Clinical trial NCT04553653: Improving Acute Hypertension Management Through Emergency Department Checklist
Official title: Improving Acute Hypertension Management Through Emergency Department Checklist
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Hypertension
Hypertensive Crisis
Hypertensive Emergency
Keywords: checklist
emergency department
Lead sponsor: Johns Hopkins University
Sponsor class: OTHER
Collaborators: name: Aga Khan University
name: Fogarty International Center of the National Institute of Health
First posted: 2020-09-17
Enrollment: 1161
Sex: ALL
Minimum age (years): 25
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NON_RANDOMIZED
Intervention model: SEQUENTIAL
Intervention model description: This will be a before-after study. Baseline data capturing care and the outcomes of patients presenting with acute severe hypertension will be collected. A checklist will be developed and implemented and a post-implementation data collection will be conducted using the same tool as prior to the intervention.
Primary purpose: TREATMENT

Brief summary: The investigators hypothesize that the implementation of a checklist in acute severe hypertension would result in improving short and long-term outcomes of patients with acute severe hypertension treated in the emergency department (ED). The investigators hypothesize that in the short-term, a checklist would improve the diagnosis and management of end-organ damage as well as reduce the length of stay of acute severe hypertensive patients in the ED. The investigators hypothesize that the checklist will result in better compliance with anti-hypertensive medications than without the checklist at six-month post-discharge.

Detailed description: Hypertension is a global public health issue and results in over 10 million deaths every year. The disease affects one-third of people living in low- and middle-income countries (LMICs) and contributes to half of all productivity losses in LMICs due to non-communicable diseases. Though hypertension often presents as a chronic asymptomatic illness, hypertension-related emergencies represent a significant burden to the health care system. Acute severe hypertension \[i.e., systolic blood pressure (SBP) ≥ 180 mmHg or diastolic blood pressure (DBP) ≥ 110 mmHg\] make up to 5% of all emergency admission. One-third of these patients present with end-organ damage; a condition called a hypertensive crisis. More worrisome is the fact that a number of ED visits, as a result, severe acute hypertension and hypertensive crises have almost tripled between 2006 and 2013 in the US. Treatment approaches to managing acute severe hypertension (\~5% of ED patients) are largely unclear and only 6% of ED patients with acute severe hypertension receive appropriate work-up for the end-organ damage, indicating a huge care gap. One approach, which has been used successfully in managing other complex and critical conditions, is the use of checklists. Checklists are a listing of actions to be performed in a given clinical setting with the aim of improving adherence to standards, reducing errors and thus improving patient outcomes. The investigators hypothesize that the use of a Checklist, if appropriately implemented, can lead to an improvement in the care of patients presenting with hypertensive crisis. During this study, the investigators will measure the prevalence of acute severe hypertension and assess the current quality of care for these patients. This will be followed by the development of a checklist for the management of the hypertensive crises in the ED. The investigators will follow these patients to see the impact of the checklist on the quality of care and long-term outcomes.

Eligibility criteria: Inclusion Criteria:

* Adults who visit the Aga Khan University Hospital Emergency Department with acute severe hypertension
* able to provide consent to participate
* Age \>25 years of age
* Meeting the criteria of acute severe hypertension (SBP\>180 and DBP\>110).

Exclusion Criteria:

* Patients not providing consent or are unconscious are excluded from participation.

Primary outcomes:
measure: Change in frequency of diagnosis of hypertensive emergency
timeFrame: Baseline and 6 months after checklist implementation
Secondary outcomes:
measure: Change in the use of appropriate medications for treatment of hypertensive emergency
timeFrame: Baseline and 6 months after checklist implementation
Other outcomes:
measure: Compliance with chronic treatment of hypertension as assessed through a phone call
timeFrame: Up to 6 months post discharge from the emergency department
Locations:
city: Karachi
country: Pakistan
facility: Aga Khan University
Study officials:
affiliation: Johns Hopkins University
name: Junaid A Razzak
role: PRINCIPAL_INVESTIGATOR
References: