Clinical trial NCT00181259: Magnetic Resonance Spectroscopy Studies of Cardiac Muscle Metabolism
Official title: In Vivo Cardiac Metabolism in Normal, Ischemic, and Cardiomyopathic Patients During Rest and Stress
Study type: OBSERVATIONAL
Overall status: RECRUITING
Conditions: Heart Failure, Congestive
Lead sponsor: Johns Hopkins University
Sponsor class: OTHER
Collaborators: name: National Heart, Lung, and Blood Institute (NHLBI)
First posted: 2005-09-16
Enrollment: 500
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: OTHER
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: Patients with coronary artery disease, dilated cardiomyopathy, or left ventricular hypertrophy

Brief summary: The metabolism of the heart provides the chemical energy needed to fuel ongoing normal heart contraction. Magnetic resonance spectroscopy is a technique used in a MRI scanner that can be used to measure and study heart metabolism directly but without blood sampling or obtaining tissue biopsies. One of the hypotheses this study aims to investigate is whether energy metabolism is reduced in heart failure and whether that contributes to the poor heart function.

Detailed description: This study uses magnetic resonance (MR) spectroscopy to study heart metabolism and function in normal subjects and patients with left ventricular hypertrophy, dilated cardiomyopathy, and those with coronary artery disease.

Eligibility criteria: Inclusion Criteria:

* age \> 18 years
* Healthy subjects: no history of heart disease
* Dilated cardiomyopathy: history of heart failure, ejection fraction (EF) \<40%
* Left ventricular hypertrophy: wall thickness \>1.2cm
* Coronary artery disease: \>50% coronary lesion or positive stress test

Exclusion Criteria:

* contraindication to MRI

Primary outcomes:
measure: Phosphocreatine/adenosine triphosphate (PCr/ATP) and creatine kinase (CK) flux
timeFrame: At time of magnetic resonance spectroscopy (MRS)
Secondary outcomes:
measure: Phosphocreatine (PCr)
timeFrame: At time of MRS
measure: ATP
timeFrame: At time of MRS
measure: [Cr] or total creatine (CR), or CR/water ratio
timeFrame: At time of MRS
measure: Sodium (NA)
timeFrame: At time of MRS
measure: ATP flux
timeFrame: At time of MRS
measure: 31P distribution or metabolite map
timeFrame: At time of MRS
measure: 23Na distribution or metabolite map
timeFrame: At time of MRS
measure: CR distribution or metabolite map
timeFrame: At time of MRS
Other outcomes:
Locations:
city: Baltimore
country: United States
facility: Johns Hopkins Medical Institutions
state: Maryland
Study officials:
affiliation: Johns Hopkins University
name: Robert G. Weiss, MD
role: PRINCIPAL_INVESTIGATOR
References:
citation: Keceli G, Gupta A, Sourdon J, Gabr R, Schar M, Dey S, Tocchetti CG, Stuber A, Agrimi J, Zhang Y, Leppo M, Steenbergen C, Lai S, Yanek LR, O'Rourke B, Gerstenblith G, Bottomley PA, Wang Y, Paolocci N, Weiss RG. Mitochondrial Creatine Kinase Attenuates Pathologic Remodeling in Heart Failure. Circ Res. 2022 Mar 4;130(5):741-759. doi: 10.1161/CIRCRESAHA.121.319648. Epub 2022 Feb 3.
citation: Solaiyappan M, Weiss RG, Bottomley PA. Neural-network classification of cardiac disease from 31P cardiovascular magnetic resonance spectroscopy measures of creatine kinase energy metabolism. J Cardiovasc Magn Reson. 2019 Aug 12;21(1):49. doi: 10.1186/s12968-019-0560-5.
citation: Gabr RE, El-Sharkawy AM, Schar M, Panjrath GS, Gerstenblith G, Weiss RG, Bottomley PA. Cardiac work is related to creatine kinase energy supply in human heart failure: a cardiovascular magnetic resonance spectroscopy study. J Cardiovasc Magn Reson. 2018 Dec 10;20(1):81. doi: 10.1186/s12968-018-0491-6.