Clinical trial NCT04871906: The Effect of Stretching Exercises on Vascular Function, Blood Flow, and Walking Function in Middle and Older Adults
Official title: The Effect of Stretching Exercises on Vascular Function, Blood Flow, and Walking Function in Middle and Older Adults
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Stretch
Keywords: stretching exercise
vascular function
blood flow
walking function
fitness
Lead sponsor: National Yang Ming Chiao Tung University
Sponsor class: OTHER
First posted: 2021-05-04
Enrollment: 48
Sex: ALL
Minimum age (years): 20
Maximum age (years): 85
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: HEALTH_SERVICES_RESEARCH

Brief summary: This study examines the relationship between circulation and walking speed after performing 8-week stretching exercises.

Detailed description: This study examines the relationship between circulations and walking speeds. Most studies in the field of stretching exercises have only focused on improvements of endothelial functions in younger population; however, I aim to emphasize its effects on different populations, such as people with frailty, low physical activity level, weakness and postoperative status. Previous research has established that stretching exercises can improve walking function by modulations of musculoskeletal or neuromuscular system. The importance and originality of this study are that it explores the relationship between circulation and walking speed. Due to the inability to extrapolate outcomes; short-term effect of improved blood vessel function; the unclear mechanism of stretching exercises; and considering the different physical fitness groups, I design a home-based, low-dose, and anatomic chain-based stretching exercises to verify the possible mechanism and effects.

Eligibility criteria: Inclusion Criteria:

1. age between 20-85 years old
2. Follow instructions
3. Walk with/without assistive technology

Exclusion Criteria:

1. Unstable acute or chronic health conditions
2. Peripheral vascular diseases
3. Non-musculoskeletal problems that would limit stretching exercises
4. Participate in other exercise programs

Primary outcomes:
measure: vascular functions-Stiffness index(1)
timeFrame: pre-intervention(1st week)
measure: vascular functions-Stiffness index(2)
timeFrame: during intervention(4th week)
measure: vascular functions-Stiffness index(3)
timeFrame: post-intervention(8th week)
measure: vascular functions-Reflective index(1)
timeFrame: pre-intervention(1st week)
measure: vascular functions-Reflective index(2)
timeFrame: during intervention(4th week)
measure: vascular functions-Reflective index(3)
timeFrame: post-intervention(8th week)
measure: vascular functions-Vascular age
timeFrame: pre-intervention(1st week)
measure: Ultrasound parameters-peak-systolic velocity(1)
timeFrame: pre-intervention(1st week)
measure: Ultrasound parameters-peak-systolic velocity(2)
timeFrame: during intervention(4th week)
measure: Ultrasound parameters-peak-systolic velocity(3)
timeFrame: post-intervention(8th week)
measure: Ultrasound parameters-end-diastolic velocity(1)
timeFrame: pre-intervention(1st week)
measure: Ultrasound parameters-end-diastolic velocity(2)
timeFrame: during intervention(4th week)
measure: Ultrasound parameters-end-diastolic velocity(3)
timeFrame: post-intervention(8th week)
measure: Ultrasound parameters-mean velocity(1)
timeFrame: pre-intervention(1st week)
measure: Ultrasound parameters-mean velocity(2)
timeFrame: during intervention(4th week)
measure: Ultrasound parameters-mean velocity(3)
timeFrame: post-intervention(8th week)
measure: Ultrasound parameters-mean volume flow(1)
timeFrame: pre-intervention(1st week)
measure: Ultrasound parameters-mean volume flow(2)
timeFrame: during intervention(4th week)
measure: Ultrasound parameters-mean volume flow(3)
timeFrame: post-intervention(8th week)
measure: Ultrasound parameters-resistance index(1)
timeFrame: pre-intervention(1st week)
measure: Ultrasound parameters-resistance index(2)
timeFrame: during intervention(4th week)
measure: Ultrasound parameters-resistance index(3)
timeFrame: post-intervention(8th week)
measure: Ultrasound parameters-pulsatility index(1)
timeFrame: pre-intervention(1st week)
measure: Ultrasound parameters-pulsatility index(2)
timeFrame: during intervention(4th week)
measure: Ultrasound parameters-pulsatility index(3)
timeFrame: post-intervention(8th week)
measure: Ultrasound parameters-diameter(1)
timeFrame: pre-intervention(1st week)
measure: Ultrasound parameters-diameter(2)
timeFrame: during intervention(4th week)
measure: Ultrasound parameters-diameter(3)
timeFrame: post-intervention(8th week)
measure: Ultrasound parameters-area(1)
timeFrame: pre-intervention(1st week)
measure: Ultrasound parameters-area(2)
timeFrame: during intervention(4th week)
measure: Ultrasound parameters-area(3)
timeFrame: post-intervention(8th week)
measure: walking speed-preferred(1)
timeFrame: pre-intervention(1st week)
measure: walking speed-preferred(2)
timeFrame: during intervention(4th week)
measure: walking speed-preferred(3)
timeFrame: post-intervention(8th week)
measure: walking speed-fast(1)
timeFrame: pre-intervention(1st week)
measure: walking speed-fast(2)
timeFrame: during intervention(4th week)
measure: walking speed-fast(3)
timeFrame: post-intervention(8th week)
Secondary outcomes:
measure: body composition-height
timeFrame: pre-intervention(1st week)
measure: body composition-weight
timeFrame: pre-intervention(1st week)
measure: body composition-waist circumference
timeFrame: pre-intervention(1st week)
measure: vital sign-blood pressure(1)
timeFrame: pre-intervention(1st week)
measure: vital sign-blood pressure(2)
timeFrame: during intervention(4th week)
measure: vital sign-blood pressure(3)
timeFrame: post-intervention(8th week)
measure: vital sign-heart rate(1)
timeFrame: pre-intervention(1st week)
measure: vital sign-heart rate(2)
timeFrame: during intervention(4th week)
measure: vital sign-heart rate(3)
timeFrame: post-intervention(8th week)
measure: flexibility-chair sit and reach test (1)
timeFrame: pre-intervention(1st week)
measure: flexibility-chair sit and reach test (2)
timeFrame: during intervention(4th week)
measure: flexibility-chair sit and reach test (3)
timeFrame: post-intervention(8th week)
measure: grip strength
timeFrame: pre-intervention(1st week)
measure: cognitive function
timeFrame: pre-intervention(1st week)
measure: frailty
timeFrame: pre-intervention(1st week)
measure: basic data
timeFrame: pre-intervention(1st week)
measure: ACSM-PAR-Q+
timeFrame: pre-intervention(1st week)
measure: IPAQ
timeFrame: pre-intervention(1st week)
measure: fitness
timeFrame: pre-intervention(1st week)
measure: adherence of exercise
timeFrame: post-intervention(8th week)
Other outcomes:
Locations:
city: Taipei
country: Taiwan
facility: National Yang Ming University
Study officials:
affiliation: National Yang Ming Chiao Tung University
name: Liang-Ying Lai
role: PRINCIPAL_INVESTIGATOR
References: