Clinical trial NCT03057977: EMPagliflozin outcomE tRial in Patients With chrOnic heaRt Failure With Reduced Ejection Fraction (EMPEROR-Reduced)
Official title: A Phase III Randomised, Double-blind Trial to Evaluate Efficacy and Safety of Once Daily Empagliflozin 10 mg Compared to Placebo, in Patients With Chronic Heart Failure With Reduced Ejection Fraction (HFrEF)
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE3
Conditions: Heart Failure
Lead sponsor: Boehringer Ingelheim
Sponsor class: INDUSTRY
Collaborators: name: Eli Lilly and Company
First posted: 2017-02-20
Enrollment: 3730
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The aim of the study is to investigate the safety and efficacy of empagliflozin versus placebo on top of guideline-directed medical therapy in patients with heart failure with reduced ejection fraction.


Eligibility criteria: Inclusion criteria:

* Male or female patient age \>= 18 years at screening. For Japan only: Age \>= 20 years at screening
* Patients with chronic HF (Chronic Heart Failure) NYHA (New York Heart Association Classification) class II-IV and reduced EF (Ejection Fraction) (LVEF (Left Ventricular Ejection Fraction) \<=40%) and elevated NT-proBNP (N-terminal of the prohormone brain natriuretic peptide)

  * If EF \>= 36% to \<= 40%: NT-proBNP \>= 2500 pg/ml or patients without AF (atrial fibrillation/atrial flutter) and NT-proBNP \>= 5000 pg/ml for patients with AF
  * If EF \>= 31% to \<= 35%: NT-proBNP \>= 1000 pg/ml for patients without AF and NT-proBNP \>=2000 pg/ml for patients with AF
  * If EF\<= 30%: NT-proBNP \>= 600 pg/ml for patients without AF and NT-proBNP \>=1200 pg/ml for patients with AF
  * EF ≤ 40% and hospitalization for heart failure in the past 12 months: NTproBNP ≥ 600 pg/ml for patients without AF and NT-proBNP \>= 1200 pg/ml for patients with AF
* Appropriate dose of medical therapy for HF consistent with prevailing local and international CV (Cardiovascular) guidelines, stable for at least 1 week prior to Visit 1
* Appropriate use of medical devices such as cardioverter defibrillator (ICD) or a cardiac resynchronization therapy (CRT) consistent with prevailing local or international CV guidelines
* Signed and dated written ICF (Informed Consent Form)
* Further inclusion criteria apply

Exclusion criteria:

* Myocardial infarction, coronary artery bypass graft surgery, or other major cardiovascular surgery, stroke or TIA (Transient Ischaemic Attack) in past 90 days prior to Visit 1
* Heart transplant recipient, or listed for heart transplant
* Acute decompensated HF
* Systolic blood pressure (SBP) \>= 180 mmHg at Visit 2.
* Symptomatic hypotension and/or a SBP \< 100 mmHg
* Indication of liver disease
* Impaired renal function, defined as eGFR (Estimated Glomerular Filtration Rate) \< 20 mL/min/1.73 m2 (CKD-EPI (Chronic Kidney Disease - Epidemiology Collaboration Equation)) or requiring dialysis
* History of ketoacidosis
* Current use or prior use of a SGLT (Sodium-glucose co-transporter)-2 inhibitor or combined SGLT-1 and 2 inhibitor
* Currently enrolled in another investigational device or drug study
* Known allergy or hypersensitivity to empagliflozin or other SGLT-2 inhibitors
* Women who are pregnant, nursing, or who plan to become pregnant while in the trial
* Further exclusion criteria apply

Primary outcomes:
measure: Time to the First Event of Adjudicated Cardiovascular (CV) Death or Adjudicated Hospitalisation for Heart Failure (HHF)
timeFrame: From randomisation until completion of the planned treatment period, up to 1040 days.
Secondary outcomes:
measure: Occurrence of Adjudicated Hospitalisation for Heart Failure (HHF) (First and Recurrent)
timeFrame: From randomisation until completion of the planned treatment phase, up to 1040 days.
measure: eGFR (CKD-EPI) cr Slope of Change From Baseline
timeFrame: Assessed at baseline, week 4, 12, 32, 52, 76, 100, 124, 148 and at end of treatment (EOT), up to 1040 days.
measure: Time to First Event in Composite Renal Endpoint: Chronic Dialysis, Renal Transplant or Sustained Reduction of eGFR(CKD-EPI)cr
timeFrame: From randomisation until completion of the planned treatment period, up to 1040 days.
measure: Time to First Adjudicated Hospitalisation for Heart Failure (HHF)
timeFrame: From randomisation until completion of the planned treatment period, up to 1040 days.
measure: Time to Adjudicated Cardiovascular (CV) Death
timeFrame: From randomisation until completion of the planned treatment period, up to 1040 days.
measure: Time to All-cause Mortality
timeFrame: From randomisation until completion of the planned treatment period, up to 1040 days.
measure: Time to Onset of Diabetes Mellitus (DM)
timeFrame: From randomisation until completion of the planned treatment period, up to 1040 days.
measure: Change From Baseline in KCCQ (Kansas City Cardiomyopathy Questionnaire) Clinical Summary Score at Week 52
timeFrame: Assessed at baseline, week 12, week 32 and week 52.
measure: Number of All-cause Hospitalizations (First and Recurrent)
timeFrame: From randomisation until completion of the planned treatment phase, up to 1040 days.
Other outcomes:
Locations:
city: La Mesa
country: United States
facility: La Mesa Cardiac Center
state: California
city: Long Beach
country: United States
facility: Long Beach Center for Clinical Research
state: California
city: Los Angeles
country: United States
facility: VA Greater Los Angeles Healthcare System
state: California
city: Merced
country: United States
facility: Merced Vein and Vascular Center
state: California
city: Orange
country: United States
facility: University of California Irvine
state: California
city: Riverside
country: United States
facility: Covigilant Research, LLC
state: California
city: Torrance
country: United States
facility: University of California
state: California
city: Tustin
country: United States
facility: Orange County Research Center
state: California
city: Vista
country: United States
facility: Blue Coast Cardiology
state: California
city: Littleton
country: United States
facility: South Denver Cardiology Associates, PC
state: Colorado
city: Boca Raton
country: United States
facility: Integrated Heart Care
state: Florida
city: Clearwater
country: United States
facility: Morton Plant Mease Health Care
state: Florida
city: Crystal River
country: United States
facility: Nature Coast Clinical Research
state: Florida
city: DeLand
country: United States
facility: Avail Clinical Research, LLC
state: Florida
city: Fort Lauderdale
country: United States
facility: Holy Cross Hospital
state: Florida
city: Fort Lauderdale
country: United States
facility: Integrative Research Associates
state: Florida
city: Inverness
country: United States
facility: Nature Coast Clinical Research
state: Florida
city: Jacksonville
country: United States
facility: East Coast Institute for Research, LLC
state: Florida
city: Jacksonville
country: United States
facility: Jacksonville Center for Clinical Research
state: Florida
city: Miami
country: United States
facility: Cardiovascular Research Center of South Florida
state: Florida
city: Ormond Beach
country: United States
facility: Peninsula Research, Inc.
state: Florida
city: Pensacola
country: United States
facility: Cardiology Consultants, Inc
state: Florida
city: Sarasota
country: United States
facility: Sarasota Memorial Hospital
state: Florida
city: Atlanta
country: United States
facility: Grady Clinical Research Center
state: Georgia
city: Augusta
country: United States
facility: Augusta University
state: Georgia
city: Columbus
country: United States
facility: Columbus Regional Research Institute
state: Georgia
city: Lawrenceville
country: United States
facility: Cardiovascular Group PC
state: Georgia
city: Savannah
country: United States
facility: Meridian Clinical Research, LLC
state: Georgia
city: Arlington Heights
country: United States
facility: Northwest Heart Clinical Research, LLC
state: Illinois
city: Chicago
country: United States
facility: University of Chicago
state: Illinois
city: North Chicago
country: United States
facility: Captain James A. Lovell Federal Health Care Center
state: Illinois
city: Rockford
country: United States
facility: Rockford Cardiovascular Associates
state: Illinois
city: Elkhart
country: United States
facility: Midwest Cardiovascular Research and Education Foundation
state: Indiana
city: Indianapolis
country: United States
facility: St. Francis Medical Group-Indiana Heart Physicians, Inc
state: Indiana
city: Richmond
country: United States
facility: Reid Hospital
state: Indiana
city: South Bend
country: United States
facility: Beacon Medical Group Clinical Research
state: Indiana
city: Owensboro
country: United States
facility: Research Integrity, LLC
state: Kentucky
city: Alexandria
country: United States
facility: Cambridge Medical Trials
state: Louisiana
city: Covington
country: United States
facility: Louisiana Heart Center
state: Louisiana
city: Monroe
country: United States
facility: Clinical Trials of America, LLC
state: Louisiana
city: New Orleans
country: United States
facility: Tulane University Hospital and Clinic
state: Louisiana
city: Annapolis
country: United States
facility: Anne Arundel Medical Center
state: Maryland
city: Baltimore
country: United States
facility: Johns Hopkins University Hospital School of Medicine
state: Maryland
city: Baltimore
country: United States
facility: MedStar Health Research Institute
state: Maryland
city: Beltsville
country: United States
facility: Metropolitan Cardiovascular Consultants
state: Maryland
city: Towson
country: United States
facility: Spectrum Clinical Research
state: Maryland
city: Boston
country: United States
facility: Tufts Medical Center
state: Massachusetts
city: Great Barrington
country: United States
facility: East Mountain Medical Associates, PC
state: Massachusetts
city: Alpena
country: United States
facility: Alpena General Hospital
state: Michigan
city: Saint Paul
country: United States
facility: Regions Hospital
state: Minnesota
city: Saint Louis
country: United States
facility: Saint Louis University
state: Missouri
city: Saint Louis
country: United States
facility: SLHV
state: Missouri
city: Las Vegas
country: United States
facility: Palm Research Center
state: Nevada
city: Bridgewater
country: United States
facility: Advanced Heart Care, LLC
state: New Jersey
city: Bronx
country: United States
facility: Cardiac Care and Vascular Medicine, PLLC
state: New York
city: Cheektowaga
country: United States
facility: Trinity Medical WNY, PC
state: New York
city: Great Neck
country: United States
facility: Northwell Health
state: New York
city: Lake Success
country: United States
facility: Mount Sinai School of Medicine
state: New York
city: New York
country: United States
facility: St. Luke's Roosevelt Hospital
state: New York
city: New York
country: United States
facility: Harlem Cardiology
state: New York
city: Stony Brook
country: United States
facility: Stony Brook University Medical Center
state: New York
city: Asheville
country: United States
facility: Asheville Cardiology Associates
state: North Carolina
city: Burlington
country: United States
facility: Kernodle Clinic West
state: North Carolina
city: Chapel Hill
country: United States
facility: The University of North Carolina at Chapel Hill
state: North Carolina
city: Charlotte
country: United States
facility: Novant Health Heart and Vascular Institute
state: North Carolina
city: Durham
country: United States
facility: Duke University Medical Center
state: North Carolina
city: Gastonia
country: United States
facility: Clinical Research of Gastonia
state: North Carolina
city: Lenoir
country: United States
facility: Clinical Trials of America, Inc
state: North Carolina
city: Marion
country: United States
facility: Rama Research LLC
state: Ohio
city: Toledo
country: United States
facility: University of Toledo
state: Ohio
city: Oklahoma City
country: United States
facility: South Oklahoma Heart Research Group
state: Oklahoma
city: Doylestown
country: United States
facility: Doylestown Health Cardiology
state: Pennsylvania
city: York
country: United States
facility: York Hospital, WellSpan Health
state: Pennsylvania
city: Anderson
country: United States
facility: AnMed Health Clinical Research
state: South Carolina
city: Charleston
country: United States
facility: Ralph H. Johnson VA Medical Center
state: South Carolina
city: Columbia
country: United States
facility: Palmetto Health
state: South Carolina
city: Columbia
country: United States
facility: William Jennings Bryan Dorn VA Medical Center
state: South Carolina
city: Rock Hill
country: United States
facility: Clinical Research of Rock Hill
state: South Carolina
city: Spartanburg
country: United States
facility: Palmetto Research Center, LLC
state: South Carolina
city: Memphis
country: United States
facility: Methodist University Hospital
state: Tennessee
city: Dallas
country: United States
facility: Baylor Heart and Vascular Hospital
state: Texas
city: Dallas
country: United States
facility: Soltero Cardiovascular Research Center
state: Texas
city: Dallas
country: United States
facility: University of Texas Southwestern Medical Center
state: Texas
city: Fort Worth
country: United States
facility: University of North Texas Health Science Center
state: Texas
city: Houston
country: United States
facility: The Methodist Hospital
state: Texas
city: Plano
country: United States
facility: The Heart Hospital
state: Texas
city: Farmington
country: United States
facility: Alpine Research Organization
state: Utah
city: Chester
country: United States
facility: Cardiac Health Management Network, P.C.
state: Virginia
city: Richmond
country: United States
facility: Hunter Holmes McGuire VA Medical Center
state: Virginia
city: Roanoke
country: United States
facility: Roanoke Heart Institute PLC
state: Virginia
city: Salem
country: United States
facility: Salem VA Medical Center
state: Virginia
city: Marshfield
country: United States
facility: Marshfield Clinic
state: Wisconsin
city: Bahia Blanca
country: Argentina
facility: Hospital Interzonal General de Agudos Dr Jose Penna
city: Bahia Blanca
country: Argentina
facility: Hospital Italiano Regional del Sur, Bahia Blanca
city: Caba
country: Argentina
facility: CIPREC
city: Caba
country: Argentina
facility: Hospital Italiano de Buenos Aires
city: Ciudad Autonoma Buenos Aires
country: Argentina
facility: Consultorios Asociados de Endocrinología e Invest Clínica
city: Ciudad Autonoma Buenos Aires
country: Argentina
facility: Instituto Cardiovascular de Buenos Aires
city: Ciudad Autonoma Buenos Aires
country: Argentina
facility: CCBR - Buenos Aires - AR
city: Ciudad Autonoma de Bs As
country: Argentina
facility: Centro Médico Viamonte
city: Ciudad Autónoma de Bs As
country: Argentina
facility: Sanatorio Güemes
city: Ciudadela
country: Argentina
facility: Instituto Medico Elsa Perez SRL (IMEP)
city: Cordoba
country: Argentina
facility: Clínica Colombo
city: Cordoba
country: Argentina
facility: Instituto Médico DAMIC S.R.L.
city: Coronel Suarez
country: Argentina
facility: Clinica Coronel Suarez SA
city: Corrientes
country: Argentina
facility: Instituto de Cardiología de Corrientes
city: Córdoba
country: Argentina
facility: Sanatorio Mayo Privado SA
city: Córdoba
country: Argentina
facility: Centro de Investigaciones Clinicas Instituto del Corazon
city: Córdoba
country: Argentina
facility: Sanatorio Allende S.A.
city: Córdoba
country: Argentina
facility: Hospital Privado
city: La Plata
country: Argentina
facility: Hospital Italiano de La Plata
city: Mar del Plata
country: Argentina
facility: Centro de Investigaciones Médicas
city: Mar del Plata
country: Argentina
facility: Hospital Privado de Comunidad
city: Olivos
country: Argentina
facility: Clínica Olivos
city: Quilmes
country: Argentina
facility: CER Instituto Médico
city: Quilmes
country: Argentina
facility: Instituto de Investigaciones Clínicas de Quilmes
city: Rosario
country: Argentina
facility: Instituto de Investigaciones Clinicas de Rosario
city: Rosario
country: Argentina
facility: Instituto Medico Fundación Grupo Colaborativo Rosario
city: Rosario
country: Argentina
facility: Sanatorio Británico
city: Rosario
country: Argentina
facility: Sanatorio Plaza
city: Rosario
country: Argentina
facility: Sanatorio Parque
city: Rosario
country: Argentina
facility: Instituto CAICI
city: Salta
country: Argentina
facility: CORDIS S.A., Salta
city: Salta
country: Argentina
facility: Centro Cardiovascular Salta
city: San Martin
country: Argentina
facility: Corporacion Medica de Gral. San Martin S.A.
city: San Miguel de Tucumán
country: Argentina
facility: Investigaciones Clinicas Tucuman
city: San Miguel de Tucumán
country: Argentina
facility: CCBR Tucuman
city: San Vicente
country: Argentina
facility: Centro Medico Luquez
city: Santa Fe
country: Argentina
facility: Centro de Investigaciones Clínicas del Litoral
city: Santa Fé
country: Argentina
facility: Hospital "Dr. José Maria Cullen "
city: Tucumán
country: Argentina
facility: Instituto de Cardiología
city: Villa Luro
country: Argentina
facility: CEMEDIC - Centro de Especialidades Medicas
city: New Lambton Heights
country: Australia
facility: John Hunter Hospital
state: New South Wales
city: Milton
country: Australia
facility: CORE Research Group
state: Queensland
city: South Brisbane
country: Australia
facility: Mater Hospital Brisbane
state: Queensland
city: Ashford
country: Australia
facility: SA-Heart Ashford Specialist Centre
state: South Australia
city: Fullarton
country: Australia
facility: Heart and Vascular Research
state: South Australia
city: Epping
country: Australia
facility: The Northern Hospital
state: Victoria
city: Fitzroy
country: Australia
facility: St Vincent's Hospital Melbourne
state: Victoria
city: Geelong
country: Australia
facility: University Hospital Geelong
state: Victoria
city: Parkville
country: Australia
facility: Royal Melbourne Hospital
state: Victoria
city: Brugge
country: Belgium
facility: AZ Sint-Jan Brugge
city: Charleroi
country: Belgium
facility: C.H.U. de Charleroi
city: Dendermonde
country: Belgium
facility: AZ Sint-Blasius
city: Genk
country: Belgium
facility: Ziekenhuis Oost-Limburg - Campus Sint-Jan
city: Gent
country: Belgium
facility: AZ Sint-Lucas - Campus Sint Lucas
city: Gilly
country: Belgium
facility: Grand Hôpital de Charleroi
city: Hasselt
country: Belgium
facility: Jessa Ziekenhuis - Campus Virga Jesse
city: La Louvière
country: Belgium
facility: La Louvière - UNIV CHU Tivoli
city: Leuven
country: Belgium
facility: UZ Leuven
city: Mechelen
country: Belgium
facility: AZ Sint-Maarten
city: Belo Horizonte
country: Brazil
facility: Hospital Felicio Rocho
city: Belo Horizonte
country: Brazil
facility: Hospital Vera Cruz
city: Belo Horizonte
country: Brazil
facility: Cardresearch Cardiologia Assistencial e de Pesquisas Ltda
city: Brasília
country: Brazil
facility: CCBR - Brasília
city: Brasília
country: Brazil
facility: ICDF - Instituto de Cardiologia do Distrito Federal
city: Brasília
country: Brazil
facility: CECAP - Centro de Cardiologia Clínica
city: Campina Grande do Sul
country: Brazil
facility: Hospital Angelina Caron
city: Campinas
country: Brazil
facility: Centro Especializado em Cardiol Loema Instituto de Pesq Clin
city: Campinas
country: Brazil
facility: IPECC - Instituto de Pesquisa Clínica de Campinas
city: Campinas
country: Brazil
facility: CAEP - Centro Avançado de Estudos e Pesquisas Ltda.,Campinas
city: Canoas
country: Brazil
facility: Hospital Universitário
city: Caxias do Sul
country: Brazil
facility: IPCEM - Instituto de Pesquisa Clínica para Estudos Multicêntricos - Universidade de Caxias do Sul
city: Curitiba
country: Brazil
facility: Irmandade da Santa Casa de Misericórdia de Curitiba
city: Fortaleza
country: Brazil
facility: Hospital de Messejana Dr. Carlos Alberto Studart Gomes
city: Goiania
country: Brazil
facility: Barroso e Sebba Ltda
city: Goiânia
country: Brazil
facility: HC-UFG - Hospital das Clínicas da Universidade Federal de Goiás
city: Marília
country: Brazil
facility: ICM - Instituto do Coracao de Marilia
city: Passo Fundo
country: Brazil
facility: Hospital São Vicente de Paulo
city: Porto Alegre
country: Brazil
facility: Santa Casa de Misericórdia de Porto Alegre
city: Porto Alegre
country: Brazil
facility: Centro de Pesquisas em Diabetes
city: Porto Alegre
country: Brazil
facility: Hospital de Clínicas de Porto Alegre
city: Porto Alegre
country: Brazil
facility: Instituto de Cardiologia Rio Grande do Sul
city: Recife
country: Brazil
facility: Hospital Agamenon Magalhaes
city: Ribeirão Preto
country: Brazil
facility: H.C.da Fac. de Medicina de Ribeirao Preto
city: Rio De Janeiro - RJ
country: Brazil
facility: Hospital Universitário Pedro Ernesto UERJ
city: Rio de Janeiro
country: Brazil
facility: CCBR - Rio de Janeiro - BR
city: Santo André
country: Brazil
facility: Pesquisare
city: Santo André
country: Brazil
facility: Praxis Pesquisa Médica
city: Sao Jose do Rio Preto
country: Brazil
facility: Fundacao Faculdade Regional de Medicina, Sao Jose
city: Sao Paulo
country: Brazil
facility: Centro de Pesquisa Clinica - CPCLIN
city: Sao Paulo
country: Brazil
facility: FGM - Clínica Paulista de Doenças Cardiovasculares
city: Sao Paulo
country: Brazil
facility: CEPIC - Centro Paulista de Investigacao Clinica
city: Sao Paulo
country: Brazil
facility: INCOR e Hospital das Clínicas da Universidade de São Paulo
city: São Bernardo do Campo
country: Brazil
facility: CEMEC - Centro Multidisciplinar de Estudos Clínicos
city: São Paulo
country: Brazil
facility: CDEC BRASIL - Centro de Desenvolvimento em Estudos Clínicos Brasil
city: São Paulo
country: Brazil
facility: Dr. Consulta
city: Vitória
country: Brazil
facility: CEDOES - Diagnóstico e Pesquisa,Vitória
city: Votuporanga
country: Brazil
facility: Santa Casa de Votuporanga
city: Edmonton
country: Canada
facility: Royal Alexandra Hospital
state: Alberta
city: Vancouver
country: Canada
facility: Vancouver General Hospital
state: British Columbia
city: Vancouver
country: Canada
facility: St. Paul's Hospital
state: British Columbia
city: Victoria
country: Canada
facility: Victoria Heart Institute Foundation
state: British Columbia
city: Winnipeg
country: Canada
facility: St. Boniface General Hospital
state: Manitoba
city: Moncton
country: Canada
facility: G.A. Research Associates Ltd
state: New Brunswick
city: Halifax
country: Canada
facility: QEII Health Sciences Centre
state: Nova Scotia
city: Brampton
country: Canada
facility: Brampton Cardio Pulmonary Clinic
state: Ontario
city: Burlington
country: Canada
facility: JBN Medical Diagnostic Services Inc.
state: Ontario
city: Cambridge
country: Canada
facility: Cambridge Cardiac Care Inc.
state: Ontario
city: Hamilton
country: Canada
facility: Curnew Medicine Professional Corporation
state: Ontario
city: Hamilton
country: Canada
facility: Hamilton General Hospital
state: Ontario
city: Newmarket
country: Canada
facility: Southlake Regional Health Centre
state: Ontario
city: Oakville
country: Canada
facility: M Heffernan Medicine Professional Corp.
state: Ontario
city: Peterborough
country: Canada
facility: Kawartha Cardiology Clinical Trials
state: Ontario
city: Scarborough
country: Canada
facility: Heart Health Institute
state: Ontario
city: Scarborough
country: Canada
facility: Scarborough Cardiology Research
state: Ontario
city: Sudbury
country: Canada
facility: Health Sciences North
state: Ontario
city: Toronto
country: Canada
facility: Canadian Phase Onward Inc.
state: Ontario
city: Toronto
country: Canada
facility: North York Diagnostic and Cardiac Centre
state: Ontario
city: Toronto
country: Canada
facility: Diabetes Heart Research Centre
state: Ontario
city: Waterloo
country: Canada
facility: Mohan Babapulle Medicine Professional Medicine
state: Ontario
city: York
country: Canada
facility: Dr. Louis C.H. Yao
state: Ontario
city: Greenfield Park
country: Canada
facility: ViaCar Recherche Clinique Inc
state: Quebec
city: Longeuil
country: Canada
facility: Centre de Dépistage et Recherche Cardiovasculaire Rive-Sud
state: Quebec
city: Montreal
country: Canada
facility: Clinique Santé Cardio MC
state: Quebec
city: Montreal
country: Canada
facility: Montreal General Hospital - McGill University Health Centre
state: Quebec
city: Montreal
country: Canada
facility: McGill University Health Centre (MUHC)
state: Quebec
city: Saint George-de-Beauce
country: Canada
facility: Centre de sante et de services sociaux de Beauce
state: Quebec
city: Quebec
country: Canada
facility: IUCPQ (Laval University)
city: Beijing
country: China
facility: Cardiovascular Institute and Fu Wai Hospital
city: Beijing
country: China
facility: Beijing Friendship Hospital
city: Changchun
country: China
facility: First Hospital of Jilin University
city: Changsha
country: China
facility: Hunan Provincial People's Hospital
city: Changsha
country: China
facility: 2nd Xiangya Hospital of Central South University
city: Changsha
country: China
facility: The Third Hospital of Changsha
city: Dongguan
country: China
facility: Dongguan People's Hospital
city: Fuzhou
country: China
facility: The First Affiliated Hospital of Fujian Medical University
city: Guangzhou
country: China
facility: The First Afiliated Hospital, Sun Yet-sen University
city: Guangzhou
country: China
facility: Guangzhou First Municipal People's Hospital
city: Haikou
country: China
facility: Haikou People's Hospital
city: Haikou
country: China
facility: HaiNan Provincial People's Hospital
city: Lanzhou
country: China
facility: The First Affiliated Hospital of Lanzhou University
city: Lanzhou
country: China
facility: The Second Affiliated Hospital of Lanzhou Medical University
city: Luzhou
country: China
facility: The Affiliated Hospital of Southwest Medical University
city: Nanchang
country: China
facility: Nanchang University Affiliated 3rd Hospital
city: Nanjing
country: China
facility: First Hospital Affiliated with Nanjing Medical University
city: Shanghai
country: China
facility: Huashan Hospital, Fudan University
city: Shenyang
country: China
facility: General Hospital of Shenyang Military Region
city: Shenyang
country: China
facility: Shengjing Hospital of China Medical University
city: Tianjin
country: China
facility: Tianjin Union Medical Center Nankai University Affiliated Hospital
city: Wuhan
country: China
facility: Tongji Hospital, Tongji University
city: Wuhan
country: China
facility: Renmin Hospital of Wuhan University
city: Xi'an
country: China
facility: First Affiliated Hospital of Xi'an JiaoTong University
city: Yanji
country: China
facility: Yanbian University Hospital
city: Yueyang
country: China
facility: the first people hospital of Yue Yang
city: Zhenjiang
country: China
facility: Affiliated Hospital of Jiangsu University
city: Bilovec
country: Czechia
facility: Poliklinika Humanitas
city: Brandys Nad
country: Czechia
facility: Medicus Services Ltd.
city: Brno
country: Czechia
facility: Internal and Cardiology Practice, MUDr. Karel Kamenik, Brno
city: Brno
country: Czechia
facility: MUDr. Alexandra Ludkova
city: Brno
country: Czechia
facility: Vojenska nemocnice Brno
city: Brno
country: Czechia
facility: Nemocnice Milosrdnych bratri
city: Broumov
country: Czechia
facility: Edumed s.r.o
city: Chrudim
country: Czechia
facility: MUDr. Jan Hubac, s.r.o. Kardiologicka ambulance
city: Frydek-Mistek
country: Czechia
facility: Nemocnice ve Frydku-Mistku, prispevkova organizace
city: Louny
country: Czechia
facility: MUDr. Ladislav Busak
city: Olomouc
country: Czechia
facility: Zdenek Vomacka
city: Pardubice
country: Czechia
facility: PV-Kardiologie s.r.o.
city: Prag 5
country: Czechia
facility: University Hospital Motol
city: Prague 2
country: Czechia
facility: General Faculty Hospital, Prague
city: Praha 4 - Krc
country: Czechia
facility: Thomayer Hospital
city: Prerov
country: Czechia
facility: Kardio Vaclavik s.r.o.
city: Pribram
country: Czechia
facility: Clinic of Cardiology, Pribram
city: Trebic
country: Czechia
facility: Hospital Trebic, p.o.
city: Usti nad Labem
country: Czechia
facility: Masaryk Hospital, Usti nad Labem
city: Zlin
country: Czechia
facility: Angiocor s.r.o
city: Znojmo
country: Czechia
facility: KIGE s.r.o
city: Bayonne
country: France
facility: HOP de Bayonne
city: Besançon
country: France
facility: HOP Jean Minjoz
city: Bron
country: France
facility: HOP Louis Pradel
city: Caen
country: France
facility: HOP Côte de Nacre
city: Montpellier
country: France
facility: HOP Arnaud de Villeneuve
city: Paris
country: France
facility: HOP La Pitié Salpêtrière
city: Pau
country: France
facility: Centre Hospitalier de Pau
city: Pessac
country: France
facility: HOP Haut-Lévêque
city: Toulouse
country: France
facility: HOP Rangueil
city: Vandoeuvre-lès-Nancy
country: France
facility: INS Louis Mathieu
city: Aachen
country: Germany
facility: Universitätsklinikum Aachen, AöR
city: Berlin
country: Germany
facility: Praxis Dr. Rieker, Berlin
city: Berlin
country: Germany
facility: Charité - Universitätsmedizin Berlin
city: Berlin
country: Germany
facility: Vivantes Netzwerk für Gesundheit GmbH
city: Berlin
country: Germany
facility: Charité - Universitätsmedizin Berlin
city: Bielefeld
country: Germany
facility: Klinikum Bielefeld gGmbH
city: Dessau-Roßlau
country: Germany
facility: Praxis Dr. Menzel
city: Dortmund
country: Germany
facility: St. Johannes Hospital Dortmund
city: Dresden
country: Germany
facility: Städtisches Klinikum Dresden
city: Dresden
country: Germany
facility: GWT-TUD GmbH
city: Erfurt
country: Germany
facility: Helios Klinikum Erfurt
city: Essen
country: Germany
facility: Studienzentrum Bocholderstraße
city: Frankfurt
country: Germany
facility: ClinPhenomics GmbH & Co KG, Frankfurt
city: Göttingen
country: Germany
facility: Universitätsmedizin Göttingen, Georg-August-Universität
city: Hamburg
country: Germany
facility: Asklepios Klinik St. Georg
city: Hannover
country: Germany
facility: Medizinische Hochschule Hannover
city: Heidelberg
country: Germany
facility: Universitätsklinikum Heidelberg
city: Homburg
country: Germany
facility: Universitätsklinikum des Saarlandes
city: Jena
country: Germany
facility: Universitätsklinikum Jena
city: Kiel
country: Germany
facility: Universitätsklinikum Schleswig-Holstein, Campus Kiel
city: Langen
country: Germany
facility: Asklepios Klinik Langen-Seligenstadt GmbH
city: Lüdenscheid
country: Germany
facility: Märkische Gesundheitsholding GmbH & Co. KG, Klinikum Lüdenscheid
city: Lüneburg
country: Germany
facility: Praxis Dr. Sarnighausen, Lüneburg
city: Mainz
country: Germany
facility: Katholisches Klinikum St. Hildegardiskrankenhaus, Mainz
city: München
country: Germany
facility: Deutsches Herzzentrum München
city: Nienburg
country: Germany
facility: Kardiologische Gemeinschaftspraxis Nienburg
city: Papenburg
country: Germany
facility: Kardiologische Praxis Papenburg
city: Regensburg
country: Germany
facility: Universitätsklinikum Regensburg
city: Riesa
country: Germany
facility: Praxis Dr. Stenzel, Riesa
city: Wangen
country: Germany
facility: Zentrum für Klinische Forschung
city: Warendorf
country: Germany
facility: Josephs-Hospital Warendorf
city: Wuppertal
country: Germany
facility: Petrus-Krankenhaus
city: Baja
country: Hungary
facility: Lausmed Kft. Outpatient Unit of Internal Medicine
city: Bekescsaba
country: Hungary
facility: Belgyogyaszati es Kardiologiai Maganrendelo
city: Budapest
country: Hungary
facility: Clinexpert Kft.
city: Budapest
country: Hungary
facility: Gottsegen Gyorgy Hungarian Instit.of Cardiology,Budapest
city: Budapest
country: Hungary
facility: Bajcsy-Zsilinszky Hospital and Clinic
city: Budapest
country: Hungary
facility: Semmelweis University
city: Budapest
country: Hungary
facility: Milit.Hosp.-State Health Cent.
city: Budapest
country: Hungary
facility: Uzsoki Street Hospital, Budapest
city: Debrecen
country: Hungary
facility: Nehezlegzes Ambulancia
city: Gyongyos
country: Hungary
facility: Bugat Pal Hospital, Gyongyos
city: Komarom
country: Hungary
facility: Selye Janos Hospital Komarom
city: Nagykanizsa
country: Hungary
facility: Dorottya Kanizsai Hospital
city: Oroshaza
country: Hungary
facility: Dr. Nagy Laszlo Kardiologiai Maganrendeles
city: Pecs
country: Hungary
facility: Da Vinci Maganklinika
city: Pécs
country: Hungary
facility: Pecsi Tudomanyegyetem
city: Szekesfehervar
country: Hungary
facility: Fejer County Saint George University Teaching Hospital
city: Veszprem
country: Hungary
facility: Veszpremi Sziv es Egeszseg Centrum
city: Ahmedabad
country: India
facility: Doctor Jivraj Mehta Smarak Health Foundation
city: Aurangabad
country: India
facility: Kamalnayan Bajaj Hospital
city: Bangalore
country: India
facility: Narayana Institute of Cardiac Sciences
city: Bengaluru
country: India
facility: Rajarajeswari Medical College
city: Chennai
country: India
facility: Madras Medical Mission,
city: Chennai
country: India
facility: Apollo Speciality Hospital
city: Gurgaon
country: India
facility: Medanta-The Medicity
city: Kolkatta
country: India
facility: B.M. Birla Heart research Centre
city: Nashik
country: India
facility: Siddhi Hospital
city: Nasik
country: India
facility: Vijan Cardiac and Critical Care Centre
city: New Delhi
country: India
facility: Batra Hospital and Medical Research Centre
city: New Delhi
country: India
facility: GB Pant Hospital
city: New Delhi
country: India
facility: Fortis Escorts Heart Institute
city: New Delhi
country: India
facility: Sir Gangaram Hospital
city: Benevento
country: Italy
facility: Azienda Ospedaliera G. Rummo
city: Bergamo
country: Italy
facility: ASST Papa Giovanni XXIII - A.O. Papa Giovanni XXIII
city: Cona (FE)
country: Italy
facility: Azienda Ospedaliera Universitaria Arcispedale Sant'Anna
city: Cortona (AR)
country: Italy
facility: Ospedale della Val di Chiana Santa Margherita
city: Milano
country: Italy
facility: Centro Cardiologico Monzino-IRCCS
city: Napoli
country: Italy
facility: Azienda Ospedaliera Universitaria "Federico II"
city: Pisa
country: Italy
facility: Azienda Ospedaliera Universitaria Pisana
city: Roma
country: Italy
facility: Umberto I Pol. di Roma-Università di Roma La Sapienza
city: Roma
country: Italy
facility: Azienda Ospedaliera Sant'Andrea-Università di Roma La Sapienza
city: Trieste
country: Italy
facility: Azienda Servizi Sanitari 1 Triestina
city: Aichi, Kasugai
country: Japan
facility: Kasugai Municipal Hospital
city: Aichi, Nagoya
country: Japan
facility: Nagoya Kyoritsu Hospital
city: Aichi, Nagoya
country: Japan
facility: Japanese Red Cross Nagoya Daini Hospital
city: Aichi, Toyota
country: Japan
facility: Toyota Memorial Hospital
city: Chiba, Chiba
country: Japan
facility: Chiba Heart Clinic
city: Chiba, Kisarazu
country: Japan
facility: Kimitsu Chuo Hospital
city: Chiba, Matsudo
country: Japan
facility: Seikeikai New Tokyo Heart Clinic
city: Ehime, Matsuyama
country: Japan
facility: Ehime Prefectural Central Hospital
city: Ehime, Matsuyama
country: Japan
facility: Matsuyama Shimin Hospital
city: Ehime, Uwajima
country: Japan
facility: Uwajima City Hospital
city: Fukui, Fukui
country: Japan
facility: Fukuiken Saiseikai Hospital
city: Fukuoka, Chikushino
country: Japan
facility: Fukuoka University Chikushi Hospital
city: Fukuoka, Chikushino
country: Japan
facility: Fukuokaken Saiseikai Futsukaichi Hospital
city: Fukuoka, Fukuoka
country: Japan
facility: Saiseikai Fukuoka General Hospital
city: Fukuoka, Fukuoka
country: Japan
facility: National Hospital Organization Kyushu Medical Center
city: Fukuoka, Fukuoka
country: Japan
facility: Kyushu University Hospital
city: Fukuoka, Iizuka
country: Japan
facility: Aso Co.,Ltd Iizuka Hospital
city: Fukuoka, Kitakyushu
country: Japan
facility: Steel Memorial Yawata Hospital
city: Fukuoka, Kitakyushu
country: Japan
facility: Japan Community Health Care Organization Kyushu Hospital
city: Gifu, Ogaki
country: Japan
facility: Ogaki Municipal Hospital
city: Gifu, Seki
country: Japan
facility: Chuno Kosei Hospital
city: Hiroshima, Fukuyama
country: Japan
facility: Fukuyama City Hospital
city: Hiroshima, Hatsukaichi
country: Japan
facility: JA Hiroshima General Hospital
city: Hiroshima, Shobara
country: Japan
facility: Shobara Red Cross Hospital
city: Hokkaido, Hakodate
country: Japan
facility: National Hospital Organization Hakodate Hospital
city: Hokkaido, Sapporo
country: Japan
facility: Teine Keijinkai Clinic
city: Hokkaido, Tomakomai
country: Japan
facility: Tomakomai City Hospital
city: Hyogo, Amagasaki
country: Japan
facility: Hyogo Prefectural Amagasaki General Medical Center
city: Hyogo, Himeji
country: Japan
facility: Hyogo Brain and Heart Center
city: Hyogo, Kobe
country: Japan
facility: National Hospital Organization Kobe Medical Center
city: Ibaraki, Higashiibaraki-gun
country: Japan
facility: Mito Medical Center
city: Ishikawa, Kanazawa
country: Japan
facility: National Hospital Organization Kanazawa Medical Center
city: Kagawa, Kanonji
country: Japan
facility: Mitoyo General Hospital
city: Kagawa, Takamatsu
country: Japan
facility: Kagawa Prefectural Central Hospital
city: Kanagawa, Sagamihara
country: Japan
facility: Yamamoto Clinic
city: Kanagawa, Yokohama
country: Japan
facility: Kanagawa Cardiovascular and Respiratory Center
city: Kumamoto, Kumamoto
country: Japan
facility: Japanese Red Cross Kumamoto Hospital
city: Kumamoto, Kumamoto
country: Japan
facility: Seiwakai Suizenji Touya Hospital
city: Kumamoto, Yatsushiro
country: Japan
facility: Kumamoto Rosai Hospital
city: Kyoto, Uji
country: Japan
facility: Uji-Tokushukai Medical Center
city: Miyagi, Sendai
country: Japan
facility: Sendai Kousei Hospital
city: Miyagi, Sendai
country: Japan
facility: Sendai Tokushukai Hospital
city: Miyagi, Sendai
country: Japan
facility: The Cardiovascular Center of Sendai
city: Miyagi, Sendai
country: Japan
facility: National Hospital Organization Sendai Medical Center
city: Miyazaki, Miyazaki
country: Japan
facility: Miyazaki Medical Association Hospital
city: Nagano, Nakano
country: Japan
facility: Hokushin General Hospital
city: Nagasaki, Omura
country: Japan
facility: Nagasaki Medical Center
city: Okayama, Okayama
country: Japan
facility: Okayama City General Medical Center
city: Okinawa, Naha
country: Japan
facility: Naha City Hospital
city: Okinawa, Shimajiri-gun
country: Japan
facility: Nanbu Tokushukai Hospital
city: Okinawa, Urasoe
country: Japan
facility: Urasoe General Hospital
city: Osaka, Higashiosaka
country: Japan
facility: Higashiosaka City Medical Center
city: Osaka, Osaka
country: Japan
facility: Kitano Hospital
city: Osaka, Osaka
country: Japan
facility: Yodogawa Christian Hospital
city: Osaka, Sakai
country: Japan
facility: Seichokai Bell Land General Hospital
city: Osaka, Takatsuki
country: Japan
facility: Hokusetsu General Hospital
city: Saitama, Saitama
country: Japan
facility: San-Ai Hospital
city: Saitama, Saitama
country: Japan
facility: Kosekai Iwatsuki-minami Hospital
city: Shiga, Kusatsu
country: Japan
facility: Kusatsu General Hospital
city: Tokushima, Tokushima
country: Japan
facility: Tokushima Prefectural Central Hospital
city: Tokyo, Meguro-ku
country: Japan
facility: National Hospital Organization Tokyo Medical Center
city: Tokyo, Ome
country: Japan
facility: Ome Municipal General Hospital
city: Tokyo, Ota-ku
country: Japan
facility: Tokyo Rosai Hospital
city: Tokyo, Toshima-ku
country: Japan
facility: Sekino Hospital
city: Wakayama, Tanabe
country: Japan
facility: Minami Wakayama Medical Center
city: Yamaguchi, Shimonoseki
country: Japan
facility: Kanmon Medical Center
city: Busan
country: Korea, Republic of
facility: Dong-A University Hospital
city: Busan
country: Korea, Republic of
facility: Inje University Busan Paik Hospital
city: Cheongju
country: Korea, Republic of
facility: Chungbuk National University Hospital
city: Daejeon
country: Korea, Republic of
facility: Chungnam National University Hospital
city: Incheon
country: Korea, Republic of
facility: Gachon University Gil Medical Center
city: Seoul
country: Korea, Republic of
facility: Seoul National University Hospital
city: Seoul
country: Korea, Republic of
facility: Severance Hospital
city: Seoul
country: Korea, Republic of
facility: Asan Medical Center
city: Seoul
country: Korea, Republic of
facility: Samsung Medical Center
city: Seoul
country: Korea, Republic of
facility: Korea University Guro Hospital
city: Sungnam
country: Korea, Republic of
facility: Seoul National University Bundang Hospital
city: Wonju
country: Korea, Republic of
facility: Wonju Severance Christian Hosp
city: Aguascalientes
country: Mexico
facility: Hospital Cardiologica Aguascalientes
city: Ciudad de Mexico
country: Mexico
facility: Instituto Nacional de Cardiologia Ignacio Chavez
city: Distrito Federal
country: Mexico
facility: Centro de Investigacion Biomedica y Farmaceutica, S.C.
city: Guadalajara
country: Mexico
facility: Unidad de Investigacion Clinica Cardiometabolica de Occident
city: Guadalajara
country: Mexico
facility: Diseño y Planeación en Investigación Médica SC
city: Guadalajara
country: Mexico
facility: Cardiologia Clinica e Intervencionista
city: Mexico
country: Mexico
facility: Centro de Investigación Clinica Acelerada, S.C.
city: Monclova
country: Mexico
facility: Instituto Cardiovascular de Monclova, S de RL de CV
city: México
country: Mexico
facility: CEDOPEC-Ctro Esp en Diab, Obesidad y Prev de Enf Cardiovasc
city: Nuevo Leon
country: Mexico
facility: Hospital Universitario Dr Jose Eleuterio Gonzalez
city: San Juan del Rio
country: Mexico
facility: Centro Integral Medico SJR S.C.
city: San Luis Potosi
country: Mexico
facility: Cardioarritmias e Investigación S.C
city: Tijuana
country: Mexico
facility: Centro de Investigacion Cardiovascular y Metabolica
city: Torreon
country: Mexico
facility: Centro de Investigacion Medica Alberto Bazzoni S.A. de C.V.
city: Zapopan
country: Mexico
facility: Hospital Dr Angel Leano
city: Almelo
country: Netherlands
facility: Ziekenhuisgroep Twente locatie Almelo
city: Amsterdam
country: Netherlands
facility: BovenIJ Ziekenhuis
city: Amsterdam
country: Netherlands
facility: Onze Lieve Vrouwe Gasthuis, Locatie West
city: Amsterdam
country: Netherlands
facility: Amsterdam UMC Locatie VUMC
city: Amsterdam
country: Netherlands
facility: Onze Lieve Vrouwe Gasthuis
city: Amsterdam
country: Netherlands
facility: Amsterdam UMC, Locatie AMC
city: Beverwijk
country: Netherlands
facility: Rode Kruis Ziekenhuis Beverwijk
city: Blaricum
country: Netherlands
facility: Tergooiziekenhuizen locatie Blaricum
city: Breda
country: Netherlands
facility: Amphia Ziekenhuis
city: Den Haag
country: Netherlands
facility: HMC Bronovo
city: EDE
country: Netherlands
facility: Ziekenhuis Gelderse Vallei
city: Eindhoven
country: Netherlands
facility: Catharina Ziekenhuis
city: Groningen
country: Netherlands
facility: Universitair Medisch Centrum Groningen
city: Heerlen
country: Netherlands
facility: Zuyderland Medisch Centrum
city: Hoorn
country: Netherlands
facility: Vasculair Onderzoek Centrum
city: Maastricht
country: Netherlands
facility: Maastricht Universitair Medisch Centrum
city: Meppel
country: Netherlands
facility: Diaconessenhuis Meppel
city: Nieuwegein
country: Netherlands
facility: St. Antonius ziekenhuis, locatie Nieuwegein
city: Nijmegen
country: Netherlands
facility: Radboud Universitair Medisch Centrum
city: Uden
country: Netherlands
facility: Ziekenhuis Bernhoven Uden
city: Venlo
country: Netherlands
facility: Vie Curi Medisch Centrum
city: Zaandam
country: Netherlands
facility: De Heel - Zaans Medisch Centrum
city: Zutphen
country: Netherlands
facility: Gelre Ziekenhuis Zutphen
city: Bialystok
country: Poland
facility: KLIMED Marek Klimkiewicz
city: Bialystok
country: Poland
facility: Univ. Clinic Hosp, Bialystok
city: Bielsko-Biala
country: Poland
facility: American Heart of Poland Sp. z o.o.
city: Bydgoszcz
country: Poland
facility: NZOZ Centrum Medyczne KERmed
city: Chorzow
country: Poland
facility: Polsko-Amerykanskie Kliniki Serca
city: Dabrowa Gornicza
country: Poland
facility: American Heart of Poland Sp. z o.o.
city: Gdansk
country: Poland
facility: Poradnia Kardiologiczna Jaroslaw Jurowiecki
city: Gdansk
country: Poland
facility: University Clinical Center, Gdansk
city: Gdynia
country: Poland
facility: Indywidualna Specjalistyczna Praktyka Lekarska
city: Gdynia
country: Poland
facility: Saint Wincenty a Paulo Hosp., Cardiology Dept., Gdynia
city: Katowice
country: Poland
facility: Szpital Zakonu Bonifratow Sp. z o.o.
city: Kielce
country: Poland
facility: Specialistic Cardiology&Hypertension Out-patient Clin,Kielce
city: Krakow
country: Poland
facility: Leszek Bryniarski Specialized Medical Cabinet
city: Krakow
country: Poland
facility: Krakow Specialistic Hospital of John Paul II
city: Lodz
country: Poland
facility: SANTA FAMILIA Centrum Badan, Profilaktyki i Leczenia
city: Lodz
country: Poland
facility: Nzoz Salus
city: Lodz
country: Poland
facility: Individual Specialized Practice
city: Lowicz
country: Poland
facility: Lowickie Cardiology Center
city: Nysa
country: Poland
facility: American Heart of Poland Sp. z o.o.
city: Oswiecim
country: Poland
facility: Medicome Sp. z o.o.
city: Ruda Slaska
country: Poland
facility: Specialized Practice Dr. Janusz Spyra
city: Rzeszow
country: Poland
facility: Centrum Medyczne Medyk
city: Siedlce
country: Poland
facility: Lukmed Lukasz Wozniak
city: Skierniewice
country: Poland
facility: Clinmedica Research Omc sp. z o.o. sp.k., Skierniewice
city: Staszow
country: Poland
facility: KO-MED Centra Kliniczne Staszow
city: Torun
country: Poland
facility: The Provincial Polyclinical Hospital in Torun
city: Tychy
country: Poland
facility: American Heart of Poland Sp. z o.o.
city: Ustron
country: Poland
facility: American Heart of Poland Sp. z o.o.
city: Warsaw
country: Poland
facility: Central Hospital of Medical Academy, Warsaw
city: Warszawa
country: Poland
facility: McM Polimedica
city: Wroclaw
country: Poland
facility: 4. Military Clinical Hospital with Polyclinic SP ZOZ
city: Zgierz
country: Poland
facility: Zgierskie Center of Cardiology MED-PRO
city: Zychlin
country: Poland
facility: Specialist Hospital J. Dietla NZOZ Specialized Clinic "Gemini"
city: Barcelona
country: Spain
facility: Hospital Quiron. I.C.U.
city: Barcelona
country: Spain
facility: Hospital Santa Creu i Sant Pau
city: El Palmar
country: Spain
facility: Hospital Universitario Virgen de la Arrixaca
city: L'Hospitalet de Llobregat
country: Spain
facility: Hospital de Bellvitge
city: Madrid
country: Spain
facility: Hospital Ramón y Cajal
city: Madrid
country: Spain
facility: Hospital Clínico San Carlos
city: Madrid
country: Spain
facility: Hospital Universitario 12 de Octubre
city: Madrid
country: Spain
facility: Hospital La Paz
city: Malaga
country: Spain
facility: Hospital Virgen de la Victoria
city: Orense
country: Spain
facility: Complejo Hospitalario Universitario de Orense
city: Santiago de Compostela
country: Spain
facility: Hospital Clínico de Santiago
city: Valladolid
country: Spain
facility: Hospital Clínico Universitario de Valladolid
city: Barnet
country: United Kingdom
facility: Barnet General Hospital
city: Cardiff
country: United Kingdom
facility: University Hospital of Wales
city: Eastleigh
country: United Kingdom
facility: Park & St Francis Surgery
city: High Wycombe
country: United Kingdom
facility: Wycombe General Hospital
city: Leicester
country: United Kingdom
facility: Glenfield Hospital
city: London
country: United Kingdom
facility: St Bartholomew's Hospital
city: Luton
country: United Kingdom
facility: Luton and Dunstable University Hospital
city: Newport
country: United Kingdom
facility: St Mary's Hospital
city: Swansea
country: United Kingdom
facility: Morriston Hospital
Study officials:
affiliation: Boehringer Ingelheim
name: Boehringer Ingelheim
role: STUDY_CHAIR
References:
citation: Ferreira JP, Zannad F, Butler J, Filippatos G, Pocock SJ, Brueckmann M, Steubl D, Schueler E, Anker SD, Packer M. Association of Empagliflozin Treatment With Albuminuria Levels in Patients With Heart Failure: A Secondary Analysis of EMPEROR-Pooled. JAMA Cardiol. 2022 Nov 1;7(11):1148-1159. doi: 10.1001/jamacardio.2022.2924.
citation: Ferreira JP, Zannad F, Butler J, Filipattos G, Ritter I, Schuler E, Kraus BJ, Pocock SJ, Anker SD, Packer M. Empagliflozin and serum potassium in heart failure: an analysis from EMPEROR-Pooled. Eur Heart J. 2022 Aug 14;43(31):2984-2993. doi: 10.1093/eurheartj/ehac306.
citation: Ferreira JP, Butler J, Zannad F, Filippatos G, Schueler E, Steubl D, Zeller C, Januzzi JL, Pocock S, Packer M, Anker SD. Mineralocorticoid Receptor Antagonists and Empagliflozin in Patients With Heart Failure and Preserved Ejection Fraction. J Am Coll Cardiol. 2022 Mar 29;79(12):1129-1137. doi: 10.1016/j.jacc.2022.01.029.
citation: Ferreira JP, Anker SD, Butler J, Filippatos G, Iwata T, Salsali A, Zeller C, Pocock SJ, Zannad F, Packer M. Impact of anaemia and the effect of empagliflozin in heart failure with reduced ejection fraction: findings from EMPEROR-Reduced. Eur J Heart Fail. 2022 Apr;24(4):708-715. doi: 10.1002/ejhf.2409. Epub 2022 Jan 9.
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