Clinical trial NCT02966600: Strength Training and Different Subtypes of Parkinson´s Disease
Official title: Effects of Progressive Resistance Exercise in Akinetic-rigid Parkinson's Disease Patients
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Parkinson Disease
Lead sponsor: University of Oviedo
Sponsor class: OTHER
First posted: 2016-11-17
Enrollment: 28
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: SUPPORTIVE_CARE

Brief summary: The aim of this randomized controlled trial was to assess the impact of progressive resistance exercise (PRE) in PD patients with akinesia and rigidity (AR-subtype). The investigators hypothesized the intervention would have a beneficial effect on the study outcomes.

Detailed description: Twenty-eight patients with PD AR-type of both sexes, were recruited for this trial. Each participant were assigned randomly to either intervention (N=13) or control (N=15) group.

The intervention group participated in sixteen PRE training sessions for eight weeks: two sessions per week on non-consecutive days, sixty-seventy min each one. The control group followed their usual weekly physical activity routine.

All patients underwent antrophometrical and neuromuscular function assessment (CoP measurements -primary outcomes- and the Ten-Meters Walk Test -TMWT- -secondary outcomes-). In addition, they were asked to provide ratings for the Spanish validated versions of the the Freezing of Gait Questionnaire (FOG-Q, 6-item version) -secondary outcomes-, the 39-item Parkinson ́s disease Questionnaire (PDQ39) -secondary outcomes- and the MDS-UPDRS -secondary outcomes-. Additionally, ratings of perceived exertion (RPE) (Borg \>6-20 scale) - secondary outcomes-, were recorded at the end of each PRE training session. Tests were carried out at three times: pre-test (before the training program), post-test (eight weeks after pre-tests, at the end of the training period), and four weeks after the post-test (re-test).

Eligibility criteria: Inclusion Criteria:

* Diagnosed with PD AR-type and Hoehn and Yahr Scale 1-2, (H\&Y)
* Do not express any type of dementia
* Able to stand for two min without assistance;
* Able to walk ten metres without assistance.

Exclusion criteria:

* To suffer a neurological disease other than PD.
* Do not meet some of the inclusion criteria.

Primary outcomes:
measure: Static posturography through the centre of pressures measurements (CoP).
timeFrame: Eight weeks
Secondary outcomes:
measure: Gait.
timeFrame: Eight weeks
measure: Freezing of gait.
timeFrame: Eight weeks
measure: The Movement Disorders Society-Unified Parkinson ́s Disease Rating Scale. (MDS-UPDRS).
timeFrame: Eight weeks
measure: The patient- perceived quality of life.
timeFrame: Eight weeks
Other outcomes:
Locations:
city: Oviedo
country: Spain
facility: University School of Sports Medicine, University of Oviedo, Spain.
state: Asturias
Study officials:
affiliation: University School of Sports Medicine, University of Oviedo, Spain. Performance and Health Group, Department of Physical Education and Sport. Faculty of Sports Sciences and Physical Education, University of A Coruna, Spain.
name: Luis Santos, PhD
role: PRINCIPAL_INVESTIGATOR
References: