Clinical trial NCT04754906: Analysis of Motor Skills in Subjects Aged 55 and Over: the Role of Cognitive Abilities for Planning Movement.
Official title: Analysis of Motor Skills in Subjects Aged 55 and Over: the Role of Cognitive Abilities for Planning Movement.
Study type: OBSERVATIONAL
Overall status: RECRUITING
Conditions: Mild Cognitive Disorder
Lead sponsor: Centre Hospitalier Universitaire Dijon
Sponsor class: OTHER
First posted: 2021-02-15
Enrollment: 684
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: CASE_CONTROL
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: young subjects, elderly neurotypical subjects and elderly subjects with mild cognitive disorder

Brief summary: Falling is an event that is more frequent and severe in older age. It can lead to a loss of autonomy and a decrease in quality of life. It is therefore important to understand this phenomenon in order to better prevent it. Among the multiple risk factors associated with falling, recent research has shown a link between the decline in cognitive abilities (i.e., the mental processes that form our knowledge, such as memory) and the risk of falling. However, the impact of this cognitive decline on motor skills is still poorly understood. The purpose of this research is to study how the changes induced by aging affect motor skills. This would make it possible to take a new look at the phenomenon of falls occurring in the elderly and, in the long term, to improve the prevention and rehabilitation.


Eligibility criteria: Inclusion Criteria:

1. Neurotypical subjects group:

   * Person aged 18 to 40 years
   * Person who has given oral consent
   * Affiliated to national health insurance
   * Right-handed person
2. Group of elderly neurotypical subjects:

   * Person over 55 years of age
   * Person who has given oral consent
   * Affiliated to national health insurance
   * No cognitive problems (MMSE score \>26)
   * Right-handed person
3. Elderly mild cognitive disorder subject group:

   * Person over 55 years of age
   * Person who has given oral consent
   * Diagnosis of Mild Cognitive Disorder made by a neurologist at the Centre Mémoire Ressources et Recherche (CMRR) of the University Hospital of Dijon, following the recommendations of the National Institute for Aging and Alzheimer's Association (Albert et al., 2011) This diagnosis is based on psychometric tests, brain imaging and the evolution of cognitive disorders, including an MMSE test.
   * Right-handed person

Exclusion Criteria:

* Neurological or psychiatric history with the exception of the TCL group.
* Follow-up of drug treatment in the last three months that may affect cognitive and/or motor skills.
* Received a shoulder prosthesis on the dominant side.
* Received a hip and/or knee replacement less than a year ago.
* Disabling joint disease of the hip or knee shoulder
* Protected adults (curatorship, guardianship)
* Person deprived of their liberty b judicial or administrative decision
* Pregnant, parturient or breastfeeding woman
* Major unable to consent

Primary outcomes:
measure: Sequence 1: symmetry ratio of the finger speed profile
timeFrame: through study completion, an average of 3 years
measure: Sequence 2 : perception bias (error in degrees of angle) of dynamic subjective visual vericality
timeFrame: through study completion, an average of 3 years
measure: Sequence 3 : activation time of the focal muscles in relation to the postural muscles
timeFrame: through study completion, an average of 3 years
Secondary outcomes:
Other outcomes:
Locations:
city: Dijon
country: France
facility: Chu Dijon Bourgogne
Study officials:
References: