Clinical trial NCT05803447: Analysis of Parameters Indicating the Intensity of Suicidal Behavior in Psychiatric Patients
Official title: Analysis of Parameters Indicating the Intensity of Suicidal Behavior in Patients Suffering From Depression and Schizophrenia
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Suicidal Behaviour
Cognitive Functions Confusion
Keywords: depression
schizophrenia
biochemical blood tests
oxidative stress pathway
Lead sponsor: Medical University of Bialystok
Sponsor class: OTHER
First posted: 2023-04-07
Enrollment: 120
Sex: ALL
Minimum age (years): 20
Maximum age (years): 50
Standard ages: ADULT
Accepts healthy volunteers: no
Observational model: CASE_CROSSOVER
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: The research included 120 people (58 women and 62 men) who met the criteria for being incluted in the study and who did not possess exclusion criteria.

Brief summary: The aim of this study was to analyse the level of cognitive functioning of patients with history of suicidal behaviour suffering from depression and schizophrenia, and to evaluate their oxidative stress parameters and selected biochemical parameters on the basis of bloodwork.

Detailed description: The study was conducted among 120 patients hospitalized in the Department of Psychiatry of the UMB (Medical University of Białystok). Every participant gave their own voluntary and informed written consent. Blood parameters tests were performed in the Diagnostic Laboratory of the University's Clinical Hospital and in the Department of Hygiene, Epidemiology and Ergonomics of the Medical University of Białystok. In the first stage of the study, an M.I.N.I. 7.0.2 interview was conducted with each patient to verify the intensification of suicidal behaviour. Based on the scores, the patients were classified into one of eight groups: no suicidal behaviour group (G0K, G0M); group experiencing suicidal thoughts without a tendency of implementation (G1K, G1M); group experiencing suicidal thoughts with a tendency of implementation (G2K, G2M); group after a suicide attempt (G3K, G3M).The second stage of the study consisted of biochemical blood tests, where concentrations of vitamin D3, B12, folic acid, sodium, potassium, calcium, magnesium, chlorine, total cholesterol, LDL and HDL fractions, TG and metabolites of the oxidative stress pathway were determined. The following concentrations were determined: dityrosine (AUF/mg protein), TOS (nmol H2O2 Equiv/mg protein), TAC (umol/mg protein), OSI (TOS/TAC ratio), FRAP (μmol/mg protein), GPx (mU/mg protein), SOD (mU/mg protein) CAT (nmol H2O2/min/mg protein), AOPP (nmol/mg protein), NO (nmol/mg protein), GSH (μg/mg protein). The third stage of the study consisted of the participants completing a CogState computerized test to verify their cognitive functioning. The following cognitive functions were assessed: psychomotor drive (DET), metastability of attention (IDN), verbal memory, retrieval of learned material (ISLR) and verbal learning and memory (ISL), visual learning and memory (OCL), processing speed (GMCT), visual memory including deferred retrieval (GMR), executive functions (SETS and GML), working memory (ONB, TWOB).

Eligibility criteria: Inclusion Criteria:

* patients of clinical psychiatry
* patients diagnosed with schizophrenia and depression
* age: 20-50 years
* gender: women and men

Exclusion Criteria:

* exclusion criteria were any present major medical illness (somatic or neurological disease)
* use of psychoactive substances
* decreased level of cognitive functioning
* people who do not use a computer

Primary outcomes:
measure: At the first stage, the participants were interviewed by the certified clinical psychologist. M.I.N.I. 7.0.2 interview was conducted with each patient to verify the intensification of suicidal behaviour.
timeFrame: in the first 48 hours after the hospital admission
Secondary outcomes:
measure: The second stage of the study consisted of biochemical blood tests - vitamins
timeFrame: 1 week
measure: The second stage of the study consisted of biochemical blood tests - ions
timeFrame: 1 week
measure: The second stage of the study consisted of biochemical blood tests - total cholesterol, LDL, HDL, TG
timeFrame: 1 week
measure: The second stage of the study consisted of biochemical blood tests - oxidative stress
timeFrame: 1 week
Other outcomes:
measure: The third stage of the study consisted of the participants completing a Cogstate (full name of the test) computerized test to verify their cognitive functioning. Part 1.
timeFrame: between 20 to 45 minutes
measure: The third stage of the study consisted of the participants completing a Cogstate (full name of the test) computerized test to verify their cognitive functioning. Part 2.
timeFrame: between 20 to 45 minutes
Locations:
Study officials:
References:
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