louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT01150006: Correlation Between Various Adipokines and Vascular Inflammation Measured by Positron Emission Tomography (PET) With 18F-fluoro-deoxyglucose (FDG) (18FDG-PET)
Official title: Correlation Between Various Adipokines and Vascular Inflammation Measured by 18FDG-PET In Healthy Male Subjects
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Atherosclerosis
Keywords: atherosclerosis
vascular inflammation
adipocyte fatty acid binding protein
adiponectin
leptin
18FDG-PET
Lead sponsor: Korea University
Sponsor class: OTHER
First posted: 2010-06-24
Enrollment: 90
Sex: MALE
Minimum age (years): 20
Maximum age (years): 80
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: CASE_ONLY
Time perspective: CROSS_SECTIONAL
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Healthy male participats who underwent a medical health check in the health promotion center in Korea Guro University

Brief summary: The inflammatory state and composition of atherosclerotic plaques are considered the main contributing factors responsible for acute cardiovascular events, rather than the degree of stenosis. Recently, positron emission tomography (PET) with 18F-fluoro-deoxyglucose (FDG) has been suggested as a promising novel imaging technique to identify the inflammatory state of atherosclerotic plaque. Recently, a few clinical studies showed that circulating A-FABP level had a close relation with the development of atherosclerosis in human. Therefore, in the present study, the investigators examined the relationship between circulating A-FABP and vascular inflammation of carotid arteries measured using FDG-PET in healthy male subjects.


Eligibility criteria: Inclusion Criteria:

* Healthy male volunteers for visiting routine medical check in our clinic

Exclusion Criteria:

* History of cardiovascular disease (myocardial infarction, unstable angina,stroke, or cardiovascular revascularization)
* Diabetes
* Hypertension
* Malignancy
* Severe renal or hepatic disease
* Subjects taking medications that might affect inflammation such as NSIAD and statin

Primary outcomes:
measure: Vascular inflammation in carotid arterial wall, represented as the target-to-background ratio (TBR), using FDG-PET
timeFrame: 12 weeks
Secondary outcomes:
measure: Circulating serum A-FABP levels
timeFrame: 12 weeks
measure: Circulating serum leptin levels
timeFrame: 12weeks
measure: Circulating serum adiponectin levels
timeFrame: 12 weeks
measure: Carotid intima-media thickness levels measured using ultrasonography
timeFrame: 12 weeks
Other outcomes:
Locations:
city: Seoul
country: Korea, Republic of
facility: Hye Jin Yoo
Study officials:
affiliation: Korea University
name: Kyung Mook Choi, MD.PhD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT06870006: Psychotropic-Drug-induced QT Prolongation and ECG Monitoring in the Pediatric Population
Official title: Psychotropic-Drug-induced QT Prolongation and ECG Monitoring in the Pediatric Population
Study type: OBSERVATIONAL
Overall status: RECRUITING
Conditions: Eating Disorders
Mood Disorders in Children and Adolescents
Psychotic Disorder
QTc Intervals Changes
Keywords: QTc interval
psychotropic drugs
Lead sponsor: Meyer Children's Hospital IRCCS
Sponsor class: OTHER
First posted: 2025-03-11
Enrollment: 100
Sex: ALL
Maximum age (years): 18
Standard ages: CHILD
ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Children and adolescents referring to psychiatry services in one the participating hospitals starting a new prescription for a psychotropic drug acting on QT interval.

Brief summary: Electrocardiogram (ECG) Q-T prolongation is a cardiac electrophysiological disorder associated with the occurrence of arrhythmias potentially fatal. Several psychotropic drugs are associated with an increased risk of QT prolongation, which is why in clinical practice a baseline ECG is performed before a psychotropic drug is prescribed. However, there are no validated protocols establishing when to repeat this examination or describing clinical events when this examination should be repeated in clinical follow-up.

The study aims to investigate the incidence of QTc prolongation events as a side effect of chronic psychotropic drug administration. For this purpose, ECGs will be recorded and confounding factors of patients at the beginning of psychotropic therapy and after 3, 6 and 12 months will be analyzed.


