Clinical trial NCT05587686: Potential Impact of the Use of the Application VentilO
Official title: Frequency of Respiratory Acidosis and Alkalosis in the Emergency and Intensive Care Department of the IUCPQ-UL. Potential Impact of the Use of the Application VentilO
Study type: OBSERVATIONAL
Overall status: ACTIVE_NOT_RECRUITING
Conditions: Mechanical Ventilation Complication
Lead sponsor: Laval University
Sponsor class: OTHER
First posted: 2022-10-20
Enrollment: 100
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: RETROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Intubated patients during their stay in the IUCPQ-UL emergency or intensive care department

Brief summary: Mechanical ventilation is a vital support associated with the treatment of patients with acute respiratory failure and in other indications such as surgery under general anesthesia, coma or shock. Optimization of settings during mechanical ventilation and implementation of protective ventilation help to avoid ventilation-induced injury, ensure adequate oxygenation and maintain adequate carbon dioxide concentration to avoid respiratory acidosis or alkalosis.

Similarly, there is also no clear recommendation, to our knowledge, for the initial setting of the respiratory rate. Therefore, initial settings are not always adequate and in the literature the frequency of respiratory acidosis is very high, reaching about half of the patients receiving mechanical ventilation.

VentilO, is an application that is available on smart phones. This educational application provides clinicians with initial settings and optimization of these settings based on gender, height, weight, body temperature and patient type. The algorithm used is based on published data regarding ventilatory requirements in different populations and the anatomical and instrumental dead space of patients.

The purpose of our study is to:

1. Assess whether ventilatory settings after intubation are appropriate.
2. To compare the ventilatory adjustments made by clinicians with those proposed by the VentilO appalication.


Eligibility criteria: Inclusion Criteria:

* Adults (\> or = 18 years old)
* New endotracheal intubation

Exclusion Criteria:

* Absence of arterial (or capillary) gas within two hours of intubation
* Absence of patient sizes available throughout the medical record

Primary outcomes:
measure: acid-base abnormalities on arterial (or capillary) blood gases
timeFrame: on the first result available of arterial(or capillary) blood gases after intubation; 2 hours maximum post intubation
measure: Improvement acid-base abnormalities with the VentilO application
timeFrame: on the first result available of arterial(or capillary) blood gases after intubation; 2 hours maximum post intubation
measure: Impairement acid-base abnormalities with the VentilO application
timeFrame: on the first result available of arterial(or capillary) blood gases after intubation; 2 hours maximum post intubation
Secondary outcomes:
measure: Occurence of optimal arterial (or capillary) blood gases result
timeFrame: on the first result available of arterial(or capillary) blood gases after intubation; 2 hours maximum post intubation
measure: Severity of unbalance of arterial (or capillary) blood gases result
timeFrame: on the first result available of arterial(or capillary) blood gases after intubation; 2 hours maximum post intubation
measure: hemodynamic instabilities
timeFrame: Between Hour0 to Hour1 after intubation
measure: ICU length of stay
timeFrame: up to 90 days. ICU stay - ICU admission through ICU discharge or until death if occured
measure: Hospital length of stay
timeFrame: up to 90 days. ICU stay - Emergency department admission through hospital discharge or until death if occured
measure: ICU mortality
timeFrame: up to 90 days. ICU admission through until death if occured
Other outcomes:
Locations:
city: Quebec
country: Canada
facility: Institut Universitaire de Cardiologie et de Pneumologie de Québec
Study officials:
References: