 10 years (September 2000 - September 2010) with a suspected diagnosis of necrotizing fasciitis. Patients were followed for the duration of their hospital stay.

Brief summary: The investigators examined the hypothesis that serum lactate is raised in early necrotizing fasciitis to a much greater extent than in other differential diagnoses, such as severe cellulitis, and therefore provides a diagnostic indicator.

Detailed description: A prospective comparison of serum lactate levels at referral to the Plastic Surgery team to the 'gold standard' test of histology at initial surgical debridement, looking at 53 consecutive patients referred with suspected necrotizing fasciitis to a single surgeon at one institution between 2000 and 2010.

Eligibility criteria: Inclusion Criteria:

* Referral to one consultant (Mr A Armstrong) at one institution (Wexham Park Hospital) with a suspected diagnosis of necrotizing fasciitis between September 2000 and September 2010

Exclusion Criteria:

* Nil

Primary outcomes:
measure: Serum lactate level
timeFrame: At referral to the Plastic Surgery Team
Secondary outcomes:
Other outcomes:
Locations:
city: Slough
country: United Kingdom
facility: Wexham Park Hospital
state: London
Study officials:
affiliation: Wexham Park Hospital
name: George Murphy, MRCS
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT03848559: Airway Management With Simulated Microgravity Using a Submerged Model
Official title: Airway Management With Simulated Microgravity Using a Submerged Model
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Airway Management
Emergency Medicine
Lead sponsor: Universitätsklinikum Köln
Sponsor class: OTHER
First posted: 2019-02-20
Enrollment: 40
Sex: ALL
Minimum age (years): 18
Maximum age (years): 65
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Intervention model: SEQUENTIAL
Primary purpose: OTHER

Brief summary: Trained anesthesiologist- or emergency physician-divers will perform an airway management in simulated microgravity on a submerged model.

Detailed description: Trained anesthesiologist- or emergency physician-divers participate in the study. Simulated microgravity during spaceflight is obtained by using a submerged model. Full-torso manikins is going to be used for performing airway management. Each diver attempted airway management with each device (laryngeal mask, laryngeal tube, orotracheal intubation with video-assisted laryngoscope. The time for airway protection will be measured as well as the success rate.

Eligibility criteria: Inclusion Criteria:

* Anaesthesiologist with diver licence or Emergency physician with diver license

Exclusion Criteria:

* All other

Primary outcomes:
measure: Number of inserts
timeFrame: after 5 minutes
measure: Time to first ventilation
timeFrame: after 5 minutes
Secondary outcomes:
Other outcomes:
Locations:
city: Cologne
country: Germany
facility: University Hospital of Cologne
state: NRW
Study officials:
affiliation: UK Köln
name: Jochen Hinkelbein, MD, PhD
role: STUDY_CHAIR
References:
Clinical trial NCT06326359: Autologous Stromal Vascular Fraction in Treatment of Male Androgenic Alopecia
Official title: Evaluation of Safety and Efficacy of Autologous Stromal Vascular Fraction Derived From Denovo Versus Platelet Rich Plasma Enhanced Donner Site in Treatment of Male Androgenic Alopecia
Study type: INTERVENTIONAL
Overall status: NOT_YET_RECRUITING
Phase: NA
Conditions: Androgenic Alopecia
Keywords: autologous stromal vascular fraction
platelet rich plasma
male androgenic alopecia
Lead sponsor: Sohag University
Sponsor class: OTHER
First posted: 2024-03-22
Enrollment: 40
Sex: MALE
Minimum age (years): 18
Maximum age (years): 55
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: Evaluation of Safety and efficacy of autologous stromal vascular fraction derived from denovo versus platelet rich plasma enhanced donner site in treatment of male androgenic alopecia

Detailed description: 40 Patients with androgenic alopecia will be randomly divided into 2 groups Group A (20): will receive 2 session of stromal vascular fraction directly after fat harvesting and processing and stromal vascular fraction extraction with 1 month interval .

Group B(20): will be injected with 2 session of Platelet rich plasma 3weeks interval at site of fat harvesting and will be followed 1 month later with fat aspiration from site where Platelet rich plasma was previously injected and this fat will undergo fat processing and stromal vascular fraction extraction followed by 2 session of stromal vascular fraction injection at scalp 1month interval .

Patients at both groups will receive topical and systemic antibiotics after stromal vascular fraction injection .

Eligibility criteria: Inclusion Criteria:

* Male patients with androgenic alopecia

Exclusion Criteria:

* Patients with other hair loss disorders as telogen effluvium, anagen effluvium, alopecia areata, cicatricial alopecia and trichotillomania.

Any other cutaneous disease as patients suffering from dermatological condition or a significant scarring in the treatment area.

Any systemic disease as autoimmune disorders , cardiac hepatic and renal patients.

patients who received minoxidil or any other oral, topical medications (including herbal medications) or injection procedures for the treatment of hair loss within 6 months prior to the study, or finasteride or dutasteride within 12 months of the study

Primary outcomes:
measure: hair density
timeFrame: at baseline and at 6 month after treatment
measure: hair shaft thickness
timeFrame: at baseline and at 6 month after treatment
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
References:
Clinical trial NCT00306059: Early Goal Directed Therapy for Acute Kidney Injury
Official title: Early Goal Directed Therapy for Acute Kidney Injury
Study type: INTERVENTIONAL
Overall status: WITHDRAWN
Phase: PHASE2
Conditions: Kidney Injury, Acute
Lead sponsor: University Hospital, Ghent
Sponsor class: OTHER
First posted: 2006-03-22
Enrollment: 0
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: Early goal directed therapy during 6 hours after occurence of the early phase of acute kidney injury


Eligibility criteria: Inclusion Criteria:

* over 18 years old
* occurence of the early phase of acute kidney injury
* stay on intensive care unit

Exclusion Criteria:

* chronic haemodialysis
* not given informed consent

Primary outcomes:
measure: Observation of acute kidney injury
timeFrame: after 48 hours
Secondary outcomes:
measure: Organ failure during first 48 hours and during stay on intensive care unit
timeFrame: after 48 hours
measure: Duration of stay on intensive care unit and in hospital
timeFrame: t0
measure: Mortality during stay on intensive care unit
timeFrame: after 28 days, 60 days and during stay in hospital
Other outcomes:
Locations:
city: Ghent
country: Belgium
facility: University Hospital Ghent
Study officials:
affiliation: University Hospital, Ghent
name: Eric Hoste, MD, PhD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT04871659: Attitudes Behavior and Practices of Mothering Among an Online Panel
Official title: Attitudes Behavior and Practices of Mothering Among an Online Panel
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Tantrum
Relation, Family
Parent-Child Relations
Parenting
Keywords: MTurk
Lead sponsor: Columbia University
Sponsor class: OTHER
Collaborators: name: Einhorn Family Charitable Trust
First posted: 2021-05-04
Enrollment: 374
Sex: FEMALE
Minimum age (years): 18
Maximum age (years): 55
Standard ages: ADULT
Observational model: COHORT
Time perspective: CROSS_SECTIONAL
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Biological mothers of children between ages 0-5 living in the US who are users of Amazon's mTurk platform

Brief summary: Subjects are users on Amazon's Mechanical Turk (MTurk) platform. MTurk users will be asked to complete a screening survey about family structure. The purpose of the screening survey is to identify MTurk users who are biological mothers of children aged 1.5 to 6 years old, and to collect survey information on how mothers interact with their children, with the aim of better understanding family relationships.

Detailed description: This is a feasibility study that aims to identify a panel of biological mothers of children aged 1.5 to 6 years old from an online pool of participants on Amazon's Mechanical Turk (MTurk; www.mturk.com). MTurk is a novel method to recruit participants from online behavioral studies. Although MTurk workers are anonymous, demographic surveys from previous studies conducted on the web platform indicate that the majority of MTurk users are females living in the U.S. The participant pool may be of scientific interest in pursuing studies that investigate patterns of behaviors and other information pertaining to mothers. A panel of mothers that fit screening criteria may be helpful for future planned studies on attitudes, behavior, and practices surrounding mothering. The MTurk mothers panel will be eligible to participate in future studies involving knowledge, attitudes, and practices of their motherhood and of emotional connection with their children.

Eligibility criteria: Inclusion Criteria:

* Biological mothers of children between ages 1.5-6 living in the US

Exclusion Criteria:

* Not having reliable internet access

Primary outcomes:
measure: Correlations between survey items
timeFrame: Day 1
Secondary outcomes:
Other outcomes:
Locations:
city: New York
country: United States
facility: Columbia University Irving Medical Center
state: New York
Study officials:
affiliation: Columbia University
name: Martha G. Welch, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT03085459: Effects of Nursing Staff on Empiric Antibiotic in Septic Shock
Official title: The Effect of Nursing Staff on Empiric Antibiotic Treatment Within the First Hour in Patients With Septic Shock: A Retrospective Study
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Septic Shock
Compliance
Antibiotic
Nursing Caries
Lead sponsor: Southeast University, China
Sponsor class: OTHER
First posted: 2017-03-21
Enrollment: 214
Sex: ALL
Minimum age (years): 18
Maximum age (years): 80
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: RETROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: All adult patients whose age of 18 years or older admitted to the ICU with septic shock from between January 01, 2015 to February 29, 2016

Brief summary: A retrospective, observational study was performed about the patients with septic shock who admitted into intensive care unit (ICU) from January 1, 2015 to February 29, 2016. The number of patients who received empiric antibiotic treatment within first hour after septic shock diagnosis were collected. Detailed information about clinical ladder for nursing stuff and nursing shift were collected . Clinical ladder for nursing stuff is a new definition based on education background and work experience and nurses stuff are classified into four levels. N0 was defined who got college degree or above, nurse qualification certificate and working time less than one year. N1 an N2 were defined as who got nurse qualification certificate and working time between 1\~3 years and more than three years, respectively. N3 was defined who was nurse-in-charge qualification or got nurse practitioner qualification for more than five years. Compliance of empiric antibiotic treatment within first hour and evaluate the effect of nursing stuff on the compliance were calculated.


Eligibility criteria: Inclusion Criteria:

* age\>18 years old
* sepsis

Exclusion Criteria:

* pregnancy
* \>80 years old.

Primary outcomes:
measure: compliance of empiric antibiotic treatment within first hour
timeFrame: 1 hour
measure: evaluate the effect of nursing stuff on the compliance
timeFrame: 1 hour
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
References: