Clinical trial NCT06905236: Kidney Function in Obese Women
Official title: Kidney Function Markers in Postmenopausal Obese Women: Response to Aerobic Training
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Kidney Function Tests
Keywords: Glomerular Filtration Rate
neutrophils
obesity
serum creatinine
walking training
white blood cells
Lead sponsor: High Institute of Sports and Physical Education of Kef
Sponsor class: OTHER
First posted: 2025-04-01
Enrollment: 36
Sex: FEMALE
Minimum age (years): 50
Maximum age (years): 60
Standard ages: ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: PREVENTION

Brief summary: The goal of this clinical trial is to investigate the impact of a 10-week moderate intensity interval walking training (MIIWT) program on kidney function markers in obese postmenopausal women. The main question it aims to answer is:

Does MIIWT improve kidney function markers in this population? Researchers will compare MIIWT (designed to training group) to non-training intervention (designed to control group) to see if the training program works to improve kidney function markers.

Participants in training group will: perform a 10-week MIIWT program, four sessions per week (5 repetitions of 6-min-walking-test (6MWT) at 60-80% of 6MWTdistance measured at baseline, interspersed by 6-min of active recovery between repetitions). Participants in control group will : not perform any physical training and maintain their usual daily activities.

Detailed description: The convergence of the obesity pandemic and the postmenopausal status is likely associated with renal function decline. Regular aerobic training have been shown to prevent adverse health outcomes in obese. The main purpose of this study was to evaluate changes in kidney function markers and white blood cell (WBC) subpopulations in obese postmenopausal women participating in moderate intensity interval walking training (MIIWT). A total of 36 obese postmenopausal women were randomized to MIIWT (CON, n=18) or control group (CON, n=18), four times a week for 10-week. The MIIWT consisted on 5 repetitions of walking for 6-min at 60-80% of the 6-min-walk-test-distance with 6-min of active recovery between repetitions. Before and after the MIIWT, body composition, kidney function markers (serum creatinine \[sCr\], blood urea nitrogen \[BUN\], serum uric acid \[sUA\] and Glomerular Filtration Rate \[GFR\] and white blood cells (WBC) count and its specific subpopulations (neutrophils \[NEU\], lymphocytes \[LYM\], monocytes \[MON\], eosinophils \[EOSI\] and basophils \[BASO\]) were assessed.

Eligibility criteria: Inclusion Criteria:

* be aged between 50 and 60 years.
* be postmenopausal (absence of menses \> 12 months).
* present a BMI greater than or equal to 30 kg/m2.
* be free of any special diets in the three months prior to the start of the intervention.
* have a sedentary lifestyle (exercise less than 2 h/week).

Exclusion Criteria:

* Suffering from any cardiovascular/renal/pulmonary/metabolic disease.
* Being under menopausal hormone therapy.
* Presenting any orthopedic limitations interfering the ability to perform the study intervention.

Primary outcomes:
measure: serum creatinine
timeFrame: At baseline and at week 11(after the ten weeks of the training intervention).
measure: blood urea nitrogen
timeFrame: At baseline and at week 11(after the ten weeks of the training intervention).
measure: serum uric acid
timeFrame: At baseline and at week 11(after the ten weeks of the training intervention).
measure: glomerular Filtration Rate
timeFrame: At baseline and at week 11(after the ten weeks of the training intervention).
measure: white blood cells count
timeFrame: At baseline and at week 11(after the ten weeks of the training intervention).
measure: neutrophils
timeFrame: At baseline and at week 11(after the ten weeks of the training intervention).
measure: lymphocytes
timeFrame: At baseline and at week 11(after the ten weeks of the training intervention).
measure: monocytes
timeFrame: At baseline and at week 11(after the ten weeks of the training intervention).
measure: eosinophils
timeFrame: At baseline and at week 11(after the ten weeks of the training intervention).
measure: basophils
timeFrame: At baseline and at week 11(after the ten weeks of the training intervention).
Secondary outcomes:
measure: Body composition
timeFrame: At baseline and after ten weeks of the training intervention.
measure: 6 min walking test
timeFrame: At baseline and after ten weeks of the training intervention.
Other outcomes:
Locations:
city: Boulifa
country: Tunisia
facility: High Institute of Sports and Physical Education of Kef
state: Kef
Study officials:
References: