louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT01727219: COPD Assessment Test Can Predict Depression
Official title: COPD Assessment Test Can Predict Depression
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Depression,
COPD
Lead sponsor: Hallym University Medical Center
Sponsor class: OTHER
First posted: 2012-11-15
Enrollment: 600
Sex: ALL
Minimum age (years): 40
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: CROSS_SECTIONAL
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Stable COPD patients who visit outpatient departments.

Brief summary: The frequency of depression in COPD patients are substantial and early detection and prevention of depression is critical.

Recently, COPD assessment test (CAT) was developed and validated to assess the impact of COPD on patients' quality of life.

In this prospective study, we will investigate the predictive utility of CAT for predicting depression in COPD patients.

Detailed description: This study is aimed to investigate the association between the COPD Assessment Test (CAT) and depression in stable COPD patients. Stable COPD patients will be enrolled from the tertiary hospitals. All patients will undergo lung function tests. The Korean versions of the CAT (COPD assessment test) and Patient Health Questionnaire-9 (PHQ-9) will be used to assess COPD symptoms and depressive disorder, respectively.

We will compare the depresssion frequency among GOLD classifications of airway limitation and among the four CAT groups. And. we will also investigate which items of the CAT are the strongest indicators of depression.

Eligibility criteria: Inclusion Criteria:

* COPD patients who aged \> or = 40 years

Exclusion Criteria:

* acute exacerbation within 3 months
* bronchial asthma or an increase in FEV1 of more than 12% of the predicted value with the use of 400 µg of albuterol.
* other lung diseases such as bronchiectasis, interstitial lung disease, and tuberculosis-destroyed lungs.
* who denied to consent.

Primary outcomes:
measure: The predictive utility of the COPD assessment test (CAT) scores for predicting depression in COPD patients
timeFrame: 1 year
Secondary outcomes:
Other outcomes:
Locations:
city: Anyang-
country: Korea, Republic of
facility: Hallym University Sacred Heart Hospital, Department of Pulmonary, Critical Care Medicine
state: Gyeonggi-do
Study officials:
affiliation: Hallym University Medical Center
name: KI-Suck Jung, Dr.
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT00991419: To Compare Positron Emission Tomography (PET) Measurements of Fibrillar Amyloid Burden
Official title: A Phase II, Open Label, Non-Randomized Study of [18F]AZD4694 to Compare PET Measurements of Fibrillar Amyloid Burden Obtained Using Difference Scanning Parameters, Reference Region Procedures and to Assess Test-retest Reliability in Patients With AD & HV
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE2
Conditions: Alzheimer's Disease
Keywords: PET
Alzheimer's disease
diagnostic
Lead sponsor: AstraZeneca
Sponsor class: INDUSTRY
First posted: 2009-10-08
Enrollment: 25
Sex: ALL
Minimum age (years): 18
Maximum age (years): 80
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: NON_RANDOMIZED
Intervention model: SINGLE_GROUP
Primary purpose: DIAGNOSTIC

Brief summary: The purpose of this study is to compare PET measurements of fibrillar amyloid burden using \[18F\]AZD4694.


Eligibility criteria: Inclusion Criteria:

* Male or female, of any race or/ethnicity
* ECG, vital signs, and clinical laboratory values are within normal limits at enrollment or deemed not clinically significant by the physician

Exclusion Criteria:

* Significant recent (within 6 months) history of neurological (including stroke) or psychiatric disorder or substance abuse
* Participated in a PET study within the last 12 months
* Pregnancy or lactation

Primary outcomes:
measure: PET Measurements
timeFrame: Day 1 and Day 7
Secondary outcomes:
Other outcomes:
Locations:
city: Phoenix
country: United States
facility: Research Site
state: Arizona
Study officials:
affiliation: Banner Alzheimer's Institute
name: Eric M Reiman, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT00875719: Oxygen Portable Concentrator During Exercises in Patients With COPD
Official title: Comparing Effectiveness of Oxygen Supplementation From a Portable Concentrator and a Liquid Oxygen Source During Walking Test in COPD Patients With Respiratory Failure
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Chronic Obstructive Pulmonary Disease
Keywords: COPD patients with respiratory failure
Lead sponsor: Association Nationale pour les Traitements A Domicile, les Innovations et la Recherche
Sponsor class: OTHER
First posted: 2009-04-03
Enrollment: 19
Sex: ALL
Minimum age (years): 45
Maximum age (years): 80
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: SINGLE_GROUP
Primary purpose: TREATMENT

Brief summary: The purpose of this study is to compare differences in oxygen delivery between portable oxygen concentrators (POCs) and liquid oxygen (LOs) portable units, pose a question if POCs are equally effective as LOs in reducing exercise-induced hypoxaemia. DESIGN: Randomized, single-blind clinical trial.

Detailed description: Our primary objective is to compare at rest and during exercise the evolution of oxygen saturation and dyspnea during 6 minutes walking test in patients with COPD receiving oxygen supplementation either with portable concentrators or liquid oxygen in a random order.

Eligibility criteria: Inclusion Criteria:

* COPD with respiratory failure and indication for oxygen supplementation at rest and/or during exercice.

Exclusion Criteria:

* Evolutive heart disease.
* Unability to understand or realize the tests.
* Acute exacerbation during the last month.

Primary outcomes:
measure: Oxygen Saturation
timeFrame: One day
Secondary outcomes:
measure: Walking Distance
timeFrame: One day
Other outcomes:
Locations:
city: LIMOGES cedex
country: France
facility: Service de Pneumologie et Allergologie- Hôpital le Cluzeau. 23 av. D. Larrey
Study officials:
affiliation: Association Nationale pour les Traitements A Domicile, les Innovations et la Recherche
name: Boris MELLONI, Pr
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT00292019: Robotic Laparoscopic Radical Prostatectomy
Official title: Robotic Laparoscopic Radical Prostatectomy
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Prostate Cancer
Lead sponsor: London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Sponsor class: OTHER
First posted: 2006-02-15
Enrollment: 20
Sex: MALE
Minimum age (years): 40
Maximum age (years): 65
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Prostate cancer patients eligible for a radical prostatectomy

Brief summary: This is a pilot study to evaluate the role of RALRP in the management of localized prostate cancer.

Detailed description: To establish a robotic-assisted laparoscopic radical prostatectomy programme at the University of Western Ontario/London Health Sciences Centre and to critically evaluate the role of this programme in the management of localized prostate cancer in surgical candidates Details of surgical procedure, operative outcome, patient outcome including quality of life will be collected.

Eligibility criteria: Inclusion Criteria:

1. Informed Consent
2. Locally confined, stage T1a, T2a or T2b prostate cancer
3. Aged 40-65 and judged by the study doctor to be a suitable candidate for a radical prostatectomy.
4. Serum prostate specific antigen equal to or less than 10mg/ml
5. Histologically confirmed adenocarcinoma of the prostate
6. Gleason score equal to or less than 7
7. Life expectancy of greater than 10 years.
8. Prostate size on TRUS measurement less than 40 grams

Exclusion Criteria:

1. Patients who have undergone prior hormone therapy.
2. Patients with a previous transurethral resectioning of the prostate (TURP)
3. History of other cancers other than basal cell carcinoma.
4. Patients with any prior abdominal surgery.
5. Any condition, or history of illness or surgery than, in the opinion of the investigator, might confound the results of the study or pose additional risk to the patient (eg significant cardiovascular conditions)
6. Patients with a large median lobe of the prostate. -

Exclusion Criteria:

-

Primary outcomes:
Secondary outcomes:
Other outcomes:
Locations:
city: London
country: Canada
facility: London Health Sciences Centre
state: Ontario
Study officials:
affiliation: London Health Sciences Centre
name: Joseph Chin, MD< FRCSC
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT06901219: The Effect of Fatigue on Static and Dynamic Balance in Healthy Young Male Athletes
Official title: The Effect of Fatigue on Static and Dynamic Balance in Healthy Young Male Athletes
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Fatigue
Keywords: Static Balance
Athletes
Dynamic Balance
Lactate
Lead sponsor: Kuwait University
Sponsor class: OTHER
First posted: 2025-03-28
Enrollment: 40
Sex: MALE
Minimum age (years): 18
Maximum age (years): 24
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: PREVENTION

Brief summary: Participants were randomized into control and experimental groups. They were examined on static and dynamic balance (pre- \& post-tests). Then, the experimental group went through a fatigue protocol, in which speed and incline increase one unit each minute passing, and stopped when rate of perceived exertion level reached ≥ 18, and the plasma lactate level differed from the baseline by ≥ 4mmol/L.


Eligibility criteria: Inclusion Criteria:

* male and aged between 18-24 years old,
* physically active (i.e. exercised ≥ 3 times weekly during the past three months).

Exclusion Criteria:

* reported a minor injury in the past two months,
* major injury in the past 12 months, and/or underwent a major primary surgery in their lower limb.

Primary outcomes:
measure: Dynamic Balance
timeFrame: Baseline and immediately after the protocol
measure: Static balance
timeFrame: Baseline and immediately after the protocol
Secondary outcomes:
Other outcomes:
Locations:
city: Safat
country: Kuwait
facility: Kuwait University
Study officials:
References:
citation: Wikstrom EA. Validity and reliability of Nintendo Wii Fit balance scores. J Athl Train. 2012 May-Jun;47(3):306-13. doi: 10.4085/1062-6050-47.3.16.
citation: Clark RA, Mentiplay BF, Pua YH, Bower KJ. Reliability and validity of the Wii Balance Board for assessment of standing balance: A systematic review. Gait Posture. 2018 Mar;61:40-54. doi: 10.1016/j.gaitpost.2017.12.022. Epub 2017 Dec 30.
citation: Kluger BM, Krupp LB, Enoka RM. Fatigue and fatigability in neurologic illnesses: proposal for a unified taxonomy. Neurology. 2013 Jan 22;80(4):409-16. doi: 10.1212/WNL.0b013e31827f07be.
citation: Bogdanis GC. Effects of physical activity and inactivity on muscle fatigue. Front Physiol. 2012 May 18;3:142. doi: 10.3389/fphys.2012.00142. eCollection 2012.
Clinical trial NCT05278819: Upper Extremity Elevation and Lungfunction After Open Heart Surgery
Official title: Effects of Upper Extremity Elevation and Deep Breathing on Oxygen Saturation and Lung Volume Two to Four Days After Open Heart Surgery
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Heart Diseases
Heart Diseases, Ischemic
Heart Disease, Valvular
Lead sponsor: Region Örebro County
Sponsor class: OTHER
Collaborators: name: Region Örebro County
name: Linkoeping University
name: Örebro University, Sweden
First posted: 2022-03-14
Enrollment: 22
Sex: ALL
Minimum age (years): 18
Maximum age (years): 100
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: CROSSOVER
Primary purpose: TREATMENT

Brief summary: The purpose of this study is to assess if arm elevation, with or without simultaneous deep breathing, affects oxygen saturation and lung function on patients two to four days after open heart surgery.

Detailed description: This single center, interventional crossover study will involve patients day 2, 3 or 4 after open heart surgery. Patients who meet the eligibility requirements will be informed about the study and potential risks, given a written informed consent they will be included for intervention being held later on the same day. Randomization will be given to the investigator in a sealed envelope and being opened after base line measurements. Data will then be collected for the randomized intervention and after a wash out period (several minutes) again for the crossover intervention.

Eligibility criteria: Inclusion Criteria:

* open heart surgery at university hospital in Örebro

Exclusion Criteria:

* not able to communicate in swedish
* difficulties in cooperating during measurements
* cognitive impairement
* prolonged stay at ICU (still at ICU on the day of investigation)
* ongoing oxygen treatment with more than 5 liter/minut (FiO \> 40 %)

Primary outcomes:
measure: peripheral oxygen saturation
timeFrame: 30 minutes
Secondary outcomes:
measure: tidal volume
timeFrame: 30 minutes
measure: heart rate
timeFrame: 30 minutes
measure: respiratory rate
timeFrame: 30 minutes
measure: pain - numeric rating scale
timeFrame: 30 minutes
measure: dyspnea - numeric rating scale
timeFrame: 30 minutes
measure: exertion - numeric rating scale
timeFrame: 30 minutes
Other outcomes:
Locations:
city: Örebro
country: Sweden
facility: University Hospital
Study officials:
References:
Clinical trial NCT01936818: Study Evaluating Nasal Symptoms Induced by a Nasal Allergen Challenge (NAC) To House Dust Mite Allergen
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Allergic Rhinitis
Lead sponsor: ORA, Inc.
Sponsor class: INDUSTRY
First posted: 2013-09-06
Enrollment: 21
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: CASE_ONLY
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: subjects at least 18 years of age of either sex and any race

Brief summary: A Multi-Center Study Evaluating the Nasal Allergic Symptomatology Induced by a Nasal Allergen Challenge (NAC) in a Dust Mite Population


Eligibility criteria: Inclusion Criteria:

* be at least 18 years of age
* positive ST to Dust Mite
* history of allergic rhinitis

Exclusion Criteria:

* no active infections
* no disallowed medications
* no nasal anatomical deformities or nasal surgical interventions in the past

Primary outcomes:
measure: TNSS= total nasal symptoms score
timeFrame: 15 minutes
Secondary outcomes:
measure: Individual nasal symptoms
timeFrame: 15 minutes
Other outcomes:
Locations:
city: Andover
country: United States
facility: Ora Clinical Research Center
state: Massachusetts
Study officials:
References:
Clinical trial NCT06328218: The Effect of Simple Gymnastics Training for Parkinson's Patients in the Community
Official title: A The Effect of Simple Gymnastics Training for Parkinson's Patients in the Community: A Preliminary Study
Study type: INTERVENTIONAL
Overall status: NOT_YET_RECRUITING
Phase: NA
Conditions: Parkinson Disease
Lead sponsor: Chao Phya Abhaibhubejhr Hospital
Sponsor class: OTHER_GOV
First posted: 2024-03-25
Enrollment: 200
Sex: ALL
Minimum age (years): 60
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: TREATMENT

Brief summary: The goal of this clinical trial is to explore the impact of Simple Gymnastics Training on Limb motor function and mental health in Parkinson's Patients in the Community (≥60 year old) with swallowing disorders. It primarily aims to address two key aspects: 1) the prevalence of Parkinson's Diseases among community-dwelling elderly individuals, and 2) the effects of Simple Gymnastics Training on Limb motor function and mental health in community-dwelling Parkinson's Patients. All patients are required to undergo a continuous three-week (21 days) Simple Gymnastics Training, with weekends off and training conducted only on weekdays. The training will be conducted two sessions per day, lasting 30 minutes each.

Detailed description: In the early stages of Parkinson's disease, many patients do not seek medical attention. The goal of this clinical trial is to explore the impact of Simple Gymnastics Training on Limb motor function and mental health in Parkinson's Patients in the Community (≥60 year old) with swallowing disorders. It primarily aims to address two key aspects: 1) the prevalence of Parkinson's Diseases among community-dwelling elderly individuals, and 2) the effects of Simple Gymnastics Training on Limb motor function and mental health in community-dwelling Parkinson's Patients. All patients are required to undergo a continuous three-week (21 days) Simple Gymnastics Training, with weekends off and training conducted only on weekdays. The training will be conducted two sessions per day, lasting 30 minutes each.

Eligibility criteria: Inclusion Criteria:

* Age \>60 years.
* Meeting the diagnostic criteria for Parkinson's disease developed by the Neurology Branch of the Chinese Medical Association in 2006.

Exclusion Criteria:

* Complicated with cognitive impairment or consciousness dysfunction.
* Simultaneously suffering from severe liver, kidney failure, tumors, or hematological diseases.
* Complicated with severe liver and kidney failure, tumors, or hematological disorders.:

Primary outcomes:
measure: Unified Parkinson's Disease Rating Scale
timeFrame: day 1 and day 21
Secondary outcomes:
measure: The Berg Balance Scale
timeFrame: day 1 and day 21
measure: Patient Health Questionnaire-9
timeFrame: day 1 and day 21
Other outcomes:
Locations:
Study officials:
References:
Clinical trial NCT04509518: Effectiveness of Selected Physical Therapy Exercise Program and Transcutaneous Electrical Nerve Stimulation on Patients With Pudendal Neuralgia
Official title: The Effectiveness of Selected Physical Therapy Exercise Program With or Without Transcutaneous Electrical Nerve Stimulation on Male Patients With Pudendal Neuralgia
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Pudendal Neuralgia
Lead sponsor: Cairo University
Sponsor class: OTHER
First posted: 2020-08-12
Enrollment: 52
Sex: MALE
Minimum age (years): 30
Maximum age (years): 50
Standard ages: ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: To study the efficacy of adding Transcutaneous Electrical Nerve Stimulation (TENS) to selected physical therapy exercise program on pain in patients with pudendal neuralgia.

Fifty-two male participants with chronic pudendal neuralgia (30-50 years) shared in this study.

Methods: patients were assigned randomly into two groups equal in number; study and control groups with 26 patients in each. All patients were receiving the same physical therapy exercise program, in addition to the same prescribed analgesic medication. Patients in the study group received additional TENS therapy and those in the control group received sham TENS. Treatment was provided three sessions per week for twelve successive weeks. The participants underwent baseline and post treatment assessment for pain level as measured by three methods; Serum Cortisol Level (SCL), Daily Etodolac intake dose (DEID), and Numerical Pain Rating Scale (NPRS).


Eligibility criteria: Inclusion Criteria:

* Nonsmoking male patients
* Diagnosed as having unilateral pudendal nerve entrapment resulting in pudendal neuralgia
* Ages ranged between 30 to 50 years
* Did not have any behavioral or cognitive impairments that could prevent them from following simple verbal commands or instructions during tests and training.

Exclusion Criteria:

* Those who had history of skin malignancy
* Diabetes
* Sensory disorders
* Circulatory insufficiency
* Acute infection of the treatment area
* Renal failure
* Myocardial infarction
* Communication problems, or those with pace maker

Primary outcomes:
measure: Neumerical rating scale
timeFrame: 12 weeks
Secondary outcomes:
Other outcomes:
Locations:
city: Cairo
country: Egypt
facility: Marwa Eid
Study officials:
References:
Clinical trial NCT02690818: Promoting Adherence to Treatment for Latent TB Infection Through Text Messaging
Official title: Promoting Adherence to Treatment for Latent TB Infection Through Mobile Phone Text Messaging
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Latent Tuberculosis
Keywords: Tuberculosis
Latent Tuberculosis
Texting
Adherence
Medication
Lead sponsor: University of Arizona
Sponsor class: OTHER
Collaborators: name: Pima County Health Department
name: American Lung Association
First posted: 2016-02-24
Enrollment: 30
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: PREVENTION

Brief summary: The purpose of this pilot study is to determine whether regularly scheduled medication reminder text messages (SMS) are effective in increasing latent tuberculosis infection (LTBI) treatment completion.

Detailed description: We aim to determine the feasibility and acceptability of text reminders for improving adherence in latent TB patients. Specific objectives of the current study are to: 1) Assess the feasibility of the intervention as indicated by participant recruitment and retention and; 2) Evaluate the acceptability of the intervention, as indicated by intervention adherence, outcome measurement rates, and feedback from participants.

Data will be used to design a definitive trial which will test the hypothesis that the intervention will improve medication adherence, as measured through an increase in treatment completion rates, and result in higher self-reported medication adherence, fewer missed appointments and doses, and a shorter course of treatment.

Eligibility criteria: Inclusion Criteria:

* Consent to the study
* Own a mobile phone which operates on a telecom provider supported by our SMS platform
* Initiating or actively receiving treatment for LTBI at the Pima County TB Clinic in Tucson, AZ
* Prescribed self-administered therapy
* Report not having prior or current active TB disease
* Know how to and are able to receive SMS messages
* At least 18 years of age

Exclusion Criteria:

* Do not meet inclusion criteria
* Do not consent to study

Primary outcomes:
measure: Recruitment
timeFrame: Ongoing
Secondary outcomes:
measure: Retention
timeFrame: Ongoing
measure: Perceptions of Intervention through a questionnaire
timeFrame: Once, up to 12 months post-treatment
Other outcomes:
Locations:
city: Tucson
country: United States
facility: Pima County Health Department
state: Arizona
Study officials:
affiliation: University of Arizona
name: Eyal Oren, PhD
role: PRINCIPAL_INVESTIGATOR
References:
citation: Oren E, Bell ML, Garcia F, Perez-Velez C, Gerald LB. Promoting adherence to treatment for latent TB infection through mobile phone text messaging: study protocol for a pilot randomized controlled trial. Pilot Feasibility Stud. 2017 Mar 13;3:15. doi: 10.1186/s40814-017-0128-9. eCollection 2017.