louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT00580541: Effect of Liking on Fruit Intake
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Intake of Fruit
Lead sponsor: The Miriam Hospital
Sponsor class: OTHER
First posted: 2007-12-24
Enrollment: 20
Sex: ALL
Minimum age (years): 18
Maximum age (years): 45
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: CROSSOVER

Brief summary: Increased dietary variety has been shown to increase intake in animals, as well as humans, as compared to a diet or meal composed of one food. While most studies investigating dietary variety have focused on energy-dense foods (i.e., snack foods) and have emphasized the negative component that variety has on intake, very little research has been conducted with variety to determine if this food characteristic can be used to increase consumption of healthy foods (i.e., fruits). We hypothesize that increasing variety of fruits provided in an eating bout will lead to increased intake of these foods. Therefore, the aim of this investigation is to test the environmental factor of variety on fruit intake in males and females aged 18 to 45 years.


Eligibility criteria: Inclusion Criteria:

* Non-smoking
* Non-obese
* Unrestrained males and females

Exclusion Criteria:

* Health condition or use medications that influence food intake
* Require specialized diet therapy
* Following a weight loss diet, an athlete, or pregnant or breastfeeding
* Have allergies or aversions to foods used in study
* Report being a binge eater

Primary outcomes:
measure: fruit intake
timeFrame: 5 weeks
Secondary outcomes:
Other outcomes:
Locations:
city: Providence
country: United States
facility: Weight Control and Diabetes Research Center
state: Rhode Island
Study officials:
affiliation: University of Tennessee
name: Hollie Raynor, PhD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT06323941: Motor Imagery and Isometric Exercises on Pelvic Floor Sensorimotor Condition
Official title: Effects of Motor Imagery on Skin Conductance and Pelvic Floor Sensorimotor Condition in Healthy Women: A Randomized Controlled Trial
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Isometric Exercise
Motor Imagery
Women's Health
Lead sponsor: University of Valencia
Sponsor class: OTHER
First posted: 2024-03-21
Enrollment: 30
Sex: FEMALE
Minimum age (years): 18
Maximum age (years): 30
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: Mental practice (both in isolation and also in combination with real practice) has been shown to improve somatosensory and motor variables but so far no study has taken it into the study of women's health. Through the present study the investigators want to offer some interesting data regarding the effectiveness of mental practice combined with physical practice.


Eligibility criteria: Inclusion Criteria:

* Over 18 years of age and asymptomatic women.

Exclusion Criteria:

* This study will exclude those who presented a respiratory pathology, cardiac, systematic, or metabolic disease, history of recent surgery, vertebral fracture, or osteoarticular disorders of the spine area.

Primary outcomes:
measure: Skin conductance (for asessing electrodermal activity)
timeFrame: pre-intervention (T0), and inmmediate post-intervention (T1) (between the first and the second measurement, about 60 minutes have elapsed because it is done on the same day)
Secondary outcomes:
measure: Algometry for assessing pressure pain thresholds (Pain sensitivity)
timeFrame: pre-intervention (T0), and inmmediate post-intervention (T1) (between the first and the second measurement, about 60 minutes have elapsed because it is done on the same day)
measure: maximal pelvic floor muscle strength (measured in grams and with the phenix device)
timeFrame: pre-intervention (T0), and inmmediate post-intervention (T1) (between the first and the second measurement, about 60 minutes have elapsed because it is done on the same day)
Other outcomes:
Locations:
city: Valencia
country: Spain
facility: Ferran Cuenca Martínez
Study officials:
References:
Clinical trial NCT06369441: Collection of Biological Specimens and Associated Health Information
Official title: Collection of Biological Specimens and Associated Health Information for Secondary Research in Future Studies
Study type: OBSERVATIONAL
Overall status: NOT_YET_RECRUITING
Conditions: Cancer
Other Disease
Lead sponsor: Ovation.io, Inc.
Sponsor class: INDUSTRY
First posted: 2024-04-17
Enrollment: 10000
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: CASE_ONLY
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Adults who have an active cancer diagnosis with confirmatory pathology results indicating solid tumor and/or hematologic malignancy

Brief summary: The purpose of this study is to collect blood samples from a large number of individuals with cancer to create a database for researchers to use in future studies. Researchers may use this database to discover new ways to detect and treat cancer and other diseases. Future studies may use stored blood samples to discover how genes affect health and disease.


Eligibility criteria: Inclusion Criteria:

* Are patients of participating study site clinics/clinical groups
* Are adults (aged 18 or older)
* Have an active cancer diagnosis with confirmatory pathology results indicating solid tumor and/or hematologic malignancy
* Participants may have other active diagnoses with confirmatory clinical results

Exclusion Criteria:

* Individuals who lack the capacity to provide informed consent
* Individuals known to be prisoners at time of biological specimen collection

Primary outcomes:
measure: Biorepository
timeFrame: 10 years
Secondary outcomes:
Other outcomes:
Locations:
city: Portland
country: United States
facility: Ovation.io
state: Maine
Study officials:
affiliation: VP, Clinical Affairs, Ovation.io
name: Pauline Gee, PhD
role: STUDY_DIRECTOR
References:
Clinical trial NCT00152841: Effect of Iron and Vitamin E Supplementation on Disease Activity in Patients With Either Crohn's Disease or Ulcerative Colitis
Official title: Effect of Iron and Antioxidant Vitamins on Disease Activity and Oxidative Stress in Inflammatory Bowel Disease (IBD)
Study type: INTERVENTIONAL
Overall status: TERMINATED
Phase: PHASE2
Conditions: Crohn's Disease
Ulcerative Colitis
Mild or Moderate Anaemia
Lead sponsor: University Health Network, Toronto
Sponsor class: OTHER
Collaborators: name: Crohn's and Colitis Foundation
First posted: 2005-09-09
Enrollment: 30
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: CROSSOVER

Brief summary: Hypothesis:In patients with ulcerative colitis and Crohn's disease diagnosed with mild or moderate anaemia:

1. iron supplementation will increase disease activity and oxidative stress
2. the addition of antioxidant vitamin will reduce this detrimental effect

Detailed description: To maintain site/extent of disease and medication consistent among groups, the design is a double blind crossover placebo-controlled trial.

1. If mild anaemia, patients are randomized to 300 mg of ferrous fumarate or placebo for 4 weeks followed by 2 weeks of washout period after which patients will crossover the opposite treatments for another 4 weeks.
2. If moderate anaemia, patients will receive 600 mg of ferrous fumarate for 10 weeks. They are randomized to either vitamin E (800 IU) or placebo for 4 weeks followed by 2 weeks of washout period after which patients will crossover the opposite treatments for another 4 weeks

Eligibility criteria: Inclusion Criteria:

* \> 18 years old
* diagnosed with inflammatory Bowel Disease (ulcerative colitis and Crohn's disease)
* with mild or moderate anaemia

Exclusion Criteria:

* not diagnosed with bowel obstruction
* not diagnosed with short bowel syndrome
* not taking iron supplement or antioxidant vitamins and minerals

Primary outcomes:
measure: calprotectin in stools at baseline, week 4, week 6, week 10
Secondary outcomes:
measure: disease activity index
measure: oxidative stress (plasma lipid peroxides, antioxidant potency, vitamin C, vitamin E, superoxide dismutase)
measure: blood measurement of CBD
measure: iron status
Other outcomes:
Locations:
city: Toronto
country: Canada
facility: University Health Network - Toronto General Hospital
state: Ontario
Study officials:
affiliation: University Health Network - Toronto General Hospital
name: Allard Johane, MD, FRCPC
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT00843141: The Efficacy of Computerized Cognitive Training in Adults With ADHD: Change in ADHD Symptoms, Executive Functions and Quality of Life Following Three Months of Training.
Official title: ADHD Symptoms, Executive Functions and Quality of Life Following Three Months of Training.
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Attention Deficit Hyperactivity Disorder
Keywords: ADHD
Executive functions
Quality of life
Lead sponsor: Hadassah Medical Organization
Sponsor class: OTHER
First posted: 2009-02-13
Enrollment: 60
Sex: ALL
Minimum age (years): 18
Maximum age (years): 60
Standard ages: ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The study group of Adults with ADHD who will receive cognitive (executive attention) computerized training will show significant improvement in ADHD symptomatology,neuropsychological measures,daily functioning and quality of life.

A significant difference will be found between the study group and the control group (adults with ADHD that will receive a simplified cognitive training program that does not challenge their executive functions)on the above measures.


Eligibility criteria: Inclusion Criteria:

* Adults (age 18-60);
* 9 years education;
* Diagnosis of ADHD;
* Executive function deficit in daily life;
* Signed informed consent.

Exclusion Criteria:

* Change in pharmacological treatment and/or received new treatment for ADHD in the last three months;
* Other current serious neurological disorder (e.g. epilepsy, brain injury, neurodegenerative disease), other major current and sever psychiatric disorder (axisI);
* Color blindness.

Primary outcomes:
measure: Executive functioning
timeFrame: after 3 months of cognitive training
Secondary outcomes:
measure: ADHD symptomatology and quality of life
timeFrame: after 3 months of cognitive training
Other outcomes:
Locations:
city: Jerusalem
country: Israel
facility: Hadassah Medical Organization
Study officials:
affiliation: Hadassah Medical Organization
name: Omer Bonne, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT02738541: Anti-calculus Efficacy of a Dentrifice Containing Sodium Pyrophosphate and Potassium Pyrophosphate in Heavy Calculus Formers
Official title: Evaluation of Anti-calculus Efficacy of a Dentrifice Containing Sodium Pyrophosphate and Potassium Pyrophosphate in Heavy Calculus Formers
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE2
Conditions: ANTICALCULUS EFFICACY OF PYROPHOSPHATE IN HEAVY CALCULUS FORMERS
Lead sponsor: Government Dental College and Research Institute, Bangalore
Sponsor class: OTHER
First posted: 2016-04-14
Enrollment: 60
Sex: ALL
Minimum age (years): 15
Maximum age (years): 30
Standard ages: CHILD
ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The purpose of this study was to determine the anti-calculus effect of dentrifice containing 5% sodium pyrophosphate and potassium pyrophosphate in a triple-mask placebo controlled randomized clinical trial.


Eligibility criteria: Inclusion Criteria:

1. Age group 15-30 years.
2. Subjects who have not received periodontal therapy within preceding 1year.
3. Heavy calculus formers with simplified calculus index score 1.5-3 .

Exclusion Criteria:

1. Age group 15-30 years.
2. Subjects who have not received periodontal therapy within preceding 1year.
3. Heavy calculus formers with simplified calculus index score 1.5-3 .

Primary outcomes:
measure: simplied calulus index.
timeFrame: Baseline to 6 months
Secondary outcomes:
Other outcomes:
Locations:
city: Bangalore
country: India
facility: Government Dental College and Research Institute
state: Karnataka
Study officials:
References:
Clinical trial NCT03742141: Intraoperative Video Laryngoscopy as Adjunct for Nerve Monitoring
Official title: Intraoperative Video Laryngoscopy as Adjunct for Nerve Monitoring
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Vocal Cord Function in Neck Procedures
Keywords: Thyroidectomy
Neck Procedures
Nerve Monitoring
Lead sponsor: Icahn School of Medicine at Mount Sinai
Sponsor class: OTHER
Collaborators: name: NeuroVision
First posted: 2018-11-15
Enrollment: 125
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Intervention model description: All patients enrolled in the study will be in a single group.
Primary purpose: OTHER

Brief summary: The purpose of this study is to describe the impact of adding intraoperative video laryngoscopy (IOVL) to intraoperative laryngeal nerve monitoring (IOLNM) during neck procedures when IOLNM is routinely used, including thyroidectomy and re-operative parathyroidectomy. Specifically, the study team seeks to assess how frequently the use of IOVL provided confirmatory or additional information that may affect surgeon decision-making when IOLNM alone is ambiguous, or when there is equipment malfunction or failure. The IOVL is a disposable, otherwise standard fiberoptic laryngoscope (Larynxview, Neurovision Medical, Ventura CA) that is inserted alongside the endotracheal tube following intubation for surgical procedures. It allows assessment of vocal cord movement in response to nerve stimulation. Currently, the use of IOLNM is based on audio cues, and visual assessment of external laryngeal muscle movement during surgery in response to stimulation, but no direct assessment of vocal cord movement is routinely possible. This information can be ambiguous and subject to judgement of the surgeon. The addition of IOVL provides direct assessment to vocal cord movement in response to stimulus, and may be useful in light of ambiguous IOLNM data, or limited visualization of external laryngeal muscles.


Eligibility criteria: Inclusion Criteria:

* Age 18 and older with capacity to make all medical decisions
* Medical indication for partial or total thyroidectomy, re-operative parathyroidectomy, or neck dissection

Exclusion Criteria:

* Patients who are under the age of 18
* Patients who are not able to make medical decisions or consent to research

Primary outcomes:
measure: Frequency of Congruence of Nerve Integrity and Vocal Cord Functions
timeFrame: up to 3 months post-resection
Secondary outcomes:
Other outcomes:
Locations:
city: Long Island City
country: United States
facility: Mount Sinai Queens
state: New York
city: New York
country: United States
facility: Mount Sinai Beth Israel
state: New York
city: New York
country: United States
facility: Mount Sinai West
state: New York
city: New York
country: United States
facility: Mount Sinai St. Luke's
state: New York
city: New York
country: United States
facility: The Mount Sinai Hospital
state: New York
Study officials:
affiliation: Icahn School of Medicine at Mount Sinai
name: Randall Owen, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT05446441: Endoscopic Thyroidectomy Versus Open Thyroidectomy for Papillary Thyroid Carcinoma
Official title: Endoscopic Thyroidectomy Using Gasless Unilateral Transaxillary Approach Versus Conventional Open Thyroidectomy for Papillary Thyroid Cancer: a Prospective, Multicenter, Randomized Controlled Clinical Trial
Study type: INTERVENTIONAL
Overall status: NOT_YET_RECRUITING
Phase: NA
Conditions: Thyroid Cancer
Keywords: Thyroid Cancer
Endoscopic surgery
Open surgery
Radical thyroidectomy
Lead sponsor: Zhejiang Provincial People's Hospital
Sponsor class: OTHER
First posted: 2022-07-06
Enrollment: 634
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: Recently, endoscopic thyroidectomy using gasless unilateral transaxillary approach has been proven feasible and safe in several Chinese medical centers. This study is aimed to compare multi-institutional Chinese outcomes of endoscopic thyroidectomy using gasless unilateral transaxillary approach and conventional open surgery.

Detailed description: Most patients with thyroid tumors are effectively treated surgically by practitioners experienced in the techniques of thyroidectomy. Many patients, especially women, undergoing thyroid surgery are concerned about the postoperative cosmetic appearance of the neck. Endoscopic thyroidectomy using gasless unilateral transaxillary approach which can hide the operative scar was associated with a higher degree of patient cosmetic satisfaction. Recently, endoscopic thyroidectomy using gasless unilateral transaxillary approach has been proven feasible and safe in several Chinese medical centers. In this study, we designed a prospective study comparing multi-institutional Chinese outcomes of endoscopic thyroidectomy using gasless unilateral transaxillary approach and conventional open surgery.

Eligibility criteria: Inclusion Criteria:

* Age ≥ 18 years;
* The pathological type is papillary thyroid carcinoma;
* Tumor diameter \<2 cm；
* No extraglandular invasion, or minimal extrathyroidal extension invading only anterior thyroid capsule or sternothyoid muscle；
* cN0 or cN+ without fusion and fixation of metastatic lymph nodes；
* no obvious contraindication for thyroidectomy ;
* Good comply with the research visit plan and other program requirements;
* Ability to understand and the willingness to sign a written informed consent document.

Exclusion Criteria:

* patients with severe systemic diseases who can not tolerate general anesthesia or routine surgical posture;
* previous history of neck surgery, radiotherapy or thermal ablation;
* hyperthyroidism and substernal goiter;
* dedifferentiated thyroid carcinoma；
* accompanied with severe thyroiditis.

Primary outcomes:
measure: Number of retrieved central lymph nodes
timeFrame: 1 month after operation
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
affiliation: Zhejiang Provincial People's Hospital
name: Minghua Ge, Doctor
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT03002441: Same-day Cervical Preparation Before Dilation and Evacuation
Official title: Same-day Cervical Preparation With Dilapan-S™ Plus Buccal Misoprostol Compared to Overnight Dilapan-S™ Before Dilation and Evacuation at 16 to 20 Weeks' Gestation: A Randomized Controlled Trial
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Cervical Dilation Prior to Dilation and Evacuation
Lead sponsor: Planned Parenthood of Greater New York
Sponsor class: OTHER
First posted: 2016-12-23
Enrollment: 54
Sex: FEMALE
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The purpose of this randomized trial is to compare same-day cervical preparation using Dilapan-S™ plus buccal misoprostol to overnight cervical preparation using Dilapan-S™ before D\&E at 16.0 to 20.0 weeks.

Primary objective: To compare D\&E operative time. We hypothesize that same-day Dilapan-S™ plus buccal misoprostol is non-inferior to overnight Dilapan-S™ with respect to operative time.

Secondary objectives: To compare treatment groups for the following: Pre-operative cervical dilation; need for mechanical dilation and ease of dilation if required; ability to complete D\&E without further cervical preparation; ease of D\&E; complications; pain; side effects; patient and provider satisfaction.


Eligibility criteria: Inclusion Criteria:

* 18 years of age and older
* Seeking pregnancy termination from 16 0/7 to 19 6/7 weeks of gestation on the day of enrollment.
* Eligible for pregnancy termination at PPNYC
* Able to give informed consent
* English speaking

Exclusion Criteria:

* Active bleeding or hemodynamically unstable at enrollment
* Signs of chorioamnionitis or clinical infection at enrollment
* Signs of spontaneous labor or cervical insufficiency at enrollment
* Spontaneous intrauterine fetal demise
* Allergy to Dilapan-S™ or misoprostol

Primary outcomes:
measure: Operative time
timeFrame: From initiation of D&E procedure to completion of D&E procedure, Study Day 2
Secondary outcomes:
Other outcomes:
Locations:
city: New York
country: United States
facility: Planned Parenthood of Greater New York
state: New York
Study officials:
affiliation: Planned Parenthood of Greater New York
name: Ila Dayananda
role: PRINCIPAL_INVESTIGATOR
References:
citation: Kim CS, Dragoman M, Porsch L, Markowitz J, Lunde B, Stoffels G, Dayananda I. Same-Day Compared With Overnight Cervical Preparation Before Dilation and Evacuation Between 16 and 19 6/7 Weeks of Gestation: A Randomized Controlled Trial. Obstet Gynecol. 2022 Jun 1;139(6):1141-1144. doi: 10.1097/AOG.0000000000004790. Epub 2022 May 2.
Clinical trial NCT04156841: Sentinel Lymph Node Biopsy in Early Breast Cancer: a Real-world Multicenter Cross-sectional Study (CABS001 Study)
Official title: Sentinel Lymph Node Biopsy in Early Breast Cancer: a Real-world Multicenter Cross-sectional Study (CABS001 Study)
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Breast Cancer
Sentinel Lymph Node
Lead sponsor: Xijing Hospital
Sponsor class: OTHER
First posted: 2019-11-08
Enrollment: 21000
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: RETROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: early breast cancer patients who underwent SLNB in 40 Grade III Level A hospitals in China in 2018

Brief summary: Objective: To investigate the current clinical practice of sentinel lymph node biopsy (SLNB) in patients with early stage breast cancer in China. Methods: The data of early breast cancer patients who underwent SLNB in 40 Grade III Level A hospitals in China in 2018 will be collected. Different centers, tracer methods, molecular typing and neoadjuvant chemotherapy will be used as stratification factors to analyze the implementation rate, number of detections, positive rate of SLNB and the follow-up treatment.


Eligibility criteria: Inclusion Criteria:

* breast cancer confirmed by fine needle aspiration or biopsy
* SLNB with or without axillary lymph node dissection
* receiving conventional systematic treatment or regional treatment
* complete medical record.

Exclusion Criteria:

* IV stage breast cancer
* combined with secondary invasive malignant tumor
* diagnosed with other serious disease, including congestive heart failure (NYHA cardiac function grade II, III, IV) or congestive heart failure, unstable angina pectoris, myocardial infarction, high-risk uncontrollable heart rate disorder or other serious cardiovascular diseases within 6 months
* difficulty breathing at rest or need oxygen therapy
* severe infection
* uncontrolled diabetes
* serious psychological or mental disorders
* poor compliance.

Primary outcomes:
measure: the performance rate of sentinel lymph node biopsy (SLNB) in patients with early stage breast cancer in China
timeFrame: 2020-12-31
measure: the positive rate of SLNs in patients with early stage breast cancer in China
timeFrame: 2020-12-31
measure: the number of resected SLNs in patients with early stage breast cancer in China
timeFrame: 2020-12-31
Secondary outcomes:
measure: incidence of infection events after SLNB in patients with early stage breast cancer in China
timeFrame: 2021-12-31
Other outcomes:
Locations:
city: Xi'an
country: China
facility: Xijing hospital
state: Shaanxi
Study officials:
References: