Clinical trial NCT02179437: Intraoperative TIVA With Propofol on Postoperative Pain and Side Effects After Liver Resection Surgery
Official title: Retrospective Study to Investigate Intraoperative TIVA With Propofol on Postoperative Pain and Side Effects After Liver Resection Surgery
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Postoperative Pain
Keywords: TIVA
Propofol
Postoperative pain
Liver resection surgery
Retrospective study
Lead sponsor: The University of Hong Kong
Sponsor class: OTHER
First posted: 2014-07-01
Enrollment: 95
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: OTHER
Time perspective: RETROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: Patient undergone liver resection surgery between 2010 to 2012 in Queen Mary Hospital

Brief summary: Postoperative pain can be severe after liver resection surgery. However, postoperative pain management may be difficult for this group of patients. Opioidergic neurotransmission may be altered in cirrhotic patients and selectively increasing receptor affinity for opioids. Large dose of strong opioid may be required to achieve adequate pain control. However, this may not be possible due to the side effect of opioid and liver dysfunction after liver resection.

Propofol is a commonly used anaesthetic with rapid recovery and less side effects and TIVA (total intravenous analgesia) with propofol is a common technique now. The reduction on certain serum pro- inflammatory cytokines may lead to more smooth post- surgical recovery.

Recent case report proved the analgesic effect of propofol infusion. However other animal and clinical studies showed controversial result.

The aim of this retrospective study is to investigate the postoperative analgesic effects and side effects of intraoperative TIVA with propofol in patient undergoing liver resection surgery at Queen Mary Hospital, Hong Kong between 2010 to 2012.

Detailed description: Retrospective audit.

Anaesthetic records and acute pain service records of patient undergone liver resection surgery between 2010 to 2012 in Queen Mary Hospital would be retrieved from the computer.

Data Collection

1. Demographic data;
2. Types of analgesic techniques;
3. Type of pain relief modalities;
4. Pain score up to 72 hours postoperatively;
5. Postoperative opioid consumption;
6. Incidence of adverse events during APS care;
7. Patients' satisfaction on pain relief.

Data Analysis For summarising analysis, mean or median with standard deviation or interquartile range will be reported. Parametric and non-parametric comparative tests will be used for analysis between/among patients with various characteristics. Kaplan Meier survival analysis and log-rank test will be used for duration of APS use.

Eligibility criteria: Inclusion Criteria:

* Patient undergone liver resection surgery between 2010 to 2012 in Queen Mary Hospital

Exclusion Criteria:

* Essential data were missing.
* Patient participating in other research projects.
* Changes in postoperative pain management technique.
* Patients could not be assessed post-operatively for pain (i.e. post-operative IPPV)

Primary outcomes:
measure: Postoperative pain score
timeFrame: From postoperative 1 hour to postoperative 72 hour
Secondary outcomes:
measure: Adverse event
timeFrame: From postoperative 1 hour to postoperative 72 hour
Other outcomes:
measure: Analgesic consumption
timeFrame: From postoperative 1 hour to postoperative 72 hour
Locations:
city: Hong Kong
country: China
facility: Department of Anaesthesiology, The University of Hong Kong
state: Hong Kong
Study officials:
affiliation: Department of Anaesthesiology, The University of Hong Kong
name: Chi Wai Cheung, MD
role: PRINCIPAL_INVESTIGATOR
References:
citation: Chan AC, Qiu Q, Choi SW, Wong SS, Chan AC, Irwin MG, Cheung CW. Effects of Intra-Operative Total Intravenous Anaesthesia with Propofol versus Inhalational Anaesthesia with Sevoflurane on Post-Operative Pain in Liver Surgery: A Retrospective Case-Control Study. PLoS One. 2016 Feb 22;11(2):e0149753. doi: 10.1371/journal.pone.0149753. eCollection 2016.