louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT01434433: Alere Triage fs B-type Natriuretic Peptide (BNP) Method Comparison Evaluation
Official title: Alere Triage fs BNP Method Comparison Evaluation
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Specimens With BNP Values of 5 to 5000 pg/ml
Triage
Lead sponsor: Abbott RDx Cardiometabolic
Sponsor class: OTHER
First posted: 2011-09-15
Enrollment: 360
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: RETROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Emergency Department, Hospital

Brief summary: This study will evaluate method correlation and mean bias between six B-type natriuretic peptide (BNP) platforms.


Eligibility criteria: Inclusion Criteria:

* Samples with BNP range of 5-5000 pg/ml
* Samples with sufficient volume for testing

Exclusion Criteria:

* BNP \<5 pg/ml

Primary outcomes:
measure: bias
timeFrame: Sept 2011
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
affiliation: Hennepin Healthcare Research Institute
name: Fred Apple, M.D.
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT01794533: Effect of Fentanyl on the Rate of Anesthesia
Official title: Analgesic Efficacy of a Combination of Fentanyl and Lidocaine for Maxillary Infiltration in Teeth With Irreversible Pulpitis
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE2
Conditions: Painful Irreversible Pulpitis
Keywords: Irreversible Pulpitis
Infiltration injection
Fentanyl
Lidocaine
Lead sponsor: Islamic Azad University, Sanandaj
Sponsor class: OTHER
First posted: 2013-02-20
Enrollment: 64
Sex: ALL
Minimum age (years): 18
Maximum age (years): 56
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: PREVENTION

Brief summary: Achievement of a deep and long-durated anesthesia is vital before most endodontic procedures; therefore, the investigators conducted this study to compare the local infiltration effect of epinephrine-containing lidocaine with/ without fentanyl on depth and duration of anesthesia in maxillary molars with painful irreversible pulpitis.

Detailed description: This study was planned with a randomized double-blind, parallel design clinical trial on 64 healthy patients after taking into account some inclusion and exclusion criteria. The control group were received the mixture of normal saline and 2% lidocaine with 1:200,000 epinephrine and the experimental group were received the mixture of fentanyl and 2% lidocaine with 1:200,000 epinephrine. The depth and duration of pulpal anesthesia were evaluated with an electric pulp testing in 5-minute intervals during a period of 60 minutes and the pain intensity recorded in five times, before injection, after injection, during access cavity preparation, pulpotomy and pulpectomy using visual analog scale(VAS). All data were analyzed and compared using chi-squared and Mann-Whitney tests.

Eligibility criteria: Inclusion Criteria:

* Patients were aged between 18 and 65 years with no systemic diseases categorized in the Class I ASA;
* Individuals requiring urgent root canal treatment of maxillary first or second molars;
* Hot painful teeth with irreversible pulpitis (moderate to severe spontaneous pain), with a positive response to thermal vitality tests (a long painful response to a cold test) and no clinical or radiographic signs or symptoms of acute or chronic apical periodontitis; and
* No history of taking analgesics in the previous 12 h.

Exclusion Criteria:

* Systemic conditions;
* Allergic reactions to opioids, benzodiazepines, barbiturates;
* Pregnancy and lactation; Contraindication of the use of epinephrine (such as unstable angina);
* Nonvital pulp after access cavity preparation

Primary outcomes:
measure: Change from Baseline in depth of anesthesia
timeFrame: Change from Baseline up to 17 minutes
Secondary outcomes:
measure: change from baseline in intensity of the pain
timeFrame: Change from Baseline up to 60 minutes
Other outcomes:
Locations:
city: Tehran
country: Iran, Islamic Republic of
facility: Islamic Azad University
Study officials:
References:
Clinical trial NCT02340533: Histopathological Diagnosis of Adenomyosis
Official title: The Diagnostic Accuracy of Hysteroscopic Endomyometrial Biopsy in Adenomyosis
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Adenomyosis
Keywords: adenomyosis
Lead sponsor: Woman's Health University Hospital, Egypt
Sponsor class: OTHER
First posted: 2015-01-16
Enrollment: 200
Sex: FEMALE
Minimum age (years): 38
Maximum age (years): 52
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: DIAGNOSTIC

Brief summary: The purpose of this study is to develop and evaluate a hysteroscopic endo-myometrial biopsy for diagnosing adenomyosis.


Eligibility criteria: Inclusion Criteria:

* females complaining of pelvic congestion: dysmenorrhea, dyspareunia, chronic pelvic pain, menorrhagia, metrorrhagia

Exclusion Criteria:

* refusal of the patient to get enrolled in the study

Primary outcomes:
measure: Number of participants with diagnosis of adenomyosis cases
timeFrame: 6 months
Secondary outcomes:
Other outcomes:
Locations:
city: Cairo
country: Egypt
facility: Kasr el aini hospital
Study officials:
affiliation: Cairo University
name: Dina M Dakhly, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT06638333: Prevalence and Serotype Distribution of Streptococcus Pneumoniae in Healthy Vietnamese Children From 6 Months to 5 Years Old
Official title: Prevalence and Serotype Distribution of Streptococcus Pneumoniae in Healthy Vietnamese Children From 6 Months to 5 Years Old
Study type: OBSERVATIONAL
Overall status: ACTIVE_NOT_RECRUITING
Conditions: Streptococcus Pneumonia
Lead sponsor: Tam Anh Research Institute
Sponsor class: OTHER
Collaborators: name: Pfizer
First posted: 2024-10-15
Enrollment: 800
Sex: ALL
Minimum age (years): 6
Maximum age (years): 5
Standard ages: CHILD
Accepts healthy volunteers: yes
Observational model: ECOLOGIC_OR_COMMUNITY
Time perspective: CROSS_SECTIONAL
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Children from 6 months and 5 years old who visit the Vietnam Vaccination Center (VNVC) system in Hanoi, Danang and Ho Chi Minh city for vaccination services

Brief summary: This observational study is designed as a cross-sectional survey of children from 6 months and 5 years old who visit the Vietnam Vaccination Center (VNVC) system in Hanoi, Danang and Ho Chi Minh City for vaccination services.

After getting the informed consent form from a parent/guardian for their child(s) to participate in the study, nasopharyngeal swab sample will be taken. His/her guardian will be interviewed face-to-face with information related to epidemiological characteristics, nutritional status, child's birth history, hospitalization history, vaccination history, recent antibiotic usage, breastfeeding time, and environmental and lifestyle factors.

The goal is to document the burden and risk factors of pneumococcal infections in the community of healthy Vietnamese children. The main questions it aims to answer are:

* What is the prevalence of pneumococcus in healthy children?
* What is the distribution of pneumococcus serotypes in the community of healthy Vietnamese children?
* What are risk factors of pneumococcus infection in the community of healthy Vietnamese children?


Eligibility criteria: Inclusion Criteria:

* Children between 6 months and 5 years

Exclusion Criteria:

* Children with chronic diseases (including immunologic diseases, neoplastic disorders, renal, cardiac, hepatic, or hematologic diseases, broncho dysplasia, Down syndrome, chronic otitis media with effusion)
* Children with acute/chronic upper or lower respiratory tract infection
* Children have used antibiotics within 1 week prior to entering the study

Primary outcomes:
measure: Prevalence of pneumococcal carriage in the nasopharynx in children from 6 months to 5 years old in the Vietnamese community
timeFrame: Day 0 after recruitment
measure: Serotype distribution of pneumococcal strains in Vietnamese children from 6 months to 5 years old in the community
timeFrame: Day 0 after recruitment
Secondary outcomes:
measure: Risk factors associated with pneumococcal carriage
timeFrame: Day 0 after recruitment
Other outcomes:
Locations:
city: Da Nang
country: Vietnam
facility: VNVC Da Nang
city: Hanoi
country: Vietnam
facility: VNVC Icon4 Cau Giay
city: Ho Chi Minh City
country: Vietnam
facility: VNVC Tan Phu
Study officials:
References:
Clinical trial NCT03765333: GETNE Registration of Thyroid Cancer
Official title: Descriptive Observational Epidemiological Study on the Characteristics of Thyroid Cancer in Patients Treated in Oncology Services of Spanish Centers: National Registry of Thyroid Cancer - Differentiated, Medullary and Anaplastic
Study type: OBSERVATIONAL
Overall status: RECRUITING
Conditions: Thyroid Cancer
Lead sponsor: Grupo Espanol de Tumores Neuroendocrinos
Sponsor class: OTHER
First posted: 2018-12-05
Enrollment: 20
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: ECOLOGIC_OR_COMMUNITY
Time perspective: CROSS_SECTIONAL
Sampling method: PROBABILITY_SAMPLE
Study population: Patients ≥ 18 years visited in the oncology services of the participating centers that have a diagnosis of primary cancer located in the thyroid gland.

Brief summary: An epidemiological, observational, multicenter, cross-sectional, retrospective study on patients ≥ 18 years visited in the oncology services of the participating centers with diagnosis of primary thyroid cancer.


Eligibility criteria: Inclusion Criteria:

* Patients older than 18 years with diagnosis of differentiated, medullary or anaplastic thyroid cancer confirmed by histopathology.
* Patients who agree to participate and are able to understand the information sheet and sign the informed consent

Exclusion Criteria:

* Patients under 18 years of age.
* Patients with other types of thyroid cancer or whose histopathological diagnosis has not been confirmed.
* Patients who do not have the relevant basic information to be included in the study, according to the criteria of the principal investigator.

Primary outcomes:
measure: Hystopathological characteristics of the tumor
timeFrame: Baseline
measure: Situation of the tumor at first-diagnosis
timeFrame: Baseline
measure: Tumor-Node-Metastasis classification
timeFrame: Baseline
measure: Tumor Stage
timeFrame: Baseline
Secondary outcomes:
measure: Patient situation at the end of treatment
timeFrame: 12 months
measure: Number of patients with BRAF mutation
timeFrame: 12 months
measure: Number of patients with RET mutation
timeFrame: 12 months
measure: Number of patients with PI3K mutation
timeFrame: 12 months
measure: Number of patients with RAS mutation
timeFrame: 12 months
measure: Number of patients with PAX8/PAR mutation
timeFrame: 12 months
measure: Number of patients with P53 mutation
timeFrame: 12 months
measure: Number of patients with PTEN mutation
timeFrame: 12 months
Other outcomes:
Locations:
city: Barcelona
country: Spain
facility: Hospital Universitari Vall d'Hebron
Study officials:
affiliation: Hospital Universitari Vall d'Hebron, Barcelona
name: Jorge Hernando Cubero, M.D.
role: STUDY_DIRECTOR
affiliation: Hospital Universitari Vall d'Hebron, Barcelona
name: Jaume Capdevila, M.D.
role: STUDY_CHAIR
References:
Clinical trial NCT00775333: Nerve Entrapment in Diabetic Patients
Official title: Clinical Outcomes of Surgical Release Among Diabetic Patients With Carpal Tunnel Syndrome. A Prospective Study With Matched Controls
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Carpal Tunnel Syndrome
Entrapment Neuropathies
Nerve Compression Syndromes
Diabetes Complications
Keywords: Carpal Tunnel Syndrome
Diabetes
APB strength
Sensory Function
Pillar Pain
Cold Intolerance
Patient Satisfaction
Lead sponsor: Skane University Hospital
Sponsor class: OTHER
First posted: 2008-10-20
Enrollment: 67
Sex: ALL
Minimum age (years): 18
Maximum age (years): 80
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: CASE_CONTROL
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Patients referred to a specialized hand clinic

Brief summary: The aim of this study is in a prospective, consecutive series of diabetic patients with carpal tunnel syndrome, who are then age and gender matched with non-diabetic patients having idiopathic carpal tunnel syndrome to compare the clinical results after carpal tunnel release.


Eligibility criteria: Inclusion Criteria:

* Diagnosis was based on clinical history and symptoms of carpal tunnel syndrome
* Confirmed by nerve conduction studies.

Exclusion Criteria:

* Other focal nerve entrapments
* Cervical radiculopathy
* Inflammatory joint disease
* Renal failure
* Thyroid disorders
* Previous wrist fracture
* Long-term exposure to vibrating tools.

Primary outcomes:
measure: Sensory function (Semmens-Weinstein), motor function (Abductor Pollicis Brevis (APB)-strength, grip strength)
timeFrame: Baseline, 6 weeks, 12 weeks, 52 weeks
Secondary outcomes:
measure: Pillar pain, cold intolerance, and patient satisfaction.
timeFrame: Baseline, 6 weeks, 12 weeks, 52 weeks
Other outcomes:
Locations:
city: Malmo
country: Sweden
facility: Dept. of Hand Surgery, Malmo University Hospital
Study officials:
name: Lars Dahlin, PHD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT02493933: Phytoestrogen, NO Donors, N-acetyl Cysteine Add Therapy to Clomiphene Citrate to Improve Pregnancy Rate in PCO Patients
Official title: Phytoestrogen, NO Donors, N-acetyl Cysteine Add Therapy to Clomiphene
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: PHASE1
Conditions: Infertility
Lead sponsor: Kasr El Aini Hospital
Sponsor class: OTHER
First posted: 2015-07-10
Enrollment: 240
Sex: FEMALE
Minimum age (years): 20
Maximum age (years): 40
Standard ages: ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: To evaluate the effect of oral Phytoestrogen or Isosorbid mononitrate or N-acetyl cysteine as an adjuvant to clomiphene citrate on induction of ovulation and pregnancy outcomes in patients with PCOS. In this three-arm open RCT, 240 PCOS infertile women were randomly divided to 3 groups for induction of ovulation. Group A, \[PE group, n= 80\] patients received CC 100mg/d plus oral Phytoestrogen120 mg/ day and patients in Group B, \[ISMN group, n=80\] received CC 100 mg/d plus 20 mg Isosorbid mononitrate and Group C, \[NAC group, n=80\] patients received CC 100 mg/d plus NAC 1200 mg/day.


Eligibility criteria: Inclusion Criteria:

1. All patients have PCOS.
2. All patients received CC 100 mg/day for 5 days starting from day 5 with successful ovulation as documented by folliculometry and midluteal serum progesterone with no pregnancy achieved.
3. All patients have patent fallopian tubes by Hysterosalpingography.
4. Their husbands have normal semen analysis according to the modified criteria of WHO.
5. All patients have normal serum prolactin and thyroid profile.
6. Any patient having vaginitis was treated before starting induction.

Exclusion Criteria:

1. Other causes of infertility than anovulation.
2. Diabetes or other endocrinological disorders.
3. Age \> 40 years.
4. Smoking.
5. Alcohol use.
6. Presence of ovarian cyst \>2cm on the second day of the cycle.
7. Patients who have received gonadotrophins in the preceeding 6 months.
8. Patients who have done unilateral or bilateral ovarian drilling.
9. Allergy to PE, NO donors or NAC

Primary outcomes:
measure: clinical pregnancy rate
timeFrame: 6 months
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
References:
Clinical trial NCT01572233: Effects of Activity and Education Program on Patients With Chronic Hepatitis C Infection
Official title: Effects of Personalized Physical Activity and Psycho-Education Program on Patients With Chronic Hepatitis C Infection
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Hepatitis C Virus Infection, Response to Therapy of
Keywords: Fatigue,Physical Activity,Hepatitis C Virus Infection
Lead sponsor: National Taiwan University Hospital
Sponsor class: OTHER
Collaborators: name: National Health Research Institutes, Taiwan
First posted: 2012-04-06
Enrollment: 300
Sex: ALL
Minimum age (years): 20
Maximum age (years): 70
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: SUPPORTIVE_CARE

Brief summary: This 4-year project will be guided by a biobehavioral model for the study of exercise interventions in two phases with the purposes to :

1. explore the patients' physical activity preferences and develop doable activity lists during treatment period
2. examine the changes of health-related physical fitness component over interferon treatment
3. develop the Personalized Physical Activity and Psych-Education (PPAPE) Program and test its effects on decreasing fatigue, physical and psychological distress, and improving their health-related physical fitness and quality of life in patients with chronic hepatitis C receiving Interferon with Ribavirin Combination Therapy
4. evaluate the outcome of the PPAPE program on increasing adherence to therapy, the sustained virological response (SVR) in 24 weeks after the end of treatment, and the time-consuming for education program during intervention.


Eligibility criteria: Inclusion Criteria:

* Patients with Chronic Hepatitis C Infection Receiving Interferon Therapy
* Aged above 18

Exclusion Criteria:

* None

Primary outcomes:
measure: Effects of Activity and Education Program on Patients with Chronic Hepatitis C Infection
timeFrame: 4-year project
Secondary outcomes:
Other outcomes:
Locations:
city: Taipei
country: Taiwan
facility: National Taiwan University Hospital
Study officials:
affiliation: National Taiwan University
name: Shiow-ching Shun, PhD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT03905733: The Effects of High-flow Nasal Oxygen on Oxygenation During Rigid Bronchoscopy Under General Anesthesia in Pediatric Patients
Official title: The Effects of High-flow Nasal Oxygen on Oxygenation During Rigid Bronchoscopy Under General Anesthesia in Pediatric Patients: A Prospective Observational Pilot Study
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Foreign Bodies
Tumor
Stenosis of Trachea
Bronchus
Lead sponsor: Yonsei University
Sponsor class: OTHER
First posted: 2019-04-05
Enrollment: 20
Sex: ALL
Maximum age (years): 7
Standard ages: CHILD
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Patients 7 years or younger who undergo general anesthesia with rigid bronchoscopy

Brief summary: The aim of this study is to evaluate the effect of high-flow nasal cannula oxygen administration on maintenance of oxygenation and removal of carbon dioxide during apnoeic period in pediatric patients undergoing general anesthesia with rigid bronchoscopy


Eligibility criteria: Inclusion Criteria:

* 1. Patients undergoing general anesthesia with stent placement or bougination, biopsy or removal of a foreign body or a mass through a rigid bronchoscope
* 2. Patients aged 7 or younger who meet American Society of Anesthesiologists (ASA) physical class 2-4

Exclusion Criteria:

* 1. Patients undergoing extracorporeal membrane oxygenation (ECMO)
* 2. Patients with active nasal bleeding), severe nasal obstruction, recent nasal trauma of surgery
* 3. Patients with current maxillofacial trauma or basal skull fracture
* 4. Patients with active nasal bleeding), severe nasal obstruction, recent nasal trauma of surgery
* 5. Extremely low birth weight infant and premature infant less than 28 weeks gestation age
* 6. Patients who had previously undergone rigid bronchoscopy / surgery
* 7. If the parent of subject includes a person who can not read the written consent (eg, illiterate, foreigner, etc.)

Primary outcomes:
measure: Hypoxia occurs the first time
timeFrame: The time taken to reach the point at which peripheral oxygen saturation fell below 90% for the first time immediately after the onset of apnea intraoperatively.
measure: the lowest oxygen saturation
timeFrame: apnea period during the rigidbroscopic procedure/surgery
measure: Occurence of hypoxic event
timeFrame: apnea period during the rigidbroscopic procedure/surgery
Secondary outcomes:
measure: End-tidal carbon dioxide partial pressure
timeFrame: end-tidal CO2 partial pressure after 3 consecutive breaths after intubation or insertion of laryngeal mask following end of apnea during intraoperative period.
measure: Arterial oxygen / carbon dioxide partial pressure
timeFrame: shortly before start of apnea (within 30 seconds) and shortly after end of apnea (within 30 seconds)
Other outcomes:
Locations:
city: Seoul
country: Korea, Republic of
facility: Department of Thoracic and Cardiovascular Surgery, Yonsei University College of Medicine
Study officials:
References:
Clinical trial NCT06595433: Effect of Post-Activation Potentiation
Official title: Effect of Post-Activation Potentiation Effect on Snatch Performance to Exhaustion in Elite Weightlifters
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Post-Activation Potentiation
Performance
Keywords: Weightlifting, snatch, training
Lead sponsor: University of Gaziantep
Sponsor class: OTHER
First posted: 2024-09-19
Enrollment: 12
Sex: MALE
Minimum age (years): 18
Maximum age (years): 21
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: SEQUENTIAL
Intervention model description: The study was designed according to a randomized crossover experimental design. All study sessions were conducted in the fitness center in the weightlifting hall.
Primary purpose: OTHER

Brief summary: This study investigated the acute effect of post-activation performance enhancement (PAPE) on snatch performance to exhaustion in elite weightlifters.

Detailed description: Background This study investigated the acute effect of post-activation performance enhancement (PAPE) on snatch performance to exhaustion in elite weightlifters.

Methods The study was designed according to a randomized crossover experimental design. Twelve male elite athletes (age; 18.45 ± 0.52 years; height; 1.73 ± 0.03m, body mass; 71.36 ± 11.36kg) voluntarily participated in the study. The participants performed a general warm-up for five minutes, followed by a weightlifting-specific warm-up for five minutes, and rested for two minutes. Then, the athletes performed three different PAPE protocols on different days and performed the snatch performance to exhaustion. Shapiro-Wilk test was applied for the normality test, and the Levene test was applied for the homogeneity test. Repeated measures of two-way analysis of variance (2x3) were applied to analyze the differences between treatments. Greenhouse-Geiser correction test was used for measurements where the sphericity assumption was not met.

Eligibility criteria: Inclusion Criteria:

* no recent injury
* no medication or supplements
* being a volunteer

Exclusion Criteria:

* doping or chronic drug use
* neuromuscular disease, metabolic, hormonal, or cardiovascular disorders,
* and orthopedic limitation

Primary outcomes:
measure: number of snatch repetitions performed to exhaustion
timeFrame: Two weeks
Secondary outcomes:
Other outcomes:
Locations:
city: Gaziantep
country: Turkey
facility: Gaziantep University, Faculty of Sport Sciences
state: Sehitkamil
Study officials:
affiliation: Sports Sciences Research Center
name: Zarife Pancar, PhD
role: STUDY_DIRECTOR
References: