Clinical trial NCT01358877: A Study of Pertuzumab in Addition to Chemotherapy and Trastuzumab as Adjuvant Therapy in Participants With Human Epidermal Growth Receptor 2 (HER2)-Positive Primary Breast Cancer
Official title: A Randomized Multicenter, Double-Blind, Placebo-Controlled Comparison of Chemotherapy Plus Trastuzumab Plus Placebo Versus Chemotherapy Plus Trastuzumab Plus Pertuzumab as Adjuvant Therapy in Patients With Operable HER2-Positive Primary Breast Cancer
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE3
Conditions: Breast Cancer
Lead sponsor: Hoffmann-La Roche
Sponsor class: INDUSTRY
Collaborators: name: Genentech, Inc.
name: Breast International Group
First posted: 2011-05-24
Enrollment: 4804
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: This randomized, double-blind, placebo-controlled, two-arm study will assess the safety and efficacy of pertuzumab in addition to chemotherapy plus trastuzumab as adjuvant therapy in participants with operable HER2-positive primary breast cancer. This study will be carried out in collaboration with the Breast International Group (BIG).


Eligibility criteria: Inclusion Criteria:

* Non-metastatic operable primary invasive HER2-positive carcinoma of the breast that is histologically confirmed, and adequately excised
* Eastern Cooperative Oncology Group (ECOG) performance status less than or equal to (\</=) 1
* Known hormone receptor status (estrogen receptor and progesterone receptor)
* The interval between definitive surgery for breast cancer and the first dose of chemotherapy must be no more than 8 weeks (56 days). The first cycle of chemotherapy must be administered within 7 days of randomization or on Day 56, whichever occurs first
* Baseline left ventricular ejection fraction (LVEF) greater than or equal to (\>/=) 55 percent (%) measured by echocardiogram (ECHO) or Multiple-Gated Acquisition (MUGA) Scan
* Confirmed HER2 positive status
* Completion of all necessary baseline laboratory and radiologic investigations prior to randomization
* Women of childbearing potential and male participants with partners of childbearing potential must agree to use effective contraception (as defined by the protocol) by the participant and/or partner for the duration of the study treatment and for at least 7 months after the last dose of study drug

Exclusion Criteria:

* History of any prior (ipsi- and/or contralateral) invasive breast cancer
* History of non-breast malignancies within the 5 years prior to study entry, except for carcinoma in situ of the cervix, carcinoma in situ of the colon, melanoma in situ, and basal cell and squamous cell carcinomas of the skin
* Any "clinical" T4 tumor as defined by primary tumor/regional lymph nodes/distant metastasis (TNM), including inflammatory breast cancer
* Any node-negative tumor
* Any previous systemic chemotherapy for cancer or radiotherapy for cancer
* Prior use of anti-HER2 therapy for any reason or other prior biologic or immunotherapy for cancer
* Concurrent anti-cancer treatment in another investigational trial
* Serious cardiac or cardiovascular disease or condition
* Other concurrent serious diseases that may interfere with planned treatment including severe pulmonary conditions/illness
* Abnormal laboratory tests immediately prior to randomization
* Pregnant or lactating women
* Sensitivity to any of the study medications or any of the ingredients or excipients of these medications

Primary outcomes:
measure: Percentage of Participants With Invasive Disease-Free Survival (IDFS) Event (Excluding Second Primary Non-Breast Cancer [SPNBC]), as Assessed Using Radiologic, Histologic Examinations or Laboratory Findings
timeFrame: Randomization to the first occurrence of IDFS event (excluding SPNBC) (until data cut-off date 19 December 2016, up to maximum length of follow-up of 59 months)
measure: Kaplan-Meier Estimate of the Percentage of Participants Who Were IDFS Event-Free (Excluding SPNBC) at Year 3, as Assessed Using Radiologic, Histologic Examinations or Laboratory Findings
timeFrame: 3 years
Secondary outcomes:
measure: Percentage of Participants With IDFS Event (Including SPNBC), as Assessed Using Radiologic, Histologic Examinations or Laboratory Findings
timeFrame: Randomization to the first occurrence of IDFS event (including SPNBC) (until data cut-off date 19 December 2016, up to maximum length of follow-up of 59 months)
measure: Kaplan-Meier Estimate of the Percentage of Participants Who Were IDFS Event-Free (Including SPNBC) at Year 3, as Assessed Using Radiologic, Histologic Examinations or Laboratory Findings
timeFrame: 3 years
measure: Percentage of Participants With Disease-Free Survival (DFS) Event, as Assessed Using Radiologic, Histologic Examinations or Laboratory Findings
timeFrame: Randomization to the first occurrence of DFS event (until data cut-off date 19 December 2016, up to maximum length of follow-up of 59 months)
measure: Kaplan-Meier Estimate of the Percentage of Participants Who Were DFS Event-Free at Year 3, as Assessed Using Radiologic, Histologic Examinations or Laboratory Findings
timeFrame: 3 years
measure: Percentage of Participants Who Died
timeFrame: Randomization until death due to any cause (until data cut-off date 19 December 2016, up to maximum length of follow-up of 59 months)
measure: Kaplan-Meier Estimate of the Percentage of Participants Who Were Alive at Year 3
timeFrame: 3 years
measure: Percentage of Participants With Recurrence-Free Interval (RFI) Event, as Assessed Using Radiologic, Histologic Examinations or Laboratory Findings
timeFrame: Randomization until local, regional or distant breast cancer recurrence (until data cut-off date 19 December 2016, up to maximum length of follow-up of 59 months)
measure: Kaplan-Meier Estimate of the Percentage of Participants Who Were RFI Event-Free at Year 3, as Assessed Using Radiologic, Histologic Examinations or Laboratory Findings
timeFrame: 3 years
measure: Percentage of Participants With Distant Recurrence-Free Interval (DRFI) Event, as Assessed Using Radiologic, Histologic Examinations or Laboratory Findings
timeFrame: Randomization until distant breast cancer recurrence (until data cut-off date 19 December 2016, up to maximum length of follow-up of 59 months)
measure: Kaplan-Meier Estimate of the Percentage of Participants Who Were DRFI Event-Free at Year 3, as Assessed Using Radiologic, Histologic Examinations or Laboratory Findings
timeFrame: 3 years
measure: Percentage of Participants With Primary Cardiac Event
timeFrame: Baseline until data cut-off date 19 December 2016 (up to maximum length of follow-up of 59 months)
measure: Percentage of Participants With Secondary Cardiac Event
timeFrame: Baseline until data cut-off date 19 December 2016 (up to maximum length of follow-up of 59 months)
measure: Change From Baseline in LVEF to Worst Post-Baseline Value
timeFrame: Baseline until data cut-off date 19 December 2016 (up to maximum length of follow-up of 59 months)
measure: Change From Baseline in European Organization for Research and Treatment of Cancer Quality of Life Questionnaire - Core 30 (EORTC QLQ-C30) Global Health Status (GHS) Scale Score
timeFrame: Baseline, Weeks 13, 25; end of treatment (EOT, 28 days after the last dose, up to Week 56); Follow-up (FU) Months 18, 24, 36
measure: Change From Baseline in EORTC QLQ-C30 Functioning Subscale Scores
timeFrame: Baseline, Weeks 13, 25; EOT (28 days after the last dose, up to Week 56); FU Months 18, 24, 36
measure: Change From Baseline in EORTC QLQ-C30 Disease/Treatment-Related Symptoms Subscale Scores
timeFrame: Baseline, Weeks 13, 25; EOT (28 days after the last dose, up to Week 56); FU Months 18, 24, 36
measure: Change From Baseline in EORTC QLQ-C30 Financial Difficulties Subscale Scores
timeFrame: Baseline, Weeks 13, 25; EOT (28 days after the last dose, up to Week 56); FU Months 18, 24, 36
measure: Change From Baseline in European Organisation for Research and Treatment of Cancer - Breast Cancer Module Quality of Life (EORTC QLQ-BR23) Functional Scale Score
timeFrame: Baseline, Weeks 13, 25; EOT (28 days after the last dose, up to Week 56); FU Months 18, 24, 36
measure: Change From Baseline in EORTC QLQ-BR23 Symptom Scale Score
timeFrame: Baseline, Weeks 13, 25; EOT (28 days after the last dose, up to Week 56); FU Months 18, 24, 36
measure: Percentage of Participants With Response for European Quality of Life-5 Dimensions-3 Level (EQ-5D-3L) Questionnaire: Mobility Domain
timeFrame: Baseline, Weeks 13, 25; EOT (28 days after the last dose, up to Week 56); FU Months 18, 24, 36
measure: Percentage of Participants With Response for EQ-5D-3L Questionnaire: Self-Care Domain
timeFrame: Baseline, Weeks 13, 25; EOT (28 days after the last dose, up to Week 56); FU Months 18, 24, 36
measure: Percentage of Participants With Response for EQ-5D-3L Questionnaire: Usual Activities Domain
timeFrame: Baseline, Weeks 13, 25; EOT (28 days after the last dose, up to Week 56); FU Months 18, 24, 36
measure: Percentage of Participants With Response for EQ-5D-3L Questionnaire: Pain/Discomfort Domain
timeFrame: Baseline, Weeks 13, 25; EOT (28 days after the last dose, up to Week 56); FU Months 18, 24, 36
measure: Percentage of Participants With Response for EQ-5D-3L Questionnaire: Anxiety/Depression Domain
timeFrame: Baseline, Weeks 13, 25; EOT (28 days after the last dose, up to Week 56); FU Months 18, 24, 36
measure: Trough Serum Concentration (Cmin) of Pertuzumab
timeFrame: Cycles 1, 10 and 15 (Cycle length=21 days)
measure: Cmin of Trastuzumab
timeFrame: Cycles 1, 10 and 15 (Cycle length=21 days)
measure: Peak Serum Concentration (Cmax) of Pertuzumab
timeFrame: Cycles 1, 10 and 15 (Cycle length=21 days)
measure: Cmax of Trastuzumab
timeFrame: Cycles 1, 10 and 15 (Cycle length=21 days)
Other outcomes:
Locations:
city: Scottsdale
country: United States
facility: HonorHealth Research Institute ? Bisgrove
state: Arizona
city: Everett
country: United States
facility: Providence Regional Medical Center
state: California
city: Greenbrae
country: United States
facility: Marin Cancer Care Inc
state: California
city: Hayward
country: United States
facility: Kaiser Permanente - Hayward
state: California
city: La Jolla
country: United States
facility: UCSD Moores Cancer Center
state: California
city: Los Angeles
country: United States
facility: Cedars-Sinai Medical Center
state: California
city: Oakland
country: United States
facility: Kaiser Permanente - Oakland
state: California
city: Roseville
country: United States
facility: Kaiser Permanente - Roseville
state: California
city: Sacramento
country: United States
facility: Sutter Cancer Center
state: California
city: Sacramento
country: United States
facility: Kaiser Permanente Sacramento Medical Center
state: California
city: San Diego
country: United States
facility: Southern California Kaiser Permanente
state: California
city: San Francisco
country: United States
facility: K. Permanente - San Fransisco
state: California
city: San Jose
country: United States
facility: K. Permanente - San Jose
state: California
city: Santa Clara
country: United States
facility: K. Permanente - Santa Clara
state: California
city: South San Francisco
country: United States
facility: K. Permanente - S. San Fran
state: California
city: Vallejo
country: United States
facility: Kaiser Permanente; Oncology Clinical Trials
state: California
city: Walnut Creek
country: United States
facility: K. Permanente - Walnut Creek
state: California
city: Littleton
country: United States
facility: Rocky Mountain Cancer Center - Denver
state: Colorado
city: Wheat Ridge
country: United States
facility: Lutheran Hematology &Oncology
state: Colorado
city: Norwich
country: United States
facility: Eastern Ct Hema/Onco Assoc; Dept of Oncology
state: Connecticut
city: Washington
country: United States
facility: Washington Cancer Institute at MedStar Washington Hospital Center.
state: District of Columbia
city: Washington
country: United States
facility: Georgetown U; Lombardi Comp Can
state: District of Columbia
city: Fort Myers
country: United States
facility: Florida Cancer Specialists; SCRI
state: Florida
city: Hollywood
country: United States
facility: Memorial Cancer Institute
state: Florida
city: Jacksonville
country: United States
facility: Mayo Clinic-Jacksonville
state: Florida
city: Jacksonville
country: United States
facility: Cancer Specialists; North Florida ;Jacksonville (AC Skinner Pkwy)
state: Florida
city: Ocala
country: United States
facility: Ocala Oncology Center
state: Florida
city: Pembroke Pines
country: United States
facility: Memorial Breast Cancer Center
state: Florida
city: Port Saint Lucie
country: United States
facility: Hematology Oncology Associates of the Treasure Coast
state: Florida
city: Saint Petersburg
country: United States
facility: Florida Cancer Specialists; Saint Petersburg
state: Florida
city: West Palm Beach
country: United States
facility: Florida Cancer Specialists, Research Department
state: Florida
city: Albany
country: United States
facility: Phoebe Putney Memorial Hospital
state: Georgia
city: Atlanta
country: United States
facility: Georgia Cancer Specialists
state: Georgia
city: Marietta
country: United States
facility: Northwest Georgia Oncology Centers PC - Marietta
state: Georgia
city: Post Falls
country: United States
facility: Kootenai Cancer Center
state: Idaho
city: Chicago
country: United States
facility: Rush University Medical Center
state: Illinois
city: Chicago
country: United States
facility: Uni of Chicago
state: Illinois
city: Harvey
country: United States
facility: Ingalls Memorial Hospital
state: Illinois
city: Maywood
country: United States
facility: Loyola University Med Center
state: Illinois
city: Naperville
country: United States
facility: Edward Cancer Center Naperville
state: Illinois
city: Peoria
country: United States
facility: Illinois Cancer Care
state: Illinois
city: Plainfield
country: United States
facility: Edward Cancer Center Plainfield
state: Illinois
city: Quincy
country: United States
facility: Quincy Medical Group; Canc Ctr at Blessing Hosp
state: Illinois
city: Urbana
country: United States
facility: Carle Foundation
state: Illinois
city: Iowa City
country: United States
facility: University of Iowa
state: Iowa
city: Wichita
country: United States
facility: Cancer Center of Kansas
state: Kansas
city: Lafayette
country: United States
facility: Cancer Center of Acadiana at Lafayette General
state: Louisiana
city: Brewer
country: United States
facility: Cancer Care of Maine
state: Maine
city: Scarborough
country: United States
facility: New England Cancer Specialists
state: Maine
city: Baltimore
country: United States
facility: Mercy Medical Center
state: Maryland
city: Baltimore
country: United States
facility: Weinberg CA Inst Franklin Sq
state: Maryland
city: Bethesda
country: United States
facility: Maryland Oncology & Hematology, PA
state: Maryland
city: Boston
country: United States
facility: Massachusetts General Hospital.
state: Massachusetts
city: Boston
country: United States
facility: Boston Medical Center
state: Massachusetts
city: Boston
country: United States
facility: Dana Farber Cancer Institute at Faulkner Hospital
state: Massachusetts
city: Boston
country: United States
facility: Beth Israel Deac Med Ctr; East Campus Rsch Pharmacy
state: Massachusetts
city: Boston
country: United States
facility: Dana Farber Can Ins
state: Massachusetts
city: Pittsfield
country: United States
facility: Berkshire Hematology, Oncology Pc
state: Massachusetts
city: Grand Rapids
country: United States
facility: Grand Rapids Clinical Oncology Program
state: Michigan
city: Kalamazoo
country: United States
facility: West Michigan Cancer Center
state: Michigan
city: Edina
country: United States
facility: Southdale Cancer Clinic
state: Minnesota
city: Saint Cloud
country: United States
facility: Coborn Cancer Center
state: Minnesota
city: Saint Louis Park
country: United States
facility: Metro-Minnesota Community Oncology Research Consortium
state: Minnesota
city: Jackson
country: United States
facility: Jackson Oncology Associates, PLLC
state: Mississippi
city: Kansas City
country: United States
facility: University of Missouri-Columbia; Ellis Fischel Cancer Center
state: Missouri
city: Saint Louis
country: United States
facility: Washington University School of Medicine
state: Missouri
city: Saint Louis
country: United States
facility: Heartland CCOP/Missouri Baptist Medical Center
state: Missouri
city: Lincoln
country: United States
facility: Cancer Alliance of Nebraska
state: Nebraska
city: Omaha
country: United States
facility: Cancer Alliance of Nebraska
state: Nebraska
city: Lebanon
country: United States
facility: Dartmouth Hitchcock Med Center
state: New Hampshire
city: Livingston
country: United States
facility: Saint Barnabas Medical Center
state: New Jersey
city: Albany
country: United States
facility: New York Oncology Hematology, P.C.
state: New York
city: Bronx
country: United States
facility: Montefiore Medical Center
state: New York
city: Buffalo
country: United States
facility: Roswell Park Cancer Inst.
state: New York
city: New York
country: United States
facility: Mount Sinai Beth Israel Medical Center
state: New York
city: New York
country: United States
facility: Mount Sinai Beth Israel Comprehensive Cancer Center
state: New York
city: New York
country: United States
facility: Mount Sinai West
state: New York
city: New York
country: United States
facility: Memorial Sloan Kettering Cancer Center
state: New York
city: Syracuse
country: United States
facility: SUNY Upstate Medical University
state: New York
city: Chapel Hill
country: United States
facility: University of North Carolina-Chapel Hill
state: North Carolina
city: Hickory
country: United States
facility: Carolina Oncology Specialists, PA - Hickory
state: North Carolina
city: Centerville
country: United States
facility: Dayton Clinical Oncology Prog
state: Ohio
city: Cincinnati
country: United States
facility: Oncology Hematology Care Inc
state: Ohio
city: Columbus
country: United States
facility: The Mark H. Zangmeister Ctr; Mid Ohio Onc/Hem Inc.
state: Ohio
city: Toledo
country: United States
facility: Toledo Clinic Cancer Center
state: Ohio
city: Portland
country: United States
facility: Northwest Cancer Specialists - Portland (NE Hoyt St)
state: Oregon
city: Philadelphia
country: United States
facility: Abramson Cancer Center; Univ of Pennsylvania
state: Pennsylvania
city: Philadelphia
country: United States
facility: Albert Einstein Healthcare Network ; Cancer Center
state: Pennsylvania
city: Pittsburgh
country: United States
facility: Magee Womens Hospital
state: Pennsylvania
city: Charleston
country: United States
facility: Charleston Oncology, P .A
state: South Carolina
city: Charleston
country: United States
facility: Roper Bon Secours St. Francis Cancer Center
state: South Carolina
city: Columbia
country: United States
facility: South Carolina Oncology Associates - SCRI
state: South Carolina
city: Greenville
country: United States
facility: Cancer Centers of the Carolina; Eastside Medical Center
state: South Carolina
city: Sioux Falls
country: United States
facility: Sanford USD School of Medicine
state: South Dakota
city: Chattanooga
country: United States
facility: Tennessee Oncology , PLLC - Chattanooga
state: Tennessee
city: Nashville
country: United States
facility: Tennessee Oncology - Nashville
state: Tennessee
city: Nashville
country: United States
facility: Vanderbilt Breast Center at One Hundred Oaks
state: Tennessee
city: Dallas
country: United States
facility: Texas Oncology-Medical City Dallas
state: Texas
city: Dallas
country: United States
facility: Texas Oncology - DFW at Dallas Presbyterian Hospital
state: Texas
city: Dallas
country: United States
facility: Texas Oncology - DFW
state: Texas
city: El Paso
country: United States
facility: Texas Oncology-El Paso Cancer Treatment Center Grandview
state: Texas
city: Fort Worth
country: United States
facility: Texas Oncology - DFW Fort Worth
state: Texas
city: Fort Worth
country: United States
facility: The Center for Cancer and Blood Disorders - Fort Worth
state: Texas
city: Garland
country: United States
facility: Texas Oncology, P.A. - Garland
state: Texas
city: Houston
country: United States
facility: Texas Oncology - Houston (Gessner)
state: Texas
city: Irving
country: United States
facility: Texas Oncology-Tyler
state: Texas
city: New Braunfels
country: United States
facility: Cancer Care Centers of South Texas-HOAST - San Antonio
state: Texas
city: Plano
country: United States
facility: Texas Oncology - DFW Plano
state: Texas
city: Ogden
country: United States
facility: Community Cancer Trials of Utah
state: Utah
city: Bristol
country: United States
facility: Wellmonth Physician Services
state: Virginia
city: Richmond
country: United States
facility: Virginia Cancer Institute
state: Virginia
city: Walla Walla
country: United States
facility: Providence St. Mary Regional Cancer Center
state: Washington
city: Morgantown
country: United States
facility: West Virginia University Hospitals Inc
state: West Virginia
city: Green Bay
country: United States
facility: Green Bay Oncology/St. Mary?s Hospital
state: Wisconsin
city: Marshfield
country: United States
facility: Marshfield Clinic
state: Wisconsin
city: San Miguel de Tucuman
country: Argentina
facility: Centro Medico San Roque
city: Santa Fe
country: Argentina
facility: Isis Centro Especializado de Luces; Oncology
city: Lismore
country: Australia
facility: Lismore Base Hospital; Cancer Care & Haematology Unit
state: New South Wales
city: Sydney
country: Australia
facility: Mater Misericordiae Hospital; Chemotherapy Cottage
state: New South Wales
city: Waratah
country: Australia
facility: Newcastle Mater Misericordiae Hospital; Oncology
state: New South Wales
city: Westmead
country: Australia
facility: Westmead Hospital; Medical Oncology and Pallative Care
state: New South Wales
city: Auchenflower
country: Australia
facility: Wesley Medical Centre; Clinic For Haematology and Oncology
state: Queensland
city: Brisbane
country: Australia
facility: Mater Hospital; Oncology
state: Queensland
city: Adelaide
country: Australia
facility: Royal Adelaide Hospital; Oncology
state: South Australia
city: Hobart
country: Australia
facility: Royal Hobart Hospital; Medical Oncology
state: Tasmania
city: Clayton
country: Australia
facility: Monash Medical Centre; Oncology
state: Victoria
city: Geelong
country: Australia
facility: Geelong Hospital; Andrew Love Cancer Centre
state: Victoria
city: Heidelberg
country: Australia
facility: Austin Hospital; Medical Oncology
state: Victoria
city: Melbourne
country: Australia
facility: Peter Maccallum Cancer Institute; Medical Oncology
state: Victoria
city: Perth
country: Australia
facility: Sir Charles Gairdner Hospital; Medical Oncology
state: Western Australia
city: Graz
country: Austria
facility: Lkh-Univ. Klinikum Graz; Klinik Für Innere Medizin I
city: Innsbruck
country: Austria
facility: Tiroler Landeskrankenanstalten Ges.M.B.H.; Abt. Für Gynäkologie
city: Linz
country: Austria
facility: Ordensklinikum Linz Barmherzige Schwestern; Abt. fur Innere Medizin 1
city: Rankweil
country: Austria
facility: Lhk Feldkirch; Interne Medizin Abt.
city: Salzburg
country: Austria
facility: Lkh Salzburg - Univ. Klinikum Salzburg; Iii. Medizinische Abt.
city: St Veit An Der Glan
country: Austria
facility: A. Ö. Krankenhaus Der Barmherzigen Brüder; Interne Abt.
city: Vöcklabruck
country: Austria
facility: Lkh Vöcklabruck; I. Abt. Für Innere Medizin
city: Wels
country: Austria
facility: Klinikum Kreuzschwestern Wels; Iii. Interne Abt.
city: Wien
country: Austria
facility: Medizinische Universität Wien; Univ.Klinik für Frauenheilkunde - Klinik für Gynäkologie
city: Wien
country: Austria
facility: Medizinische Universität Wien; Univ.Klinik für Innere Medizin I - Abt. für Onkologie
city: Wien
country: Austria
facility: Krankenhaus Der Stadt Wien-Hietzing; Abt. Für Gynäkologie U. Geburtshilfe
city: Anderlecht
country: Belgium
facility: Institut Jules Bordet
city: Charleroi
country: Belgium
facility: GHdC Site Notre Dame
city: Edegem
country: Belgium
facility: UZ Antwerpen
city: Hasselt
country: Belgium
facility: Jessa Zkh (Campus Virga Jesse)
city: Kortrijk
country: Belgium
facility: AZ Groeninge
city: Leuven
country: Belgium
facility: UZ Leuven Gasthuisberg
city: Liège
country: Belgium
facility: CHU Sart-Tilman
city: Namur
country: Belgium
facility: Clinique Ste-Elisabeth
city: Wilrijk
country: Belgium
facility: Sint Augustinus Wilrijk
city: Sofia
country: Bulgaria
facility: UMHAT Tsaritsa Yoanna - ISUL; Clinic of Oncotherapy
city: Sofia
country: Bulgaria
facility: SHATO - Sofia
city: Varna
country: Bulgaria
facility: SHATOD Dr. Marko Antonov Markov-Varna, EOOD
city: Calgary
country: Canada
facility: Tom Baker Cancer Centre; Dept of Medicine
state: Alberta
city: Edmonton
country: Canada
facility: Cross Can Inst
state: Alberta
city: Kelowna
country: Canada
facility: BC Cancer Agency, CSI
state: British Columbia
city: Surrey
country: Canada
facility: BC Cancer ? Surrey
state: British Columbia
city: Vancouver
country: Canada
facility: BCCA-Vancouver Cancer Centre
state: British Columbia
city: Victoria
country: Canada
facility: Bcca - Vancouver Island Cancer Centre; Oncology
state: British Columbia
city: Winnipeg
country: Canada
facility: CancerCare Manitoba; Neuro-Oncology
state: Manitoba
city: Saint John
country: Canada
facility: Atlantic Health Science Corporation; Saint John Regional Hospital Facility
state: New Brunswick
city: Halifax
country: Canada
facility: Queen Elizabeth II Health Sciences Centre; Oncology
state: Nova Scotia
city: Hamilton
country: Canada
facility: Hamilton Health Sciences - Juravinski Cancer Centre
state: Ontario
city: Kingston
country: Canada
facility: Cancer Centre of Southeastern Ontario; Kingston General Hospital
state: Ontario
city: London
country: Canada
facility: London Health Sciences Centre
state: Ontario
city: Mississauga
country: Canada
facility: Credit Valley Hospital/Carlo Fidani Peel Regional Cancer Centre
state: Ontario
city: Newmarket
country: Canada
facility: Southlake Regional Health Center
state: Ontario
city: Ottawa
country: Canada
facility: Ottawa Regional Cancer Centre
state: Ontario
city: St. Catharines
country: Canada
facility: Niagara Health Systems - St. Catherines General Site; Niagara Health System-St. Catharines Site
state: Ontario
city: Sudbury
country: Canada
facility: Northeastern Ontario; Regional Cancer Centre
state: Ontario
city: Toronto
country: Canada
facility: Sunnybrook Odette Cancer Centre
state: Ontario
city: Toronto
country: Canada
facility: Mount Sinai Hospital
state: Ontario
city: Toronto
country: Canada
facility: Princess Margaret Cancer Center
state: Ontario
city: Montreal
country: Canada
facility: Hopital Maisonneuve- Rosemont; Oncology
state: Quebec
city: Montreal
country: Canada
facility: Chum Hopital Notre Dame; Centre D'Oncologie
state: Quebec
city: Montreal
country: Canada
facility: Hopital Sacre-Coeur Research Centre
state: Quebec
city: Quebec City
country: Canada
facility: Hopital du Saint Sacrement
state: Quebec
city: Regina
country: Canada
facility: Allan Blair Cancer Centre
state: Saskatchewan
city: Providencia
country: Chile
facility: INTOP
city: Santiago
country: Chile
facility: Fundacion Arturo Lopez Perez
city: Beijing
country: China
facility: Cancer Hospital Chinese Academy of Medical Sciences.
city: Beijing
country: China
facility: The Affiliated Hospital of Military Medical Sciences(The 307th Hospital of Chinese PLA)
city: Changchun
country: China
facility: the First Hospital of Jilin University
city: Changchun
country: China
facility: Jilin Cancer Hospital
city: Changsha
country: China
facility: Hu Nan Provincial Cancer Hospital
city: Chengdu
country: China
facility: Sichuan Provincial People's Hospital
city: Fuzhou City
country: China
facility: Fujian Medical University Union Hospital
city: Fuzhou
country: China
facility: The 900th Hospital of PLA joint service support force
city: Guangzhou City
country: China
facility: Sun Yet-sen University Cancer Center
city: Guangzhou
country: China
facility: Guangdong General Hospital
city: Hangzhou
country: China
facility: The First Affiliated Hospital of College of Medicine, Zhejiang University
city: Harbin
country: China
facility: Harbin Medical University Cancer Hospital
city: Nanchang
country: China
facility: The 1st Affiliated Hospital of Nanchang Unversity
city: Shanghai City
country: China
facility: Fudan University Shanghai Cancer Center
city: Shanghai
country: China
facility: Shanghai Jiao Tong University School of Medicine (SJTUSM) - Ruijin Hospital (GuangCi Hospital)
city: Shanghai
country: China
facility: Shanghai First People's Hospital
city: Shanghai
country: China
facility: Changhai Hospital of Shanghai
city: Shijiazhuang
country: China
facility: Hebei Medical University Fourth Hospital;(Tumor Hospital of Hebei Province)
city: Wuhan
country: China
facility: Xiehe Hospital, Tongji Medical College Huazhong University of Science & Technology
city: Wuhan
country: China
facility: Tongji Hosp, Tongji Med. Col, Huazhong Univ. of Sci. & Tech
city: Wuhan
country: China
facility: Hubei Cancer Hospital
city: Bogota
country: Colombia
facility: Inst. Nacional de Cancerologia; Clinica de Seno
city: Bogota
country: Colombia
facility: Fundacion Cardioinfantil
city: Medellin
country: Colombia
facility: Hospital Pablo Tobon Uribe
city: Monteria
country: Colombia
facility: Oncomedica S.A.
city: Split
country: Croatia
facility: Uni Hospital Split; Oncology & Radiotherapy
city: Varazdin
country: Croatia
facility: General Hospital Varazdin
city: Zagreb
country: Croatia
facility: Clinical Hospital Centre Zagreb
city: Brno
country: Czechia
facility: Masarykuv onkologicky ustav
city: Hradec Kralove
country: Czechia
facility: Fakultni Nemocnice Hradec Kralove; Dept of Radiotherapy & Oncology
city: Olomouc
country: Czechia
facility: Fakultni nemocnice Olomouc; Onkologicka klinika
city: Pardubice
country: Czechia
facility: MULTISCAN, s.r.o., Radiologicke centrum Pardubice
city: Aalborg
country: Denmark
facility: Aalborg Universitetshospital; Onkologisk Afdeling
city: Esbjerg
country: Denmark
facility: Sydvestjysk Sygehus Esbjerg; Onkologisk afdeling
city: Herlev
country: Denmark
facility: Herlev Hospital; Afdeling for Kræftbehandling
city: Hillerod
country: Denmark
facility: Nordsjællands Hospital, Hillerød, Onkologisk Afdeling
city: København Ø
country: Denmark
facility: Rigshospitalet; Onkologisk Klinik
city: Naestved
country: Denmark
facility: Sjællands Universitetshospital, Næstved; Onkologisk Afdeling
city: Odense C
country: Denmark
facility: Odense Universitetshospital, Onkologisk Afdeling R
city: Roskilde
country: Denmark
facility: Sygehus Syd Roskilde; Onkologisk/haematologisk ambulatorium
city: Vejle
country: Denmark
facility: Vejle Sygehus; Onkologisk Afdeling
city: Salvador
country: El Salvador
facility: Hospital Oncologia; Oncology
city: San Salvador
country: El Salvador
facility: Hospital Diagnostico Escalón
city: Amiens
country: France
facility: Clinique De L Europe; Pmsi
city: Angers
country: France
facility: ICO Paul Papin; Oncologie Medicale.
city: Arras
country: France
facility: HOP Prive Arras Les Bonnettes; Chimiotherapie
city: Avignon
country: France
facility: Institut Sainte Catherine
city: Bezannes
country: France
facility: ICONE
city: Bordeaux
country: France
facility: Institut Bergonie; Oncologie
city: Bordeaux
country: France
facility: Polyclinique Bordeaux Nord
city: Brest
country: France
facility: Hopital Augustin Morvan; Federation De Cancerologie
city: Caen
country: France
facility: Centre Francois Baclesse; Recherche Clinique
city: Clermont Ferrand
country: France
facility: Centre Jean Perrin; Hopital De Jour
city: Dechy
country: France
facility: Centre Leonard De Vinci;Chimiotherapie
city: Dijon
country: France
facility: Centre Georges-François Lecler; Ctr de Lutte Contre le Canc
city: Grenoble
country: France
facility: Institut Daniel Hollard
city: La Roche Sur Yon
country: France
facility: Centre Hospitalier Departemental Les Oudairies
city: Le Havre
country: France
facility: Clinique des Ormeaux; Oncologie
city: Lille
country: France
facility: Centre Oscar Lambret; Cancerologie Gynecologique
city: Limoges
country: France
facility: Hopital Dupuytren; Oncologie Medicale
city: Lyon
country: France
facility: Centre Leon Berard; Departement Oncologie Medicale
city: Marseille
country: France
facility: Institut Paoli Calmettes; Oncologie Medicale
city: Montpellier
country: France
facility: Institut régional du Cancer Montpellier
city: Nancy
country: France
facility: Polyclinique De Gentilly; Hemodialyse
city: Nice
country: France
facility: Centre Antoine Lacassagne; Hopital De Jour A2
city: Nimes
country: France
facility: Institut de cancerologie du Gard
city: Paris
country: France
facility: Institut Curie; Oncologie Medicale
city: Paris
country: France
facility: Ch Pitie Salpetriere; Cmrr Ile De France Salpetriere
city: Perigueux
country: France
facility: Polyclinique Francheville; MED CHIMIOTHERAPIE RADIOTHERAPIE
city: Plerin
country: France
facility: Clinique Armoricaine Radiologie; Hopital de Jour
city: Poitiers
country: France
facility: Chu De Poitiers; Chu La Miletrie
city: Reims
country: France
facility: Institut Jean Godinot; Hopital De Jour
city: Rennes
country: France
facility: Centre Eugene Marquis; Unite Huguenin
city: Rouen
country: France
facility: Centre Henri Becquerel; Oncologie Medicale
city: Saint Herblain
country: France
facility: Ico Rene Gauducheau; Oncologie
city: Saint-Priest en Jarez
country: France
facility: ICL; Hematologie
city: St Cloud
country: France
facility: Centre Rene Huguenin; CONSULT SPECIALISEES
city: Strasbourg
country: France
facility: Institut d'oncologie de l'Orangerie; Chimiotherapie
city: Strasbourg
country: France
facility: Hopital Hautepierre; Hematologie Oncologie
city: Toulouse
country: France
facility: Institut Claudius Regaud; Departement Oncologie Medicale
city: Toulouse
country: France
facility: Clinique Pasteur; Pneumologie
city: Vandoeuvre-les-nancy
country: France
facility: Centre Alexis Vautrin; Oncologie Medicale
city: Villejuif
country: France
facility: Institut Gustave Roussy; Oncologie Medicale
city: Amberg
country: Germany
facility: Gesundheitszentrum St. Marien GmbH; Med. II, Hämatologie/Onkologie
city: Bad Nauheim
country: Germany
facility: Hochwaldkrankenhaus
city: Bergisch Gladbach
country: Germany
facility: Evang. Krankenhaus Frauenklinik
city: Berlin
country: Germany
facility: Praxisklinik Krebsheilkunde für Frauen / Brustzentrum (Dres. Kittel/Klare)
city: Berlin
country: Germany
facility: Praxis Dr. Schoenegg
city: Berlin
country: Germany
facility: HELIOS Klinikum Berlin-Buch; Klinik für Gynäkologie und Geburtshilfe
city: Berlin
country: Germany
facility: Frauenarzt-Zentrum Zehlendorf an der Teltower Eiche
city: Bielefeld
country: Germany
facility: Onkologische Schwerpunktpraxis Bielefeld; Haemotologie & Internistische onkologie
city: Bonn
country: Germany
facility: Universitätsklinikum Bonn; Zentrum für Geburtshilfe und Frauenheilkunde
city: Braunschweig
country: Germany
facility: Praxis Dr. Ralf Lorenz
city: Bremen
country: Germany
facility: Hämato-Onkologie im Medicum/Home
city: Böblingen
country: Germany
facility: Klinikum Sindelfingen-Böblingen; Frauenklinik
city: Chemnitz
country: Germany
facility: Klinikum Chemnitz gGmbH; Frauen- und Kinderklinik
city: Deggendorf
country: Germany
facility: DONAU ISAR Klinikum Deggendorf; Frauenklinik
city: Dortmund
country: Germany
facility: St. Johannes-Hospital
city: Dresden
country: Germany
facility: Universitätsklinikum "Carl Gustav Carus"; Frauenheilkunde und Geburtshilfe
city: Düsseldorf
country: Germany
facility: Universitätsklinikum Düsseldorf; Frauenklinik
city: Düsseldorf
country: Germany
facility: Luisenkrankenhaus GmbH & Co. KG., Brustzentrum
city: Erfurt
country: Germany
facility: Praxis für Hamatologie und Onkologie
city: Erlangen
country: Germany
facility: Universitätsklinikum Erlangen; Frauenklinik
city: Esslingen
country: Germany
facility: Klinikum Esslingen; Klinik für Frauenheilkunde und Geburtshilfe
city: Frankfurt am Main
country: Germany
facility: Hämatologisch-Onkologische Gemeinschaftspraxis am Bethanien-Krankenhaus
city: Frankfurt
country: Germany
facility: Klinik Johann Wolfgang von Goethe Uni; Klinik für Frauenheilkunde und Geburtshilfe
city: Frankfurt
country: Germany
facility: Städtische Kliniken Frankfurt am Main Höchst
city: Freiburg
country: Germany
facility: Praxis für Interdisziplinäre Onkologie und Hämatologie GbR
city: Fürth
country: Germany
facility: Dres.Jochen Wilke und Harald Wagner
city: Greifswald
country: Germany
facility: Universitätsklinikum Greifswald; Klinik für Frauenheilkunde und Brustzentrum
city: Halle
country: Germany
facility: Universitätsklinikum Halle (Saale); Universitätsklinik Und Poliklinik Für Gynäkologie
city: Hamburg
country: Germany
facility: Universitätsklinikum Hamburg-Eppendorf; Frauenklinik
city: Hameln
country: Germany
facility: SANA Klinikum Hameln-Pyrmont; Frauenklinik / Brustzentrum
city: Hannover
country: Germany
facility: Diakovere Henriettenstift, Frauenklinik
city: Hannover
country: Germany
facility: MVZ Onko Medical GmbH Hannover, Ralf Lohse (Geschäftsführer)
city: Heidelberg
country: Germany
facility: Nationales Centrum für Tumorerkrankungen (NCT) ; Gyn. Onk. Frauenklinik; Uniklinikum Heidelberg
city: Hildesheim
country: Germany
facility: Praxisgemeinschaft; Frauenärzte am Bahnhofsplatz
city: Homburg/Saar
country: Germany
facility: Universitätsklinikum des Saarlandes; Klinik f. Frauenheilkunden und Geburtshilfe
city: Karlsruhe
country: Germany
facility: ViDia Christliche Kliniken Karlsruhe, Vincentius-Diakonissen-Kliniken gAG; Frauenklinik
city: Kassel
country: Germany
facility: Elisabeth-Krankenhaus Brustzentrum
city: Kassel
country: Germany
facility: Klinikum Kassel GmbH; Klinik für Frauenheilkunde und Geburtshilfe
city: Kiel
country: Germany
facility: UNI-Klinikum Campus Kiel Klinik für Gynäkologie und Geburtshilfe
city: Koeln
country: Germany
facility: St. Elisabeth Krankenhaus Köln GmbH; Gynäkologie und Geburtshilfe
city: Köln
country: Germany
facility: Uniklinik Köln, Klinik und Poliklinik und Geburtshilfe; Brustzentrum Köln
city: Landshut
country: Germany
facility: Klinikum Landshut Frauenklinik
city: Leipzig
country: Germany
facility: Sankt Elisabeth Krankenhaus; Gynaekology
city: Ludwigsfelde
country: Germany
facility: Evangelisches Krankenhaus; Abt. Gynäkologie und Geburtshilfe
city: Lübeck
country: Germany
facility: Universitätsklinikum Schleswig-Holstein / Campus Lübeck; Klinik für Frauenheilkunde und Geburtshilfe
city: Mainz
country: Germany
facility: Universitätsmedizin Mainz; Klinik u. Poliklinik f. Geburtshilfe u. Frauenheilkunde
city: Muenchen
country: Germany
facility: Rotkreuzklinikum München; Frauenklinik
city: Mönchengladbach
country: Germany
facility: Brustzentrum Rhein-Ruhr Servicegesellschaft mbH
city: München
country: Germany
facility: Klinikum der Universität München; Frauenklinik - Onkologie II
city: München
country: Germany
facility: Klinikum rechts der Isar der TU München; Klinik und Poliklinik für Frauenheilkunde
city: Münster
country: Germany
facility: Universitätsklinikum Münster; Klinik für Frauenheilkunde und Geburtshilfe
city: Offenbach
country: Germany
facility: Sana Klinikum Offenbach GmbH; Klinik für Gynäkologie & Geburtshilfe
city: Oldenburg
country: Germany
facility: Medizinisches Versorgungszentrum am Klinikum Oldenburg GmbH
city: Ravensburg
country: Germany
facility: Hämatologisch/Onkologische Praxis Prof. Dr. Decker, Studienzentrum
city: Recklinghausen
country: Germany
facility: Oncologianova GmbH
city: Rosenheim
country: Germany
facility: RoMed Klinikum Rosenheim; Klinik für Gynäkologie und Geburtshilfe
city: Rostock
country: Germany
facility: Universitätsfrauen- und Poliklinik am Klinikum Suedstadt
city: Stade
country: Germany
facility: MVZ für Hämatologie, Onkologie, Strahlentherapie und Palliativmedizin -; Klinik Dr. Hancken
city: Trier
country: Germany
facility: Klinikum Mutterhaus der Borromaeerinnen gGmbH; Haematologie/Onkologie
city: Tübingen
country: Germany
facility: Universitätsklinik Tübingen; Frauenklinik
city: Ulm
country: Germany
facility: Universitätsklinikum Ulm Am Michelsberg; Frauenklinik
city: Velbert
country: Germany
facility: Dres. Arnd Nusch Naser Ali-Mohammad Kalhori und Werner Langer
city: Villingen-Schwenningen
country: Germany
facility: Schwarzwald-Baar Klinikum Klinik für Frauenheilkunde und Geburtshilfe
city: Wiesbaden
country: Germany
facility: St. Josefs-Hospital Wiesbaden
city: Witten
country: Germany
facility: Marien-Hospital Witten; Frauenklinik Brustzentrum
city: Würzburg
country: Germany
facility: Hämatologisch-Onkologische Schwerpunktpraxis Dres. Schlag & Schöttker
city: Guatemala City
country: Guatemala
facility: Grupo Angeles
city: Guatemala
country: Guatemala
facility: Centro Oncológico Sixtino / Centro Oncológico SA
city: Hong Kong
country: Hong Kong
facility: Queen Mary Hospital; Surgery
city: Hong Kong
country: Hong Kong
facility: Queen Mary Hospital; Dept of Medicine
city: Budapest
country: Hungary
facility: Semmelweis Egyetem Onkologiai Központ
city: Budapest
country: Hungary
facility: Orszagos Onkologiai Intezet; B Belgyogyaszati Osztaly
city: Budapest
country: Hungary
facility: Magyar Honvedseg Egeszsegugyi Kozpont; Fázis I-es Klinikai Farmakológiai Vizsgálóhely
city: Debrecen
country: Hungary
facility: Debreceni Egyetem, Klinikai Kozpont, Onkologiai Klinika
city: Gyor
country: Hungary
facility: Petz Aladar Megyei Oktato Korhaz; Oncoradiologia
city: Gyula
country: Hungary
facility: Békés Megyei Pándy Kálmán Kórház; Onkologiai tanszek
city: Kecskemet
country: Hungary
facility: Bács-Kiskun Vármegyei Oktatókórház
city: Szeged
country: Hungary
facility: Szegedi Tudomanyegyetem, AOK, Szent-Gyorgyi Albert Klinikai Kozpont, Onkoterapias Klinika
city: Veszprem
country: Hungary
facility: Veszprem Megyei Csolnoky; Ferenc Korhaz
city: Cork
country: Ireland
facility: Cork Uni Hospital; Oncology Dept
city: Dublin
country: Ireland
facility: Mater Misericordiae Uni Hospital; Oncology
city: Dublin
country: Ireland
facility: Beaumont Hospital; Cancer Clinical Trials Unit
city: Dublin
country: Ireland
facility: St Vincent'S Uni Hospital; Medical Oncology
city: Dublin
country: Ireland
facility: St. James Hospital; Oncology
city: Galway
country: Ireland
facility: Galway University Hospital; Clinical Trials Department
city: Limerick
country: Ireland
facility: University Hospital Limerick - Oncology
city: Haifa
country: Israel
facility: Rambam Medical Center; Oncology
city: Petach Tikva
country: Israel
facility: Rabin MC; Davidof Center - Oncology Institute
city: Ramat Gan
country: Israel
facility: Chaim Sheba Medical Center; Oncology Dept
city: Rehovot
country: Israel
facility: Kaplan Medical Center; Oncology Inst.
city: Tel Aviv
country: Israel
facility: Sourasky / Ichilov Hospital; Oncology Department
city: Catanzaro
country: Italy
facility: Campus Universitario S.Venuta; Centro Oncologico T.Campanella
state: Calabria
city: Avellino
country: Italy
facility: AORN'S.G.Moscati; Oncologia
state: Campania
city: Napoli
country: Italy
facility: IRCCS Istituto Nazionale Tumori Fondazione Pascale; Oncologia Medica A
state: Campania
city: Napoli
country: Italy
facility: Ist. Uni Federico Ii; Divisione Di Oncologia Medica - Dpt. Di Medicina Interna
state: Campania
city: Bologna
country: Italy
facility: Azienda Ospedaliero-Universitaria S.Orsola-Malpighi; Unità Operativa Oncologia Medica
state: Emilia-Romagna
city: Carpi
country: Italy
facility: Ospedale Ramazzini
state: Emilia-Romagna
city: Reggio Emilia
country: Italy
facility: Arcispedale Santa Maria Nuova; Oncologia
state: Emilia-Romagna
city: Aviano
country: Italy
facility: Irccs Centro Di Riferimento Oncologico (CRO); Dipartimento Di Oncologia Medica
state: Friuli-Venezia Giulia
city: Udine
country: Italy
facility: Divisione Onc Med dell'Azienda
state: Friuli-Venezia Giulia
city: Viterbo
country: Italy
facility: Ospedale Belcolle Di Viterbo; Oncologia
state: Lazio
city: Genova
country: Italy
facility: Ente Ospedaliero Ospedali Galliera; S.C. Oncologia Medica
state: Liguria
city: Genova
country: Italy
facility: Az. Osp. Uni Ria San Martino; Cliniche Uni Rie Convenzionate U.O. Oncologia Medical
state: Liguria
city: Genova
country: Italy
facility: IRCCS Istituto Nazionale Per La Ricerca Sul Cancro (IST); Oncologia Medica A
state: Liguria
city: Brescia
country: Italy
facility: ASST DEGLI SPEDALI CIVILI DI BRESCIA; Oncologia Medica
state: Lombardia
city: Lecco
country: Italy
facility: ASST DI LECCO; Oncologia Medica
state: Lombardia
city: Milano
country: Italy
facility: Irccs Istituto Europeo Di Oncologia (IEO); Ricerca Di Senologia Medica
state: Lombardia
city: Monza
country: Italy
facility: Policlinico di Monza; Istituto di Oncologia
state: Lombardia
city: Pavia
country: Italy
facility: IRCCS Fondazione Maugeri; Oncologia Medica I
state: Lombardia
city: Rozzano (MI)
country: Italy
facility: IRCCS Istituto Clinico Humanitas; Oncologia
state: Lombardia
city: Saronno
country: Italy
facility: Az. Osp. Di Busto P.O. Di Saronno; U.O. Di Oncologia Medica
state: Lombardia
city: Fano
country: Italy
facility: Ospedale S. Croce Di Fano; Servizio Oncologia
state: Marche
city: Candiolo
country: Italy
facility: Fondazione Del Piemonte Per L'oncologia Ircc Di Candiolo; Dipartimento Oncologico
state: Piemonte
city: Brindisi
country: Italy
facility: Ospedale Antonio Perrino; Oncologia Medica
state: Puglia
city: Prato
country: Italy
facility: Nuovo Ospedale di Prato S. Stefano - Azienda USL Toscana Centro
state: Toscana
city: Bolzano
country: Italy
facility: Ospedale Di Bolzano; Dept. Di Oncologia
state: Trentino-Alto Adige
city: Perugia
country: Italy
facility: Azienda Ospedaliera Di Perugia Ospedale s. Maria Della Misericordia; Oncologia Medica
state: Umbria
city: Terni
country: Italy
facility: Azienda Ospedaliera S. Maria - Terni; Oncologia
state: Umbria
city: Legnago
country: Italy
facility: Ospedale Mater Salutis; Dept of Oncology
state: Veneto
city: Aichi
country: Japan
facility: Aichi Cancer Center Hospital, Breast Oncology
city: Chiba
country: Japan
facility: Chiba Cancer Center; Breast Surgical Oncology
city: Chiba
country: Japan
facility: National Cancer Center Hospital East
city: Ehime
country: Japan
facility: Natl Hosp Org Shikoku; Cancer Ctr, Surgery
city: Fukuoka
country: Japan
facility: National Hospital Organization Kyushu Cancer Center;Breast Oncology
city: Gunma
country: Japan
facility: Gunma University Hospital; Department of Thoracic and Visceral Organ Surgery
city: Hiroshima
country: Japan
facility: Hiroshima City Hiroshima Citizens Hospital; Breast Surgery
city: Iwate
country: Japan
facility: Iwate Med Univ School of Med; Surgery
city: Kagoshima
country: Japan
facility: Sagara Hospital; Breast Surgery
city: Kanagawa
country: Japan
facility: St. Marianna University School of Medicine Hospital, Breast and Endocrine Surgery
city: Kanagawa
country: Japan
facility: Tokai University Hospital, Breast Surgery
city: Kumamoto
country: Japan
facility: Kumamoto City Hospital, Breast and Endocrine Surgery
city: Kumamoto
country: Japan
facility: Kumamoto Shinto General Hospital; Breast Cancer Center
city: Kyoto
country: Japan
facility: Kyoto University Hospital; Breast Surgery
city: Niigata
country: Japan
facility: Niigata Cancer Ctr Hospital; Breast Surgery
city: Osaka
country: Japan
facility: National Hospital Organization Osaka National Hospital; Breast Surgery
city: Osaka
country: Japan
facility: Osaka International Cancer Institute; Breast and Endocrine Surgery
city: Saitama
country: Japan
facility: Saitama Medical University International Medical Center; Breast Oncology
city: Saitama
country: Japan
facility: Saitama Cancer Center, Breast Oncology
city: Shizuoka
country: Japan
facility: Shizuoka Cancer Center; Breast Surgery
city: Shizuoka
country: Japan
facility: Shizuoka General Hospital; Breast Surgery
city: Tochigi
country: Japan
facility: Jichi Medical School ; Surgery
city: Tokyo
country: Japan
facility: National Cancer Center Hospital; Medical Oncology
city: Tokyo
country: Japan
facility: Tokyo Metropolitan; Komagome Hospital, Surgery
city: Tokyo
country: Japan
facility: The Cancer Inst. Hosp. of JFCR; Breast Oncology Center
city: Tokyo
country: Japan
facility: Tokyo Medical Uni. Hospital; Breast Oncology
city: Seongnam-si
country: Korea, Republic of
facility: Seoul National University Bundang Hospital
city: Seoul
country: Korea, Republic of
facility: Seoul National Uni Hospital; Dept. of Internal Medicine/Hematology/Oncology
city: Seoul
country: Korea, Republic of
facility: Yonsei University Severance Hospital; Medical Oncology
city: Seoul
country: Korea, Republic of
facility: Kyunghee University Hospital; Endocrinology
city: Seoul
country: Korea, Republic of
facility: Samsung Medical Centre; Division of Hematology/Oncology
city: Seoul
country: Korea, Republic of
facility: Korea University Anam Hospital; Oncology Haemotology
city: Campehe
country: Mexico
facility: Centro Estatal de Oncología de Campeche
state: Campeche
city: León
country: Mexico
facility: Fundacion Rodolfo Padilla Padilla A.C.
state: Guanajuato
city: Guadalajara
country: Mexico
facility: Núcleo de Especialidades Oncológicas
state: Jalisco
city: Mexico City
country: Mexico
facility: Hospital Angeles Metropolitano; Room 220
state: Mexico CITY (federal District)
city: Mexico DF
country: Mexico
facility: Hospital General de México; Unidad de Oncologia
state: Mexico CITY (federal District)
city: Monterrey
country: Mexico
facility: Centro Universitario Contra El Cancer
state: Nuevo LEON
city: Montrrey
country: Mexico
facility: Centro de Diagnóstico y Tratamiento Integral de Mama, Hospital San José Tec de Monterrey
state: Nuevo LEON
city: Oaxaca de Juárez
country: Mexico
facility: Oaxaca Site Management Organization
state: Oaxaca
city: Queretaro, Queretaro
country: Mexico
facility: Cancerologia de Queretaro; Oncologia
state: Queretaro
city: Aguascalientes
country: Mexico
facility: Médicos Especialistas en Cáncer SC
city: Durango
country: Mexico
facility: Centro Estatal De Cancerologia De Durango; Oncology
city: San Luis Potosi
country: Mexico
facility: Centro Regional de Enfermedades Oncológicas, S.A.
city: Alkmaar
country: Netherlands
facility: Medisch Centrum Alkmaar
city: Breda
country: Netherlands
facility: Amphia ziekenhuis, locatie langendijk
city: Delft
country: Netherlands
facility: Reinier de Graaf Gasthuis
city: Maastricht
country: Netherlands
facility: Academish Ziekenhuis Maastricht (Azm); Inwendige Geneeskunde
city: Zwolle
country: Netherlands
facility: Isala Klinieken
city: Hamilton
country: New Zealand
facility: Waikato Hospital; Dept of Medical Oncology
city: Palmerston North
country: New Zealand
facility: Palmerston North Hospital; Regional Cancer Treatment Service
city: Panama
country: Panama
facility: The Panama Clinic
city: Panama
country: Panama
facility: Centro Oncologico America
city: Lima
country: Peru
facility: Instituto Nacional de Enfermedades Neoplasicas
city: Lima
country: Peru
facility: Clinica Anglo Americana - Centro de Investigacion Oncologia CAA
city: San Isidro
country: Peru
facility: Clinica El Golf
city: Trujillo
country: Peru
facility: Clinica Peruana Americana
city: Manila
country: Philippines
facility: University Of Santo Tomas; Oncology; Benavides Cancer Institute
city: Pasig City
country: Philippines
facility: Rizal Medical Center
city: Quezon City
country: Philippines
facility: Veterans Memorial Medical Ctr; Cancer Research Centre
city: Bialystok
country: Poland
facility: Bialostockie Ctr Onkologii; Oddzial Chemioterapii Dziennej
city: Bydgoszcz
country: Poland
facility: Centrum Onkologii;Im. Franciszka Lukaszczyka;Onkologii
city: Gdansk
country: Poland
facility: Uniwersyteckie Centrum Kliniczne, Klinika Onkologii i Radioterapii
city: Opole
country: Poland
facility: Opolskie Centrum Onkologii;Oddzial Onkologii Klinicznej
city: Warszawa
country: Poland
facility: Narodowy Inst.Onkologii im.Sklodowskiej-Curie Panstw.Inst.Bad; Klinika Nowtw.Piersi i Chir.Rekonstr
city: Wieliszew
country: Poland
facility: NZOZ Mazowiecki Szpital Onkologiczny Uczelni Warszawskiej im. M. Sk?odowskiej-Curie
city: Bucharest
country: Romania
facility: Emergency University Bucharest Hospital; Oncology Department
city: Cluj Napoca
country: Romania
facility: Prof. Dr. I. Chiricuta Institute of Oncology
city: Cluj-Napoca
country: Romania
facility: Oncology Inst. Cluj-Napoca; Cancer Dept
city: Iasi
country: Romania
facility: Euroclinic Center of Oncology SRL
city: Moscow
country: Russian Federation
facility: S.I. Russian Oncological Research Center n.a. N.N. Blokhin
state: Moskovskaja Oblast
city: Pyatigorsk
country: Russian Federation
facility: State Budget Institution of Healthcare of Stavropol region Pyatigorsk Oncology Dispensary
state: Stavropol
city: Kazan
country: Russian Federation
facility: Clinical Oncology Dispensary of Ministry of Health of Tatarstan
state: Tatarstan
city: Samara
country: Russian Federation
facility: SBI of Healthcare Samara Regional Clinical Oncology Dispensary
city: Stavropol
country: Russian Federation
facility: SBI of Healthcare of Stavropol region Stavropol Regional Clinical Oncology Dispensary
city: Tula
country: Russian Federation
facility: Tula Regional Oncology Dispensary
city: Ljubljana
country: Slovenia
facility: Institute of Oncology Ljubljana
city: Bloemfontein
country: South Africa
facility: National Hospital; Oncotherapy Dept
city: Johannesburg
country: South Africa
facility: Wits Donald Gordon Clinical Trial Centre; Medical Oncology
city: Pretoria
country: South Africa
facility: Steve Biko Academic Hospital; Oncology
city: Elche
country: Spain
facility: Hospital General Universitario de Elche; Servicio de Oncologia
state: Alicante
city: Badalona
country: Spain
facility: Hospital Universitari Germans Trias i Pujol; Servicio de Oncologia
state: Barcelona
city: Sabadell
country: Spain
facility: Corporacio Sanitaria Parc Tauli; Servicio de Oncologia
state: Barcelona
city: Sant Andreu de La Barca
country: Spain
facility: Hospital Univ Vall d'Hebron; Servicio de Oncologia
state: Barcelona
city: Santander
country: Spain
facility: Hospital Universitario Marques de Valdecilla; Servicio de Oncologia
state: Cantabria
city: Castellon de La Plana
country: Spain
facility: Hospital Provincial de Castellon; Servicio de Oncologia
state: Castellon
city: Córdoba
country: Spain
facility: Hospital Universitario Reina Sofia; Servicio de Oncologia
state: Cordoba
city: San Sebastian
country: Spain
facility: IInstituto Oncologico de San Sebastian, Oncologikoa; Servicio de Oncologia
state: Guipuzcoa
city: San Sebastian
country: Spain
facility: Hospital de Donostia; Servicio de Oncologia Medica
state: Guipuzcoa
city: Palma De Mallorca
country: Spain
facility: Hospital Universitario Son Espases
state: Islas Baleares
city: Palma de Mallorca
country: Spain
facility: Hospital Son Llatzer; Servicio de Oncologia
state: Islas Baleares
city: Santiago de Compostela
country: Spain
facility: Complejo Hospitalario Universitario de Santiago (CHUS) ; Servicio de Oncologia
state: LA Coruña
city: La Laguna
country: Spain
facility: Hospital Universitario de Canarias;servicio de Oncologia
state: Tenerife
city: Barcelona
country: Spain
facility: Hospital del Mar; Servicio de Oncologia
city: Barcelona
country: Spain
facility: Hospital Clínic i Provincial; Servicio de Hematología y Oncología
city: Barcelona
country: Spain
facility: Hospital de la Santa Creu i Sant Pau; Servicio de Oncologia
city: Barcelona
country: Spain
facility: Hospital Duran i Reynals; Oncologia
city: Huelva
country: Spain
facility: Hospital Juan Ramon Jimenez;Servicio de Oncologia
city: Jaen
country: Spain
facility: Complejo Hospitalario de Jaen-Hospital Universitario Medico Quirurgico; Servicio de Oncologia
city: La Coruña
country: Spain
facility: Complejo Hospitalario Universitario A Coruña (CHUAC, Materno Infantil), Oncología
city: La Coruña
country: Spain
facility: Centro Oncológico Gallego José Antonio Quiroga y Piñeiro, Servicio de Oncologia
city: Lerida
country: Spain
facility: Hospital Universitari Arnau de Vilanova de Lleida; Servicio de Oncologia
city: Madrid
country: Spain
facility: Hospital General Universitario Gregorio Marañon; Servicio de Oncologia
city: Madrid
country: Spain
facility: Centro Oncologico MD Anderson Internacional; Servicio de Oncologia
city: Madrid
country: Spain
facility: Hospital Ramon y Cajal; Servicio de Oncologia
city: Madrid
country: Spain
facility: Hospital Universitario Clínico San Carlos; Servicio de Oncologia
city: Madrid
country: Spain
facility: Hospital Universitario 12 de Octubre; Servicio de Oncologia
city: Madrid
country: Spain
facility: Centro Integral Oncologico Clara Campal (CIOCC); Dirección Médica
city: Malaga
country: Spain
facility: Hospital Clinico Universitario Virgen de la Victoria; Servicio de Oncologia
city: Murcia
country: Spain
facility: Hospital General Universitario J.M Morales Meseguer; Servicio de Oncologia
city: Salamanca
country: Spain
facility: Hospital Clinico Universitario de Salamanca; Servicio de Oncologia
city: Sevilla
country: Spain
facility: Hospital Universitario Virgen Macarena; Servicio de Oncologia
city: Sevilla
country: Spain
facility: Hospital Universitario Virgen del Rocio; Servicio de Oncologia
city: Sevilla
country: Spain
facility: Hospital Univ. Nuestra Señora de Valme; Servicio de Oncologia
city: Toledo
country: Spain
facility: Complejo Hospitalario de Toledo- H. Virgen de la Salud; Servicio de Oncologia
city: Valencia
country: Spain
facility: Instituto Valenciano Oncologia; Oncologia Medica
city: Valencia
country: Spain
facility: Hospital Clinico Universitario de Valencia; Servicio de Onco-hematologia
city: Valencia
country: Spain
facility: Hospital Arnau de Vilanova (Valencia) Servicio de Oncologia
city: Valencia
country: Spain
facility: Hospital Universitario la Fe; Servicio de Oncologia
city: Zaragoza
country: Spain
facility: Hospital Universitario Miguel Servet; Servicio Oncologia
city: Gothenburg
country: Sweden
facility: Sahlgrenska Universitetssjukhuset; Onkology
city: Linköping
country: Sweden
facility: Uni Hospital Linkoeping; Dept. of Oncology
city: Stockholm
country: Sweden
facility: Karolinska University Hospital; Department of General Oncology
city: Umea
country: Sweden
facility: Norrlands Universitetssjukhus, Umeå, Cancercentrum; Dept of Oncology
city: Uppsala
country: Sweden
facility: Akademiska sjukhuset, Onkologkliniken
city: Basel
country: Switzerland
facility: Universitaetsspital Basel; Onkologie
city: Genève 14
country: Switzerland
facility: Hôpitaux Universit. de Genève Gynécologique - Oncologie; Gynécologie
city: Luzern
country: Switzerland
facility: Luzerner Kantonsspital; Medizinische Onkologie
city: St. Gallen
country: Switzerland
facility: Kantonsspital St. Gallen; Onkologie/Hämatologie
city: Zürich
country: Switzerland
facility: Brust-Zentrum Zürich AG Seefeldstrasse 214 Zürich
city: Changhua
country: Taiwan
facility: Changhua Christian Hospital; Dept of Surgery
city: Kaohsiung
country: Taiwan
facility: Kaohsiung Medical Uni Chung-Ho Hospital; Dept of Surgery
city: Taichung
country: Taiwan
facility: Taichung Veterans General Hospital; Dept of Surgery
city: Tainan
country: Taiwan
facility: National Cheng Kung Uni Hospital; Surgery
city: Taipei
country: Taiwan
facility: VETERANS GENERAL HOSPITAL; Department of General Surgery
city: Taipei
country: Taiwan
facility: National Taiwan Uni Hospital; General Surgery
city: Taipei
country: Taiwan
facility: Tri-Service General Hospital, Division of General Surgery
city: Chiang Rai
country: Thailand
facility: Chiang Rai Prachanukraw Hospital; Department of Pediatrics, Faculty of Medicine
city: Lopburi
country: Thailand
facility: Lopburi Cancer Hospital; Chemotherpy Unit; Chemotherapy
city: Phitsanuok
country: Thailand
facility: Buddhachinaraj Phitsanulok Hospital; Chemotherapy Unit ; Department of Medicine
city: Songkla
country: Thailand
facility: Songklanagarind Hospital; Department of Surgery
city: Surat Thani
country: Thailand
facility: Surat Thani Hospital
city: Cherkassy
country: Ukraine
facility: Cherkassy Regional Oncological Hospital
city: Dnipropetrovsk
country: Ukraine
facility: State Medical Academy; Oncology
city: Ivano-Frankivsk
country: Ukraine
facility: Ivano-Frankivsk Regional Oncology Center
city: Kiev
country: Ukraine
facility: Kyiv City Clinical Oncological Center, Day Hospital Department for Oncological patients
city: Lutsk
country: Ukraine
facility: Volyn Regional Oncology Dispensary
city: Lvov
country: Ukraine
facility: Lvov State Regional Oncology Medical & Diagnostic Center
city: Ternopil
country: Ukraine
facility: Ternopil State Medical Academy
city: Berkshire
country: United Kingdom
facility: Royal Berkshire Hospital; Berkshire Cancer Centre
city: Cardiff
country: United Kingdom
facility: Velindre Cancer Centre; Oncology Dept
city: Cheltenham
country: United Kingdom
facility: Cheltenham General Hospital; Gloucestershire Oncology Centre
city: Colchester, Essex
country: United Kingdom
facility: Colchester General Hospital
city: Cornwall
country: United Kingdom
facility: Royal Cornwall Hospital; Dept of Clinical Oncology
city: Coventry
country: United Kingdom
facility: University Hospital coventry; Oncology Department
city: Edinburgh
country: United Kingdom
facility: Western General Hospital; Edinburgh Breast Unit
city: Exeter
country: United Kingdom
facility: Royal Devon & Exeter Hospital; Oncology Centre
city: Ipswich
country: United Kingdom
facility: Ipswich Hospital; Oncology Pharmacy
city: Leeds
country: United Kingdom
facility: St James Uni Hospital; Icrf Cancer Medicine Research Unit
city: London
country: United Kingdom
facility: St. Bartholomew'S Hospital; Dept of Medical Oncology
city: London
country: United Kingdom
facility: UCL Hospital NHS Trust
city: London
country: United Kingdom
facility: Royal Marsden Hospital; Dept of Med-Onc
city: Manchester
country: United Kingdom
facility: Christie Hospital; Breast Cancer Research Office
city: Northwood
country: United Kingdom
facility: Mount Vernon Hospital; Centre For Cancer Treatment
city: Nottingham
country: United Kingdom
facility: Nottingham City Hospital; Oncology
city: Oxford
country: United Kingdom
facility: Churchill Hospital; Oxford Cancer and Haematology Centre
city: Peterborough
country: United Kingdom
facility: Peterborough City Hospital, Edith Cavell Campus; Oncology Department
city: Portsmouth
country: United Kingdom
facility: Queen Alexandra Hospital; Haematology and Oncology Centre
city: Preston
country: United Kingdom
facility: Royal Preston Hosp; Rosemere Cancer Ctr
city: Sheffield
country: United Kingdom
facility: Weston Park Hospital; Cancer Clinical Trials Centre
city: Stoke-on-Trent
country: United Kingdom
facility: Uni Hospital of North Staffordshire; Staffordshire Oncology Centre
city: Sutton
country: United Kingdom
facility: Royal Marsden Hosp NHS Fnd; Medicine - Breast Unit
city: Wirral
country: United Kingdom
facility: The Clatterbridge Cancer Ctr For Oncolgy
city: Wolverhampton
country: United Kingdom
facility: New Cross Hospital; Deansley Centre
Study officials:
affiliation: Hoffmann-La Roche
name: Clinical Trials
role: STUDY_DIRECTOR
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