louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT06071377: Achieving Understanding of the Natural History of Sickle Cell Trait (AUNT)
Official title: Achieving Understanding of the Natural History of Sickle Cell Trait (AUNT)
Study type: OBSERVATIONAL
Overall status: RECRUITING
Conditions: Sickle Cell Trait
Lead sponsor: National Alliance for Sickle Cell Centers
Sponsor class: OTHER
Collaborators: name: Beam Therapeutics Inc.
First posted: 2023-10-06
Enrollment: 1000
Sex: ALL
Minimum age (years): 18
Maximum age (years): 65
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Adults aged 18-65 with sickle cell trait.

Brief summary: The main purpose of this study is to create a longitudinal cohort of those with Sickle Cell Trait (SCT) to better understand the hematologic phenotype for those that carry HbS, assess for differences in those with varying quantities of HbS and assess for potential clinical complications of SCT.


Eligibility criteria: Inclusion Criteria:

1. Are willing to voluntarily participate and sign the study consent
2. Know/suspect they have SCT and are willing to get tested to confirm/learn about their SCT status
3. Be willing and able to participate in the 2- year study plan.
4. Adults ages 18-65

Exclusion Criteria:

1. Unwilling to sign consent
2. Known end-stage renal disease or dialysis
3. Known SCD (including sickle cell-beta thalassemia)
4. People who do not have SCT

Primary outcomes:
measure: Hemoglobin variant quantification
timeFrame: Through study completion, an average of 2 years
Secondary outcomes:
measure: Red blood cell rheology
timeFrame: Through study completion, an average of 2 years
measure: Natural History
timeFrame: Through study completion, an average of 2 years
Other outcomes:
Locations:
city: Birmingham
country: United States
facility: University of Alabama
state: Alabama
city: Loma Linda
country: United States
facility: Loma Linda University Health Care
state: California
city: Wilmington
country: United States
facility: Nemours Children's Hospital
state: Delaware
city: Indianapolis
country: United States
facility: Indiana University
state: Indiana
city: Baltimore
country: United States
facility: Johns Hopkins University
state: Maryland
city: Chapel Hill
country: United States
facility: University of North Carolina
state: North Carolina
city: Durham
country: United States
facility: Duke University
state: North Carolina
city: Greenville
country: United States
facility: East Carolina University
state: North Carolina
city: Columbus
country: United States
facility: Nationwide Children's Hospital
state: Ohio
Study officials:
affiliation: National Alliance for Sickle Cell Centers
name: Julie Kanter, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT05979077: Children's Hospital Academic Medical Organization (CHAMO) MyChart Study
Official title: Improving Quality of Care in Diabetes Clinic Through Patient-Entered Electronic Health Data?
Study type: INTERVENTIONAL
Overall status: ACTIVE_NOT_RECRUITING
Phase: NA
Conditions: Diabetes Mellitus, Type 1
Lead sponsor: Children's Hospital of Eastern Ontario
Sponsor class: OTHER
First posted: 2023-08-07
Enrollment: 200
Sex: ALL
Minimum age (years): 0
Maximum age (years): 131
Standard ages: CHILD
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: HEALTH_SERVICES_RESEARCH

Brief summary: Evolving technology and clinical innovation have led to dramatic changes in the management of type 1 diabetes (T1D). These changes have led to a need to collect a growing number of details from families during their visits. As a result, much of the physician-patient visit is spent transferring information instead of focusing on diabetes care, contributing to increased time pressures in clinic and unmet needs for patients.

In response to this reality, the investigators have developed a tool that allows families to input their diabetes-related information into their physicians' electronic health record (EHR) documentation tool before their clinic visit, using a questionnaire administered via CHEO's secure patient portal (MyChart®). The investigators will evaluate the impact of an integrated electronic patient questionnaire, on quality of care (patient-reported), diabetes control and clinic efficiency. The investigators hope that our study will determine whether having families input clinical data prior to a visit is an effective strategy to improve the quality of diabetes care. The investigators believe that the findings will be of interest to all those studying the value of incorporating patient-entered data both within diabetes care and beyond.


Eligibility criteria: Inclusion Criteria:

* Diagnosis of T1D
* Age \<11 years at enrollment

Exclusion Criteria:

* Patients ≥ 11 years of age at enrollment
* Patients who are not fluent enough in English to complete all study related procedures
* Patients unable or unwilling to provide consent and/or assent
* Patients followed in Eating Disorder Clinic or Child and Youth Protection Clinic (there are MyChart activation restrictions for individuals followed in these clinics)

Primary outcomes:
measure: To evaluate the impact of a patient-facing EHR-enabled questionnaire on patient-perceived quality of care.
timeFrame: 12 months
measure: Patients' Evaluation of Quality of Diabetes Care (PEQD)
timeFrame: 12 months
measure: Perceived Quality of Medical Care (PQMC)
timeFrame: 12 months
measure: Participant Tool and Workflow Survey
timeFrame: 12 months
Secondary outcomes:
measure: To evaluate the impact of a patient-facing EHR-enabled questionnaire on glycemic control and visit efficiency.
timeFrame: 12 months
Other outcomes:
Locations:
city: Ottawa
country: Canada
facility: Children's Hospital of Eastern Ontario - Research Institute
state: Ontario
Study officials:
References:
Clinical trial NCT03404453: Difficult Airway Prediction in Paediatric Anaesthesia
Official title: Difficult Airway Prediction in Paediatric Anaesthesia:Prospective Observational Trial
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Difficult Airway
Keywords: Airway prediction
Difficult airway
Lead sponsor: Brno University Hospital
Sponsor class: OTHER
First posted: 2018-01-19
Enrollment: 399
Sex: ALL
Minimum age (years): 28
Maximum age (years): 19
Standard ages: CHILD
ADULT
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Paediatric patients at the preanaesthetic examination, scheduled for surgery under general anaesthesia

Brief summary: The incidence of difficult airway in paediatric population is up-to date not well described. Difficult airway is connected with significant airway-related morbidity and mortality. The majority of difficult airway in paediatric patients should be predictable. The aim of the study is to evaluate the incidence of difficult airway in paediatric patients scheduled for surgery under general anaesthesia and to test the predictability of the set of prediction tests to reveal the patients with high risk of difficult airway.

Detailed description: At the preanaesthetic visit the paediatric patients will be examined for difficult airway. The Mallampati score, interincisor garp, cervical spine mobility, upper lip bite test and thyromental distance will be measured. The distances will be measured in centimeters and the width of the distal part of the third finger will be measured to obtain the distance according to the patients fingers. The airway management plan will be defined and the incidence of the difficult airway (difficult face mask ventilation - two hand, two operators, desaturation, difficult intubation - Cormack-Leehane 3-4, intubation on 3 and more attempts, difficult laryngeal mask insertion and the incidence of cannot intubate cannot ventilate scenario will be evaluated. The predictability of the test for difficult airway prediction (Cormack-Leehane 3-4, cannot-intubate - cannot ventilate scenario, difficult mask ventilation) will be statistically analyzed.

Eligibility criteria: Inclusion Criteria:

- All paediatric patients scheduled for surgery under general anaesthesia On the preanaesthetic examination

Exclusion Criteria:

- Airway already secured by tracheostomy Surgery without securing the airway

Primary outcomes:
measure: Incidence of difficult airway in paediatric patients under general anaesthesia
timeFrame: during anaesthesia induction
Secondary outcomes:
measure: Predictability of difficult airway
timeFrame: during anaesthesia induction
Other outcomes:
Locations:
city: Brno
country: Czechia
facility: Brno University Hospital
Study officials:
References:
Clinical trial NCT05968053: Detection of Microplastics and Nanoplastics in Neurosurgery Patients (DT-MiNi)
Official title: Presence of Microplastics and Nanoplastics in Neurosurgery Patients
Study type: OBSERVATIONAL
Overall status: RECRUITING
Conditions: Carotid Artery Stenosis
Glioma
Intracranial Aneurysm
Intracranial Hemorrhages
Brain Tumor
Keywords: microplastics
nanoplastics
Intracranial Aneurysm
brain tumor
Carotid Artery Stenosis
Lead sponsor: Beijing Tiantan Hospital
Sponsor class: OTHER
First posted: 2023-08-01
Enrollment: 500
Sex: ALL
Minimum age (years): 18
Maximum age (years): 80
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Included patients age 18-80 years with any types of neurosurgery Excluded patients refuse to participate

Brief summary: Plastic particles are a ubiquitous pollutant in the living environment and food chain, so far, plenty of studies have reported the internal exposure of microplastics and nanoplastics in human tissues and enclosed body fluids.

Neurosurgery is the only department that can open the skull. In addition to blood and cerebrospinal fluid, there are brain tissue and tumors in the presence of lesions. Whether any of these microplastics and nanoplastics are present remains a mystery. This prospective observational study will harvest biological samples of neurosurgery patients.

The objective of this research is to be able to detect microplastics and nanoplastics on blood and operation samples of neurosurgery patients.


Eligibility criteria: Inclusion Criteria:

* Age 18-80 years
* Any type of neurosurgery

Exclusion Criteria:

·refusal of the patient to participate

Primary outcomes:
measure: microplastics
timeFrame: baseline, intraoperative
measure: nanoplastics
timeFrame: baseline, intraoperative
Secondary outcomes:
Other outcomes:
Locations:
city: Beijing
country: China
facility: Beijing Tiantan Hospital, Capital Medical University
state: Beijing
Study officials:
affiliation: Beijing Tiantan Hospital
name: Runting Li, MD
role: PRINCIPAL_INVESTIGATOR
affiliation: Beijing Tiantan Hospital
name: Yitong Jia, MD
role: PRINCIPAL_INVESTIGATOR
affiliation: Beijing Tiantan Hospital
name: Ke Wang, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT02326753: Gender and Proper Size of Oropharyngeal Airway: Pilot Study
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Adult Patients Undergoing Surgery That Requires General Anesthesia
Lead sponsor: Yonsei University
Sponsor class: OTHER
First posted: 2014-12-29
Enrollment: 36
Sex: ALL
Minimum age (years): 20
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NON_RANDOMIZED
Intervention model: CROSSOVER
Primary purpose: TREATMENT

Brief summary: The purpose of this study is to assess the adequacy of mask ventilation with the different sized-oropharyngeal airway.


Eligibility criteria: Inclusion Criteria:

* adult patients undergoing surgery that requires general anesthesia

Exclusion Criteria:

* anticipated difficult intubation
* patients without teeth or with loose teeth
* cervical spine disease
* body mass index over 35 kg/m2
* pregnancy

Primary outcomes:
measure: the proportion of patients whose oropharyngeal airway is proper
timeFrame: up to 10 minutes after the start of anesthetic induction
Secondary outcomes:
Other outcomes:
Locations:
city: Seoul
country: Korea, Republic of
facility: Department of Anesthesiology and Pain MedicineSeverance Hospital, Yonsei University Health System
state: Korea
Study officials:
References:
Clinical trial NCT04714853: Different Dialysis Modalities and Diet on Gastrointestinal Biome and Azotaemic Toxins
Official title: Pilot Study to Determine the Effect of Different Dialysis Treatment Modalities and Diet on Gastrointestinal Bacteria and Azotaemic Toxins
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Kidney Failure
Keywords: microbiome
haemodialysis
peritoneal dialysis
Lead sponsor: University College, London
Sponsor class: OTHER
Collaborators: name: University of Brighton
First posted: 2021-01-19
Enrollment: 100
Sex: ALL
Minimum age (years): 18
Maximum age (years): 80
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: CASE_ONLY
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: 100 dialysis patients

Brief summary: . This is a prospective observational pilot study to analyse gastrointestinal tract bacterial populations in peritoneal dialysis and haemodialysis patients under the care of the Royal Free Hospital with chronic kidney disease who have been established on regular haemodialysis and peritoneal dialysis treatments in a Royal Free Hospital kidney care centre.

Detailed description: Patients, attending for outpatient haemodialysis and peritoneal dialysis to be tested for gastrointestinal tract bacterial population by taking a single mouth swab, and a stool sample. Additional blood sampling, when patients are having blood tests for routine clinical assessment.

Eligibility criteria: Inclusion Criteria:

* Patients age 18 years and older up to 80 years
* Under the care of the Royal Free Hospital with chronic kidney disease and established on regular haemodialysis or peritoneal dialysis.
* Able to provide written informed consent obtained

Exclusion Criteria:

* Patients unable to provide written informed consent
* Patients not fulfilling inclusion criteria

Primary outcomes:
measure: generation of bacterial phylogenetic trees by identifying different bacteria from stool samples and oral swabs by analysis of bacterial ribosomal 16S
timeFrame: 5 years
Secondary outcomes:
measure: measure indoxyl sulphate (IS) and p-Cresyl sulfate (PCS) umol/L
timeFrame: 8 years
Other outcomes:
Locations:
city: London
country: United Kingdom
facility: Royal Free Hospital
Study officials:
affiliation: UCL Centre for Nephrology, Royal Free Hospital
name: andrew davenport
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT06346353: Substance Consumption, Personality, and Cognitive Functioning of Chess Players
Official title: Substance Consumption, Personality, and Cognitive Functioning of Chess Players and Non-chess Players - an Online Survey
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Addiction
Alcohol
Nicotine
Drugs
Personality
Depression
Anxiety
Lead sponsor: Central Institute of Mental Health, Mannheim
Sponsor class: OTHER
First posted: 2024-04-04
Enrollment: 756
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: CASE_CONTROL
Time perspective: CROSS_SECTIONAL
Sampling method: NON_PROBABILITY_SAMPLE
Study population: The survey is aimed at people who are at least 18 years old. There is no upper age limit. There is a division into two groups. Firstly, people who play chess in a club and have a DWZ (German rating). Secondly, there is a comparison group of people who do not play chess or only play chess as a hobby and therefore do not have a DWZ.

Brief summary: The aim of this project is to find out if there is a difference in addictive behavior, personality traits, and cognitive abilities between chess players and non-chess players.

Detailed description: In the present planned study, tournament chess players will be compared with non-tournament chess playing individuals by means of an online survey. Among other things, the investigators want to investigate whether these groups of persons differ in various characteristics such as their consumption behavior (alcohol, tobacco, and drug use), their personality, their depressiveness and mood, or their cognitive abilities. The background is the question whether playing chess could be protective against substance use disorders or could mitigate the manifestation.

Eligibility criteria: Inclusion Criteria:

* all persons from the age of 18 years
* Inclusion in the group of chess players is based on the existence of a DWZ.
* Sufficient ability to answer the questionnaires

Exclusion Criteria:

* None

Primary outcomes:
measure: Substance Craving
timeFrame: baseline
measure: Alcohol Use
timeFrame: baseline
measure: Automatic Alcohol Craving
timeFrame: baseline
measure: Severity of Nicotine Dependence
timeFrame: baseline
measure: Automatic Cigarette Craving
timeFrame: baseline
measure: Smoking Consequences
timeFrame: baseline
measure: Drug Abuse
timeFrame: baseline
measure: Personality
timeFrame: baseline
measure: Depression
timeFrame: baseline
measure: Anxiety
timeFrame: baseline
measure: self-efficacy
timeFrame: baseline
measure: coping with stress
timeFrame: baseline
measure: Inhibition capacity
timeFrame: baseline
measure: Working Memory capacity
timeFrame: baseline
Secondary outcomes:
Other outcomes:
Locations:
city: Mannheim
country: Germany
facility: Klinik für Abhängiges Verhalten, Zentralinstitut für Seelische Gesundheit
Study officials:
affiliation: Central Institute of Mental Health, Mannheim
name: Sabine Vollstädt-Klein, Prof. Dr.
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT02879253: Evaluation of Inter-patient Variability Size of the Nasal Cavity, Based on CT Scans
Official title: Evaluation of Inter-patient Variability Size of the Nasal Cavity, Based on CT Scans
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Nasal Cavity
Lead sponsor: Centre Hospitalier Universitaire de Besancon
Sponsor class: OTHER
First posted: 2016-08-25
Enrollment: 36
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: CASE_ONLY
Time perspective: RETROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: CT scans of men and women \> 18 years will be observed. Age selected corresponds to a period where the nasal cavity is completely formed, with no more structural and morphological changes due to the growth of the individual in the development phase; regarding sex study subjects, an equal distribution between men and women is required wherever possible.

Will be excluded images suggesting a pathology that could interfere with the target parameters of the study in the area, according to the opinion of the maxillofacial surgeon in charge of the collection (sinusitis, cancer, previous surgery ...).

Brief summary: This study is part of the french research program ANR NEMRO "MICROROBOTIC NASAL ENDOSCOPY BY OPTICAL COHERENCE TOMOGRAPHY: IMPACT OF SMELL DEFICIENCY ON NEURODEGENERATIVE DISEASES." Recent studies have shown a strong correlation between the decrease in olfactory faculties of patients and the presence of neurodegenerative diseases.

This possible relationship has created a need to inspect in detail the area of the nasal cavity that houses the olfactory function.

Thus, the purpose of NEMRO project is developing a robot to explore olfactory slots of patients, with a view to extract images through non invasive imaging probe, and hoping to identify early signs of degeneration the olfactory tissue. The robot developed will thus be able to navigate in the nasal cavity of patients, and to break into the olfactory slots, which will host the imaging phase.

The purpose of this study is therefore to collect data on the usual path of instruments (endoscope, for example) in this area, and future potential pathway of the robot. This collection made from Computed Tomography (CT) scans will define the clinical geometry of the target area and provide precisely the dimensional constraints needed to build the NEMRO robot .


Eligibility criteria: Inclusion Criteria:

* men or women aged \>18

Exclusion Criteria:

* any pathology observed on the scan (sinusitis, cancer, previous surgery ...), that could interfere with the evaluated parameters, according to the medical expert

Primary outcomes:
measure: Width of the nasal cavity and olfactory slots
timeFrame: at enrollment
measure: Geometry of the nasal cavity and olfactory slots
timeFrame: at enrollment
Secondary outcomes:
Other outcomes:
Locations:
city: Besançon
country: France
facility: CHU Besançon
Study officials:
References:
Clinical trial NCT02849353: Combination of Cryosurgey and NK Immunotherapy for Recurrent Ovarian Cancer
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE1
PHASE2
Conditions: Recurrent Ovarian Cancer
Keywords: Ovarian Cancer
cryosurgery
NK immunotherapy
Lead sponsor: Fuda Cancer Hospital, Guangzhou
Sponsor class: OTHER
Collaborators: name: Shenzhen Hank Bioengineering Institute
First posted: 2016-07-29
Enrollment: 30
Sex: FEMALE
Minimum age (years): 30
Maximum age (years): 70
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The aim of this study is the safety and efficacy of cryosurgery plus NK immunotherapy to recurrent ovarian cancer.

Detailed description: By enrolling patients with recurrent ovarian cancer adapted to enrolled criteria, this study will document for the first time the safety and the short and long term efficacy of the combined therapy using cryosurgery and natural killer (NK) cells.

The safety will be evaluated by statistics of adverse reactions. The efficacy will be evaluated according to local relief degree, progress free survival (PFS) and overall survival (OS).

Eligibility criteria: Inclusion Criteria:

* All standard therapies have failed according to NCCN guidelines or the patient refuses standard therapies after cancer recurrence
* Body tumor 1-6, the maximum tumor length \< 5 cm
* KPS ≥ 70, lifespan \> 6 months
* Platelet count ≥ 80×109/L，white blood cell count ≥ 3×109/L, neutrophil count ≥ 2×109/L, hemoglobin ≥ 80 g/L

Exclusion Criteria:

* Patients with cardiac pacemaker
* Patients with brain metastasis
* Patients with grade 3 hypertension or diabetic complication, severe cardiac and pulmonary dysfunction

Primary outcomes:
measure: Relief degree of tumors
timeFrame: 3 months
Secondary outcomes:
measure: Progress free survival（PFS）
timeFrame: 1 year
measure: Overall survival（OS）
timeFrame: 3 years
Other outcomes:
Locations:
city: Guangzhou
country: China
facility: Fuda cancer institute of Fuda cancer hospital
state: Guangdong
Study officials:
affiliation: Fuda Cancer Hospital, Guangzhou
name: Jibing Chen, MD, PhD
role: PRINCIPAL_INVESTIGATOR
References: