louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT04430751: Medical Qigong for Mobility and Balance Self-Confidence
Official title: Medical Qigong for Mobility and Balance Self-Confidence
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Falls, Balance Self-confidence
Lead sponsor: Dartmouth-Hitchcock Medical Center
Sponsor class: OTHER
First posted: 2020-06-12
Enrollment: 95
Sex: ALL
Minimum age (years): 50
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The population is aging and increasingly at risk for falls and fractures with substantial consequences to wellbeing, health and costs. Training interventions such as Tai Chi have been demonstrated to help reduce these risks. Tai chi is a subset of both martial and medical qi gong.

This is a prospective intervention study with wait time control that will examine the ability of a manualized medical qi gong training protocol improve balance, gait and health self-confidence.

The intervention is a 12 week manualized medical qi gong training program where students are taught a progressive series of 10 qi gong forms that are designed to build upon each other and restore balance and function. These forms involve both physical movement and visualization.

The Community Balance and Mobility scale (a performance based measure) and Activities-specified Balance Confidence scale (a survey)will be the prime outcome instruments


Eligibility criteria: Inclusion Criteria:

* Adults 50 years of age or older who presented at the two study locations (Massachusetts, Arizona) were considered eligible for participation

Exclusion Criteria:

* Unable to participate in informed consent

Primary outcomes:
measure: Community Balance and Mobility Scale
timeFrame: through study completion, up to 16 weeks
Secondary outcomes:
measure: Activities-specific Balance Confidence Scale
timeFrame: through study completion, up to 16 weeks
Other outcomes:
Locations:
city: Lebanon
country: United States
facility: Dartmouth-Hitchcock medical Center
state: New Hampshire
Study officials:
References:
citation: Stahl JE, Belisle SS, Zhao W. Medical Qigong for Mobility and Balance Self-Confidence in Older Adults. Front Med (Lausanne). 2020 Aug 14;7:422. doi: 10.3389/fmed.2020.00422. eCollection 2020.
Clinical trial NCT03706651: Assessment of Tele-expertise for the Interpretation of MRI Among Neonates With High Risk of Neurological Sequelae
Official title: Assessment of Tele-expertise for the Interpretation of MRI Among Neonates With High Risk of Neurological Sequelae
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Hypoxia, Brain
Lead sponsor: Assistance Publique - Hôpitaux de Paris
Sponsor class: OTHER
Collaborators: name: Agence Regionale de Sante d'Ile de France
First posted: 2018-10-16
Enrollment: 70
Sex: ALL
Maximum age (years): 28
Standard ages: CHILD
Accepts healthy volunteers: no
Observational model: CASE_CONTROL
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Infants hospitalized in neonatology unit

Brief summary: The purpose of the study is to determine whether tele-expertise would be more effective and more cost-effective for the Interpretation of MRI Among Neonates with high risk of neurological sequelae


Eligibility criteria: Inclusion Criteria:

* Less than 28 days of life
* Mandatory to have a medical advice in paediatric neuroradiology for interpretation of brain MRI

Exclusion Criteria:

* None

Primary outcomes:
measure: Time between MRI and decision of intensive care continuation
timeFrame: 1 week after discharge
Secondary outcomes:
measure: Time between MRI and the specialist report
timeFrame: 1 week after discharge
measure: Time between MRI and the discussions with the parents
timeFrame: 1 week after discharge
Other outcomes:
Locations:
city: Le Kremlin Bicêtre
country: France
facility: Service de radiopédiatrie
city: Paris
country: France
facility: Service de Radiopédiatrie. Hôpital Trousseau
city: Paris
country: France
facility: Service de radiopédiatrie. Hôpital Necker
city: Paris
country: France
facility: Service de radiopédiatrie - Hôpital Robert Debré
Study officials:
affiliation: Centre de téléradiologie, Assistance Publique, Hôpitaux de Paris
name: Elisabeth Dion, MD, PhD
role: PRINCIPAL_INVESTIGATOR
affiliation: DRCD URC Eco. Assistance Publique - Hôpitaux de Paris
name: Isabelle Durand-Zaleski, MD, PhD
role: PRINCIPAL_INVESTIGATOR
References:
citation: Larroque B, Ancel PY, Marret S, Marchand L, Andre M, Arnaud C, Pierrat V, Roze JC, Messer J, Thiriez G, Burguet A, Picaud JC, Breart G, Kaminski M; EPIPAGE Study group. Neurodevelopmental disabilities and special care of 5-year-old children born before 33 weeks of gestation (the EPIPAGE study): a longitudinal cohort study. Lancet. 2008 Mar 8;371(9615):813-20. doi: 10.1016/S0140-6736(08)60380-3.
citation: Kidholm K, Ekeland AG, Jensen LK, Rasmussen J, Pedersen CD, Bowes A, Flottorp SA, Bech M. A model for assessment of telemedicine applications: mast. Int J Technol Assess Health Care. 2012 Jan;28(1):44-51. doi: 10.1017/S0266462311000638.
Clinical trial NCT01604551: Membrane Shedding During Septic Shock
Official title: Membrane Shedding During Severe Sepsis and Septic Shock: Pathophysiological and Clinical Relevance
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Septic Shock
Lead sponsor: University Hospital, Strasbourg, France
Sponsor class: OTHER
First posted: 2012-05-23
Enrollment: 100
Sex: ALL
Minimum age (years): 18
Maximum age (years): 85
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Patients with septic shock

Brief summary: Microparticles (MPs) result from plasma cell membrane remodeling and shedding after cell stimulation or apoptosis. MPs are know recognized as a pool of bioactive messengers with emerging role in pathophysiology of immune and cardiovascular diseases. MPs have been characterized during septic shock and may contribute to dissemination of pro-inflammatory and procoagulant mediators. This is a prospective observational study of circulating MPs and blood coagulation in 100 septic shock patients admitted in 3 tertiary hospitals medical ICU at baseline (D1), D2, D3, D4 and D7.


Eligibility criteria: Inclusion Criteria:

* Septic shock
* Informed consent

Exclusion Criteria:

* Class IV heart failure
* Child-Plugh grade C cirrhosis
* Cancer under active treatment
* BMI\>35 kg/m²
* Moribund patient
* DNR decision

Primary outcomes:
Secondary outcomes:
Other outcomes:
Locations:
city: Angers
country: France
facility: Service Réanimation Médicale et Médecine Hyperbare, CHU
city: Mulhouse
country: France
facility: Centre Hospitalier
city: Strasbourg
country: France
facility: Service de Réanimation Médicale, Nouvel Hôpital Civil, Hôpitaux Universitaires
Study officials:
affiliation: Service de Réanimation Médicale, Nouvel Hôpital Civil, Hôpitaux Universitaires de Strasbourg, France
name: Xavier DELABRANCHE, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT01655251: Video Discharge Instructions for Fever and ED Recidivism
Official title: Video Discharge Instructions for Fever and ED Recidivism
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Children Who Present to the ED With Minor Febrile Illnesses
Keywords: children
fever
emergency department
Lead sponsor: Connecticut Children's Medical Center
Sponsor class: OTHER
First posted: 2012-08-01
Enrollment: 273
Sex: ALL
Minimum age (years): 8
Maximum age (years): 18
Standard ages: CHILD
ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: PREVENTION

Brief summary: To evaluate the effect of video discharge instructions on return visits to the ER or ED within 72 hours of the original visit for children with febrile illnesses.

Detailed description: This is a randomized prospective convenience study of children presenting to the ED. Children greater than 8 weeks and up to and including their 18th birthday are enrolled. Patients were randomly assigned to one of two study groups: video + written fever specific discharge instructions and only written fever specific discharge instructions. Parents assigned to the video group watched the DVD in the emergency department (ED) and take it home along with the written instructions. At 72 hours both groups received a phone call asking whether they returned to the ED and the usefulness of discharge instructions (DVD and/or written). Critically ill children and those with chronic medical conditions were excluded. The primary outcome is a return ED visit for fever confirmed in our electronic medical record and questionnaire response. The secondary outcome is reported parental usefulness of the discharge instructions.

Eligibility criteria: Inclusion Criteria:

* Children ages 8 weeks to 18 years
* Presented to the ED with a chief complaint of fever. Fever was defined as a temperature greater than or equal to 100.4⁰F
* English or Spanish speaking
* Working telephone for follow-up call
* Venue to view DVD at home (TV, computer, etc)

Exclusion Criteria:

* Children with a chronic medical illness
* Children with immune-compromising conditions
* Allergies to acetaminophen or ibuprofen
* Previously enrolled
* Admitted at the time of their index ED visit

Primary outcomes:
measure: recidivism
timeFrame: 72 hours
Secondary outcomes:
measure: usefulness
timeFrame: 1 week
Other outcomes:
Locations:
city: Hartford
country: United States
facility: Connecticut Children's Medical Center
state: Connecticut
city: Hartford
country: United States
facility: Connecticut Children's Medical Center
state: Connecticut
Study officials:
References:
Clinical trial NCT02882451: Impact of Pinaverium Bromide on Bile Duct and Pancreatic Duct Cannulation During Endoscopic Retrograde Cholangiopancreatography
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Bile Duct Diseases
Keywords: bile duct
endoscopic retrograde cholangiopancreatography
pinaverium bromide
Lead sponsor: Changhai Hospital
Sponsor class: OTHER
First posted: 2016-08-29
Enrollment: 200
Sex: ALL
Minimum age (years): 18
Maximum age (years): 80
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: Pinaverium bromide can be used to treat symptoms related to irritable bowel syndrome (IBS) and functional disorders of the biliary tract. In this study, pinaverium bromide was compared with Vitamin C for the facilitation of bile duct and pancreatic duct cannulation in patients. The primary outcome was successful deep bile duct cannulation and pancreatic duct canulation. The second outcome was the major papillary orifice,bile juice flow from the papilla, time to achieve deep bile duct cannulation, fluoroscopy time for deep bile duct cannulation,the appearance of the major and minor papillary orifice, pancreatic juice flow from the papilla, time to achieve deep pancreatic duct cannulation, and fluoroscopy time for deep pancreatic duct cannulation in the pinaverium bromide group versus Vitamin C group.


Eligibility criteria: Inclusion Criteria:

1. those with intact native papilla,
2. who underwent endoscopic retrograde choledochopancreatography for bile duct,
3. age≥18 years, ≤80years, and
4. agreement to participate in the study.

Exclusion Criteria:

1. a previous sphincterotomy,
2. previous attempted or unsuccessful endoscopic retrograde choledochopancreatography with papillary manipulation,
3. indwelling biliary or pancreatic stent(s),
4. active acute pancreatitis,
5. active acute pancreatitis
6. altered/postsurgical anatomy,
7. history of gastroparesis,
8. endoscopic retrograde choledochopancreatography for sphincter of Oddi's sphincter(SO) manometry,
9. known tumor of the major duodenal papilla, and
10. patients with any medication probably affecting SO motility

Primary outcomes:
measure: cannulation time for deep bile duct cannulation and pancreatic duct cannulation
timeFrame: 2 days
Secondary outcomes:
measure: bile juice flow from the major papilla and pancreatic juice flow from the major papilla
timeFrame: 2 days
measure: appearance of the major papillary orifice
timeFrame: 2 days
Other outcomes:
Locations:
city: Shanghai
country: China
facility: Changhai Hospital, Second Military Medical University
Study officials:
References:
Clinical trial NCT01247051: Comparison of Two Different Heart-lung Machine Filling Methods: Precoating Versus Colloidal Fluids
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Priming
Cardiac Surgery
Cardio Pulmonary Bypass
Keywords: priming
cardiac surgery
cardio pulmonary bypass
precoating
Lead sponsor: Johann Wolfgang Goethe University Hospital
Sponsor class: OTHER
First posted: 2010-11-24
Enrollment: 90
Sex: ALL
Minimum age (years): 78
Maximum age (years): 95
Standard ages: OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The study is a single-center, randomized, un-blinded treatment study in which patients (\>78 years) with the use off a heart-lung machine were provided into two study arms.

Patient wit "precoating" have a filling of the machine with their own blood. In the comparator arm, a standard priming is used.


Eligibility criteria: Inclusion Criteria:

* Age \> 78 years
* CPB

Exclusion Criteria:

* Hb \<12 mg/dl
* Off pump surgery

Primary outcomes:
measure: blood loss
timeFrame: 24 hours
Secondary outcomes:
measure: Inflammatory response
timeFrame: one week
Other outcomes:
Locations:
city: Frankfurt
country: Germany
facility: Goethe University
state: Hessen
Study officials:
References:
Clinical trial NCT04203251: Evaluation of TTE Utilization in Medical Surgery Step-Down Unit
Official title: Evaluation of TTE Utilization in Medical Surgery Step-Down Unit: Use of AI Assisted Point-of-Care Echo With Guidance Technology
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Cardiac Disease
Keywords: Artificial Intelligence
Cardiac Monitoring
Lead sponsor: Caption Health, Inc.
Sponsor class: INDUSTRY
First posted: 2019-12-18
Enrollment: 100
Sex: ALL
Minimum age (years): 18
Maximum age (years): 99
Standard ages: ADULT
OLDER_ADULT
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Patients in the medical surgery step down unit at UCSF.

Brief summary: This is a non-randomized, un-blinded study to evaluate Caption Health guidance software in patients in the medical surgery step-down unit. Patients will be scanned by a trained hospitalist and up to 4 standard views will be obtained per participant: PLAX, PSAX-PM, AP4 and SubC4. Observations will be made regarding human factors and performance of the device.


Eligibility criteria: Inclusion Criteria: .

* Patients ≥18 years old
* Patients in the medical surgery step-down clinical setting
* Patients who consent to participating in the study

Exclusion Criteria: .

* ● Patients with emergent or urgent episodes of injury and illness that can lead to death or disability without rapid intervention

  * Unable to lie flat for study
  * Patients experiencing a known or suspected acute cardiac event at the time of evaluation
  * Patients with severe chest wall abnormalities
  * Patients who have undergone pneumonectomy
  * Patients with recent abdominal surgery
  * Patients unwilling or unable to give written informed consent
  * Principal Investigator determination to exclude the subject from participation
  * Investigators also have the right to withdraw patient from the study in the event of illness, adverse events, or other reasons concerning the health or well-being of the patient, or in the case of non-compliance.

Primary outcomes:
measure: Mean time to acquire images
timeFrame: Up to 3 months
measure: Percentage of attempted studies with clinically useful images
timeFrame: Up to 3 Months
Secondary outcomes:
Other outcomes:
Locations:
city: San Francisco
country: United States
facility: University of California San Francisco
state: California
Study officials:
References:
Clinical trial NCT01809951: Isomil Post Marketing Observational Study
Official title: A Prospective, Open-label, Post-marketing Observational Study to Document the Use of Soy-based Infant Formula With Low Chain Polyunsaturates (LCP) in Infants With Symptoms Suggestive to Cow's Milk Allergy
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Cow's Milk Allergy
Lead sponsor: Indonesia University
Sponsor class: OTHER
First posted: 2013-03-13
Enrollment: 534
Sex: ALL
Minimum age (years): 6
Maximum age (years): 12
Standard ages: CHILD
Accepts healthy volunteers: no
Observational model: CASE_ONLY
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Infants with symptoms suggestive adverse reactions to cow's milk protein

Brief summary: The use of soy-isolate protein based formula for infants with cow's milk protein intolerance is common in Indonesia, however, there has not been any systematic collection of clinical data to determine the formula's gastrointestinal tolerance, and the parent's perceptions regarding the formula.


Eligibility criteria: Inclusion Criteria:

* infants of 6 - 12 months of age
* full term infants
* birth weight more than 2500 grams
* infants developed symptoms suggestive adverse reactions to cow's milk protein in the investigator's clinical judgements
* subject is prescribed a soy-based infant formula by physician

Exclusion Criteria:

* established/suspected hypersensitivity fo soy
* presence of adverse reactions to cow's milk caused by coincidental infections or other systemic disease
* history of blood group incompatibility, premature delivery, HIV infections, major congenital abnormalities, systemic diseases
* presence of severe gastrointestinal disorder
* subject is participating in any interventional clinical study

Primary outcomes:
measure: Parent's acceptance in the feeding of a soy-based infant formula with LCP in infants with symptoms suggestive adverse reactions to cow milk protein
timeFrame: 4-week
Secondary outcomes:
measure: percentage of infants with gastrointestinal adverse events
timeFrame: 4-week
measure: percentage of infants with adverse events
timeFrame: 4-week
Other outcomes:
Locations:
city: Jakarta
country: Indonesia
facility: Divisi Alergi Imunologi FKUI RSCM
Study officials:
affiliation: Division of allergy and Immunology, Department of Child Health, Faculty of Medicine, Universitas Indonesia
name: Zakiudin Munasir, MD, PhD
role: PRINCIPAL_INVESTIGATOR
affiliation: RS Sardjito, Jl Kesehatan No 1 Yogyakarta
name: Sumadiono, MD, PhD
role: STUDY_CHAIR
affiliation: Allergy Immunology Working Unit, East Java Branch of Indonesian Pediatric Society
name: Anang Endaryanto, MD, PhD
role: STUDY_CHAIR
affiliation: Sub Divisi Alergi Imunologi IKA FKUI, Jakarta
name: Dina Muktiarti, MD
role: STUDY_CHAIR
affiliation: RSUP Sanglah, Jl Kesehatan No 1-10 Denpasar Bali
name: Dewi Kumara Wati, MD, PhD
role: STUDY_CHAIR
affiliation: RS Hasan Sadikin Jl Pasteur No 38 Bandung
name: Budi Setiabudiawan, MD, PhD
role: STUDY_CHAIR
References:
Clinical trial NCT04664751: Incidence of Compliance to the ASA Preoperative Fasting Guidelines in Elective Surgery
Official title: Incidence of Compliance to the ASA Preoperative Fasting Guidelines in Elective General Surgery.
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Compliance, Treatment
Keywords: Compliance
NPO guidelines
Lead sponsor: Mahidol University
Sponsor class: OTHER
First posted: 2020-12-11
Enrollment: 309
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Patients scheduled for elective surgery requiring general anesthesia, regional anesthesia, or procedural sedation and analgesia

Brief summary: Patients scheduled for elective surgery with general anesthesia, regional anesthesia, or procedural sedation and analgesia will be interviewed about the last time having

* clear liquid drink
* light meal
* regular meal


Eligibility criteria: Inclusion Criteria:

* Scheduled for elective surgery requiring general anesthesia, regional anesthesia, or procedural sedation and analgesia.

Exclusion Criteria:

* Patients with the order of NPO after midnight.
* Patients with pregnancy

Primary outcomes:
measure: compliance to NPO guideline
timeFrame: 8 hour
Secondary outcomes:
Other outcomes:
Locations:
city: Bangkok
country: Thailand
facility: Faculty of Medicine Siriraj Hospital, Mahidol University
Study officials:
affiliation: Mahidol University
name: Sirilak Suksompong, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT03732651: The Impact of Non-pulsatile Blood Flow on CO2-Reactivity
Official title: The Impact of Non-pulsatile Perfusion on Cerebral Blood Flow and Brain Oxygenation
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Cerebrovascular Circulation
Lead sponsor: Medical University of Vienna
Sponsor class: OTHER
First posted: 2018-11-06
Enrollment: 32
Sex: ALL
Minimum age (years): 15
Maximum age (years): 75
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NON_RANDOMIZED
Intervention model: CROSSOVER
Intervention model description: Each patient served as his own control.
Primary purpose: BASIC_SCIENCE

Brief summary: The investigators hypothezised that CO2-reactivity of cerebral vessels is affected by systemic non-pulsatile blood flow. Patients undergoing elective cardiac surgery with CPB were enrolled in this prospective case control study. Blood flow velocity in the middle cerebral artery as well as regional cerebral oxygenation was determined during step changes of PaCO2 between 30, 40, and 50 mmHg. Measurements were conducted intraoperatively during non-pulsatile as well as postoperatively after admission to the ICU under pulsatile blood flow.


Eligibility criteria: Inclusion Criteria:

* undergoing elective cardiac surgery with cardiopulmonary bypass

Exclusion Criteria:

* Carotid artery stenosis (\> 50%)
* Neurological pathologies
* COPD with CO2 retention
* Women of childbearing age

Primary outcomes:
measure: CO2- Reactivity of cerebral vessels during cardiopulmonary bypass using nonpulsatile blood flow and postoperative on ICU under physiological pulsatile blood flow
timeFrame: first time-point: intraoperative, during cardiopulmonary bypass, duration up to 300minutes. Second time-point: on ICU, postoperatively under pulsatile blood flow, duration of measurement up to 100minutes for each patient
Secondary outcomes:
Other outcomes:
Locations:
city: Vienna
country: Austria
facility: medical University of Vienna
Study officials:
References:
citation: Veraar CM, Rinosl H, Kuhn K, Skhirtladze-Dworschak K, Felli A, Mouhieddine M, Menger J, Pataraia E, Ankersmit HJ, Dworschak M. Non-pulsatile blood flow is associated with enhanced cerebrovascular carbon dioxide reactivity and an attenuated relationship between cerebral blood flow and regional brain oxygenation. Crit Care. 2019 Dec 30;23(1):426. doi: 10.1186/s13054-019-2671-7.