louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT01770847: Arterial Stiffness in Chronic Kidney Disease
Official title: Diurnal Variations in Arterial Stiffness in Patients With Chronic Kidney Disease and Healthy Age Matched Controls
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Chronic Kidney Disease
Lead sponsor: University of Edinburgh
Sponsor class: OTHER
First posted: 2013-01-18
Enrollment: 50
Sex: ALL
Minimum age (years): 18
Maximum age (years): 79
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: CASE_CONTROL
Time perspective: CROSS_SECTIONAL
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Potential patients will be identified from renal clinics at the Royal Infirmary and Western General Hospital. Suitable participants will initially be identified by a member of the direct healthcare team.

Healthy volunteers will be indentified through the Clinical Research Centre community database and poster advertising at the University of Edinburgh.

Brief summary: Diurnal variations in the cardiovascular system apparent in healthy individuals, are different in chronic kidney disease patients. Therefore, diurnal variations in arterial stiffness may also differ in chronic kidney disease patients. This study aims to identify and evaluate diurnal variations in arterial stiffness in chronic kidney disease patients and compare them to those in age matched healthy controls.


Eligibility criteria: Inclusion Criteria:

* Systolic blood pressure \<160 whether or not on antihypertensive medication
* diastolic blood pressure \<100mmHg whether or not on antihypertensive medication
* Chronic kidney disease stage 2-5

Exclusion Criteria:

* Systolic blood pressure ≥160mmHg
* Diastolic blood pressure ≥100mmhg
* Significant comorbidity (investigator opinion but to include alcoholism and terminal illness)

Primary outcomes:
measure: Diurnal variations in arterial stiffness
timeFrame: Over one 26 hour period arterial stiffness measurements will be obtained every 30 minutes from 7am to 12am and every 60 minutes from 12am to 7am
Secondary outcomes:
measure: Diurnal variations in aortic and brachial blood pressure
timeFrame: Over one 26 hour period blood pressure measurements will be obtained every 30 minutes from 7am to 12am and every 60 minutes from 12am to 7am
measure: Relationship between changes in blood pressure and arterial stiffness
timeFrame: Over one 26 hour period
Other outcomes:
Locations:
city: Edinburgh
country: United Kingdom
facility: Clinical Research Centre, 2nd Floor Western General Hospital
Study officials:
affiliation: University of Edinburgh
name: David J Webb, MB BS MD DSc FRCP FRSE FMedSci
role: PRINCIPAL_INVESTIGATOR
References:
citation: Dhaun N, Moorhouse R, MacIntyre IM, Melville V, Oosthuyzen W, Kimmitt RA, Brown KE, Kennedy ED, Goddard J, Webb DJ. Diurnal variation in blood pressure and arterial stiffness in chronic kidney disease: the role of endothelin-1. Hypertension. 2014 Aug;64(2):296-304. doi: 10.1161/HYPERTENSIONAHA.114.03533.
Clinical trial NCT06613347: Clinical Study to Assess the Efficacy of Professional Tooth Whitening Maintenance System
Official title: Clinical Study to Assess the Efficacy of Professional Tooth Whitening Maintenance System of a Colgate Regimen
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Staining
Keywords: whitening
stains
perceptions
Lead sponsor: Colgate Palmolive
Sponsor class: INDUSTRY
First posted: 2024-09-25
Enrollment: 93
Sex: ALL
Minimum age (years): 18
Maximum age (years): 65
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: PREVENTION

Brief summary: Clinical study to assess the efficacy of professional tooth whitening maintenance system of a Colgate toothpaste containing 5% Hydrogen Peroxide with a stain-fighter mouthwash as compared to only the stainfighter mouthwash and a negative control toothpaste


Eligibility criteria: Inclusion Criteria:

* permanent natural teeth (6-11) (22-27)
* composite lobene =\>1
* Signed Informed Consent Form
* Male and female subjects aged 18-70 years, inclusive
* Good general health and good oral health based on the opinion of the study investigator
* All maxillary anterior teeth (teeth #6 through #11) must be present;\& mandibular anterior ( Teeth #22 through 27) must be present
* Availability for the duration of the study
* Minimum average Vita Extended Bleachedguide 3D-Master shade score of 17 ≥ or darker
* A minimum mean of 1.5 ≥ determined by the Interproximal Modified Lobene (IML) Stain Index
* Demonstrate a tendency to form stain in anterior teeth/ Have high staining habits ( coffee/ wine/ tea drinker)

Exclusion Criteria:

* allergies
* Presence of orthodontic appliances or any anterior tooth with a prosthetic crown or veneer
* Restorations on the tooth to be scored which may interfere with scoring procedures
* Obvious signs of periodontal disease, rampant caries, or any condition that the dental examiner considers exclusionary from the study
* Five or more carious lesions requiring immediate care
* Concurrent participation in another clinical study
* Self-reported pregnant and/or lactating women
* History of allergies to tooth whitening products, hydrogen peroxide, personal care consumer products, or their ingredients
* Have dentinal sensitivity
* Taking medication within a year which could alters natural tooth color or appearance,
* Have used Professional Whitening product within a year or had a dental prophylaxis ( professional dental cleaning) within 30 days prior to the start of the study

Primary outcomes:
measure: Tooth color assessment
timeFrame: Baseline
measure: Tooth color assessment
timeFrame: 4 weeks
measure: Tooth color assessment
timeFrame: 8 weeks
measure: Interproximal Modified Lobene Stain Index
timeFrame: Baseline
measure: Interproximal Modified Lobene Stain Index
timeFrame: 4 week
measure: Interproximal Modified Lobene Stain Index
timeFrame: 8 week
Secondary outcomes:
Other outcomes:
Locations:
city: Costa Mesa
country: United States
facility: FAR Oral and Systemic Health Consulting, Inc
state: California
Study officials:
References:
Clinical trial NCT04454047: Extracapsular Arthroscopic Treatment for Refractory Tennis Elbow--Mid-and-short Term Retrospective Study of 50 Cases
Official title: Extracapsular Arthroscopic Treatment for Refractory Tennis Elbow--Mid-and-short Term Retrospective Study of 50 Cases
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Tennis Elbow
Keywords: Refractory tennis elbow
Arthroscopy
Intracapsular method
Extracapsular method
Surgical technology
Lead sponsor: Peking University Third Hospital
Sponsor class: OTHER
First posted: 2020-07-01
Enrollment: 50
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Observational model: COHORT
Time perspective: RETROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: The quantitative data of 50 patients (20 men and 30 women) were reviewed. The minimum age was 35 years, and the maximum age was 55 years old, with an average of 44.6 years.

Brief summary: This study retrospectively analysed surgical outcomes of consecutive 50 cases to investigate the technical standard and clinical effect of extracapsular arthroscopic treatment for refractory tennis elbow.

Detailed description: To investigate the technical standard of extracapsular arthroscopic treatment for refractory tennis elbow. Consecutive 50 cases of refractory tennis elbow from 50 patients who underwent extracapsular arthroscopic surgery which performed independently by the same doctor from March 2012 to November 2016 was retrospectively analyzed. The key points of technical standard were summarized, including debridement, decortication and microfracture, suture under arthroscopy and postoperative cast fixation. Visual Analogue Scale(VAS), Mayo elbow performance score and Disability of Arm, Shoulder, and Hand outcome measure (DASH) were evaluated for postoperative results. The effects of various technical points were analyzed by rank sum test, independent sample t test, χ2 test and multiple logistic regression.

Eligibility criteria: Inclusion Criteria:

1. Diagnosis was refractory tennis elbow;
2. Standard extracapsular method was used for surgery.

Exclusion Criteria:

1. Patient had past history of joint infection, joint tuberculosis, or osteomyelitis, or the upper limb had undergone surgery within the past 6 months;
2. Diagnosis was combined with severe heart, brain, kidney, or another organ dysfunction;
3. Case was complicated with other serious elbow joint diseases or injuries;
4. Patient did not sign the informed consent form.

Primary outcomes:
measure: Mayo Elbow Performance Score
timeFrame: 24 months
measure: Visual Analog Scale
timeFrame: 24 months
measure: Disability of Arm, Shoulder and Hand score
timeFrame: 24 months
measure: Activity of Daily Life recovery time
timeFrame: 24 months
Secondary outcomes:
Other outcomes:
Locations:
city: Beijing
country: China
facility: Peking Univerisity Third Hospital
state: Beijing
Study officials:
References:
Clinical trial NCT06674447: Awareness Among PT Regarding Sensory Integration Therapy on CP Population
Official title: Awareness Among Physical Therapists Of Baluchistan Regarding Effectiveness Of Sensory Integration Therapy On Cerebral Palsy Population
Study type: OBSERVATIONAL
Overall status: RECRUITING
Conditions: Sensory Integration Disorder (Disorder)
Keywords: Cerebral Palsy
sensory integration disorder
Lead sponsor: Riphah International University
Sponsor class: OTHER
First posted: 2024-11-05
Enrollment: 200
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Observational model: OTHER
Time perspective: CROSS_SECTIONAL
Sampling method: NON_PROBABILITY_SAMPLE
Study population: The Physical therapists of Baluchistan, that are exclusively practising in various areas of Baluchistan.

Brief summary: The study is to interrogate the awareness level of physiotherapists that are working in the region of Baluchistan, to access weather know about sensory integration therapy or they use it for the patients of cerebral palsy in their treatment plan or not.

Detailed description: The study title is ''AWARENESS AMONG PHYSICAL THERAPISTS OF BALUCHISTAN REGARDING EFFECTIVENESS OF SENSORY INTEGRATION THERAPY ON CEREBRAL PALSY POPULATION.' it is a cross-sectional study that will be conducted in the province of Baluchistan, Pakistan. The data will be conducted by 200 physical therapists on a self designed tool, that will allows us to know about the awareness among the physical therapist of this particular region to know if they are using sensory integration therapy in the treatment plan of the children suffering from cerebral palsy to know weather the sensory issues are being addressed over there by this therapy or not. Another purpose of this study is to make the therapists aware about sensory integration therapy and its efficacy in treating sensory processing and sensory integration issues present in the children that are suffering from cerebral palsy. The data will be collected by the physical therapists that are currently working in various hospitals of Baluchistan located in different regions of the province.

Eligibility criteria: Inclusion Criteria: Physical therapists working in province of Baluchistan, specifically.

Exclusion Criteria: Physical therapists working in areas other than Baluchistan.

Primary outcomes:
measure: Survey tool awareness of PT,s about Sensory Integration therapy
timeFrame: 20 minutes
Secondary outcomes:
Other outcomes:
Locations:
city: Lahore
country: Pakistan
facility: Riphah International University
state: Punjab
Study officials:
affiliation: Riphah International University
name: AYESHA WAQAR, MS
role: PRINCIPAL_INVESTIGATOR
References:
citation: Hume K, Steinbrenner JR, Odom SL, Morin KL, Nowell SW, Tomaszewski B, Szendrey S, McIntyre NS, Yucesoy-Ozkan S, Savage MN. Evidence-Based Practices for Children, Youth, and Young Adults with Autism: Third Generation Review. J Autism Dev Disord. 2021 Nov;51(11):4013-4032. doi: 10.1007/s10803-020-04844-2. Epub 2021 Jan 15.
Clinical trial NCT05322447: High-dose L-Carnitine and Diaphragmatic Function Assessed by Ultrasonography in Patients With Respiratory Failure.
Official title: Effect of High-dose L-Carnitine Supplementation on Diaphragmatic Function Assessed by Ultrasonography in Critically Ill Patients With Respiratory Failure: a Randomized Clinical Trial
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE4
Conditions: Respiratory Failure
Lead sponsor: Ain Shams University
Sponsor class: OTHER
First posted: 2022-04-11
Enrollment: 60
Sex: ALL
Minimum age (years): 21
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: L-Carnitine supplementation has been shown to boost muscular performance in several studies. In hemodialysis patients with muscular weakness, fatigue, or cramps/aches, after L-carnitine treatment, about two-thirds of patients had at least some improvement in muscular symptoms . L-Carnitine was also found to improve the left ventricular ejection fraction (LVEF) in hemodialysis patients with cardiac morbidity who had significantly reduced LVEF in echocardiography before supplementation. Moreover, L-Carnitine has been shown to improve muscular function and exercise performance in athletes in several studies


Eligibility criteria: Inclusion Criteria:

* Age from 21 years old or greater
* Both genders have respiratory failure either of the primary medical origin or in the post-surgical course.
* Not in need of mechanical ventilation

Exclusion Criteria:

* Renal failure on regular dialysis
* Hypothyroidism
* Seizures
* End-stage liver disease
* Mechanical ventilation
* History or discovered allergy to L-carnitine, pivampicillin, and other pivalate-conjugated antibiotics.

Primary outcomes:
measure: Ultrasound diaphragmatic function
timeFrame: at days 7
Secondary outcomes:
Other outcomes:
Locations:
city: Cairo
country: Egypt
facility: Faculty of medicine
city: Cairo
country: Egypt
facility: Mona A Ammar
Study officials:
References:
Clinical trial NCT06133647: Demographics, Characteristics and Outcomes of Male Breast Cancer Patients at Methodist Health System
Official title: Demographics, Characteristics and Outcomes of Male Breast Cancer Patients at Methodist Health System
Study type: OBSERVATIONAL
Overall status: RECRUITING
Conditions: Ductal Carcinoma in Situ
Invasive Lobular Breast Carcinoma
Lead sponsor: Methodist Health System
Sponsor class: OTHER
First posted: 2023-11-15
Enrollment: 8
Sex: ALL
Minimum age (years): 18
Maximum age (years): 85
Standard ages: ADULT
OLDER_ADULT
Observational model: COHORT
Time perspective: RETROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: * ≥ 18 years of age
* Patients diagnosed with ductal carcinoma in situ or invasive lobular carcinoma of the breast

Brief summary: To determine the number of MBC cases as well as the demographics, characteristics, and outcomes of MBC patients at Methodist Health System (MHS).

Detailed description: Male breast cancer (MBC) is a rare disease without sufficient clinical data supporting the management and treatment. The treatment of MBC arises from data extrapolated from female breast cancer (FBC). MBC has higher mortality than FBC. Previous studies have suggested differences between MBC and FBC; however, treatments remain the same for both. Larger studies in MBC are needed to provide more clinical data to help guide treatment.

Eligibility criteria: Inclusion Criteria:

* • ≥ 18 years of age Patients diagnosed with ductal carcinoma in situ or invasive lobular carcinoma of the breast

Exclusion Criteria:

* 18 years of age

  * Prisoners
  * Pregnant or breastfeeding

Primary outcomes:
measure: Diagnosis Rates of patients with MBC and FBC
timeFrame: 13 years
measure: Recurrence rates of Patients with MBC and FBC
timeFrame: 13 years
measure: Duration of remission in Patients with MBC and FBC
timeFrame: 13 years
measure: The Overall Survival of patients with MBC and FBC after receiving treatment
timeFrame: 13 years
measure: Determine the complications of Treatment in patients with MBC and FBC
timeFrame: 13 years
Secondary outcomes:
Other outcomes:
Locations:
city: Dallas
country: United States
facility: Clinical Research Institute at Methodist Health System
state: Texas
city: Dallas
country: United States
facility: Clinical Research Institute at Methodist Health System
state: Texas
Study officials:
References:
Clinical trial NCT06409247: iExposure Intervention for Social Anxiety
Official title: Testing the Role of Attentional and Audio Vocal Mechanisms in a New Internet- Based Intervention for Social Anxiety: iExposure
Study type: INTERVENTIONAL
Overall status: RECRUITING
Phase: NA
Conditions: Social Anxiety
Lead sponsor: Palo Alto University
Sponsor class: OTHER
First posted: 2024-05-10
Enrollment: 390
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: Social anxiety (SA) is a highly prevalent mental health concern, thought to disproportionately affect youth with recent international estimates of more than 30% of individuals reporting clinically elevated symptoms. Despite the prevalence of SA, as few as one in five individuals receive care, due to limited access to evidence-based treatments. Additionally there has been a notable increase in social anxiety since the start of the COVID-19 pandemic. This proposal will use iExposure to develop a personalized mechanism-focused approach to optimizing treatment response for individuals with social anxiety by testing standard iExposure against two augmentations that incorporate distinct attention mechanisms (attention guidance and attention control).


Eligibility criteria: Inclusion Criteria:

* Age 18 or older
* Fluent in English
* Leibowitz Social Anxiety Scale \> 47 and endorses both social anxiety items on the Web Screening Questionnaire for Common Mental Disorders

Exclusion Criteria:

* Currently receiving CBT for Social Anxiety Disorder
* Significant visual impairment precluding engagement in the simulated teleconferencing interactions
* Unstable dose of psychotropic medications within 6 weeks prior to baseline assessment
* Current alcohol or substance use disorder
* Current or past bipolar disorder or psychosis

Primary outcomes:
measure: Liebowitz Social Anxiety Scale Self Report Version
timeFrame: 0 days
measure: Liebowitz Social Anxiety Scale Self Report Version
timeFrame: 15 days
measure: Liebowitz Social Anxiety Scale Self Report Version
timeFrame: 45 days
measure: Personal Report of Communication Apprehension (PRCA)
timeFrame: 0 days
measure: Personal Report of Communication Apprehension
timeFrame: 15 days
measure: Personal Report of Communication Apprehension
timeFrame: 45 days
Secondary outcomes:
measure: Center for Epidemiologic Studies Depression Scale - Revised
timeFrame: 0 days
measure: Center for Epidemiologic Studies Depression Scale - Revised
timeFrame: 15 days
measure: Center for Epidemiologic Studies Depression Scale - Revised
timeFrame: 45 days
Other outcomes:
Locations:
city: Palo Alto
country: United States
facility: Palo Alto University
state: California
Study officials:
References:
Clinical trial NCT01753947: Individualized Deliberate Practice on a Virtual Reality Simulator
Official title: Individualized Deliberate Practice on a Virtual Reality Simulator Improves Technical Performance of Surgical Novices in the Operating Room: A Randomized Controlled Trial
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Education
General Surgery
Lead sponsor: Unity Health Toronto
Sponsor class: OTHER
Collaborators: name: Royal College of Physicians and Surgeons of Canada
First posted: 2012-12-20
Enrollment: 16
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL

Brief summary: Training on simulated models in a surgical skills laboratory has been shown to improve technical performance in the operating room. Currently described simulation-based curricula consist of trainees practicing the same tasks until expert proficiency is reached. It has yet to be investigated whether individualized deliberate practice, where curricula tasks vary depending on prior levels of technical proficiency, would translate to the operating room.

This randomized controlled trial effectively demonstrates that deliberate practice on a virtual reality simulator results in an improvement in technical skills in a real clinical situation. This enhances the feasibility of implementing simulation-based curricula into residency training programs, and consequently has the potential to improve patient safety.


Eligibility criteria: Inclusion Criteria:

* post graduate year 1 and 2 surgical residents
* performed less than 10 laparoscopic cholecystectomies as the primary surgeon

Exclusion Criteria:

* n/a

Primary outcomes:
measure: Technical skills
timeFrame: 6 months
Secondary outcomes:
Other outcomes:
Locations:
city: Toronto
country: Canada
facility: University of Toronto
state: Ontario
Study officials:
References:
Clinical trial NCT02036047: The Effectiveness of an Exclusive Cold Snare Polypectomy Snare for the Removal of Diminutive Colorectal Polyps
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Diminutive Colorectal Polyp
Cold Snare Polypectomy
Polypectomy Snare
Complete Resection Rate
Postpolypectomy Bleeding
Lead sponsor: Showa Inan General Hospital
Sponsor class: OTHER
First posted: 2014-01-14
Enrollment: 80
Sex: ALL
Minimum age (years): 20
Maximum age (years): 90
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: SINGLE_GROUP
Primary purpose: TREATMENT

Brief summary: The use of an exclusive cold polypectomy snare enables a clean cut of diminutive colorectal polyps, resulting in an increase in the complete resection rate and a decrease in the adverse events.


Eligibility criteria: Inclusion Criteria:

* Patients with colorectal polyps up to 10 mm in diameter.

Exclusion Criteria:

* patients are less than 20 years old, pregnant, ASA class III and IV, allergic to propofol used or its components (soybeans or eggs), with poor bowel preparation, and with previous colorectal surgical resection.

Primary outcomes:
measure: Complete resection rate of colorectal polyps
timeFrame: 2 weeks
Secondary outcomes:
measure: Postpolypectomy bleeding
timeFrame: 2 weeks
Other outcomes:
measure: The procedure time
timeFrame: 1 day
Locations:
city: Komagane
country: Japan
facility: Showa Inan General Hospital
state: Nagano
Study officials:
References:
citation: Horiuchi A, Hosoi K, Kajiyama M, Tanaka N, Sano K, Graham DY. Prospective, randomized comparison of 2 methods of cold snare polypectomy for small colorectal polyps. Gastrointest Endosc. 2015 Oct;82(4):686-92. doi: 10.1016/j.gie.2015.02.012. Epub 2015 Apr 25.