Clinical trial NCT06922916: Perioperative Risk Factors Related to the Prognosis of Lung Transplantation: A Retrospective Study
Official title: Perioperative Risk Factors Related to the Prognosis of Lung Transplantation: A Retrospective Study
Study type: OBSERVATIONAL
Overall status: NOT_YET_RECRUITING
Conditions: COPD
Interstitial Pneumonia
Bronchiectasis
Respiratory Failure
Idiopathic Pulmonary Fibrosis (IPF)
Silicosis
Pulmonary Tuberculosis
Pulmonary Hypertension
Pulmonary Heart Disease
Keywords: lung transplantatipn
Perioperative-related risks
Mortality
In-hospital complications
Prognosis
Lead sponsor: Zhejiang University
Sponsor class: OTHER
First posted: 2025-04-11
Enrollment: 250
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: RETROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Patients who underwent lung transplantation at the First Affiliated Hospital of Zhejiang University between January 2017 and October 2024

Brief summary: This study analyzes patients who underwent lung transplantation at the First Affiliated Hospital of Zhejiang University from 2017 to 2024, focusing on anesthesia's impact on post-op results. It gathers patient data from hospital and Mediston systems, with main focus on in-hospital complications and secondary focus on ICU stay, post-op hospitalization, mortality, and intubation time. The research aims to deepen understanding of anesthetic management's role in lung transplant outcomes and guide improvements in perioperative anesthesia protocols.


Eligibility criteria: Inclusion Criteria:

* Age \>18 years at time of transplantation
* Received single or bilateral lung transplantation

Exclusion Criteria:

* Re-transplantation
* Multi-organ transplantation
* Autotransplantation
* Incomplete medical records: Recipients with \>20% missing essential data elements in any of these categories:Preoperative baseline characteristics； Intraoperative parameters；Postoperative outcome measures

Primary outcomes:
measure: In-hospital adverse events
timeFrame: Collect data for an expected average about 2 hours
Secondary outcomes:
measure: ICU stay
timeFrame: Collect data for an expected average about 2 hours
measure: Postoperative hospital stay
timeFrame: Collect data for an expected average about 2 hours
measure: In-hospital mortality
timeFrame: Collect data for an expected average about 2 hours
measure: 30-day postoperative mortality
timeFrame: Collect data for an expected average about 2 hours
measure: 90-day postoperative mortality
timeFrame: Collect data for an expected average about 2 hours
measure: The duration of endotracheal intubation
timeFrame: Collect data for an expected average about 2 hours
Other outcomes:
measure: Grade 3 Primary Graft Dysfunction (PGD)
timeFrame: Collect data for an expected average about 2 hours
measure: Pulmonary Infection
timeFrame: Collect data for an expected average about 2 hours
measure: Acute Kidney Injury
timeFrame: Collect data for an expected average about 2 hours
measure: Cardiovascular Events
timeFrame: Collect data for an expected average about 2 hours
measure: Hepatic Dysfunction
timeFrame: Collect data for an expected average about 2 hours
measure: Cerebral Infarction
timeFrame: Collect data for an expected average about 2 hours
Locations:
city: HangZhou
country: China
facility: The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310000
state: Zhejiang
Study officials:
References: