Clinical trial NCT02909413: Comparison of Desflurane With Sevoflurane for School-age Children in Postoperative Cognitive Function
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Postoperative Cognitive Dysfunction
Keywords: desflurane
sevoflurane
Lead sponsor: Shengjing Hospital
Sponsor class: OTHER
First posted: 2016-09-21
Enrollment: 600
Sex: ALL
Minimum age (years): 6
Maximum age (years): 14
Standard ages: CHILD
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: HEALTH_SERVICES_RESEARCH

Brief summary: This study compares desflurane with sevoflurane for school-age children in postoperative cognitive function.

Detailed description: The postoperative cognitive dysfunction (POCD) of school-age children (6-14 age) after operation draw more attention from both society and family. It is well known that, compare with sevoflurane, desflurane could improve cognitive function in elderly patients. But whether Desflurane could improve postoperative cognitive function compare with Sevoflurane for the school-age children, there is no consistent conclusion.

Eligibility criteria: Inclusion Criteria:

* 6-14 age, elective no-cardiac and non-neurological surgery , ASA physical statusⅠorⅡ, no preoperative cognitive function impairment, cooperate to complete the entire test.

Exclusion Criteria:

* Allergic to halogens inhaled anesthetics, malignant hyperthermia susceptible patients, intracranial hypertension, emotional disorder, hyperactivity, history of operation, mental retardation, audio-visual obstacles, history of congenital heart disease, Important organ dysfunction, history of drug abuse
* History of epilepsy
* Preoperative respiratory infection significantly.

Primary outcomes:
measure: The incidence of postoperative cognitive dysfunction
timeFrame: Within 7 days after operation
Secondary outcomes:
measure: age
timeFrame: 1 day before operation
measure: male
timeFrame: 1 day before operation
measure: height
timeFrame: 1 day before operation
measure: weight
timeFrame: preoperation
measure: previous operation history
timeFrame: preoperation
measure: the duration of anesthesia
timeFrame: From the time began to give the anesthetic to the time of pull out the endotracheal intubation
measure: the duration of operation
timeFrame: Surgery end time minus the start time
measure: total blood loss
timeFrame: The total blood loss of the whole surgery time.
measure: total volume of infusion
timeFrame: The total volume of infusion of the whole surgery time.
measure: whether there is respiratory depression in postanesthesia care unit
timeFrame: The period which the patient stay at post anesthesia care unit,from the time enter to postanesthesia care unit to the time leave postanesthesia care unit,the estimated period is up to 30 minutes.
measure: the length of hospital stay
timeFrame: the time from admission to hospital to discharge from hospital,the estimated period is up to 5 days.
measure: S100β
timeFrame: 1 day after surgery
measure: NSE
timeFrame: 1 day after surgery
Other outcomes:
Locations:
Study officials:
References:
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