Clinical trial NCT05479318: A Global Approach to Tackle Cognitive Decline
Official title: A Global Approach to Tackle Cognitive Decline
Study type: OBSERVATIONAL
Overall status: ACTIVE_NOT_RECRUITING
Conditions: Dementia
Lead sponsor: Chinese University of Hong Kong
Sponsor class: OTHER
Collaborators: name: The University of New South Wales
name: University of Oxford
name: University College, London
name: Umeå University
name: Max Planck Institute for Human Development
name: National University of Singapore
First posted: 2022-07-29
Enrollment: 1502
Sex: ALL
Minimum age (years): 60
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: COHORT
Time perspective: RETROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Subjects will be retrospectively selected from 7 cohorts from Hong Kong, Australia, Singapore and Europe areas.

Brief summary: The number of people suffering from dementia in Asia (22.9 million) is more than twice the numbers in Europe (10.5 million) or the Americas (9.4 million), as recorded in the global impact of dementia in the World Alzheimer Report 2015.1 This dementia tsunami will continue to rise and the estimated number is 67 million in 2050 in Asia alone, which will be 2 to 3 times higher than the estimates for Europe (19 million) or the Americas (30 million). Devising and implementing preventive strategies against dementia is of paramount importance. The proposed project will be able to establish the associations between VRFs and cognition across cohorts with cultural, ethnical, and demographical variations. This study will generate data for evidence-based knowledge for globally implementable and effective preventive strategies for cognitive impairment and dementia.

Detailed description: Participants will be retrospectively selected from a Hong Kong Chinese cohort, a Singaporean cohort, a British cohort, two European cohorts, and an Australian cohort.

Subjects from the above listed cohorts who fit the study criteria will be selected for this study.

Demographical information, clinical, vascular risk factors, MRI images and cognitive data will be retrieved from the cohorts.

Eligibility criteria: Inclusion Criteria:

1. Elderly community-dwelling individuals aged over 60 years old;
2. those with at least 2 time points of detailed cognitive measurements, with 2-3 years of assessment interval;
3. with at least 1 timepoint of MRI (T1, FLAIR, and DTI).

Exclusion Criteria:

1. subjects with stroke, dementia, and other neurological diseases at baseline;
2. those without longitudinal cognitive data;
3. those without MRI data available.

Primary outcomes:
measure: Record of any vascular risk factors
timeFrame: Baseline
measure: Record of triglyceride level
timeFrame: Baseline
measure: Record of high-density-lipoprotein level,
timeFrame: Baseline
measure: Record of low-density-lipoprotein level,
timeFrame: Baseline
measure: Record of total cholesterol level,
timeFrame: Baseline
measure: Record of glycated hemoglobin
timeFrame: Baseline
measure: Record of fasting blood glucose
timeFrame: Baseline
measure: Record of blood pressure
timeFrame: Baseline
measure: Record of pulse
timeFrame: Baseline
measure: Change of Mini-Mental State Examination
timeFrame: Baseline and 3rd year follow up
measure: Change of Montreal Cognitive Assessment
timeFrame: Baseline, 1 yr, 2yr and 3rd year follow ups
measure: Changes of brain white matter abnormalities
timeFrame: Baseline and 1 yr, 2yr and 3rd year follow ups
Secondary outcomes:
Other outcomes:
Locations:
city: Shatin
country: Hong Kong
facility: Prince of Wales Hospital
state: N.t.
Study officials:
affiliation: Chinese University of Hong Kong
name: Bonnie Yin Ka Lam
role: PRINCIPAL_INVESTIGATOR
References: