Clinical trial NCT02915913: Effects of Exercise Training on Cognitive Function and Neurotrophic Factors in Overweight Adults
Official title: Effects of High Intensity Interval- vs Resistance or Combined- Training for Improving Cognitive Function and Neurotrophic Factors in Overweight Adults (BrainFit Study): Factorial Randomised Controlled Trial
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Cognitive Function
Motor Activity
Obesity
Lead sponsor: Universidad Santo Tomas
Sponsor class: OTHER
Collaborators: name: Universidad del Rosario
name: Universidad Nacional de Colombia
First posted: 2016-09-27
Enrollment: 60
Sex: MALE
Minimum age (years): 18
Maximum age (years): 30
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: FACTORIAL
Primary purpose: PREVENTION

Brief summary: The BrainFit Study aims to examine acute effects of High Intensity Interval- vs Resistance or Combined program has benefits on Cognitive Function as well as on secretion and regulation of neurotrophic factors or neurotrophins in a cohort of sedentary, overweight adults (aged 18-30 years) from Bogota, Colombia.


Eligibility criteria: Inclusion Criteria:

* Written informed consent.
* Interested in improving health and fitness.
* Central obesity: waist circumference ≥90cm
* Body mass index ≥ 26 kg/m(2)

Exclusion Criteria:

* Systemic infections.
* Weight loss or gain of \>10% of body weight in the past 6 months for any reason.
* Currently taking medication that suppresses or stimulates appetite.
* Uncontrolled hypertension: systolic blood pressure 160 mm Hg or diastolic blood pressure 95 mm Hg on treatment.
* Gastrointestinal disease, including self-reported chronic hepatitis or cirrhosis, any episode of alcoholic hepatitis or alcoholic pancreatitis within past year, inflammatory bowel disease requiring treatment in the past year, recent or significant abdominal surgery (e.g., gastrectomy).
* Asthma.
* Diagnosed diabetes (type 1 or 2), fasting impaired glucose tolerance (blood glucose 118 mg/dL), or use of any anti-diabetic medications.
* Currently taking antidepressant, steroid, or thyroid medication, unless dosage is stable (no change for 6 months).
* Any active use of illegal or illicit drugs.
* Current exerciser (\>30 min organized exercise per week).
* Indication of unsuitability of current health for exercise protocol (PARQ).

Primary outcomes:
measure: Change from Baseline in Brain-derived neurotrophic factor
timeFrame: Baseline and 60 minutes immediately after the interventions ends
Secondary outcomes:
measure: Change from Baseline in Neurotrophin-3
timeFrame: Baseline and 60 minutes immediately after the interventions ends
measure: Change from Baseline in Neurotrophin-4
timeFrame: Baseline and 60 minutes immediately after the interventions ends
measure: Change from Baseline change in Cognitive Function
timeFrame: Baseline and 60 minutes immediately after the interventions ends
Other outcomes:
Locations:
city: Bogota
country: Colombia
facility: Robinson Ramírez-Vélez
state: Cundinamarca
Study officials:
affiliation: Universidad del Rosario
name: Robinson Ramírez-Vélez, Ph.D
role: STUDY_DIRECTOR
References:
citation: Dominguez-Sanchez MA, Bustos-Cruz RH, Velasco-Orjuela GP, Quintero AP, Tordecilla-Sanders A, Correa-Bautista JE, Triana-Reina HR, Garcia-Hermoso A, Gonzalez-Ruiz K, Pena-Guzman CA, Hernandez E, Pena-Ibagon JC, Tellez-T LA, Izquierdo M, Ramirez-Velez R. Acute Effects of High Intensity, Resistance, or Combined Protocol on the Increase of Level of Neurotrophic Factors in Physically Inactive Overweight Adults: The BrainFit Study. Front Physiol. 2018 Jun 27;9:741. doi: 10.3389/fphys.2018.00741. eCollection 2018.