louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT04366453: Evaluation of LVEF by a New Automatic Evaluation Tool in a Pocket Ultrasound Scanner
Official title: Evaluation of the Ejection Fraction of the Left Ventricle in the Emergency Room by a New Automatic Evaluation Tool in a Pocket Ultrasound Scanner: A Reproducibility Study
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Echocardiography
Medicine, Emergency
Technology Assessment, Biomedical
Heart Diseases
Lead sponsor: Centre Hospitalier Universitaire de Nīmes
Sponsor class: OTHER
First posted: 2020-04-29
Enrollment: 120
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SEQUENTIAL
Primary purpose: DIAGNOSTIC

Brief summary: Clinical ultrasound has become essential in emergency medicine. The guidelines are to use of echocardiography in specific contexts: dyspnea, hypotension or chest pain. The evaluation of left ventricle ejection fraction (LVEF) is one of the basic objectives of echocardiography. The reference assessment in emergency medicine is visual assessment. It suffers from poor inter-observer reproducibility. Pocket ultrasound scanners seem to meet the constraints of point-of-care ultrasound. A new tool is available on a pocket ultrasound device: the automatic evaluation of LVEF. Its interest could be to have a better inter-observer reproducibility than visual evaluation.


Eligibility criteria: Inclusion criteria:

* Patient over 18 years of age
* Management in the investigator centre
* Admitted for dyspnea or hypotension or chest pain

Exclusion criteria:

* Age \< 18 years
* Patient not benefiting from a social security system
* Patient deprived of liberty
* Patient under the protection of justice, under guardianship or curatorship
* Patient refusing to participate in the study
* Inability to provide the patient with informed information

Primary outcomes:
measure: evaluate the interobserver reproducibility
timeFrame: Day 0
Secondary outcomes:
measure: Assess the interobserver reproducibility of visual LVEF
timeFrame: day 0
measure: Interobserver reproducibility of the visual LVEF measurement;
timeFrame: Day 0
measure: Evaluate the intraobserver reproducibility of the automatic LVEF measurement
timeFrame: Day 0
measure: Ability of the pocket ultrasound scanner to give an ultrasound image useable by the doctor performing the examination.
timeFrame: Day 0
measure: Ability of the pocket ultrasound scanner to give an ultrasound image useable by the doctor performing the examination considering image quality
timeFrame: Day 0
Other outcomes:
Locations:
city: Nîmes Cedex 9
country: France
facility: CHRU de Nîmes - Hôpital Universitaire Carémeau
Study officials:
affiliation: Centre Hospitalier Universitaire de Nîmes
name: Xavier Bobbia, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT04956653: Social Characteristics of Hospitalized Patients With Spinal Degenerative Diseases
Official title: An Analysis of Social Characteristics of Hospitalized Patients With Spinal Degenerative Diseases in the Orthopedic Department of Peking University Third Hospital During 2003-2016
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Spinal Degenerative Diseases
Keywords: Spinal Degenerative Diseases
social characteristics
hospitalized patients
Lead sponsor: Peking University Third Hospital
Sponsor class: OTHER
First posted: 2021-07-09
Enrollment: 32502
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: OTHER
Time perspective: RETROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: A total of 32522 surgical inpatients were selected from Peking University Third Hospital during 2003-2016.

Brief summary: To explore the correlation of the incidence and social characteristics in patients with spinal degenerative diseases (SDD), and to provide certain evidence for prevention, treatment and incidence control of the disease.

Detailed description: Objectives: To explore the correlation of the incidence and social characteristics in patients withspinal degenerative diseases (SDD), and to provide certain evidence for prevention, treatment and incidencecontrol of the disease. Methods: Data between January 1, 2003 to December 31, 2016 were collected from electronic medical documents of the orthopedic department, including patients who suffered from SDD, treated by operation for the first time and aged 18 years old or over. Descriptive statistics and Chi-square test were used to analyze the correlation of social characteristics of patients（eg. age, gender, career, place of birth, nationality and comorbidities）and the degenerative spinal diseases.

Eligibility criteria: Inclusion Criteria:

1. Diagnosed as spinal disc herniation (prolapse), spinal stenosis, Non-traumatic spinal instability, spondylolisthesis, degenerative scoliosis not caused by congenital spinal deformity. 2. Hospitalized patients under operation. 3. Over 18 yrs. 4. Patients in North China.

Exclusion Criteria:

- Patients diagnosed as Hypertrophy of Posterior Longitudinal Ligament or Hypertrophy of Ligamentum Flavum.

Primary outcomes:
measure: Population characteristics of hospitalized patients
timeFrame: 2003-2016
Secondary outcomes:
Other outcomes:
Locations:
city: Beijing
country: China
facility: Peking University Third Hospital
state: Beijing
Study officials:
affiliation: Peking University Third Hospital
name: Yan Li, M.D.
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT06607653: The Efficacy of Olfactory Training Intervention on Olfactory and Other Non-motor Symptoms in PD
Official title: The Efficacy of Olfactory Training Intervention on Olfactory and Other Non-motor Symptoms in PD
Study type: INTERVENTIONAL
Overall status: NOT_YET_RECRUITING
Phase: NA
Conditions: Parkinson Disease
Olfactory Disorder
Olfactory Training
Keywords: Parkinson Disease
Olfactory Disorder
Olfactory training
Lead sponsor: Anhui Medical University
Sponsor class: OTHER
First posted: 2024-09-23
Enrollment: 40
Sex: ALL
Minimum age (years): 40
Maximum age (years): 75
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NON_RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: To explore the efficacy of olfactory training on olfactory and other non-motor symptoms in PD.


Eligibility criteria: Inclusion Criteria:

1. PD was diagnosed according to the criteria of Movement Disorders and Parkinson Disease Group of Chinese Society of Neurology of Chinese Medical Association.
2. Olfactory score was 1 standard deviation lower than the corresponding age norm;
3. no medication plan in the past four weeks or no change in medication plan in the past four weeks, which can be maintained until the end of the experiment; 4.40-75 years old, with normal vision, hearing and language understanding and expression ability;

5.Good cooperation of patients

Exclusion Criteria:

1. Parkinson\&#39;s syndrome and Parkinson\&#39;s plus syndrome caused by cerebrovascular disease, encephalitis, trauma, drugs, etc.;
2. Neuropsychiatric diseases that may affect the sense of smell, such as depression, anxiety, schizophrenia, etc.;
3. History of nasal disease or surgery, such as rhinitis, sinusitis, nasal septum deviation, etc. Upper respiratory tract infection in the past 3 weeks;
4. Long-term smoking and occupations that inhale chemical irritants for a long time.

Primary outcomes:
measure: Olfactory Function Test
timeFrame: baseline;15 weeks
Secondary outcomes:
measure: MoCA
timeFrame: baseline;15 weeks
measure: Pittsburgh sleep quality index
timeFrame: baseline;15 week
measure: HAMA
timeFrame: baseline;15week
measure: HAMD
timeFrame: baseline;15 week
Other outcomes:
Locations:
city: Hefei
country: China
facility: Cognitive Neuropsychology Lab Anhui Medical University
state: Anhui
Study officials:
References:
Clinical trial NCT00548353: A Study of Gastric Delay in Migraine Patients (3207-003)
Official title: A Randomized, Double-Blind, Placebo Controlled, 2-Period, Fixed-Sequence Study to Evaluate the Safety, Tolerability, and Pharmacokinetic Profile of Orally Administered MK3207 in Patients During and Between Their Acute Migraine Attacks
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE1
Conditions: Migraine Disorders
Lead sponsor: Merck Sharp & Dohme LLC
Sponsor class: INDUSTRY
First posted: 2007-10-23
Enrollment: 22
Sex: ALL
Minimum age (years): 18
Maximum age (years): 45
Standard ages: ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: A study to assess safety and PK of an investigational drug in migraine patients during and between migraine attacks.


Eligibility criteria: Inclusion Criteria:

* Non-smoking male or female between 18 to 45 years of age
* Patient typically has between 2 and 10 migraine attacks per month, rated as moderate or severe

Exclusion Criteria:

* Patient has any other medical conditions other than migraine

Primary outcomes:
measure: Safety in migraine patients
timeFrame: 12 Weeks
Secondary outcomes:
measure: PK in migraine patients
timeFrame: 12 Weeks
Other outcomes:
Locations:
Study officials:
affiliation: Merck Sharp & Dohme LLC
name: Medical Monitor
role: STUDY_DIRECTOR
References:
Clinical trial NCT06712953: The Effect of Repeated Standardized Patient Use on Students' Anxiety and Learning Levels in Teaching Extremity Examination Skills
Official title: The Effect of Repeated Standardized Patient Use on Students' Anxiety and Learning Levels in Teaching Extremity Examination Skills
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Nursing Students
Keywords: Anxiety
self-confidence
active learning
passive learning
psychomotor skills
standardized patient
peer
extremity
Lead sponsor: Suleyman Demirel University
Sponsor class: OTHER
First posted: 2024-12-03
Enrollment: 67
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: OTHER

Brief summary: Aims: This study aimed to examine the effects of peer assessment and repeated standardized patient use on students' self-confidence and anxiety and their psychomotor skill performance in teaching extremity examination skills.

Design: This randomized controlled experimental study was carried out following the CONSORT checklist.

Methods: The study sample consisted of second-grade nursing students enrolled in the " Health Diagnosis" course in the fall semester of the 2023-2024 academic year (n:67). The students in the peer assessment group performed the upper and lower extremity examinations once whereas those in the standardized patient group performed these examinations three times. Research data were analyzed in IBM SPSS 25.0 (Statistical Package for Social Sciences) software. The Shapiro-Wilk test was used to check whether the data were normally distributed. Parametric and nonparametric tests and descriptive statistical methods were used for data analysis. The significance levels were taken as p\<0.001 and p\<0.05. The scales used were analyzed with the Cronbach alpha reliability coefficient; the scenarios and forms created by the researchers were evaluated with the Lawshe Technique.


Eligibility criteria: Inclusion Criteria:

* Second-grade nursing students
* Enrolled in the " Health Diagnosis" course at the Faculty of Health Sciences, Department of Nursing of a university in the fall semester of the 2023-2024 academic year

Exclusion Criteria:

- Students who actively continue their nursing profession as well as their education life

Primary outcomes:
measure: Extremity examinations
timeFrame: First week
Secondary outcomes:
Other outcomes:
measure: First measurement (Self-conficent and Anxiety)
timeFrame: First week
measure: Second measurement (Self-conficent and Anxiety)
timeFrame: Third week
measure: Third measurement (Self-conficent and Anxiety)
timeFrame: fifth week
Locations:
city: Isparta
country: Turkey
facility: Suleyman Demirel University
state: Center
Study officials:
References:
citation: Aydin AG, Ince S. The effect of Jigsaw technique on nursing students' psychomotor skill levels and academic achievement: A quasi-experimental study. Nurse Educ Pract. 2023 Nov;73:103821. doi: 10.1016/j.nepr.2023.103821. Epub 2023 Oct 30.
Clinical trial NCT00991653: Weight Fluctuation After Breast Cancer Treatment
Official title: Weight Fluctuation After Breast Cancer Treatment
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Breast Cancer
Weight Gain
Keywords: Weight
Breast
Cancer
Lead sponsor: The Royal Bournemouth Hospital
Sponsor class: OTHER
First posted: 2009-10-08
Enrollment: 250
Sex: FEMALE
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: CROSS_SECTIONAL
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Females over 18 years diagnosed with breast cancer between 1/1/2003 and 31/12/2007.

Brief summary: This study aims to identify and quantify the factors associated with excess weight gain following treatment for breast cancer. It is believed that breast cancer patients gain more than 4% of their weight at diagnosis which is likely accompanied by an increase in body fat and waist circumference. It is further thought that this excess weight and increase in body fat and waist circumference are associated to tumour characteristics, chemotherapy, menopause status at diagnosis and the presence of genes related to obesity. It is also thought that women treated with chemotherapy have higher levels of glucose and insulin.


Eligibility criteria: Inclusion Criteria:

* Females 18 years of age or older.
* Diagnosed with breast cancer between 1/1/2003 and 31/12/2007.
* Able to understand and willing to sign informed consent.

Exclusion Criteria:

* Known diagnosis of previous breast/other cancer (other than completely resected non-melanoma skin cancer or successfully treated in situ cancer of the cervix.
* Known diagnosis of inflammatory bowel disease or malabsorption syndrome.
* Known diagnosis of endocrine problems associated with the development of obesity (cushings syndrome, hypo/hyperthyroid, thyroiditis)
* Treatment for psychiatric disorders.

Primary outcomes:
measure: To provide evidence of the relationship between weight gain following diagnosis of breast cancer and tumour characteristics, chemotherapy, menopause status at diagnosis and the presence of genes related to obesity.
timeFrame: 12-18 months.
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
affiliation: Royal Bournemouth and Christchurch Hospitals NHS Foundation Trust
name: Tamas Hickish
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT02127853: Effect of Gabapentin on Pain of the Second Cataract Surgery
Official title: The Effect of Pretreated Gabapentin on Hyeralgesia Occurring in the Second Operation in Staged Bilateral Cataract Surgery
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: PHASE4
Conditions: Hyperalgesia
Keywords: serial cataract surgery
hyperalgesia
gabapentin
central sensitization
Lead sponsor: Seoul National University Hospital
Sponsor class: OTHER
First posted: 2014-05-01
Enrollment: 70
Sex: ALL
Minimum age (years): 20
Maximum age (years): 80
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: Gabapentin pretreatment may reduce hyperalgesia occurring at the second surgery in serial, bilateral cataract surgery.

Detailed description: Hyperalgesia occurring at the second operation in bilateral eye surgery is well known, and mechanism of central sensitization might be involved. Gabapentin is known to lower the effect of central sensitization, and its effect on acute postoperative pain has been reported. Therefore, pretreatment of gabapentin after first operation may reduce the pain at second operation.

Eligibility criteria: Inclusion Criteria:

* Patient of ASA(American Cociety of Anesthesiology) class I, II, III between age 20 to 80, scheduled for serial bilateral cataract surgery(1 weel interval)

Exclusion Criteria:

* refuse to participate
* BMI\<16 or BMI \>30
* severe cardiovascular, pulmonary, renal disease
* alcohol or drug abuse
* currently taking CNS(central nervous system) inhibitory drugs
* taking antiacids
* depressive disorder pregnancy

Primary outcomes:
measure: proportion of subjects who answer that "pain was greater" in the second eye surgery
timeFrame: Intra operative (pain while fluid injection to anterior chamber)
Secondary outcomes:
measure: perioperative pain
timeFrame: end of surgery, post-op 1hr at PACU, at out-patient ward, post-op 1 day
Other outcomes:
measure: satisfaction
timeFrame: intra operative
measure: anxiety
timeFrame: baseline (at OR room arrival, just before sterile draping)
Locations:
city: Seoul
country: Korea, Republic of
facility: Seoul National University Hospital
Study officials:
References:
Clinical trial NCT06173453: Factors Associated With Survival in Patients Having Pneumocystis Jirovecii
Official title: Factors Associated With Survival in Patients With a Positive Sample for Pneumocystis Jirovecii at the Strasbourg University Hospital: a Retrospective Study From 2016 to 2018
Study type: OBSERVATIONAL
Overall status: RECRUITING
Conditions: Pneumocystis Jirovecii Infection
Keywords: P jirovecii Infection
Pneumocystis Infections
Pneumocystis jirovecii Infection
Pneumocystis jirovecii
Pneumonia
Pneumocystis
Lead sponsor: University Hospital, Strasbourg, France
Sponsor class: OTHER
First posted: 2023-12-15
Enrollment: 300
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: CASE_ONLY
Time perspective: RETROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Adult patients with a positive respiratory sample for P. jirovecii

Brief summary: Pneumocystis jirovecii is a fungus that can colonize the airways of some patients and be responsible for a disease called pneumocystosis in other patients and mainly in immunocompromised patients.

Pneumocystosis was mainly linked to HIV in the 1990s, but with the advent of new immunosuppressive molecules used in cancers or autoimmune diseases and with the increase in the number of transplants, the epidemiology has changed in recent years.

Studies on P. jirovecii-related mortality are only based on patients with pneumocystosis. As a result, patients who are simply colonized or patients who are sick but not treated are not taken into account in these studies. The investigators therefore wish to study the overall mortality at six weeks and at three months in all patients with a positive sample for P. jirovecii


Eligibility criteria: Inclusion criteria:

* Adult patients with a positive respiratory sample for P. jirovecii cared for in Strasbourg University Hospitals between 01/01/2016 and 31/12/2018. Positive samples are defined as a direct examination finding cysts or trophozoites after staining with May-Grunewald-Giemsa and/or Gomori-Grocott, a positive P. jirovecii PCR on sputum, tracheal aspirates or bronchial fluid -alveolar
* Subject not objecting to the reuse of their data for scientific research purposes.

Exclusion criteria:

- Subject having expressed its opposition to the reuse of its data for scientific research purposes.

Primary outcomes:
measure: Survival at six weeks and three months after infection
timeFrame: six weeks after infection
Secondary outcomes:
Other outcomes:
Locations:
city: Strasbourg
country: France
facility: Service des Maladies Infectieuses et Tropicales - CHU de Strasbourg - France
Study officials:
References:
Clinical trial NCT04560153: Interest of Karate Kata Practice on the Self-esteem of Patients Living With HIV
Official title: Interest of Karate Kata Practice on the Self-esteem of Patients Living With HIV
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Patients Living With HIV
Keywords: HIV
KARATE KATA
SELF ESTEEM
Lead sponsor: Centre Hospitalier le Mans
Sponsor class: OTHER
First posted: 2020-09-23
Enrollment: 35
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: SUPPORTIVE_CARE

Brief summary: Since ancient times, physical and sports activity has been recognized as bringing many health benefits. Descriptive and interventional studies on physical activity are developing, demonstrating physical and psychological benefits for patients with various diseases.

Physical activity is effective in improving self-esteem in the general population. Good self-esteem allows for better autonomy to manage a chronic illness.

The benefit of physical activity in patients living with HIV has been the subject of several studies, notably outside France, and seems to improve the quality of life.

We hypothesize that sport, especially karate kata, could improve self-esteem in patients living with HIV, and represent another non-drug aid, in patients living with HIV.


Eligibility criteria: Inclusion Criteria:

* patient living with HIV
* Patient seen in the infectious diseases department of Le Mans hospital, during a consultation or day hospitalization for HIV follow-up
* Aged 18 years and older
* Patients able to understand and to give informed consent to participate in the study
* valid social security coverage
* written and signed informed consent by the patient and investigator

Exclusion Criteria:

* refusal to participate to the study
* pregnant or brest-feeding women
* person subject to a legal protection measure
* patient with psychiatric disease
* patient under legal protection
* medical contraindication to play karate kata

Primary outcomes:
measure: Effect of karate kata training on self-esteem among patients living with HIV followed at the Le Mans hospital center
timeFrame: 4 months
Secondary outcomes:
Other outcomes:
Locations:
city: Le Mans
country: France
facility: Centre Hospitalier Du Mans
Study officials:
References: