louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT06318065: Surgical Resection Outcomes in Patients With Brain Metastasis
Official title: Prognostic Factors Impacting Surgical Resection Outcomes in Patients With Brain
Study type: OBSERVATIONAL
Overall status: RECRUITING
Conditions: Brain Metastases
Lead sponsor: National Cheng-Kung University Hospital
Sponsor class: OTHER
First posted: 2024-03-19
Enrollment: 100
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: RETROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Patients newly diagnosed with BM due to various primary cancers who underwent surgery at our institution

Brief summary: While many studies have investigated the prognostic factors for patients undergoing surgical resection for primary brain tumors, decision-making for patients with brain metastasis (BM) is more complex because of their higher burden of comorbidities compared to those with primary brain tumors. In addition, although various prognostic indicators have been identified to predict prognosis in several types of cancer, such as the neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), prognostic nutritional index (PNI), and systemic immune-inflammation index (SII), limited studies have yet determined which group of patients would yield beater survival outcome after surgical resection for BM. This study aimed to investigate the impact of patient and perioperative characteristics and prognostic indicators on survival outcome of patients undergoing surgical resection of BM.


Eligibility criteria: Inclusion Criteria:

1. patients with Clinical diagnosis of brain metastasis
2. patients who underwent craniotomy surgery for brain metastasis

Exclusion Criteria:

1. patients with insufficient data for associated factors
2. patients who underwent stereotactic biopsy for brain metastasis
3. patients who did not undergo craniotomy surgery for brain metastasis

Primary outcomes:
measure: survival outcome of patients undergoing surgery for brain metastasis
timeFrame: From date of surgery until the date of death from any cause, whichever came first, assessed up to 100 months
measure: Functional outcome of patients undergoing surgery for brain metastasis
timeFrame: from date of surgery until 6 months after surgery ordate of death from any cause, whichever came first
Secondary outcomes:
Other outcomes:
Locations:
city: Tainan
country: Taiwan
facility: Jung-Shun Lee
state: None Selected
Study officials:
affiliation: National Cheng Kung Univsersity Hospital
name: Jung-Shun Lee, M.D.
role: STUDY_CHAIR
References:
Clinical trial NCT05679765: Efficacy of GONB in Patients of Migraine
Official title: Analgesic Efficacy of Ultrasound-guided Greater Occipital Nerve Block in Patients of Chronic Migraine
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE4
Conditions: Chronic Migraine
Headache
Lead sponsor: Pain Medicine Department
Sponsor class: OTHER
First posted: 2023-01-11
Enrollment: 50
Sex: ALL
Minimum age (years): 18
Maximum age (years): 60
Standard ages: ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The study was carried to determine the analgesic efficacy of greater occipital nerve block in patients of migraine. It was a randomised controlled which took place from april 2022 - october 2022. Fifty patients suffering from migraine were included in the study. Patients in Group G were given greater occipital nerve block (GONB) with lignocaine and dexamethasone under ultrasound guidance while those in Group S were given saline 0.9% as placebo. Pain score using Numeric Rating Scale and number of headache days was assessed at four,eight and twelve weeks after the procedure as a primary outcome. Total headache days were recorded as a secondary outcome.


Eligibility criteria: Inclusion Criteria:

* Patients between 18 to 60 years
* diagnosed case of migraine

Exclusion Criteria:

* Patients with known allergies to local anaesthetics
* pregnancy
* history of cranial or cervical surgery
* head injury
* headaches secondary to medication overuse
* patients with uncontrolled systemic disease like blood pressure, diabetes mellitus
* hypo or hyperthyroidism
* patient who had already received GONB or botulinum toxin type A therapy within last 6 months
* major psychiatric disorder
* history of chronic pain syndromes

Primary outcomes:
measure: Analgesic efficacy
timeFrame: 12 weeks
Secondary outcomes:
measure: Headache days
timeFrame: 12 weeks
Other outcomes:
Locations:
city: Lahore
country: Pakistan
facility: Pain Medicine Department
Study officials:
affiliation: Pain Medicine Department
name: Moazzam Ali
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT03261765: Effect of Multiple Repeat Cesarean Sections on Intra-abdominal Adhesions
Official title: Effect of Multiple Repeat Cesarean Sections on Intra-abdominal Adhesions
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Cesarean Section Complications
Lead sponsor: Assiut University
Sponsor class: OTHER
First posted: 2017-08-25
Enrollment: 160
Sex: FEMALE
Minimum age (years): 18
Maximum age (years): 50
Standard ages: ADULT
Accepts healthy volunteers: no
Observational model: OTHER
Time perspective: CROSS_SECTIONAL
Sampling method: PROBABILITY_SAMPLE
Study population: All women with repeated cesarean section

Brief summary: The rate of cesarean section deliveries has increased dramatically worldwide in the last decades. While the cesarean birth rate was 4.5% in the USA in 1965, it was 31.8% according to 2007 data and is thought to be over 50% at present. The reasons for this include advanced age of primigravida, a wide range of indications, patient requests, the frequency of women with previous cesareans, women's rejections to offers of sterilization, and the common usage of assisted reproductive techniques


Eligibility criteria: Inclusion Criteria:

1. Women with at least previous one cesarean section.
2. Women accepted to participate in the study.

Exclusion Criteria:

1. Previous abdominopelvic surgery other than cesarean section.
2. History of Pelvic inflammatory disease.
3. Women refuse to participate in the study.
4. Intrauterine fetal death

Primary outcomes:
measure: Rate of abdominal adhesions
timeFrame: 30 minutes
Secondary outcomes:
Other outcomes:
Locations:
city: Assiut
country: Egypt
facility: Ahmed Abbas
state: Cairo
Study officials:
References:
Clinical trial NCT04066166: Accuracy of Rib Palpation for Dry Needling of Deep Periscapular Musculature, Measured With Ultrasound
Official title: Accuracy of Rib Palpation for Dry Needling of Deep Periscapular Musculature, Measured With Ultrasound
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Trigger Point Pain, Myofascial
Lead sponsor: University of Utah
Sponsor class: OTHER
First posted: 2019-08-26
Enrollment: 100
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: COHORT
Time perspective: CROSS_SECTIONAL
Sampling method: NON_PROBABILITY_SAMPLE
Study population: All healthy participants

Brief summary: Ultrasound was used to identify the location of a rib. This was compared to a practitioner's ability to palpate the area.

Detailed description: Ultrasound was used to identify the location of a rib. This was compared to a practitioner's ability to palpate the area. The purpose of this study is to identify if practitioners are as accurate as they think they are in identifying ribs. This is important, as mis-identifying a rib may put patients at risk for inadvertent needle entry into the lung.

Eligibility criteria: Inclusion Criteria:

* Anyone with ribs

Exclusion Criteria:

* No children

Primary outcomes:
measure: Accuracy
timeFrame: 1 year
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
affiliation: UNIVERSITY OF UTAH ORTHOPAEDICS CENTER
name: Daniel Cushman
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT06235866: Risk Identification of Long-term Complications
Official title: Risk Identification of Long-term Complications in the Recover Patients With Severe COVID-19
Study type: OBSERVATIONAL
Overall status: ENROLLING_BY_INVITATION
Conditions: Severe COVID-19
Keywords: COVID-19 Pneumonia
Long-term complications
Lung function
Lead sponsor: Wuhan Central Hospital
Sponsor class: OTHER
First posted: 2024-02-01
Enrollment: 500
Sex: ALL
Minimum age (years): 18
Maximum age (years): 80
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: CASE_ONLY
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Patients diagnosed with severe COVID-19 in our hospital from December 8, 2022 to January 31, 2023 were enrolled

Brief summary: The investigators retrospectively analyze the clinical characteristics of severe COVID-19 in our hospital, and then establish a prediction model for long-term complications in patients with severe COVID-19, and strengthen follow-up to improve the prognosis of patients.

Detailed description: At present, there is a lack of prediction models for the long-term complications of severe COVID-19. Therefore, the investigators used the hospital big data platform to retrospectively analyze the clinical characteristics of severe COVID-19 in our hospital, and conducted cohort follow-up of the changes in lung function including FEV1, FVC，FEV1% and DLCO, etc and and high-resolution CT of patients after discharge. COX model and other statistical methods were used to establish a prediction model for long-term complications of severe COVID-19, and early identification and intervention, strengthen follow-up, and improve the prognosis of patients.

Eligibility criteria: Inclusion Criteria:

The patient met the diagnostic criteria for severe COVID-19

Exclusion Criteria:

* Pregnant women Patients who died of COVID-19 Patients younger than 18 years of age without pulmonary CT

Primary outcomes:
measure: Lung function
timeFrame: 1 year
measure: Imaging of the lung
timeFrame: 1 year
Secondary outcomes:
Other outcomes:
Locations:
city: Wuhan
country: China
facility: Follow-up of patients with severe COVID-19
Study officials:
References:
Clinical trial NCT04005066: A Phase IV Study of Elunate® (Fruquintinib) in Chinese Patients
Official title: A Post-Marketing Clinical Study to Evaluate the Safety of Elunate® (Fruquintinib Capsules) in Chinese Patients.
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Patient Safety
Lead sponsor: Hutchmed
Sponsor class: INDUSTRY
First posted: 2019-07-02
Enrollment: 3005
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Advanced solid tumor patients treated with Elunate®( fruquintinib) in Chinese real world practice

Brief summary: A phase IV study to characterize safety of Elunate® (Fruquintinib) in Chinese patients

Detailed description: This study is a prospective, open-label, multi-center, study design to obtain the safety information of participant after medication. The follow-up time points for each participant include first time signing the informed consent form,1 month after signing the informed consent form, 6 months after signing the informed consent form or 30 days after the last dose (whichever occurs first).

Eligibility criteria: Inclusion Criteria:

* Currently using Elunate®(Fruquintinib) or will use Elunate®(Fruquintinib) within a week;
* Provision of informed consent by the patient.

Exclusion Criteria:

• Unsuitable for the study according to investigator's judgement.

Primary outcomes:
measure: Incidence of AEs
timeFrame: from the first administration of fruquintinib up to 6 months
measure: Incidence of ADRs
timeFrame: from the first administration of fruquintinib up to 6 months
measure: Incidence of SAEs
timeFrame: from the first administration of fruquintinib up to 6 months
measure: Incidence of AESI
timeFrame: from the first administration of fruquintinib up to 6 months
Secondary outcomes:
Other outcomes:
Locations:
city: Shanghai
country: China
facility: Shanghai Dongfang Hospital
Study officials:
affiliation: Hutchmed
name: Mandy Xue
role: STUDY_DIRECTOR
References:
Clinical trial NCT06996366: Reducing Racial and Ethnic Disparities in Medicare Annual Wellness Visit Uptake
Official title: Reducing Racial and Ethnic Disparities in Medicare Annual Wellness Visit Uptake
Study type: INTERVENTIONAL
Overall status: ACTIVE_NOT_RECRUITING
Phase: NA
Conditions: Annual Wellness Visit
Lead sponsor: Northwestern University
Sponsor class: OTHER
Collaborators: name: National Institute on Aging (NIA)
First posted: 2025-05-30
Enrollment: 174
Sex: ALL
Minimum age (years): 66
Standard ages: OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: HEALTH_SERVICES_RESEARCH

Brief summary: The goal of this randomized pilot study is to learn the impact of a primary care outreach intervention on the proportion of patients with Medicare insurance who are up-to-date on Medicare Annual Wellness Visit completion. At two clinics, researchers will randomize clinicians (and their associated, eligible patients) to early or delayed outreach.


Eligibility criteria: Inclusion Criteria:

* ≥1 in-person primary care visit during 18-month lookback period AND
* Medicare or Medicare Advantage insurance AND
* ≥1 risk factor shown to be associated with being overdue for Medicare Annual Wellness Visits (identified in preparatory analysis prior to pilot trial): Black/African American race or Latino/Hispanic ethnicity OR Not up-to-date for social needs screening OR Positive social need in past 18 months OR Medicaid insurance OR No use of scheduling features within patient portal in past 18 months
* Preferred language English AND
* Attributed primary care clinic is 1 of the participating clinics in the pilot trial AND
* No AWV completion (CPT G0402, G0438, G0439, G0468) during 10-month lookback period AND
* No appointment scheduled for upcoming AWV

Exclusion Criteria:

* Patients will be excluded if they are receiving palliative care or if their clinician feels that outreach for preventive care is inappropriate.

Primary outcomes:
measure: Completion of Annual Wellness Visit
timeFrame: 6 months
Secondary outcomes:
Other outcomes:
Locations:
city: Chicago
country: United States
facility: Northwestern University
state: Illinois
Study officials:
References:
Clinical trial NCT01756066: A Test of Different Degrees of Cost Sharing on Program Uptake and Attendance
Official title: A Test of Different Degrees of Cost Sharing on Program Uptake and Attendance
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Obesity
Keywords: Obesity
Weight loss program
incentives
Lead sponsor: University of Pennsylvania
Sponsor class: OTHER
Collaborators: name: Harvard University
name: Duke University
First posted: 2012-12-24
Enrollment: 1239
Sex: ALL
Minimum age (years): 18
Maximum age (years): 80
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: PREVENTION

Brief summary: To test the uptake of four different cost sharing discounts for enrolling in the Weight Watchers weight loss program as well as outcomes (program attendance and weight loss) over 12 months.


Eligibility criteria: Inclusion Criteria:

1. Must be employee of Vanguard Health Systems over the age of 18
2. Must have a BMI of 21 or greater

Exclusion Criteria:

1. Must not be under the age of 18
2. Must not have a BMI lower than 21

Primary outcomes:
measure: Uptake
timeFrame: 12 months
Secondary outcomes:
measure: Efficacy
timeFrame: 12 months
Other outcomes:
Locations:
city: Davidson
country: United States
facility: Ingersoll Rand
state: North Carolina
city: Nashville
country: United States
facility: Vanguard Health Systems
state: Tennessee
Study officials:
affiliation: University of Pennsylvania
name: Kevin Volpp, MD, PhD
role: PRINCIPAL_INVESTIGATOR
References:
citation: John LK, Troxel AB, Yancy WS Jr, Friedman J, Zhu J, Yang L, Galvin R, Miller-Kovach K, Halpern SD, Loewenstein G, Volpp K. The Effect of Cost Sharing on an Employee Weight Loss Program: A Randomized Trial. Am J Health Promot. 2018 Jan;32(1):170-176. doi: 10.1177/0890117116671282. Epub 2016 Oct 21.
Clinical trial NCT00877266: Ultrasound Guidance Versus Electrical Stimulation for Perineural Catheter Insertion
Official title: Ultrasound Guidance vs. Electrical Stimulation for Perineural Catheter Insertion: A Randomized, Controlled Trial
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE4
Conditions: Postoperative Pain
Keywords: catheter
ultrasound guidance
nerve stimulation
electrical stimulation
nerve block
UCSD
timed placement
surgery
Catheter Placement Time
Lead sponsor: University of California, San Diego
Sponsor class: OTHER
First posted: 2009-04-07
Enrollment: 180
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: This research study is to determine the relative times for perineural catheter placement with the use of ultrasound versus electrical stimulation. The perineural catheter is placed next to the nerves through which local anesthetic is placed to provide pain control following surgery. This study may determine if one method is associated with increased success rate and patient comfort.

Detailed description: Primary Specific Aim: To determine if the relative times for perineural catheter placement with the use of ultrasound versus electrical stimulation.

Hypothesis: Compared with the use of electrical stimulation, the use of ultrasound guidance when inserting a perineural catheter is associated with a decreased time of placement.

Secondary Specific Aim: To determine if other possible benefits of perineural catheter placement associated with the use of ultrasound guidance versus electrical stimulation.

Hypothesis: Compared with the use of electrical stimulation, the use of ultrasound guidance when inserting a perineural catheter is associated with an increased surgical block success rate and catheter-placement success rate, as well as decreased patient discomfort and incidence of venous puncture.

Eligibility criteria: Inclusion Criteria:

* undergoing surgery with a planned perineural catheter for postoperative analgesia
* catheter in the interscalene, infraclavicular, popliteal, or femoral anatomic location
* age 18 years or older

Exclusion Criteria:

* pregnancy
* inability to communicate with the investigators and hospital staff
* incarceration

Primary outcomes:
measure: The primary outcome measurement will be the time of placement for a perineural catheter using either ultrasound-guided method or electrical stimulation method.
timeFrame: 30 minutes
Secondary outcomes:
measure: Pain and discomfort as assessed by a 0-10 scale (0=no pain/discomfort and 10=worst pain/discomfort imaginable) by the research coordinator.
timeFrame: After catheter placement and Postoperative day 1
Other outcomes:
Locations:
city: San Diego
country: United States
facility: UCSD Medical Center
state: California
Study officials:
affiliation: University of California, San Diego
name: Brian M Ilfeld, M.D., M.S.
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT06930066: Normal Pediatric Liver and Spleen SWE
Official title: Normal Liver and Spleen Stiffness Values Using Shear Wave Elastography in Children
Study type: OBSERVATIONAL
Overall status: NOT_YET_RECRUITING
Conditions: Liver Stiffness
Spleen Stiffness
Shear Wave Elastography in Healthy Children
Normal Organ Elasticity
Pediatric Elastography
Keywords: Shear Wave Elastography
Liver Stiffness
Spleen Stiffness
Pediatric Elastography
Normal Reference Values
Organ Stiffness Measurement
Lead sponsor: Selcuk University
Sponsor class: OTHER
First posted: 2025-04-16
Enrollment: 450
Sex: ALL
Minimum age (years): 1
Maximum age (years): 18
Standard ages: CHILD
ADULT
Accepts healthy volunteers: yes
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: The study population will consist of healthy children aged 0-18 years, with no known liver or spleen pathology. These participants will be selected from pediatric clinics, specifically those who are seeking routine healthy child check-ups and have no underlying diseases. Non-invasive shear wave elastography (SWE) will be used to assess normal liver and spleen stiffness values. Participants will be selected based on inclusion criteria of being free from any liver or spleen disease, and exclusion criteria will ensure that children with known hepatic or splenic conditions are not included. Parental or guardian consent will be obtained for each participant.

Brief summary: This observational study aims to determine normal liver and spleen stiffness values in healthy children using shear wave elastography (SWE). The study will include participants from the pediatric age group without known liver or spleen disease. SWE measurements will be performed non-invasively to establish reference values. The results may contribute to improving diagnostic accuracy in pediatric elastography applications.

Detailed description: Shear wave elastography (SWE) is a non-invasive imaging method used to assess tissue stiffness. While reference values for SWE have been established in adults, data regarding normal liver and spleen stiffness in children are limited. This single-center, cross-sectional observational study aims to establish normative SWE values for the liver and spleen in the pediatric age group. Children with no known liver or spleen pathology will undergo standardized SWE measurement under controlled conditions. Age-specific and sex-specific reference ranges will be analyzed, which may contribute to enhancing the clinical utility of SWE in pediatric practice.

Eligibility criteria: Inclusion Criteria:

* Healthy children aged 0-18 years
* No known liver or spleen pathology
* Written informed consent obtained from parents or guardians

Exclusion Criteria:

* Known liver disease (e.g., hepatitis, cirrhosis)
* Known spleen disease (e.g., splenomegaly)
* Any history of liver or spleen disease
* Age outside the 0-18 years range

Primary outcomes:
measure: Normal liver and spleen stiffness values
timeFrame: Day 1
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
References: