Clinical trial NCT04353947: Induction and Recognition of Emotions
Official title: Induction and Recognition of Emotions in Healthy Older Adults, Alzheimer's Disease and Parkinson's Disease
Study type: OBSERVATIONAL
Overall status: WITHDRAWN
Conditions: Healthy Older Adults
Alzheimer's Disease
Parkinson's Disease
Keywords: Healthy older adults
Alzheimer's disease
Parkinson's disease
Mood induction
Positive emotions
Negative emotions
Lead sponsor: University of Valencia
Sponsor class: OTHER
Collaborators: name: Asociación Parkinson Valencia
First posted: 2020-04-21
Enrollment: 0
Sex: ALL
Minimum age (years): 65
Maximum age (years): 99
Standard ages: OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: COHORT
Time perspective: CROSS_SECTIONAL
Sampling method: NON_PROBABILITY_SAMPLE
Study population: * Healthy older adults will be recruited from the Third Age Classrooms of the municipality of Quart de Poblet.
* The older adults with mild Alzheimer's disease will be recruited through the Neurology Department of the General Hospital of Valencia.
* The older adults with Parkinson's disease will be recruited through the Valencia Parkinson Association.

Brief summary: This study evaluates the differences in cognitive function between healthy older adults, older adults with mild Alzheimer's type dementia and older adults with Parkinson's disease and if there are differences in valence assessment and activation that produce them a mood induction task. Subjects are assessed using neuropsychological tests and then a mood induction task based on movie clips is applied.

Detailed description: Different neuropsychological tests will be used to assess the differences in cognitive function in the different groups, whose scores are expected to be lower in the group of older adults with Alzheimer's disease (AD) and older adults with Parkinson's disease (PD).

After studying the cognitive function in the different groups, we proceed to check through a task based on movie clips if there are also differences in the valence assessment (liking/disliking depending on the emotion induced by scenes from different films) and activation (excitement caused by each one of the movie scenes), hoping to find differences for the negative emotions taking into account the cognitive difficulties that both (the EA group and the EP group) may have for processing this type of cognitively more demanding information; instead, it is possible that the positivity effect continues to affect these patients so that for positive emotions there are no differences between the different groups.

Eligibility criteria: Inclusion Criteria:

For the group of healthy older adults:

* MEC score greater than 26 points.
* GDS between 1 and 3.

For the mild EA group:

* MEC score between 18 and 23 points.
* GDS between 3 and 4.

For the EP group:

* MEC score greater than 23 points.
* GDS between 1 and 3.
* FAB score equal to or less than 11 points.

General Exclusion Criteria:

Participants cannot have:

* Significant asymptomatic neurovascular disease
* History of previous symptomatic stroke
* Alcohol or drug abuse/dependence
* Severe psychiatric symptoms
* Depressive symptoms higher than mild

Primary outcomes:
measure: Mini-Mental State Examination (MMSE)
timeFrame: 5-10 minutes
measure: Beck Depression Inventory-II (BDI-II)
timeFrame: 5-10 minutes
measure: Global Deterioration Scale (GDS)
timeFrame: 30 minutes
measure: Memory alteration test (M@T)
timeFrame: 5-10 minutes
measure: Spanish-Complutense Verbal Learning Test (TAVEC)
timeFrame: 30 minutes
measure: Barcelona test (BT)
timeFrame: 5 minutes
measure: Rey-Osterrieth Complex Figure Test (ROCFT)
timeFrame: 10 minutes
measure: Frontal assessment battery (FAB)
timeFrame: 10 minutes
measure: Positive and Negative Affect Scale (PANAS)
timeFrame: 10 minutes
measure: Auto-Assessment Manikins (SAM)
timeFrame: 5-10 minutes
Secondary outcomes:
Other outcomes:
Locations:
city: Valencia
country: Spain
facility: University of Valencia
Study officials:
affiliation: University of Valencia
name: Juan C Melendez, Psychology
role: PRINCIPAL_INVESTIGATOR
References:
citation: Fernandez-Aguilar L, Ricarte J, Ros L, Latorre JM. Emotional Differences in Young and Older Adults: Films as Mood Induction Procedure. Front Psychol. 2018 Jul 3;9:1110. doi: 10.3389/fpsyg.2018.01110. eCollection 2018.
citation: Carvalho S, Leite J, Galdo-Alvarez S, Goncalves OF. The Emotional Movie Database (EMDB): a self-report and psychophysiological study. Appl Psychophysiol Biofeedback. 2012 Dec;37(4):279-94. doi: 10.1007/s10484-012-9201-6.
citation: Alves H, Koch A, Unkelbach C. Why Good Is More Alike Than Bad: Processing Implications. Trends Cogn Sci. 2017 Feb;21(2):69-79. doi: 10.1016/j.tics.2016.12.006. Epub 2017 Jan 4.
citation: Alves H, Koch A, Unkelbach C. The differential similarity of positive and negative information - an affect-induced processing outcome? Cogn Emot. 2019 Sep;33(6):1224-1238. doi: 10.1080/02699931.2018.1549022. Epub 2018 Nov 26.
citation: Reed AE, Carstensen LL. The theory behind the age-related positivity effect. Front Psychol. 2012 Sep 27;3:339. doi: 10.3389/fpsyg.2012.00339. eCollection 2012.
citation: Nashiro K, Mather M. Effects of emotional arousal on memory binding in normal aging and Alzheimer's disease. Am J Psychol. 2011 Fall;124(3):301-12. doi: 10.5406/amerjpsyc.124.3.0301.