Clinical trial NCT01732822: A Study Comparing Cardiovascular Effects of Ticagrelor and Clopidogrel in Patients With Peripheral Artery Disease
Official title: A Randomized, Double-blind, Parallel Group, Multicentre Phase IIIb Study to Compare Ticagrelor With Clopidogrel Treatment on the Risk of Cardiovascular Death, Myocardial Infarction and Ischemic Stroke in Patients With Established Peripheral Artery Disease (EUCLID Examining Use of tiCagreLor In paD)
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE3
Conditions: Peripheral Artery Disease
Keywords: Peripheral artery disease Atherothrombotic events Atherosclerosis
Lead sponsor: AstraZeneca
Sponsor class: INDUSTRY
First posted: 2012-11-26
Enrollment: 13885
Sex: ALL
Minimum age (years): 50
Maximum age (years): 130
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: PREVENTION

Brief summary: The purpose of this study is to compare the effects of ticagrelor and clopidogrel in patients with Peripheral Artery Disease.

Detailed description: A randomized, double-blind, parallel group, multicentre phase IIIb study to compare ticagrelor with clopidogrel treatment on the risk of cardiovascular death, myocardial infarction and ischemic stroke in patients with established Peripheral Artery Disease (EUCLID Examining Use of tiCagreLor In paD)

Eligibility criteria: Inclusion Criteria:

* Male and Female patients 50 years old or older Symptomatic peripheral artery disease

Exclusion Criteria:

* Patients needing dual anti-platlet drug treatment before start of study Planned revascularisation or amputation
* Patients with known bleeding disorders
* Patients with a history of intracranial bleed
* Patients considered to be at risk of bradycardic events unless already treated with a permanent pacemaker

Primary outcomes:
measure: Composite of Cardiovascular (CV) Death/MI/Ischemic Stroke
timeFrame: From randomization to PACD, an average of 2.5 years
Secondary outcomes:
measure: Composite of CV Death, MI, Ischemic Stroke, and ALI
timeFrame: From randomization to PACD, an average of 2.5 years
measure: CV Death
timeFrame: From randomization to PACD, an average of 2.5 years
measure: MI
timeFrame: From randomization to PACD, an average of 2.5 years
measure: All-cause Mortality
timeFrame: From randomization to PACD, an average of 2.5 years
measure: Composite of CV Death, MI, and All-cause Stroke (Ischemic or Hemorrhagic)
timeFrame: From randomization to PACD, an average of 2.5 years
measure: ALI
timeFrame: From randomization to PACD, an average of 2.5 years
measure: Lower Extremity Revascularization
timeFrame: From randomization to PACD, an average of 2.5 years
measure: Any Revascularisation (Coronary, Peripheral [Limb, Mesenteric, Renal, Carotid and Other])
timeFrame: From randomization to PACD, an average of 2.5 years
Other outcomes:
measure: Net Clinical Benefit (Composite of CV Death/MI/Ischemic Stroke/Fatal Bleeding/Intracranial Bleeding)
timeFrame: From randomization to PACD, an average of 2.5 years
measure: Net Clinical Benefit (Composite of All-cause Mortality/MI/Ischemic Stroke/Fatal Bleeding/Intracranial Bleeding)
timeFrame: From randomization to PACD, an average of 2.5 years
measure: Net Clinical Benefit (Composite of All-cause Mortality/MI/Ischemic Stroke/ALI/Major Amputation/Fatal Bleeding/Intracranial Bleeding)
timeFrame: From randomization to PACD, an average of 2.5 years
measure: Net Clinical Benefit (Composite of All-cause Mortality/MI/Ischemic Stroke/ALI/Major Amputation/TIMI Major Bleeding)
timeFrame: From randomization to PACD, an average of 2.5 years
measure: Non-CV Death
timeFrame: From randomization to PACD, an average of 2.5 years
measure: Changes in Fontaine Stage
timeFrame: From randomization to PACD, an average of 2.5 years
measure: Changes in Rutherford Classification
timeFrame: From randomization to PACD, an average of 2.5 years
measure: Change in ABI/TBI From Baseline
timeFrame: From randomization to PACD, an average of 2.5 years
measure: Any Amputation Caused by PAD
timeFrame: From randomization to PACD, an average of 2.5 years
measure: Major Amputation Caused by PAD
timeFrame: From randomization to PACD, an average of 2.5 years
measure: CV-related Hospitalization
timeFrame: From randomization to PACD, an average of 2.5 years
measure: TIMI Major Bleeding Events
timeFrame: From the date of first dose and up to and including 7 days following the date of last dose of study drug
measure: TIMI Major or Minor Bleeding Events
timeFrame: From the date of first dose and up to and including 7 days following the date of last dose of study drug
measure: PLATO Major Bleeding Events
timeFrame: From the date of first dose and up to and including 7 days following the date of last dose of study drug
measure: Premature Permanent Discontinuation of Study Drug Due to Any Bleeding Event
timeFrame: From the date of first dose and up to and including 7 days following the date of last dose of study drug
Locations:
city: Alexander City
country: United States
facility: Research Site
state: Alabama
city: Auburn
country: United States
facility: Research Site
state: Alabama
city: Birmingham
country: United States
facility: Research Site
state: Alabama
city: Birmingham
country: United States
facility: Research Site
state: Alabama
city: Mobile
country: United States
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state: Alabama
city: Mobile
country: United States
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state: Alabama
city: Mobile
country: United States
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state: Alabama
city: Cottonwood
country: United States
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state: Arizona
city: Mesa
country: United States
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state: Arizona
city: Phoenix
country: United States
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state: Arizona
city: Phoenix
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state: Arizona
city: Scottsdale
country: United States
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state: Arizona
city: Fort Smith
country: United States
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state: Arkansas
city: Jonesboro
country: United States
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state: Arkansas
city: Little Rock
country: United States
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state: Arkansas
city: Anaheim
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state: California
city: Berkeley
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city: Beverly Hills
country: United States
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city: Chula Vista
country: United States
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city: El Cajon
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city: Fresno
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city: La Jolla
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city: Laguna Hills
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city: Palo Alto
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city: Washington, D.C.
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city: Saint Petersburg
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city: Saint Petersburg
country: United States
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city: Sarasota
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city: Stuart
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city: Trinity
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city: Vero Beach
country: United States
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state: Florida
city: Wellington
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city: West Palm Beach
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city: Atlanta
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state: Georgia
city: Atlanta
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state: Georgia
city: Augusta
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state: Georgia
city: Cumming
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city: Lithonia
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city: Macon
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city: Arlington Heights
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city: Chicago
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city: Hinsdale
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city: Fort Wayne
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city: Fort Wayne
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city: Indianapolis
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state: Indiana
city: Indianapolis
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city: Merrillville
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state: Indiana
city: Muncie
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state: Indiana
city: Munster
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state: Indiana
city: Valparaiso
country: United States
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state: Indiana
city: Iowa City
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city: West Des Moines
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city: Edgewood
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state: Kentucky
city: Louisville
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state: Kentucky
city: Owensboro
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city: Baton Rouge
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city: Bossier City
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city: Shreveport
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state: Louisiana
city: Shreveport
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state: Louisiana
city: Auburn
country: United States
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state: Maine
city: Baltimore
country: United States
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state: Maryland
city: Beltsville
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state: Maryland
city: Columbia
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city: Greenbelt
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state: Maryland
city: Fall River
country: United States
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state: Massachusetts
city: Haverhill
country: United States
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state: Massachusetts
city: Worcester
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state: Massachusetts
city: Flint
country: United States
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state: Michigan
city: Flint
country: United States
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state: Michigan
city: Grand Rapids
country: United States
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city: Kalamazoo
country: United States
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state: Michigan
city: Lansing
country: United States
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city: Mount Clemens
country: United States
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city: Muskegon
country: United States
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city: Duluth
country: United States
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state: Minnesota
city: Minneapolis
country: United States
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state: Minnesota
city: Minneapolis
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city: Saint Cloud
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city: Biloxi
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state: Mississippi
city: Jackson
country: United States
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state: Mississippi
city: Tupelo
country: United States
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state: Mississippi
city: Kansas City
country: United States
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state: Missouri
city: Saint Louis
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state: Missouri
city: Saint Louis
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city: Saint Louis
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city: Kalispell
country: United States
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state: Montana
city: Lincoln
country: United States
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state: Nebraska
city: Lincoln
country: United States
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state: Nebraska
city: Las Vegas
country: United States
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state: Nevada
city: Las Vegas
country: United States
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state: Nevada
city: North Las Vegas
country: United States
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state: Nevada
city: Belleville
country: United States
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state: New Jersey
city: Bridgewater
country: United States
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state: New Jersey
city: Camden
country: United States
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state: New Jersey
city: East Orange
country: United States
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state: New Jersey
city: Eatontown
country: United States
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state: New Jersey
city: Elmer
country: United States
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state: New Jersey
city: Flemington
country: United States
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state: New Jersey
city: Freehold
country: United States
facility: Research Site
state: New Jersey
city: Hackensack
country: United States
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state: New Jersey
city: Haddon Heights
country: United States
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state: New Jersey
city: Linden
country: United States
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state: New Jersey
city: New Brunswick
country: United States
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state: New Jersey
city: Newark
country: United States
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state: New Jersey
city: Newark
country: United States
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state: New Jersey
city: Ocean City
country: United States
facility: Research Site
state: New Jersey
city: Sewell
country: United States
facility: Research Site
state: New Jersey
city: Summit
country: United States
facility: Research Site
state: New Jersey
city: Voorhees
country: United States
facility: Research Site
state: New Jersey
city: West Orange
country: United States
facility: Research Site
state: New Jersey
city: Albuquerque
country: United States
facility: Research Site
state: New Mexico
city: Albany
country: United States
facility: Research Site
state: New York
city: Brooklyn
country: United States
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state: New York
city: Hawthorne
country: United States
facility: Research Site
state: New York
city: Johnson City
country: United States
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state: New York
city: Liverpool
country: United States
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state: New York
city: New York
country: United States
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state: New York
city: New York
country: United States
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state: New York
city: New York
country: United States
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state: New York
city: Poughkeepsie
country: United States
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state: New York
city: Saratoga Springs
country: United States
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state: New York
city: The Bronx
country: United States
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city: The Bronx
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city: Troy
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city: Williamsville
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city: Chapel Hill
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city: Charlotte
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city: Concord
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city: Greensboro
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state: North Carolina
city: High Point
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city: Lenoir
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state: North Carolina
city: Raleigh
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city: Raleigh
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city: Winston-Salem
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city: Fargo
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state: North Dakota
city: Fargo
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city: Oklahoma City
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city: Oklahoma City
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state: Oklahoma
city: Hillsboro
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city: Doylestown
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city: Erie
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city: Hershey
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city: Langhorne
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city: Newport
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city: Philadelphia
country: United States
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state: Pennsylvania
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state: Pennsylvania
city: Philadelphia
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city: Pawtucket
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city: Columbia
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city: Jackson
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city: Knoxville
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city: Memphis
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city: Nashville
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city: Austin
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city: Salt Lake City
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facility: Research Site
city: Zilina
country: Slovakia
facility: Research Site
city: Albacete
country: Spain
facility: Research Site
city: Alcorcón
country: Spain
facility: Research Site
city: Alicante
country: Spain
facility: Research Site
city: Badalona (Barcelona)
country: Spain
facility: Research Site
city: Badalona(Barcelona)
country: Spain
facility: Research Site
city: Barcelona
country: Spain
facility: Research Site
city: Barcelona
country: Spain
facility: Research Site
city: Boadilla del Monte
country: Spain
facility: Research Site
city: Coruña
country: Spain
facility: Research Site
city: Getafe
country: Spain
facility: Research Site
city: Granada
country: Spain
facility: Research Site
city: Hospitalet de Llobregat(Barcel
country: Spain
facility: Research Site
city: Huelva
country: Spain
facility: Research Site
city: Lérida
country: Spain
facility: Research Site
city: Madrid
country: Spain
facility: Research Site
city: Madrid
country: Spain
facility: Research Site
city: Madrid
country: Spain
facility: Research Site
city: Madrid
country: Spain
facility: Research Site
city: Mallorca
country: Spain
facility: Research Site
city: Manises
country: Spain
facility: Research Site
city: Málaga
country: Spain
facility: Research Site
city: Oviedo
country: Spain
facility: Research Site
city: Sabadell
country: Spain
facility: Research Site
city: Tarragona
country: Spain
facility: Research Site
city: Toledo
country: Spain
facility: Research Site
city: Valencia
country: Spain
facility: Research Site
city: Valencia
country: Spain
facility: Research Site
city: Eksjö
country: Sweden
facility: Research Site
city: Gävle
country: Sweden
facility: Research Site
city: Göteborg
country: Sweden
facility: Research Site
city: Karlstad
country: Sweden
facility: Research Site
city: Malmö
country: Sweden
facility: Research Site
city: Stockholm
country: Sweden
facility: Research Site
city: Stockholm
country: Sweden
facility: Research Site
city: Uppsala
country: Sweden
facility: Research Site
city: Västerås
country: Sweden
facility: Research Site
city: Örebro
country: Sweden
facility: Research Site
city: Bangkoknoi
country: Thailand
facility: Research Site
city: Bangkok
country: Thailand
facility: Research Site
city: Bangkok
country: Thailand
facility: Research Site
city: Muang
country: Thailand
facility: Research Site
city: Songkla
country: Thailand
facility: Research Site
city: Ankara
country: Turkey
facility: Research Site
city: Ankara
country: Turkey
facility: Research Site
city: Ankara
country: Turkey
facility: Research Site
city: Bursa
country: Turkey
facility: Research Site
city: Bursa
country: Turkey
facility: Research Site
city: Istanbul
country: Turkey
facility: Research Site
city: Istanbul
country: Turkey
facility: Research Site
city: Istanbul
country: Turkey
facility: Research Site
city: Istanbul
country: Turkey
facility: Research Site
city: Izmir
country: Turkey
facility: Research Site
city: Izmir
country: Turkey
facility: Research Site
city: Malatya
country: Turkey
facility: Research Site
city: Ivano-Frankivsk
country: Ukraine
facility: Research Site
city: Ivano-Frankivsk
country: Ukraine
facility: Research Site
city: Kharkiv
country: Ukraine
facility: Research Site
city: Kharkiv
country: Ukraine
facility: Research Site
city: Kharkiv
country: Ukraine
facility: Research Site
city: Kyiv
country: Ukraine
facility: Research Site
city: Kyiv
country: Ukraine
facility: Research Site
city: Kyiv
country: Ukraine
facility: Research Site
city: Odesa
country: Ukraine
facility: Research Site
city: Uzhgorod
country: Ukraine
facility: Research Site
city: Vinnytsia
country: Ukraine
facility: Research Site
city: Zaporizhzhya
country: Ukraine
facility: Research Site
city: Zaporizhzhya
country: Ukraine
facility: Research Site
city: Zaporizhzhya
country: Ukraine
facility: Research Site
city: Zaporizhzhya
country: Ukraine
facility: Research Site
city: Aberdeen
country: United Kingdom
facility: Research Site
city: Birmingham
country: United Kingdom
facility: Research Site
city: Bournemouth
country: United Kingdom
facility: Research Site
city: Cambridge
country: United Kingdom
facility: Research Site
city: Cheltenham
country: United Kingdom
facility: Research Site
city: Dundee
country: United Kingdom
facility: Research Site
city: Hull
country: United Kingdom
facility: Research Site
city: Leeds
country: United Kingdom
facility: Research Site
city: Leicester
country: United Kingdom
facility: Research Site
city: London
country: United Kingdom
facility: Research Site
city: Newcastle upon TYNE
country: United Kingdom
facility: Research Site
city: Worcester
country: United Kingdom
facility: Research Site
city: Hanoi
country: Vietnam
facility: Research Site
city: Hcmc
country: Vietnam
facility: Research Site
city: Ho Chi Minh
country: Vietnam
facility: Research Site
city: Ho Chi Minh
country: Vietnam
facility: Research Site
city: Hochiminh
country: Vietnam
facility: Research Site
Study officials:
affiliation: University of Colorado School of Medicine
name: William R Hiatt, MD
role: STUDY_CHAIR
affiliation: AstraZeneca
name: Peter Held, MD
role: STUDY_DIRECTOR
References:
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citation: Govsyeyev N, Nehler MR, Low Wang CC, Kavanagh S, Hiatt WR, Long C, Jones WS, Fowkes FGR, Berger JS, Baumgartner I, Patel MR, Goodney PP, Beckman JA, Katona BG, Mahaffey KW, Blomster J, Norgren L, Bonaca MP. Etiology and outcomes of amputation in patients with peripheral artery disease in the EUCLID trial. J Vasc Surg. 2022 Feb;75(2):660-670.e3. doi: 10.1016/j.jvs.2021.08.096. Epub 2021 Sep 28.
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citation: Hsia J, Kavanagh ST, Hopley CW, Baumgartner I, Berger JS, Fowkes GR, Jones WS, Mahaffey KW, Norgren L, Patel MR, Rockhold F, Blomster J, Katona BG, Hiatt WR, Bonaca MP. Impact of chronic kidney disease on hemoglobin among patients with peripheral artery disease treated with P2Y12 inhibitors: Insights from the EUCLID trial. Vasc Med. 2021 Dec;26(6):608-612. doi: 10.1177/1358863X211017641. Epub 2021 Jun 3.
citation: Galani J, Mulder H, Rockhold FW, Weissler EH, Baumgartner I, Berger JS, Blomster JI, Fowkes FGR, Hiatt WR, Katona BG, Norgren L, Mahaffey KW, Quint JK, Patel MR, Jones WS. Association of Chronic Obstructive Pulmonary Disease with Morbidity and Mortality in Patients with Peripheral Artery Disease: Insights from the EUCLID Trial. Int J Chron Obstruct Pulmon Dis. 2021 Mar 29;16:841-851. doi: 10.2147/COPD.S292978. eCollection 2021.
citation: Kochar A, Mulder H, Rockhold FW, Baumgartner I, Berger JS, Blomster JI, Fowkes FGR, Katona BG, Lopes RD, Al-Khalidi HR, Mahaffey KW, Norgren L, Hiatt WR, Patel MR, Jones WS. Cause of Death Among Patients With Peripheral Artery Disease: Insights From the EUCLID Trial. Circ Cardiovasc Qual Outcomes. 2020 Nov;13(11):e006550. doi: 10.1161/CIRCOUTCOMES.120.006550. Epub 2020 Nov 12.
citation: Gutierrez JA, Heizer GM, Jones WS, Rockhold FW, Mahaffey KW, Fowkes FGR, Berger JS, Baumgartner I, Held P, Katona BG, Norgren L, Blomster JI, Hiatt WR, Patel MR. CYP2C19 status and risk of major adverse cardiovascular events in peripheral artery disease: Insights from the EUCLID Trial. Am Heart J. 2020 Nov;229:118-120. doi: 10.1016/j.ahj.2020.07.017. Epub 2020 Aug 16. No abstract available.
citation: Fudim M, Hopley CW, Huang Z, Kavanagh S, Rockhold FW, Baumgartner I, Berger JS, Blomster JI, Fowkes FGR, Katona BG, Mahaffey KW, Norgren L, Ostrom C, Patel MR, Jones WS, Hiatt WR. Association of Hypertension and Arterial Blood Pressure on Limb and Cardiovascular Outcomes in Symptomatic Peripheral Artery Disease: The EUCLID Trial. Circ Cardiovasc Qual Outcomes. 2020 Sep;13(9):e006512. doi: 10.1161/CIRCOUTCOMES.120.006512. Epub 2020 Aug 31.
citation: Long CA, Mulder H, Fowkes FGR, Baumgartner I, Berger JS, Katona BG, Mahaffey KW, Norgren L, Blomster JI, Rockhold FW, Hiatt WR, Patel MR, Jones WS, Nehler MR. Incidence and Factors Associated With Major Amputation in Patients With Peripheral Artery Disease: Insights From the EUCLID Trial. Circ Cardiovasc Qual Outcomes. 2020 Jul;13(7):e006399. doi: 10.1161/CIRCOUTCOMES.119.006399. Epub 2020 Jul 3.
citation: Haine A, Kavanagh S, Berger JS, Hess CN, Norgren L, Fowkes FGR, Katona BG, Mahaffey KW, Blomster JI, Patel MR, Jones WS, Rockhold FW, Hiatt WR, Baumgartner I; International Steering Committee and Investigators of the EUCLID Trial. Sex-Specific Risks of Major Cardiovascular and Limb Events in Patients With Symptomatic Peripheral Artery Disease. J Am Coll Cardiol. 2020 Feb 18;75(6):608-617. doi: 10.1016/j.jacc.2019.11.057.
citation: Ward R, Huang Z, Rockhold FW, Baumgartner I, Berger JS, Blomster JI, Fowkes FGR, Katona BG, Mahaffey KW, Norgren L, Vemulapalli S, Povsic TJ, Mehta R, Hiatt WR, Patel MR, Jones WS. Major bleeding in patients with peripheral artery disease: Insights from the EUCLID trial. Am Heart J. 2020 Feb;220:51-58. doi: 10.1016/j.ahj.2019.11.007. Epub 2019 Nov 18.
citation: Hopley CW, Kavanagh S, Patel MR, Ostrom C, Baumgartner I, Berger JS, Blomster JI, Fowkes FGR, Jones WS, Katona BG, Mahaffey KW, Norgren L, Rockhold FW, Hiatt WR. Chronic kidney disease and risk for cardiovascular and limb outcomes in patients with symptomatic peripheral artery disease: The EUCLID trial. Vasc Med. 2019 Oct;24(5):422-430. doi: 10.1177/1358863X19864172. Epub 2019 Jul 24.
citation: Hess CN, Huang Z, Patel MR, Baumgartner I, Berger JS, Blomster JI, Fowkes FGR, Held P, Jones WS, Katona B, Mahaffey KW, Norgren L, Rockhold FW, Hiatt WR. Acute Limb Ischemia in Peripheral Artery Disease. Circulation. 2019 Aug 13;140(7):556-565. doi: 10.1161/CIRCULATIONAHA.119.039773. Epub 2019 Jun 26.
citation: Kolls BJ, Sapp S, Rockhold FW, Jordan JD, Dombrowski KE, Fowkes FGR, Mahaffey KW, Berger JS, Katona BG, Blomster JI, Norgren L, Abramson BL, Leiva-Pons JL, Prieto JC, Sokurenko G, Hiatt WR, Jones WS, Patel MR. Stroke in Patients With Peripheral Artery Disease. Stroke. 2019 Jun;50(6):1356-1363. doi: 10.1161/STROKEAHA.118.023534. Epub 2019 May 16.
citation: Low Wang CC, Blomster JI, Heizer G, Berger JS, Baumgartner I, Fowkes FGR, Held P, Katona BG, Norgren L, Jones WS, Lopes RD, Olin JW, Rockhold FW, Mahaffey KW, Patel MR, Hiatt WR; EUCLID Trial Executive Committee and Investigators. Cardiovascular and Limb Outcomes in Patients With Diabetes and Peripheral Artery Disease: The EUCLID Trial. J Am Coll Cardiol. 2018 Dec 25;72(25):3274-3284. doi: 10.1016/j.jacc.2018.09.078.
citation: Olivier CB, Mulder H, Hiatt WR, Jones WS, Fowkes FGR, Rockhold FW, Berger JS, Baumgartner I, Held P, Katona BG, Norgren L, Blomster J, Patel MR, Mahaffey KW. Incidence, Characteristics, and Outcomes of Myocardial Infarction in Patients With Peripheral Artery Disease: Insights From the EUCLID Trial. JAMA Cardiol. 2019 Jan 1;4(1):7-15. doi: 10.1001/jamacardio.2018.4171.
citation: Baumgartner I, Norgren L, Fowkes FGR, Mulder H, Patel MR, Berger JS, Jones WS, Rockhold FW, Katona BG, Mahaffey K, Hiatt WR; Executive Committee and Investigators of the EUCLID Trial. Cardiovascular Outcomes After Lower Extremity Endovascular or Surgical Revascularization: The EUCLID Trial. J Am Coll Cardiol. 2018 Oct 2;72(14):1563-1572. doi: 10.1016/j.jacc.2018.07.046.
citation: Berger JS, Abramson BL, Lopes RD, Heizer G, Rockhold FW, Baumgartner I, Fowkes FGR, Held P, Katona BG, Norgren L, Jones WS, Millegard M, Blomster J, Reist C, Hiatt WR, Patel MR, Mahaffey KW. Ticagrelor versus clopidogrel in patients with symptomatic peripheral artery disease and prior coronary artery disease: Insights from the EUCLID trial. Vasc Med. 2018 Dec;23(6):523-530. doi: 10.1177/1358863X18775594. Epub 2018 Jul 11.
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citation: Hiatt WR, Fowkes FG, Heizer G, Berger JS, Baumgartner I, Held P, Katona BG, Mahaffey KW, Norgren L, Jones WS, Blomster J, Millegard M, Reist C, Patel MR; EUCLID Trial Steering Committee and Investigators. Ticagrelor versus Clopidogrel in Symptomatic Peripheral Artery Disease. N Engl J Med. 2017 Jan 5;376(1):32-40. doi: 10.1056/NEJMoa1611688. Epub 2016 Nov 13.
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citation: Held P, Himmelmann A, Ditmarsch M. Ticagrelor for the treatment of atherosclerotic disease: insights from the PARTHENON clinical development program. Future Cardiol. 2016 Jul;12(4):405-18. doi: 10.2217/fca-2016-0028. Epub 2016 May 10.