louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT02778659: Hypnotic Intake and Motor and Cognitive Performances at High Altitude
Official title: The Effect of Acute Hypnotic Intake Before a Night at High Altitude on Cognitive and Motor Performances
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Physiology
Lead sponsor: Centre d'Expertise sur l'Altitude EXALT
Sponsor class: OTHER
First posted: 2016-05-20
Enrollment: 22
Sex: ALL
Minimum age (years): 18
Maximum age (years): 60
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: CROSSOVER
Primary purpose: BASIC_SCIENCE

Brief summary: This study aims to determine the effect of acute hypnotic intake (Zolpidem) on sleep, cognitive and motor performances and on acute mountain sickness symptoms at high altitude. Healthy subjects will be evaluated on 4 occasions (twice at sea level and twice at high altitude), after hypnotic or placebo intake. Following an early wake-up (01:00), symptoms, cognitive and motor performances will be assessed to determine potential residual effects of Zolpidem within such conditions.


Eligibility criteria: Inclusion Criteria:

* No sojourn above 2500 m during the past 2 months
* Coffee intake \< 3 cups per day
* Non-smoker

Exclusion Criteria:

* Respiratory, cardiovascular, metabolic or neuromuscular diseases
* Psychiatric disorders
* Use of hypnotics within the past year
* Dependence syndrome (alcool, drugs, etc)
* Severe insomnia or somnolence

Primary outcomes:
measure: Cognitive performance assessed using Simon cognitive test
timeFrame: 4 hours after drug/placebo intake
Secondary outcomes:
Other outcomes:
Locations:
city: Grenoble
country: France
facility: Grenoble University Hospital
state: Rhone Alpes
Study officials:
affiliation: University Hospital, Grenoble
name: Pierre Bouzat, MD PhD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT03348059: Anti-E1E2 (D32.10 Epitope-binding) Antibodies Status Prior Therapy Favors Direct-acting Antiviral Treatment Efficacy
Official title: Anti-E1E2 (D32.10 Epitope-binding) Antibodies Status Prior Therapy Favors Direct-acting Antiviral Treatment Efficacy
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Chronic Hepatitis c
Lead sponsor: Hospices Civils de Lyon
Sponsor class: OTHER
First posted: 2017-11-20
Enrollment: 103
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Observational model: COHORT
Time perspective: RETROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Hepatitis C virus (HCV)-infected patients treated with direct-acting antiviral treatment

Brief summary: The hypothesis was to check whether baseline anti-E1E2 antibodies could predict virological outcome in Hepatitis C virus (HCV)-infected patients receiving direct-acting antiviral treatment

Detailed description: Presence of anti-E1E2 antibodies was previously associated with spontaneous cure of hepatitis C virus (HCV). The hypothesis was to check whether baseline anti-E1E2 antibodies could predict virological outcome in HCV-infected patients receiving direct-acting antiviral treatment

Eligibility criteria: Inclusion Criteria:

* 18 years of age or older
* HCV patients treated with direct-acting antiviral treatment
* Patients with a prior treatment blood sample
* Patients with sustained virological response or virological relapse

Exclusion Criteria:

* HIV or hepatitis B virus (HBV) coinfection

Primary outcomes:
measure: Proportion of patients with positive anti-E1E2 antibody level at treatment initiation
timeFrame: Baseline (treatment initiation day)
Secondary outcomes:
Other outcomes:
Locations:
city: Lyon
country: France
facility: Croix-Rousse Hospital, Hospices Civils de Lyon
Study officials:
References:
Clinical trial NCT05931159: Effects of AHEs on DrA in Postpartum Women
Official title: Effects of Abdominal Hypopressive Exercises on Diastasis Recti in Postpartum Women
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Diastasis Recti
Keywords: Diastasis Recti
Diastasis Recti and weakness of Linea alba
Low back pain
Lead sponsor: Riphah International University
Sponsor class: OTHER
First posted: 2023-07-05
Enrollment: 38
Sex: FEMALE
Minimum age (years): 18
Maximum age (years): 45
Standard ages: ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: This study is aimed to determine the effects of Abdominal Hypopressive exercises on IRD, Lumbopelvic pain, Body Image and abdominal muscle function in postpartum women.

Detailed description: Postnatal women wish to resume abdominal exercises shortly after delivery to improve trunk function and restore the pre-pregnant state of the body. Diastasis recti is a common occurrence in the postpartum period which is associated with both physical impairments and body image concerns. Despite the high prevalence, treatment options are still being explored to identify the best approach to resolve it. Exercise is a conservative method to reduce IRD and improve the associated symptoms and quality of life of postpartum females. Most of the previous studies have used either digital nylon calipers or digital palpation methods for the outcome assessment of DrA which has important implications. Fewer studies have used the gold standard US diagnosis. Despite various studies being conducted on the effect of exercise on DrA, the results are still nonconclusive with a deficiency of a standardized protocol. Multifaceted and clinically meaningful assessments have been proposed to be investigated by the previous literature.

Eligibility criteria: Inclusion Criteria:

* 12 weeks to 36 weeks postpartum
* Both vaginal delivery and C-section
* Lumbopelvic pain (NPRS \>4)
* Diagnosis of DrA by calliper: 3 cm below the umbilicus: \>22 mm, at the umbilicus: \>20 mm, 3 cm above the umbilicus: \>14 mm
* Primiparous females

Exclusion Criteria:

* Any conditions affecting the ability to perform exercise or activity of daily living.
* Previous spinal or abdominal surgery, and neuromuscular diseases.
* Severe DrA \>5cm with the herniation or requiring surgical repair.
* LBP associated with disc herniation, spondylolysis, and degenerative changes of the spine

Primary outcomes:
measure: Inter Recti Distance
timeFrame: 8th Week
measure: Lumbopelvic Pain
timeFrame: 8th Week
measure: The Oswestry Disability Index
timeFrame: 8th Week
Secondary outcomes:
measure: Body Shape Questionnaire
timeFrame: 8th Week
measure: Double Leg lowering test
timeFrame: 8th Week
Other outcomes:
Locations:
city: Rawalpindi
country: Pakistan
facility: Attock Hospital (Private) Limited
state: Punjab
Study officials:
affiliation: Riphah International University
name: Sarah Ehsan, PP-DPT
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT03016559: Effect of Releasing Quadratus Lumborum Muscle on Hip Joint Range of Motion in Asymptomatic Individuals
Official title: Effect of Releasing Quadratus Lumborum Muscle on Angles of Hip Joint in Asymptomatic Individuals
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Muscle
Keywords: releasing muscle
quadratus lumborum
hip angle
Lead sponsor: Mahidol University
Sponsor class: OTHER
First posted: 2017-01-10
Enrollment: 30
Sex: ALL
Minimum age (years): 19
Maximum age (years): 23
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: OTHER

Brief summary: The purpose of this study are to compare angles of hip joint between before and after releasing quadratus lumborum muscle.

Detailed description: The 1st physical therapist performed the modified Thomas test position. The participant was asked to lie supine over the edge of the couch. The participant hold one knee to the chest tightly while the other knee was bent over the end of the couch. The 2nd physical therapist measured angles of hip and knee using a standard goniometer at baseline. The quadratus lumborum muscle was released. Then the same measurement was repeated.

Eligibility criteria: Inclusion Criteria:

1. asymptomatic male and female volunteers
2. age 18-65 years

Exclusion Criteria:

1. having musculoskeletal symptoms (e.g. fibromyalgia, pain at any regions, instability of lower extremities caused by ligamentous injury, injury or trauma to lower extremities), endocrine disease, rheumatoid arthritis
2. taking muscle relaxant or pain killer within 1 day prior to data collection
3. having past history of low back and hip surgery
4. pregnancy
5. having menstruation on data collection day
6. having joint deformities (e.g. knock knee, bow leg)

Primary outcomes:
measure: Hip abduction angle
timeFrame: 5 minutes
Secondary outcomes:
measure: Hip flexion angle
timeFrame: 5 minutes
Other outcomes:
measure: Knee flexion angle
timeFrame: 5 minutes
Locations:
Study officials:
affiliation: Mahidol University
name: Chompunoot Suwanasri, MSc
role: PRINCIPAL_INVESTIGATOR
References:
citation: Jairakdee Y, Chansirinukor W, Sitti T. Effect of releasing quadratus lumborum muscle on hip and knee muscle length in asymptomatic individuals. J Bodyw Mov Ther. 2021 Apr;26:542-547. doi: 10.1016/j.jbmt.2020.11.008. Epub 2020 Nov 7.
Clinical trial NCT05702359: Acute Effects of Juice Consumption With Biofunctional Compounds and Probiotics on Glucose Metabolism
Official title: Acute Effects of Fruit Juice Enriched With Vitamin D3 or n-3 Fatty Acids or Probiotics and the Combination of the Three Ingredients on Glucose Metabolism in Healthy Adults
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Potential Abnormality of Glucose Tolerance
Appetite Disorders
Keywords: blood glucose
insulin
glycemic index
glycemic load
juices
probiotics
vitamin D3
n-3 fatty acids
Lead sponsor: Agricultural University of Athens
Sponsor class: OTHER
First posted: 2023-01-27
Enrollment: 11
Sex: ALL
Minimum age (years): 18
Maximum age (years): 55
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: CROSSOVER
Intervention model description: Crossover assignment
Primary purpose: OTHER

Brief summary: This study investigated the short-term effects of fruit juice enriched with Vitamin D3 or n-3 PUFA or probiotics and the combination of the three ingredients on glucose metabolism.

Detailed description: This study aimed to 1. Determine the glycemic index and glycemic load of mixed fruit juice (pomegranate, grape, apple, and orange) enriched with Vitamin D3 or n-3 PUFA or probiotics, and the combination of the three bio-functional ingredients, compared to regular mixed fruit juice and the reference food (D-glucose), and 2.Examine the short-term effects of the five mixed fruit juices on postprandial blood glucose and salivary insulin responses, blood pressure, and subjective appetite, in healthy adults.

Eligibility criteria: Inclusion Criteria:

* Healthy
* Non-smoking
* Non-diabetic men and women
* Body mass index between 18.5 and 25 kg.m2

Exclusion Criteria:

* Severe chronic disease (e.g. cardiovascular diseases, diabetes mellitus, kidney or liver conditions, endocrine conditions)
* Gastrointestinal disorders
* Pregnancy
* Lactation
* Competitive sports
* Alcohol abuse
* Drug dependency

Primary outcomes:
measure: Capillary blood glucose responses
timeFrame: 3 hours
Secondary outcomes:
measure: Salivary insulin responses
timeFrame: 3 hours
measure: Subjective appetite rating
timeFrame: 3 hours
measure: Blood pressure
timeFrame: 3 hours
Other outcomes:
Locations:
city: Athens
country: Greece
facility: Agricultural University of Athens
state: Attica
Study officials:
affiliation: Agricultural University of Athens
name: Emilia Papakonstantinou, PhD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT01118000: Study on the Cardioprotection and Humoral Mechanism of Limb Ischemia Preconditioning
Official title: Study on the Cardioprotection and Humoral Mechanism of Limb Ischemia Preconditioning
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Ischemic Preconditioning
Keywords: ischemic preconditioning,serum proteins,human
Lead sponsor: Sun Yat-sen University
Sponsor class: OTHER
First posted: 2010-05-06
Enrollment: 60
Sex: ALL
Minimum age (years): 20
Maximum age (years): 30
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: SINGLE_GROUP
Primary purpose: TREATMENT

Brief summary: Numerous studies Have shown that limb ischemic preconditioning can protect vital organs (including the heart) from ischemia-reperfusion injury,which has a broad application prospect.But its mechanism is still unclear. Evidence showed that humoral mechanisms may play an important role. This study was carried out on the limb ischemic preconditioning in healthy volunteers, collected their serum at different time points before and after treatment,classified and identified the serum proteins during different periods of limb ischemic preconditioning,by using methods including high abundant protein removal,Two-dimensional electrophoresis chromatography and mass spectrometry,then analysed activation and synthesis of the proteins in order to search for the proteins or peptides whose synthesis was activated by ischemic preconditioning. This study will be the first systemic explore of the changes in serum proteins of limb ischemic preconditioning in human body,and lay theoretical basis for the clinical application of limb ischemic preconditioning and for further explore of its humoral mechanism,thus provide clues for searching for protein or peptide having protective effects for organs.

Detailed description: We aim to assess whether limb ischemic preconditioning protects remote tissue or organs through a humoral mechanism.

Eligibility criteria: Inclusion Criteria:

* healthy volunteers aging 20-30 years old
* no cardiac，hepatic or renal，peripheral vascular diseases
* be willing to enter our study and sign an written informed consent

Exclusion Criteria:

* younger than 20 years old or older than 30 years old
* having cardiac，hepatic or renal，peripheral vascular diseases
* refuse to enter our study or sign an written informed consent

Primary outcomes:
measure: Transient limb ischemia would change expression of several serum proteins in humans,indicating a humoral mechanism for its organ protection.
timeFrame: two years
Secondary outcomes:
measure: A questionnaire study of the acceptability of transient limb ischemia in healthy conscious subjects.
timeFrame: one year
Other outcomes:
Locations:
city: Guangzhou
country: China
facility: proteomics lab of Sun Yat-sen University
state: Guangdong
Study officials:
affiliation: Sixth Affiliated Hospital, Sun Yat-sen University
name: Jin S qing, Doctor
role: STUDY_DIRECTOR
References:
Clinical trial NCT01983800: AnaConDa Long Term Sedation Study
Official title: Use of Volatile Anesthetics for Long-Term Sedation In Critically Ill Patients
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Intubated Requiring Sedation for Greater Than 48 Hours
Keywords: Mechanical Ventilation
Volatile Sedation
Intravenous Sedation
Delirium
Lead sponsor: University Health Network, Toronto
Sponsor class: OTHER
First posted: 2013-11-14
Enrollment: 60
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: Heavy sedation or sleep is a common problem within the intensive care unit (ICU) using our standard intravenous medications. This commonly leads to confusion, low blood pressure, slow wake up and removal of the artificial breathing tube (extubation), which prolongs ICU stay. Using inhaled volatile anesthetic agents are likely to improve these patient outcomes. This unique project is the first North American study looking at using volatiles for patients who need longer-term ICU sedation. This project has excellent potential at lowering these complications and improving quality of care, which will lower patient ICU stay and healthcare costs.


Eligibility criteria: Inclusion Criteria:

* adult ICU patients expected to be ventilated \> 48 hours

Exclusion Criteria:

* age \< 18 years
* history of malignant hyperthermia
* propofol infusion syndrome
* evidence of raised intracranial pressure
* 6-month mortality risk from pre-existing condition \> 50%
* lack of commitment to maximal treatment
* pregnant
* NebulizedFlolan
* tidal volume \<350ml
* patients on one lung ventilation

Primary outcomes:
measure: atmospheric volatile concentration
timeFrame: daily
measure: Sedation
timeFrame: daily
measure: Feasibility
timeFrame: 2 years
measure: Education Tool
timeFrame: 2 years
measure: serum fluoride levels
timeFrame: every 2 days
Secondary outcomes:
Other outcomes:
Locations:
city: Ottawa
country: Canada
facility: Ottawa Heart Institute
state: Ontario
city: Toronto
country: Canada
facility: Toronto General Hospital, University Health Network
state: Ontario
Study officials:
affiliation: Toronto General Hospital, University Health Network
name: Angela Jerath, MD
role: PRINCIPAL_INVESTIGATOR
References:
citation: Jerath A, Ferguson ND, Steel A, Wijeysundera D, Macdonald J, Wasowicz M. The use of volatile anesthetic agents for long-term critical care sedation (VALTS): study protocol for a pilot randomized controlled trial. Trials. 2015 Dec 9;16:560. doi: 10.1186/s13063-015-1083-5.
Clinical trial NCT06481800: PMR Versus MLD on RLS and Sleep Quality in Hemodialysis Patients
Official title: Progressive Muscle Relaxation Versus Manual Lymphatic Drainage on Restless Leg Syndrome and Sleep Quality in Hemodialysis Patients
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Hemodialysis Complication
Lead sponsor: MTI University
Sponsor class: OTHER
First posted: 2024-07-01
Enrollment: 120
Sex: ALL
Minimum age (years): 35
Maximum age (years): 65
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Intervention model description: Randomized controlled trial. To assign patients to different treatment groups, a table of random numbers generated by a computer will be used. Patients will be allocated randomly into three groups using this method
Primary purpose: TREATMENT

Brief summary: Progressive muscle relaxation versus manual lymphatic drainage on restless leg syndrome and sleep quality in hemodialysis patients

Detailed description: Restless legs syndrome (RLS) is a sensory motor disturbance with features of both neurologic and sleeps disorders. The patients complain of strong, irresistible urge to move the legs, often accompanied by uncomfortable sensations deeply in the legs. Poor sleep quality affects many hemodialysis patients and can potentially predict their morbidity, mortality, quality of life and pattern of medication use. Progressive muscle relaxation (PMR) is one way to improve physical work capacity and reduce functional limitations. Manual lymphatic drainage (MLD) is a traditional therapy in which the hands work on the tissues of the body, including tuina, acupressure, and the likes. It is beneficial to the well-being of patients both physically and mentally

Eligibility criteria: Inclusion Criteria:

* Male and female adults ranging from 35- 65 years old.
* Able to communicate verbally and agree to participate in the study.
* On maintenance arteriovenous fistula (AVF) hemodialysis 3 times weekly.
* None of the research participants had a lower extremity dialysis graft, and they were all taking medication to maintain their health.
* Prior to the study procedure, all patients underwent a nephrologist assessment
* All patients had good compliance with their dialysis treatment (not missing more than 2 dialysis sessions in the prior 3 months

Exclusion Criteria:

* Peripheral neuropathy or vascular diseases of the lower limbs.
* Skin diseases including acute psoriasis or eczema.
* Recent fractures or lower limbs surgeries.
* Feet injuries including severe muscle weakness, bruises, ulcers, Open wounds or recent burns

Primary outcomes:
measure: International restless legs syndrome rating scale (IRLS)
timeFrame: base line and 12 weeks.
measure: Pittsburgh Sleep Quality Index (PSQI)
timeFrame: base line and 12 weeks
Secondary outcomes:
measure: Leg cramps severity scale
timeFrame: base line and 12 weeks
measure: Patient Health Questionnaire (PHQ-9)
timeFrame: base line and 12 weeks
Other outcomes:
Locations:
city: Cairo
country: Egypt
facility: Ahmed Mohamed Ahmed Abdelhady
Study officials:
References:
Clinical trial NCT00001400: Outpatient Evaluation of Patients With Known or Suspected Heart Disease
Official title: Outpatient Evaluation of Patients With Known or Suspected Heart Disease (Screening Protocol)
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Heart Disease
Keywords: Heart Disease
Screening
Follow-Up
Lead sponsor: National Institutes of Health Clinical Center (CC)
Sponsor class: NIH
First posted: 1999-11-04
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no

Brief summary: This study is designed to screen patients with heart diseases who may qualify to participate in other research studies being conducted by the Cardiology Branch of the National Heart, Lung, and Blood Institute (NHLBI).

Patients participating in this research study will be seen on an outpatient basis and undergo a general medical evaluation, including blood tests, urine, examination, chest x-ray and electrocardiogram (EKG). In addition, patients may be asked to have an echocardiogram (ultrasound scan of the heart) and to perform an exercise stress test.

Patients participating in this study will not receive any investigational treatments.

Detailed description: This protocol permits outpatient screening of patients with cardiovascular diseases who may be candidates for participation in current Cardiology Branch research protocols. No investigational treatments will be administered on this protocol.

Eligibility criteria: Must not be enrolled in an active Cardiology Branch research protocol.

The patient must be of scientific interest to the Cardiology Branch, as determined by the investigator.

Patient is being screened for participation in an active protocol.

Primary outcomes:
Secondary outcomes:
Other outcomes:
Locations:
city: Bethesda
country: United States
facility: National Heart, Lung and Blood Institute (NHLBI)
state: Maryland
Study officials:
References: