Clinical trial NCT04853654: Investigation of the Effects of Selective Exercise Training in Multiple Sclerosis
Official title: Investigation of the Effects of Selective Exercise Training on Muscle Architecture, Balance, Function and Fatigue in Multiple Sclerosis
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Multiple Sclerosis
Exercise
Keywords: multiple sclerosis
muscle architecture
Eccentric Exercise
Concentric Exercise
Lead sponsor: Sanko University
Sponsor class: OTHER
First posted: 2021-04-21
Enrollment: 33
Sex: ALL
Minimum age (years): 18
Maximum age (years): 50
Standard ages: ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: Selective exercise programs specific to muscle groups, with the workload to be done in line with the muscle's own structure, can enable more strength to be released with less fatigue in MS, and this increase in strength can increase balance and functional activities. to determine the effects of type training (selective exercise training), eccentric and concentric training on function, balance, fatigue and muscle architecture.

Detailed description: Recovery and enhancement of muscle function in MS is one of the main goals in physiotherapy and rehabilitation. In literature studies, it is stated that eccentric and concentric exercises are effective exercise approaches in increasing strength and reducing fatigue. However, the best exercise method is not yet clear in terms of providing better performance adaptation with less fatigue. Considering the architectural features of the lower extremity muscles, it is aimed to increase the angle of pennation with programs that include concentric strengthening of the quadriceps, gastro-soleus and gastrocnemius muscles, which are suitable muscle groups to produce large forces by design. With programs that include eccentric strengthening of the hamstring and tibialis anterior muscles that function in a wide range of motion and have high excursion ability, it is aimed to increase fiber length.

Eligibility criteria: Inclusion Criteria:

* Between the ages of 18-50,
* With an Extended Disability Status Scale (EDSS) score of 4 or less,
* No regular exercise habit
* Able to walk on the treadmill,
* No pregnancy,
* Not receiving corticosteroid treatment in the last month,
* Fampridine etc. in the last 1 month. not taking medication,
* Patients who have not received Botox treatment in the last 6 months

Exclusion Criteria:

patients who do not agree to volunteer

Primary outcomes:
measure: muscle architecture parameter 1
timeFrame: Change from Baseline at 8th weeks and 12th weeks
measure: muscle architecture parameter 2
timeFrame: Change from Baseline at 8th weeks and 12th weeks
measure: muscle architecture parameter 3
timeFrame: Change from Baseline at 8th weeks and 12th weeks
measure: Muscle strength
timeFrame: Change from Baseline at 8th weeks and 12th weeks
Secondary outcomes:
measure: walking fatigue
timeFrame: Change from Baseline at 8th weeks and 12th weeks
measure: perceived fatigue
timeFrame: Change from Baseline at 8th weeks and 12th weeks
measure: physical fatigue
timeFrame: Change from Baseline at 8th weeks and 12th weeks
measure: static balance
timeFrame: Change from Baseline at 8th weeks and 12th weeks
measure: dynamic balance
timeFrame: Change from Baseline at 8th weeks and 12th weeks
measure: Functional activities 1
timeFrame: Change from Baseline at 8th weeks and 12th weeks
measure: Functional activities 2
timeFrame: Change from Baseline at 8th weeks and 12th weeks
measure: Functional activities 3
timeFrame: Change from Baseline at 8th weeks and 12th weeks
Other outcomes:
Locations:
city: Gaziantep
country: Turkey
facility: Zekiye İpek Katırcı Kırmacı
Study officials:
affiliation: Hacettepe University
name: TÜZÜN FIRAT
role: STUDY_DIRECTOR
affiliation: Sanko University
name: AYHAN ÖZKUR
role: STUDY_CHAIR
affiliation: Sanko University
name: AYŞE MÜNİFE NEYAL
role: STUDY_CHAIR
affiliation: Dr. Ersin Arslan Training and Research Hospital,
name: ABDURRAHMAN NEYAL
role: STUDY_CHAIR
affiliation: Sanko University
name: NEVİN ERGUN
role: STUDY_DIRECTOR
References: