Clinical trial NCT03376906: The Effects of High Intensity Interval Exercise in Obese
Official title: The Effects of High Intensity Interval Exercise With 1- and 3- Min Recovery Times in Obese
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Obesity
Endothelial Dysfunction
Keywords: Obesity
aerobic exercise
interval exercise
Lead sponsor: Federal University of Paraíba
Sponsor class: OTHER
First posted: 2017-12-19
Enrollment: 12
Sex: ALL
Minimum age (years): 18
Maximum age (years): 40
Standard ages: ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Intervention model description: The subjects were welcomed for a visit to the Laboratory of Studies of Physical Training Applied to Health, where they performed an evaluation of body composition, maximal ergospirometric exercise test, and three experimental sessions in a random order, which were performed with a 96 h interval between them. In order to obtain the experimental session order, the researcher asked each subject to pick out random numbers that were inside an opaque envelope generated at www.randomizer.org.

Before the experimental sessions, subjects were instructed to maintain a regular sleep pattern, and to not consume alcohol, caffeine or xanthines (coffee, chocolate, soft drinks and tea), take medication or exercise in the 24 h prior to the experimental protocol sessions. In addition, they were duly instructed to fill out the food registry (food recall).
Primary purpose: TREATMENT

Brief summary: Obesity is a complex and multifactorial disease. Excess weight is related to endothelial dysfunction, inflammation and oxidative stress which increases the risk for cardiovascular diseases. High-intensity interval exercise can release vasodilatory substances and promote increased muscle blood flow.

Detailed description: This study evaluated the effects of the recovery interval duration (1 vs. 3 min) in high intensity interval exercise (HIIE) on the hemodinamics responses in obese individuals. Twelve obese subjects (27 ± 3.8 yrs) were evaluated, who underwent three experimental sessions with a randomized crossover design: one control session (no exercise) and two HIIE sessions with the same workload (10 x 1min @92%VO2max / 1\[HIIE 1\] or 3\[HIIE 3\] min @0%). Forearm blood flow (FBF) and blood pressure (BP) were measured before and after the experimental sessions. Heart rate and relative perceived exertion were assessed during HIIE.

Eligibility criteria: Inclusion criteria for the study were obesity and the conditions of being insufficiently active, non-smokers and without previous history of: heart disease, obstructive or restrictive pulmonary diseases, and orthopedic morbidities. Fifty-one (51) subjects were evaluated for eligibility, and 39 subjects were excluded after an initial interview since they did not meet the aforementioned inclusion criteria.

Primary outcomes:
measure: Forearm Blood Flow and Vascular Conductance
timeFrame: Up to 2 years
Secondary outcomes:
measure: Blood pressure
timeFrame: Up to 2 years
measure: Heart rate
timeFrame: Up to 2 years
Other outcomes:
Locations:
Study officials:
affiliation: Federal University of Paraíba
name: Maria do Socorro B Santos, Ph.D.
role: STUDY_DIRECTOR
References: