Clinical trial NCT02013596: Transcutaneous Electrical Acupoint Stimulation(TEAS) for Hepatic and Renal Dysfunction After Pneumoperitoneum
Official title: Effect of Transcutaneous Electrical Acupoint Stimulation(TEAS) on the Hepatic and Renal Function Impaired by Pneumoperitoneum: a Prospective, Randomized Controlled Trial
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Hepatic Dysfunction Transient
Renal Function Disorder
Keywords: hepatic dysfunction
renal dysfunction
pneumoperitoneum
Transcutaneous electric stimulation
Lead sponsor: Air Force Military Medical University, China
Sponsor class: OTHER
First posted: 2013-12-17
Enrollment: 168
Sex: ALL
Minimum age (years): 18
Maximum age (years): 60
Standard ages: ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The purpose of this study is to compare the effect of TEAS pretreatment and treatment on hepatic and renal dysfunction induced by pneumoperitoneum in patients undergoing laparoscopic surgeries.

Detailed description: Patients were randomly assigned to three groups, control group and two intervention groups, receiving TEAS before and after general anesthesia induction respectively. TEAS was given through electrodes attached to acupoints. The time for TEAS was 30min. Venous blood samples were collected before and 20min after pneumoperitoneum. Hepatic and renal function index including AST, ALT, ALP, BUN, Cr were measured.

Eligibility criteria: Inclusion Criteria:

* Age\>18yrs,\<60yrs；
* ASA 1-2；
* Scheduled for laparoscopic surgery under general anesthesia；
* Informed consented

Exclusion Criteria:

* Patients with hepatic or renal dysfunction；
* Patients with severe hypertension or cardiac dysfunction；
* Patients with severe pulmonary disease；
* Patients with hemoglobin\<100g/L

Primary outcomes:
measure: Incidence of renal or hepatic dysfunction
timeFrame: 20min after pneumoperitoneum
Secondary outcomes:
measure: Change of hepatic function
timeFrame: 20min after pneumoperitoneum
measure: Change of renal function
timeFrame: 20min after pneumoperitoneum
Other outcomes:
Locations:
city: Xi'an
country: China
facility: Xijing Hospital, Fourth Military Medical University
state: Shaanxi
Study officials:
affiliation: Air Force Military Medical University, China
name: zhihong Lu, MD
role: PRINCIPAL_INVESTIGATOR
References:
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