Clinical trial NCT04810832: EXPRESON-IN : Intracerebral Recordings of P3a Responses to Expressive Own-names
Official title: EXPRESON-INTRA : Intracerebral Recordings of P3a Responses to Own-names Uttered by Expressive and Neutral Voices in Pharmacoresistant Epilepsy Adult Patients
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Intractable Epilepsy
Keywords: Event-related Potentials (ERP)
Intracerebral recordings
Presurgical evaluation
Lead sponsor: Centre Hospitalier St Anne
Sponsor class: OTHER
First posted: 2021-03-23
Enrollment: 20
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SEQUENTIAL
Intervention model description: Open and prospective study.

Evoked related potentials are recorded on the scalp and with intracranial electrodes for each participant while they listen 3 paradigms successively and in a random order:

i) their own name uttered by a smiling voice ii) their own name uttered by a neutral voice iii) their own name uttered by a rough voice
Primary purpose: BASIC_SCIENCE

Brief summary: Neurophysiologic evaluation of disorders of consciousness (DOC) patients in intensive care unit include late auditory evoked potentials. It allows the physicians to record cerebral responses of patients to auditory stimuli and in particularly to their own name (as the P3a response). Numerous studies try to improve the relevance of the auditory stimuli used in this paradigm and notably using more expressive stimuli.

Here the investigators investigate the intracerebral correlates of the P3a responses recorded on the scalp with neutral and more expressive stimuli.

Detailed description: Late auditory evoked potentials (as P3 wave) are used in neurophysiology to assess the level of consciousness in DOC (disorder of consciousness) patients. The P3 wave, elicited by listening standard and deviant stimuli, corresponds to the activation of a frontoparietal network and is considered to reflect a cognitive attention task. Using the own name of the patient as deviant stimuli improve the ability to detect the P3 wave because of the particularly relevance of this stimulus for the patient.

In human cognition, to identify the expressivity valence of a voice is essential. Neural processing of expressive voices should involves more widespread brain areas than neutral voices processing.

Here the investigators investigate the intracerebral correlates of the P3a responses recorded on the scalp to own-name stimuli uttered by neutral and more expressive voices (positive : smiling voice or negative : rough voice) in adult pharmacoresistant epilepsy patients.

Eligibility criteria: Inclusion Criteria:

* Intractable focal epilepsy with undergoing pre-surgical evaluation
* intracerebral electrodes implantation in auditory cortices, temporal lobe, superior temporal gyrus, limbic areas, frontal lobe
* Given Consent to inclusion

Exclusion Criteria:

* Deafness
* Pregnancy

Primary outcomes:
measure: Latencies cartography of intracranial responses to own-name uttered by neutral voice
timeFrame: 1 year
measure: Latencies cartography of intracranial responses to own-name uttered by expressive voices
timeFrame: 1 year
Secondary outcomes:
measure: Comparison between brain responses to own-name uttered by expressive voices recorded with intracerebral electrodes versus scalp electrodes
timeFrame: 1 year
measure: Comparison between brain responses to own-name uttered by neutral voices recorded with intracerebral electrodes versus scalp electrodes
timeFrame: 1 year
Other outcomes:
Locations:
city: Paris
country: France
facility: GHU Paris - Sainte Anne
Study officials:
References: