louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT04427553: Percutaneous Peripheral Nerve Stimulation and Performance
Official title: Effects of Percutaneous Peripheral Nerve Stimulation on Physical Performance in Soccer Players
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Sports Physical Therapy
Keywords: Percutaneous Peripheral Nerve Stimulation
Performance
Soccer
Lead sponsor: Universidad Rey Juan Carlos
Sponsor class: OTHER
First posted: 2020-06-11
Enrollment: 20
Sex: MALE
Minimum age (years): 18
Maximum age (years): 60
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: Percutaneous Peripheral Nerve Stimulation is a relative new intervention applied by physical therapists. Although it has been hypothesized that this technique could improve pain and function, no studies have investigated changes in physical performance in soccer players. This study will evaluate changes in physical performance after the application of Percutaneous Peripheral Nerve Stimulation in a sample of healthy soccer players.


Eligibility criteria: Inclusion Criteria:

* Semiprofessional soccer player
* No symptoms or injury in the lower extremity previous 6 months
* Training frequency of at least 3 days a week plus soccer game

Exclusion Criteria:

* fear to needles
* presence of pain or any musculoskeletal disease
* previous surgery in the lower extremity
* underlying medical conditions, e.g., diabetes, hypertension

Primary outcomes:
measure: Changes in Contra-Movement Jump between baseline and follow-up periods
timeFrame: Baseline and immediately after each session and 1 month after the last treatment session
Secondary outcomes:
measure: Changes in Squat Performance Speed between baseline and follow-up periods
timeFrame: Baseline and immediately after each session and 1 month after the last treatment session
Other outcomes:
Locations:
city: Alcorcón
country: Spain
facility: César Fernández-de-las-Peñas
state: Madrid
city: Alcorcon
country: Spain
facility: César Fernández-de-las-Peñas
state: Rest Of The World
Study officials:
References:
Clinical trial NCT01044953: Injury Incidence in Professional Soccer
Official title: Repercussions of a Shortened Winter Break on Injury Incidence Within the German Professional Soccer Leagues
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Injury
Keywords: injury incidence
male professional soccer
Change of injury incidence in professional soccer
Lead sponsor: Universität des Saarlandes
Sponsor class: OTHER
Collaborators: name: Deutsche Fußball-Liga GmbH (German Soccer League Ltd.)
First posted: 2010-01-08
Enrollment: 240
Sex: MALE
Minimum age (years): 16
Maximum age (years): 40
Standard ages: CHILD
ADULT
Accepts healthy volunteers: yes
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: German professional male soccer players

Brief summary: The winter break within the German Professional Football Leagues will be shortened as for the season 2009/2010 from 6.5 to 3.5 weeks. That might have repercussions on injury incidence in either way, positive or negative. On the one hand, recovery time during the winter will be shorter, which might lead to an increased risk of injury. On the other hand, it will allow a better spread of games in the second round, thus reducing the amount of the so-called "English weeks", which in turn could reduce the number of injuries. This study compares injury incidence between the season 2008/2009 (long winter break) and the season 2009/2010(short winter break) via questionnaires in accordance with UEFA/FIFA injury evaluation criteria.


Eligibility criteria: Inclusion Criteria:

* German professional male soccer players

Exclusion Criteria:

* Loss of professional status as a soccer player

Primary outcomes:
measure: injury incidence
timeFrame: 2 seasons
Secondary outcomes:
measure: types of injury
timeFrame: 2 seasons
Other outcomes:
Locations:
Study officials:
affiliation: Saarland University, Institute for Sports and Preventive Medicine
name: Karen aus der Fünten, MD, MChiro
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT02240953: Anticoagulation Regiments in Patients With Prosthetic Heart Valve Thrombosis
Official title: Comparison of Different Anticoagulation Regiments in Patients With Prosthetic Heart Valve Non-ObstructiveThrombosis
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Thrombosis
Keywords: Anticoagulation
Prosthetic Heart Valves
Acetylsalicylic acid
Warfarin
Thrombosis
Lead sponsor: Kartal Kosuyolu Yuksek Ihtisas Education and Research Hospital
Sponsor class: OTHER_GOV
First posted: 2014-09-16
Enrollment: 180
Sex: ALL
Minimum age (years): 18
Maximum age (years): 80
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: Prosthetic valve thrombosis is a serious complication with high mortality and morbidity. However, the best anticoagulant treatment strategies for patients with prosthetic heart valve thrombosis have not been fully known. In this study the investigators wanted to identify the most effective and safe regimen among different anticoagulant regimens.

Detailed description: Three different anticoagulant treatment regimens for patients with prosthetic heart valve non-obstructive thrombosis have been described. Patients are included in each group randomly. In the first arm only warfarin is given to the patients with a target INR level of 2.5-4. In the second arm 100 mg acetylsalicylic acid and a proton pump inhibitor are added to treatment in combination with warfarin. In the third arm 300 mg acetylsalicylic acid and a proton pump inhibitor are added to treatment in ombination with warfarin. Also there is an observational follow-up group of patients who do not have prosthetic heart valve thrombosis. These patients also are followed under only warfarin therapy with INR level of 2.5-4 . All patients are followed by serial transesophageal echocardiography performed every 6 months. Follow-up period is at least 6 months (range 6-60 months). Informed consent is taken from all patients.

Eligibility criteria: Inclusion Criteria:

* Patients with prosthetic heart valve thrombosis

Exclusion Criteria:

Primary outcomes:
measure: Decreased thrombus size
timeFrame: 6 months
measure: Same thrombus size
timeFrame: 6 months
measure: Increased thrombus size
timeFrame: 6 months
measure: Complications
timeFrame: 6 months
Secondary outcomes:
Other outcomes:
Locations:
city: İstanbul
country: Turkey
facility: Kosuyolu Kartal Heart Training and Research Hospital
Study officials:
References:
Clinical trial NCT04933253: Mediastinal Temperature and Post-operative Bleeding
Official title: Mediastinal Temperature and Post-operative Bleeding
Study type: INTERVENTIONAL
Overall status: WITHDRAWN
Phase: NA
Conditions: Blood Loss, Surgical
Lead sponsor: Virginia Commonwealth University
Sponsor class: OTHER
First posted: 2021-06-21
Enrollment: 0
Sex: ALL
Minimum age (years): 18
Maximum age (years): 80
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: PREVENTION

Brief summary: This study will investigate how chest temperature relates to blood loss and blood clotting. Researchers will use infra-red thermometers to measure the temperature of the chest at the end of surgery see if this relates to the amount of blood collected from the surgical drains. In addition, researchers will test if warm irrigation of the chest increases the temperature of the chest and if this impacts blood loss.

Detailed description: Low body temperature during surgery, defined as a temperature below 34 °C, occurs commonly in patients undergoing cardiac surgery due to the bypass machine and an open chest. Low body temperature has been associated with blood loss, but the relevant published data are inconclusive. Nevertheless, evidence suggests that blood loss during and after surgery are higher in low body temperature patients than in the normal body temperature patients. In addition, low body temperature can impair blood clotting. The clinical significance of this is high as it is well established that blood transfusion increases mortality after surgery.

Eligibility criteria: Inclusion Criteria:

* Patients undergoing open cardiac surgery at VCU
* Age18 to 80 years
* American Society of Anesthesiologists Physical Status 1-3

Exclusion Criteria:

* history of excessive bleeding
* partial thromboplastin time \> 35 s
* prothrombin time \> 35 s
* fibrinogen \< 200 mg/dL
* platelet count \< 100,000/L
* history of infection and fever within 4 weeks before surgery
* use of steroid or immunosuppressant within 4 weeks before surgery

Primary outcomes:
measure: Chest temperature
timeFrame: At the end of surgery, up to 5 hours
measure: Amount of blood loss
timeFrame: 24 hours after the end of surgery
Secondary outcomes:
Other outcomes:
Locations:
city: Richmond
country: United States
facility: Virginia Commonwealth University
state: Virginia
Study officials:
affiliation: Virginia Commonwealth University
name: Arturo Cardounel, M.D.
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT00869453: Gut Hormone Secretion and Macronutrients
Official title: Gut Hormone Secretion Pattern in Response to Different Macronutrients in Healthy Volunteers
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Healthy Volunteers
Keywords: Gut hormone
hyperglycaemic clamp
glucose turnver
Lead sponsor: University of Lausanne
Sponsor class: OTHER
Collaborators: name: Centre Hospitalier Universitaire Vaudois
First posted: 2009-03-26
Enrollment: 8
Sex: MALE
Minimum age (years): 18
Maximum age (years): 35
Standard ages: ADULT
Accepts healthy volunteers: yes
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Healthy male volunteers

Brief summary: The role of gut hormone (GLP-1, GIP, PYY...) in glucose homeostasis has been widely demonstrated. Furthermore modifications in their pattern of secretion seem to be involved in the improvement of glucose control in obese patients after bariatric surgery.

The purpose of this study is to assess the respective role of carbohydrate, fat and protein from a complete meal in gut hormones secretion.

Detailed description: The study is designed to asses the role of each individual macronutrient of a compete meal in gut hormones secretion in healthy volunteers.

8 healthy young male subjects will be studied on 5 different occasions. To asses the role of each macronutient the subjects will recieve one of the following test meal: a complete sandwich, the proteic part of this complete meal, the glucidic part and the lipidic part. The fifth test will be a fasting test.

To assess the entero-insular axis, a 5.5 hours hyperglycaemic clamp will be performed.

Eligibility criteria: Inclusion Criteria:

* Male
* 18-35 years old
* 19 kg/m2 ≤ BMI ≤ 25 kg/m2
* Healthy
* Low to moderate physical activity
* Non smokers

Exclusion Criteria:

* Family history of diabetes mellitus
* Any medication
* Participation to blood spending or other clinical study in the 3 months before the beginning of this study
* Consumption of drugs
* Consumption of more than 50g of alcool in a week
* Vegetarian or particular diet
* Anamnèse d'intolérance alimentaire
* Family history of food intolerance

Primary outcomes:
measure: Gut hormone secretion
timeFrame: within 4 hours following a test meal
Secondary outcomes:
measure: Entero-insular axis measurement
timeFrame: within 4 hours following a test meal
measure: Glucose turnover
timeFrame: 6 hours
measure: Insulin sensitivity
timeFrame: 6 hours
measure: Substrate oxidation
timeFrame: 6 hours
Other outcomes:
Locations:
city: Lausanne
country: Switzerland
facility: Cardiomet Clinical research Center, CHUV
state: VD
city: Lausanne
country: Switzerland
facility: University of Lausanne
Study officials:
affiliation: Centre Hospitalier Universitaire Vaudois
name: Luc Tappy, MD
role: PRINCIPAL_INVESTIGATOR
References:
citation: Carrel G, Egli L, Tran C, Schneiter P, Giusti V, D'Alessio D, Tappy L. Contributions of fat and protein to the incretin effect of a mixed meal. Am J Clin Nutr. 2011 Oct;94(4):997-1003. doi: 10.3945/ajcn.111.017574. Epub 2011 Aug 17.
Clinical trial NCT03396653: Peer Support for Weight Loss Maintenance
Official title: Peer Support for Weight Loss Maintenance
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Obesity
Keywords: weight loss
weight maintenance
weight control
peer support
patient-provided care
Lead sponsor: University of Connecticut
Sponsor class: OTHER
Collaborators: name: National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
name: Stanford University
name: The Miriam Hospital
First posted: 2018-01-11
Enrollment: 849
Sex: ALL
Minimum age (years): 18
Maximum age (years): 75
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The primary aim of this study is to test the efficacy of patient-provided treatment for weight-loss maintenance.


Eligibility criteria: Inclusion Criteria:

* Age between 18-75
* Body Mass Index between 25-50
* English Speaking

Exclusion Criteria:

* Report being unable to walk 2 blocks without stopping
* Are currently participating in weight loss treatment, have a history of bariatric surgery, or lost ≥5% in the past 6-months
* Are pregnant or plan to become pregnant within 1 year
* Report a heart condition, chest pain during periods of rest or activity, or loss of consciousness on the Physical Activity Readiness Questionnaire
* Report a medical condition that could jeopardize their safety in a weight control program with diet and exercise guidelines
* Report conditions that, in the judgment of the PI, would render them unlikely to follow the protocol (e.g., relocation, dementia, unable to read and write in English)
* Have no Internet access.

Primary outcomes:
measure: Weight Change (kg)
timeFrame: Baseline to 18-months
Secondary outcomes:
measure: Blood Pressure (mmHg)
timeFrame: Baseline to 18-months
Other outcomes:
Locations:
city: Hartford
country: United States
facility: UConn's Weight Management Research Group
state: Connecticut
city: Storrs
country: United States
facility: Institute for Collaboration on Health, Intervention and Policy
state: Connecticut
Study officials:
References:
Clinical trial NCT05787353: Cardiopulmonary Rehabilitation for Post-acute COVID-19 Symptoms
Official title: Hospital- Versus Home-based Cardiopulmonary Rehabilitation for Post-acute COVID-19 Symptoms
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Cardiopulmonary
Lead sponsor: Eskisehir City Hospital
Sponsor class: OTHER
First posted: 2023-03-28
Enrollment: 88
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NON_RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The purpose of this RETROSPECTIVE study was to compare the effect of a hospital and home-based cardiopulmonary rehabilitation (CPR) program on exercise endurance and quality of life in post-acute COVID-19 patients.

88 post-acute COVID-19 patients were divided two groups according to receiving hospital (n=45) or home-based CPR (n=43)in our rehabilitation clinic between January and July 2021. Both protocols consisted of aerobic, breathing and flexibility exercises. Hospital-based CPR: three or four days per week for a total of 20 sessions. Home-based CPR: three or four days/a week over a period of six weeks. The results of six meters walk test (6MWT) for exercise endurance as a main outcome measure, and Borg-dyspnea/fatigue, the visual analog scale (VAS) for pain and the Short Form-36 (SF-36) as secondary outcome measures before and after treatment were recorded.


Eligibility criteria: Inclusion Criteria:

* being 18 years or older
* having COVID-19 treatment (home quarantine/hospital/intensive care unit) according to a positive polymerase chain reaction (PCR) test in a nasopharyngeal + oropharyngeal swab or chest computed tomography (CT)
* participating in a home-based exercise program (for 6 weeks) or hospital-based CPR (for 12-20 sessions) due to post-acute COVID-19 symptoms (fatigue, myalgia, dyspnea).

Exclusion Criteria:

* Patients who had both a negative PCR test and chest CT
* Patients who had not completed the six minute walk test (6MWT), Borg scales, Short Form-36 and Visual analog scale-pain.
* Acute COVID-19 patients (patients whose symptoms had started less than one month previous)

Primary outcomes:
measure: Exercise endurance
timeFrame: One day before exercise programme start and one day later exercise programme ends
Secondary outcomes:
measure: Dyspnea
timeFrame: One day before exercise programme start and one day later exercise programme ends
measure: Muscle fatigue
timeFrame: One day before exercise programme start and one day later exercise programme ends
measure: short form 36
timeFrame: One day before exercise programme start and one day later exercise programme ends
measure: Musculoskeletal Pain
timeFrame: One day before exercise programme start and one day later exercise programme ends
Other outcomes:
Locations:
city: Eskişehir
country: Turkey
facility: Eskişehir Osmangazi University
state: Odunpazarı
Study officials:
affiliation: Eskişehir Osmangazi University
name: Fulya Bakılan, Assoc. Prof.
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT02855853: Study of the Impact of Implicit Motor Training in a Rehabilitation Programme in Frail Elderly Subjects
Official title: Study of the Impact of Implicit Motor Training Using a Virtual Reality System and Serious Games on a Tablet Computer in a Rehabilitation Programme in Frail Elderly Subjects
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Rehabilitation Frail Elderly Subjects
Lead sponsor: Centre Hospitalier Universitaire Dijon
Sponsor class: OTHER
First posted: 2016-08-04
Enrollment: 80
Sex: ALL
Minimum age (years): 65
Standard ages: OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL

Brief summary: Even though cognitive-motor performances are impaired in frail elderly subjects compared with healthy elderly subjects, exercising cognitive-motor processes in an implicit manner can improve the carrying out of real actions in everyday life.

No training programme using virtual reality and serious games oriented towards the perception/action system has been tested in frail elderly subjects.

The expected results are:

* In the short term, greater strengthening of motor and cognitive abilities in subjects trained with the virtual reality and serious games, thanks to stimulation through action and through the underlying processes.
* In the long term (+1 and +3 months at the end of the training period) better preservation of motor and cognitive abilities in subjects who took part in the virtual reality and serious games programme.


Eligibility criteria: Inclusion Criteria:

Patients :

* Who have provided oral consent
* Enrolled in a geriatric rehabilitation programme
* Qualified as cognitively frail, that is to say a MiniMental State Examination (MMSE) score between 15 and 28 and/or for motor abilities, a walking speed less than 0.65 m/s.
* Aged ≥ 65 years
* Able to understand simple instructions

Exclusion Criteria:

Patients:

* Not covered by national health insurance
* With an extremely low cognitive status (MMSE \< 15)
* With severely impaired vision and audition (unable to discern any sensory information from the virtual reality system: music, sounds, images)
* Who are unstable when standing
* With an unsteady gait (risk of falling)
* Who cannot walk at least 10 metres
* With an acute non-stabilized cardiovascular disease
* With one or several non-consolidated fractures.
* Under guardianship

Primary outcomes:
measure: Improvement in performance at the Timed Up and Go (TUG) in the group taking part in the implicit motor training programme compared with a group having conventional motor training.
timeFrame: Change from baseline at Day0 and after 6 weeks of training
Secondary outcomes:
Other outcomes:
Locations:
city: Dijon
country: France
facility: CHU Dijon Bourgogne
Study officials:
References:
Clinical trial NCT01109953: Improving Clinical PET/CT Image Quality in Retrospectively Reconstructed Breath-Hold Images
Official title: Improving Clinical PET/CT Image Quality in Retrospectively Reconstructed Breath-Hold Images
Study type: OBSERVATIONAL
Overall status: TERMINATED
Conditions: Lung Cancer
Keywords: Lung
PET/CT scan
10-054
Lead sponsor: Memorial Sloan Kettering Cancer Center
Sponsor class: OTHER
First posted: 2010-04-23
Enrollment: 6
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Patients scheduled for whole body FDG PET/CT examination as part of their routine clinical care.

Brief summary: The patient has been referred for an FDG PET/CT scan. FDG is a form of sugar that contains a small amount of radioactivity; it is used to see the size and possible spread of cancer in the body.

Pictures of the body are taken on a machine called a PET/CT scanner. The purpose of this current study is to see if we, the investigators, can take clearer pictures of the tumor than we could with our routine scan method. This would allow us to better see how FDG is picked up by the tumor. PET/CT is presently one of the best tools for detecting cancer and determining its spread in the body. However, due to breathing motion, PET and CT images may become blurred and the location of the tumor on CT and PET images may not match. We have developed a new method that enables us to reduce image blurring and to measure the tumor more accurately on PET images. In this study we want to compare two kinds of images: those from the standard PET/CT scan, and the PET/CT scan pictures taken with our new method.

If successful, we may use this new method for clinical routine in the future.


Eligibility criteria: Inclusion Criteria:

* Participant is capable of providing written consent.
* 18 years of age or older.
* Patient with a known or suspected FDG-avid malignancy in the torso

Exclusion Criteria:

* none

Primary outcomes:
measure: To determine if our breath-hold acquisition technique can be implemented in whole-body PET/CT scans.
timeFrame: at the time of scan
Secondary outcomes:
measure: To determine if whole body PET/CT improves spatial matching of PET and CT
timeFrame: at the time of scan
Other outcomes:
Locations:
city: New York
country: United States
facility: Memorial Sloan-Kettering Cancer Center
state: New York
Study officials:
affiliation: Memorial Sloan Kettering Cancer Center
name: Heiko Schoder, MD
role: PRINCIPAL_INVESTIGATOR
References: