louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT03737513: Exercise-induced Collective Rhabdomyolysis
Official title: Exercise-induced Collective Rhabdomyolysis
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Rhabdomyolysis
Keywords: Rhabdomyolysis
Military Training
Lead sponsor: The First Affiliated Hospital, Guangzhou University of Traditional Chinese Medicine
Sponsor class: OTHER
Collaborators: name: Yueqing Hospital Affiliated to Wenzhou Medical University
First posted: 2018-11-09
Enrollment: 35
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: CASE_ONLY
Time perspective: RETROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Students who participated in this military training from the same school

Brief summary: Rhabdomyolysis, which is a characteristic occurrence in associated with muscle cell necrosis, develops due to various causes.The investigators herein report a rare case of collective rhabdomyolysis after high intensity resistance training, including 35 teenagers（participants），in which markedly elevated levels of serum creatine kinase (CK) and serum myoglobin were observed. This high intensity resistance trainings is a part of Military Training(MT)，which all the middle school students must finish before admission。


Eligibility criteria: Inclusion Criteria:

* Clinical diagnosis of rhabdomyolysis;
* Caused by military training;
* Informed consent；
* Must be able to cooperate with blood test.

Exclusion Criteria:

* Caused by drugs and other reasons;
* No hospitalization event

Primary outcomes:
measure: serum creatine kinase；
timeFrame: 3 months
measure: serum myoglobin
timeFrame: 1 week
Secondary outcomes:
Other outcomes:
Locations:
city: Yueqing
country: China
facility: Yueqing Hospital Affiliated to Wenzhou Medical University
state: Zhejiang
Study officials:
References:
Clinical trial NCT03958513: To Evaluate the Effect of Wound Infiltration With Bupivacaine for Post-operative Pain Relief After Laparoscopic Cholecystectomy
Official title: Randomized, Double- Blind, Controlled Trial to Evaluate the Effect of Wound Infiltration With Bupivacaine for Post-operative Pain Relief After Laparoscopic Cholecystectomy
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE2
Conditions: Post-operative Pain
Lead sponsor: Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh
Sponsor class: OTHER
First posted: 2019-05-22
Enrollment: 58
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: To evaluate the effect of wound infiltration with 0.25% Bupivacaine in laparoscopic cholecystectomy in terms of pain severity, patient satisfaction level, quality of life, hospital stay and return to job and normal activities.


Eligibility criteria: Inclusion criteria

* Patients scheduled to undergo laparoscopic cholecystectomy under general anesthesia at department of surgery and department of hepatobiliary system, BSMMU
* Patients who are eligible according to ASA Ⅰ -Ⅱ
* Female or male, age ≥18 years
* Patients who are scheduled for same anesthetic technique and surgical procedure for laparoscopic cholecystectomy
* Discharge of patient between 12 hour to 36 hour after performing procedure
* Patients given consent for enrollment in study

Exclusion criteria

* Patients known to be allergic to certain recommended drugs
* If patients have history of psychiatric illness
* Patients on chronic analgesic therapy for any other indication
* Patients who are scheduled for different anesthetic technique and surgical procedure for laparoscopic cholecystectomy
* Duration of surgery more than 1 hour
* Patients undergoing laparoscopic cholecystectomy for complex gallbladder disease such as incidental gallbladder pancreatitis, gallstone pancreatitis, cholecystoduodenal fistula, mirizzi syndrome
* Special population group such as children, pregnant woman, patients with cirrhosis, diabetics
* Duration of operative procedure more than 1 hour

Primary outcomes:
measure: Post-operative pain: VAS
timeFrame: 12 hours
measure: Post-operative pain: rating scale
timeFrame: 12 HOURS
Secondary outcomes:
measure: Patient Satisfaction Level: questionnaire
timeFrame: 24 hour
measure: Hospital stay
timeFrame: 3-5 days
measure: Pain during hospital discharge: VAS
timeFrame: 3-5days
measure: Time taken to return to job and normal activities
timeFrame: 15-30 days
measure: Assesment of quality of life: index
timeFrame: 15th and 30th post-operative day
Other outcomes:
Locations:
city: Dhaka
country: Bangladesh
facility: Bangabandhu Sheikh Mujib Medical University
Study officials:
References:
Clinical trial NCT01032213: Effect of Magnesium Sulphate on Coagulation
Official title: Effect of Magnesium Sulphate on Postoperative Coagulation as Measured by Thromboelastography
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Myoma
Lead sponsor: Seoul National University Bundang Hospital
Sponsor class: OTHER
First posted: 2009-12-15
Enrollment: 40
Sex: FEMALE
Minimum age (years): 20
Maximum age (years): 60
Standard ages: ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: PREVENTION

Brief summary: Arterial and venous thrombotic events are the clinical manifestation of postoperative hypercoagulability. Altered serum magnesium may play a role in the balance of coagulation. In this study, the investigators investigated the effect of magnesium sulphate on the postoperative coagulation change in total intravenous anesthesia (TIVA).


Eligibility criteria: Inclusion Criteria:

* ASA Ⅰ-Ⅱ patients undergoing pelviscopic gynecologic operation under general anesthesia.

Exclusion Criteria:

* Pregnancy
* Previous known hematologic disorder
* Recent medication interfering with hemostasis
* Severe anemia
* Liver disease
* Cardiovascular or respiratory disease

Primary outcomes:
measure: thromboelastography (TEG) analysis
timeFrame: twice
Secondary outcomes:
measure: hemoglobin level
timeFrame: twice
measure: platelet count
timeFrame: twice
measure: international normalized ratio of prothrombin time (INR-PT)
timeFrame: twice
measure: activated partial thromboplastin time (aPTT)
timeFrame: tiwce
measure: serum magnesium level
timeFrame: twice
Other outcomes:
Locations:
city: Seongnam-si
country: Korea, Republic of
facility: Seoul National University Bundang Hospital
state: Gyeonggi-do
Study officials:
References:
Clinical trial NCT05327413: Femoral External Rotation Measured on CT and MRI
Official title: A Prospective Cohort Study to Compare the Accuracy of Femoral External Rotation Measured on CT and MRI
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Knee Osteoarthritis
Lead sponsor: The Affiliated Hospital of Qingdao University
Sponsor class: OTHER
First posted: 2022-04-14
Enrollment: 100
Sex: ALL
Minimum age (years): 50
Maximum age (years): 85
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: Patients underwent TKA due to knee arthroplasty (Kellgren-Lawrence Grade III or IV)

Brief summary: This study aims to compare the femoral external rotation measured on CT and MRI to that measured intraoperatively to clarify the influence of residual cartilage on posterior condyle on the preoperative planning of total knee arthroplasty.


Eligibility criteria: Inclusion Criteria:

1. 50-85 years old
2. patients with osteoarthritis (Kellgren-Lawrence Grade III or IV) underwent total knee arthroplasty.

Exclusion Criteria:

1. patients cannot endure TKA due to severe heart failure, arrhythmia, myocardial infarction, infection or other reason.
2. patients who cannot undergo MRI.

Primary outcomes:
measure: Femoral external rotation on CT
timeFrame: Preoperative
measure: Femoral external rotation on MRI
timeFrame: Preoperative
measure: Intraoperative femoral external rotation
timeFrame: Intraoperative
Secondary outcomes:
Other outcomes:
Locations:
city: Qingdao
country: China
facility: The affiliated hospital of Qingdao University
state: Shandong
Study officials:
affiliation: The Affiliated Hospital of Qingdao University
name: Shuai Xiang
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT04240613: Tension-free Vaginal Tape Obturator for the Treatment of Urinary Incontinence -Long-term Follow-up
Official title: Tension-free Vaginal Tape Obturator for the Treatment of Urinary Incontinence - Efficacy and Patient Satisfaction in Long-term Follow-up
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Urinary Incontinence,Stress
Urinary Incontinence, Urge
Keywords: TVT-O
long-term follow-up
retrospective
Lead sponsor: Turku University Hospital
Sponsor class: OTHER_GOV
First posted: 2020-01-27
Enrollment: 106
Sex: FEMALE
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: TREATMENT

Brief summary: The efficacy of TVT-O (tension-free vaginal tape obturator) is well established in patients with stress urinary incontinence (SUI). The objective of this study was to evaluate the efficacy, safety and patient satisfaction of TVT-O in patients suffering from primary, mixed (MUI) or recurrent urinary incontinence (UI) in long-term follow-up.

Detailed description: The long-term results after TVT-O have been scarce. At five years no significant differences were seen between TVT (tension-free vaginal tape) and TVT-O for female SUI in a randomized trial. In two studies the patients were followed-up for ten years after the TVT-O procedure. The first randomized study reporting long term outcomes of TVT-O and outside-in TOT (transobturator tape) in women with urodynamic mixed urinary incontinence (MUI) showed that transobturator tension-free vaginal tapes are associated with a good and sustained patient-reported success rate.

The success of the incontinence procedures should be assessed not only with objective measures but also with methods evaluating subjective satisfaction. The aim of this study was to evaluate the efficacy, safety and overall patient satisfaction of the TVT-O technique in a long-term follow-up of patients suffering from primary or recurrent SUI or MUI.

Eligibility criteria: Inclusion Criteria:

We included all the patients who underwent the TVT-O operation between August 2004 and October 2011 in our hospital, Turku university hospital Finland.

Exclusion Criteria:

No exclusion criteria were applied.

Primary outcomes:
measure: objective and subjective treatment success
timeFrame: 9.25 years
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
affiliation: Turku University Hospital
name: Eija Laurikainen
role: STUDY_DIRECTOR
References:
Clinical trial NCT00873613: Digital Ocular Fundus Photography in the Emergency Department: A New Application for Telemedicine?
Official title: Digital Ocular Fundus Photography in the Emergency Department: A New Application for Telemedicine?
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Headache
Acute, Focal Neurologic Disease
Severely Elevated Blood Pressure
Acute Visual Loss
Lead sponsor: Emory University
Sponsor class: OTHER
First posted: 2009-04-01
Enrollment: 705
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NON_RANDOMIZED
Intervention model: CROSSOVER
Primary purpose: SCREENING

Brief summary: The purpose of this study is to determine if non-dilated retinal photography in the emergency room improves the diagnosis of papilledema (optic nerve swelling) in patients with neurologic disease compared to direct ophthalmoscopy.


Eligibility criteria: Inclusion Criteria:

* Presenting complaint of headache, acute focal neurologic disease, or acute visual changes
* Diastolic blood pressure \>= 120
* Age 18 or older

Exclusion Criteria:

* Unable to sit-up, not interested in participation, confused
* Age 17 or younger

Primary outcomes:
measure: Difference in detection rate of papilledema by emergency department physicians using non-dilated retinal photography vs. direct ophthalmoscopy.
timeFrame: 6-12 months
Secondary outcomes:
Other outcomes:
Locations:
city: Atlanta
country: United States
facility: Emory University
state: Georgia
Study officials:
References:
citation: Bruce BB, Lamirel C, Wright DW, Ward A, Heilpern KL, Biousse V, Newman NJ. Nonmydriatic ocular fundus photography in the emergency department. N Engl J Med. 2011 Jan 27;364(4):387-9. doi: 10.1056/NEJMc1009733. No abstract available.
citation: Bruce BB, Lamirel C, Biousse V, Ward A, Heilpern KL, Newman NJ, Wright DW. Feasibility of nonmydriatic ocular fundus photography in the emergency department: Phase I of the FOTO-ED study. Acad Emerg Med. 2011 Sep;18(9):928-33. doi: 10.1111/j.1553-2712.2011.01147.x.
citation: Bruce BB, Thulasi P, Fraser CL, Keadey MT, Ward A, Heilpern KL, Wright DW, Newman NJ, Biousse V. Diagnostic accuracy and use of nonmydriatic ocular fundus photography by emergency physicians: phase II of the FOTO-ED study. Ann Emerg Med. 2013 Jul;62(1):28-33.e1. doi: 10.1016/j.annemergmed.2013.01.010. Epub 2013 Feb 21.
Clinical trial NCT05050513: Evaluation of HEMO2Life® for Kidney Graft Preservation (OXYOP): 4 Years Follow-up
Official title: Evaluation of a Marine OXYgen Carrier (HEMO2Life®) for hypOthermic Kidney Graft Preservation Before Transplantation (OXYOP): 4 Years Follow-up
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Transplant; Complication, Failure
Keywords: renal transplantation
organ preservation
oxygen carrier
Lead sponsor: University Hospital, Brest
Sponsor class: OTHER
First posted: 2021-09-20
Enrollment: 116
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: CASE_CONTROL
Time perspective: RETROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: 116 patients previously included in the oxyop study

Brief summary: 4 years follow-up of the oxyop study.

Detailed description: Oxyop (NCT02652520 PHRC) was a safety study evaluating the use of an oxygen carrier HEMO2life® as an additive in organ preservation solution in 60 transplanted kidneys. This was a national multicenter (6 centers) open-labeled safety study on HEMO2life® that included 58 recipients. The first patient was included on March 24th, 2016 and the study was completed on February 23th, 2018 (1 year of recruitment and 1 year of follow-up). We also analyzed some efficacy secondary end points using a paired analysis (local kidney receiving HEMO2life® versus contralateral kidney transplanted elsewhere in France). Oxyop4 aims to analyse 4 years results.

Eligibility criteria: Inclusion Criteria:

* informed patients participating to the oxyop study

Exclusion Criteria:

* patients refusing to participate

Primary outcomes:
measure: eGFR
timeFrame: 4 years
Secondary outcomes:
measure: patient survival
timeFrame: 4 years
measure: graft survival
timeFrame: 4 years
measure: rejection rate
timeFrame: 4 years
measure: infection rate
timeFrame: 4 years
measure: hospitalization
timeFrame: 4 years
Other outcomes:
Locations:
city: Brest
country: France
facility: CHU de Brest
Study officials:
affiliation: University hospital Brest France
name: Yannick le Meur
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT00767013: Preoperative Assessment of Aortic Valve Stenosis and Coronary Artery Disease
Official title: Preoperative Assessment of Aortic Valve Stenosis and Coronary Artery Disease: Dual-source Computed Tomography Compared With Invasive Coronary Angiography and Transthoracic Echocardiography
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Aortic Valve Stenosis
Coronary Disease
Keywords: DSCT, coronary artery disease, aortic valve stenosis
Lead sponsor: Luzerner Kantonsspital
Sponsor class: OTHER
First posted: 2008-10-06
Enrollment: 65
Sex: ALL
Minimum age (years): 40
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: DIAGNOSTIC

Brief summary: We sought to determine whether the dual-source computed tomography assessment of aortic valve stenosis and coronary artery disease is equivalent to or even better than conventional invasive coronary angiography and transthoracic echocardiography.

Detailed description: Until now invasive coronary angiography has established itself for the assessment of symptomatic aortic valve stenosis. Literature shows a good correlation between MSCT, MRI, TTE and TEE for evaluating the severity of the aortic valve stenosis.

The dual-source computed tomography (DSCT) is capable of assessing coronary arteries with a high sensitivity and specificity in term of relevant stenosis (\>50%), due to its excellent spatial and temporal resolution. This study includes the assessment of patients with symptomatic valve stenosis. The severity of the aortic valve stenosis is being assessed by DSCT and TTE. Significant coronary artery stenosis and its localisation are assessed by DSCT and invasive coronary angiography. We examine the correlation between DSCT on one side and either TTE or invasive coronary angiography on the other.

Eligibility criteria: Inclusion Criteria:

* Patients with aortic valve disease who were scheduled to undergo cardiac surgery

Exclusion Criteria:

* Hemodynamic instability
* Renal insufficiency (serum creatinine level \> 133umol/L)
* Known allergy to iodinated contrast agents
* Non-treated hyperthyreosis

Primary outcomes:
measure: Quality of cardiac imaging in computed tomography
timeFrame: After comparison of imaging measurements
Secondary outcomes:
Other outcomes:
Locations:
city: Lucerne
country: Switzerland
facility: Luzerner Kantonsspital, Department of Cardiology
state: Luzern
Study officials:
affiliation: Luzerner Kantonsspital
name: Paul Erne, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT01566513: Effectiveness and Cost Effectiveness of Peer Mentors in Reducing Hospital Use
Official title: Effectiveness and Cost Effectiveness of Peer Mentors in Reducing Hospital Use
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Serious Mental Illness
Keywords: Peer Support
Cost Effectiveness
Reducing Hospital use
Serious Mental Illness
Lead sponsor: Yale University
Sponsor class: OTHER
Collaborators: name: National Institute of Mental Health (NIMH)
First posted: 2012-03-29
Enrollment: 285
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The current study, through a randomized controlled design, will evaluate the effectiveness of peer support, as compared to usual care and to an equivalent amount of support offered by peer case managers and non-peer recovery mentors, in reducing hospital days and readmissions and in promoting recovery and community inclusion among adults with mental illnesses with histories of multiple hospitalizations. The current study evaluates the cost-effectiveness of adding peer support to the array of services available to persons with serious mental illnesses who have histories of multiple hospitalizations and will test a theoretical model of the active ingredients of peer support, focusing specifically on the roles of 1) instillation of hope through positive self-disclosure; 2) role modeling of self-care and exploring new ways of using experiential knowledge; and 3) a trusting relationship characterized by acceptance, understanding, and empathy with conditional regard.


Eligibility criteria: Inclusion Criteria:

* 2 or more psychiatric hospitalizations in the past year
* A diagnosis of serious mental illness

Exclusion Criteria:

* Dementia or other organic condition limiting ability to provide informed consent

Primary outcomes:
measure: Service use
timeFrame: 3 months
measure: Service Use
timeFrame: 9 months
Secondary outcomes:
measure: Psychiatric symptoms
timeFrame: 3 months
measure: Quality of life
timeFrame: 3 month
measure: Community inclusion
timeFrame: 3 months
measure: Psychiatric symptoms
timeFrame: 9 months
measure: Quality of Life
timeFrame: 9 months
measure: Community Inclusion
timeFrame: 9 months
Other outcomes:
Locations:
city: New Haven
country: United States
facility: Yale Psychiatric Hospital
state: Connecticut
Study officials:
affiliation: Yale Program for Recovery and Community Health
name: Larry Davidson, PhD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT02970513: Psychological Evaluation According Colonic Colonization by Escherichia Coli of Patients After Colorectal Surgery
Official title: Psychological Evaluation According Colonic Colonization by Escherichia Coli of Patients After Colorectal Surgery
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Colorectal Cancer
Keywords: Escherichia coli
Microbiota
Colorectal cancer
Psychiatric disorders
Personality traits
Lead sponsor: University Hospital, Clermont-Ferrand
Sponsor class: OTHER
First posted: 2016-11-22
Enrollment: 12
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: SCREENING

Brief summary: The purpose of this study is to determine whether the presence of pathogenic Escherichia coli in colon is associated with psychiatric disorders.

Detailed description: Colonic colonization by pathogenic Escherichia coli was determined when patients were operated on for colorectal cancer.

Several years later, the investigator investigate past and actual psychiatric disorder using the Mini International Neuropsychiatric Interview (MINI). Actual depression and anxiety scores are evaluated with Hamilton scales and personality traits are investigated using Personality Inventory for DSM-5 (PID-5).

Anxiety and depression scores, psychiatric diagnoses (MINI) and personality traits were compared in patients according to Escherichia coli presence/absence.

Eligibility criteria: Inclusion Criteria:

* patients operated on for colorectal cancer in the digestive surgery department of Clermont-Ferrand hospital
* patients older than 18 years,
* patients whose Escherichia coli colonization was analyzed after surgery
* patients which are always followed by the digestive surgery department.

Exclusion Criteria:

* Patients with dementia will not be included, according to the MMSE score:
* 22 if no grade
* 23 if study certificate or CAP or college without patent
* 25 if patent or school without the tray
* 26 or more when bin

Primary outcomes:
measure: Hamilton anxiety and depression score comparison
timeFrame: at day 1
Secondary outcomes:
measure: Psychiatric prevalence comparison
timeFrame: at day 1
measure: personality traits comparison
timeFrame: at day 1
Other outcomes:
Locations:
city: Clermont-Ferrand
country: France
facility: CHU Clermont-Ferrand
Study officials:
affiliation: University Hospital, Clermont-Ferrand
name: Isabelle JALENQUES
role: PRINCIPAL_INVESTIGATOR
References: