Clinical trial NCT02657824: Rapid and Easy Evaluation of Cardiac Systolic Function by Means of Mitral Valve Movements in the Emergency Department
Official title: Rapid and Easy Evaluation of Cardiac Systolic Function by Means of Mitral Valve Movements in the Emergency Department
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Heart; Disease, Mitral(Valve)
Keywords: Ejection fraction
mitral valve
e-point septal separation
Lead sponsor: Bozyaka Training and Research Hospital
Sponsor class: OTHER
First posted: 2016-01-18
Enrollment: 113
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: an acutely dyspneic patients with receiving echocardigraphy by the chief physicians in the emergency department

Brief summary: Left ventricular ejection fraction (LVEF) is a parameter that should be evaluated rapidly to the patients, admitted to the emergency department with shortness of breath. The investigators aimed to investigate correlation between LVEF and 4 different mitral valve movements which alternate to the classical LVEF assessing methods and evaluate these methods can be used or not in the emergency department.

Detailed description: A prospective observational study was conducted in an acutely dyspneic patients with receiving echocardiagraphy by the chief physicians. Measurements were performed before echocardiography lab by the physician who conducted the survey in the emergency department. In parasternal long axis view mitral valve E-Point Septal Separation (EPSS) M-Mod measurements and mitral valve anterior leaflet and septal distance (P-ALSS) B-Mod measurements and in apical four chamber view mitral valve anterior leaflet and septal distance (A-ALSS) B-Mod measurements and distance between mitral valve anterior and posterior leaflets (MVLS) B-Mod measurements were acquired as the minimum distance in diastole. LVEF of patients were measured by cardiologist. Correlation of the all values between LVEF and sensitivity, specificity, and likelihood probabilities were calculated.

Eligibility criteria: Inclusion Criteria:

* older than 18 years
* nontraumatic acute dyspneic patients

Exclusion Criteria:

* sigmoid septum
* septal hypertrophia
* mitral stenosis
* mitral valve prothesis
* aortic regurgitation
* regional wall motion defect

Primary outcomes:
measure: Dyspneic patients were evaluated for their left ventricular ejection fraction by new methods with using transthoracic echocardiography.
timeFrame: up to 2 hours after admitting to the emergency department
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
affiliation: ızmır bozyaka traınıng and research hospital
name: neslihan siliv
role: PRINCIPAL_INVESTIGATOR
References:
citation: Secko MA, Lazar JM, Salciccioli LA, Stone MB. Can junior emergency physicians use E-point septal separation to accurately estimate left ventricular function in acutely dyspneic patients? Acad Emerg Med. 2011 Nov;18(11):1223-6. doi: 10.1111/j.1553-2712.2011.01196.x. Epub 2011 Nov 1.
citation: Weekes AJ, Reddy A, Lewis MR, Norton HJ. E-point septal separation compared to fractional shortening measurements of systolic function in emergency department patients: prospective randomized study. J Ultrasound Med. 2012 Dec;31(12):1891-7. doi: 10.7863/jum.2012.31.12.1891.
citation: McKaigney CJ, Krantz MJ, La Rocque CL, Hurst ND, Buchanan MS, Kendall JL. E-point septal separation: a bedside tool for emergency physician assessment of left ventricular ejection fraction. Am J Emerg Med. 2014 Jun;32(6):493-7. doi: 10.1016/j.ajem.2014.01.045. Epub 2014 Feb 3.