Clinical trial NCT02664441: Energy Balance & Weight Loss in Craniopharyngioma-related or Other Hypothalamic Tumors in Hypothalamic Obesity
Official title: Glucagon-Like Peptide-1 Agonist Effects on Energy Balance in Hypothalamic Obesity
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE3
Conditions: Hypothalamic Obesity
Keywords: Obesity
Drug intervention
Children
Adolescents
Young adults
Hypothalamic lesion
Change of weight status
Food intake
Energy expenditure
Hormonal changes
Glucagon-like peptide-1 agonist
Bydureon
Weight Loss
Energy balance
Lead sponsor: Seattle Children's Hospital
Sponsor class: OTHER
Collaborators: name: Children's Hospitals and Clinics of Minnesota
name: Vanderbilt University
First posted: 2016-01-27
Enrollment: 42
Sex: ALL
Minimum age (years): 10
Maximum age (years): 25
Standard ages: CHILD
ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The proposed multicenter study will test the effect of glucagon-like peptide (GLP)-1 agonist exenatide once weekly extended-release (ExQW, Bydureon®) on clinical outcomes and metabolic parameters in a double-blind, placebo-controlled 36 week randomized trial with an 18 week open label extension. Following baseline testing, 48 patients will be randomly assigned with equal allocation to ExQW or matching placebo injection for 36 weeks, followed by an 18 week open label extension during which all patients receive ExQW. Changes of weight status, body composition, free-living total daily energy expenditure (EE) by doubly labeled water (DLW), activity by acetimetry, energy intake (questionnaires and food diary), as well as glucose tolerance and hormonal parameters of energy homeostasis and insulin resistance will be assessed before treatment and at the end of the placebo-controlled phase (week 36). Activity, metabolic outcomes, energy intake will be also assessed at study week 18 (mid treatment of randomized study), as well as week 54 (end of open label treatment).

Detailed description: Excessive weight gain and its cardiometabolic sequela are frequent complications of hypothalamic tumors, a condition known as hypothalamic obesity (HO). Most tumors in this region are craniopharyngiomas (CP),1 which constitute 5-9% of childhood brain tumors. Patients with CP typically become obese and have more features of the metabolic syndrome compared to matched controls. Overall, a 3-19-fold higher cardiovascular mortality had been reported, and a recent nationwide population-based study in Sweden demonstrated increased rates for cerebral infarction (7-fold), death due to cerebrovascular diseases (5-fold), and type 2 diabetes mellitus (6-fold) in CP patients in comparison to the general population. Thus, early and effective management of obesity is vital for this population, which is more resistant to treatment than uncomplicated obesity. Recognized risk factors for severe obesity include large hypothalamic tumors or lesions affecting several medial and posterior hypothalamic nuclei that impact satiety signaling pathways. Structural damage in these nuclei often lead to uncontrolled appetite, rapid weight gain, central insulin and leptin resistance, decreased sympathetic activity, low energy expenditure (EE), and increased energy storage in adipose tissue. Recently, the investigators developed a semi-quantitative assessment of hypothalamic damage on brain magnetic resonance imaging (MRI) to predict the risk for HO development in CP.

Previous results of treating HO with a glucagon-like-peptide-1 receptor agonist (GLP1RA) in rats and humans provide promising proof-of-principle data to support this current randomized clinical trial. The primary hypothesis of this study is that drugs causing weight loss via intact hindbrain signaling pathways offer a desperately needed option for treatment of HO, even in very obese HO subjects with severe hypothalamic damage. Induction of weight loss by GLP1RAs is believed to be related to multiple mechanisms involving the gastrointestinal tract, vagus nerve, and the brain leading to increased satiety. Peripheral administration of GLP-1 or GLP1RA reduces blood glucose and energy intake in humans and rodents, and long-term treatment results in loss of body weight. Critically, the investigators do not know whether GLP1RA treatment affects EE and activity, or whether the site and size of brain lesions affect responses to GLP1RA treatment.

The investigators' previous clinical studies of the GLP1RA exenatide in obese adolescents and adults have generated the critical safety and efficacy data needed to design a clinical trial. In a pilot study conducted at Children's Hospitals and Clinics of MN, pretreatment hyperphagia was associated with BMI reduction. Using these data, the investigators have designed a prospective, multicenter trial that will examine the effects of GLP1RA on BMI, cardiovascular disease (CVD) risk factors, energy homeostasis and other factors in subjects with HO secondary to CP.

Eligibility criteria: Inclusion Criteria:

* Age 10-25 years at time of enrollment
* Diagnosis of hypothalamic obesity with age- and sex adjusted BMI ≥ 95% or BMI ≥30 kg/m² if over 18 y
* History of craniopharyngioma or another tumor located in the hypothalamic area
* Hypothalamic lesion documented by neuroradiology
* ≥ 6 months post-surgical or radiation treatment
* Weight stable or increasing over 3 months prior to screening visit
* Stable hormone replacement for at least 3 months prior to screening visit

Exclusion Criteria:

* Renal impairment (GFR\<60 ml/min/1.73m² using the Schwarz formula)
* History of gastroparesis; pancreatitis or gallstones (unless status post cholecystectomy)
* Family history of multiple endocrine neoplasia type 2 or familial medullary thyroid carcinoma metabolic disorders
* Any insulin-treated diabetes mellitus, poorly controlled type 2 diabetes (HbA1c ≥ 10%), or any other chronic serious medical conditions such as cardiovascular disease, malignancy or hematologic disorder, complicated syndromic disorder, or psychiatric disorders (schizophrenia, major depression, history of suicide attempts)
* Calcitonin \>50 mg/L at screening
* Initiation of weight loss medications within 3 months of screening visit
* Previous donation of blood \>10% of estimated blood volume within 3 months prior study
* Current warfarin use
* Current use of any other GLP1 receptor agonist
* Untreated thyroid disorder or adrenal insufficiency
* History of bariatric surgery or planned bariatric surgery until end of study
* Pregnancy, lactation or expectation to conceive during study period
* Subject unlikely to adhere to study procedures in opinion of investigator
* Subject with contraindication to neuroimaging by MRI

Primary outcomes:
measure: Percent Change of Body Mass Index (BMI) as Calculated by the Formula: Body Weight in kg Divided by Height in Meters².
timeFrame: From baseline to 36 weeks
Secondary outcomes:
measure: Changes in Body Composition as Assessed by Body Fat Mass Using Dual Energy X-ray Absorptiometry (DEXA)
timeFrame: At baseline and 36 weeks
measure: Changes in Fat and Total Calorie Intake Assessed by Free Buffet Meal Analysis.
timeFrame: From baseline to 36 weeks
measure: Changes in Fasting Glucose
timeFrame: From baseline to 36 weeks
measure: Changes in HDL Cholesterol and Triglycerides Assessed by Fasting Lipids
timeFrame: From baseline to 36 weeks
measure: Changes in Inflammation Assessed by C-reactive Protein (CRP)
timeFrame: From baseline to 36 weeks
measure: Changes of Insulin Resistance Assessed by Homeostasis Model Assessment of Insulin Resistance (HOMA-IR)
timeFrame: From baseline to 36 weeks
measure: Changes of Circulating Leptin Levels
timeFrame: From baseline to 36 weeks
measure: Changes of Energy Expenditure Assessed by Doubly Labeled Water Analysis
timeFrame: Baseline and 36 weeks
measure: Changes of Energy Intake Assessed by Automated Self-Administered 24-Hour Dietary Recall (ASA24-Kids)
timeFrame: Baseline and 36 weeks
measure: Changes in Glucose 120 Minutes Following an Oral Glucose Tolerance Test
timeFrame: From baseline to 36 weeks
Other outcomes:
Locations:
city: Minneapolis
country: United States
facility: Children's Hospitals adn Clinics of Minnesota
state: Minnesota
city: Nashville
country: United States
facility: Vanderbilt University School of Medicine
state: Tennessee
city: Seattle
country: United States
facility: Seattle Childrens
state: Washington
Study officials:
affiliation: Seattle Childrens
name: Christian Roth, MD
role: PRINCIPAL_INVESTIGATOR
References: