louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT05389670: Theta-burst Repetitive Transcranial Magnetic Stimulation (TBS) of the Right Inferior Frontal Gyrus for Treatment of Nicotine Dependence
Official title: Theta-burst Repetitive Transcranial Magnetic Stimulation (TBS) of the Right Inferior Frontal Gyrus for Treatment of Nicotine Dependence
Study type: INTERVENTIONAL
Overall status: NOT_YET_RECRUITING
Phase: NA
Conditions: Tobacco Use Disorder
Lead sponsor: University of Missouri-Columbia
Sponsor class: OTHER
First posted: 2022-05-25
Enrollment: 60
Sex: ALL
Minimum age (years): 18
Maximum age (years): 65
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: BASIC_SCIENCE

Brief summary: The purpose of this research study is to examine the effects of theta-burst Transcranial Magnetic Stimulation on inhibitory control and smoking among adult cigarette smokers. In a double-blind, sham controlled trial, investigators will examine the effects of 12 sessions of cTBS on executive function and smoking behavior.


Eligibility criteria: Inclusion Criteria:

1. 18-65 yrs. of age
2. Smoke \> 5 cigarettes/day for ≥ 2 yrs, and expired carbon monoxide (CO) concentration of ≥ 8 ppm
3. English Fluency
4. Functional Vision (with corrective lenses as needed)

Exclusion Criteria:

1. Use of psychotropic and antiepileptic medications in the last month
2. Presence of an untreated illness or serious medical condition
3. History of major neurological illness
4. Contraindication to TMS (history of neurological disorder or seizure, increased intracranial pressure, brain surgery, or head trauma with loss of consciousness for \>15 min., implanted electronic device, metal in the head)
5. Any use of substances that lower seizure threshold
6. Current or past psychosis
7. Electroconvulsive therapy in last 6 months
8. Unstable cardiac disease or hypertension, severe renal or liver insufficiency, or sleep apnea
9. BAC greater than 0.0.
10. Positive urine pregnancy test
11. Any other concern that in the investigator's opinion would impact participant safety, study instruction compliance, or confound the interpretation of the study results

Primary outcomes:
measure: Change in the number (#) of cigarettes per day.
timeFrame: 2 months
measure: Cigarette craving scores (#) as measured by the questionnaire of smoking urges brief (QSUb).
timeFrame: 2 months
measure: Percent (%) correct on an inhibitory control GoGo/NoGo task.
timeFrame: 2 months
measure: Craving regulation scores (#) on a regulation of craving task.
timeFrame: 2 months
Secondary outcomes:
measure: Symptoms scores (#) as measured by the review of symptoms (ROS) questionnaire.
timeFrame: 2 months
Other outcomes:
Locations:
Study officials:
References:
Clinical trial NCT03164070: Study of the Laboratory-based Evaluation of the Degrees of Activity of Osteoarthritis
Official title: Study of the Laboratory-based Evaluation of the Degrees of Activity of Medium and Large Joint Osteoarthritis
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Osteoarthritis
Keywords: Osteoarthritis
Flow cytometry
Synovial fluid
Lead sponsor: The Republican Research and Practical Center for Epidemiology and Microbiology
Sponsor class: OTHER
Collaborators: name: Belarusian Medical Academy of Post-Graduate Education
First posted: 2017-05-23
Enrollment: 121
Sex: ALL
Minimum age (years): 18
Maximum age (years): 80
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Patients with medium and large joint osteoarthritis

Brief summary: This study evaluates laboratory-based method to estimate the degrees of activity of medium and large joint osteoarthritis.

Detailed description: Osteoarthritis (OA) is a chronic progressive disease, characterized by degradation of joint cartilage, synovial inflammation and joint dysfunction. This study evaluates laboratory-based method to estimate the degrees of activity of medium and large joint OA. Samples of synovial fluid (SF) from the patients with the OA (ICD-10 codes: M15, M16 and M17) will be assessed for T-cell subsets, msast cells, fibroblast-like synoviocytes (FLS) and macrophage-like synoviocytes (MLS) by flow cytometry. Subpopulations of blood T-cells involved in the inflammation will also be assayed. Standard clinical investigation will be performed and the results will be used to estimate the laboratory criteria or degrees of activity of medium and large joint OA.

Eligibility criteria: Inclusion Criteria:

* medium and large joint active osteoarthritis

Exclusion Criteria:

* refuse of patient to participate in the trial;
* acute infectious diseases;
* pregnancy/lactation;
* intercurrent severe chronic diseases;
* HIV, Hepatites B/C;
* active tuberculosis;
* alcohol use disorder/drug addiction;
* malignant neoplasms/leukemia.

Primary outcomes:
measure: The sensitivity of the proposed laboratory-based method in the diagnostics of the activity of osteoarthritis
timeFrame: 2 month
Secondary outcomes:
Other outcomes:
Locations:
city: Minsk
country: Belarus
facility: Andrei Hancharou
Study officials:
affiliation: Head of the Laboratory for Immunology and Cellular Biotechnology, The Republican Research and Practical Center for Epidemiology and Microbiology
name: Andrei Y Hancharou, Dr
role: STUDY_DIRECTOR
References:
Clinical trial NCT00729170: Milk Supplementation and Energy Balance.
Official title: Impact of Milk Supplementation on Body Composition, Bone Density and Satiety in Women Following a Weight Loss Program.
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Obesity
Osteoporosis
Keywords: Milk
Calcium
Weight loss
Bone density
Appetite
Lead sponsor: Laval University
Sponsor class: OTHER
Collaborators: name: Dairy Farmers of Canada
name: National Dairy Council
First posted: 2008-08-07
Enrollment: 41
Sex: FEMALE
Minimum age (years): 25
Maximum age (years): 50
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The aim of the project is to determine if milk supplementation during a caloric restriction program facilitates the lost of weight, improves the appetite control and attenuates the decrease of bone mineral content in low-calcium consumer women.

Detailed description: Calcium deficiency is related to a higher risk of obesity. Some studies showed a lost of weight by elevating the calcium consumption to reach the recommended level. Milk supplementation could be a good alternative to reach this objective, but its impact on weight loss and on appetite sensations has not been verified. Furthermore, losing weight leads to some negative consequences like a decrease of bone mineral content. Considering the benefits of milk on bone health, a higher intake of this food product during weight loss could represent a healthy strategy.

Eligibility criteria: Inclusion Criteria:

* Low-calcium consumer (less than 800 mg daily)
* BMI between 27 to 42 kg/m2
* Sedentary
* Healthy

Exclusion Criteria:

* In menopause
* Medications that alter the project's objectives
* Smoker
* Dietary supplement consumer
* High alcohol or caffeine consumer

Primary outcomes:
measure: Body composition (body weight, fat mass, anthropometric measurements)
timeFrame: Baseline, month 1, and month 6
Secondary outcomes:
measure: Bone density (DXA)
timeFrame: Baseline and month 6
measure: Appetite sensations
timeFrame: Baseline, month 1, and month 6
Other outcomes:
Locations:
city: Québec
country: Canada
facility: Centre de recherche de l'Hôpital Laval
state: Quebec
Study officials:
affiliation: Laval University
name: Angelo Tremblay, Ph.D.
role: PRINCIPAL_INVESTIGATOR
affiliation: Laval University
name: Denis R Joanisse, Ph.D.
role: PRINCIPAL_INVESTIGATOR
References:
citation: Gilbert JA, Joanisse DR, Chaput JP, Miegueu P, Cianflone K, Almeras N, Tremblay A. Milk supplementation facilitates appetite control in obese women during weight loss: a randomised, single-blind, placebo-controlled trial. Br J Nutr. 2011 Jan;105(1):133-43. doi: 10.1017/S0007114510003119.
Clinical trial NCT05786170: ERILs Und SNILs Unter SOC
Official title: Early Recurrent Ischemic Lesions (ERILs) and Silent Neurologic Ischemic Lesions (SNILs) in Diffusion-weighted Magnetic Resonance Imaging (DW-MRI) - a Pilot- Observational Study Under Standard of Care (SOC)
Study type: INTERVENTIONAL
Overall status: WITHDRAWN
Phase: NA
Conditions: Stroke, Acute
Lead sponsor: Medical University of Vienna
Sponsor class: OTHER
Collaborators: name: Medical University Innsbruck
First posted: 2023-03-27
Enrollment: 0
Sex: ALL
Minimum age (years): 18
Maximum age (years): 100
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: DIAGNOSTIC

Brief summary: 1. How many ERILs occur in caucasian patients with LAA stroke during 7 days on standard treatment?
2. How many SNILs occur between 7 and 30 days after acute ischemic event on standard treatment?
3. How many of during acute event diagnosed lesions (ERILs) are (still) detectable after 30 days?
4. Are there relevant risk faktors for the occurence of ERILs and SNILs (eg Diabetes or Biomarkers)?

Detailed description: In this trial, patients will be observed if they develop early recurrent ischemic lesions (= ERILs) or silent neurologic ischemic lesions (= SNILs) after acute stroke or transitoric ischemic attack (TIA) based on atherothrombosis (LAA-stroke) on standard therapy during 30 days (day 7 and day 30 after acute event) via DW-MRI (diffusion-weighted magnetic resonance imaging).

We want to investigate if diffusion-weighted imaging of silent brain infarcts occuring during standard therapy is a suitable surrogate outcome measure for interventional studies

Eligibility criteria: Inclusion Criteria:

* LAA stroke or TIA
* ERILs or SNILs detected in initialDW-MRI
* signed informed consent

Exclusion Criteria:

* planned surgical intervention
* iv Thrombolysis
* atrial fibrillation
* contra indications against DW-MRI

Primary outcomes:
measure: 1. How many ERILs occur in caucasian patients with LAA stroke during 7 days on standard treatment?
timeFrame: 7 days after acute stroke
Secondary outcomes:
measure: 2. How many SNILs occur between 7 and 30 days after acute ischemic event on standard treatment and how many of during acute event diagnosed lesions (ERILs) are (still) detectable after 30 days?
timeFrame: 30 days after acute stroke
Other outcomes:
Locations:
Study officials:
References:
Clinical trial NCT01178970: The Effects of Lower Body Resistance Training on Balance and Fall Prevention in the Elderly
Official title: The Effects of Lower Body Resistance Training on Balance and Fall Prevention in the Elderly
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Fall Prevention
Lead sponsor: University of Oklahoma
Sponsor class: OTHER
First posted: 2010-08-10
Enrollment: 25
Sex: ALL
Minimum age (years): 65
Standard ages: OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: SINGLE_GROUP

Brief summary: The aim of the study is to prevent falls related to poor lower body strength adn balance in the elderly.

Detailed description: The purpose of the study is to determine the effects of a structured lower body resistance training program on balance in an elderly population. Our hypothesis is that elderly adults will improve their balance following a structured lower body strength training program compared to those who do not engage in a lower body strength training program.

Eligibility criteria: Inclusion Criteria:

* Healthy male and female adults 65 or older with physician consent to participate

Exclusion Criteria:

* Unable to obtain physician consent to participate

Primary outcomes:
measure: Balance improvement
timeFrame: 8 weeks
Secondary outcomes:
Other outcomes:
Locations:
city: Tulsa
country: United States
facility: OU-Tulsa Family Medicine Clinic
state: Oklahoma
Study officials:
References:
Clinical trial NCT05927870: Ultrasound Guided Percutaneous Cholecystostomy.
Official title: Ultrasound Guided Percutaneous Cholecystostomy as Preoperative Step for Obstructive Gallbladder Diseases.
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Gall Bladder Disease
Lead sponsor: Assiut University
Sponsor class: OTHER
First posted: 2023-07-03
Enrollment: 50
Sex: ALL
Minimum age (years): 4
Maximum age (years): 100
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: TREATMENT

Brief summary: Surgical cholecystostomy has proven value in the management of both inflammatory and obstructive biliary tract disease

Detailed description: The etiology of biliary obstruction can be benign or malignant. Benign disease, such as calculi, strictures, or pancreatitis, can be common causes in adult patients \[5\], whereas benign strictures including posttransplant anastomotic strictures and strictures secondary to hepatic artery insufficiency, stone disease, infection, and iatrogenic causes can be seen in children \[6\]. Obstruction can also be seen in the setting of biliary tract abnormalities, such as biliary atresia in neonates and symptomatic choledochal cysts, autoimmune pancreatitis, and sclerosing cholangitis in older children \[7\]. Biliary obstruction secondary to neoplasm commonly occurs with pancreatic cancer, cholangiocarcinoma, or metastases in adult patients and biliary rhabdomyosarcoma or neuroblastoma in younger patients \[8\].

The question remains as to whether all patients undergoing PCT drainage require a definitive cholecystectomy. Previous publications have suggested that there is a reluctance to use PCT in older and comorbid patients due to concerns of potentially committing such patients to an interval surgical procedure for which they may not be suitable.

Eligibility criteria: Inclusion Criteria:

* Pyocele of the gallbladder
* Mucocele of the gallbladder
* Perforated gallbladder
* Malignant causes of gallbladder obstruction

Exclusion Criteria:

* Uncontrolled bleeding disorders

Primary outcomes:
measure: value of cholecystostomy as preoperative step in critically ill patients
timeFrame: basline
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
References:
citation: Akhan O, Akinci D, Ozmen MN. Percutaneous cholecystostomy. Eur J Radiol. 2002 Sep;43(3):229-36. doi: 10.1016/s0720-048x(02)00158-4.
Clinical trial NCT04607070: Ischemic Strokes While on NOAC - How Compliance Matters
Official title: Ischemic Strokes While on NOAC - How Compliance Matters
Study type: OBSERVATIONAL
Overall status: RECRUITING
Conditions: Stroke, Ischemic
Stroke, Acute
Stroke Syndrome
Stroke, Cardiovascular
Atherosclerosis
Ischemic Stroke
Keywords: stroke, NOAC
Lead sponsor: Chinese University of Hong Kong
Sponsor class: OTHER
First posted: 2020-10-28
Enrollment: 870
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: RETROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Patients with known AF who developed ischaemic stroke or TIA and admitted in the Prince of Wales Hospital in years 2010, 2012, 2014, 2016 and 2018 will be recruited into this study

Brief summary: This study is aimed to depict the epidemiological trend, aetiologies, clinical characteristics, treatment options of IS-NOAC in face of the rapidly increasing NOAC usage. Knowledge on this ischaemic stroke entity will define clinical characteristics, identify preventable causes and inform resource allocation on the evaluation modalities, reperfusion strategies and forecast future burden of IS-NOAC.

Detailed description: Data will be retrieved from the stroke registry of Prince of Wales Hospital which recorded all in- and out-patients with stroke or transient ischaemic attack (TIA). All consecutive adult patients with known AF who developed ischaemic stroke or TIA in 2010, 2012, 2014, 2016 and 2018 (i.e. 5 full yearly time-points) and categorize the patients according to their anticoagulation status (elaborated below) with the inclusion and exclusion criteria stated will be recruited.

All demographic data, blood results, imaging and assessment data will be retrieved from electronic patient record (CMS system) and stroke registry. All-cause mortality at 1 year will be verified via CMS system too.

Eligibility criteria: Inclusion Criteria:

1. Patients who were ethnic Chinese
2. Patients with known AF
3. Patient who suffered from ischaemic stroke

Exclusion Criteria:

1. Patient who are non-ethnic Chinese
2. Patient who suffered from haemorrhagic stroke

Primary outcomes:
measure: Compliance affects the outcomes of ischemic stroke during NOAC usage.
timeFrame: 30 Sept 2021
Secondary outcomes:
Other outcomes:
Locations:
city: Hong Kong
country: Hong Kong
facility: Chinese University of Hong Kong
Study officials:
affiliation: Chinese University of Hong Kong
name: Yiu Ming Bonaventure IP, MBChB, MRCP
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT01412970: Non-invasive Measurement of Central Hemodynamics by Electrical Impedance Tomography
Official title: Non-invasive Measurement of Central Hemodynamics and Heart-lung Interactions by Electrical Impedance Tomography
Study type: INTERVENTIONAL
Overall status: WITHDRAWN
Phase: NA
Conditions: Comparison of Availability for Prediction of Volume Responsiveness
Comparison of Limits of Agreement for Invasive and Non-invasive Measurement of Stroke Volume Variation
Keywords: hemodynamic monitoring
volume responsiveness
electrical impedance tomography
Lead sponsor: Universitätsklinikum Hamburg-Eppendorf
Sponsor class: OTHER
Collaborators: name: CSEM Centre Suisse d'Electronique et de Microtechnique SA - Recherche et Developpement
name: Oregon Health and Science University
First posted: 2011-08-09
Enrollment: 0
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: DIAGNOSTIC

Brief summary: The purpose of this study is to evaluate the ability to measure central hemodynamics and heart-lung interactions non-invasively by electrical impedance tomography and compare it to clinically established hemodynamic monitoring.

Detailed description: The purpose of this study is to evaluate the ability to measure central hemodynamics and heart-lung interactions non-invasively by electrical impedance tomography and compare it to clinically established hemodynamic monitoring.

Eligibility criteria: Inclusion Criteria:

* Age \>18 years
* Indication for advanced invasive hemodynamic monitoring due to operative procedure
* Necessity of postoperative invasive ventilation

Exclusion Criteria:

* Age \<18 years
* known affections cardiac function
* presence of cardiac arrhythmias
* contraindication for placement of central venous or femoral artery catheter

Primary outcomes:
measure: Ability to assess volume responsiveness by electrical impedance tomography
timeFrame: within 3 hrs after surgical procedure
Secondary outcomes:
measure: precision of estimation of non invasive measurement of stroke volume variation
timeFrame: within 3 hours after surgery
Other outcomes:
Locations:
city: Hamburg
country: Germany
facility: University Medical Center Hamburg-Eppendorf
Study officials:
affiliation: Universitätsklinikum Hamburg-Eppendorf
name: Daniel A Reuter, MD
role: PRINCIPAL_INVESTIGATOR
References:
citation: Maisch S, Bohm SH, Sola J, Goepfert MS, Kubitz JC, Richter HP, Ridder J, Goetz AE, Reuter DA. Heart-lung interactions measured by electrical impedance tomography. Crit Care Med. 2011 Sep;39(9):2173-6. doi: 10.1097/CCM.0b013e3182227e65.
Clinical trial NCT03107975: Effect of Human Amniotic Epithelial Cells on Children With Spastic Cerebral Palsy
Official title: Effect of Intrathecal Transplant of Human Amniotic Epithelial Cells on Children With Spastic Cerebral Palsy
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: PHASE1
Conditions: Spastic Cerebral Palsy
Lead sponsor: The Second Affiliated Hospital of Fujian Medical University
Sponsor class: OTHER
Collaborators: name: Shanghai iCELL Biotechnology Co., Ltd, Shanghai, China
First posted: 2017-04-11
Enrollment: 10
Sex: ALL
Minimum age (years): 1
Maximum age (years): 5
Standard ages: CHILD
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: TREATMENT

Brief summary: This study aimed to evaluate the therapeutic potential of human amniotic epithelial cell (hAEC) transplant in the management of children with spastic cerebral palsy.

Detailed description: Cerebral palsy is one of the most common congenital (existing at or before birth) disorders of childhood.Spastic cerebral palsy causes stiffness and movement difficulties.There is no cure for the disease now.

This study aimed to evaluate the therapeutic potential of human amniotic epithelial cell (hAEC) transplant in the management of children with spastic cerebral palsy. hAEC will be intrathecal transplanted. Functional status is determined by Gross Motor Function Measure-66 and Fine Motor Function Measure. Spasticity is evaluated by using modified Ashworth scale(MAS).

Eligibility criteria: Inclusion Criteria:

* Signed informed consent document;
* Gross Motor Function Classification System (GMFCS) levels III-V;
* Parents accepted voluntarily cell therapy for their children and followed-up.

Exclusion Criteria:

* Have a history of severe allergic;
* Serological tests such as AIDS, hepatitis B, syphilis, etc;
* Hereditary metabolic diseases of nervous system;
* Tumor or Hematological diseases.

Primary outcomes:
measure: Gross Motor Function Measure-66
timeFrame: 6 months
Secondary outcomes:
measure: Fine Motor Function Measure
timeFrame: 6 months
measure: Modified Ashworth Scale
timeFrame: 6 months
measure: Gesell Developmental Scales
timeFrame: 6 months
Other outcomes:
Locations:
city: Quanzhou
country: China
facility: The Second Affiliated Hospital of Fujian Medical University
state: Fujian
Study officials:
affiliation: The Second Affiliated Hospital of Fujian Medical University
name: Hongzhi Gao, Dr.
role: PRINCIPAL_INVESTIGATOR
References: