Clinical trial NCT03732066: Web basEd soCial Media tecHnology to Improvement in Adherence to Dual anTiplatelet Therapy Following Drug-Eluting Stent Implantation
Official title: Web basEd soCial Media tecHnology to Improvement in Adherence to Dual anTiplatelet Therapy Following Drug-Eluting Stent Implantation (WeChat), a Randomized Controlled Branch on Antiplatelet of RESCIND Study
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Coronary Disease
Keywords: Dual antiplatelet therapy
Mobile health
Discontinuation rate
Drug-eluting stent implantation
Randomized controlled trial
Lead sponsor: Guangdong Provincial People's Hospital
Sponsor class: OTHER
Collaborators: name: Dongguan People's Hospital
name: First People's Hospital, Shunde China
name: Guangzhou Panyu Central Hospital
name: Maoming People's Hospital
First posted: 2018-11-06
Enrollment: 760
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Intervention model description: Randomization will be performed using a centralized, computerized randomization program in a uniform 1:1 allocation ratio.
Primary purpose: HEALTH_SERVICES_RESEARCH

Brief summary: Few studies have attempt to improve DAPT adherence through social media. The investigators will explore the prevalence of DAPT discontinuation and prove the hypothesis that using social media will improve DAPT adherence among patients requiring DAPT following DES implantation.

Detailed description: Dual antiplatelet therapy (DAPT) is frequently discontinued after drug-eluting stent (DES) implantation, which could lead to many major adverse cardiovascular events (MACEs). Social media have been proven effective in improving lifestyles and blood pressures control, but few studies have attempt to improve DAPT adherence through social media.Therefore, eligible patients will be enrolled through scanning QR code and randomized in a 1:1 ratio to an intervention group or control group with 12 months of follow-up.The investigators will find out the prevalence of DAPT discontinuation and prove the hypothesis that using social media will improve DAPT adherence among patients requiring DAPT following DES implantation..

Eligibility criteria: Inclusion Criteria:

* aged ≥18 years
* diagnosed CHD and underwent DES implantation
* provide written informed consent

Exclusion Criteria:

* pregnancy
* malignant tumor or end-stage disease with a life expectancy of \<1 year;
* refusal to use social media
* refusal to provide written informed consent for this study

Primary outcomes:
measure: Rate of Discontinuation of Dual Antiplatelet Drug
timeFrame: 1 year
Secondary outcomes:
measure: Medication Adherence
timeFrame: 1 year
measure: Number of Participants with Major Adverse Cardiovascular Events
timeFrame: 1 year
Other outcomes:
Locations:
city: Guangzhou
country: China
facility: Guangdong General Hospital
state: Guangdong
Study officials:
affiliation: Guangdong Cardiovascular Institute,Guangdong General Hospital
name: Yong Liu, MD
role: STUDY_CHAIR
References:
citation: Sun GL, Lei L, Liu L, Liu J, He Y, Guo Z, Dai X, He L, Chen SQ, Liang Y, Ye J, Hu Y, Chen G, Chen JY, Liu Y. Rationale and design of the Web-basEd soCial media tecHnology to improvement in Adherence to dual anTiplatelet Therapy following Drug-Eluting Stent Implantation (WECHAT): protocol for a randomised controlled study. BMJ Open. 2020 Jan 7;10(1):e033017. doi: 10.1136/bmjopen-2019-033017.