Clinical trial NCT06359977: The Effect of Quantitative EEG Combined With Ultrasound and Sputum Volume on Predicting Weaning Failure
Official title: The Effect of Quantitative Electroencephalography Combined With Ultrasound and Sputum Volume on Predicting Weaning Failure in Neurocritical Patients
Study type: OBSERVATIONAL
Overall status: NOT_YET_RECRUITING
Conditions: Weaning Failure
Keywords: Quantitative Electroencephalography
ultrasound
Lead sponsor: Qingdao University
Sponsor class: OTHER
First posted: 2024-04-11
Enrollment: 50
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: CASE_ONLY
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: The population in this study focused on neurocritical patients with endotracheal intubation. The data of quantitative EEG, beside ultrasound and sputum volume are all recorded for predicting weaning failure.

Brief summary: Neurocritical patients often face the need for removal of endotracheal tubes. However, despite following the extubation criteria for general critical ill patients, neurocritical patients still exhibit a higher rate of weaning failure, significantly higher than that of general critical ill patients. The extubation criteria for general critical patients emphasize the assessment of lung conditions. However, neurological critical patients often have less severe lung damage, but factors such as consciousness level and coughing ability may significantly influence extubation. Quantitative EEG serves as an objective tool to reflect consciousness level status, while bedside ultrasound can assess respiratory muscle function. Additionally, sputum volume may reflect the condition of lung condition. Therefore, we believe that combination of these three indicators can better predict the success of extubation for neurocritical patients.


Eligibility criteria: Inclusion Criteria:

* Neurocritical patients with endotracheal intubation;
* Successful spontaneous Breathing Trial;
* The patients meet extubation criteria evaluated by clinical physician

Exclusion Criteria:

* Patients whose families have opted for cessation of treatment.

Primary outcomes:
measure: Quantitative EEG indicators
timeFrame: 2 hours before extubation
measure: Respiratory muscles thickness in centimeter
timeFrame: 2 hours before extubation
measure: Respiratory muscles thickening fraction (%)
timeFrame: 2 hours before extubation
measure: Sputum volume in milliliter
timeFrame: 24 hours before extubation
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
affiliation: The Affiliated Hospital of Qingdao University
name: bo yao, Dr.
role: PRINCIPAL_INVESTIGATOR
References:
citation: Welte TM, Gabriel M, Hopfengartner R, Rampp S, Gollwitzer S, Lang JD, Stritzelberger J, Reindl C, Madzar D, Sprugel MI, Huttner HB, Kuramatsu JB, Schwab S, Hamer HM. Quantitative EEG may predict weaning failure in ventilated patients on the neurological intensive care unit. Sci Rep. 2022 May 4;12(1):7293. doi: 10.1038/s41598-022-11196-7.
citation: Bosel J. Who Is Safe to Extubate in the Neuroscience Intensive Care Unit? Semin Respir Crit Care Med. 2017 Dec;38(6):830-839. doi: 10.1055/s-0037-1608773. Epub 2017 Dec 20.