Clinical trial NCT06512948: Early Surgical Effects and Influencing Factors of High Tibial Osteotomy in the Treatment of Knee Osteoarthritis
Official title: Early Surgical Effects and Influencing Factors of High Tibial Osteotomy in the Treatment of Knee Osteoarthritis
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Osteoarthritis, Knee
Lead sponsor: Qianfoshan Hospital
Sponsor class: OTHER
First posted: 2024-07-22
Enrollment: 78
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: OTHER
Time perspective: RETROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: The study subjects were patients who underwent medial open HTO for KOA at the First Affiliated Hospital of Shandong First Medical University from January 2018 to December 2020. This article included a total of 45 patients with grade II and grade III according to the Kellgren-Lawrence arthritis classification. There were 28 cases, including 5 grade IV patients.

Brief summary: Exploring the factors influencing postoperative functional recovery after high tibial osteotomy

Detailed description: A retrospective study was conducted on patients who underwent HTO at the First Affiliated Hospital of Shandong First Medical University from January 2018 to December 2020, and the preoperative and postoperative imaging indicators \[medial proximal tibial angle (MPTA), joint line intersection angle (JLCA), hip-knee-ankle angle (HKA angle), knee weight-bearing line percentage (WBL%), postoperative distraction distance, postoperative distraction angle\] and knee joint function score \[including the American Hospital for Special Surgery (HSS) knee score, American Knee Society score (KSS), Lysholm score, Western Ontario and McMaster Universities Osteoarthritis Index score (WOMAC), and all were included in logistic regression analysis to study the surgical effect and impact of HTO factor

Eligibility criteria: Inclusion Criteria:

* Medial knee OA, varus deformity is mainly in the tibia
* Aged ≤70 years old, with higher requirements for future activities
* Knee joint extension is limited to ≤10°, and flexion is \>90°
* Body Mass Index (BMI) ≤ 40
* No subchondral bone wear

Exclusion Criteria:

* There is a history of fracture or surgery of the lower limb on the operated side
* Traumatic KOA
* Combined with nerve, muscle or connective tissue diseases
* Incomplete imaging data and loss of follow-up

Primary outcomes:
measure: Imaging parameters
timeFrame: an average of 1 year after the surgery
measure: Imaging parameters
timeFrame: an average of 1 year after the surgery
measure: Imaging parameters
timeFrame: an average of 1 year after the surgery
measure: Imaging parameters
timeFrame: an average of 1 year after the surgery
measure: Imaging parameters
timeFrame: an average of 1 year after the surgery
measure: Imaging parameters
timeFrame: an average of 1 year after the surgery
Secondary outcomes:
measure: function score
timeFrame: an average of 1 year after the surgery
measure: function score
timeFrame: an average of 1 year after the surgery
measure: function score
timeFrame: an average of 1 year after the surgery
measure: function score
timeFrame: an average of 1 year after the surgery
Other outcomes:
Locations:
city: Jinan
country: China
facility: The First Affiliated Hospital of Shandong First Medical University
state: Shandong
Study officials:
affiliation: Shandong First Medical University
name: Zhang Zhao, professor
role: STUDY_DIRECTOR
References: