louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT03353870: Requests for Euthanasia and Assisted Suicide in Establishment of Accommodation for Dependent Old Persons.
Official title: Requests for Euthanasia and Assisted Suicide in Establishment of Accommodation for Dependent Old Persons.
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Qualitative Research
Euthanasia
Assisted Suicide
Aging
Lead sponsor: Centre Hospitalier Universitaire de Besancon
Sponsor class: OTHER
First posted: 2017-11-27
Enrollment: 7
Sex: ALL
Minimum age (years): 65
Standard ages: OLDER_ADULT
Accepts healthy volunteers: no
Observational model: OTHER
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Person living in an establishment of accomation for dépendent old person and requesting an euthanasia.

Brief summary: The main aim of this project is to analyze and understand the meaning of explicit requests to hasten death (euthanasia and assisted suicide) from older people living in an Establishment of accommodation for dependent old persons.

This involves conducting interviews with patients, carers to whom the request has been expressed and a relative chosen by the patient. This study aims to describe the request over time. This will be done through two series of interviews, one as soon as it is first expressed, then one week later.


Eligibility criteria: Inclusion Criteria:

* They live in an establishment of accommodation for dependent old persons
* They have to be ill.
* They have request for euthanasie or assisted suicide
* They are in capacity to meet researchers for interview,
* They aggreed to make an individual interview
* They are covered by the French social security system

Exclusion Criteria:

* They have neurocognitives disorders that can't allow an individual interview
* They did not express themselves a request for euthanasia ou assisted suicide
* They disagreed to participate

Primary outcomes:
measure: Qualitative analyse
timeFrame: One year
Secondary outcomes:
Other outcomes:
Locations:
city: Besançon
country: France
facility: Clinical Investigation Center
state: Bourgogne-Franche-Comté
Study officials:
References:
Clinical trial NCT00707070: Combining Acitretin and Efalizumab in the Therapy of Chronic Plaque Psoriasis
Official title: Phase IV Study on Efficacy and Safety of the Combination Treatment Acitretin and Efalizumab in Moderate to Severe Chronic Plaque Psoriasis
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: PHASE4
Conditions: Chronic Plaque Psoriasis
Keywords: psoriasis
acitretin
efalizumab
Lead sponsor: Universita di Verona
Sponsor class: OTHER
First posted: 2008-06-30
Enrollment: 100
Sex: ALL
Minimum age (years): 18
Maximum age (years): 70
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: It is a phase IV multicentric, placebo-controlled, clinical trial investigating the efficacy and safety of acitretin combined to efalizumab in the therapy of chronic plaque psoriasis. PASI 75 at week 24 will be the primary end point. PASI 75 at week 12, and PASI 50 at week 24 will be the secondary end points. Safety measures will be the monitoring of serum parameters including AST; ALT; gammaGT; creatinine; cholesterol and triglycerides.


Eligibility criteria: Inclusion Criteria:

* Men aged 18-70
* Women in postmenopausal
* Moderate to severe chronic plaque psoriasis in patients with contraindication, intolerance or non responsive to cyclosporine, methotrexate or PUVA
* PASI \> 10 e/o BSA (Body Surface Area) \> 10

Exclusion Criteria:

* Drug induced psoriasis
* Pustular or erythrodermic psoriasis
* Fertile women
* Pregnancy or lactation
* cholesterol \> 230mg/dL e triglyceride \> 200 mg/dL
* Known intolerance to efalizumab and acitretin
* Serious infection at enrollement
* History of previous neoplasia

Primary outcomes:
measure: PASI 75 and PASI 50 at week 24 Physician Global Assessment
timeFrame: week 12 and 24
Secondary outcomes:
measure: SKINDEX 29 at week 24 and AST, ALT, cholesterol, triglycerides at week 12 and week 24
timeFrame: week 24
Other outcomes:
Locations:
city: Verona
country: Italy
facility: Univeristy Hospital
Study officials:
affiliation: Universita di Verona
name: Giampiero Girolomoni
role: PRINCIPAL_INVESTIGATOR
References:
citation: Gisondi P, Girolomoni G. Combination of efalizumab and acitretin in chronic plaque psoriasis. J Eur Acad Dermatol Venereol. 2008 Feb;22(2):247-8. doi: 10.1111/j.1468-3083.2007.02303.x. No abstract available.
Clinical trial NCT06459570: Efficacy of VR Based Sword Fighting Exercises to Improve Upper Body Movements in Hemiplegic Patients
Official title: Efficacy of VR Based Sword Fighting Exercises to Improve Upper Body Movements in Hemiplegic Patients
Study type: INTERVENTIONAL
Overall status: ACTIVE_NOT_RECRUITING
Phase: NA
Conditions: Hemiplegic Gait
Lead sponsor: Superior University
Sponsor class: OTHER
First posted: 2024-06-14
Enrollment: 62
Sex: ALL
Minimum age (years): 21
Maximum age (years): 80
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: HEALTH_SERVICES_RESEARCH

Brief summary: this thesis endeavors to shed light on the efficacy of VR-based sword-fighting exercises as a rehabilitation tool for improving upper body movement in hemiplegic patients.

Detailed description: By amalgamating clinical insights, technological advancements, and theoretical frameworks, this research aims to contribute to the growing body of knowledge in neurorehabilitation and pave the way for innovative, effective, and engaging interventions to enhance the lives of individuals affected by hemiplegia.

Eligibility criteria: Inclusion Criteria:

* Age 21-80 years
* First clinical stroke, ischemic or hemorrhagic, with diagnosis of stroke confirmed on CT/MRI brain scan.
* Less than 6 weeks after stroke onset
* Upper limb weakness of Medical Research Council (MRC) motor power of grade 2-4 motor power in either the shoulder, elbow or the fingers of the hemiplegic upper extremity
* Subject can understand simple instructions and learn

Exclusion Criteria:

* Recurrent stroke
* History of epilepsy
* Presence of arthritis or pain in the affected upper limb restricting repetitive exercises
* Severe aphasia or cognitive impairment, or other psychiatric illnesses that limit the ability to participate or give consent.

Primary outcomes:
measure: Fugl-Meyer Assessment of upper limb (FMA)
timeFrame: 12 Months
measure: Action Research Arm Test (ARAT)
timeFrame: 12 months
Secondary outcomes:
Other outcomes:
Locations:
city: Lahore
country: Pakistan
facility: Azra Naheed Medical College, Superior University
state: Punjab
Study officials:
References:
Clinical trial NCT03537170: Dietary Assessment and Prevalence of Refeeding Syndrome in High-risk TB Patients in Chhattisgarh, India
Official title: Dietary Assessment and Prevalence of Refeeding Syndrome in High-risk TB Patients in Chhattisgarh, India
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Tuberculosis
Refeeding Syndrome
Severe Malnutrition
Lead sponsor: Washington University School of Medicine
Sponsor class: OTHER
First posted: 2018-05-25
Enrollment: 31
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Severe tuberculosis patients admitted to the inpatient ward at Ganiyari hospital in Chhattisgarh, India.

Brief summary: Severe tuberculosis (TB) leads to wasting and anorexia, increasing risk of the refeeding syndrome (RFS) as defined by current criteria. TB patients have high metabolic rates and require a high calorie diet, with nutritional supplementation programs improving outcomes. BMI inversely correlates with mortality in these patients. Risk of RFS, a life-threatening syndrome associated with initiation of feeding after a period of low intake, has not been studied in this population and it is not known whether severely malnourished TB patients benefit from lower caloric intake. This study aimed to examine the prevalence of RFS in TB inpatients in rural India and correlate this with baseline and inpatient caloric intake.


Eligibility criteria: Inclusion Criteria:

* all adult inpatients admitted to the TB ward
* able to take enteral intake

Exclusion Criteria:

* unable to take enteral intake

Primary outcomes:
measure: Inpatient caloric intake
timeFrame: from date of admission to discharge, up to 100 weeks
Secondary outcomes:
measure: Incidence of refeeding syndrome
timeFrame: from date of admission to discharge, up to 100 weeks
Other outcomes:
Locations:
city: Ganiyari
country: India
facility: Jan Swasthya Sahyog
state: Chhattisgarh
Study officials:
References:
Clinical trial NCT04514770: Impact of Early Versus Late Amniotomy on Labour Induction in Nulliparous Women After Vaginal Misoprostol
Official title: Early Versus Late Amniotomy on Labour Induction in Nulliparous Women
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Labour Induction
Lead sponsor: Menoufia University
Sponsor class: OTHER
First posted: 2020-08-17
Enrollment: 140
Sex: FEMALE
Minimum age (years): 20
Maximum age (years): 40
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Intervention model description: Group A: Early amniotomy was performed for the participant of the first group at 3 cm cervical dilatation with Kocher's forceps provided the head is well fitted to the cervix. Group B: late amniotomy was performed for the participant of the second group at 7 cm cervical dilatation.
Primary purpose: TREATMENT

Brief summary: Investigation the effect of timing of amniotomy (early versus delayed) after vaginal misoprostol in induced labor.

Condition: induction of labour intervention: eary versus late amniotomy on labour induction after vaginal misoprostol Phase: Not applicable

Detailed description: study type: randomized clinical trial actual enrollment: 140 allocation: Random intervention model: two groups assignment masking: open lebal primary purpose: induction of labour actual study start: May 3, 2019 Primary Completion: January 10, 2020 actual study completion date: March 20, 2020

Eligibility criteria: Inclusion Criteria:

1. Pregnant women at 36 weeks gestation or more
2. Nullipara
3. singleton fetus
4. cephalic presentation with common medical causes for labour induction e.g. intrauterine fetal growth restriction, post term pregnancy and preeclampsia.

Exclusion Criteria:

1. Macrocosmic babies with estimated fetal weight of more than 4000 gram
2. Previous uterine scars
3. Pre labor premature rupture of fetal membranes
4. Polyhydramnios.

Primary outcomes:
measure: successful induction
timeFrame: immediately after intervention
measure: induction-delivery interval
timeFrame: immediately after intervention
Secondary outcomes:
measure: misoprostol doses administered
timeFrame: during the intervention
measure: the need for augmentation of labor
timeFrame: during the intervention
measure: intrapartum meconium
timeFrame: during the intervention
measure: Apgar score
timeFrame: during the intervention
measure: newborn admission in the neonatal intensive care unit
timeFrame: immediately after intervention
Other outcomes:
Locations:
city: Shibīn Al Kawm
country: Egypt
facility: Menoufia University hospital
state: Menoufia
Study officials:
References:
Clinical trial NCT05350670: Effect of Perineal Massage Combined With Cold Compress in the Second Stage on the Delivery Outcome of Primipara
Official title: Effect of Perineal Massage Combined With Cold Compress in the Second Stage on the Delivery Outcome of Primipara
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Cold Compress
Keywords: the second labor
perineal laceration
perineal massage
Lead sponsor: Second Affiliated Hospital of Wenzhou Medical University
Sponsor class: OTHER
First posted: 2022-04-28
Enrollment: 200
Sex: FEMALE
Minimum age (years): 20
Maximum age (years): 35
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: Objective: The aim of this study was to investigate the effect of perineal massage and cold compress in second stage on the delivery outcome of primipara.

Method: This interventional study included a total of 200 primipara hoping for natural birth. Patients were randomly divided into two groups, one group used routine labor, one group used cold compress and perineal massage. Record the time of second stage of labor, degree of perineal laceration, etc.


Eligibility criteria: Inclusion Criteria:

* want give birth naturally
* have well developed perineum

Exclusion Criteria:

* Abnormal fetal position and head basin
* Severe obstetric complications

Primary outcomes:
measure: the time of second stage of labor
timeFrame: until the end of the second stage of labor
measure: Degree of perineal laceration
timeFrame: about 30 minutes after the pregnant woman gives birth
measure: Lateral perineal resection rate
timeFrame: until the end of the second stage of labor
measure: Hospitalization days
timeFrame: up to 2 weeks
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
References:
Clinical trial NCT03115970: Feasibility of Lactate Level Evaluation in Prehospital Care in Trauma
Official title: Feasibility of Lactate Level Evaluation in Prehospital Care in Trauma
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Trauma, Multiple
Lactate Blood Increase
Lead sponsor: Masaryk Hospital Usti nad Labem
Sponsor class: OTHER
First posted: 2017-04-14
Enrollment: 30
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: Patient having / suspected to have severe trauma

Brief summary: Capillary or venous lactate level evaluation in prehospital care could be simple and beneficial tool for optimising prehospital care in patients with severe trauma.

Detailed description: Evaluation of blood lactate level and its trend are important morbidity and mortality predictive factors. In prehospital care, lactate level is more sensitive marker and have better prognostic value in severe trauma than basic vital signs. Worse outcome is associated with levels between 2 - 4 mmol/l. Measurement of lactate level in venous or capillary blood is quick and simple method with minimal risks and with no special needs for medical staff training. In spite of good availability of this method in the Czech Republic the method feasibility has never been analysed in patients with severe trauma.

Eligibility criteria: Inclusion Criteria:

* patient having / suspected to have severe trauma treated by cooperating Emergency Medical System organization

Exclusion Criteria:

* possible alterations of plasma lactate level in the time of trauma (seizure, malignity, use of beta-2 agonists, severe liver and/or kidney failure, ketoacidosis, intoxication)

Primary outcomes:
measure: Feasibility of lactate level measurement
timeFrame: 1 day - the time the patient is treated by Emergency Medical System
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
affiliation: Masaryk Hospital in Usti nad Labem
name: Marcela Bilska, Dr.
role: PRINCIPAL_INVESTIGATOR
References:
citation: Kruse O, Grunnet N, Barfod C. Blood lactate as a predictor for in-hospital mortality in patients admitted acutely to hospital: a systematic review. Scand J Trauma Resusc Emerg Med. 2011 Dec 28;19:74. doi: 10.1186/1757-7241-19-74.
citation: Jansen TC, van Bommel J, Mulder PG, Rommes JH, Schieveld SJ, Bakker J. The prognostic value of blood lactate levels relative to that of vital signs in the pre-hospital setting: a pilot study. Crit Care. 2008;12(6):R160. doi: 10.1186/cc7159. Epub 2008 Dec 17.
citation: Pearse RM. Extending the role of lactate measurement into the prehospital environment. Crit Care. 2009;13(1):115. doi: 10.1186/cc7687. Epub 2009 Feb 10.
citation: Rossaint R, Bouillon B, Cerny V, Coats TJ, Duranteau J, Fernandez-Mondejar E, Filipescu D, Hunt BJ, Komadina R, Nardi G, Neugebauer EA, Ozier Y, Riddez L, Schultz A, Vincent JL, Spahn DR. The European guideline on management of major bleeding and coagulopathy following trauma: fourth edition. Crit Care. 2016 Apr 12;20:100. doi: 10.1186/s13054-016-1265-x.
Clinical trial NCT01892670: Storage Temperature and Quality of Leucoreduced Whole Blood
Official title: Storage Temperature and Quality of Leucoreduced Whole Blood
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Trauma
Austere Environment
Blood Bank
Buddy Transfusion
Keywords: Blood
Whole blood
Cold-storage
Filtration
Transfusion
Platelet-function
Lead sponsor: Haukeland University Hospital
Sponsor class: OTHER
Collaborators: name: Norwegian Armed Forces Medical Service
First posted: 2013-07-04
Enrollment: 87
Sex: ALL
Minimum age (years): 18
Maximum age (years): 70
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: NON_RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: In a combat situation the need for safe and high-quality blood products is increasing. WB (Whole Blood) is used in many trauma situations, but we wish to investigate whether there is an even better whole blood product.

The purpose of this study is to examine the quality of leucoreduced, cold-stored whole blood. We also wish to examine the effects of filtration of whole blood without a 1-2 hour holding-time (warm-filtration) and the effects of forced filtration. We also wish to explore the possibility of using cold-stored WB for production of RCC.

Analyses are performed with a main focus to investigate function and quality of red blood cells and platelets.


Eligibility criteria: Inclusion Criteria:

* Healthy volunteer
* Age between 18 and 70
* Negative pregnancy test (women in fertile age)
* Blood pressure range: (160-100)/(100-40)
* Pulse range: 40-100

Exclusion Criteria:

* Usage of platelet-influencing medication
* Mild flu or more severe illnesses
* Open wound
* Pregnancy or trying to get pregnant

Primary outcomes:
measure: Platelet function
timeFrame: After 10 days of cold-storage
Secondary outcomes:
measure: Leukocyte count
timeFrame: After leukocyte filtration
Other outcomes:
measure: Hemolysis
timeFrame: After 42 days of storage
Locations:
city: Bergen
country: Norway
facility: Haukeland University Hospital, Dept of Immunology and Transfusion Medicine
Study officials:
affiliation: Haukeland University Hospital and Norwegian Naval Special Operation Commando
name: Geir Strandenes, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT06839170: An Assistant Model for IRD Care Needs: A Randomized Control Trial
Official title: A Multi-stage Evaluation Foundation Model for Inherited Retinal Diseases Care Needs: A Randomized Control Trial
Study type: INTERVENTIONAL
Overall status: RECRUITING
Phase: NA
Conditions: Inherited Retinal Diseases
Lead sponsor: Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine
Sponsor class: OTHER
First posted: 2025-02-21
Enrollment: 240
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: OTHER

Brief summary: Conduct a multicenter randomized controlled study based on the comprehensive deep learning model for inherited retinal diseases (EyeFM-IRDs). Through our established comprehensive deep learning model for inherited retinal diseases (EyeFM-IRDs model), the following objectives can be achieved: complete the initial screening of IRD patients based on the EyeFM-IRDs model, improve the correct referral of IRD patients to the fundus specialty or genetic eye disease specialty clinic; through consultation and ophthalmic examination, achieve the goal that the EyeFM-IRDs assisted by fundus doctors can improve the diagnosis of IRD compared to fundus doctors alone, effectively screen out negative patients, and avoid unnecessary WES examinations; based on a panel of gene mutation types with treatment methods that we have previously constructed. The EyeFM-IRDs model predicts the specific mutation genes of IRD patients based on consultation and fundus examination. This will improve the standardized diagnosis and treatment of IRD diseases, and also provide clinical support and research guidance for future research on IRDs.


Eligibility criteria: Inclusion Criteria:

* Presenting with clinical features suggestive of IRD based on the initial assessment by the physician

Exclusion Criteria:

* Refusal to undergo WES genetic testing.
* Screening for a history of intraocular surgery in both eyes within the past 6 months;
* Subjects with severe systemic diseases, intellectual developmental disorders, psychiatric illnesses, etc.
* Patient data that the investigator deems necessary to exclude.

Primary outcomes:
measure: The diagnostic accuracy of IRDs
timeFrame: 1 month
Secondary outcomes:
Other outcomes:
Locations:
city: Shanghai
country: China
facility: Shanghai General Hospital, Shanghai Jiao Tong University
city: ShangHai
country: China
facility: Shanghai general hospital
Study officials:
affiliation: Shanhai General Hopsital
name: Xiaodong Sun, PhD
role: PRINCIPAL_INVESTIGATOR
References: