Clinical trial NCT06783075: Milk Vs Wheat Protein Intake to Maximize Whole-body Protein Synthesis Rates in Healthy Older Adults
Official title: Milk Vs Wheat Protein Intake to Maximize Whole-body Protein Synthesis Rates in Healthy Older Adults
Study type: INTERVENTIONAL
Overall status: NOT_YET_RECRUITING
Phase: NA
Conditions: Protein Metabolism
Keywords: whole-body protein synthesis
Lead sponsor: Maastricht University Medical Center
Sponsor class: OTHER
First posted: 2025-01-20
Enrollment: 24
Sex: ALL
Minimum age (years): 65
Maximum age (years): 85
Standard ages: OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Intervention model description: Double-blind, randomized, parallel study design
Primary purpose: BASIC_SCIENCE

Brief summary: Dietary protein intake is essential for tissue renewal and growth. Current recommendations for protein intake are based on studies using egg protein as reference protein. Egg protein is an animal-based protein with a high quality. Protein quality is determined by the composition of (essential) amino acids and digestibility. Therefore, different proteins have a different quality. Due to the environmental crisis, an increasing number of people consumes more plant-based proteins. These plant-based proteins often have a lower protein quality compared to animal-based proteins. Therefore, the aim of this study is to investigate whether optimal protein intake depend on protein quality. The optimal protein intake of an animal-based protein with a high quality (milk) will be compared to the optimal protein intake of a plant-based protein with a low quality (wheat).


Eligibility criteria: Inclusion Criteria:

* Aged between 65-85 years
* BMI between 18.5-30 kg\*m\^-2
* Healthy, recreationally active (maximal one intensive exercise training per week)
* No physical limitations (i.e., able to perform all activities associated with daily living independently)

Exclusion Criteria:

* Smoking
* Diagnosed musculoskeletal disorders
* Use of any medications known to affect protein metabolism (i.e., corticosteriods, non-steroidal anti-inflammatories)
* Chronic use of gastic acid-suppressing medication or anti-coagulants
* Unstable weight over the last 3 months
* Diagnosed GI tract disorders or diseases
* Blood donation in the past 2 months

Primary outcomes:
measure: Differences in protein intake to maximize whole-body protein synthesis rates in older adults based on consumption of milk protein or wheat protein
timeFrame: From enrollment to the end of the study at 7 weeks
Secondary outcomes:
measure: Estimated Average Requirement (EAR) to maximize whole-body protein synthesis rates in healthy older adults based on milk protein
timeFrame: From enrollment to the end of the study at 7 weeks
measure: The Recommended Daily Allowance (RDA) to maximize whole-body protein synthesis rates in older adults based on milk protein
timeFrame: From enrollment to the end of the study at 7 weeks
measure: The Estimated Average Requirement (EAR) to maximize whole-body protein synthesis rates in older adults based on wheat protein
timeFrame: From enrollment to the end of the study at 7 weeks
measure: The Recommended Daily Allowance (RDA) to maximize whole-body protein synthesis rates in older adults based on wheat protein
timeFrame: From enrollment to the end of the study at 7 weeks
Other outcomes:
Locations:
city: Maastricht
country: Netherlands
facility: Maastricht University Medical Center+
state: Limburg
Study officials:
References: