Clinical trial NCT05217277: Clinical and Biochemical Evaluation of Dental and Periodontal Conditions in Children With Juvenile Idiopathic Arthritis
Official title: Clinical and Biochemical Evaluation of Dental and Periodontal Conditions in Children With Juvenile Idiopathic Arthritis
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Juvenile Idiopathic Arthritis
Gingivitis
Decay, Dental
Keywords: pediatric dentistry
periodontal status
juvenile idiopathic arthritis
Lead sponsor: Marmara University
Sponsor class: OTHER
First posted: 2022-02-01
Enrollment: 114
Sex: ALL
Minimum age (years): 5
Maximum age (years): 16
Standard ages: CHILD
Accepts healthy volunteers: yes
Observational model: CASE_CONTROL
Time perspective: CROSS_SECTIONAL
Sampling method: PROBABILITY_SAMPLE
Study population: Patients who have no disease other than juvenile idiopathic arthritis, newly diagnosed and not yet using medication.

Brief summary: Aimed to be done in the planned thesis to evaluate the dental and periodontal health of patients with newly diagnosed JIA and healthy-periodontal problems with cytokines from saliva and oxidative stress markers non-invasively, and thus, to determine the markers' evaluability in terms of markers in determining the state of inflammation among individuals with and without the disease.

Detailed description: Periodontal diseases and inflammatory diseases such as arthritis show similar clinical pathologies such as connective tissue deterioration and bone destruction. They carry the risk of being seen together and the possibility of mutual influence. It is important whether these patients have a difference in cytokine profile from individuals who do not have the disease. In the literature, it has been determined that pro and anti-inflammatory cytokines, which are involved in the pathogenesis of periodontitis, are also involved in the pathogenesis of juvenile idiopathic arthritis (JIA). Cytokines play an undeniable role in the pathogenesis of both diseases. The cytokine profile in periodontal disease is distinctly similar to that of rheumatoid arthritis (RA). As in RA, the level of pro-inflammatory cytokines such as interleukin-1 beta (IL-1β) and tumor necrosis factor-alpha (TNF-α) increase in periodontal disease. Again, it is stated that oxidative stress assessment is an important factor in evaluating the development of the disease. Saliva evaluation can be made with new oxidative stress markers that can be used in this sense.

On the subject of the proposed thesis; It is to determine the profile of dental and periodontal health in a specific group in terms of biochemical and microbiology using different body fluids together with clinical findings and has an interdisciplinary character. Aimed to be done in the planned thesis;

It was aimed to evaluate the dental and periodontal health of patients with newly diagnosed JIA and healthy-periodontal problems with cytokines from saliva and oxidative stress markers non-invasively, and thus, to determine the markers' evaluability in terms of markers in determining the state of inflammation among individuals with and without the disease.

Eligibility criteria: Inclusion Criteria:

* healty patients

Exclusion Criteria:

* used antibiotics within the last 3 months

Primary outcomes:
measure: biochemical evaluation of saliva in juvenile idiopathic arthritis
timeFrame: baseline
Secondary outcomes:
measure: Evaluation of oral hygiene in patients with juvenile idiopathic arthritis
timeFrame: baseline
measure: Evaluation of periodontal health in patients with juvenile idiopathic arthritis
timeFrame: baseline
measure: Examination of periodontal health in patients with juvenile idiopathic arthritis
timeFrame: baseline
measure: periodontal health in patients with juvenile idiopathic arthritis
timeFrame: baseline
Other outcomes:
Locations:
city: Istanbul
country: Turkey
facility: Marmara University Faculty of Dentistry
state: Maltepe
Study officials:
affiliation: researcher
name: Betul Sozeri
role: STUDY_CHAIR
affiliation: researcher
name: Ferhat Demir
role: STUDY_CHAIR
affiliation: researcher
name: Selin Yıldırım
role: STUDY_CHAIR
References: