louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT03618147: Primary Immunodeficiency in Kuwait
Official title: Kuwait National Primary Immunodeficiency Registry (KNPIDR)
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Primary Immune Deficiency Disorder
Lead sponsor: Kuwait Society for Allergy and Clinical Immunology
Sponsor class: OTHER
First posted: 2018-08-07
Enrollment: 314
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: OTHER
Sampling method: NON_PROBABILITY_SAMPLE
Study population: PIDD patients in Kuwait

Brief summary: * Background/Rationale: Epidemiological data about Primary Immunodeficiency Disorders (PIDD) in Kuwait is needed to better understand peculiarities and to compare them with other regions and ethnicity.
* Study hypothesis: PIDD is relatively common in Kuwait compared to populations from different geographic areas. The distribution of PIDD in Kuwait is different from other geographic areas with more severe forms being more frequent.
* Brief inclusion and exclusion criteria of study participants: PIDD patients presented at different clinics/hospital in Kuwait. Patients with secondary immunodeficiencies (drug induced, virus induced, and immunodeficiency associated with metabolic disorders... ect), will be excluded
* Estimated sample size of the study: All patients who were registered in KNPIDR since 2004 will be included in the study along with the new patients who will be recruited during the study period.
* Primary objectives:

  * Determine the prevalence and frequency of different PIDD in Kuwait
  * Identify clinical presentation patterns for PIDD in Kuwait
  * Identify natural history of PIDD in Kuwait
  * Help to asses epidemiology of PIDD in Kuwait
  * Determine particularities about PIDD affecting the population in Kuwait
  * Determine the health impact of PIDD in Kuwait
  * Development of strategies to improve the care and the quality of life of patients with PIDD


Eligibility criteria: Inclusion Criteria:

* PIDD patients presented at different clinics/hospital in Kuwait
* Exclusion Criteria: Patients with secondary immunodeficiencies (drug induced, virus induced, and immunodeficiency associated with metabolic disorders... ect)

Primary outcomes:
measure: Number of Participants With Different Epidemiological Features
timeFrame: 15 years
measure: Number of Overall and New Cases of PID Per 100,000 Kuwaitis
timeFrame: 15 years
Secondary outcomes:
Other outcomes:
Locations:
city: Kuwait
country: Kuwait
facility: Pediatric Deprtmemt, Alsabah hospital
Study officials:
References:
Clinical trial NCT03109977: Imaging With a New Agent That Finds a Cancer Protein Called HER2
Official title: First-in-human Imaging With 89Zr-DFO-pertuzumab in Patients With HER2 Positive Malignancies
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE1
Conditions: HER2-positive Carcinoma
HER2-positive Primary Malignancy
Keywords: 17-059
Zr-DFO-pertuzumab
Lead sponsor: Memorial Sloan Kettering Cancer Center
Sponsor class: OTHER
First posted: 2017-04-12
Enrollment: 6
Sex: ALL
Minimum age (years): 21
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: DIAGNOSTIC

Brief summary: The purpose of this study is to test if an imaging agent called Zr-DFO-pertuzumab that finds HER2 proteins can be used to take pictures of HER2-positive cancer.


Eligibility criteria: Inclusion Criteria:

* Age 21 years or greater
* Any biopsy proven HER2-positive malignancy. ASCO guidelines will be used to define HER2-positivity for breast cancer. Similar guidelines will be used for other cancer types as appropriate.
* At least one malignant lesion on CT, MR, or FDG PET/CT within 60 days of protocol enrollment
* ECOG performance of 0-2

Exclusion Criteria:

* Life expectancy \< 3 months
* Pregnancy or lactation
* Patients who cannot undergo PET/CT scanning because of weight limits. PET/CT scanners may not be able to function with patients over 450 pounds.

Primary outcomes:
measure: Number of Participants With Treatment-Related Adverse Events, including vital signs as Assessed by CTCAE v4.0
timeFrame: 1 year
Secondary outcomes:
Other outcomes:
Locations:
city: New York
country: United States
facility: Memorial Slaon-Kettering Cancer Center
state: New York
Study officials:
affiliation: Memorial Sloan Kettering Cancer Center
name: Gary Ulaner, MD, PhD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT01481077: A Dose Evaluation Study of the Effect of Plug Placement on the Efficacy and Safety of the Latanoprost Punctal Plug Delivery System (L-PPDS) in Subjects With Ocular Hypertension or Open-Angle Glaucoma
Official title: PPL GLAU 13: A Randomized Phase 2 Study of the Effect of Plug Placement on Efficacy and Safety of the Latanoprost Punctal Plug Delivery System (L-PPDS) in Subjects With Ocular Hypertension (OH) or Open-Angle Glaucoma (OAG)
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE2
Conditions: Glaucoma
Ocular Hypertension (OH)
Lead sponsor: Mati Therapeutics Inc.
Sponsor class: INDUSTRY
First posted: 2011-11-29
Enrollment: 77
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The purpose of this study is to determine the effect of plug placement on the efficacy, safety and duration of effect of the L-PPDS (latanoprost punctal plug delivery system).


Eligibility criteria: Inclusion Criteria:

* Male or female at least 18 years old
* Diagnosis of bilateral open angle glaucoma or ocular hypertension
* Unmedicated IOP must be ≥22mm Hg

Exclusion Criteria:

* Any significant vision loss in the last year
* No contact lens use for the length of the study
* Abnormal eye lids, eye infection or diseases to the eye
* Recent eye surgery
* Uncontrolled medical conditions

Primary outcomes:
measure: IOP change from baseline
timeFrame: 12 weeks to baseline
Secondary outcomes:
Other outcomes:
Locations:
city: Springdale
country: United States
facility: Vold Vision
state: Arkansas
city: Denver
country: United States
facility: Glaucoma Consultants of Colorado, PC
state: Colorado
city: Danbury
country: United States
facility: Danbury Eye Physicians & Surgeons
state: Connecticut
city: Des Peres
country: United States
facility: Ophthalmology Consultants Inc.
state: Missouri
city: St. Louis
country: United States
facility: Ophthalmology Associates
state: Missouri
city: Washington
country: United States
facility: Comprehensive Eye Care, Ltd
state: Missouri
city: Henderson
country: United States
facility: Las Vegas Physicians Research Group
state: Nevada
city: Las Vegas
country: United States
facility: Abrams Eye Institute
state: Nevada
city: Philadelphia
country: United States
facility: Philadelphia Eye Associates
state: Pennsylvania
city: Maryville
country: United States
facility: University Eye Surgeons
state: Tennessee
city: Memphis
country: United States
facility: Total Eye Care, P.A.
state: Tennessee
Study officials:
affiliation: QLT Inc.
name: Suzanne Cadden
role: STUDY_DIRECTOR
References:
Clinical trial NCT03850977: Is There an Association Between Chronic Pancreatitis and Pulmonary Function
Official title: Association Between Chronic Pancreatitis and Respiratory Dysfunction: A Prospective Cohort Study?
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Chronic Pancreatitis
Respiratory Insufficiency
Cirrhosis, Liver
Lung Function Decreased
Healthy
Lead sponsor: Copenhagen University Hospital, Hvidovre
Sponsor class: OTHER
First posted: 2019-02-22
Enrollment: 100
Sex: ALL
Minimum age (years): 18
Maximum age (years): 90
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: We plan to include patients with chronic pancreatitis, cirrhosis and healthy controls

Brief summary: To evaluate pulmonary function in chronic pancreatitis compared with healthy volunteers and patients with cirrhosis.


Eligibility criteria: Inclusion Criteria:

* Patients with chronic pancreatitis or cirrhosis
* Healthy controls

Exclusion Criteria:

* Lack of informed consent
* Known chronic lung disease

Primary outcomes:
measure: Diffusion capacity of the lung for carbon monoxide
timeFrame: Three years
measure: Alveolar volume
timeFrame: Three years
Secondary outcomes:
Other outcomes:
Locations:
city: Hvidovre
country: Denmark
facility: Gastrounit, Copenhagen University Hospital Hvidovre
state: Capital Region Denmark
Study officials:
References:
Clinical trial NCT06948877: "Up-Armoring" At-Risk Military Couples: A Stepped Approach to Early Intervention and Strengthening of Military Families
Official title: "Up-Armoring" At-Risk Military Couples: A Stepped Approach to Early Intervention and Strengthening of Military Families
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Couples Therapy
Military Family
Lead sponsor: Wright State University
Sponsor class: OTHER
Collaborators: name: Family Translational Research Group
name: Texas A&M University
name: Binghamton University
First posted: 2025-04-29
Enrollment: 581
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Intervention model description: Participants were randomly assigned by in-processing week to the intervention or the control condition.
Primary purpose: PREVENTION

Brief summary: The study tested whether giving young, partnered military service members access to an online relationship help website would help prevent future relationship problems compared to partnered service member who did not have access to the website

Detailed description: This study tested whether access to a self-directed, online couple intervention offered preventively lessened the occurrence of future negative relationship outcomes (i.e., relationship dysfunction, infidelity, intimate partner violence (IPV) for partnered service members in comparison to the usual resources for relationship assistance in the military. Participants were active-duty military in a committed romantic relationship of at least 6-months duration (N = 581; 37.2% married) who had recently completed basic military training and were transitioning into technical training to learn a specific job skill set. Participants were randomly assigned by in-processing week to the intervention or the control condition. The intervention effect was modeled using both Intent to Treat (ITT) and Complier Average Causal Effect (CACE) approaches.

Eligibility criteria: Inclusion Criteria:

* To be included in the study, participants had to be: (a) in a committed romantic relationship for at least six months and (b) on active duty (not Guard or Reserve).

Exclusion Criteria:

* Participants with prior military service (i.e., not new to the military who were retraining into a different career field) were excluded.

Primary outcomes:
measure: Marital Satisfaction Inventory-Brief (MSI-B; Whisman et al., 2009)
timeFrame: six months
measure: Family Maltreatment measure (Heyman et al., 2021)
timeFrame: six months
measure: Infidelity
timeFrame: six months
Secondary outcomes:
Other outcomes:
Locations:
city: Biloxi
country: United States
facility: Keesler Air Force Base
state: Mississippi
Study officials:
References:
Clinical trial NCT05444777: The Effect of Low Dose Ketamine on Narcotic Consumption in Patients Undergoing Laparoscopic Cholecystectomy
Official title: The Effect of Low Dose Ketamine on Narcotic Consumption in Patients Undergoing Laparoscopic Cholecystectomy
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Cholelithiasis
Lead sponsor: Aga Khan University
Sponsor class: OTHER
First posted: 2022-07-06
Enrollment: 86
Sex: ALL
Minimum age (years): 18
Maximum age (years): 65
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Intervention model description: Randomized control trial
Primary purpose: PREVENTION

Brief summary: This double-blinded randomized control trial aims to analyze the effect of low dose Ketamine on narcotic consumption, in patients undergoing Laparoscopic cholecystectomy.


Eligibility criteria: Inclusion Criteria:

* all ASA 1 and 2 patients undergoing Laparoscopic Cholecystectomy electively.

Exclusion Criteria:

* Hepatic and renal disease and ASA 3 and 4 patients.

Primary outcomes:
measure: pain score using Visual Analogue scale, ranging from 0 (minimum) and 10 (maximum), 3 and below showing no pain and scores above 3 showing moderate to severe pain.
timeFrame: Baseline on arrival in the post anaesthesia care unit and then every fifteen minutes unto one hour
Secondary outcomes:
measure: narcotic consumption in the post operative anaesthesia care unit
timeFrame: postoperatively, after arrival in the post anaesthesia care unit at every fifteen minutes unto one hour
Other outcomes:
Locations:
Study officials:
References:
Clinical trial NCT03780777: Removing Home Hazards for Older Adults in Affordable Housing
Official title: Removing Home Hazards for Older Adults in Affordable Housing
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Accidental Fall
Keywords: older adult falls
home hazards
home barriers
Lead sponsor: Washington University School of Medicine
Sponsor class: OTHER
Collaborators: name: US Department of Housing and Urban Development
First posted: 2018-12-19
Enrollment: 524
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: HEALTH_SERVICES_RESEARCH

Brief summary: The investigators will conduct a hybrid effectiveness/implementation trial to simultaneously establish the effectiveness of home hazard removal in affordable housing in order to reduce falls, and conduct a process evaluation of how the intervention works in the context of low-income senior apartments.

Detailed description: The investigators, in collaboration with the community partner, will offer the program to all building residents in select low-income senior apartments. The eligibility criteria include a self-report of one or more falls in the preceding 12 months, a fear of falling, or unsteadiness while standing or walking. The investigators will screen residents and determine their risk for falling. Residents who are high risk will be referred to licensed occupational therapy practitioners for baseline assessments and home hazard removal. Residents will be re-assessed at 3 months. All assessments will be conducted in the residents' apartment buildings. Outcomes (falls, program evaluation) will be collected by our community partner.

Eligibility criteria: Inclusion Criteria:

* Residents who live in any of the eligible section 202 low-income senior apartment units managed by our community partner

Exclusion Criteria:

* Individuals who do not reside in any of the eligible units

Primary outcomes:
measure: Resident enrollment in home hazard removal intervention
timeFrame: 609 days
measure: Program fidelity
timeFrame: 609 days
Secondary outcomes:
measure: Number of falls
timeFrame: 609 days
measure: Cost per fall prevented
timeFrame: 609 days
measure: Adherence to home hazard removal intervention recommendations
timeFrame: 609 days
Other outcomes:
Locations:
city: Saint Louis
country: United States
facility: Washington University School of Medicine
state: Missouri
Study officials:
affiliation: Washington University School of Medicine
name: Susan Stark, PhD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT00567177: Objective Measurements of Prolonged Effects of Restasis on Dry Eye Disease
Official title: Objective Measurements of Prolonged Effects of Restasis on Dry Eye Disease
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE4
Conditions: Treatment of Dry Eye Disease
Lead sponsor: Innovative Medical
Sponsor class: INDUSTRY
First posted: 2007-12-04
Enrollment: 40
Sex: ALL
Minimum age (years): 13
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: We propose to investigate the response to Restasis, over a prolonged period of time in heavy computer users with dry eye disease.


Eligibility criteria: Inclusion Criteria:

* Using computers more than three hours per day
* Having dry eye symptoms based on results on the OSDI Scores of 15 or greater on the OSDI will be considered to have the disorder
* An abnormal confocal image of 5 or greater.

Exclusion Criteria:

* All corneal disorders except for tear disorders.

Primary outcomes:
measure: Dry Eye disease
timeFrame: 6 months
Secondary outcomes:
measure: efficacy
timeFrame: 6 months
Other outcomes:
Locations:
city: 6400 Fannin Ste 1800
country: United States
facility: Hermann Eye Center
state: Texas
Study officials:
affiliation: Hermann Eye Center
name: Richard Yee, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT04450277: Delivery of Protocolised Emergency Surgical Care During COVID-19 Pandemic
Official title: Delivery of Protocolised Emergency Surgical Care During COVID-19 Pandemic Based on Case Series
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: COVID-19
Emergency Surgery
Lead sponsor: Khoo Teck Puat Hospital
Sponsor class: OTHER
First posted: 2020-06-29
Enrollment: 15
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: A propsective review was performed of all patients with laboratory-confirmed COVID-19 infection who presented with acute general surgical conditions to Khoo Teck Puat Hospital (KTPH), in the period of 1st April 2020 to 31st May 2020. KTPH is a 795-bed regional general hospital in Singapore that serves approximately half a million people in the northern part of the city state. A confirmed case of COVID-19 was defined by a positive result on a reverse-transcriptase-polymerase-chain-reaction (RT-PCR) assay of a specimen collected on a nasopharyngeal swab. Patients underwent testing on admission if identified as high risk as per national guidelines, or upon developing respiratory symptoms during inpatient stay.

Brief summary: Emergency general surgical care during the COVID-19 pandemic presents a unique set of considerations and challenges. Patients presenting with acute surgical conditions and concomitant COVID-19 infection have higher risk of mortality and morbidity. The investigators present their experience with COVID-19 positive patients presenting with acute surgical conditions and reviewed the implementation of a protocolized pathway to mitigate the impact of COVID-19 infection.

Detailed description: All COVID-19 positive patients who presented to the acute general surgical service over a 2-month period were identified. Patient data including demographics, surgical diagnosis, mortality, morbidity and hospital length of stay was collected. Based on the investigators' early experience from the first patient, the investigators designed a protocolized institutional pathway which incorporated the risk of COVID-19 infection and urgency of operation.

Eligibility criteria: Inclusion Criteria:

* All patients with emergency surgical conditions and tested positive for COVID-19 infection

Exclusion Criteria:

* Nil

Primary outcomes:
measure: Surgical morbidity in patients with COVID-19 infection and general surgical conditions
timeFrame: Follow up 1 month
Secondary outcomes:
Other outcomes:
Locations:
city: Singapore
country: Singapore
facility: Khoo Teck Puat Hospital
Study officials:
References:
Clinical trial NCT06720077: Effect of Acupressure in The Management of Postmenopausal Constipation
Official title: Effect of Acupressure in The Management of Postmenopausal Constipation
Study type: INTERVENTIONAL
Overall status: NOT_YET_RECRUITING
Phase: NA
Conditions: Constipation
Lead sponsor: Cairo University
Sponsor class: OTHER
First posted: 2024-12-06
Enrollment: 60
Sex: FEMALE
Minimum age (years): 50
Maximum age (years): 60
Standard ages: ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: This study was conducted to investigate the effect of acupressure in the management of constipation in postmenopausal women.

Detailed description: Constipation is prevalent in menopause, affecting 4-29% of women globally, and can lead to serious complications like hemorrhoids, anal fissures, and colorectal cancer. While laxatives can help, long-term use may cause dependency and side effects. Alternative therapies are needed.

Deep breathing, particularly diaphragmatic breathing, may improve constipation by activating the parasympathetic system and promoting relaxation. Acupressure has also shown potential in managing constipation by stimulating intestinal activity, improving blood circulation, and regulating Qi flow.

Despite existing studies on acupressure and constipation, no research has specifically examined its effect on postmenopausal women. This study aims to investigate acupressure's impact on functional constipation in this population, offering potential insights for non-pharmacological management.

Eligibility criteria: Inclusion Criteria:

1. Sixty postmenopausal women who were clinically diagnosed as having functional constipation after menopause (at least one year after the stoppage of the last menstrual cycle)
2. Their ages ranged from 50 to 60 years old.
3. Their body mass index didn't exceed 30 kg/m2.
4. All of them should have at least two criteria of Rome III diagnostic criteria of constipation.
5. They should stop laxatives intake during the treatment program.

Exclusion Criteria:

1. Irritable bowel syndrome or anal fissures.
2. Genital organ prolapse as rectocele.
3. Any neurological diseases, spinal diseases or spinal deformities.
4. History of bowel surgery.
5. Congenital anorectal malformation, stoma in situ.
6. Diabetes mellitus and sever distal venous insufficiency.
7. Skin eruption at the site of stimulation.
8. Implanted pacemaker or defibrillator.
9. Metalic implant in lower limb.
10. Recent surgery at the lower limb.
11. Peripheral neuropathy and neurological disorders.
12. Psychological distress.

Primary outcomes:
measure: Patient Assessment of Constipation Symptom (PAC - SYM)
timeFrame: 6 weeks
measure: Patient Assessment of Constipation quality of life (PAC - QOL)
timeFrame: 6 weeks
Secondary outcomes:
Other outcomes:
Locations:
city: Giza
country: Egypt
facility: Faculty of physical therapy, Cairo University
Study officials:
affiliation: Professor, Cairo university
name: Azza Barmoud Nashed Kassab, PhD
role: STUDY_CHAIR
References: