Clinical trial NCT02076334: Effect of Compression Garments on Exercise Performance Following Acute High Intensity Exercise
Official title: Effect of Compression Garments on Exercise Performance Following Acute High Intensity Exercise
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Muscle Damage
Keywords: compression, isokinetic, far-infrared
Lead sponsor: University of North Carolina, Chapel Hill
Sponsor class: OTHER
Collaborators: name: Rhodia, Inc
First posted: 2014-03-03
Enrollment: 84
Sex: ALL
Minimum age (years): 18
Maximum age (years): 35
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: FACTORIAL
Primary purpose: PREVENTION

Brief summary: To examine the influence of compression garments manufactured with Far-Infrared technology on exercise performance during and after repeated eccentric isokinetic muscle actions of the leg extensors.

Detailed description: Participants: Eighty recreationally active (1-5 hrs per week) healthy participants between the ages of 18 - 35 will visit the Neuromuscular Research Laboratory on 6 separate occasions, with 4 of those occasions also requiring a visit to Health services for a blood draw.

Procedures (methods): During pre-screening, each participant will complete an informed consent document, a health history questionnaire, and have their stature and body mass assessed. A familiarization session will then be conducted on a separate day where all participants will practice the strength assessment, eccentric isokinetic protocol, and ultrasound assessments. Participants will be assigned to 1 of the 4 treatment groups based on their initial maximal isometric strength values using a matched-participants design. The first experimental session will then begin 2-10 days later, where the participants will perform the repeated eccentric exercise protocol (10 sets of 15 eccentric contractions 210 deg/sec with 3 min of rest between sets) with the non-dominant leg following a 60 min rest period where they will wear the apparel and perform a 5 min warm-up on a cycle ergometer. Follow-up blood draws and strength and ultrasound assessments will be obtained at 24 and 48 hours post-exercise. Each participant will also complete a visual analog scale at baseline, 24, 48, and 72 hours post-exercise to examine perceived muscle soreness.

Eligibility criteria: Inclusion Criteria:

* Cohort of Adult Males \& Females
* Participant is between the ages of 18-35
* Healthy, Recreationally Active (1-5 hours per week)
* Participant has provided written and dated informed consent to participate in the study
* Participant is apparently healthy and free from disease, as determined by a health history questionnaire
* Participant agrees to abstain from smoking, caffeine (4hrs prior), tobacco (24hrs prior), and alcohol (24 hrs) before testing days
* Participant agrees to abstain from exercise 24 hours prior to each testing visit and after 72 hours of the induced exercise damage
* Participant will refrain from the use of non-steroidal anti-inflammatory drugs (NSAIDs) and protein supplementation 24 hours before the exercise testing protocol, as well as for the 72 hour period following the exercise testing protocol.

Exclusion Criteria:

* Participant is using, or has used one of the following dietary supplements within 12 weeks prior to enrollment: beta-alanine, creatine, taurine, or any supplemental antioxidants (Acai, pomegranate, beet juice).
* Participant is in, or has participated in another clinical trial within 6 weeks prior to enrollment
* Participant has a known allergy or sensitivity to test product (determined from health history questionnaire and consent form)

Primary outcomes:
measure: Maximal Voluntary Contraction (MVC)
timeFrame: up to 72 hours
Secondary outcomes:
measure: Creatine Kinase
timeFrame: baseline, 24 hrs and 48 hrs post
Other outcomes:
Locations:
city: Chapel Hill
country: United States
facility: Exercise and Sport Science (University of North Carolina)
state: North Carolina
Study officials:
affiliation: University of North Carolina, Chapel Hill
name: Abbie Smith-Ryan, PhD
role: PRINCIPAL_INVESTIGATOR
References: