Clinical trial NCT03104413: A Study to Assess the Efficacy and Safety of Risankizumab in Participants With Moderately to Severely Active Crohn's Disease Who Failed Prior Biologic Treatment
Official title: A Multicenter, Randomized, Double-Blind, Placebo-Controlled Induction Study to Assess the Efficacy and Safety of Risankizumab in Subjects With Moderately to Severely Active Crohn's Disease Who Failed Prior Biologic Treatment
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE3
Conditions: Crohn's Disease
Keywords: ABBV-066
BI 655066
Lead sponsor: AbbVie
Sponsor class: INDUSTRY
First posted: 2017-04-07
Enrollment: 618
Sex: ALL
Minimum age (years): 16
Maximum age (years): 80
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The objective of Study M15-991 is to evaluate the efficacy and safety of risankizumab versus placebo during induction therapy in participants with moderately to severely active CD.


Eligibility criteria: Inclusion Criteria:

* Male or female aged \>=18 to \<= 80 years, or minimum age of adult consent according to local regulations, at the Baseline Visit. Where locally permissible, participants 16 to \< 18 years of age who meet the definition of Tanner stage 5 for development at the Baseline Visit.
* Confirmed diagnosis of CD for at least 3 months prior to Baseline.
* Crohn's disease activity index (CDAI) score 220 - 450 at Baseline.
* Confirmed diagnosis of moderate to severe CD as assessed by stool frequency (SF), abdominal pain (AP) score, and Simple Endoscopic Score for Crohn's Disease (SES-CD).
* Demonstrated intolerance or inadequate response to biologic therapy for CD.
* If female, participant must meet the contraception recommendations.

Exclusion Criteria:

* Participant with a current diagnosis of ulcerative colitis or indeterminate colitis.
* Participants with unstable doses of concomitant Crohn's disease therapy.
* Receipt of Crohn's disease approved biologic agents (infliximab, adalimumab, certolizumab, vedolizumab, natalizumab within 8 weeks prior to Baseline or ustekinumab within 12 weeks prior to Baseline), or any investigational biologic or other agent or procedure within minimally 35 days or 5 half-lives prior to Baseline, whichever is longer.
* Prior exposure to p19 inhibitors (e.g., risankizumab).
* Complications of Crohn's disease.
* Having an ostomy or ileoanal pouch.
* Known active Coronavirus Disease 2019 (COVID-19) infection.

Primary outcomes:
measure: US Specific: Percentage of Participants With Crohn's Disease Activity Index (CDAI) Clinical Remission
timeFrame: Week 12
measure: US Specific: Percentage of Participants With Endoscopic Response
timeFrame: Week 12
measure: Global Outside of US: Percentage of Participants With Clinical Remission
timeFrame: Week 12
measure: Global Outside of US: Percentage of Participants With Endoscopic Response
timeFrame: Week 12
Secondary outcomes:
measure: US Specific: Percentage of Participants With Clinical Remission
timeFrame: Week 12
measure: US Specific: Percentage of Participants With Crohn's Disease Activity Index (CDAI) Clinical Response
timeFrame: Week 4
measure: US Specific: Percentage of Participants With Crohn's Disease Activity Index (CDAI) Clinical Response
timeFrame: Week 12
measure: US Specific: Change From Baseline of Functional Assessment of Chronic Illness Therapy (FACIT)-Fatigue
timeFrame: Week 12
measure: US Specific: Percentage of Participants With Crohn's Disease Activity Index (CDAI) Clinical Remission
timeFrame: Week 4
measure: US Specific: Percentage of Participants With CDAI Clinical Response and Endoscopic Response
timeFrame: Week 12
measure: US Specific: Percentage of Participants With Stool Frequency (SF) Remission
timeFrame: Week 12
measure: US Specific: Percentage of Participants With Abdominal Pain (AP) Remission
timeFrame: Week 12
measure: US Specific: Percentage of Participants With Endoscopic Remission
timeFrame: Week 12
measure: US Specific: Percentage of Participants With Enhanced Clinical Response
timeFrame: Week 4
measure: US Specific: Percentage of Participants With Ulcer-Free Endoscopy
timeFrame: Week 12
measure: US Specific: Percentage of Participants With Enhanced Clinical Response
timeFrame: Week 12
measure: US Specific: Percentage of Participants With Resolution of Extra-Intestinal Manifestations (EIMs), in Participants With EIMs at Baseline Baseline
timeFrame: Week 12
measure: US Specific: Percentage of Participants With CD-Related Hospitalization
timeFrame: Up to Week 12
measure: US Specific: Percentage of Participants Without Draining Fistulas in Participants With Draining Fistulas at Baseline
timeFrame: Week 12
measure: Global Outside of US: Percentage of Participants With Crohn's Disease Activity Index (CDAI) Clinical Remission
timeFrame: Week 12
measure: Global Outside of US: Percentage of Participants With Crohn's Disease Activity Index (CDAI) Clinical Response
timeFrame: Week 4
measure: Global Outside of US: Percentage of Participants With Clinical Remission
timeFrame: Week 4
measure: Global Outside of US: Percentage of Participants With Crohn's Disease Activity Index (CDAI) Clinical Response
timeFrame: Week 12
measure: Global Outside of US: Change From Baseline of Functional Assessment of Chronic Illness Therapy (FACIT)-Fatigue
timeFrame: Week 12
measure: Global Outside of US: Change From Baseline in Inflammatory Bowel Disease Questionnaire (IBDQ) Total Score
timeFrame: Week 12
measure: Global Outside of US: Percentage of Participants With Enhanced Clinical Response and Endoscopic Response
timeFrame: Week 12
measure: Global Outside of US:: Percentage of Participants With Endoscopic Remission
timeFrame: Week 12
measure: Global Outside of US: Percentage of Participants With Enhanced Clinical Response
timeFrame: Week 4
measure: Global Outside of US: Percentage of Participants With Ulcer-Free Endoscopy
timeFrame: Week 12
measure: Global Outside of US: Percentage of Participants With Enhanced Clinical Response
timeFrame: Week 12
measure: Global Outside of US: Percentage of Participants With Resolution of Extra-Intestinal Manifestations (EIMs), in Participants With EIMs at Baseline Baseline
timeFrame: Week 12
measure: Global Outside of US: Percentage of Participants With CD-Related Hospitalization
timeFrame: Week 12
measure: Global Outside of US: Percentage of Participants Without Draining Fistulas in Participants With Draining Fistulas at Baseline
timeFrame: Week 12
measure: Global Outside of US: Change From Baseline in Work Productivity and Impairment Questionnaire - Crohn's Disease (WPAI-CD) Overall Work Impairment
timeFrame: Week 12
measure: Global Outside of US: Change From Baseline in Short Form-36 (SF-36) Physical Component Summary (PCS) Score
timeFrame: Week 12
Other outcomes:
Locations:
city: Phoenix
country: United States
facility: Phoenix VA Health Care System /ID# 162261
state: Arizona
city: Scottsdale
country: United States
facility: HonorHealth Research Institute - Shea /ID# 165825
state: Arizona
city: Tempe
country: United States
facility: Digestive Disease Consultants, A Division of Arizona Digestive Health, P.C /ID# 211882
state: Arizona
city: Tucson
country: United States
facility: University of Arizona /ID# 158305
state: Arizona
city: Little Rock
country: United States
facility: Duplicate_Atria Clinical Research /ID# 164504
state: Arkansas
city: Coronado
country: United States
facility: Southern California Res. Ctr. /ID# 211989
state: California
city: Huntington Beach
country: United States
facility: Newport Huntington Medica /ID# 213034
state: California
city: La Jolla
country: United States
facility: UC San Diego Health Systems /ID# 155576
state: California
city: Los Alamitos
country: United States
facility: United Medical Doctors /ID# 207887
state: California
city: Los Angeles
country: United States
facility: TLC Clinical Research Inc /ID# 212501
state: California
city: Los Angeles
country: United States
facility: Gastrointestinal Biosciences Clinical Trials, LLC /ID# 162655
state: California
city: Murrieta
country: United States
facility: United Medical Doctors - Murrieta /ID# 158278
state: California
city: Colorado Springs
country: United States
facility: Peak Gastroenterology Associates, PC /ID# 165832
state: Colorado
city: Lone Tree
country: United States
facility: Rocky Mountain Pediatric Gastroenterology /ID# 207171
state: Colorado
city: Danbury
country: United States
facility: Western Connecticut Medical Group /ID# 165874
state: Connecticut
city: Brandon
country: United States
facility: Seffner Premier Health Care, PA /ID# 162259
state: Florida
city: Clearwater
country: United States
facility: Clinical Research of West Florida, Inc /ID# 205864
state: Florida
city: Clearwater
country: United States
facility: Clinical Research of West Florida, Inc /ID# 208127
state: Florida
city: Clermont
country: United States
facility: South Lake Pain Institute, Inc /ID# 162798
state: Florida
city: DeBary
country: United States
facility: Omega Research Maitland, LLC /ID# 171080
state: Florida
city: Doral
country: United States
facility: Universal Axon Clinical Research /ID# 165426
state: Florida
city: Kissimmee
country: United States
facility: SIH Research Mumtaz, Inc /ID# 163081
state: Florida
city: Lighthouse Point
country: United States
facility: Alliance Medical Research /ID# 163834
state: Florida
city: Maitland
country: United States
facility: Cfagi Llc /Id# 202482
state: Florida
city: Miami
country: United States
facility: University of Miami /ID# 155011
state: Florida
city: Miami
country: United States
facility: Vista Health Research, LLC /ID# 212828
state: Florida
city: Miami
country: United States
facility: ITB Research /ID# 161278
state: Florida
city: Miami
country: United States
facility: Coral Research Clinic /ID# 158330
state: Florida
city: Miami
country: United States
facility: South Florida Research Ph I-IV, Inc. /ID# 161825
state: Florida
city: Naples
country: United States
facility: Gastroenterology Group Naples /ID# 165192
state: Florida
city: New Port Richey
country: United States
facility: Advanced Research Institute, Inc /ID# 161973
state: Florida
city: Orlando
country: United States
facility: Endoscopic Research, Inc. /ID# 205903
state: Florida
city: Palmetto Bay
country: United States
facility: IMIC Inc. Medical Research /ID# 154944
state: Florida
city: Tampa
country: United States
facility: Clinical Research Trials of Florida, Inc. /ID# 201606
state: Florida
city: Atlanta
country: United States
facility: Atlanta Gastro Assoc /ID# 154755
state: Georgia
city: Macon
country: United States
facility: Gastroenterology Associates of Central Georgia, LLC /ID# 154865
state: Georgia
city: Chicago
country: United States
facility: Northwestern University Division of GI/Hepatology /ID# 158250
state: Illinois
city: Chicago
country: United States
facility: The University of Chicago Medical Center /ID# 157113
state: Illinois
city: Evanston
country: United States
facility: NorthShore University HealthSystem /ID# 158254
state: Illinois
city: Oak Lawn
country: United States
facility: Southwest Gastroenterology /ID# 164764
state: Illinois
city: Topeka
country: United States
facility: Cotton-O'Neil Clinical Res Ctr /ID# 154753
state: Kansas
city: Lexington
country: United States
facility: University of Kentucky Chandler Medical Center /ID# 157109
state: Kentucky
city: Louisville
country: United States
facility: University of Louisville /ID# 210523
state: Kentucky
city: Baton Rouge
country: United States
facility: Gastroenterology Associates LLC - Jefferson Hwy /ID# 161970
state: Louisiana
city: Houma
country: United States
facility: Houma Digestive Health Special /ID# 158253
state: Louisiana
city: New Orleans
country: United States
facility: Delricht Research /ID# 206567
state: Louisiana
city: New Orleans
country: United States
facility: Nola Research Works, LLC /ID# 161271
state: Louisiana
city: Shreveport
country: United States
facility: Louisana Research Center, LLC /ID# 162239
state: Louisiana
city: Chevy Chase
country: United States
facility: MGG Group Co, Inc.Chevy Chase Clinical Research /ID# 154846
state: Maryland
city: Columbia
country: United States
facility: Gastro Center of Maryland /ID# 164766
state: Maryland
city: Troy
country: United States
facility: Center for Digestive Health /ID# 154697
state: Michigan
city: Wyoming
country: United States
facility: Gastroenterology Associates of Western Michigan, PLC d.b.a. West Michigan Clinic /ID# 161267
state: Michigan
city: Rochester
country: United States
facility: Mayo Clinic - Rochester /ID# 163084
state: Minnesota
city: Omaha
country: United States
facility: University of Nebraska Medical Center /ID# 210056
state: Nebraska
city: Las Vegas
country: United States
facility: Las Vegas Medical Research /ID# 160167
state: Nevada
city: Las Vegas
country: United States
facility: Revival Research Institute, Inc /ID# 210986
state: Nevada
city: Brooklyn
country: United States
facility: NY Scientific /ID# 158272
state: New York
city: Burnt Hills
country: United States
facility: Saratoga Schenectady Gastroenterology Associates - Burnt Hills /ID# 213446
state: New York
city: Fresh Meadows
country: United States
facility: Intercity Advanced Gastroentertology Center /ID# 215204
state: New York
city: Great Neck
country: United States
facility: Duplicate_Long Island Clinical Research /ID# 154843
state: New York
city: New Hyde Park
country: United States
facility: Digestive Disease Care /ID# 211776
state: New York
city: New Hyde Park
country: United States
facility: North Shore University Hospital /ID# 168734
state: New York
city: New York
country: United States
facility: NYU Langone Medical Center /ID# 160166
state: New York
city: New York
country: United States
facility: Weill Cornell Medicine /ID# 165856
state: New York
city: New York
country: United States
facility: Icahn School of Medicine at Mount Sinai - The Mount Sinai Medical Center /ID# 165610
state: New York
city: New York
country: United States
facility: Columbia Univ Medical Center /ID# 167545
state: New York
city: New York
country: United States
facility: Lenox Hill Hospital /ID# 168466
state: New York
city: North Massapequa
country: United States
facility: DiGiovanna Institute for Medical Education & Research /ID# 171130
state: New York
city: Charlotte
country: United States
facility: Atrium Health Carolinas Medical Center /ID# 158364
state: North Carolina
city: Kinston
country: United States
facility: Vidant Multispecialty Clinic - Kinston /ID# 161109
state: North Carolina
city: Raleigh
country: United States
facility: Wake Radiology UNC REX Healthcare - Raleigh Office /ID# 154891
state: North Carolina
city: Fargo
country: United States
facility: Plains Clinical Research Center, LLC /ID# 169712
state: North Dakota
city: Cincinnati
country: United States
facility: Tri-State Endoscopy /ID# 154939
state: Ohio
city: Cleveland
country: United States
facility: Cleveland Clinic Main Campus /ID# 209225
state: Ohio
city: Columbus
country: United States
facility: The Ohio State University /ID# 164706
state: Ohio
city: Columbus
country: United States
facility: Optimed Research, Ltd. /ID# 167877
state: Ohio
city: Dayton
country: United States
facility: Hometown Urgent Care and Resea /ID# 170447
state: Ohio
city: Mentor
country: United States
facility: Great Lakes Medical Research, LLC /ID# 201774
state: Ohio
city: Oklahoma City
country: United States
facility: Hightower Clinical /ID# 211992
state: Oklahoma
city: Oklahoma City
country: United States
facility: Digestive Disease Specialists /ID# 170772
state: Oklahoma
city: Tulsa
country: United States
facility: Adult Gastroenterology Associates - Gen 1 Research /ID# 208857
state: Oklahoma
city: Portland
country: United States
facility: Northwest Gastroenterology Clinic /ID# 158255
state: Oregon
city: Hershey
country: United States
facility: PennState Milton S.Hershey Med /ID# 154894
state: Pennsylvania
city: Pittsburgh
country: United States
facility: Children's Hospital of Pittsburgh of UPMC /ID# 212543
state: Pennsylvania
city: Wyomissing
country: United States
facility: Digestive Disease Associates, LTD /ID# 208296
state: Pennsylvania
city: Charleston
country: United States
facility: Medical University of South Carolina /ID# 212859
state: South Carolina
city: Greenville
country: United States
facility: Gastroenterology Associates, P.A. of Greenville /ID# 154919
state: South Carolina
city: Rapid City
country: United States
facility: Rapid City Medical Center - GI Research /ID# 163835
state: South Dakota
city: Germantown
country: United States
facility: Gastro One /ID# 154757
state: Tennessee
city: Johnson City
country: United States
facility: East Tennessee Research Institute /ID# 168735
state: Tennessee
city: Memphis
country: United States
facility: Duplicate_Clinical Neuroscience Solutions, Inc /ID# 164179
state: Tennessee
city: Nashville
country: United States
facility: Vanderbilt University Medical Center /ID# 157110
state: Tennessee
city: Arlington
country: United States
facility: TX Clinical Research Institute /ID# 159396
state: Texas
city: Baytown
country: United States
facility: Inquest Clinical Research /ID# 165696
state: Texas
city: Cedar Park
country: United States
facility: Texas Digestive Disease Consultants /ID# 209781
state: Texas
city: Cedar Park
country: United States
facility: Texas Digestive Disease Consultants /ID# 209945
state: Texas
city: Garland
country: United States
facility: DHAT Research Institute /ID# 158199
state: Texas
city: Houston
country: United States
facility: Vilo Research Group Inc /ID# 207654
state: Texas
city: Houston
country: United States
facility: CliniCore International, LLC /ID# 158191
state: Texas
city: Houston
country: United States
facility: Baylor College of Medicine - Baylor Medical Center /ID# 158194
state: Texas
city: Houston
country: United States
facility: Precision Research Institute, LLC /ID# 201072
state: Texas
city: Houston
country: United States
facility: Centex Studies, Inc. - Houston /ID# 201218
state: Texas
city: San Antonio
country: United States
facility: Clinical Associates in Research Therapeutics of America, LLC /ID# 161307
state: Texas
city: San Antonio
country: United States
facility: Southern Star Research Institute, LLC /ID# 168772
state: Texas
city: Temple
country: United States
facility: Baylor Scott & White Medical Center- Temple /ID# 204129
state: Texas
city: Tyler
country: United States
facility: Tyler Research Institute, LLC /ID# 166795
state: Texas
city: Victoria
country: United States
facility: Gastro Health & Nutrition - Victoria /ID# 164284
state: Texas
city: Bountiful
country: United States
facility: HP Clinical Research /ID# 162992
state: Utah
city: Ogden
country: United States
facility: Advanced Research Institute /ID# 154922
state: Utah
city: West Jordan
country: United States
facility: Velocity Clinical Research - Salt Lake City /ID# 161775
state: Utah
city: Richmond
country: United States
facility: Hunter Holmes McGuire VA Medical Center /ID# 159977
state: Virginia
city: Bellevue
country: United States
facility: Washington Gastroenterology Associates /ID# 162101
state: Washington
city: Seattle
country: United States
facility: Virginia Mason - Seattle Orthapedics /ID# 155577
state: Washington
city: Morgantown
country: United States
facility: WVU Medicine /ID# 167942
state: West Virginia
city: Ciudad Autonoma de Buenos Aire
country: Argentina
facility: Hospital Britanico de Buenos Aires /ID# 168081
state: Ciuadad Autonoma De Buenos Aires
city: Ciudad Autonoma de Buenos Aire
country: Argentina
facility: Cemic /Id# 168082
state: Ciuadad Autonoma De Buenos Aires
city: Rosario
country: Argentina
facility: Hospital Provincial del Centenario /ID# 170904
state: Santa Fe
city: Cordoba
country: Argentina
facility: Hospital Privado Univesitario /ID# 168080
city: South Brisbane
country: Australia
facility: Mater Misericordiae Limited /ID# 167216
state: Queensland
city: Southport
country: Australia
facility: Griffith University /ID# 212631
state: Queensland
city: Elizabeth Vale
country: Australia
facility: Lyell McEwin Hospital /ID# 211364
state: South Australia
city: Camberwell
country: Australia
facility: Emeritus Research /ID# 213510
state: Victoria
city: Footscray
country: Australia
facility: Footscray Hospital /ID# 211362
state: Victoria
city: Sankt Poelten
country: Austria
facility: Universitaetsklinikum St. Poelten /ID# 166423
state: Niederoesterreich
city: Graz
country: Austria
facility: Duplicate_LKH-Univ. Klinikum Graz /ID# 158134
state: Steiermark
city: Vienna
country: Austria
facility: Krankenhaus der Barmherzigen Brueder Wien /ID# 211418
state: Wien
city: Vienna
country: Austria
facility: Duplicate_Medical University of Vienna /ID# 158135
state: Wien
city: Витебск
country: Belarus
facility: Vitebsk Regional Advanced Clin /ID# 204807
city: Mechelen
country: Belgium
facility: AZ Sint-Maarten /ID# 212280
state: Antwerpen
city: Brussels
country: Belgium
facility: ULB Hospital Erasme /ID# 157386
state: Bruxelles-Capitale
city: Woluwe-Saint-Lambert
country: Belgium
facility: UCL Saint-Luc /ID# 157384
state: Bruxelles-Capitale
city: Gent
country: Belgium
facility: UZ Gent /ID# 157383
state: Oost-Vlaanderen
city: Bonheiden
country: Belgium
facility: Imelda Ziekenhuis /ID# 157381
city: Gent
country: Belgium
facility: AZ Maria Middelares /ID# 212871
city: Kortrijk
country: Belgium
facility: AZ Groeninge /ID# 212571
city: Merksem
country: Belgium
facility: ZNA - Jan Palfijn /ID# 212822
city: Banja Luka
country: Bosnia and Herzegovina
facility: University Clinical Centre of the Republic of Srpska /ID# 157710
state: Republika Srpska
city: Banja Luka
country: Bosnia and Herzegovina
facility: University Clinical Centre of the Republic of Srpska /ID# 165018
state: Republika Srpska
city: Sarajevo
country: Bosnia and Herzegovina
facility: Clinical Center University of Sarajevo /ID# 165132
city: Pleven
country: Bulgaria
facility: UMHAT Dr Georgi Stranski EAD /ID# 203975
city: Plovdiv
country: Bulgaria
facility: University Multiprofile Hospit /ID# 165697
city: Sofia
country: Bulgaria
facility: Second Multiprofile Hospital f /ID# 165699
city: Sofia
country: Bulgaria
facility: Acibadem City Clinic UMHAT Tokuda /ID# 165698
city: Sofia
country: Bulgaria
facility: UMHAT Sveti Ivan Rilski /ID# 204713
city: Sofia
country: Bulgaria
facility: UMHAT Tsaritsa Joanna - ISUL /ID# 211241
city: Stara Zagora
country: Bulgaria
facility: MHAT Trakia /ID# 201665
city: Varna
country: Bulgaria
facility: University Multiprofile Hospit /ID# 167576
city: Calgary
country: Canada
facility: University of Calgary - Heritage Medical Research Clinic /ID# 157156
state: Alberta
city: Edmonton
country: Canada
facility: Allen Whey Khye Lim Professional Corporation /ID# 169766
state: Alberta
city: Edmonton
country: Canada
facility: University of Alberta - Zeidler Ledcor Centre /ID# 157100
state: Alberta
city: Edmonton
country: Canada
facility: Covenant Health /ID# 161636
state: Alberta
city: New Westminster
country: Canada
facility: Fraser Clinical Trials Inc /ID# 159057
state: British Columbia
city: Vancouver
country: Canada
facility: GIRI Gastrointestinal Research Institute /ID# 157097
state: British Columbia
city: Victoria
country: Canada
facility: Percuro Clinical Research, Ltd /ID# 161635
state: British Columbia
city: Halifax
country: Canada
facility: QEII - Health Sciences Centre /ID# 157089
state: Nova Scotia
city: Halifax
country: Canada
facility: IWK Health Center /ID# 165909
state: Nova Scotia
city: London
country: Canada
facility: London Health Sciences Center /ID# 157162
state: Ontario
city: North Bay
country: Canada
facility: Scott Shulman Medicine Professional Corporation /ID# 165910
state: Ontario
city: Sudbury
country: Canada
facility: Medicor Research Inc /ID# 157151
state: Ontario
city: Vaughan
country: Canada
facility: Toronto Digestive Disease Asso /ID# 157159
state: Ontario
city: Greenfield Park
country: Canada
facility: CISSS de la Monteregie /ID# 161634
state: Quebec
city: Montreal
country: Canada
facility: CIUSSS de l'est de l'Ile-de-Montreal - Hopital Maisonneuve-Rosemont /ID# 159058
state: Quebec
city: Montreal
country: Canada
facility: CHUM - Centre hospitalier de l'Universite de Montréal /ID# 167070
state: Quebec
city: Montreal
country: Canada
facility: Montreal General Hospital - McGill University Health Center /ID# 157086
state: Quebec
city: Santiago
country: Chile
facility: Complejo Asistencial Dr. Sotero del Rio /ID# 169383
state: Region Metropolitana De Santiago
city: Santiago
country: Chile
facility: Servicio de Salud Occidente Hospital San Juan de Dios /ID# 171121
state: Region Metropolitana De Santiago
city: Viña del Mar
country: Chile
facility: Centro de Investigaciones Clínicas Viña del Mar /ID# 203585
state: Valparaíso
city: Concepción
country: Chile
facility: Hospital Guillermo Grant Benavente de Concepción /ID# 210758
city: Talcahuano
country: Chile
facility: Hospital Las Higueras /ID# 167091
city: Guangzhou
country: China
facility: The Sixth Affiliated Hosp Sun /ID# 210783
state: Guangdong
city: Wuhan
country: China
facility: Tongji Hospital Tongji Medical College Huazhong University of Science and Techno /ID# 210857
state: Hubei
city: Wuhan
country: China
facility: Union Hospital affiliated to Tongji Medical College of Huazhong University of Sc /ID# 211040
state: Hubei
city: Nanchang
country: China
facility: The First Affiliated Hospital of Nanchang University /ID# 211035
state: Jiangxi
city: Shanghai
country: China
facility: Ruijin Hospital, Shanghai Jiaotong University School of Medicine /ID# 210842
state: Shanghai
city: Shanghai
country: China
facility: Renji Hospital, Shanghai Jiaotong University School of Medicine /ID# 210706
state: Shanghai
city: Hangzhou
country: China
facility: Sir Run Run Shaw Hospital Zhejiang University School of Medicine /ID# 210626
state: Zhejiang
city: Chengdu
country: China
facility: West China Hospital, Sichuan University /ID# 210888
city: Pudong New District
country: China
facility: Shanghai East Hospital /ID# 212671
city: Tianjin
country: China
facility: Duplicate_Tianjin Med Univ General Hosp /ID# 210925
city: Medellin
country: Colombia
facility: Instituto de Coloproctologia /ID# 158740
state: Antioquia
city: Medellín
country: Colombia
facility: Hospital Pablo Tobon Uribe /ID# 158732
state: Antioquia
city: Bogota
country: Colombia
facility: Hospital Univ San Ignacio /ID# 158737
state: Cundinamarca
city: Zagreb
country: Croatia
facility: Duplicate_Klinicka bolnica Dubrava Zagreb /ID# 157719
state: Grad Zagreb
city: Zagreb
country: Croatia
facility: Klinicki bolnicki centar Sestre milosrdnice /ID# 157720
state: Grad Zagreb
city: Zagreb
country: Croatia
facility: Klinicki bolnicki centar Zagreb /ID# 157703
state: Grad Zagreb
city: Osijek
country: Croatia
facility: UHC Osijek /ID# 157704
state: Osjecko-baranjska Zupanija
city: Split
country: Croatia
facility: Klinicki bolnicki centar Split /ID# 157705
state: Splitsko-dalmatinska Zupanija
city: Zadar
country: Croatia
facility: Zadar General Hospital /ID# 157706
city: Prague 4
country: Czechia
facility: Duplicate_Institut klinicke a experimentalni mediciny (IKEM) /ID# 165479
state: Praha 4
city: Hradec Kralove
country: Czechia
facility: Hepato-Gastroenterologie HK, s.r.o. /ID# 163218
city: Olomouc
country: Czechia
facility: CTCenter MaVe s.r.o. /ID# 163215
city: Pardubice
country: Czechia
facility: Nemocnice Pardubickeho kraje, a.s. /ID# 163219
city: Praha
country: Czechia
facility: Nemocnice Milosrdnych sester sv. Karla Boromejskeho v Praze /ID# 211304
city: Praha
country: Czechia
facility: Axon Clinical, s.r.o. /ID# 163216
city: Praha
country: Czechia
facility: Thomayerova nemocnice /ID# 162942
city: Praha
country: Czechia
facility: ResTrial s.r.o. /ID# 211074
city: Praha
country: Czechia
facility: NH Hospital a.s. /ID# 211073
city: Hvidovre
country: Denmark
facility: Kobenhavns Universitet - Hvidovre Hospital (HH) /ID# 155535
state: Hovedstaden
city: Aarhus N
country: Denmark
facility: Aarhus University Hospital /ID# 155534
state: Midtjylland
city: Roskilde
country: Denmark
facility: Sjællands Universitetshospital, Roskilde /ID# 155537
state: Sjælland
city: Nyborg
country: Denmark
facility: Sygehusenheden Nyborg - OUH /ID# 161591
state: Syddanmark
city: Aalborg
country: Denmark
facility: Aalborg Universitets Hospital /ID# 160685
city: Odense C
country: Denmark
facility: Odense Universitets Hospital /ID# 155536
city: Al Sharqia
country: Egypt
facility: Zagazig University Hospitals /ID# 164018
city: Alexandria
country: Egypt
facility: Clinical Research Center, Faculty of Medicine, Alexandria university. /ID# 157876
city: Alexandria
country: Egypt
facility: Clinical Research Center, Faculty of Medicine, Alexandria university. /ID# 164423
city: Cairo
country: Egypt
facility: Clinical Research Center, Faculty of Medicine, Cairo university /ID# 157176
city: Cairo
country: Egypt
facility: National Hepatology and Tropical Medicine Research Institute /ID# 157875
city: Cairo
country: Egypt
facility: Internal Medicine Department, Faculty of Medicine, AinShams University /ID# 158630
city: Tallinn
country: Estonia
facility: East Tallinn Central Hospital /ID# 157072
state: Harjumaa
city: Tallinn
country: Estonia
facility: West Tallinn Central Hospital /ID# 157073
city: Nice
country: France
facility: Chu de Nice-Hopital L'Archet Ii /Id# 162545
state: Alpes-Maritimes
city: Pierre Benite CEDEX
country: France
facility: HCL - Hôpital Lyon Sud /ID# 162548
state: Auvergne-Rhone-Alpes
city: Pessac CEDEX
country: France
facility: CHU Bordeaux - Hopital Haut Lévêque /ID# 162546
state: Gironde
city: Lille
country: France
facility: CHRU Lille - Hopital Claude Huriez /ID# 162547
state: Hauts-de-France
city: Montpellier Cedex 5
country: France
facility: CHU Montpellier - Hôpital Saint Eloi /ID# 215146
state: Herault
city: Clichy
country: France
facility: Hapital Beaujon /ID# 166287
state: Ile-de-France
city: St. Priest En Jarez
country: France
facility: CHU de SAINT ETIENNE - Hopital Nord /ID# 162550
state: Loire
city: Vandœuvre-lès-Nancy
country: France
facility: CHRU Nancy - Hôpitaux de Brabois /ID# 162549
state: Meurthe-et-Moselle
city: Amiens CEDEX 1
country: France
facility: CHU Amiens-Picardie Site Sud /ID# 165056
state: Somme
city: La Tronche
country: France
facility: CHU Grenoble - Hopital Michallon /ID# 211980
city: Rennes
country: France
facility: Hospital Pontchaillou /ID# 213207
city: Heidelberg
country: Germany
facility: Praxis fuer Gastroenterologie /ID# 166148
state: Baden-Wuerttemberg
city: Mannheim
country: Germany
facility: Universitatsklinikum Mannheim /ID# 162026
state: Baden-Wuerttemberg
city: Tübingen
country: Germany
facility: Universitaetsklinikum Tuebingen /ID# 159341
state: Baden-Wuerttemberg
city: Ulm
country: Germany
facility: Universitaetsklinikum Ulm /ID# 164988
state: Baden-Wuerttemberg
city: Erlangen
country: Germany
facility: Universitaetsklinikum Erlangen /ID# 159332
state: Bayern
city: Frankfurt am Main
country: Germany
facility: Universitaetsklinikum Frankfurt /ID# 212977
state: Hessen
city: Cologne
country: Germany
facility: Evangelisches Krankenhaus Kalk /ID# 212724
state: Nordrhein-Westfalen
city: Grevenbroich
country: Germany
facility: Praxiszentrum fuer Gastroenterologie /ID# 211965
state: Nordrhein-Westfalen
city: Köln
country: Germany
facility: Universitaetsklinikum Koeln /ID# 164987
state: Nordrhein-Westfalen
city: Muenster
country: Germany
facility: Universitaetsklinikum Muenster /ID# 159333
state: Nordrhein-Westfalen
city: Saarbrücken
country: Germany
facility: Zentrum für Gastroenterologie Saar MVZ GmbH /ID# 210527
state: Saarland
city: Kiel
country: Germany
facility: Universitaetsklinikum Schleswig-Holstein Campus Kiel /ID# 159338
state: Schleswig-Holstein
city: Berlin-Zehlendorf
country: Germany
facility: Krankenhaus Waldfriede /ID# 212729
city: Berlin
country: Germany
facility: Charite Universitaetsmedizin Berlin - Campus Mitte /ID# 212218
city: Berlin
country: Germany
facility: Charite Universitaetsmedizin Berlin - Campus Mitte /ID# 212892
city: Berlin
country: Germany
facility: Gastroenterologische Spezialpraxis am Wittenbergplatz /ID# 211976
city: Berlin
country: Germany
facility: MVZ fuer Gastroenterlogie am Bayerischen Platz /ID# 159339
city: Berlin
country: Germany
facility: DRK Kliniken Berlin Westend /ID# 166149
city: Braunschweig
country: Germany
facility: Stadtisches Klinikum Braunschweig /ID# 163673
city: Dachau
country: Germany
facility: Medizinisches Versorgunszentrum Dachau /ID# 211550
city: Frankfurt am Main
country: Germany
facility: Agaplesion Markus Krankenhaus /ID# 159334
city: Freiburg
country: Germany
facility: Duplicate_Universitaetsklinikum Freiburg /ID# 162025
city: Hamburg
country: Germany
facility: Asklepios Westklinikum Hamburg /ID# 159336
city: Hannover
country: Germany
facility: Medizinische Hochschule Hannover /ID# 162027
city: Leipzig
country: Germany
facility: EUGASTRO GmbH /ID# 212077
city: Lueneburg
country: Germany
facility: Klinikum Lueneburg /ID# 163671
city: Magdeburg
country: Germany
facility: Universitaetsklinikum Magdeburg /ID# 211840
city: Minden
country: Germany
facility: Gastroenterologische Gemeinschaftspraxis Minden /ID# 162024
city: Regensburg
country: Germany
facility: Universitaetsklinikum Regensburg /ID# 163812
city: Wiesbaden
country: Germany
facility: Duplicate_Gastro-Praxis Wiesbaden /ID# 159335
city: Athens
country: Greece
facility: General Hospital of Chest Diseases of Athens SOTIRIA /ID# 170905
state: Attiki
city: Piraeus
country: Greece
facility: Tzaneio general hospital of Piraeus /ID# 206441
state: Attiki
city: Heraklion
country: Greece
facility: University General Hospital of Heraklion PA.G.N.I /ID# 157417
state: Kriti
city: Athens
country: Greece
facility: General Hospital of Athens Evaggelismos and Ophthalmiatrio of Athens Polyclinic /ID# 157418
city: Ioannina
country: Greece
facility: University General Hospital of Ioannina /ID# 157415
city: Pireaus
country: Greece
facility: General Hospital of Nikaia-Piraeus "Agios Panteleimon"- general hospital dytikis /ID# 157419
city: Thessaloniki
country: Greece
facility: Theageneio Anticancer Hospital /ID# 163922
city: Beaumont
country: Ireland
facility: Beaumont Hospital /ID# 157572
state: Dublin
city: Elm Park
country: Ireland
facility: St Vincent's University Hospital /ID# 157569
state: Dublin
city: Galway
country: Ireland
facility: University Hospital Galway /ID# 157570
city: Be'er Sheva
country: Israel
facility: Soroka University Medical Center /ID# 157789
state: HaDarom
city: Ramat Gan
country: Israel
facility: Sheba Medical Center /ID# 171059
state: Tel-Aviv
city: Tel Aviv-Yafo
country: Israel
facility: Tel Aviv Sourasky Medical Center /ID# 157787
state: Tel-Aviv
city: Haifa
country: Israel
facility: Duplicate_Rambam Medical Center /ID# 171056
city: Jerusalem
country: Israel
facility: Shaare Zedek Medical Center /ID# 163539
city: Jerusalem
country: Israel
facility: Shaare Zedek Medical Center /ID# 171055
city: Jerusalem
country: Israel
facility: Hadassah Medical Center-Hebrew University /ID# 171062
city: Torrette
country: Italy
facility: Duplicate_AOU Ospendali Riuniti di Ancona /ID# 162431
state: Ancona
city: Catanzaro
country: Italy
facility: Duplicate_Universita di Catanzaro Magna Graecia /ID# 212017
state: Calabria
city: Modena
country: Italy
facility: Duplicate_Azienda Ospedaliero-Universitaria Policlinico di Modena /ID# 212018
state: Emilia-Romagna
city: Rome
country: Italy
facility: Duplicate_Policlinico Universitario Campus Bio-Medico /ID# 162433
state: Lazio
city: Rome
country: Italy
facility: Azienda Ospedaliera San Camillo Forlanini /ID# 155660
state: Lazio
city: Rome
country: Italy
facility: Azienda Ospedaliero-Universitaria Policlinico Umberto I /ID# 166910
state: Lazio
city: Genoa
country: Italy
facility: Duplicate_Ospedale Policlinico San Martino/ Università Degli Studi Di Genova /ID# 162434
state: Liguria
city: Rho
country: Italy
facility: ASST Rhodense/Presidio Ospedaliero di Rho /ID# 211453
state: Milano
city: Rozzano
country: Italy
facility: Istituto Clinico Humanitas /ID# 155658
state: Milano
city: Rome
country: Italy
facility: Fondazione PTV Policlinico Tor Vergata /ID# 158023
state: Roma
city: Rome
country: Italy
facility: Presidio Columbus-Fondazione Policlinico Universitario Agostino Gemelli IRCCS-Un /ID# 155656
state: Roma
city: Florence
country: Italy
facility: Duplicate_Azienda Ospedaliera Univ. Meyer /ID# 168049
state: Toscana
city: Negrar
country: Italy
facility: IRCCS Ospedale Sacro Cuore Don Calabria /ID# 161302
state: Verona
city: Bologna
country: Italy
facility: A.O.U. di Bologna Policlinico S.Orsola-Malpighi /ID# 155659
city: Catania
country: Italy
facility: A.O. Per L'Emergenza Cannizzaro /ID# 161303
city: Milano
country: Italy
facility: ASST Fatebenefratelli Sacco-Ospedale Sacco /ID# 155655
city: Milan
country: Italy
facility: Fondazione IRCCS Ca Granda Ospedale Maggiore Policlinico /ID# 155657
city: Pavia
country: Italy
facility: Duplicate_Fondazione IRCCS Policlinico S. Matteo /ID# 212030
city: Guri
country: Korea, Republic of
facility: Hanyang University Guri Hospital /ID# 163351
state: Gyeonggido
city: Seongnam si
country: Korea, Republic of
facility: CHA Bundang Medical center CHA University /ID# 163377
state: Gyeonggido
city: Suwon
country: Korea, Republic of
facility: The Catholic University of Korea, ST. Vincent's Hospital /ID# 163365
state: Gyeonggido
city: Seoul
country: Korea, Republic of
facility: Kangbuk Samsung Hospital /ID# 163354
state: Seoul Teugbyeolsi
city: Seoul
country: Korea, Republic of
facility: Severance Hospital /ID# 163374
state: Seoul Teugbyeolsi
city: Busan
country: Korea, Republic of
facility: Inje University Haeundae Hospital /ID# 202516
city: Busan
country: Korea, Republic of
facility: Duplicate_Dong-A University Hospital /ID# 163370
city: Busan
country: Korea, Republic of
facility: Pusan National University Hospital /ID# 163376
city: Daegu
country: Korea, Republic of
facility: Yeungnam University Medical Center /ID# 163366
city: Daejeon
country: Korea, Republic of
facility: The Catholic University of Korea, Daejeon St.Mary's Hospital /ID# 213553
city: Seoul
country: Korea, Republic of
facility: Samsung Medical Center /ID# 163426
city: Riga
country: Latvia
facility: Pauls Stradins Clinical University Hospital /ID# 159616
city: Riga
country: Latvia
facility: Riga East Clinical University Hospital /ID# 159615
city: Kaunas
country: Lithuania
facility: Hospital of Lithuanian University of Health Sciences Kaunas Clinics /ID# 162584
city: Vilnius
country: Lithuania
facility: Vinius University Hospital Santaros Klinikos /ID# 162524
city: Division Pantai Barat Utara
country: Malaysia
facility: Queen Elizabeth Hospital /ID# 160659
state: Sabah
city: Kuala Lumpur
country: Malaysia
facility: Universiti Kebangsaan Malaysia (UKM) Medical Centre /ID# 201362
state: Selangor
city: Kelantan
country: Malaysia
facility: Universiti Sains Malaysia /ID# 160661
city: Zapopan
country: Mexico
facility: Investigacion Biomedica para el Desarrollo de Farmacos, S.A. de C.V. /ID# 170766
state: Jalisco
city: Cuernavaca
country: Mexico
facility: JM Research SC /ID# 170762
state: Morelos
city: Merida
country: Mexico
facility: Unidad de Atencion Medica e Investigacion en Salud /ID# 170765
state: Yucatan
city: Del. Benito Juárez
country: Mexico
facility: Health Pharma Professional Research S.A de C.V /ID# 170763
city: Amsterdam
country: Netherlands
facility: Academisch Medisch Centrum /ID# 157953
city: Tilburg
country: Netherlands
facility: Elisabeth Tweesteden Ziekenhuis /ID# 163620
city: Christchurch
country: New Zealand
facility: Christchurch Hospital /ID# 167212
state: Canterbury
city: Dunedin
country: New Zealand
facility: Dunedin Hospital /ID# 167215
state: Otago
city: Auckland
country: New Zealand
facility: Middlemore Clinical Trials /ID# 167214
city: Wellington
country: New Zealand
facility: Duplicate_Wellington Hospital (Capital and Coast District Health Board) /ID# 167213
city: Wroclaw
country: Poland
facility: Planetmed Sp. z o.o. /ID# 205159
state: Dolnoslaskie
city: Lodz
country: Poland
facility: Uniwersytecki Szpital Kliniczny nr 1 im. Norberta Barlickiego w Lodzi /ID# 212290
state: Lodzkie
city: Lublin
country: Poland
facility: 1 Wojskowy Szpital Kliniczny Z Poliklinika /Id# 209984
state: Lubelskie
city: Lublin
country: Poland
facility: Samodzielny Publiczny Szpital Kliniczny Nr 4 w Lublinie /ID# 209980
state: Lubelskie
city: Warszawa
country: Poland
facility: Centrum Zdrowia MDM /ID# 163602
state: Mazowieckie
city: Warszawa
country: Poland
facility: Centralny Szpital Kliniczny MSWiA w Warszawie /ID# 163604
state: Mazowieckie
city: Warszawa
country: Poland
facility: Instytut Pomnik - Centrum Zdrowia Dziecka /ID# 213578
state: Mazowieckie
city: Rzeszów
country: Poland
facility: Centrum Medyczne Medyk /ID# 212888
state: Podkarpackie
city: Chojnice
country: Poland
facility: Centrum Medyczne LukaMed Joanna Luka-Wendrowska /ID# 212079
state: Pomorskie
city: Tychy
country: Poland
facility: H-T. Centrum Medyczne - Endoterapia /ID# 212458
state: Slaskie
city: Olsztyn
country: Poland
facility: Wojewodzki Szpital Specjalistyczny /ID# 212400
state: Warminsko-mazurskie
city: Warsaw
country: Poland
facility: Duplicate_Niepubliczny Zakład Opieki Zdrowotnej VIVAMED Jadwiga Miecz /ID# 202434
city: Wroclaw
country: Poland
facility: Uniwersytecki Szpital Kliniczny im. Jana Mikulicza-Radeckiego we Wroclaw /ID# 212534
city: Guimaraes
country: Portugal
facility: Hospital da Senhora da Oliveira Guimaraes, EPE /ID# 160691
state: Braga
city: Portimão
country: Portugal
facility: Centro Hospitalar Universitário do Algarve, EPE - Hospital de Portimão /ID# 167754
state: Faro
city: Santa Maria Da Feira
country: Portugal
facility: Centro Hospitalar de Entre Douro e Vouga /ID# 160676
state: Porto
city: Almada
country: Portugal
facility: Hospital Garcia de Orta, EPE /ID# 160688
city: Faro
country: Portugal
facility: Centro Hospitalar Universitário do Algarve, EPE - Hospital Faro /ID# 160732
city: Lisboa
country: Portugal
facility: Centro Hospitalar Universitario Lisboa Central, EPE - Hospital dos Capuchos /ID# 160677
city: Lisboa
country: Portugal
facility: Centro Hospitalar de Lisboa Ocidental, EPE - Hospital Egas Moniz /ID# 167753
city: Lisboa
country: Portugal
facility: Centro Hospitalar Universitário de Lisboa Norte, EPE - Hospital de Santa Maria /ID# 160741
city: Loures
country: Portugal
facility: Hospital Beatriz Ângelo /ID# 207758
city: Porto
country: Portugal
facility: Centro Hospitalar Universitario de Sao Joao, EPE /ID# 160742
city: Viseu
country: Portugal
facility: Centro Hosp de Tondela-Viseu /ID# 160731
city: Sector 2
country: Romania
facility: Institutul Clinic Fundeni /ID# 170890
state: Bucuresti
city: Bucharest
country: Romania
facility: Duplicate_Institutul Clinic Fundeni /ID# 170888
city: Cluj
country: Romania
facility: Tvm Med Serv Srl /Id# 170891
city: Timisoara
country: Romania
facility: Duplicate_Centrul Medical Tuculanu SRL /ID# 170892
city: Timișoara
country: Romania
facility: Cabinet Particular Policlinic Algomed /ID# 170889
city: Kemerovo
country: Russian Federation
facility: Kuzbass Regional Clinical Hospital /ID# 200707
state: Kemerovskaya Oblast
city: Perm
country: Russian Federation
facility: Duplicate_Perm state medical university n.a. E.A. Vagner /ID# 207438
state: Permskiy Kray
city: Stavropol
country: Russian Federation
facility: Professor Pasechnikov Gastroenterology and Pankreatology clinic /ID# 200701
state: Stavropol Skiy Kray
city: Tver
country: Russian Federation
facility: Tver Regional Clinical Hospital /ID# 206586
state: Tverskaya Oblast
city: Tyumen
country: Russian Federation
facility: Regional Clinical Hospital #1 /ID# 200708
state: Tyumenskaya Oblast
city: Izhevsk
country: Russian Federation
facility: Alliance Biomedical Ural Group /ID# 200703
state: Udmurtskaya Respublika
city: Moscow
country: Russian Federation
facility: National Medical Research Center of Coloproctology n.a. A. N. Ryzhikh /ID# 204806
city: St. Petersburg
country: Russian Federation
facility: City Clinical Hospital No. 31 /ID# 208865
city: Ulyanovsk
country: Russian Federation
facility: Ulyanovsk Regional Clinical Hospital /ID# 200700
city: Belgrade
country: Serbia
facility: Clinical Hosp Center Zvezdara /ID# 156956
state: Beograd
city: Belgrade
country: Serbia
facility: Military Medical Academy /ID# 156963
state: Beograd
city: Belgrade
country: Serbia
facility: University Clinical Center Serbia /ID# 156957
state: Beograd
city: Belgrade
country: Serbia
facility: Duplicate_Clin Hosp Ctr Bezanijska Kosa /ID# 156959
state: Beograd
city: Kragujevac
country: Serbia
facility: University Clinical Center Kragujevac /ID# 156961
state: Sumadijski Okrug
city: Novi Sad
country: Serbia
facility: Clinical Center Vojvodina /ID# 156958
state: Vojvodina
city: Belgrade
country: Serbia
facility: University Children's Hospital 'Tirsova' /ID# 211480
city: Belgrade
country: Serbia
facility: Clinical Hospital Center Dr Dragisa Misovic - Dedinje /ID# 212798
city: Singapore
country: Singapore
facility: National University Hospital /ID# 160662
city: Singapore
country: Singapore
facility: Singapore General Hospital /ID# 160663
city: Singapore
country: Singapore
facility: KL Ling Gastroenterology and Liver Clinic /ID# 205736
city: Banska Bystrica
country: Slovakia
facility: Fakultna nemocnica s poliklinikou F.D. Roosevelta Banska Bystrica /ID# 156453
city: Martin
country: Slovakia
facility: Univerzitna nemocnica Martin /ID# 163205
city: Nitra
country: Slovakia
facility: KM Management, spol. s.r.o. /ID# 206762
city: Presov
country: Slovakia
facility: GASTRO I., s.r.o. /ID# 156455
city: Johannesburg
country: South Africa
facility: Wits Clinical Research Site /ID# 171169
state: Gauteng
city: CAPE TOWN Milnerton
country: South Africa
facility: Spoke Research Inc /ID# 171172
state: Western Cape
city: Cape Town
country: South Africa
facility: Kingsbury Hospital /ID# 171158
state: Western Cape
city: Cape Town
country: South Africa
facility: Private Practice Dr MN Rajabally /ID# 171159
state: Western Cape
city: Ferrol
country: Spain
facility: Hospital Arquitecto Marcide - Complejo Hospitalario Universitario de Ferrol /ID# 157534
state: A Coruna
city: Sabadell
country: Spain
facility: Consorci Corporacio Sanitaria Parc Tauli Sabadell /ID# 159234
state: Barcelona
city: Bilbao
country: Spain
facility: Hospital Universitario Basurto /ID# 205188
state: Vizcaya
city: Barcelona
country: Spain
facility: Hospital Clinic de Barcelona /ID# 157533
city: Madrid
country: Spain
facility: Hospital General Universitario Gregorio Maranon /ID# 161144
city: Madrid
country: Spain
facility: Hospital Universitario La Paz /ID# 159232
city: Salamanca
country: Spain
facility: Hospital Clinico Universitario de Salamanca /ID# 157539
city: Sevilla
country: Spain
facility: Hospital Universitario Virgen Macarena /ID# 159966
city: Valencia
country: Spain
facility: Hospital Clinico Universitario de Valencia /ID# 209699
city: Valencia
country: Spain
facility: Hospital Universitario y Politecnico La Fe /ID# 157537
city: Zaragoza
country: Spain
facility: Hospital Universitario Miguel Servet /ID# 157538
city: Basel
country: Switzerland
facility: Universitätsspital Basel /ID# 166321
state: Basel-Stadt
city: Zürich
country: Switzerland
facility: Universitätsspital Zürich /ID# 163528
state: Zuerich
city: Taichung City
country: Taiwan
facility: China Medical University Hosp /ID# 160130
city: Taichung
country: Taiwan
facility: Taichung Veterans General Hosp /ID# 160134
city: Tainan City
country: Taiwan
facility: National Cheng Kung University Hospital /ID# 160129
city: Taipei City
country: Taiwan
facility: National Taiwan University Hospital /ID# 162189
city: Taipei City
country: Taiwan
facility: Taipei Veterans General Hosp /ID# 212711
city: Uzhhorod
country: Ukraine
facility: Duplicate_Transcarpathian Regional Clin. /ID# 167958
city: Київ
country: Ukraine
facility: Kyiv Municipal Clinical Hospital #18 /ID# 162527
city: Glasgow
country: United Kingdom
facility: NHS Greater Glasgow and Clyde /ID# 202314
state: Scotland
city: Chertsey
country: United Kingdom
facility: Ashford and St Peter's Hospitals NHS Foundation Trust /ID# 207938
state: Surrey
city: Barnsley
country: United Kingdom
facility: Barnsley Hospital NHS Foundation Trust /ID# 202772
city: Birmingham
country: United Kingdom
facility: University Hospitals Birmingham NHS Foundation Trust /ID# 157577
city: Cambridge
country: United Kingdom
facility: Cambridge University Hospitals NHS Foundation Trust /ID# 158037
city: Edinburgh
country: United Kingdom
facility: NHS Lothian /ID# 207446
city: Hull
country: United Kingdom
facility: Hull University Teaching Hospitals NHS Trust /ID# 158759
city: London
country: United Kingdom
facility: King's College Hospital NHS Foundation Trusts /ID# 158758
city: Newcastle Upon Tyne
country: United Kingdom
facility: The Newcastle Upon Tyne Hospitals NHS Foundation Trust /ID# 163889
city: Oxford
country: United Kingdom
facility: Oxford University Hospitals NHS Foundation Trust /ID# 158039
city: Salford
country: United Kingdom
facility: Duplicate_Northern Care Alliance NHS Group /ID# 207765
Study officials:
affiliation: AbbVie
name: ABBVIE INC.
role: STUDY_DIRECTOR
References:
citation: D'Haens G, Panaccione R, Baert F, Bossuyt P, Colombel JF, Danese S, Dubinsky M, Feagan BG, Hisamatsu T, Lim A, Lindsay JO, Loftus EV Jr, Panes J, Peyrin-Biroulet L, Ran Z, Rubin DT, Sandborn WJ, Schreiber S, Neimark E, Song A, Kligys K, Pang Y, Pivorunas V, Berg S, Duan WR, Huang B, Kalabic J, Liao X, Robinson A, Wallace K, Ferrante M. Risankizumab as induction therapy for Crohn's disease: results from the phase 3 ADVANCE and MOTIVATE induction trials. Lancet. 2022 May 28;399(10340):2015-2030. doi: 10.1016/S0140-6736(22)00467-6.