Clinical trial NCT02791139: Association of Midlife Dietary and Lifestyle Factors on Cardiac Functional Changes in the Elderly
Official title: Association of Midlife Dietary and Lifestyle Factors on Cardiac Functional Changes in the Elderly
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Ageing
Lead sponsor: National Heart Centre Singapore
Sponsor class: OTHER
Collaborators: name: National University of Singapore
First posted: 2016-06-06
Enrollment: 800
Sex: ALL
Minimum age (years): 60
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: CASE_CONTROL
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: 600 ageing participants randomly chosen from a current pool of about 5290 surviving cohort participants in the Singapore Chinese Health Study will be recruited.

200 Healthy Volunteers control group

Brief summary: The investigators aim to investigate the association of midlife dietary and lifestyle factors on cardiac functional changes in the elderly. The investigators hypothesize that even in those without clinically manifest cardiovascular disease, the extent of underlying abnormalities in cardiovascular structure and function in the elderly would be independently related to midlife dietary and lifestyle factors.

Detailed description: This proposal will investigate how midlife factors in diet and lifestyle affect various aspects of cardiac structure and function related to ageing. The investigators plan to conduct the study among a sub-cohort of 600 participants from the Singapore Chinese Health Study. Comprehensive information on diet and lifestyle factors had been collected at recruitment and updated in two subsequent follow-up interviews. Candidate nutrition-related blood biomarkers such as vitamins D, homocysteine, fatty acids (short, medium and long-chain) and lipids (LDL, HDL, triglycerides) will be analyzed from samples obtained between 1999 and 2004. The investigators will study effects of smoking, alcohol consumption, sleep duration, physical activity and diet on cardiac ageing. The investigators will study overall dietary pattern, intake of specific items such as fatty acids, soy food, coffee and tea beverages, from validated food frequency questionnaires (FFQ), and nutrients from questionnaire information from this cohort previously obtained.

These nutrient and lifestyle factors will be studied individually, and for their joint or interactive effects on cardiac ageing measurements. Quantitative cardiac ageing-related outcome parameters describing cardiac mass, systolic and diastolic function, and vessel distensibility will be examined by cardiac magnetic resonance imaging. Maximum oxygen uptake (VO2 max) will be calculated based on age, gender, waist circumference, resting heart rate, and exercise habits. Body composition will be analysed by a body composition analyser machine onto which subjects stand on.

Eligibility criteria: Inclusion Criteria:

* Who were younger than 60 years at recruitment
* Had been interviewed at baseline and at the two follow-up interviews
* Had provided biospecimens for research previously before the age of 65 years (2000-2004)
* Who will be 65 years or older by 2013

Exclusion Criteria:

* Any known history of heart disease or stroke
* Anticipated life expectancy \< 1 year
* Unable to provide written informed consent to participate in the study
* Patients with cancer
* Patients with chronic renal disease
* Any metallic implants

Primary outcomes:
measure: First occurrence of cardiovascular event
timeFrame: 1 Year
Secondary outcomes:
Other outcomes:
Locations:
city: Singapore
country: Singapore
facility: National Heart Centre Singapore
Study officials:
affiliation: National Heart Centre Singapore
name: Su-Mei Angela Koh, MBBS
role: PRINCIPAL_INVESTIGATOR
References:
citation: Tan YH, Lim JP, Lim WS, Gao F, Teo LLY, Ewe SH, Keng BMH, Tan RS, Koh WP, Koh AS. Obesity in Older Adults and Associations with Cardiovascular Structure and Function. Obes Facts. 2022;15(3):336-343. doi: 10.1159/000521729. Epub 2022 Mar 4.
citation: Kovalik JP, Zhao X, Gao F, Leng S, Chow V, Chew H, Teo LLY, Tan RS, Ewe SH, Tan HC, Wee HN, Lee LS, Ching J, Keng BMH, Koh WP, Zhong L, Koh AS. Amino acid differences between diabetic older adults and non-diabetic older adults and their associations with cardiovascular function. J Mol Cell Cardiol. 2021 Sep;158:63-71. doi: 10.1016/j.yjmcc.2021.05.009. Epub 2021 May 24.
citation: Koh AS, Velmurugan B, Gao F, Tan RS, Wong JI, Teo LLY, Keng BMH, Chua SJM, Yuan JM, Koh WP, Cheung C. Value of soluble Urokinase plasminogen activator receptor over age as a biomarker of impaired myocardial relaxation. BMC Geriatr. 2017 Nov 28;17(1):275. doi: 10.1186/s12877-017-0668-0.