Clinical trial NCT02173613: Reduction the Duration of Antibiotic Therapy in the Elderly (PROPAGE)
Official title: Reduction of the Duration of Antibiotic Guided by Procalcitonin in Infections Lungs of Hospitalized Elderly: a Randomized
Study type: INTERVENTIONAL
Overall status: TERMINATED
Phase: NA
Conditions: Lung Infection
Keywords: infection lung elderly patients
Lead sponsor: University Hospital, Grenoble
Sponsor class: OTHER
First posted: 2014-06-25
Enrollment: 117
Sex: ALL
Minimum age (years): 80
Standard ages: OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: OTHER

Brief summary: The main objective is to evaluate the interest of the repeated measurement of procalcitonin in patients with pulmonary infection to reduce the duration of antibiotic therapy in comparison with a conventional clinical strategy.


Eligibility criteria: Inclusion Criteria:

* Age ≥ 80 years
* Started antibiotics for a chest infection
* Procalcitonin performed J0 antibiotic treatment
* Person affiliated to the social security

Exclusion Criteria:

* Patients with a documented infection with germs after Listeria spp, Legionella pneumophilia, Mycobacterium tuberculosis
* Patients with a documented infection with a virus or parasite (eg hemorrhagic fever, malaria)
* Patients with endovascular infection associated (endocarditis, pacemaker. Intravascular catheter)
* Patients with lung abscess associated upon entry Patients with a chronic infection associated
* Patients with severe immunosuppression (HIV or transplant)
* Palliative patient
* Death within 24 hours of admission to nursing units.
* Presence of antibiotic treatment for chronic infection.
* Patient under guardianship, curatorship or any other administrative or judicial action or deprivation of the right or freedom
* Patients hospitalized without their consent

Primary outcomes:
measure: Duration of antibiotic therapy
timeFrame: Success of antibiotic therapy within 45 days of inclusion
Secondary outcomes:
Other outcomes:
Locations:
city: Grenoble
country: France
facility: University Hospital Grenoble
state: Rhone Alpes
Study officials:
affiliation: University Clinic of Geriatrics Medicine, Division of Medicine multidisciplinary CHU de Grenoble,
name: Gaetan Gavazzi
role: PRINCIPAL_INVESTIGATOR
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