Clinical trial NCT04816253: Controlling Post-extraction Complications of Impacted Mandibular Third Molar
Official title: Methylprednisolone and Hyaluronic Acid Versus Each Agent Alone to Control Post-extraction Complications of Impacted Mandibular Third Molar
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Preventing Postextraction Complication
Lead sponsor: Al-Azhar University
Sponsor class: OTHER
First posted: 2021-03-25
Enrollment: 72
Sex: ALL
Minimum age (years): 20
Maximum age (years): 35
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: Impacted mandibular 3rd molar will be extracted in all patients, then patients will be divided, according to material placed in extraction socket into 3 groups: control, hyaluronic acid and honey. Then post extraction complications will be evaluated

Detailed description: Impacted Mandibular third molar will be extracted under local anesthesia Through standard surgical flap elevation, after extraction and wound irrigation a material facilitate healing will be placed. According to material will be placed patients will be divide into 3 group: control ( no material, second group hyaluronic acid, third group ( honey).. then wound will be closed. Postoperative pain ( through visual analog scale) , edema, total dose of analgesic, mandibular movement (interincisal distance in mm) will be evaluated preoperative, 1,2,3,7, and 10 day after extraction

Eligibility criteria: Inclusion Criteria:

* healthy patients
* patient has impacted 3rd molar

Exclusion Criteria:

* medically compromised patients Heavy smoking patients

Primary outcomes:
measure: Interincisal distance
timeFrame: Baseline (Preoperative)
measure: Interincisal distance
timeFrame: 1 day postoperative
measure: Interincisal distance
timeFrame: 2nd day postoperative
measure: Interincisal distance
timeFrame: 3rd day postoperative
measure: Interincisal distance
timeFrame: 7th day postoperative
measure: Assessment of pain using Visual analog scale
timeFrame: Baseline (Preoperative)
measure: Assessment of pain using Visual analog scale
timeFrame: 1st day
measure: Assessment of pain using Visual analog scale
timeFrame: 2nd day
measure: Assessment of pain using Visual analog scale
timeFrame: 3rd day
measure: Assessment of pain using Visual analog scale
timeFrame: 7th day
measure: Total amount of analgesic
timeFrame: 1st day postoperative
measure: Total amount of analgesic
timeFrame: 2nd day postoperative
measure: Total amount of analgesic
timeFrame: 3rd day postoperative
measure: Total amount of analgesic
timeFrame: 7th day postoperative
measure: Size of edema will be assessed from finial angle and Travis of ear to mental ala of Nes and mouth angle
timeFrame: Baseline
measure: Size of edema will be assessed from finial angle and Travis of ear to mental ala of Nes and mouth angle
timeFrame: 1st day postoperative
measure: Size of edema will be assessed from finial angle and Travis of ear to mental ala of Nes and mouth angle
timeFrame: 2nd day postoperative
measure: Size of edema will be assessed from finial angle and Travis of ear to mental ala of Nes and mouth angle
timeFrame: 3rd day postoperative
measure: Size of edema will be assessed from finial angle and Travis of ear to mental ala of Nes and mouth angle
timeFrame: 7th day postoperative
Secondary outcomes:
Other outcomes:
Locations:
city: Jeddah
country: Saudi Arabia
facility: Vision college
Study officials:
References: