Clinical trial NCT03450252: Pacemaker Therapy for Drug-refractory Symptoms in Mid-cavity Hypertrophic Cardiomyopathy
Official title: Distal Ventricular Pacing and Intraventricular Gradient Reduction for Symptomatic Relief in Drug Refractory Hypertrophic Cardiomyopathy Patients With Mid-cavity Obstruction
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Cardiomyopathy, Hypertrophic
Keywords: HCM
Mid-cavity
Pacing
Lead sponsor: Barts & The London NHS Trust
Sponsor class: OTHER
First posted: 2018-03-01
Enrollment: 17
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: CROSSOVER
Intervention model description: Taking part in this study will involve recording the information at a pre-implant visit, a visit for cardiac pacemaker implantation and follow-up visits four and eight months later.

At the pre-implant visit, participants will undergo assessment of symptoms, physical performance and blood test for a protein, Brain natriuretic peptide (BNP).

During the pacemaker implantation, the investigators will record the pressures within the heart using a catheter during both active pacing and back-up pacing settings.

The day after the pacemaker implant participants will undergo double-blind randomisation into either the treatment or non-treatment arm (active or back-up pacing respectively). At four months, cross-over takes place with assessment as above, before device reprogramming into either the treatment or non-treatment arm depending on which was completed first.

At the end of the second four month period, participants will undergo repeat assessment as above. That will conclude the study.
Primary purpose: TREATMENT

Brief summary: The main aim of this study is to assess the acute effects of a pacemaker on reducing abnormally high intracavity pressures in the hearts of patients with mid-cavity obstructive hypertrophic cardiomyopathy (HCM). During a 12-month period of double-blinded follow-up, descriptive data will be collected on patients symptomatic and physical performance during dichotomous pacemaker settings for 6-months each (active and back-up). The statistical information collected will be used to design a much larger research trial of patient benefit.

Detailed description: Hypertrophic cardiomyopathy (HCM) is the most common inherited heart disease, affecting 1 in 500 of the general population. It is characterised by abnormal thickening of the heart muscle. The various patterns of thickening of the muscle in the main pumping chamber, or left ventricle (LV), can result in obstruction to blood flow within the heart, raising the pressures in the heart and placing extra strain on the heart muscle.

The obstruction can cause patients to suffer from symptoms such as shortness of breath and chest pain, along with poor exercise tolerance, and dizzy spells. In very symptomatic patients with the commonest type of obstruction, invasive procedures performed either via an open-heart or keyhole operation can reduce the increased basal septal muscle mass at the point of obstruction. However, in around 1 in 10 HCM patients, the obstruction is deep within the LV where a ring of thick muscle blocks blood flow when it contracts. These patients provide a challenge for doctors, as this type of obstruction is much less suitable for open heart or keyhole operation.

An alternative is to use a cardiac pacemaker to alter the timing of the contraction in the ring of thick muscle such that different parts of the ring contract at different times and thereby reduce obstruction to blood flow. The investigators' early experience with this new treatment shows that carefully placing the pacemaker wires can reduce the obstruction and improve patient symptoms.

Key questions of this research include:

* How much can optimal ventricular pacing reduce the obstruction by?
* How important is choosing which part of the heart the pacemaker activates first?
* Does reducing obstruction in this way make patients better in the short and long term?

Eligibility criteria: Inclusion Criteria:

1. Male or female, \>18 years.
2. Referred for PPM +/- ICD implantation for either primary prevention of sudden cardiac death or other indications such as heart block or obstructive physiology.
3. HCM patients with evidence of mid-cavity gradient demonstrated by echocardiography and gradient ≥30 mmHg confirmed by cardiac catheterisation at rest or with isoprenaline provocation.
4. All patients should be taking maximum tolerated doses of beta blockers or verapamil with or without disopyramide.
5. Symptoms refractory to optimum medical therapy as above, for example breathlessness, chest pain, dizziness, or syncope.

Exclusion Criteria:

1. Patients with multi-level obstruction, i.e. across the mid-cavity and outflow tract.
2. Patients with moderate or severe valvular stenosis or regurgitation.
3. Patients with a history of myocardial infarction or acute coronary syndrome.
4. Patients unable to provide informed consent.
5. Patients in atrial fibrillation.
6. Pregnancy.
7. Renal failure.
8. If considered unsuitable by clinician.
9. Patients already participating in trials involving invasive procedures.

Primary outcomes:
measure: Invasive gradient (mmHg)
timeFrame: Measured during pacemaker implant. Pressure gradients will be measured at different pacing sites during the implant.
Secondary outcomes:
measure: Symptomatic assessment via SF36 questionnaire
timeFrame: Pre-implant, 4 months, and 8 months
measure: Symptomatic assessment via Kansas City Cardiomyopathy questionnaire
timeFrame: Pre-implant, 4 months, and 8 months
measure: Symptomatic assessment via calculation of New York Heart Association (NYHA) functional class
timeFrame: Pre-implant, 4 months, and 8 months
measure: Exercise performance assessed by 6 minute walk test (6MWT)
timeFrame: Pre-implant, 4 months, and 8 months
measure: Exercise performance assessed by Cardiopulmonary exercise testing (CPET) stress echocardiography.
timeFrame: Pre-implant, 4 months, and 8 months
measure: Levels of Brain Natriuretic Peptide
timeFrame: Pre-implant, 4 months, and 8 months
Other outcomes:
Locations:
city: London
country: United Kingdom
facility: Barts Heart Centre
state: Thames
Study officials:
affiliation: Barts Health NHS Trust and Queen Mary University of London
name: Saidi A Mohiddin, BSc, MBChB, FRCP, MD
role: PRINCIPAL_INVESTIGATOR
References: