Clinical trial NCT03874624: Normal Values for Myocardial Left Atrial Strain
Official title: Normal Values for Myocardial Left Atrial Strain
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Atrial Function
Lead sponsor: Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
Sponsor class: OTHER
First posted: 2019-03-14
Enrollment: 43
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: COHORT
Time perspective: RETROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Healthy controls.

Brief summary: Transversal retrospective and unicentric study. The investigators sought to determine the normal values for two-dimensional myocardial left atrial strain for the cardiology ultrasound system available in their centre (Philips EPIQ ultrasound machine and 10.8.5 QLAB cardiac analysis software). Studies performed in their department which meet the criteria for an adequate strain analysis will be retrospectively reviewed.


Eligibility criteria: Inclusion Criteria:

* No history of cardiopathy / pneumopathy.
* No history of hypertension or mellitus diabetes.

Exclusion Criteria:

* Pregnancy.
* Athletes.
* Body mass index \< 16 or =\> 30 kg/m2.
* Previous treatment with cardiotoxic chemotherapy.
* Dilated left ventricle (telediastolic diameter index \> 30 mm/m2).
* Interventricular septal thickness =\> 12 mm.
* Dilated left atria (volume =\> 31 ml/m2).
* Systolic pulmonary pressure =\> 35 mmHg.
* Moderate or severe valvulopathy.
* Incomplete or suboptimal left atrial visualization.
* Frame rate \< 50 fps.

Primary outcomes:
measure: Global peak reservoir strain.
timeFrame: Through study completion, an average of 4 months.
measure: Global pump strain.
timeFrame: Through study completion, an average of 4 months.
measure: Global conductance strain.
timeFrame: Through study completion, an average of 4 months.
measure: Global reservoir strain rate.
timeFrame: Through study completion, an average of 4 months.
measure: Global conductance strain rate.
timeFrame: Through study completion, an average of 4 months.
measure: Global pump strain rate.
timeFrame: Through study completion, an average of 4 months.
Secondary outcomes:
measure: Age in years
timeFrame: Through study completion, an average of 4 months.
measure: Sex
timeFrame: Through study completion, an average of 4 months.
measure: Weight in kilograms
timeFrame: Through study completion, an average of 4 months.
measure: Height in meters
timeFrame: Through study completion, an average of 4 months.
measure: Left atrial volume
timeFrame: Through study completion, an average of 4 months.
measure: Left ventricular ejection fraction
timeFrame: Through study completion, an average of 4 months.
measure: Left ventricular telediastolic volume
timeFrame: Through study completion, an average of 4 months.
measure: Left ventricular dimensions
timeFrame: Through study completion, an average of 4 months.
measure: E/A ratio
timeFrame: Through study completion, an average of 4 months.
measure: E/e' ratio
timeFrame: Through study completion, an average of 4 months.
Other outcomes:
Locations:
city: Barcelona
country: Spain
facility: Hospital de la Santa Creu i Sant Pau
Study officials:
References: