Clinical trial NCT00664300: Facial Expression Recognition of Emotion and Categorization of Emotional Words in Gilles de la Tourette's Syndrome
Official title: Facial Expression Recognition of Emotion and Categorization of Emotional Words in Gilles de la Tourette's Syndrome
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Gilles de la Tourette's Syndrome
Keywords: Gilles de la Tourette's syndrome
Facial expression recognition of emotion
Frequency levels
Automatic and voluntary information treatment
Patient with Gilles de la Tourette's syndrome
Lead sponsor: University Hospital, Clermont-Ferrand
Sponsor class: OTHER
First posted: 2008-04-22
Enrollment: 60
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Sampling method: PROBABILITY_SAMPLE
Study population: 30 patients with Gilles de la Tourette's Syndrome and 30 healthy paired volunteers (control group)

Brief summary: Gilles de la Tourette's syndrome is a childhood onset inherited neuropsychiatric disorder characterised by the presence of both multiple motor tics and one or more vocal tics (noises), with psychiatric and/or behaviour disorders (such as obsessive compulsive behaviour...).

This disease is associated with an dopamine system imbalance which could be responsible of a specific trouble in the recognition in some facial expression. This has been already shown in Gilles de la Tourette patients with obsessive compulsive behaviour.

We hypothesise that patients with Gilles de la Tourette's syndrome present a dysfunction of voluntary and automatic treatment of emotional information.

The main purpose of this study is to show if patients with Gilles de la Tourette's syndrome present a lack of specific facial expression recognition of emotion and determinate more precisely if this alteration involves the cortical way (high frequency way) or the under cortical way (low frequency way).

Detailed description: 20 patients with Gilles de la Tourette's syndrome compared to 20 healthy paired volunteers.

Study progress (patients):

Inclusion visit :

Psychiatric evaluation Psychological evaluation

Ophthalmic visit

Protocol :

Facial expression recognition test Lexical decision test

Study progress (healthy volunteers):

Psychiatric evaluation Ophthalmic visit Facial expression recognition test Lexical decision test

Eligibility criteria: Inclusion Criteria:

* Age : \>18 years
* Patient with a Gilles de la Tourette 's syndrome such as defined in the DSMIV
* Stability of treatment \>1 month
* Mini Mental State \> 26
* Affiliation to social security
* Agreement of patients

Exclusion Criteria:

* Patients with cognitive disorders, dementia, mental retardation...
* Patients with serious neurological pathologies
* Patients with a vision contrast altered.
* Patients who do not understand the words associated with an emotion
* Pregnant women
* Person who participate to an other study

Primary outcomes:
measure: Facial expression recognition test
timeFrame: % of exact responses
Secondary outcomes:
measure: Lexical decision test
timeFrame: The time to respond
Other outcomes:
Locations:
city: Clermont-Ferrand
country: France
facility: CHU
Study officials:
affiliation: University Hospital, Clermont-Ferrand
name: Isabelle Jalenques, PUPH
role: PRINCIPAL_INVESTIGATOR
References: