louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT06882616: the Change in Carotid Intima-media Thickness After Laparoscopic Sleeve Gastrectomy
Official title: The Effect of Laparoscopic Sleeve Gastrectomy on the Change in Carotid Intima-media Thickness in Patients With Obesity: Prospective Randomized Trial
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Weight Loss
Reduce the Risk of Cardiac Disease
Carotis Intima-media Thickness
Keywords: Carotis intima-media thickness
Laparoscopic sleeve gastrectomy
Lead sponsor: Umraniye Education and Research Hospital
Sponsor class: OTHER_GOV
First posted: 2025-03-18
Enrollment: 65
Sex: ALL
Minimum age (years): 18
Maximum age (years): 65
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Intervention model description: Prospective, observational
Primary purpose: SCREENING

Brief summary: The aim of this study was to compare carotid intima-media thicknesses in laparoscopic sleeve gastrectomy patients preoperatively and at the end of the first postoperative year.

Detailed description: Obesity is not only a disease in itself, but also predisposes to many other diseases. Cardiac diseases are one of the systems that obesity predisposes to. Obesity has been found to increase the risk of cardiac disease by increasing carotid intima-media thickness in patients with obesity. Surgery is known to be the most effective treatment for obesity and laparoscopic sleeve gastrectomy is the most common bariatric surgery procedure. Laparoscopic sleeve gastrectomy may reduce the risk of cardiac disease by reducing carotid intima-media thickness in patients with obesity through effective weight loss.

Eligibility criteria: Inclusion Criteria:

* 18-65 years old,
* BMI \> 35 kg/m2
* Laparoscopic sleeve gastrectomy will be performed
* patients with cardiac disease

Exclusion Criteria:

* patients without cardiac disease
* patients who performed other bariatric surgery procedures

Primary outcomes:
measure: carotid intima-media thickness
timeFrame: From enrollment to the end of the first year after laparoscopic sleeve gastrectomy
Secondary outcomes:
Other outcomes:
Locations:
city: Istanbul
country: Turkey
facility: Muhammed Taha Demirpolat
state: Umraniye
Study officials:
affiliation: University of Health Sciences Umraniye Training and Research Hospital
name: Muhammed Taha Demirpolat, Assoc. Prof.
role: STUDY_DIRECTOR
References:
Clinical trial NCT03270696: Simultaneous Injection of Propofol and Rocuronium in Inducing General Anesthesia
Official title: Efficacy of Neuromuscular Blockade Before Facemask Ventilation in Inducing General Anesthesia
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Anesthesia; Functional
Lead sponsor: Seoul National University Hospital
Sponsor class: OTHER
First posted: 2017-09-01
Enrollment: 114
Sex: ALL
Minimum age (years): 20
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: This study is conducted to evaluate the efficacy of simultaneous injection of propofol and rocuronium in inducing general anesthesia.


Eligibility criteria: Inclusion Criteria:

* patients undergoing elective surgery requiring endotracheal intubation
* ASA I, II, and III
* above 20 years

Exclusion Criteria:

* refuse to enroll
* patients with risk of aspirating gastric contents
* patients in whom NMBs are contraindicated
* patients with predictors of difficult mask ventilation

Primary outcomes:
measure: mean tidal volume
timeFrame: from starting facemask ventilation for 1 minute
Secondary outcomes:
Other outcomes:
Locations:
city: Seoul
country: Korea, Republic of
facility: Seoul National University Hospital
Study officials:
affiliation: Seoul National University Hospital
name: JH Seo
role: PRINCIPAL_INVESTIGATOR
References:
citation: Min SH, Im H, Kim BR, Yoon S, Bahk JH, Seo JH. Randomized Trial Comparing Early and Late Administration of Rocuronium Before and After Checking Mask Ventilation in Patients With Normal Airways. Anesth Analg. 2019 Aug;129(2):380-386. doi: 10.1213/ANE.0000000000004060.
Clinical trial NCT02342496: Probiotics Against Low Grade Inflammation and Increased Intestinal Permeability in the Elderly
Official title: Probiotics Against Low Grade Inflammation and Increased Intestinal Permeability in the Elderly.
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Low-grade Inflammation
Increased Intestinal Permeability
Lead sponsor: Probi AB
Sponsor class: INDUSTRY
Collaborators: name: Lund University
First posted: 2015-01-21
Enrollment: 66
Sex: ALL
Minimum age (years): 75
Maximum age (years): 90
Standard ages: OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The purpose of this study is to evaluate the ability of a blend of berries and probiotics in reducing low-grade inflammation and intestinal permeability in the elderly. The intervention period is one month. Blood and fecal samples will be collected for analysis at baseline and at the end of the intervention with the aim to analyse possible changes in different parameters at the two timepoints. The participants will also be asked to keep a study diary throughout the study period for the documentation of their intestinal health and as a means for checking compliance.


Eligibility criteria: Inclusion Criteria:

* Age \>75 years
* CRP 2-10 mg/L
* Ability to fill in a study diary by him/herself

Exclusion Criteria:

* Intake of antibiotic treatment in the last 4 weeks before inclusion into the study.
* Currently on corticosteroid treatment
* Presence of chronic inflammatory disease

Primary outcomes:
measure: Reduced intestinal permebility measured as decline in the levels of zonulin in blood samples
timeFrame: All blood markers analysed in the study will be measured at start, before the onset of intervention and 4 weeks later at the end of intervention.
Secondary outcomes:
Other outcomes:
Locations:
city: Malmö
country: Sweden
facility: Lund University
Study officials:
References:
Clinical trial NCT00839696: Total Xenoestrogen Body Burden in Relation to Mammographic Density, a Marker of Breast Cancer Rlisk
Official title: Total Xenoestrogen Body Burden in Relation to Mammographic Density, a Marker of Breast Cancer Risk
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Breast Cancer Risk
Keywords: Breast
Estrogens
Mammography
Lead sponsor: University of Wisconsin, Madison
Sponsor class: OTHER
Collaborators: name: United States Department of Defense
First posted: 2009-02-09
Enrollment: 270
Sex: FEMALE
Minimum age (years): 55
Maximum age (years): 70
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: Subjects recruited from screening mammography population

Brief summary: Mammographic density is sensitive to estorgen exposure and constitutes a strong intermediate maker of breast cancer risk. We hypothesize that women with higher serum xenoestrogen levels will have greater mammographic density.


Eligibility criteria: Inclusion Criteria:

* 55-70 years of age, Post menopausal

Exclusion Criteria:

* If they have ever used hormone replacment therapy or have ever used Tamoxifen or Raloxifene, Diag. with breast cancer have had breast implants or have had a mastectomy/

Primary outcomes:
measure: Characterize the distribution of total xenoestrogen burden and identify important source of xenoestrogen exposure among a clinic-based sample of postmenopausal women.
timeFrame: 1 year
Secondary outcomes:
measure: Evaluate the association of total xenoestorgen exposure with mammographic density.
timeFrame: 1 year
Other outcomes:
Locations:
city: Madison
country: United States
facility: University of Wisconsin Hospital
state: Wisconsin
Study officials:
affiliation: Associate Professor- Population Health Sciences, UW School of Medicine and Public Health
name: Amy Trentham Dietz, PhD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT06178796: Bone-Implant Contact Surface Influence on Dental Implant Stability
Official title: Bone-Implant Contact Surface Influence on Dental Implant Stability in Fresh Extraction and Healed Sites
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Missing Teeth
Keywords: Dental implant, primary stability, immediate placement
Lead sponsor: Marmara University
Sponsor class: OTHER
First posted: 2023-12-21
Enrollment: 30
Sex: ALL
Minimum age (years): 18
Maximum age (years): 65
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: This study aims to evaluate the changes in the stability and bone-implant contact surface of implants of the same macro-design placed with particle grafting in the fresh extraction socket, without grafting, and placed in healed implant sites.


Eligibility criteria: Inclusion Criteria:

* Having a non-repairable premolar or molar tooth, or an edentulous area where the corresponding teeth have been extracted at least six months ago,
* At least 18 years old,
* Maintaining good dental hygiene,
* Having a favorable occlusion,
* Having intact socket walls after extraction.

Exclusion Criteria:

* Any local or systemic disorders that had contraindications for dental implant insertion,
* Pregnant and lactating women.

Primary outcomes:
measure: Change in Implant Stability Quotient (ISQ) values
timeFrame: 12 weeks
measure: Change in bone-implant contact surface
timeFrame: 12 weeks
measure: Primary insertion torque value
timeFrame: 1 day At the implant placement
Secondary outcomes:
Other outcomes:
Locations:
city: Istanbul
country: Turkey
facility: Marmara University School of Dentistry
Study officials:
References:
Clinical trial NCT03388996: Pelvic Microbiomes of Benign and Malignant Ovarian Diseases
Official title: The Role of Pelvic Microbiomes During the Malignant Transformation of Benign Ovarian Diseases
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Microbiota
Ovarian Neoplasms
Ribosome Alteration
Lead sponsor: Peking Union Medical College Hospital
Sponsor class: OTHER
Collaborators: name: Academy Military Medical Science, China
First posted: 2018-01-03
Enrollment: 40
Sex: FEMALE
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: CASE_CONTROL
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Group of benign ovarian diseases: patients with definite benigh ovarian diseases or health conditions (eg infertlity)

Group of malignant ovarian diseases: patients with definite diagnosis of high grade serous carcinoma

Brief summary: This case-control study aims to compare the pelvic microbiomes of benign ovarian diseases and ovarian malignancies by 16s RNA techniques and culture. Discharges/flushing fluid from vagina, faces and fimbria end of fallopian tube are collected from age and menopausal status matched patient before and during procedures of laparoscopies. The discharges/flushing fluid would be sent for 16s RNA analysis and microculture respectively, and the results would get self-contrasted comparison and case-control comparison.


Eligibility criteria: Inclusion Criteria:

* Laparoscopy procedures
* Specific pathological diagnosis

Exclusion Criteria:

* Previous history of pelvic surgeries
* Evidences of pelvic inflammation diseases

Primary outcomes:
measure: Difference of species distribution of microorganism according to 16s RNA analysis
timeFrame: 2 years
measure: Difference of species distribution of microorganism according to microculture outcomes
timeFrame: 2 years
Secondary outcomes:
Other outcomes:
Locations:
city: Beijing
country: China
facility: Peking Union Medical College Hospital
state: Beijing
Study officials:
affiliation: Peking Union Medical College Hospital
name: Lei Li, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT03723096: Expanded Access for CC-4047
Official title: Expanded Access for CC-4047
Study type: EXPANDED_ACCESS
Overall status: NO_LONGER_AVAILABLE
Conditions: Multiple Myeloma
Keywords: Expanded Access
Compassionate Use
Lead sponsor: Celgene
Sponsor class: INDUSTRY
First posted: 2018-10-29
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT

Brief summary: This is an expanded access program (EAP) for eligible participants designed to provide access to CC-4047.


Eligibility criteria: Inclusion Criteria:

-

Exclusion Criteria:

-

Primary outcomes:
Secondary outcomes:
Other outcomes:
Locations:
city: Summit
country: United States
facility: Celgene
state: New Jersey
Study officials:
References:
Clinical trial NCT00681096: Causes of Low Back Pain in Nurses in Israeli Hospitals
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Low Back Pain
Keywords: Low back pain in nurses
Lead sponsor: Hillel Yaffe Medical Center
Sponsor class: OTHER_GOV
First posted: 2008-05-21
Enrollment: 350
Sex: ALL
Minimum age (years): 18
Maximum age (years): 70
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Nurses working in 4 Israeli hospitals

Brief summary: An examination of the various factors that cause lower back pain in nurses in four hospitals in Israel such as; socio-demographic, professional, posture while ambulating patients and job environment.


Eligibility criteria: Inclusion Criteria:

* Nurses working in orthopedics, surgical, intensive care and internal medicine units

Exclusion Criteria:

* All others

Primary outcomes:
Secondary outcomes:
Other outcomes:
Locations:
city: Hadera
country: Israel
facility: Hillel Yaffe Medical Center
Study officials:
References:
Clinical trial NCT03171896: Effect of the Involvement of a Medical Clown on the Labor Experience
Official title: Effect of the Involvement of a Medical Clown on the Labor Experience
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Affective Symptoms
Lead sponsor: The Baruch Padeh Medical Center, Poriya
Sponsor class: OTHER_GOV
First posted: 2017-05-31
Enrollment: 40
Sex: FEMALE
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: NON_RANDOMIZED
Intervention model: PARALLEL
Primary purpose: SUPPORTIVE_CARE

Brief summary: The experience of labor for a woman can be rewarding but can be traumatic. Medical clowning may alleviate the potential for trauma.

Detailed description: The investigators plan to administer questionnaires to women who will agree to host a clown during their labor and to compare the feedback to those from women who did not.

Eligibility criteria: Inclusion Criteria:

Singleton pregnancy, Older than 18 years, Younger than 40 years, uncomplicated pregnancy

Exclusion Criteria:

Pregnancy complicated by PET, premature contractions Muktiple pregnancy, Older than 40 years, Younger than 18 years

Primary outcomes:
measure: Mood and satisfaction after labor
timeFrame: the day after delivery
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
References:
Clinical trial NCT06137196: Risk Identification Factors for Pulmonary Function Impairment in AIDS Patients Recovered From Severe Pneumonia
Official title: Study on Risk Identification Factors for Lung Function Impairment in AIDS Patients Recovered From Severe Pneumonia
Study type: OBSERVATIONAL
Overall status: RECRUITING
Conditions: AIDS
Pneumonia
Keywords: AIDS
Severe pneumonia
Lung function
Predictive factors
Lead sponsor: Guangzhou 8th People's Hospital
Sponsor class: OTHER
First posted: 2023-11-18
Enrollment: 100
Sex: ALL
Minimum age (years): 18
Maximum age (years): 65
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: All study participants come from the HIV/HBV co-infection cohort at the Guangzhou Eighth People's Hospital.

Brief summary: Screening for risk factors related to lung function impairment in patients who have recovered from AIDS with severe pneumonia, to provide clinical evidence for early identification and intervention of lung function damage in this population.

Detailed description: This is a prospective, single-center, non-randomized, clinical observational cohort study. It involves monitoring lung function at discharge (baseline, 0w), and at the 4th, 8th, 12th, 24th, and 48th weeks in patients recovering from severe pneumonia with AIDS. Basic demographic data, HIV RNA quantification, routine blood tests, blood biochemistry, arterial blood gas results, oxygenation index, immune function (CD3+, CD4+, CD8+ T cell counts), and imaging studies are also collected. Multifactorial logistic regression analysis is used to screen for clinical predictors of lung function decline in patients recovering from severe pneumonia

Eligibility criteria: Inclusion Criteria:

1. Confirmed HIV infection;
2. Progression to the AIDS stage: CD4+ count \<200 cells/µL and/or occurrence of opportunistic infections associated with AIDS;
3. Age between 18 to 65 years;
4. Meet the diagnostic criteria for severe pneumonia, with reference to the 2021 treatment guidelines for community-acquired pneumonia developed by the American Thoracic Society (ATS) and the Infectious Diseases Society of America (IDSA).

Exclusion Criteria:

1. Concurrent central nervous system lesions, severe liver disease, or cirrhosis;
2. Concurrent AIDS-related or non-related tumors;
3. Women who are pregnant or breastfeeding;
4. Presence of serious underlying diseases such as heart, lung, liver, kidney, etc.;
5. Alcohol abuse or drug use;
6. The researcher believes that the overall condition of the subject affects the evaluation and completion of the trial

Primary outcomes:
measure: Obstructive Ventilatory Dysfunction
timeFrame: 12 weeks
Secondary outcomes:
measure: FEV1
timeFrame: 12 weeks
Other outcomes:
Locations:
city: Guangzhou
country: China
facility: Guangzhou Eighth People's Hospital, Guangzhou Medical University
state: Guangdong
Study officials:
References:
Clinical trial NCT03500796: Combined Amniotic Membrane and Platelet Rich Plasma Clot for Management of Central Corneal Perforation
Official title: Combined Amniotic Membrane and Platelet Rich Plasma Clot for Management of Central Corneal Perforation
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Corneal Perforation
Lead sponsor: Minia University
Sponsor class: OTHER
First posted: 2018-04-18
Enrollment: 10
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: TREATMENT

Brief summary: Use of amniotic membrane(AMT) and platelet rich plasma (PRP) clot for closure of central corneal perforation

Detailed description: Use of amniotic membrane and platelet rich plasma clot for closure of central corneal perforation either post infective or posttraumatic

Eligibility criteria: Inclusion Criteria:

* central corneal perforation

Exclusion Criteria:

* active infection
* posterior segment pathology
* non seeing eye

Primary outcomes:
measure: Closure of the corneal wound
timeFrame: 3 months
Secondary outcomes:
Other outcomes:
Locations:
city: Minya
country: Egypt
facility: Faculty of Medicine
Study officials:
affiliation: Assistant professor of Ophthalmology, Faculty of Medicine
name: Ahmed A Abdelghany, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT02952196: Cannabioids as a New Intervention for Amphetamine Dependence
Official title: Cannabinoids as a New Intervention for Amphetamine Dependence: A Proof-of-concept Study
Study type: INTERVENTIONAL
Overall status: WITHDRAWN
Phase: PHASE2
Conditions: Amphetamine Addiction
Keywords: Amphetamine
Cannabinoids
Lead sponsor: Centre hospitalier de l'Université de Montréal (CHUM)
Sponsor class: OTHER
First posted: 2016-11-02
Enrollment: 0
Sex: ALL
Minimum age (years): 18
Maximum age (years): 65
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: PREVENTION

Brief summary: Addiction to amphetamine is characterized by alternating phases of intoxication and short abstinence, followed by recurrent drug-craving episodes which result in distress and relapse. Addiction involves a number of neurotransmission systems, including the endocannabinoid system (ECBS). It has been demonstarted that cannabidioids can have physiological, anxiolytic and neuroprotective properties. It has been shown to have multiple therapeutic properties for treating anxiety, schizophrenia and interestingly cannabinoids have been shown to be potentially helpful in treating addiction, due to their effects on various neuronal circuits involved in this disorder.

The investigators overall hypothesis is that cannabinoids are an interesting pharmacological contender to decrease amphetamine craving and treat amphetamine addiction.


Eligibility criteria: Inclusion Criteria:

* Current DSM-V criteria for amphetamine use disorder
* Ability to give valid, informed consent

Exclusion Criteria:

* Severe and/or unstable hepatic, neurologic (including diagnosis of seizures), cardiac (including arrhythmias) or renal disease, or any other severe or unstable medical condition that precludes safe participation in the study according to the study physician.
* Severe psychiatric condition (history of schizophrenia, schizoaffective disorder or bipolar disorder; current acute psychosis, mania or severe suicidality
* Any serious medical condition or psychiatric illness that precludes the subject from signing the informed consent form

Primary outcomes:
measure: assessing amphetamine craving
timeFrame: everyday during the study (that will last 3 days for each participants)
Secondary outcomes:
Other outcomes:
Locations:
city: Montreal
country: Canada
facility: Centre hospitalier de l'Université de Montréal
state: Quebec
Study officials:
affiliation: Centre hospitalier de l'Université de Montréal (CHUM)
name: Didier Jutras-Aswad, MD, MS
role: PRINCIPAL_INVESTIGATOR
References: