Clinical trial NCT05147870: Outcome After Laparoscopic Surgery for Peptic Ulcer Perforation
Official title: Whether Peritoneal Irrigation Intra-operatively Effects on the Outcome After Laparoscopic Surgery for Peptic Ulcer Perforation
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Intraabdominal Abscess After Procedure
Leakage
Pneumonia
Operation Wound; Infection
Keywords: Laparoscopic surgery
Perforated peptic ulcer
Peritoneal irrigation
Gauze wiping and suction
Intra-abdominal abscess
Lead sponsor: Changhua Christian Hospital
Sponsor class: OTHER
First posted: 2021-12-07
Enrollment: 150
Sex: ALL
Minimum age (years): 18
Maximum age (years): 80
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: COHORT
Time perspective: RETROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: From October 2012 to February 2021, 688 patients presented to the emergency room with a clinical diagnosis of PPU underwent surgery in our hospital. Five hundred and ninety-seven patients were operated in an open approach including 21 patients who were given laparoscopic surgery initially but then intraoperatively converted to laparotomy because the large perforation site cannot be primarily repaired, or the perforation site was difficult to identified or approached. The remaining 91 patients who underwent laparoscopic repair were included in this study.

Brief summary: Despite advances in laparoscopic surgery for perforated peptic ulcer (PPU), intra-abdominal abscess (IAA) is recognized as one of the commonly reported complications with relation to the extent of infectious abdominal contamination. Herein, the investigators report their experience of laparoscopic surgery for PPU with/without peritoneal irrigation and discuss postoperative outcome. The investigators retrospectively examined the electronic medical records of the patients who underwent laparoscopic surgery for perforated peptic ulcer at a single medical center in Taiwan between January 2013 and August 2021. Retrospectively, the investigators would include those patients with clinical diagnosis of PPU who underwent emergent laparoscopic surgery. The patients with previous abdominal surgery, pathologic confirmed malignant ulcer perforation or concomitant ulcer bleeding were excluded. The investigators focused on post-operative complications and outcome after laparoscopic surgery with or without peritoneal irrigation. This information can be important in improving surgical options with respect to risk and potential benefits in this setting.


Eligibility criteria: Inclusion Criteria:

* The patients with clinical diagnosis of PPU underwent laparoscopic repair surgery.

Exclusion Criteria:

* The patients received surgery in an open approach or underwent laparoscopy initially but then intraoperatively converted to laparotomy.

Primary outcomes:
measure: Short-term outcome with wound infection, pneumonia, leakage, and intraabdominal abscess
timeFrame: Through hospitalization, an average of 8 days
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
affiliation: Changhua Christian Hospital, Changhua, 500, Taiwan
name: Lien-Cheng Tsao, M.D.
role: PRINCIPAL_INVESTIGATOR
References: