Clinical trial NCT04532606: Impact of Remimazolam on Prognosis After Bladder Cancer Surgery
Official title: Impact of Remimazolam Tosilate for General Anesthesia on Prognosis After Bladder Cancer Surgery: a Randomized Controlled Trial
Study type: INTERVENTIONAL
Overall status: RECRUITING
Phase: PHASE4
Conditions: Benzodiazepines
Bladder Cancer
Delirium
Surgery
Cancer Recurrence
Keywords: Remimazolam
Bladder Cancer
Surgery
Emergence Delirium
Recurrence-free Survival
Lead sponsor: Peking University First Hospital
Sponsor class: OTHER
Collaborators: name: Beijing Tsinghua Chang Gung Hospital
name: Navy General Hospital, Beijing
name: Guizhou Provincial People's Hospital
name: Jiangsu Provincial People's Hospital
name: Shanghai 10th People's Hospital
First posted: 2020-08-31
Enrollment: 1128
Sex: ALL
Minimum age (years): 50
Maximum age (years): 90
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: PREVENTION

Brief summary: Bladder cancer is one of the most common genitourinary cancers. Transurethral resection of bladder tumor (TURBT) is the standard therapy for nonmuscle invasive bladder cancer. However, patients after TURBT are at risk for recurrence and progression. Benzodiazepines are proved to inhibit proliferation of multiple types of cancer cells in vitro. Delirium is an acute onset and transient cerebral dysfunction and is associated with worse outcomes. Previous studies indicated that benzodiazepines increase incidence of postoperative delirium. Remimazolam is a new benzodiazepine with rapid onset and ultra-short activity. The aims of this study are to explore the impact of remimazolam for general anesthesia on emergency delirium and recurrence-free survival in patients undergoing bladder cancer surgery.

Detailed description: Bladder cancer is one of the most common genitourinary cancers. Approximately 70-80% of bladder cancers are nonmuscle invasive, including those of Ta-T1 stage and carcinoma in situ. Transurethral resection of bladder tumor (TURBT) is the standard therapy for nonmuscle invasive bladder cancer. However, patients after TURBT are at a high risk of recurrence and progression.

Recently, impacts of anesthetic agents on tumor cells have attracted more attention. Benzodiazepines are found to inhibit proliferation of lymphoma, neural tumor, lung cancer, rectal cancer and breast cancer cells in vitro. Midazolam may have anti-tumor effects through induction of apoptosis and inhibition of inflammatory reaction. However, clinical evidence regarding effects of benzodiazepines on outcomes after cancer surgery remains lacking.

Remimazolam is a new benzodiazepine with rapid onset and ultra-short activity. It is rapidly metabolized by tissue esterases to inactive metabolite and can be reversed by flumazenil. Therefore, patients wake up rapidly even after prolonged infusions. It is also found to produce less respiratory and circulatory depression when compared with propofol.

Delirium is an acute onset and transient cerebral dysfunction, and is associated with worse outcomes including prolonged hospitalization, worse functional recovery, cognitive decline, and increased mortality rate. Previous studies indicated that benzodiazepines increase incidence of postoperative delirium, possibly due to prolonged action. With the property of ultra-short activity, remimazolam may not increase the incidence of delirium. But evidence is lacking in this aspect.

The aims of this study are to explore the impact of remimazolam on emergency delirium and recurrence-free survival in patients undergoing bladder cancer surgery.

Eligibility criteria: Inclusion Criteria:

1. Age ≥50 years and \<90 years;
2. Preoperative diagnosis is non-muscle-invasive bladder cancer(Ta-T1);
3. Scheduled to undergo transurethral resection of bladder tumor;
4. Agree to participate, and provide written informed consent.

Exclusion Criteria:

1. Refuse to participate;
2. Emergent surgery;
3. Combined with other malignant tumors;
4. Use of benzodiazepines for 1 week within the last month before surgery;
5. Preoperative history of schizophrenia, epilepsy, parkinsonism or myasthenia gravis;
6. Inability to communicate in the preoperative period due to coma, profound dementia, language barrier, or end-stage disease;
7. Critical illness (preoperative American Society of Anesthesiologists physical status classification ≥IV), severe hepatic dysfunction (Child-Pugh class C), or severe renal dysfunction (undergoing dialysis before surgery);
8. The purpose of surgery is to make a diagnosis or preoperative judgement is that tumor cannot be completely removed.

Primary outcomes:
measure: Incidence of emergence delirium (early).
timeFrame: Up to 2 hours during the stay in post-anesthesia care unit after surgery.
measure: Recurrence-free survival (long-term).
timeFrame: Up to 3 years after surgery.
Secondary outcomes:
measure: Incidence of postoperative delirium (early).
timeFrame: During the first 3 days after surgery.
measure: Incidence of postoperative nausea and vomiting (early).
timeFrame: Up to 24 hours after surgery.
measure: Incidence of intraoperative awareness (early).
timeFrame: Up to 1 day after surgery.
measure: Length of stay in hospital after surgery (early).
timeFrame: Up to 30 days after surgery.
measure: Incidence of non-delirium complications (early).
timeFrame: Up to 30 days after surgery.
measure: All-cause 30-day mortality (early).
timeFrame: Up to 30 days after surgery.
measure: Overall survival (long-term).
timeFrame: Up to 3 years after surgery.
measure: Event-free survival (long-term).
timeFrame: Up to 3 years after surgery.
measure: Health related quality of life of 1-year survivors (long-term).
timeFrame: At the end of the 1st year after surgery.
Other outcomes:
measure: Intensity of pain (early).
timeFrame: During the first 3 days after surgery.
measure: Subjective sleep quality (early).
timeFrame: During the first 3 days after surgery
Locations:
city: Beijing
country: China
facility: Beijing Tsinghua Chang Gung Hospital
state: Beijing
city: Beijing
country: China
facility: The Sixth Medical Center of PLA General Hospital
state: Beijing
city: Beijin
country: China
facility: Peking University First Hospital
state: Bejing
city: Guiyang
country: China
facility: Guizhou Provincial People's Hospital
state: Guizhou
city: Nanjing
country: China
facility: Jiangsu Provincial People's Hospital
state: Jiangsu
city: Shanghai
country: China
facility: Shanghai 10th People's Hospital
state: Shanghai
Study officials:
affiliation: Peking University First Hospital
name: Wang Dong-Xin, MD, PhD
role: PRINCIPAL_INVESTIGATOR
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