Clinical trial NCT05671341: Comparison of Balance, Activity-specific Balance Confidence and Quality of Life in Parkinson's Patients
Official title: Comparison of Balance, Activity-specific Balance Confidence and Quality of Life in Parkinson's Patients with Freezing and Relationship Between Neutrophil/lymphocyte Ratio
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Idiopathic Parkinson's Disease
Keywords: Parkinson's disease
Balance
Balance confidence
Quality of life
Freezing
Neutrophil/Lymphocyte ratio
Lead sponsor: Nigde Omer Halisdemir University
Sponsor class: OTHER
First posted: 2023-01-04
Enrollment: 61
Sex: ALL
Minimum age (years): 50
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: CASE_CONTROL
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Parkinson's patients who applied to Nigde Omer Halisdemir University Training and Research Hospital Neurology Clinic will be included in this study.

Brief summary: Parkinson's disease is characterized by cardinal motor signs and motor freezing, gait, posture and balance disorder. About 80% of the causes of falls in Parkinson's patients are due to postural instability and motor freezing, and patients' quality of life is significantly affected. Loss of balance and falls, which are frequently experienced in Parkinson's patients, cause individuals to feel insecure during activities. It is thought that the quality of life of PD patients whose movements are restricted due to the fear of falling may also be negatively affected. The neutrophil/lymphocyte ratio is a marker of peripheral inflammation. The relationship of peripheral inflammation to balance, activity-specific balance confidence, and quality of life in individuals is unclear. The aim of this study was to compare balance, activity-specific balance confidence, quality of life, and the relationship between neutrophil/lymphocyte ratio in Parkinson's patients with and without freezing.

Detailed description: Parkinson's disease is characterized by cardinal motor signs and motor freezing, gait, posture and balance disorder. About 80% of the causes of falls in Parkinson's patients are due to postural instability and motor freezing, and patients' quality of life is significantly affected. Loss of balance and falls, which are frequently experienced in Parkinson's patients, cause individuals to feel insecure during activities. It is thought that the quality of life of PD patients whose movements are restricted due to the fear of falling may also be negatively affected. The neutrophil/lymphocyte ratio is a marker of peripheral inflammation. The relationship of peripheral inflammation to balance, activity-specific balance confidence, and quality of life in individuals is unclear.

The aim of this study was to compare balance, activity-specific balance confidence, quality of life, and the relationship between neutrophil/lymphocyte ratio in Parkinson's patients with and without freezing.

A total of 20 Parkinson's Disease age of older the 50 participate in the research. Participants were divide into two groups with and without freezing.

Eligibility criteria: Inclusion Criteria:

* Being diagnosed with idiopathic Parkinson's disease
* Healthy individuals who do not have musculoskeletal disease or any neurological disease that may affect assessments
* Older than 50 years old
* Volunteer to participate in the study
* Grade 1-3 on the Modified Hoehn-Yahr Scale
* To have a score above 24 in the Standardized Mini Mental Test
* To have a hemogram follow-up in the last 1 month before the date of participation in the study.
* Being able to walk independently on flat ground

Exclusion Criteria:

* Having an additional or psychiatric disease other than Parkinson's disease
* Lack of cooperation
* Presence of orthopedic problems (such as fractures, osteoporosis, osteomyelitis)

Primary outcomes:
measure: Freezing of Gait Questionnaire
timeFrame: Baseline
measure: The Tinetti Balance and Gait Test
timeFrame: Baseline
measure: Activity-Specific Balance Confidence
timeFrame: Baseline
measure: Parkinson's Disease Quality of Life-8
timeFrame: Baseline
measure: Hemogramme
timeFrame: Baseline
Secondary outcomes:
measure: Unified Parkinson's Disease Rating Scale
timeFrame: Baseline
measure: Tandem stance test:
timeFrame: Baseline
measure: Tandem walking test
timeFrame: Baseline
Other outcomes:
measure: Standardized Mini Mental Test
timeFrame: Baseline
measure: Modified Hoehn and Yahr Scale
timeFrame: Baseline
Locations:
city: Niğde
country: Turkey
facility: Nigde Omer Halisdemir University Treaning and Research Hospital
Study officials:
References: