Clinical trial NCT02118649: Enhancing Behavior and Brain Response to Visual Targets Using a Computer Game
Study type: INTERVENTIONAL
Overall status: ACTIVE_NOT_RECRUITING
Phase: NA
Conditions: Neurodevelopmental Disorders
Lead sponsor: Yale University
Sponsor class: OTHER
First posted: 2014-04-21
Enrollment: 100
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: TREATMENT

Brief summary: Participants will play a computer game that is controlled by their gaze patterns and designed to direct attention their attention to specific on-screen targets. Visual attention to targets will be rewarded. Both visual behavior and brain response will be recorded during game play.

It is hypothesized that that, over the course of the game, relative to baseline, participants will show (a) increased looking to targets, (b) decreased response time to targets, and (c) enhanced, more efficient neural response to visual cues. It is hypothesized that clinical variability will associate with visual attention and brain response.


Eligibility criteria: Inclusion Criteria:

* Able to participate in an eye-tracking experiment
* Able to participate in an EEG experiment

Exclusion Criteria:

* Sensory or physical impairment that would preclude completion of protocol
* Participants taking prescription medications that may affect cognitive processes
* Participants reporting significant head trauma or history of seizures

Primary outcomes:
measure: EEG brain response to targets
timeFrame: Measures will be recorded for the duration of their visit, an expected average of 3 hours.
Secondary outcomes:
measure: Visual attention to targets as measured by eye-tracking
timeFrame: Measures will be recorded for the duration of their visit, an expected average of 3 hours.
measure: Social Responsiveness Scale, Second Edition
timeFrame: Measures will be collected during visit, an expected average of 3 hours.
measure: Autism Diagnostic Observation Schedule
timeFrame: Measures will be collected during visit, an expected average of 3 hours.
measure: Differential Abilities Scale
timeFrame: Measures will be collected during visit, an expected average of 3 hours.
measure: Vineland Adaptive Behavior Scales, Second Edition
timeFrame: Measures will be collected during visit, an expected average of 3 hours.
measure: Social Anxiety Scale for Children, Revised
timeFrame: Measures will be collected during visit, an expected average of 3 hours.
Other outcomes:
Locations:
city: New Haven
country: United States
facility: Yale Child Study Center
state: Connecticut
Study officials:
References:
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