Clinical trial NCT01089270: Ioflupane I123 (DaTSCAN) and Positron Emission Tomography-computed Tomography Fludeoxyglucose (PET-CT FDG) to Assess Brain Function of Parkinson Patients' First Degree Relatives
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Parkinson Disease
Keywords: Parkinson
fdg pet-ct
i123 dat scan
first degree relatives of diagnosed Parkinson patients
with no clinical evidence of movement disorders
Lead sponsor: Tel-Aviv Sourasky Medical Center
Sponsor class: OTHER_GOV
First posted: 2010-03-18
Enrollment: 80
Sex: ALL
Minimum age (years): 30
Maximum age (years): 80
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: First degree relatives of diagnosed Parkinson patients that carry either LRRK2 or GBA gene mutation.

Ages: 30-80

Brief summary: Parkinson Disease is one of the most common neurodegenerative illnesses. First degree relatives of Parkinson patient are in high risk for developing the disease. We will try to detect early changes in brain metabolism before the appearance of Parkinson symptoms.

Participants: first degree relatives of diagnosed Parkinson patients that carry a gene mutation in either LRRK2 or GBA genes.

The examination results will be given to the participants by a doctor from the neurology department.


Eligibility criteria: Inclusion Criteria:

* healthy first degree relatives of diagnosed Parkinson patients

Exclusion Criteria:

* patients unable to understand and sign an informed consent
* minors
* people with psychiatric disorders or a history of major head trauma

Primary outcomes:
Secondary outcomes:
Other outcomes:
Locations:
city: Tel Aviv
country: Israel
facility: Department of Nuclear Medicine, Tel Aviv Sourasky Medical Center
Study officials:
affiliation: Tel Aviv Sourasky Medical Center, Tel Aviv, Israel
name: Einat Even-Sapir, MD, PhD
role: PRINCIPAL_INVESTIGATOR
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citation: Artzi M, Even-Sapir E, Lerman Shacham H, Thaler A, Urterger AO, Bressman S, Marder K, Hendler T, Giladi N, Ben Bashat D, Mirelman A. DaT-SPECT assessment depicts dopamine depletion among asymptomatic G2019S LRRK2 mutation carriers. PLoS One. 2017 Apr 13;12(4):e0175424. doi: 10.1371/journal.pone.0175424. eCollection 2017.