Clinical trial NCT05483036: Perception in Parkinson's Disease
Official title: Perception in Parkinson's Disease
Study type: OBSERVATIONAL
Overall status: RECRUITING
Conditions: Parkinson's Disease
Perception
Visual Hallucination
Lead sponsor: Boston University Charles River Campus
Sponsor class: OTHER
First posted: 2022-08-01
Enrollment: 60
Sex: ALL
Minimum age (years): 40
Maximum age (years): 110
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: CASE_ONLY
Time perspective: CROSS_SECTIONAL
Sampling method: NON_PROBABILITY_SAMPLE
Study population: PwPD volunteering for an online study

Brief summary: The investigators plan to examine the relation of perceptual variables-basic vision, unusual perceptual experiences(including but not limited to visual hallucinations)-to relevant functional variables such as cognition, mood, and alertness/sleepiness in an online sample of persons with Parkinson's disease (PwPD). It is hypothesized that unusual perceptual experiences will relate significantly to the selected variables. Participants do not need to experience visual hallucinations to be able to participate in this study. This is an observational study only, and not an interventional study.

Detailed description: For this study, the investigators propose to conduct an online study of PwPD (proposing a total of 60 participants) to examine the relations among variables that may relate to perception in PD. Those PwPD who express interest will be sent a link to an online survey (Qualtrics). The investigators will collect demographic and health information, followed by questionnaires assessing unusual perceptual experiences, mood, motivation, sleep, fatigue and quality of life. The survey should take roughly 45 minutes to an hour to complete.

Compensation: A $20 Amazon gift card will be offered to those who complete the survey all the way through with good effort.

Eligibility criteria: Inclusion Criteria:

* Participants must be at least 40 years old
* Have a self-reported diagnosis of idiopathic PD
* Be proficient English speakers
* Have functional vision
* Have internet access, and access to a desktop computer or laptop

Exclusion Criteria:

* Self-reported poor vision (non-functional range)
* Lack of access to internet and either a desktop computer or laptop

Primary outcomes:
measure: Noise Pareidolia Test
timeFrame: Baseline
measure: Mooney Faces
timeFrame: Baseline
measure: BU Hallucinations and Unusual Perceptual Experiences questionnaire (BU-HUPE)
timeFrame: Baseline
measure: Prodromal Questionnaire, Brief Version (PQ-B)
timeFrame: Baseline
measure: Parkinson's Disease - Psychotic Symptoms Scale (PD-PSS)
timeFrame: Baseline
measure: Penn Online Evaluation of Migraine (POEM)
timeFrame: Baseline
measure: Epworth Sleepiness Scale (ESS)
timeFrame: Baseline
measure: Parkinson's Disease Sleep Scale-2
timeFrame: Baseline
measure: Parkinson's Anxiety Scale (PAS)
timeFrame: Baseline
measure: Center for Epidemiological Studies Depression Scale (CES-D)
timeFrame: Baseline
measure: Parkinson's Disease Questionnaire - 39 (PDQ-39)
timeFrame: Baseline
measure: NIH NeuroQoL measures
timeFrame: Baseline
measure: The Movement Disorders Society Unified Parkinson Disease Rating Scale (MDS-UPDRS)
timeFrame: Baseline
measure: Non-Motor Symptoms Questionnaire (NMSQ)
timeFrame: Baseline
Secondary outcomes:
Other outcomes:
Locations:
city: Boston
country: United States
facility: Vision and Cognition Laboratory, Boston University
state: Massachusetts
Study officials:
affiliation: Boston University
name: Alice Cronin-Golomb, PhD
role: PRINCIPAL_INVESTIGATOR
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