louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT05944341: Articaine Efficiency in Pulpectomy of Children With Irreversible Pulpitis Under the Age of Four
Official title: Articaine Success in Pulpectomy of Primary Molars With Irreversible Pulpitis in Children Under Four Years: a Randomized Controlled Trial
Study type: INTERVENTIONAL
Overall status: RECRUITING
Phase: NA
Conditions: Dental Pulp Diseases
Lead sponsor: Minia University
Sponsor class: OTHER
First posted: 2023-07-13
Enrollment: 164
Sex: ALL
Minimum age (years): 36
Maximum age (years): 47
Standard ages: CHILD
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: OTHER

Brief summary: A two-tailed randomized controlled trial with two parallel arms is aimed to compare success proportions of the articaine and lidocaine groups in children with irreversible pulpitis under 4 years. The participants will be randomly assigned into two equal groups (82 children per group): the control group will receive lidocaine and the intervention group will receive the articaine local anesthesia.

The direct observation tool FLACC was considered to assess pain severity. The behavior was assessed during pulpectomy procedures using the Frankl behavior rating scale (FBRS)


Eligibility criteria: Inclusion Criteria:

* Healthy 36-47 month-children (ASA class I or II) weighing at least 15 kilograms
* Children should be intellectually fit, and cooperative, with no behavior or communication abnormalities
* Presence of a carious maxillary or mandibular second primary molars with signs and symptoms of irreversible pulpitis

Exclusion Criteria:

* Molars with unrestorable crowns
* Molars with necrotic pulps, pathological mobility, gingival swelling or abscess, fistulous or sinus tract, or apical periodontitis

Primary outcomes:
measure: Face, Legs, Activity, Cry, Consolability pain scale
timeFrame: up to 24 hours
Secondary outcomes:
Other outcomes:
Locations:
city: Al Minyā
country: Egypt
facility: Ahmad Elheeny
state: Al Minya
Study officials:
References:
Clinical trial NCT00969241: The Effect of Periodontal Treatment on the Level of Free Radicals in the Saliva
Official title: The Effect of Periodontal Treatment on the Level of Free Radicals in the Saliva
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Periodontitis
Keywords: saliva
free-radicals
periodontitis
Lead sponsor: The Baruch Padeh Medical Center, Poriya
Sponsor class: OTHER_GOV
First posted: 2009-09-01
Enrollment: 30
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: CASE_CONTROL
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Patients with periodontitis who visit the department and volunteers.

Brief summary: This study will examine the relationship between free radicals in the saliva and periodontitis. 30 adults, 15 with periodontitis and 15 as a control group will give a sample of saliva before treatment and after treatment. The investigators will examine the free radicals in both groups.

Detailed description: Periodontal disease is a chronic adult condition. Bacteria implicated in the etiology of this disease causes destruction of connective tissue and bone. As a result of stimulation by bacterial antigen PMN produces free radicals via respiratory burst as a part of host response to infection.

Free radicals can be defined as molecules or molecular fragments with an unpaired electron which imparts certain characteristics to the free radicals such as reactivity . Reactive free radicals are able to produce chemical modifications and to damage proteins, lipids, carbohydrates and nucleotides in the tissues.

Eligibility criteria: Inclusion Criteria:

* older than 18
* no medical problems

Exclusion Criteria:

* medical problems

Primary outcomes:
Secondary outcomes:
Other outcomes:
Locations:
city: Tieberia, Israel
country: Israel
facility: department of oral and maxillofacial surgery, Baruch Padeh Medical Center
state: Poria
Study officials:
affiliation: department of oral and maxillofacial surgery
name: eran front, Dr.
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT04979741: Recovery After Intensive Care Study
Official title: Recovery After Intensive Care Study: a Single- Center Observational Study
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Follow up
Outcome
Intensive Care Unit Syndrome
Keywords: intensive care unit
cognitive dysfunction
delirium
Lead sponsor: University of Genova
Sponsor class: OTHER
First posted: 2021-07-28
Enrollment: 196
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Patients admitted to the ICU from more than 72 hours will be consecutively included during a 2 years period

Brief summary: Post-ICU long term sequelae- defined as "post intensive care syndrome" (PICS) manifest with a wide spectrum of psychological and cognitive impairments, affecting over two-thirds of ICU survivors and leading to increased rehospitalization, health care costs, impaired quality of life (QoL), inability to return to work and burden for families.

The prevalence of post-traumatic stress symptoms (PTSD), anxiety symptoms, and depression after ICU stay is high and has been demonstrated in up to 50% of post-ICU population.

Therefore, over the last years, an important effort has been made for the development of ICU aftercare and follow-up clinics with the aim to detect and to minimize post-ICU sequelae and improve outcomes. However, the utility of these follow-up programs and their effect on outcome has not been completely demonstrated.

Detailed description: This is a single center, prospective observational study, which will be conducted at Policlinico San Martino Hospital, Genova, Italy. Patients admitted to the ICU from more than 72 hours will be consecutively included during a 2 years period.

The primary objective is to assess the incidence of post-discharge mortality in patients admitted in ICU at 12 months.

Secondary objectives include the evaluation at 3, 6 and 12 months of outcome of patients admitted in ICU assessing QoL, anxiety, depression, PTSD, physical ability, cognitive function, sleep disorder and return to previous life; Self- and observer reported cognitive disability at 6 and 12 months after ICU discharge; prognostic factors for poor outcome, and emotional and burden of care impact on the patient's caregivers.

Eligibility criteria: Inclusion Criteria:

* Age ≥ 18 years;
* All patients acutely admitted in the ICU from \>72 hours, for both medical and surgical pathologies.

Exclusion Criteria:

* Pregnancy;
* Refuse of consent to enrolment of patient or of the doctor required to give his approval.

Primary outcomes:
measure: To assess the incidence of post-discharge mortality in patients admitted in ICU.
timeFrame: 12 months
Secondary outcomes:
measure: Cognitive outcome assessed through the MoCA scale, Montreal Cognitive Assessment
timeFrame: 12 months
measure: Cognitive outcome assessed through HADS scale (Hospital Anxiety and Depression Scale)
timeFrame: 12 months
Other outcomes:
Locations:
city: Genova
country: Italy
facility: Policlinico San Martino
Study officials:
References:
Clinical trial NCT05904041: E-health Literacy and Healthy Lifestyle Behaviors of University Students Studying Health Education in Turkey
Official title: Relationship Between E-health Literacy and Healthy Lifestyle Behaviors of University Students Studying Health Education in Turkey
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: E-health Literacy
Healthy Lifestyle Behaviors
Lead sponsor: KTO Karatay University
Sponsor class: OTHER
First posted: 2023-06-15
Enrollment: 1454
Sex: ALL
Minimum age (years): 17
Maximum age (years): 27
Standard ages: CHILD
ADULT
Observational model: OTHER
Time perspective: CROSS_SECTIONAL
Sampling method: NON_PROBABILITY_SAMPLE
Study population: University students

Brief summary: The aim of this study is to examine the relationship between e-health literacy and healthy lifestyle behaviors of university students receiving health education in Turkey.


Eligibility criteria: Inclusion Criteria:

* Volunteering to participate in the study,
* being at least an associate degree student in the study area of health education

Exclusion Criteria:

* having any vision and hearing problems

Primary outcomes:
measure: E-health literacy
timeFrame: baseline
measure: Healthy lifestyle behavior
timeFrame: baseline
Secondary outcomes:
Other outcomes:
Locations:
city: Konya
country: Turkey
facility: KTO Karatay University
state: Karatay
Study officials:
References:
Clinical trial NCT01861041: Low Dose Bupivacaine Spinal for Trans Uretral Prostatectomy.
Official title: Low Dose, Low Concentration Different Baricity Bupivacaine for Transuretral Prostatectomy.
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: PHASE4
Conditions: Benign Prostate Hyperplasia
Keywords: low dose
different baricity
spinal anesthesia
Lead sponsor: Diskapi Yildirim Beyazit Education and Research Hospital
Sponsor class: OTHER_GOV
First posted: 2013-05-23
Enrollment: 52
Sex: MALE
Minimum age (years): 50
Maximum age (years): 85
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL

Brief summary: Spinal anesthesia, is used during the transuretheral resection of the prostate.Low dose hyperbaric local anesthetics have been used to enhance the resolution of the spinal block. We compared the efficacy and duration of the spinal block with two different bupivacaine baricities.

* Group I: low dose isobaric group
* GroupII: Low dose hyperbaric group

Detailed description: Patients undergoing TURP were randomly allocated into two groups.

* Group I: Received fentanyl 20 µgr (0.4ml),heavy bupivacaine 0.5% (1.5 ml)and normal saline % 0.9 NaCl ( 1.1ml)
* Group II: Received fentanyl 20 µgr (0.4 ml), plain bupivacaine 0.5%(1.5 ml) normal saline 0.9% NaCl (1.1 mL) in total bupivacaine 0.25% (3ml) intrathecally.

Onset and duration of the sensory block, the degree of the motor block, side - effects and perioperative analgesic requirement assesed.

Eligibility criteria: Inclusion Criteria:

* 50-85 years ASA 1-4 BENİGN PROSTAT HYPERPLASİ

Exclusion Criteria:

* Allergy of study drugs
* Morbid obesity
* Spinal anesthesia contrindications
* Bleeding dyscrasias

Primary outcomes:
measure: Spinal Block Quality
timeFrame: 15 minute after intrathecal injection
Secondary outcomes:
measure: Spinal block regression
timeFrame: 5 minute after arrival at PACU
Other outcomes:
Locations:
city: Ankara
country: Turkey
facility: Diskapi Yildirim Beyazit Education and Research Hospital
Study officials:
affiliation: Dispapi yildirim beyazit E R hospital
name: MURAT M SAYIN, Ass. Prof
role: STUDY_DIRECTOR
References:
citation: Loubert C, Hallworth S, Fernando R, Columb M, Patel N, Sarang K, Sodhi V. Does the baricity of bupivacaine influence intrathecal spread in the prolonged sitting position before elective cesarean delivery? A prospective randomized controlled study. Anesth Analg. 2011 Oct;113(4):811-7. doi: 10.1213/ANE.0b013e3182288bf2. Epub 2011 Sep 2.
citation: Kim SY, Cho JE, Hong JY, Koo BN, Kim JM, Kil HK. Comparison of intrathecal fentanyl and sufentanil in low-dose dilute bupivacaine spinal anaesthesia for transurethral prostatectomy. Br J Anaesth. 2009 Nov;103(5):750-4. doi: 10.1093/bja/aep263. Epub 2009 Sep 28.
Clinical trial NCT01278641: Men With Fibromyalgia or Chronic Widespread Pain - Effect of Exercise on Symptoms and Body Functions
Official title: Men With Fibromyalgia or Chronic Widespread Pain - Effect of Exercise on Symptoms and Body Functions
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Fibromyalgia
Pain
Keywords: Fibromyalgia
Widespread pain
Fatigue
Physical exercise
Lead sponsor: Göteborg University
Sponsor class: OTHER
First posted: 2011-01-19
Enrollment: 44
Sex: MALE
Minimum age (years): 18
Maximum age (years): 60
Standard ages: ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: A controlled randomised trial (CRT). 60 men who fulfil the ACR-criteria for Fibromyalgia or Chronic Widespread Pain (Wolfe 1990) participate in the study.

The main objective of the study is to compare the effect of a graded strength training program and a low intensive pool exercise program.

Detailed description: A controlled randomised trial (CRT). 60 men who fulfil the ACR-criteria for Fibromyalgia or Chronic Widespread Pain (Wolfe 1990) participate in the study.

40 patients (in the city Uddevalla) are randomised into two groups; low intensive temperate pool exercise program, and graded strength training program. The study period is 12 weeks.

20 patients (in the city Alingsås) make a reference group who is asked to continue their normal activities during the study period.

Primary outcomes are fatigue (using the Multidimensional fatigue inventory and VAS for global fatigue)and muscle strength (using Steve Strong, Isobex and the Grippit). Several other self-administered instruments was used.

Eligibility criteria: Inclusion Criteria:

Male patients with Fibromyalgia or Chronic Widespread pain

Exclusion Criteria:

Other severe physical or psychiatric disorders.

Primary outcomes:
measure: The multidimensional Fatigue Inventory (MFI-20)
timeFrame: 12 weeks
Secondary outcomes:
measure: The Hospital Anxiety and Depression Scale (HADS)
timeFrame: 12 weeks
measure: Muscle strength (measured with Isobex and Steve Strong)
timeFrame: 12 weeks
Other outcomes:
Locations:
city: Uddevalla
country: Sweden
facility: Sjukgymnastik Primärvård Rosenhäll
Study officials:
affiliation: Göteborg University, Dept of Rheumatology
name: Kaisa E Mannerkorpi, Ass Prof
role: PRINCIPAL_INVESTIGATOR
References:
citation: Ericsson A, Bremell T, Cider A, Mannerkorpi K. Effects of exercise on fatigue and physical capacity in men with chronic widespread pain - a pilot study. BMC Sports Sci Med Rehabil. 2016 Sep 6;8(1):29. doi: 10.1186/s13102-016-0054-9. eCollection 2016.
Clinical trial NCT01785641: Single Versus Combined Antibiotic Therapy for Bacterial Peritonitis in CAPD Patients
Official title: Single Versus Combined Antibiotic Therapy for Bacterial Peritonitis in Continuous Ambulatory Peritoneal Dialysis Patients
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Peritonitis
Keywords: peritoneal dialysis
peritonitis
Lead sponsor: Chulalongkorn University
Sponsor class: OTHER
First posted: 2013-02-07
Enrollment: 300
Sex: ALL
Minimum age (years): 15
Maximum age (years): 75
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: To compare the efficacy of single versus combined antibiotic therapy for bacterial peritonitis in CAPD patients.

Detailed description: To compare relapse and recurrent rate of peritonitis between single and combined antibiotic regimens for bacterial peritonitis in CAPD patients.

Eligibility criteria: Inclusion Criteria:

* age \>/= 18 years old
* ESRD patients on continuous ambulatory peritoneal dialysis more than 4 weeks
* presence of symptom or sign of peritonitis
* presence of WBC \>100cell/mm3 with PMN \>50% in peritoneal dialysate or gram stain positive for gram positive or gram negative bacteria

Exclusion Criteria:

* presence of polymicrobial organism, non-fermentative gram negative organism, fungus, mycobacteria in peritoneal fluid or culture-negative
* peritonitis from the organisms that required combined antibiotic therapy according to ISPD guideline 2010
* hospital-acquired peritonitis
* presence of catheter-related infection
* history of peritonitis within 4 weeks
* currently taking antibiotic
* allergic to the antibiotic that used in the study(penicillin or cephalosporin or quinolone or aminoglycoside)

Primary outcomes:
measure: relapse or recurrent rate
timeFrame: within 4 weeks after peritonitis treatment
Secondary outcomes:
Other outcomes:
Locations:
city: Bangkok
country: Thailand
facility: Chulalongkorn university
Study officials:
affiliation: Chulalongkorn University
name: Nalinee Saiprasertkit, MD.
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT06534619: Additional Effects of Joint Mobilization in Addition to Rocabado Exercises on Alleviating Trismus Following Third Molar Extraction
Official title: Additional Effects of Joint Mobilization in Addition to Rocabado Exercises on Alleviating Trismus Following Third Molar Extraction
Study type: INTERVENTIONAL
Overall status: ACTIVE_NOT_RECRUITING
Phase: NA
Conditions: Trismus
Lead sponsor: Foundation University Islamabad
Sponsor class: OTHER
First posted: 2024-08-02
Enrollment: 54
Sex: ALL
Minimum age (years): 18
Maximum age (years): 45
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Intervention model description: This is a randomized controlled trail, having two groups. One group will receive Maitland joint mobilization along with rocabado exercises and the second will receive rocabado exercises only. Both groups will be recruited concurrently.
Primary purpose: TREATMENT

Brief summary: Without appropriate early intervention, prolonged trismus can lead to lasting complications like reduced jaw mobility or temporomandibular joint disorders.Therefore joint mobilization will impact on trismus, that will offer valuable insights into how these interventions will affect inflammation, muscle function and overall healing process within TMJ besides rocabado exercises that involves a series of movements and stretches targeting the muscles and joints involved in chewing,swallowing and speaking and minimizing muscle tension and opening the mouth, preventing further deterioration of jaw function and improving overall quality of life of individuals. If found effective, this will be added to the literature for the treatment of trismus after third molar extraction.


Eligibility criteria: Inclusion Criteria:

* Referral or consultation from a dentist to confirm the diagnosis of trismus.
* Age 18-45 years
* Both genders (Male and Female)
* Maximal interincisal opening ≤ 35mm (Restricted jaw motion).
* Unilateral/Bilateral impacted lower third molars.
* 3 days Post mandibular Third molar extraction

Exclusion Criteria:

* Local Infection or bleeding post third molar extraction.
* Patients with Acute pericoronitis
* Patient undergoing chemotherapy and radiotherapy.
* Type I diabetes, renal failure and chronic liver disease were excluded as immunocompromised state.
* Pregnant or lactating women.
* Cyst or tumor associated with impacted tooth

Primary outcomes:
measure: Pain intensity
timeFrame: 1 week
measure: Range of motion
timeFrame: 1 week
measure: Functional Performance
timeFrame: 1 week
Secondary outcomes:
Other outcomes:
Locations:
city: Rawalpindi
country: Pakistan
facility: Foundation University College of Physical Therapy
state: Punjab
Study officials:
References:
Clinical trial NCT04390919: Prognostic Factors of Patients With ADHF
Official title: Elevated Blood Monocyte Count Predicts 1 Year Poor Outcomes for Patients Admitted With Acute Decompensated Heart Failure
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Acute Decompensated Heart Failure
Keywords: monocyte count
heart failure
acute decompensated heart failure
all-cause death
Lead sponsor: Chongqing Medical University
Sponsor class: OTHER
First posted: 2020-05-18
Enrollment: 362
Sex: ALL
Minimum age (years): 18
Maximum age (years): 94
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: RETROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: ADHF patient diagnosed in the department of cardiovascular medicine in the first affiliated hospital of chongqing medical university

Brief summary: To explore the prognostic indicators for patients with ADHF

Detailed description: According to ESC Guidelines for the diagnosis of acute heart failure 2008, patients with ADHF were diagnosed, and their medical history, laboratory examination and treatment plan were retrospectively analyzed, and the patients were followed up for 1 year. The 1-year outcomes of patients were analyzed to explore the prognostic indicators for patients with ADHF

Eligibility criteria: Inclusion Criteria:

* Patients with ADHF diagnosed according to ESC Guidelines for the diagnosis of acute heart failure 2008

Exclusion Criteria:

* disorders of the hematopoietic system, history of cancer and/or previous treatment with chemotherapy, the infection caused by various pathogens, chronic inflammatory conditions, glucocorticoid therapy and/or histories of glucocorticoid use 3 months before the admission and acute myocardial infarction or coronary revascularization within the past 6 months. Also, patients who did not have a differential WBC count or who were lost to follow-up were excluded.

Primary outcomes:
measure: all-cause death
timeFrame: 1 year
Secondary outcomes:
measure: HF-related rehospitalization
timeFrame: 1 year
Other outcomes:
Locations:
Study officials:
References:
Clinical trial NCT04874519: Registry to Collect Health Information Related to Fibrolamellar Cancer
Official title: Fibrolamellar Carcinoma Global Dynamic Registry
Study type: OBSERVATIONAL
Overall status: ACTIVE_NOT_RECRUITING
Conditions: Fibrolamellar Cancer
FLC
Liver Cancer
Keywords: fibrolamellar cancer
liver cancer
20-543
Memorial Sloan Kettering Cancer
Lead sponsor: Memorial Sloan Kettering Cancer Center
Sponsor class: OTHER
First posted: 2021-05-05
Enrollment: 100
Sex: ALL
Minimum age (years): 13
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Potential research subjects may also be identified by a member of the patient's treatment team, the protocol investigator, or research team at Memorial Sloan Kettering Cancer Center (MSKCC). If the investigator is a member of the treatment team, s/he will screen their patient's medical records for suitable research study participants and discuss the study and their potential for enrolling in the research study. Potential subjects contacted by their treating physician will be referred to the investigator/research staff of the study.

Brief summary: The purpose of this study is to collect information about people with fibrolamellar cancer (FLC). This study is a registry of people with FLC around the world. This study will involve collecting information about participants, their medical history and the regular medical care they receive for FLC. The study will not provide treatment for your cancer.


Eligibility criteria: Inclusion Criteria:

* Age 13 years or older.
* Personal history of histologically proven fibrolamellar carcinoma (clinical or radiographical suspicion of FLC must be confirmed at MSK or an external hospital)
* Participants must have access to electronic devices that meet the following minimum requirements:

  * Ability to connect to the internet
  * Capability of running modern internet browers (such as Google Chrome, Internet Explorer, Safari, or Mozilla Firefox).
* Participants must have a google account

Exclusion Criteria:

* Participants residing in the European Union (EU).

Primary outcomes:
measure: Build a Fibrolamellar Cancer/FLC registry
timeFrame: 18 months
Secondary outcomes:
Other outcomes:
Locations:
city: New York
country: United States
facility: Memorial Sloan Kettering Cancer Center (All Protocol Activities)
state: New York
Study officials:
affiliation: Memorial Sloan Kettering Cancer Center
name: Ghassan Abou-Alfa, MD, MBA
role: PRINCIPAL_INVESTIGATOR
References: