Clinical trial NCT06874075: Psychiatric Disorders in Child and Adolescent Offspring of Parents with Schizophrenia and Bipolar Disorders.
Official title: Psychiatric Disorders in Child and Adolescent Offspring of Parents with Schizophrenia and Bipolar Disorders.
Study type: OBSERVATIONAL
Overall status: NOT_YET_RECRUITING
Conditions: Mood Disorders
Schizophrenia Disorders
Keywords: bipolar
schizophrenia
Lead sponsor: Assiut University
Sponsor class: OTHER
First posted: 2025-03-13
Enrollment: 50
Sex: ALL
Minimum age (years): 6
Maximum age (years): 18
Standard ages: CHILD
ADULT
Accepts healthy volunteers: no
Observational model: FAMILY_BASED
Time perspective: CROSS_SECTIONAL
Sampling method: PROBABILITY_SAMPLE
Study population: families with one or two parents with psychiatric disorder.

Brief summary: Offspring of parents with bipolar disorder (BD) and schizophrenia (SZ) are vulnerable and at high risk for these disorders. Despite the fact that positive family history of SZ or BD is the strongest predictor for the development of these severe mental illnesses, there is limited evidence assessing young adults of SZ and BP simultaneously with lack of detailed handling of similarities in risk and developmental trajectories during adolescence

Detailed description: Offspring of parents with bipolar disorder (BD) and schizophrenia (SZ) are vulnerable and at high risk for these disorders. Despite the fact that positive family history of SZ or BD is the strongest predictor for the development of these severe mental illnesses, there is limited evidence assessing young adults of SZ and BP simultaneously with lack of detailed handling of similarities in risk and developmental trajectories during adolescence \[1, 2\]. SZ and BP are thought to share a common pathophysiological basis due to advances in the field of molecular genetics, which have yielded overlapping findings between the two disorders \[3, 4\]. The psychopathological base during adolescence is influenced by neurodevelopmental deviation prior to clinical onset of many severe mental illnesses \[5, 6\]. Moreover, the risk for developing psychopathology is high during adolescence and prodromal symptoms start even earlier and may overlap and are difficult to differentiate \[5-8\]. This has turned efforts towards identification and treatment of individuals at early stages of the illness, when first clinical manifestations emerge \[8, 9\].

Importantly, subthreshold symptoms of mania and depression along with unspecific behavioural, emotional, and cognitive manifestations are highly predictive of future manic and depressive episodes in BD as well as anxiety disorders, which is confirmed by the clinical staging perspective \[10, 11\]. Nevertheless, early recognition and intervention during the prodromal phase is still at an early stage in Sz \[12\] with limited research into valid prodromal criteria for BP \[13\]. Retrospective studies combining subjects with early-onset mania and early-onset first-episode psychosis have reported a similar pattern of neurodevelopmental and psychopathological features predating the appearance of more specific prodromal symptoms in both disorders \[14, 15\]. Therefore, the substantial overlap of symptoms in the initial phases suggests that early identification programmes should be aimed at detecting both the pre-psychotic and the pre-manic phases of SZ and BP \[16\]

Eligibility criteria: Inclusion Criteria:

- 6_18 years IQ \> 70 parents of schizophrenia \& mood disorders .

Exclusion Criteria:

* age \<6 or \>18 IQ \< 70 .

Primary outcomes:
measure: Early recognition of psychiatric disorders among children and adolescents , So Early interventions to decrease the severity of the disorder can be done
timeFrame: 6 months
Secondary outcomes:
measure: overlap of symptoms in the initial phases suggests that early identification
timeFrame: 6 months
Other outcomes:
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