Clinical trial NCT03161977: The Effect of Mannitol on the Serum Potassium During Craniotomy
Official title: The Effect of Mannitol on Intraoperative Serum Potassium in Patients Undergoing Craniotomy：an Observational Study
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Mannitol Adverse Reaction
Hyperkalemia
Lead sponsor: The Affiliated Hospital of Xuzhou Medical University
Sponsor class: OTHER
First posted: 2017-05-22
Enrollment: 30
Sex: ALL
Minimum age (years): 18
Maximum age (years): 70
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: CASE_ONLY
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: patients who are received craniotomy

Brief summary: This is an observational study designed to research the effect of mannitol on the concentration of intraoperative serum potassium in patients undergoing craniotomy, and to guide the safe use of mannitol during craniotomy.

Detailed description: Patients were assigned to receive 20% mannitol (1g/kg) solution administered intravenously 15-20 minutes at the time of drilling skull.The serum potassium was measured by arterial blood gas analysis before infusion (T0), infusion finished (T1), 15min (T2), 30min (T3), 60min (T4) and 120min (T5) after infusion.

Eligibility criteria: Inclusion Criteria:

* age 18 to 70
* American Society of Anesthesiologists physical status I to II
* liver and kidney function is normal
* preoperative concentration of serum potassium was from 3.5 to 5.5 mmol/L

Exclusion Criteria:

* history or presence of congestive heart failure (New York Heart Association class III to IV)
* history or presence of renal failure(diabetes insipidus, or syndrome of inappropriate antidiuretic hormone secretion)
* intraoperative blood transfusion

Primary outcomes:
measure: the concentration of serum potassium
timeFrame: two hours within infusioning mannitol
Secondary outcomes:
Other outcomes:
Locations:
city: Xuzhou
country: China
facility: The Affiliated Hospital of Xuzhou Medical University
state: Jiangsu
Study officials:
References:
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