louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT04262245: Comparison of Different Irrigation Activation Techniques on Postoperative Pain After Endodontic Treatment
Official title: Comparison of Different Irrigation Activation Techniques on Postoperative Pain After Endodontic Treatment
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Postoperative Pain
Lead sponsor: Bulent Ecevit University
Sponsor class: OTHER
First posted: 2020-02-10
Enrollment: 100
Sex: ALL
Minimum age (years): 18
Maximum age (years): 65
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: TREATMENT

Brief summary: The aim of this study is to evaluate the effect of different irrigation activation methods on postoperative pain using visual analog scale (VAS) using Xp-endo Finisher, EndoActivator and Passive ultrasonic irrigation activation techniques with traditional irrigation method.

In this study, Traditional Irrigation (GI), Xp-endo Finisher (XPF), Passive Ultrasonic Irrigation (PUI), EndoActivator (EA) techniques will be used for irrigation activation. Twenty-five maxillary or mandibular single root and canal-shaped nonvital teeth will used in each group. Root canals will be prepared with TF-Adaptive system. Four different activation techniques will be applied during final irrigation. The canal treatments will be completed in one stage and postoperative pain analysis will be taken with VAS (Visual Analog Scale) scale after 12-24-48 hours. Statistical analysis will be performed with Mann Whitney-U test.

Detailed description: Vaious irrigation activation techniques have been used endodontic practice. These techniques are used to improve the activity of solutions. The selected techniques in this study are accepted as efficient methods for activation. However, postoperative pan is an important issue for clinicians. Thus, Traditional Irrigation (GI), Xp-endo Finisher (XPF), Passive Ultrasonic Irrigation (PUI), EndoActivator (EA) techniques will be used for irrigation activation. All techniques remove hard and soft tissue remnants successfully. The clinician expect to eliminate the postoperative pain. Therefore, a possible increase in pain due to activation technique may limit the use of these methods. The pain scores will be measured using the scale and statistically analyzed.

Eligibility criteria: Inclusion Criteria:

* nonvital tooth
* single rooted tooth

Exclusion Criteria:

* tooth not requiring root canal treatment
* patients under 18 years old
* vital tooth
* tooth having more than 1 canal

Primary outcomes:
measure: Incidence of postoperative after endodontic treatment
timeFrame: 0-48 hours
Secondary outcomes:
Other outcomes:
Locations:
city: Zonguldak
country: Turkey
facility: Bülent Ecevit University, Faculty of Dentistry
Study officials:
References:
Clinical trial NCT00743145: Effects of Low-dose Naltrexone in Combination With a Range of Smoked Marijuana
Official title: Effects of Low-dose Naltrexone in Combination With a Range of Smoked Marijuana
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE2
Conditions: Marijuana Smoking
Keywords: naltrexone
smoked marijuana
marijuana use
Lead sponsor: New York State Psychiatric Institute
Sponsor class: OTHER
Collaborators: name: Research Foundation for Mental Hygiene, Inc.
name: National Institute on Drug Abuse (NIDA)
First posted: 2008-08-28
Enrollment: 23
Sex: ALL
Minimum age (years): 21
Maximum age (years): 45
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: CROSSOVER
Primary purpose: BASIC_SCIENCE

Brief summary: In heavy marijuana smokers, opioid receptor blockade increases the subjective and cardiovascular effects of marijuana. The current study was designed to clarify opioid-cannabinoid interactions by assessing how naltrexone shifts the dose-response function for marijuana-elicited effects in heavy marijuana smokers. For this within-subject, double-blind study, a marijuana smoking procedure was designed to characterize a dose-response relationship for marijuana's subjective and cardiovascular effects under blinded conditions.


Eligibility criteria: Inclusion Criteria:

* Current marijuana use
* Able to perform study procedures
* Women practicing an effective form of birth control

Exclusion Criteria:

* Current repeated illicit drug use (other than marijuana)
* Presence of significant medical illness (e.g., diabetes, cardiovascular disease,hypertension, hepatitis, clinically significant laboratory abnormalities, LFTs \> 3x upper limit of normal, blood pressure \> 140/90

Primary outcomes:
measure: Subjective Marijuana Effects
timeFrame: 180 minutes after marijuana administration, during each of 8 outpatient sessions over the course of 3-6 weeks.
Secondary outcomes:
Other outcomes:
Locations:
city: New York
country: United States
facility: New York State Psychiatric Institute
state: New York
Study officials:
affiliation: New York State Psychiatric Institute
name: Margaret Haney, Ph.D.
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT06992245: Characterization of Placental Diffusion
Official title: Characterization of Placental Diffusion in Women With Diabetes Using DW-MRI
Study type: INTERVENTIONAL
Overall status: RECRUITING
Phase: NA
Conditions: Pregnancy in Diabetic
Placenta Diseases
Lead sponsor: Hillel Yaffe Medical Center
Sponsor class: OTHER_GOV
First posted: 2025-05-28
Enrollment: 40
Sex: FEMALE
Minimum age (years): 18
Maximum age (years): 50
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: NON_RANDOMIZED
Intervention model: PARALLEL
Intervention model description: The 2 arms will include 3th trimester pregnant women. Group 1- diabetic pregnant women Group 2- low risk pregnant women
Primary purpose: DIAGNOSTIC

Brief summary: DW-MRI Allows a quantitative comparison of diffusion as an expression of tissue hypoxia. The investigators aim is to compare changes in placental diffusion in pregnant women with uncontrolled diabetes compared to healthy pregnant women using DW-MRI.

The investigators hypothesize that placentas of diabetic mothers will show lower diffusion / perfusion compared to placentas of healthy women.

Detailed description: In highly uncontrolled diabetes there is an increased risk of intrauterine fetal death. The mechanism of fetal death is unknown and unpredictable. One of the theories points to hypoxia as a precursor to the death of the fetus in the womb. If the researchers succeed in predicting changes in the placenta with the help of MRI, it may be possible to understand the mechanism of fetal damage as well as in the future to develop a protocol for predicting pregnancies prone to fetal death in the womb.

Eligibility criteria: Inclusion Criteria:

* Women with PGAM (Pre-gestational diabetes) diagnosed before 20 weeks of pregnancy
* Women with GDMA (Gestational diabetes) diagnosed by OGTT after 20 weeks of pregnancy

Exclusion Criteria:

* pregnant women with placental hypoxia disease related in the past
* pregnant women with placental hypoxia disease related in the present
* non-singleton pregnancy
* women in active labor or rupture of membrane
* smoking women
* suspicion of placenta accreta

Primary outcomes:
measure: IVIM-DWI-based placental functional assessment from research DWI data.
timeFrame: Two years
measure: IVIM-DWI-based placental functional assessment from research DWI data.
timeFrame: Two years
measure: IVIM-DWI-based placental functional assessment from research DWI data.
timeFrame: Two years
Secondary outcomes:
measure: Significance of the groups differences for each parameter
timeFrame: Two years
Other outcomes:
Locations:
city: Hadera
country: Israel
facility: Hille Yaffe Medical Center
Study officials:
affiliation: Hillel Yaffe Medical Center
name: Rinat Gabbay-Benziv, Prof
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT02050945: The Effects of Physical Exercise Training in Patients With Chronic Obstructive Pulmonary Disease
Official title: The Effects of Physical Exercise Training in Patients With Chronic Obstructive Pulmonary Disease
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: COPD
Exercise
Resistance Training
Lead sponsor: Rigshospitalet, Denmark
Sponsor class: OTHER
Collaborators: name: Copenhagen University Hospital, Hvidovre
First posted: 2014-01-31
Enrollment: 30
Sex: ALL
Minimum age (years): 40
Maximum age (years): 80
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: BASIC_SCIENCE

Brief summary: The purpose of the present project is to investigate the physiological effects of two different types of exercise training in COPD patients. The patients will be examined before, during and after 8 weeks of training to evaluate the effect of different types of skeletal muscle stimulation on health related quality of life, 6 min walking distance, flow mediated dilation, and histological properties of skeletal muscle cells, regarding oxidative capacity, fiber type, purinergic receptor amounts and measures of systemic inflammation. The study will test the hypothesis that:

Resistance training is superior to endurance training in patients with COPD


Eligibility criteria: Inclusion Criteria:

* FEV1/FVC fixed ratio \<0.70, FEV1: \<60% of predicted and MRC \> or equal to 3
* Arterial oxygen saturation at rest\> 90%, BMI \>18, LVEF\> 45.
* Age: 40 - 80 years

The medical treatment will be continued unchanged during the study and additional prednisolone and /or antibiotic treatment will be prescribed in case of acute exacerbation.

Exclusion Criteria:

* Unstable ischemic heart disease, severe heart valve failure, pulmonary emboli, severe heart failure, severe infections, musculoskeletal disorders, malignant disease, contraindicated medicine as MAO inhibitors and anticoagulants.

Primary outcomes:
measure: Skeletal muscle function
timeFrame: At baseline and after 8 weeks of traning
Secondary outcomes:
measure: Flow mediated dilation
timeFrame: Change from baseline at 8 weeks
measure: Body composition
timeFrame: Change from baseline at 8 weeks
measure: 6 min walking test
timeFrame: Change from baseline at 8 weeks
measure: Health Related Quality of Life - COPD assessment test (CAT)
timeFrame: Change from baseline at 8 weeks
Other outcomes:
Locations:
city: Copenhagen
country: Denmark
facility: Centre of Physical Activity Resarch
state: Capital Region
city: Copenhagen
country: Denmark
facility: Centre of Physical Activity Research
state: Capital Region
Study officials:
affiliation: Centre of Inflammation and Metabolism, University of Copenhagen, Rigshospitalet
name: Stefan Mortensen, DMSc
role: STUDY_CHAIR
References:
Clinical trial NCT02023645: The Effects of a Carotenoid Intervention on Cognitive Function
Official title: The Effects of a Lutein + Zeaxanthin Intervention on Cognitive Function and Neural Efficiency
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Mild Cognitive Impairment
Keywords: lutein
cognition
neural efficiency
aging
Lead sponsor: University of Georgia
Sponsor class: OTHER
Collaborators: name: Abbott Nutrition
name: DSM Nutritional Products, Inc.
First posted: 2013-12-30
Enrollment: 120
Sex: ALL
Minimum age (years): 18
Maximum age (years): 95
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: BASIC_SCIENCE

Brief summary: Past research suggests that retinal lutein levels are related to cognitive function as measured via behavioral tests. The goal of the present study is to investigate the relationship between lutein and cognitive function in a wider variety of the population (young, healthy adults and older adults), using a wider variety of methods (behavioral testing and neuroimaging).

Detailed description: Past research suggests that retinal lutein levels are related to cognitive function as measured via behavioral tests. The goal of the present study is to investigate the relationship between lutein and cognitive function in a wider variety of the population (young, healthy adults and older adults), using a wider variety of methods (behavioral testing and neuroimaging).

Eligibility criteria: Inclusion Criteria:

* visual acuity correctable to 20:40 or better, Snellen notation
* able to swallow a dietary supplement
* free of dementia, characterized by a score of less than 1.5 on the Clinical Dementia Rating Scale

Exclusion Criteria:

* GI conditions that interfere with lipid absorption
* presence of or past diagnosis of age-related macular degeneration
* visual acuity poorer than 20:40, Snellen notation
* has taken lutein, omega-3 fatty acid or fish oil supplements within the last 6 months
* presence of dementia, characterized by a score of 1.5 or greater on the Clinical Dementia Rating Scale

Primary outcomes:
measure: macular pigment optical density
timeFrame: 12 months
Secondary outcomes:
measure: serum carotenoid levels
timeFrame: 12 months
measure: reaction time
timeFrame: 12-months
measure: executive function
timeFrame: 12-months
measure: short-term memory
timeFrame: 12-months
measure: visual attention
timeFrame: 12-months
Other outcomes:
Locations:
city: Athens
country: United States
facility: The University of Georgia
state: Georgia
Study officials:
affiliation: The University of Georgia
name: Billy R Hammond, Ph.D.
role: PRINCIPAL_INVESTIGATOR
References:
citation: Mewborn CM, Lindbergh CA, Hammond BR, Renzi-Hammond LM, Miller LS. The Effects of Lutein and Zeaxanthin Supplementation on Brain Morphology in Older Adults: A Randomized, Controlled Trial. J Aging Res. 2019 Dec 1;2019:3709402. doi: 10.1155/2019/3709402. eCollection 2019.
Clinical trial NCT01554345: Effect of Vitamin E+Selenium on Kidney Function in Controlled Hypotension
Official title: Assessment of Preventive Effect of Vitamin E +Selenium on Acute Kidney Injury Through NGAL in Patients Undergoing Controlled Hypotension During Neurosurgery Operations
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: PHASE2
Conditions: Acute Kidney Injury
Lead sponsor: Tehran University of Medical Sciences
Sponsor class: OTHER
First posted: 2012-03-14
Enrollment: 60
Sex: ALL
Minimum age (years): 18
Maximum age (years): 75
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: PREVENTION

Brief summary: The purpose of this study is to determine whether Kidney injury happens in controlled hypotension during brain operations by using Neutrophil Gelatinase Associated Lipocalin ELISA Kit and if so, does VitaminE+Selenium prevent it

Detailed description: NGAL(Neutrophil Gelatinase Associated Lipocalin) is a 25KD protein which bounds with Gelatinase in Neutrophil granules.It is also expressed in epithelial cells of kidney tubules.NGAL increases in ischemic and toxic injuries of kidney. During controlled hypotension in brain operations injury to the kidneys might occur . This study is designed to assess this possibility and evaluate the effect of VitaminE+Selenium on prevention of this problem

Eligibility criteria: Inclusion Criteria:

* All patients who are candidate for brain surgery under controlled hypotension

Exclusion Criteria:

* Positive history of renal disease
* Positive history of diabetes mellitus, CHF, HTN, Breast cancer, fever, leukocytosis

Primary outcomes:
measure: increased amount of urinary or serum NGAL after controlled hypotension
timeFrame: from 2 hours to 24 hours after controlled hypotension
Secondary outcomes:
Other outcomes:
Locations:
city: Tehran
country: Iran, Islamic Republic of
facility: Tehran university of medical sciences, Imam Khomeini Hospital, neurosurgery operation room and ward
Study officials:
References:
Clinical trial NCT00901745: Interaction of Apelin and Angiotensin in the Human Forearm Circulation
Official title: Investigating the Interaction of Apelin and Angiotensin II Peripheral Resistance Vessels in Vivo in Man
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Heart Disease
Vasodilation
Keywords: Renin angiotensin system
Apelin
Vasodilatation
Heart disease
Vascular biology
Lead sponsor: University of Edinburgh
Sponsor class: OTHER
First posted: 2009-05-14
Enrollment: 12
Sex: ALL
Minimum age (years): 18
Maximum age (years): 85
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: CROSSOVER
Primary purpose: BASIC_SCIENCE

Brief summary: The apelin-APJ system is a relatively new discovery. It has generated interest in part due to it's apparent ability to counteract the renin-angiotensin system, which is frequently overactive in many cardiovascular disease.

Apelin has the ability to cause blood vessels to relax, increasing their diameter and hence blood flow down the blood vessel. The researchers wish to investigate the hypothesis that an infusion of apelin will reduce the effects of angiotensin II, which is know to reduce the diameter of blood vessels.


Eligibility criteria: Inclusion Criteria:

* \> 18 years old
* Healthy volunteers

Exclusion Criteria:

* Lack of informed consent
* Age \< 18 years,
* Current involvement in other research studies,
* Systolic blood pressure \>190 mmHg or \<100 mmHg
* Malignant arrhythmias
* Renal or hepatic failure
* Haemodynamically significant aortic stenosis
* Severe or significant co morbidity
* Women of childbearing potential.
* Any regular medication

  * Previous history of any cardiovascular disease

Primary outcomes:
measure: Change in angiotensin II mediated vasoconstriction
timeFrame: 12 months
Secondary outcomes:
measure: Changes in relevant neurohumoral hormones in response to apelin infusion
timeFrame: 12 months
Other outcomes:
Locations:
city: Edinburgh
country: United Kingdom
facility: Clincial Research Facility, Royal Infirmary of Edinburgh, 51 Little France Cresc
Study officials:
affiliation: University of Edinburgh
name: Gareth D Barnes, MBChB
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT05120245: Fertility Preservation in Transgender Persons: a Retrospective Look
Official title: Fertility Preservation in Transgender Persons: a Retrospective Look At the Decision and a Survey of the Desire for Children.
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Fertility Preservation in Transgender Persons
Lead sponsor: University Hospital, Ghent
Sponsor class: OTHER
First posted: 2021-11-15
Enrollment: 20
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: COHORT
Time perspective: RETROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: transgender personen

Brief summary: Patients in this study will be asked how they feel about the decision to freeze gametes, using a validated questionnaire. In addition, a number of questions with free text fields will be included in the questionnaire to write down any reasons for their satisfaction or regret. In a second part, the intention to use the frozen material will be assessed. We focus on techniques with real perspectives (e.g. cryopreservation of oocytes and sperm cells) and not on techniques that are more experimental for later use (cryopreservation of ovarian and testicular tissue).


Eligibility criteria: Inclusion Criteria:

* Dutch speaking
* Sperm or oocyte preservation between june 2015 and june 2020. Survey in 2021

Exclusion Criteria:

* Ovarian and testicular tissue cryopreservation

Primary outcomes:
measure: Transgender people's retrospective view of the decision
timeFrame: fertility preservation between june 2015 and june 2020 (5 years). Survey in 2021 (up to 7 years after preservation)
measure: Satisfaction/ regret about the decision
timeFrame: fertility preservation between june 2015 and june 2020 (5 years). Survey in 2021 (up to 7 years after preservation)
measure: Intention
timeFrame: fertility preservation between june 2015 and june 2020 (5 years). Survey in 2021 (up to 7 years after preservation)
Secondary outcomes:
Other outcomes:
Locations:
city: Ghent
country: Belgium
facility: Ghent University hospital
Study officials:
affiliation: University Hospital, Ghent
name: Stoop
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT06920745: TriClip CED RWE Study
Official title: TRIClip CoverAge With Evidence Development (CED) Real-World Evidence (RWE) Study (TRICARE)
Study type: OBSERVATIONAL
Overall status: NOT_YET_RECRUITING
Conditions: Tricuspid Regurgitation
Keywords: TriClip
Coverage with Evidence Development
Tricuspid Transcatheter Edge-to-Edge Repair
Lead sponsor: Abbott Medical Devices
Sponsor class: INDUSTRY
First posted: 2025-04-10
Enrollment: 2200
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Real-world patients with symptomatic, severe or greater tricuspid regurgitation in the United States

Brief summary: This Coverage with Evidence Development (CED) study evaluates the long-term health outcomes of patients with symptomatic, severe or greater Tricuspid Regurgitation who received a Tricuspid Transcatheter Edge-to-Edge Repair (T-TEER) procedure using the TriClip system.

Detailed description: The TRICARE will assess 2-year effectiveness in patients with symptomatic, severe or greater TR who undergo Tricuspid Transcatheter Edge-to-Edge Repair (T-TEER) with the TriClip system, as compared to a contemporaneous control of patients without T-TEER.

Eligibility criteria: Inclusion Criteria:

* Patients ≥ 18 years of age at time of implant
* Patients with symptomatic, severe or greater Tricuspid Regurgitation who have received the TriClip system (treatment group) or have not undergone T-TEER (control group)

Exclusion Criteria:

* Patients with less than severe Tricuspid Regurgitation
* Patients with a prior history of surgical or transcatheter tricuspid valve replacement
* Patients with a surgical or transcatheter aortic or mitral valve intervention prior to index

Primary outcomes:
measure: Composite of heart failure hospitalization or all-cause mortality
timeFrame: 2 years
Secondary outcomes:
measure: Tricuspid valve re-intervention
timeFrame: 2 years
Other outcomes:
Locations:
city: Santa Clara
country: United States
facility: Abbott
state: California
Study officials:
References: