Clinical trial NCT03722953: Cerebrovascular Response to Acute Exercise
Official title: The Role of Shear Stress in the Cerebrovascular Response to Acute Exercise
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Healthy
Physical Activity
Keywords: Exercise
Treadmill
Vascular Function
Intensity
Lead sponsor: University of Wisconsin, Madison
Sponsor class: OTHER
First posted: 2018-10-29
Enrollment: 18
Sex: ALL
Minimum age (years): 20
Maximum age (years): 40
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: BASIC_SCIENCE

Brief summary: Cerebrovascular function and peripheral vascular function will be measured in healthy young adults, before and after acute bouts of aerobic exercise at various intensities.

Detailed description: Acute bouts of aerobic exercise have been shown to enhance vascular reactivity of the peripheral circulation; however, the effects of a single exercise session on the cerebral circulation are unknown. This study will measure cerebrovascular function and peripheral vascular function before and after aerobic exercise at high and low intensities.

The research aims are:

1. To determine if a single bout of aerobic exercise acutely enhances cerebrovascular function
2. To determine the effect of aerobic exercise intensity and dose on cerebrovascular function in healthy adults.
3. To determine if the acute exercise-induced changes in cerebrovascular function are associated with acute exercise-induced changes in peripheral vascular function in healthy adults.

Eligibility criteria: Inclusion Criteria:

* Between 20-40 years old
* BMI \< 30 kg/m2
* Recreationally active
* Experience running on a treadmill

Exclusion Criteria:

* Current smoker
* History or evidence of: hepatic disease, renal disease, hematological disease, cardiovascular disease, stroke/neurovascular disease, diabetes
* Taking blood pressure medication
* History of depression or other mood related disorders
* Part of a vulnerable population (e.g. pregnant women, prisoner, individuals lacking capacity to consent, etc.)

Primary outcomes:
measure: Cerebrovascular function
timeFrame: Change in cerebrovascular function: measurements occur at baseline and 90 minutes post aerobic exercise to quantify magnitude of change.
measure: Peripheral vascular function
timeFrame: Change in peripheral vascular function: measurements occur at baseline and 60 minutes post aerobic exercise to quantify magnitude of change.
Secondary outcomes:
Other outcomes:
Locations:
city: Madison
country: United States
facility: Gymnasium-Natatorium
state: Wisconsin
Study officials:
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