Clinical trial NCT01115413: The Effect of Teenage Maternity on Obstetrical and Perinatal Outcomes
Official title: Influence of Young Maternal Age on Pregnancy Outcome in Central Europe
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Pregnancy
Keywords: teenage
pregnancy
obstetrical risk
Lead sponsor: University of Luebeck
Sponsor class: OTHER
First posted: 2010-05-04
Enrollment: 150
Sex: FEMALE
Minimum age (years): 11
Maximum age (years): 50
Standard ages: CHILD
ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: RETROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: retrospective cohort analysis of all deliveries at the Schleswig-Holstein University Hospital Center in Lübeck from January 2000 through December 2009

Brief summary: The purpose of this study is to estimate the effect of maternal teenage on pregnancy and perinatal outcomes among Caucasian pregnant women.

Detailed description: During the past decade in the United States, approximately 10 percent of teenage girls from 15 to 19 became pregnant. According to the National Vital Statistics Report 2009 seventy of one thousand births in the United States accounted to teenagers from 15 to nineteen years of age during in 2005 and fell to forty per 1,000 women in 2006. In contrary, the overall teenage birth rate lay at twenty- two per 1,000 births in Massachusetts in 2007 ranging from seventy to thirteen per 1,000 women for Hispanic vs. white women aged 15- 19 years. Central European data showed equal results for teenage pregnancy birth rates. According to the German National Institute of Vital Statistics thirty-four of one thousand births in Germany accounted to teenagers younger than 20 years of age. This pattern is a source of concern since teenage mothers have an increased risk of having low-birth- weight babies, premature babies, and babies who die during the first year of life. Additionally, teenage mothers are more likely to suffer from other concomitant pregnancy diseases such as preeclampsia or anemia.

Furthermore, teenage mothers are more likely than older mothers to be poor, less well educated, non- white, unmarried and they are less likely to have received early prenatal care. Dealing with pregnant adolescents therefore means a great challenge in modern obstetrics. Previous research has shown racial differences as well as weight differences for increased risk of adverse prenatal outcome among African Americans and teenagers. Taking into account the impact of race on pregnancy outcomes, our goal was to examine the relationship of young maternal age on obstetrical outcomes in a predominantly Caucasian central European teenaged population.

Eligibility criteria: Inclusion Criteria:

* Nulliparity
* Maternal age of \< 18 years for group A and
* Maternal age \>/= 18 years for group B

Exclusion Criteria:

* Preterm delivery \< 24 + 0 weeks of gestation post menstruation
* Confirmed multiple pregnancy
* Maternal and fetal co morbidity
* Presentation other than cephalic presentation and incomplete data

Primary outcomes:
measure: mode of delivery
timeFrame: 9yrs
Secondary outcomes:
measure: time of labor
timeFrame: 9yrs
measure: maternal injury during labor and delivery
timeFrame: 9yrs
measure: neonatal outcome
timeFrame: 9yrs
Other outcomes:
Locations:
city: Lübeck
country: Germany
facility: Schleswig- Holstein University, Campus Lübeck, Department of Obstetrics and Gynecology
state: Schleswig- Holstein
Study officials:
affiliation: Lübeck University
name: Daniel A Beyer, M.D.
role: PRINCIPAL_INVESTIGATOR
References:
citation: Picklesimer AH, Jared HL, Moss K, Offenbacher S, Beck JD, Boggess KA. Racial differences in C-reactive protein levels during normal pregnancy. Am J Obstet Gynecol. 2008 Nov;199(5):523.e1-6. doi: 10.1016/j.ajog.2008.04.017. Epub 2008 Jun 9.
citation: Steinfeld JD, Valentine S, Lerer T, Ingardia CJ, Wax JR, Curry SL. Obesity-related complications of pregnancy vary by race. J Matern Fetal Med. 2000 Jul-Aug;9(4):238-41. doi: 10.1002/1520-6661(200007/08)9:43.0.CO;2-5.
citation: Woods C. At-risk, pregnant youth and appropriate use of health care. Am Fam Physician. 2010 Mar 1;81(5):577. No abstract available.