louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT05969613: Comparison of Regional Block, Wound Infiltration and Caudal Block for Pain Management in Children
Official title: Comparison of Regional Block, Wound Infiltration and Caudal Block for Post Operative Pain Management in Children Undergoing Inguinal Herniotomy
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Inguinal Hernia
Lead sponsor: King Edward Medical University
Sponsor class: OTHER
First posted: 2023-08-01
Enrollment: 2
Sex: ALL
Minimum age (years): 2
Maximum age (years): 12
Standard ages: CHILD
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: CROSSOVER
Primary purpose: TREATMENT

Brief summary: Comparison of regional block, wound infiltration and caudal block for post operative pain management in participants undergoing inguinal herniotomy.

Detailed description: Investigators are comparing three modalities (regional block, wound infiltration and caudal block), for post operative pain management in participants after inguinal herniotomy.

Eligibility criteria: Inclusion Criteria:

1. •Patients under 13 years of age
2. •Inguinal hernia

Exclusion Criteria:

1. •History of allergy to any drugs used in study documented on history.
2. •Infection at the site of regional, caudal or local infiltration, documented on clinical examination.
3. •Irreducible, obstructed or strangulated hernia, documented on clinical examination.

Primary outcomes:
measure: post operative pain -FLACC Pain sacle
timeFrame: Within 24 hours
measure: post operative pain -Wong-Baker Faces pain scale
timeFrame: Within 24 hours
Secondary outcomes:
Other outcomes:
Locations:
city: Lahore
country: Pakistan
facility: Mayo Hospital
state: Punjab
Study officials:
affiliation: King Edward Medical University
name: Mamoonullah Asmati
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT03426813: Early Mobilization of Patients With Community-acquired Pneumonia
Official title: Is There an Effect of Early Mobilization of Patients With Community-acquired Pneumonia?
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Pneumonia
Keywords: mobilization
physiotherapy
community-acquired pneumonia
Lead sponsor: Regionshospital Nordjylland
Sponsor class: OTHER_GOV
Collaborators: name: Hvidovre University Hospital
First posted: 2018-02-08
Enrollment: 98
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: TREATMENT

Brief summary: Pneumonia is a common health problem.This thesis may clarify whether early mobilization influence the time these patients are hospitalized, whether they are rehospitalized and whether it is possible to reduce the mortality rate.

Detailed description: Pneumonia is a common health problem. More than 100,000 Danes contract pneumonia every year, and around 15,000 of these are hospitalized. The main treatment is antibiotics. An American study indicates that patients who are mobilized early are hospitalized for a shorter period of time. The objective of the thesis is: to determine the effect of mobilization within 24 hours after hospitalization of patients with pneumonia. The result will be number of hospitalization days, rehospitalisation and mortality.

Patients with pneumonia hospitalized in the period 1 September 2012 - 28 February 2013 in the Medical Centre, lung unit 204B at Vendsyssel Hospital will be included in the project. Within the first 24 hours of hospitalization, they will be tested by a physiotherapist and mobilized.

There are significant costs associated with the treatment of patients with pneumonia - both economic costs and human costs. This thesis may clarify whether early mobilization influence the time these patients are hospitalized, whether they are rehospitalized and whether it is possible to reduce the mortality rate.

Eligibility criteria: Inclusion Criteria:

* patients with community-acquired pneumonia

Exclusion Criteria:

* dementia

Primary outcomes:
measure: The number of hospitalization days
timeFrame: 6 months
Secondary outcomes:
measure: Number of rehospitalizations
timeFrame: 6 months after 1st hospitalization
Other outcomes:
measure: Mortality
timeFrame: 6 months after 1st hospitalization
Locations:
city: Hjørring
country: Denmark
facility: North Denmark Hospital
Study officials:
References:
Clinical trial NCT03612713: Influence of Medication on Functional Connectivity
Official title: Influence of Medication on Functional Connectivity
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: EARLY_PHASE1
Conditions: Prescription Drug Abuse (Not Dependent)
Lead sponsor: Yale University
Sponsor class: OTHER
Collaborators: name: National Institute on Drug Abuse (NIDA)
First posted: 2018-08-02
Enrollment: 20
Sex: ALL
Minimum age (years): 18
Maximum age (years): 30
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: CROSSOVER
Primary purpose: BASIC_SCIENCE

Brief summary: This study will assess the effects of acute low-dose opioid administration on functional neuroimaging measures in healthy individuals

Detailed description: This study will assess the effects of acute low-dose opioid administration on functional neuroimaging measures in healthy individuals (N=40, 20 male, 20 female). The objective of this research is to develop an understanding of factors that may influence individual variability on resting state functional connectivity in response to low-dose opioid administration with the longer term aim of understanding addictions vulnerability. Specifically, the proposed pilot research will explore the effects of single dose of oxycodone (15mg) on resting state functional connectivity and other common neuroimaging measures (e.g., diffusion MRI, structural MRI).

Eligibility criteria: Inclusion Criteria:

1. males or females, ages 18-30
2. for women of a child-bearing age, acceptable birth control methods or a negative pregnancy test prior to MRI scanning
3. ability to provide written, informed consent
4. eligibility and willingness to participate in fMRI scanning and to receive oxycodone
5. normal weight, as indicated by a body mass index (BMI) between 18.5 to 25

Exclusion Criteria:

1. current DSM-5 Axis I disorder
2. any psychotropic medication or medication known to interfere with metabolism of opioids
3. medical contraindication to participate in study activities (acute low-dose opioid admin) as determined by study physician
4. known family history (first-degree relative) of opioid-use disorder or alcohol-use disorder
5. not eligible for MRI scanning
6. positive drug screen
7. recent (past 6 months) medical or non-medical opioid-use
8. current or previous chronic pain disorder
9. significant lifetime use of prescription opioids (\>7 days of consecutive medical use or nonmedical use on more than 5 occasions)

Primary outcomes:
measure: Change in Functional Connectivity Following Oxycodone Administration
timeFrame: Change in functional connectivity from initial fMRI scan to follow-up MRI scan, up to 4 weeks.
Secondary outcomes:
Other outcomes:
Locations:
city: New Haven
country: United States
facility: Magnetic Resonance Research Center at The Anlyan Center Yale School of Medicine
state: Connecticut
Study officials:
affiliation: Yale University
name: Sarah Yip, PhD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT01197313: Depression and Quality of Life in Chronic Heart Failure Patients and the Caregivers
Official title: Depression and Quality of Life in Chronic Heart Failure Patients and the Caregivers
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Chronic Heart Failure (CHF)
Anxiety and Depression
Quality of Life (QOL)
Exercise
Keywords: chronic heart failure (CHF); anxiety and depression; quality of life (QOL); exercise
Lead sponsor: National Taiwan University Hospital
Sponsor class: OTHER
First posted: 2010-09-09
Enrollment: 51
Sex: ALL
Minimum age (years): 20
Maximum age (years): 80
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: Anxiety and depression are often present in patients with chronic heart failure (CHF). This study aimed to evaluate the influence of anxiety and depression on the physical function, disability, and quality of life (QOL) in CHF. This study examined the effects of 8-week home-based exercise on these parameters, and investigated the correlations between these outcome changes.


Eligibility criteria: Inclusion Criteria:

* Clinical diagnosis of CHF for more than 6 months (NYHA Classes I-III)
* Medically stable for at least 3 months

Exclusion Criteria:

* Malignancy
* Psychiatric disease, primary neuromusculoskeletal or respiratory diseases that affected the assessment of functional or exercise capacity
* Changes in medication occurred during the study period

Primary outcomes:
measure: Psychologic aspect
timeFrame: 8 weeks
measure: Functional capacity
timeFrame: 8 weeks
measure: Disability level
timeFrame: 8 weeks
measure: Quality of life
timeFrame: 8 weeks
Secondary outcomes:
Other outcomes:
Locations:
city: Taipei
country: Taiwan
facility: National Taiwan University Hospital
Study officials:
affiliation: National Taiwan University Hospital
name: Ying-Tai Wu, Ph.D
role: PRINCIPAL_INVESTIGATOR
References:
citation: Chien CL, Lee CM, Wu YW, Wu YT. Home-based exercise improves the quality of life and physical function but not the psychological status of people with chronic heart failure: a randomised trial. J Physiother. 2011;57(3):157-63. doi: 10.1016/S1836-9553(11)70036-4.
Clinical trial NCT05093413: Olfactory Decision-making and Deprived Sleep
Official title: Olfactory Decision-making and Deprived Sleep
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Sleep Deprivation
Lead sponsor: Northwestern University
Sponsor class: OTHER
First posted: 2021-10-26
Enrollment: 46
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: CROSSOVER
Primary purpose: BASIC_SCIENCE

Brief summary: This research study will use magnetic resonance imaging (MRI) and olfactory stimuli to better understand the connection between sleep deprivation, brain activity, and olfaction in humans.


Eligibility criteria: Inclusion Criteria:

* At least 18 years old
* Fluent English speakers

Exclusion Criteria:

* History of neurological conditions (e.g., epilepsy, dementia, multiple sclerosis, brain tumors, etc.)
* History of psychiatric conditions (e.g., general anxiety disorder, depression, schizophrenia, obsessive-compulsive disorder, post-traumatic stress disorder, attention deficit hyperactivity disorder, alcoholism, etc.)
* Significant medical illnesses (e.g., cancer, meningitis, chronic obstructive pulmonary disease, cardiovascular disease, etc.)
* Cerebrovascular risk factors (e.g., hypertension, diabetes, elevated cholesterol, etc.)
* Use of psychoactive medications (e.g., barbiturates, benzodiazepines, chloral hydrate, haloperidol, lithium, carbamazepine, phenytoin, citalopram, escitalopram, fluoxetine, diazepam, etc.)
* Smell or taste dysfunction
* History of severe allergies requiring hospitalization for treatment
* History of severe asthma requiring hospitalization for treatment
* Habitual smoking
* History of eating disorders (e.g., anorexia nervosa, bulimia nervosa, binge-eating disorder, etc.)
* Dieting or fasting
* History of sleep disorders (e.g., obstructive sleep apnea, narcolepsy, insomnia, etc.) Magnetic implants (e.g., shunts or stents, aneurysm clips, surgical clips, cochlear implants, metal bone/joint pins, plates and screws, eyelid spring or wires, etc.)
* Electronic implants (e.g., implanted cardiac defibrillator, cardiac pacemaker, deep brain/spinal cord or nerve stimulator, internal electrodes/wires, medication infusion devices, etc.)
* History of metal working without proper eye protection, or injury with metal shrapnel or metal slivers
* Left-handedness
* Claustrophobia

Primary outcomes:
measure: Behavior an olfactory perceptual decision-making task
timeFrame: Up to 24 hours after the intervention
Secondary outcomes:
measure: Resting-state functional magnetic resonance imaging
timeFrame: Up to 24 hours after the intervention
Other outcomes:
Locations:
city: Chicago
country: United States
facility: Northwestern University
state: Illinois
Study officials:
affiliation: Associate Professor
name: Thorsten Kahnt, PhD
role: PRINCIPAL_INVESTIGATOR
affiliation: Assistant Professor
name: Christina Zelano, PhD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT03978013: Pomegranate Juice Effect on Oxidative Stress in Infertile Women During IVF Treatment
Official title: Pomegranate Juice Effect on Oxidative Stress in Infertile Women During IVF Treatment
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: PCOS
Endometriosis
Advised Maternal Age
Male Factor Infertility
Lead sponsor: Rambam Health Care Campus
Sponsor class: OTHER
First posted: 2019-06-06
Enrollment: 40
Sex: FEMALE
Minimum age (years): 18
Maximum age (years): 45
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Intervention model description: RCT
Primary purpose: SUPPORTIVE_CARE

Brief summary: tTe investigators estimate pomegranate supplementation effect on oxidative stress in infertile women with PCOS, endometriosis and advanced maternal age during IVF treatment. The primary aim is to compare the obtained oxidative stress markers in follicular fluid with pomegranate supplementation vs control.


Eligibility criteria: Inclusion Criteria:

* Patients undergo IVF treatment with diagnosis of PCOS/Endometriosis/MF or AMA

Exclusion Criteria:

* Patients who do not meet the inclusion criteria, as above

Primary outcomes:
measure: Cytokines levels in follicle fluid
timeFrame: 2 weeks
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
References:
Clinical trial NCT00686413: Positron Emission Tomography Study Using 2-[18F]-F-A85380 to Determine α4β2 Neuronal Nicotinic Receptor Occupancy of AZD3480 After Oral Administration to Healthy Male Subjects
Official title: An Open Label Positron Emission Tomography (PET) Study Using 2-[18F]-F-A85380 to Determine α4β2 Neuronal Nicotinic Receptor Occupancy of AZD3480 After Oral Administration to Healthy Male Subjects (Non Nicotine Users)
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE1
Conditions: Healthy
Keywords: PET
AZD3480
PET examination
Lead sponsor: AstraZeneca
Sponsor class: INDUSTRY
First posted: 2008-05-29
Enrollment: 9
Sex: MALE
Minimum age (years): 20
Maximum age (years): 80
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: NON_RANDOMIZED
Intervention model: SINGLE_GROUP
Primary purpose: TREATMENT

Brief summary: The study is being performed in order to learn more about AZD3480 (potential as treatment for patients with Alzheimer's Disease) and to investigate how much of AZD3480 is bound to the nicotinic receptors in the brain at different concentrations of AZD3480 in blood, as well as to investigate the period of time for this binding.


Eligibility criteria: Inclusion Criteria:

* Physically Healthy volunteers
* Genotyped with regard to CYP2D6
* Normal MRI scan at Visit 2

Exclusion Criteria:

* Known or suspected drug or alcohol abuse or positive drugs of abuse screen as judged by the investigator.
* Participation in a PET examination as part of a scientific study during the past twelve months.
* Prescribed or non-prescribed from two weeks prior to the first PET examination. Occasional paracetamol and nasal spray for congestion will be allowed as medication.

Primary outcomes:
measure: Plasma concentration (AUC, Cmax, tmax)
timeFrame: During time period of the PET assessement
measure: The whole brain uptake and regional distribution of radioligand 2-[18F]-F-A85380 following single intravenous (iv) microdose will be assessed (using derived radioactivity measurements).
timeFrame: One on baseline day and one at the drug treatment day
Secondary outcomes:
measure: SafetyAEs and vital signs.
timeFrame: During the whole study
Other outcomes:
Locations:
city: Stockholm
country: Sweden
facility: Research Site
Study officials:
affiliation: Clinical Neuroscience TA AstraZeneca R&D Södertälje, Sweden
name: Hans-Göran, Hårdemark, MD, PhD
role: STUDY_DIRECTOR
affiliation: AstraZeneca Clinical Pharmacology Unit, C2-84, Karolinska University Hospital Huddinge, Stockholm, Sweden
name: Bo Fransson, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT03416413: Study of Foam Sclerotherapy Versus Ambulatory Phlebectomy
Official title: Randomised Controlled Trial of Foam Sclerotherapy Versus Ambulatory Phlebectomy for the Treatment of Varicose Vein Tributaries
Study type: INTERVENTIONAL
Overall status: RECRUITING
Phase: PHASE4
Conditions: Varicose Veins
Lead sponsor: Imperial College London
Sponsor class: OTHER
First posted: 2018-01-31
Enrollment: 160
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: This study will be comparing the treatment of varicose vein tributaries using either foam sclerotherapy or ambulatory phlebectomies. Patients will be randomised to having either ambulatory phlebectomy (group A) or foam sclerotherapy (group B) following treatment of their saphenous vein.

The re-intervention rates, safety, patient experience as well as the cost effectiveness of each intervention will be assessed.


Eligibility criteria: Inclusion Criteria:

* Adults over 18 years of age
* Symptomatic GSV or SSV vein reflux \> 0.5 seconds on colour Duplex
* Varicose vein tributary requiring treatment

Exclusion Criteria:

* Current DVT
* Recurrent varicose veins
* Arterial disease (ABPI\<0.8)
* Vein diameter \< 3mm
* Preference for one of the treatment options
* Patient who are unwilling to participate
* Inability or unwillingness to complete questionnaires
* Inability to attend follow-up appointments
* Patient currently included in a study of varicose vein treatment

Primary outcomes:
measure: Re-intervention rate
timeFrame: 12 months
Secondary outcomes:
measure: Generic quality of life score
timeFrame: 12 months
measure: Disease-specific quality of life score
timeFrame: 12 months
measure: Disease specific quality of life score
timeFrame: 12 months
measure: Clinical score
timeFrame: 12 months
measure: Clinical score
timeFrame: 12 months
measure: Pain score over the first 10 days
timeFrame: 2 weeks
measure: Degree of bruising at 2 weeks
timeFrame: 2 weeks
measure: Time to return to normal activities
timeFrame: 2 weeks
Other outcomes:
Locations:
city: London
country: United Kingdom
facility: Charing Cross Hospital, Imperial College London
Study officials:
References:
citation: Belramman A, Bootun R, Lane TRA, Davies AH. Foam sclerotherapy versus ambulatory phlebectomy for the treatment of varicose vein tributaries: study protocol for a randomised controlled trial. Trials. 2019 Jul 3;20(1):392. doi: 10.1186/s13063-019-3398-0.
Clinical trial NCT03741413: The Effect of Message Framing on Blood Donation-Study 1
Official title: Saving a Life or Preventing a Death: the Effect of Message Framing on Blood Donation Among Rh Negative Donors
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Rh Negative Blood Donor
Lead sponsor: Guangzhou Blood Center
Sponsor class: OTHER_GOV
First posted: 2018-11-14
Enrollment: 2074
Sex: ALL
Minimum age (years): 18
Maximum age (years): 60
Standard ages: ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: HEALTH_SERVICES_RESEARCH

Brief summary: Rh negative blood group is a rare blood group in China, as it only accounts for 0.3-0.4 percent of the Han population. Therefore, low inventory is often found in blood collection and supply agencies in many regions in China. On July 18, 2018 blood stockpile of O-negative and B-negative in Guangzhou Blood Center reached the warning line, and we took measures for emergency recruitment. O-negative and B-negative blood donors whose last donation dates were between January 1, 2015 and December 31, 2017 were identified and randomly assigned to three groups. Three different recruitment text messages were send to these groups respectively. At the same time, A-negative and AB-negative blood donors were marked as control group. We observed the re-donation rates among four groups within three months.


Eligibility criteria: Inclusion Criteria:

* Rh- negative blood donors whose last donations were between January 1, 2015 and December 31, 2017.

Exclusion Criteria:

* Donors with an obviously invalid phone number. Donors whose serological results of the last donation were positive.

Primary outcomes:
measure: Re-donation rate
timeFrame: 3 months
Secondary outcomes:
Other outcomes:
Locations:
city: Guangzhou
country: China
facility: Guangzhou Blood Center
state: Guangdong
Study officials:
References:
Clinical trial NCT06583213: Conventional Spinal Anaesthesia Versus Fractional Spinal Anaesthesia on Hemodynamics
Official title: Comparative Study Between Conventional Spinal Anaesthesia and Fractional Spinal Anaesthesia on Systemic Haemodynamics in Frail Elderly Hip Fracture Patients
Study type: INTERVENTIONAL
Overall status: RECRUITING
Phase: NA
Conditions: Hip Fractures
Keywords: fractional spinal
Lead sponsor: Ain Shams University
Sponsor class: OTHER
First posted: 2024-09-03
Enrollment: 40
Sex: ALL
Minimum age (years): 60
Maximum age (years): 100
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: PREVENTION

Brief summary: compare the systemic haemodynamic response to fractional spinal anaesthesia versus conventional spinal anaesthesia , in a group of elderly and comorbid patients with hip fracture.

Detailed description: Spinal anaesthesia affects sympathetic chain activity, leading to a reduction in vasomotor tone.It was found that the incidence of hypotension following single-shot spinal anaesthesia, has previously been described as being 28-69%. As a matter of fact, autonomic nervous system function plays a key role in the development of haemodynamic instability and intraoperative hypotension . Haemodynamic stability should be considered as a primary intraoperative target, since several findings suggest avoiding systemic pressure drops . It was found that hypotension is primarily related to the overall dose injected ; however, several other variables, including the volume, the type of the anaesthetics injected, different adjuvant agents, and pre- and intraoperative factors, may impact the haemodynamic effect of the SA.

Eligibility criteria: Inclusion Criteria:

* Patients with hip fractures.
* Patients age \>60 years old.
* ASA ≤ 3.

Exclusion Criteria:

* Patients on anticoagulant medication.
* Planned for general anaesthesia .
* Patients had atrial fibrillation.

Primary outcomes:
measure: Is to measure blood pressure change intra-operative operative operative (2 hours)
timeFrame: 2 hours
Secondary outcomes:
measure: Postoperative pain score for 24 hours
timeFrame: within 24 hours
Other outcomes:
Locations:
city: Cairo
country: Egypt
facility: Ain Shams University
Study officials:
affiliation: Ain Shams University
name: ahmed saudi, professor
role: STUDY_DIRECTOR
References: