Clinical trial NCT06625554: Urinary Tract Infection In Assiut University Children Hospital
Official title: Antibiotic Sensitivity Pattern and Demographic Characteristics of Urinary Tract Infection In Assiut University Children Hospital
Study type: OBSERVATIONAL
Overall status: NOT_YET_RECRUITING
Conditions: Urinary Tract Infections in Children
Lead sponsor: Assiut University
Sponsor class: OTHER
First posted: 2024-10-03
Enrollment: 75
Sex: ALL
Minimum age (years): 1
Maximum age (years): 17
Standard ages: CHILD
Accepts healthy volunteers: no
Observational model: OTHER
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Antibiotic Sensitivity Pattern and Demographic Characteristics of Urinary Tract Infection In Assiut University Children Hospital

Brief summary: Antibiotic Sensitivity Pattern and Demographic Characteristics of Urinary Tract Infection In Assiut University Children Hospital

Detailed description: Urinary tract infection is the third most common serious bacterial infection in childhood and has been identified as an important risk factor for the development of progressive renal impairment and longterm consequences.

The epidemiology of UTI during childhood varies by age, gender, circumcision status, and other factors. Boys are more susceptible during the first year of life, mostly in the first 3 months, among boys, uncircumcised infants have an eightfold higher risk; due to phimosis, limiteUrinary tract infection is the third most common serious bacterial infection in childhood and has been identified as an important risk factor for the development of progressive renal impairment and longterm consequences.

The epidemiology of UTI during childhood varies by age, gender, circumcision status, and other factors. Boys are more susceptible during the first year of life, mostly in the first 3 months, among boys, uncircumcised infants have an eightfold higher risk; due to phimosis, limited retraction of the foreskin is significantly associated with an increase in UTIs in male infants, afterward, the incidence is mainly higher in girls, due to differences in anatomy .About 5% of girls and 2% of boys experience at least one incident of UTI up to the age of 7 years.

Symptoms of UTI may be minimal and non-specific in infants and small children. Febrile children not suspected of having UTI are as likely to have UTI as those who are suspected of having UTI. Therefore, diagnosis of UTI can not be made on symptomatology alone and urine examination is advocated in children with minimal suspicion of UTI.

Etiological agents of UTI are variable and usually depend on time, geographical location and age of patients. However, Escherichia coli, Proteus mirabilis, Enterobacter agglomerans, Citrobacter frreundii and Klebsiella pneumonia account for over 70% of cases.

According to sex and age, the incidence and clinical symptoms vary, and the causative organisms are different in pediatric UTI. In addition, as antibiotic-resistant pathogens change and are increased due to the abuse of antibiotics and inappropriate selection, it is necessary to select proper antibiotics in the early phase of treatment. Thus, regular antibiotic sensitivity results from the evaluation of UTI are important to improve the effectiveness of treatment.

The gold standard for the diagnosis of UTI is the detection of the pathogen in urine. The pathogen is detected and identified in urine which contributes to antibacterial treatment. Rapid administrations of empirical antibiotics are required before urine culture testing. Meanwhile, complicated UTI often increase the prevalence of inappropriate antibacterial treatment, which in turn increases antibiotic resistance ABR. In pediatric UTI, ABR is also being raised as a clinical challenge. Therefore, there is an urgent need to identify which bacterial strains in children and explore their susceptibility to commonly used antimicrobials. It could guide effective antibacterial therapy and reduce the multi-drug resistance prevalence in children.

In our study we will collect the age, sex, clinical characteristics for children, microorganism isolation and antimicrobial susceptibility profile in children who had been diagnosed with UTI.

According to sex and age, the incidence and clinical symptoms vary, and the causative organisms are different in pediatric UTI. In addition, as antibiotic-resistant pathogens change and are increased due to the abuse of antibiotics and inappropriate selection, it is necessary to select proper antibiotics in the early phase of treatment. Thus, regular antibiotic sensitivity results from the evaluation of UTI are important to improve the effectiveness of treatment.

The gold standard for the diagnosis of UTI is the detection of the pathogen in urine. The pathogen is detected and identified in urine which contributes to antibacterial treatment. Rapid administrations of empirical antibiotics are required before urine culture testing. Meanwhile, complicated UTI often increase the prevalence of inappropriate antibacterial treatment, which in turn increases antibiotic resistance ABR. In pediatric UTI, ABR is also being raised as a clinical challenge. Therefore, there is an urgent need to identify which bacterial strains in children and explore their susceptibility to commonly used antimicrobials. It could guide effective antibacterial therapy and reduce the multi-drug resistance prevalence in children.

In our study we will collect the age, sex, clinical characteristics for children, microorganism isolation and antimicrobial susceptibility profile in children who had been diagnosed with UTI.

Eligibility criteria: Inclusion Criteria:

* 1-Children over 1 month and less than 18 year of age. 2-Diagnosed cases of Urinary Tract Infection. 3-who accepted to participate in the study.

Exclusion Criteria:

* 1-neonates and patients more than 18 year. 2-children with chronic kidney diseases. 3-who refused to participate in our study.

Primary outcomes:
measure: Sample size
timeFrame: Baseline
measure: Investigations
timeFrame: Baseline
measure: History
timeFrame: Baseline
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
References:
citation: Rai GK, Upreti HC, Rai SK, Shah KP, Shrestha RM. Causative agents of urinary tract infections in children and their antibiotic sensitivity pattern: a hospital based study. Nepal Med Coll J. 2008 Jun;10(2):86-90.
citation: Fenta A, Dagnew M, Eshetie S, Belachew T. Bacterial profile, antibiotic susceptibility pattern and associated risk factors of urinary tract infection among clinically suspected children attending at Felege-Hiwot comprehensive and specialized hospital, Northwest Ethiopia. A prospective study. BMC Infect Dis. 2020 Sep 16;20(1):673. doi: 10.1186/s12879-020-05402-y.
citation: Antibiotic Sensitivity Pattern and Demographic Characteristics of Urinary Tract Infection among Hospitalized Children. Saudi J Biomed Res, 7(12): 332-338.