Clinical trial NCT00960609: Communicating Veins Between Adjacent Hepatic Veins: an Intra-operative Ultrasound Study
Official title: Communicating Veins Between Adjacent Hepatic Veins: Rare, Exceptional or Frequent? An Intra-operative Ultrasound Study
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Liver Tumors
Keywords: Communicating veins
hepatic venous anastomosis
intra-operative ultrasonography
hepatic resection
hepatic neoplasm
Primary and metastatic liver tumors
Lead sponsor: University of Milan
Sponsor class: OTHER
First posted: 2009-08-18
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: Patients with primary and metastatic liver tumors addressed to surgical treatment

Brief summary: The search for communicating veins (CVs) between adjacent hepatic veins (HVs) has drawn its rationale from living donor liver transplantation (LDLT). Parenchymal sparing procedures although HVs are resected suggest that probably their presence is underestimated.

Taking profit from new improvements in ultrasound technology the investigators aim to better estimate the rate of CVs in a consecutive series of patients in whom resection of one HV at caval confluence is needed.

Detailed description: The search for communicating veins (CVs) between adjacent hepatic veins (HVs) has drawn its rationale from the need of reducing the risk of incomplete blood outflow in the medial portion of the hemiliver without the middle hepatic vein (MHV) in living donor liver transplantation (LDLT). However, only 24% of patients seems having CVs based on the findings of color-Doppler intraoperative ultrasound (CD-IOUS) exploration. On the other hand the safety of parenchymal sparing procedure despite HV resection let suppose that CVs are probably more frequent than expected.

Certainly, better in vivo knowledge of the rate of CVs and their direct detection would consolidate and probably further expand parenchymal sparing techniques. Taking profit from new advancements in ultrasound technology we have carried out the present study with the aim of better estimating the rate of CVs in a consecutive series of patients in whom resection of one HV at caval confluence was needed.

Eligibility criteria: Inclusion Criteria:

* Patients suitable for being enrolled in the present study were those carriers of primary or metastatic tumour with direct contact or invasion of one HV at the caval confluence.

Exclusion Criteria:

* N/A

Primary outcomes:
measure: First outcome was the rate of CVs detectable with e-flow IOUS along clamping of the HV for which resection could be needed.
Secondary outcomes:
measure: Secondary outcome was safety (morbidity, mortality, blood loss, blood transfusions) of the procedure.
Other outcomes:
Locations:
city: Rozzano
country: Italy
facility: Istituto Clinico Humanitas, IRCCS
state: Milano
Study officials:
References:
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