Clinical trial NCT04673734: Scan-rescan Reproducibility of Myelin Sensitive MRI Techniques
Official title: Scan-rescan Reproducibility of Myelin Sensitive MRI Techniques
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Myelin Integrity
Keywords: Magnetization Transfer Imaging (MTI)
Multi-echo Susceptibility-Based imaging (SBI)
Myelin Water Imaging (MWI)
T1 relaxometry (quantitative T1, qT1)
multi-shell diffusion
myelin sensitive MRI techniques
Lead sponsor: University Hospital, Basel, Switzerland
Sponsor class: OTHER
Collaborators: name: Hoffmann-La Roche
First posted: 2020-12-17
Enrollment: 13
Sex: ALL
Minimum age (years): 18
Maximum age (years): 80
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: healthy subjects recruited by public announcements (i.e. advertisement/flyer) on the University Hospital's and the University's notice board

Brief summary: This study is to assess the variation in the measurements of myelin sensitive MRI techniques in both white and grey matter in the brain.

Detailed description: Magnetization Transfer Imaging (MTI) permits the assessment of the integrity of macromolecules in brain tissue, such as myelin and cellular/axonal membrane components.

Multi-echo Susceptibility-Based imaging (SBI) provides quantitative susceptibility maps and T2\* maps that - when combined - permit the disentanglement of myelin from iron and various phases of myelin degradation.

Myelin Water Imaging (MWI) quantifies the water trapped between myelin layers by separating the multiple water components in T2 relaxometry data. In fact, the presence of myelin on water pools bound to it provokes a loss in magnetic resonance (MR)-signal coherence, which is more rapid than the one characterizing the water pools located within the axons or in the cytoplasm.

A method based on a spiral acquisition that achieves a myelin-specific signal in clinically compatible scan times is currently applied: T1 relaxometry (quantitative T1, qT1) - which measures the time that a perturbed nuclear spin distribution needs to get back to equilibrium in the longitudinal plane- is sensitive to a number of components of the brain tissue such as myelin, axonal diameter and the overall architectural organization of the brain tissue.

Finally, multi-shell diffusion allows the application of mathematical models of diffusion compartments, which in part are influenced by myelin integrity.

The goal of this study is to assess the stability of these techniques in scan-rescan experiment on 20 healthy subjects.

Eligibility criteria: Inclusion Criteria:

* No neurological or psychiatric disorder

Exclusion Criteria:

* Pregnancy
* Contraindication to MRI (eg, claustrophobia, metallic implants, pacemaker etc).
* Inability to give consent.

Primary outcomes:
measure: analysis of variance between MTI, SBI, MWI, T1 relaxometry and multi-shell diffusion obtained in each subject in each of the 3 scan sessions
timeFrame: 1 hour total scan time (during a time period of max. 1 week)
Secondary outcomes:
Other outcomes:
Locations:
city: Basel
country: Switzerland
facility: Neurologische Klinik und Poliklinik, University Hospital Basel
Study officials:
affiliation: Neurologische Klinik und Poliklinik, University Hospital Basel
name: Cristina Granziera, Prof. Dr. med.
role: PRINCIPAL_INVESTIGATOR
References: