Clinical trial NCT06437145: Acute Effects of HIIT vs. MICT on HRV
Official title: Acute Effects of High Intensity Interval Training (HIIT) vs. Moderate Intensity Continuous Training (MICT) on Heart Rate Variability Parameters in Patients After Myocardial Infarction
Study type: INTERVENTIONAL
Overall status: RECRUITING
Phase: NA
Conditions: Myocardial Infarction
Keywords: exercise training
high intensity interval training
moderate intensity continuous training
heart rate variability
myocardial infarction
Lead sponsor: University Medical Centre Ljubljana
Sponsor class: OTHER
First posted: 2024-05-31
Enrollment: 20
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: CROSSOVER
Intervention model description: Each patient will have a bout of HIIT during one session and a bout of MICT during another session performed in a random order.
Primary purpose: TREATMENT

Brief summary: Heart rate variability (HRV) is impaired in patients after myocardial infarction. Most studies so far have proved chronic beneficial effects of different types of exercise on HRV parameters. Data on acute effects of different types of exercise training (e.g. high intensity interval training \[HIIT\] and moderate intensity continuous training \[MICT\]) is scarce.

Patients in the study will perform both HIIT and MICT in a random order and in-between break of at least 48 hours. A 5-minute high resolution ECG recording will be performed before and immediately after both HIIT and MICT.


Eligibility criteria: Inclusion Criteria:

* myocardial infarction in last 120 days
* sinus rhythm

Exclusion Criteria:

* contraindications for exercise training
* uncontrolled dysrhythmias
* Heart Failure NYHA IV stage
* cognitive impairment
* pregnancy

Primary outcomes:
measure: HF parameter
timeFrame: 5-minutes high resolution ECG recording before and after an exercise session
Secondary outcomes:
measure: LF parameter
timeFrame: 5-minutes high resolution ECG recording before and after an exercise session
measure: SDNN
timeFrame: 5-minutes high resolution ECG recording before and after an exercise session
measure: RMSSD
timeFrame: 5-minutes high resolution ECG recording before and after an exercise session
measure: pNN50
timeFrame: 5-minutes high resolution ECG recording before and after an exercise session
Other outcomes:
measure: Non-linear methods
timeFrame: 5-minutes high resolution ECG recording before and after an exercise session
Locations:
city: Ljubljana
country: Slovenia
facility: University Medical Centre Ljubljana
Study officials:
affiliation: University Medical Centre Ljubljana
name: Marko Novaković, MD, PhD
role: STUDY_CHAIR
References:
citation: Routledge FS, Campbell TS, McFetridge-Durdle JA, Bacon SL. Improvements in heart rate variability with exercise therapy. Can J Cardiol. 2010 Jun-Jul;26(6):303-12. doi: 10.1016/s0828-282x(10)70395-0.
citation: El-Malahi O, Mohajeri D, Mincu R, Bauerle A, Rothenaicher K, Knuschke R, Rammos C, Rassaf T, Lortz J. Beneficial impacts of physical activity on heart rate variability: A systematic review and meta-analysis. PLoS One. 2024 Apr 5;19(4):e0299793. doi: 10.1371/journal.pone.0299793. eCollection 2024.
citation: Grassler B, Thielmann B, Bockelmann I, Hokelmann A. Effects of different exercise interventions on heart rate variability and cardiovascular health factors in older adults: a systematic review. Eur Rev Aging Phys Act. 2021 Nov 17;18(1):24. doi: 10.1186/s11556-021-00278-6.