louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT06166134: Radiological Evaluation of Sarcopenia in Patient Received Chemotherapy
Official title: Radiological Evaluation of Sarcopenia in Patient Received Chemotherapy
Study type: OBSERVATIONAL
Overall status: NOT_YET_RECRUITING
Conditions: Sarcopenia
Lead sponsor: Assiut University
Sponsor class: OTHER
First posted: 2023-12-12
Enrollment: 72
Sex: ALL
Minimum age (years): 18
Maximum age (years): 65
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: OTHER
Time perspective: CROSS_SECTIONAL
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Comparison of muscle mass before and after chemotherapy by use of sonoelastography and computed tomography and comparison with normal volunteer

Brief summary: Radiological evaluation of sarcopenia in patients receiving chemotherapy

Detailed description: Evaluation of muscle mass by using sonoelastography and computed tomography

Eligibility criteria: Inclusion Criteria:

* all cancer patients receiving chemotherapy referred to radiodiagnosis department for routine examination Patients must be between 18 and

Exclusion Criteria:

* Previous or current history of any musculoskeletal or neurological disorder including strokes.
* Systemic atrophy affecting CNS ( Huntington disease ,hereditary ataxia ,spinal muscular disorder and related syndromes ,post polio syndrome )
* Central nervous system demyelinating disease ( Multiple sclerosis , acute disseminated demyelinated syndromes..
* Corticosteroids undertaken currently or for the past 3 years with doses \>5mg/day.

Primary outcomes:
measure: Radiological evaluation of sarcopenia in patients receiving chemotherapy
timeFrame: April 2025
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
affiliation: Assiut university -south egypt cancer institute
name: Lamiaa Refaat, Assisstant professor
role: STUDY_DIRECTOR
affiliation: Assiut university -south egypt cancer institute
name: Omar Mostafa, Assisstant professor
role: STUDY_DIRECTOR
References:
Clinical trial NCT00933634: Efficacy and Safety of Electrical Versus Pharmacological Cardioversion in Early Atrial Fibrillation
Official title: Efficacy and Safety of Electrical Versus Pharmacological Cardioversion in Early Atrial Fibrillation: a Randomized Controlled Trial
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Atrial Fibrillation
Keywords: atrial fibrillation
electrical cardioversion
pharmacological cardioversion
Lead sponsor: Valduce Hospital
Sponsor class: OTHER
First posted: 2009-07-07
Enrollment: 247
Sex: ALL
Minimum age (years): 18
Maximum age (years): 85
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The optimal strategy to restore sinus rhythm in patients with atrial fibrillation (AF) of less than 48 hours' duration is still controversial. The investigators performed a controlled single-center trial to compare electrical and pharmacological (propafenone) cardioversion to restore the sinus rhythm in selected patients with acute atrial fibrillation.


Eligibility criteria: Inclusion Criteria:

* atrial fibrillation of less than 48 hours' duration.

Exclusion Criteria:

* AF of more than 48 hours'
* hemodynamic instability
* acute onset atrial fibrillation due to acute coronary syndrome
* electrolyte disturbances
* sepsis
* fever
* hypothermia
* untreated hyperthyroidism
* use of antiarrhythmic drugs
* high embolic risk
* unclear duration of symptoms

Primary outcomes:
measure: Efficacy of intervention (Electrical and pharmacological cardioversion) in restoring sinus rythm
timeFrame: during emergency department stay
Secondary outcomes:
measure: Number of adverse events related to electrical and pharmacological cardioversion
timeFrame: during emergency department stay
measure: recurrence of atrial fibrillation
timeFrame: within 2 months
Other outcomes:
Locations:
city: Como
country: Italy
facility: Emergency Unit - Valduce Hospital
Study officials:
References:
citation: Bellone A, Etteri M, Vettorello M, Bonetti C, Clerici D, Gini G, Maino C, Mariani M, Natalizi A, Nessi I, Rampoldi A, Colombo L. Cardioversion of acute atrial fibrillation in the emergency department: a prospective randomised trial. Emerg Med J. 2012 Mar;29(3):188-91. doi: 10.1136/emj.2010.109702. Epub 2011 Mar 21.
Clinical trial NCT02372734: Long Term Cognitive Impact of Pediatric Acute Renal Injury
Official title: Long Term Cognitive Impact of Pediatric Acute Renal Injury
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Acute Kidney Injury
Lead sponsor: University of Florida
Sponsor class: OTHER
Collaborators: name: American Society of Nephrology
First posted: 2015-02-26
Enrollment: 73
Sex: ALL
Minimum age (years): 2
Maximum age (years): 36
Standard ages: CHILD
ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: CROSS_SECTIONAL
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Subjects are former patients admitted for sepsis as a child.

Brief summary: The research study will investigate the longitudinal cognitive outcomes in subjects admitted as children diagnosed with sepsis who may have had acute kidney injury. Each subject will be contacted 2-15 years after their incident admission in order to solicit responses to a functional and cognitive quality of life survey. Children admitted during the same time frame that did not have kidney injury will also be surveyed.

Detailed description: 250 subjects with a prior admission for pediatric sepsis will be contacted 2-15 years following the incident admission in order to complete a survey to assess their overall quality of life. Children will be administered the Pediatric Quality of Life (PedsQL) survey with a parental section to allow for parental response. Adult subjects will take the adult version of the PedsQL.

Eligibility criteria: Inclusion Criteria:

* Subjects may be adults or children who were admitted to the hospital with a severe infection between January 1998 to December 2014.
* Consent from adult or parent/guardian of child to participate in study.
* Assent from subjects between 7 and 17 years of age.

Exclusion Criteria:

* Failure or inability to complete the survey
* Participant is unable to understand written or spoken English
* Subjects between 7 and 17 years of age unwilling to assent.

Primary outcomes:
measure: Overall health related quality of life score (HRQOL)
timeFrame: Baseline
Secondary outcomes:
Other outcomes:
Locations:
city: Gainesville
country: United States
facility: UF Health
state: Florida
Study officials:
affiliation: University of Florida
name: Marie-Carmelle Elie, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT06946134: 18-Month Clinical Evaluation of Self-Adhesive Flowable Giomer Compared to Conventional Flowable Giomer in Carious Cervical Lesions: A Randomized Clinical Trial
Official title: 18-Month Clinical Evaluation of Self-Adhesive Flowable Giomer Compared to Conventional Flowable Giomer in Carious Cervical Lesions: A Randomized Clinical Trial
Study type: INTERVENTIONAL
Overall status: NOT_YET_RECRUITING
Phase: NA
Conditions: Cervical Caries
Keywords: Self-adhesive giomer
Bioactive
Randomized clinical trial.
USPHS criteria
Carious cervical lesion
Class V
Clinical performance
FIT SA
Beautifil Flow Plus
Lead sponsor: Cairo University
Sponsor class: OTHER
First posted: 2025-04-27
Enrollment: 34
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The material under investigation will offer the patient a high strength and high durability restoration with the advantage of having anti-bacterial properties.

Detailed description: There is no available evidence for assessing FIT SA restorative material in restoration of cervical lesions. Therefore, this study aims to provide valuable insights into the shear bond strength and clinical performance, in terms of the biological, mechanical and esthetic parameters, of FIT SA restorative material in restoration of cervical lesions.

Eligibility criteria: Inclusion Criteria:

1. Cervical carious lesions in anterior teeth and premolars
2. Small to moderate class V carious lesion (ICDAS 3 \& 4).
3. Vital upper or lower periodontally sound teeth with no signs of irreversible pulpitis.
4. Presence of favorable occlusion and teeth are in normal contact with the adjacent teeth

Exclusion Criteria:

1. Cervical carious lesions in molars.
2. Deep carious defects (close to pulp, less than 1 mm distance).
3. Teeth with clinical symptoms of pulpitis such as spontaneous pain or sensitivity to pressure.
4. Non-vital teeth, Fractured or cracked teeth.
5. Endodontically treated teeth.
6. Periodontally affected teeth

Primary outcomes:
measure: Clinical Performance
timeFrame: 18 months
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
References:
Clinical trial NCT04889534: Predictive Factors for Postoperative Pain, Nausea and Vomiting in Oncological Patients
Official title: Evaluation of Predictive Factors for Nausea, Vomiting and Postoperative Acute Pain in Oncological Patients
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Nausea
Vomiting
Pain, Postoperative
Keywords: nausea
vomiting
pain
Lead sponsor: Instituto do Cancer do Estado de São Paulo
Sponsor class: OTHER
Collaborators: name: Sponsor GmbH
First posted: 2021-05-17
Enrollment: 1500
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: Patients submitted to oncological surgeries in a specialized Hospital

Brief summary: 1809 patients were evaluated in postoperative period. They were asked about nausea, vomiting, retching and pain in the first postoperative 24 hours

Detailed description: Patients were prospectively evaluated , and nausea, vomiting and pain were recorded.

Eligibility criteria: Inclusion Criteria:

* patients submitted to oncological surgeries

Exclusion Criteria:

* refusal to sign the agreement term
* lack of information in the records

Primary outcomes:
measure: Intensity of postoperative pain
timeFrame: 24 hours
Secondary outcomes:
measure: side effects from analgesia
timeFrame: 24 hours
Other outcomes:
Locations:
city: Sao Paulo
country: Brazil
facility: Angela Maria Sousa
state: São Paulo
Study officials:
affiliation: University of Sao Paulo
name: Hazem A Ashmawi, phD
role: STUDY_DIRECTOR
References:
citation: Lee SY, Hung CJ, Chen CC, Wu CC. Survival analysis of postoperative nausea and vomiting in patients receiving patient-controlled epidural analgesia. J Chin Med Assoc. 2014 Nov;77(11):589-93. doi: 10.1016/j.jcma.2014.08.008. Epub 2014 Sep 22.
citation: Gramke HF, de Rijke JM, van Kleef M, Kessels AG, Peters ML, Sommer M, Marcus MA. Predictive factors of postoperative pain after day-case surgery. Clin J Pain. 2009 Jul-Aug;25(6):455-60. doi: 10.1097/AJP.0b013e31819a6e34.
Clinical trial NCT02372617: Hip Reconstruction in Cerebral Palsy With Pelvic Osteotomy
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Cerebral Palsy
Keywords: cerebral palsy
hip
luxation
subluxation
Lead sponsor: Associação de Assistência a Criança Deficiente
Sponsor class: OTHER
First posted: 2015-02-26
Enrollment: 30
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Patients with cerebral palsy of AACD Cerebral Palsy Clinic, with progressive hip subluxation.

Brief summary: Prospective study enrolling patients with cerebral palsy and with subluxation of the hips \> 40% and acetabular dysplasia. The patients will be stratified according the degree of subluxation and age. The treatment protocol is composed by femur variation osteotomy and periacetabular osteotomy. Patients will be divided in two groups according the type of bone graft used at periacetabular osteotomy (autologous or ceramic).


Eligibility criteria: Inclusion Criteria:

* hip subluxation \> 40% and acetabular dysplasia

Exclusion Criteria:

* previous hip surgery

Primary outcomes:
measure: Acetabular index
timeFrame: 12 months
Secondary outcomes:
measure: Reimers Index
timeFrame: 12 months
Other outcomes:
Locations:
city: São Paulo
country: Brazil
facility: AACD
state: SP
Study officials:
References:
Clinical trial NCT00955617: DOTAREM®-Enhanced MRA Compared to GADOVIST®-Enhanced MRA in Patients With Abdominal or Lower Limb Arterial Diseases
Official title: Intra-individual Efficacy Evaluation of DOTAREM®-Enhanced MRA Compared to GADOVIST®-Enhanced MRA in the Diagnosis of Clinically Significant Abdominal or Lower Limb Arterial Diseases
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE4
Conditions: Peripheral Arterial Disease
Keywords: Dotarem
Gadovist
Peripheral arterial disease
MRA
Lead sponsor: Guerbet
Sponsor class: INDUSTRY
First posted: 2009-08-10
Enrollment: 20
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: CROSSOVER
Primary purpose: DIAGNOSTIC

Brief summary: This study is an intra-individual comparison of DOTAREM®-enhanced MRA and GADOVIST®-enhanced MRA in the diagnosis of clinically significant abdominal or lower limb arterial diseases.


Eligibility criteria: Inclusion Criteria:

* Female or male, aged ≥ 18 years
* Patient suffering from Peripheral Arterial Occlusive Disease (PAOD) stage II or III.

Exclusion Criteria:

* Patients with severely impaired renal function with an eGFR (MDRD) \< 50ml/min (eGFR based on recent serum creatinine and MDRD formula - younger than 21 days).
* Patient planned to undergo therapeutic intervention in the vessels of interest between the two MRA procedures.
* Patient who had a major cardiovascular event within 30 days prior to the inclusion.

Primary outcomes:
measure: Overall Image Quality of MRA Images
timeFrame: MRA examination
Secondary outcomes:
measure: Diagnostic Confidence
timeFrame: MRA examination
measure: Signal Intensity
timeFrame: MRA examination
Other outcomes:
Locations:
city: Roissy CDG Cedex
country: France
facility: Guerbet
Study officials:
affiliation: Guerbet
name: Guerbet
role: STUDY_DIRECTOR
References:
Clinical trial NCT02644317: The Balance Influence of Shoe Inserts on Motor Development Delayed Children
Official title: Chung Shan Medical University Hospital Institutional Review Board
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Development Delay
Keywords: Motor development delay
balance
flatfoot
shoe insert
Lead sponsor: Chung Shan Medical University
Sponsor class: OTHER
First posted: 2015-12-31
Enrollment: 100
Sex: ALL
Minimum age (years): 36
Maximum age (years): 83
Standard ages: CHILD
Accepts healthy volunteers: no
Allocation: NON_RANDOMIZED
Intervention model: PARALLEL
Primary purpose: DIAGNOSTIC

Brief summary: Flatfoot, one of the most common foot problems experienced by preschool-aged children, characterized by the collapse of the foot's medial longitudinal arch. Children with motor developmental delay often have flatfoot, according to clinical observation, and research indicates that preschool age is the main stage of the medial longitudinal arch development period. There flatfoot symptoms due to poor arch shock effect, poor walking endurance, likely to cause gait problems while growing up. The lack of a stable foot structure to support and maintain posture may lead to delayed motor development. Early training intervention and help to balance stability is the main rehabilitation goal for motor developmental delayed children. With understanding of the foot development of motor development delayed children, proper intervention can be provided to improve the movement and stability of the lower limbs. The possible deformation of the foot structure and resultant pain in the future can also be prevented.

Detailed description: The investigators designed a prospective cohort study to long-time follow up of preschool aged children with delayed motor development and to establish standard data, including the foot shape, footprint and balance development. The investigators also discuss the influence of the shoe insert with balance and flatfoot correction. Flatfoot leads to poor gross motor balance and the balance improvement after flatfoot correction has never been studied. The investigators findings should provide direct evidence as a reference for clinical workers.

Eligibility criteria: Inclusion Criteria:

* preschool aged children with delayed motor development

Exclusion Criteria:

1. lower limb injury case in six months.
2. other neurological history such as cerebral palsy, traumatic brain injury, spina bifida to cause of developmental delay.
3. have been or are receiving insoles correction or treatment.
4. can not be completed with the instruction by foot measurement and balance measurement.

Primary outcomes:
measure: The balance change of Movement ABC-2 scales
timeFrame: baseline/immediately/12 weeks/1 year/2 year
Secondary outcomes:
measure: The change of foot print parameters
timeFrame: baseline/12 weeks/1 year/2 year
Other outcomes:
Locations:
city: Taichung
country: Taiwan
facility: Chung Shan Medical University Hospital
Study officials:
affiliation: School of Physical Therapy, Chung Shan Medical University
name: Kun-Chung Chen, Ph.D.
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT01460017: Comparison Between Deep Sclerectomy and Traditional Trabeculotomy & Trabeculectomy in Congenital Glaucoma
Official title: Comparison Between The Outcome of Deep Sclerectomy and Traditional Trabeculotomy and Trabeculectomy Surgeries in Congenital Glaucoma
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: PHASE1
Conditions: Congenital Glaucoma
Lead sponsor: King Saud University
Sponsor class: OTHER
First posted: 2011-10-26
Enrollment: 40
Sex: ALL
Minimum age (years): 1
Maximum age (years): 12
Standard ages: CHILD
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The investigators hypothesize that deep sclerectomy in congenital glaucoma is a safer procedure and may yield better results than trabeculotomy trabeculectomy approach.

Detailed description: Non penetrating glaucoma surgery depends on filtration through trabeculo-descmeto window as well as supra-choroidal space less to sub-conjunctival rout. the nature of the operation keeps the globe intact without penetration that leads to less complications compared to penetrating trabeculectomy combined with trabeculotomy.

Eligibility criteria: Inclusion Criteria:

* Any case diagnosed as congenital glaucoma with enlarged corneal diameter more than 11 mm and intra-ocular pressure above 21 mmHg, including corneal edema or Habb's Stria with or without optic disc cupping.
* Any case diagnosed as primary or secondary congenital glaucoma to ocular or systemic abnormalities.
* Within the age of (0 - 12).

Exclusion Criteria:

* Cases of congenital glaucoma with previous intervention.
* Age above 12 Yrs.
* Cases with secondary glaucoma caused by surgical intervention, ocular co-morbidity, medications or trauma

Primary outcomes:
measure: reduction in IOP
timeFrame: 6 month
Secondary outcomes:
Other outcomes:
Locations:
city: Riyadh
country: Saudi Arabia
facility: King Abdul Aziz University Hospital
Study officials:
affiliation: King Saud University
name: Saleh A. Al-Obeidan, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT00556517: Acute Hamstring Strains in Danish Elite Soccer - Diagnosis and Biomechanical Tests
Official title: Acute Hamstring Strains in Danish Elite Soccer - Diagnosis and Biomechanical Tests
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Strains
Keywords: Hamstring
Strain
Rehabilitation
muscles
Lead sponsor: Amager Hospital
Sponsor class: OTHER
First posted: 2007-11-12
Enrollment: 100
Sex: MALE
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: CASE_ONLY
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Male soccer players playing in one of the top 4 divisions in Denmark in the 2007/08 season.

Brief summary: A common soft tissue injury in sports involving sprinting and jumping is the hamstring strain. In addition to the frequency of injury, hamstring injuries are also the most recurrent soft tissue injury occurring in sport. There is a need for further research concerning diagnosis and different prognostic parameters for the rehabilitating process.

The aims for this study are:

A longitudinal comparison of sonographic and MRI assessments of acute and healing hamstring injuries.

A study investigating different biomechanical parameters in the process of determining whether a former hamstring injured soccer player is fully rehabilitated. We hypothesize that it is possible to use electromyography, muscle strength measurements and different tests on a force platform to help determine this issue.


Eligibility criteria: Inclusion Criteria:

* Acute hamstring strain caused during soccer activities (match or training)

Exclusion Criteria:

* A hamstring strain at the time for inclusion

Primary outcomes:
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
affiliation: Department of Orthopaedic Surgery, Amager University Hospital, Denmark
name: Jesper Petersen, MD
role: PRINCIPAL_INVESTIGATOR
References:
citation: Petersen J, Holmich P. Evidence based prevention of hamstring injuries in sport. Br J Sports Med. 2005 Jun;39(6):319-23. doi: 10.1136/bjsm.2005.018549.