louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT00846313: Can Malnutrition be Prevented in Patient With Colorectal Cancer Stage Dukes D?
Official title: A Randomised Study of Dietary Counseling for Patients With Colorectal Cancer.
Study type: INTERVENTIONAL
Overall status: WITHDRAWN
Phase: NA
Conditions: Colorectal Neoplasm
Keywords: Dietary intake
Dietary counseling
Weight loss
Body composition
Resting energy expenditure
Quality of life
Lead sponsor: Norwegian University of Science and Technology
Sponsor class: OTHER
Collaborators: name: St. Olavs Hospital
First posted: 2009-02-18
Enrollment: 0
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: SINGLE_GROUP
Primary purpose: SUPPORTIVE_CARE

Brief summary: The purpose of this randomised intervention study is to investigate to what degree patients with colorectal cancer benefit of dietary counselling regarding nutritional status, oncologic treatment and quality of life.


Eligibility criteria: Inclusion Criteria:

* metastatic colorectal cancer
* histological verified cancer
* age \>18 years

Exclusion Criteria:

* cognitive reduction
* confusion
* not able to answer questionaire

Primary outcomes:
measure: Body weight
timeFrame: 2 year
Secondary outcomes:
measure: Body composition
timeFrame: 2 year
measure: Quality of life
timeFrame: 2 years
measure: Oncologic treatment
timeFrame: 2 years
measure: Dietary intake
timeFrame: 2 years
Other outcomes:
Locations:
Study officials:
affiliation: St. Olavs Hospital, NTNU
name: Lene Thoresen, MSc
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT02350036: Placental Protein 13 Serum Endoglin and Uterine Doppler Indeces as Predictors of Pre-eclampsia
Official title: Maternal Serum Placental Protein 13 Serum Endoglin and Uterine Doppler Indeces as Predictors of Pre-eclampsia and Relation to Maternal and Neonatal Outcome
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Preeclampsia
Keywords: Preeclampsia
placental protein 13
Uterine artery doppler
Lead sponsor: Cairo University
Sponsor class: OTHER
First posted: 2015-01-29
Enrollment: 50
Sex: FEMALE
Minimum age (years): 20
Maximum age (years): 40
Standard ages: ADULT
Accepts healthy volunteers: yes
Observational model: CASE_CONTROL
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: pregnant women at 11 to 14 weeks of gestation

Brief summary: 50 pregnant females were divided in two groups, twenty five as a control group and twenty five as high risk group; they were subjected to uterine artery Doppler, measurement of maternal serum and detection of (MTHFR) gene polymorphisms in first trimester at 11 to 14 weeks of gestation, all pregnancies were followed until 40 weeks for development of pre-eclampsia

Detailed description: 50 pregnant females were divided in two groups, twenty five as a control group and twenty five as high risk group; they were subjected to uterine artery Doppler, measurement of maternal serum (pp-13) and detection of (MTHFR) gene polymorphisms in first trimester at 11 to 14 weeks of gestation, all pregnancies were followed until 40 weeks for development of pre-eclampsia

Eligibility criteria: Inclusion Criteria:

* pregnant women at 11 to 14 weeks of gestation

Exclusion Criteria:

* fetal anomalies other medical diseases as diabetes mellitus, renal or liver diseases

Primary outcomes:
measure: development of preeclampsia
timeFrame: 40 weeks pregnancy
Secondary outcomes:
Other outcomes:
Locations:
city: Cairo
country: Egypt
facility: Kasr Alainy medical school
Study officials:
affiliation: Kasr Alainy medical school
name: Ahmed Maged
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT00353236: The Contribution of Internal Maternal Resources to Creation of Motherhood. Comparison Among Mothers to Twins and Singleton
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Preterm Birth
Keywords: delivery of preterm infant and/or twins
Lead sponsor: Sheba Medical Center
Sponsor class: OTHER_GOV
First posted: 2006-07-18
Sex: ALL
Minimum age (years): 0
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: CASE_CONTROL
Time perspective: PROSPECTIVE

Brief summary: Delivery of twins or preterm infant is a very stressful episode to mothers. The purpose of this study is to characterize maternal psychological resources in dealing with this situation and compare it to mothers giving birth to singleton at term


Eligibility criteria: Inclusion Criteria:

* Study group: Mothers who give birth to twins or preterm infants
* Control: Mothers who give birth to singleton, full term infants

Exclusion Criteria:

* None

Primary outcomes:
Secondary outcomes:
Other outcomes:
Locations:
city: Ramat -Gan
country: Israel
facility: Sheba Medical Center - Neonatal Department
Study officials:
affiliation: Sheba Medical Center
name: Jacob Kuint, MD
role: STUDY_DIRECTOR
References:
Clinical trial NCT05187936: Pre-clinical Models for Mesenchymal Stem Cell Therapy in Hemophilic Arthropathy
Official title: Pre-clinical Models for Mesenchymal Stem Cell Therapy in Hemophilic Arthropathy
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Hemophilia A
Hemophilia B
Arthropathy
Keywords: mesenchymal stem cells
Healthly control
Lead sponsor: University Hospital, Montpellier
Sponsor class: OTHER
First posted: 2022-01-12
Enrollment: 200
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: OTHER
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Hemophilia A or B patient, with or without arthropathy

Brief summary: Hemophilia is a constitutional coagulation disorder responsible for a hemorrhagic phenotype in patients from an early age. Hemarthrosis is one of the most frequent complications in hemophiliacs and leads to the development of severe and early arthropathy, sometimes as early as childhood. To date, there is no curative treatment for these joint disorders and preventive treatments are insufficient to completely prevent joint degradation. Mesenchymal stem cells have been shown to be of therapeutic interest in the management of pathologies such as osteoarthritis and inflammatory arthritis through their anti-inflammatory, regenerative and anti-apoptotic effects. Hemophilic arthropathy is a separate condition at the border of these two diseases Our study aim to show pre-clinical interest of mesenchymal stem cell therapy in hemophilic arthropathy


Eligibility criteria: Inclusion criteria:

* Hemophilia A or B adult patient, with or without arthropathy
* Heathly control

Exclusion criteria:

* Antiinflammatory drug use
* immunosuppressive treatment or condition

Primary outcomes:
measure: Evaluation of surviva
timeFrame: 1 day
measure: Evaluation of proliferation
timeFrame: 1 day
measure: Evaluation of apoptosis, phenotype, function of cells
timeFrame: 1 day
measure: Evaluation of phenotype
timeFrame: 1 day
Secondary outcomes:
Other outcomes:
Locations:
city: Montpellier
country: France
facility: Uhmontpellier
Study officials:
affiliation: University Hospital, Montpellier
name: Alexandre THERON
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT04164836: Effect of Nose Selection Using Rhnoscope on Epistaxis of Nasotracheal Intubation
Official title: The Effect of Suitable Nose Selection Using Rhinoscope on the Incidence and Severity of Epistaxis After Nasotracheal Intubation.
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Nasotracheal Intubation
Keywords: epistaxis
rhinoscope
Lead sponsor: Ajou University School of Medicine
Sponsor class: OTHER
First posted: 2019-11-15
Enrollment: 182
Sex: ALL
Minimum age (years): 19
Maximum age (years): 70
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: DIAGNOSTIC

Brief summary: Rhinoscope is useful to exam intranasal structure. This information could be utilized to select more suitable nose for nasotracheal intubation. Nastoracheal intubation using more patent nose could be associated with decrease of the development of epistaxis which is most common complication in nasotracheal intubation.

Detailed description: Anterior rhinoscopy using rhinoscope is a simple way to view the intranasal structure, which allows you to observe the nasal mucosa, the inferior nasal concha, and in some cases, the nasal concha. You can see the nasal septum, polyps, and intranasal malformations. In addition, even when there are no structural abnormalities in the nasal cavity, the wider nasal cavity can be intuitively identified. This information is expected to assist in the selection of nostrils. It has not yet been studied whether anesthesiologists select nasal cavity for nasotracheal intubation using prosthesis can affect the occurrence of epistaxis.

The purpose of this study is to determine whether the selection of a nostril for nasotracheal intubation by rhinoscope affects the incidence and severity of epistaxis.

Eligibility criteria: Inclusion Criteria:

* ASA I or II undergoing surgery under nasotracheal intubation

Exclusion Criteria:

* expected difficult intubation based on history, physical examination, weight.
* bleeding tendency
* past history of nasal surgery
* symptom of difficulty of nasal respiration

Primary outcomes:
measure: incidence of epistaxis
timeFrame: immediate after intubation
measure: incidence of epistaxis
timeFrame: 5 min after intubation
Secondary outcomes:
measure: severity of epistaxis4. severe: interfere intubation by blood
timeFrame: immediate after intubation
measure: severity of epistaxis
timeFrame: 5 min after intubation
Other outcomes:
Locations:
city: Suwon-si
country: Korea, Republic of
facility: Ajou universitiy school of medicine
state: Gyeong-gi Do
Study officials:
affiliation: Ajou University School of Medicine
name: yun jeong chae, PhD MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT03392636: Comparison of Recurrence Rate of 2 Herniotomy Techniques in Children Older Than 2 Years
Official title: Comparison of Recurrence Rate of Ferguson & Gross Herniotomy With Mitchell Banks Herniotomy in Children Older Than 2 Years
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Hernia, Inguinal
Lead sponsor: King Edward Medical University
Sponsor class: OTHER
First posted: 2018-01-08
Enrollment: 260
Sex: ALL
Minimum age (years): 2
Maximum age (years): 13
Standard ages: CHILD
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Intervention model description: Group A will get Mitchell Banks herniotomy done and Group B will get Fergusson Gross Herniotomy done.
Primary purpose: TREATMENT

Brief summary: the study is basically aimed at comparing two techniques of herniotomy by comparing there recurrence rates

Detailed description: in this study, the principal investigator will operate upon patients aged between 2 years and 12 years by two techniques. in technique called mitchell banks technique, inguinal canal will not be opened and in Fergusson gross technique, it will be opened

Eligibility criteria: Inclusion Criteria:

* All pediatric patients of either gender above age of 2 years and below 14 years of age presenting in pediatric surgery Mayo hospital lahore

Exclusion Criteria:

* sliding hernia strangulated hernia pts with connective tissue disorders pts with undesccended testis patients with hydrocele hernia with internal ring 2cm or more in size

Primary outcomes:
measure: recurrence
timeFrame: 6 months
Secondary outcomes:
measure: size of incision
timeFrame: upto 6 months, will be noted at the end of every procedure
measure: operation time
timeFrame: upto 6 months, will be noted at the end of every procedure
measure: Intra operative complications
timeFrame: upto 6 months, will be noted at the end of every procedure
measure: post-operative complications
timeFrame: will be noted on follow up at 7 days post op
measure: Testicular Atrophy
timeFrame: 6 months after procedure
Other outcomes:
Locations:
city: Lahore
country: Pakistan
facility: KEMU
state: Punjab
Study officials:
References:
Clinical trial NCT02010736: Loading Gait in Spatic Cerebral Palsy
Official title: Immediate Effects of a Single Treadmill Gait Training Session With Additional Loading on Kinematic Gait Parameters in Children With Spastic Cerebral Palsy
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Spastic Hemiplegic Cerebral Palsy
Keywords: Cerebral palsy
Gait
Weight Bearing
Rehabilitation
Lead sponsor: Universidade Federal do Rio Grande do Norte
Sponsor class: OTHER
Collaborators: name: Coordenação de Aperfeiçoamento de Pessoal de Nível Superior.
First posted: 2013-12-13
Enrollment: 20
Sex: ALL
Minimum age (years): 5
Maximum age (years): 13
Standard ages: CHILD
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: TREATMENT

Brief summary: The purpose of this study is to observe the behavior of kinematic variables in children with spastic hemiparetic cerebral palsy (SHCP), immediately after treadmill gait training with ankle loading.

The children underwent a single treadmill training session with ankle loading. The kinematic parameters were assessed in three phases: before training (PRE); immediately after training (POST); and 5 minutes after the end of training (FOLLOW UP).

The investigators hypothesized that the treadmill gait training with additional lower limb loading would be a disturbance capable of modifying the locomotor strategy of children with SHCP, by the increase in kinematic parameters in the swing phase of gait.


Eligibility criteria: Inclusion Criteria:

* Spastic Hemiparetic Cerebral Palsy;
* Being able to walk without an assistive device (levels I or II of the Gross Motor Function Classification System - GMFCS);
* Not having undergone muscle lengthening surgery within the previous year;
* Not having applied botulin toxin to the lower limbs or serial casting in the previous 6 months.

Exclusion Criteria:

* Inability to understand simple commands to perform the training and evaluation;
* Inability to walk on the treadmill with or without load on the lower limbs;
* Presence of any physical pain or discomfort during the course of training.

Primary outcomes:
measure: Changes in kinematic gait parameters after treadmill trainning with ankles loading
timeFrame: Immediately after training with ankles loading (POST phase)
Secondary outcomes:
measure: Changes in kinematic gait parameters after five minutes of rest
timeFrame: After five minutes of rest (FOLLOW UP phase)
Other outcomes:
Locations:
city: Natal
country: Brazil
facility: Universidade Federal do Rio Grande do Norte
state: RN
Study officials:
affiliation: Universidade Federal do Rio Grande do Norte
name: Camila R Simão, MSc
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT01321736: Gut Health Response to Dietary Fiber
Official title: Gut Health Response to a New Fiber Blend
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Dietary Fiber
Keywords: dietary fiber
enteral nutrition
laxation
Lead sponsor: University of Minnesota
Sponsor class: OTHER
Collaborators: name: Société des Produits Nestlé (SPN)
First posted: 2011-03-23
Enrollment: 20
Sex: ALL
Minimum age (years): 18
Maximum age (years): 75
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: CROSSOVER
Primary purpose: PREVENTION

Brief summary: Dietary fiber is known to influence bowel function. The investigators hypothesize that the addition of a mixture of fibers to liquid diets will improve bowel function as measured by stool weight.

Detailed description: Liquid diets are the sole source of nutrition for many patients. Consumption of liquid diets is linked to lower stool weight. The objective of this study is to feed liquid diets, with and without added fiber, to healthy human subjects to determine if mixed fiber sources can normalize stool weight. Secondary objectives of the study include measurement of gut microbiota and stool chemistry with fiber addition.

Eligibility criteria: Inclusion Criteria:

1.Weight

* BMI between 23 - 29
* having obtained his/her informed consent
* willing and able to exclusively consume enteral diets for two 14 day periods
* willing and able to collect stool samples as instructed

Exclusion Criteria:

* any disease
* use of medication except for contraceptive medication and certain OTC medications not affecting laxation
* smoking
* excessive exercise (\> 2 hours per week)
* consumption of more than 20 grams of dietary fiber daily
* pregnancy or lactation
* use of laxatives
* use of antibiotics in past 6 months
* use of pre or probiotics supplements in the past 2 months
* use of probiotic foods in the past month
* subjects who cannot be expected to comply with the study procedures
* currently participating or having participated in another clinical trial during the last 4 weeks prior to the beginning of this study
* known allergy or sensitivity to formula ingredients

Primary outcomes:
measure: Stool weight
timeFrame: 5 day collection
Secondary outcomes:
measure: fecal microbiota
timeFrame: day 14 of feeding trial
Other outcomes:
Locations:
city: St. Paul
country: United States
facility: University of Minnesota
state: Minnesota
Study officials:
affiliation: University of Minnesota
name: Joanne Slavin, PhD
role: PRINCIPAL_INVESTIGATOR
References:
citation: Koecher KJ, Thomas W, Slavin JL. Healthy subjects experience bowel changes on enteral diets: addition of a fiber blend attenuates stool weight and gut bacteria decreases without changes in gas. JPEN J Parenter Enteral Nutr. 2015 Mar;39(3):337-43. doi: 10.1177/0148607113510523. Epub 2013 Nov 14.
Clinical trial NCT05306236: Efficacy of Adding LLL Therapy to Postural Correction Exercises on Postnatal SIJ Pain
Official title: Efficacy of Adding Low Level Laser Therapy to Postural Correction Exercises on Postnatal Sacroiliac Joint Pain
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Sacroiliac Joint Pain
Lead sponsor: Cairo University
Sponsor class: OTHER
First posted: 2022-04-01
Enrollment: 50
Sex: FEMALE
Minimum age (years): 25
Maximum age (years): 35
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: the purpose of the study will be to to examine the effect of low level laser therapy on pain and function disability in postnatal women with sacroiliac joint pain.

Detailed description: Women are more susceptible to sacroiliac joint pain than men because the physiological changes associated with childbearing (e.g. pregnancy associated with weight gain, exaggerated lumber lordosis, hormone-induced ligamentous laxity and the mechanical trauma associated with childbirth) may result in sacroiliac joint pathology .

Low level laser is effective for treatment of various musculoskeletal pain disorders. It releases local neurotransmitters such as serotonin and endorphins. Additionally, the analgesic effect of LLLT is thought to be related to its anti-inflammatory action. Laser irradiations also relieve pain by alleviating and removing swelling and by increasing oxygenation of the tissues, thus results in reduction of the pain .

Eligibility criteria: Inclusion Criteria:

* Post natal women suffering from sacroiliac joint pain for at least 3 months.
* They should have moderate to severe pain in the sacroiliac joint region (visual analogue scale ≥ 4).
* They should have positive findings in at least three of five provocation sacroiliac joint tests (i.e., Patrick's sign, Gaenslen test, compression test, thigh thrust test and distraction test).
* Their age will range from 25 to 40 years old.
* Their Body mass index (BMI) will be ranged from 25 to 30 Kg /m2.
* They should not have any musculoskeletal disorders.

Exclusion Criteria:

* Lumber or hip joint pathology.
* Acute pelvic bacterial or viral infections or tumour.
* Taking nonsteroidal anti-inflammatory drugs, or hormonal treatments.
* Having positive straight leg raising test.

Primary outcomes:
measure: pain intensity
timeFrame: up to 2 months
measure: pain pressure threshold
timeFrame: up to 2 months
Secondary outcomes:
measure: functional disability
timeFrame: up to 2 months
Other outcomes:
Locations:
city: Cairo
country: Egypt
facility: Manal Ahmed
Study officials:
References:
Clinical trial NCT01167036: Effectiveness of a Massage Instrument Compared to Placebo for Upper Trapezius Muscle Pain
Official title: Immediate Effectiveness of Instrument Assisted Soft Tissue Mobilization Compared to Placebo on the Sensitivity of Latent Upper Trapezius Trigger Points: A Randomized Double Blind, Placebo-controlled, Parallel-group Study
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Myofascial Pain Syndrome
Keywords: Myofascial pain syndrome
Trigger points, Myofascial
Chiropractic
Massage
Musculoskeletal manipulation
Lead sponsor: Anglo-European College of Chiropractic
Sponsor class: OTHER
First posted: 2010-07-22
Enrollment: 50
Sex: ALL
Minimum age (years): 18
Maximum age (years): 64
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The purpose of this study was to determine if using a specialized massage tool was more effective than a placebo treatment in relieving pain in the upper trapezius muscle along the top of the shoulder.

Detailed description: The purpose of the study was to determine if a statistically significant and clinically meaningful difference exits between the FascialEdge tool and placebo in the treatment of latent upper trapezius trigger points.

Eligibility criteria: Inclusion Criteria:

* male or female
* between 18-64 years of age
* a latent trigger point of the upper trapezius muscle

Exclusion Criteria:

* an active trigger point of the upper trapezius muscle
* rash or infection of the skin over the trigger point
* neck pain
* taking anticoagulant drugs
* spontaneous bleeding
* long term corticosteroid use

Primary outcomes:
measure: Pressure pain threshold over the upper trapezius muscles as determined with a pressure pain algometer
timeFrame: Within five minutes after initial and only treatment
Secondary outcomes:
Other outcomes:
Locations:
city: Bournemouth
country: United Kingdom
facility: Anglo-European College of Chiropractic
state: Dorset
Study officials:
affiliation: Anglo-European College of Chiropractic
name: Hugh Gemmell, DC, EdD
role: PRINCIPAL_INVESTIGATOR
References: