louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT01250899: Vitamin D in HIV-Infected Patients on HAART
Official title: Vitamin D, Immune Activation, and Metabolic Abnormalities in HIV-Infected Patients on Antiretroviral Therapy
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Vitamin D Deficiency
HIV
Keywords: HIV
Vitamin D
HAART
Lead sponsor: University of California, Los Angeles
Sponsor class: OTHER
First posted: 2010-12-01
Enrollment: 122
Sex: ALL
Minimum age (years): 18
Maximum age (years): 90
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NON_RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: This is a research study to look at vitamin D deficiency (low levels) in men and women with HIV. As part of your regular medical care, you will be screened for vitamin D deficiency. If your levels are low, and you choose to start using vitamin D supplements, the investigators would like to take some blood before and after you start using vitamin D to see how this affects your levels of HIV, T cells, cholesterol, and other blood levels. The investigators will provide you with vitamin D supplements for the first 24 weeks (6 months) of the study. If you and your physician decide that you should continue taking vitamin D supplements after that time, you will be responsible for purchasing your own vitamin D supplements.


Eligibility criteria: Inclusion Criteria:

* HIV-positive men and women age 18 and older.
* HIV-1 RNA documented to be \< 200 copies/mL on their current ART regimen, with supporting viral load documentation in the 24 weeks prior to study entry.
* Subjects must receive primary HIV care at the UCLA CARE center.
* Subjects must be undergoing screening for vitamin D deficiency by their primary care provider at the time of study entry, or have undergone vitamin D screening in the 90 days prior to consent without yet initiating vitamin D supplementation (for insufficient subjects).
* Ability and willingness of subject to provide informed consent

Exclusion Criteria:

* Use of vitamin D supplementation (not including 400 IU daily, the amount in a standard multivitamin) at the time of screening.
* HIV-infected subjects not on ART.
* HIV-infected subjects not suppressed on their current ART regimen (HIV-1 RNA \> 200 copies/mL in the 6 months prior to screening).

Primary outcomes:
measure: Success Rate in Achieving a 25(OH)D Level ≥30ng/mL After 12 Weeks of Oral Vitamin D Supplementation.
timeFrame: 12 weeks
Secondary outcomes:
Other outcomes:
Locations:
city: Los Angeles
country: United States
facility: UCLA CARE Center
state: California
Study officials:
affiliation: University of California, Los Angeles
name: Judith Currier, M.D.
role: STUDY_DIRECTOR
affiliation: University of California, Los Angeles
name: Jordan Lake, M.D.
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT04213599: The Angiography Characteristic of Free Wall Ruptrue in STEMI
Official title: The Coronary Angiography Characteristic of Free Wall Ruptrue in ST-Elevation Myocardial Infarction Patients
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: ST-Elevation Myocardial Infarction
Keywords: STEMI
Ruptrue
Angiography
Lead sponsor: Xiamen Cardiovascular Hospital, Xiamen University
Sponsor class: OTHER
First posted: 2019-12-30
Enrollment: 14629
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: STEMI patients anticipated to undergo angiography

Brief summary: To analyze whether the location of myocardial infarction and infarct related artery are related to FWR.

Detailed description: To know the characteristic of FWR that different location of STEMI and coronary distribution

Eligibility criteria: Inclusion Criteria:

1. Patients had to be ≥18 years of age, be admitted for STEMI
2. Accord with STEMI diagnostic criteria
3. STEMI patients anticipated to undergo angiography

Exclusion Criteria:

1. Pregnant
2. Acute stroke
3. Aortic dissection

Primary outcomes:
measure: Number of cardiac death
timeFrame: 30 days
measure: Number of free-wall rupture
timeFrame: 30 days
measure: Number of reperfusion arrhythmia
timeFrame: 30 days
Secondary outcomes:
measure: FMC time
timeFrame: 30 days
measure: Symptom onset to angiology time
timeFrame: 30 days
Other outcomes:
Locations:
city: Xiamen
country: China
facility: Xiamen Cardiovascular Hospital Xiamen University
state: Fujian
Study officials:
affiliation: Xiamen Cardiovascular Hospital, Xiamen University
name: Bin Wang, PhD
role: STUDY_DIRECTOR
References:
Clinical trial NCT01111799: Does Local Injury of the Endometrium Improve Controlled Ovarian Hyperstimulation (COH) + Intrauterine Insemination (IUI) Outcome?
Official title: Exploration of the Possibility That Local Injury of the Endometrium Has the Same Beneficial Effect on IUI Outcome as Demonstrated in IVF Treatment
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Infertility
Implantation Failure
Keywords: endometrial biopsy
implantation
uterine receptivity
infertility
controled ovarian hyperstimulation
intra uterine insemination
Lead sponsor: Meir Medical Center
Sponsor class: OTHER
First posted: 2010-04-28
Enrollment: 600
Sex: FEMALE
Minimum age (years): 18
Maximum age (years): 38
Standard ages: ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: It was previously demonstrated in in vitro fertilization (IVF) patients that local injury of the endometrium during a spontaneous menstrual cycle that precedes IVF treatment doubled the rates of implantation and pregnancy. The hypothesis of our present study is that the endometrial injury procedure will have the same beneficial effect in patients undergoing controlled ovarian hyperstimulation (COH) combined with intrauterine insemination (IUI).

Detailed description: In order to test our hypothesis, we will perform the simple procedure of local injury of the endometrium using a "Pipelle" biopsy catheter during the spontaneous menstrual cycle that precedes a COH + IUI treatment.

Eligibility criteria: Inclusion Criteria:

* age 18-38.
* infertility.
* patients undergoing IUI treatment.
* at least one failed IUI cycle.

Exclusion Criteria:

* indication for IVF treatment.
* Known Pelvic inflammatory disease(PID).

Primary outcomes:
measure: Clinical Pregnancy rate
timeFrame: 1 year
Secondary outcomes:
measure: Live birth
timeFrame: 2 years
Other outcomes:
Locations:
city: Rehovot
country: Israel
facility: Remez women medical center
Study officials:
affiliation: Clalit health service
name: Yuval Or, MD
role: STUDY_DIRECTOR
References:
citation: Barash A, Dekel N, Fieldust S, Segal I, Schechtman E, Granot I. Local injury to the endometrium doubles the incidence of successful pregnancies in patients undergoing in vitro fertilization. Fertil Steril. 2003 Jun;79(6):1317-22. doi: 10.1016/s0015-0282(03)00345-5.
Clinical trial NCT05317299: Comparison of the Effects of Different Exercise Types
Official title: Comparison of the Effects of Different Exercise Types on Lower Extremity Muscle Thickness, Tendon Thickness, Muscle Strength, Proprioception and Balance
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Healthy
Keywords: muscle structure
muscle thickness
joint position sense
postural stability
Lead sponsor: Muğla Sıtkı Koçman University
Sponsor class: OTHER
Collaborators: name: Muğla Sıtkı Koçman University
First posted: 2022-04-07
Enrollment: 65
Sex: MALE
Minimum age (years): 18
Maximum age (years): 30
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Intervention model description: Randomized 3 exercise group (RE, PE and HIIT)
Primary purpose: OTHER

Brief summary: This study perform to investigate the comparison of the effects of different exercise types on lower extremity muscle thickness, tendon thickness, muscle strength, proprioception and balance.

Detailed description: The choice of exercise type is affected by many different factors. The purpose of exercise and the physical fitness parameter they want to develop gain importance in this choice.

Resistance exercises (RE) specifically designed to increase muscle strength and hypertrophy; Plyometric exercises (PE) based on energy storage of the muscle during the deceleration phase and release of this energy during the acceleration period and high-intensity interval training (HIIT), which is an advanced form of interval training that includes shorter and lighter recovery periods following short to heavy anaerobic exercise are some of the many types of exercises in the literature and practice.

The purpose of the study is investigate the comparison of the effects of different exercise types on lower extremity muscle thickness, tendon thickness, muscle strength, proprioception and balance.

Eligibility criteria: Inclusion Criteria:

1. Being 18-30 years old
2. Being a man
3. Volunteering to participate in the study
4. Having a normal BMI (18.5-24.9) according to the World Health Organization criteria

Exclusion Criteria:

1. Having any physical, mental or psychological illness that may affect participation in the study
2. Having a history of trauma to the lower extremity requiring medical, conservative and surgical treatment in the last 6 months
3. Consuming alcohol or pharmaceuticals up to 24 hours before the assessment

Primary outcomes:
measure: Muscle Thickness assessment with B-mode Ultrasonography
timeFrame: 8 weeks
measure: Tendon Thickness assessment with B-mode Ultrasonography
timeFrame: 8 weeks
measure: Muscle Strength assessment with manual dinamometer
timeFrame: 8 weeks
measure: Joint position sense assessment with angle repetition test
timeFrame: 8 weeks
measure: a kinesthetic ability trainer (Sport KAT Model 650-TS)
timeFrame: 8 weeks
Secondary outcomes:
Other outcomes:
Locations:
city: Muğla
country: Turkey
facility: Mugla Sıtkı Koçman University
Study officials:
References:
Clinical trial NCT05471999: Retrospective Analysis on Small Bowel Perforations
Official title: Small Bowel Perforations: Etiology, Treatment and Outcome
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Small Bowel Perforations
Lead sponsor: University Hospital Tuebingen
Sponsor class: OTHER
First posted: 2022-07-25
Enrollment: 270
Sex: ALL
Minimum age (years): 18
Maximum age (years): 99
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Intervention model description: Retrospective data analysis
Primary purpose: TREATMENT

Brief summary: A retrospective, monocentric, code-related data analysis of patients with small bowel perforations was performed for the period 2010 to 2019.

Detailed description: Analyzed parameters were etiology and timing of perforation, associated morbidity and mortality, type of therapy and its success, and long-term consequences for patients, such as the development of short bowel syndrome.

Eligibility criteria: Inclusion Criteria:

* small bowel perforation in adults

Exclusion Criteria:

* age \< 18 years

Primary outcomes:
measure: mortality rate
timeFrame: 30 days
Secondary outcomes:
measure: Small bowel syndrome
timeFrame: 30 days
Other outcomes:
Locations:
city: Tuebingen
country: Germany
facility: University Hospital of Tuebingen
Study officials:
affiliation: Zentrum für klinische Studien der UNiversitätsklinik Tübingen
name: S. Bethge, Prof. Dr.
role: STUDY_CHAIR
References:
Clinical trial NCT03313999: Measuring Skin Elasticity in Lymphedema Patients
Official title: Measuring Skin Elasticity in Lymphedema Patients
Study type: INTERVENTIONAL
Overall status: TERMINATED
Phase: NA
Conditions: Diagnoses Disease
Lymphedema
Keywords: Lymphedema indentometer
Durometer
Lead sponsor: Beth Israel Deaconess Medical Center
Sponsor class: OTHER
First posted: 2017-10-19
Enrollment: 7
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: DIAGNOSTIC

Brief summary: This protocol will utilize the lymphedema indentometer, or durometer (a novel, noninvasive piece of equipment that measures skin elasticity), to better characterize disease progression in patients with lymphedema. Beth Israel Deaconess Medical Center patients who undergo treatment of lymphedema will be candidates for this noninvasive test. This device and the data it generates will help understand the incidence of lymphedema at Beth Israel Deaconess Medical Center compared to national data and the outcomes of surgical treatment of lymphedema.


Eligibility criteria: Inclusion Criteria:

* Patients evaluated by the Beth Israel Deaconess Medical Center Lymphedema team with a diagnosis of lymphedema OR determined to be at risk of developing Lymphedema in any of their extremities
* Patients must be over 18 years of age
* Patients must be willing and capable to provide informed consent
* Patients must speak English

Exclusion Criteria:

* None

Primary outcomes:
measure: Durometer Measurement
timeFrame: Enrollment (3 years)
Secondary outcomes:
Other outcomes:
Locations:
city: Boston
country: United States
facility: Beth Israel Deaconess Medical Center
state: Massachusetts
Study officials:
affiliation: Beth Israel Deaconess Medical Center
name: Dhruv Singhal, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT01258699: A Study Comparing the Pharmacokinetics of BK-C-0701 320mg, 480mg and Thiocacid HR Tab 600mg in Healthy Adult Male Subjects
Official title: A Study Comparing the Pharmacokinetics of BK-C-0701 320mg, 480mg and Thiocacid HR Tab 600mg in Healthy Adult Male Subjects
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE1
Conditions: Healthy Adult Male
Lead sponsor: Bukwang Pharmaceutical
Sponsor class: INDUSTRY
First posted: 2010-12-13
Enrollment: 30
Sex: MALE
Minimum age (years): 20
Maximum age (years): 45
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: This study is Comparing the Pharmacokinetics of BK-C-0701 320mg, 480mg and Thiocacid HR Tab 600mg in Healthy Adult Male Subjects.


Eligibility criteria: Inclusion Criteria:

* Male is between 20 and 45
* Weight is between 50 and 90kg, and in 20% of ideal weight. Ideal weight(kg)=(height(cm)-100)\*0.9
* Medical history, physical examination, ECG and laboratory test are suitable to the study if judged by an investigator.
* Patient is willing to use an effective method of contraception during the study and for up to 1 months after the use of study drug ceases. (Effective method=spermicide with condom)
* Subject is able to give written informed consent prior to study start and to comply with the study requirements.

Exclusion Criteria:

* Patient received drug affected to the study within 14 days from the study initiation.
* Patient received drug-metbolizing enzyme inducer or inhibitor such as Barbiturates within 1 month from the study initiation.
* Subject is hypersensitive investigational drug(Thioctic acid).
* Patient with gastrointestinal history affected absorbing investigational drug or inhibiting normal gastrointestinal motility, gastrointestinal operation or gastrointestinal wound.
* Patient with renal, hepatic, bronchopulmonary, cardiovascular, gastrointestinal, metabolic, neurological, psychotic, oncologic, allergic disease, myocardial infarction, cardiac crisis, hepatitis or pancreatitis history.
* ECG is abnormal.
* Patient abused drug.
* Patient joined other clinical study within 3 months from the study initiation.
* Patient doanted whole blood within 2 months or plasma blood within 1 month from the first medication.
* HBsAg, HCV Ab or HIV Ab are positive.
* Patient who was not suitable to the study if judged by an investigator.

Primary outcomes:
Secondary outcomes:
Other outcomes:
Locations:
city: Seoul
country: Korea, Republic of
facility: Seoul National University Hospital
Study officials:
References:
Clinical trial NCT06788899: Clinical Audit on Uterine Closure During Caesarean Section in Assiut Women's Health Hospital
Official title: Clinical Audit on Uterine Closure During Caesarean Section in Assiut Women's Health Hospital
Study type: OBSERVATIONAL
Overall status: NOT_YET_RECRUITING
Conditions: Uterine Closure in Caesarean Section
Lead sponsor: Assiut University
Sponsor class: OTHER
First posted: 2025-01-23
Enrollment: 300
Sex: FEMALE
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: OTHER
Time perspective: OTHER
Sampling method: NON_PROBABILITY_SAMPLE
Study population: All elective Caeserean sections with no medical or obestetric disorder

Brief summary: Auditing of closure of uterine incision in Caesarean section in Assiut Women's Health Hospital.


Eligibility criteria: Inclusion Criteria:

* all elective Caesarean section

Exclusion Criteria:

1. Placenta previa
2. Chorioamionitis
3. PROM
4. Diabetic women
5. Immunocompromised women
6. Women with heart disease
7. Women with renal or liver disease
8. Women on corticosteroids therapy
9. Preeclampsia
10. Women with hypertensive disorders

Primary outcomes:
measure: Improve performance of closure of Caesarean section. in Assiut Women health hospital according to NICE guidelines and National Library of Medicine
timeFrame: Through study completion an average of one year
Secondary outcomes:
measure: Decrease complications of caeserean section
timeFrame: Through study completion an average of one year
measure: Training of university staff
timeFrame: Through study completion an average of one year
Other outcomes:
Locations:
Study officials:
References:
citation: Principles of Methodological Design of Clinical Audit. Arch Med Vol No:10 Iss No:2:2(1)
citation: 1-Morrell C and Harvey G (1999) The Clinical Audit Handbook. Improving the quality of health care. London: Bailliere Tindall.(1)
citation: Hauth JC, Owen J, Davis RO. Transverse uterine incision closure: one versus two layers. Am J Obstet Gynecol. 1992 Oct;167(4 Pt 1):1108-11. doi: 10.1016/s0002-9378(12)80048-2.
Clinical trial NCT01477099: Toothbrushing and Ventilator-associated Pneumonia
Official title: Efficacy of Toothbrushing for the Prevention of Ventilator-associated Pneumonia
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE4
Conditions: Ventilator Associated Pneumonia
Lead sponsor: Hospital Universitario de Canarias
Sponsor class: OTHER
First posted: 2011-11-22
Enrollment: 436
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: PREVENTION

Brief summary: The hypothesis is that adding the toothbrushing to the oral care with clorhexidine 0.12% could be reduce the incidence of ventilator-associated pneumonia due to that oral cavity may be an important reservoir of pathogens that could cause pneumonia.


Eligibility criteria: Inclusion Criteria:

* mechanical ventilation

Exclusion Criteria:

* edentulous

Primary outcomes:
measure: Prevention of ventilator-associated pneumonia
timeFrame: 60 days
Secondary outcomes:
Other outcomes:
Locations:
city: La Laguna
country: Spain
facility: Leonardo Lorente
state: Tenerife
Study officials:
affiliation: Hospital Universitario de Canarias
name: Leonardo Lorente, Medical
role: PRINCIPAL_INVESTIGATOR
References:
citation: Lorente L, Lecuona M, Jimenez A, Palmero S, Pastor E, Lafuente N, Ramos MJ, Mora ML, Sierra A. Ventilator-associated pneumonia with or without toothbrushing: a randomized controlled trial. Eur J Clin Microbiol Infect Dis. 2012 Oct;31(10):2621-9. doi: 10.1007/s10096-012-1605-y. Epub 2012 Mar 16.
Clinical trial NCT04256499: Water Load Test Value for Hyponatremia
Official title: Water Load Test Value for Hyponatremia Due to a Syndrome of Inappropriate Antidiuresis (SIAD)
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: SIAD - Syndrome of Inappropriate Antidiuresis
Hyponatremia
Keywords: hyponatremia
SIAD
water load test
Lead sponsor: European Georges Pompidou Hospital
Sponsor class: OTHER
First posted: 2020-02-05
Enrollment: 150
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: RETROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: In this retrospective study, the included population is composed only with adult patients experiencing a syndrome of inappropriate antidiuresis (SIAD) who were explored by an acute water load test at the Renal and Metabolic Diseases Unit of the European George Pompidou Hospital, Paris, France.

Brief summary: Acute water load test has been using to diagnose renal ability to excrete water for decades. Latest recommendations for the diagnosis of hyponatremia do not recommend performing such a test. The investigators aim at, retrospectively, study the value of acute water load test in patients suffering from a syndrome of inappropriate antidiuresis.


Eligibility criteria: Inclusion Criteria:

* ≥ 18 years old at the time of the test
* affiliated to a social insurance system
* water load test performed at the Renal and Metabolic Diseases Unit of the European George Pompidou Hospital, AP-HP, Paris, France
* between 01/01/2001 and 12/31/2019

Exclusion Criteria:

* hypernatremia and/or polyuria-polydipsia (diabetes insipidus)
* hyponatremia due to a tea and toast syndrome and/or a beer potomania
* hyponatremia due to a high (or normal) osmolality related to diabetes mellitus, hyperproteinemia and/or intoxication
* chronic kidney disease with an estimated glomerular filtration rate (eGFR) by the MDRD formula \<60 mL/min/1.73m2
* hyponatremia related to thiazides
* hyponatremia related to an hypovolemic status
* syndrome of inappropriate antidiuresis related to an endocrine disorder (such as hypothyroidism or adrenal insufficiency)

Primary outcomes:
measure: Natremia
timeFrame: any time after water load test from hour 2 to hour 6
Secondary outcomes:
measure: Plasma osmolality
timeFrame: any time after water load test from hour 2 to hour 6
measure: Excretion of water load
timeFrame: after water load test from hour 0 to hour 6
measure: Urine osmolality
timeFrame: any time after water load test from hour 2 to hour 6
Other outcomes:
measure: Body weight
timeFrame: Value at hour 6 versus initial value (hour 0)
Locations:
city: Paris
country: France
facility: European Georges Pompidou Hospital, APHP
Study officials:
affiliation: Assistance Publique - Hôpitaux de Paris
name: Jean-Philippe Bertocchio, MD, PhD
role: PRINCIPAL_INVESTIGATOR
References: