louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT02708199: Molecular Assessment of Drug Resistance Markers in Asymptomatic Malaria Cases and Malaria Antibody Kinetic
Official title: Molecular Assessment of Drug Resistance Markers in Asymptomatic Malaria Cases in Myanmar Artemisinin Resistance Containment Zones and Malaria Antibody Kinetic Analysis
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Increased Drug Resistance
Asymptomatic Infection
Malaria
Keywords: Drug resistance malaria
Myanmar Artemisinin Resistance Containment Zone
Asymptomatic malaria
Serology
Lead sponsor: Department of Medical Research, Lower Myanmar
Sponsor class: OTHER
Collaborators: name: Kangwon National University
First posted: 2016-03-15
Enrollment: 1179
Sex: ALL
Minimum age (years): 6
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Shwegyin Township, Bago Region, Myanmar Artemisinin resistance containment Zone I.

Brief summary: Detection of the drug resistance molecular markers for falciparum and vivax in Longitudinal follow-up samples collected in Shwegyin Township, Bago Region that is Artemisinin Resistance Containment Tier I.

Detailed description: This study is longitudinal and observational cohort study to detect the drug resistance molecular markers in asymptomatic malaria infected local residents in study site. Only local residence who are not migrants, are recruited in the study and active and passive surveillance have been carried out within one year observation period. At the time of enrollment, blood film examination, rapid diagnosis test (RDT) testing have been done all together with the collection of the venous blood (about 1-2 mL) that would be used for molecular analysis later. All of the RDT or microscopy positive cases were treated according to the National Malaria Treatment Policy in Myanmar. A total of at least 1000 participants have been recruited in the study. Active case detection has been done in every three months. The venous blood were used for molecular based detection of the asymptomatic malaria infection by using High-throughout pooling strategy. All of the positive samples, (falciparum and vivax), have been checked for drug resistance molecular analaysis compared with the previously collected symptomatic malaria infection cases in the same region.

Eligibility criteria: Inclusion Criteria:

* Local resident in stud sites
* Who give informed consent
* No known tentative plan to move/ migrant elsewhere within one year

Exclusion Criteria:

* Migrant or mobile population
* Less than 6 year

Primary outcomes:
measure: Number of the Asymptomatic malaria infection
timeFrame: 2016 March
Secondary outcomes:
measure: Number of the cases that showed drug resistance molecular markers in asymptomatic malaria infection
timeFrame: 2016 April
measure: Prevalence of the different Malaria Antibody in local resident in Myanmar
timeFrame: 2016 December
Other outcomes:
Locations:
Study officials:
References:
Clinical trial NCT06883799: Association of Reaction Time and Sleep Quality in Professional Football Players
Official title: Association of Reaction Time and Sleep Quality in Professional Football Players
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Reaction Time
Sport
Football Players
Sleep Quality
Physical Fitness
Keywords: football
reaction time
sleep quality
physical activity
sport
physical fitness
Lead sponsor: University of Rzeszow
Sponsor class: OTHER
First posted: 2025-03-19
Enrollment: 80
Sex: ALL
Maximum age (years): 30
Standard ages: CHILD
ADULT
Accepts healthy volunteers: yes
Observational model: OTHER
Time perspective: OTHER
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Professional football players in the Podkarpackie Voivodeship.

Brief summary: Football players need to use their cognitive skills to choose and execute actions in reaction to various stimuli throughout a match and training. Reaction time (RT), an important component of physical fitness, is a key variable for assessing higher cognitive function in football players. For athletes, sleep is also a critical factor influencing sports performance and is widely recognized as a key indicator of overall health. The aim of this study is to assess differences in reaction time and sleep quality as well as the association between these variables in a group of professional football players and a control group. The study analyzes 40 football players (study group) and 40 healthy, non-trained individuals (control group). Sleep quality is assessed using the Pittsburgh Sleep Quality Index (PSQI), and reaction times, both simple and complex, are assessed using the AT SMART System reaction speed tester.


Eligibility criteria: Inclusion Criteria:

* Voluntary, informed written consent to participate in the study
* Minimum of 3 years of experience playing football
* Minimum of 3 training sessions per week
* Age between 18 and 30 years
* No musculoskeletal injuries within the last 6 months
* No disorders or conditions that may affect the study results

Exclusion Criteria:

* Lack of voluntary, informed written consent to participate in the study
* Less than 3 years of experience playing football
* Less than 3 training sessions per week
* Age under 18 or over 30 years
* Presence of musculoskeletal injuries within the last 6 months
* Presence of disorders or conditions that may affect the study results

Primary outcomes:
measure: Sleep quality
timeFrame: September 2024
measure: Reaction time
timeFrame: September 2024
Secondary outcomes:
Other outcomes:
Locations:
city: Rzeszów
country: Poland
facility: University of Rzeszów
Study officials:
References:
Clinical trial NCT03355599: Investigating the Benefits of a 3D Camera for Recording Healing Wound Dimensions
Official title: Investigating the Benefits of a 3D Camera for Recording Healing Wound Dimensions
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Chronic and Non-healing Wounds
Lead sponsor: Sheffield Teaching Hospitals NHS Foundation Trust
Sponsor class: OTHER
First posted: 2017-11-28
Enrollment: 30
Sex: ALL
Minimum age (years): 18
Maximum age (years): 100
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: DIAGNOSTIC

Brief summary: The study will explore whether a 3D camera data can provide a more accurate baseline measurement (compared to 2D images with manual measurement) to support better clinical decision making in referrals to tissue viability.

Detailed description: Chronic and non-healing wounds are a significant problem to manage in community and represent a significant workload in community nursing. The current management for non-healing wounds includes referral to the tissue viability service, using a 2 D photographic image with assessment information. This study will pilot the use of a 3 D camera and associated software that introduces measurement and monitoring of wounds as a specific intervention. The introduction of 3 D measurement and monitoring of wounds will be compared with usual care. With a target recruitment of 30 patients via tissue viability, the pilot will report on the feasibility of using this outcome measure and the effectiveness of monitoring on wound closure or improvement.

Eligibility criteria: Inclusion Criteria:

* Patients must have a non-healing wound and be over 18 years of age the criteria for non-healing wounds is as per 5.1 on the community nursing referral criteria when considering referral of patients to tissue viability:

'would expect that the wounds are deteriorating, chronic, non-healing or static or there are problems with the dressing regime'

Patients must be willing to provide written informed consent

Patients must have a registered Sheffield General Practitioner and be referred to tissue viability for a static or deteriorating wound

Exclusion Criteria:

* Patients with circumferential leg ulcers

Patients with deep narrow sinus where the opening is less than 10mm

Wounds on the face where the image would include the eyes or distinguishing features

Patients unable to provide written informed consent.

Primary outcomes:
measure: comparative consistency of the image
timeFrame: 1 week
measure: comparative consistency of the measurement
timeFrame: 1 week
Secondary outcomes:
Other outcomes:
Locations:
city: Sheffield
country: United Kingdom
facility: Sheffield Teaching Hospitals NHS Foundation Trust
Study officials:
affiliation: Sheffield Teaching Hospitals NHS Foundation Trust
name: Brenda King
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT03333499: the Effects of YangXinShi (YXS) on the Quality of Life and Exercise Tolerance in Patients With Chronic Heart Failure
Official title: the Effects of YangXinShi (YXS) on the Quality of Life and Exercise Tolerance in Patients With Chronic Heart Failure
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: PHASE1
Conditions: Chronic Heart Failure
Lead sponsor: Dalian University
Sponsor class: OTHER
First posted: 2017-11-07
Enrollment: 80
Sex: ALL
Minimum age (years): 18
Maximum age (years): 80
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: FACTORIAL
Primary purpose: TREATMENT

Brief summary: The investigators set out to evaluate the effects of the traditional Chinese medicinal mixture under the brand name YangXinShi (YXS) on the prognosis in patients with chronic heart failure when it is combined with the optimal combination drug treatment of heart failure.


Eligibility criteria: Inclusion Criteria:

* patients newly diagnosed with heart failure or have been diagnosed with chronic heart failure
* patients classified as NYHA II-IV (New York Heart Association)

Exclusion Criteria:

* with severe liver or renal dysfunction
* with severe systematic conditions such as infection, malignant hypertension etc.
* hemodynamic instability (arrhythmia, acute cardiac infarction, aortic dissection etc.)
* not cooperating due to psychomotor deficiency, or with contraindications for exercise testing

Primary outcomes:
measure: change in EQ-5D Questionnaire
timeFrame: from baseline to 6 months
measure: change in EQ-VAS
timeFrame: from baseline to 6 months
Secondary outcomes:
measure: change in disease specific quality of life
timeFrame: from baseline to 6 months
measure: change in heart rate variability
timeFrame: from baseline to 6 months
measure: change in left ventricular end-systolic diameters (in millimeters)
timeFrame: from baseline to 6 months
measure: change in left ventricular end-diastolic diameters (in millimeters)
timeFrame: from baseline to 6 months
measure: change in left ventricular ejection fraction (in percentage)
timeFrame: from baseline to 6 months
measure: change in exercise tolerance
timeFrame: from baseline to 6 months
measure: change in metabolic equivalents (METs)
timeFrame: from baseline to 6 months
measure: change in plasma N-terminal pro-B-type natriuretic peptide (NT-proBNP) levels (in pg/ml)
timeFrame: from baseline to 6 months
Other outcomes:
Locations:
city: Dalian
country: China
facility: Dept. of Cardiology, Affiliated Zhongshan hospital of Dalian University
state: Liaoning
Study officials:
affiliation: The Affiliated Zhongshan Hospital of Dalian University
name: qin yu, M.D., Ph.D.
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT04415099: Tibialis Posterior Fatigue and Plantar Pressure
Official title: The Effect of Tibialis Posterior Muscle Fatigue on Plantar Pressure Characteristics
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Muscle Fatigue
Keywords: Plantar pressure distribution
muscle fatigue
tibialis posterior
Lead sponsor: Hacettepe University
Sponsor class: OTHER
First posted: 2020-06-04
Enrollment: 30
Sex: ALL
Minimum age (years): 18
Maximum age (years): 35
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: SCREENING

Brief summary: The purpose of this study is to find out the changes in the measurable parameters of the dynamic and static position of the foot, caused by the tibialis posterior muscle which is activated by the fatigue protocol. The study includes 30 healthy patients whose socio-demographic and descriptive characteristics are held. The changes in the dynamic and static position of foot were measured by pedobarography whereas the level of fatigue was measured by Borg Fatigue Scale.

Detailed description: The purpose of this study is to find out the changes in the measurable parameters of the dynamic and static position of the foot, caused by the tibialis posterior muscle which is activated by the fatigue protocol. The study includes 30 healthy patients whose socio-demographic and descriptive characteristics are held. The changes in the dynamic and static position of foot were measured by pedobarography whereas the level of fatigue was measured by Borg Fatigue Scale. The variables were investigated using Shapiro-Wilk's test to determine the normality. The student's t-test for paired samples were used to analyse, means (X), standard deviations (SD), 95% confidence intervals (95%CI), mean difference and Cohen's d-effect size were calculated. The significance level was set at .05. The effect size was considered 'small' if d= .20; 'medium' if .d=.5; 'large' if d= .8.

Eligibility criteria: Inclusion Criteria:

* All participants were currently free from congenital or traumatic deformity to either lower extremity,
* A history of foot pain,
* Prior history of surgery to the foot and lower extremity
* A traumatic injury to the ankle or foot 12 months prior to the start of data collection.

Exclusion Criteria:

* Participants were excluded from this study if they had any orthopedic or neurological disorder, need to use an assistive device or orthoses.

Primary outcomes:
measure: Peak Plantar Pressures of the foot
timeFrame: 1 month
Secondary outcomes:
measure: Contact area of the foot
timeFrame: 1 month
measure: Foot axis angle
timeFrame: 1 month
measure: Subtalar angle
timeFrame: 1 month
measure: Static plantar pressure
timeFrame: 1 month
Other outcomes:
Locations:
city: Ankara
country: Turkey
facility: Pınar Kısacık
Study officials:
affiliation: Lokman Hekim Üniversitesi
name: Nilgün Bek, Prof.Dr.
role: STUDY_DIRECTOR
affiliation: Lokman Hekim Üniversitesi
name: Azize Reda Caferoglu Tunç, MSc
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT06540599: Optimizing Analgesia for Endometrial Biopsy
Official title: Optimizing Analgesia for Endometrial Biopsy: A Prospective, Randomized Comparative Study
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE4
Conditions: Analgesia
Keywords: endometrial biopsy
intrauterine lidocaine
pain management
Lead sponsor: Gaziosmanpasa Research and Education Hospital
Sponsor class: OTHER_GOV
First posted: 2024-08-06
Enrollment: 197
Sex: FEMALE
Minimum age (years): 18
Maximum age (years): 75
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: Comparison of the effectiveness of intrauterine lidocaine-paracervical block-dexketoprofen tromematol- lidocaine spray in endometrial biopsy analgesia


Eligibility criteria: Inclusion Criteria:

* women aged 18-75 needs endometrial biopsy

Exclusion Criteria:

* women with allergies to prilocaine, lidocaine or dexketoprofen trometamol
* women with a history of severe uncontrolled cardiovascular disease, diabetes mellitus, pregnancy, vaginal, cervical, or pelvic infection, cervical cancer, or severe cervical stenosis

Primary outcomes:
measure: comparing analgesics in endometrial biopsy using The Visual Analogue Scale (VAS).
timeFrame: 1 hour
Secondary outcomes:
Other outcomes:
Locations:
city: Istanbul
country: Turkey
facility: Gaziosmanpaşa Training and Research Hospital
Study officials:
References:
Clinical trial NCT07013799: Analyzing the Impact of Three Warm-Up Durations on Physical Performance in Youth Basketball Athletes.
Official title: Does Warm-Up Duration Matter? Analyzing the Impact of Three Different Warm-Up Durations on Physical Performance in Highly Trained Youth Basketball Athletes.
Study type: INTERVENTIONAL
Overall status: ENROLLING_BY_INVITATION
Phase: NA
Conditions: Jumping Performance
Speed
Agility
Keywords: Basketball
Sports Performance
Warm-up
Speed
Agility
Jumping Performance
Lead sponsor: Cardenal Herrera University
Sponsor class: OTHER
Collaborators: name: University of Valencia
First posted: 2025-06-10
Enrollment: 190
Sex: ALL
Minimum age (years): 12
Maximum age (years): 16
Standard ages: CHILD
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: This study will explore how different warm-up durations (5, 10, and 20 minutes) affect performance in youth basketball players. Using a basketball-specific routine, it will measure changes in jumping, sprinting, and agility. The goal is to find out which warm-up length best prepares young athletes for high-intensity play.

Detailed description: This study aims to examine the effects of different warm-up durations (5, 10, and 20 minutes) on physical performance in highly trained youth basketball players aged 12-16. Using a standardized basketball-specific warm-up structure (BasketUp), the study will assess how each duration influences key performance outcomes such as vertical jump, agility, and sprint speed. The goal is to determine whether a longer or shorter warm-up is more beneficial for optimizing performance in high-intensity team sports like basketball, providing practical guidance for coaches and sports professionals working with young athletes.

Eligibility criteria: Inclusion Criteria:

* At least two years of continuous membership in the squad academy.
* Participation in a minimum of 80% of all training sessions.

Exclusion Criteria:

* Any ongoing injury or discomfort reported by the participant that restricts sports participation.
* A history of injuries treated non-surgically within the last three months.
* A history of injuries treated surgically within the past nine months.

Primary outcomes:
measure: Maximum Jump Height in the Countermovement Jump (CMJ)
timeFrame: Baseline and immediately post-intervention
measure: Mean Time to Complete the Cone Drill Test
timeFrame: Baseline and immediately post-intervention
measure: Mean Sprint Time Over 14 and 20 Meters
timeFrame: Baseline and immediately post-intervention.
Secondary outcomes:
Other outcomes:
Locations:
city: Alfara del Patriarca
country: Spain
facility: University Cardenal Herrera
state: Valencia
Study officials:
affiliation: University of Valencia
name: Fernando Domínguez Navarro, Dr
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT06969599: A Cross-sectional Study on the Correlation Between Screen Usage and Sleep and Cognition in Medical Students
Official title: The Impact of Bedtime Screen Use on Sleep Quality and Cognitive Function in Medical Graduate Students: A Cross Sectional Correlation Study
Study type: OBSERVATIONAL
Overall status: NOT_YET_RECRUITING
Conditions: Sleep Quality
Keywords: sleep
Lead sponsor: Nanfang Hospital, Southern Medical University
Sponsor class: OTHER
First posted: 2025-05-14
Enrollment: 508
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: COHORT
Time perspective: CROSS_SECTIONAL
Sampling method: NON_PROBABILITY_SAMPLE
Study population: medical postgraduate

Brief summary: The aim of this study is to investigate the effects of screen use within one hour before bedtime on sleep quality and cognitive function in medical graduate students, and to verify the mediating effect of sleep quality between the two. The study adopted a cross-sectional observational design and planned to enroll 508 full-time medical graduate students. The primary endpoints were evaluated using the Pittsburgh Sleep Quality Index (PSQI) and standardized cognitive tests (N-back, ANT, etc.), while secondary endpoints included insomnia severity, anxiety/depression regulation, gut microbiota diversity, and the interaction between physical activity and sleep. Data collection includes questionnaire surveys (PSQI, ISI, GAD-7, etc.), cognitive task testing, and analysis of gut microbiota samples. The final result will provide scientific basis for improving the sleep and cognitive health of medical graduate students.


Eligibility criteria: 1. Inclusion criteria:

   1. Full time medical graduate student at Southern Medical University
   2. Age ≥ 18 years old
2. Exclusion criteria:

   1. Have taken the following medications within the past month: antibiotics, probiotics, sleeping pills, laxatives, or intestinal cleansers, etc;
   2. Serious gastrointestinal diseases (inflammatory bowel disease, Crohn's disease, gastric cancer, etc.);
   3. Recently (within one month) experienced major life events (such as the death of a relative, surgery);

Primary outcomes:
measure: Sleep questionnaire cognitive task
timeFrame: baseline
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
References:
Clinical trial NCT04012099: the Hypertrophic Scar Prevention of BMT101.
Official title: An Independent Evaluator-Blind, Dose-Escalation, Untreated-Controlled, Within-Subject, Phase 2a Therapeutic Exploratory Clinical Trial to Evaluate the Efficacy and Safety of BMT 101 Administration for the Prevention of Hypertrophic Scar
Study type: INTERVENTIONAL
Overall status: TERMINATED
Phase: PHASE2
Conditions: Hypertrophic Scar
Keywords: scar prevention
siRNA
scar
Lead sponsor: Hugel
Sponsor class: INDUSTRY
First posted: 2019-07-09
Enrollment: 20
Sex: ALL
Minimum age (years): 19
Maximum age (years): 55
Standard ages: ADULT
Accepts healthy volunteers: no
Allocation: NON_RANDOMIZED
Intervention model: SEQUENTIAL
Primary purpose: PREVENTION

Brief summary: An Independent Evaluator-Blind, Dose-Escalation, Untreated-Controlled, Within-Subject, Phase 2a Therapeutic Exploratory Clinical Trial

Detailed description: As a comparative evaluation between the control group (untreated-control) and the study group (treatment) within a subject, it was decided to assign ten subjects to each of the three dose groups.

Eligibility criteria: Inclusion Criteria:

* male and female adults aged 19-55 years
* Those who plan to undergo a revision surgery to remove hypertrophic scar resulted from a previous abdominal surgery
* Those who voluntarily signed the written consent and agreed to participate in the study.

Exclusion Criteria:

* Pregnant or lactating women
* Those with clinically significant systemic disease (e.g. diabetes, hematologic disease, allergic or immunogenic systemic skin disease)

Primary outcomes:
measure: Reducing the hypertrophic scar after scar revision surgery
timeFrame: Week 2, 6, 10, 22
measure: Safety evaluation of BMT101
timeFrame: Week 2, 6, 10, 22
Secondary outcomes:
Other outcomes:
Locations:
city: Seoul
country: Korea, Republic of
facility: Hugel
Study officials:
References: