Clinical trial NCT04663919: Comparison of the Effects of Weight Changes on Serum Adipokines in Patients Diagnosed With Anorexia Nervosa and Morbid Obesity
Official title: Comparison of the Effects of Weight Changes on Serum Adipokines in Patients Diagnosed With Anorexia Nervosa and Morbid Obesity
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Anorexia Nervosa
Bariatric Surgery
Weight Change, Body
Keywords: adipocytokines
leptin
adiponectin
omentin
apelin
IL-6
Anorexia Nervosa
Bariatric Surgery
fat mass
Lead sponsor: Istanbul University
Sponsor class: OTHER
First posted: 2020-12-11
Enrollment: 55
Sex: ALL
Minimum age (years): 13
Maximum age (years): 60
Standard ages: CHILD
ADULT
Accepts healthy volunteers: yes
Allocation: NON_RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: In this study, when patients diagnosed with AN started treatment and their weight increased by 10%; On the other hand, it was aimed to compare the changes in serum adipokine levels observed in morbidly obese patients before bariatric surgery and when they lost 10% of their post-op weight with both anthropometric measurements, biochemical parameters, and values of healthy volunteers.

Detailed description: The most characteristic feature of obesity is the increase in adipose tissue. On the contrary, in anorexia nervosa, there is a decrease in adipose tissue enough to impair neuroendocrine functions. Adipose tissue is formed by loosely binding lipid-filled cells called adipocytes and is now considered an important part of energy metabolism. Adipokines it secretes play a role in many physiological processes of the body such as nutrition, appetite, energy balance, insulin, and glucose metabolism, lipid metabolism, regulation of blood pressure, vascular remodeling, coagulation, and inflammation.

Therefore, changes in the amount of body fat in these two patient groups, which are at the two ends of the spectrum, affect both the biochemical parameters and physiological functions of the patients in different ways. It is expected that both adipokine levels and biochemical parameters will approach the values of healthy subjects with a decrease in adipose tissue of clinically morbidly obese patients and an increase in adipose tissue of patients with AN. However, in some studies comparing the parameters of patients with constitutionally weak patients and patients with AN, results contrary to expectations were obtained. In this study, we compared the extent to which weight changes changed adipokines and correlated with biochemical parameters based on healthy and normal-weight volunteers.

Eligibility criteria: Inclusion Criteria:

* for Anorexia Nervosa group:

  * Have been diagnosed with anorexia nervosa
  * BMI \<18 kg/m2
  * Good general health
  * Volunteering to participate in the study
* for Morbidly Obese group:

  * Who was diagnosed with morbid obesity and planned to undergo RYGB operation
  * BMI\> 40 kg/m2
  * Volunteering to participate in the study
* for Healthy Volunteers:

  * Good general health
  * BMI \>20 and \<30 kg/m2
  * Volunteering to participate in the study

Exclusion Criteria:

* \<13 and\> 60 years old
* to had type 2 diabetes, hypertension, liver and kidney failure, cancer, or a chronic disease

Primary outcomes:
measure: Plasma Leptin levels changes:
timeFrame: 3 months on average
measure: Plasma Apelin levels changes
timeFrame: 3 months on average
measure: Plasma Omentin levels changes
timeFrame: 3 months on average
measure: Plasma Adiponectin levels changes
timeFrame: 3 months on average
measure: Plasma IL-6 levels changes
timeFrame: 3 months on average
Secondary outcomes:
measure: Weight change
timeFrame: 3 months on average
measure: Fat mass change
timeFrame: 3 months on average
measure: Fat free mass changes
timeFrame: 3 months on average
Other outcomes:
measure: Serum glucose change
timeFrame: 3 months on average
measure: Serum insulin change
timeFrame: 3 months on average
measure: Serum CRP change
timeFrame: 3 months on average
Locations:
Study officials:
References: