Clinical trial NCT03922113: Muscle Function After Intensive Care
Official title: Muscle Strength and Function After Intensive Care, Compared to Surgical and Healthy Subjects
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Critically Ill
Colorectal Surgery
Healthy
Muscle Strength
Lead sponsor: University of Liege
Sponsor class: OTHER
First posted: 2019-04-19
Enrollment: 104
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: * Collaborative ICU patients with length of stay \> 48h
* Surgical patients scheduled for colorectal surgery
* Healthy subjects

Brief summary: Final objective of critical care is no longer only survival. The role of medical and paramedical teams should also be to restore functional capacities, autonomy and quality of life. What has been call "intensive care unit - acquired weakness" (ICU-AW) is associated to acute and long term increased mortality, prolonged ICU and hospital stay, prolonged duration of mechanical ventilation, altered quality of life in survivors and increased health-related costs. In order to target efficient secondary prevention and early rehabilitation, prompt identification of muscle weakness is crucial. Several methods, aiming to assess muscle mass, muscle strength or physical function, are described. Manual muscle testing using the Medical Research Council (MRC) scale is still the most commonly utilized tool to diagnose ICU-AW (MRC \<48/60). Dynamometry is an objective alternative and one of the most accurate clinimetric tool to assess muscle strength. Literature is overflowing with insufficiently standardized dynamometry data. Using the investigator's published standardized protocol of quadriceps strength (QS) assessment, this observational study aim to describe physical performances of CC patients and thus to define the weakest ones, by comparing them to surgical and healthy subjects.


Eligibility criteria: Inclusion Criteria:

* Collaborative ICU patients with length of stay \> 48h
* Surgical patients scheduled for colorectal surgery
* Healthy subjects

Exclusion Criteria:

* a score \> 1 or \< -1 on the Richmond Agitation and Sedation Scale (RASS)
* coma
* total hip or knee arthroplasty in the dominant limb
* unauthorized support on the dominant leg
* open wound located at the ankle's anterior face of the dominant leg
* pre-existing myopathy or polyneuropathy
* para- or tetraparesis, para- or tetraplegia
* refusal.

Primary outcomes:
measure: Change in Quadriceps strength
timeFrame: For critically ill patients: T0 (as soon as they were collaborative in ICU) and M1 (at one month following discharge), for surgical patients at T0 (day before surgery) and at M1 (one month following discharge), for healthy subjects: T0
Secondary outcomes:
measure: Change in Medical Research Council test (MRC)
timeFrame: For critically ill patients: T0 (as soon as they were collaborative in ICU) and M1 (at one month following discharge), for surgical patients at T0 (day before surgery) and at M1 (one month following discharge), for healthy subjects: T0
measure: Change in 4-items Physical Function Intensive care Test (PFIT-s)
timeFrame: For critically ill patients: T0 (as soon as they were collaborative in ICU) and M1 (at one month following discharge), for surgical patients at T0 (day before surgery) and at M1 (one month following discharge), for healthy subjects: T0
measure: Change in Barthel index for activities of daily living
timeFrame: For critically ill patients: T0 (as soon as they were collaborative in ICU) and M1 (at one month following discharge), for surgical patients at T0 (day before surgery) and at M1 (one month following discharge), for healthy subjects: T0
Other outcomes:
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