Clinical trial NCT05997251: The Relationship of DASH and Mediterranean Diet Score With Serum Adiponectin Levels in Patients With Spinal Cord Injury
Official title: The Relationship of DASH and Mediterranean Diet Score With Serum Adiponectin Levels in Patients With Spinal Cord Injury
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Spinal Cord Injuries
Keywords: Adiponectin
Lead sponsor: Ankara City Hospital Bilkent
Sponsor class: OTHER
First posted: 2023-08-18
Enrollment: 66
Sex: ALL
Minimum age (years): 18
Maximum age (years): 65
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: CASE_CONTROL
Time perspective: CROSS_SECTIONAL
Sampling method: PROBABILITY_SAMPLE
Study population: Patients admitted to hospital Healthy population from patient care givers of hospital staff

Brief summary: The aim of this study is to reveal the relationship of DASH and Mediterranean diet score with anthropometric measurements and serum adiponectin level in individuals with spinal cord injury. This research was planned as a cross-sectional, case-control study. With the data to be obtained from the research, information will be obtained about the hormonal or biochemical basis of metabolic disorders such as atherosclerosis and insulin resistance that may occur in individuals with spinal cord injury in the long term.

20 individuals with Spinal Cord Injury will be included in the study, and the results of the patients will be compared with 20 healthy individuals. In order to determine the food consumption status of the patients, a 1-day food consumption record will be requested. DASH diet score and Mediterranean diet score will be calculated from dietary records. After 8 hours of fasting, 3 ml of peripheral blood will be taken for the measurement of adiponectin between 08:00 and 09:00 in the morning from the individuals in the study and control groups. Adiponectin level will be measured and its correlation with DASH diet score and Mediterranean diet score will be examined.


Eligibility criteria: Inclusion Criteria:

* Inclusion criteria (Study group)

  * Having spent at least 6 months after spinal cord injury
  * 1st motor neuron injury
  * Being between the ages of 18-65
  * Giving consent to participate in the study Inclusion criteria (Control group)
  * Being between the ages of 18-65
  * Giving consent to participate in the study

Exclusion Criteria:

* Exclusion criteria (Study group)

  * Having an additional disease to the spinal cord injury
  * Having a 2nd motor neuron lesion

Exclusion criteria (Control group)

• Having any disease

Primary outcomes:
measure: Adiponectin level
timeFrame: Will be measured at inclusion
measure: DASH diet score
timeFrame: Will be measured at inclusion from one day dietary record
measure: Mediterrenian diet score
timeFrame: Will be measured at inclusion from one day dietary record
Secondary outcomes:
measure: Whole blood count
timeFrame: Will be measured at inclusion
measure: Fasting blood glucose
timeFrame: Will be measured at inclusion
measure: Total cholesterol
timeFrame: Will be measured at inclusion
measure: LDL
timeFrame: Will be measured at inclusion
measure: HDL
timeFrame: Will be measured at inclusion
measure: TG
timeFrame: Will be measured at inclusion
Other outcomes:
Locations:
city: Ankara
country: Turkey
facility: Ankara Bilkent City Hospital Physical Treatment and Rehabilitation Hospital
Study officials:
References:
citation: Wang YH, Huang TS, Liang HW, Su TC, Chen SY, Wang TD. Fasting serum levels of adiponectin, ghrelin, and leptin in men with spinal cord injury. Arch Phys Med Rehabil. 2005 Oct;86(10):1964-8. doi: 10.1016/j.apmr.2005.04.017.
citation: Ekmekci H, Ekmekci OB. The role of adiponectin in atherosclerosis and thrombosis. Clin Appl Thromb Hemost. 2006 Apr;12(2):163-8. doi: 10.1177/107602960601200203.
citation: O'Brien LC, Graham ZA, Chen Q, Lesnefsky EJ, Cardozo C, Gorgey AS. Plasma adiponectin levels are correlated with body composition, metabolic profiles, and mitochondrial markers in individuals with chronic spinal cord injury. Spinal Cord. 2018 Sep;56(9):863-872. doi: 10.1038/s41393-018-0089-8. Epub 2018 Mar 20.