Clinical trial NCT04907487: Évaluation de l'Impact du Compressed Sensing Sur le Signal QSM
Official title: Évaluation de l'Impact du Compressed Sensing Sur le Signal QSM
Study type: OBSERVATIONAL
Overall status: RECRUITING
Conditions: MRI
Lead sponsor: Fondation Ophtalmologique Adolphe de Rothschild
Sponsor class: NETWORK
First posted: 2021-05-28
Enrollment: 60
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: CASE_CONTROL
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Two groups of patients will be included as part of this research protocol:

* Group I: Patients with MS
* Group II: Patients with an indication to undergo a brain MRI and at low risk of inflammatory CNS pathology, age and gender matched with group I.

Brief summary: Patients who have agreed to participate in the study will complete the MRI protocol as part of routine care, to which a maximum of four additional 25-minute sequences will be added.

MRI of routine care includes at least the following sequences:

* 3D T1 TFE (2 minutes)
* T2 TSE (2 minutes)
* 3D FLAIR (3 minutes)

The sequences added by the research lasting 25 minutes are:

* SWI QSM 1.0iso 8 echoes (10 minutes)
* SWI QSM 1.0iso 8 echoes CS 6 (7 minutes)
* SWI QSM 1.0iso 8 echoes CS 9 (5 minutes)
* SWI QSM 1.0iso 8 echoes CS 12 (3 minutes)

Detailed description: Patients who have agreed to participate in the study will complete the MRI protocol as part of routine care, to which a maximum of four additional 25-minute sequences will be added.

MRI of routine care includes at least the following sequences:

* 3D T1 TFE (2 minutes)
* T2 TSE (2 minutes)
* 3D FLAIR (3 minutes)

The sequences added by the research lasting 25 minutes are:

* SWI QSM 1.0iso 8 echoes (10 minutes)
* SWI QSM 1.0iso 8 echoes CS 6 (7 minutes)
* SWI QSM 1.0iso 8 echoes CS 9 (5 minutes)
* SWI QSM 1.0iso 8 echoes CS 12 (3 minutes)

Eligibility criteria: Inclusion Criteria:

For patients with MS:

* Patient over 18 years old
* Presenting MS defined according to McDonald's revised criteria for spatial and temporal clinical or radiological dissemination \[16\],
* Should benefit as part of the care of an MRI examination with or without injection of gadolinium
* Express consent to participate in the study
* Affiliate or beneficiary of a social security scheme

For patients with an indication to undergo a brain MRI and at low risk of inflammatory CNS disease:

* Patient over 18 years old
* Should benefit as part of the care of an MRI examination with or without injection of gadolinium
* Express consent to participate in the study
* Affiliate or beneficiary of a social security scheme

Exclusion Criteria:

* For patients with MS:
* Patient benefiting from a legal protection measure
* Pregnant or breastfeeding woman

For patients with an indication to undergo a brain MRI and at low risk of inflammatory CNS disease:

* Patient benefiting from a legal protection measure
* Pregnant or breastfeeding woman
* Patient with inflammatory and / or demyelinating pathology of the CNS

Secondary exclusion criteria :

* Motion artefact not allowing interpretation of images
* Patient who did not perform one of the following sequences: 3D T1 TFE, 3D FLAIR (for MS patients), SWI QSM 1.0iso 8 echoes.

Secondarily excluded patients will be replaced.

Primary outcomes:
measure: concordance of QSM signal with and without compressed-sensing in white matter
timeFrame: 1 DAY
Secondary outcomes:
Other outcomes:
Locations:
city: Paris
country: France
facility: Hhopital fondation adolphe de rothschild
Study officials:
References: