Clinical trial NCT01457534: The Predictors for Continuous Renal Replacement Therapy in Liver Transplant Patient
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Liver Transplantation
Lead sponsor: Yonsei University
Sponsor class: OTHER
First posted: 2011-10-24
Enrollment: 148
Sex: ALL
Minimum age (years): 19
Maximum age (years): 65
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: CASE_CONTROL
Time perspective: RETROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: the data of 148 liver transplant patients from January 2008 to December 2011 at Severance Hospital, Yonsei University HealthSystem, in Seoul, Korea. The number of patients treated with CRRT was 44 (18 patients from living and 26 from deceased donors) and those without CRRT was 104.

Brief summary: Background. Acute renal failure after liver transplantation (LT) requiring continuous renal replacement therapy (CRRT) adversely affects patient survival. However, there are few reports to assess the predictors for postoperative CRRT in liver transplant patients. The investigators undertook this study to identify perioperative factors that would predict patients at risk of CRRT.

Patients and Methods. The investigators retrospectively reviewed the data of 148 liver transplant patients from January 2007 to November 2010 at Severance Hospital, Yonsei University HealthSystem, in Seoul, Korea. The number of patients treated with CRRT was 44 (18 patients from living and 26 from deceased donors) and those without CRRT was 104. Univariate and stepwise logistic multivariate analyses were performed.


Eligibility criteria: Inclusion Criteria:

* Age 19-65 year
* Liver transplant patients from January 2008 to December 2011

Exclusion Criteria:

* Patients treated with CRRT before transplantation

Primary outcomes:
measure: status before operation
timeFrame: 1 day before operation
measure: the amount of ascites
timeFrame: intraoperative
measure: the duration of anesthesia and operation
timeFrame: intraoperative
measure: intraoperative hemodynamic instability
timeFrame: intraoperative
measure: intraoperative bleeding
timeFrame: intraoperative
measure: Intraoperative urine output
timeFrame: intraoperative
measure: the types of donation(living or deceased donor)
timeFrame: intraoperative
measure: survival rate
timeFrame: on the postoperative 28th days, 365 days
measure: postoperative bleeding amount
timeFrame: on the postoperative 28th days, 365 days.
measure: postoperative CRRT(continuous renal replacement therapy),
timeFrame: on the postoperative 28th days, 365days
measure: mortality
timeFrame: on the postoperative 28th days, 365 days.
Secondary outcomes:
Other outcomes:
Locations:
city: Seoul
country: Korea, Republic of
facility: Severance Hospital
Study officials:
References:
citation: Wong LP, Blackley MP, Andreoni KA, Chin H, Falk RJ, Klemmer PJ. Survival of liver transplant candidates with acute renal failure receiving renal replacement therapy. Kidney Int. 2005 Jul;68(1):362-70. doi: 10.1111/j.1523-1755.2005.00408.x.
citation: Wu CC, Yeung LK, Tsai WS, Tseng CF, Chu P, Huang TY, Lin YF, Lu KC. Incidence and factors predictive of acute renal failure in patients with advanced liver cirrhosis. Clin Nephrol. 2006 Jan;65(1):28-33. doi: 10.5414/cnp65028.
citation: Gonwa TA, Mai ML, Melton LB, Hays SR, Goldstein RM, Levy MF, Klintmalm GB. Renal replacement therapy and orthotopic liver transplantation: the role of continuous veno-venous hemodialysis. Transplantation. 2001 May 27;71(10):1424-8. doi: 10.1097/00007890-200105270-00012.
citation: Holt AW, Bierer P, Bersten AD, Bury LK, Vedig AE. Continuous renal replacement therapy in critically ill patients: monitoring circuit function. Anaesth Intensive Care. 1996 Aug;24(4):423-9. doi: 10.1177/0310057X9602400402.
citation: Matsubara S, Okabe K, Ouchi K, Miyazaki Y, Yajima Y, Suzuki H, Otsuki M, Matsuno S. Continuous removal of middle molecules by hemofiltration in patients with acute liver failure. Crit Care Med. 1990 Dec;18(12):1331-8. doi: 10.1097/00003246-199012000-00005.