Clinical trial NCT03859518: Study of the Role of Innate Lymphoid Cells and Natural Killer Cells in Immune Activation of Vitiligo - INNATE Vitiligo
Official title: Study of the Role of Innate Lymphoid Cells and Natural Killer Cells in Immune Activation of Vitiligo
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Vitiligo
Lead sponsor: Centre Hospitalier Universitaire de Nice
Sponsor class: OTHER
Collaborators: name: Institut National de la Santé Et de la Recherche Médicale, France
First posted: 2019-03-01
Enrollment: 20
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: in this study, there are 2 groups. First with vitiligo and the second only with control subjects without autoimmune or inflammatory diseases.

All this subjects were include in the dermatolgy servive of the CHU of Nice.

Brief summary: The cohort included only major patients with non-segmental vitiligo and no other autoimmune or inflammatory associated diseases (except thyroiditis). Control subjects should have no autoimmune or inflammatory diseases. Patients and controls should not take treatment with corticosteroids or other potentially immunomodulatory therapies. Patients and controls are recruited in the Dermatology Department of the University Hospital of Nice and the Hospital of Fréjus. The investigators have already initiated the collection of tissues and blood from patients and control subjects and we have succeeded in isolating ILCs and NKs from a blood volume of 50ml. We were able to sort the ILC subpopulations. Early data suggest an increase in Natural Killer (NK) and Innate Lymphoïdes Cells 1 (ILC1) in the blood of vitiligo patients compared to control subjects. The investigators also managed to extract the melanocytes from the skin biopsies of the first patients and control subjects.

Detailed description: The investigators want study the presence and type of ILC and NK in the blood and skin of vitiligo patients compared to control subjects.

Eligibility criteria: Inclusion Criteria:

vitiligo subjects :

* patients in the cohort with non-segmental vitiligo
* without other autoimmune or inflammatory diseases associated

control subjects :

* subject without autoimmune or inflammatory disease

Primary outcomes:
measure: study the presence and type of ILC and NK in the blood and skin
timeFrame: 1 day
measure: study the presence and type of ILC and NK in the skin
timeFrame: 1 day
Secondary outcomes:
Other outcomes:
Locations:
city: Fréjus
country: France
facility: CH de Frejus
Study officials:
affiliation: Centre Hospitalier Universitaire de Nice
name: Thierry PASSERON, MD; PhD
role: PRINCIPAL_INVESTIGATOR
References:
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