louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT01945385: Impact of Video Intervention on Postabortal Uptake of Long Acting Reversible Contraception (LARC)
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Abortion
Keywords: Abortion
LARC
Contraception
IUD
Contraceptive implant
behavioral change
video intervention
Lead sponsor: University of Chicago
Sponsor class: OTHER
Collaborators: name: Society of Family Planning
First posted: 2013-09-18
Enrollment: 193
Sex: FEMALE
Minimum age (years): 18
Maximum age (years): 29
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: HEALTH_SERVICES_RESEARCH

Brief summary: Primary: To compare rates of immediate postabortal LARC uptake between women exposed to a brief, theory-based, video intervention prior to standard contraceptive counseling and women exposed to standard counseling alone.

Secondary: To identify predictors of immediate postabortal LARC uptake among all participants including the role of:

* Demographic and reproductive health history variables
* Baseline decisional balance, self-efficacy and stage of change for contraceptive initiation

Detailed description: This is a randomized controlled trial evaluating the effect of a brief video intervention on postabortal uptake of long acting reversible contraception.

Eligibility criteria: Inclusion Criteria:

* Ages 18 - 29 Surgical abortion being performed the day of the study English speaking

Exclusion Criteria:

* Nonviable pregnancy Sexual assault Administered sedative medication Non English speaking

Primary outcomes:
measure: Postabortal LARC uptake
timeFrame: Immediate
Secondary outcomes:
measure: Perceived self efficacy surrounding LARC decision making
timeFrame: Baseline
measure: Perceived decisional balance surrounding LARC decision making
timeFrame: Immediate
measure: Stage of behavioral change around LARC uptake
timeFrame: Immediate
Other outcomes:
Locations:
city: Chicago
country: United States
facility: Planned Parenthood Near North
state: Illinois
Study officials:
affiliation: University of Chicago
name: Melissa Gilliam, MD, MPH
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT02623985: Evaluation of Accuracy of Rapid Tests for Group A Beta Hemolytic Streptococci in Out-patients With Sore Throat
Official title: Evaluation of Accuracy of Rapid Tests for Group A Beta Hemolytic Streptococci in Out-patients With Sore Throat From Acute Pharyngitis at Siriraj Hospital
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Pharyngitis
Lead sponsor: Mahidol University
Sponsor class: OTHER
First posted: 2015-12-08
Enrollment: 360
Sex: ALL
Minimum age (years): 7
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NON_RANDOMIZED
Intervention model: PARALLEL
Primary purpose: DIAGNOSTIC

Brief summary: The purpose of this study is to evaluate accuracy of rapid tests for group A beta hemolytic streptococci in patients who presented with sore throat at out patient department in Siriraj Hospital.

Detailed description: The patients who presented with sore throat at out patient department less than 5 days and age over 6 years old would be enrolled by the primary physicians and the consent forms will be completed by researcher.

The throat swab would be performed by using Sofia, QuickVue rapid tests compare to the gold standard which is a throat swab culture to evaluate the accuracy of the rapid tests.

The sample size for validation of sensitivity and specificity of rapid tests is 358 patients.

The primary outcome is will be evaluated sensitivity and specificity of both rapid tests.

Eligibility criteria: Inclusion Criteria:

* Patients who came with sore throat less than 5 days.

Exclusion Criteria:

* No

Primary outcomes:
measure: Of participants positive for Group A Streptococcus by Sofia rapid test, the percentage who are positive for Group A Streptococcus by Sofia rapid test.
timeFrame: Day 1
measure: Of participants positive for Group A Streptococcus by Sofia rapid test, the percentage who are negative for Group A Streptococcus by Sofia rapid test.
timeFrame: Day 1
measure: Of participants positive for Group A Streptococcus by QuickVue rapid test, the percentage who are positive for Group A Streptococcus by QuickVue rapid test.
timeFrame: Day 1
measure: Of participants positive for Group A Streptococcus by QuickVue rapid test, the percentage who are negative for Group A Streptococcus by QuickVue rapid test.
timeFrame: Day 1
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
References:
citation: Plainvert C, Duquesne I, Touak G, Dmytruk N, Poyart C. In vitro evaluation and comparison of 5 rapid antigen detection tests for the diagnosis of beta-hemolytic group A streptococcal pharyngitis. Diagn Microbiol Infect Dis. 2015 Oct;83(2):105-11. doi: 10.1016/j.diagmicrobio.2015.06.012. Epub 2015 Jun 23.
Clinical trial NCT06702085: Lifestyle Changes in Older Adults With Metabolic Syndrome and Tinnitus
Official title: Effects of Lifestyle Changes on Tinnitus in Older Adults With Metabolic Syndrome
Study type: INTERVENTIONAL
Overall status: RECRUITING
Phase: NA
Conditions: Tinnitus
Metabolic Syndrome X
Obesity
Elderly
Weight Loss
Lead sponsor: Cairo University
Sponsor class: OTHER
First posted: 2024-11-22
Enrollment: 60
Sex: ALL
Minimum age (years): 65
Maximum age (years): 75
Standard ages: OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The problem of tinnitus (subjective type) is prevalent in obese older adults with different diseases such as metabolic syndrome. The changes of lifestyle are very important to lose weight, improve tinnitus and metabolic syndrome

Detailed description: Sixty older adults (with metabolic syndrome with chronic subjective tinnitus) with obesity were selected in a equal random manner to be classified into the first group that administered changes in their lifestyle (exercise applied on treadmill and low caloric diet) for twelve successive weeks and second group that was not administered lifestyle changes

Eligibility criteria: Inclusion Criteria:

* obese person (class one obesity)
* patients with metabolic syndrome
* patients with chronic subjective tinnitus (bilateral complaint from more than six months).
* older adults aging 65 years and more
* both sexes will be included

Exclusion Criteria:

* respiratory insult
* cardiac insult
* liver insult
* kidney insult
* lower limb insult
* neurological insult

Primary outcomes:
measure: visual analogue scale of tinnitus severity
timeFrame: twelve weeks
Secondary outcomes:
measure: visual analogue scale of tinnitus related discomfort
timeFrame: twelve weeks
measure: tinnitus handicap inventory
timeFrame: twelve weeks
measure: body mass index
timeFrame: twelve weeks
measure: waist circumference
timeFrame: twelve weeks
measure: triglycerides
timeFrame: twelve weeks
measure: high density lipoprotein
timeFrame: twelve weeks
measure: systolic blood pressure
timeFrame: twelve weeks
measure: diastolic blood pressure
timeFrame: twelve weeks
measure: fasting blood glucose
timeFrame: twelve weeks
Other outcomes:
Locations:
city: Dokki
country: Egypt
facility: Cairo University
state: Giza
city: Dokki
country: Egypt
facility: faculty of physical therapy Cairo university
state: Giza
Study officials:
affiliation: Cairo University
name: Ali MA Ismail, Lecturer
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT06884085: A Study to Compare to PK Characteristics and Safety Profiles Between AD-227 and Co-administration of AD-227A and AD-227B
Official title: An Open-label, Randomized, Single-dose, 2-sequence, 2-period, Crossover Study to Evaluate the Safety and Pharmacokinetics of AD-227 Compared to Co-administration of AD-227A and AD-227B in Healthy Adult Volunteers Under Fasting Conditions
Study type: INTERVENTIONAL
Overall status: RECRUITING
Phase: PHASE1
Conditions: Primary Hypertension
Lead sponsor: Addpharma Inc.
Sponsor class: INDUSTRY
First posted: 2025-03-19
Enrollment: 60
Sex: ALL
Minimum age (years): 19
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: CROSSOVER
Primary purpose: TREATMENT

Brief summary: Primary endpoint of this study is to evaluate the pharmacokinetic characteristics of AD-227 in healthy subjects.


Eligibility criteria: Inclusion Criteria:

* Body weight equal to or greater than 50kg (Female 45kg) and Body mass index (BMI) between 18.0 kg/m2 and 30.0 kg/m2 at the time of screening visit
* The Age equal to or greater than 19 in healthy volunteers at the time of screening visit

Exclusion Criteria:

* Participation in another clinical study with an investigational drug within the 6 months from scheduled first administration
* Other exclusions applied

Primary outcomes:
measure: Maximum concentration of drug in plasma (Cmax)
timeFrame: pre-dose (0hour) to 72hours
measure: Area under the plasma concentration-time curve during dosing interval (AUCt)
timeFrame: pre-dose (0hour) to 72hours
Secondary outcomes:
Other outcomes:
Locations:
city: Seoul
country: Korea, Republic of
facility: Central Hospital
Study officials:
References:
Clinical trial NCT03830385: Paclitaxel (Albumin Bound),Bleomycin And Cisplatin Or Carboplatin for Recurrent Or Metastatic Squamous Cell Carcinoma Of The Head And Neck
Official title: Open-Label, Multicenter, Phase Ⅱ Study Of Paclitaxel (Albumin Bound),Bleomycin And Cisplatin Or Carboplatin As First-Line Treatment In Patients With Recurrent Or Metastatic Squamous Cell Carcinoma Of The Head And Neck
Study type: INTERVENTIONAL
Overall status: RECRUITING
Phase: PHASE2
Conditions: Squamous Cell Carcinoma Of The Head And Neck
Lead sponsor: Sun Yat-sen University
Sponsor class: OTHER
First posted: 2019-02-05
Enrollment: 51
Sex: ALL
Minimum age (years): 18
Maximum age (years): 70
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: TREATMENT

Brief summary: The purpose of this single arm, phase Ⅱ clinical trail is to determine the safety and efficacy of paclitaxel (albumin bound),bleomycin and cisplatin or carboplatin in the treatment of recurrent Or metastatic squamous cell carcinoma of the head and neck


Eligibility criteria: Inclusion Criteria:

* biopsy proved squamous cell carcinoma of the head and neck;
* stage IVc according to Union for International Cancer Control (UICC) edition VIII, or recurrent disease after chemotherapy and/or radiotherapy;
* 18 years or older; without other malignancy;
* proper functioning of the major organs.

Exclusion Criteria:

* allergic to paclitaxel (albumin bound) or bleomycin or cisplatin or carboplatin ;
* female within gestation period or lactation;
* patients received drug of other clinical trial within 3 months

Primary outcomes:
measure: overall survival
timeFrame: 5 years
Secondary outcomes:
Other outcomes:
Locations:
city: Guangzhou
country: China
facility: Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University
state: Guangdong
Study officials:
References:
Clinical trial NCT01069185: Differences in Morbidity Between a Necessity Endotracheal Suctioning Protocol Versus a Routine Endotracheal Suctioning
Official title: Differences in Morbidity Frequency Between a Necessity Endotracheal Suctioning Protocol Versus a Routine Endotracheal Suctioning Protocol in Hospital Pablo Tobon Uribe´s Pediatric Intensive Care Unit (PICU). A Randomized Controlled Trial
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Hypoxemia
Arrhythmias
Cardiac Arrest
Ventilator Associated Pneumonia
Keywords: Unplanned extubation
Length of stay in PICU
Length of mechanical ventilation
Lead sponsor: Hospital Pablo Tobón Uribe
Sponsor class: OTHER
First posted: 2010-02-17
Enrollment: 92
Sex: ALL
Minimum age (years): 1
Maximum age (years): 14
Standard ages: CHILD
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: Morbidity frequency associated to a endotracheal suctioning is different between a necessity endotracheal suctioning protocol versus a routine endotracheal protocol.

Detailed description: Endotracheal aspiration is a very useful procedure. It has several adverse events every time that aspiration is practiced. This trials wants to identify which protocol (necessity versus routine) could be better to practice in pediatrics intensive care unit with less risk.

Eligibility criteria: Inclusion Criteria:

* Children older than 1 month until 14 years old requiring orotracheal intubation

Exclusion Criteria:

* High frequency ventilation mode

Primary outcomes:
measure: Primary Composite End Point
timeFrame: Every component for primary outcome can be assessed during or after suctioning is applied.For routine protocol, every 2 hours for necessity protocol will depend on patient´s necessity. The assessment was done in each patient during intubation period .
Secondary outcomes:
measure: Mechanical Ventilation Length as Days.
timeFrame: Every day while patient really is intubated.
Other outcomes:
Locations:
city: Medellin
country: Colombia
facility: Hospital Pablo Tobon Uribe
state: Antioquia
Study officials:
affiliation: Hospital Pablo Tobon Uribe
name: Gloria L Lema, MD
role: PRINCIPAL_INVESTIGATOR
References:
citation: Lema-Zuluaga GL, Fernandez-Laverde M, Correa-Varela AM, Zuleta-Tobon JJ. As-needed endotracheal suctioning protocol vs a routine endotracheal suctioning in Pediatric Intensive Care Unit: A randomized controlled trial. Colomb Med (Cali). 2018 Jun 30;49(2):148-153. doi: 10.25100/cm.v49i2.2273.
Clinical trial NCT00228085: Changes of Parameters of Transcranial Magnetic Stimulation in Patients With Spinal Cord Injury
Official title: Reorganization of Cortical Motor Activation in Patients With Spinal Cord Injury: a Study of Motor Evoked Potential
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Spinal Cord Injury
Lead sponsor: National Taiwan University Hospital
Sponsor class: OTHER
First posted: 2005-09-28
Enrollment: 40
Sex: ALL
Minimum age (years): 18
Maximum age (years): 70
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: DEFINED_POPULATION
Time perspective: OTHER

Brief summary: CNS reorganization is evidenced in patients with CNS lesion, no exception to the patients with spinal cord injury. The paraplegics have to increase their loading of upper extremities to compesate the lost function of lower extremities. We hypothesize that CNS reorganization can happen in the chronic paraplegics. We try to compare the changes of parameters of transcranial magnetic stimulation in these patients with the normal population cross-sectionally.


Eligibility criteria: Inclusion Criteria:

* patients with complete thoracic spinal cord injury
* onset \> 6 months
* ASIA scale: A
* normal bilateral upper extremities

Exclusion Criteria:

* Evidence of brain injury
* Evidence of peripheral neuropathy
* Active major medical diseases (eg: fever, maligancies, DM, liver or kidney diseases)

Primary outcomes:
Secondary outcomes:
Other outcomes:
Locations:
city: Taipei
country: Taiwan
facility: National Taiwan University Hospital
Study officials:
affiliation: National Taiwan University Hospital
name: Chein-Wei Chang, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT06455085: RESTORE: REducing Future fractureS and Improving ouTcOmes of fRagility fracturE
Official title: RESTORE: REducing Future fractureS and Improving ouTcOmes of fRagility fracturE
Study type: INTERVENTIONAL
Overall status: RECRUITING
Phase: NA
Conditions: Osteoporosis
Osteoporotic Fractures
Lead sponsor: University of Alabama at Birmingham
Sponsor class: OTHER
Collaborators: name: Patient-Centered Outcomes Research Institute
First posted: 2024-06-12
Enrollment: 2634
Sex: ALL
Minimum age (years): 50
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: PREVENTION

Brief summary: RESTORE tests whether Augmented-FLS, where patients are contacted by a patient navigator (serving as the liaison) and referred to a bone health provider, is better than Enhanced Usual Care, which includes patient and PCP education and activation. We also aim to determine the influence of age, race, ethnicity, sex, poverty level, geographic region, and timing of entry into the trial after a fracture on the effectiveness of the two strategies.


Eligibility criteria: Inclusion Criteria:

* Age 50 years and older (no upper age limit)
* Sustained a primary fragility fracture (hip/femur/pelvis, clinical spine, humerus, wrist/forearm) in the last 6 months
* Participant must self-identify a regular primary care provider (PCP)

Exclusion Criteria:

* Exposure to the following medications in the prior 12 months

  * Actonel or Atelvia (risedronate)
  * Fosamax or Binosto (alendronate)
  * Reclast, Zometa, or Aclasta (zoledronic acid, zoledronate)
  * Boniva or Bondronat (ibandronate)
  * Aredia (pamidronate)
  * Prolia (denosumab)
  * Evenity (romozosumab)
  * Tymlos (abaloparatide)
  * Forteo (teriparatide)
  * Natpara (parathyroid hormone)
  * Evista (raloxifene)
  * Miacalcin (calcitonin)
* Diagnosis of the following medical conditions

  * CKD stage 4 and above
  * Paget's disease
  * Multiple myeloma
  * Osteomalacia
  * Addison's disease
  * Adrenal insufficiency
  * Enrolled hospice care
  * Solid organ transplant
  * Bone marrow transplant
* Fractures resulting from severe trauma
* Scheduled appointment with a bone health clinician

Primary outcomes:
measure: Incidence of subsequent fracture
timeFrame: 24 months post randomization
Secondary outcomes:
Other outcomes:
Locations:
city: Birmingham
country: United States
facility: University of Alabama at Birmingham
state: Alabama
Study officials:
affiliation: University of Alabama at Birmingham
name: Kenneth Saag, MD, MSc
role: PRINCIPAL_INVESTIGATOR
affiliation: University of Alabama at Birmingham
name: Maria Danila, MD, MSPH
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT04620785: Photodynamic Therapy in Treatment of Verrucae
Official title: PHOTODYNAMIC THERAPY USING METHYLENE BLUE AND INTENSE PULSED LIGHT VERSUS INTENSE PULSED LIGHT ALONE IN TREATMENT OF VERRUCA :A RANDOMIZED CONTROLLED STUDY
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Verruca Vulgaris
Lead sponsor: Alexandria University
Sponsor class: OTHER
First posted: 2020-11-09
Enrollment: 80
Sex: ALL
Minimum age (years): 16
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: To assess the efficacy (clinically and dermoscopically) and safety of photodynamic therapy using intralesional injection of 4% methylene blue solution as a photosensitizer with IPL versus IPL only in treatment of warts.

Detailed description: This study will be conducted on:

Eighty patients suffering of verruca (male and female) divided randomly into three groups: group A, B\&C :

Group A: 30 patients will undergo photodynamic therapy using intralesional 4%methylene blue solution and IPL.

Group B: 30 patients will undergo IPL only. Group C (control group):20 patients will undergo intralesional saline.

Eligibility criteria: Inclusion Criteria:

1. Age:Above 16 years old.
2. Sex:Both males and female patients.
3. Clinically and dermoscopically documented verruca.
4. No verruca treatment in the last 2 weeks.

Exclusion Criteria:

1. History of photosensitivity disorder.
2. Pregnant and lactating females.
3. Diseases with risk of koebnerization e.g. Psoriasis and Lichen planus.
4. Anogenital warts.
5. Warts on head and neck.

Primary outcomes:
measure: disappearance of verruca
timeFrame: 10 weeks
Secondary outcomes:
Other outcomes:
Locations:
city: Alexandria
country: Egypt
facility: Alexandria University Faculty of Medicine
Study officials:
References:
Clinical trial NCT04921085: Nutritional Status Study of Inpatients in Hospitals
Official title: Nutritional Status Study of Inpatients in Hospitals
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Nutritional Status
Lead sponsor: Second Affiliated Hospital, School of Medicine, Zhejiang University
Sponsor class: OTHER
Collaborators: name: First Affiliated Hospital of Wenzhou Medical University
name: Zhejiang University
name: Zhejiang Provincial People's Hospital
name: The Second Affiliated and Yuying Children's Hospital of Wenzhou Medical University
name: Sir Run Run Shaw Hospital
name: Red Cross Hospital, Hangzhou, China
name: Jinhua Municipal Central Hospital
name: Quzhou People' s Hospital
name: The Central Hospital of Lishui City
name: Lishui People' s Hospital
name: Jinhua People' s Hospital
name: Yuyao People's Hospital
name: Ningbo No. 1 Hospital
name: Taizhou Hospital of Zhejiang Province affiliated to Wenzhou Medical University
name: Affiliated Wenling Hospital of Wenzhou Medical University
name: Zhejiang Hospital
name: Huizhou Municipal Central Hospital
name: The First People's Hospital of Huzhou
name: Cancer Hospital of The University of Chinese Academy of Sciences
name: Hangzhou Medical College
name: Zhejiang Provincial Tongde Hospital
name: Shaoxing People's Hospital
First posted: 2021-06-10
Enrollment: 5000
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: CROSS_SECTIONAL
Sampling method: NON_PROBABILITY_SAMPLE
Study population: adult inpatients with within 7 categories of diseases (including digestive system, respiratory system, cardiovascular and endocrine system, tumor, nervous system, and urinary system)

Brief summary: evaluating the nutritional status of inpatients with 7 catogories of diseases ( including digestive system, respiratory system, cardiovascular and endocrine system, tumor, nervous system, urinary system) within 24\~48 hours after admission. Among them, the Second Affiliated Hospital of Zhejiang University School of Medicine has undertaken 200 cases, and a total of 25 hospitals in zhejiang participated（5000 cases in total）.


Eligibility criteria: Inclusion Criteria:

* Inpatients with 7 categories of diseases (including digestive system, respiratory system, cardiovascular and endocrine system, tumor, nervous system, and urinary system)
* Age ≥ 18
* 24～48h after admission

Exclusion Criteria:

* Age\<18
* Critically ill patient
* With mental illness and cannot think or behavior normally
* Any other serious or uncontrolled illness which the investigator think is undesirable for the patient to enter the trial

Primary outcomes:
measure: Nutritional risk screening scored with NRS 2002 questionnaire
timeFrame: 24~48 hours after admission
Secondary outcomes:
measure: Body fat mass
timeFrame: 24~48 hours after admission
measure: Body muscle mass
timeFrame: 24~48 hours after admission
Other outcomes:
Locations:
city: Hangzhou
country: China
facility: 2nd Affiliated Hospital, School of Medicine, Zhejiang University
state: Zhejiang
Study officials:
References: