Clinical trial NCT01938300: Magnesium and Rotational Thromboelastometry (ROTEM) in Colorectal Cancer Surgery
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Colorectal Cancer
Lead sponsor: Seoul National University Bundang Hospital
Sponsor class: OTHER
First posted: 2013-09-10
Enrollment: 44
Sex: ALL
Minimum age (years): 20
Maximum age (years): 90
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: PREVENTION

Brief summary: Magnesium sulphate is given to the patients during the colorectal cancer surgery under the hypothesis that it would attenuate the postoperative hypercoagulability. The investigators intend to characterize the changes of coagulation in colorectal cancer patients by using the point-of-care device after the infusion of magnesium sulphate.


Eligibility criteria: Inclusion Criteria:

* The patients undergoing a laparoscopic colorectal cancer surgery

Exclusion Criteria:

* Renal disease
* Hepatic disease
* Neuromuscular disease
* Coagulation disorder
* Cardiopulmonary disease

Primary outcomes:
measure: Change of maximum clot firmness (MCF) of FIBTEM
timeFrame: 1 day before a operation, 1 hour after finishing a operation, and a postopearative 3 day
measure: Change of Clotting time (CT) of INTEM
timeFrame: 1 day before a operation, 1 hour after finishing a operation, and a postopearative 3 day
measure: Change of Clot firmness time (CFT) of INTEM
timeFrame: 1 day before a operation, 1 hour after finishing a operation, and a postopearative 3 day
measure: Change of Alpha angle of INTEM
timeFrame: 1 day before a operation, 1 hour after finishing a operation, and a postopearative 3 day
measure: Change of MCF of INTEM
timeFrame: 1 day before a operation, 1 hour after finishing a operation, and a postopearative 3 day
measure: Change of CT of EXTEM
timeFrame: 1 day before a operation, 1 hour after finishing a operation, and a postopearative 3 day
measure: Change of CFT of EXTEM
timeFrame: 1 day before a operation, 1 hour after finishing a operation, and a postopearative 3 day
measure: Change of Alpha angle of EXTEM
timeFrame: 1 day before a operation, 1 hour after finishing a operation, and a postopearative 3 day
measure: Change of MCF of EXTEM
timeFrame: 1 day before a operation, 1 hour after finishing a operation, and a postopearative 3 day
Secondary outcomes:
measure: Change of Hemoglobin
timeFrame: 1 day before a operation, 1 hour after finishing a operation, and a postopearative 3 day
measure: Change of Platelet count
timeFrame: 1 day before a operation, 1 hour after finishing a operation, and a postopearative 3 day
measure: Change of International normalized ratio of prothrombin time
timeFrame: 1 day before a operation, 1 hour after finishing a operation, and a postopearative 3 day
measure: Change of Activated partial thrombin time
timeFrame: 1 day before a operation, 1 hour after finishing a operation, and a postopearative 3 day
measure: Change of Fibrinogen
timeFrame: 1 day before a operation, 1 hour after finishing a operation, and a postopearative 3 day
Other outcomes:
Locations:
city: Seongnam
country: Korea, Republic of
facility: Seoul National University Bundang Hospital
state: Gyeonggi
Study officials:
References: