Clinical trial NCT02577042: Study of the Effect of Atorvastatin for Reducing Aging-related Complication in HIV-infected Patients Older Than 45 Years Receiving a Protease Inhibitor-based Regimen Versus a Raltegravir-based Regimen
Official title: Study of the Effect of Atorvastatin for Reducing "Inflaming" (Aging-related Complication) in HIV-infected Patients Older Than 45 Years Receiving a Protease Inhibitor-based Regimen Versus a Raltegravir-based Regimen
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE4
Conditions: Aging-related Inflammation in HIV-infected Patients
Keywords: Raltegravir
protease inhibitors
darunavir
inflammation
statins
comorbidities
Lead sponsor: Fundación FLS de Lucha Contra el Sida, las Enfermedades Infecciosas y la Promoción de la Salud y la Ciencia
Sponsor class: OTHER
First posted: 2015-10-16
Enrollment: 42
Sex: ALL
Minimum age (years): 60
Maximum age (years): 99
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: Physicians in charge of HIV-infected patients are increasingly being faced to previously unrecognized comorbid conditions such as atherosclerosis and cardiovascular events, loss of renal function, osteopenia/osteoporosis and bone fractures or non-AIDS-defining cancers (1-4). The incidence of these conditions seems to be higher than in the general population but there are controversial data about if these diseases appear at a younger age in HIV-infected patients.

The investigators propose a strategy for treatment of elderly HIV-infected patients with a double impact on systemic inflammation and age-related co-morbidities by switching the protease inhibitors by raltegravir, a integrase inhibitor with a neutral effect on lipid and bone metabolism, and adding an statin because of their anti-inflammatory effect. For safety reasons, only patients with maintained viral suppression (documented indetectable viral load for 1 year or more), and no history of virological failure to integrase inhibitors or suspected or documented resistance mutations to the integrase or retrotranscriptase will be candidates for the study.

Interleukin -6 and D-dimer are biomarkers that most strongly predict mortality in treated HIV infection and sCD14, sCD163 are soluble markers of monocyte activation that reflect a key source of inflammation and coagulation in HIV infection and predict mortality (26,27). For that reasons, these markers were chosen to determine changes on them after the introduction of the statin and the change of antiretrovirals

Detailed description: Physicians in charge of HIV-infected patients are increasingly being faced to previously unrecognized comorbid conditions such as atherosclerosis and cardiovascular events, loss of renal function, osteopenia/osteoporosis and bone fractures or non-AIDS-defining cancers (1-4).

The incidence of these conditions seems to be higher than in the general population but there are controversial data about if these diseases appear at a younger age in HIV-infected patients.

Different pathogenic mechanisms are involved in the increased risk of comorbidities. First, the increased life expectancy of the HIV-infected population. The number of elderly HIV+ individuals is dramatically increasing, and nowadays, approximately one-half of the people living with HIV in the United States are age 50 or older (5). In this sense, aging itself is a condition associated with a chronic inflammation and immune senescence, contributing to accelerate age-related morbidity. Second, the persistent inflammatory state and activation of the immune system also induced by the HIV-infection, per se. This condition amplifies the risk of age-related morbidity (6-9). Finally, antiretroviral-related toxicities contribute to accelerate the apparition of some of these diseases such as the dyslipidemia and cardiovascular events (mainly associated with the protease inhibitors use), renal damage or low bone mineral density (especially by tenofovir and probably also by protease inhibitors).

As a consequence, one of the current aims of HIV management is the management of chronic non-infectious co-morbidities in an increasingly older and more complex population. The use of the newest and more safety antiretroviral drugs is a mandatory strategy, especially in this elderly population, to achieve a maintained viral suppression. However, there are many published studies showing higher levels of inflammation even in patients under a viral suppression, in comparison with general population. Regarding this condition, the investigators currently lack effective interventions to potently block this inflammatory status. Although some initial data are published about this regard, data in elderly HIV-infected people are lacking.

Based on these data, the investigators propose a strategy for treatment of elderly HIV-infected patients with a double impact on systemic inflammation and age-related co-morbidities by switching the protease inhibitors by raltegravir, a integrase inhibitor with a neutral effect on lipid and bone metabolism, and adding an statin because of their anti-inflammatory effect. For safety reasons, only patients with maintained viral suppression (documented indetectable viral load for 1 year or more), and no history of virological failure to integrase inhibitors or suspected or documented resistance mutations to the integrase or retrotranscription will be candidates for the study.

Raltegravir is an antiretroviral drug that received approval by the U.S. Food and Drug Administration (FDA) in 2007. It was the first of a new class of HIV drugs, the integrase inhibitors, and exhibited rapid, potent and durable antiretroviral activity in antiretroviral naïve patients and in treatment-experienced patients with drug-resistant HIV-1 (10-12). Raltegravir has demonstrated a neutral effect on lipid and renal parameters, and a better impact on bone mineral density (13) and lipid profile than protease inhibitors (14).

Statins are lipid-lowering drugs that also exert anti-inflammatory effects, and have immune-modulatory properties. Recent studies in HIV-infected population have suggested that statins have an anti-inflammatory effect, evaluated by inflammatory markers (15-21), and that the statin use is associated with a lower risk of non-AIDS defining morbidities and malignancies and mortality (22-25). But limited data have been published, mainly based on retrospective studies, and no clinical recommendations are available. The investigators propose the use of atorvastatin to study the anti-inflammatory effect measuring changes in inflammatory markers and some clinical conditions. Atorvastatin was chosen due to the low drug-drug interactions of this statin and ritonavir and the low cost. Since very few data are available about the effect of statins on inflammatory markers and clinical conditions, a intermediate dose (20 mg per day) was selected.

IL-6 and D-dimer are biomarkers that most strongly predict mortality in treated HIV infection and sCD14, sCD163 are soluble markers of monocyte activation that reflect a key source of inflammation and coagulation in HIV infection and predict mortality (26,27). For that reasons, these markers were chosen to determine changes on them after the introduction of the statin and the change of antiretrovirals.

Eligibility criteria: Inclusion Criteria:

* Patient having a diagnosis of HIV-1 infection.
* Age 45 years old.
* Current highly active antiretroviral therapy including Truvada or Kivexa plus a ritonavir boosted PI started at least 3 months before.
* Maintained undetectable plasma HIV-1 RNA (VL \< 50 copies/mL) for at least 12 months.
* Voluntary written informed consent.

Exclusion Criteria:

* History of virological failure to integrase inhibitors.
* Suspected or documented resistance mutations to the integrase, as well as NRTI-related mutations that may impact nucleoside activity in current regimen.
* Systemic concurrent process such as coinfection with hepatitis C or B, acute systemic infection within the last 4 months, neoplasm, chronic inflammatory process, etc.
* Treatment with other drugs with anti-inflammatory, anticoagulant or antiplatelet effect (for instance corticosteroids, aspirin, etc...)
* Therapy with statins within the last 6 months.

Primary outcomes:
measure: Changes in the Inflammatory Marker IL-6
timeFrame: baseline, wk24 and wk72
measure: Changes in Plasma Soluble Markers (D-dimer)
timeFrame: baseline, wk24 and wk72
Secondary outcomes:
Other outcomes:
measure: Changes in the Inflammatory, Immune and Coagulation
timeFrame: at week 72 from week 24 to assess the effect of statin
measure: Compare Intergroup and Intragroup Changes in the Inflammatory, Immune and Coagulation
timeFrame: at week 72 from baseline to assess the effect of PI or raltegravir plus statin
measure: Compare Intergroup and Intragroup Changes in the Inflammatory, Immune and Coagulation
timeFrame: at week 24 from baseline to asses the effect of PI or raltegravir
measure: Compare Intergroup and Intragroup Changes in Lipid Profile
timeFrame: at week 72 from week 24 to assess the effect of statin
measure: Compare Intergroup and Intragroup Changes in Lipid Profile
timeFrame: at week 72 from baseline to assess the effect of PI or raltegravir plus statin
measure: Compare Intergroup and Intragroup Changes in Lipid Profile
timeFrame: at week 24 from baseline to asses the effect of PI or raltegravir
measure: Compare Intergroup and Intragroup Changes in Lumbar and Femoral BMD and T-score Measured by DEXA
timeFrame: at week 72 from week 24 to assess the effect of statin
measure: Compare Intergroup and Intragroup Changes in Lumbar and Femoral BMD and T-score Measured by DEXA
timeFrame: at week 72 from baseline to assess the effect of PI or raltegravir plus statin
measure: Compare Intergroup and Intragroup Changes in Lumbar and Femoral BMD and T-score Measured by DEXA
timeFrame: at week 24 from baseline to asses the effect of PI or raltegravir
measure: Compare Intergroup and Intragroup Changes in Bone Turnover Markers
timeFrame: at week 72 from week 24 to assess the effect of statin
measure: Compare Intergroup and Intragroup Changes in Bone Turnover Markers
timeFrame: at week 72 from baseline to assess the effect of PI or raltegravir plus statin
measure: Compare Intergroup and Intragroup Changes in Bone Turnover Markers
timeFrame: at week 24 from baseline to asses the effect of PI or raltegravir
measure: Compare Intergroup and Intragroup Changes in Renal Parameters
timeFrame: at week 72 from week 24 to assess the effect of statin
measure: Compare Intergroup and Intragroup Changes in Renal Parameters
timeFrame: at week 72 from baseline to assess the effect of PI or raltegravir plus statin
measure: Compare Intergroup and Intragroup Changes in Renal Parameters
timeFrame: at week 24 from baseline to asses the effect of PI or raltegravir
measure: Viral Load < 50 Copies
timeFrame: at week 72
measure: Viral Load > 50 Copies
timeFrame: through study completion
measure: CD4+/CD8+ T Lymphocytes
timeFrame: at week 72 from baseline
Locations:
city: Badalona
country: Spain
facility: Germans Trias i Pujol Hospital
state: Barcelona
Study officials:
References:
citation: Negredo E, Jimenez M, Puig J, Loste C, Perez-Alvarez N, Urrea V, Echeverria P, Bonjoch A, Clotet B, Blanco J. A randomized pilot trial to evaluate the benefit of the concomitant use of atorvastatin and Raltegravir on immunological markers in protease-inhibitor-treated subjects living with HIV. PLoS One. 2020 Sep 17;15(9):e0238575. doi: 10.1371/journal.pone.0238575. eCollection 2020.
citation: Negredo E, Estrada V, Domingo P, Gutierrez MD, Mateo GM, Puig J, Bonjoch A, Ornelas A, Echeverria P, Estany C, Toro J, Clotet B. Switching from a ritonavir-boosted PI to dolutegravir as an alternative strategy in virologically suppressed HIV-infected individuals. J Antimicrob Chemother. 2017 Mar 1;72(3):844-849. doi: 10.1093/jac/dkw504.