louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT05109299: Antibacterial Effect of Miswak Toothpaste Compared to Fluoride Toothpaste
Official title: Antibacterial Effect of Miswak Toothpaste Compared to Fluoride Toothpaste in High Caries Risk Patients: Randomized Clinical Trial
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Caries
Keywords: Antibacterial, streptococcus mutans, miswak, fluoride
Lead sponsor: Cairo University
Sponsor class: OTHER
First posted: 2021-11-05
Enrollment: 32
Sex: ALL
Minimum age (years): 18
Maximum age (years): 25
Standard ages: ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: Meswak is scientifically formulated herbal toothpaste with pure extract of the Miswak plant 'Salvadore Persica', the famous 'Toothbrush Tree' used for centuries. The astringent and anti-bacterial properties of Meswak helps reduce tooth decay , fight plaque and prevent gum diseases. Miswak Herb is a rare, potent, priceless, wonder herb that delivers incredible Dental Care benefits.

Detailed description: This study is a randomized clinical trial, with parallel study design, 1:1 allocation ratio and superiority framework. The aim of the current trial is to evaluate antibacterial effect miswak toothpaste compared to fluoride toothpaste in high caries risk patients.

Eligibility criteria: Inclusion Criteria:

* High caries risk patients.
* At least one carious tooth according to CAT caries risk assessment model.
* Patient compliance

Exclusion Criteria:

* Participant in another trial.
* Using another antimicrobial agents since one month of sampling.
* Systemic diseases or concomitant medication affecting salivary flow.
* Parafunctional habits.
* Pregnancy.

Primary outcomes:
measure: streptococcus mutans count
timeFrame: 3 months
Secondary outcomes:
Other outcomes:
Locations:
city: Cairo
country: Egypt
facility: Faculty of Dentistry, Cairo University
state: El Manial
Study officials:
affiliation: Lecturer, Conservative Dentistry Department, Faculty of Dentistry, Cairo University
name: Omar O Shaalan, PhD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT03320499: Impact on Patient Satisfaction About Realization of Ultrasound Dopplers at the Bed
Official title: Impact on Patient Satisfaction About Realization of Ultrasound Dopplers at the Bed
Study type: OBSERVATIONAL
Overall status: WITHDRAWN
Conditions: Ultrasound Doppler
Lead sponsor: Fondation Hôpital Saint-Joseph
Sponsor class: OTHER
First posted: 2017-10-25
Enrollment: 0
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: CASE_CONTROL
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: patients hospitalized in vascular yard of GHPSJ

Brief summary: Organisation and logistic about realisation of vascular doppler ultrasound is something very eclectic . Need to shift patient from their bed , long waiting time and the effect on the hospital cost.

That's why vascular yard aim to practise these doppler ultrasound directly in the patients' room in the bed.

And like that evaluate the patient's satisfaction of this kind of coverage.


Eligibility criteria: Inclusion Criteria:

* hospitalized in vascular yard
* indication of ultrasound doppler
* accept to participate

Exclusion Criteria:

* refuse to participate
* without ultrasound doppler indication.

Primary outcomes:
measure: score of a satisfaction questionnaire
timeFrame: 24 hours
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
affiliation: GHPSJ
name: PRIOLLET Pascal, MD
role: STUDY_DIRECTOR
References:
Clinical trial NCT02072499: KTP Green Light Prostatectomy Compared With Open Prostatectomy
Official title: The Effect of KTP (Potassium-titanyl-phosphate) Green Light Prostatectomy (180W) Compared With Open Prostatectomy When Treating Benign Prostatic Hyperplasia, a Prospective Randomized Study
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE4
Conditions: BPH (Benign Prostatic Hyperplasia)
Lead sponsor: University of Helsinki
Sponsor class: OTHER
First posted: 2014-02-26
Enrollment: 40
Sex: MALE
Minimum age (years): 40
Maximum age (years): 95
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The purpose of this study is to compare safety and efficacy of Green Light PVP (Photoselective Vaporisation of the Prostate) compared to open prostatectomy when treating benign prostatic hyperplasia (BPH).


Eligibility criteria: Inclusion Criteria:

* Men undergoing surgery for BPH with prostate size more than 100cc

Exclusion Criteria:

* Previous prostate surgery
* Carcinoma of the prostate
* Neurogenic bladder
* Bladder carcinoma

Primary outcomes:
measure: IPSS (International Prostate Symptom Score)
timeFrame: 12 months
Secondary outcomes:
measure: DAN-PSS (Danish Prostate Symptom Score)
timeFrame: 0, 3, 6 and 12 months
measure: Maximum flow rate (Qmax)
timeFrame: 0, 3, 6 and 12 months
measure: Residual urine
timeFrame: 0, 3, 6 and 12 months
measure: Length of catheterization
timeFrame: Participants will be followed for the duration of hospital stay, an expected maximum of two weeks
measure: Length of hospital stay
timeFrame: Participants will be followed for the duration of hospital stay, an expected maximum of two weeks
measure: Perioperative bleeding
timeFrame: Time of operation
measure: IIEF (International Index of Erectile Function questionnaire)
timeFrame: 0,12 months
measure: Prostate volume measured with TRUS (transrectal ultrasound)
timeFrame: 0, 12 moths
measure: Rate of unscheduled hospital contacts
timeFrame: 12 months
measure: IPSS (International Prostate Symptom Score)
timeFrame: 0, 3 and 6 months
Other outcomes:
Locations:
city: Helsinki
country: Finland
facility: Helsinki University Hospital
Study officials:
References:
Clinical trial NCT00726999: Perioperative Use of Gabapentin To Decrease Narcotic Requirements in Spinal Fusion
Official title: Perioperative Use of Gabapentin To Decrease Opioid Requirements in Pediatric Spinal Fusion Patients
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Postoperative Pain
Keywords: Gabapentin
Pediatric Spinal Fusion
Narcotic Use
Lead sponsor: Medical College of Wisconsin
Sponsor class: OTHER
Collaborators: name: Children's Hospital and Health System Foundation, Wisconsin
First posted: 2008-08-01
Enrollment: 63
Sex: ALL
Minimum age (years): 9
Maximum age (years): 18
Standard ages: CHILD
ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: Blinded study using oral gabapentin in load pre-operative (15mg/kg) and maintenance 5mg/kg three times a day (TID) for 5 days or discharge, Patient Controlled Analgesia (PCA) morphine and placebo group with similar pills, also PCA morphine. The goal is to measure morphine usage and incidence of morphine side effects (pruritis, days foley, days to first stool, sedation, pain scores, PCA use).

Detailed description: Healthy, American Society of Anesthesia (ASA) 1-2 Idiopathic Scoliosis patients for spinal fusion.

Blinded, drug only known by hospital pharmacist. Study group 1- Gabapentin 15mg/kg with premed, 5/kg TID for 5 days of discharge, standard PCA morphine with dose and basal Study Group 2- Capsules resembling neurontin, with standard PCA morphine

No remifentanil, clonidine, ketamine

N=60 First patient enrolled 6/06 Last patient enrolled 7/15/08

Eligibility criteria: Inclusion Criteria:

* ASA 1-2, Idiopathic Scoliosis

Exclusion Criteria:

* ASA 3 or greater
* Neuromuscular scoliosis
* On narcotics baseline

Primary outcomes:
measure: Amount of Morphine Consumed (mg/kg/hr)
timeFrame: PARU (Postanesthesia Recovery Unit - participants typically remain in PARU for 1 hour)
measure: Amount of Morphine Consumed (mg/kg/hr)
timeFrame: Day 1
measure: Amount of Morphine Consumed (mg/kg/hr)
timeFrame: Day 2
Secondary outcomes:
measure: Number of Ondansetron Doses Administered for Nausea
timeFrame: First 10 days after surgery
Other outcomes:
Locations:
Study officials:
affiliation: Medical College of Wisconsin
name: Lynn M Rusy, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT00587899: Prophylactic Pulmonary Vein Isolation Study
Official title: A Randomized, Single-blind Prophylactic Pulmonary Vein Isolation Procedure Utilizing Bipolar Radiofrequency Ablation in Patients Undergoing Mitral Valve Surgery
Study type: INTERVENTIONAL
Overall status: TERMINATED
Phase: NA
Conditions: Atrial Fibrillation
Keywords: Atrial Fibrillation
AF
A fib
cardiac ablation
modified maze procedure
Lead sponsor: Mayo Clinic
Sponsor class: OTHER
First posted: 2008-01-08
Enrollment: 41
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: PREVENTION

Brief summary: This study is being done to learn the effects of the Pulmonary Vein Isolation in patients that are at high risk to developing, but do not have a documented history of atrial fibrillation.

Detailed description: Patients with a dilated left atrium (left upper chamber of the heart) that undergo mitral valve surgery may be at risk for the development of atrial fibrillation after surgery.

Atrial fibrillation (also known as "A-Fib" or AF) is an abnormal heart rhythm which may cause symptoms such as pounding sensations in your chest, dizziness, fatigue, chest pain and/or shortness of breath. AF patients are at a higher risk of developing a stroke.

Participants who sign informed consent will be randomized into one of two groups by chance (as in the flip of a coin).

Approximately 77 patients will undergo their mitral valve operation along with Pulmonary Vein Isolation (a treatment group) and 77 patients who do not undergo Pulmonary Vein Isolation at the time of their mitral valve surgery (a control group).

The treatment group will undergo operation for mitral valve disease with an additional procedure called Pulmonary Vein Isolation using a device that delivers radiofrequency energy to the heart muscle in order to create scar tissue to block electrical impulses that can trigger episodes of AF.

The control group of patients will undergo operation for mitral valve disease without the additional Pulmonary Vein Isolation.

Eligibility criteria: Inclusion Criteria:

* Indication for open-heart surgery: Mitral valve repair or replacement, evidence of a dilated left atrium

Exclusion Criteria:

* History of Atrial Fibrillation
* Need for emergent cardiac surgery
* Previous cardiac surgery
* Preoperative need for an intraaortic balloon pump or intravenous inotropes
* Current diagnosis of active endocarditis
* Mental impairment/or experience other conditions which may not allow subject to understand nature
* Significance and scope of study
* Pregnancy

Primary outcomes:
measure: Evaluated by the number of patients free of taking antiarrhythmic medications and free of AF as determined by a 24-hour Holter recording.
timeFrame: 12 months
Secondary outcomes:
Other outcomes:
Locations:
city: Rochester
country: United States
facility: Mayo Clinic
state: Minnesota
Study officials:
affiliation: Professor of Surgery, Mayo Clinic
name: Thoralf M. Sundt, III, M.D.
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT02884999: Management of Bleeding and Coagulopathy in Trauma and Compliance to European Trauma Guidelines
Official title: Management of Bleeding and Coagulopathy in Trauma and Compliance to European Trauma Guidelines
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Wounds and Injury
Bleeding
Keywords: trauma
bleeding
coagulopathy
guidelines compliance
recommendation
transfusion
Lead sponsor: University Hospital, Brest
Sponsor class: OTHER
First posted: 2016-08-31
Enrollment: 145
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: RETROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Severe trauma patients

Brief summary: This cohort study describes the epidemiology of trauma patients and their management in a French academic trauma center. It also aims to determine what recommendations from the European trauma guidelines is applied in routine.

Detailed description: Severe trauma is responsible for more than 5 millions of deaths annually worldwide. Haemorrhagic shock secondary to uncontrolled bleeding is the leading cause of preventable death in this population, making bleeding and coagulopathy treatment a key element of the early phase of trauma management. European trauma guidelines have been developed to help clinicians in severe trauma management and improve bleeding and coagulopathy treatment in this population. Investigating who these guidelines are followed in routine is crucial to identify opportunities to improve early management of bleeding severe trauma patients.

Eligibility criteria: Inclusion Criteria:

* Trauma patients with injury severity score equal to or higher than 16 year old admitted to the Brest academic trauma centre within the 24 hours following the trauma

Exclusion Criteria:

Primary outcomes:
measure: Number of patients treated as per studied guidelines
timeFrame: first 24 hours of trauma management
Secondary outcomes:
Other outcomes:
Locations:
city: Brest
country: France
facility: CHRU de BRest
Study officials:
affiliation: CHRU de Brest
name: Cécile Aubron
role: STUDY_DIRECTOR
References:
Clinical trial NCT01638299: Study Assessing an Insulin Pump-controlling Algorithm to Minimize Hypo and Hyper in Type 1 During CRC Setting
Official title: Feasibility Study Assessing the Ability of an Insulin Pump-controlling Algorithm to Minimize Hypoglycemia and Hyperglycemia in Patients With Type 1 Diabetes in a Clinical Research Setting
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE1
Conditions: Type 1 Diabetes Mellitus
Keywords: Type 1 Diabetes Mellitus
Artificial Pancreas
Lead sponsor: Animas Corporation
Sponsor class: INDUSTRY
First posted: 2012-07-11
Enrollment: 20
Sex: ALL
Minimum age (years): 21
Maximum age (years): 65
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: TREATMENT

Brief summary: Feasibility study assessing the ability of an insulin pump-controlling algorithm to minimize hypoglycemia and hyperglycemia in patients with type 1 diabetes in a clinical research setting.

Detailed description: This study is a non-randomized, uncontrolled feasibility study that looks to enroll people with type 1 diabetes who are currently using an insulin pump. During the subject's participation, the study staff will closely monitor the study subject in a clinical research center environment for approximately 30 hours, while controller algorithm determined insulin doses are delivered by an insulin pump, and utilizing continuous glucose monitoring results.

Eligibility criteria: Inclusion Criteria:

* Age 21-65 years
* type 1 diabetes mellitus for at least one year
* Currently using an insulin infusion pump for at least the past 6 months

Exclusion Criteria:

* Pregnancy
* History of Diabetic Ketoacidosis (DKA) in the past six months
* Histoey of severe hypoglycemia (Seizure, unconsciousnesss) in the past 6 months

Primary outcomes:
measure: Evaluation of the performance of the HHM system response to meal insulin while the subject is under close medical supervision in the Clinical Research Center (CRC) setting.
timeFrame: After subject is discharged from CRC, 1 week after enrolment
Secondary outcomes:
measure: Number of Safety Events and any additional information that can be used for product development
timeFrame: After subject is discharged from CRC, 1 week after enrolment
Other outcomes:
Locations:
city: Santa Barbara
country: United States
facility: Samsum Diabetes Reserach Inst.
state: California
city: Charlottesville
country: United States
facility: UVA Diabetes Technology Center
state: Virginia
Study officials:
affiliation: Animas Corporation
name: Henry Anhalt, DO
role: STUDY_DIRECTOR
References:
Clinical trial NCT05308199: Physiotherapy Techniques in Adult Neck Pain
Official title: Comparison of Thoracic Manipulation & MET for Chronic Mechanical Neckache; a Single Blinded Clinical Trail
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Neckache
Keywords: neckache
Lead sponsor: Neuro Counsel Hospital, Pakistan
Sponsor class: OTHER
First posted: 2022-04-01
Enrollment: 30
Sex: ALL
Minimum age (years): 18
Maximum age (years): 60
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Intervention model description: 2 groups , geoup A named as control group and group B named as experimental group
Primary purpose: TREATMENT

Brief summary: To compare the effectiveness of thoracic manipulation and MET on chronic mechanical neckache

Detailed description: it is a randomized control clinical trail to compare the effectiveness of physical exercises for the management of chronical mechanical neckache .so we employed thoracic manipulation for experimental group and MET (muscle energy technique) for control group

Eligibility criteria: Inclusion Criteria:

* Male and female patients with mechanical neck pain having age group of 18 to 60 years.
* Mechanical neck pain having activities of daily living
* Mechanical Neck pain affecting sleep

Exclusion Criteria:

Patients with following conditions will be excluded

* Osteoporosis
* Radiculopathy
* Pregnancy
* Systemic inflammatory condition
* Neurological deficit
* Arthritic conditions
* Head injuries

Primary outcomes:
measure: NPRS
timeFrame: 6 weeks
Secondary outcomes:
measure: frequency of pain
timeFrame: 6 week
Other outcomes:
measure: duration of pain
timeFrame: 6 weeks
Locations:
city: Islamabad
country: Pakistan
facility: Muhammad Salman
state: Fedral
city: Islamabad
country: Pakistan
facility: the Neurocouncil Clinic
state: Fedral
Study officials:
affiliation: the neurocouncil hospital
name: MUHAMMAD SALMAN, M.Phil*
role: PRINCIPAL_INVESTIGATOR
References:
citation: Fejer R, Kyvik KO, Hartvigsen J. The prevalence of neck pain in the world population: a systematic critical review of the literature. Eur Spine J. 2006 Jun;15(6):834-48. doi: 10.1007/s00586-004-0864-4. Epub 2005 Jul 6.
Clinical trial NCT00966199: The Effects of Blood Pressure Reduction on Cerebral Perfusion and Cognition in the Elderly Population
Official title: Medication Induced Blood Pressure Reduction; Assessment of Cerebral Perfusion and Cognition in Hypertensive Elderly
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: PHASE4
Conditions: Hypertension
Keywords: blood pressure
aging
cerebrovascular circulation
hypertension
Lead sponsor: Radboud University Medical Center
Sponsor class: OTHER
Collaborators: name: Dutch Heart Foundation
First posted: 2009-08-26
Enrollment: 60
Sex: ALL
Minimum age (years): 70
Standard ages: OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NON_RANDOMIZED
Intervention model: SINGLE_GROUP
Primary purpose: BASIC_SCIENCE

Brief summary: The purpose of this study is to determine if a reduction in systolic blood pressure induced by anti-hypertensive medication results in changes in cerebral perfusion and cognition in hypertensive elderly. Hypertensive elderly will be treated using open-label anti-hypertensive medication for 8-12 weeks. Changes in cerebral perfusion and cognition will be assessed before and after treatment.


Eligibility criteria: Inclusion Criteria:

* Age \>= 70 years
* Systolic office blood pressure \>= 160 mmHg
* Systolic home blood pressure \>= 155 mmHg

Exclusion Criteria:

* Diabetes Mellitus
* Atrial fibrillation
* Dementia
* Renal failure requiring dialysis
* Life expectancy of less than 1 year
* Disabling stroke
* Contraindication for MRI or anti-hypertensive medication
* Systolic blood pressure \> 220 mmHg

Primary outcomes:
measure: Cerebral blood flow
timeFrame: T1, 8-12 weeks of treatment, T2
Secondary outcomes:
measure: Cognitive functioning assessed by neuropsychological testing
timeFrame: T1, 8-12 weeks of treatment, T2-3
Other outcomes:
Locations:
city: Nijmegen
country: Netherlands
facility: Radboud University
state: Gelderland
Study officials:
affiliation: Radboud University Medical Center
name: Jurgen A Claassen, MD, PhD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT06861699: Blood Flow Technique Effect on the Muscle Mechanics
Official title: Kan Akımı Kısıtlayıcı Egzersizin Kas Mekanikleri Üzerine Akur Etkisi
Study type: OBSERVATIONAL
Overall status: NOT_YET_RECRUITING
Conditions: Biceps
Muscle Rigidity
Lead sponsor: Okan University
Sponsor class: OTHER
First posted: 2025-03-06
Enrollment: 57
Sex: ALL
Minimum age (years): 18
Maximum age (years): 25
Standard ages: ADULT
Accepts healthy volunteers: yes
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: generally college students

Brief summary: This study will be a study in which we take measurements with the myotonPRO device to determine whether the resistant exercises performed without the blood flow restrictive technique and with the blood flow restrictive technique affect the biceps muscle of the participants, who were divided into groups by randomization method after determining the 1 max repetition you can lift.


Eligibility criteria: Inclusion Criteria:

* Being a healthy male or female volunteer between 18 and 35 (who has not participated in any resistance training program for at least 6 months).
* Being right-hand dominant according to the results of the Edinburgh Handedness Inventory.

Exclusion Criteria:

* Having a history of biceps musculoskeletal injury.
* Having any condition that prevents participation in resistance exercise.
* Having cardiovascular disease.
* Using medication for blood pressure control.

Primary outcomes:
measure: muscle mechanics test
timeFrame: Single assessment at baseline and one, two and three days after with measurement
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
References: