louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT06602518: Changes in the Sagittal Pharyngeal Airway Dimension Following Leveling and Alignement in Class II Division 2 Patients
Official title: Changes in the Sagittal Pharyngeal Airway Dimension Following Leveling and Alignement in Class II Division 2 Patients: A Prospective Clinical Trial
Study type: INTERVENTIONAL
Overall status: RECRUITING
Phase: NA
Conditions: Class II Division 2 Malocclusion
Lead sponsor: University of Alexandria
Sponsor class: OTHER
First posted: 2024-09-19
Enrollment: 27
Sex: ALL
Minimum age (years): 12
Maximum age (years): 16
Standard ages: CHILD
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: TREATMENT

Brief summary: Aim of the study: is to compare the changes in the sagittal pharyngeal airway dimension (SPAD) and mandibular position before and after the levelling and alignment stage of orthodontic treatment in Class II division 2 patients.


Eligibility criteria: Inclusion Criteria:

* Class II/2 subjects as per the British Standard Institute Classification.
* Age ranging from 12-16 years, with Cervical Vertebral Maturational Index (CVMI) stages 4, and 5.
* Contact between maxillary and mandibular incisors, with the presence of a deep bite of at least 70%.
* Full permanent dentition, aside from the third molars

Exclusion Criteria:

* Previous orthodontic treatment.
* Patients with severe transverse problems, pain and/or clicking sound in the temporomandibular joint (TMJ).
* Patients with craniofacial anomalies or diagnosed syndromes

Primary outcomes:
measure: Changes in the sagittal pharyngeal airway space (SPAD)
timeFrame: 6 months
Secondary outcomes:
measure: Changes in the mandibular position
timeFrame: 6 months
measure: Sagittal skeletal measurements
timeFrame: 6 months
measure: Vertical skeletal measurements
timeFrame: 6 months
Other outcomes:
Locations:
city: Alexandria
country: Egypt
facility: Faculty of Dentistry, Alexandria University
Study officials:
affiliation: Faculty of Dentistry, Alexandria University, Egypt
name: Farah Y Eid, PhD
role: PRINCIPAL_INVESTIGATOR
affiliation: Faculty of Dentistry, Alexandria University, Egypt
name: Dina Elfouly, PhD
role: STUDY_DIRECTOR
affiliation: Faculty of Dentistry, Alexandria University, Egypt
name: Ahmed Madian, PhD
role: STUDY_CHAIR
References:
Clinical trial NCT02035618: Exercises Associated or Not With Manual Therapy Shoulder Impingement
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Shoulder Impingement
Lead sponsor: Universidade Federal de Sao Carlos
Sponsor class: OTHER
First posted: 2014-01-14
Enrollment: 46
Sex: ALL
Minimum age (years): 18
Maximum age (years): 60
Standard ages: ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: Manual therapy combined with a protocol of therapeutic exercises will increase the beneficial effects on scapular kinematics, myofascial pain and function in subjects with shoulder impingement when compared to exercises only.


Eligibility criteria: Inclusion Criteria:

* history of non-traumatic onset of shoulder pain;
* painful arc during active elevation of the arm;
* one or more positive shoulder impingement tests (Neer, Hawkins and Jobe), or pain during passive or resisted external rotation of the arm at 90° of abduction;
* pain with palpation of the rotator cuff tendons;
* all subjects need also to be able to reach 150° of arm elevation as evaluated by visual observation.

Exclusion Criteria:

* limitation of glenohumeral internal and external rotation as indicative of adhesive capsulitis;
* body mass index \> 28kg/m2 as the amount of subcutaneous tissue can compromise the quality of the signal increasing soft tissue artifact;
* numbness or tingling of the upper limb reproduced by cervical compression test;
* history of clavicle, scapula or humerus fracture;
* history of rotator cuff surgery;
* systemic illnesses;
* positive sulcus or apprehension tests as indicative of instability;
* positive drop arm test as indicative of full thickness tear;
* corticosteroid injection within 3 months prior to intervention, or physiotherapy within 6 months prior to intervention;
* depressive symptoms as evaluated by the Beck Depression Inventory score ( \> 9 points) due to its influence on myofascial pain;
* allergy to tape.

Primary outcomes:
measure: Scapular kinematics
timeFrame: up to 3 months from the initial interview
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
References:
citation: Camargo PR, Alburquerque-Sendin F, Avila MA, Haik MN, Vieira A, Salvini TF. Effects of Stretching and Strengthening Exercises, With and Without Manual Therapy, on Scapular Kinematics, Function, and Pain in Individuals With Shoulder Impingement: A Randomized Controlled Trial. J Orthop Sports Phys Ther. 2015 Dec;45(12):984-97. doi: 10.2519/jospt.2015.5939. Epub 2015 Oct 15.
Clinical trial NCT01882218: Direct Peritoneal Resuscitation Plus Conventional Resuscitation
Official title: A Comparison of Direct Peritoneal Resuscitation Plus Conventional Resuscitation Versus Conventional Resuscitation Alone in Patients Undergoing Hepatic Resection for Cancer
Study type: INTERVENTIONAL
Overall status: WITHDRAWN
Phase: PHASE4
Conditions: Hepatic Cancer
Keywords: Liver cancer
Lead sponsor: University of Louisville
Sponsor class: OTHER
First posted: 2013-06-20
Enrollment: 0
Sex: ALL
Minimum age (years): 18
Maximum age (years): 75
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The purpose of this study is to find out if direct peritoneal resuscitation (DPR) (putting a sugar solution into the abdominal cavity) helps blood flow through vital organs in the body that may suffer from low blood flow due to surgery. We will also try to find out if the DPR will help patients recover faster from liver surgery. Lastly, this study will also try to find if direct peritoneal resuscitation decreases levels of signaling chemicals in the blood called 'cytokines' and a protein called high-mobility group protein 1, which is known to cause tissue damage.

Detailed description: Our study will focus on 108 patients requiring hepatic resection for colorectal cancer metastasis or primary hepatocellular carcinoma. These patients will then be randomized into two 54 patient arms: the control arm of conventional resuscitation only and the experimental arm of conventional resuscitation with DPR immediately post operatively. Patient exclusion criteria will be: 1) unable to obtain proper consent for enrollment, 2) age less than 18 years or greater than 75 years, 3) chronic renal failure, cirrhosis, or congestive heart failure, 4) patients requiring portal venous embolization prior to resection, or 5) women who are pregnant or lactating/breast feeding. A pregnancy test (urine or blood) will be done for female subjects of child bearing potential the day prior or the morning of surgery per the usual standard of care pre-op labs.

Eligibility criteria: Inclusion Criteria:

* Colorectal cancer
* Scheduled for liver resection
* 18 to 75

Exclusion Criteria:

* Chronic renal failure
* Cirrhosis
* Congestive heart failure
* Requiring portal venous embolization prior to resection
* Pregnant or nursing

Primary outcomes:
measure: Morbidity
timeFrame: Six months
Secondary outcomes:
measure: Cytokine levels
timeFrame: Six months
Other outcomes:
Locations:
city: Louisville
country: United States
facility: Norton Hospital
state: Kentucky
city: Louisville
country: United States
facility: University of Louisville Hospital
state: Kentucky
Study officials:
affiliation: U Louisville
name: Jason Smith, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT03165318: Pulsed Electromagnetic Field (PEMF) Systems to Promote the Maintenance of Bone and Muscle
Official title: A Randomized, Sham-Controlled Pilot Study of Pulsed Electromagnetic Field Therapy in Promoting the Maintenance of Muscle Following Anterior Cruciate Ligament (ACL) Reconstruction
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Muscle Loss Post Anterior Cruciate Ligament Reconstruction
Keywords: Pulsed electromagnetic field
Anterior cruciate ligament reconstruction
Muscle
Lead sponsor: National University Hospital, Singapore
Sponsor class: OTHER
Collaborators: name: National University of Singapore
First posted: 2017-05-24
Enrollment: 22
Sex: ALL
Minimum age (years): 18
Maximum age (years): 40
Standard ages: ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: This is a pilot study that evaluates the effect of PEMF in maintaining muscle mass postoperatively in individuals experiencing clinical immobilisation due ACL reconstruction surgery. Half of the participants will receive the PEMF therapy in combination with standard rehabilitation programme, while the other half will receive sham therapy in combination with standard rehabilitation programme.

Detailed description: This is a single-site, randomized, double-blinded, prospective pilot study of the effectiveness of once-weekly PEMF therapy in the promotion of muscle maintenance following ACL reconstruction surgery. Eligible subjects will be randomized in a 1:1 ratio to receive therapy with an active PEMF device or an identical inactive Sham device, in addition to the standard rehabilitation regimen.

Eligibility criteria: Inclusion Criteria:

* Subjects who have undergone unilateral first-time athroscopic reconstruction with single bundle hamstring graft using both transtibial and transportal techniques for rupture anterior cruciate ligament
* Informed consent signed

Exclusion Criteria:

* Subjects requiring concomitant knee ligament reconstruction
* Subjects having other than hamstring graft for the ACL reconstruction
* Subjects with history of cardiac, neurological, and rheumatological diseases, and previous lower limb surgery/ fracture
* Subjects with Leg circumference \> 63 cm
* Pregnant women

Primary outcomes:
measure: Muscle Volume
timeFrame: Week 1 and Week 16 post-ACL reconstruction
Secondary outcomes:
measure: Quadriceps strength
timeFrame: Baseline and Week 8, 12, 16 post-ACL reconstruction
measure: Knee and thigh circumference
timeFrame: Baseline and Week 1, 4, 8, 12, 16 post-ACL reconstruction
measure: Knee Injury and Osteoarthritis Outcome Score (KOOS)
timeFrame: Week 16 post-ACL reconstruction
Other outcomes:
Locations:
city: Singapore
country: Singapore
facility: National University Health System
Study officials:
affiliation: National University Health System
name: Lingaraj Krishna, frcs (Orth)
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT00711113: Study on OsseoSpeed™ Implants Replacing 2-5 Teeth in the Posterior Upper Jaw, Restored With Provisional Teeth Attached 6-7 Weeks Later
Official title: An Open, Prospective Study to Evaluate Implant Stability, Marginal Bone Adaptation and the Survival Rate of Astra Tech Dental Implant System, Fixture Osseospeed™, in Patients With Tooth Loss in the Posterior Maxilla in an Early Loading Protocol.
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Jaw, Edentulous, Partially
Keywords: Jaw, Edentulous, Partially (posterior maxilla)
Lead sponsor: Dentsply Sirona Implants and Consumables
Sponsor class: INDUSTRY
First posted: 2008-07-08
Enrollment: 47
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NON_RANDOMIZED
Intervention model: SINGLE_GROUP
Primary purpose: TREATMENT

Brief summary: The purpose of the study is to evaluate Astra Tech Dental Implant System, Fixture Osseospeed™, in patients with tooth loss in the posterior maxilla in an early loading protocol. Primary objectives are implant stability, marginal bone adaptation and survival rate.


Eligibility criteria: Inclusion Criteria:

* Provision of written informed consent
* 18 years of age and over
* Edentulous in the posterior maxilla, Kennedy classes I or II. Last natural tooth, or previously restored implant in function is canine or first bicuspid.
* Deemed by the investigator as likely to present an initially stabile implant situation suitable for early loading

Exclusion Criteria:

* Untreated caries and/or periodontal disease of residual dentition
* History of edentulism in the area of implant placement of less than two months
* Current need for pre-surgical bone or soft tissue augmentation in the planned implant area.
* History of pre-surgical bone or soft tissue augmentation, within12 months, in the planned implant area.
* Sinus floor thickness of less than 5 mm, verified by periapical radiographs.
* Any systemic or local disease or condition that would compromise post-operative healing and/or osseointegration
* Need for systemic corticosteroids or any other medication that would compromise post-operative healing and/or osseointegration
* Present alcohol or drug abuse
* Unable or unwilling to return for follow-up visits for a period of 5 years
* Current use of smoking tobacco
* Pregnancy or lactation at the time of enrollment

Primary outcomes:
measure: Implant Survival Rate
timeFrame: At 5 year follow-up
measure: Implant Stability
timeFrame: At 1 year follow-up
measure: Marginal Bone Adaptation
timeFrame: At baseline (loading) and at 5 year follow-up
Secondary outcomes:
Other outcomes:
Locations:
city: Iowa City
country: United States
facility: University of Iowa, College of Dentistry, Dow's Institute for Dental Research
state: Iowa
city: San Antonio
country: United States
facility: UTHSCSA
state: Texas
city: Mainz
country: Germany
facility: Universitetsklinik Mainz, Klinik fur ZMK
Study officials:
affiliation: University of Texas
name: James T Mellonig, D.D.S., M.S
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT01601613: Activated Recombinant Human Factor VII in Patients With Dengue Haemorrhagic Fever
Official title: A Multi-centre, Randomised, Double-blind, Parallel Group, Placebo-controlled Comparison of Recombinant Factor VIIa (NovoSeven®) and Standard Haemostatic Replacement Therapy in Patients With Dengue Haemorrhagic Fever
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE2
Conditions: Acquired Bleeding Disorder
Dengue Haemorrhagic Fever
Lead sponsor: Novo Nordisk A/S
Sponsor class: INDUSTRY
First posted: 2012-05-18
Enrollment: 28
Sex: ALL
Maximum age (years): 18
Standard ages: CHILD
ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: This trial is conducted in Asia. The aim of this is to investigate the efficacy and safety of activated recombinant human factor VII (rFVIIa) in achieving haemostasis in patients with Dengue haemorrhagic fever (DHF).


Eligibility criteria: Inclusion Criteria:

* Patients with the clinical diagnosis of Dengue Haemorrhagic Fever (DHF)
* Patients with a clinical diagnosis of DHF Grades II and III8, requiring standard replacement therapy

Exclusion Criteria:

* Patients with a clinical diagnosis of DHF Grade IV
* Known or suspected allergy to trial product or related products
* Known hypersensitivity to mouse, hamster or bovine protein
* Prior treatment with activated recombinant human factor VII

Primary outcomes:
measure: Proportion of subjects with evidence of bleeding as assessed at 2 hours after first trial product administration
Secondary outcomes:
measure: Proportion of subjects requiring standard haemostatic replacement therapy during 2 hours after first trial product administration
measure: Proportion of subjects with effective haemostatic efficacy at 2 hours after first trial product administration
measure: Coagulation related variables
measure: Adverse events
Other outcomes:
Locations:
city: Kuala Lumpur
country: Malaysia
facility: Novo Nordisk Investigational Site
city: Manila
country: Philippines
facility: Novo Nordisk Investigational Site
city: Muntinlupa City
country: Philippines
facility: Novo Nordisk Investigational Site
city: Quezon City
country: Philippines
facility: Novo Nordisk Investigational Site
city: Bangkok
country: Thailand
facility: Novo Nordisk Investigational Site
city: Chiang Mai
country: Thailand
facility: Novo Nordisk Investigational Site
city: Khon Kean
country: Thailand
facility: Novo Nordisk Investigational Site
city: Pisanulok
country: Thailand
facility: Novo Nordisk Investigational Site
city: Ubonratchathani
country: Thailand
facility: Novo Nordisk Investigational Site
Study officials:
affiliation: Novo Nordisk A/S
name: Global Clinical Registry (GCR, 1452)
role: STUDY_DIRECTOR
References:
citation: Chuansumrit A, Wangruangsatid S, Lektrakul Y, Chua MN, Zeta Capeding MR, Bech OM; Dengue Study Group. Control of bleeding in children with Dengue hemorrhagic fever using recombinant activated factor VII: a randomized, double-blind, placebo-controlled study. Blood Coagul Fibrinolysis. 2005 Nov;16(8):549-55. doi: 10.1097/01.mbc.0000186837.78432.2f.
Clinical trial NCT02720913: COR-KNOT Versus Manually Hand-tied Knots
Official title: COR-KNOT Versus Manually Hand-tied Knots
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Suture Tying
Keywords: Time
COR-KNOT
Standard
Cost
Lead sponsor: The Cleveland Clinic
Sponsor class: OTHER
First posted: 2016-03-28
Enrollment: 50
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The COR-KNOT technology (LSI SOLUTIONS, Victor, New York USA) was developed to replace suture tying with a faster procedure during surgery. While preclinical studies confirmed the speed of COR-KNOT use, no clinical studies have quantitatively compared the speed of suture fixation delivered by the COR-KNOT device with the speed of conventional hand-tied knots. COR-KNOT is expensive, costing 189 $ per application. Given this added expense, it is important to quantify the time-saved by application of this technology.

Detailed description: The COR-KNOT device was developed to make suture fixation faster and save operative time. With a single squeeze of the lever, the device remotely and automatically secures sutures with a titanium fastener, while also simultaneously trimming excess suture tails. This device has been accepted by cardiac surgeons for the recognized benefits of time savings, simplicity, and reliability.

While the device presents ergonomic advantages during minimally invasive cardiac surgery, it enjoys widespread use in sternotomy-based, standard heart surgery. The relative cost of the device as a function of time saved has not been assessed. The purpose of this trial is to determine the relative time savings and cost of COR-KNOT compared to standard hand-tied knots in patients undergoing mitral/tricuspid ring annuloplasty repairs via traditional open heart surgery. Valve repair surgery is a common setting for COR-KNOT use and therefore serves as an appropriate procedure for evaluation of the technology.

The investigators propose a prospective, randomized trial in patients undergoing mitral or tricuspid ring annuloplasty repair to 1) Determine the time require per knot for COR-KNOT versus standard hand-tied knots and 2) Quantify the relative cost of COR-KNOT versus that of standard, hand-tied knots. Data from this study will enable the investigators to determine the cost-benefit of using COR-KNOT technology in cardiac surgery.

Eligibility criteria: Inclusion Criteria:

* Scheduled for Valvular ring annuloplasty for mitral and/or tricuspid valve repair
* Age \> 18 years
* Able and willing to give informed consent

Exclusion Criteria:

* None

Primary outcomes:
measure: Time (seconds) required to use COR-KNOT vs. Standard Suture Tying
timeFrame: 60 seconds
Secondary outcomes:
measure: Cost (US Dollar) of using COR-KNOT vs. Standard Suture Tying
timeFrame: 60 seconds
Other outcomes:
Locations:
Study officials:
affiliation: The Cleveland Clinic
name: Marc A Gillinov, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT00338013: Patient Sleep Position Questionnaire
Official title: Patient Sleep Position Questionnaire
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Sleep
Keywords: sleep
Lead sponsor: Vanderbilt University
Sponsor class: OTHER
First posted: 2006-06-20
Enrollment: 140
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: Primary Care Clinic

Brief summary: You are being asked to participate in this study because we would like to know if sleeping may affect eye pressure.

Detailed description: Completion of the questionnaire is done solely for research purposes and is not part of your routine care.

Approximate duration- Up to 10 minutes to complete the questionnaire.

Eligibility criteria: Inclusion Criteria:

* Glaucoma
* Age-matched controls
* Adults

Exclusion Criteria:

* Medical students
* Children

Primary outcomes:
Secondary outcomes:
Other outcomes:
Locations:
city: Nashville
country: United States
facility: Vanderbilt University
state: Tennessee
Study officials:
affiliation: Vanderbilt University
name: Karen Joos, MD, PhD
role: PRINCIPAL_INVESTIGATOR
References: