Clinical trial NCT02002299: Does Surface Tell us About the Invasive Front in Colorectal Cancer
Official title: Prospective Study of Colorectal Cancer Comparing the Surface With the Invasive Front
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Colorectal Cancer
Keywords: colorectal cancer
surface
invasive front
tumor budding
Lead sponsor: Zealand University Hospital
Sponsor class: OTHER
First posted: 2013-12-05
Enrollment: 150
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: CASE_ONLY
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: All patients from Roskilde Hopsital with colorectal cancer who is having surgical resection of the tumor

Brief summary: The purpose of this study is to investigate the invasive front in growth mode (expanding or infiltrative) and dedifferentiation (tumor budding) and comparing these with the tumor surface (polypose or flat) + / - ulceration in surgical specimens at colorectal cancer.

Detailed description: Timetable: From 1 August 2013 to 31 July 2014.

Organisational arrangements: The project is deleted from the pathology department, Roskilde Hospital, and surgical department, Roskilde Hospital.

inclusion criteria All colorectal surgical specimens having cancer were the patient did not receive neoadjuvant treatment received in the pathology department in accordance with current guidelines with the cutting of the tumor area in parallel slices and photographed, so there is macroscopic photo documentation.

Microscopic tumors classified as adenocarcinoma of glandular type, mucinous adenocarcinoma, signet ring cell carcinoma.

When the specimens is received at the department of pathology and is included in the study the pathologist report is registered in a local database.

Eligibility criteria: Inclusion Criteria:

* All surgical preparations from patients with colorectal cancer that did not receive neoadjuvant treatment received in the pathology department in accordance with current guidelines with the cutting of the tumor area in parallel slices and photographed, so there is macroscopic photo documentation.

Microscopic tumors classified as adenocarcinoma of glandular type, mucinous adenocarcinoma, signet ring cell carcinoma.

Exclusion Criteria:

* All surgical preparations from patients with colorectal cancer where the patient received neoadjuvant therapy or when surgery preparation could not be received by current guidelines and all preparations where it is not possible to obtain macroscopic image of the parallel slices.

Microscopic tumors that can not be classified as adenocarcinoma of the glandular type, mucinous adenocarcinoma or signet ring cell carcinoma excluded.

Primary outcomes:
measure: invasive front growth pattern
timeFrame: The histopathological study for one specimens takes one week at average, results will be published shortly after july 2014 (one year after start)
Secondary outcomes:
Other outcomes:
Locations:
city: Roskilde
country: Denmark
facility: Department of Pathology,
Study officials:
affiliation: Department of Pathology, Roskilde Hospital, Denmark
name: Susanne Eiholm, MD
role: PRINCIPAL_INVESTIGATOR
References: