louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT00695734: Detection of Latent Tuberculosis in Hemodialysis Patients
Official title: Interferon-Gamma Release Assays (IGRA) Versus Tuberculin Skin Testing for Detection of Latent Tuberculosis Infection (TB) in Chronic Hemodialysis Patients
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Chronic Renal Failure
Keywords: hemodialysis
end stage renal failure
tuberculosis
latent tuberculosis infection
Patients under hemodialysis for end stage renal failure
Lead sponsor: University Hospital, Geneva
Sponsor class: OTHER
Collaborators: name: Ligue Pulmonaire Genevoise
First posted: 2008-06-12
Enrollment: 62
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: CASE_ONLY
Time perspective: CROSS_SECTIONAL
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Adults aged over 18 Under hemodialysis for \> 3 months End stage renal failure

Brief summary: This study aims to compare the performance of the tuberculin skin test, used for more than 50 years as a diagnostic tool for latent tuberculosis infection, with 2 blood tests which have recently become commercially available (Interferon-gamma release assays) in a population of immunosuppressed individuals with chronic renal failure undergoing long term hemodialysis

Detailed description: This prospective study includes all adults aged over 18 years of age who accept to be included in the study and provided written informed consent. All patients are under long term hemodialysis for chronic renal failure. They are subjected to a questionnaire including history of contacts with tuberculosis (TB), prior treatment for TB, history of prior tuberculin skin testing, history of BCG vaccination, country of origin, trips or prolonged stays in high incidence areas, smoking history, and medications. All patients will have a chest X-ray, and simultaneous testing with the tuberculin skin test according to the Mantoux technique, and with the T-SPOT. TB and QuantiFERON Gold in tube Interferon-gamma release assays. The study analysis agreement between tests, detection of prior TB and presumptive latent tuberculosis infection, based on these items.

Eligibility criteria: Inclusion Criteria:

* Adults aged over 18
* Under hemodialysis for \> 3 months
* End stage renal failure

Exclusion Criteria:

* Refusal to participate
* Prior tuberculin skin test \> 15 mm or any adverse reaction to tuberculin skin test

Primary outcomes:
measure: Relative performance of tuberculin skin test and interferon gamma release assays for detecting latent tuberculosis infection
timeFrame: cross-sectionnal
Secondary outcomes:
measure: Agreement between tuberculin skin test and interferon gamma release assays as well as agreement between interferon gamma release assays
timeFrame: cross-sectionnal
Other outcomes:
Locations:
city: Geneva
country: Switzerland
facility: Geneva University Hospital
state: Geneva 14
Study officials:
affiliation: University Hospital, Geneva
name: Jean-Paul Janssens, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT02795234: Empirical Comperative Study Of Variation Blood Level Antibody Vitamin D at Different Groups Of Patients Compared Healthy Peoples
Official title: Empirical Comperative Study Of Variation Blood Level Antibody Vitamin D at Different Groups Of Patients Compared Healthy Peoples And The Correlation Between Vitamin D Level
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Vitamin D Deficiency
Lead sponsor: Meir Medical Center
Sponsor class: OTHER
First posted: 2016-06-10
Enrollment: 64
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: NON_RANDOMIZED
Intervention model: PARALLEL
Primary purpose: DIAGNOSTIC

Brief summary: The aim of this study is to detect antibodies to vitamin D in the serum at Different Groups of patients and healthy volunteer. A second goal is to find the relation between Vitamin D Antibody and Vitamin D level.

Detailed description: Vitamin D and its metabolites have a significant role in the calcium homeostasis and bone metabolism. Vitamin D deficiency as measured by serum 25(OH)D below 20 ng/mL (50 nmol/L) may contribute to the development of osteoporosis and Osteomalacia.

Several studies have clearly demonstrated that low 25(OH)D levels are associated with more comorbidities, higher estimated cardiovascular risk and autoimmune diseases.

Exposure to the ultraviolet (UV) rays in sunlight is the major source of vitamin D. other sources are dairy products enriched with vitamin D.

Vitamin D deficiency can result from inadequate exposure to sunlight, malabsorption including inflammatory bowel disease, celiac disease and patients undergone resection of the small intestine and inadequate intake of dairy products enriched with vitamin D.

Another possible explanation for vitamin D deficiency is the presence of neutralizing autoantibodies to vitamin D.

The aim of this study is to detect antibodies to vitamin D in the serum at Different Groups of patients and healthy volunteer

At least 64 Blood samples of Patients and healthy volunteer will be tested for the presence of auto-antibodies using an ELISA reader.

The result will compare antibody-positive and antibody-negative individuals with respect of serum 25(OH)D level and other variables and to find the relation between Vitamin D Antibody and Vitamin D level.

Eligibility criteria: Inclusion Criteria:

1. Patients treated in Meir Medical Center
2. Data on serum vitamin D values
3. 18 years old
4. Both sexes
5. Patient hereby declare that he\\she agree to participate the clinical trial

Exclusion Criteria:

1. Patient refuses to sign Informed Consent.
2. Patients without vitamin D values

Primary outcomes:
measure: Presence of Anti Vitamin D Antibodies in Blood Sample
timeFrame: 1 year
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
affiliation: Meir Medical Center
name: reut ohanah
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT02380534: Use of Apheretic Technologies in Cardiovascular Disease
Official title: Use of H.E.L.P. Apheresis in Patients With High Cardiovascular Disease Lp(a)-Related
Study type: INTERVENTIONAL
Overall status: WITHDRAWN
Phase: NA
Conditions: Dyslipidemia
Keywords: High level of Lp(a)
Lead sponsor: University of Pavia
Sponsor class: OTHER
Collaborators: name: Fondazione IRCCS Policlinico San Matteo di Pavia
First posted: 2015-03-05
Enrollment: 0
Sex: ALL
Minimum age (years): 18
Maximum age (years): 70
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: TREATMENT

Brief summary: To evaluate the effects of H.E.L.P. apheresis on lipid profile, Lp(a) level, and some inflammatory adypocytokines in patients with high cardiovascular risk.


Eligibility criteria: Inclusion Criteria:

* high Lp(a) not responsive to diet and pharmacological treatment

Exclusion Criteria:

* heart failure
* hepatic failure
* renal failure

Primary outcomes:
measure: Lp(a) reduction
timeFrame: 1 year
Secondary outcomes:
measure: Inflammatory adypocytokines
timeFrame: 1 year
Other outcomes:
measure: Lipid profile
timeFrame: 1 year
Locations:
city: Pavia
country: Italy
facility: IRCCS Policlinico S. Matteo
Study officials:
References:
Clinical trial NCT01313234: Educational Intervention Targeting Nurses Attitudes and Knowledge About Cancer-related Pain Management
Official title: A Theory Based Educational Intervention Targeting Nurses Attitudes and Knowledge Concerning Cancer-related Pain Management: A Study Protocol of a Quasi-experimental Study Design
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Neoplasms
Lead sponsor: Blekinge Institute of Technology
Sponsor class: OTHER
First posted: 2011-03-11
Enrollment: 60
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NON_RANDOMIZED
Intervention model: PARALLEL
Primary purpose: HEALTH_SERVICES_RESEARCH

Brief summary: The purpose of this study is to investigate whether an intervention consisting of the implementation of guidelines about daily systematic pain assessment following a theory based education, targeting cancer-related pain and pain treatment, lead to a significantly positive improvement in RNs knowledge of, and attitudes towards their pain management. Furthermore will the interventions targeting the RNs influence the admitted patient's perception of their cancer-related pain?


Eligibility criteria: Inclusion Criteria:

* Cancer diagnosis
* Aged 18 years and above
* Cognitively intact and able to verbally communicate
* At admission pain intensity \>1 on Visual Analogue Scale (VAS)

Exclusion Criteria:

* Trauma or planned and/or acute surgery.

Primary outcomes:
measure: Change from baseline of the total score of Knowledge and Attitudes Survey Regarding Pain
timeFrame: Measurement will occur at first session of the educational intervention and 2 and 6 weeks after
Secondary outcomes:
measure: Change from Baseline - Brief Pain Inventory, Short Form (BPI-SF)
timeFrame: Measurement will occur at admission of the patient and at discharge from the hospital. Estimated average time period from admission to discharge is 2 weeks
Other outcomes:
Locations:
city: Karlskrona
country: Sweden
facility: Blekinge Hospital
Study officials:
References:
citation: Gustafsson M, Borglin G. Can a theory-based educational intervention change nurses' knowledge and attitudes concerning cancer pain management? A quasi-experimental design. BMC Health Serv Res. 2013 Aug 19;13:328. doi: 10.1186/1472-6963-13-328.
citation: Borglin G, Gustafsson M, Krona H. A theory-based educational intervention targeting nurses' attitudes and knowledge concerning cancer-related pain management: a study protocol of a quasi-experimental design. BMC Health Serv Res. 2011 Sep 23;11:233. doi: 10.1186/1472-6963-11-233.
Clinical trial NCT02773134: The Early Impact of Postoperative Bracing on Pain and Quality of Life Following Posterior Instrumented Fusion for Lumbar Degenerative Conditions
Official title: The Early Impact of Postoperative Bracing on Pain and Quality of Life Following Posterior Instrumented Fusion for Lumbar Degenerative Conditions: A Randomized Trial
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Lumbar Degenerative Conditions
Keywords: Post-operative Bracing
Rigid Lumbosacral Orthosis
Posterior Spine Fusion
Quality of Life
Lumbar Degenerative Conditions
Lead sponsor: Hopital du Sacre-Coeur de Montreal
Sponsor class: OTHER
First posted: 2016-05-16
Enrollment: 43
Sex: ALL
Minimum age (years): 18
Maximum age (years): 66
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: Braces are commonly prescribed after posterior spinal instrumented fusion (PSIF) in patients with lumbar degenerative conditions with the aim of improving pain relief and quality of life. However, there is a lack of evidence on the indication for postoperative bracing, as surgeons choose to use braces mainly based on their experience and training.

The aim of this study is to investigate whether wearing a brace after PSIF can improve pain relief and quality of life (QOL) 6 weeks and 3 months after surgery.


Eligibility criteria: Inclusion Criteria:

* Patients with degenerative lumbar spine disease (degenerative spondylolisthesis, spinal stenosis, or degenerative disc disease);
* Patients scheduled for an elective posterior spinal fusion.

Exclusion Criteria:

* Patients with obesity (BMI \> 35kg/m2).

Primary outcomes:
measure: Change in Oswestry Disability Index (ODI) score following the surgery.
timeFrame: Baseline, 6 weeks postoperatively, 3 months postoperatively
Secondary outcomes:
measure: Change in SF-12v2 Physical Component Score (PCS)
timeFrame: Baseline, 6 weeks postoperatively, 3 months postoperatively.
measure: Change in SF-12v2 Mental Component Score (MCS)
timeFrame: Baseline, 6 weeks postoperatively, 3 months postoperatively.
measure: Change in Visual Analog Scale (VAS) for back pain
timeFrame: Baseline, 6 weeks postoperatively, 3 months postoperatively.
Other outcomes:
Locations:
Study officials:
References:
Clinical trial NCT03515434: Comparison of Transversus Abdominis Plane Block and Erector Spinae Plane Block in Inguinal Hernia Repair
Official title: The Effectiveness of Erector Spinae Plane Block and Transversus Abdominis Plane Block for Postoperative Analgesia in Inguinal Hernia Repair Undergoing Spinal Anesthesia
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Postoperative Pain
Lead sponsor: Maltepe University
Sponsor class: OTHER
First posted: 2018-05-03
Enrollment: 60
Sex: ALL
Minimum age (years): 18
Maximum age (years): 70
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: CROSSOVER
Primary purpose: TREATMENT

Brief summary: Multimodal analgesia is used to control postoperative pain in inguinal hernia repair. Transversus abdominis plane block is an effective regional anesthesia technique for postoperative analgesia in inguinal hernia repairs. The erector spinae plane block applied to thelow thoracic region was also reported to provide effective analgesia in these surgeries. In this study, we aimed to determine and compare the effects of transversus abdominis plane block and lumbar erector spinae plane block on postoperative pain in inguinal hernia repairs.


Eligibility criteria: Inclusion Criteria:

* inguinal hernia repair under spinal anesthesia, ASA 1-2-3

Exclusion Criteria:

* Patient refusal
* Contraindications to regional anesthesia
* Known allergy to local anesthetics
* Bleeding diathesis
* Use of any anti-coagulants
* Inability to provide informed consent
* Severe kidney or liver disease
* Inability to operate PCA system
* Patient with psychiatric disorders

Primary outcomes:
measure: Numeric Rating Scale
timeFrame: 24 hours
Secondary outcomes:
measure: Tramadol consumption
timeFrame: 24 hours
Other outcomes:
Locations:
city: Istanbul
country: Turkey
facility: Maltepe University faculty of medicine
Study officials:
affiliation: Maltepe University
name: serkan Tulgar, ass prof
role: PRINCIPAL_INVESTIGATOR
References:
citation: Venkatraman R, Abhinaya RJ, Sakthivel A, Sivarajan G. Efficacy of ultrasound-guided transversus abdominis plane block for postoperative analgesia in patients undergoing inguinal hernia repair. Local Reg Anesth. 2016 Jan 18;9:7-12. doi: 10.2147/LRA.S93673. eCollection 2016.
citation: Takebayashi K, Matsumura M, Kawai Y, Hoashi T, Katsura N, Fukuda S, Shimizu K, Inada T, Sato M. Efficacy of transversus abdominis plane block and rectus sheath block in laparoscopic inguinal hernia surgery. Int Surg. 2015 Apr;100(4):666-71. doi: 10.9738/INTSURG-D-14-00193.1.
citation: Hernandez MA, Palazzi L, Lapalma J, Cravero J. Erector spinae plane block for inguinal hernia repair in preterm infants. Paediatr Anaesth. 2018 Mar;28(3):298-299. doi: 10.1111/pan.13325. Epub 2018 Jan 17.
Clinical trial NCT04382534: A Cross-sectional and Cohort Study of COVID-19 Patients With Post - Discharge Dysfunction
Official title: A Cross-sectional and Cohort Study of COVID-19 Patients With Post - Discharge Dysfunction
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Covid19
Respiratory Rehabilitation
Cross-sectional Study
Cohort Study
Lead sponsor: Peking University Third Hospital
Sponsor class: OTHER
First posted: 2020-05-11
Enrollment: 300
Sex: ALL
Minimum age (years): 18
Maximum age (years): 80
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Patients with COVID-19 after discharge

Brief summary: Post-discharge rehabilitation regimens for covid-19 patients have not been supported by high-quality evidence-based medical evidence.The first part of this study is a cross-sectional study.The contents of the study were the factors related to the dysfunction of COVID - 19 patients after discharge from the hospital in Wuhan.The second part of this study is a cohort study.To observe the functional changes of COVID-19 patients after discharge in hospital rehabilitation, home rehabilitation and no rehabilitation, in order to propose a more safe and effective rehabilitation program.


Eligibility criteria: Inclusion Criteria:

* patients with definite diagnosis of COVID-19 normal or severe
* patients who entered the isolation point \<3 days after discharge
* 18-80 years old
* agree to join the queue

Exclusion Criteria:

* body temperature \>38°C
* heart rate \>120 times/min or \<40 times/min, systolic blood pressure \<90mmHg or \>180mmHg, respiratory rate \>25 times/min in calm state.Or above vital signs fluctuate significantly.
* continuous oxygen therapy is required.
* patients with myocarditis, pulmonary hypertension, congestive heart failure, fresh venous thromboembolic diseases, unstable fractures and other inappropriate exercise
* patients with consciousness disorders, severe sequelae of cerebral infarction, cognitive dysfunction, mental disorders, severe balance disorders, and severe bone and joint diseases, which affect evaluation and treatment
* other conditions that cannot be cooperated with rehabilitation treatment

Primary outcomes:
measure: Symptoms and signs
timeFrame: Ten days
measure: Respiratory function
timeFrame: Ten days
measure: The body function
timeFrame: Ten days
measure: ADL
timeFrame: Ten days
Secondary outcomes:
Other outcomes:
Locations:
city: Wuhan
country: China
facility: Huarunwugang general hospital
state: Hubei
Study officials:
References:
Clinical trial NCT01991834: Antibiotic Prophylaxis in Gynecologic Laparoscopy
Official title: Antibiotic Prophylaxis in Gynecologic Laparoscopy
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Infection Secondary to Surgical Procedure
Keywords: laparoscopy
surgical wound infection
antibiotic prophylaxis
gynecologic surgical procedures
Lead sponsor: Universidade do Vale do Sapucai
Sponsor class: OTHER
First posted: 2013-11-25
Enrollment: 114
Sex: FEMALE
Minimum age (years): 18
Maximum age (years): 65
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: PREVENTION

Brief summary: Laparoscopy is a surgical procedure indicated for most gynecological pathologies and presents numerous advantages over laparotomy, among them lower rates of surgical site infection and less comorbidity feverish. Despite this, the use of antibiotic prophylaxis is widely accepted and performed by most gynecologists. However, there isn't literature evidence to support the routine use of antibiotics in the prophylaxis of wound infection on laparoscopic pelvic surgery .Therefore, this study will evaluate the need for the use of antibiotic prophylaxis in gynecological laparoscopies not including opening hollow viscera.

Detailed description: It is a clinical, prospective, double-blind, randomized study. 114 women with gynecologic disease, in which there is indication of laparoscopic surgical approach, will be consecutively select. These women will be allocated in two arms, control and study, where control group will use placebo and study will receive intravenous cephazolin. These patients will be followed for 30 days according to Centers for Disease Control and Prevention criteria.

Eligibility criteria: Inclusion Criteria:

* patients with gynecologic disease, undergoing gynecologic laparoscopy without opening hollow viscera.

Exclusion Criteria:

* body mass index over 30 Kg/m2
* smoking
* diabetes type I or II with glycated hemoglobin exceeding 6.5%
* patients who are at surgical risk classification of the American Society of Anesthesiologists(ASA) as ASA III or higher
* refusal to participate
* postoperative antibiotic therapy for another indication clinical complication

Primary outcomes:
measure: Surgical site infection
timeFrame: 30 days
Secondary outcomes:
Other outcomes:
Locations:
city: Pouso Alegre
country: Brazil
facility: Hospital das Clinicas Samuel Libanio
state: Minas Gerais
city: Pouso Alegre
country: Brazil
facility: Hospital e Maternidade Santa Paula
state: Minas Gerais
Study officials:
affiliation: Universidade do Vale do Sapucai
name: Fabiola SM Campos, MD
role: PRINCIPAL_INVESTIGATOR
affiliation: Universidade do Vale do Sapucai
name: Daniela F Veiga, MD, PhD
role: STUDY_CHAIR
References:
Clinical trial NCT05699434: Obstetrics and Gynecology Residents and Experts' Knowledge of, Attitudes Toward, Practice Behaviors, and Self-confidence Levels of Caring for Lesbian, Bisexual, and Transgender (LBT+) Patients in Turkey; A Descriptive-cross Sectional Study
Official title: Obstetrics and Gynecology Residents and Experts' Knowledge of, Attitudes Toward, Practice Behaviors, and Self-confidence Levels of Caring for Lesbian, Bisexual, and Transgender (LBT+) Patients in Turkey; A Descriptive-cross Sectional Study
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Knowledge, Attitudes, Practice
Keywords: LGBT
attitude
knowledge
practice behaviour
self confidence
Lead sponsor: Kanuni Sultan Suleyman Training and Research Hospital
Sponsor class: OTHER
First posted: 2023-01-26
Enrollment: 189
Sex: ALL
Minimum age (years): 18
Maximum age (years): 60
Standard ages: ADULT
Accepts healthy volunteers: yes
Observational model: ECOLOGIC_OR_COMMUNITY
Time perspective: CROSS_SECTIONAL
Sampling method: PROBABILITY_SAMPLE
Study population: Turkish Obstetrics and Gynecologists (residents and experts) working active in Istanbul

Brief summary: Obstetrics and Gynecology residents and experts' knowledge of, attitudes toward, practice behaviors, and self-confidence levels of caring for lesbian, bisexual, and transgender (LBT+) patients in Turkey; A descriptive-cross sectional study

Detailed description: There are various studies about LGBT people's problems while utilizing healthcare services and interactions with physicians in Turkey and other countries. There is a lack in the curriculum for obstetricians and gynecologists regarding LGBT individuals' healthcare problems. In this study, we tried to evaluate obstetrics and gynecology residents/experts' knowledge level about LGBT individuals, attitudes toward these sexual minority individuals in their clinical practices, practice behaviors and experience levels about this condition, and their confidence level about caring for sexual minority individuals by performing cross-sectional study using online survey platform.

Eligibility criteria: Inclusion Criteria:

* work actively as an Obstetrician and Gynecologist in Istanbul/Turkey

Exclusion Criteria:

* retired clinicians
* LGBT individuals working as Obstetrician and Gynecologist

Primary outcomes:
measure: Obstetrics and Gynecology residents and experts' knowledge of, attitudes toward, practice behaviors, and self-confidence levels of caring for lesbian, bisexual, and transgender (LBT+) patients
timeFrame: Time Frame: 2 months
Secondary outcomes:
Other outcomes:
Locations:
city: İstanbul
country: Turkey
facility: Kanuni Sultan Suleyman Training and Research Hospital
Study officials:
References: