Clinical trial NCT02574299: Characterization of Auditory Processing Involved in the Encoding of Speech Sounds
Official title: Characterization of Ascending and Descending Auditory Processing Involved in the Encoding of Speech Sounds in Adult and Children: Variability Related to Changes in Sensory Input or a Neurodevelopmental Disorder or Targeted Remediation
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Language Impairment
Hearing Loss
Keywords: dyslexia
training
auditory rehabilitation
hearing loss
evoked potentials
dichotic
plasticity
noise
Lead sponsor: Hospices Civils de Lyon
Sponsor class: OTHER
First posted: 2015-10-12
Enrollment: 25
Sex: ALL
Minimum age (years): 6
Maximum age (years): 70
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: NON_RANDOMIZED
Intervention model: PARALLEL
Primary purpose: BASIC_SCIENCE

Brief summary: The ability to encode the speech signal is determined by ascending and descending auditory processing. Difficulties in processing these speech signals are well described at the behavioral level in a specific language disorder. However, little is known about the underlying pathophysiological mechanisms. The assumption is that we should observe a degradation of the signal provided by the ear in the deaf subject while in case of specific language impairment it would be a phonemic disorder (possibly linked to a processing disorder auditory). The two population groups should therefore have different abnormalities of their central auditory process - which could be modified by the target remediation for each group.


Eligibility criteria: Inclusion Criteria:

For all subjects:

* native French speaker
* no medical treatment for behavior or neurological disorders
* normal or corrected vision
* right-handed
* normal otorhinolaryngology examination
* valid affiliation to social security
* no participation to another research study

For the normal-hearing subjects

* normal tonal hearing thresholds
* normal tympanometry

For the subjects without specific language impairment

* aged from 6 ro 40
* normal school attendance without scholastic retardation
* normal intellectual level
* normal for age reading skills
* no delayed speech (expression \& production)

For the children with specific language impairment

* aged fom 8 to 18
* persistent specific literacy difficulties with reading levels at least 18 months behind that of their peers
* normal intellectual level

For the hearing impaired subjects

* age from 18 to 70
* first auditory rehabilitation
* bilateral and symmetric hearing loss (±10 dB) with hearing thresholds between 0 and 25 dB at 0.25 kilohertz, 0 and 35 dB at 0.5 kilohertz, 0 and 50 dB at 1 kilohertz, 25 and 70 dB at 2 kilohertz, 25 and 80 dB at 3 kilohertz, 30 and 80 dB at 4 kilohertz

Exclusion Criteria:

* non signed assent
* treatment for depression, epilepsy, Parkinson's or alzheimer's disease during more than 6 months
* physical health deficiency
* mental retardation
* neurological or psychiatric disease incompatible with testing procedure

For children

* known problem of hearing loss or chronic middle ear disease whic compromized the hearing status
* schooling in a foreign language
* foreign language spoken at home with both parents

Primary outcomes:
measure: Change from Baseline speech auditory brainstem and late responses (composite and objective measure) in response to syllables (behavioral measure)
timeFrame: Arms 2 and 3: Baseline and 5 weeks / Arms 5 and 6: Baseline and 6 months / Arms 1 and 4: Baseline
Secondary outcomes:
measure: Change from Baseline medial olivocochlear system (MOCS) functioning measured using the contralateral suppressive effect of transient evoked otoacoustic emissions (composite measure)
timeFrame: Arms 2 and 3: Baseline and 5 weeks / Arms 5 and 6: Baseline and 6 months / Arms 1 and 4: Baseline
measure: Change from Baseline dichotic skills measured using central auditory processing tests (composite measure)
timeFrame: Arms 2 and 3: Baseline and 5 weeks / Arms 5 and 6: Baseline and 6 months / Arms 1 and 4: Baseline
measure: Change from Baseline speech-noise listening skills measured using logatomes tests (composite measure)
timeFrame: Arms 2 and 3: Baseline and 5 weeks / Arms 5 and 6: Baseline and 6 months / Arms 1 and 4: Baseline
Other outcomes:
Locations:
city: Lyon
country: France
facility: Sercive d'Audiologie et d'Exploration Orofaciales, Hôpital Edouard Herriot, Hospices Civils de Lyon
Study officials:
References: