Clinical trial NCT06183177: Pain Function and QOL Undergoing Whole-Body Vibration and Exercise in End-Stage Knee Osteoarthritis
Official title: Improving Pain, Function and Quality of Life in End-Stage Knee Osteoarthritis: A Prospective Cohort Study of Whole-Body Vibration and Exercise as Bridging Therapies for Total Knee Replacement
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Knee Osteoarthritis
Pain, Joint
Lead sponsor: Chinese University of Hong Kong
Sponsor class: OTHER
First posted: 2023-12-27
Enrollment: 517
Sex: ALL
Minimum age (years): 60
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NON_RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: Knee osteoarthritis (KOA) is a chronic progressive disease that imparts substantial socioeconomic burden to society and healthcare systems. The prevalence of KOA has dramatically risen in recent decades due to consistent increases in life expectancy, and demand for joint replacement continues to rise. Total knee replacement is indicated for end-stage KOA, as it is very effective in terms of pain relief, improvement of function, and quality of life. However, the investigators will be facing an unsustainable joint replacement burden, with significant healthcare budget and health workforce implications. To alleviate this problem, different strategies including reinforce the importance of education and exercise are included; as previous studies showed that less than 40% of patients with KOA received non-pharmacological treatment, indicating that the uptake of evidence-based guidelines in clinical practice and rehabilitation is still suboptimal. Several literatures revealed that quadriceps and hamstrings strength exercise could effectively reduce pain. It has widely accepted that patients with end stage KOA will eventually pursue total knee replacement as the only viable option, and exercise has low efficacy in reduction of pain and disability in this group of patients. So, the investigators would like to know whether exercise therapy can help severe KOA patients


Eligibility criteria: Inclusion Criteria:

* Patients with end-stage knee osteoarthritis on queue for scheduling primary total knee replacement
* Completed 8-week course of physiotherapy program

Exclusion Criteria:

* TKR during the last 12 months
* Severe heart failure or neurological diseases affecting physical functions

Primary outcomes:
measure: Numerical pain rating scale
timeFrame: Baseline, 8 weeks
measure: Range of motion (ROM) of the diseased knee
timeFrame: Baseline, 8 weeks
measure: Gait analysis
timeFrame: Baseline, 8 weeks
measure: Knee Society Score
timeFrame: Baseline, 8 weeks
measure: Knee Society Functional Assessment
timeFrame: Baseline, 8 weeks
Secondary outcomes:
measure: Knee injury and Osteoarthritis Outcome Score (KOOS)-Knee pain (KP)
timeFrame: Baseline, 8 weeks
measure: Knee injury and Osteoarthritis Outcome Score (KOOS)-Other Symptoms (S)
timeFrame: Baseline, 8 weeks
measure: Knee injury and Osteoarthritis Outcome Score (KOOS)- Activities of Daily Living (ADL)
timeFrame: Baseline, 8 weeks
measure: Knee injury and Osteoarthritis Outcome Score (KOOS)-Sport and Recreation function
timeFrame: Baseline, 8 weeks
measure: Knee injury and Osteoarthritis Outcome Score (KOOS)-knee-related Quality of Life (QOL)
timeFrame: Baseline, 8 weeks
measure: Timed Up and Go test
timeFrame: Baseline, 8 weeks
measure: 30-sec chair stand test
timeFrame: Baseline, 8 weeks
measure: Functional reach test
timeFrame: Baseline, 8 weeks
Other outcomes:
Locations:
city: Hong Kong
country: Hong Kong
facility: Michael.Ong@Cuhk.Edu.Hk
state: NEW Territories
Study officials:
References: