Clinical trial NCT03095677: Acute and Chronic Effects of Dynamic Apnea in Healthy Untrained Subjects
Official title: Acute and Chronic Effects of Dynamic Apnea in Healthy Untrained Subjects
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Apnea
Keywords: dynamic apnea
muscle oxygenation
physical performance
Lead sponsor: Centre Hospitalier Régional d'Orléans
Sponsor class: OTHER
Collaborators: name: Laboratoire de Complexité, Innovation et Activités Motrices et Sportives
First posted: 2017-03-30
Enrollment: 25
Sex: MALE
Minimum age (years): 18
Maximum age (years): 40
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: BASIC_SCIENCE

Brief summary: The inclusion of short periods of apnea (several seconds) during exercise (i.e. dynamic apnea) induces a significant decrease in blood oxygenation and muscle tissue. To date, the immediate effects ("acute apnea") of this decrease in the quantity of oxygen available at the muscle and brain level are poorly understood. Moreover, a physical training during which these short periods of apnea ("chronic apnea") would be included could lead to physiological adaptations and to improvement in physical performance similar to those obtained during altitude training.

The purpose of this study is to evaluate the effects of acute dynamic apnea on metabolism.


Eligibility criteria: Inclusion Criteria:

* The cutaneous thickness at the vastus lateralis level lower than 1.5 cm to obtain the reliable muscle oxygenation measurement
* Subjects will have to sign the inform consent before the beginning of the study

Exclusion Criteria:

* Contraindications to regular physical exercise practice
* To practice an endurance sport more than 1h/week
* Regular practice of apnea
* Chronic use of cannabis and/or alcohol
* Cardiac or metabolic pathology
* Asthma and/or bronchodilatator treatment
* ECG abnormality at rest
* Regular consumption of tobacco

Primary outcomes:
measure: Spectometry to measure hemoglobin rate
timeFrame: 3 weeks
measure: Wingate test to measure maximum consumption of dioxygen
timeFrame: 3 weeks
measure: Measurement of hormonal markers
timeFrame: 3 weeks
measure: Jaeger debimeter system to measure of peak oxygen
timeFrame: 3 weeks
measure: Measurement of arterial saturation in dioxygen
timeFrame: 3 weeks
measure: Spectometry to measure hemoglobin
timeFrame: 12 weeks
measure: Measurement of hormonal markers
timeFrame: 12 weeks
measure: Jaeger debimeter system to measure of peak oxygen
timeFrame: 12 weeks
measure: Measurement of arterial saturation in dioxygen
timeFrame: 12 weeks
Secondary outcomes:
measure: Cardiac frequency
timeFrame: 3 weeks
measure: Cardiac frequency
timeFrame: 12 weeks
measure: Borg scale to measure penibility of the effort
timeFrame: week 3
measure: Borg scale to measure penibility of the effort
timeFrame: week 12
Other outcomes:
Locations:
city: Orléans
country: France
facility: CHR d'Orléans
Study officials:
affiliation: CHR ORLEANS
name: Virgile AMIOT, Ph
role: PRINCIPAL_INVESTIGATOR
References:
citation: Andersson JP, Liner MH, Runow E, Schagatay EK. Diving response and arterial oxygen saturation during apnea and exercise in breath-hold divers. J Appl Physiol (1985). 2002 Sep;93(3):882-6. doi: 10.1152/japplphysiol.00863.2001.
citation: Caquelard F, Burnet H, Tagliarini F, Cauchy E, Richalet JP, Jammes Y. Effects of prolonged hypobaric hypoxia on human skeletal muscle function and electromyographic events. Clin Sci (Lond). 2000 Mar;98(3):329-37.
citation: de Bruijn R, Richardson M, Schagatay E. Increased erythropoietin concentration after repeated apneas in humans. Eur J Appl Physiol. 2008 Mar;102(5):609-13. doi: 10.1007/s00421-007-0639-9. Epub 2007 Dec 19.
citation: Dufour SP, Ponsot E, Zoll J, Doutreleau S, Lonsdorfer-Wolf E, Geny B, Lampert E, Fluck M, Hoppeler H, Billat V, Mettauer B, Richard R, Lonsdorfer J. Exercise training in normobaric hypoxia in endurance runners. I. Improvement in aerobic performance capacity. J Appl Physiol (1985). 2006 Apr;100(4):1238-48. doi: 10.1152/japplphysiol.00742.2005.