Clinical trial NCT04054570: The Geneva Lake Study Update : An Overview of Home Non-Invasive Ventilation 15 Years Later
Official title: The Geneva Lake Study Update : An Overview of Home Non-Invasive Ventilation 15 Years Later
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Home Non-Invasive Ventilation
Lead sponsor: University Hospital, Geneva
Sponsor class: OTHER
First posted: 2019-08-13
Enrollment: 947
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: OTHER
Time perspective: CROSS_SECTIONAL
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Patients of all age undergoing long term home NIV for at least 3 months and living in the Cantons of Geneva or Vaud

Brief summary: A multicenter cross-sectional observational study was conducted in the counties of Geneva and Vaud (1'271'957 inhabitants in 2016 and 1'288'090 inhabitants in 2017 ) and included all subjects under home NIV followed by the two university hospitals of Geneva and Lausanne (HUG and CHUV), one private regional general hospital (La Tour Hospital), one pulmonary rehabilitation center (Rolle Hospital) and 38 pulmonologists in private practice (for a total of 43, 18 in Geneva and 20 in Vaud). In Switzerland home NIV can be prescribed, initiated and followed by a pulmonologist in private practice without referring to a hospital center. The coordinating institution for this project was the Geneva University Hospital (HUG).

The investigator's goals were to update the prevalence of home NIV, the description of the population involved, the devices used, their settings, compliance, and a large array of technical data to provide a complete photography of home NIV in an area with 30 years of experience in this field. We also aimed to collect data regarding pursuit or interruption of NIV and survival during observation period.


Eligibility criteria: Inclusion Criteria:

* All patients aged over 18 years old undergoing long term home NIV for at least 3 months and living in the Cantons of Geneva or Vaud were eligible for the study.

Exclusion Criteria:

* The only exclusion criteria was invasive ventilation (tracheostomy).

Primary outcomes:
measure: Diagnosis
timeFrame: 01.06.2016-10.07.2018
Secondary outcomes:
measure: Baseline characteristics
timeFrame: 01.06.2016-10.07.2018
measure: Survival
timeFrame: 01.06.2016-01.05.2021
measure: Leaks
timeFrame: 01.06.2016-10.07.2018
measure: Implementation of NIV
timeFrame: 01.06.2016-10.07.2018
measure: Follow-up modalities
timeFrame: 01.06.2016-10.07.2018
measure: Ventilators
timeFrame: 01.06.2016-10.07.2018
measure: Prevalence of home non invasive ventilation (NIV)
timeFrame: 01.06.2016-10.07.2018
measure: Barometric and volumetric ventilation versus adaptive servo-ventilation (ASV)
timeFrame: 01.06.2016-10.07.2018
measure: Medical follow-up
timeFrame: 01.06.2016-10.07.2018
Other outcomes:
Locations:
Study officials:
References:
citation: Janssens JP, Derivaz S, Breitenstein E, De Muralt B, Fitting JW, Chevrolet JC, Rochat T. Changing patterns in long-term noninvasive ventilation: a 7-year prospective study in the Geneva Lake area. Chest. 2003 Jan;123(1):67-79. doi: 10.1378/chest.123.1.67.
citation: Cantero C, Adler D, Pasquina P, Uldry C, Egger B, Prella M, Younossian AB, Poncet A, Soccal-Gasche P, Pepin JL, Janssens JP. Adaptive Servo-Ventilation: A Comprehensive Descriptive Study in the Geneva Lake Area. Front Med (Lausanne). 2020 Apr 3;7:105. doi: 10.3389/fmed.2020.00105. eCollection 2020.
citation: Cantero C, Adler D, Pasquina P, Uldry C, Egger B, Prella M, Younossian AB, Soccal PM, Pepin JL, Janssens JP. Long-Term Noninvasive Ventilation in the Geneva Lake Area: Indications, Prevalence, and Modalities. Chest. 2020 Jul;158(1):279-291. doi: 10.1016/j.chest.2020.02.064. Epub 2020 Mar 31.