Clinical trial NCT00733941: Interval Training in Young Healthy Individuals
Official title: Interval Training: Training, Detraining and Retraining; an Interventional Study
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Healthy Subjects
Exercise Test
Keywords: Exercise test
Running
Arterial diameter
Monitoring, physiologic
Oxygen Consumption
Lead sponsor: Norwegian University of Science and Technology
Sponsor class: OTHER
First posted: 2008-08-13
Enrollment: 24
Sex: ALL
Minimum age (years): 18
Maximum age (years): 27
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: Individuals who participate in regular physical exercise possess a lower prevalence of cardiovascular risk factors such as hypertension, type 2 diabetes, obesity and hypercholesterolemia, and aerobic exercise is therefore considered an important adjuvant therapy in risk factor modification and to promote health.

The main focus of the present study is therefore to detect how rapid it is possible to increase aerobic capacity with interval running exercise.

The hypothesis is that it is possible to improve maximal oxygen uptake faster when increasing training frequency. The total gain in maximal oxygen uptake will however be the same between the two groups when they have performed the same amount of training

Detailed description: We will perform aerobic interval training at an intensity of 90-95% of maximum heart rate in healthy individuals. The subjects will be randomly assigned to carry out a total of 24 exercise-sessions, either at 3 times per week or 8 times per week.

The two groups will carry out 24 training sessions before 8 weeks of detraining will provide how rapidly aerobic capacity is lost due to inactivity. After the detraining period a retraining phase is introduced to detect if improvements in aerobic capacity occur more rapidly compared to before the first training period

The subjects will be tested for oxygen uptake, pumping capacity of the heart, blood volume, skeletal muscle enzyme activity, endothelial function.

Eligibility criteria: Inclusion Criteria:

* BMI\<27, non-smokers, train less that 1-2 times per week, VO2max \<60 for male and \<50 for female.

Exclusion Criteria:

* Hypertension, diabetes and cardiovascular disease.

Primary outcomes:
measure: Oxygen uptake
timeFrame: Before and after the training-, detraining- and retraining-phase
Secondary outcomes:
measure: Cardiac function and skeletal muscle enzyme activity
timeFrame: After training, detraining and retraining
Other outcomes:
Locations:
city: Trondheim
country: Norway
facility: Norwegian University of Science and Technology
city: Trondheim
country: Norway
facility: NTNU
Study officials:
affiliation: Norwegian University of Science and Technology
name: Øivind Rognmo, PhD
role: PRINCIPAL_INVESTIGATOR
affiliation: National Taiwan Normal University
name: Ulrik Wisløff, Professor
role: PRINCIPAL_INVESTIGATOR
References:
citation: Hatle H, Stobakk PK, Molmen HE, Bronstad E, Tjonna AE, Steinshamn S, Skogvoll E, Wisloff U, Ingul CB, Rognmo O. Effect of 24 sessions of high-intensity aerobic interval training carried out at either high or moderate frequency, a randomized trial. PLoS One. 2014 Feb 7;9(2):e88375. doi: 10.1371/journal.pone.0088375. eCollection 2014.