Clinical trial NCT04740359: Functional Trunk Training in Ataxia Patients
Official title: The Effect of Functional Trunk Training on Trunk Control and Upper Extremity Functions in Hereditary Ataxia Patients With Autosomal Recessive
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Ataxia, Spinocerebellar
Ataxias, Hereditary
Keywords: ataxia,rehabilitation,trunk,disabilities
Lead sponsor: Hasan Kalyoncu University
Sponsor class: OTHER
First posted: 2021-02-05
Enrollment: 20
Sex: ALL
Minimum age (years): 5
Maximum age (years): 18
Standard ages: CHILD
ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Intervention model description: Participants were divided in two groups. Two groups will get two different intervention.
Primary purpose: TREATMENT

Brief summary: The study is to examine the effect of functional trunk training on trunk control and upper extremity functions in patients with autosomal recessive ataxia.

Detailed description: Hereditary ataxias are a group of genetic diseases characterized by slow progressive gait disturbance. In addition, coordination disorders can be seen in extremities, speech and eye movements. Atrophy is common in the cerebellum. Friedreich's ataxia, ataxia telangiectasia, ataxia with vitamin E deficiency, infantile-onset spinocerebellar atrophy and Marinesco-Sjögren syndrome are autosomal recessive hereditary ataxias. The constant main sign of autosomal recessive ataxia is progressive ataxia.

The trunk has an important role on dynamic stabilization for postural reactions and limb movements. A good trunk support enables movements in other parts of the body to occur more regularly. Trunk stabilization is important to support upper and lower extremity movements, to meet the loads, and to protect the spinal cord. The relationship between upper extremity function, daily living activities and trunk functions has been emphasized in many studies but comparative studies about the rehabilitation were very less.

This study is to evaluate the effect o functional trunk training in patients with autosomal recessive ataxia.

Eligibility criteria: Inclusion Criteria:

* Without any communication impairment (seeing, hearing, hearing),
* Have not had surgery for the upper and lower extremities in the last 6 months,
* Between the ages of 5 and 18,
* The mental level determined by the pediatrician is sufficient,

Exclusion Criteria:

* Patients who want to leave the study at any stage of the study
* Patients who do not attend regular training

Primary outcomes:
measure: The Functional Independence
timeFrame: through of te study, average 8 weeks
measure: Trunk impairment
timeFrame: through of te study, average 8 weeks
measure: The severity of ataxia
timeFrame: through of te study, average 8 weeks
measure: The quality of life
timeFrame: through of te study, average 8 weeks
Secondary outcomes:
measure: Upper extremity functional performance
timeFrame: through of te study, average 8 weeks
measure: Functional Reach Test
timeFrame: through of te study, average 8 weeks
Other outcomes:
Locations:
city: Gaziantep
country: Turkey
facility: Hasan kalyoncu üniversitesi
state: Eyalet/Yerleşke
Study officials:
References:
citation: Freund JE, Stetts DM. Use of trunk stabilization and locomotor training in an adult with cerebellar ataxia: a single system design. Physiother Theory Pract. 2010 Oct;26(7):447-58. doi: 10.3109/09593980903532234.
citation: Van de Warrenburg BP, Bakker M, Kremer BP, Bloem BR, Allum JH. Trunk sway in patients with spinocerebellar ataxia. Mov Disord. 2005 Aug;20(8):1006-13. doi: 10.1002/mds.20486.
citation: Corben LA, Tai G, Wilson C, Collins V, Churchyard AJ, Delatycki MB. A comparison of three measures of upper limb function in Friedreich ataxia. J Neurol. 2010 Apr;257(4):518-23. doi: 10.1007/s00415-009-5352-7. Epub 2009 Oct 13.
citation: Freund JE, Stetts DM, Vallabhajosula S. Relationships between trunk performance, gait and postural control in persons with multiple sclerosis. NeuroRehabilitation. 2016 Jun 30;39(2):305-17. doi: 10.3233/NRE-161362.