Clinical trial NCT01624519: Agreement Between Arterial, Central Venous, and Peripheral Venous Lactate in the Intensive Care Unit
Official title: Agreement Between Arterial, Central Venous, and Peripheral Venous Lactate in the Intensive Care Unit
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Blood Lactate Analysis
Keywords: Arterial Lactate
Central Venous Lactate
Peripheral Venous Lactate
Lead sponsor: University of California, Los Angeles
Sponsor class: OTHER
Collaborators: name: Olive View-UCLA Education & Research Institute
First posted: 2012-06-20
Enrollment: 50
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: DIAGNOSTIC

Brief summary: The main objective of this study is to examine the agreement between arterial, central venous, and peripheral venous lactate values in a population of medical Intensive Care Unit (ICU) patients.

Detailed description: This study is a single-center, prospective trial to assess the agreement between arterial, central venous, and peripheral venous lactate measurements. When an arterial lactate is deemed to be necessary as part of ICU management, a central venous and peripheral venous sample will also obtained within 5 minutes. All of the samples will be analyzed using the same analyzer as quickly as possible. A maximum of 10 paired arterial and venous lactate samples will be obtained per patient to prevent a single patient from dominating the data set. Additional data collected on a standardized data collection form will include primary diagnosis, intubation status, use of inotropic agents, hypotension (defined as a systolic blood pressure \< 90 mm Hg), ICU length of stay and mortality. The Bland-Altman method will be used to assess agreement between arterial (A), central venous(CV), and peripheral venous (PV) lactate measurements. Approximately 50 patients will be enrolled in this study.

Eligibility criteria: Inclusion Criteria:

* Adult patients 18 years or older
* Admitted to the Intensive Care Unit (ICU)
* Determined by their treating clinicians to require both a central venous line and arterial line

Exclusion Criteria:

* None

Primary outcomes:
measure: Agreement between peripheral venous, central venous, and arterial lactate values in a population of medical Intensive Care Unit (ICU) patients.
timeFrame: 1 year
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
affiliation: Olive View-UCLA
name: Rick Treger
role: PRINCIPAL_INVESTIGATOR
References:
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