Clinical trial NCT06543706: Metabolic Syndrome and Related Diseases in Healthcare Workers
Official title: Metabolic Syndrome and Its Related Diseases in Healthcare Workers: Incidence, Prevalence, and Risk Factors
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Metabolic Syndrome X
Diabetes Mellitus Type 2
Hypertension
Hyperlipidemia
Obesity
Cardiovascular Diseases
Stroke
Keywords: metabolic syndrome
metabolic related diseases
medical workers
Lead sponsor: Peking Union Medical College Hospital
Sponsor class: OTHER
First posted: 2024-08-09
Enrollment: 7432
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: COHORT
Time perspective: RETROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Healthcare workers who were working in the hospital, including those who have retired from the hospital

Brief summary: This study aims to investigate the incidence and prevalence of metabolic syndrome and metabolism-related diseases among healthcare workers, identify potential risk factors for these diseases, evaluate the control status of these conditions, and explore the significance of annual regular check-ups in improving metabolic-related health outcomes. All data for the study subjects are sourced from anonymized continuous records in hospital physical examinations and medical case files. The study does not involve any interventions. Upon obtaining the study data, researchers will use retrospective analysis methods to identify possible associations between risk factors and diseases.


Eligibility criteria: Inclusion Criteria:

* Age ≥18 years
* Healthcare workers who attend annual check-ups at Peking Union Medical College Hospital

Exclusion Criteria:

* Presence of metabolic syndrome, hypertension, diabetes, coronary heart disease, or stroke at the time of the first physical examination between 2012 and 2022
* Malignant neoplasm
* Uremia
* Liver failure
* Moderate to severe heart failure

Primary outcomes:
measure: composite endpoint of cardiovascular and cerebrovascular diseases
timeFrame: through study completion, an average of 5 years
Secondary outcomes:
measure: new-onset metabolic syndrome
timeFrame: through study completion, an average of 5 years
Other outcomes:
Locations:
city: Beijing
country: China
facility: Tengda Xu
state: Beijing
Study officials:
affiliation: Department of Health, Peking Union Medical College Hospital
name: Tengda Xu
role: PRINCIPAL_INVESTIGATOR
References:
citation: Strauss M, Lavie CJ, Lippi G, Brzek A, Vollenberg R, Sanchis-Gomar F, Leischik R. A systematic review of prevalence of metabolic syndrome in occupational groups - Does occupation matter in the global epidemic of metabolic syndrome? Prog Cardiovasc Dis. 2022 Nov-Dec;75:69-77. doi: 10.1016/j.pcad.2022.09.003. Epub 2022 Sep 23.
citation: Liu J, Liu Q, Li Z, Du J, Wang C, Gao Y, Wei Z, Wang J, Shi Y, Su J, Liu Y, Wang P, Xie C, Li G, Shao B, Zhang L. Prevalence of Metabolic Syndrome and Risk Factors Among Chinese Adults: Results from a Population-Based Study - Beijing, China, 2017-2018. China CDC Wkly. 2022 Jul 22;4(29):640-645. doi: 10.46234/ccdcw2022.138.
citation: Xi B, He D, Hu Y, Zhou D. Prevalence of metabolic syndrome and its influencing factors among the Chinese adults: the China Health and Nutrition Survey in 2009. Prev Med. 2013 Dec;57(6):867-71. doi: 10.1016/j.ypmed.2013.09.023. Epub 2013 Oct 5.