Clinical trial NCT04828642: Antioxidant Vitaminas and Hypertrophy Adaptations to Resistance Training
Official title: Vitamins C and Vitamin E and Hypertrophy Adaptations to Resistance Traini
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Hypertrophy
Lead sponsor: Universidad Europea de Madrid
Sponsor class: OTHER
First posted: 2021-04-02
Enrollment: 30
Sex: MALE
Minimum age (years): 18
Maximum age (years): 30
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Intervention model description: A randomized, double-blind, placebo-control, parallel controlled trial will be conducted.
Primary purpose: BASIC_SCIENCE

Brief summary: This investigations aims to investigate whether supplementation with antioxidant vitamins (vitamin C and vitamin E) can influence, enhancing or blocking, the hypertrophic adaptations caused by strength training in sedentary subjects.

Detailed description: A randomized, double-blind, placebo-control controlled trial will be conducted. In a previous session volunteers will be interviewed to determine if they meet the inclusion criteria. Will be done two weeks of flushing out other types of supplementation and strenuous physical exercise, along with familiarization with the strength training program and performance tests to be carried out during the rehearsal. Subsequently, it will be a week without exercising to start with the experimental designs. From the start of the trial, participants should avoid physical exercise. strenuous outside the training protocol and if usual, they will only be able to perform one resistance training session per week. Participants should avoid ingesting of foods that contain high amounts of antioxidant compounds: more than two juices of fruits, more than four cups of coffee or tea. Juices with high antioxidant content should be avoided. Alcoholic beverages should also be avoided.

* Group 1 (G1): Antioxidant vitamins (VitC (1000 mg) + VitE (235 mg)) + exercise
* Group 2 (G2): Placebo + exercise A supplementation period of 12 weeks will be carried out. In each period, supplementation with antioxidant vitamins: VitC (1000 mg) + VitE (235 mg) or with placebo.

All participants will ingest the supplementation between 1-3 hours before training, the days of rest in the mornings.

All participants will perform a 12-week strength training protocol. The training session performed in the sharp design will be the first training session in chronic design. Being the baseline (E0) and post-exercise (E1) assessment performed in G1, G2 and G3 also the first evaluation corresponding to the chronic design.

In the middle of the supplementation period (week 6) and at the end, two new evaluations (week 12). Baseline evaluations will be performed prior to an exercise session of week 6 (E2) and at the last exercise session (E3) of the following parameters: performance physique, body composition, micronutrient analysis, muscle ultrasound. I also know conduct post-exercise physical performance assessments Figure 2.

The strength training protocol will be carried out 4 days a week at the facilities sports of the European University. The sessions will be planned by a professional from the Sciences of Physical Activity and Sports. Sessions will be tracked through a diary.

Eligibility criteria: Inclusion Criteria:

* Experience in strength training of at least one year

Exclusion Criteria:

* Smokers
* Antioxidant supplementation
* Injuries or diseases

Primary outcomes:
measure: DEXA
timeFrame: Week 0
measure: DEXA
timeFrame: Week 10
measure: Anthropometry
timeFrame: Week 0
measure: Anthropometry
timeFrame: Week 5
measure: Anthropometry
timeFrame: Week 10
measure: Bioimpedance
timeFrame: Week 0
measure: Bioimpedance
timeFrame: Week 5
measure: Bioimpedance
timeFrame: Week10
measure: DOMS
timeFrame: Week 0
measure: DOMS
timeFrame: Week 5
measure: DOMS
timeFrame: Week 10
measure: Manual dinamometry
timeFrame: Week 0
measure: Manual dinamometry
timeFrame: Week 5
measure: Leg dinamometry
timeFrame: Week 0
measure: Leg dinamometry
timeFrame: Week 5
measure: Leg dinamometry
timeFrame: Week 10
measure: RPE
timeFrame: Week 0
measure: RPE
timeFrame: Week 5
measure: RPE
timeFrame: Week 10
measure: 1 RM
timeFrame: Week 0
measure: 1 RM
timeFrame: Week 5
measure: 1 RM
timeFrame: Week 10
measure: Parameters determined by ENCODER
timeFrame: Week 0
measure: Parameters determined by ENCODER
timeFrame: Week 5
measure: Parameters determined by ENCODER
timeFrame: Week 10
Secondary outcomes:
Other outcomes:
Locations:
city: Madrid
country: Spain
facility: Universidad Europea de Madrid
Study officials:
References:
citation: Dutra MT, Martins WR, Ribeiro ALA, Bottaro M. The Effects of Strength Training Combined with Vitamin C and E Supplementation on Skeletal Muscle Mass and Strength: A Systematic Review and Meta-Analysis. J Sports Med (Hindawi Publ Corp). 2020 Jan 8;2020:3505209. doi: 10.1155/2020/3505209. eCollection 2020.
citation: Dutra MT, Alex S, Mota MR, Sales NB, Brown LE, Bottaro M. Effect of strength training combined with antioxidant supplementation on muscular performance. Appl Physiol Nutr Metab. 2018 Aug;43(8):775-781. doi: 10.1139/apnm-2017-0866. Epub 2018 Jun 25.