louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT01904175: Registry Study of T Cell Depleted Allo Non-Myeloablative Stem Cell Transplant
Official title: Registry Study of T Cell Depleted Allogeneic Non-Myeloablative Stem Cell Transplant Recipients
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Hodgkin's Disease
Non Hodgkin's Lymphoma
Myeloma
Leukemia
Myelodysplasia
Keywords: Stem cell transplantation, non-myeloablative
Lead sponsor: Duke University
Sponsor class: OTHER
First posted: 2013-07-22
Enrollment: 48
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: CASE_ONLY
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Subjects ≥ 18 years of age undergoing a reduced intensity allogeneic stem cell transplant

Brief summary: Allogeneic transplantation is used to treat many malignant and non-malignant diseases. The investigators and others have shown that less toxic preparative regimens (reduced intensity or 'mini' transplants) allow reliable allogeneic engraftment and durable remissions, significantly broadening the population of patients who may be offered this therapy to those who are older and more infirmed. The field is now focusing on the period post transplant for approaches to immune recovery leading to improved outcomes.

The primary objective of this registry is to catalogue data from patients who undergo standard of care reduced intensity allogeneic transplantation.

Detailed description: Subjects will have toxicity monitored and reported per the Center for International Blood and Marrow Transplant Research (CIBMTR) program standard and as required by law for bone marrow transplant (BMT) reporting in the USA. Data will be collected from physical exam, laboratory studies, radiographs that are performed for clinical purposes. The tests and procedures are not in addition or in excess of our standards for allogeneic transplant outside of this registry. Data about donors will also be collected.

Eligibility criteria: Recipient Inclusion Criteria:

* Subjects ≥ 18 years of age undergoing a reduced intensity allogeneic transplant

Exclusion Criteria:

* Subjects \< 18 years of age
* Subjects not undergoing nonmyeloablative or ablative allogeneic transplant

Primary outcomes:
measure: Catalogue Data
timeFrame: 1 year
Secondary outcomes:
Other outcomes:
Locations:
city: Durham
country: United States
facility: Duke University Health System
state: North Carolina
Study officials:
affiliation: Duke Health
name: David Rizzieri, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT05015075: Cardiac Rehabilitation After Pacemaker Implantation
Official title: Role of Early Short-term Cardiac Rehabilitation in Patients Undergoing Pacemaker Implantation
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE4
Conditions: Bradycardia
Pacemaker
Lead sponsor: Pusan National University Hospital
Sponsor class: OTHER
First posted: 2021-08-20
Enrollment: 27
Sex: ALL
Minimum age (years): 19
Maximum age (years): 75
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The investigators assessed whether short-term cardiac rehabilitation following pacemaker implantation was enough to improve both physical function and quality of life.

Detailed description: Exercise-based cardiac rehabilitation (CR) improves clinical outcomes in patients with cardiovascular diseases. However, few data exist regarding the role of early short-term CR in patients undergoing pacemaker (PM) implantation. The investigators assessed whether short-term CR following PM implantation was enough to improve both physical function and quality of life (QOL).

Eligibility criteria: Inclusion Criteria:

* patients who were scheduled to undergo new PM implantation

Exclusion Criteria:

* patients older than 75 years
* patients who are contraindicated to exercise
* patients who refuse to participate

Primary outcomes:
measure: changes in physical function based on cardiopulmonary exercise test
timeFrame: 1 month
Secondary outcomes:
measure: changes in physical function based on muscle power test
timeFrame: 1 month
measure: changes in quality of life
timeFrame: 1 month
Other outcomes:
Locations:
city: Busan
country: Korea, Republic of
facility: Jinhee Ahn
Study officials:
References:
Clinical trial NCT06272175: Immediate Effects of Open and Closed Kinetic Chain Exercises on Upper Extremity in Stroke Patients.
Official title: Immediate Effects of Open and Closed Kinetic Chain Activities on Upper Extremity Spasticity and Motor Dexterity in Stroke Patients"
Study type: INTERVENTIONAL
Overall status: RECRUITING
Phase: NA
Conditions: Stroke
Keywords: Stroke
Spasticity
Dexterity
Open Kinetic Chain
Closed Kinetic Chain
Lead sponsor: Istinye University
Sponsor class: OTHER
First posted: 2024-02-22
Enrollment: 50
Sex: ALL
Minimum age (years): 18
Maximum age (years): 70
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: Stroke is a sudden disruption of blood flow to the brain, resulting in physical and mental disabilities. It's a global health issue affecting millions each year, often leading to paralysis, altered muscle tone, and loss of motor control and balance. This study aims to examine the immediate effects of open and closed kinetic chain activites on upper extremity spasticity and motor dexterity in hemiplegic patients. This study will be conducted simultaneously at İstinye University Hospital Medical Park Gaziosmanpaşa and İstinye University Physiotherapy and Rehabilitation Application and Research Center (İSÜFİZYOTEM). 50 stroke patients will be included in the study, and all participants will be asked to sign an informed consent form. At the beginning of the session, all participants will be evaluated for their socio-demographic characteristics by a questionnaire created by the researchers, muscle viscoelastic properties by MyotonPRO, upper extremity muscle tone by Modified Ashworth Scale, upper extremity motor dexterity by Box and Block Test, and upper extremity joint range of motion by goniometer and by a phone application named as PhysioMaster. After the assessment, participants will be randomly assigned to two groups: open kinetic chain activity group and closed kinetic chain activity group. After performing the exercises, all evaluations will be conducted again. Thus, the aim is to understand the immediate effects of two different group exercises on the evaluated parameters.


Eligibility criteria: Inclusion Criteria:

* Stroke diagnosis;
* Hemiplegia;
* Subacute\&chronic phase (more than 3 months);
* Brunnstrom 3-4-5;
* Unsupported sitting ability;
* Being volunteer.

Exclusion Criteria:

* Having Botox within the last 6 months;
* 4 according to Modified Ashworth Scale;
* Other neurological diagnosis other than stroke.

Primary outcomes:
measure: MyotonPRO digital palpation device
timeFrame: 6 minutes
measure: Box and Block Test
timeFrame: 1 minute
Secondary outcomes:
measure: Modified Ashworth Scale
timeFrame: 3 minutes
measure: Goniometer
timeFrame: 5 minutes
measure: PhysioMaster
timeFrame: 5 minutes
Other outcomes:
Locations:
city: Istanbul
country: Turkey
facility: Istinye University Hospital Medical Park Gaziosmanpasa
Study officials:
affiliation: Istinye University
name: Merve Can
role: STUDY_CHAIR
affiliation: Istinye University
name: Seyhan Söyüncü
role: STUDY_CHAIR
References:
Clinical trial NCT06732375: Pilot Study of Mindset Moments Among Adolescent and Young Adult Cancer Survivors
Official title: Pilot Study of Mindset Moments Among Adolescent and Young Adult Cancer Survivors
Study type: INTERVENTIONAL
Overall status: RECRUITING
Phase: NA
Conditions: Cancer
Youth Cancer
Young Adult Cancer
Distress, Psychological
Keywords: young adult cancer survivor
distress
youth cancer survivor
resilience
Lead sponsor: Duke University
Sponsor class: OTHER
First posted: 2024-12-13
Enrollment: 40
Sex: ALL
Minimum age (years): 19
Maximum age (years): 25
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: SUPPORTIVE_CARE

Brief summary: The purpose of this study is to evaluate the feasibility and acceptability of the Mindset Moments™ (MM™) program in managing psychological distress and resiliency in adolescent and young adult cancer survivors.

Study participation will involve attending 8 weekly, one hour, live online group sessions and completing daily 5 minute activities such as guided imageries and CBT check in within the app. Participants will also be asked to complete an online survey at the time of enrollment and at 4 and 8 weeks.


Eligibility criteria: Inclusion Criteria:

* 19-25 years of age
* Prior AYA cancer diagnosis
* Completed primary treatment for their cancer
* Score of 3 or above on the Distress Thermometer at the time of recruitment

Exclusion Criteria:

* Individuals without legal capacity to give consent
* Individuals who are not fluent in reading, writing, and speaking English

Primary outcomes:
measure: Anxiety as measured by the Patient-Reported Outcomes Measurement Information System (PROMIS)
timeFrame: 8 weeks
Secondary outcomes:
measure: Depression as measured by the Patient-Reported Outcomes Measurement Information System (PROMIS)
timeFrame: 8 weeks
measure: Symptoms of Post-Traumatic Stress Disorder (PTSD) as measured by the PCL-5
timeFrame: 8 weeks
measure: Distress as measured by the National Comprehensive Cancer Network's (NCCN) Distress Thermometer (DT)
timeFrame: 8 weeks
measure: Ability to deal with stressful situations as measured by the Shift-and-Persist Scale
timeFrame: 8 weeks
Other outcomes:
Locations:
city: Durham
country: United States
facility: Duke Cancer Institute
state: North Carolina
Study officials:
affiliation: Duke University
name: Sophia K Smith, PhD, MSW
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT01792375: Concurrent Membrane Sweeping With Dinoprostone Versus Dinoprostone in Labor Induction of Nulliparas at Term With an Unfavorable Cervix
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Nulliparous Women Who Scheduled for Labor Induction
Keywords: Cervical ripening
Dinoprostone
Labor induction
Membrane sweeping
Nulliparous women
Trial
Lead sponsor: Seoul National University Hospital
Sponsor class: OTHER
First posted: 2013-02-15
Enrollment: 192
Sex: FEMALE
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: To compare concurrent membrane sweeping with dinoprostone versus dinoprostone in labor induction for nulliparas at term with an unfavorable cervix


Eligibility criteria: Inclusion Criteria:

* singleton pregnancy
* Nulliparous women
* gestational age \>=37.0 weeks
* Bishop score \<=6
* intact amniotic membrane
* absence of labor
* live fetus with vertex presentation
* no previous uterine surgical procedure

Exclusion Criteria:

* Multiple pregnancy
* Placenta previa

Primary outcomes:
measure: Vaginal delivery within 24 hours
timeFrame: Twenty-four hours of initiating intervention (i.e. membrane sweeping or PG) on the first day of induction
Secondary outcomes:
measure: Cervical change in the bishop scores and cervical lengths
timeFrame: Initiation of oxytocin after removing dinoprostone vaginal insert
Other outcomes:
Locations:
city: Seongnam-si
country: Korea, Republic of
facility: Department of Obstetrics and Gynecology Seoul National University Bundang Hospital
state: Gyeonggi-do
Study officials:
affiliation: Seoul National University Bundang Hospital
name: Kyo Hoon Park, MD, PhD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT03280875: Creation of an Algorithm for the Personalisation of Pedalling Exercises
Official title: Personalisation of Exercise by Muscle Modulation, Step 1: Construction and Validation of an Algorithm for Personalisation for Pedalling Exercises
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Aging
Lead sponsor: Centre Hospitalier Universitaire Dijon
Sponsor class: OTHER
First posted: 2017-09-13
Enrollment: 133
Sex: ALL
Minimum age (years): 18
Maximum age (years): 75
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: OTHER

Brief summary: The aim of the EXO-MODE project is to develop an innovative algorithm for the personalisation of Concentric and / or Eccentric training programmes adapted to the individual to improve the efficiency and tolerance. This algorithm will make it possible to personalise trainings programmes according to the different profiles of subjects, determined on the basis of their personal characteristics (age, sex, comorbidities), their exercise capacity and muscle performance, their level of motivation and their perception of the workload, and of the principal objective of the training programme. The final goal is to develop a tool to allow elderly populations to exercise more easily and more effectively.


Eligibility criteria: Inclusion Criteria:

* Subject able to understand simple instructions and to provide consent
* Men or women aged 18 to 75 years old.
* Subjects who engage in moderate physical activity (Level 1 or 2 defined by the recommendations for the classification of subjects during performance studies) \[2\].

Exclusion Criteria:

* Persons without national health insurance cover,
* Cardio-respiratory failure, coronaropathy, severe obstructive cardiomyopathy,
* Recent history of venous thromboembolism (previous 3 months),
* Any medical disorder that could have a major impact on functional capacities (examples: non-stabilised metabolic disorders, such as progressive renal failure, severe asthenia related to a non-stabilised disease, such as neoplasia, systemic disease...),
* Physical disability affecting the lower limbs or the pelvis that could impair or prevent exercise on a cycle ergometer, whether neurological (central or peripheral), arterial (i particular, arteriopathy of the lower limbs with a systolic index \< 0.6) or orthopaedic (degenerative or inflammatory rheumatism).
* Pregnant or breast-feeding women

Primary outcomes:
measure: Preliminary phase: level of perception of effort dissociated from the pain felt
timeFrame: through study phase completion, an average of 3 months
measure: Phase 1:level of pain measured by visual analog scale
timeFrame: through study phase completion, an average of 9 months
Secondary outcomes:
Other outcomes:
Locations:
city: Dijon
country: France
facility: CHU dijon Bourgogne
Study officials:
References:
Clinical trial NCT03289975: Early Identification of Patients in Surgical Intensive Care With a Risk of Acute Respiratory Distress Following Visceral Surgery
Official title: Early Identification of Patients in Surgical Intensive Care With a Risk of Acute Respiratory Distress Following Visceral Surgery: Prognostic Value of Pulmonary Extravascular Water Revealed by Pulmonary Ultrasound.
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Digestive Surgery
Urinary Surgery
Lead sponsor: Centre Hospitalier Universitaire Dijon
Sponsor class: OTHER
First posted: 2017-09-21
Enrollment: 165
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: OTHER
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Patients undergoing digestive or urinary surgery and requiring post-operative intensive care

Brief summary: Today there are few studies in the literature involving patients in an ICU following major visceral surgery. There are thus few results about the prognostic value of pulmonary extravascular water in this population of patients, but also the prognostic value of pulmonary extravascular water measured at the bedside using pulmonary ultrasound.

In addition, pulmonary ultrasound will be combined with echocardiography to measure left ventricular function (LVEF) and to study the profile of the mitral valve to assess filling pressure in patients with immediate post-operative ventilation. This will make it possible to distinguish between increases in pulmonary extravascular water associated with high filling pressure and increased pulmonary water associated with low filling pressure: characteristic of lesional oedema.

The aim of this study is to determine the prognostic value of extravascular pulmonary water (PEVW) diagnosed using pulmonary ultrasound in patients admitted to an ICU following scheduled or emergency visceral surgery in the onset of acute respiratory distress requiring invasive mechanical ventilation, or prolonged post-operative intubation, or non-invasive.


Eligibility criteria: Inclusion Criteria:

All patients undergoing scheduled or emergency visceral surgery and admitted to an ICU following the intervention.

Exclusion Criteria:

* Chest surgery
* ASA (American Society of Anesthesiologists) 4 or more
* Refusal of the patient
* Pregnant women
* Spontaneously-breathing patients

Primary outcomes:
measure: Onset of post-operative acute respiratory distress
timeFrame: 28 days
Secondary outcomes:
Other outcomes:
Locations:
city: Dijon
country: France
facility: Chu Dijon Bourogne
Study officials:
References:
Clinical trial NCT00142675: Using Peers to Promote Exercise in Older Adults
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Cardiovascular Diseases
Lead sponsor: Stanford University
Sponsor class: OTHER
Collaborators: name: National Heart, Lung, and Blood Institute (NHLBI)
First posted: 2005-09-02
Sex: ALL
Minimum age (years): 50
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Primary purpose: PREVENTION

Brief summary: A randomized controlled trial to evaluate the effects of a 12-month telephone-supervised, home-based physical activity intervention, delivered via health educators versus supervised, trained peers, on physical activity patterns. Inactive men and women ages 50 years and older will be randomly assigned to one of these two programs or to an attention-control arm.

Detailed description: BACKGROUND:

Despite the recognized benefits of regular physical activity, older adults remain among the most inactive segments of the U.S. population. A number of studies have demonstrated the health impact and resultant reduction in chronic disease risk achieved by improving physical activity patterns. Effective telephone-based counseling approaches for promoting and sustaining regular physical activity among older adults have been developed and validated. Such mediated interventions provide a level of individual tailoring and ongoing support to long-term adherence, while allowing for ongoing program delivery that is more flexible, convenient, and potentially lower-cost than face-to face program delivery formats. Telephone-based delivery format also allows for potentially greater reach into segments of the older population that may find it difficult or unappealing to come to community settings on a regular basis.

DESIGN NARRATIVE:

A 12-month randomized trial in which women and men ages 50 years and above living in the San Francisco Bay area who meet medical and physical activity criteria, following a baseline evaluation, be randomized to one of three study arms: telephone-supervised, home-based physical activity instruction via a trained health educator; telephone-supervised, home-based physical activity instruction via a supervised peer facilitator; or an attention-control arm consisting of health educator-based telephone delivery of non-physical activity oriented health information and support. All subjects will have a follow-up evaluation at 6 and 12 months.

Eligibility criteria: Women and men ages 50 years and above of the San Francisco Bay area who are free of any medical condition or disorder that would limit participation in moderate intensity exercise, not hypertensive, stable on all medications, possess English-speaking and reading skills, and are available and able to participate in the evaluations and intervention.

Primary outcomes:
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
References:
Clinical trial NCT06686875: Chronic Abdominal Pain After Laparoscopic Sleeve Gastrectomy
Official title: Assessment of the Prevalence of Persistent Postoperative Pain in Patients Undergoing Laparoscopic Gastrectomy
Study type: OBSERVATIONAL
Overall status: ENROLLING_BY_INVITATION
Conditions: Obesity
Chronic Pain
Abdominal Pain
Keywords: laparoscopic sleeve gastrectomy
chronic postoperative pain
neuropathic pain
Lead sponsor: Medical University of Warsaw
Sponsor class: OTHER
First posted: 2024-11-13
Enrollment: 200
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: CROSS_SECTIONAL
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Patients who underwent surgery at the Department of General Surgery and Transplantology of the Medical University of Warsaw between January 2020 and December 2024

Brief summary: The study aims to evaluate the prevalence of postoperative chronic pain, defined as the persistence of abdominal pain for more than 3 months after laparoscopic sleeve gastrectomy.

Detailed description: The main goal of this study is to determine the incidence of chronic abdominal pain among patients who have undergone laparoscopic sleeve gastrectomy. Patients who underwent this type of surgery at the Department of General Surgery and Transplantology of the Medical University of Warsaw between January 2020 and August 2024 will be qualified for the study. The participants will be asked to complete an online questionnaire, including a pain scale and PainDETECT Questionnaire.

Eligibility criteria: Inclusion Criteria:

* Patients who underwent laparoscopic sleeve gastrectomy 3 months to 5 years earlier

Exclusion Criteria:

* Lack of patient consent to participate in the survey
* No possibility to contact the patient
* Revisional procedures

Primary outcomes:
measure: The presence of chronic abdominal pain after laparoscopic sleeve gastrectomy
timeFrame: Baseline
Secondary outcomes:
measure: PainDETECT Questionnaire score
timeFrame: Baseline
Other outcomes:
Locations:
city: Warsaw
country: Poland
facility: Medical University in Warsaw
Study officials:
References: