Clinical trial NCT05501249: Aquatic Exercise for Cognition and Mobility in Older Adults
Official title: Effects of Aquatic Integrated Cognitive Motor Training on Cognition and Mobility in Older Adults
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Aging Well
Aging Problems
Cognitive Change
Gait, Unsteady
Mobility Limitation
Keywords: Aquatic exercise
Fall prevention
Functional mobility
Lead sponsor: University of Texas at Austin
Sponsor class: OTHER
First posted: 2022-08-15
Enrollment: 25
Sex: ALL
Minimum age (years): 65
Standard ages: OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: PREVENTION

Brief summary: The purpose of this study is to assess the effects of an aquatic exercise program on cognition and physical function of older adults.


Eligibility criteria: Inclusion Criteria:

* Able to ambulate 100 ft independently with or without assistive device
* Score greater than or equal to 3 on the Mini-Cog Test
* Stable medical condition within one month prior to the study
* Stable exercise program within one month prior to the study
* Available during study testing and group class times
* COVID-19 vaccination
* Permission from medical provider to participate in the study

Exclusion Criteria:

* History of dementia or Alzheimer's
* Contraindication to exercise or pool immersion (e.g., unstable cardiovascular conditions, fever, diarrhea, aqua-phobia)

Primary outcomes:
measure: Stroop Effect Test: Change from baseline to the end of intervention/control period
timeFrame: Measures taken at baseline and again at approximately 9-10 weeks
measure: Trail Making Test A and B: Change from baseline to the end of intervention/control period
timeFrame: Measures taken at baseline and again at approximately 9-10 weeks
measure: Digit Backwards Test : Change from baseline to the end of intervention/control period
timeFrame: Measures taken at baseline and again at approximately 9-10 weeks
measure: Gait Measurements: Change from baseline to the end of intervention/control period
timeFrame: Measures taken at baseline and again at approximately 9-10 weeks
measure: Functional Outcome Measures: Change from baseline to the end of intervention/control period
timeFrame: Measures taken at baseline and again at approximately 9-10 weeks
Secondary outcomes:
measure: Vital Sign measurements: Change from baseline to the end of intervention/control period
timeFrame: Measures taken at baseline and again at approximately 9-10 weeks
measure: Anthropometric measurements: Change from baseline to the end of intervention/control period
timeFrame: Measures taken at baseline and again at approximately 9-10 weeks
measure: Neurotrophic Growth Factors: Change from baseline to the end of intervention/control period
timeFrame: Measures taken at baseline and again at approximately 9-10 weeks
measure: Numeric Pain Rating Scale: Change from baseline to the end of intervention/control period
timeFrame: Measures taken at baseline and again at approximately 9-10 weeks
measure: Global Rating of Change Questionnaire: Change from baseline to the end of intervention/control period
timeFrame: Measures taken at baseline and again at approximately 9-10 weeks
measure: Activities-specific balance confidence scale: Change from baseline to the end of intervention/control period
timeFrame: Measures taken at baseline and again at approximately 9-10 weeks
Other outcomes:
Locations:
city: Austin
country: United States
facility: The University of Texas at Austin
state: Texas
Study officials:
affiliation: The University of Texas at Austin
name: Emily Dunlap, BS
role: PRINCIPAL_INVESTIGATOR
References:
citation: Carter HH, Spence AL, Pugh CJ, Ainslie P, Naylor LH, Green DJ. Cardiovascular responses to water immersion in humans: impact on cerebral perfusion. Am J Physiol Regul Integr Comp Physiol. 2014 May;306(9):R636-40. doi: 10.1152/ajpregu.00516.2013. Epub 2014 Feb 19.
citation: Bressel E, Louder TJ, Raikes AC, Alphonsa S, Kyvelidou A. Water Immersion Affects Episodic Memory and Postural Control in Healthy Older Adults. J Geriatr Phys Ther. 2019 Oct/Dec;42(4):E1-E6. doi: 10.1519/JPT.0000000000000192.
citation: Parfitt R, Hensman MY, Lucas SJE. Cerebral Blood Flow Responses to Aquatic Treadmill Exercise. Med Sci Sports Exerc. 2017 Jul;49(7):1305-1312. doi: 10.1249/MSS.0000000000001230.
citation: Pugh CJ, Sprung VS, Ono K, Spence AL, Thijssen DH, Carter HH, Green DJ. The effect of water immersion during exercise on cerebral blood flow. Med Sci Sports Exerc. 2015 Feb;47(2):299-306. doi: 10.1249/MSS.0000000000000422.
citation: Kang DW, Bressel E, Kim DY. Effects of aquatic exercise on insulin-like growth factor-1, brain-derived neurotrophic factor, vascular endothelial growth factor, and cognitive function in elderly women. Exp Gerontol. 2020 Apr;132:110842. doi: 10.1016/j.exger.2020.110842. Epub 2020 Jan 15.
citation: Commandeur D, Klimstra MD, MacDonald S, Inouye K, Cox M, Chan D, Hundza SR. Difference scores between single-task and dual-task gait measures are better than clinical measures for detection of fall-risk in community-dwelling older adults. Gait Posture. 2018 Oct;66:155-159. doi: 10.1016/j.gaitpost.2018.08.020. Epub 2018 Aug 23.
citation: de Assis GG, de Almondes KM. Exercise-dependent BDNF as a Modulatory Factor for the Executive Processing of Individuals in Course of Cognitive Decline. A Systematic Review. Front Psychol. 2017 Apr 19;8:584. doi: 10.3389/fpsyg.2017.00584. eCollection 2017.
citation: Doi T, Shimada H, Makizako H, Tsutsumimoto K, Hotta R, Nakakubo S, Suzuki T. Association of insulin-like growth factor-1 with mild cognitive impairment and slow gait speed. Neurobiol Aging. 2015 Feb;36(2):942-7. doi: 10.1016/j.neurobiolaging.2014.10.035. Epub 2014 Nov 1.
citation: Nissim M, Hutzler Y, Goldstein A. A walk on water: comparing the influence of Ai Chi and Tai Chi on fall risk and verbal working memory in ageing people with intellectual disabilities - a randomised controlled trial. J Intellect Disabil Res. 2019 Jun;63(6):603-613. doi: 10.1111/jir.12602. Epub 2019 Feb 18.
citation: Sato D, Seko C, Hashitomi T, Sengoku Y, Nomura T. Differential effects of water-based exercise on the cognitive function in independent elderly adults. Aging Clin Exp Res. 2015 Apr;27(2):149-59. doi: 10.1007/s40520-014-0252-9. Epub 2014 Jun 26.