Clinical trial NCT04559659: Relationship Between Respiratory Muscle Strenght, Peripheral Muscle Blood Flow and Gait Speed in the Elderly
Official title: Study of the Relationship Between Respiratory Muscle Strenght, Peripheral Muscle Blood Flow and Gait Speed in the Elderly
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Age Problem
Keywords: blood flow velocity
aging
respiratory pressure
Lead sponsor: Hospital Israelita Albert Einstein
Sponsor class: OTHER
First posted: 2020-09-23
Enrollment: 50
Sex: ALL
Minimum age (years): 65
Maximum age (years): 100
Standard ages: OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: OTHER
Time perspective: CROSS_SECTIONAL
Sampling method: PROBABILITY_SAMPLE
Study population: Elderly of both sexes, over 65 years old, with and without inspiratory muscle weakness.

Brief summary: The pourpose of this study is to verify if have relationship between respiratory muscle strenght, peripheral muscle blood flow and gait speed in the elderly.

Detailed description: The hypothesis of this study is that elderly with inspiratory muscle weakness will present lower peripheral blood flow and consequently lower walking speed. The main aim of the study is to verify if the peripheral muscular blood flow in the elderly is different between patients with and without decrease in inspiratory muscle strength. As secondary objectives, it will be evaluated the correlation between inspiratory muscle strength and gait speed and quality of life, as well as gait speed and peripheral muscle blood flow. Fifty elderly patients of both sexes, over 65 years, from Vila Mariana Einstein Outpatient Clinic and Cora Residencial Senior, will be included to evaluate Maximum Inspiratory Pressure (Pimáx), Maximum Expiratory Pressure (Pemáx), Spirometry (FVC, PF, FEV1), 4.6m Walk Test, Quality of life for the elderly (WHOQOL old), Mini Mental Test, Body Mass Index (BMI) and peripheral muscle blood flow by venous occlusion plethysmography.

Eligibility criteria: Inclusion Criteria: Elderly of both sexes, over 65 years old

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Exclusion Criteria:

* Mini Mental Test \<24
* Morse ≥ 51
* Clinical instability, according to medical assessment • Structural heart disease, with ejection fraction \<50% and chronic lung diseases with FEV1 \<50% predicted,
* Neurological, orthopedic, or neuromuscular diseases that prevent the performance of evaluations
* Smokers or ex-smokers \<5 years

Primary outcomes:
measure: Peripheral muscle blood flow, gait speed and handgrip strength
timeFrame: Day 1
Secondary outcomes:
Other outcomes:
Locations:
city: São Paulo
country: Brazil
facility: RIAE Vila Mariana
Study officials:
affiliation: Hospital Israelita Albert Einstein
name: Luciana D Janot, doctor
role: PRINCIPAL_INVESTIGATOR
References:
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