louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT03089242: MicroRNAs in Acute Kidney Injury
Official title: MicroRNAs in Acute Kidney Injury (MIRAKI) - a Pilotstudy -
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Kidney Injury in Cardiac Surgery - Expression of microRNAs
Lead sponsor: Heinrich-Heine University, Duesseldorf
Sponsor class: OTHER
First posted: 2017-03-24
Enrollment: 150
Sex: ALL
Minimum age (years): 18
Maximum age (years): 90
Standard ages: ADULT
OLDER_ADULT
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Cardiac surgery patients

Brief summary: Profiling of microRNAs and long noncoding RNAs (lncRNAs) in patients undergoing cardiac surgery. Analysis: Prediction of acute kidney injury by plasma expression profile of microRNAs?

Detailed description: In this pilot study we will include 150 patients undergoing cardiac surgery in a German university hospital. We will profile microRNA expression in plasma and urine before and at several timepoints after surgery. We will use a preselected panel of microRNAs and lncRNAs for analysis. Goal is to identify microRNAs/lncRNAs that are able to predict the occurence of AKI in these patients.

Eligibility criteria: Inclusion Criteria:

* cardiac surgery

Exclusion Criteria:

* preexisting chronic kidney injury
* inclusion in another study
* pregnancy
* Kidney transplantation in history
* GFR \< 30 ml/min (glomerular filtration rate)
* ECLS therapy (extracorporal life support)

Primary outcomes:
measure: acute kidney injury
timeFrame: 1 year
Secondary outcomes:
Other outcomes:
Locations:
city: Düsseldorf
country: Germany
facility: Klinik für Anästhesiologie
Study officials:
affiliation: Klinik für Anästhesiologie, Heinrich-Heine-Universität Düsseldorf
name: Timo Brandenburger, M.D.
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT04789642: Nurses Education Using Virtual Social Network
Official title: Effect of an Educational Program Using Virtual Social Network on Nurses' Knowledge and Skill of Blood Pressure Measurement
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Blood Pressure Determination
Continuing Nursing Education
Education, Distance
Lead sponsor: Mansoura University
Sponsor class: OTHER
First posted: 2021-03-09
Enrollment: 70
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: OTHER

Brief summary: Regardless of the method used to measure BP, initial and ongoing training of technicians and healthcare providers and the use of validated and calibrated devices are critical for obtaining accurate BP measurements.

Detailed description: Shortage of human resources and the importance of remaining up-to-date to provide healthcare services highlighted the development of distance education for nurses. In addition information presented via the distance learning method via software systems was more stable than the face-to-face method via lecture, and it saved time and energy. Nurses are responsible for BP monitoring and assessment in the clinical setting. Finding new strategies for distance education is of great concern and ,compared with traditional face-to-face interventions, those carried out through social networks have the advantage that the participant does not need to attend the sessions in person, and offers unlimited access to the intervention materials whenever they wish.

Eligibility criteria: Inclusion Criteria:

* Only permanent staff nurses working in the two cardiac units.
* Nurses of both sexes .
* Nurses who use a smart phone or any other digital device with the ability to install the social network of whatsapp.

Exclusion Criteria:

* Inaccessibility to wireless net work
* Unwillingness to participate in study
* Failure to fill pretest questionnaire

Primary outcomes:
measure: change in blood pressure measurement skill score
timeFrame: will be measured at baseline and at the end of study (after 1 month)
measure: change in Blood Pressure Measurement Knowledge score
timeFrame: will be measured at baseline and at the end of the study (after 1 month)
Secondary outcomes:
Other outcomes:
Locations:
city: Mansoura
country: Egypt
facility: Faculty of Nursing Mansoura University
Study officials:
References:
Clinical trial NCT04207242: Social Media Use of Psoriasis Vulgaris Patients: Multicenter, Survey Work
Official title: Social Media Use of Psoriasis Vulgaris Patients: Multicenter, Survey Work
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Psoriasis Vulgaris
Lead sponsor: Istanbul Medeniyet University
Sponsor class: OTHER
First posted: 2019-12-20
Enrollment: 1520
Sex: ALL
Minimum age (years): 18
Maximum age (years): 90
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: ECOLOGIC_OR_COMMUNITY
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: psoriasis vulgaris patients

Brief summary: Psoriasis Vulgaris is a chronic, recurrent, inflammatory and hyperproliferative skin disease. Joint involvement is common along with skin involvement. However, metabolic diseases, such as cardiovascular diseases can be accompanied by many systemic diseases, chronic and repetitive due to the quality of life and psychological status of patients can affect. For this reason, patients carry out various research on their diseases on social media and follow programs on these issues in other media such as television and radio. However, there is no study on how much patients are interested in these publications, how much they trust them, and how they reach and organize information via social media. The aim of the study will be to clarify how and how patients with Psoriasis Vulgaris use social media to obtain information about the diagnosis and treatment of their disease, the interaction of patient groups with each other, and how often social media is used, especially in which group of patients.


Eligibility criteria: Inclusion Criteria:

* Psoriasis vulgaris patients

Exclusion Criteria:

* patients that don't want to answer questions

Primary outcomes:
measure: Social media use of psoriasis vulgaris patients, a questionnaire will be asked the patients and try to learn how they use social media for getting information about their disease.
timeFrame: July 2020
Secondary outcomes:
Other outcomes:
Locations:
city: Istanbul
country: Turkey
facility: Melek Aslan Kayıran
Study officials:
References:
Clinical trial NCT00552942: Randomized Controlled Trial of Laparoscopic Gastric Bypass Plus Omentectomy Versus Laparoscopic Gastric Bypass Alone in Improving Diabetic Indices
Official title: Randomized Controlled Trial of Laparoscopic Gastric Bypass Plus Omentectomy Versus Laparoscopic Gastric Bypass Alone in Improving Diabetic Indices
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: PHASE3
Conditions: Diabetes
Interleukins
Cytokines
Keywords: obesity
diabetes
cytokines
Lead sponsor: Legacy Health System
Sponsor class: OTHER
First posted: 2007-11-02
Enrollment: 40
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: To see if removing the omentum in addition to a gastric bypass improves diabetes is better than just a gastric bypass.


Eligibility criteria: Inclusion Criteria:

* undergoing laparoscopic gastric bypass, \>18 yo, understands english

Exclusion Criteria:

* previous lower pelvic surgery, self-pay patients, previous weight loss surgery,

Primary outcomes:
measure: diabetic indices
timeFrame: 6 months
Secondary outcomes:
measure: interleukin and cytokine levels, weight loss
timeFrame: 6 months
Other outcomes:
Locations:
city: Portland
country: United States
facility: Oregon Weight Loss Surgery LLC
state: Oregon
Study officials:
affiliation: Oregon Weight Loss Surgery, LLC
name: Dennis Hong, MD., MS.c, FRCSC
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT02597842: Transcutaneous Electrical Acupoint Stimulation(TEAS) for Postoperative Nausea and Vomiting in Laparoscopic Operation
Official title: Efficiency of Transcutaneous Electrical Acupoint Stimulation(TEAS) With Single Acupoint or Two Acupoints for Postoperative Nausea and Vomiting in Laparoscopic Operation: A Single Center, Randomized, Double-blinded, Controlled Clinical Trial
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Postoperative Nausea and Vomiting
Keywords: Postoperative nausea and vomiting
TEAS
Lead sponsor: Xijing Hospital
Sponsor class: OTHER
First posted: 2015-11-05
Enrollment: 180
Sex: ALL
Minimum age (years): 18
Maximum age (years): 65
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: This is a single center, randomized, double-blinded, controlled clinical trial.The purpose of this study is to compare the effect of TEAS pretreatment with single acupoint or two acupoints for postoperative nausea and vomiting in patients undergoing laparoscopic operation.

Detailed description: Patients were randomly assigned to four groups, receiving TEAS 30 minutes before induction.The stimulation was applied until the end of the operation. Postoperative nausea and vomiting was recorded 30 minute, 2 hour, 6 hour and 24 hour after the operation. The adverse events were recorded as well.

Eligibility criteria: Inclusion Criteria:

1. ASA I-III
2. Aged 18 to 65 years old
3. Scheduled for general anesthesia
4. BMI index is between 18 to 30
5. Informed consented

Exclusion Criteria:

1. ASA IV
2. Hypertension that is not controlled
3. Severe hepatic or renal dysfunction
4. Ever had received electrical stimulation treatment
5. Severe systemic infection
6. With contraindications to the use of TEAS, such as skin damage or infection at the acupoints
7. For any reason one can not cope with the studies, such as the following:

   language comprehension, mental illness
8. Participate in the other clinical trial 3 month before the enrollment

Primary outcomes:
measure: The incidence of postoperative nausea and vomiting
timeFrame: within 24 hours after operation
Secondary outcomes:
measure: Incidence of other postoperative complications
timeFrame: 30minutes, 2hours, 6hours and 24 hours after operation
measure: Postoperative nausea and vomiting（PONV） score
timeFrame: 30minutes, 2hours, 6hours and 24 hours after operation
measure: Visual Analogue Scale (VAS) pain score in PACU
timeFrame: 30 minutes after operation
measure: Change of concentration of serum 5-HT
timeFrame: intraoperative
measure: Change of concentration of serum dopamine
timeFrame: intraoperative
Other outcomes:
Locations:
city: Xi'an
country: China
facility: Xijing Hospital, Fourth Military Medical University
state: Shaanxi
Study officials:
affiliation: Air Force Military Medical University, China
name: Lizhe Xiong, M.D.;Ph D
role: STUDY_CHAIR
References:
Clinical trial NCT02356042: Effects of Geriatric Inclusive Art Activity in Nursing Home Residents (GIA)
Official title: Effects of Geriatric Inclusive Art Activity in Nursing Home Residents (GIA)
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Geriatric Disorders
Lead sponsor: University Hospital, Angers
Sponsor class: OTHER_GOV
Collaborators: name: Cémavie
First posted: 2015-02-05
Enrollment: 24
Sex: ALL
Minimum age (years): 65
Standard ages: OLDER_ADULT
Accepts healthy volunteers: no
Observational model: CASE_CONTROL
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Patients were recruited in nursing home.

Brief summary: The study aimed to compare the changes in health and functional status between nursing home residents practicing GIA activity and a control group of residents, and to examine the changes in residents' abilities to participate in GIA activity.

Detailed description: Geriatric inclusive art (GIA) activity is a derived form of art therapy using painting to make older adults aware of their abilities through an improvement of emotional well-being (1). GIA protected against in-hospital mortality in demented older inpatients and has also been associated with shorter length of hospital stay in geriatric inpatients. These GIA-related positive effects suggest that GIA activity may improve health and functional status in the elderly. To date, effects of GIA on health and functional status in nursing home residents have not been examined.

Based on the previous positive effects reported in older inpatients practicing GIA activity, the investigators hypothesized that GIA activity could improve health and/or functional status of nursing homes residents.

Eligibility criteria: Inclusion Criteria:

* Being a resident in the nursing home "la Grande Providence" (Nantes - Loire Atlantique, France)
* Ability to answer questions
* Being affiliated to the French health insurance

Exclusion Criteria:

* Inability to understand and speak French
* Opposition to the use of information collected for research purposes

Primary outcomes:
measure: Change in health and functional status measured by a standardized questionnaire
timeFrame: This outcome is assessed at baseline and at 6 months
Secondary outcomes:
measure: Change in the number of drugs daily taken assessed by a standardized questionnaire
timeFrame: This outcome is assessed at baseline and at 6 months
measure: History of falls in the past 6 months assessed by a standardized questionnaire
timeFrame: This outcome is assessed at baseline and at 6 months
measure: Have an unscheduled medical consultation assessed by a standardized questionnaire
timeFrame: This outcome is assessed at baseline and at 6 months
measure: Being hospitalized unscheduled manner assessed by a standardized questionnaire
timeFrame: This outcome is assessed at baseline and at 6 months
Other outcomes:
Locations:
city: Nantes
country: France
facility: Fondation Cémavie
Study officials:
affiliation: Angers University Hospital
name: Olivier Beauchet, MD, PhD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT05282342: Heart Transplant Patients, Health Status and Physical Activity
Official title: Comparative Analysis of the Health Status of Heart Transplant Patients With Different Levels of Physical Activity
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Disease, Chronic
Lead sponsor: University of Oviedo
Sponsor class: OTHER
First posted: 2022-03-16
Enrollment: 72
Sex: ALL
Minimum age (years): 18
Maximum age (years): 90
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: OTHER
Time perspective: CROSS_SECTIONAL
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Active and sedentary heart transplant patients and sedentary healthy people.

Brief summary: The aim of this cross-sectional observational study is (1) to assess the health status of a group of heart transplant patients and their level of physical activity, (2) and to compare the health status of a group of heart transplant patients with different levels of physical activity, with a group of healthy people classified as sedentary (due to their level of physical activity).


Eligibility criteria: Inclusion Criteria:

* Heart transplant adults (18 years old) whose transplant had taken place at least twelve months before the study data was taken.
* Heart transplant patients with low, moderate and high levels of physical activity, according to the results of the International Physical Activity Questionnaire - Long Form (IPAQ-L).
* Healthy people with low levels of physical activity, according to the results of the International Physical Activity Questionnaire - Long Form (IPAQ-L).

Exclusion Criteria:

* Do not meet the eligibility criteria.
* Have physical disabilities and/or other limiting pathologies that would condition their level of physical activity.
* Have participated in cardiac rehabilitation programs during the twelve months prior to the study.

Primary outcomes:
measure: Cardiovascular function assessment.
timeFrame: Through study completion, an average of 1 year.
measure: Neuromuscular function assessment.
timeFrame: through study completion, an average of 1 year
Secondary outcomes:
measure: Basic blood analysis
timeFrame: Through study completion, an average of 1 year.
measure: Flexibility
timeFrame: Through study completion, an average of 1 year.
measure: Balance
timeFrame: Through study completion, an average of 1 year.
measure: Functional Capacity
timeFrame: Through study completion, an average of 1 year.
measure: Quality of Life Status
timeFrame: Through study completion, an average of 1 year.
Other outcomes:
Locations:
city: León
country: Spain
facility: Itziar Salas Reguera
state: León, Castilla Y León
Study officials:
References:
Clinical trial NCT01544842: Tacrolimus Ointment in Oral Lichen Planus
Official title: Comparison of Topical Tacrolimus, Triamcinolone and Placebo in the Treatment of Symptomatic Oral Lichen Planus
Study type: INTERVENTIONAL
Overall status: TERMINATED
Phase: NA
Conditions: Oral Lichen Planus
Keywords: Oral lichen planus
Tacrolimus ointment
Triamcinolone paste
Lead sponsor: University of Oulu
Sponsor class: OTHER
Collaborators: name: Kuopio University Hospital
First posted: 2012-03-06
Enrollment: 28
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The purpose of this study is to compare the effectiveness of topical tacrolimus, triamcinolone and placebo in alleviating signs and symptoms of oral lichen planus (OLP).


Eligibility criteria: Inclusion Criteria:

* Diagnosis of OLP made by a specialist in oral pathology based on clinical and histopathological features
* Clinical score for OLP ≥ 20 at baseline
* Symptomatic OLP at baseline
* Washout period of 2 weeks
* Age over 18

Exclusion Criteria:

* Pregnant or lactating women
* Allergy to tacrolimus or other macrolides
* Allergy to other drugs or substances used in the study
* Abnormal liver function
* Netherton's syndrome
* Cyclosporin medication
* Other regular medication that could have significant interactions with tacrolimus

Primary outcomes:
measure: Change in clinical score for OLP
timeFrame: 1,2,3,4,5,6,7,8 and 9 weeks, 6 months
Secondary outcomes:
Other outcomes:
Locations:
city: Kuopio
country: Finland
facility: Oral and Maxillofacial Diseases Clinic, Kuopio University Hospital
city: Oulu
country: Finland
facility: Department of Diagnostics and Oral Medicine, Institute of Dentistry, University of Oulu
Study officials:
affiliation: Department of Diagnostics and Oral Medicine, Institute of Dentistry, University of Oulu, Oulu, Finland
name: Tuula Salo, DDS, PhD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT04619342: Safety and Efficacy of GSMs-TACE Combined With Surgical Resection in the Treatment of Hepatocellular Carcinoma (HCC) With Type III Portal Vein Tumor Thrombus (PVTT)
Official title: Safety and Efficacy of GSMs-TACE Combined With Surgical Resection in the Treatment of Hepatocellular Carcinoma (HCC) With Type III Portal Vein Tumor Thrombus (PVTT): A Single Center, Open, Randomized Controlled Trial.
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Hepatocellular Carcinoma (HCC) With Type III Portal Vein Tumor Thrombus (PVTT)
Lead sponsor: Beijing Tsinghua Chang Gung Hospital
Sponsor class: OTHER
First posted: 2020-11-06
Enrollment: 98
Sex: ALL
Minimum age (years): 18
Maximum age (years): 75
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: A Single center, Open, Randomized Controlled Trial Evaluating the Safety and Efficacy of GSMs-TACE Combined with Surgical Resection in the Treatment of Hepatocellular Carcinoma (HCC) with Type III Portal Vein Tumor Thrombus (PVTT).


Eligibility criteria: Inclusion Criteria:

1. Confirmed diagnosis of HCC with PVTT involving the main portal vein, i.e. Type III PVTT according to Cheng's classification.
2. Confirmed abundant blood supply of tumor thrombus using Computed Tomography (CT) and Magnetic Resonance Imaging (MRI).
3. The tumor must be surgically resectable.
4. ECOG Performance Status 0-2.
5. Adequate liver function (Child-Pugh class A)
6. Life expectancy ≥ 3 months
7. Previous physical ablation is allowed.
8. Age 18 to 75 years
9. Able to sign and provide written informed consent.

Exclusion Criteria:

1. Patients previously took oral molecular targeted drug or received immunotherapy.
2. Patients with arteriovenous fistula.
3. Severe active infection \>grade 2 (except for Hepatitis B and C infection).
4. Concomitant malignant tumors in other organs.
5. Presence of severe cardiac, lung or kidney disease.
6. Pregnant or breast-feeding woman.
7. Patients with severe neuropathy and unable to report therapeutic effects.
8. Patients with severe atherosclerosis.
9. Patients with AIDS.
10. Severe hemorrhage of digestive tract within the 4 weeks prior to enrolment.
11. Severe thrombogenesis or embolic event within the 6 months prior to enrolment.
12. Currently enrolled or going to enroll in any other clinical trials.
13. Subject is not suitable to participate in the study as judged by investigator (poor patient compliance, inability to follow up).

Primary outcomes:
measure: Progression Free Survival（PFS）
timeFrame: 6 months
Secondary outcomes:
measure: Median Overall Survival (mOS)
timeFrame: 2 years
measure: Overall Survival
timeFrame: 3, 6, 12 and 18 months
measure: Adverse Events
timeFrame: 6 months
Other outcomes:
Locations:
city: Beijing
country: China
facility: Beijing Changgung Hospital
Study officials:
affiliation: Beijing Tsinghua Changgeng Hospital
name: Yuewei Zhang
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT00962442: N-Acetylcysteine in Severe Acute Alcoholic Hepatitis
Official title: N-Acetylcysteine for the Treatment of Alcoholic Hepatitis: a Belgian Multicenter Randomised Trial
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE3
Conditions: Alcoholic Hepatitis
Keywords: alcoholic hepatitis
N-Acetylcysteine
enteral nutrition
oxidative stress
severe acute alcoholic hepatitis
Lead sponsor: Erasme University Hospital
Sponsor class: OTHER
First posted: 2009-08-20
Enrollment: 44
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: Acute alcoholic hepatitis (AAH) is the most severe form of alcoholic liver disease (ALD) and is associated with a high risk of dying in the short term. Corticosteroids are generally recommended in patients with severe AAH, but its use is still controverted and contraindicated in case of active infection or gastrointestinal bleeding. Therefore, alternative therapeutic options are needed.Ethanol consumption results in the depletion of endogenous antioxidant capabilities and patients with ALD have evidence of antioxidant deficiencies.Due to its effects on glutathion stores restoration and as such the limitation of the oxidative stress and its good tolerance and safety profile, N-acetylcysteine (NAC) is an attractive agent for the treatment of AAH.In this context, we hypothesized that NAC might be beneficial in severe AAH.


Eligibility criteria: Inclusion Criteria:

* Biopsy proven alcoholic hepatitis
* Severe disease defined by a Maddrey score superior to 32

Exclusion Criteria:

* Neoplastic disease compromising 6 months survival
* HIV patients
* Hepatorenal syndrome

Primary outcomes:
measure: Six months survival
Secondary outcomes:
measure: Rate of infections, clinical and biological parameters
Other outcomes:
Locations:
city: Brussels
country: Belgium
facility: Erasme University Hospital
Study officials:
References: