Clinical trial NCT06268132: Longevity in Russia
Official title: Healthy Longevity and Mortality in Long-living Adults: Contributors and Causes - Lifestyle, Socioeconomic Background, and Replicative Aging
Study type: OBSERVATIONAL
Overall status: RECRUITING
Conditions: LONGEVITY 1
Frailty
Aging
Age-related Cognitive Decline
Aging Disorder
Lead sponsor: Center for Strategic Planning, of the Federal Medical and Biological Agency
Sponsor class: OTHER
Collaborators: name: Pirogov Russian National Research Medical University
First posted: 2024-02-20
Enrollment: 4000
Sex: ALL
Minimum age (years): 90
Standard ages: OLDER_ADULT
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: The inclusion of participants will be carried out with the involvement of social services, boarding houses for labor veterans, geriatric centers and other geriatric services in the central region of Russia

Brief summary: This is an observational cohort study of long-living adults (participants aged 90 and above) from the Central Federal District of Russia.

The study seeks to determine the genetic and cellular and molecular determinants of healthy longevity and to assess the impact of lifestyle and socioeconomic and environmental factors on healthy longevity.

The study is expected to result in the development of a panel of markers of healthy longevity and/or a model of healthy aging based on the analysis of all factors under consideration.

Detailed description: The study involves a long-term observation of a cohort of long-living adults. During the first visit, a medical professional will take a detailed medical history and perform a comprehensive geriatric assessment (for 15 geriatric syndromes), and physical examination. The participants will have their biomaterials sampled for basic and extended blood biochemistry testing, telomere length measurement, common urine tests and subsequent biobanking and additional studies: whole genome sequencing, DNA methylation analysis, transcriptome analysis, and 16S RNA sequencing of stool and saliva.

Follow-up checks will be carried out once a year by phone or during additional visits.

The study seeks to identify the genetic, epigenetic, and metagenomic determinants associated with the successful and unsuccessful aging phenotypes, mortality, and survival in long-living individuals.

Eligibility criteria: Inclusion Criteria:

* Informed consent
* 90 years of age or above

Exclusion Criteria:

* Refusal to participate or to provide informed consent;
* Any other criteria deemed reasons for exclusion by the Principal Investigator.

Primary outcomes:
measure: Mortality among long-living adults
timeFrame: at least 1 year after inclusion in the study
measure: Morbidity among long-living adults
timeFrame: at least 1 year after inclusion in the study
Secondary outcomes:
measure: Aging phenotypes
timeFrame: at least 2 years after inclusion in the study
measure: Social, economic, and medical- history-related determinants
timeFrame: at least 2 years after inclusion in the study
measure: Genetic determinants
timeFrame: at least 2 years after inclusion in the study
measure: Epigenetic determinants
timeFrame: at least 2 years after inclusion in the study
measure: Metagenomic determinants
timeFrame: at least 2 years after inclusion in the study
Other outcomes:
Locations:
city: Moscow
country: Russian Federation
facility: RUSSIAN CLINICAL AND RESEARCH CENTER OF GERONTOLOGY, Pirogov Russian National Research Medical University of the Ministry of Healthcare of the Russian Federation
Study officials:
affiliation: Pirogov Russian National Research Medical University
name: Irina D. Strazhesko, M.D., Ph.D
role: PRINCIPAL_INVESTIGATOR
References: