louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT05311800: High-Intensity Interval Training and Fat Mass Losses
Official title: Effect of Two Isoenergetic Modes of High-Intensity Interval Training on Total and Abdominal Fat Mass Loss in Men With Overweight or Obesity.
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Overweight and Obesity
Men
Keywords: cycling
running
high-intensity interval training
fat mass
visceral tissue
health
Lead sponsor: Laboratoire des Adaptations Métaboliques à l'Exercice en conditions Physiologiques et Pathologiques
Sponsor class: OTHER
First posted: 2022-04-05
Enrollment: 9
Sex: MALE
Minimum age (years): 18
Maximum age (years): 65
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Intervention model description: 2 groups : running vs cycling
Primary purpose: TREATMENT

Brief summary: The aims of this study was to compare two isoenergetic HIIT (High-intensity Interval training) programs (cycling vs. running) on body composition, substrate oxidation at rest and during a moderate exercise, muscle functionality, glycaemic control, lipid profile, inflammation, maximal aerobic capacity (VO2max) and gut microbiota composition in men with overweight or obesity.

The investigators hypothesized that both programs could decrease total, abdominal and visceral fat mass but due to differences in muscle solicitation, metabolism adaptation and blood flow, and that running could favors greater fat mass losses.

Detailed description: The first aim of this study was to compare two isoenergetic HIIT programs (cycling vs. running) on body composition in men with overweight or obesity.

20 men with overweight or obesity should completed HIIT program three times a week during twelve weeks.

i) High intensity interval training - BIKE (HIIE BIKE) 10 cycles of speeding up for 45 s at 80-thPHR followed by pedaling slowly (40% thPHR) for 1m30s (37min30s) ii) High intensity interval training - RUN (HIIE RUN) 9 cycles of speeding up for 45 s at 80-thPHR followed by pedaling slowly (40% thPHR) for 1m30s (35min15s)

Body composition will be measured before and after HIIT program by Dual-energy X-ray absorptiometry (DXA).

Eligibility criteria: Inclusion Criteria:

* men (18 to 65 years old)
* with overweight or obesity (BMI \> 25 kg/m2 and ≤ 40 kg/m2)

Exclusion Criteria:

* medical contraindications to intense physical activity,
* painful joints,
* taking ß-blocker

Primary outcomes:
measure: HIIT mode and fat mass change (g)
timeFrame: At the first and the last training - week 1 and 12
measure: HIIT mode and abdominal fat mass change (g)
timeFrame: At the first and the last training - week 1 and 12
Secondary outcomes:
measure: Rate of carbohydrate and lipid oxidation (g.min-1) during a sub-maximal exercise by measuring gaz exchange.
timeFrame: At the first and the last training - week 1 and 12
Other outcomes:
Locations:
city: Bellerive-sur-Allier
country: France
facility: CREPS Auvergne Rhône-Alpes / Vichy
state: Allier
Study officials:
References:
Clinical trial NCT06285500: Umbrella Study for Single Patient Treatments in Oncology
Official title: UNIQUE: Umbrella N-of-1 Tumor Trials - Umbrella Protocol for Oncology Single Patient Protocols
Study type: OBSERVATIONAL
Overall status: RECRUITING
Conditions: Advanced Cancer
Rare Diseases
Lead sponsor: University Health Network, Toronto
Sponsor class: OTHER
First posted: 2024-02-29
Enrollment: 400
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: OTHER
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Patients have advanced and rare cancer with limited treatment options.

Brief summary: The purpose of this study is to collect data on how advanced and rare cancers respond to biomarker-based treatments.

Detailed description: The UNIQUE umbrella protocol is an overarching framework to study precision medicine in patients with precise molecular data, who have exhausted all established treatment options and who are not eligible for any of the ongoing trials. There is no additional visit or procedure required to participate in this study. Participants who have received/who may receive the following treatments may join the study and will be assigned to a study cohort (group):

* Group 1 - Health Canada approved/marketed drug(s) used on or off-label as Standard of Care (SOC)
* Group 2 - Drugs accessed from Special Access Program (SAP)
* Group 3 - Non-marketed investigational agents

Under the UNIQUE framework, data from participants will be evaluated. The following data will be collected:

* Demographic data (for example: sex, race, month and year of birth)
* Medical history
* Cancer characteristics including biomarkers
* Treatment history
* response to treatment

Eligibility criteria: Inclusion Criteria \& Exclusion Criteria:

Patient's existing genomic information from tumor molecular profiling will be discussed in the hospital expert molecular tumor board rounds consisting of representatives from specialist genomic profiling and medical oncology departments to decide N of 1 treatment for the patient. The discussion will surround the best next therapeutic option in the patient's cancer subtype with or without clear standard of care guidelines. Therefore, specific eligibility criteria aside from individual patient's medical history is not applicable.

Primary outcomes:
measure: Overall response rate for the overall cohorts and the number of patients accessing precision targeted therapy
timeFrame: 3 years
Secondary outcomes:
measure: Overall survival rate
timeFrame: 5 years
measure: Progression-free survival rate
timeFrame: 5 years
measure: Number of participants with adverse events as assessed by CTCAE v5.0
timeFrame: 5 years
Other outcomes:
Locations:
city: Toronto
country: Canada
facility: University Health Network, Princess Margaret Cancer Centre
state: Ontario
Study officials:
affiliation: University Health Network, Toronto
name: Amit Oza, Dr.
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT04837300: Resisted Sprint and Plyometric Training on Lower Limb Functional Performance in Young Adult Male Football Players.
Official title: Effect of Resisted Sprint and Plyometric Training on Lower Limb Functional Performance in Young Adult Male Football Players. A Randomized Control Trial
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Football Players
Keywords: Strength
Plyometric training
Function performance
Resisted sprint training
Lead sponsor: Majmaah University
Sponsor class: OTHER
First posted: 2021-04-08
Enrollment: 90
Sex: MALE
Minimum age (years): 18
Maximum age (years): 25
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Intervention model description: Randomized controlled trial
Primary purpose: BASIC_SCIENCE

Brief summary: This study aims to evaluate the short-term effects of resisted sprint training on sprint performance together with lower limb physiological and functional performance in young professional football players.

Detailed description: Ninety collegiate football players were recruited, with a mean age of 20.48 at the university campus. All of which were randomly divided into two experimental groups RST(n=30), PLT (n=30) participated in training for six weeks on alternate days (i.e., three sessions per week) and one control group (n=30) did not train. The control group was instructed to maintain regular activities and avoid any strenuous physical activity during the study. No significant between-group baseline or pre-to-post-training differences in anthropometrics were observed.

Under the Declaration of Helsinki, participants were informed about the study's possible risks and benefits, and all participants have signed informed consent before participation in the study. Ethical sub-committee of College of applied medical science, Majmaah, Saudi Arabia approved this study (Ethics Number: MUREC-Dec.15/COM-2020 / 13-2).

Eligibility criteria: Inclusion Criteria:

* Young players aged between 18 and 25 years required frequent sprinting

Exclusion Criteria:

* Current injury to lower limb.
* Surgery affecting lower limb function.
* Any cardio-respiratory diseases.
* Impairments of spine or lower extremities.

Primary outcomes:
measure: Knee Extensors Strength Test.
timeFrame: After 6 weeks of intervention.
measure: Sprint Test.
timeFrame: After 6 weeks of intervention.
measure: Single-Leg Triple Hop Test.
timeFrame: After 6 weeks of intervention.
Secondary outcomes:
Other outcomes:
Locations:
city: Riyadh
country: Saudi Arabia
facility: Football Playground
Study officials:
affiliation: Majmaah University
name: Shahnaz Hasan, PhD
role: PRINCIPAL_INVESTIGATOR
References:
citation: Hasan S, Kandasamy G, Alyahya D, Alonazi A, Jamal A, Unnikrishnan R, Muthusamy H, Iqbal A. Effect of Resisted Sprint and Plyometric Training on Lower Limb Functional Performance in Collegiate Male Football Players: A Randomised Control Trial. Int J Environ Res Public Health. 2021 Jun 22;18(13):6702. doi: 10.3390/ijerph18136702.
Clinical trial NCT06810700: The Association Between Time in Range With Markers of Endothelial and Cardiovascular Function
Official title: The Association Between Time in Range With Markers of Endothelail an Dcardiovascular Function in Patients With type1 Diabetes Mellitus and Minimed 780G
Study type: OBSERVATIONAL
Overall status: NOT_YET_RECRUITING
Conditions: Type 1 Diabetes
Lead sponsor: Attikon Hospital
Sponsor class: OTHER
First posted: 2025-02-05
Enrollment: 90
Sex: ALL
Minimum age (years): 12
Maximum age (years): 80
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: CROSS_SECTIONAL
Sampling method: NON_PROBABILITY_SAMPLE
Study population: patients aged \>12 years old with T1DM who are on MiniMed 780G system .

Brief summary: In this observaltional study, 90 patients aged \>12 years old with T1DM who are on MiniMed 780G system will be included.We aim to investigate the association between time in range (70-140mg/dl) and time in tight range (70-180mg/dl) with markers of endothelial and cardiovascular function.

Detailed description: In this observational study, 90 participants with T1D on MiniMed 780G system will be included. HbA1c, anthropometric measurements, CGM and Insulin Metrics will be assessed in all patients. Moreover, the investigators will assess:

1. the pulse wave velocity, the augmentation index and the central systolic blood pressure which are markers of arterial stiffness
2. the perfused boundary region of subglingulal vessels which is marker of endothelial function
3. the global longitudinal strain which is marker of myocardial function.

Eligibility criteria: Inclusion Criteria:

1. Clinical diagnosis of type 1 diabetes \>1 year prior to consent date. Diagnosis of type 1 diabetes is based on the investigator's judgment; C peptide level and antibody determinations are not required.
2. HbA1c \< 12.5%
3. Age \>7years at the initiation of the system
4. Multiple Daily Injections (Basal Bolus therapy) with Total daily insulin use of great than 8.0 units per day over a 1-week period
5. Clinically able to start the AHCL system
6. History of 3 clinic visits in the last year

Exclusion Criteria:

1. Diabetic Ketoacidosis in the 6 months prior to screening visits

Primary outcomes:
measure: Endothelial glycocalyx
timeFrame: Baseline
measure: Pulse wave velocity
timeFrame: Baseline
measure: Global longitudinal strain
timeFrame: Baseline
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
References:
Clinical trial NCT05488600: Executive Functions in Elite Athletes
Official title: Comparison of the Executive Functions of Elite Team-Sport and Individual-Sport Athletes
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Cognitive Change
Keywords: Elite Athletes
Executive Function
Cognition
Sports
Team Sports
Lead sponsor: Istanbul Medipol University Hospital
Sponsor class: OTHER
First posted: 2022-08-04
Enrollment: 90
Sex: ALL
Minimum age (years): 20
Maximum age (years): 30
Standard ages: ADULT
Accepts healthy volunteers: yes
Observational model: CASE_CONTROL
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Elite athletes participating in national and international competitions in Turkish Basketball Federation, Turkish Volleyball Federation and Turkish Football Federation clubs and Gaziantep Youth Sports Center

Brief summary: In the study, it was aimed to compare the executive functions of elite athletes who do team sports and individual sports with each other and with individuals who do not do sports.

Detailed description: In the study, it was aimed to compare the executive functions of elite athletes who do team sports and individual sports with each other and with individuals who do not do sports. 60 elite athletes participating in national and international competitions between the ages of 20-30, affiliated to the Republic of Turkey Ministry of Youth and Sports and federations, and 30 individuals who did not do sports for the control group were included in the study group. Of the elite athletes, 30 were included in the team sports group and 30 in the individual sports group. Executive functions Forward and Backward Digit Span Test, Stroop Test, Trail Making Test A and B form (TMT-A, TMT-B) and Tower of London (ToL) Test evaluated with.

Eligibility criteria: Inclusion Criteria:

* Be between 20-30 years old
* Have been doing sports for at least 5 years
* Being an elite athlete
* Being actively involved in sports

Exclusion Criteria:

* Having any psychological or neurological disease

Primary outcomes:
measure: London Tower Test
timeFrame: day 1
Secondary outcomes:
measure: Digit Span Test
timeFrame: day 1
measure: Stroop Test
timeFrame: day 1
measure: Trail Making Test
timeFrame: day 1
Other outcomes:
Locations:
city: Beykoz
country: Turkey
facility: Istanbul Medipol University
state: Istanbul
Study officials:
References:
citation: Meng FW, Yao ZF, Chang EC, Chen YL. Team sport expertise shows superior stimulus-driven visual attention and motor inhibition. PLoS One. 2019 May 15;14(5):e0217056. doi: 10.1371/journal.pone.0217056. eCollection 2019.
citation: De Waelle S, Laureys F, Lenoir M, Bennett SJ, Deconinck FJA. Children Involved in Team Sports Show Superior Executive Function Compared to Their Peers Involved in Self-Paced Sports. Children (Basel). 2021 Mar 30;8(4):264. doi: 10.3390/children8040264.
Clinical trial NCT02306200: Cardiovascular Health Improvement Project
Official title: Cardiovascular Health Improvement Project
Study type: OBSERVATIONAL
Overall status: RECRUITING
Conditions: Aortic Aneurysm
Aortic Dissection
Bicuspid Aortic Valve (BAV)
Heart Failure
Cardiovascular Diseases
Keywords: Aorta
Abdominal Aortic Aneurysm (AAA)
Thoracic Aortic Aneurysm (TAA)
Bicuspid Aortic Valve (BAV)
Aortic Dissection
Lead sponsor: University of Michigan
Sponsor class: OTHER
First posted: 2014-12-03
Enrollment: 9999
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: CASE_CONTROL
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Outpatient clinic

Brief summary: The goal of this project is to establish a biobank of clinical information, DNA, plasma, and aortic tissue samples from patients with cardiovascular disease as well as healthy controls.

Detailed description: The goal of this project is to establish a biobank of clinical information, DNA, plasma, and aortic tissue samples from patients with cardiovascular disease as well as healthy controls. The aims of the study are to collect biological specimens (blood, plasma, serum, aortic tissue) and family history; establish a biobank, establish a comprehensive database with information from consented patients, and provide researchers with high quality well annotated DNA samples with demographic and clinical information.

Eligibility criteria: Inclusion Criteria:

* Any patient over the age of 18 who is able/willing to give informed consent
* Patients \<18 years of age with parental consent and assent (if assent is applicable for their age)
* Diagnosis of:
* aortic pathology potentially due to a known or suspected inherited condition
* Idiopathic aortic aneurysm
* Interesting of novel vascular pathology in the aorta or main branches
* Family history of aortic or vascular disease
* Other cardiovascular disease
* Healthy controls with no apparent cardiovascular disease

Exclusion Criteria:

- Not willing or able to sign the consent

Primary outcomes:
measure: Establishing a biobank of patients with Aortic Disease
timeFrame: 40 years
Secondary outcomes:
Other outcomes:
Locations:
city: Ann Arbor
country: United States
facility: University of Michigan
state: Michigan
Study officials:
affiliation: University of Michigan
name: Marion A Hofmann Bowman, PhD, MD
role: PRINCIPAL_INVESTIGATOR
References:
citation: Love-Nichols J, Uhlmann WR, Arscott P, Willer C, Hornsby W, Roberts JS. A survey of aortic disease biorepository participants' preferences for return of research genetic results. J Genet Couns. 2021 Jun;30(3):645-655. doi: 10.1002/jgc4.1341. Epub 2020 Dec 14.
Clinical trial NCT05088200: A Retrospective Case Series Study for Acute Abdomen in General Surgery Ward
Official title: A Retrospective Case Series Study for Acute Abdomen in General Surgery Ward
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: The Study Was Aimed to Assessing the Clinical Profile of Acute Abdomen and Their Frequency According to Age and Sex
Keywords: Acute abdomen, Abdominal pain, Acute appendecitis, intestinal obstruction
Lead sponsor: Kabul University of Medical Sciences
Sponsor class: OTHER
First posted: 2021-10-21
Enrollment: 118
Sex: ALL
Minimum age (years): 15
Maximum age (years): 94
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: OTHER
Time perspective: RETROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: All of patients with acute abdomen that is admitted in general surgery ward of Aliabad.

Brief summary: The acute abdomen is a clinical situation in which an acute an change in the condition of intra-abdominal organ, commonly attached to inflammation or infection need urgent and correct diagnosis .

Detailed description: A special data collection sheet designed to collect data regarding the diagnosis, age and sex from the profile of patients retrospectively. Data entry was performed by using Microsoft Excel and all the data were analysed by SPSS.

Eligibility criteria: Inclusion Criteria:

* All of patients with acute abdomen that is admitted in general surgery ward of Aliabad teaching hospital.

Exclusion Criteria:

* traumatic abdominal injury, abdominal pain due to urological and gynaecological origin.

Primary outcomes:
measure: A retrospective case series study for acute abdomen in general surgery ward of Aliabad teaching hospital
timeFrame: 21 March 2018-21 March 2019
Secondary outcomes:
Other outcomes:
Locations:
city: Kabul
country: Afghanistan
facility: Ahmadullah Danish
Study officials:
References:
Clinical trial NCT03182400: Neurophysiological Study of Sensory and Cognitive Processes in Healthy Children and Adults
Official title: Neurophysiological Study of Sensory and Cognitive Processes in Healthy Children and Adults
Study type: INTERVENTIONAL
Overall status: RECRUITING
Phase: NA
Conditions: Healthy Volunteer
Lead sponsor: University Hospital, Tours
Sponsor class: OTHER
First posted: 2017-06-09
Enrollment: 450
Sex: ALL
Minimum age (years): 1
Maximum age (years): 60
Standard ages: CHILD
ADULT
Accepts healthy volunteers: yes
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: BASIC_SCIENCE

Brief summary: It is now widely accepted that autism is linked to a developmental disorder and cerebral function.

Our research team (UMR U930 INSERM, François-Rabelais University of Tours, whom Pr F Bonnet-Brilhault is responsible for team "Autism") hypothesizes that atypical sensory information processing, especially auditory and / or visual information, could underly the symptoms observed in autism. A better knowledge of the typical development of the sensory and cognitive processes must therefore make it possible in the long term to identify the abnormalities linked to the autism spectrum disorders (ASD).

Studies in healthy subjects are therefore necessary in order to identify neurophysiological indices of cerebral functioning and to study their evolution during normal development, making it possible in the future to compare with populations of subjects with ASD.

The investigators intend to study the development of all the cognitive processes involved in the processing of sensory and, in particular, auditory and visual information in humans: from low-level perception processes to higher-level cognitive processes (attention, emotion, language, prediction, ...). For this the investigators will use non-invasive neurophysiological explorations (EEG, eye tracking) as well as neuropsychological explorations (Questionnaires or spontaneous language recording).

A better understanding of the pathophysiological mechanisms underlying the symptoms observed in autism could ultimately lead to the development of new specific therapeutic strategies, particularly in the field of exchange and development therapy or cognitive remediation .


Eligibility criteria: Inclusion Criteria:

* Between 1 and 60 years-old
* Able to understand and apply instructions for a task
* Information of subject or legal representant
* Informed written consent of subject or legal representant
* Affiliation to the social security system

Exclusion Criteria:

* Abnormal corrected vision
* Abnormal audition
* Known personal neurological pathology
* Known personal psychiatric problems
* Identified difficulties for walking, language, or learning
* Exclusion period because of participation to another experimental protocol
* Adult with legal protection

Primary outcomes:
measure: ERP amplitude (µV)
timeFrame: 1 hour
Secondary outcomes:
measure: Reaction times (ms)
timeFrame: 1 hour
measure: pupil size (mm)
timeFrame: 1 hour
Other outcomes:
Locations:
city: Tours
country: France
facility: Chru Tours
Study officials:
References: