Clinical trial NCT03635554: Translation and Clinical Implementation of a Test of Language and Short-term Memory in Aphasia
Official title: Translation and Clinical Implementation of a Test for Language and Short-term Memory in Aphasia
Study type: OBSERVATIONAL
Overall status: ENROLLING_BY_INVITATION
Conditions: Aphasia
Keywords: Aphasia
Lead sponsor: Temple University
Sponsor class: OTHER
Collaborators: name: University of Washington
First posted: 2018-08-17
Enrollment: 150
Sex: ALL
Minimum age (years): 21
Maximum age (years): 80
Standard ages: ADULT
OLDER_ADULT
Observational model: CASE_CONTROL
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Participants with aphasia will have single or multiple left hemisphere lesions, but no right hemisphere lesions. They can be between the ages of 21 and 80. Their aphasia can range in severity from mild to severe and can be of any type except global aphasia. Their language output can be fluent or nonfluent and their comprehension can be mild moderately impaired.

Brief summary: This project aims to develop a clinically feasible version of a laboratory-developed assessment battery for language and verbal short-term memory difficulties in aphasia.

Detailed description: Over five years, we will develop a clinically feasible test that can be used to assess in-depth the language and verbal short-term memory abilities of individuals with aphasia (Called the TALSA - Temple Assessment of Language and Short-term memory in Aphasia. Based on a test that we have developed and tested over the past decade, we will create a shorter version that can be used by clinicians in a rehabilitation setting. The data to support this development will come from two sources: (1) clinicians in rehabilitation facilities who will use the new clinical test and provide feedback on the test (administration, value etc) and (2) people with aphasia who will be administered the longer version to help us identify the best test items in the laboratory version of the TALSA to be carried over to the shorter clinical version.

We are recruiting individuals with aphasia as well as people without aphasia (to serve as controls) to help with development of this assessment battery. The battery consists of between 15 and 20 subtests that assess many aspects of language and verbal short-term memory.

Eligibility criteria: Inclusion Criteria:

* . single or multiple left hemisphere lesions
* at least one year post-stroke.
* high-school educated
* negative histories for mental illness and alcohol/substance abuse.
* passed an audiometric pure-tone, air conduction screening at 25 dB HL at 1K, 2K and 4K Hz for at least one ear.

Exclusion Criteria:

English as a second language Right hemisphere stroke Less than 6 months post-onset of stroke.

Primary outcomes:
measure: Proportions correct on subtests of the Test of Language and Short-term Memory in Aphasia (TALSA)
timeFrame: two to three years December 1, 2017 through December 15, 2017 through November 30, 2022.
Secondary outcomes:
Other outcomes:
Locations:
city: Philadelphia
country: United States
facility: Temple University
state: Pennsylvania
Study officials:
affiliation: Temple University
name: Nadine Martin, Ph.D.
role: PRINCIPAL_INVESTIGATOR
References: