Clinical trial NCT04582253: Pix2pix Networks for Scheimpflug Corneal Tomography Image Generation
Official title: Pix2pix Conditional Generative Adversarial Networks for Scheimpflug Camera Color-coded Corneal Tomography Image Generation
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Eye Diseases
Keywords: Cornea
Imaging
Lead sponsor: Assiut University
Sponsor class: OTHER
First posted: 2020-10-09
Enrollment: 923
Sex: ALL
Minimum age (years): 18
Maximum age (years): 50
Standard ages: ADULT
Accepts healthy volunteers: yes
Observational model: COHORT
Time perspective: RETROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Refractive surgery candidates with unilateral, bilateral, or forme fruste keratoconus, obtained between July 2014 and March 2019 at private eye center, Assiut, Egypt.

Brief summary: Computer-aided medical image analysis has advantages, but requires large amounts of training data, which are scarce and costly to obtain, are subject to privacy concerns, and are often highly imbalanced, with over-representation of common conditions and poor representation of rare conditions. Consequently, some methods have been proposed to generate artificial medical images using generative adversarial networks (GANs). Computer aided diagnosis of keratoconus is an emerging research field that may benefit greatly from medical image synthesis, which can affordably provide an arbitrary number of sufficiently diverse synthetic images that mimic real Pentacam images. A new conditional GAN, the pix2pix cGAN, has not been used in this context to date. Here, investigators will assess the efficacy of a cGAN implementing pix2pix image translation for image synthesis of color-coded Pentacam 4-map refractive displays of clinical and subclinical keratoconus as well as normal corneas.


Eligibility criteria: Inclusion Criteria:

* Keratoconus group:

  * Presence of a central protrusion of the cornea with Fleischer ring, Vogt striae, or both by slitlamp examination.
  * irregular cornea determined by distorted keratometry mires and distortion of retinoscopic red reflex or both in addition to the following topographic findings as summarized by Pińero and colleagues :
  * focal steepening located in a zone of protrusion surrounded by concentrically decreasing power zones
  * focal areas with dioptric (D) values \>47.0D
  * inferior- superior(I-S) asymmetry measured to be \> 1.4 D
  * Angling of the hemimeridians in an asymmetric or broken bowtie pattern with skewing of the steepest radial axis(SRAX) .

Suspicious group:

• Defined as subtle corneal tomographic changes as the aforementioned keratoconus abnormalities in the absence of slit- lamp or visual acuity changes typical of keratoconus (forme fruste keratoconus).

Normal group:

* Refractive surgery candidates
* Refractive error of less than 8.0 D sphere
* Less than 3.0 D of astigmatism
* without clinical, topographic or tomographic signs of keratoconus or suspect keratoconus.

Exclusion Criteria:

* • Systemic disease

  * Other corneal disease such as pellucid marginal degeneration
  * History of trauma
  * Corneal surgery such as corneal cross- linking for progressive keratoconus.

Primary outcomes:
measure: Scheimpflug camera color-coded corneal tomography images created by pix2pix conditional adversarial network (pix2pix cGAN)
timeFrame: 1 day
Secondary outcomes:
Other outcomes:
Locations:
city: Assiut
country: Egypt
facility: Faculty of Medicine
Study officials:
References: