louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT02439151: New Lung Ventilation Strategies Guided by Transpulmonary Pressure in VV-ECMO for Severe ARDS
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Respiratory Distress Syndrome, Adult
Keywords: Extracorporeal Membrane Oxygenation
Lead sponsor: Beijing Chao Yang Hospital
Sponsor class: OTHER
First posted: 2015-05-08
Enrollment: 104
Sex: ALL
Minimum age (years): 18
Maximum age (years): 65
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: Extracorporeal membrane oxygenation (ECMO) has been widely used in patients with severe acute respiratory distress syndrome (ARDS). But how to choose mechanical ventilation strategy is still not clear for severe ARDS patients supported by ECMO. Our previous work found that, compared to the traditional "lung rest" strategy, transpulmonary pressure guide new lung ventilation strategy can better maintain lung volume reduction lung collapse, atelectasis occurs. The severe ARDS patients receiving ECMO therapy were randomized divided into a new ventilation strategy group and the conventional ventilation strategy group. The new ventilation strategy is transpulmonary pressure guide ventilator setting method, and the conventional ventilation strategy is Extracorporeal Life Support Organization (ELSO) guide ventilation method. Compare the difference between the two groups of patients in lung injury, and explore the lung protection mechanism of new lung ventilation strategies guided by transpulmonary pressure. Our research group considered that transpulmonary pressure guide new lung ventilation strategy can provide more effective lung protection. And it will be further used in clinical work.


Eligibility criteria: Inclusion Criteria:

* ARDS cause reversible;
* Pure oxygen is given, but PaO2/FiO2\<80;
* P(A-a)O2\>600mmHg;
* Murray score≥3.0;
* pH\<7.2;

Exclusion Criteria:

* peak inspiratory pressure\>30cmH2O;
* high FiO2\>0.8;
* ventilation\>7 days;
* contraindication to heparinization;
* non-reversible central nervous system injury
* chronic disease with a short life expectancy

Primary outcomes:
measure: Proportion weaned from VV-ECMO
timeFrame: After patients randomized grouping 60 days
Secondary outcomes:
measure: 60-day mortality
timeFrame: After patients randomized grouping 60 days
Other outcomes:
Locations:
city: Beijing
country: China
facility: Beijing Chao-Yang Hospital
state: Beijing
Study officials:
affiliation: Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China
name: Bing Sun, master
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT04776551: Percutaneous Fixation of Acute Scaphoid Fractures
Official title: Percutaneous Trans-trapezial Fixation of Acute Scaphoid Fractures by Herbert Screw
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Scaphoid Fracture
Lead sponsor: Sohag University
Sponsor class: OTHER
First posted: 2021-03-01
Enrollment: 20
Sex: ALL
Minimum age (years): 16
Maximum age (years): 60
Standard ages: CHILD
ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: TREATMENT

Brief summary: Percutaneous Trans-trapezial fixation of acute Scaphoid fractures by Herbert screw

Detailed description: Aim of the work:

To assessment outcomes of percutaneous Trans-trapezial fixation of acute scaphoid fracture.

Operative Technique:

Anesthesia: carried out under general anesthesia or brachial plexus block and under tourniquet control.

Position: supine. Approach: Percutaneous Trans-trapezial fixation of acute Scaphoid fracture. Recording any intraoperative complication that may affect the result.

Postoperative Follow Up:

Short arm circular cast including the thumb will be applied. After 3 weeks, cast will be removed and exercises will start.

Eligibility criteria: Inclusion Criteria:

* - Acute stable non displaced waist fracture (A2).
* Acute unstable oblique distal third (B1).
* Acute unstable displaced waist (B2).
* Acute un stable fracture dislocation (B4).
* Acute un stable comminuted fracture (B5).

Exclusion Criteria:

* - Acute stable fracture tubercle (A1).
* Acute unstable fracture proximal pole (B3).
* Delayed union fracture (C).
* Established non-union fracture includes fibrous (D1) and sclerotic (D2).
* Bilateral fractures because of possible interference with postoperative grip strength measurement.

Primary outcomes:
measure: Change of wrist power
timeFrame: Up to 18 months
Secondary outcomes:
Other outcomes:
Locations:
city: Sohag
country: Egypt
facility: Sohag university hospital
Study officials:
References:
Clinical trial NCT06268951: Recovery and Symptom Relief Following Percutaneous Ablation of Abdominal Wall Endometriosis
Official title: Recovery and Symptom Relief Following Percutaneous Ablation of Abdominal Wall Endometriosis
Study type: OBSERVATIONAL
Overall status: ENROLLING_BY_INVITATION
Conditions: Endometriosis
Keywords: Abdominal Wall endometriosis
Lead sponsor: Mayo Clinic
Sponsor class: OTHER
First posted: 2024-02-21
Enrollment: 50
Sex: FEMALE
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Patients diagnosed with endometriosis of the abdomen wall.

Brief summary: To determine the characteristics of recovery and symptom relief following ablation of abdominal wall endometriosis.

Detailed description: The purpose of this study is to characterize the recovery and symptom relief following cryoablation of abdominal wall endometriosis. Patients undergoing clinically indicated ablation of abdominal wall endometriosis will receive an endometriosis-specific symptom survey (Endometriosis Health Profile - 30) prior to ablation and then at 3-, 6-, 12-, and 24-months following treatment. A 2 question survey related to pain at the treatment site will also be administered prior to ablation and then at 1-, 7-, and 30-days after ablation.

Eligibility criteria: Inclusion Criteria:

* Undergoing ablation for abdominal wall endometriosis.

Exclusion Criteria:

* Decline to participate in research.

Primary outcomes:
measure: Symptom severity due to abdominal wall endometriosis following ablation.
timeFrame: Baseline and intermittently over 24 months
Secondary outcomes:
Other outcomes:
Locations:
city: Rochester
country: United States
facility: Mayo Clinic
state: Minnesota
Study officials:
affiliation: Mayo Clinic
name: Thomas Atwell, M.D.
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT03459651: Effect of Turner Syndrome on Number Sense
Official title: Investigation of the Role of Turner Syndrome on Approximate Number Sense
Study type: INTERVENTIONAL
Overall status: WITHDRAWN
Phase: NA
Conditions: Turner Syndrome
Keywords: numeracy
number sense
Lead sponsor: Stanford University
Sponsor class: OTHER
First posted: 2018-03-09
Enrollment: 0
Sex: FEMALE
Minimum age (years): 6
Maximum age (years): 40
Standard ages: CHILD
ADULT
Accepts healthy volunteers: yes
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: TREATMENT

Brief summary: This study evaluates approximate number sense (ANS) in children, adolescents, and adult women with Turner syndrome compared to age-matched healthy peers. One primary aim of this project is to assess the effectiveness of an online ANS training tool in enhancing complex mathematics ability. Participants will undergo weekly training sessions in their own home. Half of the participants will complete 2 training sessions a week for 8 weeks, and the second half will complete 1 training session for 8 weeks.


Eligibility criteria: Inclusion Criteria:

* Children, adolescents, and adult women with Turner syndrome.
* Healthy controls.
* Normal or corrected to normal vision.

Exclusion Criteria:

* Major psychiatric or developmental disorder (e.g., bipolar disorder, major depression, psychotic disorders, intellectual disability, autism spectrum disorder).
* Chemical dependency
* Currently taking the following medications: antidepressant, antipsychotic, and anti-seizures drugs.

Primary outcomes:
measure: Single and multiple-operand addition and subtraction accuracy
timeFrame: 8 weeks
measure: Single and multiple-operand addition and subtraction response time
timeFrame: 8 weeks
Secondary outcomes:
Other outcomes:
Locations:
city: Stanford
country: United States
facility: Center for Interdisciplinary Brain Sciences Research
state: California
Study officials:
References:
Clinical trial NCT02441751: Intraoperative Volume Management and QT Interval
Official title: Intraoperative Repolarisation - Etiology and Relevance for the Decision Making by Anesthesiologists in the Management of Volume Substitution and Transfusion
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Blood Loss, Surgical
Keywords: Electrocardiography
Hemorrhage
Monitoring, Intraoperative
Lead sponsor: Technische Universität Dresden
Sponsor class: OTHER
First posted: 2015-05-12
Enrollment: 200
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: patients for major surgery in urology and orthopedics

Brief summary: QT interval changes is measured during all phases of the operation. The protocol is focusing at intraoperative bleeding events and is also observing QT interval changes during anesthetic and operative procedures.

Detailed description: Prolongation of the QT interval is associated with functional torsade de points, re-entry, and sudden death (see reference). Variations of QT-interval caused by changes in the volume status of the patient during an operation remained unclear. QT interval changes will be monitored during the surgery with the focus of the influence of sudden blood loss, volume substitution by crystalloids, blood and blood products. The effect of surgical procedures on the QT-interval (e.g. clamping of kidney artery) will be observed as well as the association of intra-operative QT-interval alterations with postoperative complications.

Eligibility criteria: Inclusion Criteria:

* American Society of Anesthesiologists physical status classification 2 - 3
* patients after consent

Exclusion Criteria:

* Children,
* pregnant women,
* patients not able to consent

Primary outcomes:
measure: change in QT-time
timeFrame: during operation
Secondary outcomes:
measure: postoperative incidents/disturbance rhythm of the heart
timeFrame: 2 days
measure: survival
timeFrame: 1 year
Other outcomes:
Locations:
city: Dresden
country: Germany
facility: Dept. of Anesthesia and Intensive Care, University Hospital, Technische Universität Dresden
Study officials:
affiliation: University Hospital Dresden, TU Dresden
name: Torsten Richter, M.D.
role: STUDY_DIRECTOR
References:
citation: Straus SM, Kors JA, De Bruin ML, van der Hooft CS, Hofman A, Heeringa J, Deckers JW, Kingma JH, Sturkenboom MC, Stricker BH, Witteman JC. Prolonged QTc interval and risk of sudden cardiac death in a population of older adults. J Am Coll Cardiol. 2006 Jan 17;47(2):362-7. doi: 10.1016/j.jacc.2005.08.067.
Clinical trial NCT01695551: Brain Perfusion and Hemodynamic Stability in Patients Undergoing Radiofrequency Ablation of Ventricular Tachycardia
Official title: Assessment of Intracardiac and Surgace Electrogram Characteristics Correlated to Brain Perfusion and Hemodynamic Stability in Patients Undergoing Radiofrequency Ablation of Ventricular Tachycardia
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Ventricular Tachycardia
Keywords: Radiofrequency ablation
fast heart rhythm
ventricle
catheter ablation
ablation
Lead sponsor: University of Kansas Medical Center
Sponsor class: OTHER
First posted: 2012-09-28
Enrollment: 11
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Participants will be selected from those that visit University of Kansas Medical Center Cardiology clinics.

Brief summary: Ventricular tachycardia (VT) is a life-threatening, fast heart rhythm that starts in the lower chambers of the heart (the ventricles). This fast heartbeat is caused by abnormal electrical pathways located in the heart tissue. A standard procedure called a catheter ablation has been used for several years to help correct these abnormal pathways and, in some cases, improve or even eliminate the ventricular tachycardia.

During a VT ablation it is routine to monitor your vital signs (blood pressure, heart rate, and oxygen saturation in your blood). If you choose to participate in this study we will also monitor your cerebral oximetry, the amount of blood flow and oxygen saturation to your brain during the ablation.

By doing this study, we hope to have a better understanding of patients' blood and oxygen flow to their brain during an episode of Ventricular Tachycardia (VT).


Eligibility criteria: Inclusion Criteria:

* Able to give informed consent
* Have implantable defibrillator in-situ and are undergoing ablation procedure for ventricular tachycardia

Exclusion Criteria:

* Patients who have been hypotensive with systolic blood pressure of \< 80mm Hg prior to procedure
* Cerebral event as defined by Cerebrovascular Accident or Transient Ischemia Attack within six months prior to procedure

Primary outcomes:
measure: Identify clinical, EKG and EGM characteristics of hemodynamically unstable VT
timeFrame: Change from Baseline to 24-48 hours after surgery
Secondary outcomes:
measure: MMSE to determine cerebral function before and after VT ablation
timeFrame: 24 hours after surgery
Other outcomes:
Locations:
city: Kansas City
country: United States
facility: University of Kansas Medical center
state: Kansas
Study officials:
affiliation: University of Kansas Medical Center
name: Dhanunjaya Lakkireddy, MD, FACC
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT02119351: A Study Evaluating the Clinical Performance of the ViaValve™ Safety IV Catheter
Official title: A Post-market, Randomized Study Evaluating the Clinical Performance of the ViaValve™ Safety IV Catheter
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Peripheral Intravenous Catheter
Keywords: peripheral intravenous catheters
blood exposure
blood control
IV catheter insertion
Lead sponsor: Smiths Medical, ASD, Inc.
Sponsor class: INDUSTRY
First posted: 2014-04-21
Enrollment: 150
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: SUPPORTIVE_CARE

Brief summary: The objective of this post-market, prospective study is to evaluate the clinical acceptability, blood leakage, risk for blood exposure, need for digital compression, insertion success, and clinical utility of the ViaValve™ Safety IV Catheter compared to standard hospital PIVCs currently being used.


Eligibility criteria: Inclusion Criteria:

* A peripheral intravenous catheter will need to be inserted in order to gain access to a vein or artery to sample blood, monitor blood pressure, or administer fluids intravenous infusion as part of treatment.
* Willing and able to sign an Informed Consent (patient or legally authorized representative).

Exclusion Criteria:

* Body morphology (e.g., size) precludes the use of a peripheral intravenous catheter.
* Fluid to be infused is not appropriate for peripheral intravenous catheters.

Primary outcomes:
measure: Clinical acceptability of PIVC insertion
timeFrame: Clinicians will provide the rating immediately after performing the insertion
measure: Frequency of blood leakage
timeFrame: Clinicians will report if blood leakage occurred immediately after the catheter insertion
measure: Eliminating risk of blood exposure
timeFrame: Clinicians will report on the ability of the PIVC to eliminate blood exposure immediately after catheter insertion
Secondary outcomes:
measure: Insertion success
timeFrame: Clinicians will report if the insertion was successful immediately after performing insertion
measure: Elimination of digital compression
timeFrame: Clinicians will provide the rating immediately after performing the insertion
measure: Ease of Use
timeFrame: Clinicians will provide the rating immediately after performing the insertion
Other outcomes:
Locations:
city: Calgary
country: Canada
facility: Foothills Medical Centre
state: Alberta
Study officials:
affiliation: U of Calgary and Alberta Health Services
name: Andrew McRae, MD, PhD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT01478451: Acute Effect of Massage and Exercise on Muscle Tenderness
Official title: Danish: Integreret Motion på Arbejdspladsen (IRMA) English: Implementation of Exercise at the Workplace
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Musculoskeletal Disorders
Keywords: DOMS
Lead sponsor: National Research Centre for the Working Environment, Denmark
Sponsor class: OTHER_GOV
First posted: 2011-11-23
Enrollment: 20
Sex: ALL
Minimum age (years): 18
Maximum age (years): 67
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: CROSSOVER
Primary purpose: PREVENTION

Brief summary: Many people experience pain, tenderness and soreness of joint and muscles, both in sport and working life. Pain killers can provide acute relief of pain, but may not be a feasible solution for all people. Here the investigators examine the acute effect of massage and exercise on induced muscle tenderness (delayed onset muscular soreness).


Eligibility criteria: Inclusion Criteria:

* working age adults

Exclusion Criteria:

* blood pressure above 160/100
* disease of the cervical spine

Primary outcomes:
measure: Perceived tenderness of the trapezius muscle on a numerical rating scale of 0-10
timeFrame: change from before to after the acute intervention (average of 0, 10, 20 and 60 min after the intervention)
measure: Pressure pain threshold of the trapezius muscle
timeFrame: change from before to after the acute intervention (average of 0, 10, 20 and 60 min after the intervention)
Secondary outcomes:
Other outcomes:
Locations:
city: Copenhagen
country: Denmark
facility: National Research Centre for the Working Environment
Study officials:
affiliation: Senior Researcher
name: Lars L Andersen, PhD
role: PRINCIPAL_INVESTIGATOR
References:
citation: Andersen LL, Jay K, Andersen CH, Jakobsen MD, Sundstrup E, Topp R, Behm DG. Acute effects of massage or active exercise in relieving muscle soreness: randomized controlled trial. J Strength Cond Res. 2013 Dec;27(12):3352-9. doi: 10.1519/JSC.0b013e3182908610.
Clinical trial NCT05674851: Modeling Organ Motion During Abdominal Imaging in Healthy Volunteers
Official title: Study and Modeling of Organ Motion During Abdominal Imaging
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Healthy Volunteers
Keywords: Magnetic Resonance Imaging (MRI)
Abdominal Cancer
Radiation Therapy Planning
Lead sponsor: Duke University
Sponsor class: OTHER
First posted: 2023-01-09
Enrollment: 5
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: OTHER

Brief summary: In this study, we plan to systematically analyze the motion of organs and tissues in the abdomen, to understand the physical mechanisms of three-dimensional (3D) motion and interactions of abdominal organs and tissues. This work will allow us to learn how to mathematically model and predict abdominal organ motion.

Detailed description: Specifically, we plan to conduct this study in 3 steps, in an order of increasing complexity, starting with the (intra-fractional) respiratory only motion, then adding intra-fractional GI motility motion, and finally the inter-fractional anatomical variations (adding food intakes and fecal excretion). The research methods described will allow the study team to develop the ability to estimate the motion of both tumor target and critical organs given the patient's MRI, CBCT or x-ray fluoroscopy images on the day of radiation treatment.

Eligibility criteria: Inclusion Criteria:

* No contraindications for MRI (e.g., unsafe MRI implanted devices, shrapnel, history of metal fragments in eyes, neurostimulators, body habitus, claustrophobia).
* May have pre-existing medical conditions provided they are capable of completing the exam and their condition is not expected to affect the physical tissue properties of the organs that will be imaged.
* Women of child-bearing potential must verbally confirm lack of pregnancy prior to signing consent

Exclusion Criteria:

* None

Primary outcomes:
measure: abdominal respiratory motion as measured by MRI
timeFrame: baseline
measure: gastrointestinal motility motion as measured by MRI
timeFrame: baseline
measure: inter-fractional motion as measured by MRI
timeFrame: baseline, up to 6 months
Secondary outcomes:
Other outcomes:
Locations:
city: Durham
country: United States
facility: Duke University Medical Center
state: North Carolina
Study officials:
affiliation: Duke University Health System (DUHS)
name: John Ginn, PhD
role: PRINCIPAL_INVESTIGATOR
affiliation: Duke University Health System (DUHS)
name: Deshan Yang, PhD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT06811051: Effect of Clove Oil and Menthol Lozenges on Post-extubation Sore Throat
Official title: Effects of Clove Oil and Menthol-containing Lozenges in Preventing Post-extubation Sore Throat in Patients Undergoing Surgical Intervention
Study type: INTERVENTIONAL
Overall status: ENROLLING_BY_INVITATION
Phase: EARLY_PHASE1
Conditions: Sore Throat
Keywords: sore throat
lozenge
postoperative
Lead sponsor: Atlas University
Sponsor class: OTHER
Collaborators: name: Bakirkoy Dr. Sadi Konuk Research and Training Hospital
First posted: 2025-02-06
Enrollment: 150
Sex: ALL
Minimum age (years): 18
Maximum age (years): 65
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: CROSSOVER
Primary purpose: PREVENTION

Brief summary: In patients undergoing surgical intervention, endotracheal intubation, which is a part of the anesthesia procedure, can cause postoperative sore throat in patients. This situation causes difficulty in swallowing, inadequate nutrition and fluid intake, and prolongs the recovery process. In addition, sore throat is defined as a source of physical stress, which can lead to an increase in the incidence of postoperative morbidity and a decrease in patient satisfaction. This study aimed to investigate the effect of menthol and clove oil lozenges on sore throat after surgery. Our aim was to provide evidence on the effectiveness of simple, low-cost menthol and clove oil lozenges in reducing sore throat after extubation, thus helping the patient recover.

Detailed description: This study aimed to investigate the effect of menthol and clove oil lozenges on sore throat in patients after surgery.

Eligibility criteria: Inclusion Criteria:

* Being between the ages of 18-65. Having had abdominal surgery. Being extubated within the first 8 hours after surgery. ASA class I-III. Mallampati class I-II. Glasgow Coma Scale (GCS) score 15

Exclusion Criteria:

* History of allergies.

  * Severe nausea and vomiting.
  * Being extubated after the first 8 hours after surgery.
  * Communication disorders
  * Mallampati class III-IV.
  * Glasgow Coma Scale (GCS) score \<15

Primary outcomes:
measure: VAS pain score
timeFrame: Pain was assessed at 4 time points, immediately before the first application (baseline) and 30 minutes after application of each of the three lozenges (T1, T2, T3).
measure: sore throat
timeFrame: 60 minutes after extubation
Secondary outcomes:
measure: Sore throat
timeFrame: 90 minutes after extubation
Other outcomes:
Locations:
city: İstanbul
country: Turkey
facility: İstanbul Atlas University
state: Kağıthane
city: Istanbul
country: Turkey
facility: Bakirkoy Dr. Sadi Konuk Training and Research Hospital
Study officials:
References: