Clinical trial NCT00286299: Treatment Effects From Aerobic Endurance Training and Maximal Strength Training in Patients Suffering From Schizophrenia
Official title: Physiological and Psychiatric Effects From Aerobic High Intensity Endurance Training and Maximal Strength Training in Patients Suffering From Schizophrenia: A Controlled Clinical Trial.
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Schizophrenia
Cardiovascular Disease
Keywords: Schizophrenia
Cardiovascular disease
Aerobic capacity
Mortality
Exercise
Lead sponsor: Norwegian University of Science and Technology
Sponsor class: OTHER
Collaborators: name: St. Olavs Hospital
name: Helse Nord-Trøndelag HF
First posted: 2006-02-03
Enrollment: 33
Sex: ALL
Minimum age (years): 20
Maximum age (years): 65
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NON_RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: This study investigates treatment effects from aerobic endurance training, maximal strength training and computer game on aerobic capacity, work efficiency and psychiatric symptoms in patients suffering from schizophrenia. The study is a controlled trial. The aim is to describe the population in respect to aerobic capacity and muscular strength. Low aerobic capacity and muscular strength are important risk factors for cardiovascular disease (CVD). The study also aim to evaluate physical and psychiatric effects from physical training. Effects from participation in physical training or computer game on symptoms, depression and quality of life will be investigated. Data will be collected between October 2005 and August 2007.


Eligibility criteria: Inclusion criteria: schizophrenia, schizotypal and delusional disorders (F20-F29) according to the international statistical classification of diseases and related health problems, 10th revision (ICD-10) prepared by the World Health Organization. Patients must have stable antipsychotic medication for six weeks prior to participation.

Exclusion criteria: coronary artery disease, chronic obstructive pulmonary disease, not being able to perform physical treadmill testing and exercise, and less than 80% compliance to the training sessions. All subjects go through a physical health examination at inclusion.

Primary outcomes:
measure: peak aerobic capacity (VO2peak)
timeFrame: Pre- and Posttest
Secondary outcomes:
measure: Positive and Negative Syndrome Scale (PANSS)
timeFrame: Pre- and Posttest
measure: Calgary Depression Scale for Schizophrenia (CDSS)
timeFrame: Pre- and Posttest
measure: The 36-item short form (SF-36)
timeFrame: Pre- and Posttest
measure: 60 Watt walking efficiency, Net efficiency
timeFrame: Pre- and Posttest
measure: Maximal strength, measured as one repetition maximum (1RM) in a incline leg press machine (Technogym)
timeFrame: Pre- and Post test
measure: Fasting blood samples, systolic and diastolic blood pressure.
timeFrame: Pre- and posttest
Other outcomes:
Locations:
city: Trondheim
country: Norway
facility: St. Olavs Hospital, Department of Psychiatry
Study officials:
affiliation: Norwegian University og Science and Technology
name: Geir Nilsberg, M.D.
role: STUDY_CHAIR
affiliation: Norwegian University of Science and Technology
name: Jørn Heggelund, M.Sc.
role: PRINCIPAL_INVESTIGATOR
References:
citation: Heggelund J, Nilsberg GE, Hoff J, Morken G, Helgerud J. Effects of high aerobic intensity training in patients with schizophrenia: a controlled trial. Nord J Psychiatry. 2011 Sep;65(4):269-75. doi: 10.3109/08039488.2011.560278. Epub 2011 Feb 18.