Clinical trial NCT01221077: Study of Erlotinib (Tarceva®) in Combination With OSI-906 in Patients With Advanced Non-small Cell Lung Cancer (NSCLC) With Activating Mutations of the Epidermal Growth Factor Receptor (EGFR) Gene
Official title: A Randomized, Double-Blind, Phase 2 Study of Erlotinib (Tarceva®) in Combination With OSI-906 or Placebo in Chemonaive Patients With Advanced NSCLC With Activating Mutations of the Epidermal Growth Factor Receptor (EGFR) Gene
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE2
Conditions: NSCLC
Non Small Cell Lung Cancer
Keywords: NSCLC
Epidermal Growth Factor Receptor
EGFR
Non-small cell lung cancer
Tarceva
Activating mutations
OSI-906
Chemonaive
IGF-IR
Erlotinib
Lead sponsor: Astellas Pharma Inc
Sponsor class: INDUSTRY
First posted: 2010-10-14
Enrollment: 88
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: A multicenter, randomized, double-blind, placebo-controlled, phase 2 study of Erlotinib (Tarceva®) in combination with OSI-906 in Patients with Advanced non-small cell lung cancer (NSCLC) with Activating Mutations of the Epidermal Growth Factor Receptor (EGFR) Gene who are Chemonaive.

Detailed description: Based on the recommendation of the Data Monitoring Committee, OSI-906 and matching placebo are no longer being administered as of 01 March 2013.

This is a multi-center, randomized (1:1), double-blind, placebo-controlled, phase 2 study. Patients will be stratified according to the following 2 parameters: (1) EGFR activating mutation type (exon 19 deletion versus exon 21 single point mutation); and (2) Eastern Cooperative Oncology Group (ECOG) performance status (0 vs. 1).

Eligibility criteria: Inclusion Criteria:

* Historically confirmed advanced NSCLC stages IIIB or IV
* Exon 19 deletion or exon 21 activating mutation in EGFR
* EGFR mutation status must be confirmed for participation in the study. EGFR can be performed either by central or local laboratory. If analysis is done locally, verifiable documentation confirming the EGFR mutation status must be submitted for review and approval by sponsor prior to randomization. If no local result is available, formalin-fixed, paraffin-embedded archival tissue representative of the tumor or, in the absence of archival tissue, a fresh tumor tissue sample of sufficient size to perform EGFR mutation analysis must be submitted centrally. Results of the central analysis must be available prior to randomization. Additionally, subjects should provide tissue blocks for biomarker central analysis whenever possible. Ideal tissue requirement: block with ≥5 mm2 tumor area sufficient to provide four 4-micron, and five 10-micron sections
* Measurable disease according to RECIST (version 1.1)
* ECOG performance status 0-1
* Must be able to take oral medication
* Fasting glucose \<= 150 mg/dL (8.3 mmol/L). Concurrent use of non-insulinotropic anti hyperglycemic therapy is permitted if the dose has been stable for \>= 4 weeks at the time of randomization
* Adequate hematopoietic, hepatic, and renal function as follows:

  * Neutrophil count \>= 1500/uL
  * Platelet count \>= 100,000/uL
  * Serum creatinine \<= 1.5 x Upper Limit of Normal (ULN)
  * Potassium, magnesium, and calcium within normal limits (supplementation and re-testing is permitted)
  * Total bilirubin \<= 1.5 x ULN
  * AST and ALT \<= 2.5 x ULN, or \<= 5 x ULN if patient has documented liver metastases
* Female subject must be either:

  * Of non child bearing potential:

    1. post-menopausal (defined as at least 1 year without any menses) prior to Screening, or
    2. documented surgically sterile or status post hysterectomy (at least 1 month prior to Screening).
  * Or, if of childbearing potential:

    1. must have a negative urine pregnancy test at Screening, and
    2. must use two forms of birth control (at least one of which must be a barrier method) starting at Screening and throughout the study period and for 30 days after final study drug administration. Acceptable forms include:

       1. Established use of oral, injected or implanted hormonal methods of contraception;
       2. Placement of an intrauterine device (IUD) or intrauterine system (IUS);
       3. Barrier methods of contraception: Condom OR Occlusive cap (diaphragm or cervical/vault caps) with spermicidal foam/gel/film/cream/suppository.
* Female subject must not be breastfeeding at Screening or during the study period and for 30 days after final study drug administration.
* Female subject must not donate ova starting at Screening and throughout the study period and for 30 days after final study drug administration.
* Male subject and their female spouse/partners who are of childbearing potential must be using highly effective contraception consisting of two forms of birth control (one of which must be a barrier method) starting at Screening and continue throughout the study period and for 30 days after final study drug administration. Acceptable forms include:

  1. Established use of oral, injected or implanted hormonal methods of contraception.
  2. Placement of an intrauterine device (IUD) or intrauterine system (IUS).
  3. Barrier methods of contraception: Condom OR Occlusive cap (diaphragm or cervical/vault caps) with spermicidal foam/gel/film/cream/suppository.
* Male subjects must not donate sperm starting at Screening and throughout the study period and for at least 30 days after final study drug administration.
* Patients must provide written informed consent to participate in the study
* Patients may not have received chemotherapy for advanced NSCLC. Previous adjuvant and/or neoadjuvant treatment for NSCLC is permitted
* Prior radiation therapy is permitted provided patients have recovered from the acute, toxic effects of radiotherapy prior to randomization. A minimum of 28 days must have elapsed between the end of radiotherapy and randomization
* Prior surgery is permitted provided that the surgery was done \>= 28 days prior to randomization and adequate wound healing has occurred prior to randomization

Exclusion Criteria:

* Prior exposure to agents directed at the Human Epidermal Receptor (HER) axis (eg, erlotinib, gefitinib, and cetuximab)
* Prior insulin-like growth factor -1 receptor (IGF-1R) inhibitor therapy
* Malignancies other than NSCLC within the past 3 years (exceptions if curatively treated; basal or squamous cell carcinoma of skin; locally advanced prostate cancer; ductal carcinoma in situ of breast; in situ cervical carcinoma; and superficial bladder cancer)
* Diabetes mellitus currently requiring insulinotropic or insulin therapy
* Use of proton pump inhibitors such as omeprazole within 14 days prior to randomization. H2-receptor antagonists such as ranitidine are not excluded
* Symptomatic brain metastases that are not stable, require steroids, or have required radiation and/or other related treatment (i.e., anti-epileptic medication) within 21 days prior to randomization
* Participated in any interventional clinical study or has been treated with any investigational drugs within 30 days or 5 half lives whichever is longer, prior to the initiation of Screening or during the course of the study.
* History of poorly controlled gastrointestinal disorders that could affect the absorption of study drug (eg, Crohn's disease or ulcerative colitis)
* History (within last 6 months) of significant cardiovascular disease unless the disease is well-controlled. Significant cardiac disease includes second/third degree heart block; clinically significant ischemic heart disease; superior vena cava (SVC) syndrome; poorly controlled hypertension; congestive heart failure of New York Heart Association (NYHA) Class II or worse (slight limitation of physical activity; comfortable at rest, but no ordinary physical activity results in fatigue, palpitation, or dyspnea)
* History of arrhythmia (multifocal premature ventricular contractions \[PVCs\], bigeminy, trigeminy, ventricular tachycardia, or uncontrolled atrial fibrillation) that is symptomatic or requires treatment (\>= grade 3), left bundle branch block (LBBB), or asymptomatic sustained ventricular tachycardia are not allowed. Patients with atrial fibrillation controlled by medication are not excluded
* Mean QTcF interval \>= 450 msec at screening
* Use of drugs that have a known risk of causing Torsades de Pointes (TdP) ('Torsades List' on www.azcert.org/medical-pros/drug-lists/bycategory.cfm) are prohibited within 14 days prior to randomization
* Use of strong/moderate CYP1A2 inhibitors such as ciprofloxacin and fluvoxamine. Other less potent CYP1A2 inhibitors/inducers are not excluded
* Use of strong/moderate CYP3A4 inhibitors and inducers
* History of cerebrovascular accident (CVA) within 6 months prior to randomization or that resulted in ongoing neurologic instability
* History of any psychiatric or neurologic condition that might impair the patient's ability to understand or to comply with the requirements of the study or to provide informed consent
* Pregnant or breast-feeding females
* History of allergic reactions attributed to compounds of similar chemical or biologic composition to the study drug
* Active infection, serious underlying medical condition (including any type of active seizure disorder within 12 months prior to randomization), symptomatic brain metastases, or serious chronic illness that would impair the ability of the patient to receive study drug

Primary outcomes:
measure: Progression-free survival of OSI-906 in combination with Erlotinib or Erlotinib plus placebo
timeFrame: 15 months
Secondary outcomes:
measure: Overall Survival (OS)
timeFrame: 33 months
measure: Disease Control Rate (DCR)
timeFrame: 33 months
measure: Best Overall Response Rate
timeFrame: 33 months
measure: Duration of Response (CR/PR)
timeFrame: 33 months
measure: Safety assessed through evaluation of adverse events, laboratory, physical examination, and Electrocardiogram (ECG) data
timeFrame: 33 months
Other outcomes:
Locations:
city: La Jolla
country: United States
facility: University of California, San Diego/Moores Cancer Center
state: California
city: Tampa
country: United States
facility: H. Lee Moffitt Cancer Center and Research Institute
state: Florida
city: Weston
country: United States
facility: Cleveland Clinic Florida
state: Florida
city: Chicago
country: United States
facility: Northwestern Memorial Hospital
state: Illinois
city: Chicago
country: United States
facility: Rush University Medical Center
state: Illinois
city: Baltimore
country: United States
facility: Johns Hopkins Sidney Kimmel Comprehensive Cancer Center
state: Maryland
city: Detroit
country: United States
facility: Karmanos Cancer Institute
state: Michigan
city: New York
country: United States
facility: Memorial Sloan Kettering Cancer Center
state: New York
city: Charleston
country: United States
facility: Medical University of South Carolina
state: South Carolina
city: Memphis
country: United States
facility: University of Tennessee Cancer Institute
state: Tennessee
city: Nashville
country: United States
facility: Vanderbilt University Medical Center
state: Tennessee
city: Seattle
country: United States
facility: Swedish Cancer Institute
state: Washington
city: Seattle
country: United States
facility: Seattle Cancer Care Alliance University of Washington
state: Washington
city: Hamilton
country: Canada
facility: Juravinski Cancer Centre
state: Ontario
city: London
country: Canada
facility: London Regional Cancer Program
state: Ontario
city: Toronto
country: Canada
facility: Princess Margaret Hospital
state: Ontario
city: Montreal
country: Canada
facility: Jewish General Hospital
state: Quebec
city: Chai Wan
country: Hong Kong
facility: Pamela Youde Nethersole Eastern Hospital
city: Ilsimri
country: Korea, Republic of
facility: Chonnam National University Hwasun Hospital
state: Hwasun-gun
city: Songpa-gu
country: Korea, Republic of
facility: Asan Medical Center
state: Seoul
city: Seongnam-si
country: Korea, Republic of
facility: Seoul National University Bundang Hospital
city: Seoul
country: Korea, Republic of
facility: Samsung Medical Center
city: Seoul
country: Korea, Republic of
facility: Korea University Anam Hospital
city: Singapore
country: Singapore
facility: Oncocare Cancer Center
city: Singapore
country: Singapore
facility: Johns Hopkins Singapore International Medical Centre
city: Phayathai
country: Thailand
facility: National Cancer Institute
state: Bangkok
city: Chiang Mai
country: Thailand
facility: Maharaj Nakorn Chiangmai
city: Khon Kaen
country: Thailand
facility: Khon Kaen University
city: Songkla
country: Thailand
facility: Songklanagarind Hospital, Prince of Songkla University
Study officials:
affiliation: Astellas Pharma Global Development
name: Medical Director
role: STUDY_DIRECTOR
References: