Clinical trial NCT06262945: Comperasion the Postoperative Effect of Low Laser Therapy and Platelet Rich Fibrin on Mandibular Third Molar Surgery.
Official title: Comparative Examination of the Postoperative Effects of Low-laser Treatment and Platelet-rich Fibrin Applications After Mandibular Impacted Wisdom Teeth Extraction
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Impacted Third Molar Tooth
Keywords: platelet rich fibrin
comparison
low laser therapy
wisdom tooth
Lead sponsor: Near East University, Turkey
Sponsor class: OTHER
First posted: 2024-02-16
Enrollment: 60
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: COHORT
Time perspective: RETROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: community aged between 18-40 without any important systemic disease.

Brief summary: The aim of this study was investigate the comparison of postoperative effects of low laser treatment and platelet-rich fibrin application on mandibular impacted third molar tooth extraction. The study included a total of 60 patients with impacted mandibular third molar. Patients were evaluated in 4 randomly separated groups. In group 1, PRF was applied to the tooth socket. In group 2, PRF was applied to the tooth socket combined with Low Laser Treatment extraorally to the extraction area for three days within surgery day In group 3, Low Laser Treatment was applied to the extraorally to the extraction area for three days within surgery day. In group 4 (control group), tradional osteomy was made. The outcome variables were pain, swelling, the number of analgesics taken, and trismus. These variables were also assessed based on first, second, third, and seventh days following the operation. All of the 4 groups patients were prescribed an 875/125 mg amoxicillin/clavulanic acid tablet twice daily for five days.


Eligibility criteria: Inclusion Criteria:

* The patient had no systemic diseases, no taken opioids for a long period, no current infections or acute pericoronitis, no smoke or drink alcohol, no pregnancy, the absence of allergy to penicillin and presence of penicillin allergy.

Exclusion Criteria:

* pericoronitis, no inflammation

Primary outcomes:
measure: Visual analogue scale (VAS)
timeFrame: Day 1
measure: Visual analogue scale (VAS)
timeFrame: Day 2
measure: Visual analogue scale (VAS)
timeFrame: Day 3
measure: Visual analogue scale (VAS)
timeFrame: Day 7
measure: Trismus
timeFrame: Day 1
measure: Trismus
timeFrame: Day 2
measure: Trismus
timeFrame: Day 3
measure: Trismus
timeFrame: Day 7
measure: Swelling
timeFrame: Day 1
measure: Swelling
timeFrame: Day 2
measure: Swelling
timeFrame: Day 3
measure: Swelling
timeFrame: Day 7
Secondary outcomes:
measure: the number of analgesic tablets
timeFrame: Day 1
measure: the number of analgesic tablets
timeFrame: Day 2
measure: the number of analgesic tablets
timeFrame: Day 3
measure: the number of analgesic tablets
timeFrame: Day 7
Other outcomes:
Locations:
city: Nicosia
country: Cyprus
facility: Near East University
state: Lefkosa
Study officials:
affiliation: Near East University
name: Beste Erismen Agan
role: PRINCIPAL_INVESTIGATOR
References:
citation: Desmet KD, Paz DA, Corry JJ, Eells JT, Wong-Riley MT, Henry MM, Buchmann EV, Connelly MP, Dovi JV, Liang HL, Henshel DS, Yeager RL, Millsap DS, Lim J, Gould LJ, Das R, Jett M, Hodgson BD, Margolis D, Whelan HT. Clinical and experimental applications of NIR-LED photobiomodulation. Photomed Laser Surg. 2006 Apr;24(2):121-8. doi: 10.1089/pho.2006.24.121.
citation: Krynicka I, Rutowski R, Staniszewska-Kus J, Fugiel J, Zaleski A. The role of laser biostimulation in early post-surgery rehabilitation and its effect on wound healing. Ortop Traumatol Rehabil. 2010 Jan-Feb;12(1):67-79.
citation: Donmezer CM, Bilginaylar K. Comparison of the Postoperative Effects of Local Antibiotic versus Systemic Antibiotic with the Use of Platelet-Rich Fibrin on Impacted Mandibular Third Molar Surgery: A Randomized Split-Mouth Study. Biomed Res Int. 2021 Dec 2;2021:3040661. doi: 10.1155/2021/3040661. eCollection 2021.
citation: Feslihan E, Eroglu CN. Can Photobiomodulation Therapy Be an Alternative to Methylprednisolone in Reducing Pain, Swelling, and Trismus After Removal of Impacted Third Molars? Photobiomodul Photomed Laser Surg. 2019 Nov;37(11):700-705. doi: 10.1089/photob.2019.4696. Epub 2019 Oct 7.