Clinical trial NCT05936918: Application of Transcutaneous Electrical Acupoint Stimulation in Laparoscopic Cholecystectomy
Official title: Effects of Transcutaneous Electrical Acupoint Stimulation Combined With Transverse Abdominis Plane Block on Perioperative Pain and Early Postoperative Recovery in Patients Undergoing Laparoscopic Cholecystectomy
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Pain Postoperative
Postoperative Recovery
Keywords: Transcutaneous electrical acupoint stimulation
Postoperative pain
Visceral pain
Early recovery after surgery
Lead sponsor: Yangzhou University
Sponsor class: OTHER
First posted: 2023-07-10
Enrollment: 120
Sex: ALL
Minimum age (years): 18
Maximum age (years): 65
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Intervention model description: The study was primarily a randomized controlled study in which patients were randomly assigned to each group.
Primary purpose: PREVENTION

Brief summary: To explore the application of transcutaneous electrical acupoint stimulation combined with transverse abdominis plane block in Laparoscopic cholecystectomy, in order to reduce postoperative pain and promote postoperative recovery.

Detailed description: Percutaneous electrical acupoint stimulation has been applied in preoperative prophylaxis, intraoperative anesthesia and postoperative rehabilitation, and can reduce perioperative anxiety, improve the efficacy of preoperative smoking cessation and alcohol abstinence, and shorten the preoperative fasting time. During surgery, it can reduce the amount of anesthetic drugs, anti-inflammatory and anti-stress effects, stabilize circulation, and protect important organs; After surgery, improve the speed and quality of wake-up of patients, promote the recovery of maintenance function, regulate immune function, and reduce postoperative adverse reactions such as postoperative pain, postoperative nausea and vomiting, postoperative urinary retention, etc. As one of the common nerve blocks, transverse abdominis block is used clinically, and its main function is to relieve perioperative pain and reduce the amount of traumatic stress and analgesic drugs

Eligibility criteria: Inclusion Criteria:

* American Society of Anesthesiologists (ASA) class I and II
* Age 18-65 years
* Laparoscopic cholecystectomy for the first time
* There is no rupture, infection in the acupoint pasting site
* The patient knows and signs the informed consent form

Exclusion Criteria:

* People with visual impairment, hearing impairment and alcoholism
* History of diabetes, myocardial infarction or cerebrovascular accident, liver and kidney dysfunction
* Those who are allergic to non-steroidal drugs, anticholinergic drugs, and anesthetic drugs
* Those who are unable to cooperate or refuse to participate in the research or request to withdraw during the research process
* Those with contraindications to percutaneous electrical stimulation, including local skin damage, infection or implantation of electrophysiological devices in the body

Primary outcomes:
measure: VAS(visual analogue scale) score
timeFrame: The day before surgery
measure: VAS(visual analogue scale) score
timeFrame: After the operation 30minute
measure: VAS(visual analogue scale) score
timeFrame: After the operation 6hour
measure: VAS(visual analogue scale) score
timeFrame: After the operation 12hour
measure: VAS(visual analogue scale) score
timeFrame: After the operation 24hour
measure: VAS(visual analogue scale) score
timeFrame: After the operation 48hour
Secondary outcomes:
measure: Postoperative nausea and vomiting
timeFrame: The day before surgery; After the operation 24hours, 48hours
measure: Early postoperative recovery of quality
timeFrame: The day before surgery; After the operation 24hours, 48hours
measure: Exhaust and bowel movements
timeFrame: After the operation 24hours, 48hours
measure: Concentration of serum interleukin-6
timeFrame: the day before surgery; When entering the operating room; 10minutes after peeling; 5 minutes after the operation; The first day after surgery
measure: Concentration of serum cortisol
timeFrame: the day before surgery; When entering the operating room; 10minutes after peeling; 5 minutes after the operation; The first day after surgery
measure: Concentration of serum C-reactive protein
timeFrame: the day before surgery; When entering the operating room; 10minutes after peeling; 5 minutes after the operation; The first day after surgery
Other outcomes:
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