Clinical trial NCT06652815: Cognition, Metacognition, and Stigma in Patients With Suicidal Ideation
Official title: Cognition, Metacognition, and Stigma in Patients With Suicidal Ideation
Study type: OBSERVATIONAL
Overall status: NOT_YET_RECRUITING
Conditions: Persons With High Suicide Ideation or Attempts
Keywords: Suicide attempt
Metacognition
suicide ideation
Executive function
Lead sponsor: University of Pittsburgh
Sponsor class: OTHER
Collaborators: name: Fogarty International Center of the National Institute of Health
First posted: 2024-10-22
Enrollment: 212
Sex: ALL
Minimum age (years): 18
Maximum age (years): 60
Standard ages: ADULT
Accepts healthy volunteers: no
Observational model: CASE_ONLY
Time perspective: CROSS_SECTIONAL
Sampling method: NON_PROBABILITY_SAMPLE
Study population: The present study is a cross sectional study. For the purpose of this study, individuals with suicidal ideation and attempts who are seeking treatment at the outpatient department of Psychiatry, as well as medical emergency of Dr. RML Hospital or referred to Department of Clinical Psychology would be approached to participate in the study.

Brief summary: Deficits of executive function, meta cognition and stigma is known in suicidal ideation; however, their relationship is unknown. Since many studies use a single indicator of executive function and, it was considered important to study. Metacognition, executive functioning and stigma are the possible driving force behind the suicidal behavior in human being. With respect to research in the Indian context, there is paucity of studies exploring these factors. The purpose of the present study is to explore the relationships between executive functioning, metacognition, and stigma in suicidal ideation and suicide attempters in the Indian setup, where there is a lacuna in research regarding the same. Having a detailed understanding of these psychological parameters will be helpful in suicide prevention and management.

Detailed description: Worldwide 10 to 20 million individuals attempt suicide every year. The suicide rate in India is 10.3. In the last three decades, the suicide rate has increased by 43% but the male female ratio has been stable at 1.4: 1. Majority (71%) of suicide in India are by persons below the age of 44 years which imposes a huge social, emotional and economic burden. Those having suicide ideas, about one third of them act with a suicide attempt, and 60% of these transitions occur within the first year after onset of suicidal thoughts.

Executive functioning and Suicide Studies reported that deficits in some executive functions are correlated with an elevated risk for suicide attempts. Executive dysfunction may interfere with an individual's ability to understand that they are at risk for suicide as well as with their ability to cope with that risk. Although past studies have identified the role of cognitive factors in suicide, little has been done to explore the cognitive processes involved in suicidal thinking in adults (Ong et al. 2016). Neuropsychological alterations can lead to inaccurate perception, interpretation, and response to environmental information, which could be a risk factor for suicide (Fernández-Sevillano et al. 2021).

Metacognition is an essential process regarding decision making and coping with stressful life events. It describes the awareness of person's cognitions in relation to suicide (thoughts, beliefs and attributions). The suicidal person feels helpless and decides that death is only solution. The person has narrowed all his/her options solely to death. Knowing these patterns will give some guidance in talking to a suicidal person. It is significant for assessing to try to accept and understand feelings "meta-emotion" and thought/attributions "meta-cognition" the person is expressing (Abdulla et al. 2018).

Stigma is most often defined as a mark of disgrace or infamy; a stain or reproach, as on one's reputation. In suicide investigators talk about public and self-stigma. Both forms of stigma can separately cause social isolation, demoralization, hopelessness and other consequences that interfere with the previous functioning. Because of the high incidence of psychological changes after stigma it is crucial for the bereaved to have close mental health services. But stigma is a barrier to treatment seeking. After suicide attempt most survivors feel stigmatized but it is not yet known which factors modify the perception of stigma (Sabina et al. 2017).

The purpose of the present study is to explore the relationships between executive functioning metacognition, and stigma in suicidal ideation and suicide attempters in the Indian setup, where there is a lacuna in research regarding the same.

Research questions

* What is the executive functioning, metacognitive beliefs, and stigma in persons with high suicide ideation or attempts?
* Is there any relationship among executive functioning, metacognitive beliefs, and stigma in these individuals? Hypotheses There will be a relationship among executive functioning, metacognitive beliefs, and stigma in persons with high suicide ideation or attempts.

Objective To assess the executive functioning, metacognitive beliefs, and stigma in persons with high suicide ideation or attempts.

To study the relationship among executive functioning, metacognitive beliefs, and stigma in persons with high suicide ideation or attempts.

Methodology Samples size: Total number of sample for this study will be N=212. The sample size 212 was calculated on the basis of estimated population of 1000 using Epitools online sample size calculator (https://epitools.ausvet.com.au/oneproportion) , and Confidence level was 0.95, with Desired precision of estimate=0.05.

Sampling: Probability sampling (Simple random sampling (Every Individual with high suicide ideation or suicide attempts visiting to ABVIMS -Dr. RML Hospital for treatment will be screened for this study.

The present study is a cross sectional study. For the purpose of this study, individuals with suicidal ideation and attempts who are seeking treatment at the outpatient department of Psychiatry, as well as medical emergency of Dr. RML Hospital or referred to Department of Clinical Psychology would be approached to participate in the study.

After establishing the rapport, diagnostic clarifications (ICD-10) and screening for high suicide ideation using Beck Scale for Suicidal Ideation (BSSI), inclusion and exclusion criteria will be applied. Participant who fulfils inclusion criteria will be introduced to the study details, then they will be explained about the purpose of the study and its associated aspects and informed consent will be taken. Their socio- demographics details will also be gathered. Following this Depression, Anxiety and Stress Scale (DASS-21), Wisconsin Card Sorting Test (WCST), Metacognitions Scale (MCQ-30) and Stigma of Suicide Scale (SOSS) will be administered.

All the data will be kept confidential in lock and key and using password protected files. Once all the assessment will be completed data entry in excel sheets will be done and analysis of the data will be done using appropriate SPSS statistical package. After all the analysis completed result and discussion of the study will be prepared.

Detail of tools to be used:

1. ICD-10 Research diagnostic criteria
2. Socio-demographic and clinical data sheet
3. Depression, Anxiety and Stress Scale-21 Items (DASS-21)
4. Beck Scale for Suicidal Ideation (BSSI)
5. Wisconsin Card Sorting Test (WCST)
6. Metacognitions Scale (MCQ-3)
7. Stigma of Suicide Scale (SOSS)

Eligibility criteria: Inclusion Criteria:

* Any gender
* Age between 18 to 60 years.
* Able to read and write in Hindi and English
* With a primary mental health diagnosis of anxiety, depression, acute stress reaction or adjustment disorder, or with no diagnosis at all
* Persons with high suicidal ideation (Score 2 or more in first five items of BSSI)
* Person who attempted suicide in last three months.

Exclusion Criteria:

* Any comorbid personality disorder diagnosis
* Diagnosis of a major mental disorder such as Schizophrenia or Bipolar Affective Disorder.
* Intellectual Disability and neurological disorder.

Primary outcomes:
measure: Metacognition measured by Metacognitions Questionnaire (MCQ-3) scores
timeFrame: Within one week
measure: Depression, Anxiety and Stress Scale-21 scores
timeFrame: Within one week
measure: Stigma of Suicide Scale (SOSS) scores
timeFrame: Within one week
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
affiliation: University of Pittburgh
name: Vishwajit L Nimgaonkar, MD, PhD
role: PRINCIPAL_INVESTIGATOR
References: