louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT05817552: Accuracy of CBCT Imaging and Intraoral Scanner in Dental Plaster Casts Digitization: A Validity and Reliability Study
Official title: Accuracy of CBCT Imaging and Intraoral Scanner in Dental Plaster Casts Digitization: A Validity and Reliability Study
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Dental Cast Digitization
Keywords: CBCT - Intraoral scanner - Cast digitization
Lead sponsor: Cairo University
Sponsor class: OTHER
First posted: 2023-04-18
Enrollment: 17
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: OTHER
Time perspective: OTHER
Sampling method: PROBABILITY_SAMPLE
Study population: Dental Plaster Casts

Brief summary: The Objective of this study is to evaluate the accuracy of CBCT and intraoral scanner, in digitization of dental plaster casts, by comparing them to desktop optical scanner as a gold standard.

Detailed description: The Objective of this study is to evaluate the accuracy of CBCT and intraoral scanner, in digitization of dental plaster casts, by comparing them to desktop optical scanner as a gold standard.

Planmeca CBCT Modality, Haron 3DISC intraoral scanner will be used as index tests, and Medit T710 desktop optical scanner will be used as the gold standard.

STL files from test scanning modalities will be compared using the surface matching software (Geomagic control X). The surface matching software will automatically register the two compared STL files together using the best-fit alignment tool and will generate the 3D compare for the surface comparison between them.

Eligibility criteria: Inclusion Criteria:

* Adult dental casts with complete dentition and/or partially edentulous regions.
* Maxillary and mandible casts are both included.
* Intact casts without voids, cracks, or visible porosities

Exclusion Criteria:

* Casts of pediatric patients.
* Completely edentulous casts.
* Casts with hypodontia, supernumerary teeth or fractured teeth.
* Casts with retainers, metallic appliances, or partial dentures.
* Casts with voids, fractures, cracks or visible porosities.

Primary outcomes:
measure: Trueness
timeFrame: 1 year
Secondary outcomes:
measure: Precision
timeFrame: 1 year
Other outcomes:
Locations:
Study officials:
References:
Clinical trial NCT06557252: The Application of the PDCA Management Model in Improving the Diagnostic Accuracy of AIG
Official title: The Application of the PDCA Management Model in Improving the Diagnostic Accuracy of AIG
Study type: OBSERVATIONAL
Overall status: NOT_YET_RECRUITING
Conditions: Autoimmune Gastritis
Lead sponsor: Ningbo No. 1 Hospital
Sponsor class: OTHER
First posted: 2024-08-16
Enrollment: 16
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Endoscopy center gastroenterologists in our hospital in 2024

Brief summary: Autoimmune gastritis is currently relatively rare in China due to its insidious onset, diverse clinical manifestations involving multiple systems such as digestive, hematological, and nervous systems, and its association with other autoimmune diseases. It can also be complicated by hyperplastic gastric polyps, gastric neuroendocrine tumors, gastric adenocarcinoma, and other diseases, making it prone to clinical misdiagnosis. As a form of gastritis in the post-Helicobacter pylori era, its detection rate has been gradually increasing with the continuous improvement of endoscopic technology in China. Applying the PDCA cycle management in disease diagnosis can significantly improve the detection rate of the disease, benefiting patients. Through the PDCA management model, this study further enhanced gastroenterologists' understanding of this disease from various aspects, aiming to improve the clinical diagnosis of autoimmune gastritis.


Eligibility criteria: Inclusion Criteria:

Endoscopy center gastroenterologists in our hospital in 2024

Exclusion Criteria:

Doctors who withdrew from the PDCA management midway and stopped undergoing gastroscopy.

Primary outcomes:
measure: Diagnostic Accuracy of AIG
timeFrame: 4months
measure: The suspected diagnosis rate of AIG
timeFrame: 4months
Secondary outcomes:
measure: Parietal Cell Antibody（PCA）
timeFrame: 4months
measure: IF-Ab
timeFrame: 4months
Other outcomes:
Locations:
city: Ningbo
country: China
facility: Ningbo first hospital
state: Zhejiang
Study officials:
References:
Clinical trial NCT05523752: Insertion of Different Supraglottic Airway Devices on Manikin
Official title: Placement of Four Different Supraglottic Airway Devices by Medicine Faculty Students: A Manikin Study
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Ventilation
Airway Management
Education
Keywords: Airway management
Supraglottic airway devices
Manikin study
education
Lead sponsor: Zonguldak Bulent Ecevit University
Sponsor class: OTHER
First posted: 2022-08-31
Enrollment: 1
Sex: ALL
Minimum age (years): 18
Maximum age (years): 30
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: NON_RANDOMIZED
Intervention model: SINGLE_GROUP
Primary purpose: OTHER

Brief summary: When tracheal intubation and face mask ventilation fail, and the insertion of supraglottic airway devices (SHA) can provide ventilation, protecting the patient from hypoxemia. Supraglottic airway devices have become an important part of difficult airway algorithms. The European Resuscitation Council Guidelines recommend supraglottic airway devices for airway management by non-specialized healthcare providers. Education through simulators contributes to the development of students without direct contact with patients. In this study, it was aimed to compare the success of placement of four different supraglottic airway devices on the manikin of term 5 students who participate to the Anesthesiology and Reanimation internship.


Eligibility criteria: Inclusion Criteria:

* Studying in medical school in term 5
* To have completed anesthesiology and reanimation internship

Exclusion Criteria:

* who do not want to participate in the study
* Students with previous experience with four airway devices

Primary outcomes:
measure: difficulty of attempts
timeFrame: during insertion procedure
Secondary outcomes:
measure: Time of attempts
timeFrame: during insertion procedure
measure: number of attempts
timeFrame: during insertion procedure
Other outcomes:
Locations:
city: Zonguldak
country: Turkey
facility: Zonguldak Bülent Ecevit University
state: Kozlu
Study officials:
References:
Clinical trial NCT02303652: Biatrial Contractility Recovery After Maze
Official title: Surgical Treatment of Concomitant Atrial Fibrillation: a Comprehensive Insight Into Biatrial Contractility Recovery.
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Atrial Fibrillation
Lead sponsor: Centro Cardiologico Monzino
Sponsor class: OTHER
First posted: 2014-12-01
Enrollment: 122
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: Patients affected by atrial fibrillation undergoing mitral valve surgery

Brief summary: This study aimed at evaluating multiple aspects of biatrial contractility recovery after modified maze procedure during mitral valve surgery.

Detailed description: Atrial fibrillation (AF) is a frequent complication in patients affected by mitral valve disease, causing systemic embolism, cardiac chamber dilation and decreased cardiac output. Cox et al. have designed the maze procedure as a surgical treatment for patients with AF in whom conventional therapy has failed and their lesion set is nowadays currently performed with different energy sources in order to surgically treat such supraventricular arrhythmia. In particular, the original maze was designed with three specific goals in mind: 1) the permanent AF ablation 2) the restoration of atrioventricular synchrony and 3) the preservation of atrial transport function (1). If , by one side, the efficacy of the procedure in reaching the first two goals are widely known, the restoration of the sinus rhythm does not always accompany the corresponding recovery of atrial mechanical "kick". If the atrial transport function fails to recover, benefits deriving from arrhythmia abolition might only be marginal, since, by one side, blood stasis in the atria persist, thus maintaining unchanged thromboembolic risk and, by the other side, heart hemodynamic performance is still impaired resulting from the loss of atrial contribution to cardiac output. Despite its relevant role for judging maze comprehensive success, atrial contractility outcome and clinical importance have not been deeply investigated. The purposes of this study were to evaluate by serial transthoracic echocardiography temporal modality of biatrial contractility restoration, predictive factors of atrial transport recovery and its possible relationship with cardiac chambers dimensions and function evolution after radiofrequency (RF) maze during mitral surgery.

Eligibility criteria: Inclusion Criteria:

* Patients affected by atrial fibrillation undergoing mitral valve surgery

Exclusion Criteria:

* Other cardiac procedures in addition to mitral valve surgery

Primary outcomes:
measure: Biatrial contractility recovery after maze
timeFrame: 24 months
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
affiliation: Centro Cardiologico Monzino Milano - Italy
name: Claudia Loardi, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT02771652: Effect of an Internet-based At-home Physical Training Protocol on Quality of Life, Fatigue, Functional Performance, Aerobic Capacity and Muscle Strength in Multiple Sclerosis Patients
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Multiple Sclerosis
Keywords: Multiple Sclerosis
Quality of Life
exercise
internet
Lead sponsor: University of Erlangen-Nürnberg
Sponsor class: OTHER
Collaborators: name: Caritas-Krankenhaus Bad Mergentheim
First posted: 2016-05-13
Enrollment: 126
Sex: ALL
Minimum age (years): 18
Maximum age (years): 65
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: In this randomised controlled trial, the feasibility and effectiveness of an internet-based exercise intervention including progressive strength and endurance training (e-training) for PwMS was investigated. Primary outcome was health-related quality of life, secondary outcomes were muscle strength, aerobic capacity and lung function, physical activity and fatigue.


Eligibility criteria: Inclusion Criteria:

* diagnosed Multiple Sclerosis (McDonald criteria),
* an EDSS score of less than or equal to 4.0,
* not less than 4 weeks of clinical stability prior to inclusion in the study,
* access to the internet.
* the taking of immunotherapeutic agents was not relevant and not monitored

Exclusion Criteria:

* primary progressive multiple sclerosis
* clinically relevant internal disease, especially cardiovascular or pulmonary disease, metabolic and orthopedic diseases

Primary outcomes:
measure: Change in Hamburg Quality of Life Questionnaire for Multiple Sclerosis (HAQUAMS)
timeFrame: Assessments took place at baseline and at 3 months
Secondary outcomes:
measure: Würzburg Fatigue Scale (WEIMuS)
timeFrame: Assessments took place at baseline, at 3 and 6 months
measure: Muscle strength lower extremities
timeFrame: Assessments took place at baseline and after 3 and 6 months
measure: Forced vital capacity
timeFrame: Assessments took place at baseline and after 3 and 6 months
measure: Aerobic capacity
timeFrame: Assessments took place at baseline and after 3 and 6 months
measure: Physical activity
timeFrame: Assessments took place at baseline and after 3 and 6 months
measure: Peak expiratory flow
timeFrame: Assessments took place at baseline and after 3 and 6 months
Other outcomes:
Locations:
Study officials:
affiliation: Caritas-Krankenhaus Bad Mergentheim
name: Matthias Mäurer, Dr.
role: PRINCIPAL_INVESTIGATOR
References:
citation: Tallner A, Tzschoppe R,Peters S, Mäurer M, Pfeifer K. Internetgestützte Bewegungsförderung bei Personen mit Multipler Sklerose. Neurologie und Rehabilitation 19(1): 35-46, 2013.
Clinical trial NCT02732652: Glycosaminoglycan Scores as Monitoring Biomarkers in Confined Renal Cell Carcinoma
Official title: Specificity and Sensitivity of Glycosaminoglycan Scores in the Early Diagnosis of Recurrent Renal Cell Carcinoma
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Carcinoma, Renal Cell
Lead sponsor: Chalmers University of Technology
Sponsor class: OTHER
Collaborators: name: Sahlgrenska University Hospital
First posted: 2016-04-11
Enrollment: 72
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Subjects referred for partial or radical nephrectomy for suspicion of renal cell carcinoma

Brief summary: In this study, a score based on glycosaminoglycan (GAG) profiling in subjects with suspicion of renal cell carcinoma (RCC) is hypothesized to distinguish malignant masses when early actionable clinical decisions are desirable. For example to diagnose early recurrence after surgical treatment; to screen population at risk of RCC; or to distinguish benign masses from RCC before surgical treatment. To this end, plasma and urine GAGs will be measured in a prospective cohort of patients referred to surgical treatment for RCC. The resulting GAG scores are then correlated to post-surgical recurrence, to post-surgical definitive diagnosis and and to tumor size if RCC. In a subset cohort of patients at high risk of RCC recurrence, plasma and urine GAGs will be monitored to observe its correlation with disease recurrence.


Eligibility criteria: Inclusion Criteria:

* Patients referred for partial or radical nephrectomy for suspicion of renal cell carcinoma
* Predicted life expectancy over 2 months
* Standard imaging evaluation 12 weeks prior to inclusion
* Planned for standard imaging within 16 weeks after start of therapy

Exclusion Criteria:

* Lack of proper compliance to accept continuous samplings.

Primary outcomes:
measure: Area under the receiver operating characteristic (ROC) curve (AUC) for the sensitivity/specificity of plasma/urine glycosaminoglycan scores in the prediction of renal cell carcinoma recurrence after surgery
timeFrame: Every 6 or 12 months after surgery up to 5 years
Secondary outcomes:
measure: Recurrence-free survival (RFS)
timeFrame: Before surgery
Other outcomes:
Locations:
city: Göteborg
country: Sweden
facility: Sahlgrenska University Hospital
Study officials:
affiliation: Chalmers University of Technology
name: Jens Nielsen, PhD
role: PRINCIPAL_INVESTIGATOR
affiliation: Sahlgrenska University Hospital
name: Sven Lundstam, M.D. PhD
role: PRINCIPAL_INVESTIGATOR
References:
citation: Gatto F, Dabestani S, Bratulic S, Limeta A, Maccari F, Galeotti F, Volpi N, Stierner U, Nielsen J, Lundstam S. Plasma and Urine Free Glycosaminoglycans as Monitoring Biomarkers in Nonmetastatic Renal Cell Carcinoma-A Prospective Cohort Study. Eur Urol Open Sci. 2022 Jun 29;42:30-39. doi: 10.1016/j.euros.2022.06.003. eCollection 2022 Aug.
Clinical trial NCT03173352: A Prospective Study on the Incidence and Related Risk Factors of Infantile Hemangioma in China
Official title: A Prospective Study on the Incidence and Related Risk Factors of Infantile Hemangioma in China
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Infantile Hemangioma
Capillary Hemangioma
Capillary Hemangiomas
Hemangioma, Capillary Infantile
Strawberry Hemangioma
Keywords: Hemangioma
Lead sponsor: Zhujiang Hospital
Sponsor class: OTHER
First posted: 2017-06-01
Enrollment: 10000
Sex: ALL
Maximum age (years): 12
Standard ages: CHILD
Accepts healthy volunteers: yes
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: All infants from the selected community

Brief summary: Infant hemangioma(IH) is the most common benign vascular tumor of infancy with the estimated incidence varies 1% to 12%.However, in China, the incidence of infant hemangioma and related epidemiological data remains unclear. So, the investigators designed the study for the following purposes: 1, to aware the incidence of infantile hemangioma and understand the related risk factorsin China; 2, to understand the clinical characteristics of infantile hemangioma and the risk factors for complications; 3, to investigate the level of knowledge, treatment options in infant hemangioma in Chinese doctors; 3, to improve the awareness of infantile hemangioma in parents and provide more advice for pregnancy counseling and eugenics.


Eligibility criteria: Inclusion Criteria:

* Chinese
* The infants within 12 months of age

Exclusion Criteria:

* Those whoes guardian does not want his data to be collected in this study

Primary outcomes:
measure: The incidence rate of infantile hemangioma in China
timeFrame: about 1 years
Secondary outcomes:
Other outcomes:
Locations:
city: Guangzhou
country: China
facility: Zhujiang Hospital
state: Guangdong
Study officials:
affiliation: Zhujiang Hospital
name: Tangde Zhang, Doctor
role: STUDY_DIRECTOR
References:
Clinical trial NCT03893552: Upper Airway Stability During Wakefulness and Sleep
Official title: Upper Airway Stability During Wakefulness and Sleep
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Sleep Apnea Syndromes
Snoring
Keywords: Negative expiratory pressure, sleep apnea, Snoring, Sleep-disordered breathing
Lead sponsor: Université Catholique de Louvain
Sponsor class: OTHER
First posted: 2019-03-28
Enrollment: 100
Sex: ALL
Minimum age (years): 18
Maximum age (years): 80
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: OTHER

Brief summary: Negative expiratory pressure is a technique that has been the focus of many studies in the last few years.

Airway response to the application of a negative expiratory pressure (NEP) can be used to detect the presence of upper airway collapsibility. In normal subjects, an increase in expiratory flow is observed while in patients with collapsible upper airway, the flow will show a transient decrease due to airway collapse.

The objectives of this study will be initially to investigate the diagnostic utility of this technique as a noninvasive measurement of the stability of the upper airway in sleep-related breathing disorders. Secondly, we aim to see the sites of airway obstructions, discovered by NEP, through nasal endoscopy. Finally, we aim at testing the utility of NEP technique in the evaluation of therapeutic response. For this purpose, we will apply it in patients before and after airway stabilization interventions like ENT surgery, oropharyngeal exercises, orthodontic mandibular advancement electrical stimulation of the hypoglossal nerve.


Eligibility criteria: Inclusion Criteria:

-

Exclusion Criteria:

* Patients with COPD

Primary outcomes:
measure: Measure of Flow limitation during NEP application
timeFrame: measurement done immediately after inclusion, one time
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
References:
Clinical trial NCT02601352: Air Pollution and Cardiometabolic Study
Official title: Characterization and Health Risk Assessment of Exposure to Source-Specific PM2.5 in Subjects in Beijing
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Cardiovascular Outcomes
Lead sponsor: Peking University
Sponsor class: OTHER
First posted: 2015-11-10
Enrollment: 45
Sex: ALL
Minimum age (years): 18
Maximum age (years): 40
Standard ages: ADULT
Accepts healthy volunteers: yes
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Living in PU community neighborhood,Beijing, China

Brief summary: The study mainly focuse on examining the subjects living in traffic polluted area and assessing the popuation health risk using disease and risk assessment models.


Eligibility criteria: Inclusion Criteria:

* Living in PU community neighborhood，Non smoker and No diseases ,and so on.

Exclusion Criteria:

* Advanced microvascular or neuropathic complications and active cardiovascular disease,and so on.

Primary outcomes:
measure: Vascular endothelial function
timeFrame: Four months
measure: Arrythmias
timeFrame: Four months
Secondary outcomes:
measure: System inflammatory
timeFrame: Four months
Other outcomes:
Locations:
city: Beijing
country: China
facility: Peking University ,School of Public Health
state: Beijing
city: Beijing
country: China
facility: Peking University
state: Beijing
Study officials:
affiliation: Peking University School of Public Health
name: Wei Huang, PhD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT02372552: Microwave Coagulation Using CROMA Electrosurgical System
Official title: Clinical Evaluation of the Safety and Performance of Microwave Coagulation by the CROMA Electrosurgical System During Resection of Complex Colorectal Polyps
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Polyp of Large Intestine
Lead sponsor: Creo Medical Limited
Sponsor class: INDUSTRY
Collaborators: name: St Mark's Hospital, Harrow, UK
First posted: 2015-02-26
Enrollment: 30
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: TREATMENT

Brief summary: This is a single centre, prospective, non-randomised pivotal clinical investigation to be undertaken at St Mark's Hospital, Harrow, UK.

Detailed description: The study will recruit 30 patients undergoing endoscopic resection of complex colorectal polyps and be used to demonstrate safety and performance of the CROMA Electrosurgical System microwave coagulation modality. Study data will complement existing data to support a CE marking application for the CROMA Electrosurgical System (combined RF and microwave modalities).

Eligibility criteria: Inclusion Criteria:

* Male or female, at least 18 years of age;
* After standard clinical work-up a benign appearing lower bowel lesion \>2cm in diameter;
* Patient or authorised representative able to comprehend and sign the Informed Consent prior to enrolment in the study.

Exclusion Criteria:

* Aged \<18 years of age;
* Pregnant or lactating females;
* Lower bowel lesions \<2cm in diameter;
* Patients receiving regular systemic steroids;
* Patients who are immuno-compromised (either acquired or congenital);
* Patients with a known coagulopathy (either acquired or congenital);
* Patients on anti-platelet therapy at the time of the procedure, apart from low dose (75mg) aspirin alone;
* Concurrent participation in another experimental intervention or drug study;
* Unwilling or unable to provide informed consent.

Primary outcomes:
measure: Pre-coagulation of visible blood vessels and treatment of actively bleeding vessels, ≤1mm in diameter.
timeFrame: Peri-operative
Secondary outcomes:
measure: Safety: assessed using reported Adverse Events
timeFrame: 28 weeks
measure: Intra-operative complications
timeFrame: Intra-operative
measure: Post-procedural complications
timeFrame: 28 weeks
measure: Clinical outcome
timeFrame: 28 weeks
Other outcomes:
Locations:
city: Harrow
country: United Kingdom
facility: Wolfson Unit for Endoscopy, St Mark's Hospital
state: Middlesex
Study officials:
affiliation: St. Mark's Hospital
name: Brian Saunders, Professor
role: PRINCIPAL_INVESTIGATOR
References: