Clinical trial NCT02091817: The Effect of Oxytocin on Face Perception
Official title: The Behavioral and Neural Effects of Oxytocin on Face Perception in Congenital Prosopagnosia
Study type: INTERVENTIONAL
Overall status: SUSPENDED
Phase: EARLY_PHASE1
Conditions: Healthy
Congenital Prosopagnosia
Keywords: oxytocin
face
memory
Lead sponsor: Soroka University Medical Center
Sponsor class: OTHER
Collaborators: name: Ben-Gurion University of the Negev
First posted: 2014-03-19
Enrollment: 100
Sex: ALL
Minimum age (years): 18
Maximum age (years): 80
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: CROSSOVER
Primary purpose: BASIC_SCIENCE

Brief summary: The purpose of this study is to determine whether oxytocin affect face perception


Eligibility criteria: Inclusion Criteria:

* normal or corrected to normal vision

Exclusion Criteria:

* minors
* pregnancy (according to a pregnancy test taken by subjects prior to participation)
* a history of asthma or nasal polyps
* cardiac disorders
* hyponatremia
* acute or chronic renal insufficiency
* liver cirrhosis
* neurological disease
* other chronic disease
* dementia, or lack of judgment

Primary outcomes:
measure: Memory performance
timeFrame: Day 2 (24 hours after encoding)
Secondary outcomes:
measure: Mood measurement
timeFrame: Day 1 (after oxytocin/placebo uptake)
Other outcomes:
Locations:
city: Beer Sheva
country: Israel
facility: Soroka medical center
Study officials:
affiliation: Soroka University Medical Center
name: Shelef Ilan, MD
role: PRINCIPAL_INVESTIGATOR
affiliation: Ben-Gurion University of the Negev
name: Galia Avidan, Ph.D
role: PRINCIPAL_INVESTIGATOR
References:
citation: Avidan G, Behrmann M. Functional MRI reveals compromised neural integrity of the face processing network in congenital prosopagnosia. Curr Biol. 2009 Jul 14;19(13):1146-50. doi: 10.1016/j.cub.2009.04.060. Epub 2009 May 28.
citation: Avidan G, Behrmann M. Implicit familiarity processing in congenital prosopagnosia. J Neuropsychol. 2008 Mar;2(1):141-64. doi: 10.1348/174866407x260180.
citation: Avidan G, Hasson U, Malach R, Behrmann M. Detailed exploration of face-related processing in congenital prosopagnosia: 2. Functional neuroimaging findings. J Cogn Neurosci. 2005 Jul;17(7):1150-67. doi: 10.1162/0898929054475145.
citation: Behrmann M, Avidan G, Marotta JJ, Kimchi R. Detailed exploration of face-related processing in congenital prosopagnosia: 1. Behavioral findings. J Cogn Neurosci. 2005 Jul;17(7):1130-49. doi: 10.1162/0898929054475154.
citation: Hasson U, Avidan G, Deouell LY, Bentin S, Malach R. Face-selective activation in a congenital prosopagnosic subject. J Cogn Neurosci. 2003 Apr 1;15(3):419-31. doi: 10.1162/089892903321593135.
citation: MacDonald E, Dadds MR, Brennan JL, Williams K, Levy F, Cauchi AJ. A review of safety, side-effects and subjective reactions to intranasal oxytocin in human research. Psychoneuroendocrinology. 2011 Sep;36(8):1114-26. doi: 10.1016/j.psyneuen.2011.02.015. Epub 2011 Mar 23.
citation: Avidan G, Tanzer M, Hadj-Bouziane F, Liu N, Ungerleider LG, Behrmann M. Selective dissociation between core and extended regions of the face processing network in congenital prosopagnosia. Cereb Cortex. 2014 Jun;24(6):1565-78. doi: 10.1093/cercor/bht007. Epub 2013 Jan 31.