Clinical trial NCT05382065: Anemia and Duration of Mechanical Ventilation
Official title: The Correlation Between Period of Anemia and Duration of Mechanical Ventilation in Patients Admitted to the Surgical Intensive Care Unit
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Anemia
Mechanical Ventilation
Critically Ill
Intensive Care Unit
Morality
Organ Dysfunction Syndrome
Keywords: Duration of mechanical ventilation
Duration of anemia
Intensive care unit
Mortality
Organ dysfunction
Lead sponsor: Mahidol University
Sponsor class: OTHER
First posted: 2022-05-19
Enrollment: 250
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: RETROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Adult patients admitted to the surgical intensive care unit and required ventilatory support with invasive mechanical ventilation for more than 96 hours

Brief summary: In mechanically ventilated patients in intensive care unit, anemia is commonly seen and it is probably associated with adverse outcomes including mortality. We aim to investigate the impact of duration of anemia and the duration of mechanical ventilation as well as clinical outcomes in critically ill patients in intensive care unit who required ventilatory support \>96 hr.

Detailed description: Anemia is one of the most common conditions encountered critically ill patients. Various mechanisms can put these patients at risk of anemia including gastrointestinal hemorrhage, iron deficiency, inflammation and infection, stress, and multiple blood testing. Anemia can affect cardiopulmonary function as depletion in oxygen content in body. In mechanically ventilated patients, anemia is associated with increased duration of mechanical ventilation, increased length of stay, and possibly increased mortality. Some research suggested that hemoglobin level \<8.5 g/dl was a potential risk factor for adverse outcome in critically ill patients required mechanical ventilation \>96 hr. However, most researches focused on hemoglobin levels and the associated adverse events in mechanically ventilated patients. To the best of our knowledge, there are few studies reported the impact of the duration of anemia and the clinical outcomes in these patients. We hypothesize that the short duration of anemia developed in mechanically ventilated patients has no effect on duration of mechanical ventilation. We, therefore, aim to investigate the impact of the duration of anemia on duration of mechanical ventilation in critically ill patients required ventilatory support \>96 hours.

Eligibility criteria: Inclusion Criteria:

* Patients whose age of equal or more than 18 years old
* Patients admitted to the surgical intensive care unit during the study period
* Patients required ventilatory support with invasive mechanical ventilation for more than 96 hours

Exclusion Criteria:

* Patients whose data regarding time of beginning or ending of ventilatory support missed
* Patients who are previously included in this study and are re-admitted

Primary outcomes:
measure: Duration of mechanical ventilation
timeFrame: 28 days after initiation of ventilatory support
Secondary outcomes:
measure: Duration of anemia
timeFrame: 28 days after initiation of ventilatory support
measure: Cardiovascular dysfunction
timeFrame: 28 days after initiation of ventilatory support
measure: Respiratory dysfunction
timeFrame: 28 days after initiation of ventilatory support
measure: Renal dysfunction
timeFrame: 28 days after initiation of ventilatory support
measure: Gastrointestinal dysfunction
timeFrame: 28 days after initiation of ventilatory support
measure: Hematologic dysfunction
timeFrame: 28 days after initiation of ventilatory support
measure: ICU length of stay
timeFrame: Up to 90 days following inclusion
measure: Hospital length of stay
timeFrame: Up to 90 days following inclusion
measure: ICU mortality
timeFrame: Up to 90 days following inclusion
measure: Hospital mortality
timeFrame: Up to 90 days following inclusion
Other outcomes:
Locations:
city: Bangkok Noi
country: Thailand
facility: Department of Anesthesiology, Faculty of Medicine Siriraj Hospital, Mahidol University
state: Bangkok
Study officials:
affiliation: Department of Anesthesiology, Faculty of Medicine Siriraj Hospital, Mahidol University
name: Annop Piriyapatsom, MD
role: PRINCIPAL_INVESTIGATOR
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