louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT02320747: Immediate Effect of Tai Chi Exercise in Healthy Volunteers
Official title: Immediate Effect of Tai Chi Exercise in Healthy Volunteers:Randomized Controlled Study
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Healthy
Keywords: Volunteers
Lead sponsor: Adwin Life Care
Sponsor class: INDUSTRY
Collaborators: name: Shanghai University of Sport
name: Warwick Research Services
First posted: 2014-12-19
Enrollment: 64
Sex: ALL
Minimum age (years): 18
Maximum age (years): 25
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL

Brief summary: Tai Chi has been widely practiced as a Chinese martial art that focuses on slow sequential movements, providing a smooth, continuous and low intensity activity. It has been promoted to improve balance and strength and to reduce falls in the elderly, especially those 'at risk'. The potential benefits in healthy younger age cohorts and for wider aspects of health have received less attention.

The present study documented prospective changes in balance and vascular responses for a community sample of adults.


Eligibility criteria: Inclusion Criteria:

* 18 to 25 years old
* Have given written informed consent
* Have a high school level of education
* Be healthy and psychologically stable as determined by screening for medical and psychiatric problems via a personal interview, a medical questionnaire, a physical examination, an electrocardiogram (ECG), and routine medical blood and urinalysis laboratory tests.
* Have an active interest in exploring and developing their spiritual lives
* Cigarette smokers must agree to abstain from smoking on session days
* Agree to refrain from using any psychoactive drugs, including alcoholic beverages, within 24 hours
* Agree that for one week before each session, refrain from taking any nonprescription medication, nutritional supplement, or herbal supplement except when approved by the study investigators.

Exclusion Criteria:

* Women who are pregnant or nursing
* Cardiovascular conditions: coronary artery disease, stroke, angina, uncontrolled hypertension, a clinically significant ECG abnormality
* Epilepsy with history of seizures
* Insulin-dependent diabetes
* Currently taking psychoactive prescription medication on a regular (e.g., daily) basis

Primary outcomes:
measure: Heart rate (HR)
timeFrame: 40 Minutes
measure: Systolic Pressure (SP)
timeFrame: 40 minutes
measure: Diastolic Pressure (DP)
timeFrame: 40 Minutes
Secondary outcomes:
Other outcomes:
Locations:
city: Jaipur
country: India
facility: GyanSanjeevani
state: Rajasthan
Study officials:
affiliation: Shanghai University of Sport
name: Avinash Mishra, MSc
role: PRINCIPAL_INVESTIGATOR
affiliation: Shanghai University of Sport
name: Dinghai Yu
role: STUDY_DIRECTOR
References:
Clinical trial NCT05314647: Lutein Supplementation in Healthy Children
Official title: Effects of Lutein Supplementation on Cognition and Vision in Healthy Children With Screen Time Exposure: A Randomized Controlled Trial
Study type: INTERVENTIONAL
Overall status: ACTIVE_NOT_RECRUITING
Phase: NA
Conditions: Eye Fatigue
Diet, Healthy
Cognitive Change
Keywords: lutein
carotenoids
blue light
screen time
digital stress
Lead sponsor: Northcentral University
Sponsor class: OTHER
First posted: 2022-04-06
Enrollment: 59
Sex: ALL
Minimum age (years): 8
Maximum age (years): 16
Standard ages: CHILD
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Intervention model description: randomized, double-blind, placebo controlled
Primary purpose: TREATMENT

Brief summary: This is a single site, randomized, double-blind placebo controlled parallel arm study assessing the effects of 6 months lutein supplementation on cognitive and visual outcomes in healthy children exposed to excessive digital screen time.

Detailed description: Studies in humans and primates have also shown that appropriate daily intake of lutein provides protection to the eyes from blue light from screen time devices such as computers, televisions and phones. It has been well-documented that children are spending far over the recommended two hours screen time per day and excessive exposure to the high energy blue light associated with digital devices has been shown to cause both short-term and long-term visual damage as well as disruption to the sleep cycle. With a globally aging population, if this deficit is not addressed adequately early on in life then there will be substantial public health consequences. A recent study predicted that if individuals were to consume the recommended levels of lutein and zeaxanthin daily, there would be a seven percent reduced risk for age related eye disease and a potential savings of over five billion US dollars annually.

Eligibility criteria: Inclusion Criteria:

* Age of 8 to 16 years
* guardian-reported general good health
* guardian-reported 4 hours or more of digital screen time daily

Exclusion Criteria:

* Currently using a supplement containing lutein or zeaxanthin

Primary outcomes:
measure: Macular Pigment Optical Density - heterochromatic flicker photometry
timeFrame: 6 months
measure: Macular Pigment Optical Density - haidinger's brushes
timeFrame: 6 months
Secondary outcomes:
measure: Digital Eye strain change from baseline
timeFrame: 6 months
measure: Sleep score change from baseline
timeFrame: 6 months
measure: Verbal Fluency
timeFrame: 6 months
Other outcomes:
Locations:
city: Des Moines
country: United States
facility: Kemin Industries
state: Iowa
Study officials:
affiliation: Northcentral University
name: Patrick McNamara, PhD
role: STUDY_CHAIR
References:
Clinical trial NCT02882347: The Effect of Somatostatin for Treatment of Post Hepatectomy Liver Failure (PHLF)
Official title: The Effect of Somatostatin for Treatment of Post Hepatectomy Liver Failure (PHLF)
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: PHASE3
Conditions: Liver Failure
Lead sponsor: Korea University Anam Hospital
Sponsor class: OTHER
Collaborators: name: Pharmbio Korea Co., Ltd.
First posted: 2016-08-29
Enrollment: 20
Sex: ALL
Minimum age (years): 18
Maximum age (years): 80
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: TREATMENT

Brief summary: Post hepatectomy liver failure (PHLF) is a serious medical problem could lead to patient death, however, definite treatment strategy has not been established. The liver is a regenerating organ and the possibility of PHLF could be reduced when the appropriate liver regeneration is guaranteed.

Portal flow has known to be important during liver regeneration. Low portal flow cannot induce proper regeneration, contrary, excessive flow increase shear stress in the hepatic sinusoid resulting liver failure.

Various medications has been used in malignant liver cirrhosis to reduce portal pressure. Among them, somatostatin has been used modulating portal flow reducing portal and sinusoidal pressure.

In this study, the investigators administrate somatostatin at a rate of 3.5ug/kg/hour to PHLF patients (prothrombin time \< 50% and serum total bilirubin \> 2.9mg/dl after liver resection) until recovery from liver failure. For assessment of the recovery of liver failure, the investigators evaluate aspartate transaminase (AST), alanine transaminase (ALT), serum total bilirubin and prothrombin time periodically after administration of medication.


Eligibility criteria: Inclusion Criteria:

1. Patients with PHLF without regard primary disease.
2. Ability to provide written informed consent

Exclusion Criteria:

1. Concomitant surgery for another intraabdominal organs.
2. Severe renal disease requiring dialysis.
3. Patients with coagulation disorders or taking warfarin.
4. Immunosuppressed patients or the patients with autoimmune disorders.
5. Women with pregnant, breast-feeding.
6. Hypersensitivity to somatostatin.
7. Patients treated with other investigational product within 30 days at the consents are obtained.
8. Patients with a significantly reduced cognitive abilities.
9. Not eligible to participate for study at the discretion of investigator.

Primary outcomes:
measure: in hospital mortality
timeFrame: up to 4 weeks
Secondary outcomes:
measure: Complication rate
timeFrame: up to 4 weeks
measure: Time to recovery from PHLF (days)
timeFrame: up to 4 weeks
Other outcomes:
Locations:
city: Seoul
country: Korea, Republic of
facility: Korea university Anam hospital
Study officials:
affiliation: Department of surgery, Korea university Anam hospital
name: Dong-Sik Kim, Professor
role: STUDY_CHAIR
References:
Clinical trial NCT06292247: Effectiveness of CBT and APT on Managing Child Anxiety in Dental Office
Official title: Effectiveness of Cognitive Behavioral Therapy and Auricular Plaster Therapy on Managing Child Anxiety in Dental Office
Study type: INTERVENTIONAL
Overall status: ACTIVE_NOT_RECRUITING
Phase: NA
Conditions: Dental Anxiety
Keywords: dental anxiety (DA)
Cognitive behavioral therapy (CBT)
Auricular Plaster Therapy (APT)
Tell Show Do (TSD)
Lead sponsor: Mansoura University
Sponsor class: OTHER
First posted: 2024-03-05
Enrollment: 60
Sex: ALL
Minimum age (years): 4
Maximum age (years): 7
Standard ages: CHILD
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Intervention model description: Group 1 (CBT) Group 2 (APT) Group3 (control TSD)
Primary purpose: OTHER

Brief summary: This study was conducted to the Effectiveness of Cognitive Behavioral Therapy and Auricular Plaster Therapy on Managing Child Anxiety in Dental Office.

Detailed description: This study is to:

1. Assess and compare the effect of cognitive behavioral therapy and auricular plaster therapy on children's anxiety in dental situations.
2. Improve child behavior and cooperation and evaluate the parental acceptance of these behavioral management techniques.

Eligibility criteria: Inclusion Criteria:

1. Healthy children (4-7) years old, without systemic, congenital, or mental disorders nor deformities affecting the external auditory meatus.
2. Presence of dental anxiety.
3. Not requiring urgent dental treatment, with the presence of a Class I carious lesion on one of the primary molars.
4. No previous application of the guided CBT.

Exclusion Criteria:

1. Refusal to participate by either the children or their parents/guardians
2. Previous receiving acupuncture and moxibustion therapy.
3. Children who had taken sedative drugs at the time of the appointment.

Primary outcomes:
measure: Venham Clinical Anxiety Scale
timeFrame: Up to 12 weeks
measure: Heart Rate to detect the anxiety.
timeFrame: Up to 12 weeks
measure: RMS-Self Pictorial scale to detect the anxiety.
timeFrame: Up to 12 weeks
Secondary outcomes:
measure: Parental acceptance of the behavior management technique
timeFrame: Up to 12 weeks
Other outcomes:
Locations:
city: Mansoura
country: Egypt
facility: Faculty of dentistry
state: Dakahlia
Study officials:
affiliation: Mansoura University
name: Reina N Abed, Master
role: PRINCIPAL_INVESTIGATOR
affiliation: Prof. of Pediatric Dentistry and Dental Public Health Faculty of Dentistry Mansoura University
name: Salwa M Awad, Prof
role: STUDY_DIRECTOR
affiliation: Prof. of Pediatric Dentistry and Dental Public Health Faculty of Dentistry Mansoura University
name: Ahmad H Wahba, PhD
role: STUDY_DIRECTOR
References:
Clinical trial NCT00213447: T Cell Response in Hypersensitivity Syndrome
Official title: Characterization of T Cell Response in Hypersensitivity Syndrome
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Hypersensitivity
Syndrome
Lead sponsor: University Hospital, Rouen
Sponsor class: OTHER
First posted: 2005-09-21
Enrollment: 40
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: patients with Drug rash with eosinophilia and systemic symptoms

Brief summary: immunological study of the T cell repertoire phenotype and functionality in hypersensitivity syndrome.


Eligibility criteria: Inclusion Criteria:

* age \> 18
* cutaneous eruption
* lymph nodes
* hepatitis
* interstitial pneumonia
* nephritis
* cardiopathy
* eosinophilia
* hyperlymphocytosis

Exclusion Criteria:

* age minor to 18
* HIV +

Primary outcomes:
Secondary outcomes:
Other outcomes:
Locations:
city: Rouen
country: France
facility: UH-Rouen
Study officials:
affiliation: UH rouen
name: Pascal Joly, MD-PHD
role: PRINCIPAL_INVESTIGATOR
References:
citation: Picard D, Janela B, Descamps V, D'Incan M, Courville P, Jacquot S, Rogez S, Mardivirin L, Moins-Teisserenc H, Toubert A, Benichou J, Joly P, Musette P. Drug reaction with eosinophilia and systemic symptoms (DRESS): a multiorgan antiviral T cell response. Sci Transl Med. 2010 Aug 25;2(46):46ra62. doi: 10.1126/scitranslmed.3001116.
Clinical trial NCT03941847: Evaluation of the Effect of Musical Listening on Hypnotic Savings During the Induction of General Anesthesia
Official title: Musinduc : Impact of Music During the Period of Anaesthetic Induction - a Randomized Controlled Clinical Trial
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Music, Anesthetic, Induction
Lead sponsor: University Hospital, Caen
Sponsor class: OTHER
First posted: 2019-05-08
Enrollment: 104
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Intervention model description: 2 groups will be compared. The experimental group will benefit from musical listening during the induction period of the anesthesia. The control group will have a usual care.
Primary purpose: SUPPORTIVE_CARE

Brief summary: Anesthetic induction requires the use of, among other things, hypnotic drugs that can lead to hemodynamic disorders, postoperative cognitive dysfunctions and delayed awakening. A strategy to reduce the doses of hypnotics administered could improve patients' postoperative outcomes and is part of the current strategy of accelerated postoperative rehabilitation. Music has shown its effectiveness in reducing the doses of hypnotics administered during sedation procedures.

Objective :

We propose a study of this anesthetic period evaluating the effectiveness of music as an adjuvant agent for anesthetic drugs allowing hypnotic savings.

Materials and methods :

Randomized, prospective, monocentric study

2 groups will be compared. The experimental group will benefit from musical listening during the induction period of the anesthesia. The control group will have a usual care.

The primary endpoint is the amount of hypnotic (propofol®) used during anesthesia induction. The main secondary criteria are the duration of induction, the cost of induction, and the postoperative pain score and the proportion of patients with postoperative nausea and vomiting.

This study should include 104 subjects (52 in each group) requiring general anesthesia.

Hypothesis tested:

Listening to music reduces the amount of hypnotic product used in the induction of anesthesia by 0.5 mg/kg.


Eligibility criteria: Inclusion Criteria:

* Patient presenting for surgery under general anesthesia in ophthalmic surgery, ENT, CMF and neurosurgery (lumbar and cervical disc hernia, neurostimulator insertion, vertebral cementoplasty)
* Score ASA 1, 2, 3.
* Intervention time \< 3 hours.

Exclusion Criteria:

* Patients under 18 years of age
* Patient under guardianship or curatorship
* Refusal of the patient
* Deaf patient
* Non-cooperating patient
* Anesthetic protocol different from that standardised

Primary outcomes:
measure: quantity of propofol
timeFrame: 2 months
Secondary outcomes:
measure: Quantity of morphinomimetics
timeFrame: 2 months
Other outcomes:
Locations:
city: Caen
country: France
facility: Uteza
state: Normandy
Study officials:
References:
Clinical trial NCT02540447: Purge Vs no Purge in Living Donor Liver Transplantation Recipients
Official title: Graft Portal Reperfusion Without Purging Graft Preservative Solution In Living Donor Liver Transplantation. A Prospective Randomized Controlled Trial
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Ischemia Reperfusion Injury
Keywords: Liver transplantation
Graft rinse
Ischemia reperfusion injury
Lead sponsor: Mansoura University
Sponsor class: OTHER
First posted: 2015-09-04
Enrollment: 80
Sex: ALL
Minimum age (years): 18
Maximum age (years): 60
Standard ages: ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: PREVENTION

Brief summary: The investigators tested the impact of purging the graft contents and mesenteric blood into the systemic circulation versus washing out this volume out of the circulation in living donor liver transplantation recipients.

Detailed description: All donors had right hepatectomy. On the back table, surgeons flushed liver grafts with 4 Liters of cold Custodiol solution. Patients were randomized into either purge group (Pg) (n=40) were graft fluid contents were washed out by the patient's portal vein blood (0.5ml per gram graft weight) through incompletely anastomosed hepatic vein, or No purge group (NPg) (n=40) where graft fluid contents were washed into the systemic circulation by the patient's portal blood. The primary outcome objective was the mean arterial blood pressure 5 minutes after portal declamping. Secondary objectives included hemodynamic and oxygenation.

Eligibility criteria: Inclusion Criteria:

* Adult living donor liver transplantation recipients of either sex in mansoura liver transplantation program

Exclusion Criteria:

* re-transplantation
* Previous upper abdominal operation
* Budd Chiari syndrome

Primary outcomes:
measure: Lowest 5 Minutes Post-reperfusion Mean Arterial Blood Pressure
timeFrame: 5 minutes post-reperfusion
Secondary outcomes:
measure: Biliary Complications (Participants)
timeFrame: 3 months
measure: Ischemia Reperfusion Injury
timeFrame: 7 days
measure: Post-operative Infectious Complications
timeFrame: 30 days
measure: 3 Months Mortality
timeFrame: 3 Months
Other outcomes:
Locations:
city: Mansoura
country: Egypt
facility: Liver transplantation project - Gastroenterology surgical center - Mansoura university
state: Dakahlia
Study officials:
affiliation: Mansoura Faculty of Medicine
name: Amr M Yassen, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT05319847: An Exploratory Investigation of a Male Focused Skincare Supplement
Official title: An Exploratory Investigation of a Male Focused Skincare Supplement
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Acne
Skin Abnormalities
Lead sponsor: Let's Disco
Sponsor class: INDUSTRY
Collaborators: name: Citruslabs
First posted: 2022-04-08
Enrollment: 38
Sex: MALE
Minimum age (years): 18
Maximum age (years): 55
Standard ages: ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: TREATMENT

Brief summary: Most skincare products on the market are topical and do not take a holistic approach to understanding skin health. This trial will examine a dietary supplement designed to support the gut microbiome and promote skin health from an internal perspective. Research has previously supported the link between the gut microbiome and skin health and the supplement tested in this trial will further the knowledge on the effectiveness of supporting gut health to improve skin outcomes.


Eligibility criteria: Inclusion Criteria:

* Male
* Between the ages of 18-55
* Frequently experience different forms of acne
* Frequently experience breakouts
* Must be in good health with no long term health conditions
* BMI must be under 40
* Must follow a consistent dietary regimen
* Must be willing to stop any oral supplementation targeting their skin while in the trail

Exclusion Criteria:

* Anyone who does take prescription medication (oral or topical) targeting their skin including reinoid, over the counter retinol, or retinal
* Not willing to stop any oral supplementation targeting their skin
* Severe chronic conditions, including oncological and psychiatric disorders
* Previous severe allergic reactions
* Unwilling the follow the study protocol

Primary outcomes:
measure: Adult Acne
timeFrame: 12 week
Secondary outcomes:
Other outcomes:
Locations:
city: Santa Monica
country: United States
facility: Citruslabs
state: California
Study officials:
References:
Clinical trial NCT06830447: Test-retest Reliability of Myocene
Official title: Test-retest Reliability of Low-frequency Fatigue Assessed Using Myocene
Study type: OBSERVATIONAL
Overall status: NOT_YET_RECRUITING
Conditions: Reliability
Fatigue
Lead sponsor: University of Maia
Sponsor class: OTHER
First posted: 2025-02-17
Enrollment: 50
Sex: ALL
Minimum age (years): 18
Maximum age (years): 40
Standard ages: ADULT
Accepts healthy volunteers: yes
Observational model: COHORT
Time perspective: CROSS_SECTIONAL
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Participants will be sports science students, physically active.

Brief summary: The test retest reliability of Myocene will be tested.


Eligibility criteria: Inclusion Criteria:

* active individuals

Exclusion Criteria:

* injured participants
* unhealthy volunteers

Primary outcomes:
measure: low-frequency fatigue
timeFrame: baseline and 30 minutes post baseline.
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
References:
Clinical trial NCT01922947: Motivational Interviewing Integrated With Social Network Counseling for Teens
Official title: Motivational Interviewing Integrated With Social Network Counseling for Teens
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Substance Use
Lead sponsor: Virginia Commonwealth University
Sponsor class: OTHER
Collaborators: name: National Institute on Drug Abuse (NIDA)
First posted: 2013-08-14
Enrollment: 120
Sex: ALL
Minimum age (years): 14
Maximum age (years): 18
Standard ages: CHILD
ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The purpose of this research is to test the feasibility and efficacy of a brief (one session) preventative intervention using motivational interviewing integrated with social network counseling for substance use among adolescent patients in a primary care setting. One hundred participants will be randomly assigned to either motivational interviewing integrated with social network counseling or attention control conditions. The motivational interviewing integrated with social network counseling condition is expected to show improvement when compared to the attention control condition.


Eligibility criteria: Inclusion Criteria:

* 14-18 years old
* Resident of Richmond VA or greater Richmond area
* Patient at Virginia Commonwealth University or Richmond City Department of Health

Exclusion Criteria:

* Ward of the state
* Not fluent in English
* Incapable of providing consent

Primary outcomes:
measure: Effects of counseling on substance use factors in teens
timeFrame: Feb. 2015
Secondary outcomes:
Other outcomes:
Locations:
city: Richmond
country: United States
facility: Virginia Commonwealth University
state: Virginia
Study officials:
affiliation: Virginia Commonwealth University
name: Michael P Mason, PhD
role: PRINCIPAL_INVESTIGATOR
References: