Clinical trial NCT02039609: Nutritional Metabolomics: the Search for Dietary Exposure Variables 2
Official title: Nutritional Metabolomics: the Search for Dietary Exposure Variables 2
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Healthy
Keywords: vegetarian
vegan
omnivore
Habitual diet
Lead sponsor: Göteborg University
Sponsor class: OTHER
First posted: 2014-01-17
Enrollment: 120
Sex: ALL
Minimum age (years): 18
Maximum age (years): 65
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: OTHER
Time perspective: CROSS_SECTIONAL
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Healthy subjects Adults

Brief summary: In the post-genomic era, a major challenge for health research is to understand the complex interactions among genetic, environmental and lifestyle factors including dietary intake. Unfortunately, such initiatives are hampered by the lack of accurate dietary intake assessment methods for large studies. The newly emerging field of metabolomics offers unique possibilities to characterize individual food intake, dietary patterns and effects of dietary intervention in large studies. The investigators propose to develop a platform to detect broad metabolomic responses to food intake in controlled trials as well as to use targeted metabolomics approaches to characterize dietary intake in longitudinal studies. Our laboratory has a long history of developing methodology for assessing nutritional status and effects of diet on metabolism. Here, the investigators team up with the Sahlgrenska Academy Core Facility and the Swedish NMR Centre at the University of Gothenburg, that offer modern metabolomics equipment and competence in bioinformatics, and use this in the context of nutrition research. To their knowledge, the investigators are among the first groups in the country to develop skills in metabolomics to assess dietary intake and effects of nutrition on metabolism, and probably the first to use two complementary platforms with both mass-spectrometry and nuclear magnetic spectroscopy. Hence, our methodological results should be useful to nutritional scientists nationally as well as internationally.


Eligibility criteria: Inclusion Criteria:

Healthy Body mass index 18.0-30.0, age 18-65 yrs

Exclusion Criteria:

Regular Medication or tobacco use Pregnancy or lactating

Primary outcomes:
measure: Metabolomic patterns that reflect habitual diet
timeFrame: Fasting blood sample in the morning at one occasion
Secondary outcomes:
measure: Discriminating vegan-, vegetarian- and omnivorous diets by hair isotopic analysis
timeFrame: Hair samples in the morning at one occasion
Other outcomes:
Locations:
city: Göteborg
country: Sweden
facility: Dept Internal Medicine and Clinical Nutrition, Univ of Gothenburg
Study officials:
affiliation: Univ of Gothenburg, Sweden
name: Anna K Winkvist, PhD
role: PRINCIPAL_INVESTIGATOR
affiliation: Univ of Gothenburg, Sweden
name: Lars H Ellegard, PhD, MD
role: STUDY_CHAIR
affiliation: Univ of Gothenburg, Sweden
name: Helen M Lindqvist
role: STUDY_DIRECTOR
References:
citation: Lindqvist HM, Radjursoga M, Torstensson T, Jansson L, Ellegard L, Winkvist A. Urine Metabolite Profiles and Nutrient Intake Based on 4-Day Weighed Food Diary in Habitual Vegans, Vegetarians, and Omnivores. J Nutr. 2021 Jan 4;151(1):30-39. doi: 10.1093/jn/nxaa019.
citation: Lindqvist HM, Radjursoga M, Malmodin D, Winkvist A, Ellegard L. Serum metabolite profiles of habitual diet: evaluation by 1H-nuclear magnetic resonance analysis. Am J Clin Nutr. 2019 Jul 1;110(1):53-62. doi: 10.1093/ajcn/nqz032.