louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT03221153: Patient Safety Skills for Medical Students
Official title: Simulation for the Evaluation of General Skills in Patient Safety and Quality in Undergraduate Medical Students
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Knowledge, Attitudes, Practice
Keywords: Patient Safety
Quality
Simulation
Undergraduate
Medical Student
Lead sponsor: Instituto Tecnologico y de Estudios Superiores de Monterey
Sponsor class: OTHER
First posted: 2017-07-18
Enrollment: 140
Sex: ALL
Minimum age (years): 21
Maximum age (years): 24
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Intervention model description: Randomized controlled trial of two educational interventions
Primary purpose: OTHER

Brief summary: In this project, the authors aim to evaluate the use of high fidelity simulation as a method of evaluation of general skills in fifth year medical students about patient quality and safety in a hospital setting.

Detailed description: Undergraduate training in patient safety and healthcare quality is often overlooked by medical curricula.

Simulation techniques have been used in different subjects as a support for learning invasive techniques in surgical areas, but it has not been used to improve knowledge and performance on patient quality domains that would be applied in real life scenarios.

This project is a randomized trial for medical students undertaking the course in "Quality and Patient Safety". The authors will randomized students at the beginning of each rotation into two groups: a) an intervention group (where students will take the simulation and will be evaluated by a final written exam); and b) a control group (where students will take only the usual teaching in classrooms and will be evaluated with the same written exam). Furthermore, students will be asked to fill a questionnaire to obtain their attitudes and knowledge about the topics in quality and safety in healthcare.

Eligibility criteria: Inclusion Criteria:

* 5th year medical students enrolled in the course "Quality and Patient Safety" in the Tecnológico de Monterrey School of Medicine, Campus Monterrey.

Primary outcomes:
measure: Mean score of skills and knowledge about quality and patient safety
timeFrame: One year
Secondary outcomes:
measure: Qualitative Evaluation of Attitudes and preferences towards patient safety
timeFrame: One year
Other outcomes:
Locations:
city: Monterrey
country: Mexico
facility: Tecnologico de Monterrey School of Medicine
state: Nuevo Leon
Study officials:
affiliation: Instituto Tecnologico y de Estudios Superiores de Monterey
name: Karla Pacheco, MD
role: PRINCIPAL_INVESTIGATOR
References:
citation: Miller GE. The assessment of clinical skills/competence/performance. Acad Med. 1990 Sep;65(9 Suppl):S63-7. doi: 10.1097/00001888-199009000-00045. No abstract available.
citation: Sperling JD, Clark S, Kang Y. Teaching medical students a clinical approach to altered mental status: simulation enhances traditional curriculum. Med Educ Online. 2013 Apr 3;18:1-8. doi: 10.3402/meo.v18i0.19775.
Clinical trial NCT02589353: Human Oral Detection of Glucose Olygomers
Official title: The Role of Salivary Contents in Taste Perception of Starch and Its Hydrolysis Products
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE4
Conditions: Healthy Volunteers
Lead sponsor: Oregon State University
Sponsor class: OTHER
First posted: 2015-10-28
Enrollment: 157
Sex: ALL
Minimum age (years): 18
Maximum age (years): 60
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: BASIC_SCIENCE

Brief summary: Although salivary contents play a major role in the early stage of food digestion process, their role in taste perception of glucose polymers is essentially unknown. It is hypothesized that the differences in salivary contents, more specifically salivary amylase concentration and activity, influence taste perception of glucose polymers and ultimately eating behavior, which is related to risks in various diseases. The current project will investigate the variation in salivary contents across individuals and its role in taste perception of glucose polymers.


Eligibility criteria: Inclusion Criteria:

* self-reported healthy adults between the ages of 18-60 who are fluent in English.

Exclusion Criteria:

* adults 61 years old and above
* smokers
* pregnant women
* taking any prescription pain/ insulin medication
* has a history of taste or smell loss or other oral disorders (e.g., burning mouth syndrome)
* has current oral lesions, canker sores, or piercings
* has a history of food allergy

Primary outcomes:
measure: Detection of glucose polymers in the presence of acarbose
timeFrame: up to 5 years
Secondary outcomes:
Other outcomes:
Locations:
city: Corvallis
country: United States
facility: Department of Food Science and Technology
state: Oregon
Study officials:
affiliation: Oregon State University
name: Juyun Lim
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT00914953: Oxytocin and Social Behavior Over the Lifespan
Official title: Oxytocin and Social Behavior Over the Lifespan: Interventional Study
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: EARLY_PHASE1
Conditions: Social Activity
Keywords: social isolation
cooperative behavior
depression
loneliness
happiness
empathy
Lead sponsor: Claremont Graduate University
Sponsor class: OTHER
First posted: 2009-06-05
Enrollment: 41
Sex: ALL
Minimum age (years): 50
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: SINGLE_GROUP
Primary purpose: BASIC_SCIENCE

Brief summary: This study will investigate if intranasal oxytocin (a hormone naturally produced in the body) promotes motivation for, and engagement in, social activities in older adults.

Detailed description: Using a double-blind and placebo controlled design, this study seeks to determine if a short course of exogenous oxytocin (OT) will induce changes in social activities in residentially housed older adults (OAs) during a 10-day treatment period, and after it ends. Because OT is associated with peri-reproductive behaviors, OT release in OAs is expected to be attenuated relative to younger adults. If OT release is low in OAs as we hypothesize, augmenting OT may increase their desire for social interactions, increase the frequency of participation in social activities and augment the number of and quality of social ties, thereby providing protection against disease, early death, cognitive decline, and depression. Research in rodents suggests that social interactions themselves may change chronic OT levels (Carter \& Keverne, 2002; Carter \& Altemus, 1997), in a positive feedback loop. In order to demonstrate OT as the causal mechanism, we propose to infuse oxytocin and then track the desire for, quantity of, and quality of social activities.

Eligibility criteria: Inclusion Criteria:

* residentially housed
* English fluency

Exclusion Criteria:

* non ambulatory
* severe psychiatric problems presently or in the recent past
* severe medical problems (e.g., cancer, diabetes, advanced heart disease)
* irregular heart beat
* treatment using psychoactive medications (other than antiepileptics, mood stabilizers, or Ambien)
* inability to adequately communicate with the research team
* treatment with an experimental drug
* excessive fatigue suggesting hypothyroidism

Primary outcomes:
measure: confirm increased social activities in treatment condition compared to control condition via self-report.
timeFrame: 30 days
Secondary outcomes:
measure: Evidence of greater psychological health for treatment condition as compared to control condition.
timeFrame: 30 days
Other outcomes:
Locations:
city: Loma Linda
country: United States
facility: Linda Valley Villa
state: California
Study officials:
References:
Clinical trial NCT00671177: Clinical Evaluation of Water Immersion Colonoscopy Insertion Technique
Official title: Clinical Evaluation of Water Immersion Colonoscopy Insertion Technique
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Colonoscopy
Digestive System
Endoscopy
Gastrointestinal Disease
Keywords: colonoscopy
diagnostic techniques
digestive system
endoscopy
gastrointestinal
Lead sponsor: VA Palo Alto Health Care System
Sponsor class: FED
First posted: 2008-05-05
Enrollment: 229
Sex: MALE
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: DIAGNOSTIC

Brief summary: Recent studies indicate that infusing 300 milliliters of water (in lieu of air) into the rectum and left colon through the colonoscope as it is being inserted during a colonoscopy examination can allow easier endoscope advancement. This method may prevent stretching of the colon, and ultimately reduce pain induced during colonoscopy. Improvements in patient comfort and cooperation, may increase the efficiency and success rate of complete colonoscopy. The purpose of the study is to test the efficacy of the water immersion technique in patients colonoscopy.


Eligibility criteria: Inclusion Criteria:

* presentation for colonoscopy
* male
* age 18 or older

Exclusion Criteria:

* women
* known inflammatory bowel disease
* presentation for emergency colonoscopy
* history of partial colectomy
* chronic narcotic or benzodiazepine use

Primary outcomes:
measure: Colonoscopy Success With Minimal Sedation
timeFrame: At the time of the procedure
Secondary outcomes:
measure: Time to Cecum
timeFrame: At the time of the procedure
measure: Patient Satisfaction
timeFrame: At the time of the procedure
Other outcomes:
Locations:
city: Palo Alto
country: United States
facility: VA Palo Alto Health Care System
state: California
Study officials:
affiliation: VA Palo Alto/Stanford University Medical Center
name: Roy Soetikno, MD, MS
role: PRINCIPAL_INVESTIGATOR
References:
citation: Leung CW, Kaltenbach T, Soetikno R, Wu KK, Leung FW, Friedland S. Water immersion versus standard colonoscopy insertion technique: randomized trial shows promise for minimal sedation. Endoscopy. 2010 Jul;42(7):557-63. doi: 10.1055/s-0029-1244231. Epub 2010 Jun 30.
Clinical trial NCT01113177: Effect of Functional Treatment on Mandibular Asymmetric Growth
Official title: Effect of Functional Treatment on Mandibular Asymmetry Caused by Unilateral Temporomandibular Joint Involvement in Children With Juvenile Idiopathic Arthritis
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Temporomandibular Joint Disorder
Keywords: Mandibular growth temporomandibular arthritis
Lead sponsor: University of Aarhus
Sponsor class: OTHER
Collaborators: name: Aarhus University Hospital
First posted: 2010-04-29
Enrollment: 22
Sex: ALL
Minimum age (years): 5
Maximum age (years): 18
Standard ages: CHILD
ADULT
Accepts healthy volunteers: no
Observational model: CASE_ONLY
Time perspective: RETROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Juvenile Idiopathic arthritis patients diagnosed with unilateral temporomandibular joint arthritis and an asymmetric mandibular growth pattern

Brief summary: Temporomandibular joint (TMJ) arthritis is known to alter the mandibular development in children diagnosed with juvenile idiopathic arthritis. In a number of cases a genuine breakdown of cartilage and bone is seen in the affected joint which leads to asymmetric mandibular growth in the affected side. In cases of unilateral TMJ involvements severe mandibular asymmetric mandibular growth deviations are seen. We hypothesize that these growth deviations can be minimized and controlled by the use functional orthodontic appliance therapy.

Detailed description: This is a retrospective study design with the aim to evaluate the clinical procedures we have used the last 15 years to treat JIA patients with unilateral TMJ arthritis. More specifically, the purpose is to evaluate the mandibular growth in all JIA patients with unilateral TMJ arthritis and an asymmetric mandibular growth pattern treated with non-surgical distraction splint therapy between 1994 and 2010 at the dep. of Orthodontics, Aarhus University, Denmark. The evaluation is based on radiological examinations at the beginning of their non-surgical distraction treatment as well as after the patients have finished their distraction-splint therapy.

Eligibility criteria: Inclusion Criteria:

* Juvenile Idiopathic arthritis patients diagnosed with unilateral temporomandibular joint arthritis and an asymmetric mandibular growth pattern

Exclusion Criteria:

* Juvenile Idiopathic arthritis patients diagnosed with bilateral temporomandibular joint arthritis
* Juvenile Idiopathic arthritis patients with no mandibular growth potential left.

Primary outcomes:
measure: Mandibular growth in children with unilateral TMJ arthritis treated with an acrylic distraction splint
timeFrame: average treatment with splint is 6.4 years
Secondary outcomes:
Other outcomes:
Locations:
city: Aarhus
country: Denmark
facility: Dep. of Orthodontics, Aarhus University
Study officials:
name: Thomas K Pedersen, DDS Ph.D
role: STUDY_DIRECTOR
References:
Clinical trial NCT05815277: Awareness of Parents About Management of Dental Avulsion
Official title: Awareness of Emergency Management of Permanent Teeth Avulsion in Children Among a Group of Egyptian Parents: a Cross Sectional Study.
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Dental Trauma
Lead sponsor: Cairo University
Sponsor class: OTHER
First posted: 2023-04-18
Enrollment: 330
Sex: ALL
Minimum age (years): 6
Maximum age (years): 12
Standard ages: CHILD
Accepts healthy volunteers: yes
Observational model: OTHER
Time perspective: CROSS_SECTIONAL
Sampling method: PROBABILITY_SAMPLE
Study population: the patients going to diagnostic clinic of pediatric dentistry and dental public health department, Cairo university

Brief summary: Aim of the study:

assessment of level of awareness of parents about emergency management of permanent teeth avulsion in children

Detailed description: our study asses level by awareness of parents about emergency management of dental avulsion through questionnaire , the study will be done in diagnosis clinic of faculty of oral and dental medicine Cairo university

Eligibility criteria: Inclusion Criteria:

* parents who have children aged from 6 to 12 years

Exclusion Criteria:

* parents who refused to participate in questionnaire
* parents who have children above or below this age

Primary outcomes:
measure: level of awareness of parents about emergency management of avulsed permanent teeth
timeFrame: 2 months
Secondary outcomes:
Other outcomes:
Locations:
city: Cairo
country: Egypt
facility: Faculty of Oral and Dental Medicine Cairo University
Study officials:
References:
Clinical trial NCT01295177: Topic Insulin Accelerates Wound Healing in Diabetes
Official title: Topic Insulin Accelerates Wound in Diabetes
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE1
PHASE2
Conditions: Diabetes Mellitus
Wounds
Keywords: wound healing
diabetes mellitus
Lead sponsor: University of Campinas, Brazil
Sponsor class: OTHER
Collaborators: name: Fundação de Amparo à Pesquisa do Estado de São Paulo
First posted: 2011-02-14
Enrollment: 22
Sex: ALL
Minimum age (years): 18
Maximum age (years): 80
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The purpose of this study is to determine whether topic insulin is effective to accelerates wound healing in diabetes patients

Detailed description: Wound healing is impaired in diabetes mellitus, but the mechanisms involved are not well established. The purpose of this study was to investigate the effect of a topic insulin cream on wound healing in diabetic patients. age eligible for study:18 years old-older gender eligible for study:both accepts healthy volunteers:no have a proband with T1DM or T2DM. A proband is an individual with more than one year of diagnosis.

have proband with a wound that is difficult to be healed for at least three months.

patients with serum creatinine \<1.5mg/dl Does not satisfy the above inclusion criteria infection diagnosed wound patients with cellulitis, venous stasis, inadequate perfusion, osteomyelitis and patient's inability to attend clinics for follow up

Eligibility criteria: Inclusion Criteria:

age eligible for study:18 years old-older gender eligible for study:both accepts healthy volunteers:no have a proband with T1DM or T2DM. A proband is an individual with more than one year of diagnosis. have proband with a wound that is difficult to be healed for at least three months.

patients with serum creatinine \<1.5mg/dl

Exclusion Criteria:

Does not satisfy the above inclusion criteria infection diagnosed wound patients with cellulitis, venous stasis, inadequate perfusion, osteomyelitis and patient's inability to attend clinics for follow up

Primary outcomes:
measure: % of Wound healing closing measured each week
timeFrame: 7 days
Secondary outcomes:
measure: Complete wound healing
timeFrame: 8 weeks
Other outcomes:
Locations:
Study officials:
affiliation: University of Campinas (UNICAMP)
name: Maria Helena M Lima, PhD
role: STUDY_CHAIR
affiliation: University of Campinas (UNICAMP)
name: Mario J Saad, MD PhD
role: PRINCIPAL_INVESTIGATOR
References:
citation: Lima MH, Caricilli AM, de Abreu LL, Araujo EP, Pelegrinelli FF, Thirone AC, Tsukumo DM, Pessoa AF, dos Santos MF, de Moraes MA, Carvalheira JB, Velloso LA, Saad MJ. Topical insulin accelerates wound healing in diabetes by enhancing the AKT and ERK pathways: a double-blind placebo-controlled clinical trial. PLoS One. 2012;7(5):e36974. doi: 10.1371/journal.pone.0036974. Epub 2012 May 25.
Clinical trial NCT04538677: Video Consultation During Follow up Surgical Care
Official title: Video Consultation During Follow up Care: Effect on Quality of Care and Patient- and Provider Attitude in Patients With Colorectal Cancer
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Colorectal Cancer
Keywords: Video Consultation
Virtual visits
Lead sponsor: Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Sponsor class: OTHER
First posted: 2020-09-04
Enrollment: 50
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: Patients with colorectal cancer scheduled for appointment at the surgical oncology outpatient a tertiary referral center.

Brief summary: The aim of this study was to compare the willingness to use and attitude towards VC amongst both patients with colorectal cancer and healthcare providers during follow up care. Second, to determine the satisfaction with the quality of the healthcare provider and the usability of the used VC technology. 50 patients will be asked to choose between video consultation or face-to-face contact at the outpatient surgical clinic.


Eligibility criteria: Inclusion Criteria:

* Age 18 years or older
* Fluent in speaking and writing in Dutch
* Follow up appointments in which overall progress, new complaints, results with good news and treatment was discussed were considered feasible.

Exclusion Criteria:

* Introductory appointments
* Bad news consultations
* Physical examination needed
* No access to Internet
* No access to a smartphone, tablet or computer with a camera
* Not willing to activate their electronic patient portal

Primary outcomes:
measure: Attitude and satisfaction with video consultation
timeFrame: Immediately after the consult
Secondary outcomes:
measure: Usability of the video consultation technology
timeFrame: Immediately after the test consult
measure: Quality of provided care by surgeon: MSF questionnaire
timeFrame: Immediately after the consult
measure: Satisfaction of surgeons: Questionnaire
timeFrame: Immediately after the consult
Other outcomes:
Locations:
city: Amsterdam
country: Netherlands
facility: Amsterdam UMC, location AMC
Study officials:
References:
Clinical trial NCT06907277: Dexmedetomidine Enhancing the Recovery After Cardiac Surgery
Official title: Dexmedetomidine-based Enhanced Recovery After Cardiac Surgery Improves Outcome Regarding Analgesia, Sleep Disorders, and Postoperative Delirium
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Post-cardiac Surgery
Lead sponsor: Benha University
Sponsor class: OTHER
First posted: 2025-04-02
Enrollment: 75
Sex: ALL
Minimum age (years): 40
Maximum age (years): 65
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: Enhanced Recovery After Surgery (ERAS) aims to facilitate a quicker and smoother recovery period following surgical procedures. The implementation of these protocols may lead to patients returning to their daily activities sooner, experiencing greater satisfaction with their care, and potentially encountering fewer complications, ultimately contributing to shorter hospital stays. However, a common challenge in the postoperative phase is postoperative delirium(POD). This complication can lead to both immediate and long-term cognitive impairments, negatively impact overall health outcomes, and increase the financial burden on the healthcare system. Interestingly, dexmedetomidine, known as DXM, is a medication that selectively targets certain receptors in the brain and offers sedative properties with minimal impact on breathing. This characteristic is noteworthy because it may help regulate sleep patterns and support the preservation of cognitive function during the recovery period.


Eligibility criteria: Inclusion Criteria:

* Patients of American Society of Anesthesiologists Classification (ASA) grade II-III;
* Patients who were planned to have Coronary Artery Bypass Graft (CABG);
* Patients were free of exclusion criteria.

Exclusion Criteria:

* Patients with preoperative high risk for getting Post Operative Delirium or sleep disorders,
* Patients with American Society of Anesthesiologists Classification (ASA) grade\>III;
* Patients with heart failure, left ventricle ejection fraction of \<25%,
* Patients with uncontrolled diabetes mellitus, coagulopathy, or history of uncompensated renal or hepatic diseases

Primary outcomes:
measure: Significant Enhancement of Post Operative Recovery Levels After Dexmedetomidine Administration in Cardiac Surgery.
timeFrame: 3 months
Secondary outcomes:
Other outcomes:
Locations:
city: Banhā
country: Egypt
facility: Benha University
state: El Qalyoubia
Study officials:
References: