louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT04067817: Norepinephrine and Phenylephrine, Which Better for Elderly?
Official title: Comparison of the Effects of Norepinephrine and Phenylephrine on Tissue Oxygenation and Hemodynamic Stability During an Stroke Volume Variations(SVV) Fluid Guided Therapy in Elderly Undergoing Major Abdominal Surgery
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: PHASE3
Conditions: Hypotension
Keywords: Goal-directed Fluid Therapy
norepinephrine
phenylephrine
elderly
Lead sponsor: The Second Affiliated Hospital of Dalian Medical University
Sponsor class: OTHER
First posted: 2019-08-28
Enrollment: 100
Sex: ALL
Minimum age (years): 60
Maximum age (years): 95
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: this is a prospective, double-blinded and single-center study. this study is based on the Stroke volume variation fluid guided therapy, to compare the effects of norepinephrine and phenylephrine in treating perioperative hypotension, and to find the safest and most effective vasopressor for elderly.


Eligibility criteria: Inclusion Criteria:

* radical resection of colorectal or gastric cancers,
* age over 65 years old,
* surgical time longer than 2hours,
* the American Society of Anesthesiologists(ASA) classification of II or III

Exclusion Criteria:

* history of severe cardiovascular diseases,
* history of severe liver and kidney diseases,
* evidence of arrhythmia on EKG,
* use of positive end-expiratory pressure (PEEP) during mechanical ventilation;
* conditions with relative contraindication for arterial catheterization

Primary outcomes:
measure: hemodynamics- (CO)cardiac output
timeFrame: change from patient enters the operating room to end of operation, assessed up to the whole operation
measure: Tissue perfusion and oxygenation-(DO2) Oxygen delivery;
timeFrame: change from beginning of operation to end of operation, assessed up to the whole operation
measure: Tissue perfusion and oxygenation-(VO2)Oxygen consumption;
timeFrame: change from beginning of operation to end of operation, assessed up to the whole operation
Secondary outcomes:
Other outcomes:
Locations:
city: Dalian
country: China
facility: The Second Hospital of Dalian Medical University
state: Liaoning
Study officials:
affiliation: The Second Affiliated Hospital of Dalian Medical University
name: xiao z yang, MD,PhD
role: STUDY_DIRECTOR
References:
Clinical trial NCT06312917: Effect of Physical Activity Intervention on Overweight and Obese Patients With Endometrial Cancer
Official title: Effects of Physical Activity Based on the Transtheoretical Model on Patients With Endometrial Cancer Undergoing Fertility-sparing Treatment: a Randomized Controlled Trial
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Endometrium Cancer
Physical Activity
Weight Management
Lead sponsor: Peking University People's Hospital
Sponsor class: OTHER
First posted: 2024-03-15
Enrollment: 72
Sex: FEMALE
Minimum age (years): 20
Maximum age (years): 40
Standard ages: ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: This study evaluated the clinical outcome of exercise management on patients with endometrial cancer treated with fertility preservation, including the effect of complete response rate, complete response time, recurrence rate, recurrence time, etc., and physical composition, to evaluate the effectiveness of physical activity on weight management.


Eligibility criteria: Inclusion Criteria:

* Participants were patients who met the following predefined eligibility criteria: Ages 20-40; Overweight or obese; The pathological diagnosis was EC (endometrioid, grade I, no myometrium invasion or metastasis). Not pregnant; Be willing to comply with test requirements after being fully informed of all risks and inconveniences associated with the test.

Exclusion Criteria:

* Recurrent or metastatic disease; Currently participating in regular exercise at least 2 days per week; Pregnant at the start of the study; Or unwilling to comply with research requirements. Patients also completed the Physical Activity Readiness Questionnaire (PAR-Q) through a telephone interview. Patients with one or more potential exercise-related safety risks were excluded.

Primary outcomes:
measure: Body weight
timeFrame: Enrollment，four months after the intervention
measure: BMI
timeFrame: Enrollment，four months after the intervention
measure: physical activity level
timeFrame: Enrollment，four months after the intervention
Secondary outcomes:
measure: serum total cholesterol
timeFrame: Enrollment，four months after the intervention
measure: Waist Hip Ratio
timeFrame: Enrollment，four months after the intervention
measure: triglyceride
timeFrame: Enrollment，four months after the intervention
Other outcomes:
Locations:
city: Beijing
country: China
facility: Peking University People's Hospital
state: Beijing
Study officials:
References:
Clinical trial NCT03355417: A Multiple Baseline Design Study to Investigate the Effectiveness of OT-SI Using an Intensive Intervention Model
Official title: A Multiple Baseline Design Study to Investigate the Effectiveness of OT-SI Using an Intensive Intervention Model
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Motor Coordination or Function; Developmental Disorder
Lead sponsor: Virginia Commonwealth University
Sponsor class: OTHER
First posted: 2017-11-28
Enrollment: 3
Sex: ALL
Minimum age (years): 59
Maximum age (years): 107
Standard ages: CHILD
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Intervention model description: This study will use a non-concurrent multiple baseline design (MBD) where subjects will serve as their own control
Primary purpose: TREATMENT

Brief summary: The investigators hypothesize that children completing 30 sessions of occupational therapy using a sensory integration approach (OT-SI) will demonstrate positive changes in outcome measures related to motor coordination, functional performance and sensory processing (changes pre-post test).


Eligibility criteria: Inclusion Criteria:

* Have a medical diagnosis of "lack of coordination" or "other coordination impairment"
* Children and caregivers able to communicate verbally in English
* Sensory processing impairments as determined by scores in the SPM-H form (screening). Scores must fall in the "definite dysfunction" range in one of three categories (Body Awareness, Balance \& Motion, or Planning \& Ideas), OR fall in the "some problems" range in 2/3 areas.

Exclusion Criteria:

* Diagnosed with autism spectrum disorder or other significant psychological impairment (e.g. bipolar disorder)
* Receiving occupational therapy services at CHoR or another therapy site for more than 3 months
* Significant motor impairment (e.g., cerebral palsy)
* Significant language impairment (e.g., non-verbal, or aphasia)

Primary outcomes:
measure: Change in motor coordination: Jumping Jacks
timeFrame: Baseline to 10 weeks
measure: Change in motor coordination: Finger to Nose Touching
timeFrame: Baseline to 10 weeks
measure: Change in motor coordination: Single Leg Stance Balance
timeFrame: Baseline to 10 weeks
Secondary outcomes:
measure: Change in Sensory Processing Measure-Home Form
timeFrame: Baseline to 10 weeks
measure: Change in Bruinincks-Oseretsky Test of Motor Proficiency (BOT-2) Short-Form
timeFrame: Baseline to 10 weeks
measure: Change in Goal Attainment Scaling
timeFrame: Baseline to 10 weeks
Other outcomes:
Locations:
city: Richmond
country: United States
facility: Children's Hospital of Richmond at VCU
state: Virginia
Study officials:
affiliation: Virginia Commonwealth University
name: Stacey Reynolds, PhD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT06986317: Effectiveness of Positional Release Techniques and Graston Technique In Trigger Point
Official title: Effectiveness of Positional Release Techniques and Graston Technique In Trapezius Trigger Point
Study type: INTERVENTIONAL
Overall status: RECRUITING
Phase: NA
Conditions: Trigger Point Pain, Myofascial
Keywords: Trigger point
Trapezius
Pain
Lead sponsor: Elite College of Management Sciences, Gujranwala, Pakistan
Sponsor class: OTHER
First posted: 2025-05-23
Enrollment: 34
Sex: ALL
Minimum age (years): 18
Maximum age (years): 55
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Intervention model description: This is interventional study.There are 2 groups in this study . One group will be treated with positional release techniques and second group will be treated with graston technique
Primary purpose: TREATMENT

Brief summary: The purpose of the study is to evaluate comparative effectiveness of positional release techniques and graston technique In trapezius trigger point


Eligibility criteria: Inclusion Criteria:

Male and Female

Age group 18-55 years

At least one trigger point

Exclusion Criteria:

* Radiculopathy
* History of head and upper back trauma or surgery
* Tendency to hemorrhage
* Systemic disease

Primary outcomes:
measure: Visual Analogue Scale
timeFrame: 0 week, 1st week, 3rd week
measure: Neck Disability Index
timeFrame: 0 week, 1st week, 3rd week
Secondary outcomes:
measure: Goniometer
timeFrame: 0 week, 1st week, 3rd week
Other outcomes:
Locations:
city: Gujranwala
country: Pakistan
facility: • Al- Raee Hospital Gujranwala • Civil Hospital Gujranwala • Elite college of Management Sciences Gujranwala
state: Punjab
Study officials:
affiliation: Elite College of Management Science
name: Rukhma Mauzzam
role: PRINCIPAL_INVESTIGATOR
References:
citation: Khalid, M., et al. (2023).
citation: Haq, K. and H. Riaz (2022).
citation: Cheatham SW, Lee M, Cain M, Baker R. The efficacy of instrument assisted soft tissue mobilization: a systematic review. J Can Chiropr Assoc. 2016 Sep;60(3):200-211.
citation: Bethers AH, Swanson DC, Sponbeck JK, Mitchell UH, Draper DO, Feland JB, Johnson AW. Positional release therapy and therapeutic massage reduce muscle trigger and tender points. J Bodyw Mov Ther. 2021 Oct;28:264-270. doi: 10.1016/j.jbmt.2021.07.005. Epub 2021 Jul 14.
citation: Lavelle ED, Lavelle W, Smith HS. Myofascial trigger points. Anesthesiol Clin. 2007 Dec;25(4):841-51, vii-iii. doi: 10.1016/j.anclin.2007.07.003.
citation: Bron C, Dommerholt JD. Etiology of myofascial trigger points. Curr Pain Headache Rep. 2012 Oct;16(5):439-44. doi: 10.1007/s11916-012-0289-4.
Clinical trial NCT05694117: A Study of the Intervention Effect of a Hybrid Exercise Program on Elderly With Sarcopenia
Official title: White Box Modeling of Self-Determine Sequence Exercise Program Among Sarcopenic Elderly: Uncovers a Novel Strategy Overcoming Decline of Skeletal Muscle Area
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Sarcopenia
Keywords: sarcopenia
elderly
exercise program
explainable artificial intelligence
Lead sponsor: Northeast Normal University
Sponsor class: OTHER
First posted: 2023-01-23
Enrollment: 392
Sex: ALL
Minimum age (years): 60
Maximum age (years): 75
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: BASIC_SCIENCE

Brief summary: Sarcopenia is a geriatric condition characterized by a progressive decrease in skeletal muscle content and loss of muscle function. Resistance exercise, Taichi exercise and the hybrid exercise program consisting of the two aforementioned methods have been demonstrated could increase the skeletal muscle mass of the elderly with sarcopenia. However, note that the above contents may be performed in a different order in a treatment, equally important but less well understood is the sequence in which it should be performed. Surprisingly, the exercise sequence has not been comprehensively investigated. Therefore, investigators designed a self-ordered exercise program combining resistance exercise, tai chi and a hybrid exercise program to investigate whether the decline in skeletal muscle area could be better overcome and the reversal of sarcopenia in elderly with sarcopenia.


Eligibility criteria: Inclusion Criteria:

1. satisfied the Asian screening criteria for sarcopenia by the Asian Working Group for Sarcopenia;
2. age higher than 60 but less than 75 years of age.

Exclusion Criteria:

1. with serious illness or breathing failure;
2. with neuro-muscular diseases;
3. taking medication that has an effect on the function of skeletal muscles;
4. with conditions relating to the neurological system or the mental health;
5. in another scheduled training plan.

Primary outcomes:
measure: Using quantitative CT to investigate the change of skeletal muscle area in sarcopenic elderly.
timeFrame: Month 6
measure: Using a Jamar hydraulic hand dynamometer to investigate change of handgrip in sarcopenic elderly.
timeFrame: Month 6
measure: Using a bioelectrical impedance body composition analyzer with a multifrequency device to investigate the change of relative skeletal muscle mass index in sarcopenic elderly.
timeFrame: Month 6
Secondary outcomes:
measure: Collect participants' self-evaluation of their life state and physical state.
timeFrame: Month 6
measure: Collect video of participants throughout the intervention.
timeFrame: Month 6
Other outcomes:
Locations:
city: Changchun
country: China
facility: Chinese Center of Exercise Epidemiology
state: Jilin
Study officials:
affiliation: Chinese Center of Exercise Epidemiology
name: Guang Yang
role: STUDY_CHAIR
References:
Clinical trial NCT00535717: Role of Uttarbasti in the Management of Mutra Marga Sankoch (Urethral Stricture)
Official title: Role of Uttarbasti in the Management of Mutra Marga Sankoch (Urethral Stricture)
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE2
Conditions: Urethral Stricture
Keywords: Urethral stricture
Ayurvedic treatment
mutra marg sankoch
uttarbasti
Sesame oil
Honey
Rock salt
Lead sponsor: Maharashtra University of Health Sciences
Sponsor class: OTHER
First posted: 2007-09-26
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: SINGLE_GROUP
Primary purpose: TREATMENT

Brief summary: Uttarbasti is per urethral administration of medicated oil which has been recommended by Sushrut for urinary track disorders.

As far as conventional surgery is concerned urethral stricture still remains a challenge due to post procedural high recurrences and complications

Uttarbasti being almost non invasive, with minimum recurrences and most economical, easy to practice OPD procedure, can be the treatment of choice in the management of urethral stricture.


Eligibility criteria: Inclusion Criteria:

* K/C/O Urethral Stricture of either sex and from all age groups.

Exclusion Criteria:

* With acute UTI.
* DM.
* Neoplasms of lower urinary tract
* BEP.
* With impacted calculus in urethra and bladder neck.

Primary outcomes:
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
affiliation: Maharashtra university of health sciences, Nashik (INDIA)
name: Rajendra H Amilkanthwar, M.D.(Ayu.)
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT02487017: DC-CIK Combined With TACE in the Treatment of Hepatocellular Carcinoma
Official title: Phase 2 Study of DC-CIK Cells Combined With TACE in the Treatment of Hepatocellular Carcinoma
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: PHASE2
Conditions: Hepatocellular Carcinoma
Neoplasms
Digestive System Neoplasms
Lead sponsor: Shenzhen Hornetcorn Bio-technology Company, LTD
Sponsor class: INDUSTRY
Collaborators: name: Yantai City Hospital for Infectious Diseases
First posted: 2015-07-01
Enrollment: 60
Sex: ALL
Minimum age (years): 18
Maximum age (years): 80
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: Evaluation of DC-CIK cells combined TACE treatment for HCC

Detailed description: 60 patients with Hepatocellular Carcinoma, who had received Transcatheter Arterial Chemoembolization (TACE) , will be randomly divided into group A (receive DC-CIK+ TACE treatment) or group B (just receive TACE), and the randomize ratio will be 1:1.

Eligibility criteria: Inclusion Criteria:

* 18-80 years old;
* Histologically confirmed with Hepatocellular Carcinoma at stage I-II;
* Patients who can accept Transcatheter Arterial Chemoembolization ;
* Patients who have a life expectancy of at least 3 months;
* Patients who have a Child-Pugh:A/B; .Eastern Cooperative Oncology Group (ECOG) performance status was 0-2.

Exclusion Criteria:

* White blood cell \<3 x 10\^9/L,Platelet count \<75 x 10\^9/L;BUN and Cr more than normal limits on 3.0 times ;
* Known or suspected allergy to the investigational agent or any agent given in association with this trial;
* Pregnant or lactating patients;
* Known history of Human Immunodeficiency Virus (HIV), Hepatitis C Virus (HCV) or TreponemaPallidun (TP) infection;
* Patients who are suffering from serious autoimmune disease;
* Patients who had used long time or are using immunosuppressant;
* Patients who had active infection;
* Prior use of any anti-cancer treatment in 30 days;
* Now or recently will join another experimental clinical study ;
* History of organ allograft;
* Other situations that the researchers considered unsuitable for this study

Primary outcomes:
measure: Overall survival
timeFrame: 3 years
Secondary outcomes:
measure: Progress-free survival
timeFrame: 3 years
measure: Quality of life (QOL)
timeFrame: 3 years
measure: Phenotypic analysis of T cells
timeFrame: 1 years
Other outcomes:
Locations:
city: Yantai
country: China
facility: Yantai City Hospital for Infectious Diseases
state: Shandong
Study officials:
affiliation: Yantai City Hospital for Infectious Diseases Immunotherapy center
name: Xiangzhong Liu, Professor
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT03373617: The Effect of Anesthesia Type on RIRS
Official title: The Effect of Anesthesia Type on the Surgical Field in Retrograde Intrarenal Surgery With Flexible Ureteroscopy in Renal Stone Patients
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Renal Stone
Lead sponsor: Seoul National University Hospital
Sponsor class: OTHER
Collaborators: name: SMG-SNU Boramae Medical Center
First posted: 2017-12-14
Enrollment: 66
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: Patients requiring RIRS because of renal stone

Brief summary: Retrograde intrarenal surgery (RIRS) with flexible ureteroscopy is based on video monitoring of urinary tract during operation. Therefore, shaking vision on monitor can bother surgeons and make them tired. This can lead in tissue injury from lasing.

The purpose of this study is to investigate the stability of monitoring of surgical field which is assessed by surgeon.

Detailed description: RIRS with flexible ureteroscopy is usually performed under general anesthesia, spinal anesthesia.

Anesthesia type is decided in the basis of medical condition of a patient and patient's preference.

This study is a prospective observational study. During operation after induction of anesthesia, surgeons will be asked how visual stability of surgical field on monitor is (scale from 0 to 10).

According to anesthesia type (general anesthesia, spinal anesthesia), 34 patients will be enrolled and investigated in each group.

Investigators will compare the scale for visual stability of surgical field during RIRS.

Eligibility criteria: Inclusion Criteria:

* Patients requiring RIRS because of renal stone.

Exclusion Criteria:

* disagreement for the trial.

Primary outcomes:
measure: VAS for stability of monitoring
timeFrame: intraoperative
Secondary outcomes:
Other outcomes:
Locations:
city: Seoul
country: Korea, Republic of
facility: Seoul Metropolitan Government Seoul National University Boramae Medical Center
Study officials:
affiliation: SMG-SNU Boramae Medical Center
name: Jung-Man Lee, M.D.,PhD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT06327217: Long Term Results After Hip Arthroscopy
Official title: Long Term Results After Hip Arthroscopy
Study type: OBSERVATIONAL
Overall status: NOT_YET_RECRUITING
Conditions: Femoro Acetabular Impingement
Lead sponsor: Reinier Haga Orthopedisch Centrum
Sponsor class: OTHER
First posted: 2024-03-25
Enrollment: 451
Sex: ALL
Minimum age (years): 16
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Patients from a previous hip arthroscopy cohort study, who are between 5 and 10 years of follow-up.

Brief summary: A common cause of hip joint pain in the young and active population is femoroacetabular impingement (FAI) syndrome. if FAI is left untreated, the changed morphology will have a negative effect on the existing joint and will contribute to the development of osteoarthritis (OA). Hip arthroscopy is the first choice of operative treatment for FAI. While hip arthroscopy improves the patient reported outcome measures (PROMs), the influence of this treatment on the contribution to the development of osteoarthritis after FAI is to the best of our knowledge still unknown.


Eligibility criteria: In order to be eligible to participate in this study, a subject must meet all of the following criteria:

Inclusion Criteria:

* Patient who participated in the cohort study;
* At least 5 years of follow up;
* Patient is able to understand the meaning of the study and is willing to sign the Informed Consent Form.

A potential subject who meets any of the following criteria will be excluded from participation in this study:

Exclusion Criteria:

* Patient who has had hip arthroscopy of both sides;
* Patient is unable or unwilling to sing informed consent

Primary outcomes:
measure: To evaluate the degree of osteoarthritis 5 to 10 years after a hip arthroscopy in comparison with the non-operative side.
timeFrame: 5 to 10 years after hip arthroscopy
Secondary outcomes:
measure: To evaluate the change in degree of osteoarthritis at 5 to 10 years after a hip arthroscopy in comparison with preoperative/perioperative.
timeFrame: 5 to 10 years after hip arthroscopy
measure: To report incidence of total hip replacement within 5 to 10 years after a hip arthroscopy.
timeFrame: 5 to 10 years after hip arthroscopy
measure: To determine the functional outcome of patients and, to determine what factors contribute to a good functional outcome 5/10 years after hip arthroscopy.
timeFrame: 5 to 10 years after hip arthroscopy
measure: To determine the inter-rater and intra-rater agreement of the Kellgren and Lawrence OA score.
timeFrame: 5 to 10 years after hip arthroscopy
measure: To determine patient satisfaction 5-10 years after hip arthroscopy.
timeFrame: 5 to 10 years after hip arthroscopy
Other outcomes:
Locations:
city: Zoetermeer
country: Netherlands
facility: Reinier Haga Orthopedic Center
Study officials:
References: