Clinical trial NCT03545841: HIT in People With Type 1 Diabetes
Official title: High-Intensity Interval Training Improves Aerobic Capacity and Abolishes the Decline in Blood Glucose Observed During Moderate-Intensity Continuous Training Sessions in People With Type 1 Diabetes
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Type1diabetes
Lead sponsor: Liverpool John Moores University
Sponsor class: OTHER
First posted: 2018-06-04
Enrollment: 14
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NON_RANDOMIZED
Intervention model: PARALLEL
Primary purpose: BASIC_SCIENCE

Brief summary: Few people with type 1 diabetes achieve exercise guidelines and many programmes designed to increase physical activity have failed. High-intensity interval training (HIT) has been shown to be a time-efficient alternative to traditional moderate-intensity continuous training (MICT) in various groups without type 1 diabetes. A single bout of HIT does not increase the risk of hypoglycaemia in people with type 1 diabetes. This study aimed to assess whether HIT a safe, effective and time-efficient training strategy to improve cardio-metabolic health and reduce the risk of hypoglycaemia in people with type 1 diabetes.

Detailed description: This study aimed to investigate whether 1) six weeks of high-intensity interval training (HIT) induces similar improvements in cardio-metabolic health markers as moderate-intensity continuous training (MICT) in people with type 1 diabetes, and 2) whether HIT abolishes acute reductions in plasma glucose observed following MICT sessions. Fourteen sedentary individuals with type 1 diabetes (n=7 per group) completed six weeks of HIT or MICT 3 times per week. Pre- and post-training measurements were made of 24h interstitial glucose profiles (using continuous glucose monitors (CGMS)) and cardio-metabolic health markers (V ̇O2peak, blood lipid profile and aortic pulse wave velocity; aPWV). Capillary blood glucose concentrations were assessed before and after exercise sessions throughout the training programme to investigate changes in blood glucose during exercise in the fed state.

Eligibility criteria: Inclusion Criteria:

* duration of type 1 diabetes \>6 months
* basal bolus regimen
* no significant history of hyper- or hypoglycaemia (determined from medical history)

Exclusion Criteria:

duration of type 1 diabetes \<6 months,

* insulin pump therapy
* significant history of hyper- or hypoglycaemia (determined from medical history)
* obesity (BMI \>30 kg∙m-2)
* pregnancy or planning pregnancy
* uncontrolled hypertension (\>180/100 mmHg)
* angina, autonomic neuropathy
* taking any medication that affects heart rate
* major surgery planned within 6 weeks of the study
* severe nonproliferative
* unstable proliferative retinopathy

Primary outcomes:
measure: Maximal aerobic capacity
timeFrame: change in baseline maximal aerobic capacity at 6 weeks
Secondary outcomes:
measure: Vascular stiffness
timeFrame: change in baseline vascular stiffness at 6 weeks
Other outcomes:
Locations:
city: Liverpool
country: United Kingdom
facility: Liverpool John Moores University
state: Merseyside
Study officials:
References: