Clinical trial NCT02415400: A Study of Apixaban in Patients With Atrial Fibrillation, Not Caused by a Heart Valve Problem, Who Are at Risk for Thrombosis (Blood Clots) Due to Having Had a Recent Coronary Event, Such as a Heart Attack or a Procedure to Open the Vessels of the Heart
Official title: An Open-label, 2 x 2 Factorial, Randomized Controlled, Clinical Trial to Evaluate the Safety of Apixaban vs. Vitamin K Antagonist and Aspirin vs. Aspirin Placebo in Patients With Atrial Fibrillation and Acute Coronary Syndrome or Percutaneous Coronary Intervention
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE4
Conditions: Acute Coronary Syndromes
Lead sponsor: Bristol-Myers Squibb
Sponsor class: INDUSTRY
Collaborators: name: Pfizer
name: Duke Clinical Research Institute
First posted: 2015-04-14
Enrollment: 4614
Sex: ALL
Minimum age (years): 18
Maximum age (years): 95
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: FACTORIAL
Primary purpose: OTHER

Brief summary: The purpose of this study is to determine if Apixaban is safer than a Vitamin K Antagonist given for 6 months in terms of bleeding in patients with an irregular heart beat (atrial fibrillation) and a recent heart attack or a recent procedure to open up a blood vessel in the heart. All patients would also be taking a class of medicines called P2Y12 inhibitors (such as clopidogrel/Plavix) and be treated for up to 6 months. The primary focus will be a comparison of the bleeding risk of Apixaban, with or without aspirin, versus a Vitamin K antagonist, such as warfarin, with or without aspirin.

Detailed description: Patients will be recruited from either inpatient coronary care or general medical units, or recruited from outpatient cardiology offices.

Masking:

Apixaban: Open label.

VKA: Open label.

Acetylsalicylic acid film coated tablet: Double Blinded.

Placebo matching Acetylsalicylic acid film coated tablet: Double Blinded.

Eligibility criteria: For more information regarding BMS clinical trial participation, please visit www.BMSStudyConnect.com

Inclusion Criteria:

* Adults with either active or a history of non-valvular atrial fibrillation or flutter with the planned or existing use of an oral anticoagulant for prophylaxis of thromboembolism. In addition, subjects must have had an acute coronary syndrome or percutaneous coronary intervention with a stent within the prior 14 days
* Planned use of antiplatelet agents for at least 1 to 6 months
* Males and Females ≥ 18 years of age
* Women of childbearing potential must have a negative serum or urine pregnancy test within 24 hours prior to the start of study drug

Exclusion Criteria:

* Conditions other than atrial fibrillation that require chronic anticoagulation. (e.g. prosthetic mechanical heart valve)
* Severe renal insufficiency (serum creatinine \> 2.5 mg/dL or a calculated creatinine clearance \< 30 mL/min
* Patients with a history of intracranial hemorrhage
* Patients have had or will undergo Coronary arterial bypass graft (CABG) for their index acute coronary syndrome (ACS) event
* Patients with known ongoing bleeding and patients with known coagulopathies
* Any contraindications or allergies to VKA, apixaban, or to intended P2Y12 antagonists or to aspirin

Primary outcomes:
measure: The Rate of International Society on Thrombosis and Haemostasis (ISTH) Major or Clinically Relevant Non-Major (CRNM) Bleeding With Apixaban Versus Vitamin K Antagonist (VKA) During the Treatment Period
timeFrame: Approximately 6 months
measure: The Rate of ISTH Major or CRNM Bleeding With Aspirin Versus no Aspirin During the Treatment Period
timeFrame: Approximately 6 months
Secondary outcomes:
measure: Superiority on ISTH Major or CRNM Bleeding for Apixaban Versus VKA
timeFrame: Approximately 6 months
measure: The Rate of All-cause Death or All-cause Rehospitalization With Apixaban Versus VKA
timeFrame: Approximately 6 months
measure: The Rate of All-cause Death or All-cause Rehospitalization With Aspirn Versus no Aspirin
timeFrame: Approximately 6 months
measure: The Rate of the Composite Endpoint of Death or Ischemic Events (Stroke, Myocardial Infarction, Stent Thrombosis, Urgent Revascularization) With Apixaban Versus VKA
timeFrame: Approximately 6 months
measure: The Composite Endpoints of Death and Ischemic Events (Stroke, Myocardial Infarction, Stent Thrombosis, Urgent Revascularization) With Aspirin Versus no Aspirin
timeFrame: Approximately 6 months
Other outcomes:
Locations:
city: Birmingham
country: United States
facility: Cardiovascular Associates of the Southeast, LLC
state: Alabama
city: Birmingham
country: United States
facility: University of Alabama at Birmingham
state: Alabama
city: Phoenix
country: United States
facility: Arizona Heart Rhythm Center
state: Arizona
city: Phoenix
country: United States
facility: Local Institution
state: Arizona
city: Scottsdale
country: United States
facility: Scottsdale Osborn Medical Center
state: Arizona
city: Tucson
country: United States
facility: Southern Arizona VA Health Care System
state: Arizona
city: Little Rock
country: United States
facility: Local Institution
state: Arkansas
city: Phoenix
country: United States
facility: Local Institution
state: Arkansas
city: Alhambra
country: United States
facility: Comprehensive Cardiovascular Specialists
state: California
city: Culver City
country: United States
facility: Local Institution
state: California
city: Fremont
country: United States
facility: Washington Township Medical Foundation
state: California
city: Huntington Beach
country: United States
facility: California Heart Specialist, Inc.
state: California
city: La Jolla
country: United States
facility: Foundation For Cardiovascular Medicine
state: California
city: Long Beach
country: United States
facility: Local Institution
state: California
city: Rancho Mirage
country: United States
facility: Local Institution
state: California
city: San Diego
country: United States
facility: Local Institution
state: California
city: Stockton
country: United States
facility: Manshadi Heart Institute
state: California
city: Torrance
country: United States
facility: Local Institution
state: California
city: Aurora
country: United States
facility: University Of Colorado
state: Colorado
city: Lakewood
country: United States
facility: Colorado Heart and Vascular
state: Colorado
city: Norwalk
country: United States
facility: Local Institution
state: Connecticut
city: Wilmington
country: United States
facility: Local Institution
state: Delaware
city: Altamonte Springs
country: United States
facility: Orlando Heart Specialists
state: Florida
city: Bradenton
country: United States
facility: Local Institution
state: Florida
city: Clearwater
country: United States
facility: Clearwater Cardiovascular and Interventional Consultants
state: Florida
city: Clearwater
country: United States
facility: Local Institution
state: Florida
city: Daytona Beach
country: United States
facility: Daytona Heart Group
state: Florida
city: Fort Lauderdale
country: United States
facility: Local Institution
state: Florida
city: Jacksonville Beach
country: United States
facility: Local Institution
state: Florida
city: Jacksonville
country: United States
facility: Local Institution
state: Florida
city: Jacksonville
country: United States
facility: Local Institution
state: Florida
city: Jupiter
country: United States
facility: Tenet Florida Physician Services
state: Florida
city: Lake Mary
country: United States
facility: Local Institution
state: Florida
city: Miami
country: United States
facility: Local Institution
state: Florida
city: Ocala
country: United States
facility: Mediquest Research
state: Florida
city: Orlando
country: United States
facility: Local Institution
state: Florida
city: Palm Beach Gardens
country: United States
facility: CP Cardiology Partners
state: Florida
city: Saint Petersburg
country: United States
facility: Bayfront Health St. Petersburg
state: Florida
city: Tampa
country: United States
facility: Local Institution
state: Florida
city: Wellington
country: United States
facility: Cardiology Partners
state: Florida
city: Athens
country: United States
facility: Athens Regional Cariology Group
state: Georgia
city: Atlanta
country: United States
facility: Local Institution
state: Georgia
city: Augusta
country: United States
facility: Augusta University
state: Georgia
city: Covington
country: United States
facility: Georgia Heart Specialists
state: Georgia
city: Cumming
country: United States
facility: Local Institution
state: Georgia
city: Tucker
country: United States
facility: Local Institution
state: Georgia
city: Boise
country: United States
facility: Saint Lukes Idaho Cardiology Associates
state: Idaho
city: Fairview Heights
country: United States
facility: Medicoricium, LLC
state: Illinois
city: Jerseyville
country: United States
facility: Gateway Cardiology PC
state: Illinois
city: Normal
country: United States
facility: Advocate Medical Group ? Cardiology and Pulmonology
state: Illinois
city: Olympia Fields
country: United States
facility: South Suburban Cardiology
state: Illinois
city: Bloomington
country: United States
facility: Local Institution
state: Indiana
city: Elkhart
country: United States
facility: Elkhart Clinic LLC
state: Indiana
city: Indianapolis
country: United States
facility: Roudebush VA Medical Center
state: Indiana
city: Richmond
country: United States
facility: Reid Hospital and Health Care Services
state: Indiana
city: Davenport
country: United States
facility: Midwest Cardiovascular Research Foundation
state: Iowa
city: Iowa City
country: United States
facility: University of Iowa Stead Family Children's Hospital
state: Iowa
city: Waterloo
country: United States
facility: Northeast Iowa Family Practice Center
state: Iowa
city: Kansas City
country: United States
facility: Local Institution
state: Kansas
city: Wichita
country: United States
facility: Local Institution
state: Kansas
city: Crestview Hills
country: United States
facility: Saint Elizabeth Healthcare
state: Kentucky
city: Louisville
country: United States
facility: University of Louisville
state: Kentucky
city: Alexandria
country: United States
facility: Alexandria Cardiology Clinic
state: Louisiana
city: Lake Charles
country: United States
facility: Imperial Health
state: Louisiana
city: Minden
country: United States
facility: Local Institution
state: Louisiana
city: Monroe
country: United States
facility: Clinical Trials of America LA LLC - PPDS
state: Louisiana
city: Natick
country: United States
facility: Local Institution
state: Massachusetts
city: Alpena
country: United States
facility: Great Lakes Heart Center of Alpena
state: Michigan
city: Ann Arbor
country: United States
facility: Local Institution
state: Michigan
city: Detroit
country: United States
facility: Henry Ford Hospital
state: Michigan
city: Detroit
country: United States
facility: Local Institution
state: Michigan
city: Lansing
country: United States
facility: Local Institution
state: Michigan
city: Saginaw
country: United States
facility: Covenant Center for the Heart
state: Michigan
city: Minneapolis
country: United States
facility: Metropolitan Cardiology Consultants
state: Minnesota
city: Hattiesburg
country: United States
facility: Hattiesburg Clinic
state: Mississippi
city: Jackson
country: United States
facility: Local Institution
state: Mississippi
city: Tupelo
country: United States
facility: Cardiology Associates Research LLC
state: Mississippi
city: Columbia
country: United States
facility: Missouri Cardiovascular Specialists
state: Missouri
city: Columbia
country: United States
facility: Local Institution
state: Missouri
city: Joplin
country: United States
facility: Freeman Health System
state: Missouri
city: Saint Louis
country: United States
facility: Gateway Cardiology PC
state: Missouri
city: Saint Louis
country: United States
facility: St. Louis Heart and Vascular
state: Missouri
city: Springfield
country: United States
facility: Cox Health Systems
state: Missouri
city: Billings
country: United States
facility: Local Institution
state: Montana
city: Lincoln
country: United States
facility: Bryan Heart Hospital
state: Nebraska
city: Las Vegas
country: United States
facility: HCP Clinical Research LLC
state: Nevada
city: Reno
country: United States
facility: Renown Regional Medical Center.
state: Nevada
city: Linden
country: United States
facility: New Jersey Heart
state: New Jersey
city: Albany
country: United States
facility: Capital Cardiology Associates
state: New York
city: Brooklyn
country: United States
facility: New York-Presbyterian Brooklyn Methodist Hospital
state: New York
city: Brooklyn
country: United States
facility: Local Institution
state: New York
city: Buffalo
country: United States
facility: Buffalo Heart Group LLP
state: New York
city: New York
country: United States
facility: Mount Sinai-St. Lukes
state: New York
city: Poughkeepsie
country: United States
facility: Hudson Valley Cardiovascular Practice, PC
state: New York
city: Asheville
country: United States
facility: Asheville Cardiology Associates PA
state: North Carolina
city: Chapel Hill
country: United States
facility: University of North Carolina School of Medicine
state: North Carolina
city: Durham
country: United States
facility: Durham VA Medical Center
state: North Carolina
city: Durham
country: United States
facility: Duke University Medical Center
state: North Carolina
city: Lenoir
country: United States
facility: Clinical Trials of America-NC, LLC - PPDS
state: North Carolina
city: Lumberton
country: United States
facility: Duke Cardiology and Cardiovascular Surgery of Lumberton
state: North Carolina
city: Wilmington
country: United States
facility: PMG Research of Wilmington
state: North Carolina
city: Canton
country: United States
facility: Aultman Hospital
state: Ohio
city: Columbus
country: United States
facility: Local Institution
state: Ohio
city: Kettering
country: United States
facility: Local Institution
state: Ohio
city: Willoughby
country: United States
facility: Local Institution
state: Ohio
city: Erie
country: United States
facility: Saint Vincent Hospital
state: Pennsylvania
city: Lancaster
country: United States
facility: Heart Group
state: Pennsylvania
city: Newton
country: United States
facility: Mercer Bucks Cardiology
state: Pennsylvania
city: York
country: United States
facility: WellSpan York Hospital
state: Pennsylvania
city: Providence
country: United States
facility: Rhode Island Hospital
state: Rhode Island
city: Columbia
country: United States
facility: Columbia Heart
state: South Carolina
city: Greenville
country: United States
facility: Upstate Cardiology PA
state: South Carolina
city: North Charleston
country: United States
facility: Roper St. Francis Healthcare
state: South Carolina
city: Rock Hill
country: United States
facility: Carolina Cardiology Clinical Research Institute
state: South Carolina
city: Germantown
country: United States
facility: Local Institution
state: Tennessee
city: Jackson
country: United States
facility: Research Associates of Jackson
state: Tennessee
city: Knoxville
country: United States
facility: Cardiovascular Research of Knoxville
state: Tennessee
city: Knoxville
country: United States
facility: Knoxville Health Managment Associates Cardiology PPM LLC
state: Tennessee
city: Oak Ridge
country: United States
facility: Parkway Cardiology Associates PC
state: Tennessee
city: Austin
country: United States
facility: Local Institution
state: Texas
city: Austin
country: United States
facility: Local Institution
state: Texas
city: Dallas
country: United States
facility: Local Institution
state: Texas
city: Fort Sam Houston
country: United States
facility: San Antonio Military Medical Center
state: Texas
city: Houston
country: United States
facility: Angiocardiac Care of Texas PA
state: Texas
city: Houston
country: United States
facility: Local Institution
state: Texas
city: Houston
country: United States
facility: Local Institution
state: Texas
city: Huntsville
country: United States
facility: Grace Research, LLC
state: Texas
city: Huntsville
country: United States
facility: Local Institution
state: Texas
city: Katy
country: United States
facility: Local Institution
state: Texas
city: Lubbock
country: United States
facility: Caprock Cardiac Center Research Institute
state: Texas
city: Plano
country: United States
facility: Local Institution
state: Texas
city: San Antonio
country: United States
facility: Local Institution
state: Texas
city: San Antonio
country: United States
facility: Mercury Medical LLC
state: Texas
city: Sealy
country: United States
facility: Local Institution
state: Texas
city: Sugar Land
country: United States
facility: Local Institution
state: Texas
city: Victoria
country: United States
facility: Victoria Heart and Vascular Center
state: Texas
city: Burlington
country: United States
facility: University of Vermont
state: Vermont
city: Falls Church
country: United States
facility: Virginia Heart
state: Virginia
city: Leesburg
country: United States
facility: Virginia Heart Group Ltd
state: Virginia
city: Richmond
country: United States
facility: CJW Medical Center
state: Virginia
city: Seattle
country: United States
facility: Virginia Mason Medical Center
state: Washington
city: Huntington
country: United States
facility: St Mary's Medical Center
state: West Virginia
city: Wausau
country: United States
facility: Aspirus Research Institute
state: Wisconsin
city: Buenos Aires
country: Argentina
facility: Local Institution
state: BUA
city: Bahia Blanca
country: Argentina
facility: Local Institution
state: Buenos Aires
city: Ciudad Autonoma de Buenos Aires
country: Argentina
facility: Local Institution
state: Buenos Aires
city: Ciudad Autonoma de Buenos Aires
country: Argentina
facility: Local Institution
state: Buenos Aires
city: Coronel Suarez
country: Argentina
facility: Local Institution
state: Buenos Aires
city: Lanus Oeste
country: Argentina
facility: Local Institution
state: Buenos Aires
city: Mar del Plata
country: Argentina
facility: Local Institution
state: Buenos Aires
city: Mar Del Plata
country: Argentina
facility: Local Institution
state: Buenos Aires
city: Quilmes
country: Argentina
facility: Local Institution
state: Buenos Aires
city: Quilmes
country: Argentina
facility: Local Institution
state: Buenos Aires
city: Ramos Mejia
country: Argentina
facility: Local Institution
state: Buenos Aires
city: Ramos Mejia
country: Argentina
facility: Local Institution
state: Buenos Aires
city: Vicente Lopez
country: Argentina
facility: Local Institution
state: Buenos Aires
city: Resistencia
country: Argentina
facility: Local Institution
state: Chaco
city: Ciudad De Cordoba
country: Argentina
facility: Local Institution
state: Cordoba
city: Villa Allende
country: Argentina
facility: Local Institution
state: Cordoba
city: Villa Maria
country: Argentina
facility: Local Institution
state: Cordoba
city: Rosario
country: Argentina
facility: Local Institution
state: Santa FE
city: Rosario
country: Argentina
facility: Local Institution
state: Santa FE
city: Rosario
country: Argentina
facility: Local Institution
state: Santa FE
city: Buenos Aires
country: Argentina
facility: Local Institution
city: Buenos Aires
country: Argentina
facility: Local Institution
city: Buenos Aires
country: Argentina
facility: Local Institution
city: Buenos Aires
country: Argentina
facility: Local Institution
city: Buenos Aires
country: Argentina
facility: Local Institution
city: Buenos Aires
country: Argentina
facility: Local Institution
city: Buenos Aires
country: Argentina
facility: Local Institution
city: Buenos Aires
country: Argentina
facility: Local Institution
city: Buenos Aires
country: Argentina
facility: Local Institution
city: Cordoba
country: Argentina
facility: Local Institution
city: Cordoba
country: Argentina
facility: Local Institution
city: Cordoba
country: Argentina
facility: Local Institution
city: Cordoba
country: Argentina
facility: Local Institution
city: Cordoba
country: Argentina
facility: Local Institution
city: Cordoba
country: Argentina
facility: Local Institution
city: Cordoba
country: Argentina
facility: Local Institution
city: Cordoba
country: Argentina
facility: Local Institution
city: Cordoba
country: Argentina
facility: Local Institution
city: Corrientes
country: Argentina
facility: Local Institution
city: Santa Fe
country: Argentina
facility: Local Institution
city: Santa Fe
country: Argentina
facility: Local Institution
city: Santa Fe
country: Argentina
facility: Local Institution
city: Santiago Del Estero
country: Argentina
facility: Local Institution
city: Concord
country: Australia
facility: Local Institution
state: New South Wales
city: Port Macquarie
country: Australia
facility: Local Institution
state: New South Wales
city: Milton
country: Australia
facility: Local Institution
state: Queensland
city: Elizabeth Vale
country: Australia
facility: Local Institution
state: South Australia
city: Bedford Park
country: Australia
facility: Local Institution
city: Graz
country: Austria
facility: Local Institution
city: Graz
country: Austria
facility: Local Institution
city: Linz
country: Austria
facility: Local Institution
city: Linz
country: Austria
facility: Local Institution
city: Vienna
country: Austria
facility: Local Institution
city: Wien
country: Austria
facility: Local Institution
city: Wien
country: Austria
facility: Local Institution
city: Aalst
country: Belgium
facility: Local Institution
city: Antwerpen
country: Belgium
facility: Local Institution
city: Bonheiden
country: Belgium
facility: Local Institution
city: Brasschaat
country: Belgium
facility: Local Institution
city: Bruxelles
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facility: Local Institution
city: Gent
country: Belgium
facility: Local Institution
city: Ieper
country: Belgium
facility: Local Institution
city: Leuven
country: Belgium
facility: Local Institution
city: Wilrijk
country: Belgium
facility: Local Institution
city: Yvoir
country: Belgium
facility: Local Institution
city: Salvador
country: Brazil
facility: Local Institution
state: Bahia
city: Salvador
country: Brazil
facility: Local Institution
state: Bahia
city: Salvador
country: Brazil
facility: Local Institution
state: Bahia
city: Salvador
country: Brazil
facility: Local Institution
state: Bahia
city: Brasilia
country: Brazil
facility: Local Institution
state: Distrito Federal
city: Colatina
country: Brazil
facility: Local Institution
state: Espirito Santo
city: Aparecida de Goiania
country: Brazil
facility: Local Institution
state: Goias
city: Goiania
country: Brazil
facility: Local Institution
state: Goias
city: Belo Horizonte
country: Brazil
facility: Local Institution
state: Minas Gerais
city: Belo Horizonte
country: Brazil
facility: Local Institution
state: Minas Gerais
city: Uberaba
country: Brazil
facility: Local Institution
state: Minas Gerais
city: Uberlandia
country: Brazil
facility: Local Institution
state: Minas Gerais
city: Campina Grande Do Sul
country: Brazil
facility: Local Institution
state: Parana
city: Londrina
country: Brazil
facility: Local Institution
state: Parana
city: Belem
country: Brazil
facility: Local Institution
state: Para
city: Recife
country: Brazil
facility: Local Institution
state: Pernambuco
city: Recife
country: Brazil
facility: Local Institution
state: Pernambuco
city: Canoas
country: Brazil
facility: Local Institution
state: RIO Grande DO SUL
city: Passo Fundo
country: Brazil
facility: Local Institution
state: RIO Grande DO SUL
city: Porto Alegre
country: Brazil
facility: Local Institution
state: RIO Grande DO SUL
city: Porto Alegre
country: Brazil
facility: Local Institution
state: RIO Grande DO SUL
city: Porto Alegre
country: Brazil
facility: Local Institution
state: RIO Grande DO SUL
city: Porto Alegre
country: Brazil
facility: Local Institution
state: RIO Grande DO SUL
city: Porto Alegre
country: Brazil
facility: Local Institution
state: RIO Grande DO SUL
city: Porto Alegre
country: Brazil
facility: Local Institution
state: RIO Grande DO SUL
city: Blumenau
country: Brazil
facility: Local Institution
state: Santa Catarina
city: Itajai
country: Brazil
facility: Local Institution
state: Santa Catarina
city: Campinas
country: Brazil
facility: Local Institution
state: SAO Paulo
city: Limeira
country: Brazil
facility: Local Institution
state: SAO Paulo
city: Marilia
country: Brazil
facility: Local Institution
state: SAO Paulo
city: S?o Paulo
country: Brazil
facility: Local Institution
state: SAO Paulo
city: S?o Paulo
country: Brazil
facility: Local Institution
state: SAO Paulo
city: S?o Paulo
country: Brazil
facility: Local Institution
state: SAO Paulo
city: Santo Andre
country: Brazil
facility: Local Institution
state: SAO Paulo
city: Sao Jose Do Rio Preto
country: Brazil
facility: Local Institution
state: SAO Paulo
city: Votuporanga
country: Brazil
facility: Local Institution
state: SAO Paulo
city: Rio de Janeiro
country: Brazil
facility: Local Institution
city: Sao Paulo
country: Brazil
facility: Local Institution
city: Sao Paulo
country: Brazil
facility: Local Institution
city: Burgas
country: Bulgaria
facility: Local Institution
city: Dimitrovgrad
country: Bulgaria
facility: Local Institution
city: Haskovo
country: Bulgaria
facility: Local Institution
city: Montana
country: Bulgaria
facility: Local Institution
city: Pazardzhik
country: Bulgaria
facility: Local Institution
city: Pleven
country: Bulgaria
facility: Local Institution
city: Plovdiv
country: Bulgaria
facility: Local Institution
city: Sandanski
country: Bulgaria
facility: Local Institution
city: Smolyan
country: Bulgaria
facility: Local Institution
city: Sofia
country: Bulgaria
facility: Local Institution
city: Sofia
country: Bulgaria
facility: Local Institution
city: Sofia
country: Bulgaria
facility: Local Institution
city: Sofia
country: Bulgaria
facility: Local Institution
city: Sofia
country: Bulgaria
facility: Local Institution
city: Sofia
country: Bulgaria
facility: Local Institution
city: Veliko Tarnova
country: Bulgaria
facility: Local Institution
city: Vidin
country: Bulgaria
facility: Local Institution
city: Edmonton
country: Canada
facility: Local Institution
state: Alberta
city: Edmonton
country: Canada
facility: Local Institution
state: Alberta
city: Edmonton
country: Canada
facility: Local Institution
state: Alberta
city: Kelowna
country: Canada
facility: Local Institution
state: British Columbia
city: New Westminster
country: Canada
facility: Local Institution
state: British Columbia
city: Victoria
country: Canada
facility: Local Institution
state: British Columbia
city: Winnepeg
country: Canada
facility: Local Institution
state: Manitoba
city: Halifax
country: Canada
facility: Local Institution
state: Nova Scotia
city: Cambridge
country: Canada
facility: Local Institution
state: Ontario
city: London
country: Canada
facility: Local Institution
state: Ontario
city: Oshawa
country: Canada
facility: Local Institution
state: Ontario
city: Scarborough
country: Canada
facility: Local Institution
state: Ontario
city: Scarborough
country: Canada
facility: Local Institution
state: Ontario
city: Sudbury
country: Canada
facility: Local Institution
state: Ontario
city: Sudbury
country: Canada
facility: Local Institution
state: Ontario
city: Waterloo
country: Canada
facility: Local Institution
state: Ontario
city: Green Field Park
country: Canada
facility: Local Institution
state: Quebec
city: Laval
country: Canada
facility: Local Institution
state: Quebec
city: Longueuil
country: Canada
facility: Local Institution
state: Quebec
city: Montreal
country: Canada
facility: Local Institution
state: Quebec
city: Sherbrooke
country: Canada
facility: Local Institution
state: Quebec
city: St-Georges, Beauce
country: Canada
facility: Local Institution
state: Quebec
city: St-Jean-sur-Richelieu
country: Canada
facility: Local Institution
state: Quebec
city: St. Jerome
country: Canada
facility: Local Institution
state: Quebec
city: Regina
country: Canada
facility: Local Institution
state: Saskatchewan
city: Montreal
country: Canada
facility: Local Institution
city: Santiago
country: Chile
facility: Local Institution
state: Metropolitana
city: Barranquilla
country: Colombia
facility: Local Institution
city: Barranquilla
country: Colombia
facility: Local Institution
city: Bogota
country: Colombia
facility: Local Institution
city: Cali
country: Colombia
facility: Local Institution
city: Espinal
country: Colombia
facility: Local Institution
city: Medellin
country: Colombia
facility: Local Institution
city: Cakovec
country: Croatia
facility: Local Institution
city: Dubrovnik
country: Croatia
facility: Local Institution
city: Karlovac
country: Croatia
facility: Local Institution
city: Krapinske toplice
country: Croatia
facility: Local Institution
city: Opatija
country: Croatia
facility: Local Institution
city: Osijek
country: Croatia
facility: Local Institution
city: Rijeka
country: Croatia
facility: Local Institution
city: Sibenik
country: Croatia
facility: Local Institution
city: Slavonski Brod
country: Croatia
facility: Local Institution
city: Virovitica
country: Croatia
facility: Local Institution
city: Zabok
country: Croatia
facility: Local Institution
city: Zadar
country: Croatia
facility: Local Institution
city: Zagreb
country: Croatia
facility: Local Institution
city: Prague 8
country: Czechia
facility: Local Institution
city: Praha 2
country: Czechia
facility: Local Institution
city: Praha 5
country: Czechia
facility: Local Institution
city: Tabor
country: Czechia
facility: Local Institution
city: Usti Nad Orlici
country: Czechia
facility: Local Institution
city: Zlin
country: Czechia
facility: Local Institution
city: Aabenraa
country: Denmark
facility: Local Institution
city: Aarhus
country: Denmark
facility: Local Institution
city: Copenhagen
country: Denmark
facility: Local Institution
city: Frederiksburg
country: Denmark
facility: Local Institution
city: Hellerup
country: Denmark
facility: Local Institution
city: Hillerod
country: Denmark
facility: Local Institution
city: Holb?k
country: Denmark
facility: Local Institution
city: Hvidovre
country: Denmark
facility: Local Institution
city: Randers
country: Denmark
facility: Local Institution
city: Roskilde
country: Denmark
facility: Local Institution
city: Slagelse
country: Denmark
facility: Local Institution
city: Besancon
country: France
facility: Local Institution
city: Caen
country: France
facility: Local Institution
city: Chambray-les-Tours
country: France
facility: Local Institution
city: Le Coudray
country: France
facility: Local Institution
city: Lyon
country: France
facility: Local Institution
city: Marseille
country: France
facility: Local Institution
city: Nimes
country: France
facility: Local Institution
city: Pau
country: France
facility: Local Institution
city: Pessac
country: France
facility: Local Institution
city: Toulouse
country: France
facility: Local Institution
city: Bad Friedrichshall
country: Germany
facility: Local Institution
city: Bad Homburg
country: Germany
facility: Local Institution
city: Bad Homburg
country: Germany
facility: Local Institution
city: Berlin
country: Germany
facility: Local Institution
city: Berlin
country: Germany
facility: Local Institution
city: Berlin
country: Germany
facility: Local Institution
city: Bielefeld
country: Germany
facility: Local Institution
city: Brandenburg
country: Germany
facility: Local Institution
city: Bremen
country: Germany
facility: Local Institution
city: Chemnitz
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country: Germany
facility: Local Institution
city: Dresden
country: Germany
facility: Local Institution
city: Dresden
country: Germany
facility: Local Institution
city: Erfurt
country: Germany
facility: Local Institution
city: Erfurt
country: Germany
facility: Local Institution
city: Erlangen
country: Germany
facility: Local Institution
city: Essen
country: Germany
facility: Local Institution
city: Frankfurt am Main
country: Germany
facility: Local Institution
city: Freiburg
country: Germany
facility: Local Institution
city: Gottingen
country: Germany
facility: Local Institution
city: Greifswald
country: Germany
facility: Local Institution
city: Hamburg
country: Germany
facility: Local Institution
city: Hamburg
country: Germany
facility: Local Institution
city: Hansestadt Stendal
country: Germany
facility: Local Institution
city: Hennigsdorf
country: Germany
facility: Local Institution
city: Hoyerswerda
country: Germany
facility: Local Institution
city: Jena
country: Germany
facility: Local Institution
city: Karlsbad
country: Germany
facility: Local Institution
city: Kassel
country: Germany
facility: Local Institution
city: Koln
country: Germany
facility: Local Institution
city: Lahr
country: Germany
facility: Local Institution
city: Leipzig
country: Germany
facility: Local Institution
city: Limburg
country: Germany
facility: Local Institution
city: Ludenscheid
country: Germany
facility: Local Institution
city: Luebeck
country: Germany
facility: Local Institution
city: Magdeburg
country: Germany
facility: Local Institution
city: Mainz
country: Germany
facility: Local Institution
city: Mannheim
country: Germany
facility: Local Institution
city: Neuss
country: Germany
facility: Local Institution
city: Papenburg
country: Germany
facility: Local Institution
city: Regensburg
country: Germany
facility: Local Institution
city: Rostock
country: Germany
facility: Local Institution
city: Straubing
country: Germany
facility: Local Institution
city: Tubingen
country: Germany
facility: Local Institution
city: Ulm
country: Germany
facility: Local Institution
city: Villingen-Schwenningen
country: Germany
facility: Local Institution
city: Weiden i.d.OPf.
country: Germany
facility: Local Institution
city: Worms
country: Germany
facility: Local Institution
city: Wurzburg
country: Germany
facility: Local Institution
city: Baja
country: Hungary
facility: Local Institution
state: Bacs-kiskun
city: Bekescsaba
country: Hungary
facility: Local Institution
city: Budapest
country: Hungary
facility: Local Institution
city: Budapest
country: Hungary
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city: Budapest
country: Hungary
facility: Local Institution
city: Budapest
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facility: Local Institution
city: Budapest
country: Hungary
facility: Local Institution
city: Budapest
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facility: Local Institution
city: Keszthely
country: Hungary
facility: Local Institution
city: Mosonmagyarovar
country: Hungary
facility: Local Institution
city: Pecs
country: Hungary
facility: Local Institution
city: Pecs
country: Hungary
facility: Local Institution
city: Szeged
country: Hungary
facility: Local Institution
city: Szekszard
country: Hungary
facility: Local Institution
city: Szolnok
country: Hungary
facility: Local Institution
city: Ahmedabad
country: India
facility: Local Institution
state: Gujarat
city: Bangalore
country: India
facility: Local Institution
state: Karnataka
city: Amritsar
country: India
facility: Local Institution
city: Jaipur,
country: India
facility: Local Institution
city: Lucknow
country: India
facility: Local Institution
city: Madurai
country: India
facility: Local Institution
city: Mangalore
country: India
facility: Local Institution
city: New Delhi
country: India
facility: Local Institution
city: New Delhi
country: India
facility: Local Institution
city: Noida
country: India
facility: Local Institution
city: Shivamogga
country: India
facility: Local Institution
city: Vadodara
country: India
facility: Local Institution
city: Vijayawada
country: India
facility: Local Institution
city: Afula
country: Israel
facility: Local Institution
city: Ashkelon
country: Israel
facility: Local Institution
city: Hadera
country: Israel
facility: Local Institution
city: Haifa
country: Israel
facility: Local Institution
city: Haifa
country: Israel
facility: Local Institution
city: Haifa
country: Israel
facility: Local Institution
city: Herzliya
country: Israel
facility: Local Institution
city: Holon
country: Israel
facility: Local Institution
city: Jerusalem
country: Israel
facility: Local Institution
city: Ramat-Gan
country: Israel
facility: Local Institution
city: Rehovot
country: Israel
facility: Local Institution
city: Safed
country: Israel
facility: Local Institution
city: Tel Aviv
country: Israel
facility: Local Institution
city: Tiberias
country: Israel
facility: Local Institution
city: Grosseto
country: Italy
facility: Local Institution
city: Busan
country: Korea, Republic of
facility: Local Institution
city: Changwon
country: Korea, Republic of
facility: Local Institution
city: Daegu
country: Korea, Republic of
facility: Local Institution
city: Daegu
country: Korea, Republic of
facility: Local Institution
city: Daejeon
country: Korea, Republic of
facility: Local Institution
city: Gwang Ju
country: Korea, Republic of
facility: Local Institution
city: Incheon
country: Korea, Republic of
facility: Local Institution
city: Seongnam-si
country: Korea, Republic of
facility: Local Institution
city: Seoul
country: Korea, Republic of
facility: Local Institution
city: Seoul
country: Korea, Republic of
facility: Local Institution
city: Seoul
country: Korea, Republic of
facility: Local Institution
city: Seoul
country: Korea, Republic of
facility: Local Institution
city: Torreon
country: Mexico
facility: Local Institution
state: Coahuila
city: Leon
country: Mexico
facility: Local Institution
state: Guanajuato
city: Guadalajara
country: Mexico
facility: Local Institution
state: Jalisco
city: Monterrey
country: Mexico
facility: Local Institution
state: Nuevo LEON
city: San Juan del Rio
country: Mexico
facility: Local Institution
state: Queretaro
city: Queretaro
country: Mexico
facility: Local Institution
state: QUE
city: Culiacan
country: Mexico
facility: Local Institution
state: Sinaloa
city: Aguascalientes
country: Mexico
facility: Local Institution
city: Durango
country: Mexico
facility: Local Institution
city: Puebla
country: Mexico
facility: Local Institution
city: San Luis Potosi
country: Mexico
facility: Local Institution
city: San Luis Potosi
country: Mexico
facility: Local Institution
city: Tlalnepantla De Baz
country: Mexico
facility: Local Institution
city: Veracruz
country: Mexico
facility: Local Institution
city: Amsterdam
country: Netherlands
facility: Local Institution
city: Amsterdam
country: Netherlands
facility: Local Institution
city: Arnhem
country: Netherlands
facility: Local Institution
city: Breda
country: Netherlands
facility: Local Institution
city: Ede
country: Netherlands
facility: Local Institution
city: Groningen
country: Netherlands
facility: Local Institution
city: Hardenberg
country: Netherlands
facility: Local Institution
city: Maastricht
country: Netherlands
facility: Local Institution
city: Nieuwegein
country: Netherlands
facility: Local Institution
city: Rotterdam
country: Netherlands
facility: Local Institution
city: Tilburg
country: Netherlands
facility: Local Institution
city: Uden
country: Netherlands
facility: Local Institution
city: Bod?
country: Norway
facility: Local Institution
city: Oslo
country: Norway
facility: Local Institution
city: Oslo
country: Norway
facility: Local Institution
city: Skien
country: Norway
facility: Local Institution
city: Stavanger
country: Norway
facility: Local Institution
city: Tromso
country: Norway
facility: Local Institution
city: Miraflores
country: Peru
facility: Local Institution
state: Lima
city: Callao
country: Peru
facility: Local Institution
city: Callao
country: Peru
facility: Local Institution
city: Cusco
country: Peru
facility: Local Institution
city: Lima
country: Peru
facility: Local Institution
city: Lima
country: Peru
facility: Local Institution
city: Poznan
country: Poland
facility: Local Institution
state: Wielkopolskie
city: Bialystok
country: Poland
facility: Local Institution
city: Bydgoszcz
country: Poland
facility: Local Institution
city: Bytom
country: Poland
facility: Local Institution
city: Chojnice
country: Poland
facility: Local Institution
city: Gdynia
country: Poland
facility: Local Institution
city: Gdynia
country: Poland
facility: Local Institution
city: Katowice
country: Poland
facility: Local Institution
city: Kielce
country: Poland
facility: Local Institution
city: Krakow
country: Poland
facility: Local Institution
city: Krakow
country: Poland
facility: Local Institution
city: Krakow
country: Poland
facility: Local Institution
city: Lodz
country: Poland
facility: Local Institution
city: Lodz
country: Poland
facility: Local Institution
city: Lodz
country: Poland
facility: Local Institution
city: Lubin
country: Poland
facility: Local Institution
city: Opole
country: Poland
facility: Local Institution
city: Plock
country: Poland
facility: Local Institution
city: Siemianowice Slaskie
country: Poland
facility: Local Institution
city: Torun
country: Poland
facility: Local Institution
city: Warszawa
country: Poland
facility: Local Institution
city: Warszawa
country: Poland
facility: Local Institution
city: Wloclawek
country: Poland
facility: Local Institution
city: Wroclaw
country: Poland
facility: Local Institution
city: Wroclaw
country: Poland
facility: Local Institution
city: Almada
country: Portugal
facility: Local Institution
city: Aveiro
country: Portugal
facility: Local Institution
city: Braga
country: Portugal
facility: Local Institution
city: Coimbra
country: Portugal
facility: Local Institution
city: Covilha
country: Portugal
facility: Local Institution
city: Guimar?es
country: Portugal
facility: Local Institution
city: Leiria
country: Portugal
facility: Local Institution
city: Lisbon
country: Portugal
facility: Local Institution
city: Senhora De Hora, Matosinhos
country: Portugal
facility: Local Institution
city: Vila Real
country: Portugal
facility: Local Institution
city: Caguas
country: Puerto Rico
facility: Local Institution
city: Baia Mare
country: Romania
facility: Local Institution
city: Brasov
country: Romania
facility: Local Institution
city: Bucharest
country: Romania
facility: Local Institution
city: Bucharest
country: Romania
facility: Local Institution
city: Cluj-Napoca
country: Romania
facility: Local Institution
city: Cluj-Napoca
country: Romania
facility: Local Institution
city: Craiova
country: Romania
facility: Local Institution
city: Oradea
country: Romania
facility: Local Institution
city: Pitesti
country: Romania
facility: Local Institution
city: Sibiu
country: Romania
facility: Local Institution
city: Targoviste
country: Romania
facility: Local Institution
city: Targu Mures
country: Romania
facility: Local Institution
city: Timisoara
country: Romania
facility: Local Institution
city: Timisoara
country: Romania
facility: Local Institution
city: Tirgu Mures
country: Romania
facility: Local Institution
city: Ekaterinburg
country: Russian Federation
facility: Local Institution
city: Gatchina
country: Russian Federation
facility: Local Institution
city: Kazan
country: Russian Federation
facility: Local Institution
city: Krasnodar
country: Russian Federation
facility: Local Institution
city: Krasnodar
country: Russian Federation
facility: Local Institution
city: Moscow
country: Russian Federation
facility: Local Institution
city: Moscow
country: Russian Federation
facility: Local Institution
city: Moscow
country: Russian Federation
facility: Local Institution
city: Moscow
country: Russian Federation
facility: Local Institution
city: Novosibirsk
country: Russian Federation
facility: Local Institution
city: Novosibirsk
country: Russian Federation
facility: Local Institution
city: Saint Petersburg
country: Russian Federation
facility: Local Institution
city: Samara
country: Russian Federation
facility: Local Institution
city: Saratov
country: Russian Federation
facility: Local Institution
city: Saratov
country: Russian Federation
facility: Local Institution
city: Sochi
country: Russian Federation
facility: Local Institution
city: St. Petersburg
country: Russian Federation
facility: Local Institution
city: St. Petersburg
country: Russian Federation
facility: Local Institution
city: St. Petersburg
country: Russian Federation
facility: Local Institution
city: St. Petersburg
country: Russian Federation
facility: Local Institution
city: St. Petersburg
country: Russian Federation
facility: Local Institution
city: Tyumen
country: Russian Federation
facility: Local Institution
city: Tyumen
country: Russian Federation
facility: Local Institution
city: Belgarde
country: Serbia
facility: Local Institution
city: Belgrade
country: Serbia
facility: Local Institution
city: Belgrade
country: Serbia
facility: Local Institution
city: Nis
country: Serbia
facility: Local Institution
city: Sremska Kamenica
country: Serbia
facility: Local Institution
city: Uzice
country: Serbia
facility: Local Institution
city: Banska Bystrica
country: Slovakia
facility: Local Institution
city: Bardejov
country: Slovakia
facility: Local Institution
city: Bratislava
country: Slovakia
facility: Local Institution
city: Bratislava
country: Slovakia
facility: Local Institution
city: Brezno
country: Slovakia
facility: Local Institution
city: Kosice
country: Slovakia
facility: Local Institution
city: Kosice
country: Slovakia
facility: Local Institution
city: Kosice
country: Slovakia
facility: Local Institution
city: Nitra
country: Slovakia
facility: Local Institution
city: Spisska Nova Ves
country: Slovakia
facility: Local Institution
city: Trebisov
country: Slovakia
facility: Local Institution
city: Trencin
country: Slovakia
facility: Local Institution
city: Majadahonda
country: Spain
facility: Local Institution
state: Madrid
city: Alicante
country: Spain
facility: Local Institution
city: Barcelona
country: Spain
facility: Local Institution
city: Cordoba
country: Spain
facility: Local Institution
city: Huelva
country: Spain
facility: Local Institution
city: Madrid
country: Spain
facility: Local Institution
city: Madrid
country: Spain
facility: Local Institution
city: Madrid
country: Spain
facility: Local Institution
city: Madrid
country: Spain
facility: Local Institution
city: Malaga
country: Spain
facility: Local Institution
city: Marbella
country: Spain
facility: Local Institution
city: Palma de Mallorca
country: Spain
facility: Local Institution
city: San Sebastian
country: Spain
facility: Local Institution
city: Valencia
country: Spain
facility: Local Institution
city: Valencia
country: Spain
facility: Local Institution
city: Eskilstuna
country: Sweden
facility: Local Institution
city: Goteborg
country: Sweden
facility: Local Institution
city: Jonkoping
country: Sweden
facility: Local Institution
city: Ostersund
country: Sweden
facility: Local Institution
city: Skelleftea
country: Sweden
facility: Local Institution
city: Stockholm
country: Sweden
facility: Local Institution
city: Uppsala
country: Sweden
facility: Local Institution
city: Bern
country: Switzerland
facility: Local Institution
city: Geneva
country: Switzerland
facility: Local Institution
city: Winterthur
country: Switzerland
facility: Local Institution
city: Cherkasy
country: Ukraine
facility: Local Institution
city: Chernivtsi
country: Ukraine
facility: Local Institution
city: Dnipropetrovsk
country: Ukraine
facility: Local Institution
city: Ivano-Frankivsk
country: Ukraine
facility: Local Institution
city: Kharkiv
country: Ukraine
facility: Local Institution
city: Kharkiv
country: Ukraine
facility: Local Institution
city: Kharkiv
country: Ukraine
facility: Local Institution
city: Kyiv
country: Ukraine
facility: Local Institution
city: Kyiv
country: Ukraine
facility: Local Institution
city: Kyiv
country: Ukraine
facility: Local Institution
city: Lutsk
country: Ukraine
facility: Local Institution
city: Lutsk
country: Ukraine
facility: Local Institution
city: Mykolaiv
country: Ukraine
facility: Local Institution
city: Odesa
country: Ukraine
facility: Local Institution
city: Uzhhorod
country: Ukraine
facility: Local Institution
city: Vinnytsia
country: Ukraine
facility: Local Institution
city: Vinnytsia
country: Ukraine
facility: Local Institution
city: Zhaporizhzhya
country: Ukraine
facility: Local Institution
city: Bournemouth
country: United Kingdom
facility: Local Institution
state: Dorset
city: Kirkcaldy
country: United Kingdom
facility: Local Institution
state: Fife
city: Stevenage
country: United Kingdom
facility: Local Institution
state: Hertfordshire
city: Liverpool
country: United Kingdom
facility: Local Institution
state: Merseyside
city: Northampton
country: United Kingdom
facility: Local Institution
state: Northamptonshire
city: Doncaster
country: United Kingdom
facility: Local Institution
state: South Yorkshire
city: Sheffield
country: United Kingdom
facility: Local Institution
state: South Yorkshire
city: Birmingham
country: United Kingdom
facility: Local Institution
city: Dudley, West Midlands
country: United Kingdom
facility: Local Institution
city: Dundee
country: United Kingdom
facility: Local Institution
city: Wolverhampton
country: United Kingdom
facility: Local Institution
city: Christiansted
country: Virgin Islands (U.S.)
facility: Local Institution
Study officials:
affiliation: Bristol-Myers Squibb
name: Bristol-Myers Squibb
role: STUDY_DIRECTOR
References:
citation: Bahit MC, Vora AN, Li Z, Wojdyla DM, Thomas L, Goodman SG, Aronson R, Jordan JD, Kolls BJ, Dombrowski KE, Vinereanu D, Halvorsen S, Berwanger O, Windecker S, Mehran R, Granger CB, Alexander JH, Lopes RD. Apixaban or Warfarin and Aspirin or Placebo After Acute Coronary Syndrome or Percutaneous Coronary Intervention in Patients With Atrial Fibrillation and Prior Stroke: A Post Hoc Analysis From the AUGUSTUS Trial. JAMA Cardiol. 2022 Jul 1;7(7):682-689. doi: 10.1001/jamacardio.2022.1166.
citation: Welsh RC, Dehghani P, Lopes R, Wojdyla DM, Aronson R, Granger CB, Windecker S, Vora AN, Vinereanu D, Halvorsen S, Parkhomenko A, Mehran R, Alexander JH, Goodman S. Impact of prior oral anticoagulant use and outcomes on patients from secondary analysis in the AUGUSTUS trial. Open Heart. 2022 Feb;9(1):e001892. doi: 10.1136/openhrt-2021-001892.
citation: Harskamp RE, Fanaroff AC, Lopes RD, Wojdyla DM, Goodman SG, Thomas LE, Aronson R, Windecker S, Mehran R, Granger CB, Alexander JH. Antithrombotic Therapy in Patients With Atrial Fibrillation After Acute Coronary Syndromes or Percutaneous Intervention. J Am Coll Cardiol. 2022 Feb 8;79(5):417-427. doi: 10.1016/j.jacc.2021.11.035.
citation: Hijazi Z, Alexander JH, Li Z, Wojdyla DM, Mehran R, Granger CB, Parkhomenko A, Bahit MC, Windecker S, Aronson R, Berwanger O, Halvorsen S, de Waha-Thiele S, Sinnaeve P, Darius H, Storey RF, Lopes RD. Apixaban or Vitamin K Antagonists and Aspirin or Placebo According to Kidney Function in Patients With Atrial Fibrillation After Acute Coronary Syndrome or Percutaneous Coronary Intervention: Insights From the AUGUSTUS Trial. Circulation. 2021 Mar 23;143(12):1215-1223. doi: 10.1161/CIRCULATIONAHA.120.051020. Epub 2021 Jan 19.
citation: Alexander JH, Wojdyla D, Vora AN, Thomas L, Granger CB, Goodman SG, Aronson R, Windecker S, Mehran R, Lopes RD. Risk/Benefit Tradeoff of Antithrombotic Therapy in Patients With Atrial Fibrillation Early and Late After an Acute Coronary Syndrome or Percutaneous Coronary Intervention: Insights From AUGUSTUS. Circulation. 2020 May 19;141(20):1618-1627. doi: 10.1161/CIRCULATIONAHA.120.046534. Epub 2020 Mar 29.
citation: Lopes RD, Leonardi S, Wojdyla DM, Vora AN, Thomas L, Storey RF, Vinereanu D, Granger CB, Goodman SG, Aronson R, Windecker S, Thiele H, Valgimigli M, Mehran R, Alexander JH. Stent Thrombosis in Patients With Atrial Fibrillation Undergoing Coronary Stenting in the AUGUSTUS Trial. Circulation. 2020 Mar 3;141(9):781-783. doi: 10.1161/CIRCULATIONAHA.119.044584. Epub 2019 Nov 11. No abstract available.
citation: Windecker S, Lopes RD, Massaro T, Jones-Burton C, Granger CB, Aronson R, Heizer G, Goodman SG, Darius H, Jones WS, Aschermann M, Brieger D, Cura F, Engstrom T, Fridrich V, Halvorsen S, Huber K, Kang HJ, Leiva-Pons JL, Lewis BS, Malaga G, Meneveau N, Merkely B, Milicic D, Morais J, Potpara TS, Raev D, Sabate M, de Waha-Thiele S, Welsh RC, Xavier D, Mehran R, Alexander JH; AUGUSTUS Investigators. Antithrombotic Therapy in Patients With Atrial Fibrillation and Acute Coronary Syndrome Treated Medically or With Percutaneous Coronary Intervention or Undergoing Elective Percutaneous Coronary Intervention: Insights From the AUGUSTUS Trial. Circulation. 2019 Dec 3;140(23):1921-1932. doi: 10.1161/CIRCULATIONAHA.119.043308. Epub 2019 Sep 26.
citation: Lopes RD, Heizer G, Aronson R, Vora AN, Massaro T, Mehran R, Goodman SG, Windecker S, Darius H, Li J, Averkov O, Bahit MC, Berwanger O, Budaj A, Hijazi Z, Parkhomenko A, Sinnaeve P, Storey RF, Thiele H, Vinereanu D, Granger CB, Alexander JH; AUGUSTUS Investigators. Antithrombotic Therapy after Acute Coronary Syndrome or PCI in Atrial Fibrillation. N Engl J Med. 2019 Apr 18;380(16):1509-1524. doi: 10.1056/NEJMoa1817083. Epub 2019 Mar 17.
citation: Lopes RD, Vora AN, Liaw D, Granger CB, Darius H, Goodman SG, Mehran R, Windecker S, Alexander JH. An open-Label, 2 x 2 factorial, randomized controlled trial to evaluate the safety of apixaban vs. vitamin K antagonist and aspirin vs. placebo in patients with atrial fibrillation and acute coronary syndrome and/or percutaneous coronary intervention: Rationale and design of the AUGUSTUS trial. Am Heart J. 2018 Jun;200:17-23. doi: 10.1016/j.ahj.2018.03.001. Epub 2018 Mar 9.