Clinical trial NCT02361177: Role of Oxytocin in Telling and Detecting Lies
Official title: Role of Oxytocin in Telling and Detecting Lies
Study type: INTERVENTIONAL
Overall status: WITHDRAWN
Phase: EARLY_PHASE1
Conditions: Dyssocial Behavior
Lead sponsor: University of Texas at Austin
Sponsor class: OTHER
Collaborators: name: Harvard University
First posted: 2015-02-11
Enrollment: 0
Sex: MALE
Minimum age (years): 18
Maximum age (years): 30
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: BASIC_SCIENCE

Brief summary: The investigators are interested in the impact of intranasal oxytocin in unethical behavior.

Detailed description: The objective of this project is to further explore the role of oxytocin in moral judgment and ethical behavior. Oxytocin is a peptide hormone produced in a variety of hypothalamic neurons. It is released into the brain or brought into general circulation through sensory stimuli in a pulsatile fashion. In social psychology research, oxytocin is hypothesized to coordinate both the causes and effects of positive social interactions in a biofeedback loop.

Eligibility criteria: Inclusion Criteria:

* Male

Exclusion Criteria:

* _____ _____BP \> 130/85, HRT \> 95 (can be included at discretion of study physician/designee)

  * _____History of seizures
  * _____Neurological Disorder
  * _____Current psychiatric disorder
  * _____Previous psychiatric disorder (can be included at discretion of PI)
  * Date last episode (if \> 1 year, include; if \<1 year, at discretion of PI)
  * _____Current use of psychoactive drugs
  * _____Previous use of psychoactive drugs (can be included at discretion of PI) _____Date last medicated_____ _____Type of medication___________________________________
  * _____Current use of anticoagulants
  * _____Current use of corticosteroids
  * _____Previous head trauma (can be included at discretion of PI)
  * _____Alcoholism or substance abuse
  * _____Carcinoma of the breast or prostate
  * _____Renal or Hepatic diseases
  * _____Chronic lung diseases
  * _____Cancer
  * _____Liver problems
  * _____Hypertension/Cardiac diseases
  * _____Cardiovascular Disease
  * _____Nephritis
  * _____Diabetes (use of insulin) /Obesity
  * _____Endocrine disease or malignancy
  * _____Asthma (can be included as discretion of study physician/designee, if episodes are infrequent, nonmedicated, and no active problems at time of study)
  * Medication
  * Frequency of episodes____ _____Date of last episode_____
  * _____Migraines(can be included as discretion of study physician/designee, if episodes are infrequent, nonmedicated, and no active problems at time of study)
  * Medication _____Frequency of migraines_____ _____Date of last migraine_____
  * _____High levels of physical contact with women or children

Primary outcomes:
measure: Unethical behavior
timeFrame: 130 minutes
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
affiliation: utaustin
name: Robert A Josephs, PhD
role: PRINCIPAL_INVESTIGATOR
References:
citation: Kosfeld M, Heinrichs M, Zak PJ, Fischbacher U, Fehr E. Oxytocin increases trust in humans. Nature. 2005 Jun 2;435(7042):673-6. doi: 10.1038/nature03701.