Clinical trial NCT03675906: The Relationship Between Hypoalbuminemia and Development of Acute Kidney Failure (AKI) According to KDIGO Criteria
Official title: The Relationship Between Preoperative and Postoperative Hypoalbuminemia and Development of Acute Kidney Failure (AKI) According to KDIGO Criteria in Advanced Age Hip Kidney Surgery
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Hypoalbuminemia
Acute Kidney Failure
Keywords: hypoalbuminemia
Acute Kidney Failure
older age
hip fracture
Lead sponsor: Erzincan University
Sponsor class: OTHER
First posted: 2018-09-18
Enrollment: 160
Sex: ALL
Minimum age (years): 65
Standard ages: OLDER_ADULT
Accepts healthy volunteers: no
Observational model: CASE_CROSSOVER
Time perspective: RETROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: ASA I - IV physical status and under spinal anesthesia or peripheric nerve block, 160 patients over 65 years of age undergoing femoral fracture surgery between 01.01.2018 - 01.07.2018

Brief summary: This study was designed to determine the association between preoperative and postoperative hypoalbuminemia and AKI in older age hip fracture surgeons, to determine which period of hypoalbuminemia contributes more to AKI development, the incidence of AKI according to anesthesia type, the presence of other factors affecting AKI development, the duration of hospitalization and cost- to be investigated.


Eligibility criteria: Inclusion Criteria:

* patients with femur fracture surgery
* 65 years and over
* Patients with ASA I - IV physical condition
* patients with spinal anesthesia or peripheral nerve block

Exclusion Criteria:

* Patients undergoing emergency surgery
* patients with preoperative serum creatinine (sCr) level\> 1.5 mg / dl
* patients with low serum albumin levels in both preoperative and postoperative periods
* patients receiving preoperative ventilator care
* patients with spinal anesthesia or peripheral nerve block contraindications (coagulopathies, local infection at the puncture site, spot infection) or nonsteroidal antiinflammatory drug (NSAID)

Primary outcomes:
measure: hypoalbuminemia and AKI - incidence of AKI
timeFrame: 3 months
Secondary outcomes:
measure: anesthesia type - incidence of AKI
timeFrame: 3 months
Other outcomes:
Locations:
city: Erzincan
country: Turkey
facility: Erzincan University
Study officials:
References:
citation: Section 2: AKI Definition. Kidney Int Suppl (2011). 2012 Mar;2(1):19-36. doi: 10.1038/kisup.2011.32. No abstract available.
citation: Kim HJ, Koh WU, Kim SG, Park HS, Song JG, Ro YJ, Yang HS. Early postoperative albumin level following total knee arthroplasty is associated with acute kidney injury: A retrospective analysis of 1309 consecutive patients based on kidney disease improving global outcomes criteria. Medicine (Baltimore). 2016 Aug;95(31):e4489. doi: 10.1097/MD.0000000000004489.
citation: Kim K, Bang JY, Kim SO, Kim S, Kim JU, Song JG. Association of preoperative hypoalbuminemia with postoperative acute kidney injury in patients undergoing brain tumor surgery: a retrospective study. J Neurosurg. 2018 Apr;128(4):1115-1122. doi: 10.3171/2016.11.JNS162237. Epub 2017 May 5.
citation: Shin KH, Han SB. Early postoperative hypoalbuminemia is a risk factor for postoperative acute kidney injury following hip fracture surgery. Injury. 2018 Aug;49(8):1572-1576. doi: 10.1016/j.injury.2018.05.001. Epub 2018 May 2.