Clinical trial NCT06264141: Evaluation of Nitric Oxide Nasal Spray (NONS) for Treatment of Recurrent Acute Rhinosinusitis
Official title: Multicenter, Randomized, Double-blinded, Placebo-controlled, Phase 2 Clinical Efficacy Study Evaluating Nitric Oxide Nasal Spray (NONS) Compared to Saline Nasal Spray as an Early Treatment for Recurrent Acute Rhinosinusitis (RARS)
Study type: INTERVENTIONAL
Overall status: ACTIVE_NOT_RECRUITING
Phase: PHASE2
Conditions: Recurrent Acute Rhinosinusitis
Keywords: Sinusitis
Nitric oxide
RARS
NONS
Nasal spray
Rhinosinusitis
Recurrent
Acute
Lead sponsor: Sanotize Research and Development corp.
Sponsor class: INDUSTRY
First posted: 2024-02-16
Enrollment: 162
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Intervention model description: A two-week therapy of NONS vs Placebo (saline nasal spray) initiated immediately after the onset of a new RARS episode to assess the acceleration to clinical success (cured/much-improved symptoms), lack of use of INCS (Day 5, or thereafter) and rescue oral antibiotics (ATBs) (Day 8, or thereafter) after initiation of nitric oxide-releasing solution (NORS) platform therapy.
Primary purpose: TREATMENT

Brief summary: A two-week therapy of nitric oxide nasal spray (NONS) vs Placebo (saline nasal spray) initiated immediately after the onset of a new Recurrent Acute Rhinosinusitis (RARS) episode to assess the acceleration to clinical success (cured/much improved symptoms), lack of use of intranasal corticosteroids (INCS) (Day 5, or thereafter) and rescue oral antibiotics (ATBs) (Day 8, or thereafter) after initiation of nitric oxide releasing solution (NORS) platform therapy.

Detailed description: Study Design:

This is a multicenter, randomized, double-blind placebo-controlled, two-arm, parallel-group, phase 2 clinical trial to determine the efficacy and safety of NONS to treat recurrent acute (bacterial) rhinosinusitis (RARS).

Nitric oxide-releasing solution (NORS) therapy administered as NONS, has the potential to shorten RARS episodes and may reduce the concomitant use of INCS, oral non-steroidal anti-inflammatory drugs (NSAIDS) and oral ATBs used to manage this condition. Suitable candidates will be randomized to a 2-week course of nitric oxide nasal spray (NONS) compared to saline nasal spray (1:1 ratio, administered as five doses daily). RARS symptoms efficacy response will be measured twice daily, after initiation of study medication (Day 1 to Day 15), then once daily to the end of the study (Day 16 to Day 29). The goal of NONS therapy is to accelerate the time to achieve RARS symptoms resolution, defined as a clinical success (cured or much improved sinusitis symptoms; primary endpoint assessment at Day 8), minimize the use of INCS and the avoidance of rescue oral ATBs (both secondary endpoints) over the study period (Day 1 to Day 29). Participants will be enrolled between RARS episodes while asymptomatic, and on study for up to 4 months or until their next recurrence of RARS at which time study procedures and medication begin.

Adults (18 years or older) presenting with a history of mild to severe RARS symptoms (nasal obstruction (congestion), purulent nasal discharge, postnasal drip, headache, facial pain), signs (such as facial swelling), and other nonspecific signs/symptoms of fever and malaise are eligible.

The primary endpoint is is the time to sinus symptoms resolution, i.e., being cured or much improved (participant reported clinical success) after 7 days of therapy,

Eligibility criteria: Inclusion Criteria:

1. At least aged 18 years old at the time of consent (19 years depending on the age of majority in the Canadian province/territory).
2. History of recurrent acute bacterial sinusitis (ABS) with at least three episodes in the previous 12 months with at least two episodes requiring ATB therapy (with symptom-free periods between infections).
3. History of at least two moderately severe symptoms of acute rhinosinusitis (anterior (nasal) and posterior (postnasal drip) secretions, nasal obstruction (congestion), headache or facial pain/pressure during a typical RARS episode.
4. If female, be surgically sterile or post-menopausal (no menses for at least 12 months), or if of childbearing potential, must be using an acceptable method of contraception such as a combination estrogen/progestin hormonal contraceptive (oral or injected) for at least 1 month prior to Screening, or such items as an intrauterine device (IUD), intrauterine system (IUS), transdermal hormonal implant, vaginal hormonal ring, or 2 forms of the following: diaphragm, cervical cap, patch, condom, spermicide, or sponge. Total abstinence is permitted. Must agree to agree continue using contraception for the duration of the study medication treatment.
5. If male, be surgically sterile, or agree to use appropriate contraception (latex condom with spermicide) when engaging in sexual activity and agree to not donate sperm for the duration of the study medication treatment.
6. Be reasonable stable health (i.e., diagnosed chronic illnesses that are not deemed stable by the participant's primary care physician), or in the opinion of the Investigator, based on medical history (i.e., absence of any clinically relevant abnormality) during Screening.
7. Be able to understand and provide written, informed consent.
8. Must be able to attend on-site and virtual study visits.

Exclusion Criteria:

1. Complicated RARS (orbital or intracranial involvement).
2. Symptoms attributed to sinus disease for longer than 4 weeks.
3. RARS with multiple courses of antimicrobial therapy failures (in previous 2 years, 3 or more episodes treated with 2 or more ATBs).
4. Disease history consistent with severe allergic or seasonal rhinitis (requiring oral cortico-steroids to manage intractable nasal symptoms).
5. Isolated frontal and sphenoidal clinical disease (given the different pathophysiology and etiologic pathogens).
6. History of nasal polyposis.
7. History of abnormal sinus pathology.
8. Previous sinus surgery.
9. Participants with cystic fibrosis.
10. Recurrent moderate epistaxis.
11. Participants with chronic obstructive pulmonary disease (COPD).
12. Participants with severe asthma (per European Respiratory Society (ERS)/American Thoracic Society (ATS) 2014).
13. Immunocompromised participants or participants with other medical conditions that may affect interpretation of the effect of trial drugs.
14. Allergic to any of the trial drugs.
15. Females who are breastfeeding, pregnant, or attempting to become pregnant.
16. Participants who have conditions that participation is not in their best interest.
17. Participants whose participation in the study, in the opinion of the Investigator, have a condition which would interfere with their ability to adhere to the protocol (e.g., participants whom are mentally or neurologically disabled and whom are considered not fit to their participation in the study), interfere with the assessment of the investigational product, or compromise the safety of the participant or the quality of the data.
18. Participants who are unable to sign the informed consent.

Primary outcomes:
measure: Primary endpoint is the time to sinus symptoms resolution
timeFrame: 8 days
Secondary outcomes:
measure: Time (days) to full recovery from sinusitis (participant reported)
timeFrame: 29 days
measure: Time (days) to sinus symptoms resolution, i.e., being cured or much improved (participant reported clinical success)
timeFrame: 29 days
measure: Time (days) to the initiation of rescue oral ATB(s), i.e., treatment failure i.e., treatment failure
timeFrame: 29 days
measure: Time (days) to initiation of INCS
timeFrame: 29 days
measure: Proportion of participants requiring INCS
timeFrame: Day 5, 8, 15 & 29
measure: Proportion of participants requiring rescue oral ATBs
timeFrame: Day 5, 8, 15 & 29
measure: Proportion of participants recovered from sinusitis
timeFrame: Day 5, 8, 15 & 29
measure: Proportion of participants with rapidly worsening symptoms requiring the use of INCS and oral ATBs
timeFrame: 29 days
measure: Proportion of participants achieving at least a 9-point improvement change from baseline in Sinonasal Outcome Test (SNOT)-22
timeFrame: Day 8 & 15
measure: Tolerability and safety of NONS
timeFrame: 29 days
measure: Proportion of participants with clinically significant changes from baseline in vital signs
timeFrame: 29 days
measure: Proportion of participants with clinically significant changes from baseline in laboratory parameters
timeFrame: 29 days
measure: Number of participants with clinically significant changes from Baseline in physical examinations
timeFrame: 29 days
Other outcomes:
measure: Number of ATB courses required as a rescue treatment
timeFrame: 29 days
measure: Time (days) to the initiation of NSAIDs
timeFrame: 29 days
measure: Proportion of participants requiring NSAIDs
timeFrame: 29 days
measure: Time (days) to each symptom being cured or much improved
timeFrame: 29 days
measure: Proportion of participants being cured or much improved for each symptom
timeFrame: Day 8, 15 & 29
measure: Proportion of participants achieving at least a 50% reduction in sinusitis symptoms (by MRSS)
timeFrame: Day 5, 8, 15 & 29
Locations:
city: Kelowna
country: Canada
facility: Okanegan Clinical Trials
state: British Columbia
city: Richmond
country: Canada
facility: Richmond Clinical Trials (Okanagan Clinical Trials Satelite Site)
state: British Columbia
city: Mississauga
country: Canada
facility: Cliantha Research
state: Ontario
city: Scarborough
country: Canada
facility: Clinical Research of Ontario
state: Ontario
city: Chicoutimi
country: Canada
facility: Intermed Groupe Santé
state: Quebec
city: Québec City
country: Canada
facility: Alpha Recherche Clinique LeBourneuf
state: Quebec
city: Québec City
country: Canada
facility: Alpha Recherche Clinique Val-Belair
state: Quebec
Study officials:
affiliation: Sanotize Research and Development corp.
name: Keith Moore, PharmD
role: STUDY_DIRECTOR
References: