Clinical trial NCT06163287: Hydrogen-Rich Water and Exercise-Related Biomarkers in Men and Women Over 50 Years
Official title: The Effects of Drinking Hydrogen-rich Water for 6 Weeks on Exercise-related Biomarkers in Men and Women Over 50 Years Following Resistance Training Program: a Randomized Controlled Pilot Trial
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Aging
Lead sponsor: University of Novi Sad, Faculty of Sport and Physical Education
Sponsor class: OTHER
First posted: 2023-12-08
Enrollment: 28
Sex: ALL
Minimum age (years): 50
Maximum age (years): 65
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: PREVENTION

Brief summary: The study investigates the impact of consuming hydrogen-rich water over a six-week period on exercise-related biomarkers among individuals aged over 50, both men and women, who undergo a resistance training program. This research aims to discern the potential benefits of hydrogen-infused water consumption concerning exercise-related markers in an aging demographic post-resistance training.


Eligibility criteria: Inclusion Criteria:

* Age 50 - 65 years (at least 50% would be over 60 years)
* Body mass index 18.5 - 29.9 kg/m2
* Free of major chronic diseases or acute disorders
* Resistance exercise naïve (no resistance traiing during 6 months before study commences)

Exclusion Criteria:

* History of dietary supplement use during the 4 weeks before study commences
* Unwillingness to return for follow-up analysis

Primary outcomes:
measure: 36-Item Short Form Health Survey
timeFrame: Change from baseline 36-Item Short Form Health Survey total score at 6 weeks
Secondary outcomes:
measure: Grip strength
timeFrame: Change from baseline grip strength at 6 weeks
measure: Myoglobin
timeFrame: Change from baseline serum myoglobine at 6 weeks
measure: Pittsburgh Sleep Quality Index
timeFrame: Change from baseline Pittsburgh Sleep Quality Index score at 6 weeks
measure: Dehydroepiandrosterone
timeFrame: Change from baseline serum dehydroepiandrosterone at 6 weeks
Other outcomes:
Locations:
city: Novi Sad
country: Serbia
facility: FSPE Applied Bioenergetics Lab
state: Vojvodina
Study officials:
affiliation: University of Novi Sad
name: Sergej Ostojic, MD, PhD
role: PRINCIPAL_INVESTIGATOR
References:
citation: Zanini D, Todorovic N, Korovljev D, Stajer V, Ostojic J, Purac J, Kojic D, Vukasinovic E, Djordjievski S, Sopic M, Guzonjic A, Ninic A, Erceg S, Ostojic SM. The effects of 6-month hydrogen-rich water intake on molecular and phenotypic biomarkers of aging in older adults aged 70 years and over: A randomized controlled pilot trial. Exp Gerontol. 2021 Nov;155:111574. doi: 10.1016/j.exger.2021.111574. Epub 2021 Oct 1.
citation: Korovljev D, Trivic T, Drid P, Ostojic SM. Molecular hydrogen affects body composition, metabolic profiles, and mitochondrial function in middle-aged overweight women. Ir J Med Sci. 2018 Feb;187(1):85-89. doi: 10.1007/s11845-017-1638-4. Epub 2017 May 30.
citation: Korovljev D, Stajer V, Javorac D, Ostojic SM. Hydrogen inhalation positively affects cardiometabolic risk factors in men and women aged 65 years or older: a preliminary report. Eur Geriatr Med. 2018 Oct;9(5):729-730. doi: 10.1007/s41999-018-0087-6. Epub 2018 Jul 31. No abstract available.