Clinical trial NCT00001170: Study of the Psychological Development of Children of Parents With and Without Affective Disorders
Official title: Affective Disorders and Affective Development: A Study of Child Rearing and Child Development in Normal Families and Families With Affective Disorders
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Bipolar Disorder
Involutional Depression
Mood Disorder
Keywords: Parental Psychopathology
Child Rearing
Depression
Bipolar Affective Disorders
Manic-Depression
Social-Emotional Development
Cognitive Development
Child Psychopathology
Affective Disorder
Children at Risk
Lead sponsor: National Institutes of Health Clinical Center (CC)
Sponsor class: NIH
First posted: 1999-11-04
Enrollment: 1045
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: yes

Brief summary: This research study is the continuation of a study started more than 20 years ago. The study was designed to explore the effect that depressed parents have on their children and to better understand the factors that contribute to depression development and maintenance.

The study will continue to investigate if children have certain characteristics in early and middle childhood that predict the later development of psychological disorders.

In addition, the study will continue looking at the processes responsible for the development of children of parents with and without affective (mood) disorders.

Detailed description: The psychological development of offspring of parents with and without affective disorder is assessed from early childhood to young adulthood. Parents with a diagnosis of major depression or bipolar illness and well parents and their children are studied (SADS-L, RDC, and SCID, DSM-III). A sibling pair is studied in each family. Parent-child interaction is investigated through direct observation of behavior in naturalistic and controlled settings. Family history information is obtained through parent interviews. Behavioral observations, standard tests, physical examinations, and psychiatric interviews, and MRI procedures provide multiple assessments of the offspring. The study has been completed through preadolescence, adolescence, and late adolescence. Follow-up in young adulthood continues.

Eligibility criteria: Patients will be drawn from an ongoing longitudinal study begun in 1979 of offspring of parents with affective illness (unipolar and bipolar) and children of normal control parents.

Primary outcomes:
Secondary outcomes:
Other outcomes:
Locations:
city: Bethesda
country: United States
facility: National Institute of Mental Health (NIMH)
state: Maryland
Study officials:
References:
citation: Achenbach TM, Edelbrock CS. The Child Behavior Profile: II. Boys aged 12-16 and girls aged 6-11 and 12-16. J Consult Clin Psychol. 1979 Apr;47(2):223-33. doi: 10.1037//0022-006x.47.2.223. No abstract available.
citation: Beardslee WR, Bemporad J, Keller MB, Klerman GL. Children of parents with major affective disorder: a review. Am J Psychiatry. 1983 Jul;140(7):825-32. doi: 10.1176/ajp.140.7.825.
citation: Billings AG, Moos RH. Comparisons of children of depressed and nondepressed parents: a social-environmental perspective. J Abnorm Child Psychol. 1983 Dec;11(4):463-85. doi: 10.1007/BF00917076.
citation: Labella MH, Ruiz SK, Harris SJ, Klimes-Dougan B. Emotion socialization in mothers with mood disorders: Affective modeling and recollected responses to childhood emotion. Dev Psychopathol. 2021 Oct;33(4):1156-1169. doi: 10.1017/S0954579420000395.
citation: Klimes-Dougan B, Long JD, Lee CY, Ronsaville DS, Gold PW, Martinez PE. Continuity and cascade in offspring of bipolar parents: a longitudinal study of externalizing, internalizing, and thought problems. Dev Psychopathol. 2010 Nov;22(4):849-66. doi: 10.1017/S0954579410000507.