Clinical trial NCT04216836: One Week of Magnesium Supplementation Lowers IL-6, Perceived Pain and Increases Post Exercise Blood Glucose in Response to Downhill Running
Official title: One Week of Magnesium Supplementation Lowers IL-6, Perceived Pain and Increases Post Exercise Blood Glucose in Response to Downhill Running
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Magnesium Deficiency
Keywords: Magnesium
Supplementation
Interleukin-6
Soluble interleukin-6 receptor
Glucose
Pain
Exercise performance
Exercise recovery
Downhill running
Lead sponsor: University of Worcester
Sponsor class: OTHER
Collaborators: name: Beijing Sport University
name: Coventry University
First posted: 2020-01-03
Enrollment: 9
Sex: MALE
Minimum age (years): 20
Maximum age (years): 35
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: CROSSOVER
Primary purpose: PREVENTION

Brief summary: This study investigated the effect of magnesium supplementation on exercise performance and functional recovery in recreational endurance athletes in conjunction with measures of blood glucose, lactate, IL-6 and sIL-6R.

Detailed description: Magnesium status can directly affect circulating glucose concentrations both during and post exercise. In addition, magnesium supplementation has been shown to reduce circulating IL-6 concentrations post exercise in humans. It is conceivable that such observations are linked through the role of IL-6 in glucose regulation, possibly in combination with sIL-6R. Together, magnesium intake may have the potential to effect exercise performance and recovery through glucose availability. This in turn may be connected to the production of IL-6 and sIL-6R which have been established to influence exercise fatigue and perception of pain (muscle soreness).

Eligibility criteria: Inclusion Criteria:

* Regular recreational runner, running around 3 times per week
* Capable of running 10 km in \~ 40 minutes.

Exclusion Criteria:

* Any signs or symptoms of cardiovascular issues.
* Any recent form of injury or illness.
* Currently, or in the last 3 months, have consumed multivitamin supplements
* Currently, or in the last 3 months, have consumed anti-inflammatory medications.

Primary outcomes:
measure: Downhill 10 km treadmill time trial performance
timeFrame: 1 day
measure: 24 hr post exercise maximal force testing of the dominant leg on the isokinetic dynamometer
timeFrame: 1 day
Secondary outcomes:
measure: Glucose
timeFrame: up to 2 days
measure: Interleukin-6
timeFrame: up to 2 days
measure: Soluble interleukin-6 receptor
timeFrame: up to 2 days
measure: Perceived muscle soreness
timeFrame: up to 4 days
measure: Lactate
timeFrame: up to 2 days
measure: Creatine kinase
timeFrame: up to 2 days
Other outcomes:
Locations:
city: Worcester
country: United Kingdom
facility: University of Worcester
state: Worcestershire
Study officials:
References:
citation: Chen HY, Cheng FC, Pan HC, Hsu JC, Wang MF. Magnesium enhances exercise performance via increasing glucose availability in the blood, muscle, and brain during exercise. PLoS One. 2014 Jan 20;9(1):e85486. doi: 10.1371/journal.pone.0085486. eCollection 2014.
citation: Chen YJ, Chen HY, Wang MF, Hsu MH, Liang WM, Cheng FC. Effects of magnesium on exercise performance and plasma glucose and lactate concentrations in rats using a novel blood-sampling technique. Appl Physiol Nutr Metab. 2009 Dec;34(6):1040-7. doi: 10.1139/H09-105.
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citation: Gray SR, Ratkevicius A, Wackerhage H, Coats P, Nimmo MA. The effect of interleukin-6 and the interleukin-6 receptor on glucose transport in mouse skeletal muscle. Exp Physiol. 2009 Aug;94(8):899-905. doi: 10.1113/expphysiol.2009.048173. Epub 2009 May 29.
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