louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT05867199: Effects of Action Observation Therapy and Motor Imagery Administered During Immobilization Period After Surgical Fixation of Distal Radius
Official title: Effects of Action Observation Therapy and Motor Imagery Administered During Immobilization Period After Surgical Fixation of Distal Radius
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Distal Radius Fracture
Lead sponsor: Istituto Clinico Humanitas
Sponsor class: OTHER
First posted: 2023-05-19
Enrollment: 40
Sex: ALL
Minimum age (years): 18
Maximum age (years): 80
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: SUPPORTIVE_CARE

Brief summary: The goal of this trial is to verify the effectiveness of Motor Imagery and Action Observation Training in subjects undergoing surgery for distal radius fracture fixation. The main question it aims to answer is:

- can action observation and motor imagery training administered during immobilisation period improve functional outcome after distal radius fracture fixation? Participants will be asked to perform hand dexterity test and grip and pinch strength evaluation Subjects assigned to control group will follow standard care


Eligibility criteria: Inclusion Criteria:

* Right handed subjects
* Subjects after surgical distal radius fracture fixation

Exclusion Criteria:

* Concomitant fractures of upper limbs
* Pathological fractures
* Cognitive or psychiatric disorders
* Neurological or reumatici diseases

Primary outcomes:
measure: Change of Purdue Pegboard Test score
timeFrame: After surgery (T0); 3 weeks after surgery (T1); 8 weeks after surgery (T2); 6 motnhs after surgery (T3)
Secondary outcomes:
measure: Change of Grip test
timeFrame: After surgery (T0); 3 weeks after surgery (T1); 8 weeks after surgery (T2); 6 motnhs after surgery (T3)
measure: Change of Pinch test
timeFrame: After surgery (T0); 3 weeks after surgery (T1); 8 weeks after surgery (T2); 6 motnhs after surgery (T3)
measure: Change of Range of motion
timeFrame: After surgery (T0); 3 weeks after surgery (T1); 8 weeks after surgery (T2); 6 motnhs after surgery (T3)
Other outcomes:
measure: Change of Patient Rated Wrist Hand Evaluation
timeFrame: After surgery (T0); 3 weeks after surgery (T1); 8 weeks after surgery (T2); 6 motnhs after surgery (T3)
Locations:
city: Rozzano
country: Italy
facility: Istituto Clinico Humanitas
state: Milan
Study officials:
References:
Clinical trial NCT02908399: Thermal Images on Smartphones to Diagnose Bacterial Pneumonia in Children in Pakistan
Official title: Thermal Images on Smartphones to Diagnose Bacterial Pneumonia in Children in Pakistan
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Infections - Bacterial
Pneumonia - Bacterial
Lead sponsor: Massachusetts General Hospital
Sponsor class: OTHER
Collaborators: name: United States Agency for International Development (USAID)
First posted: 2016-09-21
Enrollment: 250
Sex: ALL
Maximum age (years): 18
Standard ages: CHILD
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: DIAGNOSTIC

Brief summary: This is a prospective study of up to 250 participants, from birth to 18 months, who have already had a chest x-ray while a patient at the National Institute of Health (NICH) in Karachi, Pakistan. Participants will include both males and females as well as all races and ethnicities. Participants will have thermal pictures of their chest taken by trained study staff using a Smartphone and a FLIR ONE attachment. Thermal images will be read by trained radiologists to determine if bacterial pneumonia is present. Results of the thermal image will then be compared to the results of the chest x-ray. If additional images of the chest or other areas of suspected related infection are available, additional thermal images will be taken of the same location within 24 hours of the other image.


Eligibility criteria: Inclusion Criteria:

* 18 months or younger;
* patient at NICH Hospital in Karachi, Pakistan;
* had chest x-ray within last 24 hours to determine diagnosis of bacterial pneumonia;
* consent obtained from one parent

Exclusion Criteria:

* thermal image cannot be done within 24 hours of chest x-ray

Primary outcomes:
measure: diagnosis of bacterial pneumonia
timeFrame: 24 hours
Secondary outcomes:
measure: diagnosis of additional site of infection possibly related to bacterial pneumonia
timeFrame: up to a maximum of 28 days after original chest x-ray to diagnose pneumonia is taken
Other outcomes:
Locations:
city: Karachi
country: Pakistan
facility: National Institute of Child Health
Study officials:
affiliation: Massachusetts General Hospital
name: Patricia L Hibberd, MD, PhD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT00576199: A Study of Avastin (Bevacizumab) and Transarterial Chemoembolisation (TACE) Treatment in Patients With Liver Cancer
Official title: A Phase II Single Arm, Multi-centre Study of Bevacizumab (Avastin®) Pre- and Post-transarterial Chemoembolisation (TACE) Treatment for Localized Unresectable Hepatocellular Carcinoma (HCC)
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE2
Conditions: Liver Cancer
Lead sponsor: Hoffmann-La Roche
Sponsor class: INDUSTRY
First posted: 2007-12-19
Enrollment: 30
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: TREATMENT

Brief summary: This single-arm, open-label study assessed the efficacy and safety of Avastin (bevacizumab) treatment combined with transarterial chemoembolisation (TACE) in patients with localized unresectable liver cancer. Patients were treated with TACE at 8 or 10 week intervals for 4 sessions (continuation depended on investigator's discretion). Avastin 5 mg/kg intravenously was administered 24-48 hours prior to each TACE session and every 2 weeks between the TACE sessions until disease progression.


Eligibility criteria: Inclusion Criteria:

* Adult patients, ≥ 18 years of age.
* Liver cancer, not suitable for resection.
* At least 1 measurable lesion, and overall tumor lesions occupying \< 50% of liver volume
* Eastern Cooperative Oncology Group (ECOG) performance status 0-2.

Exclusion Criteria:

* Patients receiving concurrent radiotherapy or immunotherapy.
* Patients who have received previous chemotherapy, biological agents, or radiotherapy.
* Prior transarterial chemoembolisation (TACE) or transarterial embolisation (TAE).
* Prior liver transplantation or liver resection.
* Current or recent (within 10 days of study start) use of full-dose anticoagulants for therapeutic purposes.
* Patients with high risk esophageal/gastric varices.

Primary outcomes:
measure: Progression-free Survival
timeFrame: Baseline to the end of the study (up to 3 years, 3 months)
Secondary outcomes:
measure: Percentage of Participants With an Objective Response
timeFrame: Baseline to the end of the study (up to 3 years, 3 months)
measure: Time to Progression
timeFrame: Baseline to the end of the study (up to 3 years, 3 months)
measure: Overall Survival
timeFrame: Baseline to the end of the study (up to 3 years, 3 months)
measure: Percentage of Participants With a Best Overall Response of Complete Response, Partial Response, or Stable Disease
timeFrame: Baseline to the end of the study (up to 3 years, 3 months)
measure: Tumor Necrosis
timeFrame: Baseline to the end of the study (up to 3 years, 3 months)
Other outcomes:
Locations:
city: Hong Kong
country: Hong Kong
city: Hong Kong
country: Hong Kong
city: Hong Kong
country: Hong Kong
Study officials:
affiliation: Hoffmann-La Roche
name: Clinical Trials
role: STUDY_DIRECTOR
References:
Clinical trial NCT02458599: Efficacy Study of Protein Supplementation in Attenuating the Decline in Performance After Strenuous Concurrent Exercise
Official title: A Study to Evaluate the Effects of Protein Supplementation in Attenuating the Decline in Performance Following Strenuous Concurrent Exercise
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Sports Nutritional Sciences
Lead sponsor: GlaxoSmithKline
Sponsor class: INDUSTRY
First posted: 2015-06-01
Enrollment: 24
Sex: MALE
Minimum age (years): 18
Maximum age (years): 35
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: SUPPORTIVE_CARE

Brief summary: This study is designed to investigate whether protein supplementation can improve recovery of muscle function following a strenuous combination of both endurance and resistance exercise. It will specifically investigate the effect of protein supplementation on the recovery of strength, power and endurance exercise performance, along with measures of damage and inflammation of the muscle.


Eligibility criteria: Inclusion Criteria:

* Understanding of the study procedures, restrictions and willingness to participate as evidenced by voluntary informed consent form and has received signed and dated copy of the informed consent form
* Male participants; age between 18 to 35 years, inclusive
* Well trained endurance cyclist (competing at a minimum of Category 3 road-racing/estimated 10 mile TT of \<23 minutes), with a training history \>1 year
* Good general and mental health

Exclusion Criteria:

* Currently taking any nutritional supplements, polyphenols or beta-blockers, Non-steroidal anti-inflammatory drugs (NSAIDs), recreational drugs
* Known or suspected intolerance or hypersensitivity to the study material or any of their stated ingredients
* Allergy to milk or wheat products
* Heart or any other medical condition that may contra-indicate participants from taking part in high intensity or exhaustive physical activity
* Previous participation in this study; another clinical study or receipt of an investigational drug within 30 days of the screening visit; participation in another study involving a protocol to elicit Exercise-Induced Muscle Damage (EIMD) within 6 months of the screening visit

Primary outcomes:
measure: Isometric Maximal Voluntary Contraction (MVC) Assessment
timeFrame: 96 hours (h)
measure: Counter Movement Jump (CMJ) Assessment
timeFrame: 96 h
measure: 16.1 Kilometer (km) Cycling Time Trial (TT) Assessment
timeFrame: 96 h
Secondary outcomes:
measure: Serum Creatine Kinase Analysis
timeFrame: 96 h
measure: Serum C-Reactive Protein Analysis
timeFrame: 96 h
measure: Perceived Muscle Soreness Assessment
timeFrame: 96 h
Other outcomes:
Locations:
city: Brentford
country: United Kingdom
facility: GSK Investigational Site
Study officials:
affiliation: GlaxoSmithKline
name: GSK Clinical Trials
role: STUDY_DIRECTOR
References:
Clinical trial NCT03729999: Ultrasound to Verify Lung-isolation During Single-lung Ventilation
Official title: Ultrasound to Verify Lung-isolation During Single-lung Ventilation
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Thoracic Diseases
Lead sponsor: Nationwide Children's Hospital
Sponsor class: OTHER
First posted: 2018-11-05
Enrollment: 40
Sex: ALL
Maximum age (years): 18
Standard ages: CHILD
ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: OTHER

Brief summary: The purpose of the current study is to prospectively evaluate the usefulness of thoracic ultrasonography in demonstrating effective lung isolation during single-lung ventilation (SLV) in the pediatric patient. The primary hypothesis is that ultrasonography will accurately verify lung separation during SLV, as compared to fiberoptic bronchoscope (FOB).


Eligibility criteria: Inclusion Criteria:

* Requiring single lung ventilation for thoracic surgery

Exclusion Criteria:

* None

Primary outcomes:
measure: The Accuracy of Using Ultrasound to Assess Lung Isolation by Visualizing Lung Movement or Lack Thereof of Both the Operative and Non-operative Lung Fields.
timeFrame: Within 5 minutes of intubation and single lung ventilation device placement
measure: Time to Confirm Lung Isolation
timeFrame: Within 5 minutes of intubation and single lung ventilation device placement
Secondary outcomes:
Other outcomes:
Locations:
city: Columbus
country: United States
facility: Nationwide Children's Hospital
state: Ohio
Study officials:
References:
Clinical trial NCT01873599: Impact of an Online Positive Affect Journaling Intervention
Official title: Impact of an Online Positive Affect Journaling Intervention
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Stress
Lead sponsor: Milton S. Hershey Medical Center
Sponsor class: OTHER
Collaborators: name: Penn State University
First posted: 2013-06-10
Enrollment: 70
Sex: ALL
Minimum age (years): 21
Maximum age (years): 80
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: In this study the investigators plan to recruit 70 patients reporting high levels of stress to test the impact of Positive Affect Journaling. Patients randomized to use the online intervention will be asked to journal about one of seven topics, several days each week, for three months. The topics (e.g., "What went well") are designed to help the individual focus on some positive aspect of their life or themselves over the past day. Each topic is based on prompts shown to be effective in studies of up to one week in duration. In the summer of 2012, our research team pilot tested each prompt with 20 patients with high levels of anxiety, which led to important changes to the prompts, to increase their potential impact. The main aim is to understand the impact of Positive Affect Journaling on psychological distress, as measured by the National Health Interview Survey.


Eligibility criteria: Inclusion Criteria:

* Fluently speaks, writes, and read English
* Report elevated levels of stress
* Be between 21-80 years of age
* Have access to the Internet
* Have an ECOG Performance Status of 0 (Fully active) through 3 (Limited self-care)

Exclusion Criteria:

* High risk for suicidality on the Structured Clinical Interview for DSM Disorders (SCID).
* Pregnant or planning to get pregnant in the next 3 months
* Moving in the next 6 months

Primary outcomes:
measure: National Health Interview Survey
timeFrame: 3 month follow up
Secondary outcomes:
measure: Brief Resilience Scale
timeFrame: 3 month follow up
measure: Perceived Stress Scale
timeFrame: 3 month follow up
measure: Satisfaction with Life scale
timeFrame: 3 month follow up
measure: Social Provisions Scale
timeFrame: 3 month follow up
measure: Healthy Days score
timeFrame: 3 month follow up
measure: Positive and Negative Affect Schedule score
timeFrame: 3 month follow up
measure: Cancer Quality of Life
timeFrame: 3 month follow up
Other outcomes:
Locations:
city: Hershey
country: United States
facility: Penn State Hershey Medical Center
state: Pennsylvania
Study officials:
affiliation: Milton S. Hershey Medical Center
name: Christopher Sciamanna
role: PRINCIPAL_INVESTIGATOR
References:
citation: Smyth JM, Johnson JA, Auer BJ, Lehman E, Talamo G, Sciamanna CN. Online Positive Affect Journaling in the Improvement of Mental Distress and Well-Being in General Medical Patients With Elevated Anxiety Symptoms: A Preliminary Randomized Controlled Trial. JMIR Ment Health. 2018 Dec 10;5(4):e11290. doi: 10.2196/11290.
Clinical trial NCT01783899: Clinical Evaluation of Hemospray in Hemostasis of Active Variceal Bleeding
Official title: Clinical Evaluation of Hemospray in Hemostasis of Active Variceal Bleeding
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Variceal Hemorrhage
Lead sponsor: Theodor Bilharz Research Institute
Sponsor class: OTHER
Collaborators: name: Université Libre de Bruxelles
First posted: 2013-02-05
Enrollment: 30
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: TREATMENT

Brief summary: The objective of this study is to assess the effectiveness of Hemospray in achieving initial hemostasis and decreased rate of re-bleeding in patients of acute variceal bleeding.


Eligibility criteria: Inclusion criteria :

* 18 Years and older
* Bleeding Esophageal and / or Gastric varices

Exclusion Criteria:

* Patient is: \< 18 years of age
* Unable to consent
* Contraindicated to undergo endoscopy,
* Already hospitalized for another illness
* Pregnant or lactating
* Patients with altered post-surgical anatomy of the stomach
* Previously placed intrahepatic portosystemic shunt
* Patient treated by other endoscopic or surgical modalities within 7 days prior to the intended application of Hemospray

Primary outcomes:
measure: Safety
timeFrame: 24 hours
Secondary outcomes:
measure: Effectiveness
timeFrame: 24 hours
Other outcomes:
Locations:
city: Brussels
country: Belgium
facility: Erasme Hospital , ULB
city: Giza
country: Egypt
facility: Theodor Bilharz Research Institute
Study officials:
affiliation: Université Libre de Bruxelles
name: Mostafa Ibrahim, MD
role: PRINCIPAL_INVESTIGATOR
References:
citation: Ibrahim M, El-Mikkawy A, Mostafa I, Deviere J. Endoscopic treatment of acute variceal hemorrhage by using hemostatic powder TC-325: a prospective pilot study. Gastrointest Endosc. 2013 Nov;78(5):769-73. doi: 10.1016/j.gie.2013.07.037.
Clinical trial NCT04749342: Complete Decongestive Therapy Versus Compression Bandaging in Advanced Secondary Lymphedema
Official title: Complete Decongestive Therapy Versus Compression Bandaging in Advanced Secondary Lymphedema
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Edema Due to Obstruction of Lymph Vessels or Excision of Lymph Nodes
Lead sponsor: Cairo University
Sponsor class: OTHER
First posted: 2021-02-11
Enrollment: 60
Sex: ALL
Minimum age (years): 40
Maximum age (years): 55
Standard ages: ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: FACTORIAL
Intervention model description: The purpose of this report is to compare short-term outcomes of complete decongestive therapy and compression bandaging on patients with advanced secondary upper and lower extremity lymphedema.
Primary purpose: TREATMENT

Brief summary: The purpose of this study is to:

Find out the efficacy of using complete decongestive physiotherapy on limb volume in advanced secondary upper and lower extremity lymphedema patients.

Find out the efficacy of compression bandaging on limb volume in advanced lymphedema patients.

This study was conducted to compare between the efficacy of complete decongestive therapy (CDT) and compression bandaging in advanced secondary lower extremity lymphedema.

Detailed description: The study was conducted at the department of plastic surgery, Kasr Al-Ainy hospital. Sixty patients of both genders aged from 40 to 55 years old were participated in this study, and they were randomly assigned to two study groups.

Group I: Thirty patients received CDT (60 min of manual lymph drainage MLD, compression bandaging, exercises, and skin care).

Group II: Thirty patients received compression bandaging alone. The same bandaging scheme used for both groups. The therapy included 12 interventions performed 5 days a week, during the first two weeks in addition to another successive two sessions at the third week, i.e., for a total of twelve sessions.

Evaluation of limb volume using water volumetry and 4-cm truncated cone circumferential measurements were done before treatment application, after 6 sessions (post 1) and after 12 sessions (post 2).

Eligibility criteria: Inclusion Criteria:

Patients with lower limb lymphedema (stage II and III) secondary lymphedema aged from 40 to 55 years old, with BMI less than 35 and duration of illness ranged from 3-9 years were included in the study

Exclusion Criteria:

the patients were excluded if they have acute erysipelas, acute thrombophlebitis phlebothrombosis and decompensated heart failure.

Primary outcomes:
measure: Limb Volume
timeFrame: 1 Month
Secondary outcomes:
Other outcomes:
Locations:
city: Cairo
country: Egypt
facility: cairo University
state: Dokky, Giza
Study officials:
affiliation: Cairo University
name: Ahmed Mohamed Abdelrauf, Assistant Lecturer
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT06708442: Guided Narrative Technique After Coronavirus Outbreak Influencing Positive and Negative Emotions and Cognition for Children--A Randomized Controlled Trial
Official title: Guided Narrative Technique After Coronavirus Outbreak Influencing Positive and Negative Emotions and Cognition for Children--A Randomized Controlled Trial
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Anxiety and Depression
Lead sponsor: Peking University
Sponsor class: OTHER
First posted: 2024-11-27
Enrollment: 220
Sex: ALL
Minimum age (years): 8
Maximum age (years): 14
Standard ages: CHILD
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: PREVENTION

Brief summary: At the beginning of 2020, the COVID-19 broke out in Wuhan, raging across the country quickly afterwards. As a sudden public health emergency, this epidemic caused some stress reactions (including emotional, cognitive, and behavioral reactions) in children. These stress responses, in moderation, may be beneficial as a response to the challenge. However, excessive, and inappropriate stress responses may damage children's mental health, immune function, and daily function.

School-based CBT intervention is effective in alleviating children and adolescent anxiety. However, the effect last only shortly. Therefore, adding a new intervention component is necessary. Guided Narrative Technique (GNT) is an intervention focusing on narrative coherence and emotional expression. It has writing and drawing versions. The writing version was developed from Expressive Writing and has a significant effect on the improvement of various negative emotions and negative cognitions of traumatized individuals.

In this study, a randomized controlled experiment will be implemented. All participants will take a CBT course first. Then, they will be asked to write or draw about the epidemic or other life events using GNT. The study will explore the impact of CBT course combined with GNT on negative emotions and cognition of children after such a public crisis.


Eligibility criteria: Inclusion Criteria:

* have the ability to read and write in Chinese

Exclusion Criteria:

* no parental consent

Primary outcomes:
measure: Anxiety and depression
timeFrame: From enrollment to the 6-month follow-up
Secondary outcomes:
measure: PTSD for children
timeFrame: From enrollment to the 6-month follow-up
Other outcomes:
measure: Emotion awareness
timeFrame: From enrollment to the 6-month follow-up
Locations:
city: Beijing
country: China
facility: Peking University
Study officials:
References: