Clinical trial NCT06480747: Strength Training and Muscle Lipids
Official title: The Effects of Strength Training on Neuromuscular Function and Muscle Lipids.
Study type: INTERVENTIONAL
Overall status: RECRUITING
Phase: NA
Conditions: Healthy
Keywords: exercise
muscle cross-sectional area
intramyocellular lipids
extramyocellular lipids
muscle power
motor unit
Lead sponsor: University of Kansas Medical Center
Sponsor class: OTHER
Collaborators: name: National Strength and Conditioning Association
First posted: 2024-06-28
Enrollment: 30
Sex: ALL
Minimum age (years): 8
Maximum age (years): 10
Standard ages: CHILD
Accepts healthy volunteers: yes
Allocation: NON_RANDOMIZED
Intervention model: PARALLEL
Primary purpose: BASIC_SCIENCE

Brief summary: The purpose of this study is examine the effects of 8 weeks (3 days/week) of resistance exercise training in children 8 to 10 years of age on muscle strength and power, motor unit activation, and lipid profiles of the vastus lateralis.


Eligibility criteria: Inclusion Criteria:

* Healthy volunteer males and females ages 8 - 10 years.

Exclusion Criteria:

* No history or ongoing neuromuscular diseases.
* No history or ongoing musculoskeletal injuries.
* No history or ongoing disease that effects metabolism.

Primary outcomes:
measure: Change in muscular power of the leg extensors, as measured with isokinetic strength testing.
timeFrame: Baseline, following the intervention (9 weeks)
Secondary outcomes:
measure: Change from baseline in thigh muscle cross-sectional area
timeFrame: Baseline, following the intervention (9 weeks)
Other outcomes:
measure: Change from baseline in intramyocellular lipids of the vastus lateralis, as measure with magnetic resonance spectroscopy
timeFrame: baseline, following the intervention (9 weeks)
measure: Change from baseline in extramyocellular lipids of the vastus lateralis, as measure with magnetic resonance spectroscopy
timeFrame: baseline, following the intervention (9 weeks)
measure: Change from baseline in the fatty acid saturation levels of the extramyocellular lipids of the vastus lateralis, as measure with magnetic resonance spectroscopy
timeFrame: baseline, following the intervention (9 weeks)
measure: Change from baseline in the fatty acid saturation levels of the intramyocellular lipids of the vastus lateralis, as measure with magnetic resonance spectroscopy
timeFrame: baseline, following the intervention (9 weeks)
measure: Change from baseline in motor unit activation, as measured with surface electromyography decomposition.
timeFrame: baseline, following the intervention (9 weeks)
measure: Change in total body lean mass, as measured with bioelectrical impedance analysis.
timeFrame: baseline, following the intervention (9 weeks)
measure: Change in total body fat mass, as measured with bioelectrical impedance analysis.
timeFrame: baseline, following the intervention (9 weeks)
Locations:
city: Kansas City
country: United States
facility: Hoglund Biomedical Imaging Center
state: Kansas
city: Lawrence
country: United States
facility: Neuromechanics Laboratory
state: Kansas
city: Overland Park
country: United States
facility: Exercise and Human Performance Laboratory
state: Kansas
city: Overland Park
country: United States
facility: Metabolic and Body Composition Laboratory
state: Kansas
Study officials:
References: