Clinical trial NCT02538445: Can we Forget? Directed Forgetting and Embodied Cognition in Schizophrenia
Official title: Can we Forget? Directed Forgetting and Embodied Cognition in Schizophrenia
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Schizophrenia
Keywords: Schizophrenia
Memory
Cognition
Lead sponsor: Centre Hospitalier Universitaire de Saint Etienne
Sponsor class: OTHER
First posted: 2015-09-02
Enrollment: 96
Sex: ALL
Minimum age (years): 18
Maximum age (years): 50
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL

Brief summary: Based on the theory of embodied cognition, which focuses on the influence of sensory and motor processes on cognition, researchers propose to study the influence of the action on memorization and inhibition in patients suffering from schizophrenia, using a directed forgetting paradigm. The directed forgetting paradigm is used, composed of two lists of action verbs. The instruction "to forget" is given at the end of learning the first list (To Be Forgotten (TBF)), following a simulation of a computer bug. Therefore a second list is presented to be learned and remembered (To Be Remembered (TBR)). A recognition task is performed at the end. The action verbs had to be encoded using four conditions: action performed, mimed, imagined action, action with a contextual word, reading the action verb only. 48 schizophrenic patients were included in this study. Patients were randomized to have 10 participants per condition. 48 controls matched by age, gender, laterality and education are also included and randomized in the same modality. This study aims to show that the encoding of sensory-motor components, more than providing a context could improve the inhibitory capacities but also memory in schizophrenia, and possibly be used in remediation cognitive.

Detailed description: Researchers used the directed forgetting paradigm composed of two lists of action verbs. The instruction "to forget" is given at the end of learning the first list (To Be Forgotten (TBF)), following a simulation of a computer bug. Therefore a second list is presented to be learned and remembered (To Be Remembered (TBR)). A recognition task is performed at the end. The action verbs had to be encoded using four conditions: action performed, mimed, imagined action, action with a contextual word, reading the action verb only. 48 schizophrenic patients were included in this study. Patients were randomized to have 10 participants per condition. 48 controls matched by age, gender, laterality and education are also included and randomized in the same modality. This study aims to show that the encoding of sensory-motor components, more than providing a context could improve the inhibitory capacities but also memory in schizophrenia, and possibly be used in remediation cognitive.

Eligibility criteria: Inclusion Criteria for patients:

* Schizophrenic patients as defined in Diagnostic and Statistical Manual of Mental Disorders IV (DSM-IV)
* Stabilized a therapeutic point of view for at least one month.
* Consent form signed
* Affiliated to a Security Health Program

Inclusion Criteria for volunteers:

* Consent form signed
* Affiliated to a Security Health Program

Exclusion Criteria for patients and volunteers :

* Not having a history of head trauma, neurological disease or not stabilized serious somatic illness,
* Not to use psychoactive substance, as defined by the DSM IV.
* The Intelligence Quotient must not be less than 70 (Progressive Matrices Standard score (PM38), Raven Progressive Matrix).

Primary outcomes:
measure: Number of items recalled TBR and TBF
timeFrame: Day 1
Secondary outcomes:
measure: Number of recognized items
timeFrame: Day 1
measure: Reaction time (ms) on the recognition of TBR and TBF
timeFrame: Day 1
Other outcomes:
Locations:
city: Saint Etienne
country: France
facility: CHU de SAINT-ETIENNE
Study officials:
affiliation: CHU de Saint-Etienne
name: Anne GROSSELIN, MD
role: PRINCIPAL_INVESTIGATOR
References: