Clinical trial NCT05825651: Long COVID and Its Associations With Health Outcomes in Older Adults
Official title: A Prospective Cohort Study for Long COVID and Health Outcomes in Older Adults in Yunnan, China
Study type: OBSERVATIONAL
Overall status: ACTIVE_NOT_RECRUITING
Conditions: Long COVID
COVID-19 Pandemic
Elderly Infection
Vaccine Reaction
Lifestyle Factors
Reinfection
Lead sponsor: Peking University
Sponsor class: OTHER
Collaborators: name: National Natural Science Foundation of China
First posted: 2023-04-24
Enrollment: 11527
Sex: ALL
Minimum age (years): 60
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Older adults aged at least 60 years old living in Anning, Yunnan, China

Brief summary: The Peking University Health Cohort in Anning, Yunnan (PKUHC-AN) is a prospective cohort study carried out in Anning, Yunnan. The primary aim of this study is to investigate the impact of COVID-19 on older adults' health, and to provide high-quality evidence of real world research for the optimization of prevention and control strategies of COVID-19 and other emerging infectious diseases. Data will be collected regarding health status, history of COVID-19 infections and vaccines, lifestyle and socioeconomic characteristics, as well as the short- and long-term health outcomes.

Detailed description: COVID-19 pandemic attributed to a great number of mortalities around the world in the last 3 years. About 46% of the global population are estimated to have been infected by the omicron variant and its sublineages. Health outcomes post COVID-19 has been of great concern globally since more and more people infected by SARS-CoV-2. Integrated efforts should be made to estimate the incidence of reinfections and long COVID in China, especially among older adults who are vunlerable and susceptible to COVID-19. In view of this, the Peking University Health Cohort Study in Anning, Yunnan aims to investigate the impact of COVID-19 on older adults' health, and to provide high-quality evidence of real world research for the optimization of prevention and control strategies of COVID-19 and other emerging infectious diseases. Data will be collected regarding health status, history of COVID-19 infections and vaccines, lifestyle and socioeconomic characteristics, as well as the short- and long-term health outcomes.

Eligibility criteria: Inclusion Criteria:

* 1. ≥60 years
* 2. Resided in Anning in the past half year and have no plan to move out in next 1 year
* 3. Older adults who are willing to participate in this study with informed consent

Exclusion Criteria:

* 1. Unable to answer questions or communicate
* 2. Older adults who are not willing to participate in this study or without informed consent

Primary outcomes:
measure: Incidence of long COVID
timeFrame: From baseline until the date of long COVID symptoms or date of death from any cause, whichever came first, assessed up to 12 months.
Secondary outcomes:
measure: Reinfection incidence of COVID-19
timeFrame: At 3 months, 6 months, 9 months, 1 year after baseline investigation.
measure: Cognitive impairment
timeFrame: At 3 months, 6 months, 9 months, 1 year after baseline investigation.
measure: Depression
timeFrame: At 3 months, 6 months, 9 months, 1 year after baseline investigation.
measure: Medical expenditure
timeFrame: At 3 months, 6 months, 9 months, 1 year after baseline investigation.
measure: Incidence of catastrophic health expenditure
timeFrame: At 3 months, 6 months, 9 months, 1 year after baseline investigation.
measure: Sleep quality
timeFrame: At 3 months, 6 months, 9 months, 1 year after baseline investigation.
Other outcomes:
Locations:
city: Kunming
country: China
facility: Anning medical community
state: Yunan
Study officials:
affiliation: Peking University
name: Jue Liu, Ph.D
role: PRINCIPAL_INVESTIGATOR
References: