Clinical trial NCT06366399: The Acute T-Rex (Timing of Resistance Exercise) Study
Official title: Timing (AM v PM) of Acute Resistance Exercise on Glycemic Control in Older Adults: The Acute T-Rex Study
Study type: INTERVENTIONAL
Overall status: RECRUITING
Phase: NA
Conditions: Diabetes Mellitus, Type 2
Insulin Resistance
Glucose Intolerance
Sleep Disturbance
Overweight or Obesity
Insulin Sensitivity
Keywords: Resistance Exercise
Strength-training
Sleep
Circadian Rhythm
Lead sponsor: University of Utah
Sponsor class: OTHER
First posted: 2024-04-15
Enrollment: 20
Sex: ALL
Minimum age (years): 50
Maximum age (years): 74
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: CROSSOVER
Primary purpose: PREVENTION

Brief summary: The primary aim of this study is to evaluate if a single bout of AM vs PM resistance exercise has different effects on insulin sensitivity and sleep. A randomized cross-over trial be used to compare resistance exercise at two different times of the day. Each condition will take place in a laboratory setting. Each condition will consist of exercise, overnight sleep, and oral glucose tolerance tests the following day. The AM exercise will occur \~1.5 hours after habitual wake, and PM exercise will occur \~11 hours after habitual wake. After a 2-6 week washout, participants will complete the other condition. The hypothesis is that PM exercise will be more beneficial than AM exercise in improving insulin sensitivity. This study could identify if there is a better time of day to perform resistance exercise to decrease risk of developing Type 2 Diabetes Mellitus.


Eligibility criteria: Inclusion Criteria:

* Men and women, all ethnicities, aged 50-74 years
* BMI ≥25 kg/m² and \<45 kg/m²
* Weight stable (less than 5% change in the past 6 months)
* Generally healthy individuals
* Not meeting recommended activity guidelines for aerobic or resistance exercise

Exclusion Criteria:

* Uncontrolled cardiovascular, metabolic, renal, or pulmonary disease
* Cancer treatment in the past 5 years
* Untreated thyroid disease or other medical conditions affecting weight or energy metabolism
* Current use of weight loss medication or other medications likely to impact energy balance
* Bariatric surgery or extensive bowel resection in the past 2 years
* Current or recent history (past 2 years) of eating disorder
* Diagnosis of insomnia, sleep apnea, or other sleep and circadian disorders
* Non-English speaking
* HbA1c \>6.5%

Primary outcomes:
measure: Insulin sensitivity
timeFrame: 1 day
Secondary outcomes:
measure: Sleep Duration
timeFrame: 1 day
Other outcomes:
measure: Sleep Staging
timeFrame: 1 day
measure: Sleep Quality
timeFrame: 1 day
measure: Sleep Efficiency
timeFrame: 1 day
measure: Muscular Strength
timeFrame: 1 day
measure: Perceived Hunger
timeFrame: 1 day
measure: Perceived Fullness
timeFrame: 1 day
measure: Perceived Prospective Food Consumption
timeFrame: 1 day
measure: Glucose Area Under Curve
timeFrame: 1 day
measure: Insulin Area Under Curve
timeFrame: 1 day
Locations:
city: Salt Lake City
country: United States
facility: University of Utah HPER E Buildling
state: Utah
Study officials:
References: