louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT01909375: American Joint Replacement Registry
Official title: American Joint Replacement Registry
Study type: OBSERVATIONAL
Overall status: RECRUITING
Conditions: ARTHROPLASTY, REPLACEMENT
Lead sponsor: American Joint Replacement Registry
Sponsor class: OTHER
First posted: 2013-07-26
Enrollment: 500000
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: OTHER
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: We expect to receive data on up to 90% of all total joint arthroplasties conducted in the United States annually.

Brief summary: The American Joint Replacement Registry is a not-for-profit 501(c)(3) organization for data collection and quality improvement initiatives for total hip and knee replacements. The AJRR is a collaborative effort supported by the American Academy of Orthopaedic Surgeons (AAOS), the American Association of Hip and Knee Surgeons (AAHKS), The Hip Society, The Knee Society, hospitals, health insurers, medical device manufacturers, and contributions from individual orthopaedic surgeons.


Eligibility criteria: Inclusion Criteria:

* Any individual in the US undergoing total joint arthroplasty

Exclusion Criteria:

* None

Primary outcomes:
measure: Health Related Quality of Life
timeFrame: 12 months
Secondary outcomes:
measure: Hip disability and Osteoarthritis Outcome Score - Joint Replacement (HOOS, JR)
timeFrame: 12 months
Other outcomes:
measure: Knee Injury and Osteoarthritis Outcome Score - Joint Replacement (KOOS, JR)
timeFrame: 12 months
Locations:
city: Rosemont
country: United States
facility: Nathan Glusenkamp
state: Illinois
Study officials:
affiliation: American Joint Replacement Registry
name: Nathan Glusenkamp
role: PRINCIPAL_INVESTIGATOR
affiliation: American Joint Replacement Registry
name: David G Lewallen, MD
role: STUDY_DIRECTOR
References:
Clinical trial NCT03555175: Value Eccentric and Proprioception Exercise Into the Injury Effect in Amateur Football
Official title: Value Eccentric and Proprioception Exercise Into the Injury Effect in Amateur Football
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Hamstring Injury
Lead sponsor: University of Alcala
Sponsor class: OTHER
First posted: 2018-06-13
Enrollment: 30
Sex: MALE
Minimum age (years): 18
Maximum age (years): 30
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: CROSSOVER
Primary purpose: PREVENTION

Brief summary: This study evaluates the injury in amateur football, adding different excercise into the habitual practice. There are three groups, one of them do eccentric excercise, another group doing proprioception exercise and the last group don´t do any exercise.

Detailed description: There are three group with 10 participants each one. The group one will do hamstring eccentric exercise 12 series per 6 repeats. The group two will do three proprioception exercise 2 series per exercise and leg. And third group won't have add some exercise to their normal training.

All participants will do the exercises during 12 weeks. Before this 12 weeks they will be valuation with different tests, and this tests will have to repeat after this 12 weeks and 3 weeks after finish the exercises.

Eligibility criteria: Inclusion Criteria:

* Training three times per week, add match day
* More than two years of experience
* Not be injured
* Not having been operated on the lower extremity

Exclusion Criteria:

-

Primary outcomes:
measure: Y-Test (star test)
timeFrame: Three time. Before intervention, at the end and three weeks post-intervention
measure: Vertical Jump test
timeFrame: Three times. Before intervention, at the end and three weeks post-intervention
Secondary outcomes:
measure: Weight
timeFrame: Before start
measure: Years
timeFrame: Before start
measure: Height
timeFrame: Before start
measure: Years playing football
timeFrame: Before start
measure: Position in the team
timeFrame: Before start
Other outcomes:
Locations:
city: Getafe
country: Spain
facility: Daniela Fernandez
state: Madrid
Study officials:
affiliation: UAH
name: Daniela Fernandez
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT06588075: A Full Digital VS Conventional Protocol in Management of Zygomatico-Maxillary Complex Fracture
Official title: Evaluation of the Accuracy of Zygomatico-Maxillary Complex Fracture Reduction and Fixation Using a Full Digital Workflow Versus Conventional Protocol: a Randomized Clinical Trial
Study type: INTERVENTIONAL
Overall status: ACTIVE_NOT_RECRUITING
Phase: NA
Conditions: Zygomatic Fractures
Keywords: Zygomatic fracture
computer guided surgery
patient specific implant
predictive holes surgical guide
Zygomatico-Maxillary complex fracture
Lead sponsor: Cairo University
Sponsor class: OTHER
First posted: 2024-09-19
Enrollment: 28
Sex: ALL
Minimum age (years): 18
Maximum age (years): 60
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: this study aims To evaluate The Accuracy of Zygomatico- Maxillary Complex (ZMC) Fracture reduction and fixation Using customized Patient-Specific implant and patient-specific predictive holes surgical guide Versus Conventional Technique of reduction and fixation.

Detailed description: The ZMC has multiple points of articulation with the craniofacial skeleton making accurate assessment of reduction at all articulations intraoperative in multiple planes very challenging and the interference of soft tissue edema and a narrowed visual field increases the possibility of intraoperative overcorrection or underestimation of pre-injured position of all fracture lines at the same time resulting in a suboptimal reduction. As a trial to maximize the benefits of digital planning carrying the plan into a real operating room using a patient-specific surgical guide to predrill screw holes and guide patient-specific implants during fixation according to the planning depend on CT scan.

Eligibility criteria: Inclusion Criteria:

* Zygomatic Fracture Types III, IV, V, VII, and VIII according to Rowe and Killey's classification.
* Age range (18-60 years).
* Patients are willing for the surgical procedure and follow-up, with informed consent

Exclusion Criteria:

* Zygomatic Fracture Type I, II according to Rowe and Killey's classification.
* Patients with contraindications for general anesthesia.
* Patient on radiotherapy.
* Patients suffer from bone disease.

Primary outcomes:
measure: Zygomatic reposition
timeFrame: immediate postoperative
Secondary outcomes:
measure: intraoperative time
timeFrame: during the operation
measure: paresthesia
timeFrame: pre operative, immediate postoperative and 6 months post operative
measure: patient satisfaction
timeFrame: 6 months postoperative
Other outcomes:
Locations:
city: Giza
country: Egypt
facility: Cairo university
Study officials:
affiliation: Assistant lecturer oral and maxillofacial surgery department Future university in Egypt
name: Dina Ayman Fayek, M.Sc
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT05360875: The Effect of Endometrial Scratching on Patients With Endometriosis
Official title: The Effect of Endometrial Scratching on Patients With Endometriosis Undergoing IVF Treatment
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Endometriosis
IVF
Keywords: Endometriosis
Endometrial scratching
Endometrial receptivity
IVF
Pregnancy rates
Lead sponsor: Peking Union Medical College Hospital
Sponsor class: OTHER
First posted: 2022-05-04
Enrollment: 80
Sex: FEMALE
Minimum age (years): 22
Maximum age (years): 40
Standard ages: ADULT
Accepts healthy volunteers: no
Allocation: NON_RANDOMIZED
Intervention model: SINGLE_GROUP
Primary purpose: TREATMENT

Brief summary: We aimed to investigate whether endometrial scratching could improve IVF outcomes by enhancing endometrial receptivity in patients with endometriosis.


Eligibility criteria: Inclusion Criteria:

1.Endometriosis that surgery or pathology confirmed; 2. normal ovarian reserve; 3. at least one implantation failure history

Exclusion Criteria:

1. hydrosalpinx; 2.ademomyosis; 3.endocrine or self-immune disease; 4.serious medical condition; 5.Contraindications of intrauterine operation

Primary outcomes:
measure: clinical pregnancy rate
timeFrame: 6-7 weeks of gestation
Secondary outcomes:
Other outcomes:
Locations:
city: Beijing
country: China
facility: Peking Union Medical College Hospital
state: Beijing
Study officials:
References:
Clinical trial NCT06406075: Non-invasive Measurement of Glucose with Advanced Spectroscopy Techniques and Machine Learning Models
Official title: A Pilot Study to Assess the Ability of Advanced Spectroscopy Techniques and Machine Learning Models to Non-invasively Measure Glucose Robustly and Accurately
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Healthy
Keywords: Continuous glucose monitoring
Noninvasive
Transcutaneous
Lead sponsor: Liom Health AG
Sponsor class: INDUSTRY
First posted: 2024-05-09
Enrollment: 43
Sex: ALL
Minimum age (years): 18
Maximum age (years): 75
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: OTHER

Brief summary: Primary aim of this pilot study is to provide evidence for a non-invasive, continuous, and transcutaneous measurement method to determine blood glucose levels robustly and accurately.

Detailed description: The study is divided into 3 sub-studies focusing on

* Interchangeability of Lab demo 1.0
* Evaluation of advanced spectroscopy methods and their miniaturisation potential
* Robustness of machine learning model to changes over time

Eligibility criteria: Inclusion Criteria:

* Provide signed and dated written informed consent by study participant prior to any mandatory study-specific procedures, sample collection, or analysis
* Apparently healthy Male or Female adult aged between 18 and 75
* Willingness to follow the study procedures

Exclusion Criteria:

* In Female subjects: pregnancy or breastfeeding period
* A diagnosis of diabetes mellitus (any type) with ongoing insulin therapy (basal or basal plus bolus) or sulfonylurea therapy
* Prior severe hypoglycemia event (stage 3 or above; e.g., seizure, loss of consciousness, emergency hospitalisation)
* Prior event of severe hyperglycemia resulting in diabetic ketoacidosis or hyperosmolar hyperglycemic state, or emergency hospitalisation
* Documented medical history of bleeding disorder
* Being under anticoagulant medication
* Insufficient knowledge of project languages (English/German)
* Known sensitivity to medical-grade adhesives or other skin-related complications, which might influence the outcome

Primary outcomes:
measure: Comparison of glucose changes measured over a time series of transcutaneous measurements with reference measurements
timeFrame: The data is collected during the study procedure (up to 3 hours)
Secondary outcomes:
Other outcomes:
Locations:
city: Pfäffikon
country: Switzerland
facility: Liom Health AG
state: Schwyz
Study officials:
affiliation: Liom Health AG
name: Fabien Rebeaud, PhD
role: STUDY_DIRECTOR
References:
Clinical trial NCT04951375: Clinical Results of Arthroscopic Repair for Massive Rotator Cuff Tears of 14 Cases
Official title: Clinical Results of Arthroscopic Repair for Massive Rotator Cuff Tears of 14 Cases
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Rotator Cuff Tears
Keywords: Shoulder joint
Arthroscopy
Massive rotator cuff tears
Lead sponsor: Peking University Third Hospital
Sponsor class: OTHER
First posted: 2021-07-06
Enrollment: 14
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: CASE_ONLY
Time perspective: RETROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: From October, 2015 to December, 2017, 14 cases of massive rotator cuff tears who were treated with arthroscopic repair by the same doctor were included.

Brief summary: This study retrospectively analyzed data of 14 cases of massive rotator cuff tears who were treated with arthroscopic repair by the same doctor from October 2015 to December 2017, aiming to explore the surgical methods and clinical effects of arthroscopic repair for massive rotator cuff tears.

Detailed description: The preoperative and intraoperative data and patient information of 14 cases of arthroscopic repair of huge rotator cuff tears performed by Deputy Chief Physician Yang Yuping of the Institute of Sports Medicine of Peking University Third Hospital from January 2016 to August 2017 sort out. Collect and organize follow-up data on the recovery and motor function of patients 6 months after surgery and the latest follow-up (February 4 to March 3, 2018). Discuss the operation method, and statistically analyze the short-term curative effect of patients undergoing the operation.

Eligibility criteria: Inclusion Criteria:

* Diagnosed as massive rotator cuff tears and treated with arthroscopic repair from October, 2015 to December, 2017

Exclusion Criteria:

* None

Primary outcomes:
measure: VAS
timeFrame: 6 months after surgery
measure: DASH
timeFrame: 6 months after surgery
measure: OSS
timeFrame: 6 months after surgery
Secondary outcomes:
Other outcomes:
Locations:
city: Beijing
country: China
facility: Peking Univerisity Third Hospital
state: Beijing
Study officials:
affiliation: Peking University Third Hospital
name: Yuping Yang
role: STUDY_DIRECTOR
References:
Clinical trial NCT04474275: The Effect of the Mode of Delivery to the Pelvic Floor Function
Official title: The Effect of the Mode of Delivery to the Pelvic Floor Function
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Incontinence
Pelvic Organ Prolapse
Keywords: pelvic organ prolapse
Lead sponsor: Giresun University
Sponsor class: OTHER
First posted: 2020-07-16
Enrollment: 200
Sex: FEMALE
Minimum age (years): 18
Maximum age (years): 40
Standard ages: ADULT
Accepts healthy volunteers: yes
Observational model: CASE_CONTROL
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: 18-40 years old primiparous women who gave birth 5-10 years ago.

Brief summary: The childbirth is one of the risk factors for pelvic organ prolapse. In order to prevent the pelvic organ prolapse, the physicians do not routinely advice any exercises after deliveries. The investigators wondered if the mode of deliveries such as ceserean section, vaginal route delivery with episiotomy or vaginal route delivery without episiotomy effect the pelvic floor function differently or not. In order to evaluate this, the investigators are planning to measure the muscle tonus in primiparous women.


Eligibility criteria: Inclusion Criteria:

* Primiparous women 5-10 years after birth

Exclusion Criteria:

* Multiparous women Women with connective tissue disorders

Primary outcomes:
measure: Pelvic floor muscle tonus
timeFrame: 25.05.2020- 25.08.2020
Secondary outcomes:
measure: Female sexual function
timeFrame: 25.05.2020- 25.08.2020
Other outcomes:
Locations:
city: Giresun
country: Turkey
facility: Sebnem Alanya Tosun
Study officials:
References:
Clinical trial NCT02103075: Neuromuscular Electrical Stimulation on Median Nerve Facilitates Low Motor Cortex Excitability in Human With Spinocerebellar Ataxia
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Spinocerebellar Ataxia
Keywords: spinocerebellar ataxia (SCA)
motor evoked potential (MEP)
Neuromuscular electrical stimulation (NMES)
silent period
cerebellum
Lead sponsor: Chang Gung University
Sponsor class: OTHER
First posted: 2014-04-03
Enrollment: 29
Sex: ALL
Minimum age (years): 20
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: Spinocerebellar ataxia (SCA) is a hereditary disorder with movement incoordination. The ataxia performed low intra-cortical facilitation mainly due to the degenerative cerebellum. Noninvasive sensory stimulations such as peripheral electrical stimulation were reported to modulate the excitability of the motor excitability. Neuromuscular electrical stimulation (NMES) was proposed as a neuromodulation tool for the aberrant motor excitability on the SCA. This study aims to investigate the effect of NMES on the motor excitability in the SCA, and the differentiation on the central or peripheral motor excitability changed by the NMES.


Eligibility criteria: Inclusion Criteria:

* Clinical diagnosis of Spinocerebellar ataxia
* No history of epilepsy
* No other neuromuscular disorder
* No fracture within the last six months and restricted movement on the upper extremity
* Limited trembling hand allowed for the EMG recording.

Primary outcomes:
measure: Central Motor Excitability
timeFrame: Baseline, in experiment, 0 minute, 10 minutes, and 20 minutes.
measure: Peripheral Motor Excitability
timeFrame: Baseline, in experiment, 0 minute, 10 minutes, and 20 minutes.
Secondary outcomes:
Other outcomes:
Locations:
city: Taoyuan
country: Taiwan
facility: Chang Gung University
Study officials:
References:
citation: Chen CC, Chuang YF, Yang HC, Hsu MJ, Huang YZ, Chang YJ. Neuromuscular electrical stimulation of the median nerve facilitates low motor cortex excitability in patients with spinocerebellar ataxia. J Electromyogr Kinesiol. 2015 Feb;25(1):143-50. doi: 10.1016/j.jelekin.2014.10.009. Epub 2014 Nov 1.
Clinical trial NCT06881875: AI-Guided Stress Management Breathing Practices Via a Wearable Device
Official title: AI-Guided Stress Management Breathing Practices Using a Wearable Device: A Randomized Controlled Trial
Study type: INTERVENTIONAL
Overall status: NOT_YET_RECRUITING
Phase: NA
Conditions: Stress Reduction
Keywords: stress reduction
breathing practices
wearable device
AI guided intervention
Lead sponsor: Peking University
Sponsor class: OTHER
First posted: 2025-03-18
Enrollment: 120
Sex: ALL
Minimum age (years): 18
Maximum age (years): 30
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: This study explores the effectiveness of AI-guided breathing practices for stress management in adults. In this randomized controlled trial, 120 participants will be recruited and assigned to an intervention group (n=90) or a control group (n=30). The study includes four brief breathing practices, guided by a wristband. The intervention group will interact with an AI chatbot to receive a personalized daily breathing plan for 28 days, adjusted weekly based on feedback. Meanwhile, the control group will practice progressive muscle relaxation daily. It is hypothesized that, the intervention group will have significantly improvements in stress management and emotion regulation skills compare to the control group. These group differences are expected to persist at 1-month, 3-month and 6-month follow-up assessment.


Eligibility criteria: Inclusion Criteria:

1. Currently enrolled college students.
2. Aged between 18 and 30 years old.

Exclusion Criteria:

1. Current or past history of psychotic disorders.
2. Using contraceptives, cortisol, beta-blockers, antidepressants, or other psychiatric medications, as well as medications for chronic diseases during the intervention and follow-up periods.

Primary outcomes:
measure: Perceived stress
timeFrame: baseline, daily for 28 days, post-treatment(5 weeks), 10 weeks, 18 weeks, 30 weeks
measure: Emotion
timeFrame: baseline, daily for 28 days, post-treatment(5 weeks), 10 weeks, 18 weeks, 30 weeks
Secondary outcomes:
measure: Sleep quality
timeFrame: baseline, mid-treatment(2 weeks), post-treatment(5 weeks), 10 weeks, 18 weeks, 30 weeks
measure: Alexithymia
timeFrame: baseline, mid-treatment(2 weeks), post-treatment(5 weeks), 10 weeks, 18 weeks, 30 weeks
measure: Irritation
timeFrame: baseline, mid-treatment(2 weeks), post-treatment(5 weeks), 10 weeks, 18 weeks, 30 weeks
Other outcomes:
Locations:
city: Beijing
country: China
facility: Peking University
state: Beijing
Study officials:
References:
Clinical trial NCT02823275: Post Operative Quality of Life and Pain in Ankle Fractures: Cast Versus Functional Treatment
Official title: Post Operative Evaluation of Quality of Life and Pain in Ankle Fractures: Cast Immobilisation Versus Functional Treatment
Study type: INTERVENTIONAL
Overall status: TERMINATED
Phase: NA
Conditions: Ankle Fractures
Lead sponsor: Rijnstate Hospital
Sponsor class: OTHER
Collaborators: name: Radboud University Medical Center
First posted: 2016-07-06
Enrollment: 13
Sex: ALL
Minimum age (years): 18
Maximum age (years): 65
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: Rationale: Ankle fractures are common traumatic lesions. In order to restore the anatomical situation of the ankle joint to prevent posttraumatic arthritis, these fractures often need surgical treatment. Both cast immobilisation and functional treatment have proved to be reliable postoperative treatment regimes. Insight into the quality of life and the level of pain is necessary to determine if these treatments can be related to higher patient satisfaction and earlier resumption of daily activities and work.

Objective: The aim of this study is to examine two postoperative treatments for surgically corrected ankle fractures. Postoperative, direct functional mobilisation is compared to short term plaster cast fixation. The focus of this study is on quality of life, pain and the use of pain medication, and resumption of work and daily activities.

Main study parameters/endpoints:

Quality of life, Function, pain, swelling, daily activities and work, disabilities (pain disability index), complications


Eligibility criteria: Inclusion Criteria:

* Age 18-65 at the time of surgery
* Ankle fractures needing operative correction
* Weber type B or C, Lauge Hansen type supination-adduction, supination-external rotation and pronation-external rotation
* Closed fractures
* Postoperative stable for exercise
* Operated at the University Medical Centre St Radboud, Nijmegen or Alysis Zorggroep, Rijnstate Hospital, Arnhem

Exclusion Criteria:

* Open fractures
* Fractures with complete dislocation of the ankle joint
* Body Mass Index \> 30
* Previous ankle fracture on the affected side
* Concomitant traumatic injuries reducing the ability for postoperative mobilization
* Pre-existent use of pain medication, medication affecting fracture- and wound healing
* Postoperative unstable for exercise
* Co-morbidity: pain syndromes, Fontaine IIB, III and IV, symptomatic venous insufficiency, auto-immune disorders, rheumatic arthritis

Primary outcomes:
measure: pain
timeFrame: 6 weeks
measure: Pain medication used
timeFrame: 6 weeks
Secondary outcomes:
Other outcomes:
Locations:
city: Arnhem
country: Netherlands
facility: Rijnstate
state: Gelderland
city: Nijmegen
country: Netherlands
facility: Radboud University
state: Gelderland
Study officials:
References: