louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT01439399: Analgesic Efficacy of Intravenous Lidocaine and/or Ketamine
Official title: Analgesic Efficacy of Intravenous Perfusion of Lidocaine, Ketamine or a Combination After Laparotomy in a Placebo-controlled, Randomized, Double-blind Prospective Study
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Postoperative Pain
Keywords: postoperative pain
postoperative care
intravenous lidocaine
intravenous ketamine
morphine consumption
Lead sponsor: University of Lausanne Hospitals
Sponsor class: OTHER
First posted: 2011-09-23
Enrollment: 52
Sex: ALL
Minimum age (years): 20
Maximum age (years): 75
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The aim of the present study is to evaluate the analgesic benefit of intravenous lidocaine and ketamine in the perioperative period of abdominal surgery.

Detailed description: Optimal postoperative pain management facilitates rehabilitation immediately after abdominal surgery. Multiple studies have demonstrated that successful postoperative analgesia also reduces perioperative complications and improves patient comfort, thereby providing many benefits for the patient. In acute postoperative pain management intravenous lidocaine and/or ketamine have been advocated because of their morphine-sparing effect.

Eligibility criteria: Inclusion Criteria:

* abdominal surgery by laparotomy

Exclusion Criteria:

* laparoscopy
* history of chronic pain
* opioid self-administration
* psychiatric disorders
* difficulties with communication
* renal or hepatic dysfunction
* ASA physical status \> 3

Primary outcomes:
measure: Cumulative morphine consumption
timeFrame: 48 hours
Secondary outcomes:
measure: Pain scores
timeFrame: 48 hours
measure: Mechanical hyperalgesia
timeFrame: 48 hours
measure: Occurrence of side effects
timeFrame: 48 hours
Other outcomes:
Locations:
city: Lausanne
country: Switzerland
facility: University Hospital Center and University
state: Vaud
Study officials:
affiliation: University of Lausanne Hospitals
name: Christian Kern
role: STUDY_DIRECTOR
References:
Clinical trial NCT02450799: Corrected VA With Long-Term Follow-Up After AcrySof® Intraocular Lens (IOL) Implantation
Official title: Corrected VA With Long-Term Follow-Up After AcrySof® IOL Implantation
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Pseudophakia
Lead sponsor: Alcon Research
Sponsor class: INDUSTRY
First posted: 2015-05-21
Enrollment: 104
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NON_RANDOMIZED
Intervention model: PARALLEL

Brief summary: The purpose of this study is to compare the long-term visual acuity (VA) with an acrylic IOL to a silicone or polymethylmethacrylate (PMMA) IOL in cataract patients. This study will take place in Japan.


Eligibility criteria: Inclusion Criteria:

* Willing to provide voluntary consent and able to comprehend and sign the informed consent form;
* Pseudophakic patients implanted with an Acrylic (AcrySof®), PMMA or silicone IOL from 1994 to 2000;
* Clear intraocular media in study eye;
* Best-corrected visual acuity (decimal) within 3 months post-implantation of 0.8 (decimal VA chart) or more in study eye;
* No ocular or systemic condition which may affect visual acuity in study eye;
* Other protocol-specified inclusion criteria may apply.

Exclusion Criteria:

* Complications that may impact visual acuity in study eye at the time of the prospective visit, such as glaucoma, diabetic retinitis, ocular inflammatory disease, retinal detachment, and others as specified in the protocol;
* Previous refractive surgery in study eye;
* Previous IOL exchange in study eye;
* Other protocol-specified exclusion criteria may apply.

Primary outcomes:
measure: Mean Change From Baseline in Best Corrected Visual Acuity (BCVA) at the Long-Term, Post-Implantation Visit
timeFrame: Baseline (up to and including 3 months after implantation), long-term post-implantation visit (14-20 years after implantation)
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
affiliation: Alcon Japan, Ltd.
name: Group Manager, Clinical Dev.
role: STUDY_DIRECTOR
References:
Clinical trial NCT00192699: Bimetric-10: Investigation of Patients Who Have Underwent Total Hip Arthroplasty With a Cemented Bi-Metric Stem
Official title: 10 Year Follow-up Investigation of Patients Who Have Underwent Total Hip Arthroplasty With a Cemented Bi-metric Stem
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Osteoarthrosis
Keywords: Osteoarthritis
Lead sponsor: Northern Orthopaedic Division, Denmark
Sponsor class: OTHER
First posted: 2005-09-19
Enrollment: 80
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: RETROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Patients with osteoarthrosis in hip who have underwent surgery for 10 years ago using Cemented Bi-Metric femoral stem.

Brief summary: This is a 10 year follow-up investigation of patients who have underwent total hip arthroplasty with a cemented Bimetric stem.


Eligibility criteria: Inclusion criteria:

* Osteoarthrosis

Exclusion criteria:

* Malignancies

Primary outcomes:
Secondary outcomes:
Other outcomes:
Locations:
city: Aalborg
country: Denmark
facility: Northern Orthopaedic Division, Aalborg University Hospital
state: Northern Jutland
Study officials:
affiliation: Northern Orthopaedic Division, Aalborg University Hospital, Denmark
name: Mogens B Laursen, MD, PhD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT00895999: Psychosocial Treatment for Women With Depression and Pain
Official title: Psychosocial Treatment for Gynecology Patients With Comorbid Depression and Pain
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Pelvic Pain
Depression
Lead sponsor: University of Rochester
Sponsor class: OTHER
Collaborators: name: National Institute of Mental Health (NIMH)
First posted: 2009-05-11
Enrollment: 60
Sex: FEMALE
Minimum age (years): 18
Maximum age (years): 50
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: Patients with depression and pain have poorer outcomes in response to depression treatments than depressed patients without pain. While psychotherapy treatment studies have demonstrated improvement in pain and depression, no psychosocial interventions have been developed and tested prospectively specifically for patients with both conditions. Interpersonal psychotherapy (IPT), an effective treatment for depression, has been adapted successfully for physically ill patients and demonstrates good adherence, treatment satisfaction, and depression outcomes. The investigators propose to test a modified form of IPT-P for depressed patients with co-morbid pain.


Eligibility criteria: Inclusion Criteria:

* major depression
* chronic pelvic pain

Exclusion Criteria:

* current or past psychosis
* moderate mental retardation or greater
* active suicidal intent
* active abuse of non-prescribed substances (\< 3 months)
* current individual psychotherapy
* current pregnancy
* terminal illness
* inability to communicate in English
* men

Primary outcomes:
measure: A self-report measure BDI and a clinician measure HRSD will evaluate depression severity. These measures are standards in primary care depression trials and in pain studies and have demonstrated sensitivity to detect changes in depress
timeFrame: 0, 12 wks, 24 wks, 36 wks
Secondary outcomes:
Other outcomes:
Locations:
city: Rochester
country: United States
facility: University of Rochester Medical Center
state: New York
Study officials:
affiliation: University of Rochester
name: Ellen Poleshuck, PhD
role: PRINCIPAL_INVESTIGATOR
References:
citation: Poleshuck E, Wittink M, Crean H, Gellasch T, Sandler M, Bell E, Juskiewicz I, Cerulli C. Using patient engagement in the design and rationale of a trial for women with depression in obstetrics and gynecology practices. Contemp Clin Trials. 2015 Jul;43:83-92. doi: 10.1016/j.cct.2015.04.010. Epub 2015 Apr 30.
citation: Poleshuck EL, Gamble SA, Bellenger K, Lu N, Tu X, Sorensen S, Giles DE, Talbot NL. Randomized controlled trial of interpersonal psychotherapy versus enhanced treatment as usual for women with co-occurring depression and pelvic pain. J Psychosom Res. 2014 Oct;77(4):264-72. doi: 10.1016/j.jpsychores.2014.07.016. Epub 2014 Jul 26.
Clinical trial NCT01765699: Predicting Poor Outcomes After Primary Knee Arthroplasty
Official title: Predicting Poor Outcomes After Primary Knee Arthroplasty
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Osteoarthritis, Knee
Lead sponsor: Newcastle-upon-Tyne Hospitals NHS Trust
Sponsor class: OTHER
Collaborators: name: DePuy Orthopaedics
First posted: 2013-01-10
Enrollment: 1300
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Time perspective: RETROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Patients who have undergone primary knee arthroplasty in our centre.

Brief summary: Aim To identify through data analysis key patients, surgeon and operative dependent variables which will improve the performance of knee replacement for primary osteoarthritis

Research Question

1. Can the investigators identify association between outcomes and patients characteristics using existing (already collected) datasets
2. What are the characteristics of patients with poor outcome after knee replacement
3. What can be done to improve the outcome of patients at risk of poor results

Detailed description: This is a retrospective analysis of a prospectively collected single centre database.

Eligibility criteria: Inclusion Criteria:

* Primary knee arthroplasty
* Osteoarthritis

Exclusion Criteria:

* No consent for joint registry data collection

Primary outcomes:
measure: Change in PROMS
timeFrame: 1,2,3 and 5 Years post op
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
affiliation: Consultant Orthopaedic Surgeon
name: Craig Gerrand
role: PRINCIPAL_INVESTIGATOR
affiliation: Consultant Orthopaedic Surgeon
name: David Deehan
role: STUDY_DIRECTOR
References:
Clinical trial NCT04689399: Sensitivity and Specificity of SARS-CoV-2 Rapid Antigen Test Compared to RT-PCR Test
Official title: Sensitivity and Specificity of SARS-CoV-2 Rapid Antigen Test Compared to RT-PCR Test
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Covid19
Rapid Antigen Test
SARS-CoV-2
Lead sponsor: Rigshospitalet, Denmark
Sponsor class: OTHER
Collaborators: name: Testcenter Danmark, Statens Serum Institut
name: Copenhagen Emergency Medical Services
First posted: 2020-12-30
Enrollment: 4697
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: NA
Intervention model: SINGLE_GROUP
Intervention model description: Citizens who have booked an appointment and shows up for a COVID-19 test at a Testcenter Denmark test center in the Capital Region are offered to participate in the project.
Primary purpose: DIAGNOSTIC

Brief summary: This project aims to investigate the sensitivity and specificity of the rapid antigen test compared to RT-PCR test performed on samples from the nasopharynx and the anterior nasal cavity and the oropharynx, respectively.

Detailed description: The purpose of the study is to investigate the sensitivity and specificity of correct SARS-CoV-2 test results of nasopharyngeal swabs and swabs swabs from the anterior part of the nose examined by rapid antigen test (Standard Q COVID-19 Ag - test, SD Biosensor INC.) compared with swabs from the oropharynx examined by RT-PCR test among citizens who have booked an appointment for a COVID-19 test in one of Testcenter Denmark's test centers in the Capital Region.

Eligibility criteria: Inclusion Criteria:

* Age \> 18 years
* A booked appointment for a COVID-19 test at one of Testcenter Denmark's test centers in the Capital Region

Exclusion Criteria:

* Previously tested positive for COVID-19
* Non-fluent in Danish

Primary outcomes:
measure: Sensitivity and specificity of the rapid antigen test of COVID-19
timeFrame: It is expected that the required number of participants can be included during approximately one week after t
Secondary outcomes:
measure: Economic analyses
timeFrame: It is expected that the required number of participants can be included during approximately one week after t
measure: PCR analysis on nasopharyngeal swabs
timeFrame: It is expected that the required number of participants can be included during approximately one week after t
Other outcomes:
Locations:
city: Copenhagen
country: Denmark
facility: Christian von Buchwald, MD, DMSc, Professor
Study officials:
References:
Clinical trial NCT00299299: Modelling Internal Hepatic Movement With an External Abdominal Marker
Official title: Modelling Internal Hepatic Movement With an External Abdominal Marker Block for Use With a Real Time Position Monitoring System for Respiratory Gating
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Patients With Liver Metastases From Colorectal Cancer
Lead sponsor: Royal Marsden NHS Foundation Trust
Sponsor class: OTHER
First posted: 2006-03-06
Enrollment: 10
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: 10 RMH patients aged over 18 years with single or multiple hepatic metastases secondary to colorectal cancer. Metastases at other sites will not be an exclusion criterion. WHO performance status 0, 1 or 2.

Brief summary: This study tests the feasibility and reproducibility of patient-specific motion models. These will be used for quantification of safe margin reduction. Patient-specific motion models will be built by post-processing 4D MRI data with non-rigid registration. By comparing these models between visits, model reproducibility will be assessed, and the methodology refined.

Detailed description: The study will use a real time position management (RPM) system for respiratory gating. The RPM system senses the respiration motion of the patient by tracking a pair of reflective markers on a lightweight "marker block" constructed of a synthetic material. This block is placed on the patient's abdomen.

During Radiotherapy, the beam is only switched on at pre-determined phases of respiration. The appropriate phase of respiration is determined by the RPM system. This implies a reliable correlation of external block motion to internal hepatic movement. This correlation is not a simple one, and requires "modeling".

Eligibility criteria: Inclusion Criteria:

* Histologically confirmed adenocarcinoma compatible with primary disease in the colon or rectum
* Aged 18 years or older
* Unequivocal contrast-enhanced CT and/or MRI evidence of malignant single or multiple metastases in the liver, metastases at other sites will not be an exclusion criterion
* WHO performance status 0-2 and life expectancy of at least 12 weeks
* Informed written consent

Exclusion Criteria:

* Pregnancy or breast feeding
* Evidence of ascites
* Patients unable for whatever reason to lie flat
* Patients unable to give fully informed consent
* Age\< 18 years

Primary outcomes:
Secondary outcomes:
Other outcomes:
Locations:
city: Chelsea
country: United Kingdom
facility: Royal Marsden Hospital
Study officials:
affiliation: Royal Marsden HNHS Foundation Trust
name: Dr Diana Tait
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT05295199: The Effect of Progressive Relaxation Exercise on Fatigue and Comfort Level After Major Orthopedic Surgery
Official title: The Effect of Progressive Relaxation Exercise on Fatigue and Comfort Level After Major Orthopedic Surgery
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Orthopedic Surgery
Lead sponsor: Aksaray University
Sponsor class: OTHER
First posted: 2022-03-25
Enrollment: 60
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: SUPPORTIVE_CARE

Brief summary: This study was planned to determine the effect of progressive relaxation exercise to be applied after major orthopedic surgery on post-operative fatigue and comfort level.

Detailed description: The symptom of fatigue causes tension, anxiety, fear, and insomnia in the person. Fatigue also negatively affects the comfort level of the patient along with the symptoms experienced in individuals.Suggestions and evaluations of the professional healthcare team, especially nurses, are of great importance in the effective fight against fatigue of patients.In this study, it is carried out to determine the effect of progressive relaxation exercise applied after major orthopedic surgery on fatigue and comfort level.

Hypothesis

H1: Progressive relaxation exercise to be applied after major orthopedic surgery reduces the post-operative fatigue level of patients.

H2: Progressive relaxation exercise to be applied after major orthopedic surgery positively affects the comfort level of the patients.

Eligibility criteria: Inclusion Criteria:

* The patients included in the study have undergone major orthopedic surgery (total knee or hip replacement, atroscopic surgery, vertebral surgery, shoulder surgery, amputation, etc.), Patients aged 18 and over Absence of speech and hearing problems Speak and understand Turkish

Exclusion Criteria:

* Being diagnosed with a psychiatric disorder, A complication developed in the patients before, during and three days after the operation,

Primary outcomes:
measure: General Comfort Scale
timeFrame: 1st day after surgery
measure: Postoperative Fatigue Scale
timeFrame: 1st day after surgery
Secondary outcomes:
measure: General Comfort Scale
timeFrame: 4th day after surgery
measure: Postoperative Fatigue Scale
timeFrame: 4th day after surgery
Other outcomes:
Locations:
city: Aksaray
country: Turkey
facility: Aksaray University
Study officials:
affiliation: Aksaray University
name: Funda CETINKAYA
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT02177799: Surveillance Study of Acute Gastroenteritis in Hospitalized Children in Rural Area in Lebanon
Official title: Surveillance Study of Acute Gastroenteritis in Hospitalized Children
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Acute Gastroenteritis
Diarrhea
Rotavirus
Keywords: Gastroenteritis
Hospitalized
Children
Lead sponsor: Shaikh Ragheb Harb Hospital
Sponsor class: OTHER
First posted: 2014-06-30
Enrollment: 150
Sex: ALL
Minimum age (years): 2
Maximum age (years): 10
Standard ages: CHILD
Accepts healthy volunteers: no
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Children male and female from 2 months to 10 year old

Brief summary: Acute gastroenteritis is a common cause of hospitalization in children with significant socioeconomic burden on the health community, we will follow in this observational and analytical study the admitted cases of acute gastroenteritis to the pediatric floor at the Sheikh Ragheb Harb Hospital over a period of summer time to determine the causes, etiologies and epidemiology of Age in a community hospital.

Detailed description: In this survey of hospitalized cases of acute gastroenteritis, children between two months and up to ten years old are included except for known cases of chronic diarrhea, malnutrition or immunodeficiency, data collected include clinical signs and symptoms, epidemiologic information and laboratory data during the hospital stay, also hospital treatment will be reviewed to determine the therapeutic options available in our country and its convenience with the disease and clinical conditions.

Eligibility criteria: Inclusion Criteria:

* children with acute gastroenteritis admitted to the pediatric floor

Exclusion Criteria:

* chronic diarrhea or Immunodeficiency

Primary outcomes:
measure: Age distribution
timeFrame: one year after completing data collection
Secondary outcomes:
Other outcomes:
Locations:
city: Nabatieh
country: Lebanon
facility: Sheikh Ragheb Harb Hospital
state: Toul
Study officials:
References:
Clinical trial NCT04608799: The Efficacy of Fycompa (Perampanel) in Children With Epilepsy
Official title: Director of Child Neurology, Department of Pediatrics, National Taiwan University Hospital
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Neurologic Disorder
Lead sponsor: National Taiwan University Hospital
Sponsor class: OTHER
First posted: 2020-10-29
Enrollment: 38
Sex: ALL
Minimum age (years): 0
Maximum age (years): 18
Standard ages: CHILD
ADULT
Accepts healthy volunteers: no
Observational model: CASE_ONLY
Time perspective: RETROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: Patients suffering from epilepsy

Brief summary: Fycompa (Perampanel), a new anti-epileptic drug that uses a new mechanism-AMPA receptor antagonist. Its initial indication is for local or generalized epilepsy in children and adults over 12 years old, but its effectiveness in the treatment of epilepsy in children At present, more evidence is still needed. We will study the effectiveness of Fycompa (Perampanel) in the treatment of epilepsy in children under the age of 18. It is expected that the clinical use of Fycompa (Parampanel) in Taiwan will be able to analyze and study the effectiveness of the clinical use of Fycompa (Parampanel) in the treatment of epilepsy in children, and compare it with foreign reports.


Eligibility criteria: Inclusion Criteria:

* Patients under 18 years of age suffering from epilepsy
* Patients who are taking Paraampanel

Exclusion Criteria:

* Patients who are not in the above age groups and who are not using parampanel

Primary outcomes:
measure: The efficacy of perampanel in young children with drug-resistant epilepsy
timeFrame: 17 years
Secondary outcomes:
Other outcomes:
Locations:
city: Taipei
country: Taiwan
facility: National Taiwan University Hospital
Study officials:
affiliation: National Taiwan University Hospital
name: WangTso Lee, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT04048499: Prevalence and Severity of Colour Vision Deficiency Among Turkish Children
Official title: Prevalence and Severity of Colour Vision Deficiency Among Turkish Children
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: CAD Test; Children's Vision; Colour Assessment; Colour Vision; Turkey
Lead sponsor: Medipol University
Sponsor class: OTHER
First posted: 2019-08-07
Enrollment: 1374
Sex: ALL
Minimum age (years): 6
Maximum age (years): 18
Standard ages: CHILD
ADULT
Accepts healthy volunteers: yes
Observational model: OTHER
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: A total of 1374 children, aged 6-16 years, who attended the ophthalmology department at the Istanbul Medipol University were included in the study.

Brief summary: To evaluate the usability of the Colour Assessment and Diagnosis (CAD) test in children. To determine the prevalence of colour vision deficiency (CVD) among Turkish children, to identify the class of deficiency and to quanify severity of loss.


Eligibility criteria: Inclusion Criteria: children with aged 6-16 years, who attended the ophthalmology department at the Istanbul Medipol University -

Exclusion Criteria:Children with known or current evidence of ocular pathology (other than refractive errors), with history of long term use of medication, previous ocular surgery and those with chronic systemic diseases were excluded from the study

-

Primary outcomes:
measure: Prevalence and Severity of Colour Vision Deficiency among Turkish Children
timeFrame: january 2018-march 2019
measure: the usability of the Colour Assessment and Diagnosis (CAD) test in children
timeFrame: january 2018-march 2019
Secondary outcomes:
Other outcomes:
Locations:
city: Istanbul
country: Turkey
facility: Istanbul Medipol University
Study officials:
References: