Clinical trial NCT04423718: Study of the Effects of High Dose Aflibercept Injected Into the Eye of Patients With an Age-related Disorder That Causes Loss of Vision Due to Growth of Abnormal Blood Vessels at the Back of the Eye
Official title: Randomized, Double-Masked, Active-Controlled, Phase 3 Study of the Efficacy and Safety of High Dose Aflibercept in Patients With Neovascular Age-Related Macular Degeneration
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE3
Conditions: Neovascular Age-Related Macular Degeneration
Keywords: nAMD
Lead sponsor: Bayer
Sponsor class: INDUSTRY
Collaborators: name: Regeneron Pharmaceuticals
First posted: 2020-06-09
Enrollment: 1011
Sex: ALL
Minimum age (years): 50
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: In this study researchers want to learn more about changes in visual acuity (clarity of vision) with a high dose treatment with Aflibercept (Eylea) in patients suffering from neovascular age-related macular degeneration (nAMD). Neovascular AMD is an eye disease that causes blurred vision or a blind spot due to abnormal blood vessels that leak fluid or blood into the light sensitive lining inside the eye (retina). The fluid buildup causes the central part of the retina (macula) responsible for sharp, straight-ahead vision to swell and thicken (edema), which distorts vision.


Eligibility criteria: Inclusion Criteria:

* Active subfoveal CNV secondary to nAMD, including juxtafoveal lesions that affect the fovea as assessed in the study eye.
* Total area of CNV (including both classic and occult components) must comprise greater than 50% of the total lesion area in the study eye.
* BCVA ETDRS letter score of 78 to 24 (corresponding to a Snellen equivalent of approximately 20/32 to 20/320) in the study eye.
* Decrease in BCVA determined to be primarily the result of nAMD in the study eye.
* Presence of IRF and/or SRF affecting the central subfield of the study eye on OCT.
* Contraceptive use by men or women should be consistent with local regulations regarding the methods of highly effective contraception for those participating in clinical studies.
* Other protocol-specified inclusion criteria.

Additional inclusion criteria for Year 3:

* At least one BCVA value and one central subfield retinal thickness (CST) value from measurements at one of the following visits: Visit 24 (Week 84), Visit 25 (Week 88) or Visit 26 (Week 92).
* Participant is enrolled at a site that participates in the extension period.

Exclusion Criteria:

* Causes of CNV other than nAMD in the study eye.
* Scar, fibrosis, or atrophy involving the central subfield in the study eye.
* Presence of retinal pigment epithelial tears or rips involving the central subfield in the study eye.
* Uncontrolled glaucoma (defined as IOP \>25 mmHg despite treatment with anti-glaucoma medication) in the study eye.
* History of idiopathic or autoimmune uveitis in the study eye.
* Myopia of a spherical equivalent of at least 8 diopters in the study eye prior to any refractive or cataract surgery.
* History or clinical evidence of diabetic retinopathy, diabetic macular edema, or any retinal vascular disease other than nAMD in either eye.
* Evidence of extraocular or periocular infection or inflammation (including infectious blepharitis, keratitis, scleritis, or conjunctivitis) in either eye at the time of screening/randomization.
* Uncontrolled blood pressure (defined as systolic \>160 mmHg or diastolic \>95 mmHg).
* Any prior or concomitant ocular (in the study eye) or systemic treatment (with an investigational or approved, anti-VEGF or other agent) or surgery for nAMD, except dietary supplements or vitamins.
* Other protocol-specified exclusion criteria

Primary outcomes:
measure: Change From Baseline in BCVA Measured by the ETDRS Letter Score at Week 48
timeFrame: At baseline and Week 48
Secondary outcomes:
measure: Change From Baseline in BCVA Measured by the ETDRS Letter Score at Week 60
timeFrame: At baseline and Week 60
measure: Percentage of Participants With no Intraretinal Fluid (IRF) and no Subretinal Fluid (SRF) in Central Subfield at Week 16
timeFrame: At Week 16
measure: Percentage of Participants Gaining at Least 15 Letters in BCVA From Baseline at Week 48
timeFrame: At baseline and Week 48
measure: Percentage of Participants Achieving an ETDRS Letter Score of at Least 69 (Approximate 20/40 Snellen Equivalent) at Week 48
timeFrame: At Week 48
measure: Change in Choroidal Neovascularization (CNV) Size From Baseline to Week 48
timeFrame: At baseline and Week 48
measure: Change in Total Lesion Area From Baseline to Week 48
timeFrame: At baseline and Week 48
measure: Percentage of Participants With no Intraretinal Fluid (IRF) and no Subretinal Fluid (SRF) in the Center Subfield at Week 48
timeFrame: At Week 48
measure: Change From Baseline in Central Subfield Retinal Thickness (CST) at Week 48
timeFrame: At baseline and Week 48
measure: Change From Baseline in National Eye Institute Visual Functioning Questionnaire-25 (NEI-VFQ-25) Total Score at Week 48
timeFrame: At baseline and Week 48
measure: Number of Participants With Treatment-emergent Adverse Events (TEAEs) and Serious AEs (SAEs)
timeFrame: Up to 156 weeks
measure: Systemic Exposure to Aflibercept as Assessed by Plasma Concentrations of Free, Adjusted Bound and Total Aflibercept From Baseline Through Week 48
timeFrame: Up to Week 48
measure: Assessment of Immunogenicity to Aflibercept by Measuring the Incidence of Treatment-emergent Anti-drug Antibodies (ADA) Response Through End of Masked Study
timeFrame: Up to week 96
Other outcomes:
Locations:
city: Phoenix
country: United States
facility: Arizona Retina and Vitreous Consultants - North Phoenix
state: Arizona
city: Fullerton
country: United States
facility: Retina Consultants of Orange County
state: California
city: La Jolla
country: United States
facility: University of California San Diego (UCSD)
state: California
city: Mountain View
country: United States
facility: Northern California Retina-Vitreous Associates
state: California
city: Pasadena
country: United States
facility: California Eye Specialists Medical Group, Inc.
state: California
city: Poway
country: United States
facility: Retina Consultants San Diego
state: California
city: Redlands
country: United States
facility: Retina Consultants of Southern California
state: California
city: Riverside
country: United States
facility: Kaiser Permanente Riverside Medical Center
state: California
city: Colorado Springs
country: United States
facility: Retina Consultants of Southern Colorado, PC
state: Colorado
city: New London
country: United States
facility: New England Retina Associates
state: Connecticut
city: Deerfield Beach
country: United States
facility: Rand Eye Institute
state: Florida
city: Fort Lauderdale
country: United States
facility: Retina Group of Florida - Fort Lauderdale
state: Florida
city: Gainesville
country: United States
facility: Vitreo Retinal Associates PA - The Millennium Center Location
state: Florida
city: Jacksonville
country: United States
facility: Florida Retina Institute- Jacksonville Oak
state: Florida
city: Melbourne
country: United States
facility: Florida Eye Associates
state: Florida
city: Miami
country: United States
facility: Retina Macula Specialists Of Miami
state: Florida
city: Orlando
country: United States
facility: Florida Retina Institute
state: Florida
city: Pensacola
country: United States
facility: Retina Specialists
state: Florida
city: Saint Petersburg
country: United States
facility: Retina Vitreous Associates of Florida - Saint Petersburg
state: Florida
city: Tallahassee
country: United States
facility: Southern Vitreoretinal Associates, P.L. - Tallahassee
state: Florida
city: 'Aiea
country: United States
facility: Retina Consultants of Hawaii
state: Hawaii
city: Elmhurst
country: United States
facility: Retina Associates IL
state: Illinois
city: Oak Forest
country: United States
facility: University Retina and Macula Associates
state: Illinois
city: West Des Moines
country: United States
facility: Wolfe Eye Clinic - Des Moines
state: Iowa
city: Baltimore
country: United States
facility: Retina Care Center
state: Maryland
city: Boston
country: United States
facility: Ophthalmic Consultants of Boston (OCB) - Boston
state: Massachusetts
city: Edina
country: United States
facility: Vitreo Retinal Surgery PA - Edina
state: Minnesota
city: Las Vegas
country: United States
facility: Retina Consultants of Nevada
state: Nevada
city: Bloomfield
country: United States
facility: Retina Center of New Jersey
state: New Jersey
city: Edison
country: United States
facility: NJ Retina - Edison Office
state: New Jersey
city: Albuquerque
country: United States
facility: Eye Associates of New Mexico
state: New Mexico
city: Great Neck
country: United States
facility: Long Island Vitreoretinal Consultants
state: New York
city: Hauppauge
country: United States
facility: Long Island Vitreoretinal Consultants - Hauppauge
state: New York
city: Lynbrook
country: United States
facility: Ophthalmic Consultants of Long Island
state: New York
city: Troy
country: United States
facility: Ophthalmic Consultants of the Capital Region
state: New York
city: Winston-Salem
country: United States
facility: Wake Forest Baptist Health
state: North Carolina
city: Dublin
country: United States
facility: Midwest Retina - Main Office
state: Ohio
city: Portland
country: United States
facility: Retina Northwest, PC - Opthalmology
state: Oregon
city: Salem
country: United States
facility: Retina Consultants, LLC
state: Oregon
city: Bethlehem
country: United States
facility: Mid Atlantic Retina
state: Pennsylvania
city: Erie
country: United States
facility: Erie Retinal Surgery, Inc.
state: Pennsylvania
city: Kingston
country: United States
facility: Eye Care Specialists
state: Pennsylvania
city: Charleston
country: United States
facility: Charleston Neuroscience Institute - Charleston
state: South Carolina
city: West Columbia
country: United States
facility: Palmetto Retina Center (PRC)- West Columbia Retina Center
state: South Carolina
city: Rapid City
country: United States
facility: Black Hills Regional Eye Institute
state: South Dakota
city: Memphis
country: United States
facility: Charles Retina Institute
state: Tennessee
city: Nashville
country: United States
facility: Vanderbilt University Medical School
state: Tennessee
city: Austin
country: United States
facility: Austin Retina Associates
state: Texas
city: Fort Worth
country: United States
facility: Texas Retina Associates
state: Texas
city: San Antonio
country: United States
facility: Medical Center Ophthalmology Associates
state: Texas
city: San Antonio
country: United States
facility: Retinal Consultants of Texas - San Antonio
state: Texas
city: The Woodlands
country: United States
facility: Retina Consultants of Texas (Retina Consultants of Houston) - Texas Medical Center
state: Texas
city: The Woodlands
country: United States
facility: Retina Consultants of Texas - The Woodlands
state: Texas
city: Burlington
country: United States
facility: The University of Vermont Medical Center (Fletcher Allen Health Care) - Main Campus
state: Vermont
city: Spokane
country: United States
facility: Spokane Eye Clinical Research
state: Washington
city: Morgantown
country: United States
facility: West Virginia University
state: West Virginia
city: Madison
country: United States
facility: University of Wisconsin - Madison
state: Wisconsin
city: Buenos Aires
country: Argentina
facility: Organizacion Medica de Investigacion (OMI)
state: Ciudad Auton. De Buenos Aires
city: Buenos Aires
country: Argentina
facility: OFTALMOS, Instituto Oftalmologico de Alta Complejidad
state: Ciudad Auton. De Buenos Aires
city: Albury
country: Australia
facility: Eyeclinic Albury Wodonga
state: New South Wales
city: Sydney
country: Australia
facility: Sydney Retina Clinic
state: New South Wales
city: Westmead
country: Australia
facility: Westmead Hospital
state: New South Wales
city: Hobart
country: Australia
facility: Hobart Eye Surgeons
state: Tasmania
city: Parramatta
country: Australia
facility: Marsden Eye Surgery Center
city: Klagenfurt
country: Austria
facility: Klinikum Klagenfurt am Wörthersee
state: Kärnten
city: Linz
country: Austria
facility: Kepler Universitätsklinikum Campus III
state: Oberösterreich
city: Linz
country: Austria
facility: Konventhospital Barmherzige Brüder Linz
state: Oberösterreich
city: Graz
country: Austria
facility: Medizinische Universität Graz
state: Steiermark
city: Wien
country: Austria
facility: Hanusch-Krankenhaus Wien
city: Sofia
country: Bulgaria
facility: SEHAT Pentagram
city: Sofia
country: Bulgaria
facility: Spec. Hosp. for Active Treatment for Eye Diseases Zrenie
city: Sofia
country: Bulgaria
facility: University Multiprofile Hospital For Active Treatment 'Alexandrovska' EAD
city: Sofia
country: Bulgaria
facility: Multiprofile Hospital for Active Treatment Sveta Sofia | Internal Diseases Department
city: Sofia
country: Bulgaria
facility: Specialized Hospital For Active Treatment of Eye Diseases Zora
city: Varna
country: Bulgaria
facility: Sveta Petka Eye Hospital
city: London
country: Canada
facility: St.Joseph's Health Care-London
state: Ontario
city: Toronto
country: Canada
facility: Toronto Retina Institute
state: Ontario
city: Boisbriand
country: Canada
facility: Institut de l'Oeil des Laurentides
state: Quebec
city: Hefei
country: China
facility: The Second Hospital of Anhui medical university
state: Anhui
city: Beijing
country: China
facility: Beijing Tongren Hospital, Capital Medical University (East)
state: Dongcheng District
city: Fuzhou
country: China
facility: The 1st Affiliated Hospital Fujian Medical University
state: Fujian
city: Guangzhou
country: China
facility: Guangzhou Aier Eye Hospital
state: Guangdong
city: Hebei
country: China
facility: Hebei eye hospital
state: Hebei
city: Shijiazhuang
country: China
facility: Shijiazhuang General Hospital
state: Hebei
city: Henan
country: China
facility: Henan Provincial Eye Hospital
state: Henan
city: Wuhan
country: China
facility: Tongji Hosp. of Tongji Med Coll, Huazhong Uni of Sci & Tech.
state: Hubei
city: Wuhan
country: China
facility: Union Hospt Tongji Medical Colleg. Huazhong univ. Scien&Tech
state: Hubei
city: Xuzhou
country: China
facility: The First People's Hospital of Xuzhou
state: Jiangsu
city: Nanchang
country: China
facility: Jiangxi Provincial People's Hospital
state: Jiangxi
city: Nanchang
country: China
facility: The First Affiliated Hospital of NanChang University
state: Jiangxi
city: Changchun
country: China
facility: Eye Center of the second Bethune Hospital, jinlin University
state: Jilin
city: Tonghua
country: China
facility: Tonghua Central Hospital
state: Jilin
city: Shenyang
country: China
facility: Shenyang He Eye Specialist Hospital
state: Liaoning
city: Ningxia
country: China
facility: People's Hospital of Ningxia Hui Autonomous Region - Opthalmology
state: Ningxia
city: Xi'an
country: China
facility: The First Affiliated Hospital of Xi'an Jiaotong University
state: Shanxi
city: Chengdu
country: China
facility: Aier Eye Hospital (Chengdu)
state: Sichuan
city: Urumqi
country: China
facility: The First Affiliated Hospital of Xinjiang Medical University
state: Xinjiang
city: Hangzhou
country: China
facility: The 1st Affiliated Hospital of Zhejiang University
state: Zhejiang
city: Hangzhou
country: China
facility: ZheJiang Provincial People's Hospital
state: Zhejiang
city: Wenzhou
country: China
facility: The Affiliated Eye Hospital of Wenzhou Medical College
state: Zhejiang
city: Beijing
country: China
facility: Beijing Aier Intech Eye Hospital
city: Beijing
country: China
facility: Peking University People's Hospital
city: Beijing
country: China
facility: Beijing Hospital
city: Chongqing
country: China
facility: Chongqing Aier Ophthalmology Hospital
city: Shanghai
country: China
facility: Shanghai Tongji Hospital of Tongji University
city: Shanghai
country: China
facility: Shanghai General Hospital
city: Tianjin
country: China
facility: Tianjin Medical University General Hospital
city: Tianjin
country: China
facility: Tianjin Eye Hospital
city: Tianjin
country: China
facility: Tianjin Medical University Eye Hospital
city: Hradec Kralove
country: Czechia
facility: Fakultni Nemocnice Hradec Kralove
city: Ostrava
country: Czechia
facility: Fakultni nemocnice Ostrava
city: Plzen-Lochotin
country: Czechia
facility: Fakultni nemocnice Plzen - Lochotin
city: Prague
country: Czechia
facility: Charles University in Prague
city: Praha 10
country: Czechia
facility: Fakultni nemocnice Kralovske Vinohrady
city: Praha 4
country: Czechia
facility: Lexum a.s., Evropska ocni klinika
city: Praha 5
country: Czechia
facility: AXON Clinical s.r.o.
city: Tallinn
country: Estonia
facility: East Tallinn Central Hospital
city: Tartu
country: Estonia
facility: Tartu University Hospital
city: Marseille
country: France
facility: Centre d'Ophtalmologie - Paradis-Monticelli
city: Paris
country: France
facility: Hôpital Lariboisière - Paris
city: Saint-Cyr-Sur-Loire
country: France
facility: Centre ophtalmologique Saint-Exupéry
city: Kutaisi
country: Georgia
facility: LTD "Clinic LJ" - Opthalmology
city: Tbilisi
country: Georgia
facility: JSC "Evex Hospitals'
city: Tbilisi
country: Georgia
facility: LTD "Innova"
city: Tbilisi
country: Georgia
facility: LTD "Chichua Medical Center MZERA"
city: Budapest
country: Hungary
facility: Budapest Retina Associates
city: Szeged
country: Hungary
facility: Szent-Gyorgyi Albert Orvostudomanyi Egyetem
city: Haifa
country: Israel
facility: Rambam Health Corporation
city: Haifa
country: Israel
facility: Lady Davis Carmel Medical Center
city: Jerusalem
country: Israel
facility: Hadassah Hebrew University Hospital Ein Kerem
city: Kfar Saba
country: Israel
facility: Meir Medical Center
city: Ramat Gan
country: Israel
facility: Chaim Sheba Medical Center
city: Rehovot
country: Israel
facility: Kaplan Medical Center
city: Tel Aviv
country: Israel
facility: Assuta Medical Centers - HaShalom
city: Roma
country: Italy
facility: Fondazione PTV Policlinico Tor Vergata
state: Lazio
city: Roma
country: Italy
facility: Fondazione Policlinico Universitario Agostino Gemelli IRCCS
state: Lazio
city: Roma
country: Italy
facility: IRCCS Fondazione G.B. Bietti Studio e Ricerca in Otalmologia
state: Lazio
city: Milano
country: Italy
facility: ASST Fatebenefratelli Sacco
state: Lombardia
city: Milano
country: Italy
facility: Ospedale San Raffaele s.r.l. - Oculistica
state: Lombardia
city: Cagliari
country: Italy
facility: A.O.U. di Cagliari
state: Sardegna
city: Perugia
country: Italy
facility: A.O. di Perugia
state: Umbria
city: Ichinomiya
country: Japan
facility: Daiyukai Daiichi Hospital
state: Aichi
city: Nagakute
country: Japan
facility: Aichi Medical University Hospital
state: Aichi
city: Nagoya
country: Japan
facility: Nagoya University Hospital
state: Aichi
city: Nagoya
country: Japan
facility: Nagoya City University Hospital
state: Aichi
city: Kitakyushu
country: Japan
facility: Kokura Memorial Hospital
state: Fukuoka
city: Kurume
country: Japan
facility: Kurume University Hospital
state: Fukuoka
city: Koriyama
country: Japan
facility: Southern Tohoku Eye Clinic
state: Fukushima
city: Maebashi
country: Japan
facility: Gunma University Hospital
state: Gunma
city: Sapporo
country: Japan
facility: Sapporo City General Hospital
state: Hokkaido
city: Sapporo
country: Japan
facility: KKR Sapporo Medical Center
state: Hokkaido
city: Amagasaki
country: Japan
facility: Hyogo Prefectural Amagasaki General Medical Center
state: Hyogo
city: Kobe
country: Japan
facility: Kobe University Hospital
state: Hyogo
city: Mito
country: Japan
facility: Kozawa Eye Hospital and Diabetes Center
state: Ibaraki
city: Kahoku-gun
country: Japan
facility: Kanazawa Medical University Hospital
state: Ishikawa
city: Kanazawa
country: Japan
facility: Kanazawa University Hospital
state: Ishikawa
city: Kita-gun
country: Japan
facility: Kagawa University Hospital
state: Kagawa
city: Kawasaki
country: Japan
facility: Medical corporation Eiwakai Dannoue Ophthalmology clinic
state: Kanagawa
city: Kawasaki
country: Japan
facility: St. Marianna University Hospital
state: Kanagawa
city: Yamato
country: Japan
facility: Otakeganka Tsukimino Clinic
state: Kanagawa
city: Tsu
country: Japan
facility: Mie University Hospital
state: Mie
city: Matsumoto
country: Japan
facility: Shinshu University Hospital
state: Nagano
city: Kashihara
country: Japan
facility: Nara Medical University Hospital
state: Nara
city: Yufu
country: Japan
facility: Oita University Hospital
state: Oita
city: Kurashiki
country: Japan
facility: Kurashiki Medical Center
state: Okayama
city: Okayama-city
country: Japan
facility: Okayama University Hospital
state: Okayama
city: Nakagami
country: Japan
facility: University of the Ryukyus Hospital
state: Okinawa
city: Hirakata
country: Japan
facility: Kansai Medical University Hospital
state: Osaka
city: Moriguchi
country: Japan
facility: Kansai Medical University Medical Center
state: Osaka
city: Osakasayama-shi
country: Japan
facility: Kindai University Hospital
state: Osaka
city: Bunkyo-ku
country: Japan
facility: The University of Tokyo Hospital
state: Tokyo
city: Chuoku
country: Japan
facility: St.Luke's International Hospital
state: Tokyo
city: Edogawa-ku
country: Japan
facility: Nishikasai Inouye Eye Hospital
state: Tokyo
city: Hachioji
country: Japan
facility: Tokyo Medical University Hachioji Medical Center
state: Tokyo
city: Itabashi-ku
country: Japan
facility: Tokiwadai Muranaka Eye Clinic
state: Tokyo
city: Meguro-ku
country: Japan
facility: National Hospital Organization Tokyo Medical Center
state: Tokyo
city: Shinjuku-ku
country: Japan
facility: Keio University Hospital
state: Tokyo
city: Shinjuku-ku
country: Japan
facility: Tokyo Women's Medical University Hospital
state: Tokyo
city: Ube
country: Japan
facility: Yamaguchi University Hospital
state: Yamaguchi
city: Chuo
country: Japan
facility: University of Yamanashi Hospital
state: Yamanashi
city: Akita
country: Japan
facility: Akita University Hospital
city: Fukuoka
country: Japan
facility: Hayashi Eye Hospital
city: Fukushima
country: Japan
facility: Fukushima Medical University Hospital
city: Hiroshima
country: Japan
facility: Hiroshima University Hospital
city: Miyazaki
country: Japan
facility: University of Miyazaki Hospital
city: Nagasaki
country: Japan
facility: Japanese Red Cross Nagasaki Genbaku Hospital
city: Saitama
country: Japan
facility: Japanese Red Cross Saitama Hospital
city: Tokushima
country: Japan
facility: Tokushima University Hospital
city: Wakayama
country: Japan
facility: Japanese Red Cross Wakayama Medical center
city: Yamagata
country: Japan
facility: Yamagata University Hospital
city: Seoul
country: Korea, Republic of
facility: Nune Eye Hospital - Retina Center Ophthalmology
state: Gangnam-gu
city: Seongnam-si
country: Korea, Republic of
facility: Seoul National University Bundang Hospital
state: Gyeonggido
city: Busan
country: Korea, Republic of
facility: Pusan National University Hospital
city: Busan
country: Korea, Republic of
facility: Inje University Haeundae Paik Hospital
city: Seoul
country: Korea, Republic of
facility: Seoul National University Hospital (b)
city: Seoul
country: Korea, Republic of
facility: Asan Medical Center
city: Seoul
country: Korea, Republic of
facility: Samsung Medical Center
city: Riga
country: Latvia
facility: Department of Ophthalmology
city: Riga
country: Latvia
facility: Latvian American Eye Center
city: Riga
country: Latvia
facility: Riga East Clinical University Hospital "Gailezers"
city: Kaunas
country: Lithuania
facility: Hospital of LT University of Health Sciences Kaunas Clinics
city: Klaipeda
country: Lithuania
facility: PI Klaipedos University Hospital
city: Vilnius
country: Lithuania
facility: Vilnius University Hospital Santaros Klinikos
city: Lisbon
country: Portugal
facility: ALM Oftalmolaser - Oftalmologia Medica e Cirurgica
state: Lisboa
city: Coimbra
country: Portugal
facility: AIBILI
city: Coimbra
country: Portugal
facility: Espaco Medico de Coimbra
city: Porto
country: Portugal
facility: Centro Hospitalar Universitario do Porto
city: Porto
country: Portugal
facility: Centro Hospitalar Vila Nova de Gaia e Espinho | Unit 1 - Clinical Research Center
city: Moscow
country: Russian Federation
facility: Scientific Research Institution of Ophthalmic Diseases
city: Moscow
country: Russian Federation
facility: FBSI IRTC Eye Microsurgery n.a. acad. S.N. Fyodorov
city: Belgrade
country: Serbia
facility: Clinical Center of Serbia
city: Belgrade
country: Serbia
facility: Clinical hospital center Zvezdara
city: Novi Sad
country: Serbia
facility: Klinicki centar Vojvodine
city: Singapore
country: Singapore
facility: National University Hospital
city: Singapore
country: Singapore
facility: Singapore National Eye Centre
city: Nitra
country: Slovakia
facility: Fakultna nemocnica Nitra
city: Trebisov
country: Slovakia
facility: Nemocnica s Poliklinikou Trebisov, Svet zdravia a.s.
city: Trencin
country: Slovakia
facility: Fakultna nemocnica Trencin
city: Zilina
country: Slovakia
facility: Fakultna nemocnica s poliklinikou Zilina
city: Santiago de Compostela
country: Spain
facility: Instituto Oftalmológico Francisco Gomez Ulla
state: A Coruña
city: Barcelona
country: Spain
facility: Hospital Clínic i Provincial de Barcelona
city: Barcelona
country: Spain
facility: Hospital de la Santa Creu i Sant Pau | Gynecology Department
city: Córdoba
country: Spain
facility: Hospital Reina Sofía
city: Valencia
country: Spain
facility: Hospital General Universitario de Valencia
city: Valencia
country: Spain
facility: La Fe University and Polytechnic Hospital | Nephrology Department
city: Zaragoza
country: Spain
facility: Hospital Miguel Servet
city: Lausanne
country: Switzerland
facility: RétinElysée
state: Vaud
city: Bern
country: Switzerland
facility: Berner Augenklinik am Lindenhofspital
city: Zürich
country: Switzerland
facility: Stadtspital Triemli
city: Taipei
country: Taiwan
facility: Shin Kong Wu Ho-Su Memorial Hospital
city: Taipei
country: Taiwan
facility: Taipei Veterans General Hospital
city: Taoyuan
country: Taiwan
facility: Chang Gung Memorial Hospital at Linkou
city: Kropyvnytskyi
country: Ukraine
facility: Private enterprise private production company " Acinus"
city: Kyiv
country: Ukraine
facility: Centralna Polyclinica MVS Ukraiiny
city: Poltava
country: Ukraine
facility: Poltava Regional Clinical Hospital n.a. M.V. Skliphosovskyi
Study officials:
References: