Clinical trial NCT04411485: Sexual Dysfunction in Partner of Patients With Ankylosing Spondylitis
Official title: Evaluation of Sexual Satisfaction and Sexual Dysfunction in Partner of Patients With Ankylosing Spondylitis
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Ankylosing Spondylitis
Sexual Dysfunction
Keywords: Ankylosing spondylitis
sexual dysfunction
Lead sponsor: Antalya Training and Research Hospital
Sponsor class: OTHER_GOV
First posted: 2020-06-02
Enrollment: 80
Sex: ALL
Minimum age (years): 18
Maximum age (years): 65
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: CASE_CONTROL
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: Patients with ankylosing spondylitis diagnosed by the rheumatologist

Brief summary: The adverse effects of rheumatologic diseases, especially Ankylosing Spondylitis (AS), on sexual functions are known. The causes of sexual dysfunction in rheumatologic diseases are due to factors such as pain, weakness, fatigue, stiffness, functional disability, anxiety, depression, hormonal deficiency, drug use, decreased libido and poor body image. Depending on these factors, sexual intercourse and frequency of sexual intercourse may decrease. Sexual dysfunction may be seen in AS due to physical and emotional problems caused by the disease.

Detailed description: There are many studies in the literature that determine sexual satisfaction and sexual dysfunction in individuals with AS and compare individuals with AS to healthy individuals . In the light of these studies, the investigators thought that the sexual function of partner of individuals with AS may also be affected negatively. In the literature, no previous study examines the sexual function of partner of individuals with AS. Therefore, the aim was to determine the sexual function of partner of individuals with AS and to compare with healthly adults of the same sex.

Eligibility criteria: Inclusion Criteria:

* Being diagnosed with AS for individuals with AS,
* No additional disease (comorbid and psychiatric disease, hypothyroidism, hypopituitarism, hypogonadism or hyperprolactinemia)
* Having a partner (relationship status in a monogamous sexual relationship),
* Not smoking and drinking,
* Non-AS partner have not been diagnosed with AS and their partner is AS.

Exclusion Criteria:

* Overweight or obesity (BMI \<28 kg / m2)
* Having had a pelvic injury, urological or gynecological operation in the last 3 months
* Hypogonadism; penile abnormalities such as hypospadias, congenital curvature or Peyronie's disease with preserved penis stiffness
* Prostatic disorder
* Use of drugs that may affect erectile function (steroids, antihistamines, ß-blockers or SSRIs)

Primary outcomes:
measure: Female Sexual Function Scale
timeFrame: 1 week
measure: International Erectile Function Form
timeFrame: 1 week
Secondary outcomes:
Other outcomes:
Locations:
city: Antalya
country: Turkey
facility: Antalya Tarining and Research Hospital Ethics Commitee
Study officials:
affiliation: Antalya Training and Research Hospital
name: Ayse Ayan, MD
role: PRINCIPAL_INVESTIGATOR
References:
citation: Liu YF, Dong H, Chen Z, Wang YU, Tu SH. Impact of ankylosing spondylitis on sexual function: A systematic review and meta-analysis. Exp Ther Med. 2015 Apr;9(4):1501-1507. doi: 10.3892/etm.2015.2239. Epub 2015 Jan 29.