Clinical trial NCT02563847: Effect of Amino Acids and Sugar Alcohols on Gastric Emptying and Release of Satiation Peptides in Humans
Official title: Effect of Amino Acids and Sugar Alcohols on Gastric Emptying and Release of Satiation Peptides in Normal Weight and Obese Subjects
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Endocrine System Diseases
Lead sponsor: University Hospital, Basel, Switzerland
Sponsor class: OTHER
First posted: 2015-09-30
Enrollment: 20
Sex: ALL
Minimum age (years): 18
Maximum age (years): 40
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: CROSSOVER
Primary purpose: PREVENTION

Brief summary: With this study the investigators investigate the effects of amino acids (tryptophan in two different concentrations, leucin) and sugar alcohols (xylitol, erythritol) on satiety mechanisms.


Eligibility criteria: Inclusion Criteria:

* Healthy normal weight subjects with a body-mass index of 19.0-24.9
* Healthy obese subjects with a body-mass index of \> 30
* Normal eating habits (no diets; no dietary changes; no special dietary habits, such as vegetarian/vegan)
* Age 18-40 years
* Stable body weight for at least three months

Exclusion Criteria:

* Smoking
* Substance abuse
* Regular intake of medications (except for oral contraceptives)
* Medical or psychiatric illness
* History of gastrointestinal disorders
* Food allergies
* Pregnancy, breast feeding

Primary outcomes:
measure: Effect of different aminoacids and sugar alcohols on secretion of satiation hormones
timeFrame: changes from baseline to three hours after treatment
measure: Effect of different aminoacids and sugar alcohols on secretion of satiation hormones
timeFrame: changes from baseline to three hours after treatment
measure: Effect of different aminoacids and sugar alcohols on secretion of satiation hormones
timeFrame: changes from baseline to three hours after treatment
measure: Effect of different aminoacids and sugar alcohols on secretion of satiation hormones
timeFrame: changes from baseline to three hours after treatment
measure: Effect of different aminoacids and sugar alcohols on secretion of satiation hormones
timeFrame: changes from baseline to three hours after treatment
measure: Effect of different aminoacids and sugar alcohols on secretion of satiation hormones
timeFrame: changes from baseline to three hours after treatment
Secondary outcomes:
measure: Effect of different aminoacids and sugar alcohols on gastric emptying
timeFrame: changes from baseline to four hours after treatment
Other outcomes:
Locations:
city: Basel
country: Switzerland
facility: University Hospital Basel, Phase 1 Research Unit
Study officials:
affiliation: University Hospital, Basel, Switzerland
name: Christoph Beglinger, Prof.
role: PRINCIPAL_INVESTIGATOR
References:
citation: Meyer-Gerspach AC, Hafliger S, Meili J, Doody A, Rehfeld JF, Drewe J, Beglinger C, Wolnerhanssen B. Effect of L-Tryptophan and L-Leucine on Gut Hormone Secretion, Appetite Feelings and Gastric Emptying Rates in Lean and Non-Diabetic Obese Participants: A Randomized, Double-Blind, Parallel-Group Trial. PLoS One. 2016 Nov 22;11(11):e0166758. doi: 10.1371/journal.pone.0166758. eCollection 2016.