Eligibility criteria: Inclusion Criteria:

* Admitted to psychiatry ward
* Starting a psychotropic drug acting on QT interval

Exclusion Criteria:

* Age \>18aa
* History of administration of drug acting on QT interval in the 3 months prior

Primary outcomes:
measure: Changes in QT interval
timeFrame: Baseline, 1, 3, 6, 12, 18 months post- enrollment
Secondary outcomes:
measure: Number of Cardiac events
timeFrame: Baseline, 1, 3, 6, 12, 18 months post- enrollment
Other outcomes:
Locations:
city: Florence
country: Italy
facility: AOU Meyer IRCCS
state: FI
Study officials:
References:
Clinical trial NCT03805906: Ultrasound-guided L5 Dorsal Ramus Block
Official title: Ultrasound-guided L5 Dorsal Ramus Block: Description and Validation of a Novel Technique
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Pain, Back
Lead sponsor: Montreal General Hospital
Sponsor class: OTHER
Collaborators: name: University of British Columbia
name: Kelowna General Hospital
First posted: 2019-01-16
Enrollment: 100
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: Patients suffering from chronic low back pain thought to involve the L5 dorsal ramus

Brief summary: This study will examine the accuracy of an ultrasound-guided L5 dorsal ramus block technique.

Detailed description: The lumbar facet joints have been implicated as a causal factor in 15 to 40% of patients suffering from chronic low back pain. Because physical examination and medical imaging have limited value in determining the source of pain, diagnostic blocks play an important role in the management of this common condition. Blocks of the L5 dorsal ramus (DR) are used to diagnosed pain originating from the L5-S1 facet joint, which is one of the most commonly implicated levels in patients with low back pain. Fluoroscopic guidance, which uses x-rays, is currently the standard imaging modality used to perform this block. Recently, ultrasound guidance has seen increasing use because of its greater accessibility and lack of ionizing radiation. Although USG has been shown to provide a high level of accuracy at other levels, the greater anatomical complexity found at the L5-S1 has hindered the development of a satisfactory L5 DR block technique. In this study the investigators will use fluoroscopic control to examine the accuracy of a novel ultrasound-guided approach to this block.

Eligibility criteria: Inclusion Criteria:

-Any consenting patient over 18 years of age with axial low back pain who requires a diagnostic L5 dorsal ramus block.

Exclusion Criteria:

* Inability to consent
* Iodine or lidocaine allergy,
* Pregnancy,
* Coagulopathy (as defined by an INR over 1.4, platelets under 100,000, or a documented bleeding disorder)
* Inability to visualize lumbosacral anatomy during an ultrasound pre- scan

Primary outcomes:
measure: Block accuracy
timeFrame: Immediately post-injection
Secondary outcomes:
measure: Performance time
timeFrame: Perioperative
measure: Number of needle passes
timeFrame: Procedure
Other outcomes:
Locations:
city: Kelowna
country: Canada
facility: Kelowna General Hospital
state: British Columbia
Study officials:
References:
citation: Etheridge JB, De Villiers F, Venter J, Squire P, Farnquist B, Finlayson RJ. Ultrasound-guided L5 dorsal ramus block: validation of a novel technique. Reg Anesth Pain Med. 2020 Mar;45(3):176-179. doi: 10.1136/rapm-2019-100783. Epub 2019 Oct 25.
Clinical trial NCT03235206: Massage Therapy and the Well-Being of Police Officers
Official title: Massage Therapy and the Well-Being of Police Officers
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Occupational Problems
Occupational Injuries
Occupation-related Stress Disorder
Keywords: Police Officers
Lead sponsor: Academy Canada
Sponsor class: OTHER
First posted: 2017-08-01
Enrollment: 6
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: TREATMENT

Brief summary: This study is intend to show the positive impact that massage therapy can have on the lives of police officers. The study will demonstrate how regular treatment can change sleeping quality, stress levels and mental health. It will also investigate the impact that police work can have on the body.


Eligibility criteria: Inclusion Criteria:

* Police Officers preferable working on the street within the St. John's area

Exclusion Criteria:

* Civilians

Primary outcomes:
measure: Muscular Imbalances
timeFrame: After 12 one hour massages
measure: Postural Dysfunctions
timeFrame: After 12 one hour massages
measure: Range of Motion
timeFrame: After 12 one hour massages
Secondary outcomes:
measure: Stress Levels
timeFrame: After 12 one hour massages
measure: Sleep Quality
timeFrame: After 12 one hour massages
measure: Mental Wellness
timeFrame: After 12 one hour massages
Other outcomes:
Locations:
Study officials:
References:
Clinical trial NCT02875106: A Digital Non-interventional Atrial Fibrillation (AF) Screening Study With Commercial Pulse Detection Systems
Official title: BAYathlon - a Digital Non-interventional AF Screening Study to Identify Commercial Pulse Detection Systems (CPDS) Detecting AF and Sinus Rhythm Parallel to ECG Recording Within Routine Clinical Setting
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Atrial Fibrillation
Keywords: Sinus rhythm
Lead sponsor: Bayer
Sponsor class: INDUSTRY
First posted: 2016-08-23
Enrollment: 165
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: Patients for whom the decision to record an ECG was made as per investigator's routine treatment practice

Brief summary: The primary objective in this study is to identify commercial pulse detection systems (CPDS) parallel to electrocardiogram (ECG) recording within routine clinical setting, which are able to detect atrial fibrillation or sinus rhythm of screened patients.


Eligibility criteria: Inclusion Criteria:

* Adult female and male patients for whom the decision to record an ECG was made as per investigator's routine treatment practice
* Patient able and willing to provide signed informed consent

Exclusion Criteria:

* Patients with any comorbidities or abnormalities of heart function or rhythm, which might, in the opinion of the investigator, interfere with the evaluation of study data
* Patients participating in an investigational program with interventions outside of routine clinical practice

Primary outcomes:
measure: The rate of correctly detected atrial fibrillation signals by CPDS in reference to ECG (sensitivity of CPDS).
timeFrame: 120 seconds
Secondary outcomes:
measure: The rate of correctly detected sinus rhythm signals by CPDS in reference to ECG (sensitivity of CPDS).
timeFrame: 120 seconds
measure: The rate of correctly detected AF of the applied algorithm of the ECG-data in reference to the primary diagnosis of the investigator using the ECG-graph (sensitivity of algorithm).
timeFrame: 120 seconds
measure: The rate of correctly detected atrial fibrillation signals by CPDS in reference to ECG (sensitivity of CPDS).
timeFrame: 60 seconds, 180 seconds, 240 seconds, 300 seconds
Other outcomes:
Locations:
city: Multiple Locations
country: Germany
facility: Many Locations
Study officials:
affiliation: Bayer
name: Bayer Study Director
role: STUDY_DIRECTOR
References:
citation: Muller C, Hengstmann U, Fuchs M, Kirchner M, Kleinjung F, Mathis H, Martin S, Blase I, Perings S. Distinguishing atrial fibrillation from sinus rhythm using commercial pulse detection systems: The non-interventional BAYathlon study. Digit Health. 2021 May 22;7:20552076211019620. doi: 10.1177/20552076211019620. eCollection 2021 Jan-Dec.
Clinical trial NCT05923606: Modulation of Brain Oscillations Underlying Working Memory
Official title: State-dependent Modulation of Interactions of Theta and Gamma Rhythms in Working Memory
Study type: INTERVENTIONAL
Overall status: RECRUITING
Phase: NA
Conditions: Working Memory
Keywords: Working memory
Attention
Theta oscillations
Transcranial Alternating Current Stimulation
Lead sponsor: Massachusetts General Hospital
Sponsor class: OTHER
First posted: 2023-06-28
Enrollment: 32
Sex: ALL
Minimum age (years): 18
Maximum age (years): 35
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: CROSSOVER
Primary purpose: BASIC_SCIENCE

Brief summary: This study will use novel transcranial alternating current stimulation (tACS) protocols and electroencephalography (EEG) to modulate and measure brain oscillations that underlie working memory. tACS is a noninvasive method used to modulate the timing and patterns of brain rhythms via weak electric currents passed through electrodes on the scalp.

Detailed description: In this study, healthy adult individuals will perform a spatial working memory task as investigators record scalp EEG before and immediately after undergoing transcranial alternating current stimulation (tACS). Each participant will complete four tACS sessions in randomized order: 1) theta-nested gamma tACS applied during active task periods, 2) theta-nested gamma tACS applied during passive (rest) periods, 3) gamma stimulation applied in phase with ongoing theta oscillations, and 4) placebo tACS. The different stimulation protocols will take place on different days. Therefore, participants will be expected to attend 4 in-person study visits at the Martinos Center for Biomedical Imaging in Charlestown, Massachusetts.

Eligibility criteria: Inclusion Criteria:

* Able to provide informed consent
* Fluent in English.

Exclusion Criteria:

* History of a neurological/psychiatric disorder
* Current use of psychotropic medications
* Current use of substances and drugs that were shown to affect tES (transcranial electrical stimulation) efficacy (dopamine altering drugs, nicotine, NMDA (N-methyl-D-aspartate) antagonists/agonists, sodium/calcium channel blockers, norepinephrine reuptake inhibitors, GABAergic modulators and selective serotonin reuptake inhibitors)
* Contraindications for tACS (e.g., history of seizures, metallic implants in the head or neck, implanted brain stimulators, vagus nerve stimulators, pacemakers, pregnancy)

Primary outcomes:
measure: Working memory accuracy
timeFrame: 2 hours
measure: Working memory accuracy under interference
timeFrame: 2 hours
measure: Theta-gamma cross-frequency coupling
timeFrame: 2 hours
measure: Fronto-parietal theta phase synchronization
timeFrame: 2 hours
Secondary outcomes:
Other outcomes:
Locations:
city: Charlestown
country: United States
facility: Martinos Center for Biomedical Imaging
state: Massachusetts
Study officials:
affiliation: Massachusetts General Hospital
name: Hamdi Eryilmaz, Ph.D.
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT00854906: Keratometric Tear Breakup Time and Fluorescein Tear Breakup Time
Official title: Comparison of Keratometric Tear Break Up Time (KTBUT) to Fluorescein Tear Break Up Time (FTBUT)
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Dry Eye
Keywords: dry eye
keratometer
fluorescein
Lead sponsor: University of Arkansas
Sponsor class: OTHER
First posted: 2009-03-03
Enrollment: 26
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: CASE_ONLY
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Patients from the Jones Eye Clinic, Department of Ophthalmology, University of Arkansas for Medical Sciences

Brief summary: The purpose of the research is to determine if putting fluorescein onto the eye (most common test done for dry eye syndrome) is an accurate way to measure dry eye symptoms. The investigators can avoid placing any foreign substance into the eye by using a manual keratometer. Therefore, the investigators want to compare the measurements of tear breakup time using fluorescein with using a novel method, a manual keratometer and then compare these measurements to a validated dry eye symptoms questionnaire. All qualifying patients who were scheduled in the Jones Eye Institute Clinics for a complete eye exam were offered information about the study and invited to participate. Participants were recruited from February 29, 2009 to April 14, 2009.Participants who did not meet the study protocol's inclusion and exclusion criteria were not included the study or study data analysis. All subjects eyes were measured for KTBUT and FTBUT.

Detailed description: This is an observational study to measure the difference between Keratometric Tear Break Up Time (KTBUT) and Fluorescein Tear Break Up Time (FTBUT). All qualified study participants had their eyes measured for tear break up time measured with a keratometer and with fluorescein dye. In this study, we compare the use of the most common method, fluorescein dye, to measure tear break up time to a novel method, a keratometer, to measure tear break up time. Using the keratometer avoids instilling fluorescein dye into the tear film and not altering the tear film's physiologic environment.

Eligibility criteria: Inclusion Criteria:

* An adult, between ages 18-99
* An adult who is able to understand study instructions

Exclusion Criteria:

* An adult with corneal pathology that prevents accurate assessment of keratometric or fluorescein tear break up time.
* An adult with an allergy to fluorescein, a very common eye dye that detects defects in the cornea.
* The inability to answer questions on your own.

Primary outcomes:
measure: Difference Between Keratometric Tear Break Up Time (KTBUT) and Fluorescein Tear Break Up Time (FTBUT)
timeFrame: 1 day
Secondary outcomes:
measure: Ocular Surface Disease Index (OSDI) Questionnaire
timeFrame: 1 week
Other outcomes:
Locations:
city: Little Rock
country: United States
facility: Jones Eye Institute, University of Arkansas for Medical Sciences
state: Arkansas
Study officials:
References:
Clinical trial NCT04045106: The Acute Effect of Proprioceptive Neuromuscular Facilitation on Cervical Range of Motion, Strength and Proprioception.
Official title: The Acute Effect of Proprioceptive Neuromuscular Facilitation on Cervical Range of Motion, Strength and Proprioception
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Proprioception
Neck
Keywords: Proprioception
Proprioceptive Neuromuscular Facilitation,
Cervical spine
stretching
Lead sponsor: Yeditepe University
Sponsor class: OTHER
Collaborators: name: Bahçeşehir University
First posted: 2019-08-05
Enrollment: 104
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: SCREENING

Brief summary: the aim of the study was to investigate the immediate influence of proprioceptive neuromuscular facilitation on cervical range of motion, strength and proprioception

Detailed description: the study evaluates the influence of two proprioceptive neuromuscular facilitation techniques (PNF patterns and PNF stretching) on cervical proprioception. PNF techniques are regularly used techniques among physiotherapist. also there is a lack of studies that investigated the effect of PNF on cervical proprioception

Eligibility criteria: Inclusion Criteria:

* Neck disability index score of 5 or less
* Able to understand and follow instructions
* Above 18 years old

Exclusion Criteria:

* Cervical trauma
* History of cervical inter-vertebral disc pathology
* Rheumatic diseases
* Whiplash syndrome
* History of surgeries to the neck, face and shoulders
* History of systemic diseases

Primary outcomes:
measure: Cervical Proprioception: Joint position accuracy method using cervical range of motion instrument.
timeFrame: 1 day
Secondary outcomes:
measure: Range Of Motion
timeFrame: 1 day
measure: Muscle strength
timeFrame: 1 day
Other outcomes:
Locations:
city: Ataşehir
country: Turkey
facility: Yeditepe University
state: İstanbul
city: Beşiktaş
country: Turkey
facility: Bahcesehir University
state: Istanbul
Study officials:
affiliation: Yeditepe University
name: SULE DEMIRBASISTANBUL
role: STUDY_DIRECTOR
References:
Clinical trial NCT03365206: Oral Health Among Adolescents.
Official title: Oral Health Knowledge and Practice Among 15-17 Year Old Adolescents.
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Dental Consultation
Lead sponsor: University Hospital, Montpellier
Sponsor class: OTHER
First posted: 2017-12-07
Enrollment: 380
Sex: ALL
Minimum age (years): 15
Maximum age (years): 17
Standard ages: CHILD
Accepts healthy volunteers: yes
Observational model: CASE_ONLY
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: 15 - 17 year old adolescents

Brief summary: The aim of this study is to identify the knowledge and behavior on dental health and hygiene among adolescents. In most cases, the investigators know tooth decay can be prevented and reversed at an early stage by observing good oral hygiene. Few studies have been done among adolescents.

This study could justify the implementation of public health actions in terms of prevention.


Eligibility criteria: Inclusion criteria:

* All adolescents who speek french
* Good general health
* Educated

Exclusion criteria:

* Patients with significant pathologies
* Patients unable to answer questions.
* Non-cooperative patient

Primary outcomes:
measure: knowledge of oral prevention
timeFrame: 1 day
Secondary outcomes:
Other outcomes:
measure: oral habits
timeFrame: 1 day
Locations:
city: Montpellier
country: France
facility: Uhmontpellier
Study officials:
affiliation: University Hospital, Montpellier
name: Camille INQUIMBERT, PhD student
role: PRINCIPAL_INVESTIGATOR
References: