Clinical trial NCT00833300: Haloperidol vs Olanzapine for the Management of ICU Delirium
Official title: Haloperidol vs Olanzapine for the Management of ICU Delirium: A Randomized Clinical Trial
Study type: INTERVENTIONAL
Overall status: TERMINATED
Phase: NA
Conditions: Delirium
Agitation
Keywords: Delirium
Agitation
Intensive Care
Critical Care
Antipsychotics
Olanzapine
Haloperidol
Lead sponsor: Nova Scotia Health Authority
Sponsor class: OTHER
Collaborators: name: Dalhousie University
First posted: 2009-02-02
Enrollment: 200
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The purpose of this randomized clinical trial is to determine whether haloperidol is superior to olanzapine for the treatment of ICU acquired delirium. The hypothesis is that haloperidol is in fact superior to olanzapine in treating ICU acquired delirium and sustaining delirium free time.

Detailed description: Delirium is defined as a disturbance of consciousness characterized by an acute onset of impaired cognitive function. Although delirium is thought to be common in the Intensive Care Unit (ICU) there are few studies that have evaluated its incidences, risks and outcomes. It has been associated with increased morbidity, and mortality and increased cost to the healthcare system. In addition to the uncertainty of the incidence of ICU delirium, there is a lack of information about the effects that certain pharmacological treatments have on delirious patients.

The standard pharmacological treatments for ICU acquired delirium are haloperidol and olanzapine as they have been shown to be equivalent in reducing its incidence. However, optimal dose and regimen have not been well defined.

The rationale for this study is to determine whether haloperidol is superior to olanzapine in the treatment of ICU acquired delirium. A secondary objective is to determine the most appropriate dosing regimen for the treatmet. The role of alternative agents quetiapine, risperidone, loxapine and methotrimeprazine will also be examined in a preliminary analysis.

Patients who develop agitation or delirium as defined by an Intensive Care Delirium Checklist (ICDSC) score of greater than or equal to 4 meeting all the inclusion criteria and no exclusion criteria will be eligible for randomization. Once randomized they will be screened for ongoing agitation and delirium as well prolongation of the QTc interval greater than 440 msec, development of extrapyramidal symptoms and development of a seizure disorder.

Eligibility criteria: Inclusion Criteria:

* All patients who are 18 years or older who are admitted for more than 24 hours to the ICU.
* Patients screened for delirium using the ICDSC with a score greater than or equal to 4 or with clinical manifestations of delirium.

Exclusion Criteria:

* Patients unlikely to survive 24 hours.
* Patients with a primary neurologic reason (i.e. stroke, dementia-related psychosis) for ICU admission.
* Patients with QTc interval greater than 440 msec.
* Pregnant patients.
* Patients who are breast feeding.
* Patients in whom haloperidol, or olanzapine is contraindicated.
* Patients allergic to haloperidol, olanzapine, quetiapine, risperidone, loxapine or methotrimeprazine.
* Patients who do not have a urinary catheter.
* Patients who have received haloperidol, olanzapine, quetiapine, risperidone, loxapine or methotrimeprazine within 14 days.
* Patients unable to undergo assessment (i.e. patients with developmental disability or mental incapacity prior to ICU admission).
* Prolonged (greather than 24 hours) comatose patients who have a defined structural reason for their decreased level of consciousness.

Primary outcomes:
measure: Resolution of delirium as indicated by an Intensive Care Delirium Screening Checklist score of less than 4
timeFrame: Every 24 hours
Secondary outcomes:
measure: Delirium free days (i.e. time from resolution of delirium to ICU discharge)
timeFrame: Every 24 hours
measure: Incidence of treatment failure at 48 hours
timeFrame: 48 hours
measure: Requirement for rescue medication
timeFrame: Every 24 hours
measure: Type of rescue medication
timeFrame: Every 24 hours
measure: Mortality
timeFrame: Time of death
measure: If on mechanical ventilation at time delirium develops, duration of mechanical ventilation
timeFrame: Every 24 hours
Other outcomes:
Locations:
city: Halifax
country: Canada
facility: Halifax Infirmary; Queen Elizabeth II Health Sciences Centre
state: Nova Scotia
city: Halifax
country: Canada
facility: Victoria General Hospital; Queen Elizabeth II Health Sciences Centre
state: Nova Scotia
Study officials:
affiliation: Nova Scotia Health Authority
name: Richard Hall, MD, FRCPC, FCCP
role: PRINCIPAL_INVESTIGATOR
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