Clinical trial NCT04444947: Influencing Factors in Patients With Colorectal and Gastric Polyps a Retrospective Study
Official title: Influencing Factors in Patients With Colorectal and Gastric a Retrospective Study
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Polyp, Colonic
Lead sponsor: The First Affiliated Hospital with Nanjing Medical University
Sponsor class: OTHER
First posted: 2020-06-24
Enrollment: 64889
Sex: ALL
Minimum age (years): 18
Maximum age (years): 85
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: CASE_CONTROL
Time perspective: OTHER
Sampling method: NON_PROBABILITY_SAMPLE
Study population: A total of 43,104, patients (n=21939) with polyps and patients without polyps (n=21165) is included in this study.

Brief summary: The identification of risk factors of colorectal/gastric polyp is more helpful for preventing colorectal cancer. And modifiable factors (such as high-fat diet, abnormal blood lipid, smoking, lack of exercise, obesity), and unmodifiable factors (including age, gender, race, familial adenomas, genetic)) can affect the risk of polyps. Thus early studying risk factors are the key to improving prognosis. what's more, early detection and timely treatment have important clinical significance for preventing and reducing the occurrence of gastrointestinal cancer.

Detailed description: Colorectal cancer (CRC) is the third most common cancer in the world. what's more, CRC is therefore an important public health concern in China due to its rising incidence and prevalence, in addition to the burden of disease. There is robust evidence indicating that early detection by screening and removal of cancer precursor lesions offers an effective method of reducing colorectal cancer morbidity and mortality. Studies have shown that colorectal polyps are considered to be related to colorectal cancer, especially adenoma .The primary aim of this study was to identify high risk features of multiple polyps based on size, location and histological type. Patient age and gender were also characterized on the basis of a contingency analysis of a large series of Chinese patients with colorectal polyps. These data provide important information on risk factors associated with multiple polyps, which will serve as evidence for an individualized approach to colonoscopy screening guidelines in China.

Similarly, recent years, with the widespread use of gastroscopy, people's health awareness and lifestyle changes, more and more people have performed gastroscopy, so a large number of patients with gastric polyps can be found in the clinic. Gastric polyps are raised lesions that originate in the mucosal layer or submucosa and protrude into the stomach cavity. According to their pathological characteristics, they can be divided into two categories: mucosal layer and non-mucosal layer.Gastric polyps originating from mucosal layers, represented by natural, fundus glandular and adenomatous polyps, are the most common in clinical practice, while non-mucosal polyps including gastric stromal tumors and inflammatory fibrous polyps are more common in clinical practice. Although the incidence of gastric polyps is far less than that of intestinal polyps, some pathological types, especially adenomatous polyps, have obvious malignant potential and are recognized as precancerous lesions .

Therefore, we retrospectively analyzed the records of patients with gastrointestinal polyps in our hospital in the past years, and provided epidemiological data to study the factors in polyps.

Eligibility criteria: Inclusion Criteria:

* patients who underwent colonoscopies

Exclusion Criteria:

* (1) Patients with Crohn's disease, inflammatory bowel disease, and colorectal cancer; (2) Patients with ulcerative bowel disease, and intestinal tuberculosis; (3) Patients with history of familial polyposis; (4) All patients without complete endoscopic reports and complete demographics records.

Primary outcomes:
measure: Influencing factors in patients with colorectal polyps: a retrospective study
timeFrame: JUNE 30,2020
Secondary outcomes:
Other outcomes:
Locations:
city: Nanjing
country: China
facility: Jiangsu Provincial People's Hospital
state: Jiangsu
Study officials:
affiliation: the Human Ethics Committee of Jiangsu Provincial People's Hospital
name: yue WANG, master
role: PRINCIPAL_INVESTIGATOR
References:
citation: Han X, Qian W, Liu Y, Zheng T, Su XJ, Zhang PP, Chen Y, Hu LH, Li ZS. Effects of age, sex and pathological type on the risk of multiple polyps: A Chinese teaching hospital study. J Dig Dis. 2020 Sep;21(9):505-511. doi: 10.1111/1751-2980.12863.
citation: Song M, Emilsson L, Bozorg SR, Nguyen LH, Joshi AD, Staller K, Nayor J, Chan AT, Ludvigsson JF. Risk of colorectal cancer incidence and mortality after polypectomy: a Swedish record-linkage study. Lancet Gastroenterol Hepatol. 2020 Jun;5(6):537-547. doi: 10.1016/S2468-1253(20)30009-1. Epub 2020 Mar 17.
citation: Mariotto AB, Yabroff KR, Shao Y, Feuer EJ, Brown ML. Projections of the cost of cancer care in the United States: 2010-2020. J Natl Cancer Inst. 2011 Jan 19;103(2):117-28. doi: 10.1093/jnci/djq495. Epub 2011 Jan 12.
citation: Oines M, Helsingen LM, Bretthauer M, Emilsson L. Epidemiology and risk factors of colorectal polyps. Best Pract Res Clin Gastroenterol. 2017 Aug;31(4):419-424. doi: 10.1016/j.bpg.2017.06.004. Epub 2017 Jun 28.