Clinical trial NCT05369247: Interval Versus Continuous Exercise During Pregnancy
Official title: Effects of Acute High-intensity Intervals Versus Moderate-intensity Continuous Cycling on Maternal and Fetal Health
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Pregnancy Related
Glucose, Low Blood
Fetal Heart Rate or Rhythm Abnormality Affecting Fetus
Fetal Blood Flow
Lead sponsor: University of Alberta
Sponsor class: OTHER
First posted: 2022-05-11
Enrollment: 32
Sex: FEMALE
Minimum age (years): 18
Maximum age (years): 50
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: CROSSOVER
Primary purpose: BASIC_SCIENCE

Brief summary: The objective of this randomized cross-over design was to investigate the fetal well-being and maternal glycemic response to an acute bout of aerobic high-intensity interval training (HIIT) and moderate-intensity continuous training (MICT) with pregnant individuals.


Eligibility criteria: Inclusion Criteria:

* Carrying a singleton pregnancy (i.e. greater than or equal to 20 weeks of gestation).
* Has access to a stationary bike
* Located within Canada and/or within Edmonton Alberta

Exclusion Criteria:

* History of smoking within the last year
* Taking medications that may interfere with cardiovascular function.
* High-order pregnancies, e.g. twins or above.
* Females with absolute contraindications (as outlined by the Canadian Guidelines for Physical Activity throughout Pregnancy and the PARMed-X questionnaire)

Primary outcomes:
measure: Flash Glucose Monitor; interstitial Glucose
timeFrame: 7-days
measure: Fetal Heart Rate
timeFrame: 3-minutes
measure: Fetal Umbilical Blood Flow
timeFrame: 3-minutes
Secondary outcomes:
measure: Maternal Heart Rate
timeFrame: 40-minutes
measure: Accelerometer
timeFrame: 7-days
measure: Food Log
timeFrame: 7-days
measure: Perceived rating of perceived exertion
timeFrame: 40-minutes
measure: Cardiovascular fitness
timeFrame: 20-minutes
measure: Cerebral Blood Flow of Posterior cerebral artery
timeFrame: 40-min
measure: Sleep Quality
timeFrame: 7-days
measure: Rating of Perceived Enjoyment (1-10 Scale)
timeFrame: 40-minutes
measure: Blood pressure
timeFrame: 40-min
measure: Cardiac Output
timeFrame: 40-min
measure: Cerebral blood flow of middle cerebral artery
timeFrame: 40-minutes
measure: fasted blood sample- sex hormones
timeFrame: 5-minutes
measure: Physical Activity Questionnaire
timeFrame: 5-minutes
measure: Depression rating
timeFrame: 5-minutes
measure: Respiratory measures - respiratory frequency
timeFrame: 40-minutes
measure: Respiratory measures - tidal volume
timeFrame: 40-minutes
measure: Respiratory measures - oxygen
timeFrame: 40-minutes
measure: Respiratory measures - carbon dioxide
timeFrame: 40-minutes
measure: Respiratory measures - lung volume
timeFrame: 40-minutes
measure: Fetal Outcome - birth weight
timeFrame: within one month postpartum
measure: fetal outcomes- length
timeFrame: within one month postpartum
measure: fetal outcomes- gestational age
timeFrame: within one month postpartum
measure: maternal outcomes- mode of delivery
timeFrame: within one month postpartum
measure: maternal outcomes- delivery complications
timeFrame: within one month postpartum
measure: maternal outcomes- pregnancy complications
timeFrame: any time during study
measure: fetal outcomes- NICU
timeFrame: within one month postpartum
measure: maternal outcomes- gestational weight gain
timeFrame: within one month postpartum
Other outcomes:
Locations:
city: Edmonton
country: Canada
facility: University of Alberta
state: Alberta
Study officials:
affiliation: University of Alberta
name: Margie H Davenport, PhD
role: PRINCIPAL_INVESTIGATOR
References: