Clinical trial NCT06952166: Understanding the Psychological Benefits and Neurophysiological Mechanisms of Qigong in Older Adults
Official title: Understanding the Psychological Benefits and Neurophysiological Mechanisms of Qigong in Older Adults
Study type: INTERVENTIONAL
Overall status: NOT_YET_RECRUITING
Phase: NA
Conditions: Qigong
Lead sponsor: The Hong Kong Polytechnic University
Sponsor class: OTHER
First posted: 2025-04-30
Enrollment: 180
Sex: ALL
Minimum age (years): 60
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: SUPPORTIVE_CARE

Brief summary: One goal of the study is to evaluate the efficacy of qigong to alleviate depressive symptoms and enhance cognitive function in comparison to mindfulness-based intervention, physical exercise, and waitlist control. The other goal is to explore the changes in neurobiological markers that may explain the qigong-related effects on depressive symptoms and cognitive function. The main research questions are:

* Is the 12-week qigong training more effective than mindfulness-based intervention, physical exercise, and waitlist control to alleviate depressive symptoms?
* Is the 12-week qigong training more effective than mindfulness-based intervention, physical exercise, and waitlist control to enhance cognitive function?

Participants are older adults aged 60 or above. They were randomly assigned to qigong training, mindfulness training, physical exercise training, or wait-list which all last for 12 weeks. Their changes before and after the 12-week period in depressive symptoms, neurobiological markers, and cognitive functions are assessed.


Eligibility criteria: Inclusion Criteria:

* 60 years or older;
* With mild or severer levels of depressive symptoms as indicated by the Geriatric Depression Scale (GDS-8) scores of 5 or above, or Depression Anxiety and Stress Scale-21 (DASS-21) depression subscale scores of 4 or above
* Self-identified as physically stable and without life-threatening diseases.
* Be able to communicate in Cantonese or Mandarin.

Exclusion Criteria:

* Have a history of practicing or receiving training of any form of mind-body or regular exercises (including tai chi, yoga, and qigong, or regular physical activity \> 3 times/week) during the month prior to intervention
* Have changed medications or the dose of medications prescribed for their health condition in the one month prior to study enrollment
* Have severe cognitive or language impairment based on the assessment with Montreal Cognitive Assessment (MoCA)
* Taking medication or undergoing electroconvulsive therapy, psychotherapy, or psychoeducation for a psychological or psychiatric condition
* Unable to demonstrate satisfactory standing balance

Primary outcomes:
measure: Depressive symptoms
timeFrame: Baseline and post-intervention (12 weeks after baseline)
measure: Global cognitive function
timeFrame: Baseline and post-intervention (12 weeks after baseline)
Secondary outcomes:
measure: Serum adiponectin
timeFrame: Baseline and post-intervention (12 weeks after baseline)
measure: Serum BDNF
timeFrame: Baseline and post-intervention (12 weeks after baseline)
measure: Salivary cortisol
timeFrame: Baseline and post-intervention (12 weeks after baseline)
measure: Attention
timeFrame: Baseline and post-intervention (12 weeks after baseline)
measure: Inhibitory control
timeFrame: Baseline and post-intervention (12 weeks after baseline)
measure: Working memory
timeFrame: Baseline and post-intervention (12 weeks after baseline)
measure: ERP N2 amplitude
timeFrame: Baseline and post-intervention (12 weeks after baseline)
measure: ERP P3 amplitude
timeFrame: Baseline and post-intervention (12 weeks after baseline)
measure: Hand grip strength
timeFrame: Baseline and post-intervention (12 weeks after baseline)
measure: Affect
timeFrame: Baseline and post-intervention (12 weeks after baseline)
Other outcomes:
Locations:
city: Kowloon
country: Hong Kong
facility: Hong Kong Polytechnic University, Department of Rehabilitation Sciences
Study officials:
References: