Clinical trial NCT01900847: Ketamine and Morphine Versus Morphine Alone for the Treatment of Acute Pain in the Emergency Department
Official title: Ketamine and Morphine Versus Morphine Alone for the Treatment of Acute Pain in the Emergency Department
Study type: INTERVENTIONAL
Overall status: TERMINATED
Phase: NA
Conditions: Acute Pain
Keywords: Ketamine
Acute Pain
Lead sponsor: University of Arizona
Sponsor class: OTHER
Collaborators: name: American College of Emergency Physicians
First posted: 2013-07-17
Enrollment: 17
Sex: ALL
Minimum age (years): 18
Maximum age (years): 100
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: Our goal is to study whether giving people low dose ketamine along with morphine when they come to the Emergency Department will help their pain more than giving morphine by itself. There have been many studies showing that low dose ketamine is safe and effective for pain control. Ketamine is frequently used for pain control in ambulances and helicopters transporting injured patients to the hospital and has also been used for pain control in people who have just had surgery. The investigators would like to see if low dose ketamine would be safe and effective for patients with pain in the Emergency Department.

Patients are eligible for the study if they come to the Emergency Department and their treating physician decides to treat them with morphine (with certain exceptions such as pregnant patients and patients with eye injuries). They will be given information about participating in the study and if they agree, they will be given the study drug. The study drug will be either ketamine or salt water (saline). If patients continue to be in pain they will continue to receive doses of morphine just as they would if they were not in the study. If the treating physician feels that morphine alone is not enough, they will be free to choose another pain medication as they would normally.


Eligibility criteria: Inclusion Criteria:

* Presenting to Emergency Department in acute pain
* age 18 and over
* determined to require morphine for pain control by treating physician

Exclusion Criteria:

* Patients presenting with headache or head injury
* Patient with eye injury or eye pain
* Nontraumatic chest Pain
* Pregnant patients or women of childbearing potential
* Patients allergic to morphine or ketamine
* Patients with known history of narcotic/alcohol abuse or presenting for narcotic medication refill
* Patients with hypertension: diastolic blood pressure \> 100 OR systolic blood pressure \> 180
* Patient whose pain is so severe that they are unable to give informed consent
* Patients who have had bad experiences to prior hallucinations from any origin

Primary outcomes:
measure: Numeric Pain Score
timeFrame: Baseline (zero minutes), 30 minutes and 1 hour after receiving study drug
Secondary outcomes:
measure: Total Amount of Morphine and Other Pain Medications Administered
timeFrame: Data collected from the duration of the patient's Emergency Department stay (expected average 5 hours)
measure: Number of Participants With Adverse Events
timeFrame: Data collected from the duration of the patient's Emergency Department stay (expected average 5 hours)
Other outcomes:
Locations:
city: Tucson
country: United States
facility: University of Arizona Health Network University Campus 1501 North Campbell Ave
state: Arizona
Study officials:
References:
citation: Berkman, M. R., Larsen, J., Smith, J., Caldwell, J., Waterbrook, A., Stolz, U., & Denninghoff, K. (2014). 369 Ketamine and Morphine versus Morphine Alone for Treatment of Acute Pain in the Emergency Department. Annals of Emergency Medicine, 64(4), S131-S132.