Clinical trial NCT05063747: Long Term Outcome in ICU Treated COVID-19: Risk Factors for 1-year Mortality
Official title: Long Term Outcome in ICU Treated COVID-19: Risk Factors for 1-year Mortality
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Covid19
Keywords: Long term outcome
Mortality
COVID-19
Risk factors
Critical care
Lead sponsor: Uppsala University
Sponsor class: OTHER
Collaborators: name: Dalarna County Council, Sweden
First posted: 2021-10-01
Enrollment: 13537
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: CASE_CONTROL
Time perspective: RETROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: The study population consists of all patients a fulfilling the eligibility criteria.

Brief summary: Mortality within one year after intensive care unit (ICU) admission with Coronavirus disease 2019 (COVID-19) will be assessed. Risk and risk factors for one year mortality in ICU patients will be compared to patients admitted to hospital with COVID-19 and general population controls.

The ICU population comprises all Swedish ICU patients with COVID-19 with at lease one year of follow up. The hospital admitted cohort comprises four hospital admitted patients with COVID-19 per ICU patient, matched on age, legal gender and region. The general population controls are matched to the ICU patients in a one to four fashion on age, legal gender and region.

ICU patients are identified in the Swedish intensive care registry. The hospital admitted patients are identified in the national patient registry and the population controls are identified in the population registry. Data on socioeconomics and income are provided by the Statistics Sweden. Data on comorbidity, medications and death are provided from the National board of health and welfare.


Eligibility criteria: Inclusion Criteria:

* Admitted to a Swedish ICU and registered in the Swedish intensive care registry with the ICD 10 diagnosis U07.1 before 1 July 2020. ICU-cohort.

or randomly selected from all patients admitted to hospital but not ICU with the ICD 10 diagnosis U07.1 in the national patient registry, matched on age, legal gender and region (four per ICU patient) before 1 July 2020. Hospital cohort.

or randomly selected from the general population (and not included in the ICU or hospital admitted cohorts), matched on age, legal gender and region (four per ICU patient)

Exclusion Criteria:

* Missing a Swedish personal identification number

Primary outcomes:
measure: What factors have significant odds ratios in a logistic model of the risk of one year mortality?
timeFrame: One year
measure: Is cohort an independent risk factor in a logistic model of one year mortality?
timeFrame: One year
Secondary outcomes:
measure: Does acute disease severity, hospital length of stay or ICU length of stay affect the significance of variables when added to the risk model in Outcome 1 for the ICU cohort?
timeFrame: One year
Other outcomes:
Locations:
city: Uppsala
country: Sweden
facility: Uppsala University
Study officials:
affiliation: Uppsala University
name: Miklos Lipcsey, Professor
role: PRINCIPAL_INVESTIGATOR
References: