Clinical trial NCT00498199: Visual Impairment, Oscillopsia and Multiple Sclerosis
Official title: Visual Impairment, Oscillopsia and Multiple Sclerosis
Study type: OBSERVATIONAL
Overall status: TERMINATED
Conditions: Multiple Sclerosis
Keywords: Multiples sclerosis
oscillopsia
eye movements
motion detection
retinal slip
nystagmus
Lead sponsor: Hospices Civils de Lyon
Sponsor class: OTHER
First posted: 2007-07-09
Enrollment: 100
Sex: ALL
Minimum age (years): 18
Maximum age (years): 90
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: Patients with established multiple sclerosis

Brief summary: This study consists of two parts. The first part is a survey to examine vision-specific health-related quality of life in a cohort of patients with multiple sclerosis. We test visual impairment like visual acuity, visual field, colour discrimination, contrast sensitivity, eye movement. The aim of this part is to examine the association between responses to the quality of life scale and objective measures of visual impairment.

The second part is an open controlled study, in which we measure motion detection threshold in MS patients with oscillopsia due to pendular nystagmus and in a group of control subjects. The objective of this part is to determine whether patients with pendular nystagmus develop adaptation to oscillopsia using increased threshold of motion detection. We plan to test the effect of visuo-motor rehabilitation on this threshold in patients with oscillopsia due to pendular nystagmus.

Detailed description: In the first part, 100 patients with multiple sclerosis are included. A vision-specific health-related quality of life scale and neuro-ophthalmological tests are administered. The duration of intervention is about 3 hours by patient and one year to finish this part.

In the second part, we include about 40 of 100 MS patients who present an oscillopsia due to pendular nystagmus and a group of 20 control subjects. The patients and subject will perform a motion detection task and the vision-specific health-related quality of life, the intervention lasting 1 hour. Then the patients will be randomized in one group treated by rehabilitation (one 30 mn session per week during 3 months) and the other one without treatment. A motion detection task and the vision-specific health-related quality of life scale will be performed at the end of the treatment for both groups.

Eligibility criteria: Inclusion Criteria:

* Age 18 to 90
* Patients with established multiple sclerosis
* Visual impairment recovering from MS
* Understanding rules task
* Patient can stay set a long time
* Patient's agreement
* Membership to the Social Security
* No relapsing since three months

Exclusion Criteria:

* Brain damage
* Cognitive or behaviour disorder
* Patients with peripheral vestibular, otologic or ophthalmologic pathology antecedent
* Not stabilized disease (other one than MS)
* Patient under guardianship

Primary outcomes:
Secondary outcomes:
Other outcomes:
Locations:
city: Lyon
country: France
facility: Caroline Tilikete
Study officials:
affiliation: Hospices Civils de Lyon
name: Caroline Tilikete, MD
role: PRINCIPAL_INVESTIGATOR
References: