louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT01454219: Measurement of Glycaemic Responses of Bakery and Confectionery Products
Official title: Measurement of Glycaemic Responses of Bakery and Confectionery Products
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Healthy
Lead sponsor: Clinical Life Sciences Ltd.
Sponsor class: OTHER
Collaborators: name: Fazer
First posted: 2011-10-18
Enrollment: 14
Sex: ALL
Minimum age (years): 18
Maximum age (years): 65
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: SINGLE_GROUP

Brief summary: This study aims to determine the glycemic index, glycemic load and insulin index of eleven Fazer bakery and confectionary products.


Eligibility criteria: Inclusion Criteria:

* voluntarily given written consent for participation in research
* healthy man or women, age between 18 ang 65 years
* regular eating
* Body Mass Index 18,5 - 24,9 kg/m2

Exclusion Criteria:

* diabetes
* gastrointestinal diseases
* hepatic, kidney, pancreas or thyroid disease or disorder
* arthritis
* pregnancy or breast feeding
* smoking
* allergy
* severe diseases
* blood donation

Primary outcomes:
measure: Glycemic index (GI)
Secondary outcomes:
measure: Insulin index (II)
measure: Glycemic load (GL)
Other outcomes:
Locations:
city: Kajaani
country: Finland
facility: Clinical Life Sciences Ltd
Study officials:
name: Päivi Cheney, MD
role: PRINCIPAL_INVESTIGATOR
affiliation: Clinical Life Sciences Ltd.
name: Tiina Suutari, M.Sc.
role: STUDY_DIRECTOR
References:
Clinical trial NCT03183219: Safety and Efficiency of γδ T Cell Against Liver Cancer
Official title: γδ T Cell Immunotherapy for Treatment of Liver Cancer
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE1
PHASE2
Conditions: Liver Cancer
Keywords: Immunotherapy, γδ T Cell, Liver Cancer
Lead sponsor: Fuda Cancer Hospital, Guangzhou
Sponsor class: OTHER
Collaborators: name: Jinan University Guangzhou
First posted: 2017-06-12
Enrollment: 30
Sex: ALL
Minimum age (years): 18
Maximum age (years): 75
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: In this study, effects of γδT cells on human Liver Cancer in combination with tumor reducing surgery, for example, cryosurgery going to be investigated.

Detailed description: A liver tumor will be removed using tumor reducing surgery such as cryosurgery.PBMC of the patient will be separated from peripheral blood. After making them potential cancer killer γδ T Cell and DC-CIK, they will be infused to the patients as an immunotherapy treatment.

NOTE: Originally, our designed proposal was to use autologous PBMCs from cancer patients to ex vivo expand Vγ9Vδ2-T cells, and then perform adoptive transfer therapy. However, PBMCs of majority of cancer patients could not be effectively expanded, including cell number, cell purity and cell function could not meet the requirements of reinfusion. Meanwhile, those patients could not tolerate 100ml of blood drawing for culture every 2 \~ 3 weeks.

Therefore, we submitted new clinical study application to the ethical committee of the Fuda Hospital affiliated with Jinan University (Guangzhou, PR. China) by changing the autologous protocol with the allogeneic protocol. After the allogeneic protocol was approved, we adapted allogeneic cells instead of autologous in our subsequentially clinical study.

Eligibility criteria: Inclusion Criteria:

1. Age: 18-75
2. Karnofsky performance status \>50
3. Diagnosis with Liver Cancer based on histology or the current accepted radiological measures
4. Classification tumor,nodes,metastasis-classification(TNM) stage: Ⅱ,Ⅲ,Ⅳ
5. Will receive cryosurgery, IRE, gd T cells
6. Life expectancy: Greater than 3 months
7. Ability to understand the study protocol and a willingness to sign a written informed consent document

Exclusion Criteria:

1. Patients with other kinds of cancer
2. History of coagulation disorders or anemia
3. Patients with heart disease

Primary outcomes:
measure: Relief degree of tumors
timeFrame: 3 months
measure: Progress free survival（PFS）
timeFrame: 1 year
measure: Overall survival（OS）
timeFrame: 3 years
Secondary outcomes:
Other outcomes:
Locations:
city: Guangzhou
country: China
facility: Biotherapy center in Fuda cancer hospital
state: Guangdong
Study officials:
affiliation: Biological treatment center in Fuda cancer hospital Guangzhou, Guangdong, China, 510000
name: Jibing Chen, PhD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT05230719: Decrease Artery Occlusion by Distal Radial Arterial Cannulation, Observational Study
Official title: Decrease Artery Occlusion by Distal Radial Arterial Cannulation, Observational Study
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Acute Coronary Syndrome
Procedural Complication
Outcome, Fatal
Keywords: Distal Radial Access
Radial Artery Occlusion
Major Adverse Cardiovascular Events
Lead sponsor: Shenzhen People's Hospital
Sponsor class: OTHER
First posted: 2022-02-09
Enrollment: 2000
Sex: ALL
Minimum age (years): 18
Maximum age (years): 85
Standard ages: ADULT
OLDER_ADULT
Observational model: CASE_CONTROL
Time perspective: RETROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: All the patients who received coronary angiography, based on arterial cannulation procedure, were divided into two groups, dTRA and conventional TRA. We conduct this study to illustrate the complication and MACEs of these two kinds of access.

Brief summary: The site of arterial access for coronary angiography and intervention has been the focus of research for decades as it is the source of major complications. Transradial access (TRA) reduces complications among patients undergoing percutaneous coronary procedures but is reported with the complication of radial artery occlusion (RAO) that limits the radial artery for future needs. Distal radial access (dTRA) has recently gained global popularity as an alternative access route for vascular procedures. Among the benefits of dTRA are the low risk of entry site bleeding complications, the low rate of radial artery occlusion, and improved patient and operator comfort. This study aims to reveal the feasibility and safety of dTRA and routine TRA procedures in acute coronary syndrome patients. The primary endpoints are forearm radical occlusion rate and major adverse cardiovascular events (MACEs) in the two groups. Investigators conduct this retrospected analysis to demonstrate the difference of the two procedure of Cannulation.


Eligibility criteria: Inclusion Criteria:

* presence of a pulse in the snuffbox

Exclusion Criteria:

* Absence of pulse
* Ultrasound indication of arterial occlusion or severe calcification
* Severe forearm artery malformation
* Patients with severe liver and renal failure, or abnormal coagulation function
* Established cardiogenic shock
* History of previous coronary artery bypass grafting and radial artery use.
* Raynaud's disease in the medical history

Primary outcomes:
measure: Forearm radical
timeFrame: 2 years
measure: MACEs
timeFrame: 2 years
Secondary outcomes:
Other outcomes:
Locations:
city: Shenzhen
country: China
facility: Shenzhen People's hospital
state: Guangdong
Study officials:
References:
Clinical trial NCT01926119: TMS for CRPS - Pilot Study
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Complex Regional Pain Syndrome (CRPS)
Lead sponsor: Stanford University
Sponsor class: OTHER
First posted: 2013-08-20
Enrollment: 4
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: TREATMENT

Brief summary: The purpose of this pilot study is to test whether Transcranial Magnetic Stimulation (TMS) may alleviate the symptoms of Complex Regional Pain Syndrome (CRPS). The investigators will test various methods of TMS in a small pilot study to investigate what methods may have clinical potential. This is a small pilot study to determine feasibility and signal to potentially inform future trials.


Eligibility criteria: Inclusion Criteria:

1. Age 18 or older
2. Diagnosis of CRPS (complex regional pain syndrome)
3. Average pain level reported on Numerical Rating Scale meets entry criteria
4. Ability to perform the experimental task and procedures.

Exclusion Criteria:

1. MRI contraindication (metal implants or devices, claustrophobia)
2. TMS Contraindication (eg metal implant or devices near the site of stimulation)
3. History of epilepsy
4. History of a psychological or psychiatric disorder that would interfere with study procedures, at the discretion of the researcher.
5. Neurologic illness that would interfere with brain integrity
6. Current medical condition or medication use that would interfere with study procedures or data integrity, at the discretion of the researcher.
7. Currently pregnant or planning to become pregnant.
8. On going legal action or disability claim.

Primary outcomes:
measure: Change in Pain
timeFrame: Baseline to post-TMS day 5
Secondary outcomes:
measure: Change in Motor Function and Coordination
timeFrame: End of 5-day treatment series and at 1-week follow-up relative to baseline
measure: Change in Sensory Perception
timeFrame: End of each treatment session and at 1-week follow-up as compared to baseline
measure: Change in Vasomotor Function
timeFrame: End of each treatment session and at 1-week follow-up as compared to baseline
measure: Change in Sudomotor Function
timeFrame: End of each treatment session and at 1-week follow-up as compared to baseline
measure: Trophic Changes
timeFrame: End of each treatment session and at 1-week follow-up as compared to baseline
measure: Change in Motor Strength and Joint Range of Motion
timeFrame: End of each of the 5 treatment sessions and at 1-week follow-up relative to baseline
Other outcomes:
Locations:
city: Palo Alto
country: United States
facility: Stanford University School of Medicine
state: California
Study officials:
References:
Clinical trial NCT07005219: Efficacy of Apical Preparation With Passive Ultrasonic Irrigation in Reducing Intracanal Bacteria
Official title: Efficacy of Minimal vs. Conventional Apical Preparation With Passive Ultrasonic Irrigation in Reducing Intracanal Bacteria: A Clinical Study
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Periapical Periodontitis
Root Canal Infection
Keywords: apical periodontitis
irrigation activation
apical enlargement
ddPCR
bacterial species
Lead sponsor: Medipol University
Sponsor class: OTHER
First posted: 2025-06-05
Enrollment: 24
Sex: ALL
Minimum age (years): 18
Maximum age (years): 65
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: This study evaluates intracanal bacterial load in molar teeth with chronic apical periodontitis before and after root canal shaping with two different apical enlargement sizes and ultrasonic irrigation activation.

Detailed description: This randomized controlled clinical trial investigated the effect of different apical enlargement sizes and passive ultrasonic irrigation (PUI) on the bacterial load in the mesial roots of mandibular molars diagnosed with chronic apical periodontitis. The study was conducted at Istanbul Medipol University Faculty of Dentistry, Endodontics Clinic, and included 24 patients who required primary root canal treatment and exhibited clinical and radiographic signs of chronic apical periodontitis.

Participants were randomly assigned to two groups (n=12 each). In Group 1, root canal shaping was performed using a One Curve Mini #25/0.4 rotary file. In Group 2, shaping was performed using a One Curve Mini #35/0.4 rotary file. In both groups, passive ultrasonic irrigation was applied using the VDW Ultra device with an IRRI S 21/25 ultrasonic tip. The irrigation protocol consisted of three 20-second cycles using 1 ml of 3% sodium hypochlorite (NaOCl) per cycle. The ultrasonic tip was positioned 2 mm short of the working length without contacting the canal walls.

Bacterial samples were collected from the mesial root canals during the treatment. The bacterial load was quantified using Droplet Digital PCR (ddPCR), a highly sensitive and precise molecular technique that allows absolute quantification of bacterial DNA. This method was chosen because it enables accurate detection of bacterial reduction following the interventions.

Eligibility criteria: Inclusion Criteria

* a non-contributory medical history
* must have an asymptomatic mandibular molar with periapical lesions of\>2.0x2.0 mm around the mesial roots
* must be diagnosed as chronic apical periodontitis

Exclusion Criteria

* Patients with acute clinical symptoms
* Teeth with previous root canal treatment
* non-restorable teeth

Primary outcomes:
measure: Reduction in Bacterial Load
timeFrame: During operation.
Secondary outcomes:
Other outcomes:
Locations:
city: Istanbul
country: Turkey
facility: Istanbul Medipol University
state: Esenler
Study officials:
affiliation: Medipol University
name: Melike Yavuz
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT02178319: Laparoscopic Versus Open Devascularization for Portal Hypertension, a Randomized Controlled Trial
Official title: Randomized Clinical Trial Comparing Laparoscopic and Open Esophagogastric Devascularization and Splenectomy for Portal Hypertension
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Portal Hypertension
Liver Cirrhosis
Keywords: portal hypertension
Randomized clinical trial
laparoscopic
open
Lead sponsor: Second Affiliated Hospital of Xi'an Jiaotong University
Sponsor class: OTHER
First posted: 2014-06-30
Enrollment: 120
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: Many patients with portal hypertension require surgical treatment each year,and Hassab's operation, or esophagogastric devascularization and splenectomy, is an elective procedure. In recent years,laparoscopic esophagogastric devascularization and splenectomy has been used to treat portal hypertension. However, the potential benefits remain to be demonstrated in the context of a randomized trial. In this study, 120 patients will randomize equally receiving laparoscopic or open esophagogastric devascularization and splenectomy. Inclusion criteria included: platelet count \< 50×109/ml, esophageal and gastric varices revealed, agreeing the informed consent. PerioperativeOutcomes are: technical success, blood loose and infusion during the operation, recurrent varicose veins on gastroscopy examination, patterns of reflux on duplex ultrasound examination, complications, platelet and liver function variation, length of hospital stay. Follow-up will last 5 years, and gastroscopy and ultrasonic will perform at 3 months, 1 year, 3 years, and 5 years. Further more, this study was proved by the ethical committee of second hospital of Xi'an jiaotong university.


Eligibility criteria: Inclusion Criteria:

* The cause of portal hypertension was cirrhosis
* Platelet count \< 50×109/ml
* Esophageal and gastric varices revealed
* Agreeing the informed consent.

Exclusion Criteria:

* Thrombosis present in portal vein preoperatively
* Accompany with liver cancer
* Operation procedure is laparoscopy converse to open
* Patients disagree with the study.

Primary outcomes:
measure: recurrence
timeFrame: 5 years
Secondary outcomes:
measure: operation time
timeFrame: 1 day
Other outcomes:
measure: blood loss during surgical procedure
timeFrame: 1 day
measure: blood transfusion during surgical procedure
timeFrame: 1 day
measure: Number of Participants with Serious and Non-Serious Adverse Events
timeFrame: 4 weeks
measure: rebleeding
timeFrame: 1 day
measure: cost of hospitalization
timeFrame: 4 weeks
measure: survival
timeFrame: 5 years
measure: length of hospital stay
timeFrame: 4 weeks
Locations:
city: Xi'an
country: China
facility: Department of General Surgery , Second Afﬁliated Hospita l, Xi'an Jiaotong Universi ty School of Medicine
Study officials:
References:
Clinical trial NCT00462319: ARTIST: ARThrose Intervention STandardisée
Official title: Evaluation of Standardized Management of Knee Arthritis Patients
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE4
Conditions: Knee Osteoarthritis
Lead sponsor: Almirall, SAS
Sponsor class: INDUSTRY
First posted: 2007-04-19
Sex: ALL
Minimum age (years): 45
Maximum age (years): 75
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: ECT

Brief summary: International recommendations (ACR,EULAR) emphasize physical exercise and weight loss for patients suffering from knee osteoarthritis. Nevertheless, number of patients receiving advices for these 2 points still low. This study evaluates the impact of a standardized medical intervention (patient education, weight reduction and physical exercise) in knee osteoarthritis patients.


Eligibility criteria: Inclusion Criteria:

* symptomatic and ambulatory patients
* suffering from knee osteoarthritis (ACR criteria)
* 25\<BMI\<35
* signed informed consent

Exclusion Criteria:

* need to surgery within 6 next months
* co-morbidity

Primary outcomes:
measure: Weight
measure: Physical Exercise in Leisure
Secondary outcomes:
Other outcomes:
Locations:
city: Paris
country: France
Study officials:
affiliation: Hôpital Salengro - Lille, France
name: René Marc FLIPO
role: PRINCIPAL_INVESTIGATOR
References:
citation: Recommendations for the medical management of osteoarthritis of the hip and knee: 2000 update. American College of Rheumatology Subcommittee on Osteoarthritis Guidelines. Arthritis Rheum. 2000 Sep;43(9):1905-15. doi: 10.1002/1529-0131(200009)43:93.0.CO;2-P. No abstract available.
citation: Messier SP, Gutekunst DJ, Davis C, DeVita P. Weight loss reduces knee-joint loads in overweight and obese older adults with knee osteoarthritis. Arthritis Rheum. 2005 Jul;52(7):2026-32. doi: 10.1002/art.21139.
citation: Ravaud P, Flipo RM, Boutron I, Roy C, Mahmoudi A, Giraudeau B, Pham T. ARTIST (osteoarthritis intervention standardized) study of standardised consultation versus usual care for patients with osteoarthritis of the knee in primary care in France: pragmatic randomised controlled trial. BMJ. 2009 Feb 23;338:b421. doi: 10.1136/bmj.b421.
Clinical trial NCT06578819: Doll Therapy for Agitated Elderly Dementia People
Official title: Determination of the Effect of Doll Therapy Applied to Agitated Elderly People With Dementia on the Level of Agitation, Nutrition and Daily Living Activities
Study type: INTERVENTIONAL
Overall status: ACTIVE_NOT_RECRUITING
Phase: NA
Conditions: Dementia
Agitation
Keywords: dementia
doll therapy
nursing
daily activity
nutrition
Lead sponsor: Karadeniz Technical University
Sponsor class: OTHER
First posted: 2024-08-29
Enrollment: 60
Sex: ALL
Minimum age (years): 65
Standard ages: OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Intervention model description: pre-test and post-test case control
Primary purpose: SUPPORTIVE_CARE

Brief summary: This study is designed to determine the effect of doll therapy on the levels of agitation, nutrition, and daily living activities in elderly patients with dementia and agitation.

Detailed description: Elderly patients with agitation and dementia incur significant costs for healthcare services. Additionally, it is known that agitation can impose a burden on caregivers and has the potential to cause harm to the individual and those around them. This study is planned to determine the effect of doll therapy on the levels of agitation, nutrition, and daily living activities in elderly patients with dementia and agitation.

Eligibility criteria: Inclusion Criteria:

* Patients with dementia
* be 65 years of age or older
* having met the DSM-IV standard for dementia diagnosis
* having a moderate dementia diagnosis
* having a severe dementia diagnosis
* having enough manual skills to hold and care for the doll
* visual acuity is sufficient to recognize the doll
* there is no communication problem
* volunteered to participate in the research
* to have the consent of the relatives patients to participate in the research.

Exclusion Criteria:

* having a mild dementia diagnosis
* the presence of systemic disease in the period of acute exacerbation
* who has a psychological disorder
* elderly people who experienced difficulties after two attempts in accepting a baby and forming a relationship
* elderly people who left the doll after a while despite accepting it
* elderly people who stated that dolls have a bad connotation in themselves.

Primary outcomes:
measure: The Edinburgh feeding evaluation in dementia (EdFED) scale (Nutrition)
timeFrame: 12 week
measure: Cohen-Mansfield Agitation Inventory (Agitation)
timeFrame: 12 week
measure: Katz Daily Life Activities Scale (Daily activities)
timeFrame: 12 week
Secondary outcomes:
measure: The Edinburgh feeding evaluation in dementia (EdFED) scale (Nutrition)
timeFrame: 12 week
measure: Cohen-Mansfield Agitation Inventory (Agitation)
timeFrame: 12 week
measure: Katz Daily Life Activities Scale (Daily activities)
timeFrame: 12 week
Other outcomes:
Locations:
city: Kelkit
country: Turkey
facility: Kelkit State Hospital
state: Gumushane
Study officials:
affiliation: Gümüşhane Universıty
name: AYNUR CIN, DR
role: STUDY_DIRECTOR
References: