louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT06949917: The Effect of Body Mass Index on Taste Perception,Salivary Hormones and Oral Health Status
Official title: Taste Perception,Oral Health Status and Selectied Salivary Hormones in Relation to Body Mass Index Among Agroup of Iraqi Adolescent Girls.
Study type: OBSERVATIONAL
Overall status: NOT_YET_RECRUITING
Conditions: Oral Health
Tast Perference
Lead sponsor: Al-Mustansiriyah University
Sponsor class: OTHER
First posted: 2025-04-29
Enrollment: 90
Sex: FEMALE
Minimum age (years): 16
Maximum age (years): 17
Standard ages: CHILD
Accepts healthy volunteers: yes
Observational model: CASE_CROSSOVER
Time perspective: CROSS_SECTIONAL
Sampling method: NON_PROBABILITY_SAMPLE
Study population: female adolesent girls 16-17 years old

Brief summary: the goal of the study is to test the effect of body mass index on adolesent Iraqi student girls by measuring salivary hormones (ghrelin,leptin,resistin)and measuring oral health by plague index score() and taste perception score () 90 female subject will be enrolled in this study between 16-17 years old,30 subjects with normal body weight ,30 subject overweight ,and 30 subject with obeiece group catogerize by body mass index according to age.

the methed of the study is by taking Saliva sample from the subject , taste perception score and oral health measure.


Eligibility criteria: Inclusion Criteria:

* female
* 16-17 years old
* subject with no systemic diseas.

Exclusion Criteria:

* medically compressed patient
* patient with systemic disease

Primary outcomes:
measure: taste perception
timeFrame: taste perception for 90 subject of different body mass index
measure: oral health status
timeFrame: oral health status will be measured for 90 subject of different body mass index.
Secondary outcomes:
measure: salivary ghrelin hormone
timeFrame: Baseline :salivary collection for ghrelin , salivary leptin and salivary resistin in AL least two hours fasting for different body mass index subject
measure: salivary leptin hormone
timeFrame: Baseline :salivary collection for ghrelin , salivary leptin and salivary resistin in AL least two hours fasting for different body mass index subject
measure: salivary resistin hormone
timeFrame: Baseline :salivary collection for ghrelin , salivary leptin and salivary resistin in AL least two hours fasting for different body mass index subject
Other outcomes:
Locations:
Study officials:
References:
Clinical trial NCT01267617: Measuring Cardiovascular Stress in Patients on Hemodialysis
Official title: Measuring Cardiovascular Stress in Patients on Hemodialysis
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Hemodialysis
Hypotension
Circulatory Stress
Photo-plethysmography
Keywords: hemodialysis
hypotension
circulatory stress
photo-plethysmography
Lead sponsor: West Penn Allegheny Health System
Sponsor class: OTHER
First posted: 2010-12-28
Enrollment: 26
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: CASE_ONLY
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Outpatients receiving hemodialysis at a single center

Brief summary: To determine if proprietary software that uses pulse-wave analysis to interpret the output of a conventional pulse-oximeter, can predict the onset of circulatory stress, before changes in blood pressure and pulse occur, in patients undergoing outpatient hemodialysis.


Eligibility criteria: Inclusion Criteria:

* Patients having regular outpatient dialysis treatments
* Patients who are willing and able to provide informed consent

Exclusion Criteria:

* Patients who do not wish to participate
* Patients with contraindications to attachment of monitoring devices
* Patients with skin rash or hypersensitivity to the adhesive sensors

Primary outcomes:
measure: photoplethysmography
timeFrame: 5 hours
Secondary outcomes:
measure: blood pressure
timeFrame: 5 hours
Other outcomes:
Locations:
city: Pittsburgh
country: United States
facility: Allegheny General Hospital
state: Pennsylvania
Study officials:
affiliation: West Penn Allegheny Health System
name: Rita L McGill, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT03755817: Efficacy Assessment of SCENAR Device on Common Spinal Pain Syndrome
Official title: Immediate Efficacy Assessment of SCENAR's Session on a Common Spinal Pain Syndrome
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Pain Syndrome
Keywords: Spinal pain
Lead sponsor: Hopital Foch
Sponsor class: OTHER
First posted: 2018-11-28
Enrollment: 60
Sex: ALL
Minimum age (years): 18
Maximum age (years): 80
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: Randomized, singled blinded, controlled trial of the efficacy of a SCENAR session in patients with vertebral pain. SCENAR is an electrotherapy device.


Eligibility criteria: Inclusion Criteria:

* Male or female over 18 and under 80 years of age
* Suffering of common spinal pain: cervical pain including cervico-brachial neuralgia, lumbar pain including lumbo-radiculalgia
* Having attended a "pain consultation" or referred to a pain consultant during hospitalization
* Having signed the consent form
* Can be contacted directly by phone if patient is not hospitalized
* Be affiliated to a national insurance scheme or benefiting from such a program

Non-inclusion Criteria:

* Pregnant or breast-feeding women
* Patients with a pacemaker
* Patients whose skin condition makes the use of SCENAR impossible (wounds, recent scars, skin infections)
* Patient whose spinal pain is known to be related to inflammatory pathology (spondylarthropathy, rheumatoid arthritis, chondrocalcinosis), trauma (fractures and dislocations), tumor (metastases, myeloma localization), spondylodiscitis infectious, neurological (intrarachidian tumor or posterior fossa) or radiculalgia with deficient signs
* Patients who have already had a SCENAR session
* Patients who have already participated in this study

Primary outcomes:
measure: Efficacy on resting pain at the end of SCENAR application: NRS
timeFrame: 30 minutes
Secondary outcomes:
measure: Efficacy on pain at mobilization the end of SCENAR application: NRS
timeFrame: 30 minutes
measure: Efficacy on anxiety the end of SCENAR application: NRS
timeFrame: 30 minutes
measure: Efficacy on the sensation of spinal blockage at the end of SCENAR application: NRS
timeFrame: 30 minutes
measure: Efficacy on resting pain on the following day: NRS
timeFrame: 1 day
measure: Efficacy on pain at mobilization on the following day: NRS
timeFrame: 1 day
measure: Efficacy on the sensation of spinal blockage on the following day: NRS
timeFrame: 1 day
measure: Efficacy on anxiety on the following day: NRS
timeFrame: 1 day
measure: Collection of possible side effects
timeFrame: 1 day
Other outcomes:
Locations:
city: Suresnes
country: France
facility: Hôpital Foch
Study officials:
affiliation: Hopital Foch
name: Marc Fischler, MD PhD
role: STUDY_DIRECTOR
References:
Clinical trial NCT00072917: The Effects of Overfeeding on Obesity-Prone (OP) and Obesity-Resistant (OR) Women
Official title: The Effects of Overfeeding on Obesity-Prone (OP) and Obesity-Resistant (OR) Women
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Obesity
Thinness
Weight Gain
Keywords: obesity
thinness
weight gain
physical activity
diet
fat oxidation
hunger
feeding behavior
overfeeding
Lead sponsor: National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Sponsor class: NIH
First posted: 2003-11-14
Enrollment: 100
Sex: ALL
Minimum age (years): 25
Maximum age (years): 35
Standard ages: ADULT
Accepts healthy volunteers: yes
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Subjects have been recruited through advertisements in local news media and on the internet

Brief summary: This is a longitudinal cohort study of how the responses to a 3 day period of controlled overfeeding relate to subsequent weight gain. We hypothesize that thin individuals are resistant to weight gain because they respond to periods of overfeeding by increasing fat oxidation, reducing food intake, and increasing physical activity relative to those who gain weight over time.


Eligibility criteria: * Half of the subjects will be women, half will be men,
* age 25-35,
* a range of BMI's from 19-27, for the 'thin subjects' there should be no 1st degree relatives with a BMI\>30.
* Subjects should not engage in planned physical activity more than 3 hrs per week.
* For the obesity prone group there should be at least 1 1st degree relative with a BMI\>30.

Primary outcomes:
Secondary outcomes:
Other outcomes:
Locations:
city: Denver
country: United States
facility: University of Colorado Health Sciences Center
state: Colorado
Study officials:
References:
citation: Rynders CA, Pereira RI, Bergouignan A, Kealey EH, Bessesen DH. Associations Among Dietary Fat Oxidation Responses to Overfeeding and Weight Gain in Obesity-Prone and Resistant Adults. Obesity (Silver Spring). 2018 Nov;26(11):1758-1766. doi: 10.1002/oby.22321.
citation: Creasy SA, Rynders CA, Bergouignan A, Kealey EH, Bessesen DH. Free-Living Responses in Energy Balance to Short-Term Overfeeding in Adults Differing in Propensity for Obesity. Obesity (Silver Spring). 2018 Apr;26(4):696-702. doi: 10.1002/oby.22121.
Clinical trial NCT00461617: Double-Blind Comparison Between Mitiglinide and Nateglinide in Type 2 Diabetic Patients
Official title: Multicentre, Double-Dummy, Randomized, Double-Blind Comparison Between Mitiglinide and Nateglinide in the Patients With Type 2 Diabetes
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE3
Conditions: Diabetes
Keywords: diabetes
rapid and short acting insulin secretagogue
α-glucosidase inhibitor
HbA1C
insulin
Lead sponsor: Kissei Pharmaceutical Co., Ltd.
Sponsor class: INDUSTRY
First posted: 2007-04-18
Enrollment: 291
Sex: ALL
Minimum age (years): 25
Maximum age (years): 70
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The purpose of this study is to evaluate the efficacy and safety of Mitiglinide compared to Nateglinide for the treatment of type 2 diabetes.


Eligibility criteria: Inclusion Criteria:

* Type 2 diabetes patients with inadequate control of blood glucose with diet and/or exercise therapy

Exclusion Criteria:

* Type 1 diabetes patients
* Patients who require treatment with insulin
* Patients with severe diabetic complications (neuropathy, retinopathy or nephropathy)
* Patients with severe ketosis, diabetic coma or precoma
* Patients complicated with severe hepatic diseases
* Patients complicated with severe renal diseases
* Patients complicated with severe hypertension
* Patients complicated with severe cardiac disease
* Pregnant women or women possible to be pregnant, nursing women, or women who want to become pregnant during the study period

Primary outcomes:
measure: Hemoglobin A1C (HbA1C)
timeFrame: -2, 0, 4, 8, 10, 12, 16, 20 week
Secondary outcomes:
measure: Fasting plasma glucose level (FPG)
timeFrame: 0, 4, 8, 12, 16, 20 week
measure: Two-hour postprandial glucose level (PPG2)
timeFrame: 0, 12, 20 week
measure: One-hour postprandial glucose level (PPG1)
timeFrame: 0, 12, 20 week
Other outcomes:
Locations:
Study officials:
affiliation: Endocrinology Dept. of Fudan University Zhongshan Hospital
name: Xin Gao, Professor
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT06803017: Music Intervention in Exercise and Sport on Problematic Smartphone Use, Psychopathological Symptoms Among College Students
Official title: The Effect of Music Intervention in Exercise and Sport on Problematic Smartphone Use, Psychopathological Symptoms, Self-Esteem, and Impulsivity Traits Among College Students in China
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Problematic Smartphone Use
Lead sponsor: Universiti Sains Malaysia
Sponsor class: OTHER
First posted: 2025-01-31
Enrollment: 120
Sex: ALL
Minimum age (years): 18
Maximum age (years): 25
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: This study is to examine the effect of music intervention in exercise and sport on problematic smartphone use, psychopathological symptoms, self-esteem, and impulsivity traits in smartphone users among Chinese college students. The aim is to compare the effects of the combination of exercise and sport with fast-tempo music, slow-tempo music, and no music.


Eligibility criteria: Inclusion Criteria:

* University students aged between 18 and 25 years old (male or female)
* No cognitive impairment and able to complete the questionnaire clearly

Exclusion Criteria:

* Students with recent injuries such as broken bones, congenital diseases such as heart disease, or other status conditions that prevent them from playing moderate-to-high-intensity sports
* Excluded students with mental diseases, physical disabilities, or those who were unable or unwilling to participate in the trial

Primary outcomes:
measure: Smartphone Impact Scale (SIS)
timeFrame: 14 weeks
measure: Ryerson Social Anxiety Scales (RSAS)
timeFrame: 14 weeks
measure: Impulsive Behavior Short Scale-8 (I-8)
timeFrame: 14 weeks
measure: Depression Anxiety Stress Scale 8-items (DASS-8)
timeFrame: 14 weeks
measure: Multidimensional Self-Esteem Scale-12(MSES-12)
timeFrame: 14 weeks
measure: The SCRAM (Sleep, Circadian Rhythms, and Mood) Questionnaire
timeFrame: 14 weeks
Secondary outcomes:
Other outcomes:
Locations:
city: Kota Bharu
country: Malaysia
facility: USM
state: Kelantan
Study officials:
References:
Clinical trial NCT05231317: Effect of the Sustainable Diet on Gut Microbiota and the Metabolome: a Randomised Crossover Study
Official title: Effect of the Sustainable Diet on Gut Microbiota and the Metabolome: a Randomised Crossover Study
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Microbiota
Nutrition, Healthy
Keywords: Plant-based diet
Western diet
Gut microbiota,
Trimethylamine N-oxide
Human intervention study.
Lead sponsor: University of Ulster
Sponsor class: OTHER
Collaborators: name: Fondazione Edmund Mach
First posted: 2022-02-09
Enrollment: 20
Sex: ALL
Minimum age (years): 18
Maximum age (years): 70
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: CROSSOVER
Intervention model description: Cross-over single-blinded
Primary purpose: PREVENTION

Brief summary: Unhealthy diets are closely linked to non-communicable diseases and constitute higher risk of morbidity and mortality than unsafe sex, alcohol, tobacco and drugs use combined. According to the World Health Organization (WHO), a healthy diet follows a plant-based pattern with low quantities of red meat and a low simple sugar intake. It would also reduce anthropological ecologic impact. We hypothesize that a plant-based diet will beneficially modify the gut microbiota and metabolome, influencing also Trimethylamine N-oxide (TMAO), a metabolite associated to CVD.

This study has a randomized single blind crossover design that compares a plant-based diet towards a control western diet. It is applied to volunteers aged 18-70 years, N=20. Each dietary intervention (plant-based and western) would last for 16 consecutive days separated by a minimum of 7 weeks washout period (intervention 1-washout-intervention 2). Samples of blood urine and faeces will be collected at day 1 and 14 of each intervention. On day 14 will be performed L-carnitine challenge with 1200mg of L-carnitine to test the levels of TMAO), in for the next 2 consecutive days (24h and 48h post treatment).


Eligibility criteria: Inclusion Criteria:

* Free-living, apparently healthy adults
* Bmi\>18
* Aged 18-70 years at recruitment
* Non-smokers

Exclusion criteria:

* Non-free-living adults
* Adults \<18 or \>70 years at recruitment
* BMI\<18
* Current smokers

Primary outcomes:
measure: Gut microbiota changes
timeFrame: Change over 14 days
measure: Quantification of Trimethylamine N-oxide
timeFrame: Day 16
Secondary outcomes:
measure: Bioactivity of faecal water
timeFrame: Change over 14 days
measure: Effects on inflammatory markers of both diets
timeFrame: Change over 14 days
measure: Ex vivo effects of faecal water on gut pathobionts
timeFrame: Day 14
measure: Quantification of phytochemicals
timeFrame: Change over 14 days
measure: Quantification of Short Chain Fatty Acids (SCFA)
timeFrame: Change over 14 days
Other outcomes:
Locations:
city: Coleraine
country: United Kingdom
facility: Human Intervention Studies Unit, Ulster University
state: Londonderry
Study officials:
References:
Clinical trial NCT02064517: Treatments of the Necrosed Immature Teeth (REV)
Official title: Randomized Comparative Test Multicentric, Forward-looking Single-blind, Between a Reference Technique and an Innovative Technic.
Study type: INTERVENTIONAL
Overall status: TERMINATED
Phase: PHASE2
Conditions: Clinical and Radiographic Success in 24 Months
Keywords: Necrosed Immature monoradicular Teeth , Revascularisation pulpar, MTA apical barrier, Clinical and radiographic success
Lead sponsor: University Hospital, Brest
Sponsor class: OTHER
First posted: 2014-02-17
Enrollment: 16
Sex: ALL
Minimum age (years): 6
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: Estimate if the technique of revascularisation pulpaire (with some hydroxide of calcium) allows to obtain a better forecast of preservation of the tooth without complication than the conventional technique with the creation of an apicale barrier in the MTA in 24 months.


Eligibility criteria: Inclusion Criteria:

* patients presenting one or monoradicular immature definitive several teeth ( open apex) with a pulpar necrosis,
* 6-year-old patients in 17 years the parents(relatives) of which agree to give a lit(enlightened) written consent or patients of more than 18 years old.

Exclusion Criteria:

* general order: any pathology or treatment(processing) dissuading a treatment(processing) endodontic (patients at risk of infectious endocarditis) or pulling(entailing) an immunosuppression (diabetes, HIV, immunosuppresseurs treatments(processings) post-transplant, long-term corticoids, chemotherapies), allergy known about the used, antecedent products of cervico-facial radiotherapy, presenting subject of the communications problems, the pregnancy and the feeding.
* local order: generalized periodontal disease or superior located(localized) periodontal pocket in 3mm, crack or fracture(split) radiculaire, radiculaire reduction of the necrosed immature tooth

Primary outcomes:
measure: Followed in 24 months
timeFrame: 24 months
Secondary outcomes:
measure: Clinical and radiographic success
timeFrame: 3-6 months
measure: Return of the pulpaire sensibility
timeFrame: 3-6 months
measure: Obtaining of a closure apicale and of an increase of length and thickness of radiculaires walls
timeFrame: 3-6 months
measure: Appearance of complications (dyschromie dental)
timeFrame: 3-6 months
Other outcomes:
Locations:
city: Brest
country: France
facility: CHRU de Brest - Pôle Organe des Sens
city: Nantes
country: France
facility: Hôtel Dieu
city: Rennes
country: France
facility: CHU de Rennes
Study officials:
References:
Clinical trial NCT01830517: Diurnal Variation in Hypertensive Stroke Patients
Official title: Comparison of the Effects of Amlodipine and Losartan on Blood Pressure and Diurnal Variation in Hypertensive Stroke Patients
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE4
Conditions: Hypertension
Stroke
Lead sponsor: Hanmi Pharmaceutical Company Limited
Sponsor class: INDUSTRY
First posted: 2013-04-12
Enrollment: 84
Sex: ALL
Minimum age (years): 35
Maximum age (years): 85
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: This study was conducted to evaluate and compare the effectiveness of Amodipin® (amlodipine camsylate) with that of Cozaar® (losartan potassium) in hypertensive patients with an acute ischemic stroke by measuring their 24-hour ambulatory BP (ABP).


Eligibility criteria: Inclusion Criteria:

1. aged 35 to 85 years
2. hypertensive patients who had an ischemic stroke

Exclusion Criteria:

1. patients aged below 35 years or above 86 years;
2. patients who had a hemorrhagic stroke;
3. patients whose systolic BP (SBP) was over 220 mmHg or whose diastolic BP (DBP) was above 120 mmHg during an acute phase, or whose SBP was over 180 mmHg or whose DBP was over 110 mmHg one week after their hospital visit;
4. patients with secondary hypertension related to renovascular, endocrinologic, or pregnant conditions
5. patients who went to bed in the middle of the day or very late at night; (6) patients who were using intravenous antico-agulants or thrombolytics;

(7) patients with a severe stroke (NIH stroke scale \> 20); (8) patients who could not give their consent to investigators; (9) patients with severely impaired liver function (AST or ALT ≥ 100); (10) patients with severely impaired renal function (serum creatinine ≥ 2.0 mg/dL); (11) patients with cancer; (12) patients who were pregnant or lactating; (13) patients with other grave diseases such as hypertensive encephalopathy, aortic dissection, acute myocardial infarction, or severe congestive heart failure; and (14) patients who were allergic to the test or control drugs

Primary outcomes:
measure: 24-hour ambulatory mean SBP
timeFrame: baseline and 8weeks
Secondary outcomes:
measure: 24H mean DBP, 24H mean SBP/DBP Variability,clinic SBP/DBP, awake, sleep, morning, evening, and prewake BPs, the morning surge, and the nocturnal dipping
timeFrame: baseline and 8weeks
Other outcomes:
Locations:
city: Boramae-ro 5-gil 20, Dongjak-gu
country: Korea, Republic of
facility: Boramae Medical Center
state: Seoul
Study officials:
affiliation: SMG-SNU Boramae Medical Center
name: Hyunwoo Nam, M.D., Ph.D.
role: PRINCIPAL_INVESTIGATOR
References:
citation: Kwon HM, Shin JW, Lim JS, Hong YH, Lee YS, Nam H. Comparison of the effects of amlodipine and losartan on blood pressure and diurnal variation in hypertensive stroke patients: a prospective, randomized, double-blind, comparative parallel study. Clin Ther. 2013 Dec;35(12):1975-82. doi: 10.1016/j.clinthera.2013.10.013. Epub 2013 Dec 2.