Clinical trial NCT07027059: Neural Mobilization Exercises on Pain and Central Sensitization
Official title: The Effect of Neural Mobilization Exercises on Pain and Central Sensitization in Individuals With Lateral Epicondylitis: A Randomized Controlled Trial
Study type: INTERVENTIONAL
Overall status: RECRUITING
Phase: NA
Conditions: Lateral Epicondylitis
Keywords: lateral Epicondylitis
Lead sponsor: Izmir Katip Celebi University
Sponsor class: OTHER
First posted: 2025-06-18
Enrollment: 30
Sex: ALL
Minimum age (years): 18
Maximum age (years): 65
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: Our study aims to investigate the effects of neural mobilization exercises on central sensitization and pain characteristics in individuals with lateral epicondylitis. Enrolled participants will be randomly assigned to two groups. One group will receive routine exercises and ESWT treatment, while the other group will receive neural mobilization exercises in addition to routine exercises and ESWT treatment.

Detailed description: Our study aims to investigate the effects of neural mobilization exercises on central sensitization and pain characteristics in individuals with lateral epicondylitis. Enrolled participants will be randomly assigned to two groups. One group will receive routine exercises and ESWT treatment, while the other group will receive neural mobilization exercises in addition to routine exercises and ESWT treatment.

Median nerve mobilizations will be implemented as the neural mobilization exercises. All groups will receive two sessions per week and complete the process in four weeks; therefore, they will have received eight sessions by the end of the study. Routine exercises and median nerve mobilizations will be implemented in every session, while ESWT will be implemented once a week.

Median nerve mobilizations will be administered in 5 sets, each consisting of 10 repetitions per session.

Before and after the sessions, subjective factors related to pain will be assessed using the Central Sensitization Scale and Pain Catastrophizing Scale, as well as pressure pain threshold.

Eligibility criteria: Inclusion Criteria:

* Clinical diagnosis of lateral epicondylitis
* 18-65 years old

Exclusion Criteria:

Any other pathology, disease, condition, pain, surgery on the elbow, wrist, fingers, shoulder, or neck in the last year

Primary outcomes:
measure: Central Sensitization
timeFrame: baseline and after the 8 sessions (4th week)
Secondary outcomes:
measure: Central Sensitization
timeFrame: baseline and after the 8 sessions (4th week)
measure: Pain Catastrophizing
timeFrame: baseline and after the 8 sessions (4th week)
Other outcomes:
Locations:
city: Izmir
country: Turkey
facility: Izmir Katip Celebi University
Study officials:
affiliation: Izmir Katip Celebi University
name: kevser sevik kacmaz, pt, phd
role: PRINCIPAL_INVESTIGATOR
References:
citation: Coombes BK, Bisset L, Vicenzino B. Management of Lateral Elbow Tendinopathy: One Size Does Not Fit All. J Orthop Sports Phys Ther. 2015 Nov;45(11):938-49. doi: 10.2519/jospt.2015.5841. Epub 2015 Sep 17.