Clinical trial NCT05171686: Diuretics and Volume Overload in Early CKD
Official title: Association of Diuretics With Change in Extracellular Volume, Natriuretic Peptides, Symptoms, and Cardiovascular Outcomes in CKD
Study type: INTERVENTIONAL
Overall status: RECRUITING
Phase: PHASE4
Conditions: Chronic Kidney Disease
Hypertension
Keywords: diuretic
chronic kidney disease
hypertension
extracellular volume
natriuretic peptides
Lead sponsor: VA Office of Research and Development
Sponsor class: FED
First posted: 2021-12-29
Enrollment: 46
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Intervention model description: Open label single arm clinical trial
Primary purpose: TREATMENT

Brief summary: Almost 15% of Americans have chronic kidney disease (CKD), with an even higher rate in Veterans due to common risk factors such as high blood pressure and diabetes. People with CKD have a high risk of cardiovascular (CV) diseases, such as heart attacks, heart failure, and strokes. Extra fluid in the body, called volume overload, may lead to CV disease in people with CKD. It is unknown if volume overload develops in the earliest stages of CKD, when treating it with common, inexpensive medicines called diuretics may improve long-term CV outcomes. This study will lay important groundwork to answer this question in Veterans with early CKD by comparing two ways to measure volume overload and studying the change in common symptoms like fatigue and short-term CV function after treatment with diuretic medicines.

Detailed description: The investigators previously showed that brain natriuretic peptide (BNP) and N-terminal-pro-BNP (NT-pro-BNP), measures of ventricular stretch, are associated with death and cardiovascular (CV) outcomes in patients with chronic kidney disease (CKD) stages 1-3, and the investigators' preliminary pilot results suggest that these natriuretic peptides may correlate with objective measures of excess extracellular volume (ECV) and with symptoms common in CKD. The overarching objective is to determine if initiation of diuretic treatment or increase in dose is associated with changes in BNP and NT-pro-BNP, patient-reported symptom burden, and short-term hemodynamic parameters in patients with CKD stages 1-3 and elevated blood pressure, and whether these changes correlate with changes in ECV. The central hypothesis is that the change in ECV after starting or increasing diuretics in Veterans with stages 1-3 CKD is associated with changes in 1) natriuretic peptides, 2) patient-level factors, and 3) CV physiology.

The investigators will compare the changes in natriuretic peptides, symptoms, and CV parameters with the change in ECV after diuretic initiation or dose increase. The primary aim is to determine if initiation of diuretic treatment or increase in diuretic dose is associated with changes in natriuretic peptides. Secondary aims are to determine the effect of diuretic change on patient-reported symptom burden, and CV physiology.

This clinical trial will include 46 outpatients with CKD stages 1-3 and blood pressure \>140/90 mmHg. At the first visit, the investigators will initiate or increase the dose of a thiazide or loop diuretic. Study measures other than echocardiogram will be repeated 4 weeks after the intervention to determine changes in these parameters. ECV will be measured by whole-body multifrequency bioimpedance spectroscopy (BIS), which is a validated, non-invasive, painless measure of ECV. Plasma BNP and NT-pro-BNP will be measured, and patient-reported fatigue, depression, and quality of life will be quantified using validated questionnaires. Hemodynamic parameters include blood pressure, pulse pressure, and total peripheral resistance index (TPRI) and cardiac index measured by Non-Invasive Hemodynamic Monitoring. A transthoracic echocardiogram will measure left ventricular mass index, valvular disease, and diastolic dysfunction.

Variables will be compared within participants between baseline and Visit 2 using paired Wilcoxon Signed Rank tests or paired Student's t tests, depending on variable distributions. Correlations between change in ECV/total body weight and all continuous outcome measures will be analyzed using Spearman or Pearson correlations, applying appropriate transformations. Linear regression analysis will control for clinically relevant variables. The relationship between ECV/total body weight and natriuretic peptides from both visits will be evaluated using a mixed effects model to account for the change in these measures between baseline and Visit 2.

Eligibility criteria: Inclusion Criteria:

* Male or female Veterans age 18 years or older. There will be no upper age limit.
* The presence of CKD stages 1, 2, or 3, as defined below by Kidney Disease Improving Global Outcomes guidelines, for a period of at least 3 months.

  * Stage 1: eGFR 90 mL/min/1.73 m2 and spot urine albumin-to-creatinine ratio 30 mg/g.
  * Stage 2: eGFR 60-89 mL/min/1.73 m2 and spot urine albumin-to-creatinine ratio 30 mg/g.
  * Stage 3: eGFR 30-59 mL/min/1.73 m2.
* Measured blood pressure either \>140 mmHg systolic or \>90 mmHg diastolic at the two most recent clinic visits.
* Able to understand and sign informed consent after the nature of the study has been fully explained.

Exclusion Criteria:

* Unable to understand or provide informed consent.
* Unwilling or unable to participate in the protocol or comply with any of its components.
* CKD stages 4-5, defined as eGFR \<30 mL/min/1.73 m2.
* Receiving chronic hemodialysis or peritoneal dialysis.
* Recipient of a kidney transplant.
* Serum potassium \<3.5 mEq/L at baseline.
* Known left ventricular ejection fraction \<40% on visual estimate based on chart review of available echocardiogram data.
* Known hepatic cirrhosis.
* Major limb amputation.
* Known pregnancy.
* Presence of a pacemaker or defibrillator.

Primary outcomes:
measure: Change in NT-pro-BNP
timeFrame: 4 weeks
Secondary outcomes:
measure: Change in BNP
timeFrame: 4 weeks
measure: Change in FACIT-F score
timeFrame: 4 weeks
measure: Change in QIDS-SR16
timeFrame: 4 weeks
measure: Change in KDQOL
timeFrame: 4 weeks
measure: Change in total peripheral resistance index
timeFrame: 4 weeks
measure: Change in systolic blood pressure
timeFrame: 4 weeks
measure: Change in diastolic blood pressure
timeFrame: 4 weeks
measure: Change in mean arterial pressure
timeFrame: 4 weeks
measure: Change in pulse pressure
timeFrame: 4 weeks
measure: Change in cardiac index
timeFrame: 4 weeks
measure: Change in extracellular volume normalized/total body weight
timeFrame: 4 weeks
Other outcomes:
Locations:
city: Houston
country: United States
facility: Michael E. DeBakey VA Medical Center, Houston, TX
state: Texas
Study officials:
affiliation: Michael E. DeBakey VA Medical Center, Houston, TX
name: Lucile P Gregg, MD MS
role: PRINCIPAL_INVESTIGATOR
References: