Clinical trial NCT05714787: Opportunistic Screening for Osteoporotic Vertebral Fractures in Patients With Diffuse Interstitial Lung Disease
Official title: Opportunistic Screening for Vertebral Osteoporotic Fractures on Chest CT Scan Evaluation of Patients With Interstitial Lung Disease : COLIBRI Based Retrospective Study
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Osteoporosis
Interstitial Lung Disease
Vertebral Fracture
Lead sponsor: Centre Hospitalier Universitaire de Nice
Sponsor class: OTHER
First posted: 2023-02-06
Enrollment: 202
Sex: ALL
Minimum age (years): 18
Maximum age (years): 95
Standard ages: ADULT
OLDER_ADULT
Observational model: COHORT
Time perspective: RETROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Patients are from a cohort data base named COLIBRI which collected date about with intersititial lung disease, recruited in Pneumology Department in Centre hospitalier universitaire de Nice.

Brief summary: It is well known that some chronic respiratory pathologies such as asthma or chronic obstructive pulmonary disease (COPD) are associated with an increased risk of osteoporosis, due to the pathology itself and the therapies implemented (per-os or inhaled corticosteroids). Osteoporosis leads to an increased risk of fragility fracture, with an increased morbidity and mortality associated with severe fractures such as vertebral fractures. Also, osteoporotic vertebral fractures often occur at the thoracolumbar hinge, resulting in worsening of the thoracic kyphosis. However, to the best of our knowledge, the prevalence of osteoporotic vertebral fractures measured by CT scan in patients with interstitial lung disease (ILD) is not known. For these patients who already have impaired respiratory function, the appearance of vertebral fractures could impact their management and worsen their prognosis (additional restrictive syndrome, difficulties in analgesics management because of respiratory contraindications, difficulties in wearing a corset, etc...). In this context, it appears interesting to define the prevalence of osteoporosis and osteoporotic vertebral fractures at the thoracic spine and the thoraco-lumbar hinge in a population of patients followed for ILD. So, the main objective of this study is to describe the prevalence of vertebral osteoporotic fractures in an overall cohort of patients with ILD.


Eligibility criteria: Inclusion Criteria:

* Patients older than 18 years old ;
* Patients included in the COLIBRI database for ILD between January 2017 and January 2023 ;
* Patients with a chest CT scan performed at the Nice center university hospital.

Exclusion Criteria:

* Absence of a thoracic CT scan performed at Nice center university hospital
* Secondary vertebral fracture

Primary outcomes:
measure: Presence or absence of vertebral fracture in the global cohort
timeFrame: 6 years
Secondary outcomes:
measure: Presence or absence of vertebral fracture in subgroups
timeFrame: 6 years
measure: To compare bone mineral density in Hounsfield Unit of patients with or without at least one vertebral fracture.
timeFrame: 6 years
Other outcomes:
Locations:
city: Nice
country: France
facility: Chu de Nice
Study officials:
References: