louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT06713759: Impact of Postural Balance Changes on Low Back Pain During Pregnancy
Official title: Impact of Postural Balance Changes on Low Back Pain During Pregnancy
Study type: OBSERVATIONAL
Overall status: NOT_YET_RECRUITING
Conditions: Pregnancy
Low Back Pain
Keywords: postural balance
low back pain
pregnacy
Lead sponsor: October 6 University
Sponsor class: OTHER
First posted: 2024-12-03
Enrollment: 40
Sex: FEMALE
Minimum age (years): 20
Maximum age (years): 35
Standard ages: ADULT
Accepts healthy volunteers: no
Observational model: OTHER
Time perspective: CROSS_SECTIONAL
Sampling method: NON_PROBABILITY_SAMPLE
Study population: This study will be conducted on forty pregnant women (in second and third trimesters) suffering from low back pain

Brief summary: this study will be conducted to determine the impact of postural balance changes on low back pain during pregnancy

Detailed description: Back pain is a major problem in the general population, and it is thought to be even more common in pregnant women who have given birth. It has been hypothesized that this type of pregnancy-related low back pain (LBP) may be related to changes in lumbar posture, perhaps accompanied by stretching abdominal muscles or specific hormonal effects of pregnancy .During pregnancy, many hormonal, anatomical, and musculoskeletal changes occur. These changes alter the postural balance and increase the risk of falls. Falls during pregnancy can cause maternal and foetal injuries. Moreover, the incidence of falls during pregnancy is higher compared to non-pregnant women of the same age. The risk of falls increases with the gestational age, and most falls are experienced in the third trimester. so, this study will be designed to conduct new information about the relation between postural changes and low back pain during pregnancy

Eligibility criteria: Inclusion Criteria:

* Pregnant women in 2nd and 3rd trimesters.
* Pregnant women suffering from low back pain
* Their Age will range from 20-35 years.
* Their Body mass index (BMI) will be less than 35 kg/m2

Exclusion Criteria:

* Non pregnant women.
* Women who have any history of diseases associated with balance disorder
* Women who have any Neurological disorders.
* Women who have Lower limbs deformities
* Women who have Optical problems and disorders
* Women who have Cerebrovascular disease

Primary outcomes:
measure: balance
timeFrame: up to thirty four weeks
measure: pressure pain threshold
timeFrame: up to thirty four weeks
Secondary outcomes:
measure: pain intensity
timeFrame: up to thirty four weeks
Other outcomes:
Locations:
Study officials:
References:
Clinical trial NCT03589859: Computerized Vestibular Rehabilitation
Official title: Computerized Game-based Vestibular Rehabilitation: Assessment of Feasibility and Motor Learning
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Vestibular Diseases
Keywords: neurologic rehabilitation
computer games
Lead sponsor: VA Office of Research and Development
Sponsor class: FED
First posted: 2018-07-18
Enrollment: 24
Sex: ALL
Minimum age (years): 18
Maximum age (years): 75
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: COHORT
Time perspective: CROSS_SECTIONAL
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Normal volunteers and patients with vestibular hypofunction

Brief summary: Disorders of vestibular function and balance are an important component of many conditions that commonly affect veterans, such as inner ear diseases, diabetes, and traumatic brain injury. Veterans with vestibular impairment have reduced quality of life, limitations on work and physical activities, and an increased risk of falls. The goal of this research is to develop a more engaging and effective interactive tool for vestibular rehabilitation to improve the lives of affected veterans. The first steps in this process will be to test the ability of the application to facilitate vestibular learning and to test its feasibility in vestibular patients. The hypothesis is that computer-game-based adaptation will induce robust VOR motor learning and will provide an engaging platform for vestibular rehabilitation. Ultimately, our application has the potential to provide more flexible vestibular exercises that will allow therapy to be customized for each patient. It will also have the ability to track a patient's progress over time and to advance exercises as function improves.


Eligibility criteria: Inclusion Criteria:

* GROUP 1: Healthy volunteers: Static visual acuity of at least 20/30 at testing distance
* GROUP 2: Vestibular patients: Unilateral or bilateral vestibular hypofunction, No central vestibular disorder, Static Visual Acuity of at least 20/30 at testing distance

Exclusion Criteria:

* GROUP 1: Peripheral or central vestibular disorder
* GROUP 2: Central vestibular disorder

Primary outcomes:
measure: Vestibulo-ocular Reflex Gain Ratio
timeFrame: VOR measurements to determine gain were performed immediately before and after each approximately 30 minute training session. Pre- and post-training gains were then combined in the VOR gain ratio to determine the training effect.
Secondary outcomes:
Other outcomes:
measure: Nausea Scale
timeFrame: Immediately after each 10-minute game block, median value calculated for each participant
Locations:
city: Cleveland
country: United States
facility: Louis Stokes VA Medical Center, Cleveland, OH
state: Ohio
Study officials:
affiliation: Louis Stokes VA Medical Center, Cleveland, OH
name: Mark F. Walker, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT00224159: Does Statin Initiation Undermine Dietary Behavior?
Official title: Does Statin Initiation Undermine Dietary Behavior?
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: All English Speaking Adults From the Manhattan VA Clinic Who Have Recently Received Their First Prescription for a Statin
Keywords: Statin therapy
Dietary behavior
Attitudes and beliefs
Self efficacy
Lead sponsor: Weill Medical College of Cornell University
Sponsor class: OTHER
Collaborators: name: Agency for Healthcare Research and Quality (AHRQ)
First posted: 2005-09-22
Enrollment: 100
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Sampling method: PROBABILITY_SAMPLE
Study population: All English-speaking adults who have recently (within 1 week)received their first prescription for a statin will be eligible.

Brief summary: The purpose of this research is to improve our understanding of the effects that taking cholesterol reducing pills have on dietary behavior as well as other health related behaviors

Detailed description: This study explores the impact of initiating statin therapy on subsequent dietary as well as other lifestyle beliefs, attitudes and behaviors.

Specific aims:

1. To test whether the initiation of statin therapy increases dietary saturated fat intake among statin naive patients.
2. To determine what role attitudes, beliefs, expectations, motivation, intention and self-efficacy regarding drug or diet therapy may play in observed changes in dietary behavior after starting statin therapy.

Eligibility criteria: Inclusion Criteria:

All English-speaking adults who have recently (within 1 week)received their first prescription for a statin will be eligible.

Exclusion Criteria:

Will include a history of any of the following:

1. Prior CVD (myocardial infarction, angina, angioplasty, stroke, CABG. or arterial bypass surgery)
2. Diabetes patients
3. Psychiatric patients
4. AIDS patients
5. Substance abuse patients
6. Prior cholesterol lowering medication use
7. Inability to complete the interviews

Primary outcomes:
measure: How drug or dietary therapy may play a role in dietary behavior.
Secondary outcomes:
Other outcomes:
Locations:
city: New York
country: United States
facility: The New York Presbyterian Hospital-Weill Medical Center
state: New York
Study officials:
affiliation: Weill Medical College of Cornell University
name: Sundar Natarajan, MD, MSc
role: PRINCIPAL_INVESTIGATOR
affiliation: Weill Medical College of Cornell University
name: Devin Mann, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT03237559: Assessment of Knowledge, Attitude and Practice of Eligible Couples Regarding Eugenics
Official title: A Descriptive Comparative Study to Assess Knowledge, Attitude and Practice Regarding Eugenics Among Eligible Couples of Selected Area of Ambala, Haryana (India)
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Knowledge, Attitudes, Practice
Keywords: Eugenics
Eligible Couples
Knowledge
Attitude
Practice
Lead sponsor: Maharishi Markendeswar University (Deemed to be University)
Sponsor class: OTHER
First posted: 2017-08-02
Enrollment: 318
Sex: ALL
Minimum age (years): 15
Maximum age (years): 45
Standard ages: CHILD
ADULT
Accepts healthy volunteers: yes
Observational model: FAMILY_BASED
Time perspective: OTHER
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Eligible couples of rural and urban areas of Ambala Haryana, India

Brief summary: A Descriptive study to assess the knowledge, attitude and practice regarding eugenics among eligible couples of selected area of Ambala, Haryana, India. Eligible couples were the married couples where wife is in the age group of 15-45 years planning for conception, have conceived and may or may not have any living child.Eugenics are to methods that are adopted by eligible couples for having physically and psychologically healthy conception and pregnancy.

Detailed description: To assess the knowledge, attitude and practice the structured knowledge questionnaire, attitude 5-point likert scale and expressed checklist tool were prepared. A sample size of 318 was calculated by power analysis and eligible couples were selected by Purposive sampling technique from rural and urban area of Ambala Haryana, India.

Each eligible couples (separately husband and wife) data was collected through Self- Report technique.one time assessment only done.

Eligibility criteria: Inclusion Criteria:

* who were present at the time of data collection
* who were willing to participate in the study
* who can read and write English/Hindi

Exclusion Criteria:

* who have more than 2 children
* who had undergone permanent sterilization

Primary outcomes:
measure: Structured Questionnaire
timeFrame: 15-20 min
Secondary outcomes:
measure: Structured Attitude 5-point likert Scale
timeFrame: 10-15 min
measure: Expressed Husband Checklist
timeFrame: 7-8min
measure: Expressed Wife Checklist
timeFrame: 10-12min
Other outcomes:
Locations:
Study officials:
affiliation: M.M.University, Mullana, Ambala Haryana, India
name: Dr. Poonam Sheoran, Ph.d Nursing
role: STUDY_DIRECTOR
References:
citation: Okka B, Durduran Y, Degerli Kodaz N. Traditional practices of Konya women during pregnancy, birth, the postpartumperiod, and newborn care. Turk J Med Sci. 2016 Feb 17;46(2):501-11. doi: 10.3906/sag-1504-120.
citation: Charafeddine L, El Rafei R, Azizi S, Sinno D, Alamiddine K, Howson CP, Walani SR, Ammar W, Nassar A, Yunis K. Improving awareness of preconception health among adolescents: experience of a school-based intervention in Lebanon. BMC Public Health. 2014 Jul 31;14:774. doi: 10.1186/1471-2458-14-774.
Clinical trial NCT01210859: Effects of Antimuscarinic Drugs on Overactive Bladder (OAB) Symptoms After Insertion of Ureteral Stents
Official title: Effects of Antimuscarinic Drugs on OAB Symptoms After Insertion of Ureteral Stents
Study type: OBSERVATIONAL
Overall status: WITHDRAWN
Conditions: Overactive Bladder
Keywords: detrusitol
overactive
bladder
ureteral
stents
Lead sponsor: Meir Medical Center
Sponsor class: OTHER
First posted: 2010-09-29
Enrollment: 0
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: CASE_CONTROL
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: patients which underwent ureteral stent insertion

Brief summary: The purpose of this study is to check whether antimuscarinics that usually broadly used in the treatment of overactive bladder symptoms are effective in the treatment of those symptoms after insertion of ureteral stents. In order to study the efficacy of the treatment of OAB symptoms in stented patients the investigator will use a suitable questionnary.


Eligibility criteria: Inclusion Criteria:

* everyone who underwent ureteral stent insertion and started the treatment with detrusitol

Exclusion Criteria:

* adverse affects of detrusitol or unwillness of the patient to continue the treatment with detrusitol, cronic renal or hepatic failure

Primary outcomes:
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
References:
Clinical trial NCT05130359: Evaluation of the Sleep-relieving Effect of Banana Peel Extract
Official title: Explore Whether Banana Peel Extract Can Improve Sleep
Study type: INTERVENTIONAL
Overall status: ACTIVE_NOT_RECRUITING
Phase: NA
Conditions: Impaired Attention
Lead sponsor: TCI Co., Ltd.
Sponsor class: INDUSTRY
First posted: 2021-11-23
Enrollment: 56
Sex: ALL
Minimum age (years): 20
Maximum age (years): 65
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: Banana peel has the potential to improve sleep quality. The purpose of this research is to test the effect of banana peel on improving sleep quality.

Detailed description: Insomnia is one of the most frequently complained sleep problems in sleep disorders, and in recent years has been regarded by the medical community as a disease that seriously affects people's lives and quality of life. The problem of perishable and perishable causes a great burden on the environment. However, banana peels actually contain many functional ingredients, such as dietary fiber, minerals, alkaloids, flavonoids, phenols, saponins, tannins and dopamine, etc. Banana peel contains more total phenols and total flavonoids than banana pulp. Studies have pointed out that banana peel extraction can inhibit the growth of fungi and bacteria. In addition, it also has antioxidant, anti-depressant, and diuretic functions. Banana peel can also improve the performance of tryptophan metabolism-related genes

Eligibility criteria: Inclusion Criteria:

1.20 to 65-year-old males or non-pregnant females who are willing to sign the subject's consent.

2.Pittsburgh Sleep Quality Index (PSQI) score\> 5

Exclusion Criteria:

1. Taking sleeping pills and melatonin
2. People suffering from mental illness
3. Pregnant or breastfeeding women
4. People who are known to be allergic to bananas
5. Have heart-related diseases
6. People with symptoms of sleep cessation

Primary outcomes:
measure: Sleep monitoring
timeFrame: at 4 week after taking test sample
measure: Serotonin
timeFrame: at 4 week after taking test sample
measure: Melatonin
timeFrame: at 4 week after taking test sample
measure: Sleeping quality
timeFrame: at 4 week after taking test sample
measure: Insomnia Severity
timeFrame: at 4 week after taking test sample
Secondary outcomes:
Other outcomes:
measure: The change of liver function biomarkers (AST, ALT) of blood
timeFrame: at 4 week after taking test sample
measure: The change of renal function biomarkers (creatinine, BUN) of blood
timeFrame: at 4 week after taking test sample
measure: The change of fasting blood glucose
timeFrame: at 4 week after taking test sample
measure: The change of Blood lipids profiles (Total-Cholesterol, HDL-C, LDL-C, triglycerides)
timeFrame: at 4 week after taking test sample
Locations:
city: Taipei
country: Taiwan
facility: Taipei Medical University
Study officials:
affiliation: Taipei Medical University
name: Hsin-Chien Lee, Doctor
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT06747559: Effects of Vitamin D Supplementation on Postoperative Rehabilitation in Hip and Knee Osteoarthritis Patients
Official title: Effects of Vitamin D Supplementation on Postoperative Rehabilitation in Hip and Knee Osteoarthritis Patients: a Multicenter Randomized Controlled Trial
Study type: INTERVENTIONAL
Overall status: NOT_YET_RECRUITING
Phase: NA
Conditions: Osteoarthritis of the Hip or Knee
Joint Arthroplasty
Lead sponsor: Second Affiliated Hospital, School of Medicine, Zhejiang University
Sponsor class: OTHER
Collaborators: name: Yiwu Fuyuan Private Hospital
name: Hangzhou Xiaoshan Traditional Chinese Orthopedic Hospital
First posted: 2024-12-24
Enrollment: 300
Sex: ALL
Minimum age (years): 60
Maximum age (years): 85
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The goal of this clinical trial is to learn if vitamin D supplementation affects postoperative rehabilitation in osteoarthritis patients who underwent joint arthroplasty. The main questions it aims to answer are:

Does oral vitamin D supplementation for a period of time after joint arthroplasty affect the postoperative recovery speed in patients who have vitamin D deficiency? Does oral vitamin D supplementation after joint arthroplasty affect the long-term recovery of joint functions in patients who have vitamin D deficiency?

Participants will:

Take vitamin D oral supplement every day for 3 months. Visit the clinic in 1, 3, 6, 12 months after joint replacement surgery for checkups and tests.


Eligibility criteria: Inclusion Criteria:

1. Vitamin D deficiency (blood 25-hydroxyvitamin D value \< 20ng/ml);
2. Meeting the diagnostic criteria for hip or knee osteoarthritis;
3. Planning to undergo hip or knee arthroplasty after clinical assessment;

Exclusion Criteria:

1. Having other diseases that could cause damage to the bone or cartilage structure of the hip or knee, such as trauma, joint infection, congenital joint malformation, and systemic diseases such as rheumatoid arthritis and gout.

Primary outcomes:
measure: Knee joint function
timeFrame: From enrollment to the end of treatment at 1 year
measure: Hip joint function
timeFrame: From enrollment to the end of treatment at 1 year
measure: Muscle strength
timeFrame: From enrollment to the end of treatment at 1 year
Secondary outcomes:
Other outcomes:
Locations:
city: Hangzhou
country: China
facility: 2nd Affiliated Hospital, School of Medicine, Zhejiang University
state: Zhejiang
Study officials:
affiliation: 2nd Affiliated Hospital, School of Medicine, Zhejiang University
name: Xiang Zhao, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT04544059: Lenalidomide Plus R-CHOP for CNS Relapse Prophylaxis in Diffuse Large B-cell Lymphoma
Official title: Lenalidomide Plus R-CHOP for CNS Relapse Prophylaxis in Diffuse Large B-cell Lymphoma
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: PHASE2
Conditions: Diffuse Large B Cell Lymphoma
Keywords: diffuse large b cell lymphoma
central nervous system
Lenalidomide
Lead sponsor: Nanfang Hospital, Southern Medical University
Sponsor class: OTHER
First posted: 2020-09-10
Enrollment: 87
Sex: ALL
Minimum age (years): 18
Maximum age (years): 70
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: PREVENTION

Brief summary: This is an open-label, multicenter, phase 2 trial to explore the efficacy and safety of the combination of lenalidomide and R-CHOP for preventing the CNS relapse in the high-risk diffuse large B cell lymphoma.


Eligibility criteria: Inclusion Criteria:

age 18-72 years histologically confirmed DLBCL High risk for CNS recurrence: CNS-IPI:4-6 or involvement of testicular, kidneys or adrenal glands.

No pregnancy plans during treatment

Exclusion Criteria:

Evidence of CNS involvement, Transformed lymphoma, Primary mediastinal B-cell lymphoma EBV+DLBCL, Secondary malignancy, HIV positive, Creatinine \> 2.0 mg/dl Intending to hematopoietic stem cell transplantation history of severe thrombus Pregnant or lactating women

Primary outcomes:
measure: The 2-year central nervous system relapse rates
timeFrame: two year
Secondary outcomes:
measure: The 2-year overall survival
timeFrame: two year
measure: The 2-year progression-free survival
timeFrame: two year
measure: Incidence of treatment-emergent adverse events
timeFrame: two year
Other outcomes:
Locations:
city: Guangzhou
country: China
facility: Nanfang hospital
state: Guangdong
Study officials:
affiliation: Department of Hematology, Nanfang Hospital, Southern Medical University
name: Ru Feng
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT02284659: Effect of Functional Electrical Stimulation on Erectile Dysfunction
Official title: Effect of Functional Electrical Stimulation on Erectile Dysfunction
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Erectile Dysfunction
Lead sponsor: Federal University of Health Science of Porto Alegre
Sponsor class: OTHER
First posted: 2014-11-06
Enrollment: 22
Sex: MALE
Minimum age (years): 40
Maximum age (years): 70
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: Objective: The aim of this study is to evaluate the FES effect on erectile function in men with erectile dysfunction.

Expected Results: The hypothesis is that treatment with FES decrease erectile dysfunction.

Detailed description: Introduction: Erectile dysfunction (ED) affects approximately 150 million men worldwide. The application of functional electrical stimulation (FES) has been used due to the high regenerative capacity of smooth muscle cells. This approach can be beneficial in the treatment of which usually has the ultimate causes cavernous smooth muscle degeneration.

Objective: The aim of this study is to evaluate the FES effect on erectile function in men with erectile dysfunction.

Methods: Randomized Clinical Trial will be selected in which 30 patients with erectile dysfunction. The men included will be randomized into two groups. The intervention group will conduct therapy with FES (50Hz / 500us) for 15 minutes with intensity below the motor threshold and the control group will use FES placebo. Two sessions will be held weekly for four weeks. Erectile function will be assessed using the validated questionnaire IIEF-5. The instrument will be completed by blinded researcher and the technique is randomized and the treatment done randomly.

Expected Results: The hypothesis is that treatment with FES decrease erectile dysfunction.

Eligibility criteria: Inclusion Criteria:

* Male patient
* 40 to 65 years of age, with stable marital relationship (6 months)
* Diagnosis of erectile dysfunction (score of less than 22 IIEF5)
* Clinical history of ED for at least 6 months

Exclusion Criteria:

* A neurogenic (spinal cord injury, Parkinson's, MS, post prostatectomy)
* Hypogonadism (total testosterone \<300 ng / dl)
* Patient reporting use of inhibitors or 5PDE FIC in the last 60 days
* Diagnosis of coronary artery disease and / or cerebrovascular disease
* Impossibility of understanding the goals, technical study and informed consent cognitive impairment

Primary outcomes:
measure: Erectile function with International Index of Erectile Function-5 questionnaire
timeFrame: 2 times a week for 30 minutes
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
References: