Clinical trial NCT05705713: First-day Computed Tomography: Does it Has a Role in the Assessment of Patients With Inhalation Lung Injury?
Official title: First-day Computed Tomography: Does it Has a Role in the Assessment of Patients With Inhalation Lung Injury?
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Inhalation Injury
Keywords: inhalation injury
Bronchial wall thickening
Radiologist score
computed tomography.
Lead sponsor: Menoufia University
Sponsor class: OTHER
First posted: 2023-01-31
Enrollment: 58
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: DIAGNOSTIC

Brief summary: A major risk factor for death in burn victims is inhalation lung injury. Diagnostic criteria and severity grading are not well understood. After an inhalation injury, the mucociliary escalator is impaired by induced mucosal hyperemia, which includes Edema, increased mucous production, and airway exudation, and these insults worsen airway narrowing which interferes with ventilation. Multimodal therapy and quick bronchoscopic diagnosis improve patient outcomes. Early identification and classification of inhalation injuries improve patient outcomes. Chest CT may be employed as an alternative to or supplement to the bronchoscopy as well as a diagnostic and prognostic tool. In this study, the diagnostic and prognostic value of bronchial wall thickening as a radiological CT finding in inhalation lung damage and the radiologist score (RADS) were evaluated.

Detailed description: Forty-eight patients with inhalation lung injury were included in the study as the case group, and ten patients without ILI were chosen as the control group. Both groups were recruited from the burn and plastic department. A fiberoptic bronchoscope was performed during the first 12 hours of a suspected ILI to confirm the diagnosis. After performing an initial chest X-ray, computed tomography was used to calculate the radiologist score (RADS) and the thickness of the bronchial walls (BWT).

Eligibility criteria: Inclusion Criteria:

* any patient with a suspected inhalational lung injury

Exclusion Criteria:

* less than 18 years old,
* patients who had their CT scan after 24 hours after their admission
* patients who couldn't finish all of the study steps.
* patients that are known to have any parenchymal lung disorders.

Primary outcomes:
measure: bronchial wall thickening (BWT)
timeFrame: 24 hours
measure: Radiologist score
timeFrame: 24 hours
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
References:
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