Clinical trial NCT06562049: Carpal Bone Erosion in Rheumatoid Arthritis :Diagnostic Value
Official title: Carpal Bone Erosion in Rheumatoid Arthritis :Diagnostic Value
Study type: OBSERVATIONAL
Overall status: NOT_YET_RECRUITING
Conditions: Rheumatoid Arthritis
Lead sponsor: Sohag University
Sponsor class: OTHER
First posted: 2024-08-20
Enrollment: 110
Sex: ALL
Minimum age (years): 18
Maximum age (years): 75
Standard ages: ADULT
OLDER_ADULT
Observational model: OTHER
Time perspective: CROSS_SECTIONAL
Sampling method: PROBABILITY_SAMPLE
Study population: 1. RA patients fulfilled the 2010 American College of Rheumatoid Arthritis classification criteria.\[8\]
2. SLE patients fulfilled the 2019 ACR\\EULAR classification criteria for SLE.\[9\]
3. Age above 18 years old.
4. Patient cooperative and can answer questions.
5. Patients who are able and willing to give written informed consent

Brief summary: Rheumatoid arthritis (RA) is a systemic inflammatory disease characterized by proliferative hyper vascularized synovitis which primarily affects synovial joints. Synovium of bursa; tendon sheaths; attachment sites of cartilage, ligament, and tendons to the bone; soft tissue; and bones can be mentioned among the other areas under influence of RA. Changes happen to be symmetrical and may present as fusiform soft tissue swelling, regional osteoporosis, marginal-central erosions, cartilage damage, joint destruction, narrowing of joint space and fibrous ankyloses. Wrist, metacarpophalangeal and metatarsophalangeal joints are the first sites to be affected .Over the past few years, an increasing number of rheumatologists have started to use US in the clinical setting of the early arthritis clinic. While US allows for an accurate and non-invasive multisite assessment of joint involvement in patients with RA, time for US examination is not infinite


Eligibility criteria: Inclusion Criteria:

* 1. RA patients fulfilled the 2010 American College of Rheumatoid Arthritis classification criteria.\[8\] 2. SLE patients fulfilled the 2019 ACR\\EULAR classification criteria for SLE.\[9\] 3. Age above 18 years old. 4. Patient cooperative and can answer questions. 5. Patients who are able and willing to give written informed consent.

Exclusion Criteria:

* 1. Age below 18 years and above 60 years. 2. Uncooperative patients. 3. Patient not able and willing to give written informed consent.

Primary outcomes:
measure: bone erosion
timeFrame: max 1 year
Secondary outcomes:
Other outcomes:
Locations:
city: Sohag
country: Egypt
facility: Sohag University hospitals
Study officials:
References:
citation: Sommer OJ, Kladosek A, Weiler V, Czembirek H, Boeck M, Stiskal M. Rheumatoid arthritis: a practical guide to state-of-the-art imaging, image interpretation, and clinical implications. Radiographics. 2005 Mar-Apr;25(2):381-98. doi: 10.1148/rg.252045111.
citation: Ejbjerg BJ, Vestergaard A, Jacobsen S, Thomsen H, Ostergaard M. Conventional radiography requires a MRI-estimated bone volume loss of 20% to 30% to allow certain detection of bone erosions in rheumatoid arthritis metacarpophalangeal joints. Arthritis Res Ther. 2006;8(3):R59. doi: 10.1186/ar1919. Epub 2006 Mar 15.
citation: Mottonen TT. Prediction of erosiveness and rate of development of new erosions in early rheumatoid arthritis. Ann Rheum Dis. 1988 Aug;47(8):648-53. doi: 10.1136/ard.47.8.648.