Clinical trial NCT04564170: Eating Disorders and Autism Spectrum Disorders
Official title: Characterization and Relationship Between Eating Disorders and Autism Spectrum Disorders.
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Eating Disorders
Keywords: eating disorders
autism spectrum disorders
Lead sponsor: Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
Sponsor class: OTHER
First posted: 2020-09-25
Enrollment: 135
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: CASE_CONTROL
Time perspective: CROSS_SECTIONAL
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Patients with ED and HC without ED.

Brief summary: This is an observational study where patients with eating disorders (ED) are compared with healthy controls without eating disorder (HC) regarding eating disorders features and autism spectrum features. Also patients will be reassessed after 5 years.

Detailed description: The first author who suggested that eating disorders (EAD) and autism spectrum disorders (ASD) share common features was Christopher Gilberg in 1980. Currently it is known that patients with ED have social impairment, which is also a risk marker to develop ED, eating disturbances are overrepresented in ASD, ED and ASD have common behavioural features such as rigidity, perfectionism, and harm avoidance; and common cognitive profiles such as inflexibility, high attention to detail, high scores in systemizing profiles and poor results in advanced theory of mind tests. This relationship is also supported by similar neural phenotypes such as atypical structure and function in social brain regions found in both disorders.

The aim of the present study is to explore the relationship between ED and ASD traits in a sample of Spanish participants diagnosed with AN, bulimia nervosa (BN), binge-eating disorder (BED) and other eating disorders (OED). Specifically, the investigators aim to explore possible differences within the different ED and its particular transdiagnostic features in association with autistic traits.

The sample will consist of 90 patients with ED and 45 healthy controls (HC) without any current or lifetime history of mental disorder, both groups will be compared regarding ED and ASD features. Also patients will be reassessed in a 5 year follow up.

Eligibility criteria: Inclusion Criteria:

* Being Diagnosed with ED

Exclusion Criteria:

* language or intellectual impairment

Primary outcomes:
measure: Autism Spectrum Quotient
timeFrame: one year
measure: Eating Disorders Inventory
timeFrame: one year
Secondary outcomes:
measure: Bulimic Investigatory Test Edinburgh
timeFrame: one year
measure: Quality of Life Enjoyment and Satisfaction Questionnaire
timeFrame: one year
measure: Beck Depression Inventory
timeFrame: one year
measure: Scale Unawareness of Mental Disorders.
timeFrame: one year
measure: Body Shape Questionnaire
timeFrame: one year
measure: Rosenberg Self -Esteem Scale
timeFrame: one year
measure: State Trait Anxiety Inventory
timeFrame: one year
measure: Inventory of interpersonal problems personality disorder
timeFrame: one year
Other outcomes:
Locations:
city: Barcelona
country: Spain
facility: Cristina Carmona
Study officials:
References:
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