Clinical trial NCT05714813: Circuit Training and Retina
Official title: Circuit Resistance Training and Retinal Vascular Changes in Older Persons
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Cognitive Impairment, Progressive
Cerebral Small Vessel Diseases
Keywords: Circuit Resistance Training
High-velocity Training
Retinal Microvasculature
Cognitive Function
Lead sponsor: University of Miami
Sponsor class: OTHER
First posted: 2023-02-06
Enrollment: 40
Sex: ALL
Minimum age (years): 65
Maximum age (years): 90
Standard ages: OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The purpose of this research study is to see if high-speed weight training performed in a circuit (using one machine after another) can improve participant heart and brain function, strength, and power in older persons.


Eligibility criteria: Inclusion Criteria:

1. 65-90 years of age;
2. Montreal Cognitive Assessment (MoCA) \> 23
3. no memory loss complaints

Exclusion Criteria:

1. Uncontrolled cardiovascular or neuromuscular diseases that prevent participation in a training program;
2. Cerebrovascular disease;
3. Malignancy within the previous 5 years;
4. Documented HIV infection or other immunodeficiency syndrome;
5. Any systemic inflammatory or autoimmune conditions such as rheumatoid arthritis, systemic lupus erythematosus, or other serious concomitant medical illness;
6. A history of ocular surgeries (except for cataract surgery more than 6 months ago) or other ocular diseases;
7. Bilateral moderate or severe cataracts;
8. Refractive errors of myopia, hyperopia and/or astigmatism more than 6.0 Diopters.

Primary outcomes:
measure: Change in retinal vessel density as measured by Optical Coherence Tomography Angiography (OCTA)
timeFrame: Baseline, 24 weeks
Secondary outcomes:
measure: Change in Event Memory as measured by the Picture Sequence Memory Test
timeFrame: Baseline, 24 weeks
measure: Change in Information Sorting as measured by the NIH List Sorting Test
timeFrame: Baseline, 24 weeks
measure: Change in Reaction Time for a Mental Task as measured by the NIH Pattern Comparison Processing Speed Test
timeFrame: Baseline, 24 weeks
measure: Change in Dynamic Balance as measured by the Timed Up-and-Go test
timeFrame: Baseline, 24 weeks
measure: Change in the Ability to perform Daily Activities as measured by the Physical Performance Test
timeFrame: Baseline, 24 weeks
measure: Change in Recall and Recognition as measured by the Hopkins Verbal Learning Test
timeFrame: Baseline, 24 weeks
measure: Change in Dual Tasking ability as measured by the Trail Making Test
timeFrame: Baseline, 24 weeks
measure: Change in cardiovascular fitness as measured by the Six-minute walk test.
timeFrame: Baseline, 24 weeks
measure: Change in neuromuscular performance as measured by 1-repetition maximum (1RM)
timeFrame: Baseline, 24 weeks
measure: Change in Concept Switching as measured by the Dimensional Card Sort test.
timeFrame: Baseline, 24 weeks
measure: Change in Congruent and Incongruent Responses as measured by the Flanker test
timeFrame: Baseline, 24 weeks
measure: Change in neuromuscular performance as measured by power production.
timeFrame: Baseline, 24 weeks
Other outcomes:
Locations:
city: Coral Gables
country: United States
facility: Laboratory of Neuromuscular Research and Active Aging
state: Florida
city: Coral Gables
country: United States
facility: Laboratory of Neuromuscular Research and Active Aging
state: Florida
Study officials:
affiliation: University of Miami
name: Joseph F Signorile, PhD
role: PRINCIPAL_INVESTIGATOR
References: