Clinical trial NCT01096537: Early Incidence of Occupational Asthma Among Bakers, Pastry-makers and Hairdressers
Official title: Evolution of the Incidence of Occupational Asthma at the Beginning of the Activity of Young Bakers, Pastry-makers and Hairdressers, and Exploration of Its Risk Factors
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Occupational Asthma
Keywords: incidence
young workers
occupations at risk
public health
epidemiology
polymorphisms
gentic
Lead sponsor: Central Hospital, Nancy, France
Sponsor class: OTHER
Collaborators: name: Institut National de la Santé Et de la Recherche Médicale, France
name: University of Nancy
First posted: 2010-03-31
Enrollment: 866
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: COHORT
Time perspective: RETROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: All bakers, pastry-makers and hairdressers who graduated between 2001 and 2006 from nine vocational schools in Lorraine, North-Eastern France, and all subjects who graduated in 2001 in the sale or the food sectors (butcher, pork butcher, caterer, cook job,...) from the same vocational schools.

Brief summary: Background: Occupational exposures are thought to be responsible for 10-15% of new-onset asthma cases in adults, with disparities across sectors. Because most of the data are derived from registries and cross-sectional studies, little is known about incidence of occupational asthma (OA) during the first years after inception of exposure. This study focuses on this early asthma onset period among young workers in the bakery, pastry making and hairdressing sectors in order to assess early incidence of OA in these "at risk" occupations according to exposure duration, and to identify risk factors of OA.

Methods: This study is a longitudinal retrospective study with a nested case-control to identify risk factors of OA. The assessment of incidence evolution is made by exploring a series of promotions (or retrospective cohorts) with increasing duration since at work. The study population is composed of subjects who graduated between 2001 and 2006 in sectors where they experience exposure to organic or inorganic allergenic or irritant compounds (with an objective of 150 subjects by year) and 250 young workers with no specific occupational exposure.

This study is a descriptive, monocentric, longitudinal and retrospective study with cross-sectional measurements.


Eligibility criteria: Inclusion Criteria:

* for the exposed group: to be graduated between 2001 and 2006 from nine vocational schools in Lorraine, North-Eastern France
* for the "non-exposed" group: to be graduated in 2001 in the sale or the food sectors (butcher, pork butcher, caterer, cook job,...) from the same vocational schools

Exclusion Criteria:

* asthma diagnosed before apprenticeship
* for the "non-exposed" group: to have worked previously or later in a sector at risk with OA

Primary outcomes:
measure: The early incidence of OA among young workers according to their sector of activity and exposure duration.
timeFrame: 3-6 months after tle last inclusion
Secondary outcomes:
measure: The identification of risk factors of OA.
timeFrame: 3-6 months after the last inclusion
Other outcomes:
Locations:
city: Nancy
country: France
facility: CHU Nancy
Study officials:
affiliation: CHU Nancy, INSERM, Nancy University
name: Christophe PARIS, MD / PhD
role: PRINCIPAL_INVESTIGATOR
affiliation: INSERM, Nancy university, EHESP School of Public Health
name: Denis ZMIROU-NAVIER, MD / PhD
role: PRINCIPAL_INVESTIGATOR
References:
citation: Remen T, Coevoet V, Acouetey DS, Gueant JL, Gueant-Rodriguez RM, Paris C, Zmirou-Navier D. Early incidence of occupational asthma among young bakers, pastry-makers and hairdressers: design of a retrospective cohort study. BMC Public Health. 2010 Apr 26;10:206. doi: 10.1186/1471-2458-10-206.