Clinical trial NCT06869109: Serum CXCL10 and CRP Levels in Patients with Acne Vulgaris in Correlation with Disease Severity
Official title: Serum CXCL10 and CRP Levels in Patients with Acne Vulgaris in Correlation with Disease Severity
Study type: OBSERVATIONAL
Overall status: NOT_YET_RECRUITING
Conditions: Acne Vulgaris
Keywords: acne vulgaris
cxcl10
crp
Lead sponsor: Assiut University
Sponsor class: OTHER
First posted: 2025-03-11
Enrollment: 88
Sex: ALL
Minimum age (years): 12
Maximum age (years): 40
Standard ages: CHILD
ADULT
Accepts healthy volunteers: yes
Observational model: OTHER
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: the patients with acne with different severity

Brief summary: the correlations between CXCL10 levels, CRP, and acne severity scores (e.g., Global Acne Grading System) suggest that CXCL10 could serve as a biomarker of inflammation and acne severity. Understanding the relationship between CXCL10, CRP, and acne severity may offer insights into novel therapeutic strategies targeting inflammatory pathways in acne.

Detailed description: Cross-sectional Observational Study. using 4 groups a 3 of different acne severity and controle one . the serum cxcl10 and crp will measured in each patient to correlate with disease severity

Eligibility criteria: Inclusion Criteria:

1. Patients aged 12-40 years diagnosed with acne vulgaris.
2. Both genders included.
3. Patients with mild, moderate, or severe acne severity as determined by a validated scoring system (e.g., Global Acne Grading System).
4. Patients not on systemic acne treatment (e.g., isotretinoin or antibiotics) or anti-inflammatory drugs.

Exclusion Criteria:

1. Patients with autoimmune diseases, systemic illnesses, acute infection or any other chronic inflammatory conditions that may affect CRP or CXCL10 levels.
2. Pregnant or lactating individuals.

Primary outcomes:
measure: Correlation of CXCL10 and CRP levels with acne severity (GAG score).
timeFrame: within one year after the result
Secondary outcomes:
measure: Identify thresholds of CXCL10 and CRP for predicting moderate/severe acne
timeFrame: within one year after the result
measure: Explore potential differences based on sex or age groups
timeFrame: within one year of the result
Other outcomes:
Locations:
city: Assiut
country: Egypt
facility: Assiut University
Study officials:
affiliation: Assiut University
name: Doaa Samir, prof
role: STUDY_DIRECTOR
affiliation: Assiut University
name: Ahmed Shawky, prof
role: STUDY_DIRECTOR
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