Clinical trial NCT04144647: The Relationship Between Dual-task Gait Performance, Physical Activity Levels, Sleep and Aging in Healthy Adults
Official title: The Relationship Between Dual-task Gait Performance, Physical Activity Levels, Sleep and Aging in Healthy Adults
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Healthy
Adults
Keywords: dual-tasking
CANTAB
Gait
Cognition
Sleep
activity
Lead sponsor: King's College London
Sponsor class: OTHER
First posted: 2019-10-30
Enrollment: 100
Sex: ALL
Minimum age (years): 18
Maximum age (years): 80
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: NA
Intervention model: SINGLE_GROUP
Intervention model description: 100 healthy participants aged between 18-80 years old are recruited for this study.

All individuals that express interest in this study, will be provided with a Participant Information Sheet (PIS) either by email or hard copy by post.

All prospective subjects will be screened for matching of inclusion criteria. After a potential participant contacts the PhD student, Ms Viktoria Azoidou, regarding his/her interest in participating in the study, the person will be asked to complete the screening questionnaire via telephone or email as per each individual's preference regarding eligibility criteria. If after screening, a potential participant meets the eligibility criteria, an appointment will be arranged to discuss any concerns or answer any questions participants may have regarding the PIS, then sign the written consent form and be assessed attend the research laboratory for the single testing session.
Primary purpose: SCREENING

Brief summary: The co-ordination and control of body segments are integral in providing and maintaining postural stability. It is widely accepted that attentional demands for postural control are placed upon the individual, but these vary according to the nature of the task, the age of the individual and their postural stability. It is thought that divided attention (a technique whereby two tasks are performed at the same time whilst rapidly switching attention between the two tasks) is commonly used when multi-tasking. Divided attention may have important clinical implications to falls risk, in that older adults that experience falls have increased difficulty in switching attention between tasks such as walking and talking. Dual tasking paradigms which present postural and cognitive tasks are often used to test attentional demands for posture control and interference between the two tasks. At present it is not known what impact balance confidence, sleep, activity levels or cognitive ability impact on a person's ability to multi-task when performing complex walking tasks that reflect the complexity of mobilising in real-life situations.

Detailed description: The co-ordination and control of body segments are integral in providing and maintaining postural stability. It is widely accepted that attentional demands for postural control are placed upon the individual, but these vary according to the nature of the task, the age of the individual and their postural stability. It is thought that divided attention (a technique whereby two tasks are performed at the same time whilst rapidly switching attention between the two tasks) is commonly used when multi-tasking. Divided attention may have important clinical implications to falls risk, in that older adults that experience falls have increased difficulty in switching attention between tasks such as walking and talking. Dual tasking paradigms which present postural and cognitive tasks are often used to test attentional demands for posture control and interference between the two tasks. At present it is not known what impact balance confidence, sleep, activity levels or cognitive ability impact on a person's ability to multi-task when performing complex walking tasks that reflect the complexity of mobilising in real-life situations.

The proposed study aims to investigate, in healthy adults aged between 18-80 years old, a) the effect of combining functional gait tasks with different types of dual-tasks and cognitive task categories on total Functional Gait Assessment (FGA) score (primary task), and task prioritisation; b) the relationship between FGA single and dual task performance, age, sleep and PA levels; c) the relationship between age, balance confidence, psychological symptoms and sleep with functional gait single and dual task performance, cognitive function, quality of life and PA levels.

Principle Research Questions:

* What is the effect of dual-task type and/or cognitive task category on FGA performance (primary task), gait speed and task prioritisation?
* What is the relationship between age, balance confidence, psychological symptoms, quality of life and sleep with FGA single and dual task performance, cognitive function and PA levels in healthy adults?

Hypothesis:

1. Cognitive dual tasks will affect performance of the primary FGA task, gait speed and task prioritisation more than an auditory dual task.
2. A more sedentary lifestyle, increasing age, poorer sleep state, balance confidence and/or lower (i.e. poorer performance) cognitive function test scores will affect performance on FGA dual task performance.

Eligibility criteria: Inclusion Criteria:

* community-dwelling healthy adults
* aged 18-80 years old
* independently mobile.

Exclusion Criteria:

* Individuals have a central nervous system disorder vestibular disorder and/or acute orthopaedic/musculoskeletal disorder affecting balance control and/or gait
* individuals with lack of a good grasp of written and spoken English language.

Primary outcomes:
measure: Functional Gait Assessment
timeFrame: 5 minutes
Secondary outcomes:
measure: Functional Gait Dual-Task Test
timeFrame: 30 minutes
measure: Mini-Balance Evaluation Systems Test
timeFrame: 5 minutes
measure: Cambridge Neuropsychological Test Automated Battery
timeFrame: 45 minutes
measure: Standard pure tone audiometry
timeFrame: 10 minutes
measure: Speech in Babble Test
timeFrame: 10 minutes
measure: Axivity Wrist Band 3-Axis logging accelerometer
timeFrame: 7 days
measure: Activity-specific Balance Confidence Scale
timeFrame: 3 minutes
measure: Hospital Anxiety and Depression Scale
timeFrame: 3 minutes
measure: Pittsburgh Sleep Quality Index
timeFrame: 3 minutes
measure: Epworth Sleepiness Scale
timeFrame: 3 minutes
measure: EQ-5D-5L
timeFrame: 3 minutes
measure: Situational Vertigo Questionnaire
timeFrame: 3 minutes
measure: Dizziness Handicap Inventory
timeFrame: 3 minutes
measure: Cognitive and Behavioural Symptom Questionnaire
timeFrame: 3 minutes
Other outcomes:
Locations:
city: London
country: United Kingdom
facility: Centre for Human and Applied Physiological Sciences, King's College London
Study officials:
affiliation: King's College London
name: Viktoria Azoidou
role: PRINCIPAL_INVESTIGATOR
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