louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT04605237: Pancreatic Cancer Recurrence in the Netherlands
Official title: Detection, Treatment and Survival of Pancreatic Cancer Recurrence in the Netherlands
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Pancreatic Ductal Adenocarcinoma
Pancreatic Cancer
Pancreas Cancer
PDAC
Lead sponsor: UMC Utrecht
Sponsor class: OTHER
Collaborators: name: Amsterdam UMC, location VUmc
name: Erasmus Medical Center
name: Catharina Ziekenhuis Eindhoven
name: Radboud University Medical Center
name: University Medical Center Groningen
name: Jeroen Bosch Ziekenhuis
name: Leiden University Medical Center
name: Maastricht University Medical Center
name: Maasstad Hospital
name: Amphia Hospital
name: Onze Lieve Vrouwe Gasthuis
name: Reinier de Graaf Groep
name: Isala
name: St. Antonius Hospital
First posted: 2020-10-27
Enrollment: 1750
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: All patients registered within the prospective, mandatory Dutch Pancreatic Cancer Audit who underwent resection of histologically proven PDAC.

Brief summary: The aim of this nationwide, observational cohort study is to evaluate current surveillance strategies after primary resection of pancreatic ductal adenocarcinoma (PDAC) in the Netherlands, with regard to the detection, treatment and survival of PDAC recurrence.


Eligibility criteria: Inclusion Criteria:

* Patients undergoing a pancreatic resection (PPPD, Whipple, distal pancreatectomy or total pancreatectomy) for histologically proven PDAC in one of the 16 Dutch centers for pancreatic surgery

Exclusion Criteria:

* Patients with 30-day postoperative mortality

Primary outcomes:
measure: Incidence of PDAC recurrence
timeFrame: Within a follow-up period up to 5 years
measure: Patterns of PDAC recurrence
timeFrame: Within a follow-up period up to 5 years
measure: Treatment of PDAC recurrence
timeFrame: Within a follow-up period up to 5 years
measure: Survival
timeFrame: Within a follow-up period up to 5 years
Secondary outcomes:
measure: Presence of symptoms at time of (suspected) recurrence
timeFrame: Within a follow-up period up to 5 years
measure: Performance score at time of recurrence detection
timeFrame: Within a follow-up period up to 5 years
measure: Use of imaging procedures during follow-up
timeFrame: Within a follow-up period up to 5 years
measure: Number of histologically confirmed recurrences
timeFrame: Within a follow-up period up to 5 years
Other outcomes:
Locations:
city: Utrecht
country: Netherlands
facility: UMC Utrecht
Study officials:
affiliation: UMC Utrecht
name: I. Quintus Molenaar, MD, PhD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT03121937: Feasibility of a Technology-Based Treatment Support System
Official title: Feasibility of a Technology-Based Treatment Support System
Study type: INTERVENTIONAL
Overall status: TERMINATED
Phase: NA
Conditions: Depression
Depressive Disorder, Major
Lead sponsor: Northwestern University
Sponsor class: OTHER
Collaborators: name: National Institute of Mental Health (NIMH)
First posted: 2017-04-20
Enrollment: 11
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: This study aims to evaluate a technology-based treatment support system for patients undergoing the treatment of depression. The investigators will explore the usefulness of the technology-based treatment support system as an adjunct to psychotherapy for depression.

Detailed description: This study aims to evaluate a technology-based treatment support system "mConnect" for patients undergoing the treatment of depression. This system will be evaluated by conducting a randomized controlled trial where patients will either receive the mConnect mobile app or treatment as usual.

Eligibility criteria: Inclusion Criteria:

* 18 years of age or older
* English-speaking
* Currently enrolled in outpatient treatment
* Current diagnosis of major depressive disorder
* Ownership of a smartphone device compatible with the mobile app

Exclusion Criteria

* visual, hearing, voice, or motor impairment that would prevent completion of the study procedures or use of mobile phone
* diagnosis of a psychotic disorder, bipolar disorder, dissociative disorder, substance use disorder, or other diagnosis for which participation in this trial is inappropriate, severe suicidality (has ideation, plan, and intent).
* having completed more than 3 sessions of psychotherapy with current therapist

Primary outcomes:
measure: Retention
timeFrame: 8 weeks
measure: Adherence
timeFrame: 8 weeks
measure: Satisfaction
timeFrame: 8 weeks
Secondary outcomes:
measure: Depression
timeFrame: 8 weeks
Other outcomes:
Locations:
city: Arlington Heights
country: United States
facility: Amita Health
state: Illinois
Study officials:
affiliation: Northwestern University
name: Stephen M Schueller, PhD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT00453037: Effects of a Structured Education Program on Blood Pressure in Essential Hypertensive Patients
Official title: Effects of a Structured Education Program on Blood Pressure in Essential Hypertensive Patients and Effects of a Reminder Program for Physicians to Guide Optimal Therapy
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Hypertension
Keywords: hypertension
self measurement of blood pressure
education program
life style
Lead sponsor: Medical University of Graz
Sponsor class: OTHER
First posted: 2007-03-28
Enrollment: 256
Sex: ALL
Minimum age (years): 18
Maximum age (years): 85
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: PREVENTION

Brief summary: The purpose of this study is to evaluate the effects of a structured educational program for hypertensive patients. The program was developed at the University of Dusseldorf, Germany. The contents of the program are as follows: teaching of the background of hypertension, techniques of self estimation of blood pressure, life style and dietary habits, some information concerning the different pharmacological properties to treat hypertension

Detailed description: see brief description section

Eligibility criteria: Inclusion Criteria:

* Intellectual and physical ability to attend teaching program,
* Capability to do and document blood pressure self-measurement,
* Systolic blood pressure \>160 and/or diastolic blood pressure \>95 mmHg,
* At least 3 months of preexisting medicamentous anti-hypertensive treatment,
* 15% or higher risc in New Zealand Risc Scale

Exclusion Criteria:

* Failing inclusion criteria

Primary outcomes:
measure: Blood pressure at 6 and 12 months of follow up following the educational process
timeFrame: 1 year
Secondary outcomes:
measure: morbidity on different cardiovascular and cerebrovascular diseases
timeFrame: 1 year
Other outcomes:
Locations:
city: Graz
country: Austria
facility: Medical University Graz
state: Styria
Study officials:
affiliation: Medical University Graz Dep of Internal Medicine; Div of Cardiology
name: Robert Zweiker, MD AssocProf
role: PRINCIPAL_INVESTIGATOR
affiliation: Medical University Graz Dept of Internal Medicine Div of Diabetology
name: Thomas R Pieber, MD AssocProf
role: PRINCIPAL_INVESTIGATOR
References:
citation: Perl S, Niederl E, Kos C, Mrak P, Ederer H, Rakovac I, Beck P, Kraler E, Stoff I, Klima G, Pieske BM, Pieber TR, Zweiker R. Randomized Evaluation of the Effectiveness of a Structured Educational Program for Patients With Essential Hypertension. Am J Hypertens. 2016 Jul;29(7):866-72. doi: 10.1093/ajh/hpv186. Epub 2015 Dec 7.
Clinical trial NCT06901037: A Pilot Randomized Controlled Trial of Chatbot Use in Older Adults for Lifestyle Change
Official title: The Acceptability and Preliminary Effectiveness of Using A Smartphone-delivered AI-Based Chatbot in Older Adults for Lifestyle Modification: A Pilot Randomized Controlled Trial
Study type: INTERVENTIONAL
Overall status: NOT_YET_RECRUITING
Phase: NA
Conditions: Healthy Lifestyle
Keywords: Chatbot, older adults
Lead sponsor: The Hong Kong Polytechnic University
Sponsor class: OTHER
First posted: 2025-03-28
Enrollment: 84
Sex: ALL
Minimum age (years): 65
Standard ages: OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: HEALTH_SERVICES_RESEARCH

Brief summary: The purpose of this study is to evaluate the acceptability and preliminary effectiveness of a smartphone-delivered AI-based chatbot in promoting healthy dietary behavior and physical activity participation among older adults.

Detailed description: The purpose of this study is to evaluate the preliminary effectiveness of a smartphone-delivered AI-based chatbot in promoting healthy dietary behavior and physical activity participation among older adults. It is a preliminary study with two arms.

Eligibility criteria: Inclusion Criteria:

* aged 65 or above.
* are community-dwelling.
* are proficient in Mandarin.
* have an Internet connection.
* have at least one instant messaging app on the smartphone or agree to download one.

Exclusion Criteria:

* have any neurocognitive disorders.
* are unable to engage in moderate-intensity level of physical activity due to a preexisting medical condition.
* live with another participant who will participate in this study.

Primary outcomes:
measure: The acceptance of the chatbot among older adults, as measured by a 14-item simplified version of the Senior Technology Acceptance Model questionnaire
timeFrame: End of study (2 months)
measure: The Usability of the chatbot, as measured by the System Usability Scale
timeFrame: End of study (2 months)
measure: The user experience, as measured by 10 open-ended questions
timeFrame: End of study (2 months)
Secondary outcomes:
measure: Change of dietary behavior, as measured by the intake of fruits and vegetables over the last seven days
timeFrame: Baseline, end of study (2 months)
measure: Change of walking, as measured by the Community Health Activities Model Program for Seniors questionnaire
timeFrame: Baseline, end of study (2 months)
measure: Change of total activity and moderate and more vigorous physical activity variables, as measured by the CHAMPS-Q
timeFrame: Baseline, end of study (2 months)
measure: Change of quality of life, as measured by the Hong Kong Quality of Life for Older Persons Scale
timeFrame: Baseline, end of study (2 months)
Other outcomes:
Locations:
city: Hong Kong
country: Hong Kong
facility: The Hong Kong Polytechnic University
Study officials:
affiliation: The Hong Kong Polytechnic University
name: Arkers Wong, PhD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT02694237: The Age of OrthoInfo: A Randomized Controlled Trial Evaluating Patient Comprehension of Informed Consent in a Private Practice
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Knee Osteoarthritis
Lead sponsor: University of Missouri, Kansas City
Sponsor class: OTHER
First posted: 2016-02-29
Enrollment: 66
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The aim of the study is determine which method of informed consent improves comprehension in college educated patients in a private practice setting.


Eligibility criteria: Inclusion Criteria:

* Knee osteoarthritis patients over the age of 18 with a college education deemed appropriate for medical management with a knee injection.

Exclusion Criteria:

* Patients without the capacity to provide consent
* Patients with a visual, auditory, psychological or tactile impairment requiring the assistance of another person.

Primary outcomes:
measure: The Nkem Test
timeFrame: baseline
Secondary outcomes:
Other outcomes:
Locations:
city: Kansas City
country: United States
facility: Truman Medical Center and Dickson-Diveley Orthopaedic Clinic
state: Missouri
Study officials:
affiliation: UMKC Department of Orthopaedic Surgery
name: Nkem Egekeze, MD
role: PRINCIPAL_INVESTIGATOR
affiliation: UMKC Department of Health Insight and Research
name: Karen Williams, PhD
role: STUDY_DIRECTOR
affiliation: UMKC Department of Orthopaedic Surgery
name: Luv Singh, MD
role: STUDY_DIRECTOR
affiliation: Dickson-Diveley Orthopaedic Clinic
name: Dan Gurba, MD
role: STUDY_DIRECTOR
affiliation: UMKC Department of Orthopaedic Surgery
name: Charles Rhoades, MD
role: STUDY_DIRECTOR
affiliation: UMKC Dept of Orthopaedic Surgery
name: Mark Bernhardt, MD
role: STUDY_CHAIR
References:
Clinical trial NCT05221437: Management and Outcome of Fever in Children in Europe
Official title: Personalised Risk Assessment in Febrile Illness to Optimise Real-life Management Across the European Union (PERFORM)
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Antibiotic Prescription
Lead sponsor: Imperial College London
Sponsor class: OTHER
First posted: 2022-02-03
Enrollment: 38480
Sex: ALL
Maximum age (years): 18
Standard ages: CHILD
ADULT
Accepts healthy volunteers: no
Observational model: CASE_ONLY
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Febrile children aged 0- 18 years visiting the emergency care.

Brief summary: This is an observational study assessing the management and outcome of children presenting to Emergency Departments (ED) with fever across Europe.

Detailed description: This is an observational study assessing the management and outcome of children presenting to Emergency Departments (ED) with fever across Europe. This study will use large departmental datasets to collect information on at least 50,000 febrile episodes . This study will use large-scale, pseudo-anonymized departmental data, and will not involve consented patient recruitment; nor will it use patient samples. Data included in MOFICHE will be based on that collected as part of routine clinical care. Antibiotic prescription, hospitalisation and number/type of investigations, re-attendance at ED within 5 days of the first hospital presentation will be recorded.

Eligibility criteria: Inclusion Criteria:

* aged 0- 18 years visiting the emergency care.
* fever measured at ED or history of (measured) fever less than 3 consecutive days prior to presentation at emergency department

Exclusion Criteria:

-

Primary outcomes:
measure: Antibiotic prescription
timeFrame: one year
measure: hospitalization
timeFrame: one year
measure: Number of investigations
timeFrame: one year
measure: Number of children re-attending within 5 days of the first hospital presentation.
timeFrame: one year
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
References:
Clinical trial NCT04697537: Ultrasound-guided Regional Anesthesia vs Local Infiltration Anesthesia With Dexmedetomidine and Ropivacaine
Official title: Dexmedetomidine as Adjunct Medication to Local Infiltration Anesthesia (LIA) vs Ultrasound-Guided Regional Anesthesia (USRA) in Regard to Patients' Need for Opioids, Wellbeing, Satisfaction, and Knee Functionality in Knee-endoprosthetics
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE3
Conditions: Pain, Postoperative
Anesthesia, Local
Gonarthrosis
Lead sponsor: Medical University of Graz
Sponsor class: OTHER
First posted: 2021-01-06
Enrollment: 50
Sex: ALL
Minimum age (years): 18
Maximum age (years): 80
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: Evaluation of the Impact of dexmedetomidine as an adjunct for local infiltrations analgesia and ultrasound-based regional anaesthesia as pain medication in regard to patients' opioid need the first 48 hours after the total knee replacement operation.

Detailed description: Evaluation of the Impact of dexmedetomidine as an adjunct for local infiltrations analgesia and ultrasound-based regional anaesthesia as pain medication in regard to patients' opioid need the first 48 hours after the total knee replacement operation. Secondary objectives are: Pain assesment, Pain medication necessary, functionality of the prothesis, satisfaction, wellbeing, postoperative discomforts, complications (delirium, allergic reactions, cardiopulmonary decompensation), procedure specific time.

Eligibility criteria: Inclusion Criteria:

* Adult
* non pregnant
* patients with gonarthrosis who have given written consent for participation

Exclusion Criteria:

* Age below 18 years
* pregnancy
* breast-feeding patients
* allergies against study medication
* missing or denied written consent

Primary outcomes:
measure: Need of opioid consumption in oral morphine equivalent
timeFrame: 48 hours postoperatively
Secondary outcomes:
measure: Pain assesment
timeFrame: 5 days postoperatively or until discharge
measure: Pain medication necessary
timeFrame: 5 days postoperatively or until discharge
measure: Functionality of the prothesis - OKS (Oxford Knee Score)
timeFrame: 5 days postoperatively or until discharge
measure: Functionality of the prothesis- KOOS (Knee Injury and Osteoarthritis Outcome Score)
timeFrame: 5 days postoperatively or until discharge
measure: Functionality of the prothesis - WOMAC (Western Ontario and McMaster Universities Osteoarthritis Index)
timeFrame: 5 days postoperatively or until discharge
measure: Functionality of the prothesis- G-FJS (German Forgotten Joint Score)
timeFrame: 5 days postoperatively or until discharge
measure: Complications
timeFrame: 5 days postoperatively or until discharge
measure: procedure specific time
timeFrame: during surgery
Other outcomes:
Locations:
city: Graz
country: Austria
facility: Medical University Hospital LKH Graz
Study officials:
affiliation: Med Uni Graz
name: Gregor A Schittek, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT00940537: Magnetic Resonance Spectroscopy (MRS) Validation Study in Individuals With Nonalcoholic Fatty Liver Disease (NAFLD)
Official title: MRS Validation Study of Hepatic Triglyceride Content in Non-alcoholic Fatty Liver Disease (NAFLD)Subjects Pre- and Post-Prandial
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Liver Diseases
Keywords: Obese
MRS
hepatic triglyceride content
MR spectroscopy
Lead sponsor: Washington University School of Medicine
Sponsor class: OTHER
First posted: 2009-07-16
Enrollment: 14
Sex: ALL
Minimum age (years): 18
Maximum age (years): 65
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: COHORT
Time perspective: CROSS_SECTIONAL
Sampling method: NON_PROBABILITY_SAMPLE
Study population: St. Louis community

Brief summary: The purpose of this study is to see how effective the investigators' optimized magnetic resonance spectroscopy (MRS) sequence in quantifying hepatic triglyceride content (HTGC) to enhance MRS as a diagnostic tool in non-alcohol fatty liver disease (NAFLD).

Detailed description: One way to gauge MRS as an effective diagnostic tool is by looking at the reproducibility of the liver fat measurements on subjects by calculating the coefficient of variation (CV). This study assesses the modified MRS sequence, using both breath holds and free breathing. The HTGC levels are measured twice in the same individuals on two independent events separated by 10 minutes. Subjects are then given a high fat, high carbohydrate meal of Pizza Hut pizza, Pepsi, and Oreo cookies. Two hours after eating the meal, the subjects return to the scanner and repeat all MRS scans.

Eligibility criteria: Inclusion Criteria:

* Obese

Exclusion Criteria:

* Diabetes
* Pregnant

Primary outcomes:
measure: The Reproducibility of the Hepatic Triglyceride Content Measurement by MRS.
timeFrame: 6 months
Secondary outcomes:
measure: The Hepatic Triglyceride Content Pre- and Post-prandial.
timeFrame: after a 12 hour fast and 2 hours post-prandial
measure: T2 (Spin-spin Relaxation Time) Ratios of Triglyceride/Water
timeFrame: baseline cross-sectional measurements
Other outcomes:
Locations:
city: Saint Louis
country: United States
facility: Barnes Jewish Hospital
state: Missouri
Study officials:
affiliation: Washinton University in St. Louis
name: Samuel Klein, M.D.
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT05164237: Multimodal Approach of Electrotherapy Versus Nerve Flossing Technique in Patient With Carpal Tunnel Syndrome
Official title: Multimodal Approach of Electrotherapy Versus Nerve Flossing Technique in Patient With Carpal Tunnel Syndrome
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Carpal Tunnel Syndrome
Keywords: Carpal Tunnel Syndrome
Lead sponsor: October 6 University
Sponsor class: OTHER
First posted: 2021-12-20
Enrollment: 76
Sex: ALL
Minimum age (years): 30
Maximum age (years): 45
Standard ages: ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: OTHER

Brief summary: Carpal tunnel syndrome (CTS) is the most common and median nerve neuropathy at the wrist, caused by compression of the median nerve at the level of the carpal tunnel (CT) delimitated by the carpal bones and the transverse carpal ligament(TCL) which is the intermediate part of the flexor retinaculum (FR).

The CTS remains a challenge for health care providers due to its high prevalence and economic consequences, it is projected that in every 5 patients, 1 complains of symptoms of pain, numbness and a tingling sensation in the hands, CTS is estimated to occur in 3.8% of the general population with an incidence rate of 276:100000 per year and happens more frequently in women than in men so a prevalence rate of 9.2% in women and 6% in men

Detailed description: The CTS is a common clinical problem caused by the entrapment of the median nerve at the wrist, It is an important mononeuropathy that causes of hand pain, neurologic symptoms, and functional limitation of the hand, It is the most common nerve compression disorder of the upper extremity ,it accounting for 90% of all neuropathies, It is estimated that CTS affects approximately is between 3.7% and 5.8% of the general population with a prevalence rate up to 9.2% in women and 6% in men , CTS is 10 times more frequent in women than men , the peak age range of CTS is between 40 to 60 years ,it is mostly seen in women ages between 30 to 50 years due to the housework they do, however, it occurs in all age groups

Eligibility criteria: Inclusion Criteria:

Fifty one female patients have unilateral with mild to moderate CTS in dominant hand diagnosed and reffered by physician.

Age will be ranged from 30-45years (Atya et al.,2020) Patients with mild to moderate CTS will particiepate into the current study according to the classification of AAEM

Exclusion Criteria:

Patients with diabetes mellities ( type I or type II), Patients with Hypertension Patients with hypothyroidism Patients with rheumatological disease Patients with renal disease

Primary outcomes:
measure: Weight and height scale
timeFrame: 8 weeks
measure: Visual analogue scale
timeFrame: 8 weeks
Secondary outcomes:
Other outcomes:
Locations:
city: Cairo
country: Egypt
facility: Heba
Study officials:
References: