Clinical trial NCT02805634: Correlation Between the 'Nine Holes Peg Test' Performance and the Triple Stimulation Technique Within a Group a Patients With Multiple Sclerosis
Official title: Correlation Between the 'Nine Holes Peg Test' Performance and the Triple Stimulation Technique Within a Group a Patients With Multiple Sclerosis
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Multiple Sclerosis
Keywords: nine holes peg
triple stimulation
multiple sclerosis
Lead sponsor: Brugmann University Hospital
Sponsor class: OTHER
First posted: 2016-06-20
Enrollment: 30
Sex: ALL
Minimum age (years): 20
Maximum age (years): 60
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: NON_RANDOMIZED
Intervention model: PARALLEL
Primary purpose: DIAGNOSTIC

Brief summary: The main goal of this study is to determine if the Triple Stimulation Technique (TST) can be correlated to performance in the manual dexterity 'nine holes peg' test, within a control group and a group of patients with multiple sclerosis.

TST (Triple stimulation technique) combines two techniques used in neurologic diagnosis: magnetic stimulation and electroneuromyography. It is based on the principle of two collisions between the descending central stimulation (magnetic stimulation) and the ascending peripheric stimulation. TST allows to better quantify central nervous system diseases. The abnormal amplitude registered by TST is proportional to the intensity of conduction disorders. The evaluation of these disorders is more precise than with the magnetic stimulation technique alone.

The Nine Hole Pegs technique is a simple manual dexterity test, commonly used in ergotherapy. The participant tries to place 9 pegs in a 9 holes perforated plate, and then tries to remove them as quickly as possible. The hand must stay in a depression within the plate, thereby insuring a constant distance between the hand and the pegs.

The nine hole peg will be realized first, and the triple stimulation examination performed after. The acquired data will be analyzed in order to find a correlation between the impairment level given by these two tests.


Eligibility criteria: Inclusion Criteria:

Control group:

* No history of neurological disease
* No medicines intake that could disturb performance within the tests (psychotropic medications, sedatives, anti spastic and drugs acting on neuromuscular transmission).

Multiple sclerosis group

* Multiple sclerosis diagnose. Patients followed by Dr Dachy, within the CHU Brugmann Hospital.

Exclusion Criteria:

* Persons carrying ferromagnetic material (implants, pacemaker).
* Epilepsy history.
* Patients who have had a head trauma with loss of consciousness and/or brain injury.
* Pregnant woman.

Primary outcomes:
measure: Amplitude of the motor evoked potentials
timeFrame: during the TST (30 min)
measure: Amplitude ratio of the TST
timeFrame: during the TST (30 min)
measure: Surface ratio of the TST
timeFrame: during the TST (30 min)
measure: Nine Holes Peg test result
timeFrame: Baseline
Secondary outcomes:
Other outcomes:
Locations:
city: Brussels
country: Belgium
facility: CHU Brugmann
Study officials:
affiliation: CHU Brugmann
name: Bernard Bernard, MD
role: PRINCIPAL_INVESTIGATOR
affiliation: CHU Brugmann
name: Pedro Calderon, MD
role: PRINCIPAL_INVESTIGATOR
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