Clinical trial NCT02120287: Border Zone Stereotactic Radiosurgery With Bevacizumab in Patients With Glioblastoma Multiforme
Official title: Multicenter Phase II Study of Border Zone Stereotactic Radiosurgery With Bevacizumab in Patients With Recurrent or Progressive Glioblastoma Multiforme
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE2
Conditions: Glioblastoma Multiforme
Glioblastoma - Category
Keywords: Border Zone Stereotactic Radiosurgery
Bevacizumab
Recurrent Glioblastoma Multiforme
Progressive Glioblastoma Multiforme
Magnetic Resonance Spectroscopy
Glioblastoma
Brain Cancer
Brain Tumor
Radiosurgery
Lead sponsor: University of Pittsburgh
Sponsor class: OTHER
Collaborators: name: Genentech, Inc.
First posted: 2014-04-22
Enrollment: 16
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: TREATMENT

Brief summary: This is a phase II study on the usage of stereotactic Gamma Knife radiosurgery as a boost to the tumor bed border zone in conjunction with the usage of bevacizumab.

Detailed description: Glioblastoma Multiforme (GBM) is the most common primary brain tumor in adults. Unfortunately, despite aggressive surgery, radiation therapy (RT) and chemotherapy, the prognosis for this disease is poor. It is our hypothesis that GBM is a "local" disease wherein treatment failure is due to failure to eradicate tumor cells in the pathways along which the tumor eventually spreads (the "border zone").

The investigators hypothesize that treatment volume escalation will be successful at improving overall survival in patients with GBM when appropriate targeting and precision dose delivery is performed in a single treatment session. The 'border zone' of the tumor will be targeted for SRS (defined as a combination of the MRI volume of gadolinium enhancement plus up to 2 cm of the surrounding T2 volume). This represents the volume of tumor infiltrated white matter and is the route of GBM spread. Bevacizumab, a monoclonal antibody to vascular endothelial growth factor (VEGF), has been used with safety and clinical success with concomitant chemotherapy in solid tumors, including GBM.

The investigators further hypothesize that a combined approach of SRS with this VEGF inhibitor will be an effective strategy for GBM because bevacizumab will maximize the effects of radiation in the treated volume and potentially reduce radiation toxicity in the adjacent brain.

Eligibility criteria: Inclusion Criteria:

1. Histologically confirmed glioblastoma multiforme, WHO grade IV astrocytoma.
2. Prior first-line treatment with surgery or biopsy followed by fractionated radiotherapy with concurrent temozolomide-containing chemotherapy is required for glioblastoma patients. Additional prior chemotherapy is allowed, without limitation on number of recurrences.
3. An interval of at least 2 months since completion of fractionated radiotherapy.
4. Age \> 18 years
5. Life expectancy of at least 12 weeks.
6. Karnofsky Performance Status score (KPS) of ≥ 60
7. Documented recurrent disease; Disease must be evaluable, but does not need to be measurable; the target site for SRS does not need to be located in a previously-irradiated area.
8. All patients must have no restrictions to obtaining MRI with and without gadolinium contrast.
9. Adequate bone marrow, hepatic and renal function ; BUN \< 25 and Cr \< 1.7
10. Negative pregnancy test at the time of SRS in any patient who could be pregnant.
11. Willingness to forego additional therapy until evidence of disease progression

Exclusion Criteria:

1. General Medical Exclusions:

1. Current, recent (within 4 weeks of the first infusion of this study), or planned participation in an experimental drug study.
2. Active malignancy, other than superficial basal cell and superficial squamous (skin) cell, or carcinoma in situ of the cervix within last 3 years.
3. Prior radiosurgery
4. Prior intracavitary irradiation or Gliadel wafers.

2. Disease-Specific Exclusions:

1. Inability to comply with protocol or study procedures
2. Prior treatment with bevacizumab.
3. Inability to undergo MRI with and without contrast administration.

3. Bevacizumab-Specific Exclusions:

1. Inadequately controlled hypertension.
2. Prior history of hypertensive crisis or hypertensive encephalopathy.
3. New York Heart Association (NYHA) Grade II or greater congestive heart failure.
4. History of myocardial infarction or unstable angina within 6 months prior to Day 1.
5. History of stroke or transient ischemic attack within 6 months prior to Day 1.
6. Significant vascular disease within 6 months prior to Day 1.
7. History of hemoptysis within 1 month prior to Day 1.
8. Evidence of bleeding diathesis or significant coagulopathy
9. Major surgical procedure, open biopsy, or significant traumatic injury within 14 days prior to Day 1 or anticipation of need for major non -cranial surgical procedure during the course of the study.
10. Core biopsy or other minor surgical procedure, excluding placement of a vascular access device, within 7 days prior to Day 1.
11. History of abdominal fistula or gastrointestinal perforation within 6 months prior to Day 1.
12. Serious, non-healing wound, active ulcer, or untreated bone fracture.
13. Proteinuria
14. Known hypersensitivity to any component of bevacizumab
15. Pregnancy (positive pregnancy test) or lactation. Use of effective means of contraception (men and women) in subjects of child-bearing potential.

Primary outcomes:
measure: Overall Survival (OS)
timeFrame: Up to 2 years
Secondary outcomes:
measure: 6-month Progression-free Survival
timeFrame: At 6 months
measure: 6-month Overall Survival
timeFrame: At 6 months
measure: CNS Toxicity
timeFrame: Six months after SRS
measure: Tumor Response
timeFrame: Up to 2 years
measure: Potential Value of Magnetic Resonance Spectroscopy (MRS)
timeFrame: Prior to radiosurgery
measure: Karnofsky Performance Status
timeFrame: At baseline (Week 0) prior to treatment administration
measure: Barthel's Index of Activities of Daily Living Assessment
timeFrame: At baseline (Week 0) prior to treatment administration
measure: Barthel's Index of Activities of Daily Living Assessment
timeFrame: At 8 weeks
measure: Center for Epidemiological Studies Depression Scale (CES-D)
timeFrame: At baseline (Week 0) prior to treatment administration
measure: Center for Epidemiological Studies Depression Scale (CES-D)
timeFrame: At 8 weeks
measure: Functional Assessment of Cancer - General (FACT-G)
timeFrame: At baseline (Week 0) prior to treatment administration
measure: Functional Assessment of Cancer Therapy-General - General (FACT-G)
timeFrame: At 8 weeks
measure: Functional Assessment of Cancer Therapy-Brain Specific Symptom Index (FACT-BrSI)
timeFrame: At baseline (Week 0) prior to treatment administration
measure: Functional Assessment of Cancer Therapy-Brain Specific Symptom Index (FACT-BrSI)
timeFrame: At 8 weeks
Other outcomes:
Locations:
city: Pittsburgh
country: United States
facility: University of Pittsburgh
state: Pennsylvania
Study officials:
affiliation: University of Pittsburgh Medical Center
name: Ajay Niranjan, MD
role: PRINCIPAL_INVESTIGATOR
References: