louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT03630406: Vaginal Elasticity Assessment Before and After Vaginal Carbon Dioxide Laser Treatment.
Official title: Vaginal Elasticity Assessment Before and After Vaginal Carbon Dioxide Laser Treatment.as Measured by Vaginal Tactile Imaging.
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Laser Burn
Lead sponsor: Rambam Health Care Campus
Sponsor class: OTHER
First posted: 2018-08-14
Enrollment: 25
Sex: FEMALE
Minimum age (years): 18
Maximum age (years): 75
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Female patients with either SUI or vaginal wall weakness and prolapse.

Brief summary: Female patients with either stress urinary incontinence (SUI) or vaginal wall weakness and prolapse will be evaluated for vaginal elasticity using vaginal tactile imaging both before and after Carbon Dioxide laser treatment.

Detailed description: Patients will be recruited and sign a consent form. The patients included are patients with SUI or vaginal wall weakness and prolapse. Each participant undergoes 3 laser treatments 4 weeks apart.

Assessment of vaginal elasticity via vaginal tactile imaging will be performed at 3 different points:

* Before the first treatment session (baseline).
* Before and after each treatment session.
* 3 months post final treatment. Every patient will serve as her own control. Demographic, gynecologic and obstetric history will be obtained from patients' electronic files.

Eligibility criteria: Inclusion Criteria:

* Any woman undergoing vaginal Carbon Dioxide laser treatment.

Exclusion Criteria:

* Women that are not in the age range.

Primary outcomes:
measure: Vaginal elasticity assessment
timeFrame: up to 3 months from enrollment
Secondary outcomes:
Other outcomes:
Locations:
city: Haifa
country: Israel
facility: Rambam health care campus
Study officials:
affiliation: Principal Investigator
name: Roy Lauterbach, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT01914406: High-intensity Interval Training Versus Moderate Continuous Training in Heart Transplant Recipients.
Official title: High-intensity Interval Training Versus Moderate Continuous Training in Heart Transplant Recipients With Impaired Chronotropic Response: A Randomized Controlled Crossover Trial.
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Heart Transplant Recipients
Keywords: Heart transplant recipients
Exercise capacity
endothelial function
Quality of life
Lead sponsor: Bispebjerg Hospital
Sponsor class: OTHER
First posted: 2013-08-02
Enrollment: 20
Sex: ALL
Minimum age (years): 18
Maximum age (years): 80
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: CROSSOVER
Primary purpose: TREATMENT

Brief summary: The aim of this study was to examine the effects of high intensity aerobic interval training (AIT) versus moderate continuous training (CON) in heart transplant recipients.

Detailed description: Clinically stable heart transplant recipients \> 12 month or more after HTx, age \> 18 years, willing and capable of giving written informed consent for study participation and anticipated to be able to participate in the study for 12 months were included from the Heart Centre, Rigshospitalet, Copenhagen University Hospital.

Patients were excluded due to unstable condition or postoperative complications, recent severe rejection episodes (\>H1R \< 3 month), physical disabilities which prevent participation and re-transplantation or multi-organtransplantation.

Eligibility criteria: Inclusion Criteria:

-stable Heart transplant recipients \> 12 month or more after HTx, age \> 18 years,\< 80. willing and capable of giving written informed consent for study participation.

Exclusion Criteria:

unstable condition postoperative complications, recent severe rejection episodes (\>H1R \< 3 month), re-transplantation or multi-organtransplantation.

Primary outcomes:
measure: VO2peak
timeFrame: baseline test (inclusion), follow-up 1(3 month), follow-up 2 (8 month), follow-up 3 (11 month).
Secondary outcomes:
measure: Endothelial function (endoPAT)
timeFrame: baseline test (inclusion), follow-up 1(3 month), follow-up 2 (8 month), follow-up 3 (11 month).
measure: Quality of Life (QoL)SF-36
timeFrame: baseline test (inclusion), follow-up 1(3 month), follow-up 2 (8 month), follow-up 3 (11 month).
measure: HADS-a, HADS-d anxiety and depression
timeFrame: baseline test (inclusion), follow-up 1(3 month), follow-up 2 (8 month), follow-up 3 (11 month).
measure: Bloodsamples/biomarkers.
timeFrame: baseline test (inclusion), follow-up 1(3 month), follow-up 2 (8 month), follow-up 3 (11 month).
measure: augmentation index (AI), endoPAT
timeFrame: baseline test (inclusion), follow-up 1(3 month), follow-up 2 (8 month), follow-up 3 (11 month).
Other outcomes:
Locations:
city: Copenhagen
country: Denmark
facility: Cardiac Rehabilitation, Bispebjerg University Hospital
Study officials:
affiliation: Bispebjerg Hospital, Denmark
name: Christian H Dall, cand.scient
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT00823706: Prevalence of Angle Closure in Caucasian Hyperopes
Official title: Prevalence of Chronic Angle Closure in Caucasian Hyperopic Subjects
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Chronic Angle Closure Glaucoma
Keywords: chronic angle closure hyperopia
Lead sponsor: Assaf-Harofeh Medical Center
Sponsor class: OTHER_GOV
First posted: 2009-01-16
Enrollment: 100
Sex: ALL
Minimum age (years): 40
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Caucasian subjects aged 40 years or more with hyperopia

Brief summary: The primary purpose of this study is to assess the prevalence of asymptomatic chronic angle closure in high risk Caucasian individuals, namely those with hyperopia. A secondary purpose is to assess whether specific demographic or ocular-anatomic parameters in this population are associated with a higher risk for angle closure.

Detailed description: Caucasian subjects aged \> 40 years with hyperopia will undergo complete eye examination including subjective refraction and gonioscopy. In addition we will measure axial length, anterior chamber depth and lens thickness using ultrasound biometry.

Eligibility criteria: Inclusion Criteria:

* Age greater than 40 years
* Hyperopia greater then +1.00 D spherical equivalent

Exclusion Criteria:

* Any identifiable eye disease or previous eye surgery that can affect the anatomy of the irido-corneal angle

Primary outcomes:
measure: prevalence of chronic angle closure in Caucasian hyperopes
timeFrame: 1 year
Secondary outcomes:
measure: relative risk for chronic angle closure measured for demographic and ocular-anatomic parameters
timeFrame: 1 year
Other outcomes:
Locations:
city: Zerifin
country: Israel
facility: Assaf Harofe Medical Center Ophthalmology Department
Study officials:
References:
Clinical trial NCT01012206: Overweighed Children´s Health - Studies of the Effect of Lifestyle and Food Habits
Official title: Overweighed Children´s Health - Studies of the Effect of Lifestyle and Food Habits
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Overweight
Obesity
Keywords: Children
Overweight
Obesity
Food habits
Dietary assessment
Physical activity
Lead sponsor: Umeå University
Sponsor class: OTHER
First posted: 2009-11-11
Enrollment: 105
Sex: ALL
Minimum age (years): 8
Maximum age (years): 12
Standard ages: CHILD
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: PREVENTION

Brief summary: The aim is to investigate the development of overweight and obesity from infancy to school age, and to evaluate an intervention to prevent further development of overweight and obesity among children.

A follow-up study will be conducted on 267 children and will allow comparison between children that developed overweight with the ones who did not. Subjects will be requited at 10 years of age from a previous project. These children have been studied when they were 6-18 months old and a follow-up was conducted at 4 years of age. Sixteen percent of the children were overweight at 4 years of age and retrospective data of e.g. food intake, blood lipids and anthropometric measurements exists. In the present follow-up data regarding food and physical activity habits, anthropometric measurements and blood samples of e.g. blood lipids, IGF1 will be collected.

An intervention study will be conducted on 80-120 overweight children that will be randomized into one intervention and one control group. An intervention during two years will encourage long term healthy habits regarding diet and physical activity through group meetings and supervision. Information about food habits will be collected through questionnaires, interviews and diaries. Measurement of physical activity and energy expenditure will be made with Sense Wear and double labeled water, and will be used to validate reported food intake. Further, anthropometric measurements and blood samples will be collected.


Eligibility criteria: Inclusion Criteria for SELFH intervention study:

* age and gender adjusted body mass index (BMI) \> 25
* born in 1995-1998
* living in or nearby the northern city of Umea, Sweden

Exclusion Criteria for SELFH intervention study:

* no chronic disease that could influence metabolic parameters
* no attention deficit disorders
* no access to internet

Primary outcomes:
measure: Body Mass Index
timeFrame: Two years
Secondary outcomes:
measure: Food intake
timeFrame: Two years
measure: Physical activity
timeFrame: Two years
Other outcomes:
Locations:
city: Umeå
country: Sweden
facility: Umeå university
Study officials:
affiliation: Department of Food and Nutrition, Umeå university.
name: Christel Larsson, PhD
role: PRINCIPAL_INVESTIGATOR
References:
citation: Waling MU, Larsson CL. Energy intake of Swedish overweight and obese children is underestimated using a diet history interview. J Nutr. 2009 Mar;139(3):522-7. doi: 10.3945/jn.108.101311. Epub 2009 Jan 21.
Clinical trial NCT07002606: The General Objective of This Study is to Monitor, Assess, and Prevent the Potential Medication Errors Among Inpatients in the Tertiary Healthcare Facility of Nepal. This Study Aims to Develop and Implement the Medication Errors Reporting System in Hospital Settings.
Official title: Monitoring, Assessment, and Prevention of Potential Medication Errors in the Tertiary Healthcare Facility of Nepal: A Mixed-method Study
Study type: OBSERVATIONAL
Overall status: NOT_YET_RECRUITING
Conditions: Prescription With Medication Errors
Keywords: Medication errors
Mixed method study
tertiary healthcare facility
Lead sponsor: Kathmandu University School of Medical Sciences
Sponsor class: OTHER
First posted: 2025-06-03
Enrollment: 62
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: OTHER
Time perspective: CROSS_SECTIONAL
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Healthcare professionals including Doctors, Nurses and Pharmacist who are working in Dhulikhel Hospital.

Brief summary: The goal of this observational study is to develop and implement Medication errors reporting system using the error reporting guidelines. The main question it aims to answer is:

"Does development and implementation of Medication errors reporting guideline will help to reduce the errors rate and improve the patient safety?"


Eligibility criteria: Inclusion Criteria:

* For the quantitative part, the inclusion criteria are patients of all age groups and prescriptions issued to inpatients.
* For the qualitative part of the study, inclusion criteria are healthcare professionals aged more than 18 years working in Dhulikhel Hospital.

Exclusion criteria:

* The exclusion criteria will be incomplete and unclear prescriptions.
* The healthcare persons who accepted the consent but couldn't complete the survey will be excluded from the study.

Primary outcomes:
measure: reduction in Mediation error rate
timeFrame: 6 months after the implementation of the Medication errors reporting guidelines
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
affiliation: Kathmandu University School of Medical Science
name: Dr. Sony Shakya Professor in Pharmacology, PhD
role: STUDY_DIRECTOR
References:
Clinical trial NCT06123806: Factors Affecting Dialysis Associated Fatigue
Official title: Factors Affecting Dialysis Associated Fatigue
Study type: OBSERVATIONAL
Overall status: NOT_YET_RECRUITING
Conditions: Dialysis; Complications
Lead sponsor: Assiut University
Sponsor class: OTHER
First posted: 2023-11-09
Enrollment: 120
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: CROSS_SECTIONAL
Sampling method: NON_PROBABILITY_SAMPLE
Study population: A convenient sample of adult hemodialysis patients (age ≥ 18 years) who have been on hemodialysis for at least 3 months will be recruited.

Brief summary: The aim of this study is to investigate the factors affecting hemodialysis-associated fatigue and their impact on the physical and emotional well-being of patients. By identifying these factors, Investigators can develop effective strategies to reduce fatigue and enhance the overall quality of life for hemodialysis patients.

Detailed description: Chronic kidney disease (CKD) is a significant public health issue affecting millions of individuals worldwide. Hemodialysis, the most common modality for renal replacement therapy, is a life-sustaining procedure for end-stage renal disease (ESRD) patients. Despite its benefits, hemodialysis can be associated with various complications, and one of the most commonly reported symptoms is fatigue. Hemodialysis-associated fatigue (HAF) is characterized by persistent tiredness, lack of energy, and reduced motivation, which significantly impacts the quality of life and functional capacity of patients.

Several potential factors contribute to HAF, including patient-related variables, dialysis-related factors, and comorbidities. Understanding the underlying mechanisms and factors contributing to HAF is essential for improving the overall care and quality of life of hemodialysis patients. Targeted interventions to address fatigue could lead to better adherence to dialysis treatment, reduced hospitalizations, and enhanced overall well-being for this vulnerable patient population. To date, limited research has been conducted on the subject of HAF, and the available studies often have small sample sizes and diverse methodologies. Therefore, this research aims to delve into the complexities of HAF, exploring its prevalence, potential risk factors, and implications for patient outcomes.

Eligibility criteria: Inclusion Criteria:

* adult hemodialysis patients aged ≥ 18 years
* patients on hemodialysis for at least 3 months

Exclusion Criteria:

* patients aged \< 18 years
* patients with acute kidney injury
* patients with cognitive impairment or inability to provide informed consent

Primary outcomes:
measure: Factors affecting dialysis associated fatigue
timeFrame: baseline
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
References:
Clinical trial NCT00333606: Acupuncture and Auditory Evoked Potentials
Official title: Effects of Acupuncture on the Auditory Evoked Potentials: a Randomized Volunteer Crossover Study
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Evoked Potentials
Healthy Volunteers
Lead sponsor: University Medicine Greifswald
Sponsor class: OTHER
First posted: 2006-06-06
Enrollment: 60
Sex: ALL
Minimum age (years): 20
Maximum age (years): 40
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: CROSSOVER
Primary purpose: BASIC_SCIENCE

Brief summary: To investigate whether body acupuncture of acupuncture points specific for hearing influences the auditory avoked potentials in comparison to puncture of non-specific acupuncture points


Eligibility criteria: Inclusion Criteria:

1. Healthy volunteers aged 20-40 years
2. Physical status I according to American Society of Anesthesiologists (ASA) classification
3. No history of nervous or psychiatric disease
4. Normal audiogram before the study
5. No chronic consume of analgesics, anticoagulants and/or antiplatelet agents, sedatives or alcohol
6. No local infection at the site of acupuncture
7. Volunteers who have given informed consent

Exclusion Criteria:

1. Pregnant or nursing females.
2. History of peripheral neuropathy
3. Abnormal skin conditions (infection, scars, psoriasis, eczema)
4. Inflamed site of acupuncture within 1 week

Primary outcomes:
measure: Latencies of Auditory Evoked Potentials
timeFrame: before acupuncture stimulation
Secondary outcomes:
measure: Pain Intensity
timeFrame: 30 min
Other outcomes:
Locations:
city: Greifswald
country: Germany
facility: Ernst Moritz Arndt University
Study officials:
affiliation: Ernst Moritz Arndt University
name: Taras I Usichenko, M.D.
role: STUDY_CHAIR
affiliation: Ernst Moritz Arndt University
name: Reinhard Schmidt, M.D.
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT02815306: Polyaxial Brace Fixing for the Treatment of Congenital Clubfoot
Official title: Polyaxial Brace Fixing for the Treatment of Congenital Clubfoot in Newborns and Infants
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Clubfoot
Keywords: Congenital idiopathic clubfoot
Pirani score
infant
polyaxial brace
Lead sponsor: Children's Hospital of Chongqing Medical University
Sponsor class: OTHER
First posted: 2016-06-28
Enrollment: 88
Sex: ALL
Minimum age (years): 1
Maximum age (years): 3
Standard ages: CHILD
Accepts healthy volunteers: yes
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: TREATMENT

Brief summary: Congenital idiopathic clubfoot (CC) is the fifth most common congenital malformation in children. The Ponseti method is an effective protocol for treatment of congenital idiopathic clubfoot. Plaster is essential for the Ponseti treatment. This paper describes a new brace that can be used for the treatment of clubfoot in newborns and infants instead of plaster.

Detailed description: Methods In the orthopedic department of our hospital, 38 infants and newborns, (57 feet) ,all the patients were under the age of 3 months with congenital clubfoot underwent polyaxial braces between Jan, 2011 to Oct ,2013. Polyaxial brace was used for the deformity correction. Then, during the following 1-3 years, the Dennis braces were used during the night in case of recurrence. Prospective follow-up for a mean duration of 25 months (range, 15-36months) was carried out. The efficacy of the treatment was assessed by Pirani's scoring system before and after treatment.

Eligibility criteria: Inclusion Criteria:

0-6 months infants parents would like to cooperate with the doctors.

Exclusion Criteria:

over 6 months.

Primary outcomes:
measure: hindfoot
timeFrame: 1 month
measure: midfoot
timeFrame: 1 month
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
References:
Clinical trial NCT03460106: The Development of a Screening Assay by LC-MS/MS to Monitor Adherence to Asthma Treatment
Official title: The Development of a Screening Assay by LC-MS/MS to Monitor Adherence to Asthma Treatment
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Asthma
Keywords: Asthma Medical Adherence
Lead sponsor: Heart of England NHS Trust
Sponsor class: OTHER
First posted: 2018-03-09
Enrollment: 150
Sex: ALL
Minimum age (years): 18
Maximum age (years): 80
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: CASE_ONLY
Time perspective: CROSS_SECTIONAL
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Patients will be identified at the BRSAS, general asthma clinics and as inpatients admitted to wards at HEFT. The research team will approach patients in these settings.

Brief summary: Phase I: To develop and validate laboratory urine and blood test for the detection of medications commonly used in the treatment of asthma Phase II: to test the developed assay in the clinic, to determine its practicality to conduct, and its clinical utility in adherence assessment.

Detailed description: Phase I: laboratory based study to develop LC-MS/MS assay of urine / blood to detect presence or lack asthma medication in 50 volunteers with asthma. Phase II: once the test is validated it will be tested in a 100 patients attending the asthma clinics to test its clinical utility. Urine and blood samples will be collected from patients at time of clinic attendance to test for asthma medication panel and outcome will determine adherence or non-adherence. Clinical outcomes of adherent versus non adherent groups will be compared in terms of asthma control, lung function, biomarkers FeNO and blood eosinophils, exacerbation frequency and hospitalisation.

Eligibility criteria: Inclusion Criteria:

1. Aged 18-80
2. Able to give valid informed consent
3. Prescribed one or more of the medications to be tested
4. Able to provide a blood and urine sample
5. Able to complete questionnaires in English

Exclusion Criteria:

1. Females who are pregnant or lactating.
2. Patients known to have any blood borne virus that would render the sample hazardous. This includes Hepatitis B, Hepatitis C and HIV.

Primary outcomes:
measure: To develop and validate laboratory urine and blood test for the detection of medications commonly used in the treatment of asthma
timeFrame: 4 months
Secondary outcomes:
measure: To test the developed assay in the clinic, to determine its practicality to conduct, and its clinical utility in adherence assessment.
timeFrame: 6 months
Other outcomes:
Locations:
city: Birmingham
country: United Kingdom
facility: Birmingham Heartlands Hospital
state: West Midlands
Study officials:
affiliation: Heart of England NHS Foundation Trust
name: Robert Mr Williams
role: PRINCIPAL_INVESTIGATOR
affiliation: Heart of England NHS Foundation Trust
name: Alexander Lawson Dr Lawson
role: PRINCIPAL_INVESTIGATOR
References: