Clinical trial NCT06095609: The Implementation of Early Mobilization and Chest Physiotherapy on Weaning Rate of Prolong Weaning Patients.
Official title: The Implementation of Early Mobilization and Chest Physiotherapy on Weaning Rate of Prolong Weaning Patients. A Retrospective Study
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Prolonged Weaning, Early Mobilization, Chest Physiotherapy
Lead sponsor: Taoyuan General Hospital
Sponsor class: OTHER_GOV
First posted: 2023-10-23
Enrollment: 202
Sex: ALL
Minimum age (years): 20
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NON_RANDOMIZED
Intervention model: PARALLEL
Intervention model description: The study retrospectively reviewed the medical record from the medical team. Patients before 2019/01/01 who didn't receive physiotherapy are regarded as control group. Patients after 2019/01/01 are assigned to the experiment group.
Primary purpose: TREATMENT

Brief summary: Weaning from mechanical ventilator is essential to liberate patients to normal life. Prolong weaning is defined as failure of 3 times spontaneous breath trial (SBT) and requiring more than 7 days weaning from mechanical ventilation after first SBT. higher unsuccessful rate of extubation and higher mortality rate. Possible reasons to cause prolong weaning could be attributed to intensive care unit acquired weakness (ICU-AW) and poor lung hygiene. In order to solve these two problems and increase the weaning rate, early mobilization (EM) and chest physiotherapy (CPT) are considered as possible strategy to attain the goal. According to previous articles, lacking of control group and small sample size made it difficult to confirm the true effect of EM and CPT on prolong weaning patients. Thus, the aims of this articles are discussing the influence from EM with CPT on weaning rate and other hospitalization outcomes with larger sample sizes and control group.


Eligibility criteria: Inclusion Criteria:

* The subjects' data which met the inclusion criteria are: 1. Age\>20 2. Patient with or without 3. Patient who met the criteria of received physiotherapy (Figure 1.) 4. No usage of life support device such as ECMO and so on. 5. Continuous mechanical ventilator use over 21 days.

Exclusion Criteria:

* The exclusion criteria are 1. Patients diagnosed as brain death 2. Patients who were ventilator dependent before admission 3. Patients who were against advice discharge under critical condition. 4. Patients received emergency intervention during course. 5. Patient who didn't meet the criteria of received physiotherapy (Figure 1.).

Primary outcomes:
measure: Weaning success rate
timeFrame: up to 6 weeks in respiratory care center
Secondary outcomes:
measure: RCC mortality rate
timeFrame: up to 6 weeks in respiratory care center
measure: hospital mortality rate
timeFrame: up to 6 weeks in respiratory care center
measure: discharge to home rate
timeFrame: after 6 weeks in respiratory care center
measure: total mechanical ventilator use
timeFrame: up to 6 weeks in respiratory care center
measure: RCC days of stay
timeFrame: up to 6 weeks in respiratory care center
measure: total hospital days of stay
timeFrame: up to 10 weeks in the hospital
Other outcomes:
Locations:
city: Taoyuan
country: Taiwan
facility: Taoyaun General Hospital, Ministry of Wealth and Health
state: Taoyuan Dist.
Study officials:
References: