Clinical trial NCT01930513: Exercise Capacity and Daily Physical Activity in Obese Subjects With Treated Obstructive Sleep Apnea
Official title: Exercise Capacity and Daily Physical Activity in Obese Subjects With Treated Obstructive Sleep Apnea
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Obstructive Sleep Apnea
Obesity
Keywords: Obesity
Obstructive Sleep Apnea
Exercise
Walking tests
Cardiopulmonary exercise tests
Physical activity
Lead sponsor: West Park Healthcare Centre
Sponsor class: OTHER
First posted: 2013-08-29
Enrollment: 16
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: Obstructive Sleep Apnea

Brief summary: Obesity is very common worldwide and breathing problems at night (obstructive sleep apnea, OSA) are common in obesity. Despite the best treatment, obesity and OSA are linked to early death from heart problems. They are also associated with lower levels of physical activity. Exercise strategies for weight loss, increasing physical activity and improving fitness are needed for obesity. In Obese individuals with OSA

1. The investigators will compare corridor walking tests compared to laboratory exercise tests. The null hypothesis is that the peak oxygen uptake achieved and the cardiopulmonary response during both the six-minute walk test and Incremental Shuttle Walk Test would not be different from that observed during an Incremental Treadmill Test.
2. The investigators will investigate whether cycling or walking uses more calories for the same intensity. We hypothesise that cycling (weight supported) will be endured for long.
3. The investigators will compare commonly used exercise tests with levels of daily physical activity.

The information from these three projects will help us set up the optimal exercise program for obese individuals.


Eligibility criteria: Inclusion Criteria:

* Obstructive Sleep Apnea
* Obesity BMI\>30
* Controlled on Continuous Positive Airway Pressure for three months

Exclusion Criteria:

* cardiac co-morbidity e.g ischaemic heart disease, chronic heart failure, valvular heart disease
* pulmonary co-morbidity
* neurological condition limiting the ability to perform walking or cycling
* orthopaedic condition limiting the ability to perform walking or cycling

Primary outcomes:
measure: Peak oxygen uptake (Peak VO2) measured at the end of the Incremental Shuttle Walk Test (ISWT)
timeFrame: All outcome measures will be performed within four weeks of each other
Secondary outcomes:
measure: Six minute walk test (6MWT)
timeFrame: Four weeks
measure: Incremental Treadmill Test (ITM)
timeFrame: Four weeks
measure: Incremental cycle test (ICE)
timeFrame: Four weeks
measure: Endurance cycle ergometer
timeFrame: Four weeks
measure: Endurance treadmill test
timeFrame: Four weeks
measure: Daily physical activity
timeFrame: Four weeks
Other outcomes:
Locations:
city: Toronto
country: Canada
facility: West Park Healthcare Centre
state: Ontario
Study officials:
affiliation: West Park Healthcare Centre
name: Roger S Goldstein, MBChB
role: PRINCIPAL_INVESTIGATOR
References:
citation: Evans RA, Dolmage TE, Robles PG, Goldstein RS, Brooks D. Do field walking tests produce similar cardiopulmonary demands to an incremental treadmill test in obese individuals with treated OSA? Chest. 2014 Jul;146(1):81-87. doi: 10.1378/chest.13-2060.