Clinical trial NCT02679547: The Effect of Breastfeeding on the Development of Appendicitis in Adults
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Appendicitis
Keywords: Appendix
Breastfeeding
Adult
Lead sponsor: Sisli Hamidiye Etfal Training and Research Hospital
Sponsor class: OTHER
Collaborators: name: Istanbul Training and Research Hospital
name: Bezmialem Vakif University
name: Arnavutkoy State Hospital
name: Bursa Yüksek İhtisas Education and Research Hospital
First posted: 2016-02-10
Enrollment: 1500
Sex: ALL
Minimum age (years): 20
Maximum age (years): 40
Standard ages: ADULT
Accepts healthy volunteers: yes
Observational model: CASE_CONTROL
Time perspective: CROSS_SECTIONAL
Sampling method: PROBABILITY_SAMPLE
Study population: 500 patients who has pathologically proven appendicitis, and 1000 participants without appendicitis.

Brief summary: Appendectomy is the most common emergent operative procedure performed worldwide. In this study investigators will investigate if there is a relationship between breast feeding and appendicitis in adults.

Detailed description: Acute appendicitis accounts for the commonest indication for emergency visits during daily surgical practice. Breast feeding is very important both mother and the child. For the infant, breast feeding has an important role on the maturity of immune system. In the literature search, there are a little studies about the relationship between the breast feeding and appendicitis. In the literature, some studies suggests that the breast feeding may possibly give protection against the development of appendicitis. But the number of the patients and the control groups are limited. Because of that the investigators have planned to make this study with a lot of number of patients.

Eligibility criteria: Inclusion Criteria:

* Subjects has pathologically proven appendicitis for appendicitis group.

Exclusion Criteria:

* Subjects has American Society of Anesthesiologists Physical Status classification 4,
* Subject has pregnancy,
* Subject has malignity,
* Subject has chronic illness,
* Subjects who won't accept to join the study
* Subjects who don't have family members

Primary outcomes:
measure: The breastfeeding status questionnaire in the appendicitis patients and participants without appendicitis
timeFrame: 2 days
Secondary outcomes:
Other outcomes:
Locations:
city: Bursa
country: Turkey
facility: Bursa Yuksek Ihtisas Training and Research Hospital
city: Istanbul
country: Turkey
facility: Sisli Etfal Training and Research Hospital
city: Istanbul
country: Turkey
facility: Arnavutkoy State Hospital
city: Istanbul
country: Turkey
facility: Bezmialem Vakif University
city: Istanbul
country: Turkey
facility: Istanbul Training and Research Hospital
Study officials:
References:
citation: Minniti F, Comberiati P, Munblit D, Piacentini GL, Antoniazzi E, Zanoni L, Boner AL, Peroni DG. Breast-milk characteristics protecting against allergy. Endocr Metab Immune Disord Drug Targets. 2014 Mar;14(1):9-15. doi: 10.2174/1871530314666140121145045.
citation: Pisacane A, de Luca U, Impagliazzo N, Russo M, De Caprio C, Caracciolo G. Breast feeding and acute appendicitis. BMJ. 1995 Apr 1;310(6983):836-7. doi: 10.1136/bmj.310.6983.836. No abstract available.
citation: Alves JG, Figueiroa JN, Barros I. Does breast feeding provide protection against acute appendicitis? A case-control study. Trop Doct. 2008 Oct;38(4):235-6. doi: 10.1258/td.2008.070404.