Clinical trial NCT04091477: Impact of Neuropsychological Alteration of Patients With Eating Disorders
Official title: Impact of Neuropsychological Alteration of Decision-making Abilities on the Functioning of Patients With Eating Disorders
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Eating Disorder
Keywords: Anorexia nervosa
Bulimia
Binge eating disorders
Neuropsychology
neurocognition
Daily functioning
Lead sponsor: University Hospital, Montpellier
Sponsor class: OTHER
Collaborators: name: INSERM 1061-Montpellier
First posted: 2019-09-16
Enrollment: 200
Sex: ALL
Minimum age (years): 15
Maximum age (years): 65
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: OTHER
Time perspective: RETROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Patients with eating disorder

Brief summary: Eating disorders are multifactorial disorders currently conceptualized in a biopsychosocial model, but pathophysiology remains relatively unknown, and robust etiological models to guide treatment are therefore lacking. Different endophenotypes and neurocognitive vulnerability factors have been found in eating disorders including decision making abnormalities. The investigators hypothesize that decision making abnormalities are associated with a lower level of functioning and quality of life which could lead to social and interpersonal difficulties. The investigators also hypothesize that these anomalies are associated with a particular clinical profile (more restrictive profile, more hyperactivity, less insight on the disease and desire for care ...).

Detailed description: The investigators will recruit a total of 200 patients with an eating disorder in the university hospital of Montpellier.

Participation consists of a one-day visit with a multidisciplinary assessment. No action is specific to research. This is the usual management of patients with eating disorders addressed to our department.

Eligibility criteria: Inclusion criteria :

* Patient with an eating disorder according to DSM-V criteria
* Patient aged from 15 to 65 years
* Patient who performs the day-hospital evaluation
* Patient affiliated to a French social security system
* Patient able to understand the nature, the aim and the methodology of the study For minor one of the legal guardians gave his consent

Exclusion criteria:

* Patient in an unstable somatic state (eg severe metabolic disorder making impossible or unreliable neuropsychological assessments)
* Patient's refusal to participate
* Patient protected by law (guardianship or curatorship)
* Pregnant or nursing women. A dosage of βHCG will be performed to ensure the absence of pregnancy.

Primary outcomes:
measure: Level of functional impairment assessed by the clinician with the FAST scale
timeFrame: 1 day
Secondary outcomes:
measure: Decision making assessed by the Iowa Gambling Task
timeFrame: 1 day
measure: Level of cognitive flexibility assessed by the Brixton test
timeFrame: 1 day
measure: Level of central coherence assessed by the Rey Figure Test
timeFrame: 1 day
Other outcomes:
Locations:
city: Montpellier
country: France
facility: Uhmontpellier
Study officials:
affiliation: University Hospital, Montpellier
name: Sébastien Guillaume, PhD
role: PRINCIPAL_INVESTIGATOR
References: