louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT06916000: Assessment of PENG Block as a Part of Multimodal Analgesia Following Hip Surgeries.
Official title: Effect of Ultrasound Guided Pericapsular Nerve Group (PENG) Block on Perioperative Pain Management in Patients Undergoing Hip Arthroplasty
Study type: INTERVENTIONAL
Overall status: ACTIVE_NOT_RECRUITING
Phase: NA
Conditions: Anesthesia
Lead sponsor: Ain Shams University
Sponsor class: OTHER
First posted: 2025-04-08
Enrollment: 50
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: to study the effect of Pericapsular nerve group (PENG) block as a part of multimodal analgesia regimen for hip arthroplasties

Detailed description: PENG block is a novel block described by Giron-Arango in 2018 to anesthesize the anterior hip capsule as it is supplied by branches from femoral, obturator and accessory obturator nerves, sparing motor function is an additional significance So currently the block is used to reduce post operative opioid consumption, delay time rescue analgesia, facilitate positioning for spinal anesthesia for hip surgeries and to accelerate mobility and so hospital discharge saving this vulnerable group of patient from any hospital acquired pneumonia, decreasing hospital stays, and improving recovery times would provide valuable insights into its cost-effectiveness and long-term benefits for healthcare system Our primary outcome to be studied is pain assessment via Numer Rating Scale over 24 hours postoperatively, in addition to to secondary outcomes including the aforementioned advantages.

Eligibility criteria: Inclusion criteria:

* Age group: 18 years and older.
* ASA classification I to III.
* BMI : 18-35 .
* Gender: both sex

Exclusion criteria:

* Patient refusal.
* Patients on long-term pain medications.
* History of allergic reactions to local anesthetics
* Patients who had mental illness or uncooperative patients.
* BMI \> 35 .
* Patients having coagulopathies or on anticoagulant or antiplatelet therapy.
* Severe cardiopulmonary disease
* ASA IV or more
* Diabetic or other neuropathies

Primary outcomes:
measure: Pain score: pain assessment using a Numeric Rating System (NRS) immediately in the postoperative period.
timeFrame: 24 hours
Secondary outcomes:
measure: Rescue analgesia timing and opioid consumption over 24 hours
timeFrame: 24 hours
Other outcomes:
Locations:
city: Abbasia
country: Egypt
facility: Faculty of medicine, Ain Shams University
state: Cairo
Study officials:
References:
Clinical trial NCT02234700: Are Corneal Epithelial Defects Related to Changes in Ocular Bacterial Flora in Patients With ANLDO
Official title: To Estimate Whether Corneal Epithelial Defects Occur in Patients With Acquired Nasolacrimal Duct Obstructions is Linked to Changes Occurring Within Ocular Bacterial Flora in These Patients, and What Are the Specific Changes in Their Flora.
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Acquired Nasolacrimal Duct Obstruction
Lead sponsor: Western Galilee Hospital-Nahariya
Sponsor class: OTHER_GOV
First posted: 2014-09-09
Enrollment: 60
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: CASE_CONTROL
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: 30 patients with nasolacrimal duct obstruction and 30 healthy patients

Brief summary: Comparison between patients with nasolacrimal duct obstruction and healthy patients and the influence of their bacterial flora on the corneal epithelium.

Detailed description: Any patient with nasolacrimal duct obstruction above the age of 18 Comparing changes in their bacterial ocular flora to healthy patients without obstruction and above 18 years of age

Eligibility criteria: Inclusion Criteria:

* 18 years of age or older, nasolacrimal duct obstruction

Exclusion Criteria:

* younger then 18 years of age
* ocular infections
* patients after repair of lacrimal duct surgery
* systemic active diseases
* patients taking medication that are know to influence bacterial flora of the eye

Primary outcomes:
measure: the change of ocular normal flora in patients with nasolacrimal duct obstruction as a comparison to general population.
timeFrame: 6 month
Secondary outcomes:
Other outcomes:
Locations:
city: Naharya
country: Israel
facility: Western Galileeh Hospital
Study officials:
affiliation: Medical Center of the Galilee
name: Yanir Kassif, M.D
role: STUDY_CHAIR
References:
Clinical trial NCT03136900: Impact on the Nitrogen Balance, Autonomy, Safety and Tolerance of Enteral Diets Made of With Nutrilon Without Lactose® Fortified by Concentration Versus by Maltodextrin and Oil Supplementation,After Surgery for Congenital Heart Disease, in Infants.
Official title: Controlled, Randomized, Double-blind, Monocentric Clinical Study Evaluating the Impact on the Nitrogen Balance, Autonomy, Safety and Tolerance of Enteral Diets Made of Nutrilon Without Lactose® Fortified by Concentration Versus by Maltodextrin and Oil Supplementation, After Surgery for Congenital Heart Disease, in Children Aged Zero to Two Years Old
Study type: INTERVENTIONAL
Overall status: TERMINATED
Phase: NA
Conditions: Congenital Heart Disease in Children
Lead sponsor: Queen Fabiola Children's University Hospital
Sponsor class: OTHER
First posted: 2017-05-02
Enrollment: 41
Sex: ALL
Maximum age (years): 2
Standard ages: CHILD
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: SUPPORTIVE_CARE

Brief summary: An adequate nutritional support after a cardiac surgery enhances the morbidity and mortality.

After a cardiac surgery, the energy expenditure is estimated to be around 55 kcal/kg/d. The caloric intake is not the only important nutritional variable in PICU. The protein intake objective is around 1,5g/kg/d in order to reduce muscular catabolism.

The aim of this study is to compare the impact of an isocaloric enteral diet, either fortified by milk concentration (in order to increase the protein intake) or by a supplement of maltodextrin and oil in children from 0 to 2 years, after surgery for congenital heart disease.


Eligibility criteria: Inclusion Criteria:

* Children from 0 to 2 years undergoing cardiac surgery (corrective or palliative) for congenital heart surgery, with or without extracorporeal circulation
* Expected stay of 5 days in PICU after surgery
* Expected need of invasive ventilation for 48h after surgery
* Expected need for enteral feeding during 5 days.
* Obtaining the informed consent of the child's legal guardian after being informed of the goals, benefits and potential risks of this study

Exclusion Criteria:

* Medical indications for specific diet
* ECMO
* Dialysis

Primary outcomes:
measure: positive nitrogen balance
timeFrame: Day 5 post operative
Secondary outcomes:
measure: duration of enteral feeding
timeFrame: up to 120 days post operative
measure: duration of invasive or non-invasive ventilatory support
timeFrame: up to 120 days post operative
measure: length of hospital stay in intensive care unit
timeFrame: up to 120 days post operative
measure: length of hospital stay in hospital
timeFrame: up to 120 days post operative
Other outcomes:
Locations:
city: Brussels
country: Belgium
facility: Hôpital Universitaire Des Enfants Reine Fabiola
Study officials:
References:
Clinical trial NCT03026400: Sub vs Trans-umbilical Incision: A Patient's Satisfaction-centered Trial
Official title: Sub vs Trans-umbilical Incision: A Patient's Satisfaction-centered Randomised Trial
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Patient Satisfaction
Surgical Wound
Incision
General Surgery
Lead sponsor: Université de Sherbrooke
Sponsor class: OTHER
First posted: 2017-01-20
Enrollment: 54
Sex: ALL
Minimum age (years): 18
Maximum age (years): 70
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: OTHER

Brief summary: While some studies have suggested that subumbilical and transumbilical incisions have a similar clinical efficiency and safety, no study has yet evaluated their respective impact on patient's postoperative aesthetic satisfaction.

The objective of this randomised trial is to compare patient's postoperative aesthetic satisfaction depending on the type of incision which is performed during surgeries.


Eligibility criteria: Inclusion Criteria:

* Patients 18-70 years old having a planned laparoscopic surgery with an umbilical first trocar at CHUS were included.

Exclusion Criteria:

* Patients with a BMI \> 40 or that had previous abdominal surgeries involving the umbilicus were excluded.

Primary outcomes:
measure: Change in postoperative patient's aesthetic satisfaction
timeFrame: 6 months
Secondary outcomes:
measure: Level of patient's awareness regarding the aesthetic appearance of the umbilicus
timeFrame: Pre-operative
Other outcomes:
Locations:
city: Sherbrooke
country: Canada
facility: Centre Hospitalier Universitaire de Sherbrooke
state: Quebec
Study officials:
affiliation: Centre de recherche du Centre hospitalier universitaire de Sherbrooke
name: Nathalie McFadden, M.D
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT03372200: Febuxostat-Controlled, Double-Blind, Comparative Study of FYU-981 in Hyperuricemia With or Without Gout
Official title: Febuxostat-Controlled, Double-Blind, Comparative Study of FYU-981 for Hyperuricemia With or Without Gout to Evaluate the Safety and Noninferiority of FYU-981 (Phase III Study)
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE3
Conditions: Hyperuricemia With or Without Gout
Lead sponsor: Mochida Pharmaceutical Company, Ltd.
Sponsor class: INDUSTRY
Collaborators: name: Fuji Yakuhin Co., Ltd.
First posted: 2017-12-13
Enrollment: 203
Sex: ALL
Minimum age (years): 20
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: FYU-981 or Febuxostat are administrated to hyperuricemia patients (underexcretion and mixed types) with or without gout for 14 weeks to compare the efficacy and safety of these drugs by the method of multicenter, randomized, double-blind, ascending dose regimen.


Eligibility criteria: Inclusion Criteria:

* Serum urate level:

  * \>= 7.0mg/dL in patients with gouty nodule or with history of gout, or \>= 8.0mg/dL in patients with hypertension, diabetes or metabolic syndrome, or \>= 9.0mg/dL
* Disease type in the classification of hyperuricemia: Uric acid-underexcretion type or mixed type
* Outpatients

Exclusion Criteria:

* Gouty arthritis within 14 days before randomized allocation
* Secondary hyperuricemia
* HbA1c: \>= 8.4%
* Clinically significant cardiac, hepatic, renal, hematologic or endocrine disease
* Kidney calculi or clinically significant urinary calculi
* AST: \>= 100 IU/L or ALT: \>= 100 IU/L
* eGFR: \< 30 mL/min/1.73m\^2
* Systolic blood pressure: \>= 180 mmHg or diastolic blood pressure: \>= 110 mmHg

Primary outcomes:
measure: Percent reduction from baseline in serum urate level at the final visit
timeFrame: 14 weeks
Secondary outcomes:
Other outcomes:
Locations:
city: Tokyo
country: Japan
facility: Mochida Investigational sites
Study officials:
affiliation: Clinical Research Department
name: Kazuki Furuno
role: STUDY_DIRECTOR
References:
Clinical trial NCT02951000: Platysma Trial - Platysma Suturing Versus no Sutures for Wound Closure After Primary Thyroid Surgery
Official title: Platysma Trial - a Randomized Controlled Trial of Platysma Suturing Versus no Sutures for Wound Closure After Primary Thyroid Surgery
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Thyroid Disease
Keywords: thyroidectomy
postoperative pain
wound healing
Lead sponsor: University Hospital Tuebingen
Sponsor class: OTHER
First posted: 2016-11-01
Enrollment: 80
Sex: ALL
Minimum age (years): 18
Maximum age (years): 99
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: Influence of the platysma suture on postoperative pain and wound healing.

Detailed description: Does a running platysma suture after primary thyroid resection alter direct postoperative pain, wound healing and long term cosmetic results.

Primary outcome measure is if the lack of a platysma-Suture decreases the postoperative pain (detected by the visual pain score 0-10) and reduces the pain medication (detected by the cumulative NSAID and opioid treatment per patient). The second Question to be answered is if the cosmetic scar result (detected by the Patient and Observer Scar Assessment Score) 6 month after thyroidectomy is better in the intervention group (no Platysma-Suture) or not.

Eligibility criteria: Inclusion Criteria:

* primary thyroid surgery

Exclusion Criteria:

* previous neck surgery
* application of wound drainages
* preoperative diagnosed malignancy
* surgical extension beyond thyroid resection (e.g. lymphadenectomy)
* preexisting coagulopathy
* preexisting chronic pain syndromes
* preexisting dependency on pain reliefs
* preexisting disorders in wound healing (e.g. diabetes mellitus)
* intolerance to any study medication

Primary outcomes:
measure: Postoperative Pain
timeFrame: Pain at morning of the first postoperative day
Secondary outcomes:
measure: wound infection
timeFrame: within 14 days postoperative
measure: scar cosmesis
timeFrame: 6 months after surgery
measure: Postoperative Pain
timeFrame: Pain 6h after surgery, at the morning of the second postoperative day, 14 days after surgery
measure: Cervical Seroma/Hematoma
timeFrame: 14 days after surgery
measure: Disorders of the functional anatomy of the neck
timeFrame: At six months postoperative
Other outcomes:
Locations:
city: Tubingen
country: Germany
facility: University Hospital Tuebingen
Study officials:
affiliation: University Tuebigen
name: Sven Müller, MD
role: PRINCIPAL_INVESTIGATOR
References:
citation: Senne M, Zein R, Falch C, Kirschniak A, Koenigsrainer A, Muller S. Randomized clinical trial of platysma muscle suture versus no suture for wound closure after thyroid surgery. Br J Surg. 2018 May;105(6):645-649. doi: 10.1002/bjs.10829. Epub 2018 Mar 26.
Clinical trial NCT06843200: Conversations With Caregivers About Health and Appearance
Official title: Conversations With Caregivers About Health and Appearance
Study type: INTERVENTIONAL
Overall status: RECRUITING
Phase: NA
Conditions: Disordered Eating Behaviors
Depression
Feeding Behaviors
Parent-Child Relations
Lead sponsor: University of Oregon
Sponsor class: OTHER
First posted: 2025-02-24
Enrollment: 240
Sex: ALL
Minimum age (years): 12
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: PREVENTION

Brief summary: This clinical trial is evaluating the effects of a 2-hour, small group discussion with parents and caregivers of adolescents in Oregon. We will evaluate whether parents'/caregivers' experience reductions in their disordered eating symptoms, mood symptoms, and parent-child relationship quality, relative to parent/caregiver participants in the wait list control. We will also evaluate whether the children of these parents/caregivers experience improvements in their disordered eating and mood symptoms.


Eligibility criteria: Inclusion criteria for parent/caregiver:

* at least 18 years old
* the primary caregiver of at least one child 12-17 years old who lives with them at least 50% of the time
* living in the state of Oregon
* can read and understand English at the 6th grade level or higher
* access to internet and private space for zoom

Inclusion criteria for the child:

* 12-17 years of age
* can read and understand English at the 6th grade level or higher

Primary outcomes:
measure: Parent/caregiver disordered eating symptoms
timeFrame: baseline to 1-month
measure: Parent-child feeding practices
timeFrame: baseline to 1-month
measure: Parent/caregiver weight bias internalization
timeFrame: baseline to 1-month
measure: Exercise avoidance
timeFrame: baseline to 1-month
measure: Parent/caregiver self-compassion
timeFrame: baseline and 1-month
measure: Parent/child body ideal internalization
timeFrame: baseline and 1-month
measure: Parent/caregiver stress
timeFrame: baseline and 1-month
measure: Parent/caregiver fat talk
timeFrame: baseline and 1-month
measure: Parent/caregiver anti-fat attitudes
timeFrame: baseline and 1-month
Secondary outcomes:
measure: child disordered eating symptoms
timeFrame: baseline to 1-month
measure: Parent-child relationship (child report)
timeFrame: baseline to 1-month
measure: child anti-fat bias
timeFrame: baseline to 1-month
measure: Child exercise avoidance
timeFrame: baseline to 1-month
measure: fat talk (child report of parent/caregiver)
timeFrame: baseline and 1-month
measure: child weight bias internalization
timeFrame: baseline and 1-month
measure: child body ideals internalizations
timeFrame: baseline and 1-month
measure: child self-compassion
timeFrame: baseline and 1-month
Other outcomes:
Locations:
city: Eugene
country: United States
facility: University of Oregon
state: Oregon
Study officials:
References:
Clinical trial NCT05007600: Online Interactive Courses on Loneliness and Quality of Life of Older Adults
Official title: Investigating the Effectiveness of Online Interactive Courses on Loneliness and Quality of Life of Older Adults in the Community During COVID-19 Pandemic: A Pilot Study and a Randomized Controlled Trial
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Older Adults
Lead sponsor: National Cheng Kung University
Sponsor class: OTHER
First posted: 2021-08-16
Enrollment: 89
Sex: ALL
Minimum age (years): 65
Maximum age (years): 88
Standard ages: OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: HEALTH_SERVICES_RESEARCH

Brief summary: Background:

The early stage of the COVID-19 pandemic can be marked as a critical period in human history as it increased loneliness in people's lives. This is particularly true for the older adults who are single, living alone, and suffering from chronic diseases. However, there is insufficient existing research on associated interventions and their effectiveness.

Objectives:

To investigate the effectiveness of an 8-week online interactive course on the loneliness, depression, social support, and quality of life (QOL) of older adults in the community during the COVID-19 pandemic.

Methods:

This pilot study, also a single-blind randomized controlled trial, collected data from a community in central Taiwan. Participants were randomly divided into an experimental group and a control group. Subsequently, participants in the experimental group received an 8-week intensive (Monday to Friday) online interactive course, whereas those in the control group consumed 8 weeks of unidirectional online video and audio programs (such as from YouTube). Assessments were conducted both before and after the intervention, with the primary outcome being the UCLA Loneliness Scale (UCLA), and secondary outcomes being the Geriatric Depression Scale Short Form, the Inventory of Socially Supportive Behavior (ISSB) Scale, and the WHO Quality of Life-BREF (WHOQOL-BREF) Scale.


Eligibility criteria: Inclusion Criteria:

* (1) senior residents aged over 60 years, those who were not diagnosed with any cognitive impairment;
* (2) capable of communicating in Mandarin or Taiwanese; and
* (3) capable of using smartphones.

Exclusion Criteria:

* (1) participants who could not fully complete the 8-week intervention (or participate in the course for at least three days per week); and
* (2) those who were incapable of understanding the content of the questionnaire.

Primary outcomes:
measure: UCLA Loneliness Scale (UCLA)
timeFrame: 10-20 minutes
Secondary outcomes:
measure: Geriatric Depression Scale Short Form (GDS-SF)
timeFrame: 10-20 minutes
measure: Inventory of Socially Supportive Behavior (ISSB) Scale
timeFrame: 10-20 minutes
measure: WHO Quality of Life-BREF (WHOQOL-BREF) Scale
timeFrame: 10-20 minutes
Other outcomes:
Locations:
city: Taichung
country: Taiwan
facility: Asia Univeraity
state: WuFeng
Study officials:
References:
Clinical trial NCT04791800: Clinical Evaluation of the STANDARD™ Q Malaria/CRP Duo Test
Official title: Evaluation of the Clinical Performance of the STANDARD™ Q Malaria/CRP Duo Test (SD Biosensor, South Korea) for the Diagnosis of Malaria and the Detection of C-reactive Protein (CRP) in Fingerprick Blood of Febrile Patients
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Fever Malaria
Keywords: malaria
fever
C-reactive protein
point-of-care testing
Lead sponsor: Foundation for Innovative New Diagnostics, Switzerland
Sponsor class: OTHER
Collaborators: name: National Institute of Malaria Research, New Delhi, India
First posted: 2021-03-10
Enrollment: 1808
Sex: ALL
Minimum age (years): 5
Standard ages: CHILD
ADULT
OLDER_ADULT
Observational model: CASE_ONLY
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Patients aged 5 years and above with clinically suspected malaria on the basis of fever or history of fever in the previous 72 h, either enrolled by passive case detection in health care facilities, or by active case detection in the surrounding communities.

Brief summary: The aim of this study is to assess the clinical performance (sensitivity, specificity, positive and negative predictive values) of the STANDARD™ Q Malaria/CRP Duo Test when used by health care workers (HW) in a point of care (POC) setting in malaria endemic areas in India. Performance will be assessed in comparison with expert microscopy as the reference test for malaria, and with a high quality, commercially available C-Reactive Protein (CRP) test kit run on a laboratory machine as a reference test for CRP.


Eligibility criteria: Inclusion Criteria:

* clinically suspected malaria on the basis of fever or history of fever in the previous 72 h
* age ≥ 5 years, (iii) having been informed of the study and signed a written consent form

Exclusion Criteria:

* signs of severe malaria or other severe disease
* patients not fulfilling the inclusion criteria.

Primary outcomes:
measure: Clinical performance of the Malaria/CRP combination test for malaria diagnosis at day 0
timeFrame: Day 0
measure: Clinical performance of the Malaria/CRP combination test for detection of high levels of C-reactive protein at day 0
timeFrame: Day 0
Secondary outcomes:
Other outcomes:
Locations:
city: New Delhi
country: India
facility: NIMR
Study officials:
affiliation: National Institute of Malaria Research, New Delhi, India
name: Anupkumar Anvikar, MD
role: PRINCIPAL_INVESTIGATOR
References: