Clinical trial NCT06413199: Adaptive Response of Brain Towards Resistance Training in Healthy Individuals
Official title: Adaptive Response of Brain Towards Resistance Training in Healthy Individuals
Study type: INTERVENTIONAL
Overall status: RECRUITING
Phase: NA
Conditions: Resistance Training
Keywords: Resistance Training
Performance
Nervous Response
Muscle growth
Exercise Induced Performance
Lead sponsor: Pakistan Society for Rehabilitation of Differently Abled Hospital
Sponsor class: OTHER
Collaborators: name: University of Karachi
First posted: 2024-05-14
Enrollment: 100
Sex: ALL
Minimum age (years): 18
Maximum age (years): 35
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The novelty of this study is to identify the mechanism of nervous system by applying resistance training intervention in healthy individuals.

Detailed description: Resistance training is a form of exercise that is popular particularly for its role in improving athletic performance by increasing muscular strength, power and speed, hypertrophy, local muscular endurance, motor performance, balance and coordination. The objective of the study is to find out the effects of resistance training on Central and Peripheral Nervous System in healthy individuals. A total of 100 participants will be included in the study including both male and female. The study will be divided into two main groups. Experimental group will perform 8-12 Reps with 1.5 sec concentric and 1.5 sec eccentric contraction of bench press with 90 sec of rest between sets with 2 sets per week for 2 months.

1RM of control group will be calculated through the same method and the training protocol for the Control group consisted of 5 attempts to lift as much weight as possible one time for that training visit with 90 seconds of rest between attempts. The load was progressively increased each attempt to try to reach or exceed their previous 1RM.

Eligibility criteria: Inclusion Criteria:

* Body Mass Index should be 18.5-24.9 kg/m2.
* Participants were untrained and had not engaged in resistance exercise within 6 months prior to beginning the study.

Exclusion Criteria:

* Participants with any kind of Gastrointestinal Tract disturbance will be excluded from the study.
* Participants with any kind of Musculoskeletal injury will be excluded from the study.
* Participant with any kind of Neurological disturbance will be excluded from the study.
* Participants who use tobacco products within the previous 6 months.
* Participants who take any type of medication within the previous 6 months.

Primary outcomes:
measure: NCS (Motor Nerve Conduction Study)
timeFrame: • 0 week • 8th week
measure: EEG (Electroencephalography)
timeFrame: • 0 week • 8th week
measure: Dynamometer
timeFrame: • 0 week • 4th week • 8th week
measure: Estimation of Albumin & Globulin ratio
timeFrame: • 0 week • 8th week
Secondary outcomes:
Other outcomes:
Locations:
city: Lahore
country: Pakistan
facility: PSRD Hospital
state: Punjab
Study officials:
affiliation: PSRD College of Rehabilitation Sciences
name: Danish Latif, PhD*
role: PRINCIPAL_INVESTIGATOR
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