Clinical trial NCT01903915: Social Dysfunction and Brain Dysfunction in Patients With Schizophrenia
Official title: Resting-state Magnetic Resonance Imaging of Brain in Patients With Schizophrenia Compared With Healthy Controls to Prove the Association Between Social Cognition Dysfunction and Abnormality of Brain Function
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Schizophrenia
Social Cognition
Lead sponsor: Asan Medical Center
Sponsor class: OTHER
First posted: 2013-07-19
Enrollment: 100
Sex: ALL
Minimum age (years): 20
Maximum age (years): 40
Standard ages: ADULT
Accepts healthy volunteers: yes
Observational model: CASE_CONTROL
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: Patients groups will be selected from psychiatric clinic in general hospital - Asan Medical Center.

Brief summary: There were a few studies about the relationship of structural or functional abnormalities of brain and social cognitive dysfunctions in patients with schizophrenia. In addition, default network, which increases activity during mental explorations referenced to oneself including remembering, considering hypothetical social interactions, and thinking about one's own future, may be associated with social cognitive dysfunctions in patients with schizophrenia. Therefore, we will investigate the dysfunction of default network in patients with schizophrenia compared with healthy controls and the effect of default network dysfunctions on the social cognition in patients with schizophrenia.


Eligibility criteria: Patients group inclusion criteria:

* Right-handed
* Intelligent Quotient(IQ) above 80
* can read and understand the informed consent
* schizophrenia patients who was diagnosed from Structured Clinical Interview for Diagnostical and Statistical Manual of Mental Disorder 4th edition(DSM-IV, nonpatient version(SCID-NP) scales
* patient who has had reality distortion symptoms (like delusion or hallucination) in 5 years

Control group inclusion criteria :

* Right-handed
* IQ above 80
* do not have any diagnosis from SCID-NP scales
* do not have any family members who have psychiatric disorder

Exclusion criteria:

* have Illness which can affect brain structures and functions
* can't be taken magnetic resonance imaging(MRI)

Primary outcomes:
measure: Comparison of resting state functional MRI between schizophrenia patients and healthy controls
timeFrame: Baseline
Secondary outcomes:
Other outcomes:
Locations:
city: Seoul
country: Korea, Republic of
facility: Department of psychiatry, Asan Medical Center
Study officials:
affiliation: Department of Psychiatry, Asan Medical Center
name: Jung-Sun Lee, MD
role: PRINCIPAL_INVESTIGATOR
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