Clinical trial NCT00579618: Ascertainment of Saliva or Blood Samples For Genetic Epidemiology Studies of Cancer and Aging
Official title: Ascertainment of Saliva or Blood Samples For Genetic Epidemiology Studies of Cancer and Aging
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Non-cancer Affected Volunteers
Keywords: non-cancer affected volunteers
aged 60 years or older
Lead sponsor: Memorial Sloan Kettering Cancer Center
Sponsor class: OTHER
Collaborators: name: Susan G. Komen Breast Cancer Foundation
name: Beth Abraham
name: Gurwin Jewish Nursing & Rehabilitation Center
name: Hebrew Home at Riverdale
name: Jewish Home & Hospital Lifecare System
name: Margaret Tietz Nursing and Rehabilitation Center
name: Metropolitan Jewish Health System
name: Northern Services Group
name: Parker Jewish Institute
name: Lenox Hill Neighborhood House
name: JASA at Temple Emanuel of Parkchester Senior Center
name: Van Cortlandt Village Senior Center
First posted: 2007-12-24
Enrollment: 53
Sex: ALL
Minimum age (years): 60
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Nursing homes, senior centers, health fairs or other community organizations.

Brief summary: The purpose of this study is to help us learn more about the roles of genes in cancers. Genes are short pieces of DNA which determine the inherited characteristics that distinguish one individual from another. This study will look at how some genes might raise or lower the chance some people may develop cancer. The sample collection will help generate the materials needed for this study.

Detailed description: This is a protocol to obtain saliva or blood samples from non-cancer affected volunteers aged 60 years or older, without a history of cancer other than non-melanoma skin cancer. These samples will be used in a genomic approach to elucidate novel pathways of cancer predisposition.

Eligibility criteria: Inclusion Criteria:

* Eligible subjects must be non-cancer affected volunteers of either gender who are 60 years of age or older at the time of saliva/blood donation.
* Subjects will self-identify religion and country of origin of grandparents.
* Volunteers will have (by self report) no history of cancer other than nonmelanoma skin cancer. It is recognized that there may be some errors in self report, however, the literature reports a very low error rate for self reported disease reporting for cancer as assessed by interview.

Exclusion Criteria:

* Subjects with mental impairment will be excluded from this study.

Primary outcomes:
measure: obtain saliva or blood from non-cancer volunteers, 60 years or older to carry out anonymous genetic epidemiology studies related to resistance to cancer in elderly.
timeFrame: conclusion of the study
Secondary outcomes:
measure: samples perform high density genomic scans & candid gene studies carriers specif BRCA found mutat who haven't been affect by breast cancer & old than 60 find genetic cofactor may modify a predispo breast ca confer by germline mutation in BRCA1 & BRCA2.
timeFrame: conclusion of the study
Other outcomes:
Locations:
city: New York
country: United States
facility: Memorial Sloan Kettering Cancer Center
state: New York
Study officials:
affiliation: Memorial Sloan Kettering Cancer Center
name: Kenneth Offit, MD, MPH
role: PRINCIPAL_INVESTIGATOR
References: