Clinical trial NCT01319513: Post-exercise Dietary Protein Strategies
Official title: The Effect of the Pattern Post-exercise Aminoacidemia on Myofibrillar Protein Synthesis
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Optimal Anabolic Nutrition Interventions
Lead sponsor: McMaster University
Sponsor class: OTHER
Collaborators: name: RMIT University
name: Australian Institute of Sport
name: Nestec Ltd.
First posted: 2011-03-21
Enrollment: 8
Sex: MALE
Minimum age (years): 18
Maximum age (years): 35
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: CROSSOVER

Brief summary: Protein ingestion increases the rate at which the body builds new proteins in skeletal muscle (muscle protein synthesis. This study is designed to examine how the pattern of feeding affects muscle protein synthesis following resistance exercise. There is reason to believe that the large rapid increase in blood amino acid concentrations that accompanies the ingestion of a bolus of protein is important to increasing muscle protein synthesis. Thus, we hypothesize that the consumption a bolus of protein will elevate muscle protein synthesis to a greater extent than the consumption of an equivalent amount of protein that is consumed in small divided doses.

Detailed description: The rapid appearance into the blood of essential amino acids, and leucine in particular, may act as an important signal to stimulate muscle protein synthesis after resistance exercise. This may explain why consuming rapidly-absorbed whey protein may have an anabolic edge over slowly-absorbed proteins such as casein. Previous investigations into importance of the rate of absorption to muscle protein synthesis that have used 'fast' and 'slow' proteins have been confounded by differences in amino acid composition. The present study addresses this issue by administering the same protein source, whey, as either a bolus or in small divided 'pulse' doses to achieve divergent amino acid profiles after a bout of resistance exercise.

This study is being conducted in young (18-35) men.

Our outcome measures include: blood amino acid concentrations, rates of myofibrillar protein synthesis, anabolic intracellular signalling markers

Eligibility criteria: Inclusion Criteria:

* Non-obese men (BMI \<27) between the age of 18 and 35 yrs.

Exclusion Criteria:

* Type II diabetes or other known diseases
* Use of medication
* Female
* Other ages or BMI than indicated above
* Resistance training \> 3X/wk

Primary outcomes:
measure: Rate of myofibrillar protein synthesis
timeFrame: 4 months
Secondary outcomes:
measure: Myocellular protein phosphorylation
timeFrame: 4 months
Other outcomes:
Locations:
city: Hamilton
country: Canada
facility: Ivor Wynne Centre A103, McMaster University
state: Ontario
Study officials:
affiliation: McMaster University
name: Stuart M Phillips, PhD
role: PRINCIPAL_INVESTIGATOR
References:
citation: West DW, Burd NA, Coffey VG, Baker SK, Burke LM, Hawley JA, Moore DR, Stellingwerff T, Phillips SM. Rapid aminoacidemia enhances myofibrillar protein synthesis and anabolic intramuscular signaling responses after resistance exercise. Am J Clin Nutr. 2011 Sep;94(3):795-803. doi: 10.3945/ajcn.111.013722. Epub 2011 Jul 27.