Clinical trial NCT05871619: Combined Application of Diode Laser and Different Remineralizing Agents on White Spot Lesions
Official title: Clinical Efficacy of Combined Application of Diode Laser and Different Remineralizing Agents on Combined Application of Diode Laser and Different Remineralizing Agents on White Spot Lesions
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: White Spot Lesion of Tooth
Keywords: white spot lesion, diode laser, vita easy shade V
Lead sponsor: Al-Azhar University
Sponsor class: OTHER
First posted: 2023-05-23
Enrollment: 45
Sex: FEMALE
Minimum age (years): 15
Maximum age (years): 40
Standard ages: CHILD
ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Intervention model description: * The first group (A1B1):15 teeth with WSL were treated with Remin Pro with laser application.
* The second group (A1B2): The contralateral 15 teeth were treated with Remin Pro without laser application.

The third group (A2B1): 15 teeth with WSL were treated with X Pur Remin with laser application.

* The fourth group (A2B2): The contralateral 15 teeth will be treated with XPur Remin without laser application.
* The fifth group (A3B1): 15 teeth with WSL were treated with 5% sodium fluoride varnish with laser application.
* The sixth group (A3B2): The contralateral 15 teeth were treated with 5% sodium fluoride without laser application
Primary purpose: TREATMENT

Brief summary: Dental caries is a very common condition, and although it has become less common, it still represents a serious public health risk. Caries symptoms range from the earliest molecular alterations in the tooth's apatite crystals to an apparent white spot lesion (WSL) or eventual cavitation. The white spot lesion looks chalky because minerals are being lost from both the surface and the underside of the enamel. A relatively simple and noninvasive caries preventive regimen in treating white spot lesions with low-level laser irradiation, either alone or with topical ﬂuoride treatment. This treatment results in reduced enamel solubility and dissolution.

Detailed description: The study was reviewed and approved by the "Ethical research committee "of the Faculty of Dental Medicine for Girls; at Al-Azhar University, Cairo, Egypt. This study was conducted on 90 teeth with white spot lesions (WSLs) detected clinically on the buccal surface of teeth. The patients with WSLs were selected randomly from the operative dentistry clinic at the Faculty of Dentistry, Girl's Branch, Al-Azhar University

After examination, the teeth will be assigned into six groups of 15 teeth with white spot lesions each according to the remineralizing material used:

* The first group (A1B1): The teeth with WSL will be treated with nano-hydroxyapatite +fluoride with laser application.
* The second group (A1B2): The contralateral teeth will be treated with nano-hydroxyapatite +fluoride without laser application.
* The third group (A2B1): The teeth with WSL will be treated with nano-hydroxyapatite + xylitol with laser application.
* The fourth group (A2B2): The contralateral teeth will be treated with nano hydroxyapatite+ xylitol without laser application.
* The fifth group (A3B1): The teeth with WSL will be treated with 5% sodium fluoride varnish with laser application.
* The sixth group (A3B2): The contralateral teeth will be treated with 5% sodium fluoride without laser application.

Eligibility criteria: Inclusion Criteria:

* The patients should be 13-40 years old.
* Patients should have good oral hygiene.
* The patients with good general health and no systemic disease.

Exclusion Criteria:

* - Presence of enamel hypoplasia or dental fluorosis.
* Presence of carious cavity.
* Patients who have a significant medical history,
* Patients who have evidence of reduced salivary flow or significant tooth wear.

Primary outcomes:
measure: Spectrophotometric color assessment:
timeFrame: from base line (application of materials) to one month
Secondary outcomes:
measure: surface area measurement
timeFrame: from base line (application of materials) to one month
Other outcomes:
Locations:
city: El Cairo
country: Egypt
facility: Al-Azhar University
Study officials:
affiliation: for Operative Dentistry Faculty of Dental Medicine for Girls Al-Azhar University
name: Wael Essam, professor
role: STUDY_DIRECTOR
References: