louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT02969447: Management of Third-stage of Labor After Second Trimester Medical Pregnancy Termination
Official title: Effect of Intra-venous Oxytocin Injection After Fetal Expulsion in Management of Third-stage of Labor After Second Trimester Medical Pregnancy Termination
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE4
Conditions: Retained Placenta
Keywords: Retained Placenta
Second trimester medical termination
Third stage labor
Oxytocin
Lead sponsor: University Hospital, Bordeaux
Sponsor class: OTHER
First posted: 2016-11-21
Enrollment: 27
Sex: FEMALE
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: PREVENTION

Brief summary: Prospective randomized trail which compare 2 regimens for third-stage management after second trimester medical pregnancy termination : 10UI intra venous oxytocin or no additional medication after fetal expulsion. Primary outcome was the incidence of placental retention.

Detailed description: Complication of third stage of labor in second trimester medical pregnancy termination is not well studied. Accord to publications, the placental retention rate is 30 to 40% in these situations. Placental retention may be associated with increased blood loss, increased requirement for blood transfusion anesthetic and operative complications, and infectious morbidity. The high incidence of retained placenta is an area of clinical concern. Publications reveal a wide variation in practices but there are only few studies about third stage of labor in second trimester medical pregnancy termination. The study is a prospective randomized trial. Two third stage management strategies are compared: 10 units of intra venous oxytocin (group 1) and no additional medication (group 2) after fetal expulsion. It concerns pregnancies between 14 and 28 weeks gestation.

Eligibility criteria: Inclusion Criteria:

* 18 years old and older
* medical pregnancy termination between 14 and 28 weeks gestation
* informed consent obtained

Exclusion Criteria:

* less than 18 years old
* refusal to consent
* in utero fetal death

Primary outcomes:
measure: Incidence of placental retention
timeFrame: Up to 30 minutes after fetal expulsion
Secondary outcomes:
measure: Incidence of partial placental retention
timeFrame: Up to 1 hour after fetal expulsion
measure: Incidence of digital exploration
timeFrame: Up to 1 hour after fetal expulsion
measure: Incidence of blunt curettage
timeFrame: Up to 1 hour after fetal expulsion
measure: Incidence of post-partum hemorrhage
timeFrame: Up to 1 hour after fetal expulsion
measure: Blood loss
timeFrame: Up to 1 hour after fetal expulsion
Other outcomes:
Locations:
city: Bordeaux
country: France
facility: CHU de Bordeaux
Study officials:
References:
Clinical trial NCT02468947: Finding Ideal Blood Culture Volume in NICU
Official title: Finding Ideal Blood Culture Volume in NICU
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Ideal Sample Volume for Blood Cultures
Keywords: Neonatal sepsis
Lead sponsor: Shaare Zedek Medical Center
Sponsor class: OTHER
First posted: 2015-06-11
Enrollment: 800
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: All babies treated in the neonatology department of the institution undergoing sepsis workup

Brief summary: The investigators want to assess the effectivity of different sample volumes in blood cultures.

Detailed description: The investigators intend to compare yield of 0.5ml sample x2 vs 0.25 ml samples x2 (aerobic and anaerobic media for each volume) taken from the sample taken from the same site and time.

Time to positivity will also be compared, as well as possible contamination rates.

Eligibility criteria: Inclusion Criteria:

* Suspected sepsis

Exclusion Criteria:

* Need for extra puncture in order to withdraw enough blood for the second set of cultures.
* Urgent need for antibiotic without time for cultures.

Primary outcomes:
measure: Positive blood cultures of each group
timeFrame: 2 years
Secondary outcomes:
measure: Time to positivity for each group
timeFrame: 2 years
measure: Suspected contamination rate
timeFrame: 2 years
Other outcomes:
Locations:
city: Jerusalem
country: Israel
facility: Ruben Bromiker
Study officials:
References:
citation: Yaacobi N, Bar-Meir M, Shchors I, Bromiker R. A prospective controlled trial of the optimal volume for neonatal blood cultures. Pediatr Infect Dis J. 2015 Apr;34(4):351-4. doi: 10.1097/INF.0000000000000594.
Clinical trial NCT00758147: Force Feedback Joystick in Upper Limb Rehabilitation Following Stroke
Official title: Assessment of Force Feedback Joystick in Upper Limb Rehabilitation Following Stroke
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Stroke
Keywords: force feedback joystick
stroke
haptics
kinematics
rehabilitation
robotics
Force feedback joystick in stroke rehabilitation
Lead sponsor: Rabin Medical Center
Sponsor class: OTHER
Collaborators: name: Ono Academic College
First posted: 2008-09-23
Enrollment: 30
Sex: ALL
Minimum age (years): 65
Maximum age (years): 86
Standard ages: OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NON_RANDOMIZED
Intervention model: CROSSOVER
Primary purpose: TREATMENT

Brief summary: The purpose of this study is to assess the influence of force feedback joysticks and haptic feedback in improving upper limb rehabilitation outcomes following stroke.

Detailed description: Upper limb paresis or plegia following stroke remains a significant cause of impairment and disability. Regaining function requires learning through repetitive movements and activities of daily living(ADLs).

The aim of the study in this application is to test the usability of the system in specialized rehabilitation hospital settings. In this first stage of development, after developing and testing the system together with expert physiotherapists, we will examine the system for usability (is it "user friendly"), comfort level, and therapeutic efficacy.

The system consists of an ordinary PC computer, specially written software, and a commercially available force feedback joystick. (Force feedback joysticks, are usually used for gaming; they contain miniature motors that allow the joystick to either help or resist the movements of the person using it). Patients who are unable to grasp the joystick will use a specially built arm rest that is attached to an ordinary office chair without wheels. Patients rest their forearm on the arm rest and thus can manipulate the joystick by means of movement of the shoulder and elbow joints instead of by movements of the wrist, since wrist movements are often difficult for brain damaged individuals.

Eligibility criteria: Inclusion Criteria:

* Medically stable post first stroke patients
* Score of more than 17 on the Mini Mental Scale Test(MMST)

Exclusion Criteria:

* A history of psychiatric illness
* Inability to understand the informed consent form
* Inability to understand and follow 2-3 step instructions
* Receptive aphasia (sensory aphasia)

Primary outcomes:
measure: Fugl Meyer impairment scale
timeFrame: 1 month
measure: Wolf Motor Function Test
timeFrame: One month
Secondary outcomes:
measure: Satisfaction survey about the use of the joystick
timeFrame: 1 Month
Other outcomes:
Locations:
city: Petach Tikva
country: Israel
facility: Beit Rivka Geriatric Hospital
Study officials:
affiliation: Beit Rivka Geriatric Hospital
name: Shai Brill, M.D.
role: PRINCIPAL_INVESTIGATOR
affiliation: Ono Academic College
name: Heidi Sugarman, PhD
role: STUDY_DIRECTOR
References:
Clinical trial NCT06137547: HPI for Prevention of Hypotension During Cardiac Surgery
Official title: Hypotension Prediction Index for Prevention of Hypotension During Cardiac Surgery: A Randomized Controlled Trial
Study type: INTERVENTIONAL
Overall status: RECRUITING
Phase: NA
Conditions: Cardiac Surgery Patients
Keywords: cardiac surgery
hypotension prediction index
hypotension
randomized controlled trial
Lead sponsor: Mackay Memorial Hospital
Sponsor class: OTHER
First posted: 2023-11-18
Enrollment: 110
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: PREVENTION

Brief summary: Hypotension prediction index (HPI) was applied in various types of non-cardiac surgery with convincing benefits of preventing hypotensive events and clinical sequelae. Although HPI was validated in cardiac surgery, its clinical benefits are not proven yet. We aim to evaluate its effects on intraoperative hypotension and postoperative adverse events in cardiac surgery. In this randomized, single-blind trial, we will enroll adults scheduled for elective primary cardiac surgery under general anesthesia. Participants will be randomly assigned to intraoperative HPI-guided or non-HPI-guided hemodynamic management. The primary endpoint is the time-weighted average intraoperative hypotension below a mean arterial pressure threshold of 65 mmHg. The secondary endpoints are postoperative complications.


Eligibility criteria: Inclusion Criteria:

* adult
* elective, primary, isolated coronary arterial bypass surgery (CABG) or isolated valve surgery
* provide inform consent.

Exclusion Criteria:

* arrhythmia (e.g., atrial fibrillation, atrial flutter)
* intracardiac shunts
* preoperative inotropic usage
* preoperative supportive devices usage (e.g., intra-aortic balloon pump, extracorporeal membrane oxygenation, left ventricular assist device, or right ventricular assist device)
* receiving urgent or emergent procedures.

Primary outcomes:
measure: TWA (time-weighted average) of intraoperative hypotension
timeFrame: From induction to the end of surgery. (If cardiopulmonary bypass (CPB) is adopted, the time of CPB will not be counted in)
Secondary outcomes:
measure: incidence of hypotension
timeFrame: from induction to the end of surgery (excluding CPB time)
measure: duration of hypotension
timeFrame: from induction to the end of surgery (excluding CPB time)
measure: postoperative complications
timeFrame: after surgery until discharge, assessed up to 30 days
measure: length of ICU stay
timeFrame: after surgery until ICU discharge, assessed up to 30 days
measure: length of hospital stay
timeFrame: after surgery until hospital discahrge, assessed up to 30 days
Other outcomes:
Locations:
city: Taipei
country: Taiwan
facility: Mackay memorial hospital
Study officials:
References:
Clinical trial NCT01727947: Influence of Sperm With Large Nuclear Vacuole on ICSI Outcomes
Official title: Influence of Sperm With Large Nuclear Vacuoles on the Cycles' Outcomes of Couples Couples Undergoing ICSI
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Pregnancy
Lead sponsor: Sapientiae Institute
Sponsor class: OTHER
First posted: 2012-11-16
Enrollment: 200
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: DIAGNOSTIC

Brief summary: Current research on sperm morphology has been directed towards the dysmorphisms of the sperm head. A new technique based on the motile sperm organelle morphology examination (MSOME) allows the detection of sperm with large nuclear vacuoles (SLV). Large nuclear vacuoles are specific sperm alterations observed under high magnification, and their presence has been related to increased DNA fragmentation and denaturation.

Detailed description: A new method for the detailed morphological evaluation of motile spermatozoa in real time, under high magnification, named "motile sperm organellar morphology examination" (MSOME) was developed. This magnification provides an accurate description of spermatozoa abnormalities, particularly the presence of head vacuoles, which is indicative of abnormal chromatin packaging in spermatozoa. However, the influence of sperm with large nuclear vacuoles (SLV) on ART outcomes is still a matter of debate. The goals for this study were to identify whether there is a connection between SLV under high magnification and ICSI outcomes.

Eligibility criteria: Inclusion Criteria:

* Couples undergoing intracytoplasmic sperm injection (ICSI) as result of male factor or tubal factor or unexplained infertility
* Women with regular menstrual cycles of 25-35 days
* Women with normal basal follicle stimulating hormone (FSH) and luteinizing hormone (LH) levels
* Women with body mass index (BMI) less than 30 kg/m2
* Women with both ovaries and intact uterus

Exclusion Criteria:

* Women with polycystic ovaries syndrome
* Women with endometriosis
* Women with gynaecological/medical disorders
* Couples with any sexually transmitted disease
* Women who had received any hormone therapy for less than 60 days preceding the study

Primary outcomes:
measure: Pregnancy
timeFrame: 1 month
Secondary outcomes:
Other outcomes:
Locations:
city: Sao Paulo
country: Brazil
facility: Sapientiae Institute
state: SP
Study officials:
affiliation: Sapientiae Institute
name: Edson Borges Jr., MD., PhD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT05213247: Effect of Khat Chewing on Blood Pressure and Heart Rate Among Healthy Adults
Official title: A Short-Term Follow-Up Study on the Effect of Khat Chewing on Blood Pressure and Heart Rate Among Healthy Adults in Taiz, Yemen: Its Associated Factors and SDS-Khat
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Blood Pressure
Heart Rate
Keywords: Khat-SDS
Blood Pressure
Heart Rate
Lead sponsor: Aljanad University for Science and Technology
Sponsor class: OTHER
First posted: 2022-01-28
Enrollment: 100
Sex: ALL
Minimum age (years): 15
Maximum age (years): 65
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: CASE_ONLY
Time perspective: CROSS_SECTIONAL
Sampling method: PROBABILITY_SAMPLE
Study population: This is a cross-sectional study conducted from April to September 2021 in Taiz, Yemen. 100 healthy adults were selected using a random sampling method.

Brief summary: This study is a cross sectional study

Detailed description: Objective: This study aims to investigate .ht short-term effect of khat on the diastolic and systolic blood pressure (DBP, SBP) and heart rate (HR) of yemeni adults. Factors associated with Khat chewing and Khat-dependence were also investigated. That the khat chewing is a growing public habit among yemeni people.

Eligibility criteria: The participant should be free of any disease and should avoid eating or drinking anything that could affect on BP and HR within two khat before hours chewing (zero time)

Primary outcomes:
measure: Blood Pressure
timeFrame: April- December 2021
Secondary outcomes:
Other outcomes:
Locations:
city: Ta'izz
country: Yemen
facility: Mujeeb Sultan
Study officials:
affiliation: Aljanad University for Science and Technology
name: Mujeeb Sultan
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT01808547: Comparison Study of ISV-303 to Durasite Vehicle in Cataract Surgery Subjects
Official title: A Randomized Double-Masked Study to Compare the Ocular Safety,Tolerability,and Efficacy of ISV-303 to Durasite Vehicle in Cataract Surgery Subjects
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE3
Conditions: Ocular Inflammation
Lead sponsor: Sun Pharmaceutical Industries Limited
Sponsor class: INDUSTRY
First posted: 2013-03-11
Enrollment: 268
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The purpose of this study is to evaluate the ocular safety, tolerability and efficacy of topical administration of ISV-303 compared with Durasite Vehicle.


Eligibility criteria: Inclusion Criteria:

* Male or female subjects age 18 or older scheduled for unilateral cataract surgery with posterior chamber intraocular lens implantation
* If a female is of childbearing potential, the subject must agree to and submit a negative pregnancy test before any protocol-specific procedures are conducted. The subject must use effective contraception for the duration of the study. Post menopausal is defined as having no menses for at least 12 consecutive months
* Signature of the subject on the Informed Consent Form
* Willing to avoid disallowed medications for the duration of the study
* Willing and able to follow all instructions and attend all study visits
* Able to self-administer the IMP (or have a caregiver available to instill all doses of study drugs )
* Additional inclusion criteria also apply

Exclusion Criteria:

* Known hypersensitivity or poor tolerance to bromfenac sodium or any component of the IMP or any of the procedural medications
* Currently pregnant, nursing, or planning a pregnancy; or be a woman that has a positive pregnancy test
* Currently suffer from alcohol and/or drug abuse
* Prior (within 30 days of beginning study treatment) or anticipated concurrent use of an investigational drug or device
* A condition or a situation, which in the investigator's opinion may put the subject at increased risk, confound study data, or interfere significantly with the subject's study participation
* Additional inclusion criteria also apply

Primary outcomes:
measure: Ocular Inflammation
timeFrame: 15 days
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
References:
Clinical trial NCT06040047: Prediction of Cervical Radiculopathy Success With PNF and Mobilization
Official title: Identifying Patients With Cervical Radiculopathy Responding to Proprioceptive Neuromuscular Facilitation Exercises Combined With Passive Cervical Mobilization: Clinical Prediction Rule
Study type: INTERVENTIONAL
Overall status: RECRUITING
Phase: NA
Conditions: Cervical Radiculopathy
Lead sponsor: Cairo University
Sponsor class: OTHER
First posted: 2023-09-15
Enrollment: 50
Sex: ALL
Minimum age (years): 40
Maximum age (years): 60
Standard ages: ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: DIAGNOSTIC

Brief summary: The goal of this predictive interventional study is todetrmine clinical predictors for success with combined proprioceptive neuromusclualr faciitaion (PNF) and passive mobilization ain patients with cervical radiculopathy (CR).

Detailed description: This study will answer the question, what are the factors affecting success with PNF and mobilization for patients with CR? No control group. The goal of this new study is to see the effect of age, duration of symptoms, forward posture angle and neck disability index response to passive mobilization combined with the PNF technique

Eligibility criteria: Inclusion Criteria:

* Participants with cervical radiculopathy.
* Age ranges between 40 and 60 years old.
* Minimum score (3 out of 10-point) on a visual analog scale (VAS)
* Orthopedic clinical confirmation reveals a history of neck pain.

Exclusion Criteria:

* Whiplash injury.
* Previous Cervical surgery.
* Pain less than three months.
* Mechanical and non-specific neck pain.
* Pregnancy.
* Bilateral arm pain.
* Inflammatory arthritides.
* Osteoporosis.
* Symptoms of vertebrobasilar insufficiency.

Primary outcomes:
measure: Cervical pain
timeFrame: 6 weeks
measure: Cervical disability
timeFrame: 6 weeks
Secondary outcomes:
measure: Cervical proprioception
timeFrame: 6 weeks
Other outcomes:
Locations:
city: Cairo
country: Egypt
facility: ME
Study officials:
affiliation: Cairo University
name: Ahmed ElMelhat, Phd
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT04363047: Immune Cells in Inflammatory Arthritis With Coronaviruses, Including COVID-19
Official title: Immune Cells and the Coronavirus for Inflammatory Arthritis
Study type: OBSERVATIONAL
Overall status: ENROLLING_BY_INVITATION
Conditions: SARS Virus
Lead sponsor: University of Manchester
Sponsor class: OTHER
First posted: 2020-04-27
Enrollment: 125
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Observational model: COHORT
Time perspective: RETROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: People who have previously taken part in (and provided at least 1 set of blood samples to) either the BRAGGSS or National Repository Healthy Volunteer Studies and have given us permission to contact them for future research

Brief summary: A team at the University of Manchester are developing a test that tcould be helpful in detecting immunity to the Coronavirus (which causes the COVID-19 disease) in participants with inflammatory arthritis. It is based on a flu assay has already developed; the team will replace the flu antigen with a Coronavirus antigen to see if it is effective.

This project aims to develop a test to see if people who have had the virus have developed immunity to it. This could help to predict who might or might not get the disease a second time, who should stay at home to be protected from potential infection or who will not develop any symptoms, even if exposed to the virus.

When vaccination trials against the Coronavirus will be launched, this test could also help to see if the vaccine is effective.


Eligibility criteria: Inclusion Criteria:

* Has previously taken part in either the BRAGGSS or National Repository Healthy Volunteer Study
* Has agreed to be contacted abut future research projects
* Has previously provided a blood sample for either the BRAGGSS or National Repository Healthy Volunteer Study
* Is willing to complete the informed consent form, registration slip, questionnaire and provide a 40ml blood sample
* Has a good written understanding of English

Exclusion Criteria:

* Has not previously taken part in either the BRAGGSS or National Repository Healthy Volunteer Study
* Has not agreed to be contacted abut future research projects
* Has not previously provided a blood sample for either the BRAGGSS or National Repository Healthy Volunteer Study
* Is not willing to complete the informed consent form, registration slip, questionnaire and provide a 40ml blood sample
* Has not got a good written understanding of English

Primary outcomes:
measure: Prevalence and abundance of CD4+ T lymphocytes
timeFrame: 2 years
Secondary outcomes:
Other outcomes:
Locations:
city: Manchester
country: United Kingdom
facility: University of Manchester
state: Greater Manchester
Study officials:
References: