louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT05857813: Establishment of Social Skills Training Group in Adolescents With Autism Spectrum Disorder and Effectiveness Analysis
Official title: Establishment of Social Skills Training Group in Adolescents With Autism Spectrum Disorder and Effectiveness Analysis
Study type: INTERVENTIONAL
Overall status: RECRUITING
Phase: NA
Conditions: Autism Spectrum Disorder
Lead sponsor: National Taiwan University Hospital
Sponsor class: OTHER
First posted: 2023-05-15
Enrollment: 120
Sex: ALL
Minimum age (years): 11
Maximum age (years): 20
Standard ages: CHILD
ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: TREATMENT

Brief summary: Autism spectrum disorders (ASD) is a neurodevelopmental disorder characterized by persistent deficits in social communication and social interaction across multiple contexts, and the presence of restricted, repetitive behavior and interests, affecting 1 in 68 children. Although atypical social deficits onset in early childhood, their social relationships with peers may remain a challenge or even worsen for individuals with ASD throughout the school years and beyond, as social contexts increase in complexity and pose higher social expectations.


Eligibility criteria: Inclusion Criteria:

* aged 11-20 years, currently enrolled in school between the sixth grade of elementary school and the third year of high school
* with a clinical diagnosis of ASD from a licensed mental health or medical professional based on DSM-5
* experiencing social difficulties as reported by parents in a structured intake interview
* scored ≧ 26 on the caregiver-reported Autism Spectrum Quotient (AQ), indicating clinical impairment associated with ASD
* demonstrating verbal fluency in Chinese
* with a full-scale IQ \> 70 on WAIS-IV
* with motivation to participate in the intervention;
* with a caregiver who was fluent in Chinese and willing to participate as a social coach in the study.

Exclusion Criteria:

* a history of major mental illness (e.g., bipolar affective disorder, schizophrenia, or psychosis) or neurological diseases that might hinder participation in the treatment
* visual impairment and/or hearing impairment that would preclude participation in group-based social activities.

Primary outcomes:
measure: Autism Diagnostic Interview-Revised (ADI-R)
timeFrame: 7 weeks
measure: The Autism Diagnostic Observation Schedule (ADOS)
timeFrame: 7 weeks
measure: Autism Spectrum Quotient (AQ)
timeFrame: 7 weeks
measure: Friendship Quality Scale (FQS)
timeFrame: 7 weeks
measure: The Assessing Emotions Scale (AES)
timeFrame: 7 weeks
measure: Social Responsiveness Scale (SRS)
timeFrame: 7 weeks
measure: Social Adjustment Inventory for Children and Adolescents (SAICA)
timeFrame: 7 weeks
measure: Quality of Play Questionnaire (QPQ)
timeFrame: 7 weeks
measure: Test of Adolescents Social Skills Knowledge (TASSK)
timeFrame: 7 weeks
measure: Empathy Quotient (EQ)
timeFrame: 7 weeks
measure: Friendship Questionnaire (FQ)
timeFrame: 7 weeks
Secondary outcomes:
Other outcomes:
Locations:
city: Taipei
country: Taiwan
facility: National Taiwan University Hospital
Study officials:
References:
Clinical trial NCT04894513: Electro Physiological Responses to Kabat Motor Control Re-education on Bell's Palsy: A Randomized Controlled Study
Official title: Electro Physiological Responses to Kabat Motor Control Re-education on Bell's Palsy: A Randomized Controlled Study
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Facial Nerve Palsy
Bell's Palsy
Lead sponsor: October 6 University
Sponsor class: OTHER
First posted: 2021-05-20
Enrollment: 30
Sex: ALL
Minimum age (years): 12
Maximum age (years): 16
Standard ages: CHILD
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Intervention model description: control group which received conventional selected program, and study group received the same exercise training program in addition to Kabat motor control re-education therapy
Primary purpose: TREATMENT

Brief summary: To investigate the Effect of Kabat motor control re-education therapy on facial nerve Electro physiological responses and facial muscles function in bell's palsy.

BACKGROUND: facial nerve recovery in children could be improved through facilitation of nerve regeneration which can be enhanced through Kabat motor control re-education therapy.

Detailed description: Thirty children with bell's palsy will participate in this study. The patients will randomly be divided into two equal groups; the control group received the conventional selected program, and the study group received the same exercise training program in addition to Kabat motor control re-education therapy. The program of treatment will be three times per week for six weeks.

The evaluation methods: Facial nerve distal latency, amplitude, and percentage of degenerations via the Neuropack S1 MEB9004 EMG device, the Facial Disability Index, and Sunnybrook facial grading system (SBFGS) all the assessment methods before the program and after finishing the program

Eligibility criteria: Inclusion Criteria:

* Thirty child diagnosed as acquired bell's palsy with unilateral peripheral facial paralysis
* Both gender
* Their age ranged from 12:16 years old.

Exclusion Criteria:

* difficulty to communicate or to understand program instructions
* Oral dentures, Skin infection and metal implants on face
* Sensory loss over the face, Recurrent facial paralysis
* any other disorders or neurological deficits,
* a history of surgical intervention for the ear and facial nerve palsy
* pain of any other origin
* non co-operative patients

Primary outcomes:
measure: Electroneurography
timeFrame: 6 weeks
measure: Electroneurography
timeFrame: 6 weeks
measure: Electroneurography
timeFrame: 6 weeks
Secondary outcomes:
measure: Sunnybrook facial grading system (SBFGS)
timeFrame: 6 weeks
Other outcomes:
Locations:
city: Al Jīzah
country: Egypt
facility: Lama S Mahmoud
state: Select State
Study officials:
References:
Clinical trial NCT03260413: Pneumonia Chart Review Cambodia
Official title: Quantifying the Burden of Hospitalizations for Pneumonia Among Children in Rural
Study type: OBSERVATIONAL
Overall status: WITHDRAWN
Conditions: Pneumonia
Lead sponsor: University of Minnesota
Sponsor class: OTHER
First posted: 2017-08-24
Enrollment: 0
Sex: ALL
Minimum age (years): 1
Maximum age (years): 5
Standard ages: CHILD
Accepts healthy volunteers: no
Observational model: CASE_ONLY
Time perspective: RETROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: The study population will be children between the ages of 1 month and 5 years who were admitted to Chenla Children's Healthcare with at least one admitting diagnosis being "pneumonia" or "bronchiolitis". These children will be residents of Kratie province, Cambodia. They are admitted to Chenla Children's Healthcare by way of their emergency department.

Brief summary: This study aims to answer the question of what is the burden of lower respiratory disease (pneumonia) among children ages 1 month to 5 years of age in rural Cambodia. The primary objective will be to quantify the prevalence of severe pneumonia at Chenla Children's Healthcare, a hospital in the rural town of Kratie, Cambodia. This will involve a chart review of the medical records available at Chenla Children's Healthcare.


Eligibility criteria: Inclusion Criteria:

* Children between the ages of 1 month and 5 years admitted to Chenla Children's Healthcare with at least one admitting diagnosis being pneumonia or bronchiolitis will be included.

Exclusion Criteria:

* Children who do not fall into the aforementioned age range and who do not have "pneumonia" or "bronchiolitis" as one of the admitted diagnoses.

Primary outcomes:
measure: Pneumonia count
timeFrame: 5-6 months
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
References:
Clinical trial NCT04439513: Dual Artery Compression vs. Radial Artery-Only Hemostasis: Impact on Radial Artery Occlusion (EASY-RAO)
Official title: Randomized Comparison f Dual Artery Compression Versus Radial Artery-Only Hemostasis: Impact on Radial Artery Occlusion (EArly Discharge After Transradial Stenting of coronarY Arteries - EASY-RAO)
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Radial Artery Injury
Keywords: RAO
Hemostasis
TRA
Lead sponsor: Laval University
Sponsor class: OTHER
First posted: 2020-06-19
Enrollment: 100
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: PREVENTION

Brief summary: This study aims to demonstrate the superiority in clinical performances of a dual artery compression device (Terry-2 band) compared to a standard radial artery-only hemostasis device (HemoSTOP).


Eligibility criteria: Inclusion Criteria:

* any patients referred for diagnostic angiography and possible percutaneous coronary intervention (PCI)

Exclusion Criteria:

* Patient unable to understand study design or objectives
* Unable to sign informed consent
* Patient taking warfarin or other anticoagulant therapy
* Chronic RAO on both sides precluding TRA
* Previous ipsilateral transradial approach
* Inability to comply with the study follow-up
* Presence of plethysmographic waveform with radial and ulnar occlusive compression
* Pre-existing local complication (i.e. hematoma, pseudo-aneurysm, ...) precluding access-site evaluation.

Primary outcomes:
measure: Rate of RAO after transradial approach (TRA) at hospital discharge
timeFrame: up to 24 hours
Secondary outcomes:
measure: Percentage of radial artery patent-hemostasis during hemostasis
timeFrame: throughout intervention, up to 180 minutes
measure: Patient comfort during hemostasis as assessed on a visual scale
timeFrame: throughout intervention, up to 30 days
measure: Rates of complications such as repeat bleeding and hematoma (EASY Scale)
timeFrame: throughout intervention, up to 30 days
measure: Nursing involvement in hemostasis management for sensitivity analysis on cost assessment
timeFrame: throughout intervention, up to 24 hours
Other outcomes:
Locations:
city: Quebec
country: Canada
facility: IUCPQ - Laval Hospital
Study officials:
References:
Clinical trial NCT05514613: Effectiveness of Reel-time Ultrasound-guided Tracheostomy and Landmark Percutaneous Dilatational Tracheostomy
Official title: Comparative Effectiveness of Reel-time Ultrasound-guided Tracheostomy and Anatomic Landmark Percutaneous Dilatational Tracheostomy: a Retrospective Cohort Study
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Tracheostomy Complication
Keywords: ultrasound guided tracheostomy
anatomic landmark tracheostomy
tracheostomy
complications
Lead sponsor: Erol Olcok Corum Training and Research Hospital
Sponsor class: OTHER
Collaborators: name: Serhat Ozciftci
First posted: 2022-08-24
Enrollment: 1
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: OTHER
Time perspective: RETROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Patients over the age of 18 who were hospitalized in the intensive care unit and underwent tracheostomy

Brief summary: This study aims to assess the impact of real-time ultrasound (US) use on complication rates and procedural success in percutaneous dilational tracheostomy (PDT) opened with forceps dilatation technique using anatomical landmarks.

Detailed description: This study, patients who were admitted to the intensive care unit of hospital and who had a tracheostomy were examined. This is a retrospective study conducted to evaluate the method used during tracheostomy and themcomplications that occurred during and after tracheostomy opening.

2852 intensive care patients hospitalized in hospital intensive care unit after obtaining ethical permission were investigated retrospectively by scanning their files and digital data, and their complications during and after tracheostomy procedures.

Eligibility criteria: Inclusion Criteria:

* Hospitalized in the intensive care unit and tracheostomy was opened and over 18 years.

Exclusion Criteria:

* surgical opened tracheostomy

Primary outcomes:
measure: Ultrasound-guided Tracheostomy and Landmark Percutaneous Dilatational Tracheostomy
timeFrame: 01.04.2017-11.03.2019
Secondary outcomes:
Other outcomes:
Locations:
city: Çorum
country: Turkey
facility: Çorum training and research state hospital
Study officials:
References:
Clinical trial NCT02649413: Adjusted Steroids Therapy in Childerens With Idiopathic Nephrotic Syndrome
Official title: Adjusted Steroid Therapy in Children With Idiopathic Nephrotic Syndrome
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: PHASE4
Conditions: Nephrotic Syndrome, Minimal Change
Lead sponsor: Rabin Medical Center
Sponsor class: OTHER
First posted: 2016-01-07
Enrollment: 75
Sex: ALL
Minimum age (years): 1
Maximum age (years): 18
Standard ages: CHILD
ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: TREATMENT

Brief summary: The initial steroids dose for Nephrotic Syndrome is 60mg/1m2 for 6-4 weeks and the duration of the first steroid course is between 8 weeks to 6 months. The base of the initial dose for steroids Idiopathic nephrotic syndrome been put in the early 70s. In our study the investigators will adjusted the first steroids does to the response day. Our primary end point is : a lower adjusted dose is as good as the fix dose in the first year after diagnosis.

Detailed description: About 90% of the patients will response to steroid therapy. The initial steroid dose is between 2mg/kg or 60mg/1m2 for 6-4 weeks and the duration of the first steroid course is between 8 weeks to 6 months. The bases of this treatment have been put in the early 70s. Since then most of the study were focused on the duration of the therapy with a results that 8-12 weeks course is as good as 6 month. Studies have showed no difference in response rate between 2mg/kg to 60m2' although the difference in the dose in young children can rich to 25%. Other retrospective analysis been show that patients who response in the first 7-9 days tend to have lass relapses than other patients. In our nephrology clinic the investigators there is ongoing clinical study on low doses of steroid therapy for relapse of nephritic syndrome with good results.

Eligibility criteria: Inclusion Criteria:

* Children who recently have been diagnosed with nephrotic syndrome.

Exclusion Criteria:

* Children with nephrotic syndrome that can not be treated with steroids.

Primary outcomes:
measure: The time until the first relapse
timeFrame: 6 months
Secondary outcomes:
measure: Number of relapse during first year
timeFrame: one year
Other outcomes:
Locations:
city: Petach-Tikva
country: Israel
facility: Shneider children Hospital Nephrology Institute
Study officials:
affiliation: Shneider children Hospital Nephrology Institute
name: Amit Dagan, Dr.
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT05324813: Examining Effects of Domain Specific Episodic Future Thinking on Cannabis Use
Official title: Examining Effects of Domain Specific Episodic Future Thinking on Cannabis Use
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Marijuana Use
Marijuana Dependence
Tobacco Use
Alcohol Use, Unspecified
Lead sponsor: Advocates for Human Potential
Sponsor class: INDUSTRY
Collaborators: name: Dartmouth College
First posted: 2022-04-12
Enrollment: 50
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The overarching goal of this online study is to compare the efficacy of six (weekly) sessions of Domain-Specific Episodic Future Thinking (DS-EFT) relative an active control condition on improving the ability to value future rewards and reducing cannabis use (grams and days of use), tobacco use, and alcohol use among.


Eligibility criteria: Inclusion Criteria:

* at least 18 or older
* reside in the U.S.
* report wanting to reduce cannabis use (4 or higher on scale of 1-10 with higher scores indicating greater desire to reduce use)
* report using cannabis at least 10 days in the last month
* report using cannabis at least 100 days in their lifetime
* Data quality checks passed

Exclusion Criteria:

-

Primary outcomes:
measure: Number of cannabis use grams
timeFrame: 1-week follow-up
measure: Number of cannabis use days
timeFrame: 1-week follow-up
Secondary outcomes:
measure: Number of tobacco use days
timeFrame: 1-week follow-up
measure: Number of alcohol use days
timeFrame: 1-week follow-up
measure: Number of tobacco use times
timeFrame: 1-week follow-up
measure: Number of alcoholic drinks
timeFrame: 1-week follow-up
measure: Rate of delay discounting
timeFrame: 1-week follow-up
Other outcomes:
Locations:
city: Sudbury
country: United States
facility: AHP Corporate Office
state: Massachusetts
Study officials:
affiliation: AHP
name: Michael J Sofis, PhD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT03239613: Postoperative Hypofractionated Intensity-modulated Radiation Therapy with Concurrent Chemotherapy in Cervical Cancer
Official title: Postoperative Hypofractionated Intensity-modulated Radiation Therapy with Concurrent Chemotherapy in Cervical Cancer: a Prospective Exploratory Trial (POHIM_CCRT Trial)
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Cervix Cancer
Radiotherapy, Adjuvant
Radiotherapy, Intensity-Modulated
Hypofractionated Dose
Chemotherapy, Concurrent
Lead sponsor: Samsung Medical Center
Sponsor class: OTHER
First posted: 2017-08-04
Enrollment: 84
Sex: FEMALE
Minimum age (years): 20
Maximum age (years): 70
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: TREATMENT

Brief summary: To investigate the acute toxicities, late toxicities, and treatment results when the early cervical cancer patients are treated by concurrent chemotherapy with hypofractionated intensity-modulated radiotherapy (2.5 Gy X 16 fractions, once a day) after radical hysterectomy.


Eligibility criteria: Inclusion Criteria:

* histologically confirmed cervical cancer
* radical hysterectomy and pelvic lymph node dissection was done
* histologically indicated adjuvant chemoradiotherapy (more than one as below)

  * positive pelvic lymph node metastasis
  * positive parametrial invasion
  * positive tumor involvement on surgical margin
* ECOG performance status 0 or 1
* Bone marrow function: granulocyte ≥1.0 x 1000/µl, platelet ≥30 x 1000/µl, hemoglobin ≥10 g/dl
* Kidney function: Creatinine \<2.0 mg/dL, Bilirubin 1.5 mg/dl

Exclusion Criteria:

* positive distant metastasis (including retroperitoneal lymph node metastasis)
* previous history of pelvic radiotherapy
* more than 3 months after radical surgery for cervical cancer
* neoadjuvant chemotherapy was done
* previous history of other carcinoma except for thyroid cancer, skin cancer, in situ carcinoma on cervix

Primary outcomes:
measure: Acute toxicities according to CTCAE v4.0
timeFrame: 3 months
Secondary outcomes:
measure: Late toxicities according to CTCAE v4.0
timeFrame: 5-years
measure: Progression free survival rate
timeFrame: 5-years
Other outcomes:
Locations:
city: Seoul
country: Korea, Republic of
facility: Samsung Medical Center
Study officials:
References:
Clinical trial NCT05239936: Urdu Version of Arthritis Impact Measurement Scales 2 Short Form:Reliability and Validity Study
Official title: Urdu Version of Arthritis Impact Measurement Scales 2 Short Form:Reliability and Validity Study Among Patients With Osteoarthritis
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Quality of Life
Keywords: AIMS2 SF
Urdu
OA
ACR
Lead sponsor: Riphah International University
Sponsor class: OTHER
First posted: 2022-02-15
Enrollment: 165
Sex: ALL
Minimum age (years): 18
Maximum age (years): 80
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: ECOLOGIC_OR_COMMUNITY
Time perspective: CROSS_SECTIONAL
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Osteoarthritis is the leading cause of pain and disability and the most common joint disorder in our general population .According to high prevalence due to increasing age it is also increasing in the upcoming years .It causes narrow joint space and degeneration of cartilage

Brief summary: In this study ,Investigators will observe the Reliability and Validity of Arthritis Impact Measurement Scale 2 Short Form translated in Urdu language in Pakistani population to check quality of life in patients suffering from Osteoarthritis.

Detailed description: The main aim of this study is to translate and culturally adapt AIMS2 SF into Urdu language and to investigate the reliability and validity of AIMS2 SF in Osteoarthritis patients among Urdu speaking Pakistani population.

The study will be completed in 5 steps such as translation ,synthesis ,back translation ,expert committee review and pre testing. The study will be a cross sectional survey .The result of the study helps to know the validity and reliability of AIMS2 SF in Urdu Version to check the quality of life .The reliability of the scale will be checked through internal consistency and test retest method .Internal consistency will be analyzed through Cronbach's alpha value to estimate whether each item of a scale is appropriate for assessing the underlying concept of its scale with 165 patients will be used.

Eligibility criteria: Inclusion Criteria:

1. Male and Female Patient age 18 years or older.
2. Diagnosed with OA of the knee , hip and hand .
3. Patients diagnosed according to ACR criteria. 4 - X-RAY scored according to Kellgren and Lawrence Classification.

Exclusion Criteria:

1 - Radiograph not older than 6 months . 2- Age less than 18 are excluded from this study.

Primary outcomes:
measure: Arthritis Impact Measurement Scale 2-Short Form
timeFrame: 1st day
Secondary outcomes:
measure: Western Ontario and McMaster Universities Arthritis Index
timeFrame: 1st day
Other outcomes:
Locations:
city: Faisalabad
country: Pakistan
facility: Ripah International University
state: Punjab
Study officials:
affiliation: Riphah International University
name: Muhammad Kashif
role: STUDY_CHAIR
References: