Clinical trial NCT05669196: Diaphragmatic Thickness and Functional Exercise Capacity in Lobectomy Surgeries With Thoracotomy and VATS
Official title: Evaluation of Respiratory Muscle Strength, Diaphragmatic Thickness and Functional Exercise Capacity in Lobectomy Surgeries With Thoracotomy and VATS
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Video Assisted Thoracoscopic Surgery
Thoracic Surgery
Respiratory Muscles
Keywords: Lung cancer, functional capacity
Lead sponsor: Hacettepe University
Sponsor class: OTHER
First posted: 2022-12-30
Enrollment: 42
Sex: ALL
Minimum age (years): 18
Maximum age (years): 75
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Individuals with lung cancer who met the inclusion criteria in the 18-75 age range participated in the study. According to the surgical intervention methods, the patients in our study; divided into three groups as standard thoracotomy, muscle sparing thoracotomy, and VATS.

Brief summary: The most commonly treatment for early stage non-small cell lung cancer (NSCLC) is lobectomy. Different surgical interventions during lobectomy are thought to have different effects on respiratory functions and exercise capacities. The aim of this study was to evaluate respiratory muscle strength, functional exercise capacity, and diaphragmatic thickness in groups that underwent lobectomy with standard thoracotomy, muscle sparing thoracotomy, and video-assisted thoracic surgery (VATS).

Detailed description: The most commonly treatment for early stage non-small cell lung cancer (NSCLC) is lobectomy. Different surgical interventions during lobectomy are thought to have different effects on respiratory functions and exercise capacities. The aim of this study was to evaluate respiratory muscle strength, functional exercise capacity, and diaphragmatic thickness in groups that underwent lobectomy with standard thoracotomy, muscle sparing thoracotomy, and video-assisted thoracic surgery (VATS). In this study we will evaluate respiratory muscle strength, functional exercise capacity, diaphragmatic thickness, postoperative pulmonary complications, pain, dyspnea, pulmonary function, functional status, anxiety and depression.

Eligibility criteria: Inclusion Criteria:

* Being a lung cancer patient scheduled for standard thoracotomy, muscle sparing thoracotomy, or lobectomy with VATS,
* Being clinically stable,
* Volunteering to participate in the study,
* be between the ages of 18-75,
* To be cooperative in the tests to be done.

Exclusion Criteria:

* Having an orthopedic and neurological condition that prevents walking, - Having undergone any surgery on the thoracic wall,
* Diagnosed with small cell lung cancer.

Primary outcomes:
measure: Respiratory muscle strength (inspiration) change
timeFrame: The day before the operation.
measure: Respiratory muscle strength (inspiration) change
timeFrame: 15-20 days after discharge.
measure: Respiratory muscle strength (expiration) change
timeFrame: The day before the operation.
measure: Respiratory muscle strength (expiration) change
timeFrame: 15-20 days after discharge.
Secondary outcomes:
measure: Functional exercise capacity
timeFrame: The day before the operation.
measure: Functional exercise capacity
timeFrame: 15-20 days after discharge.
measure: Diaphragmatic thickness
timeFrame: The day before the operation.
measure: Diaphragmatic thickness
timeFrame: 15-20 days after discharge.
measure: Postoperative Pulmonary Complication
timeFrame: Postoperative first-fifth days.
measure: Postoperative pain
timeFrame: The operative day after the operation.
measure: Postoperative pain
timeFrame: Postoperative first-fifth days.
measure: Postoperative pain
timeFrame: 15-20 days after discharge.
measure: Dyspnea
timeFrame: The day before the operation.
measure: Dyspnea
timeFrame: 15-20 days after discharge.
measure: Pulmonary function (FEV1)
timeFrame: The day before the operation.
measure: Pulmonary function (FEV1)
timeFrame: 15-20 days after discharge.
measure: Pulmonary function (FVC)
timeFrame: The day before the operation.
measure: Pulmonary function (FVC)
timeFrame: 15-20 days after discharge.
measure: Pulmonary function (FEF25-75)
timeFrame: The day before the operation.
measure: Pulmonary function (FEF25-75)
timeFrame: 15-20 days after discharge.
measure: Pulmonary function (PEF)
timeFrame: The day before the operation.
measure: Pulmonary function (PEF)
timeFrame: 15-20 days after discharge.
measure: Functional Status
timeFrame: The day before the operation.
measure: Anxiety and Depression
timeFrame: Postoperative first-fifth days.
Other outcomes:
Locations:
city: Ankara
country: Turkey
facility: Hacettepe University
Study officials:
affiliation: Hacettepe University
name: Funda Sirakaya, MsC
role: PRINCIPAL_INVESTIGATOR
References: