Clinical trial NCT03818009: Effect of General Anesthesia on Early Postoperative Cognitive Function in Cesarean Section
Official title: Effect of General Anesthesia on Early Postoperative Cognitive Dysfunction in Elective Versus Emergency Cesarean Section
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Anesthesia Morbidity
Cesarean Section Complications
Keywords: Cognitive function postoperative
Lead sponsor: Beni-Suef University
Sponsor class: OTHER
First posted: 2019-01-28
Enrollment: 58
Sex: FEMALE
Minimum age (years): 25
Maximum age (years): 35
Standard ages: ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: Women in reproductive age period between 25 and 35 years booked for an elective or emergency cesarean section.

Brief summary: Cognitive dysfunction is the impairment of the mental process of perception, memory and information processing. The preoperative cognitive state is important, as mild cognitive impairment may be worsened following a cesarean section. Our study will aim to assess the incidence of early cognitive dysfunction after elective and emergent cesarean section under general anesthesia.

Detailed description: Mechanisms that lead to cognitive decline after anesthesia and surgery remain still unclear and mixed. Some studies suggested that an important role is played by the immune response to surgery. The inflammatory response could contribute to the development of postoperative cognitive decline (POCD0 through secretion of cortisol, cytokines, and other inflammatory mediators. Comparing the effects of general and spinal anesthesia on pregnant patients undergoing an elective cesarean section, found no cognitive change after both anesthesias. Our observational comparative study will be carried out at Beni Suef University Hospital. We will compare early cognitive functions undergoing general anesthesia in patients undergoing elective and emergency cesarean section.

Eligibility criteria: Inclusion Criteria:

* Women in reproductive age period between 25 and 35 years
* Women booked for an elective or emergency cesarean section.

Exclusion Criteria:

* Mental disorder preoperative
* Medical conditions ( as Hypertension or diabetes or cardiac diseases)

Primary outcomes:
measure: postoperative cognitive decline (POCD)
timeFrame: 3 hours postoperative
Secondary outcomes:
measure: impaired performance on intellectual tasks
timeFrame: 3 days postoperative
Other outcomes:
Locations:
city: Cairo
country: Egypt
facility: Nesreen Abdel Fattah Abdullah Shehata
Study officials:
References:
citation: Rasmussen LS, O'Brien JT, Silverstein JH, Johnson TW, Siersma VD, Canet J, Jolles J, Hanning CD, Kuipers HM, Abildstrom H, Papaioannou A, Raeder J, Yli-Hankala A, Sneyd JR, Munoz L, Moller JT; ISPOCD2 Investigators. Is peri-operative cortisol secretion related to post-operative cognitive dysfunction? Acta Anaesthesiol Scand. 2005 Oct;49(9):1225-31. doi: 10.1111/j.1399-6576.2005.00791.x.
citation: Wan Y, Xu J, Ma D, Zeng Y, Cibelli M, Maze M. Postoperative impairment of cognitive function in rats: a possible role for cytokine-mediated inflammation in the hippocampus. Anesthesiology. 2007 Mar;106(3):436-43. doi: 10.1097/00000542-200703000-00007.