Clinical trial NCT06263634: Hand Exercises in Psoriatic Arthritis
Official title: Investigation of the Effect of Hand Exercises on Grip Strength, Functionality, Disease Activity and Quality of Life in Patients With Psoriatic Arthritis
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Psoriatic Arthritis
Hand Rheumatism
Keywords: Psoriatic Arthritis
hand exercises
grip strength
functionality
disease activity
quality of life
Lead sponsor: Akdeniz University
Sponsor class: OTHER
First posted: 2024-02-16
Enrollment: 34
Sex: ALL
Minimum age (years): 18
Maximum age (years): 65
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Intervention model description: Randomized controlled trial
Primary purpose: TREATMENT

Brief summary: This study is a randomized controlled study examining the effects of 8-week hand home exercises on grip strength, functionality, disease activity and quality of life in patients with PsA. Individuals participating in the study will be randomly divided into 2 groups. Individuals in the intervention group will perform home exercises consisting of stretching, mobility and strengthening, 4 days a week for 8 weeks, and the patients' compliance with the exercise will be monitored by phone call once a week. Individuals in the control group are on the waiting list and the same home exercise program will be taught to the patients at the end of the study.

Detailed description: Psoriatic arthritis (PsA) is a chronic inflammatory musculoskeletal disease that is in the spondyloarthritis group and is frequently accompanied by peripheral arthritis, dactylitis, enthesitis, spondylitis and accompanied by psoriasis. Although hand effects in patients with PsA are known, there is no exercise study performed only on the hand and no study examining the effect of this study on the grip strength and functionality of the hand. This study is a randomized controlled study examining the effects of 8-week hand home exercises on grip strength, functionality, disease activity and quality of life in patients with PsA. 34 individuals with PsA who meet the inclusion criteria will be included in the study. Individuals participating in the study will be randomly divided into 2 groups. Individuals in the intervention group will perform 30-45 minutes of home exercises consisting of stretching, mobility and strengthening, 4 days a week for 8 weeks, and the patients' compliance with the exercise will be monitored by phone call once a week. Individuals in the control group are on the waiting list and the same home exercise program will be taught to the patients at the end of the study. Evaluations will be made twice, at the beginning and at the end of the 8-week program. In the evaluation, the demographic form, Psoriatic Arthritis Disease Activity Score (DAPSA), Grip Strength, Nine-Hole Peg Test, Duruöz Hand Index, Michigan Hand Outcome Questionnaire (MHQ) Functional Hand Index, Psoriatic Arthritis Quality of Life Questionnaire (PsAQoL) will be applied. This study will be one of the first studies to show the effects of hand exercises on PsA disease activity, grip strength, functionality and quality of life.

Eligibility criteria: Inclusion Criteria:

* Being diagnosed with PsA by a physician according to CASPAR criteria
* Being 18 years or older
* Involvement in hand joints (pain, swelling, tenderness)
* Being on stable drug treatment for the last 6 months
* Having sufficient cooperation to participate in the study
* Volunteering to participate in the study

Exclusion Criteria:

* Having difficulty cooperating at work
* Having additional orthopedic and/or neurological disease that will affect hand functions

Primary outcomes:
measure: Psoriatic Arthritis Disease Activity Score (DAPSA)
timeFrame: 8 weeks
measure: Hand grip strength measurement
timeFrame: 8 weeks
measure: Hand fine grip strength measurement:
timeFrame: 8 weeks
Secondary outcomes:
measure: Nine-Hole Peg Test
timeFrame: 8 weeks
measure: Duruöz Hand Index
timeFrame: 8 weeks
measure: Michigan Hand Outcome Questionnaire (MHQ)
timeFrame: 8 weeks
measure: Hand Functional Index (HFI)
timeFrame: 8 weeks
measure: Psoriatic Arthritis Quality of Life Questionnaire (PsAQoL)
timeFrame: 8 weeks
Other outcomes:
Locations:
city: Antalya
country: Turkey
facility: Akdeniz University
Study officials:
affiliation: Akdeniz University
name: Sebahat Yaprak Cetin, PhD
role: PRINCIPAL_INVESTIGATOR
References:
citation: Candiri B, Talu B, Demirtas Karaoba D, Ozaltin GE, Yolbas S. Effect of psoriatic arthritis on the strength, proprioception, skill, coordination, and functional condition of the hand. Int J Rheum Dis. 2022 Jan;25(1):47-55. doi: 10.1111/1756-185X.14241. Epub 2021 Nov 24.