Clinical trial NCT05506852: Using Teleneuropsychology to Optimize Cognition in Healthy Aging: the Web-based Breakfast Game
Official title: Training Executive Control in Cognitively Healthy Aging: the Web-based Breakfast Game
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Healthy Aging
Keywords: cognition
cognitive training
non-pharmacological intervention
video game
cognitive enhancement
computer-based
teleneuropsychology
computerized
attention control
executive control
cognitive decline
multi-tasking
Lead sponsor: Columbia University
Sponsor class: OTHER
Collaborators: name: National Institute on Aging (NIA)
First posted: 2022-08-18
Enrollment: 38
Sex: ALL
Minimum age (years): 60
Maximum age (years): 75
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: Executive control processes involve initiate, coordinate, synchronize, and regulate elemental cognitive functions for the conduct of goal-directed behavior. The proposed research investigates whether exposure to a web-based training protocol designed to enhance executive control processes will improve cognitive performance in cognitively healthy older adults.

Detailed description: The proposed research investigates whether exposure to a web-based training protocol designed to enhance executive control / multi-tasking abilities will improve cognitive performance in healthy older adults. Cognitively normal adults aged 60-75 will be randomized into two experimental groups: 1) Web-based game with training strategy; 2) Web-based game without training strategy (Active Control). All participants (groups 1 and 2) will be instructed to play the complex, high-demand online game, Breakfast Game, for 14 one-hour sessions over 5 weeks.

Eligibility criteria: Inclusion Criteria:

* Age 60-75
* Willingness to adhere to training protocol
* Adequate English proficiency

Exclusion Criteria:

* Low test scores (below 26 on the Montreal Cognitive Assessment)
* Known history of cognitive impairment, dementia, stroke, seizure disorder, or other neuropsychiatric condition judged to impact cognitive performance.
* Taking medications known to influence cognitive performance.
* Sensory (e.g. visual, auditory) or physical (e.g. severe arthritic, orthopedic, neurologic) impairment incompatible with use of a standard computer workstation.
* Enrolled in a concurrent study that could affect the outcome of this study.

Primary outcomes:
measure: Changes in the Breakfast Game performance: Number of Tables Set Score
timeFrame: Training session 2, week 2; training 13, approximately 6 weeks.
measure: Changes in the Breakfast Game performance: Cooking time Range of Stop Times scores.
timeFrame: Training session 2, week 2; training 13, approximately 6 weeks.
measure: Change in Breakfast Game performance: Cooking Time Discrepancy scores
timeFrame: Training session 2, week 2; training 13, approximately 6 weeks.
measure: Transfer to complex executive/attention control measure (Proximal outcome).
timeFrame: Within the 2 weeks before intervention starts; and 6th week, after the last (13th) training session.
Secondary outcomes:
measure: Transfer to executive functions composite measure (Distal outcome)
timeFrame: Within the 2 weeks before intervention starts; and 6th week, after the last (13th) training session.
measure: Transfer to divided attention / speed measure (Distal outcome)
timeFrame: Within the 2 weeks before intervention starts; and 6th week, after the last (13th) training session.
measure: Transfer to episodic memory/learning measure (Distal outcome)
timeFrame: Within the 2 weeks before intervention starts; and 6th week, after the last (13th) training session.
measure: Transfer to the General Self-efficacy Scale (Distal outcome)
timeFrame: Within the 2 weeks before intervention starts; and 6th week, after the last (13th) training session.
measure: Transfer to Beck Depression Inventory (Distal outcome)
timeFrame: Within the 2 weeks before intervention starts; and 6th week, after the last (13th) training session.
measure: Transfer to Beck Anxiety Inventory (Distal outcome)
timeFrame: Within the 2 weeks before intervention starts; and 6th week, after the last (13th) training session.
measure: Transfer to Cognitive Failure Questionnaire (Distal outcome)
timeFrame: Within the 2 weeks before intervention starts; and 6th week, after the last (13th) training session.
measure: Transfer to Cognition-Leisure Questionnaire (Distal outcome)
timeFrame: Within the 2 weeks before intervention starts; and 6th week, after the last (13th) training session.
Other outcomes:
Locations:
city: New York
country: United States
facility: Columbia University Irving Medical Center
state: New York
Study officials:
affiliation: Columbia University
name: Sharon Sanz Simon, PhD
role: PRINCIPAL_INVESTIGATOR
References: