Clinical trial NCT06257719: Clinical Characteristics of Lymphatic Malformations
Official title: Clinical Characteristics of Lymphatic Malformations: An Observational Study
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Lymphatic Malformation
Lymphangioma
Keywords: Lymphatic Malformation
Abdominal site
Preoperative complications
Resection
Mesentery
Acute abdomen
Lead sponsor: West China Hospital
Sponsor class: OTHER
First posted: 2024-02-14
Enrollment: 320
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Observational model: COHORT
Time perspective: RETROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: In this study, The investigators retrospectively collected and compared the data related to the preoperative information, intraoperative findings and postoperative pathological analysis of the enrolled abdominal lymphatic malformations for paediatric and adult participants.

Brief summary: The primary purpose of this study is to retrospectively identify the clinical characteristics of abdominal lymphatic malformations (ALMs) in our single center in China. The second objective of this study is to retrospectively compare the epidemiological features, clinical presentations, cyst properties, surgical treatments, and risk factors for preoperative complications of ALMs between paediatric participants and adult participants.

Detailed description: Lymphatic malformations (LMs) are vascular anomalies that arise from abnormal embryonic development of the lymphatic system and can present as dilated lymphatic channels or cysts lined by lymphatic endothelial cells. Abdominal lymphatic malformations (ALMs) are rare entities that account for fewer than 10% of LMs and may occur not only in the tissues or organs in the abdominal cavity, such as the mesentery, spleen and pancreas but also in the retroperitoneal space. ALMs can manifest as an infection, chronic abdominal discomfort, acute abdomen, or fatal disease.

Eligibility criteria: Inclusion Criteria:

* The investigators enrolled participants who were pathologically diagnosed with lymphangioma or lymphatic malformations in the abdominal cavity (i.e., abdominal lymphatic malformations) from January 2009 to December 2022 at our institution.

Exclusion Criteria:

* The investigators excluded participants without a pathological diagnosis of abdominal lymphatic malformations through resection specimens and those with pathological confirmation of other diseases, as well as patients with complex lymphatic anomalies.

Primary outcomes:
measure: The location of abdominal lymphatic malformations in participants
timeFrame: From 2009.1 to 2022.12
measure: The morphologic subtypes of abdominal lymphatic malformations in participants
timeFrame: From 2009.1 to 2022.12
measure: The presentations at diagnosis of abdominal lymphatic malformations in participants
timeFrame: From 2009.1 to 2022.12
measure: The largest diameter of abdominal lymphatic malformations in participants
timeFrame: From 2009.1 to 2022.12
measure: The preoperative complications of abdominal lymphatic malformations in participants
timeFrame: From 2009.1 to 2022.12
Secondary outcomes:
measure: The incidence of abdominal lymphatic malformations in paediatric and adult group
timeFrame: From 2009.1 to 2022.12
measure: The number of female patients with abdominal lymphatic malformations in paediatric and adult group
timeFrame: From 2009.1 to 2022.12
measure: The rate of abdominal lymphatic malformations with acute abdomen in paediatric and adult group
timeFrame: From 2009.1 to 2022.12
measure: The rate of abdominal lymphatic malformations located in mesentery for paediatric and adult group
timeFrame: From 2009.1 to 2022.12
measure: The risk factors of preoperative complications of abdominal lymphatic malformations for paediatric and adult group.
timeFrame: From 2009.1 to 2022.12
Other outcomes:
Locations:
city: Chengdu
country: China
facility: West China Hospital of Sichuan University
state: Sichuan
Study officials:
affiliation: West China Hospital
name: Yi Ji, Ph.D.
role: PRINCIPAL_INVESTIGATOR
References: