Clinical trial NCT05534854: Frequency, Clinical Phenotype and Genetic Analysis of Heritable Kidney Cancer Syndromes
Official title: Frequency, Clinical Phenotype and Genetic Analysis of Heritable Kidney Cancer Syndromes
Study type: OBSERVATIONAL
Overall status: RECRUITING
Conditions: Renal Tumor Histology
Kidney Cancer
Renal Cell Carcinoma
Familial Renal Cancer
HLRCC
VHL Syndrome
BAP1 Tumor Predisposition Syndrome
FLCN Gene Mutation
ALK Gene Mutation
FH Gene Mutation
Birt-Hogg-Dube Syndrome
MET Gene Mutation
Cutaneous Leiomyoma
Cutaneous Leiomyomata With Uterine Leiomyomata
Lead sponsor: RenJi Hospital
Sponsor class: OTHER
Collaborators: name: Ruijin Hospital
name: Shanghai Zhongshan Hospital
name: Huashan Hospital
name: Xinhua Hospital, Shanghai Jiao Tong University School of Medicine
name: Zhejiang Provincial People's Hospital
name: Tongji Hospital
name: Second Affiliated Hospital, School of Medicine, Zhejiang University
name: Shanghai 10th People's Hospital
name: First Affiliated Hospital, Sun Yat-Sen University
name: Peking University First Hospital
First posted: 2022-09-10
Enrollment: 500
Sex: ALL
Minimum age (years): 2
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Patients with known or suspected heritable kidney cancer syndromes and their biologic family members with heritable kidney cancer syndromes will be recruited primarily from the urology, oncology, and genetics communities worldwide.

Brief summary: This study will investigate the frequency, clinical phenotype, management and molecular genetic defects of heritable kidney cancer syndromes. Families with kidney cancer with known or suspected genetic basis will be enrolled. Affected individuals or individuals suspected of having a germline kidney cancer will undergo periodic clinical assessment and genetic analyses for the purpose of: 1) definition and characterization of phenotype, 2) determination of the natural history of the disorder, and 3) genotype/phenotype correlation. Genetic linkage studies may be performed in situations in which the genetic basis of the disorder has not been elucidated. This research will have a significant impact on the overall management of heritable kidney cancer syndromes patients and family members who are at risk for heritable kidney cancer syndromes. The study will ultimately facilitate the development of novel screening, prevention and treatment strategies for these individuals with the syndrome. In addition this study could have impact on the management of patients with personal and/or family history of heritable kidney cancer syndromes.

Detailed description: Background:

• The genetic etiology of heritable kidney cancer syndromes remains to be determined.

Objectives:

* Define the risk of developing renal cance in heritable kidney cancer syndromes
* Define the types and characteristics (including patterns of growth) of heritable kidney cancer syndromes.
* Determine genotype/phenotype correlations.
* To characterize the natural and clinical histories of heritable kidney cancer syndromes.
* To determine the genetic etiology of heritable kidney cancer syndromes.

Design:

* These rare families will be recruited to genetically confirm diagnosis, determine size and location of renal tumors, size at presentation, growth rate and metastatic potential of renal tumors.
* Genetic testing will be offered to gain appreciation of the effect of mutations on the relative activity of various germline and somatic mutations.
* To determine if there is a relationship between mutation and disease manifestations and phenotype.

Eligibility criteria: Inclusion Criteria:

* Participants must be greater than or equal to 2 years of age. All patients and guardians (for children younger than 18 years of age) must sign an informed consent document indicating their understanding of the investigational nature and the risks of this study before any protocol related studies are performed. Patients under the age of 18 but who are age 13 or older will be asked to sign an assent document prior to participation.
* Individuals and biologic family members with a suspected or an established diagnosis of a heritable kidney cancer syndrome in which the disease gene is known, including von Hippel-Lindau (VHL) and hereditary papillary renal carcinoma (HPRC).
* Individuals and biologic family members with a suspected or an established diagnosis of a heritable kidney cancer syndrome in which the disease gene is not yet known, specifically hereditary forms of Type II papillary renal cancer, clear cell renal carcinoma, renal oncocytoma, chromophobe renal carcinoma or Birt Hogg Dube.
* Individuals and biologic family members who have heritable kidney cancer syndromes of suspected, but not proven genetic etiology, including families with more than one individual affected by the same or related cancers.
* Subject Enrollment Categories (to include both affected and unaffected biologic relatives).

Exclusion Criteria:

* Pregnant women are excluded from enrollment onto this study because there is no direct benefit for participating in the study.

Primary outcomes:
measure: Clinical phenotypes of patients of heritable kidney cancer syndromes
timeFrame: 5 years
measure: Genotypes of patients of heritable kidney cancer syndromes
timeFrame: 5 years
Secondary outcomes:
measure: Clinical phenotypes of family members of the patients
timeFrame: 5 years
measure: Prevalence of germline variants in the unselected general population of renal cancer patients
timeFrame: 5 years
Other outcomes:
Locations:
city: Shanghai
country: China
facility: Ethics Committee of Shanghai Renji Hospital
state: Shanghai
Study officials:
affiliation: RenJi Hospital
name: Jin Zhang
role: STUDY_CHAIR
References: