Clinical trial NCT05701449: Prevention and Treatment of Perioperative Lung Injury in Elderly Patients
Official title: Prevention and Treatment of Perioperative Lung Injury in Elderly Patients
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Postoperative Pulmonary Complications
Elderly Patients
Lead sponsor: Wuhan Union Hospital, China
Sponsor class: OTHER
Collaborators: name: China-Japan Friendship Hospital
name: Taihe Hospital
name: Chinese PLA General Hospital
name: First Affiliated Hospital of Zhejiang University
name: First Affiliated Hospital of Guangxi Medical University
name: Qinghai People's Hospital
name: Shanxi Cardiovascular Hospital
name: Wuhan No.1 Hospital
name: Shiyan City Renmin Hospital
name: Dongfeng General Hospital of Chinese Medicine
name: Xiangyang Central Hospital
name: Xiangyang No.1 People's Hospital
name: Hubei University of Medicine
name: Yunxi Renmin Hospital
name: Yunyang Renmin Hospital
name: Zhuxi Renmin Hospital
name: Danjiangkou First Hospital
name: Shiyan Integrated Traditional and Western Medicine Hospital
name: Shiyan Traditional Chinese Medicine Hospital
First posted: 2023-01-27
Enrollment: 5000
Sex: ALL
Minimum age (years): 65
Standard ages: OLDER_ADULT
Observational model: COHORT
Time perspective: OTHER
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Patients aged 65 years or older

Brief summary: This study aims to verify the prediction model of postoperative pulmonary complications by collecting clinical information on elderly patients. In addition, the incidence of postoperative pulmonary complications in elderly patients before and after using the prediction model was compared.

Detailed description: More than 300 million major operations are performed worldwide each year, and older patients account for about a third of elective operations. Compared with young people, the elderly are more prone to postoperative complications due to age-related degeneration of the physiological functions of various organs and tissues. Postoperative pulmonary complications, including pneumonia, atelectasis, and respiratory failure, are common. Even mild pulmonary complications can lead to the prolonged hospital stay and increased postoperative mortality.

Although there have been many studies on postoperative lung complications, there have been few studies on elderly patients. In our country, the real incidence data of elderly patients after a perioperative period of pulmonary complications, the lack of effective prevention, intervention measures, and targeted prevention and treatment technology, these reasons lead to the clinical diagnosis and treatment of elderly patients after a perioperative period of pulmonary complications are very difficult. Therefore, the research team intends to verify the established prediction model of postoperative pulmonary complications and compare the incidence of postoperative pulmonary complications in elderly patients before and after using the prediction model.

Eligibility criteria: Inclusion Criteria:

1. Age 65 years or older
2. receiving invasive ventilation during general anesthesia for surgery

Exclusion Criteria:

1. preoperative mechanical ventilation
2. procedures related to a previous surgical complication
3. a second operation after surgery within one week
4. organ transplantation
5. discharged within 24 hours after surgery

Primary outcomes:
measure: Postoperative pulmonary complications
timeFrame: within one week after surgery
Secondary outcomes:
measure: Length of postoperative hospital stay
timeFrame: 6 weeks after surgery
measure: Postoperative Death
timeFrame: 6 weeks after surgery
Other outcomes:
Locations:
Study officials:
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