louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT01948999: Electroconvulsive Therapy for Treatment Refractory Schizophrenia - A Randomized, Double-blinded, Sham-controlled Study
Official title: Electroconvulsive Therapy for Treatment Refractory Schizophrenia - A Randomized, Double-blinded, Sham-controlled Study
Study type: INTERVENTIONAL
Overall status: TERMINATED
Phase: NA
Conditions: Treatment-refractory Schizophrenia
Keywords: electroconvulsive therapy
treatment-refractory schizophrenia
Lead sponsor: University of Aarhus
Sponsor class: OTHER
First posted: 2013-09-24
Enrollment: 3
Sex: ALL
Minimum age (years): 18
Maximum age (years): 65
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The purpose of the study is to determine whether addition of electroconvulsive therapy to antipsychotic treatment improves the mental health of patients with treatment-resistant schizophrenia.

Detailed description: The purpose of the study is not achieved.

Eligibility criteria: Inclusion Criteria:

* An ICD-10 schizophrenia diagnosis F20.0-20.3 or F20.9
* PANSS total score \>= 70
* CGI-S \>= 4 (Clinical Global Impression)
* PANSS score \>= 4 on minimum 2 og the following items: Delusions, Conceptual disorganization,Hallucinatory behavior, Excitement, Grandiosity, Suspiciousness, Hostility, Disorientation.
* Previous/current treated with clozapine or refused clozapine treatment
* Lack of response to at least three different antipsychotics
* New antipsychotic medication prescribed more than 8 weeks before inclusion
* Fixed dosage of antipsychotics 1 month before inclusion
* No chance of additional neurotropic 4 weeks before inclusion
* Signed informed consent and power of attorney

Exclusion Criteria:

* Significant substance abuse
* Somatic disease that increases the risk of complications of ECT/anesthesia
* Epilepsy
* For women: Pregnancy or breast-feeding
* Homelessness
* Use of benzodiazepines (apart from tbl. oxazepam 10 mg., max 30 mg. daily)
* Use of antiepileptic
* Previous no effect on psychotic symptoms after ECT treatment (minimum 15 ECT- treatments)
* Concrete suicidal plans

Primary outcomes:
measure: Reduction in total PANSS score and adverse events
timeFrame: The primary outcome will be assessed at screening, baseline and after every second week up to 72 weeks depending on the process for the individaul participant.
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
References:
Clinical trial NCT02860299: Biological and Clinical Measurements Following Systemic Leakage When a Citrate or Heparin Lock is Used
Official title: Evaluation of Systemic Leakage When a Heparin or Citrate Lock is Injected and Biological and Clinical Repercussions: Ancillary Study of the VERROU-REA Randomized Controlled Trial
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE4
Conditions: Acute Renal Insufficiency
Keywords: patients
Lead sponsor: Centre Hospitalier Universitaire Dijon
Sponsor class: OTHER
First posted: 2016-08-09
Enrollment: 76
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL

Brief summary: In the VERROUREA study, there were two cases of an abnormal increase in TCA. In theory no leakage of the lock into the bloodstream should have been seen. Lock leakage could have particularly serious, and especially clinical, repercussions in these patients who already have a high risk of haemorrhage given the numerous associated comorbidities. The aim of this study is to investigate the leakage of locks into the bloodstream by measuring, before and after injection of the lock, the evolution of haemostasis tests and calcaemia. The findings will complete safety data already collected in the VERROU REA study.


Eligibility criteria: Inclusion Criteria:

* Patient aged \> 18 years
* Requiring dialysis for acute kidney failure
* In whom a first non-tunnelled catheter has been inserted
* In the jugular or femoral position
* Once informed consent has been obtained from the patient, a family member or a person of trust

Exclusion Criteria:

* Patients with active and poorly-controlled bleeding
* Known allergy to citrate
* Liver failure (Factor V \<30%)
* Thrombopenia \< 30 000/mm3 in the absence of planned corrective measures at the time of randomization
* Known or suspected heparin-induced thrombopenia
* Positive blood cultures without treatment or with inappropriate treatment at the time of randomization
* Catheter inserted in the subclavian position
* Person without national health insurance cover
* Pregnant women
* Adults under guardianship

Primary outcomes:
measure: Level of calcaemia
timeFrame: through study completion an average of 28 days
measure: Level of haemostasis
timeFrame: through study completion an average of 28 days
Secondary outcomes:
Other outcomes:
Locations:
city: Dijon
country: France
facility: CHU Dijon Bourgogne
Study officials:
References:
Clinical trial NCT03347799: WINROP Algorithm Validation for Retinopathy Screening in a Cohort of Premature Infants
Official title: WINROP Algorithm Validation for Retinopathy Screening in Premature Infants: a Retrospective Cohort Analysis Over 4 Years
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Retinopathy of Prematurity
Keywords: very premature infants
screening
retinopathy
Lead sponsor: Central Hospital, Nancy, France
Sponsor class: OTHER
First posted: 2017-11-20
Enrollment: 570
Sex: ALL
Minimum age (years): 24
Maximum age (years): 40
Standard ages: CHILD
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: RETROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: All infants, born from July 2012 to July 2016, from 24 to 32 weeks gestation had hospitalized in our level III NICU having had eye examination up to 40 weeks post menstrual age.

Brief summary: When a child was born too early, it is more likely to develop an alteration of its visual function than in the case of term birth. Significant visual disturbances are found in 3% of children born prematurely, but visual impairment can be very severe, up to the loss of vision in case of retinopathy of prematurity (ROP) in the most immature infants. The introduction of screening surveillance systems, such as WINROP software, might reduce the need for stressful eye examination in low risk neonates. This retrospective study aimed at validating the WINROP algorithm in a cohort of premature infants, born below 32 weeks of gestation, who had systematic eye examination for ROP screening over 4 year period.


Eligibility criteria: Inclusion Criteria:

* All infants born below 32 weeks gestation within the study period
* At least one eye examination recorded by Retcam

Exclusion Criteria:

* Any ophthalmic abnormality
* Any genetic abnormality

Primary outcomes:
measure: algorithm validation
timeFrame: from birth up to 40 weeks post menstrual age
Secondary outcomes:
measure: risk factor for retinopathy
timeFrame: from birth up to 40 weeks post menstrual age
Other outcomes:
Locations:
Study officials:
References:
Clinical trial NCT05312099: The Effect of Menopause on Sexual Life and Depression: a Case-control Study.
Official title: The Effect of Menopause on Sexual Life and Depression: a Case-control Study.
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Menopause
Depression
Sexual Dysfunction
Lead sponsor: Hitit University
Sponsor class: OTHER
First posted: 2022-04-05
Enrollment: 3
Sex: FEMALE
Minimum age (years): 45
Maximum age (years): 65
Standard ages: ADULT
OLDER_ADULT
Observational model: CASE_CONTROL
Time perspective: CROSS_SECTIONAL
Sampling method: PROBABILITY_SAMPLE
Study population: Çorum Hitit University Erol Olçok Training and Research Hospital Obstetrics and Gynecology Policlinic was composed of 200 married women between the ages of 45-65, 113 of them in the postmenopausal period and 87 of them did not go through menopause.

Brief summary: work completed but not yet published

Detailed description: work completed but not yet published

Eligibility criteria: Inclusion Criteria:

* Case group: Women between the ages of 45-65, who are in the postmenopausal period, who are literate, who do not have communication difficulties / mental disabilities, and who volunteer to participate in the study were included.

Control Group: Women between the ages of 45-55, who were not menopausal, who were literate, who had no communication difficulties / mental disabilities and who volunteered to participate in the study were included.

Exclusion Criteria:

* For case group: Women with premature menopause (before the age of 40), chronic systemic disease (diabetes, heart disease, hypertension, thyroid, rheumatic disease, psychiatric disease history) and using psychiatric drugs were not included in the study.

For control group: Women under the age of 45, over the age of 55 with chronic systemic diseases (diabetes, heart disease, hypertension, thyroid, rheumatic disease, psychiatric disease history) and using psychiatric drugs were not included in the study.

Primary outcomes:
measure: The effect of menopause on sexual life and depression: a case-control study.
timeFrame: 14.01.2019-16.02.2021
Secondary outcomes:
Other outcomes:
Locations:
city: Corum
country: Turkey
facility: Hitit university
Study officials:
affiliation: Fatma
name: Fatma Yıldırım
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT06215599: Attitude Change Of Hearing Health Professionals On Bone-Anchored Hearing Devices Over Time In a Developing Country
Official title: Attitude Change Of Hearing Health Professionals On Bone-Anchored Hearing Devices Over Time In a Developing Country
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Hearing Loss
Bone Anchored Hearing Aids
Lead sponsor: Pamukkale University
Sponsor class: OTHER
First posted: 2024-01-22
Enrollment: 243
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: CROSS_SECTIONAL
Sampling method: NON_PROBABILITY_SAMPLE
Study population: the questionnaire was distributed to participants during relevant congresses of both groups. Consequently, participation was secured from nearly all regions of the country, representing medical institutions at different levels.

Brief summary: This study aims to examine shifts in attitudes about bone-anchored hearing instruments (BAHIs) among hearing health professionals over a period of time.

Detailed description: A survey was designed to assess the knowledge and attitude of participants concerning BAHIs. The survey was administered in both 2019 and 2023 at various conferences, with the questionnaires placed on chairs in different rooms. Responses were collected from Otorhinolaryngologists and audiologists for analysis.

Eligibility criteria: Inclusion Criteria:

Working as a licensed health professional as a medical doctor or an audiologist -

Exclusion Criteria:

None

-

Primary outcomes:
measure: Knowledge about BAHI's
timeFrame: Between-2019-2023
Secondary outcomes:
Other outcomes:
Locations:
city: Denizli
country: Turkey
facility: Pamukkale University
Study officials:
affiliation: Pamukkale University
name: Fazıl N Ardıç, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT04057599: Ileus After Lumbar Spine Surgery
Official title: Investigation of Postoperative Ileus After Lumbar Spine Surgery: a Prospective Observational Study
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Lumbar Spine Surgery Postoperative Ileus
Keywords: post-operative ileus,lumbar spine surgery
Lead sponsor: National Taiwan University Hospital
Sponsor class: OTHER
First posted: 2019-08-15
Enrollment: 156
Sex: ALL
Minimum age (years): 20
Maximum age (years): 90
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: CASE_ONLY
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Patients who undergoing elective lumbar spine surgery

Brief summary: Postoperative ileus (POI) after lumbar spine surgery is not uncommon. However, the incidence, severity and risk factors of ileus after spine surgery remain uncertain because there is not yet a prospective investigation using a subjective grading evaluation tool.

Detailed description: This study aims to prospectively investigate the incidence of POI after spine surgery by using the I-FEED scoring system. The severity of POI after spine surgery thus could be stratified and then an investigation of possible risk factors could be identified.

Eligibility criteria: Adult patients who undergoing elective lumbar spine surgery

Primary outcomes:
measure: Validation of the I-FEED scoring system
timeFrame: 3 days
Secondary outcomes:
Other outcomes:
Locations:
city: Taipei
country: Taiwan
facility: National Taiwan University Hospital
Study officials:
affiliation: National Taiwan University Hospital
name: Fon-Yih Tsuang, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT04977999: Effects of Combining Eccentric and Aquatic Based Exercise on Muscle Function
Official title: Comparative Effects of Eccentric-driven Exercise on Measures of Muscle Function When Combined With Aquatic Plyometric Exercise
Study type: INTERVENTIONAL
Overall status: TERMINATED
Phase: NA
Conditions: Hydrotherapy
Keywords: plyometrics
vertical jump
depth jump
muscle strength
muscle power
eccentric training
Lead sponsor: Utah State University
Sponsor class: OTHER
First posted: 2021-07-27
Enrollment: 35
Sex: ALL
Minimum age (years): 18
Maximum age (years): 30
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Intervention model description: Randomized parallel two group design.
Primary purpose: BASIC_SCIENCE

Brief summary: The study will compare the effects of eccentric resistance training versus eccentric training combined with aquatic plyometric training on muscle function outcomes.

Detailed description: This study will use a parallel, randomized group design. Two groups will be randomly formed with one group comprising an eccentric only resistance training condition (experimental control) and the other comprising an eccentric combined with aquatic-based plyometrics condition (experimental). All subjects, regardless of group, will train on a multiple-joint eccentric machine one time per week for 7 weeks. The combined group will also perform an aquatic-based exercise session one time (on a separate day from the eccentric training) per week. Muscle function will be assessed via a battery of tests including jumps, sprints, and isometric and eccentric maximal strength.

Eligibility criteria: Inclusion Criteria:

* 18 - 30 years

Exclusion Criteria:

* Currently doing resistance exercise \> 3 times per month or aerobic exercise at or more than 30 min, 5 days per week.
* Any lower limb injuries or surgery within a year of the study
* If any of the subject's are too tall for the Eccentron machine (\>76 inches tall)
* If any of the subject's eccentric strength is measured to be greater than 725 pounds during the first test of eccentric strength.

Primary outcomes:
measure: Countermovement jump
timeFrame: 7 weeks
measure: Depth jump
timeFrame: 7 weeks
measure: Maximal isometric strength
timeFrame: 7 weeks
measure: Maximal eccentric strength
timeFrame: 7 weeks
measure: 40-m sprint
timeFrame: 7 weeks
Secondary outcomes:
measure: Muscle soreness
timeFrame: 7 weeks
measure: Muscle soreness (visual analog scale)
timeFrame: 7 weeks
measure: Inertial measurement unit
timeFrame: 7 weeks
Other outcomes:
Locations:
city: Logan
country: United States
facility: Utah State University
state: Utah
Study officials:
affiliation: Utah State Univeristy
name: Brennan J Thompson, PhD
role: STUDY_CHAIR
References:
Clinical trial NCT05572918: Developing a Simple Test to Diagnose Overactive Bladder
Official title: Translation of a Novel Overactive Bladder 'Fingerprint' Into a Breakthrough Non-invasive Diagnostic Test for Use in a Point of Care Setting
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Overactive Bladder
Overactive Bladder Syndrome
Detrusor Overactivity
Lead sponsor: Teesside University
Sponsor class: OTHER
Collaborators: name: South Tees Hospitals NHS Foundation Trust
First posted: 2022-10-10
Enrollment: 100
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: CASE_ONLY
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Participants will be patients with urinary symptoms referred to Consultant Urological Surgeon Ms Mehwash Nadeem at the James Cook Hospital, Middlesbrough or the Friarage Hospital, Northallerton, to undergo a diagnostic test to characterise bladder function and volume.

Brief summary: In order to develop a test to diagnose overactive bladder from urine, it is essential that this test is at least as accurate as the tools that clinicians currently use. As such, this study will compare the performance of the device in development to the performance of existing methods.


Eligibility criteria: Inclusion Criteria:

* The participant is willing and able to give informed consent for participation in the study
* The participant has been diagnosed with over-active bladder
* Aged 18 years or above
* Male or Female

Exclusion Criteria:

* The participant is unwilling to give informed consent for participation in the study
* The participant is unable to represent their own interests or is particularly susceptible to coercion (i.e. is deemed as vulnerable)
* The participant has been diagnosed with neurologic disease (stroke, MS, Parkinson's disease, spinal cord injury); history of uterine, cervical, vaginal or urethral cancer; history of cyclophosphamide use or any type of chemical cystitis; history of benign or malignant bladder tumours; has had Botulinum injections, neuromodulation or augmentation cystoplasty
* Aged 17 years or younger.

Primary outcomes:
measure: Assessment of accuracy of a diagnostic test for overactive bladder
timeFrame: December 2022 - November 2023
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
References:
Clinical trial NCT05098418: Trends of Acute Intoxication in Poison Control Centre
Official title: Trends of Acute Intoxication in Poison Control Centre, Ain Shams University Hospitals From 2015-2019
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Poison Drug
Poison;Medicinal;Wrong Drug
Poisoning
Keywords: food poisoning
insecticides
detergents
heavy metals
Lead sponsor: MTI University
Sponsor class: OTHER
Collaborators: name: Ain Shams University
First posted: 2021-10-28
Enrollment: 10000
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: ECOLOGIC_OR_COMMUNITY
Time perspective: RETROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: all medical records for patients admitted to PCC-ASUH emergency departmentwith the diagnosis of acute intoxication from 2015 to 2019. patients include male and female patients in any age

Brief summary: the study aim to investigate the trend of poisoning and its causative agents among different egyption people ages between 2015 and 2019

Detailed description: This study aim to report different types of intoxication, the significant ages that intend to accidently ingest poisons or commit suicide, and the most commonly used chemicals in toxication, showing different rautes of administration between the years 2015 and 2019

Eligibility criteria: Inclusion Criteria:

- all medical records for patients admitted to PCC-ASUH emergency departmentwith the diagnosis of acute intoxication from 2015 t0 2019

Exclusion Criteria:

- any cases of acute intoxication before 2015 or after the end of 2019 cases of chronic intoxications were excluded

Primary outcomes:
measure: investigating different interventions used for all cases of poisoned people form 2015 till 2019
timeFrame: 5 years
Secondary outcomes:
Other outcomes:
Locations:
city: Cairo
country: Egypt
facility: poison control centre Ain shams university hospitals
Study officials:
affiliation: Lecturer of community and occupational medicine, faculty of medicine, Ain shams university
name: Maha Wahdan
role: STUDY_DIRECTOR
References:
Clinical trial NCT06021418: Efficacy and Safety of DKB-119 in Patients in Crow's Feet
Official title: A Single Center, Randomized, Subject and Evaluator Blinded, Split-face, Pivotal Clinical Trial to Evaluate the Efficacy and Safety of DKB-119 in Crow's Feet
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Crow's Feet
Lead sponsor: Dongkook Pharmaceutical Co., Ltd.
Sponsor class: INDUSTRY
First posted: 2023-09-01
Enrollment: 100
Sex: ALL
Minimum age (years): 19
Maximum age (years): 70
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: To prove the non-inferiority of DKB-119 by evaluating the injecting efficacy and safety DKB-119 and control for patients in crow's feet

Detailed description: A single center, randomized, subject and evaluator blinded, split-face, pivotal clinical trial

Eligibility criteria: Inclusion Criteria:

* Those who are over 19 under 70 ages.
* Those who score 2 or more in the LCL severity evaluation.
* Those who have visually symmetrical crow's feet on both sides.
* Etc.

Exclusion Criteria:

* Pregnancy and lactating women.
* Etc.

Primary outcomes:
measure: Crow's feet
timeFrame: 18 weeks
Secondary outcomes:
measure: Crow's feet
timeFrame: 8, 10 weeks
measure: LCL(Lateral Canthal Line) Severity
timeFrame: 8, 10, 18 weeks
measure: GAIS(Global Aesthetic Improvement Scale)
timeFrame: 8, 10, 18 weeks
Other outcomes:
Locations:
city: Seoul
country: Korea, Republic of
facility: Chungang-University Hospital
Study officials:
References: