Clinical trial NCT05204953: Mean Platelet Volume and Its Relation to Risk Stratification of Myelodysplastic Syndromes
Official title: Mean Platelet Volume and Its Relation to Risk Stratification of Myelodysplastic Syndromes
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Myelodysplastic Syndromes
Lead sponsor: Assiut University
Sponsor class: OTHER
First posted: 2022-01-24
Enrollment: 71
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: CASE_CONTROL
Time perspective: CROSS_SECTIONAL
Sampling method: NON_PROBABILITY_SAMPLE
Study population: All patients diagnosed to have myelodysplastic syndromes

Brief summary: The myelodysplastic syndromes (MDS) are a group of myeloid neoplasms characterized by abnormal differentiation and maturation of myeloid cells, reduced bone marrow (BM) function, and a genetic instability with enhanced risk to transform to secondary acute myeloid leukemia, AML

Detailed description: The diagnosis of MDS is an effort that requires clinicians and pathologists to work together. A patient's life, livelihood and outlook can be profoundly affected by the terms used by the treating physician. The typical presentation is unexplained anemia, leukopenia and/or thrombocytopenia, in an older patients (median age ≥ 70 years). However, thrombocytosis may be associated with the 5q-deletion syndrome or in selected patients with refractory anemia with ringed sideroblasts syndrome . The white count may be elevated in MDS / myeloproliferative disorder overlap syndromes particularly in chronic myelomonocytic leukemia, CMML.

MDS remains among the most challenging of the myeloid neoplasms to diagnose and classify, particularly in cases in which the blast percentage is not increased in the peripheral blood or bone marrow. Diagnostic problems can arise when the clinical and laboratory findings suggest MDS, but the morphologic findings are inconclusive; when there is secondary dysplasia caused by nutritional deficiencies, medications, toxins, growth factor therapy, inflammation or infection; or when marrow hypocellularity or myelofibrosis obscures the underlying disease process .

The prognosis of MDS is determined by several factors. Revised International Prognostic Scoring System (IPSS-R) for MDS divides patients into very low, low, intermediate, high and very high risk groups. Five factors (the percentage of bone marrow myeloblasts, the diagnostic cytogenetics, the hemoglobin level, the platelet count and the absolute neutrophilic count) are used to generate a prognostic score .

Eligibility criteria: Inclusion Criteria:

* All patients diagnosed to have myelodysplastic syndromes

Exclusion Criteria:

* no

Primary outcomes:
measure: mean platelet volume
timeFrame: at diagnosis (baseline)
Secondary outcomes:
measure: risk stratification of MDS patients
timeFrame: at diagnosis (baseline)
measure: relation of MPV to risk stratification
timeFrame: at diagnosis (baseline)
Other outcomes:
Locations:
Study officials:
affiliation: Assiut University
name: youssreya A Ahmad, MD
role: STUDY_DIRECTOR
affiliation: Assiut University
name: Ahmad F Thabet, MD
role: STUDY_DIRECTOR
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