Clinical trial NCT00887536: A Clinical Trial Comparing the Combination of TC Plus Bevacizumab to TC Alone and to TAC for Women With Node-Positive or High-Risk Node-Negative, HER2-Negative Breast Cancer
Official title: A Phase III Clinical Trial Comparing the Combination of TC Plus Bevacizumab to TC Alone and to TAC for Women With Node-Positive or High-Risk Node-Negative, HER2-Negative Breast Cancer
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE3
Conditions: Breast Cancer
Keywords: National Surgical Adjuvant Breast and Bowel Project (NSABP)
Taxotere
Docetaxel
Doxorubicin
Cyclophosphamide
Bevacizumab
Breast Neoplasms
Adenocarcinoma
Breast Diseases
Carcinoma
HER2 negative
Node negative
High risk node positive
Adjuvant Therapy
Lead sponsor: NSABP Foundation Inc
Sponsor class: NETWORK
Collaborators: name: Genentech, Inc.
name: US Oncology Research
First posted: 2009-04-24
Enrollment: 1613
Sex: FEMALE
Minimum age (years): 18
Maximum age (years): 70
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The main purpose of this study is to learn if adding bevacizumab to standard treatment with chemotherapy (docetaxel, doxorubicin, and cyclophosphamide) for early stage HER2-negative breast cancer will prevent breast cancer from returning. A second purpose of this study is to learn if adding bevacizumab to treatment with chemotherapy will help women with HER2-negative breast cancer live longer. The researchers also want to learn about the side effects of the combination of drugs used in this study.

Detailed description: The B-46-I/07132 study, a multicenter, open-label, randomized Phase III, adjuvant therapy trial, will compare the value of adding bevacizumab to a non-anthracycline-based chemotherapy regimen relative to the same chemotherapy without bevacizumab and relative to an anthracycline-based chemotherapy regimen in women with resected node-positive or high-risk node-negative, HER2-negative breast cancer. This trial will determine whether the addition of bevacizumab to a regimen of docetaxel and cyclophosphamide (TCB) improves invasive disease-free survival relative to docetaxel and cyclophosphamide alone (TC). A secondary aim will be to determine whether the addition of bevacizumab to TC improves invasive disease-free survival compared to a regimen of docetaxel, doxorubicin, and cyclophosphamide (TAC). Other secondary aims include whether TCB improves disease-free survival, overall survival, and recurrence-free interval relative to TC alone and to TAC. The toxicities of the three regimens will also be compared.

Patients in the B-46-I/07132 study will be randomized to one of three treatment regimens: Group 1 patients will receive 6 cycles of TAC administered every 21 days (docetaxel 75 mg/m2, doxorubicin 50 mg/m2, and cyclophosphamide 500 mg/m2); Group 2 patients will receive 6 cycles of TC administered every 21 days (docetaxel 75 mg/m2, cyclophosphamide 600 mg/m2); and Group 3 patients will receive 6 cycles of TCB every 21 days with bevacizumab therapy continuing every 21 days after completion of chemotherapy until 1 year following the first dose (docetaxel 75 mg/m2, cyclophosphamide 600 mg/m2, and bevacizumab 15 mg/kg). Primary prophylaxis with pegfilgrastim or filgrastim is required for Group 1 patients (optional for patients in Groups 2 and 3). Patients will also receive adjuvant radiation therapy as clinically indicated and endocrine therapy for hormone receptor-positive tumors.

Tumor samples will be submitted for correlative science studies to evaluate predictors of study therapy benefit. Submission of a tumor sample is a study requirement for all patients.

Eligibility criteria: Inclusion Criteria:

* Patients must be female.
* The patient must be greater than or equal to 18 years of age and less than or equal to 70 years of age.
* The patient must have an Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1.
* The tumor must be unilateral invasive adenocarcinoma of the breast on histologic examination.
* The breast cancer must be HER2-negative based on current American Society of Clinical Oncology (ASCO)/College of American Pathologists (CAP) Guideline Recommendations for Human Epidermal Growth Factor Receptor 2 Testing in Breast Cancer. If the result of the in situ hybridization testing (FISH, chromagen in situ hybridization (CISH), or other) is equivocal, the patient is eligible if there is no plan to administer HER2-targeted therapy.
* All of the following staging criteria (according to the 6th edition of the American Joint Committee on Cancer (AJCC) Cancer Staging Manual) must be met: By pathologic evaluation, primary tumor must be pT1-3; By pathologic evaluation, ipsilateral nodes must be pN0, pN1 (pN1mi, pN1a, pN1b, pN1c), pN2a, pN3a, or pN3b. If pN0, at least one of the following criteria must be met: ER negative and PgR negative; or Pathologic tumor size greater than 2.0 cm; or T1c (pathologic tumor size greater than 1.0 cm but less than or equal to 2.0 cm) and ER positive (PgR status may be positive or negative) and either Oncotype DX® Recurrence Score of greater than or equal to 25 or grade 3 histology.
* Patients must have undergone either a total mastectomy or breast-conserving surgery (lumpectomy).
* For patients who undergo lumpectomy, the margins of the resected specimen must be histologically free of invasive tumor and DCIS as determined by the local pathologist. If pathologic examination demonstrates tumor at the line of resection, additional operative procedures must be performed to obtain clear margins. If tumor is still present at the resected margin after re-excision(s), the patient must undergo total mastectomy to be eligible. (Patients with margins positive for lobular carcinoma in situ \[LCIS\] are eligible without additional resection.)
* For patients who undergo mastectomy, margins must be histologically free of invasive tumor and DCIS.
* Patients must have completed one of the following procedures for evaluation of pathologic nodal status: Sentinel lymphadenectomy alone if pathologic nodal staging based on sentinel lymphadenectomy is pN0, pN1mi, or pN1b; Sentinel lymphadenectomy followed by removal of additional non-sentinel lymph nodes if the sentinel node (SN) is positive; or Axillary lymphadenectomy without SN isolation procedure.
* The interval between the last surgery for breast cancer (treatment or staging) and randomization must be at least 28 days but no more than 84 days.
* Patients must have ER analysis performed on the primary tumor prior to randomization. If ER analysis is negative, then PgR analysis must also be performed. (Either a core biopsy or surgical resection specimen can be used for ER/PgR testing.)
* The most recent postoperative blood counts must meet the following criteria: Absolute neutrophil count (ANC) must be greater than or equal to 1200/mm3; platelet count must be greater than or equal to 100,000/mm3; and hemoglobin must be greater than or equal to 10 g/dL.
* The following criteria for evidence of adequate hepatic function must be met based on the results of the most recent postoperative tests: total bilirubin must be less than or equal to upper limits of normal (ULN)for the lab unless the patient has a bilirubin elevation less than ULN to 1.5 x ULN due to Gilbert's disease or similar syndrome involving slow conjugation of bilirubin; and alkaline phosphatase must be less than or equal to 2.5 x ULN for the lab; and AST must be less than or equal to 1.5 x ULN for the lab. Alkaline phosphatase and aspartate transaminase (AST) may not both be greater than the ULN. For example, if the alkaline phosphatase is greater than the ULN but less than or equal to 2.5 x ULN, then the AST must be less than or equal to the ULN. If the AST is greater than the ULN but less than or equal to 1.5 x ULN, then the alkaline phosphatase must be less than or equal to ULN.
* Patients with AST or alkaline phosphatase greater than ULN are eligible for inclusion in the study if liver imaging (CT, MRI, PET-CT, or PET scan) does not demonstrate metastatic disease and the requirements for adequate hepatic function are met.
* Patients with alkaline phosphatase that is greater than ULN but less than or equal to 2.5 x ULN are eligible for inclusion in the study if a bone scan, PET-CT, or PET scan does not demonstrate metastatic disease.
* The most recent postoperative serum creatinine must be less than or equal to ULN for the lab.
* A urine sample must be tested for proteinuria by the dipstick method. Eligibility must be based on the most recent postoperative test result(s) performed within 6 weeks prior to randomization. Urine dipstick must indicate 0-1+ protein. If dipstick reading is greater than or equal to 2+, a 24-hour urine specimen must be collected and must demonstrate less than 1 gram of protein.
* Left ventricular ejection fraction (LVEF) assessment by 2-D echocardiogram or multigated acquisition (MUGA) scan must be performed within 90 days prior to randomization. The LVEF must be greater than or equal to 50% regardless of the facility's lower limits of normal (LLN).

Exclusion Criteria:

* T4 tumors including inflammatory breast cancer.
* Definitive clinical or radiologic evidence of metastatic disease.
* Synchronous or metachronous contralateral invasive breast cancer. (Patients with synchronous and/or metachronous contralateral DCIS are eligible.)
* Any history of ipsilateral invasive breast cancer or ipsilateral DCIS.
* History of non-breast malignancies within 5 years prior to randomization, except for the following: carcinoma in situ of the cervix, colorectal carcinoma in situ, melanoma in situ, and basal cell and squamous cell carcinomas of the skin.
* Previous therapy with anthracyclines, taxanes, or bevacizumab for any malignancy.
* Chemotherapy administered for the currently diagnosed breast cancer prior to randomization.
* Continued therapy with any hormonal agent such as raloxifene or tamoxifen (or other SERM) or an aromatase inhibitor. (Patients are eligible if these medications are discontinued prior to randomization.)
* Any sex hormonal therapy, e.g., birth control pills, ovarian hormone replacement therapy. Patients are eligible if these medications are discontinued prior to randomization.
* Active hepatitis B or hepatitis C with abnormal liver function tests.
* Cardiac disease (history of and/or active disease) that would preclude the use of the drugs included in the treatment regimens. This includes but is not confined to 1) Active cardiac disease: angina pectoris that requires the use of anti-anginal medication; ventricular arrhythmias except for benign premature ventricular contractions; supraventricular and nodal arrhythmias requiring a pacemaker or not controlled with medication; conduction abnormality requiring a pacemaker; valvular disease with documented compromise in cardiac function; and symptomatic pericarditis, 2) History of cardiac disease: myocardial infarction documented by elevated cardiac enzymes or persistent regional wall abnormalities on assessment of left ventricular (LV) function; history of documented congestive heart failure (CHF); and documented cardiomyopathy.
* Uncontrolled hypertension defined as systolic BP greater than 150 mmHg or diastolic BP greater than 90 mmHg, with or without anti-hypertensive medication. Patients with initial BP elevations are eligible if initiation or adjustment of BP medication lowers pressure to meet entry criteria.
* History of hypertensive crisis or hypertensive encephalopathy.
* History of transient ischemic attack (TIA) or cerebrovascular accident (CVA).
* History of any arterial thrombotic event within 12 months prior to randomization.
* Symptomatic peripheral vascular disease.
* Intrinsic lung disease resulting in dyspnea.
* Unstable diabetes mellitus.
* Active infection or chronic infection requiring suppressive antibiotics.
* History of a major organ allograft or condition requiring chronic immunosuppression, e.g., kidney, liver, lung, heart, bone marrow transplant, or autoimmune diseases. (Patients who have received corneal transplants, cadaver skin, or bone transplants are eligible.)
* Any significant bleeding within 180 days prior to randomization, exclusive of menorrhagia in premenopausal women.
* Non-healing wound, skin ulcers, or incompletely healed bone fracture.
* Major surgical procedure, open biopsy, or significant traumatic injury within 28 days prior to the planned start of study therapy.
* Anticipation of need for major surgical procedures during study therapy and for at least 3 months following completion of bevacizumab.
* Gastroduodenal ulcer(s) documented by endoscopy to be active within 6 months before randomization.
* History of GI perforation, abdominal fistulae, or intra-abdominal abscess.
* Known bleeding diathesis or coagulopathy.
* Requirement for therapeutic doses of coumadin or equivalent.
* Sensory/motor neuropathy greater than or equal to grade 2, as defined by the NCI Common Terminology Criteria for Adverse Events (CTCAE) v3.0.
* Conditions that would prohibit administration of corticosteroids.
* Chronic daily treatment with corticosteroids (dose of greater than or equal to 10 mg/day methylprednisolone equivalent) (excluding inhaled steroids).
* History of hypersensitivity reaction to drugs formulated with polysorbate 80.
* Pregnancy or lactation at the time of study entry.
* Other non-malignant systemic disease that would preclude the patient from receiving study treatment or would prevent required follow-up.
* Psychiatric or addictive disorders or other conditions that, in the opinion of the investigator, would preclude the patient from meeting the study requirements.
* Use of any investigational product within 4 weeks prior to randomization.

Primary outcomes:
measure: Invasive disease-free survival(IDFS)relative to the TAC chemotherapy regimen alone
timeFrame: Every 12 months until recurrence
Secondary outcomes:
measure: Invasive disease-free survival (IDFS) relative to the TAC chemotherapy regimen
timeFrame: Every 12 months until recurrence
measure: Disease-free survival (DFS-DCIS) relative to the TC alone regimen
timeFrame: Every 12 months until recurrence
measure: Overall survival (OS) relative to the TC alone regimen
timeFrame: Every 12 months from randomization until death from any cause
measure: OS relative to the TAC regimen
timeFrame: Every 12 months from randomization until death from any cause
measure: Recurrence-free interval (RFI) relative to the TC alone regimen
timeFrame: Every 12 months, from randomization to local, regional, or distant recurrence
measure: RFI relative to the TAC regimen
timeFrame: Every 12 months, from randomization to local, regional, or distant recurrence
measure: Develop molecular predictive markers for the degree of benefit from TCB over TC or TAC
timeFrame: 6 years
measure: Provide the efficacy data from Group 1 patients and Group 2 patients enrolled in B-46-I/07132 to US Oncology Research, Inc. (USOR) for a planned combined analysis with efficacy data from patients receiving the same regimens in the USOR 06-090 trial
timeFrame: 10 years
measure: Toxicity associated with each of the regimens
timeFrame: Every 6 months
measure: Determine the role of topoisomerase II alpha (TOP2A) in prognosis and prediction of degree of benefit from TAC over TC
timeFrame: 6 years
measure: Develop predictive markers for benefit from doxorubicin
timeFrame: 6 years
Other outcomes:
Locations:
city: Bessemer
country: United States
facility: Birmingham Hematology and Oncology
state: Alabama
city: Birmingham
country: United States
facility: Birmingham Hematology and Oncology
state: Alabama
city: Birmingham
country: United States
facility: Birmingham Hematology and Oncology - Brookwood
state: Alabama
city: Birmingham
country: United States
facility: Birmingham Hematology and Oncology - Princeton
state: Alabama
city: Birmingham
country: United States
facility: Birmingham Hematology and Oncology - Montclair
state: Alabama
city: Birmingham
country: United States
facility: Birmingham Hematology and Oncology - Pilot
state: Alabama
city: Huntsville
country: United States
facility: Clearview Cancer Institute- Huntsville
state: Alabama
city: Flagstaff
country: United States
facility: Northern Arizona Hematology & Onclogy Associates
state: Arizona
city: Green Valley
country: United States
facility: Arizona Oncolocy (CASA-Green Valley)
state: Arizona
city: Oro Valley
country: United States
facility: Arizona Oncology (CASA- Oro Valley)
state: Arizona
city: Phoenix
country: United States
facility: Hematology Oncology Associates
state: Arizona
city: Prescott Valley
country: United States
facility: Northern Arizona Hematology & Oncology Associates
state: Arizona
city: Safford
country: United States
facility: Arizona Oncology (CASA-Safford)
state: Arizona
city: Scottsdale
country: United States
facility: Hematology Oncology Associates
state: Arizona
city: Sedona
country: United States
facility: Northern Arizona Hematology & Oncology Associates
state: Arizona
city: Tucson
country: United States
facility: Arizona Oncology Associates - Rudasill
state: Arizona
city: Tucson
country: United States
facility: Arizona Oncology Associates - Carondelet
state: Arizona
city: Tucson
country: United States
facility: Arizona Oncology (CASA-Craycroft)
state: Arizona
city: Tucson
country: United States
facility: Arizona Oncology (CASA-Office Only)
state: Arizona
city: Tucson
country: United States
facility: Arizona Oncology - CASA St. Mary's
state: Arizona
city: Alhambra
country: United States
facility: Central Hematology/Oncology Medical Group, Inc.
state: California
city: Antioch
country: United States
facility: Kaiser Permanente Deer Valley Med Center
state: California
city: Bakersfield
country: United States
facility: Comp Blook and Cancer Center
state: California
city: Escondido
country: United States
facility: Southwest Cancer Care (E. Grand)
state: California
city: Fremont
country: United States
facility: Kaiser Permanente Fremont
state: California
city: Fullerton
country: United States
facility: St. Jude Heritage Healthcare
state: California
city: Hayward
country: United States
facility: Kaiser Permanente Medical Center - Hayward
state: California
city: Huntington Beach
country: United States
facility: Pacific Shores Medical Group
state: California
city: Irvine
country: United States
facility: Southern California Permanente Medical Group
state: California
city: La Verne
country: United States
facility: Wilshire Oncology Medical Group (Business Office)
state: California
city: Lancaster
country: United States
facility: Antelope Valley Cancer Center
state: California
city: Long Beach
country: United States
facility: Breastlink Medical Group, Incorporated at Long Beach Memorial Medical Center
state: California
city: Long Beach
country: United States
facility: Todd Cancer Institute at Long Beach Memorial Med Cent
state: California
city: Long Beach
country: United States
facility: Pacific Shores Medical Group
state: California
city: Los Alamitos
country: United States
facility: Pacific Shores Medical Group
state: California
city: Mission Hills
country: United States
facility: TORI- N Valley Hematology Oncology Med Group
state: California
city: Montebello
country: United States
facility: TORI - Oncology Care Medical Assoc.
state: California
city: Murrieta
country: United States
facility: Southwest Cancer Care (Medical Center)
state: California
city: Northridge
country: United States
facility: NValley Hematology/Oncology Medical Group
state: California
city: Oakland
country: United States
facility: Kaiser Permanente-Oakland
state: California
city: Orange
country: United States
facility: St. Joseph Hospital
state: California
city: Oxnard
country: United States
facility: Ventura County Hematology-Oncology Specialists
state: California
city: Palo Alto
country: United States
facility: Stanford University Medical Center
state: California
city: Redwood City
country: United States
facility: Kaiser Permanente Medical Center - Redwood City
state: California
city: Richmond
country: United States
facility: Kaiser Permanente Medical Center - Richmond
state: California
city: Roseville
country: United States
facility: Sutter Roseville Medical Center
state: California
city: Roseville
country: United States
facility: Kaiser Permanente Roseville
state: California
city: Sacramento
country: United States
facility: Sutter Medical Center
state: California
city: Sacramento
country: United States
facility: Kaiser Permanente, South Sacramento
state: California
city: Sacramento
country: United States
facility: Kaiser Permanente Medical Center - Sacramento
state: California
city: San Diego
country: United States
facility: Kaiser Permanente-San Diego
state: California
city: San Francisco
country: United States
facility: Kaiser Permanente Medical Center - San Francisco Geary Campus
state: California
city: San Gabriel
country: United States
facility: TORI - Oncology Care Med Assoc
state: California
city: San Jose
country: United States
facility: Kaiser Permanente Santa Teresa
state: California
city: San Rafael
country: United States
facility: Kaiser Permanente San Rafael
state: California
city: Santa Barbara
country: United States
facility: Santa Barbara Hematology Oncology Medical Group
state: California
city: Santa Barbara
country: United States
facility: Santa Barbara II (Samsum Clinic) - TORI
state: California
city: Santa Clara
country: United States
facility: Kaiser Permanente Medical Center - Santa Clara Kiely Campus
state: California
city: Santa Maria
country: United States
facility: Central Coast Medical Oncology Corporation
state: California
city: Santa Rosa
country: United States
facility: Kaiser Permanente Medical Center - Santa Rosa
state: California
city: Solvang
country: United States
facility: Santa Barbara Hematology/Oncology Medical Group, Inc
state: California
city: South San Francisco
country: United States
facility: Kaiser Permanente-South San Francisco
state: California
city: Stockton
country: United States
facility: Kaiser Permanente Medical Facility - Stockton
state: California
city: Sylmar
country: United States
facility: Olive View/UCLA Medical Center
state: California
city: Vacaville
country: United States
facility: Kaiser Permanente Medical Center Vacaville
state: California
city: Vallejo
country: United States
facility: Kaiser Permanente Medical Center - Vallejo
state: California
city: Walnut Creek
country: United States
facility: Kaiser Permanente Medical Center - Walnut Creek
state: California
city: Westlake Village
country: United States
facility: Trivalley Oncology Hematology
state: California
city: Westlake Village
country: United States
facility: Westlake Infusion Center
state: California
city: Whittier
country: United States
facility: TORI - Oncology Care Med Assoc
state: California
city: Aurora
country: United States
facility: Medical Center of Aurora
state: Colorado
city: Aurora
country: United States
facility: Rocky Mountain Cancer Center
state: Colorado
city: Boulder
country: United States
facility: Rocky Mountain Cancer Centers - Boulder
state: Colorado
city: Colorado Springs
country: United States
facility: Penrose/St. Francis Healthcare System
state: Colorado
city: Colorado Springs
country: United States
facility: Rocky Mountain Cancer Center at the Pivillion- Fontanero
state: Colorado
city: Colorado Springs
country: United States
facility: Rocky Mountain Cancer Center - CO Springs
state: Colorado
city: Denver
country: United States
facility: Kaiser Permanente-Franklin
state: Colorado
city: Denver
country: United States
facility: CCOP - Colorado Cancer Research Program, Inc.
state: Colorado
city: Denver
country: United States
facility: Porter Adventist Hospital
state: Colorado
city: Denver
country: United States
facility: Exempla St. Joseph Hospital
state: Colorado
city: Denver
country: United States
facility: Rocky Mountain Cancer Center - Midtown
state: Colorado
city: Denver
country: United States
facility: Rocky Mountain Cancer Center - 9th Avenue
state: Colorado
city: Denver
country: United States
facility: Rocky Mountain Cancer Center - Rose
state: Colorado
city: Denver
country: United States
facility: University of Colorado
state: Colorado
city: Edwards
country: United States
facility: Shaw Regional Cancer Center
state: Colorado
city: Englewood
country: United States
facility: Swedish Medical Center
state: Colorado
city: Fort Collins
country: United States
facility: Front Range Cancer Specialists
state: Colorado
city: Fort Collins
country: United States
facility: Poudre Valley Hospital
state: Colorado
city: Grand Junction
country: United States
facility: St. Mary's Hospital and Medical Center
state: Colorado
city: Grand Junction
country: United States
facility: St. Mary's Regional Cancer Center at St. Mary's Hospital and Medical Center
state: Colorado
city: Greeley
country: United States
facility: North Colorado Medical Center
state: Colorado
city: Lafayette
country: United States
facility: Kaiser Permanente Rock Creek
state: Colorado
city: Lakewood
country: United States
facility: Rocky Mountain Cancer Center
state: Colorado
city: Littleton
country: United States
facility: Rocky Mountain Cancer Center - Dry Creek
state: Colorado
city: Lone Tree
country: United States
facility: Rocky Mountain Cancer Center- Sky Ridge
state: Colorado
city: Longmont
country: United States
facility: Rocky Mountain Cancer Center - Longmont
state: Colorado
city: Loveland
country: United States
facility: McKee Medical Center
state: Colorado
city: Parker
country: United States
facility: Rocky Mountain Cancer Center
state: Colorado
city: Thornton
country: United States
facility: Rocky Mountain Cancer Centers
state: Colorado
city: Wheat Ridge
country: United States
facility: Exempla Lutheran Medical Center
state: Colorado
city: Farmington
country: United States
facility: University of Connecticut
state: Connecticut
city: Hartford
country: United States
facility: Hartford Hospital
state: Connecticut
city: Washington
country: United States
facility: Washington Regional Cancer Center
state: District of Columbia
city: Washington
country: United States
facility: Sibley Memorial Hospital
state: District of Columbia
city: Bonita Springs
country: United States
facility: SCRI - Florida Cancer Specialists- Bonita Springs
state: Florida
city: Bradenton
country: United States
facility: SCRI - Florida Cancer Specialists - Bradenton
state: Florida
city: Brandon
country: United States
facility: Florida Cancer Specialists
state: Florida
city: Cape Coral
country: United States
facility: SCRI Florida Cancer Specialists - Cape Coral (1708)
state: Florida
city: Cape Coral
country: United States
facility: SCRI Florida Cancer Specialists - Cape Coral (811)
state: Florida
city: Clearwater
country: United States
facility: Morton Plant Mease Health Care
state: Florida
city: Englewood
country: United States
facility: SCRI Florida Cancer Specialists - Englewood
state: Florida
city: Fort Lauderdale
country: United States
facility: Holy Cross Hospital
state: Florida
city: Fort Myers
country: United States
facility: SCRI Florida Cancer Specialists - Fort Myers (Hampshire)
state: Florida
city: Fort Myers
country: United States
facility: SCRI Florida Cancer Specialists - Ft. Myers (Broadway)
state: Florida
city: Fort Myers
country: United States
facility: SCRI Florida Cancer Specialists- Fort Myers (Veronica)
state: Florida
city: Gainesville
country: United States
facility: University of Florida Shands Cancer Center
state: Florida
city: Hudson
country: United States
facility: Florida Cancer Institute - New Hope
state: Florida
city: Jacksonville
country: United States
facility: TORI-ICON - Shircl
state: Florida
city: Jacksonville
country: United States
facility: Baptist Cancer Institute - Jacksonville
state: Florida
city: Jacksonville
country: United States
facility: Integrated Community Oncology Network (ICON)
state: Florida
city: Jacksonville
country: United States
facility: TORI-ICON St.Aug
state: Florida
city: Jupiter
country: United States
facility: CCOP, Jupiter Medical Cener
state: Florida
city: Lady Lake
country: United States
facility: Ocala Oncology Center - Lady Lake
state: Florida
city: Melbourne
country: United States
facility: Melbourne International Medicine Associates
state: Florida
city: Miami Beach
country: United States
facility: CCOP - Mount Sinai Medical Center
state: Florida
city: Miami
country: United States
facility: Advanced Medical Specialties - AMS
state: Florida
city: Miami
country: United States
facility: Advanced Medical Specialists- Sunset
state: Florida
city: Miami
country: United States
facility: Advanced Medical Specialties - N Kendall (STE 300E)
state: Florida
city: Miami
country: United States
facility: Advanced Medical Specialties - N. Kendall (STE 905E)
state: Florida
city: Naples
country: United States
facility: SCRI Florida Cancer Specialists - Naples (Goodlette)
state: Florida
city: Naples
country: United States
facility: SCRI Florida Cancer Specialists - Naples (Pine)
state: Florida
city: New Port Richey
country: United States
facility: Florida Cancer Institute - New Hope
state: Florida
city: Ocala
country: United States
facility: Ocala Oncology Center
state: Florida
city: Ocoee
country: United States
facility: Cancer Centers of Florida, P.A.
state: Florida
city: Orange Park
country: United States
facility: Tori-Icon
state: Florida
city: Orlando
country: United States
facility: Florida Hospital
state: Florida
city: Orlando
country: United States
facility: Cancer Centers of Florida, P.A.
state: Florida
city: Orlando
country: United States
facility: MD Anderson Cancer Center
state: Florida
city: Port Charlotte
country: United States
facility: SCRI - Florida Cancer Specialists - Port Charlotte
state: Florida
city: Saint Augustine
country: United States
facility: Tori-Icon
state: Florida
city: Sarasota
country: United States
facility: SCRI Florida Cancer Specialists - Sarasota (Cattleman)
state: Florida
city: Sarasota
country: United States
facility: SCRI- Florida Cancer Specialists - Sarasota
state: Florida
city: Tampa
country: United States
facility: SCRI - Florida Cancer Specialists - Armenia
state: Florida
city: Tampa
country: United States
facility: SCRI - Florida Cancer Specialists - Tampa
state: Florida
city: Venice
country: United States
facility: SCRI Florida Cancer Specialists - Venice (Tamiami)
state: Florida
city: Venice
country: United States
facility: SCRI Florida Cancer Specilaists - Venice
state: Florida
city: Winter Park
country: United States
facility: Cancer Centers of Florida, P.A.
state: Florida
city: Albany
country: United States
facility: Phoebe Putney Memorial Hospital
state: Georgia
city: Austell
country: United States
facility: Northwest Georgia Oncology Centers
state: Georgia
city: Carrollton
country: United States
facility: Northwest Georgia Oncology Centers
state: Georgia
city: Dublin
country: United States
facility: Dublin Hematology/Oncology
state: Georgia
city: Lawrenceville
country: United States
facility: Suburban Hematology-Oncology Associates
state: Georgia
city: Marietta
country: United States
facility: Northwest Georgia Oncology Centers
state: Georgia
city: Ringgold
country: United States
facility: SCRI Chattanooga Oncol & Hematol Assoc, PC - Ringgold
state: Georgia
city: Savannah
country: United States
facility: Memorial Health University Medical Center
state: Georgia
city: Honolulu
country: United States
facility: University of Hawaii
state: Hawaii
city: Honolulu
country: United States
facility: Kaiser Permanente Hawaii - Moanalua Med Center
state: Hawaii
city: Arlington
country: United States
facility: Cancer Care & Hematology Specialists of Chicagoland
state: Illinois
city: Chicago
country: United States
facility: Rush University Medical Center
state: Illinois
city: Decatur
country: United States
facility: Decatur Memorial Hospital Cancer Care Institute
state: Illinois
city: Evanston
country: United States
facility: CCOP NorthShore University HealthSystem
state: Illinois
city: Harvey
country: United States
facility: Ingalls Memorial Hospital
state: Illinois
city: Hinsdale
country: United States
facility: Hinsdale Hematology Oncology Associates
state: Illinois
city: Naperville
country: United States
facility: Edward Hospital
state: Illinois
city: Niles
country: United States
facility: Cancer Care & Hematology Specialists of Chicagoland
state: Illinois
city: Park Ridge
country: United States
facility: Advocate Lutheran General Cancer Care Center
state: Illinois
city: Urbana
country: United States
facility: Carle Cancer Center, CCOP
state: Illinois
city: Urbana
country: United States
facility: Carle Foundation Hospital
state: Illinois
city: Winfield
country: United States
facility: Cancer Care and Hematology Specialists of Chicagoland
state: Illinois
city: Carmel
country: United States
facility: Central Indiana Cancer Centers
state: Indiana
city: Fishers
country: United States
facility: Central Indiana Cancer Centers
state: Indiana
city: Greenfield
country: United States
facility: Central Indiana Cancer Centers
state: Indiana
city: Indianapolis
country: United States
facility: Central Indiana Cancer Centers
state: Indiana
city: Indianapolis
country: United States
facility: Central Indiana Cancer Centers (E. County)
state: Indiana
city: Indianapolis
country: United States
facility: St. Vincent Hospital and Health Care Center
state: Indiana
city: Lafayette
country: United States
facility: Clarian Arnett Cancer Care
state: Indiana
city: Munster
country: United States
facility: Community Hospital
state: Indiana
city: Davenport
country: United States
facility: Genesis Medical Center
state: Iowa
city: Dubuque
country: United States
facility: Finley Hospital
state: Iowa
city: Iowa City
country: United States
facility: University of Iowa
state: Iowa
city: Sioux City
country: United States
facility: Mercy Medical Center - Sioux City
state: Iowa
city: Sioux City
country: United States
facility: Siouxland Hematology-Oncology Associates
state: Iowa
city: Sioux City
country: United States
facility: St. Luke's Regional Medical Center
state: Iowa
city: Waterloo
country: United States
facility: Covenant Cancer Treatment Center
state: Iowa
city: Kansas City
country: United States
facility: Kansas Cty Cancer Center - West
state: Kansas
city: Overland Park
country: United States
facility: Menorah Medical Center
state: Kansas
city: Overland Park
country: United States
facility: Kansas City Cancer Center (CBO)
state: Kansas
city: Overland Park
country: United States
facility: Kansas CityCancer Centers - Southwest
state: Kansas
city: Shawnee Mission
country: United States
facility: Kansas City Cancer Center, Shawnee Mission
state: Kansas
city: Crestview Hills
country: United States
facility: SCRI Oncology Hematology Care, Inc. Crestview Hills (CVH)
state: Kentucky
city: Lexington
country: United States
facility: University of Kentucky Medical Center
state: Kentucky
city: Louisville
country: United States
facility: NortonHealtcare Inc.
state: Kentucky
city: Louisville
country: United States
facility: Consultants in Blood Disorders and Cancer
state: Kentucky
city: Alexandria
country: United States
facility: Christus St. Frances Cabrini Hospital
state: Louisiana
city: Baton Rouge
country: United States
facility: Baton Rouge General Medical Center
state: Louisiana
city: New Orleans
country: United States
facility: Tulane University Medical Center
state: Louisiana
city: Bangor
country: United States
facility: Eastern Maine Medical Center
state: Maine
city: Baltimore
country: United States
facility: Mercy Medical Center
state: Maryland
city: Baltimore
country: United States
facility: St. Joseph's Medical Center
state: Maryland
city: Baltimore
country: United States
facility: Greater Baltimore Medical Center
state: Maryland
city: Baltimore
country: United States
facility: Franklin Square Hospital Center
state: Maryland
city: Bethesda
country: United States
facility: SCRI - Center for Cancer and Blood Disorders
state: Maryland
city: Bethesda
country: United States
facility: Suburban Hospital
state: Maryland
city: Chevy Chase
country: United States
facility: Chevy Chase Healthcare Management, LLC
state: Maryland
city: Columbia
country: United States
facility: Maryland Oncology Hematology PA
state: Maryland
city: Frederick
country: United States
facility: Frederick Memorial Hospital
state: Maryland
city: Owings Mills
country: United States
facility: Alliance Hematology Oncology PA
state: Maryland
city: Salisbury
country: United States
facility: Penisula Regional Medical Center
state: Maryland
city: Silver Spring
country: United States
facility: Holy Cross Hospital
state: Maryland
city: Westminster
country: United States
facility: Alliance Hematology Oncology PA
state: Maryland
city: Fall River
country: United States
facility: Saint Anne's Hospital
state: Massachusetts
city: Pittsfield
country: United States
facility: Berkshire Hematology Oncology, P.C.
state: Massachusetts
city: Ann Arbor
country: United States
facility: CCOP, St. Joseph Mercy Hospital
state: Michigan
city: Bay City
country: United States
facility: Bay Regional Medical Center
state: Michigan
city: Dearborn
country: United States
facility: CCOP - Oakwood Hospital and Medical Center
state: Michigan
city: Detroit
country: United States
facility: Henry Ford Health System
state: Michigan
city: Detroit
country: United States
facility: CCOP - St. John Hospital and Medical Center
state: Michigan
city: East Lansing
country: United States
facility: Michigan State University
state: Michigan
city: Flint
country: United States
facility: CCOP - Genesys Regional Hospital
state: Michigan
city: Flint
country: United States
facility: CCOP - Hurley Medical Center
state: Michigan
city: Flint
country: United States
facility: McLaren Regional Medical Center
state: Michigan
city: Jackson
country: United States
facility: CCOP - Allegiance Health
state: Michigan
city: Kalamazoo
country: United States
facility: Borgess Medical Center
state: Michigan
city: Kalamazoo
country: United States
facility: Bronson Methodist Hospital
state: Michigan
city: Kalamazoo
country: United States
facility: West Michigan Cancer Center
state: Michigan
city: Lansing
country: United States
facility: Ingham Regional Medical Center - Lansing
state: Michigan
city: Lansing
country: United States
facility: CCOP, Sparrow Health System
state: Michigan
city: Lapeer
country: United States
facility: Lapeer Regional Hospital
state: Michigan
city: Livonia
country: United States
facility: CCOP - St. Mary Mercy Hospital - Livonia
state: Michigan
city: Marquette
country: United States
facility: Marquette General Hospital
state: Michigan
city: Mount Clemens
country: United States
facility: Mount Clemens Regional Medical Center
state: Michigan
city: Owosso
country: United States
facility: Memorial Healthcare
state: Michigan
city: Pontiac
country: United States
facility: CCOP - St. Joseph Mercy Hospital - Oakland
state: Michigan
city: Port Huron
country: United States
facility: CCOP - St. Joseph Mercy Port Huron
state: Michigan
city: Royal Oak
country: United States
facility: CCOP, William Beaumont Hospital
state: Michigan
city: Saginaw
country: United States
facility: CCOP, St. Mary's Medical Center
state: Michigan
city: Southfield
country: United States
facility: Providence Hospital - Southfield
state: Michigan
city: Warren
country: United States
facility: CCOP, St. John Macomb Hospital
state: Michigan
city: Burnsville
country: United States
facility: Minnesota Oncology Hematology-Burnsville
state: Minnesota
city: Coon Rapids
country: United States
facility: Mercy and Unity Cancer Center at Mercy Hospital
state: Minnesota
city: Duluth
country: United States
facility: St. Luke's Hospital
state: Minnesota
city: Edina
country: United States
facility: Fairview Southdale Hospital
state: Minnesota
city: Edina
country: United States
facility: Minnesota Oncology Hematology-Edina
state: Minnesota
city: Fridley
country: United States
facility: Unity Hospital
state: Minnesota
city: Maplewood
country: United States
facility: Minnesota Oncology Hematology PA - Maplewood
state: Minnesota
city: Maplewood
country: United States
facility: St. John's Hospital Northeast/HealthEast, Inc.
state: Minnesota
city: Minneapolis
country: United States
facility: Minnesota Oncology Hematology-Minneapolis
state: Minnesota
city: Minneapolis
country: United States
facility: Abbott-Northwestern Hospital
state: Minnesota
city: Minneapolis
country: United States
facility: Hennepin County Medical Center - Minneapolis
state: Minnesota
city: Robbinsdale
country: United States
facility: North Memorial Health Care
state: Minnesota
city: Saint Louis Park
country: United States
facility: CCOP - Metro-Minnesota
state: Minnesota
city: Saint Louis Park
country: United States
facility: Park Nicollet Health Services
state: Minnesota
city: Saint Paul
country: United States
facility: Regions Hospital Cancer Care Center
state: Minnesota
city: Saint Paul
country: United States
facility: Minnesota Hematology Oncology-St. Paul
state: Minnesota
city: Woodbury
country: United States
facility: Minnesota Oncology Hematology
state: Minnesota
city: Columbia
country: United States
facility: Missouri Cancer Associates
state: Missouri
city: Columbia
country: United States
facility: University of Missouri-Ellis Fischel
state: Missouri
city: Kansas City
country: United States
facility: Kansas City Cancer Center - Central
state: Missouri
city: Kansas City
country: United States
facility: Saint Luke's Hospital
state: Missouri
city: Kansas City
country: United States
facility: CCOP - Kansas City
state: Missouri
city: Kansas City
country: United States
facility: Kansas City Cancer Center - South
state: Missouri
city: Kansas City
country: United States
facility: Research Medical Center
state: Missouri
city: Kansas City
country: United States
facility: Research Medical Center
state: Missouri
city: Kansas City
country: United States
facility: Kansas City Cancer Center - North
state: Missouri
city: Lee's Summit
country: United States
facility: Kansas City Cancer Centers - East
state: Missouri
city: Saint Louis
country: United States
facility: St. Louis University Health Sciences Center
state: Missouri
city: Lincoln
country: United States
facility: Nebraska Cancer Research Center
state: Nebraska
city: Lincoln
country: United States
facility: St. Elizabeth Community Health Center
state: Nebraska
city: Omaha
country: United States
facility: Alegent Health Immanuel Medical Center
state: Nebraska
city: Omaha
country: United States
facility: Alegent Health Bergan Mercy Medical Center
state: Nebraska
city: Omaha
country: United States
facility: CCOP, Missouri Valley Cance Consortium
state: Nebraska
city: Omaha
country: United States
facility: Creighton University Cancer Center
state: Nebraska
city: Papillion
country: United States
facility: Alegent Health Midlands Hospital
state: Nebraska
city: Henderson
country: United States
facility: Comprehensive Cancer Centers of Nevada (Siena)
state: Nevada
city: Henderson
country: United States
facility: US Oncology West Region Office (Horizon Ridge)
state: Nevada
city: Henderson
country: United States
facility: Comprehensive Cancer Centers of Nevada (Wigwam)
state: Nevada
city: Las Vegas
country: United States
facility: Comprehensive Cancer Centers of Nevada (Peak Dr.)
state: Nevada
city: Las Vegas
country: United States
facility: Comprehensive Cancer Centers of Nevada (Southern Hills)
state: Nevada
city: Las Vegas
country: United States
facility: Comprehensive Cancer Centers of Nevada (Twain)
state: Nevada
city: Reno
country: United States
facility: Renown Regional Medical Center
state: Nevada
city: Hamilton
country: United States
facility: Cancer Institute of New Jersey at Hamilton
state: New Jersey
city: Morristown
country: United States
facility: Hematology-Oncology Associates of NNJ, PA
state: New Jersey
city: New Brunswick
country: United States
facility: Cancer Institute of New Jersey
state: New Jersey
city: Newark
country: United States
facility: Newark Beth Israel Medical Center
state: New Jersey
city: Parsippany
country: United States
facility: Saint Clare's Center at Parsippany Commons
state: New Jersey
city: Somerville
country: United States
facility: Somerset Medical Center
state: New Jersey
city: Sparta
country: United States
facility: Sparta Cancer Center
state: New Jersey
city: Las Cruces
country: United States
facility: Texas Oncology PA Las Cruces
state: New Mexico
city: Santa Fe
country: United States
facility: New Mexico Cancer Care Associates
state: New Mexico
city: Albany
country: United States
facility: New York Oncology Hematology PC-Albany
state: New York
city: Albany
country: United States
facility: New York Oncology Hematology, PC at Albany Medical Center
state: New York
city: Amsterdam
country: United States
facility: Amsterdam Community Cancer Program
state: New York
city: Brockport
country: United States
facility: Interlakes Oncology Hematology PC
state: New York
city: Canandaigua
country: United States
facility: Interlakes Oncology & Hematology, P.C.
state: New York
city: Geneva
country: United States
facility: Interlakes Oncology Hematology PC
state: New York
city: Glens Falls
country: United States
facility: Cancer Center at Glens Falls Hospital
state: New York
city: Hudson
country: United States
facility: New York Oncology Hematology, P.C. at Cavell Cancer Treatment Program
state: New York
city: Latham
country: United States
facility: New York Oncology Hematology, PC
state: New York
city: Manhasset
country: United States
facility: CCOP - North Shore University Hospital
state: New York
city: New Hyde Park
country: United States
facility: CCOP, Long Island Jewish Medical Center
state: New York
city: New York
country: United States
facility: New York University School of Medicine
state: New York
city: Rexford
country: United States
facility: New York Oncology Hematology PC
state: New York
city: Rochester
country: United States
facility: Interlakes Oncology Hematology PC - White Spruce
state: New York
city: Rochester
country: United States
facility: Interlakes Oncology Hematology PC- Long Pond
state: New York
city: Stony Brook
country: United States
facility: University Hospital and Medical Center - SUNY Stony Brook
state: New York
city: Troy
country: United States
facility: Troy Cancer Treatment Program
state: New York
city: Burlington
country: United States
facility: Alamance Regional Medical Center
state: North Carolina
city: Cary
country: United States
facility: Cancer Centers of North Carolina
state: North Carolina
city: Chapel Hill
country: United States
facility: University of North Carolina at Chapel Hill
state: North Carolina
city: Charlotte
country: United States
facility: CCOP Carolinas HealthCare System
state: North Carolina
city: Charlotte
country: United States
facility: Presbyterian Hospital
state: North Carolina
city: Durham
country: United States
facility: Regional Cancer Care, PA
state: North Carolina
city: Elizabeth City
country: United States
facility: Virginia Oncology Associates
state: North Carolina
city: Fayetteville
country: United States
facility: Cape Fear Valley Medical Center Cancer Center
state: North Carolina
city: Goldsboro
country: United States
facility: Wayne Memorial Hospital, Incorporated
state: North Carolina
city: Greensboro
country: United States
facility: CCOP, Moses Cone Health System-Regional CA Cntr
state: North Carolina
city: Greenville
country: United States
facility: East Carolina University
state: North Carolina
city: Hendersonville
country: United States
facility: Margaret R. Pardee Memorial Hospital
state: North Carolina
city: High Point
country: United States
facility: High Point Regional Hospital
state: North Carolina
city: Raleigh
country: United States
facility: Cancer Centers of North Carolina
state: North Carolina
city: Raleigh
country: United States
facility: Cancer Centers of North Carolina- North Raleigh
state: North Carolina
city: Winston-Salem
country: United States
facility: CCOP Forsyth Memorial Hospital
state: North Carolina
city: Fargo
country: United States
facility: Innovis Health
state: North Dakota
city: Akron
country: United States
facility: Akron City Hospital
state: Ohio
city: Canton
country: United States
facility: Aultman Hospital
state: Ohio
city: Cincinnati
country: United States
facility: SCRI Oncology Hematology Care, Inc. - Cincinnati (TFT)
state: Ohio
city: Cincinnati
country: United States
facility: SCRI Oncology Hematology Care, Inc - Cincinnati (AND)
state: Ohio
city: Cincinnati
country: United States
facility: SCRI Oncology Hematology Care, Inc. - Cincinnati (KWD)
state: Ohio
city: Cincinnati
country: United States
facility: SCRI Oncology Hematlogy Care, Inc. - Cincinnati (RPR)
state: Ohio
city: Cincinnati
country: United States
facility: SCRI Oncology Hematology Care, Inc - Cincinnati (BAM)
state: Ohio
city: Cincinnati
country: United States
facility: SCRI Oncology Hematology Care, Inc. Cincinnati (WST)
state: Ohio
city: Dayton
country: United States
facility: Good Samaritan Hospital
state: Ohio
city: Dayton
country: United States
facility: CCOP - Dayton
state: Ohio
city: Fairfield
country: United States
facility: HemOnc Care, Inc.
state: Ohio
city: Franklin
country: United States
facility: Atrium Medical Center - Middletown Regional Hosp
state: Ohio
city: Greenville
country: United States
facility: Wayne Hospital
state: Ohio
city: Hamilton
country: United States
facility: SCRI Oncology Hematology Care, Inc. - Hamilton (HAM)
state: Ohio
city: Kettering
country: United States
facility: Greater Dayton Cancer Center
state: Ohio
city: Kettering
country: United States
facility: Kettering Medical Center
state: Ohio
city: Troy
country: United States
facility: Upper Valley Medical Center
state: Ohio
city: Wilmington
country: United States
facility: Clinton Memorial Hospital
state: Ohio
city: Wilmington
country: United States
facility: SCRI Oncology Hematology Care, Inc. - Wilmington (WLM)
state: Ohio
city: Bend
country: United States
facility: St. Charles Medical Center - Bend
state: Oregon
city: Eugene
country: United States
facility: Willamette Valley Cancer Institute and Research Center
state: Oregon
city: Portland
country: United States
facility: Northwest Cancer Specialists-Portland
state: Oregon
city: Portland
country: United States
facility: Providence Medical Center
state: Oregon
city: Portland
country: United States
facility: Northwest Cancer Specialists- St. Vincent
state: Oregon
city: Portland
country: United States
facility: Providence St. Vincent Medical Center
state: Oregon
city: Portland
country: United States
facility: Northwest Cancer Specialists- Rose Qtr
state: Oregon
city: Springfield
country: United States
facility: Williamette Valley Cancer Institute and Research Center
state: Oregon
city: The Dalles
country: United States
facility: Celilo Center for Cancer Care
state: Oregon
city: Tualatin
country: United States
facility: Northwest Cancer Specialists-Tualatin
state: Oregon
city: Danville
country: United States
facility: Geisinger Clinic
state: Pennsylvania
city: DuBois
country: United States
facility: Oncology Hematology Associates of Northern PA
state: Pennsylvania
city: East Stroudsburg
country: United States
facility: Pocono Medical Center
state: Pennsylvania
city: Ephrata
country: United States
facility: Ephrata Community Hopital
state: Pennsylvania
city: Hazleton
country: United States
facility: Geisinger Hazleton Cancer Center
state: Pennsylvania
city: Kingston
country: United States
facility: Medical Oncology Associates
state: Pennsylvania
city: Media
country: United States
facility: Riddle Memorial Hospital
state: Pennsylvania
city: Philadelphia
country: United States
facility: Rittenhouse Hematology/Oncology
state: Pennsylvania
city: Philadelphia
country: United States
facility: Thomas Jefferson University Hospital
state: Pennsylvania
city: Philadelphia
country: United States
facility: Albert Einstein Healthcare Network
state: Pennsylvania
city: Pittsburgh
country: United States
facility: Allegheny General Hospital/Allegheny-Singer Research Institute
state: Pennsylvania
city: Pittsburgh
country: United States
facility: University of Pittsburgh
state: Pennsylvania
city: Scranton
country: United States
facility: Hematology and Oncology Associates of NEPA
state: Pennsylvania
city: Scranton
country: United States
facility: Scranton Hematology Oncology
state: Pennsylvania
city: State College
country: United States
facility: Geisinger Medical Group - Scenery Park
state: Pennsylvania
city: Upland
country: United States
facility: Associates in Hematology-Oncology, PC at Crozer Regional Cancer Center
state: Pennsylvania
city: West Reading
country: United States
facility: Reading Hospital and Medical Center
state: Pennsylvania
city: Wilkes-Barre
country: United States
facility: Geisinger Wyoming Valley Medical Center
state: Pennsylvania
city: Anderson
country: United States
facility: AnMed Health Cancer Center
state: South Carolina
city: Charleston
country: United States
facility: Roper Hosp & Med Asso (Care Alliance Health)
state: South Carolina
city: Charleston
country: United States
facility: Medical University of South Carolina
state: South Carolina
city: Columbia
country: United States
facility: SCRI - South Carolina Oncology Associates - Stoneridge
state: South Carolina
city: Easley
country: United States
facility: Cancer Centers of the Carolinas Easley, SC
state: South Carolina
city: Georgetown
country: United States
facility: Georgetown Hospital System
state: South Carolina
city: Greenville
country: United States
facility: Cancer Centers of the Carolinas (Butternut)
state: South Carolina
city: Greenville
country: United States
facility: Cancer Centers of the Carolinas-W. Faris Road
state: South Carolina
city: Greenville
country: United States
facility: Cancer Centers of the Carolinas (International)
state: South Carolina
city: Seneca
country: United States
facility: Cancer Centers of the Carolinas - Seneca
state: South Carolina
city: Spartanburg
country: United States
facility: Spartanburg Regional Healthcare System
state: South Carolina
city: Spartanburg
country: United States
facility: Cancer Centers of the Carolinas - Spartanburg
state: South Carolina
city: Sioux Falls
country: United States
facility: Avera McKenna Hospital
state: South Dakota
city: Sioux Falls
country: United States
facility: Avera Cancer Institute
state: South Dakota
city: Sioux Falls
country: United States
facility: CCOP, Sanford Cancer Center - Oncology Clinic
state: South Dakota
city: Chattanooga
country: United States
facility: SCRI Chattanooga Oncol & Hematol Assoc, PC - Chattanooga
state: Tennessee
city: Franklin
country: United States
facility: SCRI Tennessee Oncology - PLLC Franklin
state: Tennessee
city: Gallatin
country: United States
facility: SCRI Tennessee Oncology- Gallatin
state: Tennessee
city: Hermitage
country: United States
facility: SCRI Tennessee Oncology, PLLC Hermitage
state: Tennessee
city: Hixson
country: United States
facility: SCRI Chattanooga Oncol & Hematol Assoc, PC Hixson
state: Tennessee
city: Kingsport
country: United States
facility: CCOP Holston Valley Medical Center
state: Tennessee
city: Lebanon
country: United States
facility: SCRI Tennessee Oncology Lebanon
state: Tennessee
city: Murfreesboro
country: United States
facility: SCRI Tennessee Oncology Murfreesboro
state: Tennessee
city: Nashville
country: United States
facility: SCRI - Tennessee Oncology PLLC
state: Tennessee
city: Nashville
country: United States
facility: SCRI Tennessee Oncology, PLLC (Harding)
state: Tennessee
city: Nashville
country: United States
facility: SCRI Tennessee Onclogy, PLLC (Dickerson)
state: Tennessee
city: Nashville
country: United States
facility: SCRI - Tennessee Oncology PLLC
state: Tennessee
city: Nashville
country: United States
facility: SCRI Tennessee Oncology, PLLC (Wallace)
state: Tennessee
city: Shelbyville
country: United States
facility: Tennessee Oncology
state: Tennessee
city: Smyrna
country: United States
facility: SCRI Tennessee Oncology, PLLC Smyrna
state: Tennessee
city: Abilene
country: United States
facility: Texas Cancer Center - Abilene South
state: Texas
city: Amarillo
country: United States
facility: Texas Oncology PA - Amarillo
state: Texas
city: Arlington
country: United States
facility: Texas Oncology PA - Arlington North
state: Texas
city: Arlington
country: United States
facility: Texas Onclogy - Arlington South
state: Texas
city: Austin
country: United States
facility: Texas Oncology Central Austin
state: Texas
city: Austin
country: United States
facility: Texas Oncology Cancer Center - Balcones
state: Texas
city: Austin
country: United States
facility: South Austin Cancer Center
state: Texas
city: Austin
country: United States
facility: Southwest Regional Cancer Center- North
state: Texas
city: Austin
country: United States
facility: Texas Oncology North Austin- Renfert
state: Texas
city: Beaumont
country: United States
facility: Mamie McFaddin Ward Cancer Center
state: Texas
city: Bedford
country: United States
facility: Edwards Cancer Center - Bedford
state: Texas
city: Bedford
country: United States
facility: Texas Oncology PA - Harris HEB
state: Texas
city: Cedar Park
country: United States
facility: Texas Oncology, PA - Cedar Park
state: Texas
city: Dallas
country: United States
facility: Texas Cancer Center at Medical City
state: Texas
city: Dallas
country: United States
facility: Texas Oncology PA- Presbyterian
state: Texas
city: Dallas
country: United States
facility: Methodist Charlton Cancer Center
state: Texas
city: Dallas
country: United States
facility: Texas Oncology- Sammons CC
state: Texas
city: Denton
country: United States
facility: Texas Cancer Center
state: Texas
city: El Paso
country: United States
facility: El Paso Cancer Treatment Center - West
state: Texas
city: El Paso
country: United States
facility: El Paso Cancer Treatment Center - East
state: Texas
city: Fort Worth
country: United States
facility: Texas Oncology - 8th Avenue
state: Texas
city: Fort Worth
country: United States
facility: Texas Oncology at Klabzuba
state: Texas
city: Fort Worth
country: United States
facility: Texas Oncology PA - 12th Avenue
state: Texas
city: Fort Worth
country: United States
facility: Southwest Fort Worth Cancer Center
state: Texas
city: Fredericksburg
country: United States
facility: San Antonio Tumor and Blood Clinic
state: Texas
city: Garland
country: United States
facility: Texas Oncology PA
state: Texas
city: Grapevine
country: United States
facility: Texas Oncology
state: Texas
city: Houston
country: United States
facility: Texas Oncology PA - Frostwood
state: Texas
city: Houston
country: United States
facility: MD Anderson Cancer Center
state: Texas
city: Kerrville
country: United States
facility: San Antonio Tumor and Blood Clinic
state: Texas
city: Lewisville
country: United States
facility: Lake Vista Cancer Center
state: Texas
city: Longview
country: United States
facility: Longview Cancer Center
state: Texas
city: Lubbock
country: United States
facility: Joe Arrington Cancer Research & Treatment Center
state: Texas
city: McAllen
country: United States
facility: South Texas Cancer Center - McAllen
state: Texas
city: Mesquite
country: United States
facility: Texas Cancer Center of Mesquite
state: Texas
city: Midland
country: United States
facility: Allison Cancer Center
state: Texas
city: New Braunfels
country: United States
facility: HOAST - New Braunfels
state: Texas
city: Odessa
country: United States
facility: Texas Oncology - Odessa
state: Texas
city: Paris
country: United States
facility: Paris Regional Cancer Center
state: Texas
city: Plano
country: United States
facility: North Texas Regional Cancer Center
state: Texas
city: Plano
country: United States
facility: Texas Oncology Plano West Cancer Center
state: Texas
city: Round Rock
country: United States
facility: Texas Oncology Seton Williamson
state: Texas
city: Round Rock
country: United States
facility: Texas Oncology - Round Rock Cancer Center
state: Texas
city: San Antonio
country: United States
facility: Cancer Care Centers of South Texas- Brooklyn
state: Texas
city: San Antonio
country: United States
facility: Cancer Care Centers of South Texas - Loop 410
state: Texas
city: San Antonio
country: United States
facility: HOAST - Medical Drive
state: Texas
city: San Antonio
country: United States
facility: San Antonio Tumor and Blood Clinic - M.Oak
state: Texas
city: San Antonio
country: United States
facility: University of Texas Health Science Center
state: Texas
city: San Marcos
country: United States
facility: Texas Oncology - San Marcos
state: Texas
city: Sherman
country: United States
facility: Texas Cancer Center
state: Texas
city: Sugar Land
country: United States
facility: Texas Oncology Cancer Center - Sugar Land
state: Texas
city: The Woodlands
country: United States
facility: US Oncology
state: Texas
city: Tyler
country: United States
facility: Tyler Cancer Center
state: Texas
city: Waco
country: United States
facility: Texas Oncology Cancer Care and Research Center
state: Texas
city: Webster
country: United States
facility: Texas Oncology - Clear Lake
state: Texas
city: Weslaco
country: United States
facility: South Texas Cancer Clinic
state: Texas
city: Wichita Falls
country: United States
facility: Texoma Cancer Center
state: Texas
city: Cedar City
country: United States
facility: Sandra L. Maxwell Cancer Center
state: Utah
city: Ogden
country: United States
facility: McKay-Dee Hospital Center
state: Utah
city: Provo
country: United States
facility: Utah Valley Regional Medical Center - Provo
state: Utah
city: Saint George
country: United States
facility: Dixie Regional Medical Center - East Campus
state: Utah
city: Salt Lake City
country: United States
facility: Huntsman Cancer Inst. at the University of Utah- Salt Lake City
state: Utah
city: Salt Lake City
country: United States
facility: LDS Hospital
state: Utah
city: Bennington
country: United States
facility: Southwestern Regional Cancer Center (SWORD)
state: Vermont
city: Arlington
country: United States
facility: Arlington Fairfax Hematology Oncology
state: Virginia
city: Chesapeake
country: United States
facility: Virginia Oncology Associates - Medical Pkwy
state: Virginia
city: Christiansburg
country: United States
facility: Oncology and Hematology Associates of SW VA, Inc
state: Virginia
city: Fairfax
country: United States
facility: Fairfax Northern VA Hematology-Oncology PC
state: Virginia
city: Fairfax
country: United States
facility: Fair Oaks Office
state: Virginia
city: Gainesville
country: United States
facility: Fairfax-Northern Virginia Hematology-Oncology PC
state: Virginia
city: Hampton
country: United States
facility: Virginia Oncology Associates
state: Virginia
city: Leesburg
country: United States
facility: Fairfax-Northern Virginia Hematology-Oncology PC
state: Virginia
city: Mechanicsville
country: United States
facility: SCRI Virginia Cancer Institute (Flank)
state: Virginia
city: Midlothian
country: United States
facility: SCRI Virginia Cancer Institute
state: Virginia
city: Newport News
country: United States
facility: Virginia Oncology Associates
state: Virginia
city: Norfolk
country: United States
facility: Virginia Oncology Associates - Lake Wright
state: Virginia
city: Richmond
country: United States
facility: SCRI Virginia Cancer Institute (6605)
state: Virginia
city: Richmond
country: United States
facility: SCRI Virginia Cancer Institute (1401)
state: Virginia
city: Richmond
country: United States
facility: MBCCOP, Virginia Commonwealth University
state: Virginia
city: Roanoke
country: United States
facility: Oncology and Hematology Associates of SW VA, Inc
state: Virginia
city: Salem
country: United States
facility: Oncology and Hematology Associates of SW VA, Inc
state: Virginia
city: Virginia Beach
country: United States
facility: Virginia Oncology Associates
state: Virginia
city: Williamsburg
country: United States
facility: Virginia Oncology Associates
state: Virginia
city: Winchester
country: United States
facility: Fairfax Northern Virginia Hematology-Oncology - Winchester
state: Virginia
city: Woodbridge
country: United States
facility: Fairfax-Northern Virginia Hematology-Oncology PC
state: Virginia
city: Wytheville
country: United States
facility: Oncology and Hematology Associates of SW VA, Inc
state: Virginia
city: Burien
country: United States
facility: Highline Medical Oncology
state: Washington
city: Edmonds
country: United States
facility: Puget Sound Cancer Center- Edmonds
state: Washington
city: Kennewick
country: United States
facility: Columbia Basin Hematology and Oncology
state: Washington
city: Seattle
country: United States
facility: Fred Hutchinson Cancer Research Center
state: Washington
city: Seattle
country: United States
facility: Puget Sound Cancer Center - Seattle
state: Washington
city: Spokane
country: United States
facility: Cancer Care Northwest-South
state: Washington
city: Spokane
country: United States
facility: Rockwood Clinic Cancer Treatment Center
state: Washington
city: Spokane
country: United States
facility: Cancer Care Northwest-Radiation Therapy (XRT)
state: Washington
city: Spokane
country: United States
facility: Cancer Care Northwest- Valley - Mission
state: Washington
city: Spokane
country: United States
facility: Cancer Care Northwest-North - Holland
state: Washington
city: Spokane
country: United States
facility: Evergreen Hematology & Oncology (Farwell)
state: Washington
city: Vancouver
country: United States
facility: Northwest Cancer Specialists-136th Ave
state: Washington
city: Vancouver
country: United States
facility: Northwest Cancer Specialists-134th St.
state: Washington
city: Yakima
country: United States
facility: Yakima Valley Memorial Hospital - North Star Lodge
state: Washington
city: Beckley
country: United States
facility: Raleigh Regional Cancer Center
state: West Virginia
city: Charleston
country: United States
facility: CAMC Health Education & Research Institute, Inc.
state: West Virginia
city: Morgantown
country: United States
facility: West Virginia University Hospitals Inc.
state: West Virginia
city: Parkersburg
country: United States
facility: Camden-Clark Memorial Hospital
state: West Virginia
city: Wheeling
country: United States
facility: Wheeling Hospital
state: West Virginia
city: Chippewa Falls
country: United States
facility: Marshfield Clinic Chippewa Falls Center
state: Wisconsin
city: Eau Claire
country: United States
facility: Marshfield Clinic Regional CA Cntr - Sacred Heart Hospital
state: Wisconsin
city: Green Bay
country: United States
facility: CCOP, St. Vincent Hospital
state: Wisconsin
city: Green Bay
country: United States
facility: CCOP, St. Mary's Hospital Medical Center
state: Wisconsin
city: Marshfield
country: United States
facility: CCOP - Marshfield Clinic Research Foundation
state: Wisconsin
city: Milwaukee
country: United States
facility: Aurora Sinai Medical Center
state: Wisconsin
city: Milwaukee
country: United States
facility: Froedtert Hospital
state: Wisconsin
city: Milwaukee
country: United States
facility: Medical College of Wisconsin
state: Wisconsin
city: Minocqua
country: United States
facility: Marshfield Clinic Minocqua Center
state: Wisconsin
city: Oshkosh
country: United States
facility: Vince Lombardi Cancer Clinic - Oshkosh
state: Wisconsin
city: Rhinelander
country: United States
facility: Marshfield Clinic at James Beck Cancer Center
state: Wisconsin
city: Rice Lake
country: United States
facility: Marshfield Clinic Rice Lake Center
state: Wisconsin
city: Stevens Point
country: United States
facility: Marshfield Clinic Cancer Care at St. Michael's Hospital
state: Wisconsin
city: Wausau
country: United States
facility: Aspirus Regional Cancer Center
state: Wisconsin
city: West Allis
country: United States
facility: Aurora Women's Pavilion of Aurora West Allis Medical Center
state: Wisconsin
city: Weston
country: United States
facility: CCOP Marshfield Clinic - Weston Center
state: Wisconsin
city: Wisconsin Rapids
country: United States
facility: Marshfield Clinic Wisconsin Rapids Center
state: Wisconsin
city: Cork
country: Ireland
facility: Bon Secours Hospital
state: CK
city: Letterkenny
country: Ireland
facility: Letterkenny General Hospital
state: DL
city: Dublin
country: Ireland
facility: Mater Private Hospital
state: DN
city: Dublin
country: Ireland
facility: Beaumont Hospital
city: Dublin
country: Ireland
facility: St. Vincent's University Hospital
city: Dublin
country: Ireland
facility: Mater Misericordiae
city: Dublin
country: Ireland
facility: St James' Hospital
city: Dublin
country: Ireland
facility: St. James' Hospital
city: Galway
country: Ireland
facility: University College Hospital
city: Sligo
country: Ireland
facility: Sligo General Hospital
city: Waterford
country: Ireland
facility: Waterford Regional Hospital
Study officials:
affiliation: NSABP Foundation Inc
name: Norman Wolmark, MD
role: PRINCIPAL_INVESTIGATOR
References: