Clinical trial NCT03600259: Tianjin Inpatient Acute Myocardial Infarction Registry
Official title: Cohort Study of Acute Myocardial Infarction in Tianjin
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Myocardial Infarction, Acute
Keywords: Myocardial Infarction
Coronary Disease
Coronary Artery Disease
Myocardial Ischemia
Lead sponsor: Tianjin Chest Hospital
Sponsor class: OTHER
First posted: 2018-07-26
Enrollment: 13000
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: OTHER
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Hospitalized patients with acute myocardial infarction from 36 hospitals in Tianjin were enrolled between January 2015 and January 2020

Brief summary: Acute myocardial infarction(AMI) is the most serious manifestation of coronary artery disease. AMI is characterized by high mortality, high disability, and high cost. However, multicenter research on AMI with large sample size in Tianjin or even China is limited. By including AMI in 36 hospitals,this multicenter study will capture the changes in epidemiological trends ,analyze the status of treatment in Tianjin, and explore the best treatment strategies.


Eligibility criteria: Inclusion Criteria:

* Hospitalized patients with acute myocardial infarction according to Cardiac biomarker values \[Selective cardiac troponin (cTc) elevation and/or decline detection, at least one value exceeds the 99% reference limit (URL) and at least one of the following:（1）Symptoms of myocardial ischemia；（2）New or suspected new obvious ST-T changes or new left bundle branch block (LBBB)；（3）ECG pathological Q waves；（4）Image evidence of recent loss of viable myocardium, or new regional wall motion abnormalities；（5）Coronary thrombosis confirmed by angiography or autopsy.\]

Exclusion Criteria:

* Those who did not meet the diagnosis of acute myocardial infarction (no myocardial ischemia-related symptoms, elevation of markers of myocardial necrosis and imaging findings of myocardial infarction); those who met the inclusion criteria but refused to participate in the study; The researchers judged that the subjects had poor compliance and could not Complete follow-up as required.

Primary outcomes:
measure: Cardiac death
timeFrame: 1 year
Secondary outcomes:
measure: Major adverse cardiovascular events
timeFrame: 10 days on average (during hospitalization)
measure: Major adverse cardiovascular events
timeFrame: 1 month
measure: Major adverse cardiovascular events
timeFrame: 3 months
measure: Major adverse cardiovascular events
timeFrame: 6 months
measure: Major adverse cardiovascular events
timeFrame: 1 year
Other outcomes:
Locations:
city: Tianjin
country: China
facility: Tianjin Chest Hospital
state: Tianjin
Study officials:
affiliation: Tianjin Chest Hospital
name: Yin Liu, M.D
role: PRINCIPAL_INVESTIGATOR
References:
citation: Gao MD, Zhang EY, Liu YY, Li XW, Xiao JY, Sun GY, Liu Y. Intracoronary pressure gradient measurement in acute myocardial infarction patients with the no-reflow phenomenon during primary percutaneous coronary intervention. Chin Med J (Engl). 2020 Apr 5;133(7):766-772. doi: 10.1097/CM9.0000000000000709.