louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT04275752: Exercise Intervention on Frailty After Kidney Transplantation
Official title: Examining the Preliminary Efficacy, Feasibility, and Acceptability of an Exercise Intervention on Frailty After Kidney Transplantation
Study type: INTERVENTIONAL
Overall status: WITHDRAWN
Phase: NA
Conditions: Kidney Transplant
Lead sponsor: Mayo Clinic
Sponsor class: OTHER
Collaborators: name: National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
First posted: 2020-02-19
Enrollment: 0
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: SUPPORTIVE_CARE

Brief summary: Researchers are trying to determine if exercise will improve health and strength in kidney transplant patients.


Eligibility criteria: Inclusion Criteria:

* Patients age ≥ 18 years who have received a KT and have a functioning allograft

Exclusion Criteria:

* Neuropsychiatric condition causing patient to be unable to provide consent
* Recipient of a combined organ transplant

Primary outcomes:
measure: Change in frailty status
timeFrame: Two months
Secondary outcomes:
Other outcomes:
Locations:
city: Rochester
country: United States
facility: Mayo Clinic in Rochester
state: Minnesota
Study officials:
affiliation: Mayo Clinic
name: Elizabeth Lorenz, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT06223152: Evaluation of the Effectiveness of a Guidance Program for Parents of Deaf Children
Official title: Evaluation of the Effectiveness of a Guidance Program for Parents of Deaf Children
Study type: INTERVENTIONAL
Overall status: SUSPENDED
Phase: NA
Conditions: Deaf Nonspeaking, Not Elsewhere Classified
Keywords: deaf children
communication
language parental support
Lead sponsor: Université Catholique de Louvain
Sponsor class: OTHER
First posted: 2024-01-25
Enrollment: 10
Sex: ALL
Minimum age (years): 18
Maximum age (years): 4
Standard ages: CHILD
Accepts healthy volunteers: yes
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: TREATMENT

Brief summary: The purpose of this project is to evaluate the effectiveness of a parent guidance program on (1) the parent's communication skills, (2) the parent's sense of competence and (3) the child's language development. Concretely, 11 guidance sessions will be offered to parents by alternating two group sessions (in a common place) and one family session (at home). These sessions will be given every week and will last approximately 2 hours. The sessions will focus on working on and learning adult attitudes conducive to the development of communication and language in the child. These sessions will be interactive through questions (wooclap), exchanges, video illustrations, role playing, etc. A practical application will be proposed in daily life with the help of the video-feedback technique during the home sessions, individually with the parent.

The effectiveness of this intervention will be evaluated via a pre- and post-test conducted in the families' homes. Episodes of parent-child interactions in a play situation will be filmed and coded in order to assess the parents' communication skills (receptivity, reactivity, language support strategies, etc.). The feeling of parental competence as well as the child's language will be estimated using parent questionnaires.

The investigators hypothesize that parent guidance sessions will have an effect on the communication skills of parents of deaf children and will indirectly improve their sense of parenting competence as well as the child's language development. This study will therefore offer avenues for adapting the support of families of deaf children.


Eligibility criteria: Inclusion Criteria:

* deaf children and parents
* 18 months - 4 years

Exclusion Criteria:

-

Primary outcomes:
measure: Communication between parent and child
timeFrame: troughout the entire study, an average of 40 months
measure: Child's language development
timeFrame: troughout the entire study, an average of 40 months
measure: Questionnaires assessing the feeling of parental competence
timeFrame: troughout the entire study, an average of 40 months
Secondary outcomes:
Other outcomes:
Locations:
city: Louvain-la-Neuve
country: Belgium
facility: Bragard
Study officials:
References:
Clinical trial NCT05433870: Inflammatory Biomarkers for the Diagnosis of oPRES
Official title: Inflammatory Biomarkers for the Diagnosis of Obstetric Posterior Reversible Encephalopathy Syndrome
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Posterior Reversible Encephalopathy Syndrome
Inflammatory Biomarkers
Neutrophil-lymphocyte Ratio
Lead sponsor: Guangzhou Medical University
Sponsor class: OTHER
First posted: 2022-06-27
Enrollment: 621
Sex: FEMALE
Minimum age (years): 16
Maximum age (years): 50
Standard ages: CHILD
ADULT
Accepts healthy volunteers: no
Observational model: CASE_ONLY
Time perspective: RETROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Pregnant Women diagnosed with PE or E.

Brief summary: The purpose of this study is to explore the inflammatory biomarkers for the diagnosis of obstetric posterior reversible encephalopathy syndrome.

Detailed description: The investigators retrospectively collected data (General information, clinical data, biochemical indicators, imaging features, and pregnancy outcome) from pregnant woman diagnosed with PRES to explore the inflammatory biomarkers for the diagnosis of oPRES during 2012 to 2021.Then, the investigators grouped all the patients into PRES group (PE or E with PRES) and NOT-PRES group (PE or E without PRES) according to the diagnostic criteria of PRES. Then, the investigators analysed the inflammatory biomarkers, such as neutrophil-lymphocyte ratio (NLR), platelet-lymphocyte ratio (PLR), monocyte-lymphocyte ratio (MLR), and so on of two groups, and compared the difference of tow groups.

Eligibility criteria: Inclusion Criteria:

1. Pregnant women were diagnosed of PE or E.
2. All patients were examined the cranial imaging (MRI or CT), and imaging findings meeting the diagnostic criteria of PRES or normal.
3. all patients provided written informed consent.

Exclusion Criteria:

1. patients combined with other neurological disorders
2. patients combined with mental illness

Primary outcomes:
measure: inflammatory biomarkers
timeFrame: Inflammatory biomarkers were collected within 1 day after the onset of symptoms.
measure: cranial Imaging
timeFrame: Cranial Imaging was examined within 3 days after the onset of symptoms, such as s headaches, visual changes, seizures, consciousness impairment.
Secondary outcomes:
measure: other biochemical parameters
timeFrame: biochemical parameters were collected within 1 week of the hospital stay.
measure: Blood Pressure(BP)
timeFrame: The BP of patients was obtained within 1hour after the onset of symptoms.
measure: pregnancy outcomes
timeFrame: The pregnancy outcomes will record immediately when the patients deliver.
Other outcomes:
Locations:
city: Guangzhou
country: China
facility: Department of Obstetrics and Gynecology, Key Laboratory for Major Obstetric Diseases of Guangdong Province, The Third Affiliated Hospital of Guangzhou Medical University
Study officials:
affiliation: The Third Affiliated Hospital of Guangzhou Medical University
name: Dunjin Chen
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT01256970: The Study of Polycystic Ovary Syndrome (PCOS) and Questionnaire
Official title: The Study of Polycystic Ovary Syndrome (PCOS) and Questionnaire
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Polycystic Ovary Syndrome
Lead sponsor: Taipei Medical University WanFang Hospital
Sponsor class: OTHER
First posted: 2010-12-09
Enrollment: 306
Sex: FEMALE
Minimum age (years): 15
Maximum age (years): 45
Standard ages: CHILD
ADULT
Accepts healthy volunteers: yes
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: Polycystic Ovary Syndrome(PCOS)

Brief summary: Polycystic ovary syndrome (PCOS) is an extremely common disorder in women of reproductive age. Diagnosis of PCOS is principally based on clinical and physical findings. Diagnostic criteria and PCOS definitions used by clinicians and researchers are almost as heterogeneous as the syndrome. This first part of study is determine whether genetic polymorphisms influence hormonal and metabolic characteristics in Taiwanese patients with PCOS and controls. Furthermore, women with PCOS were reported with high risk of cardiovascular disease, the investigators planned to calculate the difference of carotid intima-media thickness (IMT) and B-type natriuretic peptide (BNP) between women with PCOS and normal control to determine the premature atherosclerosis of women with PCOS.


Eligibility criteria: Inclusion Criteria:

* women at reproductive age
* women with PCOS and women without PCOS

Exclusion Criteria:

* young women who had their menarche less than 3 years
* women older than 45 years old, Amenorrhea of menopause, hyperglycemia, hyperthyroidism, hypothyroidism, heart failure, lung failure, renal failure, anemia, dystrophy, gonitis

Primary outcomes:
measure: Obesity is the predominant predictor of impaired glucose tolerance and metabolic disturbance in polycystic ovary syndrome.
timeFrame: Prospectively study in University teaching hospital from 31 August 2010 to 31 August 2011.
Secondary outcomes:
Other outcomes:
Locations:
city: Taipei
country: Taiwan
facility: Taipei Medical University-WanFang Hospital
Study officials:
affiliation: Taipei Medical University WanFang Hospital
name: Ming-I Hsu
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT04176770: Comparaison of ESP Block and TAP Block
Official title: ESP Versus TAP for Analgesia After Laparoscopic Cholecystectomy
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Post Operative Pain
Keywords: Laparoscopic cholecystectomy
Post Operative
Analgesia
Lead sponsor: Mongi Slim Hospital
Sponsor class: OTHER
First posted: 2019-11-25
Enrollment: 80
Sex: ALL
Minimum age (years): 18
Maximum age (years): 99
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: This study aim to compare the efficiency and the analgesic effect of Erector Spinal Plane Block versus TAP Block after laparoscopic cholecystectomy.

Detailed description: This study will include patients scheduled for laparoscopic cholecystectomy, ASA status 1 or 2. patients will be randomized in 2 groups to recieve post operative analgesia with -ESP block: bilateral injection of 20 ml of isobaric Bupivacain 0,375% in the paraverebral space T5.

or

-TAP block: bilateral injection of 15 ml of Isobaric Bupivacain 0,5%

Eligibility criteria: Inclusion Criteria:

* Adult patients
* ASA status I or II
* scheduled for laparoscopic cholecystectomy

Exclusion Criteria:

* laparotomy
* unplanned ICU admission

Primary outcomes:
measure: Post Operative analgesia
timeFrame: 24 hours after intervention
Secondary outcomes:
measure: post operative analgesic consumption
timeFrame: 24 hours after intervention
Other outcomes:
Locations:
city: Tunis
country: Tunisia
facility: Mongi Slim Hospital
Study officials:
affiliation: Mongi Slim Hospital
name: Mhamed Sami Mebazaa, Professor
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT01832870: Sipuleucel-T and Ipilimumab for Advanced Prostate Cancer
Official title: Phase 1 Study of Sipuleucel-T and Ipilimumab in Combination for Advanced Prostate Cancer
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE1
Conditions: Prostate Cancer
Castrate Resistant Prostate Cancer
Lead sponsor: Prostate Oncology Specialists, Inc.
Sponsor class: OTHER
First posted: 2013-04-16
Enrollment: 9
Sex: MALE
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: TREATMENT

Brief summary: This is a clinical trial designed to quantify the immune response and determine the tolerability and side effects of sipuleucel-T when given in combination with ipilimumab for patients with advanced prostate cancer.


Eligibility criteria: Inclusion Criteria:

* Subjects with advanced prostate cancer who are eligible to receive sipuleucel-T in accordance with FDA approved labeling of sipuleucel-T
* Subjects must understand and sign an informed consent form

Exclusion Criteria:

* Subjects who are not eligible to receive sipuleucel-T

Primary outcomes:
measure: Antigen-specific memory T cell response
timeFrame: After last sipuleucel-T and last ipilimumab, and follow-up period, an expected average of 15 months
measure: Antigen-specific T cell proliferation to PA2024, PAP and PHA
timeFrame: After last sipuleucel-T and last ipilimumab, and follow-up period, an expected average of 15 months
measure: Antibody responses against PA2024 and PAP
timeFrame: After last sipuleucel-T and last ipilimumab, and the follow-up period, an expected average of 15 months
Secondary outcomes:
measure: Prostate-Specific Antigen (PSA) doubling time
timeFrame: Duration of the study, an expected average of 18 months
measure: Time to PSA progression
timeFrame: Duration of the study, an expected average of 18 months
measure: Time to salvage therapy
timeFrame: Duration of the study, an expected average of 18 months
measure: Percentage PSA decline
timeFrame: Duration of the study, an expected average of 18 months
Other outcomes:
Locations:
city: Marina del Rey
country: United States
facility: Prostate Oncology Specialists, Inc.
state: California
Study officials:
affiliation: Prostate Oncology Specialists, Inc.
name: Mark Scholz, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT04712370: Conventional Caudal Block, Ultrasound Guided Caudal Block and Ultrasound Guided Erector Spinae Block for Pediatric Hip Surgery
Official title: Comparison of Conventional Caudal Block, Ultrasound Guided Caudal Block and Ultrasound Guided Erector Spinae Block for Pediatric Hip Surgery
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Conventional Caudal Block
Ultrasound Guided Caudal Block
Ultrasound Guided Erector Spinae Block
Pediatric Hip Surgery
Lead sponsor: Tanta University
Sponsor class: OTHER
First posted: 2021-01-15
Enrollment: 105
Sex: ALL
Minimum age (years): 4
Maximum age (years): 12
Standard ages: CHILD
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: This study will be conducted to compare the efficacy and safety of ultrasound guided erector spinae block , ultrasound guided caudal block and conventional caudal block for pain management after pediatric hip surgery.


Eligibility criteria: Inclusion Criteria:

* Both sex
* ASA physical activity I, II
* Age 4-12 years
* Admitted for elective hip surgery.

Exclusion Criteria:

* Parents refusal
* Children with severe systemic disease
* ASA III or IV
* Children with previous neurological or spinal anomaly, coagulation disorders
* History of premature birth
* Infection at the block injection site
* History of allergy to local anesthetics
* Bilateral hip surgery.

Primary outcomes:
measure: Degree of pain intensity
timeFrame: First 24 hours postoperative
Secondary outcomes:
measure: Changes in mean arterial blood pressure
timeFrame: Intraoperative and first 24 hours postoperative
measure: Changes in heart rate
timeFrame: Intraoperative and first 24 hours postoperative
measure: Amount of Analgesic required in the first day after surgery
timeFrame: First 24 hours postoperative
measure: Time to first rescue analgesic demand after surgery.
timeFrame: First 24 hours postoperative
measure: Success rate of block
timeFrame: Intraoperative duration
measure: Duration of performing the block
timeFrame: Intraoperative duration
measure: Incidence of complications
timeFrame: Intraoperative and first 24 hours postoperative
Other outcomes:
Locations:
city: Tanta
country: Egypt
facility: Tanta University Hospitals
state: ElGharbiaa
Study officials:
References:
Clinical trial NCT03726970: Effect of Metal Artifacts Reduction Orotocols and Electric Potential Difference on Metal Artifacts in Cone Beam Computed Tomography
Official title: Effect of Metal Artifacts Reduction Protocols and Tube Potential Difference on Metal Artifacts in Cone Beam Computed
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Metal Artifacts
Lead sponsor: Cairo University
Sponsor class: OTHER
First posted: 2018-11-01
Enrollment: 2
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: DIAGNOSTIC

Brief summary: The effect of metal artifacts reduction protocols and tube potential difference on the metallic artifacts in cone beam computed tomography

Detailed description: Our study is a quantitative as well as a qualitative assessment of the metal artifacts in the CBCT images in a bio models with multiple adjacent dental implants and single isolated implants , while using different MAR protocols inherited in the CBCT soft ware , as well as change in the tube potential difference of the CBCT unit

Eligibility criteria: Inclusion Criteria:

* bio models of a lower jaw Titanium implants Porcelain fused to metal crowns

Exclusion Criteria:

-

Primary outcomes:
measure: Dental implant linear measurement
timeFrame: 1 month
Secondary outcomes:
measure: Bone- implant interphase
timeFrame: 1 month
Other outcomes:
Locations:
city: Cairo
country: Egypt
facility: Marina Salib
state: Giza
Study officials:
affiliation: Cairo University
name: Mushira M Dahba, Doctorate
role: STUDY_DIRECTOR
References:
Clinical trial NCT02970370: Demographics, Clinical and Paraclinical Characteristics of Multiple Sclerosis in Egypt
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Multiple Sclerosis
Lead sponsor: Cairo University
Sponsor class: OTHER
First posted: 2016-11-22
Enrollment: 2752
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Radiologically isolated syndrome, Clinically isolated Syndrome , Multiple Sclerosis, Neuromyelitis optica spectrum disorders (NMOSD), MS mimics

Brief summary: The primary study aim is to depict the demographics, clinical and para clinical features of patients attending five tertiary referral multiple sclerosis (MS) centers in Egypt.

This requires effective and unified pooled registries to extract data from with a standardized, sufficient and high quality clinical, magnetic resonance imaging (MRI) data, neurophysiological data and body fluids.

Investigators want to shed light on the challenges that face both physicians and patients in the area of "diagnosis and treatment"


Eligibility criteria: Inclusion Criteria:

* Patients with MS/NMOSD or their mimics who sought advice in one of our centers even once

Exclusion Criteria:

* Patients with missing data in their records that couldn't be completed

Primary outcomes:
measure: portrayed phenotypes and para-clinical data of Egyptian Multiple Sclerosis Patients
timeFrame: 6 months
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
References:
Clinical trial NCT05874570: Doxycycline for Helicobacter Pylori Rescue Treatment
Official title: Doxycycline-containing Bismuth Quadruple Therapy for Helicobacter Pylori Rescue Treatment: a Randomized Controlled Trial
Study type: INTERVENTIONAL
Overall status: RECRUITING
Phase: PHASE4
Conditions: Helicobacter Pylori Infection
Keywords: Helicobacter pylori
rescue therapy
doxycycline
tetracycline
Lead sponsor: Shanghai Jiao Tong University School of Medicine
Sponsor class: OTHER
First posted: 2023-05-25
Enrollment: 368
Sex: ALL
Minimum age (years): 18
Maximum age (years): 70
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: Current guidelines have recommended classical bismuth-containing quadruple therapy including proton-pump inhibitor, bismuth, tetracycline, metronidazole as the empirical rescue therapy. However, tetracycline is clinically unavailable in China and the high frequency of adverse events of bismuth quadruple therapy often result in poor compliance, which limited the applicability of this recommendation. This study aimed to compare the efficacy and tolerability of a 14-day bismuth-containing quadruple rescue therapy in which tetracycline was replaced by doxycycline.


Eligibility criteria: Inclusion Criteria:

* Ability and willingness to participate in the study and to sign and give informed consent
* Confirmed H. pylori infection and with previous treatment failure

Exclusion Criteria:

* subjects naive to H. pylori treatment,
* under 18 or over 80 years old
* history of gastrectomy
* pregnant or lactating women
* severe systemic diseases or malignancy
* administration of antibiotics, bismuth, antisecretory drugs, or Chinese herb medicine in the preceding 8 weeks

Primary outcomes:
measure: Helicobacter pylori eradication rate
timeFrame: Six weeks after completion of therapy
Secondary outcomes:
measure: Rate of adverse effects
timeFrame: Within 7 days after completion of therapy
measure: Compliance rate
timeFrame: Within 7 days after completion of therapy
Other outcomes:
Locations:
city: Shanghai
country: China
facility: Renji Hospital, School of Medicine, Shanghai Jiao Tong University
state: Shanghai
Study officials:
References: