louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT00806013: Study the Effects of CYP2C Polymorphisms on the Pharmacokinetics and Pharmacodynamics of Glipizide
Official title: Study the Effects of CYP2C9 and CYP2C19 Polymorphisms on the Pharmacokinetics and Pharmacodynamics of Glipizide in Healthy Chinese Subject
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Healthy
Keywords: genotype
Lead sponsor: Chinese Academy of Sciences
Sponsor class: OTHER_GOV
First posted: 2008-12-10
Enrollment: 36
Sex: MALE
Minimum age (years): 21
Maximum age (years): 27
Standard ages: ADULT
Accepts healthy volunteers: yes
Observational model: CASE_CONTROL
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: Male Chinese subjects with different geontype of CYP2C9 and CYP2C19 were enrolled in this study. They are divided into three groups by different geontype.

Brief summary: The aims of this study were to investigate the effects of CYP2C9 and CYP2C19 polymorphisms on the pharmacokinetics and pharmacodynamics of glipizide in healthy Chinese subjects.

Detailed description: Compared with CYP2C19, CYP2C9 polymorphism appears to have a dominant role in glipizide pharmacokinetics and pharmacodynamics in vivo. This indicated that dose adjustment based on CYP2C9 genotype may improve antidiabetic treatment.

Eligibility criteria: Inclusion Criteria:

* nonsmokers and in good health

Exclusion Criteria:

* family history of diabetes mellitus
* taking any drug, alcohol, foods containing caffeine, or grapefruits and juice before study

Primary outcomes:
Secondary outcomes:
Other outcomes:
Locations:
city: Shenyang
country: China
facility: The second hospital to Liaoning University of TCM
state: Liaoning
Study officials:
affiliation: Shanghai Institute of Materia Medica, Chinese Academy of Sciences
name: Bo Tan
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT06581913: Investigation of Eating Awareness,Eating Cravings, Wellness Awareness and Health Perception
Official title: Investigation of Eating Awareness, Acceptance of Eating Cravings, Wellness Awareness and Health Perception in Healthy Young Adults
Study type: OBSERVATIONAL
Overall status: ACTIVE_NOT_RECRUITING
Conditions: Healthy Young Adults
Keywords: students
awareness
eating
perception
Lead sponsor: Nigde Omer Halisdemir University
Sponsor class: OTHER
Collaborators: name: The Scientific and Technological Research Council of Turkey
First posted: 2024-09-03
Enrollment: 356
Sex: ALL
Minimum age (years): 18
Maximum age (years): 30
Standard ages: ADULT
Accepts healthy volunteers: yes
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Healthy young individuals

Brief summary: In this project, eating awareness, acceptance of food cravings, healthy life awareness and health perception will be examined in healthy young adults.

Detailed description: In this project, eating awareness, acceptance of eating desire, healthy life awareness and health perception will be examined in healthy young adults. Accordingly, 356 healthy young individuals between the ages of 18-30 will be included in the study. The questionnaires and scales used as data collection tools in this research, which is planned as a survey study, will be filled in by face-to-face interview method after the written and verbal voluntary consent of the individuals is obtained. The evaluation consists of five sections. It is aimed to raise awareness about the conditions that are found to be related.

Eligibility criteria: Inclusion Criteria:

* 18-30 years old

Exclusion Criteria:

* Under 18 years old
* not volunteering

Primary outcomes:
measure: Eating Awareness,
timeFrame: Baseline
measure: Acceptance of Food Cravings,
timeFrame: Baseline
measure: Healthy Life Awareness
timeFrame: Baseline
measure: Health Perception
timeFrame: Baseline
measure: descriptive assessment
timeFrame: Baseline
Secondary outcomes:
Other outcomes:
Locations:
city: Nigde
country: Turkey
facility: Nigde Omer Halisdemir University
state: Bor
Study officials:
affiliation: Nigde Omer Halisdemir University
name: Elif Gökçe İnbaşı, MSc.
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT02275013: Levosimendan Administration and Outcome in Cardiac Surgery
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Treatment of Left Heart Insufficiency in an Operative Setting of Cardiac Surgery
Lead sponsor: Charite University, Berlin, Germany
Sponsor class: OTHER
First posted: 2014-10-27
Enrollment: 159
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: RETROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Cardiac surgery patients

Brief summary: To assess the effects on outcome of levosimendan with respect to timing of its administration on the postoperative course of high-risk cardiac surgery patients in a retrospective observational study.


Eligibility criteria: Inclusion Criteria:

* patients undergoing cardiac surgery between 2006 and 2013
* levosimendan administration within 24 hours of postoperative ICU admission

Exclusion Criteria:

* patients younger than 18

Primary outcomes:
measure: In-hospital mortality
timeFrame: until discharge, an average of 3 weeks length of stay
measure: 1 year follow-up mortality
timeFrame: 1 year after surgery
Secondary outcomes:
measure: Duration of mechanical ventilation
timeFrame: until discharge, an average of 3 weeks length of stay
measure: Incidence of renal dysfunction
timeFrame: until discharge, an average of 3 weeks length of stay
measure: Incidence of renal replacement therapy
timeFrame: until discharge, an average of 3 weeks length of stay
Other outcomes:
Locations:
city: Berlin
country: Germany
facility: Charité University Medicine
Study officials:
References:
citation: Treskatsch S, Balzer F, Geyer T, Spies CD, Kastrup M, Grubitzsch H, Wernecke KD, Erb JM, Braun JP, Sander M. Early levosimendan administration is associated with decreased mortality after cardiac surgery. J Crit Care. 2015 Aug;30(4):859.e1-6. doi: 10.1016/j.jcrc.2015.03.008. Epub 2015 Mar 13.
Clinical trial NCT05538013: Obesity Awareness, Physical Activity Level and Sedentary Behavior in Obese Women
Official title: Investigation of the Relationship of Obesity Awareness With Physical Activity Level and Sedentary Behavior in Obese Women
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Obesity
Keywords: obesity
women
physical activity
sedantary
Lead sponsor: Biruni University
Sponsor class: OTHER
First posted: 2022-09-13
Enrollment: 82
Sex: FEMALE
Minimum age (years): 18
Maximum age (years): 65
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: COHORT
Time perspective: CROSS_SECTIONAL
Sampling method: PROBABILITY_SAMPLE
Study population: The study will consist of 70 obese women volunteers aged between 18-65 years.

Brief summary: It is known that the incidence of obesity, which is a global health problem, is higher in women. The aim of this study is to examine the relationship of obesity awareness with physical activity level and sedentary behavior in obese women.

Detailed description: Obese people are at risk for medical conditions that can lead to greater morbidity and mortality. It is known that the incidence of obesity, which is a global health problem, is higher in women. Lack of physical activity and sedentary behavior are well-known risk factors for obesity and the relationship between them has been supported by many studies. As a matter of fact, some studies have reported that public health programs should focus on increasing individuals' physical activity levels as well as reducing sitting time. While examining the sedentary behavior and physical activity levels of obese women, evaluating their obesity awareness status, can facilitate increasing their awareness of the disease, initiating and complying with treatment. The aim of this study is to examine the relationship of obesity awareness with physical activity level and sedentary behavior in obese women.

Eligibility criteria: Inclusion Criteria:

* The women who are ages between 18-65 years,
* BMI ≥ 30.0 kg/m2 according to WHO classification.

Exclusion Criteria:

* BMI \< 30.0 kg/m2 according to WHO classification,
* Male participants,
* Inability to cooperate with assessments,
* Those who have had severe trauma or surgery that limit physical activities in the last 6 months,
* Those who have orthopedic, neurological, cardiovascular problems that limit / prevent ambulation,
* Pregnancy or suspected pregnancy,
* Individuals are included in a rehabilitation program.

Primary outcomes:
measure: Obesity Awareness
timeFrame: baseline
Secondary outcomes:
measure: Sedentary Behavior Questionnaire
timeFrame: baseline
measure: International Physical Activity Questionnaire Short Form
timeFrame: baseline
measure: Waist circumference
timeFrame: baseline
measure: Body fat-muscle ratios
timeFrame: baseline
Other outcomes:
Locations:
city: Istanbul
country: Turkey
facility: Bezmi Alem Vakıf University
Study officials:
affiliation: Biruni University
name: Buket AKINCI, PT, PhD
role: STUDY_CHAIR
References:
Clinical trial NCT03616613: Aortic Abdominal Aneurysm Pilot Screening Programme
Official title: Analysis of Aortic Abdominal Aneurysm Prevalence in a Population Pilot Screening Program Based on Primary Care Duplex Ultrasound Evaluation
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Aortic Aneurysm, Abdominal
Lead sponsor: Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
Sponsor class: OTHER
First posted: 2018-08-06
Enrollment: 2194
Sex: ALL
Minimum age (years): 65
Maximum age (years): 65
Standard ages: OLDER_ADULT
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: All men and a random sample of women born in 1952 in Barcelona in the area that depends from Hospital de la Santa Creu i Sant Pau.

Brief summary: Populational abdominal aortic aneurysm (AAA) pilot screening programme performed by duplex ultrasonography in population born in 1952 in health areas depending from Hospital de la Santa Creu i Sant Pau in Barcelona. Descriptive data analysis and cost-effectiveness study will be performed.

Detailed description: Populational abdominal aortic aneurysm (AAA) pilot screening programme performed by duplex ultrasonography in population born in 1952 in areas depending from Hospital de la Santa Creu i Sant Pau in Barcelona. Ultrasonography evaluations will be performed in primary health centers by previously trained doctors according to study protocol and AAA management will be according to United Kingdom's National Health Service screening model. A descriptive analysis will be performed to estimate local population prevalence of AAA in both men and women in order to create the basis for a future state AAA screening programme. A cost-effectiveness analysis will be performed in order to assess optimal screening strategies in our population.

Eligibility criteria: Inclusion Criteria:

* All men in our area's population census and an aleatory sample of women born in 1952 living in Hospital de la Santa Creu i Sant Pau area.

Exclusion Criteria:

* Previously detected or operated AAA
* Fragile patients not eligible for AAA repair if needed
* Dead people when contacted
* Eligible people refusing to participate
* Eligible people failed to be contacted twice by our department

Primary outcomes:
measure: Abdominal aortic measurement
timeFrame: Days (only one day measurement is performed)
Secondary outcomes:
measure: Smoking habits
timeFrame: 1 day
measure: Surgical intervention if needed
timeFrame: 1 day
measure: Family AAA history
timeFrame: 1 day
measure: Personal Cardiovascular Risk Factors
timeFrame: 1 day
measure: Dislipidaemia
timeFrame: 1 day
measure: Arterial Hypertension
timeFrame: 1 day
measure: Height
timeFrame: 1 day
measure: Weight
timeFrame: 1 day
measure: Abdominal perimeter
timeFrame: 1 day
measure: Goldberg questionnaire
timeFrame: 1 day
measure: EuroQOL 5 score
timeFrame: 1 day
Other outcomes:
Locations:
Study officials:
References:
Clinical trial NCT01093313: Attention Training and Cognitive Therapy
Official title: Comparison of Attention Training and Cognitive Therapy in the Treatment of Social Phobia: a Randomized Controlled Trial
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Social Phobia
Lead sponsor: University of Sydney
Sponsor class: OTHER
First posted: 2010-03-25
Enrollment: 46
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The present study aimed to investigate the efficacy and process of change that occurs in Attention Training in comparison to an established treatment for social phobia, Cognitive Therapy. A randomized trial was conducted in which participants were allocated to either six weeks of Attention Training or Cognitive Therapy. It was hypothesized that both treatments would be effective in reducing social phobia symptoms, but that Attention Training would work primarily by reducing levels of self focused attention, while Cognitive Therapy would work through changes to probability and threat appraisals.


Eligibility criteria: Inclusion Criteria:

* 18 years of age,
* be fluent in English
* have a primary concern of social anxiety that met DSM-IV criteria (APA, 2000) for social phobia. Both subtypes of social phobia, specific and generalized, were accepted into the study.

Exclusion Criteria:

* the presence of comorbid condition(s) that were more severe than the presenting social phobia

Primary outcomes:
Secondary outcomes:
Other outcomes:
Locations:
city: Sydney
country: Australia
facility: The University of Sydney
state: New South Wales
Study officials:
affiliation: University of Sydney
name: Maree Abbott, PhD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT03103113: The Evolution of Relationship Between Results of Peripheral Blood Test and Outcomes of in Vitro Fertilization
Official title: Division of Infertility, Lee Women's Hospital, Taichung, Taiwan
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Infertility, Female
Immune Tolerance
Lead sponsor: Chung Shan Medical University
Sponsor class: OTHER
First posted: 2017-04-06
Enrollment: 500
Sex: FEMALE
Minimum age (years): 20
Maximum age (years): 50
Standard ages: ADULT
Accepts healthy volunteers: yes
Observational model: COHORT
Time perspective: RETROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: Patients had underwent infertility blood test and in vitro fertilization treatment in Lee's women hospital

Brief summary: The purpose of this study was to assess the relationship between infertility blood test results and outcomes of pregnancy and alive birth of women who underwent with or without intravenous immunoglobulin (IVIG) before in vitro fertilization.

Detailed description: Study Design (Brief Description)

1. Inclusion criteria Patients had underwent infertility blood test or treatment in Lee's women hospital
2. Exclusion criteria No
3. Endpoint

1. Values of blood test (PTT, IDM, ANA, Lupus, protein-s) 2. Embryo quality 3. Results of intravenous immunoglobulin (IVIG) treatment (pregnancy or not) 4. Alive birth rate

4. Withdraw criteria and rescue medication No 5. Sample Size and Study Duration Sample Size: total 500 women who underwent IVF treatments and tests from Jan. 2007 to Dec. 2010.

Study Duration: from date of IRB agreement to Dec. 2012 6. Please specify objectives of study when collecting extra specimen from participants No more need to collect extra specimen from participants in this study 7. Expected Endpoints of Treatment No 8. Others No

Eligibility criteria: Inclusion Criteria:

* Patients had underwent both infertility blood test and IVF treatment in Lee's women hospital

Exclusion Criteria:

* No

Primary outcomes:
measure: implantation rate
timeFrame: 6-8 weaks after last menstrual
Secondary outcomes:
measure: live birth rate
timeFrame: live birth after pregnant
Other outcomes:
Locations:
Study officials:
affiliation: Lee's Women Hospital, Taichung, Taiwan
name: Maw Sheng Lee
role: STUDY_CHAIR
References:
Clinical trial NCT02211313: Evaluation of Ureteral Stents in the Management of Stone Disease
Official title: Evaluation of Ureteral Stents in the Management of Stone Disease
Study type: INTERVENTIONAL
Overall status: TERMINATED
Phase: NA
Conditions: Urinary Stones
Urinary Tract Stones
Lead sponsor: Washington University School of Medicine
Sponsor class: OTHER
First posted: 2014-08-07
Enrollment: 41
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: OTHER

Brief summary: A thin tube, called a ureteral stent, is inserted into the ureter and is commonly used as treatment of urinary stone disease. Stents are designed to help provide drainage of the kidney in the setting of an obstructing stone, or postoperative swelling of the ureter. Though their presence is only temporary, stents are associated with a significant amount of patient discomfort and bother, which can negatively impact overall satisfaction. Over the past decades, there have been refinements in stent technology and usage philosophy. Smaller and softer stents are now available for use in patients, though studies evaluating the relative benefits have been conflicting. The investigators aim to evaluate the effect of stent size and composition upon outcomes after the treatment of stone disease, including patient comfort and satisfaction.


Eligibility criteria: Inclusion Criteria:

1. Over 18 years of age and willing and able to provide informed consent
2. Patients with current urinary stone disease, undergoing any of the following procedures:

   * cystoscopy with stent placement
   * ureteroscopy with intracorporeal lithotripsy

Exclusion Criteria:

1. Patients with compromised urinary tract due to cancer (e.g. bladder tumor, ureteral obstruction from non-GU malignancy)
2. Patients requiring bilateral surgical stone management procedure
3. Patients with any single stone exceeding 1.5 cm
4. Patients with severe concurrent disease, infection, or co-morbidity that, in the judgment of the investigator, would render the patient inappropriate for enrollment
5. Any patient who is on anticholinergic medication at baseline

Primary outcomes:
measure: Change From Baseline in Pain on the 10-point Analog Pain Scale at Day 7 Post Stent Removal.
timeFrame: Baseline, day 7 post stent removal
Secondary outcomes:
Other outcomes:
Locations:
city: Saint Louis
country: United States
facility: Washington University School of Medicine
state: Missouri
Study officials:
affiliation: Washington UniversitySchool of Medicine
name: Alana C Desai, M.D.
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT03461913: Can Shorter Time Intervals Help the Baby Survive the Triad Effect of Maternal Hypertension, Caesarean Section and Spinal Anesthesia?
Official title: Can Shorter Time Intervals Help the Baby Survive the Triad Effect of Maternal Hypertension, Caesarean Section and Spinal Anesthesia?
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Neonatal Hypoxia and Asphyxia
Lead sponsor: Cairo University
Sponsor class: OTHER
First posted: 2018-03-12
Enrollment: 200
Sex: FEMALE
Minimum age (years): 18
Maximum age (years): 40
Standard ages: ADULT
Accepts healthy volunteers: no
Allocation: NON_RANDOMIZED
Intervention model: PARALLEL
Primary purpose: PREVENTION

Brief summary: Patients were classified into two equal groups using the presence or absence of hypertension during pregnancy into: hypertensive group (BP\>140/90) and normotensive group (BP≤140/90. The surgical time intervals are assessed and classified the patients accordingly into short and log time interval subgroups (induction of regional anesthesia to delivery (I-D), initial skin incision to delivery (S-D), and uterine incision to delivery (U-D)

Detailed description: Surgical times components; induction of regional anesthesia till delivery (I-D interval); incision of the skin till delivery (S-D interval); and incision of the uterus till delivery (U-D interval)) were recorded using a stopwatch.

Immediately after delivery, umbilical cords were clamped on both ends and an arterial blood sample was collected anaerobically in a pre-heparinized insulin syringe. PH, base excess (BE), carbon dioxide pressure (PCO2), Oxygen pressure (PO2) and Bicarbonate (HCO3) levels were measured at 37oC by pH and gas analyzer (Gem, Premier3000, USA). The gas analysis was done in less than 30 minutes after sampling.

Apgar score was assessed by a neonatologist at the 1st and 5th minutes after birth . Advanced resuscitation included positive pressure ventilation, chest compression and/or drugs administration. All resuscitated babies were transferred to neonatal intensive care unit for post resuscitation care. Fetal distress was defined by an umbilical cord pH \<7.12

Eligibility criteria: Inclusion Criteria:

* full term pregnancy
* singleton pregnancy
* no medical disorders except hypertension in group 2

Exclusion Criteria:

* Multiple pregnancies
* complicated pre-eclamptic cases as placental abruption, eclampsia or HELLP syndrome,
* preterm pregnancies,
* true knots of the cord
* reduced liquor,
* in labour patients,
* fetal distress
* infants with major congenital malformations

Primary outcomes:
measure: umbilical cord Ph
timeFrame: immediately after delivery
Secondary outcomes:
measure: Apgar score
timeFrame: 1 and 5 minutes after delivery
Other outcomes:
Locations:
city: Cairo
country: Egypt
facility: Kasr Alainy medical school
Study officials:
affiliation: professor
name: Ahmed Maged, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT02857413: Frequency of Xerostomia and Their Management in Upper Aerodigestive Tract Cancer Patients After the End of Radiotherapy
Official title: Assessment of Frequency of Xerostomia and Their Care Management in Upper Aerodigestive Tract Cancer Patients After the End of Radiotherapy
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Head and Neck Neoplasms
Keywords: Xerostomia
Radiotherapy
Lead sponsor: Centre Hospitalier Universitaire de Besancon
Sponsor class: OTHER
First posted: 2016-08-05
Enrollment: 42
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: patient with head and neck cancer after radiotherapy treatment

Brief summary: The aim of this study is the evaluation of the frequency of xerostomia and their management after radiotherapy in head and neck cancer.

The quality of life of these patients is also analysed with European Organization for Research and Treatment of Cancer Quality of life Questionnaire H\&N35 (EORTC QLQ H\&N35).


Eligibility criteria: Inclusion Criteria:

* patient with head and neck cancer after radiotherapy treatment

Exclusion Criteria:

* patient already treated for xerostomia for other reason : Sjögren's syndrome, medication, diabetes,...

Primary outcomes:
measure: Frequency of xerostomia and their management after radiotherapy in head and neck cancer
timeFrame: at enrollment
Secondary outcomes:
measure: quality of life af patients after radiotherapy in head and neck cancer
timeFrame: at enrollment
Other outcomes:
Locations:
city: Besançon
country: France
facility: CHU Besançon
Study officials:
affiliation: CHU Besançon
name: Edouard Euvrard, MD
role: PRINCIPAL_INVESTIGATOR
References: