Clinical trial NCT02825732: MEMORA-Caregiver : Risk Factors of Caregiver Burden Among Patients With Neurocognitive Disorders or Subjective Cognitive Complaint
Official title: MEMORA-Caregiver : Risk Factors of Caregiver Burden Among Patients With Neurocognitive Disorders or Subjective Cognitive Complaint
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Neurocognitive Disorders
Keywords: Alzheimer's disease or related disorder
Comorbidity
Charlson comorbidity index
Caregiver burden
Cohort
Dementia
Behavioral disorders
Functional dependency
Lead sponsor: Hospices Civils de Lyon
Sponsor class: OTHER
First posted: 2016-07-07
Enrollment: 1300
Sex: ALL
Minimum age (years): 50
Maximum age (years): 100
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: RETROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: The study population includes a sample of consecutive dyads of patient-caregiver consulting a neurologist or a geriatrician for a cognitive complaint between November 2011 and December 2014 at the Memory Clinic of the Hospital Charpennes, Villeurbanne, France.

Brief summary: The investigators will investigate which patients' characteristics are associated with caregivers burden and its evolution for outpatients visiting a memory clinic, in particular how functional autonomy, behavioral and psychological symptoms as well as patients comorbidities can influence caregiver burden.

The study will be conducted among outpatients with progressive cognitive complaint followed in a Memory Clinic and their primary caregiver. The investigators hypothesis that caregivers experience a higher burden due to disease symptoms such as impairment of functional autonomy, behavioral and cognitive impairment, whatever the aetiology of the cognitive decline.


Eligibility criteria: Inclusion Criteria:

* patients with a cognitive complaint, either expressed by the patient or one of their relatives,
* patients at any stage of disease (cognitive complaint, mild cognitive impairment (MCI) or dementia),
* patients living in the community,
* patients having an informal caregiver who will complete the questionnaire to assess the caregiver burden.

Exclusion Criteria:

-

Primary outcomes:
measure: Evolution of caregiver burden
timeFrame: Two measured of the caregiver burden at baseline and at follow-up during current care, at 6 months to 12 months of follow-up.
Secondary outcomes:
measure: Caregiver burden
timeFrame: The caregiver burden will be measured at baseline (Day 0)
Other outcomes:
Locations:
city: Villeurbanne
country: France
facility: Clinical and Research Memory Centre of Lyon (CMRR); Geriatrics Unit, Charpennes Hospital, University Hospital of Lyon, Villeurbanne, France - Clinical Research Centre (CRC) - VCF (Aging - Brain - Frailty), Charpennes Hospital, University Hospital of Lyon
Study officials:
affiliation: Clinical and Research Memory Centre of Lyon (CMRR); Geriatrics Unit, Charpennes Hospital, University Hospital of Lyon, Villeurbanne, France - Clinical Research Centre (CRC) - VCF (Aging - Brain - Frailty), Charpennes Hospital, University Hospital of Lyon
name: Pierre Krolak-Salmon, Pr
role: PRINCIPAL_INVESTIGATOR
References:
citation: Dauphinot V, Ravier A, Novais T, Delphin-Combe F, Mouchoux C, Krolak-Salmon P. Risk Factors of Caregiver Burden Evolution, for Patients With Subjective Cognitive Decline or Neurocognitive Disorders: A Longitudinal Analysis. J Am Med Dir Assoc. 2016 Nov 1;17(11):1037-1043. doi: 10.1016/j.jamda.2016.07.003. Epub 2016 Aug 26.