Clinical trial NCT06452134: Evaluation the Effect of Coenzyme Q10 on Tissue Healing Process in Patients Undergoing Wisdom Tooth Extraction
Official title: Evaluation the Effect of Coenzyme Q10 on Tissue Healing Process in Patients Undergoing Wisdom Tooth Extraction in the City of Sanandaj-Iran in 1402: a Double-blinded Clinical Trial Study
Study type: INTERVENTIONAL
Overall status: NOT_YET_RECRUITING
Phase: PHASE4
Conditions: Molar, Third
Temporomandibular Joint Disorders
Dry Socket
Coenzyme Q10
Keywords: coenzyme Q10
Dry Socket
Temporomandibular Joint Disorders
Molar, Third
SF-36 health survey
Tissue healing
Tooth Extraction
GHQ-12
Lead sponsor: Kurdistan University of Medical Sciences
Sponsor class: OTHER
Collaborators: name: Kurdistan University of Medical Sciences
name: Hady Mohammadi, Director of oral and maxillofacial surgery department, school of dentistry, Kurdistan university of medical sciences
name: Yousef Moradi, Assistant professor, Department of epidemiology and biostatistics, Kurdistan university of medical sciences
name: Babak Ghadirzadeh, medical student, Kurdistan university of medical sciences
First posted: 2024-06-11
Enrollment: 70
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The goal of this clinical trial is to asses the effect of Coenzyme Q10 administration in patients from any gender group who are older than 18 years old undergoing wisdom tooth extraction. The main questions it aims to answer are:

does Coenzyme Q10 help with better tissue healing? does Coenzyme Q10 administration lower the prevalence of Dry socket after surgery? does Coenzyme Q10 prevent TMD (Temporomandibular disorders) while recovering from surgery? how does Coenzyme Q10 administration effect the answers to SF-36 health survey in patients? Researchers will compare Coenzyme Q10 to a placebo (a look-alike substance that contains no drug) to see if it has any effect on mentioned parameters.

Participants will:

* take coenzyme Q10 (100mg) daily for 30 days after surgery.
* will be examined and evaluated 1, 7, 14 and 30 days after completion of surgery.


Eligibility criteria: Inclusion Criteria:

* Patients older than 18 years old that require mandibular or maxillary molar, third tooth extraction as Oral and Maxillofacial surgeon's clinical diagnosis.

Exclusion Criteria:

* The patient's departure from Sanandaj
* The patient's disagreement with the study protocol
* The Patient's demise
* The patient's hospitalization for unrelated illnesses
* The patient's discontent with the care they received
* The patient's failure to show up for follow-up appointments
* The patient's sensitivity to Coenzyme Q10

Primary outcomes:
measure: Rate of Tissue healing
timeFrame: 1, 7, 14 and 30 days after surgery
Secondary outcomes:
measure: Incidence of Temporomandibular disorders
timeFrame: 1, 7, 14 and 30 days after surgery
measure: Occurrence of Dry socket
timeFrame: 1, 7, 14 and 30 days after surgery
measure: Answers to The Short Form Health Survey-36
timeFrame: 1, 7, 14 and 30 days after surgery
measure: Answers to The General Health Questionnaire-12
timeFrame: 1, 7, 14 and 30 days after surgery
Other outcomes:
Locations:
Study officials:
affiliation: Zahra Nejati, Department of oral and maxillofacial medicine, School of Dentistry, Kurdistan University of Medical Sciences, Sanandaj, Iran.
name: Zahra Nejati
role: STUDY_DIRECTOR
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