Clinical trial NCT04857242: Electrical Impedance Tomography Measurements During Apnea Test in Patients With Suspected Brain Death
Official title: Electrical Impedance Tomography Measurements During Apnea Test in Patients With Suspected Brain Death
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Brain Death
Keywords: Apnea testing
Electrical Impedance Tomography
Lead sponsor: Kiskunhalas Semmelweis Hospital the Teaching Hospital of the University of Szeged
Sponsor class: OTHER_GOV
Collaborators: name: Budapest University of Technology and Economics
name: Hochschule Furtwangen University
name: Szeged University
First posted: 2021-04-23
Enrollment: 10
Sex: ALL
Minimum age (years): 18
Maximum age (years): 99
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: DIAGNOSTIC

Brief summary: Apnea testing is the final decisive examination in the strictly regulated process of brain death assessment. There is no standardized method found in the literature for apnea testing except for the inspection of possible spontaneous chest movements. In addition, the test itself lasts for several minutes leading to the collapse of the lungs.

Electrical impedance tomography (EIT) is a non-invasive, real-time monitoring technique, which is suitable for detecting changes in lung volumes during ventilation. With its help, one can examine the spontaneous initiation of inspiration, the development of atelectasis and the reopening of collapsed regions by mechanical ventilation.

Furthermore, the apnea test provides for analysing the effect of changes in pulmonary perfusion on impedance in the absence of noise generated by ventilation.

Detailed description: The aim of the study is to assess the eligibility of electrical impedance monitoring for the detection of possible spontaneous initiations of inspiration during apnea test in patients with suspected brain death. The study could contribute to the opening of new areas in the clinical use of the electrical impedance device. An additional aim is to observe the collapse and the reopening by recruitment manoeuvers of different pulmonary regions.

Eligibility criteria: Inclusion Criteria:

* Patients with suspected brain death undergoing apnea test for detecting the absence of spontaneous breathing

Exclusion Criteria:

* age under 18
* pregnancy
* pulmonectomy, lung resection in the past medical history
* clinically end stage chronic obstructive pulmonary disease (COPD)
* severe hemodynamic instability (vasopressor refractory shock)
* severe bullous emphysema and/or spontaneous pneumothorax in the past medical history
* chest drainage in situ due to pneumothorax and/or bronchopleural fistula

Primary outcomes:
measure: detection of spontaneous inspiration
timeFrame: 20 minutes
Secondary outcomes:
measure: Gas exchange
timeFrame: 20 minutes
measure: Dynamic compliance
timeFrame: 20 minutes
measure: End expiratory lung impedance
timeFrame: 20 minutes
measure: Center of ventilation
timeFrame: 20 minutes
measure: Lung perfusion
timeFrame: 20 minutes
Other outcomes:
Locations:
city: Szeged
country: Hungary
facility: University of Szeged
Study officials:
References: