Clinical trial NCT01214954: Early Rehabilitation After Total Hip Replacement
Official title: Early Rehabilitation After Toal Hip Replacement. -Effect of Supervised Progressive Resistance Training
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Osteoarthritis, Hip
Keywords: Total Hip Replacement
Rehabilitation
Resistance training
Lead sponsor: University of Aarhus
Sponsor class: OTHER
Collaborators: name: Regionshospitalet Silkeborg
First posted: 2010-10-05
Enrollment: 73
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The purpose of this study is to determine whether supervised progressive resistance training is effective in the early phase after Total Hip Replacement. The investigators hypothesise that 10 weeks of supervised, progressive resistance training immediately after discharge will lead to increased functional performance, muscle strength and muscle power compared to standard rehabilitation consisting of home-based exercise.

Detailed description: After total hip replacement (THR) surgery there is a documented deficit in muscle strength and functional performance. There is a lack of evidence concerning the effectiveness of postoperative physiotherapy and training, however a few small studies have shown promising effect of resistance training.

The present study will provide new and important knowledge concerning the effect of different rehabilitation strategies after THR. This might lead to a change in the rehabilitation regimes and faster and better recovery after THR surgery.

Eligibility criteria: Inclusion Criteria:

* Total hip replacement for osteoarthrosis
* Living within 30 km from the hospital
* Motivated to attend training 2 times/week in 10 weeks
* Reduced functional ability measured as: HOOS score \< 67
* written informed consent

Exclusion Criteria:

* Comorbidities such as cancer, neuromuscular diseases, heart diseases etc.
* Cognitive impairment
* Body mass index \> 35
* Resurfacing prosthesis
* Scheduled additional prosthetic surgery in lower extremity within 6 months

Primary outcomes:
measure: Leg extension power
timeFrame: 10 weeks postoperative
Secondary outcomes:
measure: Walking speed
timeFrame: 4 weeks postoperative
measure: Sit-to-stand
timeFrame: 10 weeks postoperative
measure: Stair test
timeFrame: 10 weeks postoperative
measure: Hip Osteoarthritis Outcome Score (HOOS)
timeFrame: 6 months postoperative
measure: Walking speed
timeFrame: 10 weeks
measure: Walking speed
timeFrame: 6 months postoperative
measure: Leg extension power
timeFrame: 6 months postoperative
measure: Sit-to-stand
timeFrame: 6 months postoperative
measure: Stair test
timeFrame: 6 months postoperative
measure: Hip Osteoarthritis Outcome Score (HOOS)
timeFrame: 2 weeks postoperative
measure: Hip Osteoarthritis Outcome Score (HOOS)
timeFrame: 4 weeks postoperative
measure: Hip Osteoarthritis Outcome Score (HOOS)
timeFrame: 6 weeks postoperative
measure: Isometric muscle strength
timeFrame: 4 weeks postoperative
measure: Isometric muscle strength
timeFrame: 10 weeks postoperative
measure: Isometric muscle strength
timeFrame: 6 months postoperative
measure: Gait quality
timeFrame: 10 weeks postoperative
measure: Gait quality
timeFrame: 6 months postoperative
measure: Hip Osteoarthritis Outcome Score (HOOS)
timeFrame: 10 weeks postoperative
measure: Hip Osteoarthritis Outcome Score (HOOS)
timeFrame: 1 year postoperative
Other outcomes:
Locations:
city: Silkeborg
country: Denmark
facility: Silkeborg Regional Hospital
Study officials:
affiliation: University of Aarhus
name: Lone R Mikkelsen, MSc.
role: PRINCIPAL_INVESTIGATOR
References:
citation: Mikkelsen LR, Petersen AK, Mechlenburg I, Mikkelsen S, Soballe K, Bandholm T. Description of load progression and pain response during progressive resistance training early after total hip arthroplasty: secondary analyses from a randomized controlled trial. Clin Rehabil. 2017 Jan;31(1):11-22. doi: 10.1177/0269215516628305. Epub 2016 Jul 10.
citation: Mikkelsen LR, Mechlenburg I, Soballe K, Jorgensen LB, Mikkelsen S, Bandholm T, Petersen AK. Effect of early supervised progressive resistance training compared to unsupervised home-based exercise after fast-track total hip replacement applied to patients with preoperative functional limitations. A single-blinded randomised controlled trial. Osteoarthritis Cartilage. 2014 Dec;22(12):2051-8. doi: 10.1016/j.joca.2014.09.025. Epub 2014 Oct 22.