louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT03464747: Continuous Central Venous Lactate Monitoring by Intravascular Microdialysis : a Comparison to Sequential Arterial Lactate Measurement During Shock.
Official title: Continuous Central Venous Lactate Monitoring by Intravascular Microdialysis : a Comparison to Sequential Arterial Lactate Measurement During Shock.
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Shock
Keywords: Lactic Acid
Lead sponsor: Centre Hospitalier Universitaire de Nīmes
Sponsor class: OTHER
First posted: 2018-03-14
Enrollment: 29
Sex: ALL
Minimum age (years): 18
Maximum age (years): 99
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: ICU patients

Brief summary: During shock, arterial hypotension, inadequate cardiac output and microcirculatory alterations lead to tissue hypoxia, multiple organ failure and death. Arterial lactate is considered as the best marker of tissue hypoxia. A lactate decrease during the first 6 hour is strongly associated with better outcome and may be used as a target for assessing the efficiency of shock resuscitation.

The EIRUS system (Maquet Critical Care AB, 17154, Solna, Sweden) is a new device allowing the continuous measurement of venous lactate through a central venous catheter.

However, before being used extensively, such device needs to be evaluated concerning its accuracy. The aim of the present study is to assess the reliability of this device.


Eligibility criteria: Inclusion Criteria:

Acute circulatory failure defined as : systolic blood pressure\<90mmHg or mean arterial pressure \<65mmHg and blood lactate \> 2mmol/L

Exclusion Criteria: Pregnant women

Primary outcomes:
measure: Agreement
timeFrame: Every 4hours for 48hours
Secondary outcomes:
measure: Interchangeability
timeFrame: Every 4hours for 48hours
Other outcomes:
Locations:
city: Nîmes Cedex 9
country: France
facility: CHU de Nîmes - Hôpital Universitaire Carémeau
Study officials:
References:
Clinical trial NCT06852547: The Effect of Ingesting a Novel Algae Protein Source on Rested and Exercised Muscle Protein Synthesis Rates in Older Adults.
Official title: Ingestion of a Novel Algae Protein Source on Rested and Post Exercise Muscle Protein Synthesis Rates.
Study type: INTERVENTIONAL
Overall status: RECRUITING
Phase: NA
Conditions: Nutritional Intervention
Keywords: novel protein
protein synthesis
older adults
alge
Lead sponsor: University of Exeter
Sponsor class: OTHER
First posted: 2025-02-28
Enrollment: 15
Sex: ALL
Minimum age (years): 65
Maximum age (years): 80
Standard ages: OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: CROSSOVER
Primary purpose: OTHER

Brief summary: To assess the rested and postexercise muscle protein synthetic response following the ingestion of a flavourless algae protein source compared with whey protein in older adults.


Eligibility criteria: Inclusion Criteria:

Males and Females BMI 18.5 - 30 kg/m2 Aged 65-80 years Recreationally Active

Exclusion Criteria:

Body mass index (BMI) \<18.5 or \>30 kg/m2 Any metabolic impairments Any cardiovascular impairments High blood pressure (≥140/90 mmHg) Any gastrointestinal disorders Any medications known to affect protein and/or amino acid metabolism A personal or family history of epilepsy, seizures or schizophrenia, motor disorder Chronic over the counter use of pharmaceuticals (\> 1 month) Allergic to any of the whole foods included in the study

Primary outcomes:
measure: Postprandial muscle protein synthesis
timeFrame: 4 hours
Secondary outcomes:
Other outcomes:
Locations:
city: Exeter
country: United Kingdom
facility: Health and Life Sciences
Study officials:
References:
Clinical trial NCT01482247: L-Arginine, Vascular Response and Mechanisms
Official title: L-Arginine, Vascular Response and Mechanisms
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE2
Conditions: Hypertension
Diabetes
Lead sponsor: Brigham and Women's Hospital
Sponsor class: OTHER
First posted: 2011-11-30
Enrollment: 25
Sex: ALL
Minimum age (years): 70
Standard ages: OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: CROSSOVER
Primary purpose: PREVENTION

Brief summary: The purpose of the study is to employ the supplement L-arginine to test the hypothesis that activation of blood flow to the brain during cognitive tasks is regulated by nitric oxide in older subjects with diabetes mellitus and/or hypertension (high blood pressure).


Eligibility criteria: Inclusion Criteria:

* diabetes and/or hypertension

Exclusion Criteria:

* alzheimers disease, dementia, stroke, active herpes, recent angina or heart attack

Primary outcomes:
measure: Functional transcranial doppler measures
timeFrame: 6 weeks
Secondary outcomes:
measure: Flow Mediated Dilation (FMD)
timeFrame: 6 weeks
measure: Finger Blood Flow - Plethysmography (PAT)
timeFrame: 6 weeks
Other outcomes:
Locations:
city: Boston
country: United States
facility: Brigham and Women's Hospital
state: Massachusetts
Study officials:
affiliation: Brigham and Women's Hospital
name: Naomi Fisher, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT02206347: The Effect of Prioritization of Attentional Allocation on Postural-suprapostural Tasking
Official title: The Effect of Prioritization of Attentional Allocation on Postural-suprapostural Tasking
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Attention on Posture
Attention on Supraposture
Lead sponsor: National Taiwan University Hospital
Sponsor class: OTHER
First posted: 2014-08-01
Enrollment: 60
Sex: ALL
Minimum age (years): 20
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: NA
Intervention model: SINGLE_GROUP

Brief summary: Postural-suprapostural task is defined as postural control takes place while at least one other concurrent task is being performed, and appropriate locus of attentional allocation is considered a critical factor for successful postural-suprapostural execution. Recent studies have indicated that the behavior performance of postural-suprapostural task would be affected by the prioritization of attentional allocation (postural-first vs. suprapostural-first); however, the inference of the appropriateness of attention prioritization is primarily limited to behavior observations and lacks direct neural evidences. How the effect of attentional priority between postural and suprapostural tasks on postural-suprapostural performance and its underlying cortical mechanism is rarely understood. By adopting postural-first and suprapostural-first strategies for postural-suprapostural task, the purpose of this 2-year research project is to 1) investigate the differences in performance quality and intrinsic neural mechanisms effect of a postural-suprapostural task for healthy adults with the analysis of event-related potential (ERP) and non-linear dynamics of behavior measures; 2) investigate brain plastic changes and the appropriateness of strategy use. In the first year, the attention prioritization effect on reciprocity of a postural-suprapostural task will be characterized by integrating the results of behavior performance and ERP causal connectivity with a special focus on validation of prevailing theoretical models. In the second year, the difference of task fluent for learning a postural-suprapostural task with postural-first/suprapostural-first strategy will be studied through the spatial and time variations in alpha rhythm after principle component analysis. The present project is expected to have significant contributions not only to gain a better insight to neural correlates of concurrent postural and motor suprapostural tasks, but to optimize treatment strategy for patients with balance or multi-tasking disturbances.


Eligibility criteria: Inclusion Criteria:

* healthy adults without neuromuscular / cardiovascular disease

Exclusion Criteria:

* pregnant women

Primary outcomes:
measure: precision-grip force error
timeFrame: up to 2 years
measure: balance
timeFrame: up to 2 years
Secondary outcomes:
Other outcomes:
Locations:
city: Taipei
country: Taiwan
facility: National Taiwan University
Study officials:
References:
Clinical trial NCT01259947: Lippia Alba for Migraine Prophylaxis and Treatment
Official title: Chemical Composition and Therapeutic Effects of Lippia Alba (Mill.) N. E. Brown Leaves Ethanolic Extract in Patients With Migraine
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE2
Conditions: Migraine Disorders
Keywords: headache
migraine
medicinal plant
essential oil
phytotherapy
Lead sponsor: Casa Espirita Terra de Ismael
Sponsor class: OTHER
First posted: 2010-12-15
Enrollment: 60
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: TREATMENT

Brief summary: Abstract Background: There is no universally accepted and effective prophylaxis of migraine headache episodes. Thus the investigators aimed to investigate the effects of Lippia alba (Mill.) N. E. Brown, an herb with many effects on central nervous system, on pain frequency and intensity of migraine patients.

Methods: Patients were enrolled in a prospective, phase 2, non-controlled cohort study to orally receive ethanolic extract of L. alba leaves (1-2 drips/kg/day). Headache intensity and frequency of episodes were recorded before and after 30-60 days of treatment. The investigators also studied the chemical composition of its essential oil by gas chromatography-mass spectrometry.

Results: The investigators described for the first time a particular L. alba chemotype with geranial and carvenone as major compounds. With treatment, both frequency and intensity of pain episodes significantly decreased from baseline to first reassessment date. More than 80% of patients experienced a minimum 50% reduction on pain intensity and frequency. No side effects were reported.

Conclusions: Treatment with a geranial plus carvenone chemotype of L. alba ethanolic extract is a cheap, widely available, highly effective therapy to reduce both the intensity and the frequency of headache episodes of migraine patients with no side effects.

Keywords: headache, migraine, medicinal plant, essential oil, phytotherapy


Eligibility criteria: Inclusion Criteria:

* Migraine diagnostic

Exclusion Criteria:

* Patient's request

Primary outcomes:
Secondary outcomes:
Other outcomes:
Locations:
city: Araxa
country: Brazil
facility: Naturoterapia Sinho Mariano
state: MG
Study officials:
affiliation: Reserva EcoCerrado Brasil
name: Raul Conde, MD
role: PRINCIPAL_INVESTIGATOR
affiliation: Casa Espirita Terra de Ismael
name: Ana MS Pereira, PhD
role: STUDY_CHAIR
References:
citation: Carmona F, Angelucci MA, Sales DS, Chiaratti TM, Honorato FB, Bianchi RV, Pereira AM. Lippia alba (Mill.) N. E. Brown hydroethanolic extract of the leaves is effective in the treatment of migraine in women. Phytomedicine. 2013 Jul 15;20(10):947-50. doi: 10.1016/j.phymed.2013.03.017. Epub 2013 Apr 30.
citation: Conde R, Correa VS, Carmona F, Contini SH, Pereira AM. Chemical composition and therapeutic effects of Lippia alba (Mill.) N. E. Brown leaves hydro-alcoholic extract in patients with migraine. Phytomedicine. 2011 Nov 15;18(14):1197-201. doi: 10.1016/j.phymed.2011.06.016. Epub 2011 Jul 29.
Clinical trial NCT01807247: Short Effects of a Rehabilitation Session on Gait in Patients With CNS
Official title: Evaluation of the Short Effects of a Rehabilitation Session on Gait Parameters in Patients With a Lesion of the Central Nervous System
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Spastic Gait
Fall Due to Failure of Support
Fatigue
Keywords: Strengthening muscle
Central nervous system diseases
Gait
Lead sponsor: Centre d'Investigation Clinique et Technologique 805
Sponsor class: OTHER
First posted: 2013-03-08
Enrollment: 60
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: The population includes patients with various lesions of central nervous system such as post-stroke patients with hemiparesis, patients with spinal cord injury and patients with mutiple sclerosis.

Brief summary: The aim of the study is to evaluate the short effects of a two rehabilitation session commonly performed in physical therapy,

1. muscle strengthening of the lower limbs and
2. effort reconditioning with cyclo ergometer, on gait characteristics (kinematics, kinetics and electromyographic) in patients with central nervous system lesion.


Eligibility criteria: Inclusion Criteria:

* Male or female adults aged ≥ 18 years receiving a motor rehabilitation in the service
* Hemiplegia after stroke or paraplegia incomplete ASIA C or D or multiple sclerosis (EPSS \<5).
* Walking with or without technical assistance
* Patients who received and signed information and informed consent
* Patient who received physiotherapy session for rehabilitation of the lower limbs
* Patients able to perform the entire study

Exclusion Criteria:

* Patient with safety measure
* Pregnant women, breastfeeding
* Patient who has received botulinum toxin injection of in the lower limbs between 3 weeks and 2 months prior to inclusion in the study
* Bilateral Brain damage, cerebellar syndrome, apraxia, severe aphasia
* Orthopedic complications preventing walking
* Patients who participated in a clinical study within 3 months prior to inclusion • No affiliation to a social security scheme (beneficiary or assignee)

Primary outcomes:
measure: Evaluation of functional capacity after rehabilitation session using functional tests such as 6 minutes walking test and timed up and go
timeFrame: 30 min
Secondary outcomes:
measure: Evaluation of gait pattern and muscle activation patterns during video and EMG analyzes.
timeFrame: 1 hour
Other outcomes:
Locations:
city: Garches
country: France
facility: Hopital Raymond Poincare
Study officials:
affiliation: Hôpital RAYMOND POINCARE
name: Nicolas ROCHE, MDPHD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT01912547: Thromboelastography During Surgery for Malignant Pleural Mesothelioma
Official title: Thromboelastography During Surgery for Malignant Pleural Mesothelioma
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Coagulopathy
Mesothelioma
Lead sponsor: Brigham and Women's Hospital
Sponsor class: OTHER
First posted: 2013-07-31
Enrollment: 100
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Adult patients undergoing surgery for malignant pleural mesothelioma

Brief summary: Surgery for malignant pleural mesothelioma is complex and prolonged, and may involve significant blood loss with considerable blood and product transfusion. Thromboelastography (TEG) is a global assay of coagulation that uses whole blood to produce a tracing that records kinetic changes in clot formation. This study aims provide a better understanding of the coagulation profile of these patients, and will form the basis of a TEG-based transfusion algorithm for future surgeries for mesothelioma.

Detailed description: Thromboelastography can provide more in-depth and quicker analysis of the complex coagulation processes during surgery

Eligibility criteria: Inclusion Criteria:

* Adult male or female patients undergoing elective surgery for malignant pleural mesothelioma

Exclusion Criteria:

* Unwilling or unable to provide consent
* History of bleeding disorder
* On medications that may affect hemostasis

Primary outcomes:
measure: Coagulation profile during extrapleural pneumonectomy or pleurectomy
timeFrame: Surgical period (4-6 hours)
Secondary outcomes:
Other outcomes:
Locations:
city: Boston
country: United States
facility: Brigham and Women's Hospital
state: Massachusetts
Study officials:
affiliation: BWH
name: Ju-Mei Ng, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT04418947: Project Resurgence Communication Trial
Official title: Comparison of the Effectiveness of Communication Strategies on the Return to In-Person Visits to a Medical Center After the Emergence of COVID-19: A Randomized Trial
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Communication Research
Lead sponsor: University of Pennsylvania
Sponsor class: OTHER
First posted: 2020-06-05
Enrollment: 11120
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: FACTORIAL
Intervention model description: Randomized, double-blind, factorial design
Primary purpose: OTHER

Brief summary: Randomized, double-blind, of standard of care vs additional communication and factorial design of intervention letter vs. control letter and EHR vs mail delivery mechanism in patients who canceled visits and did not reschedule over a 90 day period starting March 9, 2020.


Eligibility criteria: Inclusion Criteria:

* Patients with a cancellation or failure to show for a procedure or visit from March 9, 2020 through June 7, 2020 (90 days) and who have not rescheduled as of the date of randomization

Exclusion Criteria:

* Death

Primary outcomes:
measure: Percent of Participants With Visit or Procedure With Provider
timeFrame: 1 month
Secondary outcomes:
measure: Percent of Participants With Scheduled Visit or Procedure With Provider
timeFrame: 1 month
measure: Percent of Participants With Completed Telemedicine Visit With Provider
timeFrame: 1 month
Other outcomes:
Locations:
city: Philadelphia
country: United States
facility: University of Pennsylvania
state: Pennsylvania
Study officials:
References:
citation: Cappola AR, Schriver ER, Mowery DL, Wollack C, Ives CT, Gonzales R, Cappella JN. Effect of Targeted Messaging on Return to In-Person Visits During the COVID-19 Pandemic: A Randomized Clinical Trial. JAMA Netw Open. 2021 Jun 1;4(6):e2115211. doi: 10.1001/jamanetworkopen.2021.15211.
Clinical trial NCT06071247: Application and Translational Research of 3D Printed in Treatment of Choledocholithiasis Under ERCP
Official title: Application and Translational Research of 3D Printed Models in the Surgical Treatment of Common Bile Duct Stones Under Endoscopic Retrograde Cholangiopancreatography
Study type: INTERVENTIONAL
Overall status: NOT_YET_RECRUITING
Phase: NA
Conditions: Common Bile Duct Calculi
Keywords: Common Bile Duct Calculi ;ERCP ;3D printed models
Lead sponsor: Guangdong Second Provincial General Hospital
Sponsor class: OTHER
First posted: 2023-10-06
Enrollment: 60
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The goal of this clinical trial is to learn about Application and translational research of 3D printed models in the surgical treatment of common bile duct stones under endoscopic retrograde cholangiopancreatography. The main question it aims to answer are:Compare the differences in stone removal time, surgical complications, and surgical success rate during ERCP (+EST) surgery between 30 patients who used 3D printing preoperative simulation and 30 patients who did not use it.

Participating patients will be divided into two groups, one group of 30 patients will use 3D printed models for preoperative simulation planning and then undergo surgery, and the other group will undergo surgery directly without using 3D printed models.


Eligibility criteria: Inclusion Criteria:

* Patients with multiple or single common bile duct stones (total stone diameter ≤1.5 cm)
* Patients who voluntarily participated in the study and signed the consent form

Exclusion Criteria:

* Patients with various underlying diseases, such as diabetes, coronary heart disease, and hypertension, that would increase the risk of surgery and affect the outcome of surgery
* Patients who have had cholangiojejunostomy or Roux-en-Y anastomosis
* Combined with intrahepatic bile duct stones require surgical treatment

Primary outcomes:
measure: operation time
timeFrame: intraoperatively
measure: Surgery success rate
timeFrame: intraoperatively
measure: amount of bleeding
timeFrame: intraoperatively
measure: complications
timeFrame: Within 3 days to 1 month after surgery
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
affiliation: Guangdong Second Provincial General Hospital
name: Xiaofeng Li
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT04502147: How to Provide Vascular Control of Splenic Artery Aneurysm? Report of Two Cases
Official title: How to Provide Vascular Control of Splenic Artery Aneurysm? Report of Two Cases
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Arterial Splenic Aneurysm
Lead sponsor: Tecnologico de Monterrey
Sponsor class: OTHER
First posted: 2020-08-06
Enrollment: 1
Sex: MALE
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: CASE_ONLY
Time perspective: RETROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: 41-year-old patient who was diagnosed with splenic artery enlargement on a routine ultrasound examination.

Brief summary: Spleen artery aneurysm represents the most common visceral aneurysm and the third most common splanchnic aneurysm. Most patients have no symptoms and are diagnosed as a part of other diagnostic focuses and examinations. The investigators present two patients with splenic artery aneurysms localized in the splenic hilum, who auspiciously undergo laparoscopic splenectomies with hem-o-lock clips in the vascular hilum without complications. These two cases showed that in addition to the numerous advantages of minimally invasive approaches, there is the possibility to improve laparoscopic technique in terms of safety and economic reasons by using hem - o - lock clips as a hemostatic technique securing the vascular elements of the splenic hilum.


Eligibility criteria: Inclusion Criteria:

Adults patients (\>18 year old) with splenic arterial aneurysms

Exclusion Criteria:

Patients younger than 18 years old. Patients without splenic arterial aneurysms

Primary outcomes:
measure: Arterial Splenic Aneurysm
timeFrame: July 2020
Secondary outcomes:
Other outcomes:
Locations:
city: Monterrey.
country: Mexico
facility: Tecnologico de Monterrey
state: Nuevo Leon
Study officials:
References: