Clinical trial NCT05403619: Enhanced FoCUS in Patients With Shortness of Breath
Official title: Impact of an Enhanced Focused Cardiac Ultrasound on Treatment Modifications in a Population of Internal Medicine Patients: Retrospective Study
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Shortness of Breath
Acute Respiratory Failure
Keywords: Acute decompensated heart failure
Pneumonia
Pulmonary Embolism
Ultrasound
Lead sponsor: Nantes University Hospital
Sponsor class: OTHER
First posted: 2022-06-03
Enrollment: 119
Sex: ALL
Minimum age (years): 21
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: RETROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Patients hospitalized for acute shortness of breath

Brief summary: Retrospective observational study performed in a internal medicine ward of a French university hospital. Included patients were hospitalized for acute shortness of breath who have benefited from a eFOCUS which was defined as a focused cardiac Ultrasound with utilization of Doppler measurements.

The objectives were the therapeutic and diagnosis changes induced by eFoCUS. The primary endpoint was defined by the pooled introduction or discontinuation of diuretics, antibiotics or anticoagulants associated with eFoCUS results.

Detailed description: It was a retrospective observational study performed in a internal medicine ward of a French University Hospital. Patients were identified in the hospital database, pertinent features and eFoCUS findings were extracted and anonymized.

Inclusion criteria:

* Adult patients admitted to an internal medicine ward from the ED for acute shortness of breath.
* Realization of an eFoCUS prescribed by the physician in charge of the patient

Exclusion criteria:

• Comprehensive echocardiography already performed Methods For each identified patient, pertinent data (demography, initial diagnosis and treatment (diuretics, antibiotics, anticoagulants)) and eFoCUS findings were extracted from the hospital files, anonymized and entered in a LibreOffice spreadsheet. Extracted diagnosis were gathered into the following categories: Community-acquired pneumonia (CAP), Acute cardiogenic pulmonary edema (ACPE), Pulmonary embolism (PE), Chronic Obstructive Pulmonary Disease (COPD) and other (OTHER).

Objectives and endpoints

* The main objective was the therapeutic change induced by eFoCUS. The primary endpoint was defined by the pooled introduction or discontinuation of diuretics, antibiotics or anticoagulants associated with eFoCUS results.
* The secondary objectives were diagnosis modifications induced by eFoCUS. Data analysis
* Numerical data were presented as mean ± SD or as median with interquartile range depending on the normality. The paired Student's t-test was used to compare normally distributed data. The chi-square test was used for the comparison of noncontinuous variables expressed as proportions. A p-value \<0.05 was considered significant. All p-values were two-sided. Statistical analysis was realized with R (4.03.3) in the Rstudio® environment.

Eligibility criteria: Inclusion Criteria:

* Adult patients admitted to a internal medicine ward from the ED for acute shortness of breath.
* Realization of an eFoCUS prescribed by the physician in charge of the patient

Exclusion Criteria:

* Comprehensive echocardiography already performed

Primary outcomes:
measure: Pooled introduction or discontinuation of diuretics, antibiotics or anticoagulants
timeFrame: up to 24 hours after eFoCUS
Secondary outcomes:
measure: Changes of diagnostic categories associated with eFOCUS
timeFrame: up to 24 hours after eFoCUS
Other outcomes:
Locations:
city: Nantes
country: France
facility: Nantes University Hospital
Study officials:
References: