louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT05646342: PLR in a Good Helath After 24 Week of Preganancy
Official title: PLR in a Good Helath Women After 24 Week of Preganancy
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: ITV Sosu Aortique
Cardiac Output, High
PLR
Keywords: CO
PLR
ETT
Pregnanacy
Lead sponsor: Mohammed VI University Hospital
Sponsor class: OTHER
First posted: 2022-12-12
Enrollment: 60
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: Moroccan population

Brief summary: fluid resuscitation is one of the bases of strategies in ICU to take in charge patients , one of the technique to evaluate preload charge , is Passive leg raising, that allows reliable prediction of fluid responsiveness even in patients with spontaneous breathing activity or arrhythmias .

In recent years, hemodynamic response to passive leg raising (PLR) has been popularized as a dynamic test of preload responsiveness \[1\]. This manoeuvre provides an "auto-fluid challenge" which is rapid, transient and reversible. PLR transfers blood contained in the venous reservoir of the lower extremities to the central venous compartment leading to a transient increase in preload and an increase in cardiac output by Frank-Starling mechanism in preload responsive individuals.

untille now the usseuful of PLR in Pregnancy, and also The validity of dynamic measurements of preload to predict fluid response during pregnancy are note clear in littérature .

Detailed description: A total of 108 low-risk pregnant women and 54 healthy non-pregnant controls, aged \>18 years, participated in the study. Pregnant women attending for the second trimester routine ultrasound screening at 17-19 weeks of gestation were informed about the study and invited to participate if they had a low-risk pregnancy and ultrasound scan did not show any fetal or placental abnormality. Those who agreed were consecutively enrolled and an appointment was made for functional hemodynamic evaluation at 22-24 weeks of gestation. Exclusion criteria were any pre-existing medical condition that may have an effect on the course of pregnancy, and a previous history of preeclampsia, gestational diabetes, intrauterine fetal growth restriction or preterm delivery. Non-pregnant controls were recruited among the nursing, administrative and laboratory staff of the hospital and university. Healthy women of reproductive age were asked to attend for hemodynamic assessment during the follicular phase between day 5 and 10 of the menstrual cycle. Women with a previous history of pregnancy complication and those with a known disease or on regular medication were excluded. Examination was performed,

Eligibility criteria: Inclusion Criteria:

* All Pregnante Women in good health after 24 week of preganancy

Exclusion Criteria:

* All young women under 18 years old
* unhealthy women

Primary outcomes:
measure: PLR in a good helath after 24 week of preganancy
timeFrame: in all the 5 mounths
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
References:
Clinical trial NCT01906242: Hygiene Protocol of Complete Dentures
Official title: Hygiene Protocols for Cleaning Complete Dentures
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Denture Hygiene Protocol
Lead sponsor: Federal University of Pelotas
Sponsor class: OTHER
First posted: 2013-07-24
Enrollment: 40
Sex: ALL
Minimum age (years): 40
Maximum age (years): 90
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: CROSSOVER
Primary purpose: PREVENTION

Brief summary: Adequate denture hygiene is important to patient's oral health maintenance in particular because of Candida albicans, responsible for the development of denture stomatitis. The aim of this study is to conduct a randomized controlled trial seeking for the best hygiene protocols to be used in removable denture wearers. The null hypothesis tested is that there will be no difference among the denture hygiene protocols tested.


Eligibility criteria: Inclusion Criteria:

* Complete denture wearer
* healthy
* ability to comply with the experimental protocol

Exclusion Criteria:

* Candidiasis (thrush)
* use of antifungals, antibiotics or mouthwashes in the prior 3 months
* limited motor activity
* unhealthy

Primary outcomes:
measure: Amount of biofilm formed on the denture
timeFrame: 14 days
Secondary outcomes:
measure: Odor
timeFrame: 14 days
Other outcomes:
Locations:
city: Pelotas
country: Brazil
facility: School of Dentistry
state: Rio Grande Do Sul
Study officials:
affiliation: Federal University of Pelotas
name: Tatiana Pereira-Cenci, PhD
role: PRINCIPAL_INVESTIGATOR
affiliation: Federal University of Pelotas
name: Maximiliano S Cenci, PhD
role: STUDY_CHAIR
References:
Clinical trial NCT03112642: Nerve Stimulator for Patients With Upper Extremity Disease, Vascular or Orthopedic Surgery
Official title: Does the Use of a Nerve Stimulator Improve the Outcome of Ultrasound-Guided Supraclavicular Block (Anesthesia) for Upper Extremity Surgery?
Study type: INTERVENTIONAL
Overall status: TERMINATED
Phase: NA
Conditions: Other Biomechanical Lesions of Upper Extremity
Lead sponsor: Rutgers, The State University of New Jersey
Sponsor class: OTHER
First posted: 2017-04-13
Enrollment: 8
Sex: ALL
Minimum age (years): 21
Maximum age (years): 89
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: To help determine if there is improved pain relief when a device that makes an arm muscle move (nerve stimulator) is used to place a needle in the area above the collarbone to prevent feeling of pain (anesthesia) of the upper arm.

Detailed description: The Investigators will use the assessment of onset of motor and sensory block Q 5 minutes to distinguish the difference between blocks performed with ultrasound guidance with or without a nerve blockade monitor.

Eligibility criteria: Inclusion Criteria:

* Adult male and females 21 through 89
* Agree to study participation and signed the informed consent
* Scheduled for upper extremity surgery with ultrasound guided supraclavicular block -

Exclusion Criteria:

* Children
* Pregnant Women
* Persons with allergies to local anesthetics
* Persons with infections at or near site of needle insertion
* Patients with severe disturbance of cardiac rhythm and heart block
* Patients with severe respiratory compromise
* Patients requiring bilateral upper extremity anesthesia
* Patients with coagulopathy or medical anticoagulation
* Patients with traumatic nerve injury to neck or upper extremity
* Patients with preexisting neurological deficits in the distribution of the block
* Patients with previous surgery to the neck that may distort brachial plexus anatomy

Primary outcomes:
measure: Dermatomes With Complete Motor Block of the Upper Extremities at 30 Minutes
timeFrame: 30 minutes post block
Secondary outcomes:
Other outcomes:
measure: Dermatomes With Response to Fine Touch at 30 Minutes
timeFrame: 30 minutes post block
Locations:
city: New Brunswick
country: United States
facility: Robert Wood Johnson University Hospital
state: New Jersey
Study officials:
affiliation: Robert Wood Johnson University Hospital
name: William Grubb, DDS, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT04952142: Minimal Water Exchange Versus Left Water Exchange in Unsedated Colonoscopy
Official title: Minimal Water Exchange Versus Left Water Exchange in Unsedated Colonoscopy: a Randomized Controlled Trial.
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Water Exchange Colonoscopy
Keywords: water-aided colonoscopy
Lead sponsor: Ningbo No. 1 Hospital
Sponsor class: OTHER
First posted: 2021-07-07
Enrollment: 230
Sex: ALL
Minimum age (years): 18
Maximum age (years): 75
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: SINGLE_GROUP
Primary purpose: SUPPORTIVE_CARE

Brief summary: Minimal water exchange colonoscopy is theoretically more convenient and faster than water exchange colonoscopy. But few studies compared the differences between the two methods. Therefore, we attempted to evaluate the effect of minimal water exchange colonoscopy prospectively.


Eligibility criteria: Inclusion Criteria:

* Patients aged 18 to 75 years for unsedated colonoscopy for colorectal cancer screening, polyp surveillance, or polyp resection were enrolled.

Exclusion Criteria:

* Patients who underwent sedation or analgesia before colonoscopy, and were reluctant to cooperate or provide informed consent. Those who were suffering from too serious diseases to tolerate the examination. The intestinal segment was incomplete or the colonoscopy did not reach the cecum.

Primary outcomes:
measure: VRS-4 pain scores
timeFrame: 30 minutes.
Secondary outcomes:
measure: Adenoma detection rate.
timeFrame: 40 minutes.
Other outcomes:
Locations:
city: Ningbo
country: China
facility: Ningbo first hospital
state: Zhejiang
Study officials:
References:
Clinical trial NCT03353142: The Effects Of Equal Breathing On Pain Pressure Thresholds
Official title: The Effects Of Equal Breathing On Pain Pressure Thresholds In Individuals With Chronic Low Back Pain: A Pilot Study
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Chronic Low Back Pain
Lead sponsor: Hamilton Health Sciences Corporation
Sponsor class: OTHER
First posted: 2017-11-27
Enrollment: 30
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Intervention model description: Consecutive participants meeting eligibility criteria will be enrolled
Primary purpose: TREATMENT

Brief summary: Recent research has found that there is moderate evidence for the use of breathing exercises for treating chronic, non-specific low back pain. Researchers have found that there were significant improvements in pain and quality of life in those suffering with low back pain who completed a breathing program intervention. Researchers also found that healthy individuals had higher pain thresholds and tolerance following deep and slow breathing exercises.

There are numerous formats of breathing interventions, some interventions that have been used with individuals with chronic, non-specific low back pain include: deep breathing, yoga breathing, resisted inspiration, and breathe holding. There is moderate evidence to suggest the use of these interventions for managing chronic low back pain Another common breathing format is Equal-Ratio Breathing. This format requires an individual to inhale and exhale with the same duration while gradually increasing the duration of both. This breathing format can be easier for patients to perform given the simplicity of the equal inhalation to exhalation ratio.

This research is being done because Equal-Ratio Breathing has yet to be studied in individuals with chronic low back pain.


Eligibility criteria: Inclusion Criteria:

* Aged ≥ 18
* Chronic low back pain
* OHIP patient

Exclusion Criteria:

* Peripheral pain
* Peripheral neuropathy
* Chronic regional pain syndrome
* Alpha and Beta blocker medication use
* Patient does not wish to participate
* Completed or participated in a psychoeducational program at the clinic

Primary outcomes:
measure: Difference in pain pressure threshold
timeFrame: Pre-visit and Post-visit - same day
Secondary outcomes:
measure: Difference in heart rate
timeFrame: Pre-visit and Post-visit - same day
measure: Difference in blood pressure values
timeFrame: Pre-visit and Post-visit - same day
Other outcomes:
Locations:
city: Hamilton
country: Canada
facility: Michael G. DeGroote Pain Clinic, Hamilton Health Sciences
state: Ontario
Study officials:
References:
Clinical trial NCT03706742: STOP HCC: Mailed HCV Treatment Outreach Program for HCC Prevention
Official title: STOP-HCC Evidence-Based Hepatocellular Cancer Prevention Through Treatment of Hepatitis C Virus Infection
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Hepatitis C
HepatoCellular Carcinoma
Lead sponsor: University of Texas Southwestern Medical Center
Sponsor class: OTHER
First posted: 2018-10-16
Enrollment: 12386
Sex: ALL
Minimum age (years): 53
Maximum age (years): 74
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: SCREENING

Brief summary: Aim 1: The investigators will conduct a randomized controlled trial comparing two strategies to promote HCV screening, follow-up testing, and treatment among baby-boomers (i.e. persons born between 1945-1965): inreach with electronic medical record alerts and provider education vs. combination of inreach and provider education plus mailed outreach and patient navigation.

Aim 2: The investigators will evaluate patient navigation strategies to promote follow-up testing and treatment evaluation among non-baby boomer Parkland patients (i.e. born before 1945 or after 1965) who are either: a) HCV antibody positive but have not completed follow-up viral load testing or b) HCV viral load positive and who have not completed in-clinic treatment evaluation.


Eligibility criteria: Inclusion Criteria:

* born between 1945 and 1965
* ≥ 1 outpatient visit during 12 months prior to randomization at Parkland
* no prior HCV screening (prior HCV antibody, viral load, or genotype).
* any active medical coverage
* speaks Spanish or English

Exclusion Criteria:

* a life expectancy less than one year including end stage CHF, end stage COPD, metastatic cancer, and those who received a palliative care or hospice referral in the past year
* history of HCC.
* non-English or Spanish speakers
* no address or phone number on file

Primary outcomes:
measure: Hepatitis C Screening
timeFrame: 3 months
Secondary outcomes:
measure: Hepatitis C Screening
timeFrame: 12 months
measure: Hepatitis C Confirmation
timeFrame: 3 months
measure: Hepatitis C Linkage to care
timeFrame: 6 months
measure: Cost: Cost-per patient screened
timeFrame: 3 months
measure: Cost: Cost per-HCV diagnosis
timeFrame: 12 months
Other outcomes:
Locations:
city: Dallas
country: United States
facility: Parkland Hospital
state: Texas
Study officials:
References:
citation: Desai N, Rich NE, Jain MK, Blackwell JM, Murphy CC, Perryman P, McBryde J, Quirk L, Clark C, Villarreal D, Waljee AK, Gopal P, Singal AG. Randomized Clinical Trial of Inreach With or Without Mailed Outreach to Promote Hepatitis C Screening in a Difficult-to-Reach Patient Population. Am J Gastroenterol. 2021 May 1;116(5):976-983. doi: 10.14309/ajg.0000000000001085.
Clinical trial NCT06964542: Effect of Supervised in Comparison to Non-supervised Multicomponent Exercise Training on Balance and Quality of Life in Peripheral Diabetic Neuropathy
Official title: Effect of Supervised in Comparison to Non-supervised Multicomponent Exercise Training on Balance and Quality of Life in Peripheral Diabetic Neuropathy
Study type: INTERVENTIONAL
Overall status: RECRUITING
Phase: NA
Conditions: Peripheral Diabetic Neuropathy
Keywords: Endurance
Multicomponent exercise training
Diabetes Mellitus
Peripheral Diabetic Neuropathy
Lead sponsor: Foundation University Islamabad
Sponsor class: OTHER
First posted: 2025-05-09
Enrollment: 30
Sex: ALL
Minimum age (years): 55
Maximum age (years): 70
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: THIS STUDY IS A RANDOMIZED CONTROL TRIAL AND THE PURPOSE OF THIS STUDY IS TO DETERMINE THE effect of supervised in comparison to non-supervised multicomponent exercise training on balance and quality of life in peripheral diabetic neuropathy

Detailed description: Effect of exercises to assess the benefits on strength endurance, balance and mobility.

Peripheral Neuropathy aged 55-70 will be recruited in the study. The participants would be assessed through WHOQOL BREF, BERG BALANCE SCALE, TIME UP AND GO TEST .

Informed Consent will Be taken after which the participants will be recruited into the two groups, where one group will receive supervised exercise intervention while other group will receive non supervised exercise intervention

Eligibility criteria: Inclusion Criteria:

* Age 55-70 years (both male and female)
* Diagnosed patients of diabetes type 2, 10 years after disease
* Completely assessed with Michigan Neuropathy Screening Instrument (MNSI) score scale and patients fulfilling this criterion will be included in this study
* Patients who are fulfilling PARQ will be included in study

Exclusion Criteria:

* Hypoglycemia
* Patient having ischemic heart diseases will not be included
* unable to walk independent
* major orthopedic problems (e.g. lower limb fractures)
* Diagnosed neurological and psychological patients

Primary outcomes:
measure: Balance
timeFrame: 4 weeks
measure: Strength
timeFrame: 4 weeks
measure: ENDURANCE
timeFrame: 4 weeks
Secondary outcomes:
Other outcomes:
Locations:
city: Islamabad
country: Pakistan
facility: Foundation University College of Physical Thrapy
Study officials:
References:
Clinical trial NCT06742242: The Use of Non-ICG-Enhanced Lymphatic Vessels for LVA
Official title: The Use of Non-Indocyanine Green-Enhanced Lymphatic Vessels for Supermicrosurgical Lymphaticovenous Anastomosis: a Propensity-Score-Matched Outcome Analysis
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Lymphedema
Keywords: propensity score matching
LVA
Supermicrosurgery
lymphaticovenous anastomosis
lymphovenous bypass
Lead sponsor: Chang Gung Memorial Hospital
Sponsor class: OTHER
First posted: 2024-12-19
Enrollment: 106
Sex: ALL
Minimum age (years): 20
Maximum age (years): 100
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: TREATMENT

Brief summary: The aim of the present study was to investigate the impact of non-ICG(+) LVs on the outcomes after LVA compared to ICG(+) LVs with propensity-score-match analysis.

Detailed description: It is a common belief among lymphatic supermicrosurgeons that LVA should only be performed with indocyanine green-enhanced (ICG(+)) LVs since such LVs are considered functional and are suitable for achieving better outcomes. However, in moderate to advance lymphedema patients, the use of non-ICG(+) LVs are inevitable despite efforts to identified ICG(+) LVs with ICG lymphography10, magnetic resonance (MR) lymphangiography11, or ultrasound12. In a previous study, it was suggested that a non-ICG(+) but flow-positive LV should also be considered functional because the functionality of an LV should be determined by its capability to transport lymph instead of ICG(+) lymph. Therefore, non- ICG(+) but flow-positive LVs should also be used for LVA to maximize the outcome13. This hypothesis was further supported by a recent article emphasizing the concept of a lymphatic-based lymphosome14, where it has been demonstrated that a functional LV will not become ICG(+) when ICG is not injected in the region being drained by this particular LV. It offers an explanation as to why a supposedly functional LV is not enhanced by ICG.

Eligibility criteria: Inclusion Criteria:

* Patients diagnosed with lymphatic-related diseases at Kaohsiung Chang Gung Memorial Hospital from September 2015 to March 2023.
* Patients who underwent LVA for unilateral lower-limb lymphedema.

Exclusion Criteria:

* Primary lymphedema
* Bilateral lower limb lymphedema
* History of previous treatment for lymphedema (LVA, vascularized lymph node transfer (VLNT), liposuction, or excisional therapy such as the Charles procedure) - Those that were lost to follow-up.

Primary outcomes:
measure: Volume change after LVA.
timeFrame: 6/12 months
Secondary outcomes:
Other outcomes:
Locations:
city: Kaohsiung
country: Taiwan
facility: Kaohsiung Chang Gung Memorial Hospital
Study officials:
References:
Clinical trial NCT00260442: Egg Cholesterol Consumption, Blood Cholesterol and Skeletal Muscle Hypertrophy
Official title: Egg Cholesterol Consumption, Blood Cholesterol and Skeletal Muscle Hypertrophy
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: PHASE2
Conditions: Sarcopenia
Cardiovascular Disease
Keywords: sarcopenia
resistance training
strength training
skeletal muscle
elderly
cholesterol
aging
cardiovascular disease
nutrition
inflammation
lipids
Lead sponsor: Texas A&M University
Sponsor class: OTHER
First posted: 2005-12-01
Enrollment: 36
Sex: ALL
Minimum age (years): 50
Maximum age (years): 69
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: PREVENTION

Brief summary: The purpose of this study is to examine the effect of dietary cholesterol administered as whole egg or egg white (control)on muscle mass gain with resistance training in a young old population of men and women (age 50-69). It is hypothesized that dietary cholesterol will be significantly associated to muscle mass gain.

Detailed description: The primary objective of this proposal is to have 36 men and women (age 50-69) perform 12 weeks of resistance exercise training for the purpose of inducing skeletal muscle hypertrophy. These individuals will consume either 0, 1, or 3 whole eggs per day in a double-blind design to test the hypothesis that dietary cholesterol is essential for skeletal muscle hypertrophy. If so proven, this will confirm a very strong association between dietary cholesterol and hypertrophy observed in a previous study of 51 men and women (age 60-69). The current proposal is using a randomized double-blind, placebo controlled design to provide the most conclusive evidence that dietary cholesterol plays an essential role in skeletal muscle hypertrophy.

The secondary objective of this proposal is to test the hypothesis that increased dietary cholesterol consumption in the context of an exercise program does not alter blood cholesterol concentrations or other cardiovascular risk factors.

Eligibility criteria: Inclusion Criteria:

* men and women aged 50-69
* able to perform exercise testing and training

Exclusion Criteria:

* blood pressure \> 160/100
* cardiac arrhythmias
* cancer
* hernia
* aortic aneurysm
* kidney disease
* lung disease
* total cholesterol \> 240 mg/dl or \< 160 mg/dl
* current use of cholesterol lowering medications
* actively participating in \>1 hour per week of resistance training

Primary outcomes:
measure: Primary: Strength and muscle gain (DEXA)
timeFrame: after 12 weeks of resistance training
Secondary outcomes:
measure: Secondary: Blood lipids, inflammatory markers, blood pressure
timeFrame: after 12 weeks of resistance training
Other outcomes:
Locations:
city: College Station
country: United States
facility: Texas A&M University
state: Texas
Study officials:
affiliation: Texas A&M University
name: Steven E Riechman, PhD, MPH
role: PRINCIPAL_INVESTIGATOR
References: