Clinical trial NCT06825286: Dexmedetomidine as an Adjuvant to Bupivacaine in Ultrasound-Guided Quadratus Lumborum Block for Postoperative Analgesia in Laparoscopic Cholecystectomy
Official title: The Effect of Dexmedetomidine as an Adjuvant to Bupivacaine in Ultrasound-Guided Quadratus Lumborum Block for Postoperative Analgesia in Laparoscopic Cholecystectomy: A Randomized Controlled Trial
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Dexmedetomidine
Bupivacaine
Ultrasound-Guided
Quadratus Lumborum Block
Postoperative Analgesia
Laparoscopic Cholecystectomy
Lead sponsor: Tanta University
Sponsor class: OTHER
First posted: 2025-02-13
Enrollment: 90
Sex: ALL
Minimum age (years): 21
Maximum age (years): 65
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The aim of this study is to evaluate the effect of adding Dexmedctomidinc as adjuvant to Bubivacaine in Ultrasound-Guided Quadratus Lumborum Block for Postoperative Analgesia in Laparoscopic Cholecystectomy.

Detailed description: When compared to conventional surgery, laparoscopic cholecystectomy is less invasive and leads to less postoperative pain. However, the postoperative pain following laparoscopic cholecystectomy consists of both somatic and visceral components with pain originating from port entry' wounds, gallbladder resection and abdominal insufflation that leads to peritoneal distention and peritoneal damage.

Quadratus lamborum block (QLB) is abdominal truncal block that provides both somatic and visceral analgesia for both upper and lower abdominal surgical procedures, It was first introduced by Blanco.Currently There are 4 approaches described for QLB: lateral, posterior, anterior and intramuscular. Transmuscular (anterior) QLB Type 3 block involves injection in the plane between the psoas major (PM) and the QL muscles studies have reported spread of the injectate to the thoracic paravertebral space, as well as the spinal nerve which runs anterior to the QL muscle

Eligibility criteria: Inclusion Criteria:

* Aged 21-65 years.
* Both genders.
* American society of Anesthesiology (ASA) class l, II undergoing elective laparoscopic cholecystectomy

Exclusion Criteria:

* Patient refusal
* History of allergy to local anesthetic.
* Liver or renal pathology affecting drug elimination
* Menta!dysfunction or cognitive disorders.
* Patients on chronic pain medications.
* Body Mass Index \> 40 kg/m2.
* Coagulopathy

Primary outcomes:
measure: Total morphine consumption
timeFrame: 24 hours postoperatively
Secondary outcomes:
measure: Mean arterial blood pressure
timeFrame: At the end of the operation(Up to 48 min).
measure: Heart rate
timeFrame: At the end of the operation (Up to 48 min).
measure: lntraoperative fentanyl consumption
timeFrame: lntraoperatively
measure: Degree of pain score
timeFrame: 24 hours postoperatively
measure: Time to the first request for the rescue analgesia
timeFrame: 24 hours postoperatively
measure: Incidence of Complication
timeFrame: 24 hours postoperatively
Other outcomes:
Locations:
city: Tanta
country: Egypt
facility: Tanta University
state: ElGharbia
Study officials:
References: