louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT06573333: Effects of Timing of Cord Clamping on Serum Calcium Levels in Neonates
Official title: Effects of Timing of Cord Clamping on Serum Calcium Levels in Neonates
Study type: INTERVENTIONAL
Overall status: RECRUITING
Phase: NA
Conditions: Serum Calcium Concentration
Lead sponsor: College of Physicians and Surgeons Pakistan
Sponsor class: OTHER
First posted: 2024-08-27
Enrollment: 200
Sex: ALL
Minimum age (years): 1
Maximum age (years): 6
Standard ages: CHILD
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Intervention model description: Randomised Controlled Trails
Primary purpose: PREVENTION

Brief summary: Title: Effect of timing of cord clamping of serum calcium levels in neonates Background: Hypocalcemia is a common metabolic problem in neonatal period. Most cases of hypocalcemia are asymptomatic however, the symptomatic cases require prompt management.

Objective: The objective is to determine the effects of early and delayed cord on serum calcium level in neonates Study Design: Randomized Controlled Trial

Detailed description: Place and Duration of Study: PEMH Rawalpindi and CMH Rawalpindi from January 2024 to July 2024.

Patients and Methods: Total sample size of 200 neonates will be included in the study divided into four groups with cord clamping at 15s, 30s, 60s, 120s each group will have a total of 50 neonates. Blood sampling for CBC / CRP / S. Electrolytes (Na, K, Total Ca, Ionized Ca, Mg), S Calcitonin, ABGs (HCO3 Levels) samples will be collected at 6 hours of life.

* Inclusion Criteria: Neonates born at gestational age 37 weeks to 41 weeks with no maternal complication. Parents who give consent for inclusion in the study
* Exclusion Criteria: Mothers with evidence of clinical disease (diabetes, preeclampsia, hypertension). Babies with congenital malformations and intrauterine growth restriction.

Expected Results: Research data on serum Calcium levels in neonates have shown no correlation to timing of cord clamping. Same results are expected in this study.

Eligibility criteria: Inclusion Criteria:

* Neonates born at gestational age 37 weeks to 41 weeks with no maternal complication. Parents who give consent for inclusion in the study

Exclusion Criteria:

* Mothers with evidence of clinical disease (diabetes, preeclampsia, hypertension). Babies with congenital malformations and intrauterine growth restriction.

Primary outcomes:
measure: Effects of Timing of Cord Clamping on Serum Calcium Levels in Neonates
timeFrame: at 6 hours of life
Secondary outcomes:
Other outcomes:
Locations:
city: Rawalpindi
country: Pakistan
facility: Pak Emirates Military Hospital
state: Punjab
Study officials:
affiliation: Military Hospital Rawalpindi
name: Arshad Khushdil, MBBS
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT06185933: Lidocaine Spray vs Viscous Lidocaine Solution Plus Lidocaine Spray in Patients Undergoing Non-Sedated EGD
Official title: Lidocaine Spray vs Viscous Lidocaine Solution Plus Lidocaine Spray in Patients Undergoing Non-Sedated Esophagogastroduodenoscopy: A Randomized Controlled Trial
Study type: INTERVENTIONAL
Overall status: ENROLLING_BY_INVITATION
Phase: NA
Conditions: Pain
Satisfaction, Patient
Keywords: lidocaine spray
lidocaine solution
non-sedating EGD
Lead sponsor: Sawanpracharak hospital
Sponsor class: OTHER
First posted: 2023-12-29
Enrollment: 250
Sex: ALL
Minimum age (years): 18
Maximum age (years): 80
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: This study aimed to compare the efficacy of lidocaine spray (S) alone versus lidocaine spray combined with lidocaine viscous solution (S+V) in facilitating pharyngeal observation during Non-sedating upper gastrointestinal endoscopy (UGE).

Detailed description: A randomized controlled trial was conducted between July and October 2023 at Sawanpracharak hospital, Thailand. Of 250 patients undergoing UGE, 125 were randomly assigned to group S (lidocaine spray alone) and 125 to group S+V (lidocaine spray plus lidocaine viscous solution). The total dose of lidocaine did not exceed 5 mg/kg in both groups

Eligibility criteria: Inclusion Criteria:

* Patients scheduled for upper gastrointestinal endoscopy:
* Patients who are robust, without chronic illnesses, or with controlled chronic conditions that do not adversely affect the function of any organ (American Society of Anesthesiologists (ASA) physical status classification I-II).

Exclusion Criteria:

* Has a history of receiving painkillers or sleeping pills within 24 hours before the endoscopy.
* Has a history of post-endoscopy nausea and vomiting.
* Patients who have undergone upper gastrointestinal endoscopy previously.
* Has chronic conditions such as epilepsy, vertigo, or mental health disorders.
* Has a history of allergy to anesthesia used in the study.
* Pregnant or currently breastfeeding.
* Refuses to participate in the study.

Primary outcomes:
measure: procedural pain, measured using the visual analog scale (VAS).
timeFrame: 30 minute after finished precedure
Secondary outcomes:
measure: patient tolerance
timeFrame: immediately after finished precedure
measure: endoscopist satisfaction
timeFrame: immediately after finished precedure
measure: patient satisfaction
timeFrame: 30 minute after finished precedure
Other outcomes:
Locations:
city: Nakhon Sawan
country: Thailand
facility: Sawanpracharak hospital
state: Nakhonsawan
Study officials:
affiliation: Saawanpracharak hospital Thailand
name: Natee Faknak
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT04395833: National Survey on the Lockdown of Children With Disabilities
Official title: Emerging Health Challenges for Children With Motor Disabilities and Their Parents Facing the COVID-19 Pandemic: Messages From Families Answering the ECHO French National Survey
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Identify Emerging Health Challenges for Children With Motor Disabilities and Their Parents Facing the COVID-19 Pandemic
Lead sponsor: University Hospital, Brest
Sponsor class: OTHER
First posted: 2020-05-20
Enrollment: 2500
Sex: ALL
Maximum age (years): 18
Standard ages: CHILD
ADULT
Accepts healthy volunteers: yes
Observational model: FAMILY_BASED
Time perspective: CROSS_SECTIONAL
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Children with motor disabilities, with and without associated impairement

Brief summary: During the COVID-19 pandemic, lockdown measures were established in France affecting the life course of children with disabilities. This study aimed at identifying the experiences, main difficulties and needs of these children and their parents during the lockdown period.


Eligibility criteria: Inclusion Criteria:

-children (age 0-18 years) with motor disabilities (with and without associated impairement), living in France.

Exclusion Criteria:

-

Primary outcomes:
measure: Experience during lockdown
timeFrame: From the 6th of April 2020 until the 11th of May 2020
measure: Health risk during lockdown
timeFrame: From the 6th of April 2020 until the 11th of May 2020
measure: Impact on medical and rehabilitation follow up
timeFrame: From the 6th of April 2020 until the 11th of May 2020
measure: Impact on daily living
timeFrame: From the 6th of April 2020 until the 11th of May 2020
Secondary outcomes:
measure: Experience during lockdown
timeFrame: From the 24th of April 2020 until the 11th of May 2020
Other outcomes:
Locations:
city: Brest
country: France
facility: CHRU de Brest
Study officials:
References:
Clinical trial NCT03201133: Clinical Subgroups in Patellofemoral Pain Syndrome
Official title: Clinical Subgroups Identification in Patellofemoral Pain Syndrome Patients
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Patellofemoral Pain Syndrome
Lead sponsor: Federal University of Rio Grande do Sul
Sponsor class: OTHER
First posted: 2017-06-28
Enrollment: 45
Sex: FEMALE
Minimum age (years): 18
Maximum age (years): 45
Standard ages: ADULT
Observational model: CASE_CONTROL
Time perspective: RETROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Patellofemoral pain syndrome women

Brief summary: Patellofemoral pain syndrome (PFPS) is a multifactorial pathology characterized by diffuse retropatellar and peripatellar pain in the knee joint, exacerbated by overloading activities on the patellofemoral joint. However, this disease showed high degree of patients not responsive to therapeutic strategies. This condition occurred because several factors is related to disease such as: (1) proximal factors (involving trunk and hip), (2) local factors (surrounding and or within the patellofemoral joint) and (3) distal factors (involving ankle and foot). Thus, the identification of clinical subgroups based in anatomic changes (proximal, local and distal factors) is a recent strategy that could help in the therapeutic strategies focused on the etiology of the disease, improve responsiveness to treatment, clinical and functional benefits.


Eligibility criteria: Inclusion Criteria:

* Peripatellar or retropatellar pain in at least two of the following situations: squatting, running, kneeling, jumping, climbing or descending stairs and sitting for a prolonged period of time for at least three months.

Exclusion Criteria:

* Engaged in systematic exercise with focus on lower limb in the last six months and Had an injury to the hip and ankle joint in the last 12 months.

Primary outcomes:
measure: Muscular strength tests of hip and knee muscles.
timeFrame: 1 day
measure: Muscle thickness measures
timeFrame: 1 day
measure: Muscle activation of knee, hip and foot muscles
timeFrame: 1 day
measure: Kinematics during unilateral squat
timeFrame: 1 day
measure: Fascicle length measures
timeFrame: 1 day
measure: Pennation angle measures
timeFrame: 1 day
Secondary outcomes:
Other outcomes:
Locations:
city: Pôrto Alegre
country: Brazil
facility: Exercise Research Laboratory
state: Rio Grande Do Sul
Study officials:
References:
Clinical trial NCT04609033: Implications of Different Analgesic Models on Inflammatory Markers After Laparoscopic Cholecystectomy
Official title: Implications of Different Analgesic Models on Inflammatory Markers After Laparoscopic Cholecystectomy
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Perioperative Pain
Lead sponsor: Assiut University
Sponsor class: OTHER
First posted: 2020-10-30
Enrollment: 110
Sex: ALL
Minimum age (years): 18
Maximum age (years): 55
Standard ages: ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: Postoperative abdominal and shoulder pain that are experienced in patients undergoing laparoscopic cholecystectomy (LC) is significant. Although it is generally less sever than post open cholecystectomy pain, it still causes an avoidable distress in the first 24 hours postoperatively

Detailed description: The incidence of pain after laparoscopy may be as high as 36 to 63 percent and is attributed to the carbon dioxide gas (CO2) used to induce pneumo-peritoneum1.

The residual part of CO2 remains in the peritoneal cavity for several days after the operation and causes stretching of the phrenic nerve endings, local hypothermia, and diaphragmatic irritation by carbonic acid formation

Eligibility criteria: Inclusion Criteria:

* Patients scheduled for Laparoscopic cholecystectomy.
* Age spectrum of 18 - 55 years
* ASA I, II
* Have no comorbid chronic medical diseases

Exclusion Criteria:

* Patients with co morbid medical diseases
* Age outside the specified range
* Acute inflammation of the gall bladder
* Critically ill patient
* Emergency operations
* Patient refusal

Primary outcomes:
measure: postoperative level of ACTH hormone
timeFrame: 6 hours
Secondary outcomes:
measure: VISUUEAL ANALOGE SCORE
timeFrame: 24 hours
Other outcomes:
Locations:
city: Assiut
country: Egypt
facility: Assiut University Hospitals
Study officials:
References:
Clinical trial NCT05721833: Effect of Noninvasive High Frequency Oscillatory Ventilation on Improving CO2 Clearance in COPD Patients
Official title: Effect of Noninvasive High Frequency Oscillatory Ventilation on Improving Carbon Dioxide Clearance in COPD Patients : a Clinical Crossover Trial
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: COPD Exacerbation
Non-invasive Ventilation
Keywords: Noninvasive ventilation
High frequency oscillatory ventilation
COPD
Lead sponsor: Guangzhou Institute of Respiratory Disease
Sponsor class: OTHER
First posted: 2023-02-10
Enrollment: 12
Sex: ALL
Minimum age (years): 40
Maximum age (years): 80
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: CROSSOVER
Intervention model description: Patients were randomized to receive one hour each of the two non-invasive ventilation modes before and after, and one hour of washout after receiving the first mode of ventilation before receiving the second intervention.
Primary purpose: TREATMENT

Brief summary: High-frequency oscillatory ventilation (HFOV), as an ideal lung-protecting ventilation method, has been gradually used in neonatal critical care treatment, and is currently recommended as a rescue method for neonatal acute respiratory distress syndrome (ARDS) after failure of conventional mechanical ventilation. . Although its ability to improve oxygenation and enhance carbon dioxide (CO2) scavenging has been repeatedly demonstrated in laboratory studies, its impact on clinical outcomes in these patients remains uncertain. Non-invasive high-frequency oscillatory ventilation (nHFOV) combines the advantages of HFOV and non-invasive ventilation methods, and has become a current research hotspot in this field. It is recommended to be used to avoid intubation after conventional non-invasive ventilation therapy fails. For the treatment of intubation, there is still a lack of large-scale clinical trials to systematically explore its efficacy. The gradual increase in the clinical application of nHFOV has also enriched its use in the treatment of other diseases


Eligibility criteria: Inclusion Criteria:

1. Age 40-80, males and females;
2. Stage III and IV COPD and PaCO2≥50mmHg;
3. Similar with non-invasive ventilation;
4. Willing to participate in the study;
5. Able to provide informed consent.

Exclusion Criteria:

1. Bronchiectasis; post-tuberculosis sequelae; rib cage deformities; neuromuscular disorders; and bronchial carcinoma.
2. Intolerant with NIV

Primary outcomes:
measure: Partial pressure of carbon dioxide in peripheral blood
timeFrame: within 50 minutes after intervention
Secondary outcomes:
measure: Asynchrony index
timeFrame: within 50 minutes after intervention
Other outcomes:
Locations:
Study officials:
References:
Clinical trial NCT02028533: Cocaine Opioid Oxytocin Option - Limited
Official title: Chronic Intranasal Oxytocin as an Adjunct to Methadone Maintenance Treatment in Patients With Co-occuring Opioid Use Disorder and Cocaine Use: A 2-week Pilot Study
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE1
Conditions: Opioid Use Disorder
Cocaine Use Disorder
Keywords: addiction
oxytocin
tolerability
Lead sponsor: University of California, San Francisco
Sponsor class: OTHER
First posted: 2014-01-07
Enrollment: 30
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: SINGLE_GROUP
Primary purpose: OTHER

Brief summary: This is a pilot feasibility study assessing the tolerability of chronic administration of intranasal oxytocin to patients receiving methadone at an opioid replacement clinic who are actively using cocaine.


Eligibility criteria: Inclusion Criteria:

* Enrolled as a patient in the San Francisco General Hospital Opioid Treatment Outpatient Program
* Stable dose of methadone for at least the past two weeks
* At least one routine urine toxicology screen positive for cocaine in the past month

Exclusion Criteria:

* Positive urine pregnancy test
* Use of illicit drugs in the past month (with the exception of cocaine or cannabis)
* Currently meets Diagnostic and Statistical Manual-5 (DSM-V) criteria for severe major depressive disorder with suicidal thoughts or actions
* History of psychotic or moderate-severe alcohol use disorder as defined by DSM-V criteria
* Severe neuropsychological disorder, brain trauma, epilepsy
* Sensitivity to preservatives (in particular E 216, E 218 and chlorobutanol hemihydrate)
* Nasal obstruction, discharge, or bleeding
* Habitually drinks large volumes of water
* Taking testosterone, estrogen/progesterone supplement, or serotonin-1a receptor agonists/antagonists

Primary outcomes:
measure: Number of patients with non-serious and serious adverse events
timeFrame: 3 weeks
Secondary outcomes:
Other outcomes:
Locations:
city: San Francisco
country: United States
facility: San Francisco General Hospital Opiate Treatment Outpatient Program
state: California
Study officials:
affiliation: University of California, San Francisco
name: Christopher S Stauffer, MD
role: PRINCIPAL_INVESTIGATOR
affiliation: University of California, San Francisco
name: Joshua Woolley, MD, PhD
role: STUDY_DIRECTOR
References:
Clinical trial NCT01913587: Efficacy Study of Acupuncture on Spinal Compression Fracture
Official title: Efficacy and Safety of Acupuncture on Spinal Compression Fracture in Patients Treated With Nerve Block
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Spinal Compression Fracture
Lead sponsor: Daegu Catholic University Medical Center
Sponsor class: OTHER
First posted: 2013-08-01
Enrollment: 14
Sex: ALL
Minimum age (years): 50
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: This study is to investigate the effectiveness of acupuncture for alleviating pain from Spinal Compression Fracture in Patients Treated with Nerve Block.

Detailed description: Spinal compression fracture is mainly caused by trauma, furthermore, in old age, osteoporosis increases the risk of spinal compression fracture. Nerve block is effective for the management of pain from inflammation or nerve root stimulation from spinal compression fracture. As one of alternative interventions, acupuncture is effective for controlling spinal compression fracture.

This study aims to investigate that combination with acupuncture and nerve block may relieve spinal compression fracture-related pain versus nerve block alone.

Eligibility criteria: Inclusion Criteria:

* Vertebral compression fracture by trauma or osteoporosis
* Minimum 15% height loss of vertebrae
* Patient diagnosed with x-ray or computed tomography (CT) or magnetic resonance image (MRI)
* Visual analogue scale (VAS) score of 5 or more
* Age over 50
* 2 weeks from onset or more
* Follow-up possible during the clinical trial
* Written informed consent voluntarily

Exclusion Criteria:

* Within 2 weeks from onset
* Pathological fracture due to malignancy/myeloma, osteomyelitis
* Major retropulsion of bony segments into the spinal canal
* Bone metabolic disease
* Significant renal or hepatic disease
* Hypersensitive reaction to acupuncture treatment
* Senile dementia, impaired cognitive function or other cerebral disease, severe psychiatric or psychological disorders
* Alcohol/drug abuse

Primary outcomes:
measure: Visual analogue scale (VAS)
timeFrame: Change from baseline to 5 weeks
Secondary outcomes:
measure: Short form McGill pain questionnaire
timeFrame: Change from baseline to 5 weeks
measure: Oswestry Disability Index (ODI)
timeFrame: Change from baseline to 5 weeks
Other outcomes:
Locations:
city: Daegu
country: Korea, Republic of
facility: Daegu Catholic University Medical Center
state: Kyungsangbukdo
Study officials:
affiliation: Comprehensive and Intergrative Medicine Institute
name: Jeong-Chul Seo, KMD, Ph.D
role: PRINCIPAL_INVESTIGATOR
affiliation: Daegu Oriental Hospital of Daegu Haany University
name: Min-Ah Gwak, KMD, Ph.D
role: PRINCIPAL_INVESTIGATOR
affiliation: Comprehensive and Integrative Medicine Insitute
name: Seong-Hoon Park, KMD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT01231087: Energy Expenditure Pre and Post Bariatric Surgery
Official title: Energy Expenditure in Patients Pre and Post Bariatric Surgery
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Bariatric Surgery
Keywords: energy expenditure
morbid obesity
bariatric surgery
nutritional follow-up
Lead sponsor: Gastrocirurgia, Brazil
Sponsor class: OTHER
First posted: 2010-11-01
Enrollment: 32
Sex: ALL
Minimum age (years): 18
Maximum age (years): 75
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Obese petiets

Brief summary: Obese patients are going to be submitted to indirect calorimetry pre-operatively and we are going to repeat the same exam 6 months after bariatric surgery (post Roux-en-Y gastric Bypass surgery). They are going to do also body composition analysis in both moments.

The investigators are going to compare the results to see if the bariatric surgery increases their energy expenditure.


Eligibility criteria: Inclusion Criteria:

* obese patients that will be submitted to bariatric procedure

Exclusion Criteria:

* patients that don´t have clinical conditions to be submitted to a bariatric procedure

Primary outcomes:
Secondary outcomes:
Other outcomes:
Locations:
city: Brasilia
country: Brazil
facility: Gastrocirurgia
state: Distrito Federal
Study officials:
References: