Clinical trial NCT00878306: Disulfiram Interactions With HIV Medications: Clinical Implications
Official title: Disulfiram Interactions With HIV Medications: Clinical Implications
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE1
Conditions: HIV Infections
Drug Abuse
Keywords: Treatment of drug dependency with HIV medications
HIV
Lead sponsor: University of California, San Francisco
Sponsor class: OTHER
Collaborators: name: National Institute on Drug Abuse (NIDA)
First posted: 2009-04-08
Enrollment: 40
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: SINGLE_GROUP

Brief summary: The purpose of this study is to determine whether disulfiram might be a safe and effective treatment for cocaine and/or alcohol dependence in patients with HIV disease. This research is designed to characterize the presence or absence of significant drug interactions between disulfiram and HIV medications using standard clinical pharmacology techniques as well as monitor any side effects that might occur when these medications are administered together.

Detailed description: Cocaine and alcohol abuse are strongly linked to HIV infection and transmission of the virus. Disulfiram has long been approved by the US FDA for the treatment of alcohol and recent data shows it to be effective in reducing cocaine abuse. Disulfiram and antiretroviral medications (ARV) are metabolized by cytochrome P450 3A and concomitant use of these drugs could potentially produce adverse drug interactions underscoring the need to identify and understand the clinical implications of these drug interactions in order to more effectively treat individuals with both HIV disease and cocaine and/or alcohol use disorders. This will be accomplished by conducting studies aimed at identifying whether pharmacokinetic or pharmacodynamic drug interactions of importance occur between disulfiram and medications frequently utilized in those with HIV/AIDS.

Abuse of cocaine and/or alcohol has been shown to be a significant risk factor for HIV infections as a result of high risk sexual and drug use behaviors occurring in the context of use of these substances. Those with HIV infection and untreated cocaine and/or alcohol dependence are also at a high risk of transmitting HIV to others. Moreover, those with HIV disease and substance dependence often experience poor clinical outcomes as a result of nonadherence to HIV treatment regimens.

Disulfiram (DIS) is an inhibitor of ALDH and has been reported to alter hepatic cytochrome P450 enzyme function important to metabolism of many drugs frequently used in the treatment of HIV/AIDS. Although approved for the treatment of alcohol dependence, DIS has been studied as a treatment for cocaine addiction in recent years. DIS at the standard 250 mg daily dose has been associated with significant reductions in cocaine use as well as alcohol use in those with histories of concomitant cocaine-alcohol abuse. DIS 250 mg daily has been shown to have a significant pharmacokinetic interaction with cocaine resulting in delayed cocaine clearance. In order to more fully access possible use of DIS treatment for cocaine and/or alcohol dependence in this population, it is important to determine if any excess risk is conveyed as a result of drug interactions that might occur between DIS and the ARV medications.

This study will be using a standard clinical pharmacology study design using a within-subject design examining the two drug interaction studies between DIS (250 mg daily) and the following medications:

1. Non-nucleoside reverse transcriptase inhibitor, efavirenz 600 mg daily for 10 days
2. Protease inhibitors atazanavir 400 mg daily for 8 days or ritonavir 200 mg daily for 8 days

   Additional data will be collected and analyzed including:
3. Clinical data on effects of these medications alone and in combination on cardiac conduction, hepatic function, and serum lipids will be obtained
4. The safety of co-administration of alcohol containing HIV preparations (ritonavir) with DIS will be determined
5. The effect of ARV on DIS function as determined by ALDH activity and DIS and metabolite concentrations will be determined using a control sample within-subject design (DIS doses of 62.5 mg and 250 mg daily) and between subjects design.

Eligibility criteria: Inclusion Criteria:

* Good health and without clinical findings that require medical or psychiatric intervention as determined by a physical and mental status examination and screening laboratory tests, urinalysis, and ECG
* 18 years of age or older
* Willing to abstain from alcohol during the study and for two weeks afterward

Exclusion Criteria:

* Patients who are receiving concurrently other drugs that are inducers or inhibitors of hepatic microsomal enzymes
* Patients with a known sensitivity to the HIV therapeutics to be studied
* Pregnant or nursing mothers
* Current major affective or psychotic illnesses or suicidality
* Clinically active hepatitis
* Diabetes, hyperlipidemia, coagulation disorders, or renal disease will be excluded
* Those meeting criteria for current alcohol or drug dependence (other than nicotine)
* HIV infection

Primary outcomes:
measure: The effect of disulfiram on the pharmacokinetics of each of the antiretroviral medications to be studied
timeFrame: Measured at Day 15
Secondary outcomes:
measure: The effect of the antiretroviral medications on disulfiram measured by ALDH activity and disulfiram pharmacokinetics
timeFrame: Measured at Day 0, Day 4, and Day 8
measure: Cardiac Conduction
timeFrame: Measured at screening and during pharmacokinetic studies
measure: Hepatic Function
timeFrame: Measured at screening and during pharmacokinetic studies
measure: Serum Lipids
timeFrame: Measured at screening and during pharmacokinetic studies
measure: Safety of co-administration of alcohol containing HIV preparations (ritonavir) and Disulfiram
timeFrame: Measured at day 11- day 15
Other outcomes:
Locations:
city: San Francisco
country: United States
facility: San Francisco General Hospital
state: California
Study officials:
affiliation: University of California, San Francisco
name: Elinore F McCance-Katz, M.D., Ph.D
role: PRINCIPAL_INVESTIGATOR
References: