Clinical trial NCT02190409: An Invivo Study to Compare the Stability of Dental Implants With or Without Platelet Rich Fibrin Application
Official title: The Effect Of Platelet Rich Fibrin on Implant Stability
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Dental Implant
Keywords: Dental Implant,
Lead sponsor: Necmettin Erbakan University
Sponsor class: OTHER
Collaborators: name: Baskent University
First posted: 2014-07-15
Enrollment: 20
Sex: ALL
Minimum age (years): 18
Maximum age (years): 55
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: HEALTH_SERVICES_RESEARCH

Brief summary: The purpose of this study was to evaluate the effects of (Platelet Rich Fibrin) PRF application on implant osseointegration in the early phase of healing.

Detailed description: Objectives:Achieving accelerated implant osseointegration could provide immediate or early loading of implants. Platelet-rich fibrin (PRF) is widely used to accelerate soft and hard tissue healing. Activated platelets in PRF release growth factors resulting in cellular proliferation, collagen synthesis and osteoid production. The aim of this study was to compare the stability of dental implants inserted with one-stage surgical protocol with or without PRF application.

Design: Non-randomized, Active Controlled Trial. Material and Methods: Twenty healthy patients (n=10 test group, n= control group) with adequate alveolar bone, having 2 or more adjacent missing teeth, extracted at least 6 months ago were included in this study. Minimum two tapered implants (Ankylosis, DentsplyFriadent) were placed to each patient. After surgical preparation of implant sockets, PRF that was prepared preoperatively was placed randomly to one of the sockets (PRF+). Acellular plasma portion of PRF was used to wet the implant placed into the PRF-coated socket. Resonance frequency measurements were made by Osstell ISQ after placement of implants, at 1 week and one month postoperatively.

Key Words: Dental implant stability, Platelet Rich Fibrin, Resonance frequency analysis

Eligibility criteria: Inclusion Criteria:

* The absence of any lesions in the oral cavity, and sufficient residual bone volume to receive two or more adjacent implants of ≥3.5 mm in diameter and 11.0 mm in length, and extracted at least 6 months ago.

Exclusion Criteria:

* Insufficient bone volume
* Parafunctional habits
* Smoking more than 10 cigarettes per day
* Excessive consumption of alcohol
* Localized radiotherapy of the oral cavity
* Antitumor chemotherapy
* Liver, blood, and kidney diseases
* Immunosuppression
* Current corticosteroid or bisphosphonate use
* Pregnancy
* Mucocutaneous diseases involving oral cavity
* Poor oral hygiene

Primary outcomes:
measure: Implant Stabilitty Quotient (ISQ) evaluation: analysis of the resonance frequency values 4 week period.
timeFrame: Resonance frequency measurements were made by Osstell ISQ after placement of implants, at 1 week and one month postoperatively.
Secondary outcomes:
measure: Evaluation of osseointegration in different types of bone
timeFrame: Resonance frequency measurements in different bone types were made by Osstell ISQ after placement of implants, at 1 week and one month postoperatively.
Other outcomes:
Locations:
city: Ankara
country: Turkey
facility: NECMETTIN ERBAKAN University Faculty of Dentistry, Department of Periodontology,
Study officials:
affiliation: NECMETTİN ERBAKAN UNIVERSITY
name: ELİF ÖNCÜ, 1
role: PRINCIPAL_INVESTIGATOR
References: