Clinical trial NCT06170034: Post-emergency Management of Patients With Transient Ischemic Attack
Official title: Post-emergency Management of Patients With Transient Ischemic Attack
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Transient Ischemic Attack
Keywords: Emergency
Cerebral RMI
Guidelines compliance
Lead sponsor: Centre Hospitalier Henri Duffaut - Avignon
Sponsor class: OTHER
First posted: 2023-12-14
Enrollment: 49
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: OTHER
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Patients with a diagnosis of TIA in the emergency department

Brief summary: A transient ischemic attack (TIA) is a momentary neurological dysfunction due to a brief cessation of blood flow to a region of the brain, resulting in typical signs of stroke (hemiplegia, aphasia, dysarthria), but whose clinical symptoms typically last less than an hour, with no visible lesion on imaging. This diagnosis remains difficult and is essentially based on the clinical judgment of the physician.

Because a TIA can be a "pre-alarm" for stroke in 20-30% of cases, it needs to be treated appropriately and as early as possible in the emergency department. Stroke rates after untreated TIA are 5% within 48 hours, 10% within one month and 20% within one year. This risk is calculated using the ABCD² score which is based on the patient's risk factors and the clinical manifestations of TIA. Patients with a score ≥ 3 should be hospitalized as soon as possible for a complete medical evaluation. However, this score has not been scientifically validated, and several specialists agree that all TIAs should be evaluated immediately. Preventing stroke is a major public health issue because it is a serious, disabling and sometimes fatal disease. Given the seriousness of the progression from TIA to stroke, the French National Authority for Health has issued a series of management recommendations. However, in practice, these guidelines remain complicated to follow and patients management may vary and be more or less effective.

Therefore, the aim of this study is to highlight the differences in how inpatients and outpatients are managed. Following these observations, solutions will be sought to make the care and management of these patients more efficient and more in line with recommendations.


Eligibility criteria: Inclusion Criteria:

* Patient over 18 years old.
* Consultation in the emergency department.
* Suspected TIA diagnosed by emergency physician.
* Duration of TIA symptoms \<1 hour.

Exclusion Criteria:

* Validation MRI performed prior to suspected TIA.
* Patient hospitalized for a condition other than TIA, including stroke.
* Patient referred to another hospital for further examination.
* Pregnant women.
* Patient unable to understand and answer a questionnaire.
* Patient under legal protection.

Primary outcomes:
measure: Assess time between arrival in the emergency department for suspected TIA patients and MRI.
timeFrame: Baseline
Secondary outcomes:
measure: Time between arrival in the emergency department and MRI by departments.
timeFrame: Baseline
measure: Time between arrival in the emergency department and MRI by ABCD² score.
timeFrame: Baseline
measure: Percentage of patients with complete TIA management by departments.
timeFrame: Baseline
measure: Hospitalization times according to care units
timeFrame: Baseline
measure: Hospitalization times according to complete TIA management
timeFrame: Baseline
measure: Percentage of patients with secondary event, according to complete TIA management
timeFrame: Baseline
measure: Number of outpatients without complete TIA management one month after TIA.
timeFrame: At 1 month follow-up
measure: Patient satisfaction with a short questionnaire
timeFrame: At 1 month follow-up
Other outcomes:
Locations:
city: Avignon
country: France
facility: Centre Hospitalier d'Avignon
Study officials:
affiliation: Centre Hospitalier d'Avignon, Service des urgences
name: Yohan Fouilhe, Medical Intern
role: PRINCIPAL_INVESTIGATOR
References: