Clinical trial NCT05065606: Descriptive Analysis of Dual-energy Computed Tomography Exams of Adult Patients With Gout
Official title: Descriptive Analysis of Soft-tissue Urate Deposits, and Bone and Joint Destruction in Dual-energy Computed Tomography Exams of Adult Patients With Gout
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Gout
Lead sponsor: Assistance Publique - Hôpitaux de Paris
Sponsor class: OTHER
Collaborators: name: Canon Medical Systems, USA
First posted: 2021-10-04
Enrollment: 150
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: CASE_ONLY
Time perspective: RETROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Retrospective analysis of dual-energy CT exams performed in routine care in patients with gout according to ACR criteria, patients included between end of year 2016 and end of year 2021 (retrospective and prospective inclusion, retrospective analysis)

Brief summary: The main objective is to describe urate deposits (especially in terms of distribution and volume) in soft tissues and bone, and joint erosions and destruction, in adult patients with gout.

Detailed description: Gout is the result of hyperuricemia, itself a consequence of a disorder of purine metabolism. This hypuricemia can lead to the deposition of sodium urate crystals in the soft tissues. It is the deposition of sodium urate crystals in and near the joints that causes an intense local inflammatory reaction with episodes of acute joint pain, swelling and functional disability. In the long term, uratic concretions in the soft tissues (tophus) occur, the joints are destroyed (uratic arthropathies), the kidneys also (gouty nephropathy).

Dual-energy CT (Computed Tomography) is a relatively recent technique that allows the identification of certain materials through the analysis of the difference in attenuation of the material exposed to two different X-ray spectra. This technique identifies the crystalline component of tophus.

Eligibility criteria: Inclusion Criteria:

* Age greater than or equal to 18 years old;
* Patient with a gout according to ACR (American College of Rheumatology) criteria;
* Affiliated with a social security scheme.
* Dual-energy scanner examinations stored in the PACS at Lariboisière Hospital

Exclusion Criteria:

* Pregnant or breastfeeding woman.

Primary outcomes:
measure: Soft tissue tophus description
timeFrame: The day of the CT (computed tomography) examination
measure: Distribution of urate deposits
timeFrame: The day of the CT examination
measure: Descriptive analysis of joint erosions and destruction
timeFrame: The day of the CT examination
Secondary outcomes:
measure: Correlation of the descriptive parameters on dual-energy CT with clinical data
timeFrame: The day of the CT examination
measure: Variations in tophaceous burden
timeFrame: The day of the CT examination
measure: Link between tophus and erosions
timeFrame: The day of the CT examination
measure: Reproducibility of a scoring system
timeFrame: The day of the CT examination
measure: Bone mineral density
timeFrame: The day of the CT examination
measure: Tophus texture
timeFrame: The day of the CT examination
Other outcomes:
Locations:
city: Paris
country: France
facility: Hôpital Lariboisière - Service d'Imagerie OstéoArticulaire, Viscérale et Vasculaire
city: Paris
country: France
facility: Hôpital Lariboisière - Service de Rhumatologie
city: Paris
country: France
facility: Hôpital Bichat - Service de Rhumatologie
Study officials:
affiliation: APHP Lariboisière - Imagerie OstéoArticulaire,Viscérale
name: Valérie BOUSSON, PUPH
role: STUDY_DIRECTOR
affiliation: APHP Lariboisière - Imagerie OstéoArticulaire,Viscérale
name: Valérie BOUSSON, PUPH
role: PRINCIPAL_INVESTIGATOR
References: