Clinical trial NCT01839006: Clinical Significance of Supranormal Differential Renal Function in the Recovery of Hydronephrosis
Official title: Clinical Significance of Supranormal Differential Renal Function in the Recovery of Unilateral Hydronephrosis After Surgery: Long-term Results
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Hydronephrosis
Keywords: hydronephrosis
ultrasonography
Kidney Function Test
Patients with unilateral UPJO and patients with preop HN in USG and supranormal renal function in DTPA renography
Lead sponsor: Seoul National University Hospital
Sponsor class: OTHER
First posted: 2013-04-24
Enrollment: 34
Sex: ALL
Maximum age (years): 18
Standard ages: CHILD
ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: RETROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: patients with unilateral UPJO pediatric patients who underwent dismembered pyeloplasty and preoperative HN in USG and supranormal renal function in DTPA renography

Brief summary: The purpose of this study is to assess the clinical significance of supranormal differential renal function (DRF) in the recovery of unilateral hydronephrosis (HN) after surgery, pediatric patients who underwent pyeloplasty for ureteropelvic junction obstruction (UPJO) who showed supranormal DRF (\> 55%) in the DTPA renography will be analyzed.

Detailed description: To assess the clinical significance of supranormal differential renal function (DRF) in the recovery of unilateral hydronephrosis (HN) after surgery, pediatric patients who underwent pyeloplasty for ureteropelvic junction obstruction (UPJO) who showed supranormal DRF (\> 55%) in the DTPA renography will be analyzed. Clinical parameters including age at the first visit, age at operation, gender, laterality, and follow-up period will be evaluated. To evaluate predictors of recovery from supranormal renal function according to the level of DRF, univariate and multivariate logistic regression analyses will be performed. Patients would be subcategorized into two groups; group A (DRF ≤60%) and group B (DRF \>60%) in consideration of the mean value of preoperative DRF and each parameter of group A was compared to that of group B using independent sample's t test and chi square test. Kaplan-Meier analysis and log-rank test will be used to determine the difference of recovery time of obstructed hydronephrosis in each parameter.

Eligibility criteria: Inclusion Criteria:

* ureteropelvic junction obstruction
* hydronephrosis
* differential renal function more than 55% in DTPA
* follow-up period more than 1 year

Exclusion Criteria:

* urological anomalies, such as vesicoureteral reflux, ureterocele, cystic kidney disease, posterior urethral valves, duplex anomalies, neurogenic bladder, and solitary kidney or patients who underwent any previous urological surgery

Primary outcomes:
measure: Hydronephrosis
timeFrame: postop 6 months
Secondary outcomes:
measure: renal parenchymal thickness
timeFrame: postop 6 months
Other outcomes:
Locations:
city: Seoul
country: Korea, Republic of
facility: Seoul National University Hospital
Study officials:
affiliation: Seoul National Universitiy Hospital
name: Sung Yong Cho, M.D.
role: PRINCIPAL_INVESTIGATOR
References: