Clinical trial NCT05182463: Peginterferon Treatment Study for Inactive Chronic Hepatitis B Patients
Official title: Real World Study of Peginterferon Alpha-2b Treatment for Inactive Chronic Hepatitis B Patients: E-Cure Study
Study type: INTERVENTIONAL
Overall status: RECRUITING
Phase: PHASE4
Conditions: Hepatitis B, Chronic
Keywords: inactive chronic hepatitis B
functional cure
Lead sponsor: Third Affiliated Hospital, Sun Yat-Sen University
Sponsor class: OTHER
First posted: 2022-01-10
Enrollment: 5000
Sex: ALL
Minimum age (years): 18
Maximum age (years): 60
Standard ages: ADULT
Accepts healthy volunteers: no
Allocation: NON_RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: There are about 400 million chronic hepatitis B virus (HBV) infection patients worldwide, posing a serious threat to global public health security. In China, HBV infection occured mainly in the perinatal period or infants, and about 10% of patients in the immune tolerance stage spontaneously transit to the immune clearance stage every year and become HBeAg-negative chronic HBV infection, resulting in a significant increase in the number of inactive chronic hepatitis B (CHB) patients.

In recent years, different guidelines have not reached consensus on the need to initiate antiviral therapy for inactive CHB patients: In the guidelines of Asian Pacific Association for The Study of Liver(APASL)-2015 and American Association for the Study of Liver Diseases(AASLD)-2018, antiviral therapy is generally not recommended for this group of patients, and regular outpatient follow-up is recommended. Guideline of European Association for the Study of the Liver(EASL)-2017 suggests that people with a family history of cirrhosis and liver cancer at this stage could be treated with antiviral therapy even if they did not meet the indications of antiviral therapy. According to Guidelines for the Prevention and Treatment of Chronic Hepatitis B (version 2019) of China, antiviral therapy is still recommended for some patients with inactive HBsAg carrier status who are HBV DNA positive and meet the treatment indications. Studies have shown that some patients in immune tolerance stage may enter the immune clearance stage and have hepatitis flare. Patients of inactive CHB have the potential to develop HBeAg-negative CHB, and studies of long-term follow-up in this population have indicated the risk of hepatocellular carcinoma. With the popularization of the concept of functional cure for chronic hepatitis B, more and more people with inactive CHB have a strong desire for treatment. In recent years, several studies have demonstrated that Pegylated-interferon therapy can achieve high functional cure rate in patients with inactive CHB.

The purpose of this study is to establish a national multi-center, prospective real world study to compare the efficacy of different antiviral treatment regimens for patients with inactive CHB and seek for the factors of functional cure.


Eligibility criteria: Inclusion Criteria:

* Age 18-60, no gender limitation
* HBsAg is positive for more than 6 months
* Hepatitis B e antigen(HBeAg) is negative and anti-HBe is positive
* Serum HBV DNA is less than 2000 IU/mL
* Alanine aminotransferase(ALT) and/or Aspartate aminotransferase(AST) is normal
* No antiviral durg (including nucleos(t)ide analogue and interferon) was used before enrollment
* Good compliance and voluntarily signed informed consent

Exclusion Criteria:

* Allergic to pegylated interferon α-2b
* Any indication of liver cirrhosis
* Coinfection with hepatitis A virus(HAV), hepatitis C virus(HCV), hepatitis D virus(HDV), hepatitis E virus(HEV) or human immunodeficiency virus(HIV)
* Combined with other liver diseases (including drug-related, alcoholic, autoimmune, genetic metabolic liver diseases, etc.)
* There are serious lesions in the important organs, such as heart, lung, kidney, brain and fundus
* Patients with autoimmune diseases, unstable diabetes or thyroid diseases(hyperthyroidism or hypothyroidism)
* Confirmed or suspected liver cancer or other malignant tumors
* Patients after or preparing for organ transplantation
* Peripheral blood white blood cell count \< 3.5×109/L and/or platelet count \< 80×109/L
* Under immunosuppressant treatment
* Pregnant or planned pregnancy in a short term or lactation patients
* Alcohol abuse (average alcohol intake is more than 40 g/d in males or 20g/d in women) or drug addicts
* Present or past history of mental or psychological diseases
* Other conditions that the investigators deem inappropriate for the study.

Primary outcomes:
measure: HBsAg clearance rate
timeFrame: From date of the beginning of treatment until the date of the end of treatment, assessed up to 96 weeks
Secondary outcomes:
measure: HBsAg serological conversion rate
timeFrame: From date of the beginning of treatment until the date of the end of treatment, assessed up to 96 weeks
measure: The magnitude of HBsAg decline from baseline
timeFrame: through treatment completion, an anticipated period of 96 weeks
measure: The magnitude of HBV-DNA decline from baseline and the undetectable rate
timeFrame: through treatment completion, an anticipated period of 96 weeks
measure: HBsAg clearance rate, HBsAg serological conversion rate and maintenance response rate of HBsAg clearance
timeFrame: through follow-up completion, an anticipated period of 144 weeks
Other outcomes:
Locations:
city: Guangzhou
country: China
facility: Department of Infectious Diseases, The Third Affliated Hospital of Sun Yat-sen University
state: Guangdong
Study officials:
affiliation: Third Affiliated Hospital, Sun Yat-Sen University
name: Zhiliang Gao, Doctor
role: STUDY_CHAIR
affiliation: The Second Hospital of Anhui Medical University
name: Guizhou Zou
role: PRINCIPAL_INVESTIGATOR
affiliation: The First Affiliated Hospital of Anhui Medical University
name: Jiabin Li
role: PRINCIPAL_INVESTIGATOR
affiliation: Anxi County Hospital
name: Zhende Lin
role: PRINCIPAL_INVESTIGATOR
affiliation: SHENZHEN HOSPITAL of PEKING UNIVERSITY
name: Guoxin Hu
role: PRINCIPAL_INVESTIGATOR
affiliation: Dongguan Binhai Bay Central Hospital
name: Youping Lin
role: PRINCIPAL_INVESTIGATOR
affiliation: Dongguan Ninth People's Hospital
name: Sichun Yin
role: PRINCIPAL_INVESTIGATOR
affiliation: Dongguan People's Hospital
name: Songmei He
role: PRINCIPAL_INVESTIGATOR
affiliation: Dongyuan People's Hospital
name: Zengjia Xu
role: PRINCIPAL_INVESTIGATOR
affiliation: DuShanZi People's Hospital
name: Hui Shen
role: PRINCIPAL_INVESTIGATOR
affiliation: First People's Hospital of Foshan
name: Haifei Luo
role: PRINCIPAL_INVESTIGATOR
affiliation: Gansu Wuwei Tumor Hospital
name: Wenhua Zhang
role: PRINCIPAL_INVESTIGATOR
affiliation: Guangdong Second Provincial People's Hospital
name: Maosheng Wu
role: PRINCIPAL_INVESTIGATOR
affiliation: Guangzhou Second traditional Chinese Medicine hospital
name: Dong Wei
role: PRINCIPAL_INVESTIGATOR
affiliation: Guangdong Provincial People's Hospital
name: Wenli Chen
role: PRINCIPAL_INVESTIGATOR
affiliation: Beihai People's hospital
name: Bihua Gao
role: PRINCIPAL_INVESTIGATOR
affiliation: Nanxishan Hospital of Giang xi zhuang Autonomous Region
name: Guifang Tang
role: PRINCIPAL_INVESTIGATOR
affiliation: THE PEOPLE'S HOSPITAL OF GUANGXI ZHUANG AUTCNOMOUS REGION
name: Huaiyu Song
role: PRINCIPAL_INVESTIGATOR
affiliation: The First Municipal Hospital of Guangzhou
name: Zhuxiang Zhao
role: PRINCIPAL_INVESTIGATOR
affiliation: Guangzhou Panyu Central Hospital
name: Xihua Fu
role: PRINCIPAL_INVESTIGATOR
affiliation: Second Affiliated Hospital of Guangzhou Medical University
name: Runqi Luo
role: PRINCIPAL_INVESTIGATOR
affiliation: Fifth Affiliated Hospital of Guangzhou Medical University
name: Shi Ouyang
role: PRINCIPAL_INVESTIGATOR
affiliation: GUANGZHOU EIGHTH PEOPLE'S HOSPITAL GUANGZHOU MEDICAL UNIVERSITY
name: Chunlan Zhang
role: PRINCIPAL_INVESTIGATOR
affiliation: Guigang city People's Hospital
name: Riying Lv
role: PRINCIPAL_INVESTIGATOR
affiliation: GuiYang Public Health Clinlcal Center
name: Bigang Xiong
role: PRINCIPAL_INVESTIGATOR
affiliation: the People's Hospital of Guizhou
name: Hong Peng
role: PRINCIPAL_INVESTIGATOR
affiliation: The First Affiliated Hospital of Guizhou University of traditional Chinese Medicine
name: Sufen Zhou
role: PRINCIPAL_INVESTIGATOR
affiliation: The Affiliated Hospital Of Guizhou Medical University
name: Quan Zhang
role: PRINCIPAL_INVESTIGATOR
affiliation: The Third People's Hospital of Guilin
name: YongChao Xian
role: PRINCIPAL_INVESTIGATOR
affiliation: The Third Affiliated Hospital of Sun Yat-Sen Unlversity Yuedong hospital
name: Ganwen Li
role: PRINCIPAL_INVESTIGATOR
affiliation: The Fifth Affiliated Hospital, Sun Yat-sen University
name: Jinyu Xia
role: PRINCIPAL_INVESTIGATOR
affiliation: The First Afiliated Hospital Sun Yat-sen University
name: Bihui Zhong
role: PRINCIPAL_INVESTIGATOR
affiliation: Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
name: Minhui Xiao
role: PRINCIPAL_INVESTIGATOR
affiliation: Zhongshan Sencond People's Hospital
name: Wenjun Gao
role: PRINCIPAL_INVESTIGATOR
affiliation: The fourth people's Hospital of Zibo
name: Gang Li
role: PRINCIPAL_INVESTIGATOR
affiliation: Zunyi Medical College
name: Yangwen Luo
role: PRINCIPAL_INVESTIGATOR
affiliation: The Second People's Hospital OF YULIN
name: Jie Chen
role: PRINCIPAL_INVESTIGATOR
affiliation: Red Cross Hospital of Yulin City
name: Xiaochao Qin
role: PRINCIPAL_INVESTIGATOR
affiliation: teaditional chinese medicine hospital of YULIN
name: Wuhai Qin
role: PRINCIPAL_INVESTIGATOR
affiliation: Yuebei Second People's Hospital
name: Hongshun Fan
role: PRINCIPAL_INVESTIGATOR
affiliation: Guilin Municipal Hospital of Traditonal
name: Ming Jiang
role: PRINCIPAL_INVESTIGATOR
affiliation: HANNAN GENERAL HOSPITAL
name: Feng Lin
role: PRINCIPAL_INVESTIGATOR
affiliation: Hainan Western Central Hospital
name: Chengfang Zheng
role: PRINCIPAL_INVESTIGATOR
affiliation: Heyuan people's Hospital
name: Zhentao Gu
role: PRINCIPAL_INVESTIGATOR
affiliation: THE PEOPLE'S HOSPITAL of HEZHOU
name: Fan Li
role: PRINCIPAL_INVESTIGATOR
affiliation: Huazhong University of Science and Technology Union Shenzhen Hospital
name: Qin Yan
role: PRINCIPAL_INVESTIGATOR
affiliation: Huizhou Municipal Central Hospital
name: Zhanzhou Lin
role: PRINCIPAL_INVESTIGATOR
affiliation: Hepatobiliary Hospital Of JiLin
name: Hui Chen
role: PRINCIPAL_INVESTIGATOR
affiliation: First Affiliated Hospital of Jinan University
name: Xujing Liang
role: PRINCIPAL_INVESTIGATOR
affiliation: The Affiliated Shunde Hospital of Jinan University
name: Bin Liu
role: PRINCIPAL_INVESTIGATOR
affiliation: Jiangmen Central Hospital
name: Changzheng Hu
role: PRINCIPAL_INVESTIGATOR
affiliation: The 924th Hospital of the PLA joint Logistic support Force
name: Xingchuan Wang
role: PRINCIPAL_INVESTIGATOR
affiliation: Jinjiang City Hospital
name: Chengzu Lin
role: PRINCIPAL_INVESTIGATOR
affiliation: the First People's Hopistal of Kashi
name: Guihua Su
role: PRINCIPAL_INVESTIGATOR
affiliation: Karamay Central Hospital of Xinjiang
name: Yi Wang
role: PRINCIPAL_INVESTIGATOR
affiliation: The 962th Hospital of the PLA joint Logistic support Force
name: Yuqin Xu
role: PRINCIPAL_INVESTIGATOR
affiliation: Lanzhou University Second Hospital
name: Lingyi Zhang
role: PRINCIPAL_INVESTIGATOR
affiliation: LanZhou University
name: Xiaorong Mao
role: PRINCIPAL_INVESTIGATOR
affiliation: Lanzhou University Second Hospital
name: Hong Wan
role: PRINCIPAL_INVESTIGATOR
affiliation: LIU ZHOU WORKER'S HOSPITAL
name: Qian Guo
role: PRINCIPAL_INVESTIGATOR
affiliation: LIU ZHOU PEOPLE'S HOSPITAL
name: Liu He
role: PRINCIPAL_INVESTIGATOR
affiliation: LIU ZHOU TRADITIONAL CHINESE MEDICAL HOSPITAL
name: Zhengxiao Zhao
role: PRINCIPAL_INVESTIGATOR
affiliation: Long yan hospital of traditional Chinese medicine
name: Yan Lincan
role: PRINCIPAL_INVESTIGATOR
affiliation: army 73rd group military hospital
name: Feng Min
role: PRINCIPAL_INVESTIGATOR
affiliation: Mudanjiang Kangan Hospital
name: Xiqiu Zeng
role: PRINCIPAL_INVESTIGATOR
affiliation: Second Affiliated Hospital of Nanchang University
name: Shuilin Sun
role: PRINCIPAL_INVESTIGATOR
affiliation: The First Affiliated Hospital of Nanchang University
name: Xiaoping Wu
role: PRINCIPAL_INVESTIGATOR
affiliation: The Ninth Hospital of Nanchang
name: Keqin Zhang
role: PRINCIPAL_INVESTIGATOR
affiliation: Southern Medical University, China
name: Hong Li
role: PRINCIPAL_INVESTIGATOR
affiliation: Putian Hanjiang Hospital
name: Jianzhen Yao
role: PRINCIPAL_INVESTIGATOR
affiliation: The First Hospital of Putian City
name: Liqin Cai
role: PRINCIPAL_INVESTIGATOR
affiliation: The Affiliated Hospital of Putian University
name: Rongxian Qiu
role: PRINCIPAL_INVESTIGATOR
affiliation: The People's Hospital Of QianNan
name: Sandu Liu
role: PRINCIPAL_INVESTIGATOR
affiliation: The Fourth People's Hospital of Qinghai Province
name: Qinghua Lu
role: PRINCIPAL_INVESTIGATOR
affiliation: The Sixth Affiliated Hospital of Guangzhou Medical University
name: Ying Deng
role: PRINCIPAL_INVESTIGATOR
affiliation: Quanzhou Decheng hospital
name: Xingnan Pan
role: PRINCIPAL_INVESTIGATOR
affiliation: Quanzhou First Hospital
name: Ruyi Guo
role: PRINCIPAL_INVESTIGATOR
affiliation: Quanzhou Hospital of traditional Chinese Medicine
name: Wenke Li
role: PRINCIPAL_INVESTIGATOR
affiliation: SanMing First Hospital
name: Huiwen Song
role: PRINCIPAL_INVESTIGATOR
affiliation: The First Affiliated Hospital of Xiamen University
name: Xiulan Xue
role: PRINCIPAL_INVESTIGATOR
affiliation: Xiamen Hospital of Traditional Chinese Medicine
name: Qianguo Mao
role: PRINCIPAL_INVESTIGATOR
affiliation: Xiamen Chang gung hospital
name: Haidong Zhao
role: PRINCIPAL_INVESTIGATOR
affiliation: Shan dong public Health Clinical Center
name: Yanhui Zu
role: PRINCIPAL_INVESTIGATOR
affiliation: Shantou Central Hospital
name: Ruilie Chen
role: PRINCIPAL_INVESTIGATOR
affiliation: Shenzhen Bao'an People's Hospital
name: Shu Yang
role: PRINCIPAL_INVESTIGATOR
affiliation: Shenzhen Third People's Hospital
name: Jun Chen
role: PRINCIPAL_INVESTIGATOR
affiliation: Shenzhen Luohu Hospitai of Traditional Chinese Medicine
name: Yanyao Yin
role: PRINCIPAL_INVESTIGATOR
affiliation: Shenzhen Hospital of Integrated Traditional Chinese and Western Medicine
name: Rongshan Fan
role: PRINCIPAL_INVESTIGATOR
affiliation: SHEN ZHEN TRADITIONAL CHINESE MEDICINE HOSPITAL
name: Guangdong Tong
role: PRINCIPAL_INVESTIGATOR
affiliation: The First Affiliated Hospital of Shihezi University School of Medicine
name: Weize Zuo
role: PRINCIPAL_INVESTIGATOR
affiliation: Weihai Chest Hospital
name: Bin Zhou
role: PRINCIPAL_INVESTIGATOR
affiliation: Shijiazhuang Hospital of Traditional Chinese Medicine
name: Huanwei Zheng
role: PRINCIPAL_INVESTIGATOR
affiliation: Shishi General Hospital
name: Chuantiao Zhang
role: PRINCIPAL_INVESTIGATOR
affiliation: Tianjin Third Central Hospital
name: Qing Ye
role: PRINCIPAL_INVESTIGATOR
affiliation: Tianjin First Hospital
name: Xin Chen
role: PRINCIPAL_INVESTIGATOR
affiliation: Tianshui First people's hospital
name: Changxia Niu
role: PRINCIPAL_INVESTIGATOR
affiliation: Tianshui traditional Chinese medicine hospital
name: Jiancheng Zhang
role: PRINCIPAL_INVESTIGATOR
affiliation: Weifang People's Hospital
name: Ruihai Zhu
role: PRINCIPAL_INVESTIGATOR
affiliation: The Third People's Hospital of Wuzhou
name: Zhushi Liang
role: PRINCIPAL_INVESTIGATOR
affiliation: Fujian Xianyou General Hospital
name: Qingming Zheng
role: PRINCIPAL_INVESTIGATOR
affiliation: First Affiliated Hospital of Xinjiang Medical University
name: Xiaobo Lu
role: PRINCIPAL_INVESTIGATOR
affiliation: Traditional Chinese Medicine Hospital of Xinjiang
name: Xiaozhong Wang
role: PRINCIPAL_INVESTIGATOR
affiliation: XING AN COUNTY PEOPLE'S HOSPITSL
name: Huanwen Chen
role: PRINCIPAL_INVESTIGATOR
affiliation: YANTAI QISHAN HOSPITAL
name: Haifeng Yu
role: PRINCIPAL_INVESTIGATOR
affiliation: Yili Prefecture Infectious Disease Hospital
name: Shengtao Zeng
role: PRINCIPAL_INVESTIGATOR
affiliation: Anhui Provincial Hospital
name: Lei Li
role: PRINCIPAL_INVESTIGATOR
affiliation: The First Affiliated Hospital of Anhui University of Chinese Medicine
name: Weibing Shi
role: PRINCIPAL_INVESTIGATOR
affiliation: The First Affiliated Hospital of Bengbu Medical University
name: Chuanmiao Liu
role: PRINCIPAL_INVESTIGATOR
affiliation: Cangzhou Third Hospital
name: Mei Cai
role: PRINCIPAL_INVESTIGATOR
affiliation: The 2nd Hospital of da qing City
name: Lijuan Guan
role: PRINCIPAL_INVESTIGATOR
affiliation: The 4th People's Hospital of da tong city
name: Riwang Hu
role: PRINCIPAL_INVESTIGATOR
affiliation: Yongchun County Hospital
name: Jianli Huang
role: PRINCIPAL_INVESTIGATOR
affiliation: First Affiliated Hospital of Fujian Medical University
name: Yueyong Zhu
role: PRINCIPAL_INVESTIGATOR
affiliation: Mengchao Hepatobiliary Hospital of Hujian Medical University
name: Minghua Lin
role: PRINCIPAL_INVESTIGATOR
affiliation: No.2 People's Hospital of Fuyang City
name: Ming Li
role: PRINCIPAL_INVESTIGATOR
affiliation: Guidong People's Hospital of Guangxi Zhuang Autonomous Region
name: Xianqiu Huang
role: PRINCIPAL_INVESTIGATOR
affiliation: The Second Affiliated Hospital of Harbin Medical University
name: Liying Zhu
role: PRINCIPAL_INVESTIGATOR
affiliation: The Fourth Affiliated Hospital of Harbin Medical University
name: Lei Yu
role: PRINCIPAL_INVESTIGATOR
affiliation: First Affiliated Hospital of Harbin Medical University
name: Baoshan Yang
role: PRINCIPAL_INVESTIGATOR
affiliation: The First Hospital of Hebei Medical University
name: Yuguo Zhang
role: PRINCIPAL_INVESTIGATOR
affiliation: Heilongjiang provincial hospital
name: Xiaoli Hu
role: PRINCIPAL_INVESTIGATOR
affiliation: Jilin Central General Hospital
name: Weizhong Yan
role: PRINCIPAL_INVESTIGATOR
affiliation: Affiliated Hospital of Jiaxing University
name: Xinsheng Xie
role: PRINCIPAL_INVESTIGATOR
affiliation: FUJIAN JIANOU HOSPITAL
name: Caihua Jiang
role: PRINCIPAL_INVESTIGATOR
affiliation: Jieshou City People's Hospital
name: Guoqi Hu
role: PRINCIPAL_INVESTIGATOR
affiliation: THE THIRD HOSPITAL OF JIN CHENG
name: Junmei Han
role: PRINCIPAL_INVESTIGATOR
affiliation: JIN CHENG PEOPLE'S HOSPITAL
name: Deshun Yu
role: PRINCIPAL_INVESTIGATOR
affiliation: Tang-Du Hospital
name: Jianqi Lian
role: PRINCIPAL_INVESTIGATOR
affiliation: Xijing Hospital
name: Jiuping Wang
role: PRINCIPAL_INVESTIGATOR
affiliation: The 910th Hospital
name: Zhengjun Xu
role: PRINCIPAL_INVESTIGATOR
affiliation: LIN FEN THIRD PEOPLE'S HOSPITAL
name: Fenxiang Li
role: PRINCIPAL_INVESTIGATOR
affiliation: THE SECOND HOSPITAL OF LONGYAN
name: Tonghe Wu
role: PRINCIPAL_INVESTIGATOR
affiliation: JIANYANG FIRST HOSPITAL OF NANPING
name: Fen Wu
role: PRINCIPAL_INVESTIGATOR
affiliation: The Affiliated Hospital of Inner Mongolia Medical University
name: Yun Wu
role: PRINCIPAL_INVESTIGATOR
affiliation: Ningde Municipal Hospital of Ningde Normal University
name: Houxiong Lin
role: PRINCIPAL_INVESTIGATOR
affiliation: Zhongshan Hospital Xiamen University
name: Yongyue Deng
role: PRINCIPAL_INVESTIGATOR
affiliation: Digestive Diseases Hospital of Shandong First Medical University
name: Xiao Wang
role: PRINCIPAL_INVESTIGATOR
affiliation: Shanxi Traditional Chinese Medical Hospital
name: Huaizhang Li
role: PRINCIPAL_INVESTIGATOR
affiliation: The First Affiliated Hospital of Shanxi Medical University
name: Liaoyun Zhang
role: PRINCIPAL_INVESTIGATOR
affiliation: Shaowu Municiple Hospital of Fujian Province
name: Binhong Fu
role: PRINCIPAL_INVESTIGATOR
affiliation: The Sixth People's Hospital of Shenyang
name: Ye Gu
role: PRINCIPAL_INVESTIGATOR
affiliation: The Third People's Hospital of Taiyuan
name: Ying Guo
role: PRINCIPAL_INVESTIGATOR
affiliation: Tianjin Second People's Hospital
name: Ping Li
role: PRINCIPAL_INVESTIGATOR
affiliation: TONG LIAO INFECTIOUS DISEASES HOSPITAL
name: Zhifeng Li
role: PRINCIPAL_INVESTIGATOR
affiliation: SINOPHARM TONGMEI GENERAL HOSPITAL
name: Jingning Zhao
role: PRINCIPAL_INVESTIGATOR
affiliation: The Second Affiliated Hospital of Ｘi'an Jiaotong University
name: Shuangsuo Dang
role: PRINCIPAL_INVESTIGATOR
affiliation: The First Affiliated Hospital of Ｘi'an Jiaotong University
name: Shumei Lin
role: PRINCIPAL_INVESTIGATOR
affiliation: Yanbian University Hospital
name: Hongxin Pu
role: PRINCIPAL_INVESTIGATOR
affiliation: The Sixth hospital of Handan City
name: Li Zhang
role: PRINCIPAL_INVESTIGATOR
affiliation: Hanzhong 3201 Hospital
name: Yongmei Lin
role: PRINCIPAL_INVESTIGATOR
affiliation: Hebei Hospital of Traditional Chinese Medicine
name: Chunzhi Su
role: PRINCIPAL_INVESTIGATOR
affiliation: Jiamusi Infectious Disease Hospital
name: Mingxia Jiang
role: PRINCIPAL_INVESTIGATOR
affiliation: Southeast Hospital affiliated to Xiamen University
name: Chengrun Xu
role: PRINCIPAL_INVESTIGATOR
affiliation: The 7th Hospital of Qiqihar
name: Ying Dai
role: PRINCIPAL_INVESTIGATOR
affiliation: Wuping County Hospital
name: Jiansheng Huang
role: PRINCIPAL_INVESTIGATOR
affiliation: Xiapu County Hospital
name: Qingrui Peng
role: PRINCIPAL_INVESTIGATOR
affiliation: The 2nd Affiliated Hospital of YCU
name: Weixin Wang
role: PRINCIPAL_INVESTIGATOR
affiliation: SanMing Yongan General Hospital
name: Zhigang Lin
role: PRINCIPAL_INVESTIGATOR
affiliation: Yuncheng Central Hospital
name: Shihong Wu
role: PRINCIPAL_INVESTIGATOR
affiliation: Changzhi Medical College
name: Zhongfu Zhao
role: PRINCIPAL_INVESTIGATOR
affiliation: Xinhua Hospital of Zhejiang Province
name: Yi Zheng
role: PRINCIPAL_INVESTIGATOR
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