Clinical trial NCT03871647: Effect of Genetic Polymorphism on the Occurrence of Post-Operative Atrial Fibrillation After CABG
Official title: Effect of Genetic Polymorphism on the Occurrence of Post-Operative Atrial Fibrillation After Coronory Artery Bypass Grafting (CABG) Surgery in Egyptian Patients Receiving Beta Blockers
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Coronary Bypass Graft Surgery
Atrial Fibrillation
Lead sponsor: Ain Shams University
Sponsor class: OTHER
Collaborators: name: Misr International University
First posted: 2019-03-12
Enrollment: 256
Sex: ALL
Minimum age (years): 18
Maximum age (years): 100
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Egyptian patients undergoing Coronary Artery Bypass grafting Surgery

Brief summary: Postoperative Atrial Fibrillation (POAF) is one of the most common complications following coronary artery bypass grafting (CABG) occurring to 20% - 40% of patients. It is associated with prolonged hospitalization, increased hospital costs, increased complications and mortality rate.

Despite the use of Beta Blockers, approximately 20% of patients develop atrial fibrillation following CABG surgery, suggesting a role for polymorphism in the genes The aim of the present study is to determine the minor allele frequency of some of the genes that affect the beta blockers' response and to determine the association between polymorphism in these genes and the occurrence of postoperative atrial fibrillation after coronary artery bypass grafting in Egyptian patients receiving perioperative beta blockers.


Eligibility criteria: Inclusion Criteria:

1. Age above 18 years.
2. Candidates for CABG surgery without a concurrent valve surgery.
3. Patients receiving perioperative beta blockers before new onset of postoperative AF.

Exclusion Criteria:

1. Patients who have either persistent or permanent AF, atrial flutter or atrial tachycardia on ECG obtained on the day of the operation.
2. Serum creatinine \>2 mg/dL before the surgery.
3. Uncontrolled thyroid disease.
4. Recent treatment with amiodarone before the occurrence of POAF

Primary outcomes:
measure: Occurrence of Atrial fibrillation
timeFrame: within 6 days after the operation
Secondary outcomes:
Other outcomes:
Locations:
city: Cairo
country: Egypt
facility: The Cardiovascular & Thoracic Academy - Ain Shams University.
Study officials:
affiliation: Misr Ineternational University
name: Dina M El Gindy, MSC
role: PRINCIPAL_INVESTIGATOR
affiliation: Ain Shams University
name: Lamiaa M ElWakeel, PhD
role: STUDY_CHAIR
affiliation: Misr International University
name: Mona F Schaalan, PhD
role: STUDY_DIRECTOR
affiliation: Ain Shams Uiversity
name: Ramy MR Khorshid, Md, PhD
role: STUDY_DIRECTOR
affiliation: Ain Sham University
name: Mohamed H Solayman, PhD
role: STUDY_DIRECTOR
References:
citation: El Gindy DMK, Solayman MH, Khorshid R, Schaalan MF, El Wakeel LM. Effect of Clinical and Genetic Factors on the Development of Postoperative Atrial Fibrillation After Coronary Artery Bypass Grafting (CABG) in Egyptian Patients Receiving Beta-Blockers. Cardiovasc Drugs Ther. 2024 Feb;38(1):99-108. doi: 10.1007/s10557-022-07380-6. Epub 2022 Sep 15.