Clinical trial NCT03374436: Impact of Sprint Stair Climbing "Snacks" on Markers of Metabolism and Vascular Function
Official title: Salivary Insulin Profiles Throughout the Day in Healthy Humans
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Physical Activity
Diet Modification
Lead sponsor: University of British Columbia
Sponsor class: OTHER
Collaborators: name: Mitacs
name: CoreHealth Technologies Inc.
First posted: 2017-12-15
Enrollment: 23
Sex: ALL
Minimum age (years): 18
Maximum age (years): 65
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: CROSSOVER
Intervention model description: Participants complete three conditions in a repeated crossover design.
Primary purpose: OTHER

Brief summary: Prolonged sitting has been shown to impair metabolism and vascular function. The overall purpose of this study is to determine if breaking up prolonged (9 hours) of sitting with brief (\~20 second) stair climbing exercise "snacks" can improve markers of metabolic control and vascular health in healthy young male participants and in males or females with overweight/obesity who are at risk of insulin resistance. An additional purpose is to determine if saliva insulin can be used as a valid indicator of blood insulin when measured throughout the day in sedentary and active conditions and when diets with different amounts of carbohydrates are consumed.


Eligibility criteria: Lean Group Inclusion Criteria:

Non-smoking

Lean Group Exclusion Criteria:

Diagnosed with diabetes or prediabetes (fasting blood sugar more than 6.0 mmol/l) or any other chronic condition that may impact glucose or insulin levels.

BMI is over 25 kg/m2 Take medications which may affect glucose and insulin levels Allergic to eggs. Smoker Competitive or serious endurance athlete.

Overweight/Obese Group Inclusion Criteria:

Elevated waist circumference (\>102 cm for male and \>88 cm for female)

Overweight/Obese Group Exclusion Criteria:

Diagnosed with diabetes (fasting blood sugar more than 7.0 mmol/l) Take medications which may affect glucose and insulin levels Allergic to eggs. Smoker Competitive or serious endurance athlete.

Primary outcomes:
measure: Plasma insulin area under the curve
timeFrame: Measured across 9 hours of each intervention day
Secondary outcomes:
measure: Saliva insulin area under the curve
timeFrame: Measured across 9 hours of each intervention day
measure: Plasma glucose area under the curve
timeFrame: Measured across 9 hours of each intervention day
measure: Plasma triglyceride area under the curve
timeFrame: Measured across 9 hours of each intervention day
measure: Plasma non-esterified fatty acids area under the curve
timeFrame: Measured across 9 hours of each intervention day
measure: Femoral artery flow-mediated dilation
timeFrame: Measured in the morning (time 0 hours) and afternoon (time 8.5 hours) each intervention day
measure: Cerebrovascular function
timeFrame: Measured in the morning (time 0.5 hours) and afternoon (time 6 hours) each intervention day
measure: Cognitive function
timeFrame: Measured in the morning (time 0.5 hours) and afternoon (time 6 hours) each intervention day
Other outcomes:
Locations:
city: Kelowna
country: Canada
facility: University of British Columbia Okanagan
state: British Columbia
Study officials:
References:
citation: Caldwell HG, Coombs GB, Rafiei H, Ainslie PN, Little JP. Hourly staircase sprinting exercise "snacks" improve femoral artery shear patterns but not flow-mediated dilation or cerebrovascular regulation: a pilot study. Appl Physiol Nutr Metab. 2021 May;46(5):521-529. doi: 10.1139/apnm-2020-0562. Epub 2020 Nov 26.