Clinical trial NCT01553552: Schistosomiasis Effect on Response to Vaccines, Anaemia and Nutritional Status of Children of Northern Senegal
Official title: Comparison of Schistosomiasis Diagnostic Techniques and Study of Schistosoma Infection on Children's Immune Response to Childhood Vaccines, on Anaemia and on Nutritional Status
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Schistosomiasis
Anemia
Underweight
Stunting
Intestinal Parasites
Keywords: Schistosoma haematobium
schistosoma mansoni
Anemia
Underweight
stunting
Blastocystis
Lead sponsor: Biomedical Research Center EPLS
Sponsor class: OTHER
Collaborators: name: Institut Pasteur de Lille
name: University of Lille Nord de France
name: Région Nord-Pas de Calais, France
name: Centre d'Infection et d'Immunité de Lille
name: Centre National de la Recherche Scientifique, France
name: Institut National de la Santé Et de la Recherche Médicale, France
First posted: 2012-03-14
Enrollment: 99
Sex: ALL
Minimum age (years): 6
Maximum age (years): 10
Standard ages: CHILD
Accepts healthy volunteers: yes
Observational model: CASE_CONTROL
Time perspective: CROSS_SECTIONAL
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Residents of 3 villages from the Senegal Valley River, belonging to the Podor District in Saint-Louis Region in Northern Senegal: Agniam Towguel, Fanaye Diery and Niandane. Subcohort of a previous study "AnoPalAnoVac" (ClinicalTrials.gov ID: NCT01545115)

Brief summary: SchistoVAN aims to study the role of schistosomiasis infection in the modulation of the immune response of children to childhood vaccine antigens, as well as the impact of this infection on their nutritional status and their haemoglobinaemia.

Detailed description: SchistoVAN aims to study the interactions between chronic parasite infections such as schistosomiasis and the immunological and nutritional status of children. In this scope, the investigators conducted a case-control study where one group of children is infected with schistosoma haematobium and the other is not infected with this parasite.

The investigators then stimulated whole blood of these children with various vaccine antigens to address their immune function and study the influence of schistosomiasis infectious state on their overall immune condition.

Aims of the study:

To evaluate the interaction between schistosomiasis and the nutritional status of children and their haemoglobinemia.

To evaluate the influence of schistosomiasis on children's specific immune response towards EPI vaccine antigens, the inflammatory status of children and nutritional serologic markers.

To compare schistosomiasis diagnostic tools (evaluation of circulating cathodic antigen (CCA) strip for diagnosis of urinary schistosomiasis in comparison with microscopy and urinary dipsticks)

To study prevalence of intestinal parasites such as Blastocystis hominis

Eligibility criteria: Inclusion Criteria:

* Members of AnoPalAnoVac cohort
* Age: between 6 and 10 years

Exclusion Criteria:

* body temperature \> 38.5 ºC
* malaria episode

Primary outcomes:
Secondary outcomes:
Other outcomes:
Locations:
city: Saint-Louis
country: Senegal
facility: Biomedical Research Center EPLS
state: SL
Study officials:
affiliation: Biomedical Research Center EPLS
name: Emmanuel Hermann, PhD A.Pr.
role: STUDY_CHAIR
affiliation: Biomedical Research Center EPLS
name: Lobna Gaayeb, VetMed
role: STUDY_DIRECTOR
affiliation: Biomedical Research Center EPLS
name: Modou Seck, MD
role: PRINCIPAL_INVESTIGATOR
References:
citation: Hermann E, Gaayeb L, Sow PS, Seck M, Sagna AB, Senghor S, Bandagny L, Brinkhuizen C, Delcroix-Genete D, Schacht AM, Riveau G. Sex-dependent interactions between leptin, wasting and humoral immunity in two ethnic communities of school-aged children differentially exposed to Schistosoma haematobium. Trans R Soc Trop Med Hyg. 2017 Oct 1;111(10):448-456. doi: 10.1093/trstmh/trx078.