louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT01090219: Polypropylene Meshes in Hernia Repair
Official title: Morphofunctional Evaluations of Heavyweight and Ultralightweight Polypropylene Meshes in Men Inguinal Hernia Repair
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Inguinal Hernias
Keywords: Inguinal Hernia
contraction of two different meshes in the repair of inguinal hernias in men
Lead sponsor: Universidade do Extremo Sul Catarinense - Unidade Academica de Ciecias da Saude
Sponsor class: OTHER
First posted: 2010-03-19
Enrollment: 32
Sex: MALE
Minimum age (years): 20
Maximum age (years): 50
Standard ages: ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The aim of this study was to analyze the shrinkage of two different screens in the repair of inguinal hernias in men . 32 patients with unilateral inguinal hernia were assigned randomly. A Lichtenstein tension-free hernia repair was accomplished by emplacing heavy weight versus ultralight weight polypropylene meshes for repair of incisional hernia, marked next to the lips with six titanium clips (LT200).

Detailed description: eligibility criteria : Elective Surgery, men with unilateral inguinal hernia, 20 - 50 years Exclusion criteria: BMI\> 30, recurrent inguinal hernia, strangulated inguinal hernia, anesthetic risk ASA III and IV, Diabetics, COPD, benign prostatic hypertrophy,cancer disease

outcome: Percentage of contraction of the different meshes by digital radiography in post-surgical days: 1, 30, 60 and 90

Independent variables: age, BMI, smoking, ethnicity, profession

Eligibility criteria: Inclusion Criteria:

* Elective Surgery
* Men with unilateral inguinal hernia
* Age 20 - 50 years

Exclusion Criteria:

* BMI\> 30
* Recurrent inguinal hernia
* Strangulated inguinal hernia
* Anesthetic risk ASA III and IV
* Diabetics
* COPD
* Benign prostatic hypertrophy

Primary outcomes:
measure: contraction of two different meshes in the repair of inguinal hernias in men
timeFrame: digital radiography in post-surgical days: 1, 30, 60 and 90
Secondary outcomes:
Other outcomes:
Locations:
city: Criciúma
country: Brazil
facility: São José Hospital
state: Santa Catarina
city: Criciúma
country: Brazil
facility: Universidade do Extremo Sul Catarinense
state: SC
Study officials:
References:
Clinical trial NCT01618019: N-3 PUFA and Rheumatoid Arthritis in Korea
Official title: Effect of n-3 Polyunsaturated Fatty Acid Supplementation on Patients With Rheumatoid Arthritis
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Rheumatoid Arthritis
Keywords: n-3 PUFA
rheumatoid arthritis
inflammation
eicosanoids
bone turnover markers
Lead sponsor: Hanyang University
Sponsor class: OTHER
First posted: 2012-06-13
Enrollment: 109
Sex: ALL
Minimum age (years): 18
Maximum age (years): 80
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: SUPPORTIVE_CARE

Brief summary: The purpose of this study is to see if supplementation of n-3 polyunsaturated fatty acid (PUFA) can be beneficial for the patients with rheumatoid arthritis.


Eligibility criteria: Inclusion Criteria:

* Patients with rheumatoid arthritis diagnosed based on American College of Rheumatology guideline and receiving NSAID, glucocorticoids, or DMARD were eligible if the dosage had been stable for at least 3 months prior to entering the study.

Exclusion Criteria:

* Patients were excluded if they were pregnant, lactating, under the age of 18 or over age 80, taking supplements containing n-3 PUFA, white blood cell (WBC) ≤ 3.5 × 109/L, hemoglobin (Hb) ≤ 8.5 g/dL, platelet ≤ 100 × 109/L, creatinine ≥ 2.0 mg/dL, and aspartate aminotransferase (AST) or alanine aminotransferase (ALT) ≥ 2.5 times upper limit of normal.

Primary outcomes:
measure: Dose of NSAID
timeFrame: 16 week
Secondary outcomes:
measure: Duration of Morning Stiffness
timeFrame: 16 week
measure: Physician's Global Assessment
timeFrame: 16 week
measure: Patient's Global Assessment
timeFrame: 16 week
measure: Pain Scale
timeFrame: 16 week
measure: Osteocalcin Concentration
timeFrame: 16 week
measure: BSAP Concentration
timeFrame: 16 week
measure: CTX Concentration
timeFrame: 16 week
Other outcomes:
Locations:
city: Seoul
country: Korea, Republic of
facility: Hanyang university hospital
Study officials:
affiliation: Hanyang University
name: Yongsoon Park, PhD
role: PRINCIPAL_INVESTIGATOR
References:
citation: Park Y, Lee A, Shim SC, Lee JH, Choe JY, Ahn H, Choi CB, Sung YK, Bae SC. Effect of n-3 polyunsaturated fatty acid supplementation in patients with rheumatoid arthritis: a 16-week randomized, double-blind, placebo-controlled, parallel-design multicenter study in Korea. J Nutr Biochem. 2013 Jul;24(7):1367-72. doi: 10.1016/j.jnutbio.2012.11.004. Epub 2013 Jan 17.
Clinical trial NCT03742219: Peru Longitudinal Study
Official title: Longitudinal Evaluation of Disease Prevalence in Impoverished Communities of Lima, Peru
Study type: INTERVENTIONAL
Overall status: TERMINATED
Phase: NA
Conditions: Cardiovascular Diseases
Diabetes Mellitus
Hypertension
Dyslipidemias
Overweight and Obesity
Lead sponsor: Ohio University
Sponsor class: OTHER
First posted: 2018-11-15
Enrollment: 861
Sex: ALL
Minimum age (years): 12
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: TREATMENT

Brief summary: The purpose of this study is to evaluate the change in disease prevalence over time in impoverished urban communities in Lima, Peru.

Detailed description: The aim is to track the changes in disease prevalence of people living in impoverished urban communities in Lima over the next 10 years.

Based on data collected in prior years and in an ongoing manner, Ohio University Global Health teams will be introducing interventions focused to positively impact disease states and trends in this population.

The current focus is on chronic lifestyle related diseases and their precursors: cardiovascular disease, hypertension, dyslipidemia, diabetes, and overweight / obesity.

Eligibility criteria: Inclusion Criteria:

* minors age 12-17 presenting to the free community clinic, with a responsible adult who can give consent; minors will give assent.
* consenting adults of any age who present to the clinic.

Exclusion Criteria:

* adults who are unable to give consent.

Primary outcomes:
measure: Weight
timeFrame: yearly for 10 years
measure: Systolic blood pressure
timeFrame: yearly for 10 years
measure: Diastolic Blood Pressure
timeFrame: yearly for 10 years
measure: glycosylated hemoglobin
timeFrame: periodically over 10 years
measure: Total cholesterol
timeFrame: periodically over 10 years
measure: Low-density lipoprotein cholesterol
timeFrame: periodically over 10 years
measure: High density lipoprotein cholesterol
timeFrame: periodically over 10 years
measure: Triglycerides
timeFrame: periodically over 10 years
Secondary outcomes:
measure: Herth Hope Index
timeFrame: yearly for 10 years
measure: Household hunger scale
timeFrame: yearly for 10 years
measure: Patient Health Questionnaire - 4 (PHQ-4)
timeFrame: yearly for 10 years
measure: Exercise vital sign
timeFrame: yearly for 10 years
measure: Perceived Stress Scale
timeFrame: yearly for 10 years
measure: 24 hour dietary recall
timeFrame: yearly for 10 years
Other outcomes:
Locations:
city: Athens
country: United States
facility: Ohio University
state: Ohio
Study officials:
affiliation: Ohio University
name: David S Drozek, DO
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT04355819: Patient Centered Outcomes Study
Official title: Patient Centered Outcomes Among Patients With and Without Ventral Hernia
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Hernia, Ventral
Lead sponsor: The University of Texas Health Science Center, Houston
Sponsor class: OTHER
First posted: 2020-04-21
Enrollment: 500
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: OTHER

Brief summary: Several questions exist when looking at ventral hernias:

1. what is the baseline quality of life and abdominal wall function among patients with or without a ventral hernia?
2. what is the clinical significance of a ventral hernia seen on radiography but not on clinical examination (e.g. occult hernia)?
3. what is the natural history of quality of life of patients with and without a ventral hernia?
4. what is the impact of disclosure of presence or absence of a ventral hernia on quality of life?

Answering these questions can provide valuable information on the impact of surgery with or without subsequent ventral hernia on a patient's abdominal wall function and quality of life.


Eligibility criteria: Inclusion Criteria:

* Adults age 18 years or older
* Patients at LBJ Hospital
* Patients who received a CT of the abdomen

Exclusion Criteria:

* Children (under age 18 years old)
* Any patient in any vulnerable population (e.g pregnant women, prisoners, etc.)

Primary outcomes:
measure: Patient Centered Outcomes (PCO)
timeFrame: Consent to 1 year follow-up
Secondary outcomes:
Other outcomes:
Locations:
city: Houston
country: United States
facility: Lyndon B. Johnson General Hospital
state: Texas
Study officials:
affiliation: The University of Texas Health Science Center, Houston
name: Julie Holihan, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT04890119: Prevalence Study of Amyloidosis in Patients With Surgery of Suspect Bilateral Carpal Tunnel (AMYLYONCARP)
Official title: Prevalence Study of Amyloidosis in Patients With Surgery of Suspect Bilateral Carpal Tunnel (AMYLYONCARP)
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Carpal Tunnel Syndrome Bilateral
Lead sponsor: Centre Hospitalier Saint Joseph Saint Luc de Lyon
Sponsor class: OTHER
First posted: 2021-05-18
Enrollment: 100
Sex: ALL
Minimum age (years): 50
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: DIAGNOSTIC

Brief summary: The purpose of this study is to evaluate the prevalence of amyloidosis in population of patient affected by suspect bilateral carpal tunnel with indication of surgery


Eligibility criteria: Inclusion Criteria:

* bilateral carpal tunnel with indication of surgery and judged suspect:
* age of 50 years old and more
* non-traumatic or undetermined neuropathic etiology or cardiac history (atrial arrhythmia or Heart Failure or cardiac stimulation) or family history of hereditary amyloidosis or monoclonal gammopathy

Exclusion Criteria:

* patient with diagnosis of amyloidosis
* traumatic bilateral carpal tunnel or linked to rheumatoid arthritis

Primary outcomes:
measure: Prevalence of amyloid aggregate
timeFrame: During surgery
Secondary outcomes:
measure: Typing of amyloid aggregate
timeFrame: During surgery
Other outcomes:
measure: Research of organ amyloidosis (context of standard care): exploratory
timeFrame: in the 3 months following surgery
Locations:
city: Lyon
country: France
facility: Centre Hospitalier Saint Joseph Saint Luc
Study officials:
affiliation: Centre Hospitalier Saint Joseph Saint Luc
name: Philippe SCHIELE, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT01027819: Comparison of Outcomes in Mobile and Fixed-bearing Total Knee Arthroplasty
Official title: Comparison of Outcomes in Mobile and Fixed-bearing Total Knee Arthroplasty
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: PHASE4
Conditions: Osteoarthritis of Knee
Keywords: Total knee arthroplasty
Mobile bearing
Fixed bearing
Range of motion
Knee Society Score
Lead sponsor: Seoul National University Hospital
Sponsor class: OTHER
First posted: 2009-12-09
Enrollment: 80
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The purpose of this study is to compare the clinical and radiological outcomes of mobile-bearing with that of fixed-bearing in total knee arthroplasty.

Detailed description: Double blind, randomized prospective study Mobile or fixed bearing of the same company

* Mobile bearing group : group M
* Fixed bearing group : group F

Inclusion criteria

* patients expected primary total knee arthroplasty without severe deformity

Clinical outcomes

* Range of motion
* Complication
* Scorings

  * KSS, KSFS, HSS score, WOMAC score, Oxford score, SF-36

Radiological outcomes

* Alignment angles in knee
* Positions of femoral and tibial components
* Position of patella
* Radiolucency

Eligibility criteria: Inclusion Criteria:

* primary total knee arthroplasty

Exclusion Criteria:

* infection
* severe deformity in knee
* revision

Primary outcomes:
measure: Rotational Angle Between Femur and Tibia
timeFrame: 2 weeks
Secondary outcomes:
measure: Knee Society Score
timeFrame: 6 months
Other outcomes:
Locations:
city: Seoul
country: Korea, Republic of
facility: Seoul National University Hospital
Study officials:
name: Myung Chul Lee, M.D., Ph. D.
role: STUDY_DIRECTOR
References:
Clinical trial NCT02694419: The Effect of Obesity on Endometrium in PCOS
Official title: Effect of Body Weight on Endometrial Ultrasonographic Characteristics in Polycystic Ovary Syndrome Patients
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Body Weight
Polycystic Ovary Syndrome
Keywords: endometrium
Lead sponsor: Assiut University
Sponsor class: OTHER
First posted: 2016-02-29
Enrollment: 100
Sex: FEMALE
Minimum age (years): 18
Maximum age (years): 40
Standard ages: ADULT
Accepts healthy volunteers: no
Observational model: CASE_CONTROL
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: 100 women were recruited from gynecology clinic of Women Health Hospital

Brief summary: The effect of Polycystic Ovary Syndrome (PCOS) with or without obesity has received a few attentions. There is a lack of evidence to whether the BMI affects the endometrial blood flow, which is necessary for implantation.


Eligibility criteria: Inclusion Criteria:

* Women with PCOS are diagnosed according to Rotterdam criteria, (Rotterdam and ASRM-Sponsored, 2004)by the presence of two out of the following three: oligomenorrhea (absence of menses for 35-182 days) or amenorrhea (absence of menses for \>182 days), signs or symptoms of hyperandrogenism (acne, hirsutism), US showing polycystic ovaries.
* Fertile women had regular menstruation, with at least one previous spontaneous pregnancy.

Exclusion Criteria:

* Women known to have hepatic or renal dysfunction, Diabetes mellitus, hypertension, or cardiovascular disease.
* If they have used induction of ovulation drugs for the last three months.
* If they have used hormonal contraception in the last three months.

Primary outcomes:
measure: the mean difference in Doppler indices (VI-FI-VFI)
timeFrame: 24 hours
Secondary outcomes:
Other outcomes:
Locations:
city: Assiut
country: Egypt
facility: Ahmed Abbas
state: Cairo
Study officials:
References:
Clinical trial NCT06677619: Assessment of Changes in Labioincisal Relationship in Deep Bite Correction by Twin Slot Orthodontic Bracket Clinical Trial Study.
Official title: Assessment of Changes in Labioincisal Relationship in Deep Bite Correction by Twin Slot Orthodontic Bracket Clinical Trial Study.
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Percentage of Deep Bite Correction
Lead sponsor: Faculty of Dental Medicine for Girls
Sponsor class: OTHER_GOV
First posted: 2024-11-07
Enrollment: 16
Sex: FEMALE
Minimum age (years): 16
Maximum age (years): 23
Standard ages: CHILD
ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: CROSSOVER
Primary purpose: TREATMENT

Brief summary: Assessment Changes in Labio incisal Relationship in Deep bite Correction by Twin Slot Orthodontic Bracket; clinical trial study.

Detailed description: Group(A): patients will be treated with double slot bracket with wire in incisal slot Group(B):patients will be treated with double slot bracket with wire in cervical slot

Eligibility criteria: Inclusion Criteria:

* • Mild to moderate deep bite.

  * Permanent dentition stage (excluding the third molar)
  * Age ranges from 16-23 years.
  * Free from any medical or systemic condition that could interfere with
  * Orthodontic treatment plane or effect on procedures. Angle class1 or class11 malocclusion with minimal crowding.
  * Female patient to avoide any sexual dimorphism which may affect the comparison.
  * Good oral hygiene.
  * No previous orthodontic treatment.

Exclusion Criteria:

* Uncooperative patient.

  * Frequent missing appointments.
  * Frequent broken appliance.
  * Previous orthodontic treatments.
  * Any systemic or bone diseases.

Primary outcomes:
measure: assessment of smile Line ,smile arch, upper lip line , buccal corridor and amount of intrusion of maxillary incisor
timeFrame: 1year
Secondary outcomes:
measure: percentage of deep bite correction
timeFrame: 1year
Other outcomes:
Locations:
city: Cairo
country: Egypt
facility: Hend Hegazy
Study officials:
affiliation: Professor of Orthodontics
name: Samir A Ibrahem, proffesor
role: PRINCIPAL_INVESTIGATOR
References:
citation: Al-Zoubi EM, Al-Nimri KS. A comparative study between the effect of reverse curve of Spee archwires and anterior bite turbos in the treatment of deep overbite cases. Angle Orthod. 2022 Jan 1;92(1):36-44. doi: 10.2319/020921-117.1.
Clinical trial NCT04555018: Correlation Between Dehydroepiandrosterone Sulfate and Sebum Level in Adult Female Acne Vulgaris
Official title: Correlation Between Dehydroepiandrosterone Sulfate and Sebum Level in Adult Female Acne Vulgaris
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Acne Vulgaris
Female
Keywords: Acne vulgaris
Sebum level
Dehydroepiandrosterone Sulfate
Lead sponsor: Indonesia University
Sponsor class: OTHER
First posted: 2020-09-18
Enrollment: 50
Sex: FEMALE
Minimum age (years): 25
Maximum age (years): 49
Standard ages: ADULT
Observational model: CASE_CROSSOVER
Time perspective: CROSS_SECTIONAL
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Female , age 25-29 years, diagnosed with mild to severe acne vulgaris

Brief summary: The aim of this study is to determine the correlation between Dehydroepiandrosterone sulfate (DHEAS) and sebum level in adult female acne. A cross sectional study was conducted with 50 samples, in June to October 2017.

Detailed description: Epidemiological studies have shown that number of adult female acne vulgaris (AV) increases. Hormone, sebum production, Propionibacterium acne and inflammatory process are factors involved in AV development. The aim of this study is to determine the correlation between Dehydroepiandrosterone sulfate (DHEAS) and sebum level in adult female acne. This research used cross sectional study with 50 samples, aged 25-49 years by consecutive sampling. The degree of acne vulgaris was evaluated using Lehman criteria , and then the sebum level and DHEAS were measured objectively using sebumeter and serum, respectively.

Eligibility criteria: Inclusion Criteria:

* Female, age 25-29 years
* Diagnosed with mild to severe acne vulgaris
* Agree to participate

Exclusion Criteria:

* History of taking antiandrogen drugs
* History of taking oral and topical antibiotics, using topical retinoid and BPO in the last 4 weeks
* History of taking oral isotretinoin in the last 6 months
* Pregnancy or breastfeeding

Primary outcomes:
measure: Sebum level
timeFrame: One day
measure: Dehydroepiandrosterone sulfate
timeFrame: One day
Secondary outcomes:
Other outcomes:
Locations:
city: Jakarta
country: Indonesia
facility: Indonesia dr. Cipto Mangunkusumo Hospital
state: Jakarta Pusat
Study officials:
affiliation: Fakultas Kedokteran Universitas Indonesia
name: Irma B Sitohang, MD,PhD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT01318018: Investigation on the Value of Bilateral Index (BIS) Monitoring for Magnetic Seizure Versus Electroconvulsive Therapy
Official title: Bilateral Bispectral Index Monitoring During and After Electroconvulsive Therapy Compared With Magnetic Seizure Therapy for Treatment-resistant Depression
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Depression
Keywords: depression
bispectral index
electroconvulsive therapy
magnetic seizure therapy
Lead sponsor: University Hospital, Bonn
Sponsor class: OTHER
First posted: 2011-03-18
Enrollment: 20
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: CASE_CONTROL
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: Patients suffering from depression

Brief summary: Electroconvulsive therapy (ECT) has been shown to be an effective treatment for patients suffering from depression, who do not respond to medical treatment. However it is often dismissed by patients, who feel uncomfortably about the application of electric shocks to their heads. In 2000, magnetic seizure therapy (MST) has been introduced which uses magnetism instead of electricity to evoke convulsions. MST seems to be as effective as ECT in terms of its antidepressant potency but may be associated with less severe cognitive side effects.

Control of anaesthesia during seizure therapy is demanding since light anesthesia might be associated with awareness, whereas deep anesthesia impedes the antidepressant effect of the convulsion. Therefore, Bispectral index (BIS) monitoring is frequently used to tailor anaesthesia for ECT, however little is known about BIS following MST.

The investigators hypothesize that in comparing MST with ECT, (a) patients show a faster increase in BIS and that (b)less left-right differences occur in BIS.


Eligibility criteria: Inclusion Criteria:

* depression

Exclusion Criteria:

* age \< 18 years old
* pregnancy

Primary outcomes:
measure: Recovery Time
timeFrame: same day
Secondary outcomes:
Other outcomes:
Locations:
city: Bonn
country: Germany
facility: Dept. of Anaesthesiology and Intensive Care Medicine & Dept. of Psychiatry and Psychotherapy, University of Bonn Hospital
Study officials:
affiliation: Dept of Anaesthesiology and Intensive Care Medicine
name: Martin Soehle, MD, PhD
role: PRINCIPAL_INVESTIGATOR
References:
citation: Soehle M, Kayser S, Ellerkmann RK, Schlaepfer TE. Bilateral bispectral index monitoring during and after electroconvulsive therapy compared with magnetic seizure therapy for treatment-resistant depression. Br J Anaesth. 2014 Apr;112(4):695-702. doi: 10.1093/bja/aet410. Epub 2013 Dec 3.
citation: Jiang J, Zhang C, Li C, Chen Z, Cao X, Wang H, Li W, Wang J. Magnetic seizure therapy for treatment-resistant depression. Cochrane Database Syst Rev. 2021 Jun 16;6(6):CD013528. doi: 10.1002/14651858.CD013528.pub2.