Clinical trial NCT05774847: Unconscious Processing in Decision-making
Official title: Behavioral Evidence on the Modulators of Unconscious Processing in Decision-making
Study type: OBSERVATIONAL
Overall status: RECRUITING
Conditions: Healthy Volunteers
Keywords: decision-making
unconscious processing
subliminal processing
Lead sponsor: Istituti Clinici Scientifici Maugeri SpA
Sponsor class: OTHER
Collaborators: name: Istituto Universitario di Studi Superiori Pavia
First posted: 2023-03-20
Enrollment: 200
Sex: ALL
Minimum age (years): 18
Maximum age (years): 60
Standard ages: ADULT
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: 200 healty individuals, aged 18-60 years, sampled from the general population

Brief summary: This behavioral study on healthy participants aims to provide a baseline reference for assessing alterations of decision-making performance in pathological conditions. To this purpose, this single center non-interventional behavioral study will assess the extent to which decision-making performance is affected by distinct experimental manipulations, as well as by ageing effects, in 200 healthy individuals. The main questions it aims to answer are:

* to what extent is decision-making performance stable, within individuals, regardless of non-economic manipulations concerning stimuli perceptual features as well as type of processing and motor response required to participants?
* are these manipulations additionally influenced by participants' age?

Healthy participants will be recruited for distinct behavioral studies assessing the effects of the aforementioned manipulations of distinct metrics of decision-making performance, such as loss aversion, risk aversion, and delay discounting.

Detailed description: The fast growth of so-called Decision Neuroscience has clearly shown the implications of methods and results from behavioral economics as a potential bridge for translational research in neuro-psychiatric settings. The combination of behavioral and neural metrics allows to describe decision-making across multiple levels of explanation ranging from biological dispositions to contextual influences. To date, however, the translational implications of Decision Neuroscience are constrained by a relatively limited knowledge of the potential modulators of decision-making, which seem to include perceptual, cognitive and motor variables. In this regard, there is largely sparse evidence concerning the modulation of choices by highly different factors such as a) perceptual features of the stimuli (e.g., spatial distance between visually-presented potential gains and losses); b) type of processing required to participants (e.g., select vs. reject an option); c) type of motor response required to communicate the decision (e.g., press vs. release a button); d) subliminal vs. supraliminal perception of the stimuli. Moreover, there is evidence of ageing effects on decision-making, particularly when choice-related evaluations involve a trade-off between reward and risk. On this ground, this single center non-interventional behavioral study aims to investigate whether, and how, distinct well-established metrics of decision-making are influenced by the aforementioned factors. To this purpose, 200 healthy individuals will be recruited and assigned to different behavioral studies aimed to assess the effect of the aforementioned manipulations on well-established gambling tasks resulting in individual metrics of loss aversion (the tendency to prefer avoiding losses to acquiring equivalent gains), risk aversion (the preference for certain outcomes over probabilistic ones), and delay discounting (the decline in the present value of a reward with delay to its receipt). The results of this study are expected to provide a baseline reference for assessing alterations of decision-making performance in pathological conditions.

Eligibility criteria: Inclusion Criteria:

* Healthy participants, as determined by screening assessments and principal investigator judgment
* The participant must be able to comply with study requirements as judged by the principal investigator

Exclusion Criteria:

* Any history of alcohol and/or drug abuse, addiction or suspicion of regular consumption of drugs of abuse
* Use of any psychoactive medication, or medications known to have effect on central nervous system

Primary outcomes:
measure: Individual index of loss aversion
timeFrame: Behavioral-study day 1
Secondary outcomes:
measure: Individual index of risk aversion
timeFrame: Behavioral-study day 1
measure: Individual index of delay discounting
timeFrame: Behavioral-study day 1
Other outcomes:
Locations:
city: Pavia
country: Italy
facility: Istituti Clinici Scientifici Maugeri SpA
state: Ita
Study officials:
References: