Clinical trial NCT06992206: What Lies Beneath the Stone? Metabolic Insights From Composition-Based Analysis of Kidney Stones
Official title: What Lies Beneath the Stone? Metabolic Insights From Composition-based Analysis of Kidney Stones
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Urolithiasis, Calcium Oxalate
Keywords: Calcium oxalate
Metabolic evaluation
Urolithiasis
Stone composition
Lead sponsor: Hisar Intercontinental Hospital
Sponsor class: OTHER
First posted: 2025-05-28
Enrollment: 506
Sex: ALL
Minimum age (years): 18
Maximum age (years): 80
Standard ages: ADULT
OLDER_ADULT
Observational model: COHORT
Time perspective: RETROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: This study included 506 patients who presented with nephrolithiasis and underwent metabolic evaluation of stone composition. Data were collected retrospectively from medical records at Hisar Intercontinental Hospital between 2010 and 2024.

Brief summary: This retrospective observational study investigates the metabolic abnormalities associated with different types of kidney stones by analyzing their composition. The study includes adult patients diagnosed with urolithiasis, whose stone samples were analyzed using Fourier Transform Infrared (FTIR) spectroscopy. Clinical, biochemical, and 24-hour urine metabolic parameters were compared between first-time and recurrent stone formers, and among subtypes of calcium oxalate stones (monohydrate vs. dihydrate). The goal is to identify metabolic risk factors that contribute to stone formation and recurrence, and to provide insights for individualized prevention strategies.

Detailed description: This retrospective study aims to evaluate the metabolic characteristics of patients with urolithiasis based on kidney stone composition. Data were collected from patients treated for kidney stones between January 2010 and December 2024 at a tertiary urology center. Stone analysis was performed using FTIR spectroscopy, classifying stones into subtypes including calcium oxalate monohydrate (COM), calcium oxalate dihydrate (COD), uric acid, and mixed types.

Serum levels of calcium, phosphorus, uric acid, creatinine, and parathyroid hormone (PTH), along with 24-hour urine values (calcium, oxalate, citrate, uric acid, volume, and pH), were recorded. The study primarily compares metabolic differences between:

First-time vs. recurrent stone formers

COM vs. COD stone subtypes

Findings from this study are expected to improve understanding of metabolic risk factors and contribute to the development of tailored metabolic evaluations and dietary or pharmacological preventive strategies for recurrent stone formers.

Eligibility criteria: Inclusion Criteria:

* Age ≥ 18 years
* Patients diagnosed with kidney stones between January 2010 and December 2024
* Stone composition analyzed via Fourier-transform infrared (FTIR) spectroscopy
* Available metabolic panel including serum and 24-hour urine values

Exclusion Criteria:

* Patients with secondary hyperparathyroidism, renal tubular acidosis, or other systemic metabolic diseases affecting stone formation
* Patients with incomplete medical records
* Patients with non-calcium-based stones (e.g., uric acid, struvite, cystine)

Primary outcomes:
measure: Kalsiyum oksalat taşı tipine göre serum ve 24 saatlik idrar parametrelerinin dağılımı Zaman Çerçevesi (Time Frame): 01 Ocak 2010 - 31 Aralık 2024 tarihleri arasında toplanan hasta verileri
timeFrame: January 2010 and December 2024
Secondary outcomes:
Other outcomes:
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