Clinical trial NCT06936241: Effect of Circuit Weight Training on Functional Capacity and Quality of Life in Breast Cancer Patients
Official title: Effect of Circuit Weight Training on Functional Capacity and Quality of Life in Breast Cancer Patients
Study type: INTERVENTIONAL
Overall status: NOT_YET_RECRUITING
Phase: NA
Conditions: Breast Cancer
Lead sponsor: Cairo University
Sponsor class: OTHER
First posted: 2025-04-20
Enrollment: 52
Sex: ALL
Minimum age (years): 35
Maximum age (years): 45
Standard ages: ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The study is aimed at studying the effects of Circuit Weight Training (CWT) on functional capacity and quality of life in breast cancer patients.

Detailed description: Breast Cancer is the most common cancer among women in Egypt causing 22 percent of all cancer-related female deaths. It is the most commonly diagnosed cancer, accounting for nearly a quarter of all cancer cases globally.

With improvements in early detection, surgery, and adjuvant therapy for breast cancer, long-term survival and cure are becoming possible. Despite providing longer survival with early diagnosis of breast cancer, the treatment leaves sequelae with adverse effects such as influence on functional capacity, fatigue, depression, neuropathic lymphoedema, low immunity, and loss of flexibility. All of these effects end up affecting the quality of life (QoL), Imbalance, gait dysfunction, and falls may have particularly severe consequences in breast cancer survivors due to comorbidities increasing the risk of fall-related injury, secondary decline in physical activity, and subsequent functional decline.

Given the profound effects that imbalance, gait dysfunction, and falls have on functional independence, QOL, and long-term health and survivorship, the treatment or prevention of these symptoms is an essential component of cancer rehabilitation for all survivors.

Furthermore, the need for this study is developed from the lack of quantitative knowledge and information in the published studies about the effect of Circuit Weight Training (CWT) on functional capacity and quality of life in breast cancer patients.

Eligibility criteria: Inclusion Criteria:

* Female with age between 35-45.
* Body Mass Index (BMI) \< 25.
* Patients diagnosed with non-metastatic (Stage 0-III) breast cancer.
* All patients who are treated by neoadjuvant chemotherapy before surgery.

Exclusion Criteria:

* Patients diagnosed with cancer metastasis.
* Patients diagnosed with diseases of the nervous system (Parkinson's disease, peripheral nerve palsy) skeletal system (inflammatory diseases, scoliosis \>10 Cobb angle), or rheumatic diseases.
* Patients with any current visual impairment that affected their daily living, vestibular disorder, neurological disorder, cognitive disorder, and any further medical condition that would prohibit them from participating safely.

Primary outcomes:
measure: Assessment of quality of life
timeFrame: 8 weeks
measure: Assessment of functional capacity
timeFrame: 8 weeks
Secondary outcomes:
measure: Postural stability test
timeFrame: 8 weeks
measure: Limits of stability test
timeFrame: 8 weeks
measure: Single leg stability test
timeFrame: 8 weeks
measure: Assessment of muscle strength
timeFrame: 8 weeks
Other outcomes:
Locations:
city: Giza
country: Egypt
facility: Alhasnaa Sayed Farouk
Study officials:
affiliation: Cairo University
name: Maher H Ibrahim, Professor
role: STUDY_DIRECTOR
affiliation: Cairo University
name: Heba A. Abdulghafar, Professor
role: STUDY_CHAIR
References: