louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT03222934: A Multislice Computed Tomographic Study of the Sphenoid Sinus
Official title: A Multislice Computed Tomographic Study of the Sphenoid Sinus
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Nasal Disorder
Lead sponsor: Assiut University
Sponsor class: OTHER
First posted: 2017-07-19
Enrollment: 90
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: OTHER
Time perspective: CROSS_SECTIONAL
Sampling method: PROBABILITY_SAMPLE
Study population: patients with nasal disorders with free sphenoid sinus

Brief summary: •Sphenoid sinus is located in the body of sphenoid bone, closed with a thin plate of bone tissue that separates it from the surrounding important structures .Detailed, meticulous preoperative radiological study of sphenoid sinus is the key to successful and safe functional endoscopic sinus surgery and transsphenoidal surgery. The purpose of the study is to delineate the sphenoid sinus radiologically using the multislice computed tomography and to decrease morbidity and mortality during skull base surgeries as the sphenoid sinus is one of the most variable of all sinuses and its relation to vital vascular and nervous elements make its approach a challenge for endoscopic surgeons

Detailed description: Sphenoid sinus is located in the body of sphenoid bone, closed with a thin plate of bone tissue that separates it from the surrounding important structures such as the optic nerve, optic chiasm, cavernous sinus, pituitary gland, and internal carotid artery. Detailed, meticulous preoperative radiological study of sphenoid sinus variations as in Onodi cells (Sphenoethmoidal air cell) is an anatomical variant of the paranasal sinuses, important due to its close proximity to the optic nerve and internal carotid artery. , Pnumatization pattern as the extent of pneumatization is highly variable and potentially jeopardizing to surrounding vital structures , Septation pattern , Intercarotid distance (in millimeters), Bony covering of carotid artery, Bony covering of optic nerve.is the key to successful and safe functional endoscopic sinus surgery and transsphenoidal surgery. The purpose of the study is to delineate the sphenoid sinus radiologically using the multislice computed tomography and to decrease morbidity and mortality during skull base surgeries as the sphenoid sinus is one of the most variable of all sinuses and its relation to vital vascular and nervous elements make its approach a challenge for endoscopic surgeons

Eligibility criteria: Inclusion Criteria:

* patients with free sphenoid sinus

Exclusion Criteria:

* pathology in the sphenoid sinus
* refusal of patients for inclusion in the study

Primary outcomes:
measure: The rate of anatomical variations of the sphenoid sinus
timeFrame: 30 minutes
Secondary outcomes:
Other outcomes:
Locations:
city: Assiut
country: Egypt
facility: Assiut University
Study officials:
References:
Clinical trial NCT03480334: Abscopal Effect of Radiotherapy and Nivolumab in Relapsed Hodgkin Lymphoma After Anti-PD1 Therapy
Official title: Abscopal Effect of Radiotherapy and Nivolumab in Relapsed Hodgkin Lymphoma After Anti-PD1 Therapy
Study type: INTERVENTIONAL
Overall status: ACTIVE_NOT_RECRUITING
Phase: PHASE2
Conditions: Classical Hodgkin Lymphoma
Lead sponsor: University of Cologne
Sponsor class: OTHER
First posted: 2018-03-29
Enrollment: 26
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: TREATMENT

Brief summary: The aim of the trial is to improve efficacy of nivolumab in patients with relapsed or refractory HL who recently progressed on anti-PD1 therapy. Nivolumab is highly effective and well tolerated in rrHL, nevertheless CR-rates are low and a considerable proportion of patients suffers from progressive disease. Localized RT induces an immunogenic effect which might work synergistically and facilitate augmented systemic (i.e. abscopal) responses in combination with nivolumab.


Eligibility criteria: Inclusion Criteria:

* Progression of refractory or relapsed cHL during treatment with an anti-PD1 agent
* At least two distinct FDG-avid HL-lesions with at least 5 cm distance between them, and one of them considered eligible for irradiation with 20Gy based on localization and prior RT exposure
* Age at registration ≥ 18 years

Exclusion Criteria:

* Nodular-lymphocyte predominant HL (NLPHL) or composite/greyzone lymphoma
* Lymphoma involving the central nervous system
* Naïve to treatment with anti-PD1 targeting antibodies

Primary outcomes:
measure: Abscopal response rate (ARR-6)
timeFrame: 12 weeks
Secondary outcomes:
Other outcomes:
Locations:
city: Cologne
country: Germany
facility: 1st Department of Medicine, Cologne University Hospital
Study officials:
affiliation: University of Cologne, I. Dept. of Medicine
name: Andreas Engert, Prof.
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT03817034: Multimodal Analgesia for the Reduction of Postoperative Opioid Consumption
Official title: Multimodal Analgesia for the Reduction of Postoperative Opioid Consumption
Study type: INTERVENTIONAL
Overall status: WITHDRAWN
Phase: EARLY_PHASE1
Conditions: Pain
Keywords: multimodal
dexmedetomidine
ropivacaine
ketorolac
pain management
opioid sparing
analgesia
Lead sponsor: Massachusetts General Hospital
Sponsor class: OTHER
First posted: 2019-01-25
Enrollment: 0
Sex: ALL
Minimum age (years): 18
Maximum age (years): 99
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: TREATMENT

Brief summary: The investigators are performing this research study to investigate the efficacy of local infiltration of the surgical wound combining dexmedetomidine, ropivacaine, and ketorolac (treatment group) versus the current standard of care (historical control group), for post-operative pain management.

Detailed description: During this research study, patients recommended for a rectus sheath block during surgery will receive a novel combination of non-opioid drugs. Data from the treatment group will be compared to surgical outcomes of a historically matched control group to investigate the ability of this drug combination to reduce post-operative pain and post-operative opioid consumption.

Eligibility criteria: Inclusion Criteria:

* Age greater than 18 years
* American Society of Anesthesiologist Physical Status Classification 1-3
* Undergoing surgery requiring a rectus sheath block

Exclusion Criteria:

* American Society of Anesthesiologist Physical Status Classification of 4 or beyond
* history of opiate of illicit substance abuse, chronic pain, or neurological dysfunction

Primary outcomes:
measure: Change in post-operative opioid consumption
timeFrame: 48 hours
measure: Change in post-operative pain scores
timeFrame: 48 hours
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
affiliation: Massachusetts General Hospital
name: Emery N Brown, M.D., Ph.D.
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT05039034: Screening and Management of High-risk Populations of Stroke in Dehui City
Official title: Screening and Management of High-risk Populations of Stroke in Dehui City
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Cerebrovascular Accident
Stroke
Hypertension
Diabetes Mellitus
Dyslipidemias
Keywords: Stroke/epidemiology
Stroke/prevention and control
Risk Factors
Cognition
Surveys and Questionnaires
Lead sponsor: The First Hospital of Jilin University
Sponsor class: OTHER
Collaborators: name: Dehui People's Hospital
First posted: 2021-09-09
Enrollment: 4100
Sex: ALL
Minimum age (years): 40
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: OTHER
Time perspective: CROSS_SECTIONAL
Sampling method: PROBABILITY_SAMPLE
Study population: Target population aged 40 years and over (born before December 31,1975) was selected from Dehui City by means of group sampling.

Brief summary: This epidemiological survey is to analyze the prevalence rate of stroke and exposure rate of risk factors in sampling population aged 40 years and over (born before December 31,1975) in Dehui City, to provide scientific basis for pertinent prevention and control of stroke in Jilin Province, and to provide valuable data for the high-risk groups to carry out regular follow-up and standardized management.


Eligibility criteria: Inclusion Criteria:

* Aged 40 years and over in Dehui City
* Willing to participate in the study and follow-up visits
* Signed an informed consent

Exclusion Criteria:

* Life expectancy\<3 years
* Unwilling to participate in the study and follow-up visits
* Living away from Dehui City over 6 months
* Unable to cooperate with examination and questionnaire due to mental disease

Primary outcomes:
measure: Prevalence rate of stroke
timeFrame: 4 months
measure: Prevalence rate of hypertension
timeFrame: 4 months
measure: Prevalence rate of diabetes mellitus
timeFrame: 4 months
measure: Prevalence rate of dyslipidemia
timeFrame: 4 months
Secondary outcomes:
Other outcomes:
Locations:
city: Changchun
country: China
facility: First Hospital of Jilin University
state: Jilin
Study officials:
affiliation: The First Hospital of Jilin University
name: Yi Yang, M.D. Ph.D.
role: STUDY_CHAIR
affiliation: The First Hospital of Jilin University
name: Ying-Qi Xing, M.D. Ph.D.
role: STUDY_DIRECTOR
affiliation: The First Hospital of Jilin University
name: Zhen-Ni Guo, M.D.
role: STUDY_DIRECTOR
affiliation: The First Hospital of Jilin University
name: Fu-Liang Zhang, M.D.
role: PRINCIPAL_INVESTIGATOR
affiliation: The First Hospital of Jilin University
name: Hao-Yuan Liu, M.D.
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT00156234: Skeletal Muscle Dysfunction in Heart Failure
Official title: Training and Congestive Heart Failure
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Heart Failure, Congestive
Lead sponsor: Ullevaal University Hospital
Sponsor class: OTHER
Collaborators: name: Norwegian Health Association
name: Norwegian School of Sport Sciences
name: The Research Council of Norway
name: University of Oslo
First posted: 2005-09-12
Enrollment: 45
Sex: ALL
Minimum age (years): 40
Maximum age (years): 78
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: ECT

Brief summary: Patients suffering from congestive heart failure report reduced exercise capacity. This skeletal muscle dysfunction is also detectable when using small muscle groups which should not put any demand on the heart.

We hypothesize that congestive heart failure has systemic effects that causes the skeletal muscle dysfunction.


Eligibility criteria: Inclusion Criteria:

* Coronary Heart Failure
* Ejection fraction \<35%
* NYHA 2-3
* Spirometry FEV1 \> 80%

Exclusion Criteria:

* Cardiomyopathy
* Transplantation candidate
* Active malignancy
* Restraining skeletal-muscular disease
* Claudication in legs
* Hospitalized last 30 days due to acute ischemic episode
* Intravenous inotrope or vasodilatating drugs last 14 days prior to inclusion
* AMI last 8 weeks prior to inclusion
* Organized training last 4 months
* Smoking on daily basis last 4 months
* Creatinin \< 150microliters/liter

Primary outcomes:
Secondary outcomes:
Other outcomes:
Locations:
city: Oslo
country: Norway
facility: Institute for Experimental Medical Research
city: Oslo
country: Norway
facility: Norwegian School of Sport Sciences
Study officials:
affiliation: Institute for Experimental Medical Research, Ullevaal University Hospital
name: Ole M Sejersted, Professor
role: STUDY_CHAIR
affiliation: Institute for Experimental Medical Research, Ullevaal University Hospital
name: Per Kristian B Lunde, Post Doc
role: STUDY_DIRECTOR
affiliation: Institute for Experimental Medical Research, Ullevaal University Hospital
name: Ivar Sjaastad, Post Doc
role: STUDY_DIRECTOR
affiliation: Norwegian School of Sport Sciences
name: Jostein Hallen, Professor
role: STUDY_CHAIR
affiliation: Institute for Experimental Medical Research, Ullevaal University Hospital
name: Morten Munkvik, Ph.D student
role: PRINCIPAL_INVESTIGATOR
affiliation: Institute for Experimental Medical Research, Ullevaal University Hospital
name: Tommy A Rehn, Vit.ass.
role: PRINCIPAL_INVESTIGATOR
affiliation: Norwegian School of Sport Sciences
name: Gunnar S Petersen, Ph.D student
role: PRINCIPAL_INVESTIGATOR
References:
citation: Munkvik M, Rehn TA, Slettalokken G, Hasic A, Hallen J, Sjaastad I, Sejersted OM, Lunde PK. Training effects on skeletal muscle calcium handling in human chronic heart failure. Med Sci Sports Exerc. 2010 May;42(5):847-55. doi: 10.1249/MSS.0b013e3181c29ec1.
Clinical trial NCT00261534: Cancer Related Fatigue in Patients Receiving Chemotherapy
Official title: Outcomes Research on the Course of Cancer Related Fatigue Throughout Five Chemotherapy Treatments
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Cancer
Fatigue
Keywords: Chemotherapy
Lead sponsor: Medical Center Alkmaar
Sponsor class: OTHER
First posted: 2005-12-05
Enrollment: 90
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: DEFINED_POPULATION
Time perspective: PROSPECTIVE

Brief summary: The purpose of this study is to examine the degree of fatigue in patients receiving chemotherapy. Special interest goes out to the course of fatigue throughout five treatments and the actions taken by patients to reduce this fatigue.The correlation between fatigue and haemoglobin will also be subject of study.


Eligibility criteria: Inclusion Criteria:

* Diagnosis of cancer requiring chemotherapy treatment

Exclusion Criteria:

* Pregnancy
* Psychological illness
* Life expectancy less than three months
* Lack of basic proficiency in Dutch

Primary outcomes:
Secondary outcomes:
Other outcomes:
Locations:
city: Alkmaar
country: Netherlands
facility: Medical Centre Alkmaar
state: Noord-Holland
Study officials:
affiliation: Medical Centre Alkmaar, Hospital Pharmacy
name: D. Hilarius, MSc
role: STUDY_DIRECTOR
References:
Clinical trial NCT05486234: CARS: Cannabis and Alcohol Reduction Study
Official title: Brief Computerized Intervention for Reducing Adolescent Cannabis and Alcohol Use
Study type: INTERVENTIONAL
Overall status: RECRUITING
Phase: NA
Conditions: Cannabis Use
Alcohol Use, Unspecified
Substance Use
Substance Use Disorders
Lead sponsor: Medical University of South Carolina
Sponsor class: OTHER
Collaborators: name: National Institute on Drug Abuse (NIDA)
First posted: 2022-08-03
Enrollment: 52
Sex: ALL
Minimum age (years): 13
Maximum age (years): 17
Standard ages: CHILD
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The study will test a computerized treatment with subjects ages 13-17 years who are seeking treatment for alcohol and/or cannabis use. Follow-up assessments will be conducted at one- and three-months following treatment.


Eligibility criteria: Inclusion Criteria:

* between the ages of 13 and 17
* be seeking treatment for either cannabis or alcohol use;
* report co-occurring alcohol and cannabis use during the past three months (i.e., participants who report using both alcohol and cannabis during the three months prior to participation in the study, regardless of if the use was simultaneous)
* have a caregiver willing to participate and provide consent.

Primary outcomes:
measure: Change in cannabis use as assessed by Timeline Followback
timeFrame: Baseline and Three-Month Follow-up
measure: Change in alcohol use as assessed by Timeline Followback
timeFrame: Baseline and Three-Month Follow-up
measure: Change in Cannabis Approach Bias (D-Score)
timeFrame: Baseline, One-Week Follow-up, and Three-Month Follow-up
measure: Change Cannabis Approach Bias (D-Score)
timeFrame: Baseline, One-Week Follow-up, and Three-Month Follow-up
Secondary outcomes:
Other outcomes:
Locations:
city: Charleston
country: United States
facility: Medical University of South Carolina
state: South Carolina
Study officials:
References:
Clinical trial NCT03248934: Patient Performed Examination for Patients With Intra-articular Hip Pain
Official title: Delineating the Concurrent Validity and Diagnostic Accuracy of a Patient Performed Examination for Patients With Intra-Articular Hip Pain: A Proof of Concept Study
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Hip Pain Chronic
Hip Disease
Lead sponsor: Duke University
Sponsor class: OTHER
First posted: 2017-08-15
Enrollment: 80
Sex: ALL
Minimum age (years): 18
Maximum age (years): 80
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NON_RANDOMIZED
Intervention model: PARALLEL
Primary purpose: OTHER

Brief summary: The primary objective of this study is evaluate the diagnostic accuracy of a patient self-administered clinical examination of the hip compared with a traditional clinical examination (i.e. index test).


Eligibility criteria: Inclusion Criteria:

* Age: 18-80 years
* Seeking care for hip related pain and/or clicking, catching, giving way or stiffness
* Able to sign or verbalize study consent
* No other medical conditions (e.g. gynecological or urinary pathology) that may affect study results
* English speaking

Exclusion Criteria:

* Patients with primary lumbar spine, sacro-iliac or other non-hip related pain as determined with clinical examination
* Previous hip surgery
* Previous hip injury that would normally exclude from examination as standard practice
* Unable to sign or verbalize consent
* Other non-musculoskeletal pathology that may affect study results (e.g. gynecological or urinary pathology)
* Non-English speaking

Primary outcomes:
measure: Sensitivity
timeFrame: End of clinician examination, 20 minutes
Secondary outcomes:
measure: Specificity
timeFrame: End of clinician examination, 20 minutes
measure: Diagnostic accuracy measure of positive likelihood ratio
timeFrame: End of clinician examination, 20 minutes
measure: Diagnostic accuracy measure of negative likelihood ratio
timeFrame: End of clinician examination, 20 minutes
measure: Diagnostic accuracy measure of post-test probabilities
timeFrame: End of clinician examination, 20 minutes
Other outcomes:
Locations:
city: Durham
country: United States
facility: Duke University Health System
state: North Carolina
Study officials:
affiliation: Duke University
name: Richard C. Mather
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT05278234: STEPS: An Efficacy Trial of a Chronic Pain Self-Management Program for Older Adults
Official title: An Efficacy Trial of Community Health Worker-Delivered Chronic Pain Self-Management Support for Vulnerable Older Adults
Study type: INTERVENTIONAL
Overall status: ACTIVE_NOT_RECRUITING
Phase: NA
Conditions: Chronic Pain
Lead sponsor: University of Michigan
Sponsor class: OTHER
Collaborators: name: National Institute on Aging (NIA)
name: Henry Ford Health System
First posted: 2022-03-14
Enrollment: 414
Sex: ALL
Minimum age (years): 50
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The goal of this study is to determine whether community health workers (CHWs)-i.e., lay health workers with close ties to the communities they serve - can effectively teach cognitive-behavioral pain management strategies to older adults in a disadvantaged urban setting. Specific aims are: to test, in a sample of 414 primarily African American older adults, whether the STEPS pain self-management intervention, delivered over 7 weeks through telephone sessions with a CHW and mobile health tools, improves pain outcomes at 2 and 12 months compared to a usual care control group. We will also assess the mechanisms by which the intervention may bring about positive changes in pain outcomes. We will use mixed quantitative and qualitative methods to assess participant engagement and satisfaction, and factors affecting implementation.


Eligibility criteria: Inclusion Criteria:

* Community-living
* Have a cell or landline phone
* Self-reported chronic musculoskeletal pain (pain in muscles or joints for \>= 3 months); \>=4 (0-10 scale) average pain level over last week; \>=1 day/previous 30 when pain made it difficult to do usual activities.
* Able to converse comfortably in English

Exclusion Criteria:

* Serious acute illness or hospitalization in last month
* Planned major surgery in next three months that would interfere with program participation (e.g., knee or hip replacement);
* Severe cognitive impairment or other severe physical or psychiatric disorder judged by study team to pose significant barrier to participation

Primary outcomes:
measure: Change in Pain Interference
timeFrame: Baseline, 2 months from baseline, and 12 months from baseline
Secondary outcomes:
measure: Participant Global Impression of Change--Pain
timeFrame: 2 months from baseline, and 12 months from baseline
measure: Participant Global Impression of Change - Functioning
timeFrame: 2 months from baseline, and 12 months from baseline
measure: Change in pain intensity
timeFrame: Baseline, 2 months from baseline, and 12 months from baseline
Other outcomes:
Locations:
city: Ann Arbor
country: United States
facility: University of Michigan
state: Michigan
Study officials:
References: