Clinical trial NCT05371119: BFR in Overweight Sedentary Subjects
Official title: Effects of a Physical Activity Program With Partial Vascular Occlusion on Body Composition, Biomechanics and Walking Energy in Overweight Sedentary Subjects
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Overweight
Keywords: blood flow restriction
Lead sponsor: University of Lausanne
Sponsor class: OTHER
First posted: 2022-05-12
Enrollment: 30
Sex: ALL
Minimum age (years): 20
Maximum age (years): 60
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Intervention model description: The procedure will consist of 6 weeks of training with or without partial vascular occlusion (depending on group A or group B) at the rate of 3 sessions per week (for a total of 18 training sessions).
Primary purpose: BASIC_SCIENCE

Brief summary: This project should allow the investigators to observe the effects of low load training under partial vascular occlusion (BFR) in comparison with resistance training at low load without partial vascular occlusion in sedentary people overweight on parameters : decrease in fat mass; increase in muscle mass 79; muscle strength; decrease in the energy cost of walking; increase in preferred walking speed; improvement in walking pattern in patients overweight. Training under partial vascular occlusion should facilitate physical activity in overweight people as it can be just as effective as a "classic" type training with heavy loads. Thus, this device could allow people for who wear heavy loads can present an obstacle to physical activity to feel more involved in the physical activity programs offered in medical or sports centers.

Detailed description: The main objective of this study is to observe the effects of low load training under vascular occlusion (BFR) compared with low load resistance training without vascular occlusion in overweight sedentary people on parameters such as: decrease in fat mass; lower blood sugar levels as well as lower blood triglycerides and cholesterol levels; increased muscle mass; muscle strength; the reduction of the energy cost of walking; increasing the preferred walking speed; improving the walking pattern in overweight patients.

3.2 Primary and secondary endpoints

The first hypothesis is that the BFR drive will be effective in improving walking economy (thus reducing the energy cost of walking) and increasing the preferred walking speed, by improving walking patterns.

The second hypothesis is that BFR training makes it possible to modify the body composition in a slight way and to promote the gain of muscle strength in overweight individuals who do not practice physical activity beforehand. In addition, blood tests will show a decrease in blood sugar, blood triglyceride levels and cholesterol.

3.3 Study design

This single-center project aims to test the effects of low-load training under partial vascular occlusion (BFR) compared to low-load resistance training without vascular occlusion in overweight sedentary people. The main expected effects are a decrease in fat mass, an increase in muscle mass and strength, a decrease in the energy cost of walking as well as an increase in preferential walking speed. This project is part of a continuity of research in a public health context in order to propose adapted and effective physical activity programs for an overweight population unable to train with heavy loads.

Eligibility criteria: Inclusion Criteria:

* IMC between 25 and 35
* vaccin against Covid-19

Exclusion Criteria:

hypertension diabete

Primary outcomes:
measure: DEXA technology
timeFrame: One week before intervention
measure: DEXA technology
timeFrame: One week following the training intervention
measure: Evaluation of muscle strength from an isokinetic device
timeFrame: One week before intervention
measure: Evaluation of muscle strength from an isokinetic device
timeFrame: One week following the training intervention
measure: Evaluation of the preferential speed of walking in an ecological situation
timeFrame: One week before interventionn
measure: Evaluation of the preferential speed of walking in an ecological situation
timeFrame: One week following the training intervention
measure: Analysis of the biomechanics of walking on a treadmill instrumented with power platforms.
timeFrame: One week before intervention
measure: Analysis of the biomechanics of walking on a treadmill instrumented with power platforms.
timeFrame: One week following the training intervention
measure: Evaluation of the energy cost of walking
timeFrame: One week before intervention
measure: Evaluation of the energy cost of walking
timeFrame: One week following the training intervention
Secondary outcomes:
Other outcomes:
Locations:
city: Lausanne
country: Switzerland
facility: ISSUL
state: VD
Study officials:
References: