Clinical trial NCT06060145: Effect of Indoor Plants on Cardiopulmonary System
Official title: Effect of Indoor Plants on Cardiopulmonary System: a Randomized, Crossover, Controlled Trial
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Cardiopulmonary
Lead sponsor: Zhejiang Chinese Medical University
Sponsor class: OTHER_GOV
Collaborators: name: Zhejiang Chinese Medical University
First posted: 2023-09-29
Enrollment: 41
Sex: ALL
Minimum age (years): 18
Maximum age (years): 35
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: CROSSOVER
Primary purpose: PREVENTION

Brief summary: This is a randomized controlled human exposure crossover study, aims to explore the health benefits of indoor plants on cardiopulmonary system on adults.

Detailed description: The researchers will conduct a randomized cross-controlled trial involving 48 healthy adults in Hangzhou, China. These participants will be randomly assigned into two groups, each comprising 24 individuals. Each participant will undergo two separate exposures in an office setting: one exposure without any plants present, and another exposure with 34 to 38 potted plants. A washout period of at least 4 weeks will be implemented between the two exposures. Questionnaires, physical examinations and the collection of biological samples will be conducted prior to exposure and after exposure. In addition, the monitoring of negative air ion, air pollutants and noise exposure, as well as collection of environmental microbial samples, will be conducted on weekdays. Researchers will gather samples of blood, urine, nasal secretion, and exhaled breath condensate from participants.

Eligibility criteria: Inclusion Criteria:

* Living in Hangzhou during the study period;
* Non-smoking, no history of alcohol or drug abuse;
* Staying indoors in daytime we required.

Exclusion Criteria:

* Current or ever smokers;
* Subjects with allergic disease, such as allergic rhinitis, allergic asthma, and atopy;
* Subjects with cardiovascular disease, such as congenital heart disease, pulmonary heart disease, and hypertension;
* Subjects with respiratory disease, such as asthma, chronic bronchitis, and chronic obstructive pulmonary disease;
* Subjects with chronic disease, such as diabetes, chronic hepatitis, and kidney disease;
* Subjects with a history of major surgery;
* Medication use or dietary supplements intake in recent two months;
* Unable to cooperate with follow-up.

Primary outcomes:
measure: Forced Vital Capacity(FVC)
timeFrame: Baseline and after 4 weeks plants exposure in first stage, and after washout period, baseline and after 4 weeks plants exposure in second stage.
Secondary outcomes:
measure: Blood Pressure(BP)
timeFrame: Baseline and after 4 weeks plants exposure in first stage, and after washout period, baseline and after 4 weeks plants exposure in second stage.
measure: Heart Rate Variability(HRV)
timeFrame: Baseline and after 4 weeks plants exposure in first stage, and after washout period, baseline and after 4 weeks plants exposure in second stage.
Other outcomes:
measure: C-reactive protein(CRP)
timeFrame: Baseline and after 4 weeks plants exposure in first stage, and after washout period, baseline and after 4 weeks plants exposure in second stage.
measure: Interleukin-6(IL-6)
timeFrame: Baseline and after 4 weeks plants exposure in first stage, and after washout period, baseline and after 4 weeks plants exposure in second stage.
measure: Tumor necrosis factor-α(TNF-α)
timeFrame: Time Frame: Baseline and after 4 weeks plants exposure in first stage, and after washout period, baseline and after 4 weeks plants exposure in second stage.
Locations:
city: Huangzhou
country: China
facility: Zhejiang Chinese Medicine University
state: Zhejiang
Study officials:
affiliation: School of Public Health, Zhejiang Chinese Medical University
name: Lina Zhang, Ph.D
role: PRINCIPAL_INVESTIGATOR
References: