Clinical trial NCT06439251: Effects of Mulligan Technique With or Without Diclofenac Phonophoresis on Patellofemoral Pain Syndrome.
Official title: Effects of Mulligan Technique With or Without Diclofenac Phonophoresis on Pain, Range of Motion and Functional Disability of Knee Joint in Patients With Patellofemoral Pain Syndrome
Study type: INTERVENTIONAL
Overall status: RECRUITING
Phase: PHASE1
PHASE2
Conditions: Patellofemoral Pain Syndrome
Keywords: Patellofemoral Pain Syndrome,
Mulligan mobilization
Phonophoresis
diclofenac
Lead sponsor: University of Lahore
Sponsor class: OTHER
First posted: 2024-06-03
Enrollment: 68
Sex: ALL
Minimum age (years): 20
Maximum age (years): 45
Standard ages: ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The patellofemoral pain syndrome (PFPS) is a common cause for "anterior knee pain" and mainly affects young women. the effectiveness of Mulligan technique with or without diclofenac phonophoresis on pain, range of motion and functional disability of knee joint in patients with patellofemoral pain syndrome is known little. This study, ethically approved, focused on patients with anterior knee pain referred to the Physical Therapy Department from Lahore General Hospital. After eligibility assessments and consent, participants were randomly assigned to Group A (Experimental) or Group B (Control). Over four weeks, three sessions per week, routine physiotherapy and specific exercises will be administered, with Group A receiving additional Phonophoresis using ultrasound and diclofenac gel. Outcome variables (Numeric Pain Rating Scale, KOOS-PF, Universal Goniometer) will be assessed by a blinded assessor at baseline and study completion.

Detailed description: Background: The patellofemoral pain syndrome (PFPS) is a common cause for "anterior knee pain" and mainly affects young women without any structural changes such as increased Q-angle or significant pathological changes in articular cartilage.

Objective: To evaluate the effectiveness of Mulligan technique with or without diclofenac phonopheresis on pain, range of motion and functional disability of knee joint in patients with patellofemoral pain syndrome.

Methodology: This study, ethically approved, focused on patients with anterior knee pain referred to the Physical Therapy Department from Lahore General Hospital. After eligibility assessments and consent, participants were randomly assigned to Group A (Experimental) or Group B (Control). Over four weeks, three sessions per week, routine physiotherapy and specific exercises were administered, with Group A receiving additional Phonophoresis using ultrasound and diclofenac gel. Outcome variables (Numeric Pain Rating Scale, KOOS-PF, Universal Goniometer) were assessed by a blinded assessor at baseline and study completion.

Eligibility criteria: Inclusion Criteria:

* • Patients of age range 20-45 years and both genders (Rehman, 2021 #171)

  * Unilateral anterior knee pain persisting for over two months, referred by orthopedic (Rehman, 2021 #171)
  * Pain scoring rate on numeric pain rating scale (NPRS) \>3 during at least two activities (Rehman, 2021 #171)
  * Patients with positive Clarke's test/ Patellar grind test (Rehman, 2021 #171)
  * Pain while going up and down stairs, when sitting with knees flexed and with squatting, kneeling or returning from squat. (Powers, 2017 #172)

Exclusion Criteria:

* • Patients with other knee pathologies; meniscus tears, bursitis, patellar tendon injury, ligamentous injury

  * Degenerative joint disorders; knee osteoarthritis, rheumatoid arthritis etc.
  * Patellofemoral dislocation and / or frequent subluxation.
  * Patients having undergone lower extremity surgery
  * Those taking any pain medications

Primary outcomes:
measure: Numeric Pain Rating Scale
timeFrame: 4 weeks
measure: KOOS-PF Scale
timeFrame: 4 weeks
measure: Universal Goniometer
timeFrame: 4 weeks
Secondary outcomes:
Other outcomes:
Locations:
city: Lahore
country: Pakistan
facility: Lahore General Hospital
state: Punjab
Study officials:
affiliation: University of Lahore
name: Zunaira Saeed, Masters
role: PRINCIPAL_INVESTIGATOR
affiliation: University of Lahore
name: Umber Nawaz, PhD Scholar
role: PRINCIPAL_INVESTIGATOR
affiliation: University of Lahore
name: Ashfaq Ahmad, PhD
role: STUDY_CHAIR
References: