Clinical trial NCT04235153: CAncer, NUtrition and Taste - Validation of the CANUT-QVA Questionnaire on Eating Habits in Cancer Patients
Official title: CAncer, NUtrition and Taste - Validation of the CANUT-QVA Questionnaire on Eating Habits in Cancer Patients
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Hematologic Cancer
Undernutrition
Chemotherapy Effect
Taste Disorders
Chemotherapy-Induced Change
Olfactory Disorder
Lead sponsor: Hospices Civils de Lyon
Sponsor class: OTHER
First posted: 2020-01-21
Enrollment: 127
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Patients with solid or hematological cancer complete the CANUT-QVA questionnaire.

Brief summary: Cancer patients are at high risk of undernutrition, which is generally more pronounced for solid tumours (upper digestive tract, Ear Nose and Throat (ENT), bronchial tubes). This undernutrition leads to major weight loss and cachexia, and may represent the first sign of a call for a diagnosis of cancer. Cancer-related undernutrition is multi-factorial origins and has multiple consequences.

Chemotherapy treatments can induce various adverse effects in patients, including sensory disturbances at the beginning of treatment in addition to disturbances that may already be present before any treatment. The alteration of taste and odour, observed in 86% of patients, can induce a change in food preferences, promote the development of aversions, and therefore, lead to a significant reduction in the pleasure of eating. Loss of appetite, decreased food intake and the development of aversions to certain foods are situations experienced by a large proportion of patients treated with chemotherapy.

The assessment of taste disorders in patients treated with chemotherapy is established through the use of questionnaires, interviews and taste tests.

Changes in the perception and identification of salty, sweet, bitter and sour flavours are common in patients treated with chemotherapy.

As regards food products, patients report developing olfactory hypersensitivity mainly for food of animal origin, in particular for odours of fish, frying, cheese and eggs.

The CANUT project aims to study the effect of pathology and chemotherapy on gustatory and olfactory mechanisms, and in particular on interindividual differences in the perception and appreciation of food.

In order to monitor the evolution of patients' eating habits over time, the diet-related quality of life questionnaire (CANUT-QVA) was constructed from items selected from the Well-being related to Food questionnaire (WELLBFQ) after eliminating questions that were too general or expressed in terms of importance to use perception-related responses as a priority.

After this part, an evaluation of the 9 dimensions of the CANUT-QVA questionnaire will be performed.


Eligibility criteria: Inclusion Criteria:

* Patient with solid or hematological cancer (any stage of disease and any treatment) diagnosed within 12 months of inclusion.
* Patient who does not object to participate in the trial
* Patient affiliated to a social security system

Exclusion Criteria:

* Minor patient (age \<18 years).
* Patient under trusteeship, curatorship or protective measures.
* Patient who has already completed the questionnaire.
* Patient not sufficiently able to speak French to answer the questionnaire

Primary outcomes:
measure: Validate the 9 dimensions of the CANUT-QVA questionnaire identified during the general population analysis.
timeFrame: day 0
Secondary outcomes:
Other outcomes:
Locations:
city: Pierre-Bénite
country: France
facility: Hospices Civils de Lyon, Groupement Hospitalier Lyon Sud, Service pneumologie
Study officials:
References: