Clinical trial NCT03076099: Dexmedetomidine on Post-operative Blood Pressure in Bain Arteriovenous Malformation Embolization
Official title: Effects of Dexmedetomidine on Post-operative Blood Pressure in Patients Undergoing Brain Arteriovenous Malformation Embolization
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Anesthesia
Keywords: Dexmedetomidine
brain arteriovenous malformation
embolization
post-operative hypertension
Lead sponsor: First Affiliated Hospital, Sun Yat-Sen University
Sponsor class: OTHER
First posted: 2017-03-09
Enrollment: 30
Sex: ALL
Minimum age (years): 18
Maximum age (years): 65
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Intervention model description: two parallel groups
Primary purpose: TREATMENT

Brief summary: Aim of this trial is to study the effect of Dexmedetomidine on post-operative blood pressure in patients undergoing brain arteriovenous malformation embolization. The patients were randomized allocated to either Dexmedetomidine group or Control group. Patients in Dexmedetomidine group will receive intravenous Dexmedetomidine while the control group will receive normal saline. Post-operative anti-hypertensive drug, Visual analogue score,post-operative analgesics consumption, Quality of Recovery score, Ramsay score, and adverse events were recorded.

Detailed description: Aim of this trial is to study the effect of Dexmedetomidine on post-operative blood pressure in patients undergoing brain arteriovenous malformation embolization. The patients were randomized allocated to either Dexmedetomidine group or Control group according to a random number. Patients in Dexmedetomidine group will receive intravenous Dexmedetomidine while the control group will receive normal saline. Post-operative anti-hypertensive drug, Visual analogue score,post-operative analgesics consumption, Quality of Recovery score-15 items, Ramsay score, and adverse events were recorded.

Eligibility criteria: Inclusion Criteria:

* patients undergoing brain arteriovenous malformation embolization in the fist affiliated hospital, Sun Yat-sen University, aged 18-65 years, available to chat with,and the tracheal tube was extubated after surgery immediately.

Exclusion Criteria:

* abuse anesthetic analgesics and sedative drugs, or allergic to Dexmedetomidine or other anesthetics, hypotension or bradycardia before surgery, severe pulmonary disease with saturation of pulse oximetry less than 90% before surgery, or patients refused to attend in this study.

Primary outcomes:
measure: urapidil consumption
timeFrame: the end of the 6th hour after tracheal extubation
Secondary outcomes:
measure: urapidil consumption on POD1
timeFrame: the total consumption of urapidil on post-operative day 1.
measure: urapidil consumption on POD2
timeFrame: the total consumption of urapidil on post-operative day 2.
measure: Visual Analogue score
timeFrame: the end of the 6th hour after tracheal extubation
measure: Visual Analogue score at 24th hour
timeFrame: the end of the 24th hour after tracheal extubation
measure: Visual Analogue score at 48th hour
timeFrame: the end of the 48th hour after tracheal extubation
measure: Quality of Recovery Score
timeFrame: the end of the 6th hour after tracheal extubation
measure: Quality of Recovery Score at 24th hour
timeFrame: the end of the 24th hour after tracheal extubation
measure: Quality of Recovery Score at 48th hour
timeFrame: the end of the 48th hour after tracheal extubation
measure: Analgesics consumption
timeFrame: the end of the 6th hour after tracheal extubation
measure: Analgesics consumption on POD1
timeFrame: the total consumption of urapidil on post-operative day 1.
measure: Analgesics consumption on POD2
timeFrame: the total consumption of urapidil on post-operative day 2.
measure: Bradycardia
timeFrame: the end of the 6th hour after tracheal extubation
measure: Bradycardia at 24th hour
timeFrame: the end of the 24th hour after tracheal extubation
measure: Bradycardia at 48th hour
timeFrame: the end of the 48th hour after tracheal extubation
measure: PONV
timeFrame: the end of the 6th hour after tracheal extubation
measure: PONV at 24th hour
timeFrame: the end of the 24th hour after tracheal extubation
measure: PONV at 48th hour
timeFrame: the end of the 48th hour after tracheal extubation
Other outcomes:
Locations:
city: Guangzhou
country: China
facility: the First Affiliated Hospital of Sun Yetsen University
state: Guangdong
Study officials:
References: