Clinical trial NCT00965354: Mechanisms of Severe Acute Influenza Consortium (MOSAIC)
Official title: Mechanisms of Severe Acute Influenza Consortium (MOSAIC)
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Influenza
Keywords: severe
acute
influenza
consortium
swine
flu
influenza A
H1N1
hospital
admission
Lead sponsor: Imperial College London
Sponsor class: OTHER
Collaborators: name: Wellcome Trust
name: Medical Research Council
First posted: 2009-08-25
Enrollment: 131
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Hospital admissions

Brief summary: The ultimate goal of this collaborative, intensive study is to discover new and effective treatments and to develop better vaccines that can be used in future outbreaks of Influenza A. By integrating the information that we will gather, we will create a unique overview of how influenza causes illness and what might be done to improve patient management.

Detailed description: Influenza A is one of the best studied viruses, but continues to have a very large impact on human and animal health. In addition to causing outbreaks of winter flu, it sometimes mutates to create a new virus that spreads quickly around the world. It is puzzling that the same virus appears to cause minor or absent symptoms in some people while killing others. Much remains to be understood.

The investigators have assembled an unprecedented group of internationally renowned scientists from England and Scotland who will together focus on studying a few hundred people hospitalised during the current swine flu pandemic. Such a large scale project has never before been attempted, but we are now poised to work together and integrate the many recent advances in biomedical science that relate to understanding how influenza causes disease.

Eligibility criteria: Inclusion Criteria:

* Any patient admitted to hospital with suspected or confirmed influenza infection

Exclusion Criteria:

* Patients who do not give their consent

Primary outcomes:
measure: Number of Patients With Clinical Phenotype Presenting Also a Sequential Activation of Immune/Infammatory Pathways.
timeFrame: 15 months
Secondary outcomes:
Other outcomes:
Locations:
city: Liverpool
country: United Kingdom
facility: Alder Hey Children's Foundation NHS Trust
city: Liverpool
country: United Kingdom
facility: Royal Liverpool University Hospital
city: Liverpool
country: United Kingdom
facility: Liverpool Women's NHS Foundation Trust
city: Liverpool
country: United Kingdom
facility: Aintree Hospitals NHS Trust
city: London
country: United Kingdom
facility: Chelsea and Westminster Hospital NHS Foundation Trust
city: London
country: United Kingdom
facility: Royal Brompton and Harefield NHS Foundation Trust
city: London
country: United Kingdom
facility: Imperial College Healthcare NHS Trust
city: Wirral
country: United Kingdom
facility: Wirral University Teaching Hospital NHS Foundation Trust
Study officials:
affiliation: Imperial College London
name: Peter JM Openshaw
role: PRINCIPAL_INVESTIGATOR
References:
citation: Dunning J, Blankley S, Hoang LT, Cox M, Graham CM, James PL, Bloom CI, Chaussabel D, Banchereau J, Brett SJ, Moffatt MF, O'Garra A, Openshaw PJM; MOSAIC Investigators. Progression of whole-blood transcriptional signatures from interferon-induced to neutrophil-associated patterns in severe influenza. Nat Immunol. 2018 Jun;19(6):625-635. doi: 10.1038/s41590-018-0111-5. Epub 2018 May 18.
citation: Dunning J, Blankley S, Hoang LT, Cox M, Graham CM, James PL, Bloom CI, Chaussabel D, Banchereau J, Brett SJ; MOSAIC Investigators; Moffatt MF, O'Garra A, Openshaw PJM. Author Correction: Progression of whole-blood transcriptional signatures from interferon-induced to neutrophil-associated patterns in severe influenza. Nat Immunol. 2019 Mar;20(3):373. doi: 10.1038/s41590-019-0328-y.