louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT00172406: The Relation Between Serum Level of Amioterminal Propeptide of Type I Procollagen and Diastolic Dysfunction in Hypertensive Patients Without Diabetes Mellitus
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Hypertension
Lead sponsor: National Taiwan University Hospital
Sponsor class: OTHER
First posted: 2005-09-15
Sex: ALL
Minimum age (years): 0
Standard ages: CHILD
ADULT
OLDER_ADULT
Observational model: DEFINED_POPULATION
Time perspective: OTHER

Brief summary: In the present study, we assessed the relation between diastolic dysfunction and myocardial fibrosis in hypertensive patients without diabetes mellitus. A total of 20 medically treated ambulatory non-diabetic hypertensive patients with normal left ventricular (LV) systolic function were enrolled into this study. Myocardial fibrosis was evaluated by serum concentrations of amino-terminal propeptides of type I and III procollagen (PINP and PIIINP). All patients underwent examinations of diastolic function by echocardiography and technetium-99m (99mTc) radionuclide ventriculography. There were 8 patients with PINP ≦53 μg/l (group 1) and 12 patients with PINP \>53 μg/l (group 2). Patients in group 2 had significantly lower LV peak filling rate (PFR; 3.2 ± 0.3 vs. 2.5 ± 0.2 end-diastolic volume/s) and shorter time to PFR ( 257 ± 41 vs. 174 ± 22 ms). Besides, the group 2 patients also had lower right ventricle PFR (1.9 ± 0.2 vs. 1.5 ± 0.1 end-diastolic volume/s) and shorter time to PFR ( 221 ± 29 vs. 154 ± 29 ms). Echocardiographic parameters for LV diastolic dysfunction (E/A ratio of mitral flow, deceleration time of E flow, velocities of pulmonary venous flow \[retrograde A wave, systolic /diastolic velocity ratio\], isovolumetric relaxation time, Tei index) were all comparable between two groups. In multiple regression analysis, LV time to peak filling rate was the only parameter that independently predicted serum PINP level (p\<0.05). In conclusion, elevated serum PINP level reflected LV diastolic dysfunction in hypertensive patients without diabetes.


Eligibility criteria: Inclusion Criteria:

* We enrolled 20 medically treated ambulatory, non-diabetic, hypertensive patients in this study.

Exclusion Criteria:

* Patients with abnormal liver functions, leukocytosis, elevated serum levels of C-reactive protein, systolic dysfunction (LV ejection fraction \<50%) and LV hypertrophy due to etiologies other than hypertension were excluded from this study.

Primary outcomes:
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
affiliation: National Taiwan University Hospital
name: Yi-Lwun Ho, MD, PhD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT00471406: Photodynamic Therapy With Verteporfin for Corneal Neovascularization
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Corneal Neovascularization
Lead sponsor: Chonnam National University Hospital
Sponsor class: OTHER
First posted: 2007-05-09
Sex: ALL
Minimum age (years): 35
Maximum age (years): 70
Standard ages: ADULT
OLDER_ADULT
Allocation: NON_RANDOMIZED
Intervention model: SINGLE_GROUP
Primary purpose: TREATMENT

Brief summary: Purpose: To investigate the efficacy of photodynamic therapy with verteporfin for the treatment of patients with corneal neovascularization.

Design: Prospective, non-comparative case series. Participants: Eighteen eyes of 18 patients with stable corneal neovascularization who were refractory to conventional treatment.

Methods: The patients were treated with photodynamic therapy with verteporfin (6 mg/m2). Five patients were treated following penetrating keratoplasty, and 2 patients were treated before penetrating keratoplasty. Best corrected visual acuity and anterior segment photography were performed before and after treatment. The length of cumulative blood vessels and area of corneal neovascularization were measured.

Main outcome measures: Vascular occlusion, best corrected visual acuity, cumulative blood vessel length, and corneal neovascularization area.


Eligibility criteria: Inclusion Criteria:

* Patients with clinically stable corneal neovascularization who were not improved after treatment with 1% prednisolone acetate eyedrops instilled 4 times a day for at least 1 month

Exclusion Criteria:

* Individuals who had active keratitis with vessel proliferation, uncontrolled inflammation, active hepatitis or clinically significant liver disease, or porphyria or other porphyrin sensitivity

Primary outcomes:
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
affiliation: Chonnam natianl university hospital
name: Kyung chul Yoon, MD
role: STUDY_DIRECTOR
References:
Clinical trial NCT03716206: Exergames on Shoulder Pain and Motor Function
Official title: Effects of Exergames on Post-stroke Shoulder Pain and Motor Function
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Shoulder Pain
Stroke
Keywords: Shoulder Pain
Stroke
Motor function
Lead sponsor: National Yang Ming Chiao Tung University
Sponsor class: OTHER
First posted: 2018-10-23
Enrollment: 60
Sex: ALL
Minimum age (years): 20
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: This study is to investigate the effects of exergame on shoulder pain and motor function of upper extremity in individuals with stroke.

Detailed description: Background and Purpose: Stroke is a major cerebrovascular disorder causing various symptoms in the world. A substantial portion of those surviving from stroke typically experience neurological sequelae and stroke-related complications. Post stroke shoulder pain is a sensory disturbance is one of a common complication in patients with chronic stroke and may adversely affect patients' quality of life. Nowadays, exergame has been explored as an adjunct therapy for the management of pain for a number of conditions. This study is to investigate the effects of exergame on shoulder pain and motor function of upper extremity in individuals with stroke. Method: This is a randomized controlled trail. Sixty subjects with poststroke shoulder pain will be recruited and randomized into either the exergame (experimental) group or conventional (control) group. The intervention is one hour per day, four or five days per week for three weeks. The primary outcomes are Visual Analogue Scale, and Brief Pain Inventory - Short Form. The secondary outcomes are Fugl-Meyer Assessment for Upper Limb Extremity, Wolf motor function test and Shoulder Pain and Disability Index.

Eligibility criteria: Inclusion Criteria:

1. Unilateral hemiplegia caused by stroke
2. Modified Ashworth Scale ≤2。
3. Mini-Mental State Examination ≥24。
4. Age ≥20。
5. Shoulder pain 。

Exclusion Criteria:

1. Shoulder joint contructure
2. Forzen shoulder
3. Dizzness, lesion of auditory and vision.

Primary outcomes:
measure: Brief Pain Inventory - Short Form
timeFrame: Change from Baseline at 7 weeks
measure: Visual analogue scale
timeFrame: Change from Baseline at 7 weeks
Secondary outcomes:
measure: Wolf motor function test
timeFrame: Change from Baseline at 7 weeks
measure: Fugl-Meyer Assessment
timeFrame: Change from Baseline at 7 weeks
Other outcomes:
measure: Shoulder Pain Disability Index
timeFrame: Change from Baseline at 7 weeks
Locations:
city: Taipei
country: Taiwan
facility: Taipei Veterans General Hospital
state: Beitou
Study officials:
References:
Clinical trial NCT03951506: Multi-modal Exercise Program in Older Aduls With Knee Osteoarthritis
Official title: Effects a Multi-modal Exercise Program in Older Aduls With Knee Osteoarthritis
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Osteo Arthritis Knee
Lead sponsor: Cardenal Herrera University
Sponsor class: OTHER
First posted: 2019-05-15
Enrollment: 66
Sex: ALL
Minimum age (years): 60
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: Aim: To evaluate the short-term effects of a multi-modal exercise program on physical performance variables in older adults with knee osteoarthritis.

Detailed description: * Aim: To evaluate the short-term effects of 16 week multi-modal exercise program on physical performance variables in independent community-dwelling older adults with knee osteoarthritis.
* Design: randomized controlled trial.
* Setting: home-based intervention.

Eligibility criteria: Inclusion Criteria:

* Age ≥ 60 years
* Knee pain
* Score in Kellgren-Lawrence Scale ≥1

Exclusion Criteria:

* Unable to ambulate independently
* Mini-mental state examination score \< 24
* Barthel Index score \< 80
* Unstable cardiovascular disease
* Neurological disorder that could compromise exercising
* Upper or lower-extremity fracture in the past year

Primary outcomes:
measure: Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC)
timeFrame: 16 weeks
Secondary outcomes:
measure: Numeric pain Rating Scale (NRS)
timeFrame: 16 weeks
measure: Timed 10-Meter Walk Test (10-MWT)
timeFrame: 16 weeks
measure: 6-Minute Walk Test (6-MWT)
timeFrame: 16 weeks
Other outcomes:
Locations:
city: Moncada
country: Spain
facility: Universidad CEU Cardenal Herrera
state: Valencia
Study officials:
affiliation: Cardenal Herrera University
name: JF Lisón, PhD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT01111006: The Effect of Electronic Cleansing Toilet System (Bidet) on Anal Resting Pressure
Official title: The Effect of Electronic Cleansing Toilet System (Bidet) on Anal Resting Pressure in Normal Healthy Volunteers
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: EARLY_PHASE1
Conditions: Anorectal Physiology
Keywords: Electronic toilet
Bidet
Anorectal resting pressure
Lead sponsor: Seoul National University Hospital
Sponsor class: OTHER
Collaborators: name: Woongjin Coway Corporation
First posted: 2010-04-27
Enrollment: 20
Sex: ALL
Minimum age (years): 20
Maximum age (years): 30
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: SUPPORTIVE_CARE

Brief summary: The purpose of this study was to evaluate the effect of Bidet on anal resting pressure with regards to various flow rates and temperatures.

Detailed description: Bidet is an electronic device spraying stream of the water for cleansing the anus and sometimes to aid defecation. It is widely used in Korea and Japan, with the flow rate (pressure) and temperature of water varying widely among the manufacturers. However, the effects of Bidet on anorectal function have not been studied in detail with regards to these variables.

Eligibility criteria: Inclusion Criteria:

* healthy volunteer

Exclusion Criteria:

* anal disease pregnancy any medical disease that is necessary to treat psychosis

Primary outcomes:
measure: The pressure before and after applying the bidet
timeFrame: after 1minute
Secondary outcomes:
measure: The temperature of rectum
timeFrame: after 1minute
Other outcomes:
Locations:
city: Seoul
country: Korea, Republic of
facility: Department of Surgery, Seoul National University Hospital
Study officials:
affiliation: Department of Surgery, Seoul National University Hospital
name: Kyu Joo Park, MD, PhD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT00870506: Community Trial to Enhance Organ Donation
Official title: Community-based Intervention to Enhance Signing of Organ Donor Cards
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Tissue and Organ Procurement
Health Behavior
Keywords: Randomized Controlled Trial
Healthcare Disparities
Lead sponsor: Case Western Reserve University
Sponsor class: OTHER
Collaborators: name: Robert Wood Johnson Foundation
First posted: 2009-03-27
Enrollment: 973
Sex: ALL
Minimum age (years): 15
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL

Brief summary: The purpose of this study is to determine the effect of a 5-minute video intervention regarding organ donation and transplantation on increasing the number of organ donor cards signed in Northeastern Ohio Bureau of Motor Vehicles (OBMV) branches and on willingness to donate organs while living. The investigators hypothesize that persons in the intervention group will sign more donor cards and be more willing to donate organs while living than persons in the control group.

Detailed description: We propose a community-based randomized controlled trial involving 450 intervention and 450 control patrons visiting Ohio Bureau of Motor Vehicle branches (OBMV) to obtain a driver's license. Interventions patrons will watch a 5-minute video prior to entering the OBMV. Study personnel will interview intervention and control patrons after they leave the OBMV to determine whether they signed an organ donor card. We will also determine the effect of the video intervention on willingness to donate organs while living.

Eligibility criteria: Inclusion Criteria:

* English speaking
* Applying for driver's license, driver's permit or state id

Exclusion Criteria:

* Non-English speaking
* Persons who have already signed donor card

Primary outcomes:
measure: Proportion of signed donor cards
timeFrame: One day
Secondary outcomes:
measure: Proportion of participants willing to donate organs while living
timeFrame: One Day
Other outcomes:
Locations:
city: Cleveland
country: United States
facility: Ohio Bureau of Motor Vehicles
state: Ohio
Study officials:
affiliation: Case Western Reserve University
name: John D Thornton, MD, MPH
role: PRINCIPAL_INVESTIGATOR
References:
citation: Thornton JD, Alejandro-Rodriguez M, Leon JB, Albert JM, Baldeon EL, De Jesus LM, Gallardo A, Hossain S, Perez EA, Martin JY, Lasalvia S, Wong KA, Allen MD, Robinson M, Heald C, Bowen G, Sehgal AR. Effect of an iPod video intervention on consent to donate organs: a randomized trial. Ann Intern Med. 2012 Apr 3;156(7):483-90. doi: 10.7326/0003-4819-156-7-201204030-00004.
Clinical trial NCT01725399: Does First Oral Intake After Emergence Predict the Incidence of Post-operative Vomiting in Children?
Official title: Randomized Controlled Trial: Does First Oral Intake After Emergence From Anesthesia Predict the Incidence of Post-operative Vomiting in Children?
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Post-operative Vomiting
Keywords: post-operative vomiting
Lead sponsor: University of North Carolina, Chapel Hill
Sponsor class: OTHER
First posted: 2012-11-12
Enrollment: 183
Sex: ALL
Minimum age (years): 2
Maximum age (years): 18
Standard ages: CHILD
ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: SINGLE_GROUP
Primary purpose: PREVENTION

Brief summary: Second only to pain, nausea and vomiting are the most uncomfortable complications of surgery and anesthesia. Unfortunately, our best defense against post-operative nausea and vomiting, a medicine called ondansetron (Zofran), is in dire national shortage. Consequently, non-pharmacological methods of prevention and treatment for post-operative nausea and vomiting have increased import. Following emergence from general anesthesia, children often request food and drink. There have been no studies to date that definitively determine the optimal first food or drink choice for these children. This study proposes to randomize children to either water or juice first intake following surgery. The investigators expect to find that children who consume glucose are less likely to vomit than those who first receive water.


Eligibility criteria: Inclusion Criteria:

* Dental surgery
* Tonsillectomy and adenoidectomy
* Strabismus surgery
* Age 2-18

Exclusion Criteria:

* Patient refusal
* Parent refusal
* Allergy / contraindication to ondansetron
* Prone to vomiting
* Inpatient
* Preoperative anxiolysis with ketamine
* Recovery location other than PACU
* Nil per os at baseline
* Presence of enteric tube
* Contraindication to any part of the study protocol

Primary outcomes:
measure: Post-operative Vomiting
timeFrame: 24 hr post-op
Secondary outcomes:
Other outcomes:
Locations:
city: Chapel Hill
country: United States
facility: UNC Chapel Hill
state: North Carolina
Study officials:
affiliation: UNC Chapel Hill
name: Jamie R Wingate, MD
role: PRINCIPAL_INVESTIGATOR
affiliation: UNC Chapel Hill
name: Peggy P McNaull, MD
role: STUDY_CHAIR
References:
Clinical trial NCT04483999: Turkish Validity and Reliability Study of Virtual Reality Sickness Questionnaire
Official title: Turkish Validity and Reliability Study of Virtual Reality Sickness Questionnaire
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Sickness Behavior
Keywords: virtual reality
sickness
validity
reliability
turkish
Lead sponsor: Hacettepe University
Sponsor class: OTHER
First posted: 2020-07-23
Enrollment: 100
Sex: ALL
Minimum age (years): 18
Maximum age (years): 30
Standard ages: ADULT
Accepts healthy volunteers: yes
Observational model: CASE_ONLY
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: Healthy people

Brief summary: This study is planned for the cultural adaptation and validity of the "Virtual Reality Sickness Questionnaire".

Detailed description: Virtual reality (SG) creates a virtual environment that reflects a real environment and offers various experiences to users. Motion sickness can be observed in people after using virtual reality applications or simulation devices in education. There are questionnaires in the literature such as "Simulator Sickness Questionnaire" and "Motion Sickness Questionnaire". However, these questionnaires are specific surveys to evaluate symptoms that develop after vehicle handling or use of simulation devices for pilot training, while they are not ideal questionnaires to evaluate symptoms that may develop after virtual reality applications. Because there are important differences between virtual reality systems and simulation systems in terms of the appearance of motion disturbance symptoms. For this reason, "Virtual Reality Sickness Questionnaire" has been developed that can evaluate these symptoms.

There is no Turkish version of the "Virtual Reality Sickness Questionnaire" in the literature. For this reason, this study is planned for the cultural adaptation and validity of the "Virtual Reality Sickness Questionnaire".

Eligibility criteria: Inclusion Criteria:

* Not having mental - cognitive problems,
* Being a volunteer

Exclusion Criteria:

* Oculomotor and vestibular disease
* Cardiovascular, neurological and gastrointestinal problems

Primary outcomes:
measure: Virtual Reality Sickness Questionnaire
timeFrame: Change from Baseline sickness after 1 hour later.
measure: graybiel scale
timeFrame: Change from Baseline sickness after 1 hour later.
Secondary outcomes:
measure: international physical activity questionnaire
timeFrame: All of the participants will assess at baseline with this scale.
measure: tampa kinesiophobia scale
timeFrame: All of the participants will assess at baseline with this scale.
Other outcomes:
Locations:
city: Ankara
country: Turkey
facility: Hatice Çetin
state: Sıhhiye
Study officials:
affiliation: Hacettepe University
name: NEZİRE KOSE
role: PRINCIPAL_INVESTIGATOR
References:
citation: Kim HK, Park J, Choi Y, Choe M. Virtual reality sickness questionnaire (VRSQ): Motion sickness measurement index in a virtual reality environment. Appl Ergon. 2018 May;69:66-73. doi: 10.1016/j.apergo.2017.12.016. Epub 2018 Jan 16.
Clinical trial NCT00690599: Socioeconomic Profile and Patient Satisfaction Assessment
Official title: Socioeconomic Profile and Patient Satisfaction Assessment in an Academic Dental General Clinic
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Satisfaction
Dentist-Patient Relations
Keywords: Patient satisfaction
Dentist-Patient relations
Answering services
Lead sponsor: Fortaleza University
Sponsor class: OTHER
First posted: 2008-06-04
Enrollment: 80
Sex: ALL
Minimum age (years): 18
Maximum age (years): 70
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Time perspective: RETROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: Patients assisted in the general dental practice clinic at UNIFOR Ceará - Brazil.

Brief summary: The aim of the study was to evaluate the socioeconomic patient's profile and their level of satisfaction in the general dental practice clinic. A cross-sectional quantitative study was accomplished with 80 patients assisted at the referred service. A solely-applied questionnaire was used regarding the following aspects: structure and environment, fear and anxiety, reliability, empathy and commitment, resolutivity and quality of the accomplished services. It was observed that the assisted patients' profile consisted predominantly of a female sample (71,2%), that completed the medium learning (31,2%) and/or that didn't finish the fundamental level (26,2%). Moreover 50% of them presented a family income of 1 to 2 minimum salaries and 41,2% were unemployed. As the quality of the rendered technical service, nearly 70% of the users considered it great, as well as the clinic's structure and environment. Regarding the satisfaction with to the received treatment, 76,2% of the interviewees gave the maximum score of 10 and 95% would recommend the attendance to others. It is concluded that the patients are satisfied with the clinical attendance accomplished by the students in the general practice dental clinic at UNIFOR, in what refers to its technical and functional quality.


Eligibility criteria: Inclusion Criteria:

* Patient registered in Academic of Information System (SIA),
* Patient assisted in the general dental clinic,
* To have 18 years or more or to be parents accompanied,
* Agree with research participation.

Exclusion Criteria:

* To be urgency patient,
* To be the first day of attendance at clinic.

Primary outcomes:
Secondary outcomes:
Other outcomes:
Locations:
city: Fortaleza
country: Brazil
facility: Fortaleza University
state: Ceará
Study officials:
affiliation: Fortaleza University
name: Solange K Saito, PhD
role: PRINCIPAL_INVESTIGATOR
References: