louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT04902118: Burnout Determinants Among Pediatric Psychiatry Workers During COVID-19 Crisis
Official title: Burnout Determinants Among Pediatric Psychiatry Workers During COVID-19 Epidemic in Occitanie Region in France
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Burnout
Keywords: Burnout status
Lead sponsor: University Hospital, Montpellier
Sponsor class: OTHER
First posted: 2021-05-26
Enrollment: 300
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: RETROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Medical and paramedical workers in the field of Pediatric Psychiatry in the Occitanie region

Brief summary: Burnout among health workers is at core of our current preoccupations because of the health crisis we're going trough. Indeed, COVID-19 epidemic had terrible consequences not only on global mental health both in adults and children, but also on Health workers mental health. The investigators chose to consider Pediatric Psychiatry workers because of their particular position in this crisis.

The aim of the study is to point out burnout determining factors among Pediatric Psychiatry workers in Occitanie during COVID-19 crisis, by the use of an online questionnaire including the Copenhagen Burnout Inventory.


Eligibility criteria: Inclusion criteria:

- Medical doctors, interns, Paramedics (nurse, assistant nurse), Psychologists, Caseworkers working \> 50% in a structure medico socio sanitaire

Exclusion criteria:

- Other persons working in a in a structure medico socio sanitaire

Primary outcomes:
measure: Copenhagen Burnout Inventory
timeFrame: 1 day
Secondary outcomes:
measure: Epidemic attribuable stress proportion
timeFrame: 1 day
Other outcomes:
Locations:
city: Montpellier
country: France
facility: Uhmontpellier
Study officials:
affiliation: UH Montpellier
name: Diane Purper-Ouakil, M.D., Ph. D.
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT01918618: Renal Effects of Levosimendan in Cardiac Surgery Patients
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Treatment of Left Heart Insufficiency in an Operative Setting of Cardiac Surgery
Keywords: levosimendan
renal effects
cardiac surgery
left heart insufficiency
Lead sponsor: Charite University, Berlin, Germany
Sponsor class: OTHER
First posted: 2013-08-08
Enrollment: 92
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: CASE_CONTROL
Time perspective: RETROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: Patients undergoing cardiac surgery between 2007 and 2011 followed by postoperative observation on an ICU of the anaesthesiology department of the Charité hospital

Brief summary: Recent experimental and clinical data suggest a benefit of levosimendan on the kidney function. Therefore, this retrospective, single center, matched-pairs analysis aimed to investigate whether administration of levosimendan was associated with improved renal function in cardiac surgery patients.


Eligibility criteria: Inclusion Criteria:

* Patients undergoing cardiac surgery (OPS 5-35 bis 5-37) between 2007 and 2011 followed by postoperative observation on an ICU of the anaesthesiology department of the Charité hospital

Exclusion Criteria:

* Patients younger 18
* Preexisting renal insufficiency

Primary outcomes:
measure: Change of plasma creatinine (Difference in renal function)
timeFrame: last available value pre-op (baseline), first available value on post-op day 1, 2, 3 and 4
measure: Change of urine output after surgery (difference in renal function)
timeFrame: post-op day 1, 2, 3, 4
measure: Cumulative incidence and duration of hemodialysis (Difference in renal function)
timeFrame: last day of hospital stay
Secondary outcomes:
measure: Cumulative Length of stay (hospital and ICU)
timeFrame: last day of hospital stay
measure: In-hospital mortality
timeFrame: last day of hospital stay
Other outcomes:
Locations:
city: Berlin
country: Germany
facility: Charité - University Medicine Berlin
Study officials:
References:
citation: Mehta RL, Kellum JA, Shah SV, Molitoris BA, Ronco C, Warnock DG, Levin A; Acute Kidney Injury Network. Acute Kidney Injury Network: report of an initiative to improve outcomes in acute kidney injury. Crit Care. 2007;11(2):R31. doi: 10.1186/cc5713.
citation: Yakut N, Yasa H, Bahriye Lafci B, Ortac R, Tulukoglu E, Aksun M, Ozbek C, Gurbuz A. The influence of levosimendan and iloprost on renal ischemia-reperfusion: an experimental study. Interact Cardiovasc Thorac Surg. 2008 Apr;7(2):235-9. doi: 10.1510/icvts.2007.161356. Epub 2007 Dec 3.
citation: Balzer F, Treskatsch S, Spies C, Sander M, Kastrup M, Grubitzsch H, Wernecke KD, Braun JP. Early administration of levosimendan is associated with improved kidney function after cardiac surgery - a retrospective analysis. J Cardiothorac Surg. 2014 Nov 18;9:167. doi: 10.1186/s13019-014-0167-8.
Clinical trial NCT05952713: Comparative Responses to 15 Different Antidepressants in Major Depressive Disorder
Official title: Comparative Responses to 15 Different Antidepressants in Major Depressive Disorder - Results From a Long-term Nation-wide Population-based Study Emulating a Randomized Trial
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Major Depressive Disorder
Lead sponsor: Mental Health Services in the Capital Region, Denmark
Sponsor class: OTHER
Collaborators: name: University of Copenhagen
First posted: 2023-07-19
Enrollment: 73336
Sex: ALL
Minimum age (years): 18
Maximum age (years): 100
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: RETROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Patients with a psychiatric contact (as inpatients or outpatients) in the period from 1995 to 2018 with a first main index diagnosis of a single depressive episode or recurrent depressive disorder (ICD-10 code: F32-F33.9) with an outpatient purchase of an antidepressant after the depression diagnosis (N=73.336).

Brief summary: Achieving results from RCTs with high internal and external validity is a major challenge within psychiatry due to the nature of psychiatric illnesses. The Investigators will conduct a "real world" naturalistic nation-wide population-based longitudinal register linkage study comparing long-term responses to all kinds of antidepressants in patients with major depressive disorder emulating a randomized trial.


Eligibility criteria: Inclusion Criteria:

All patients with a psychiatric contact (as inpatients or outpatients) in the period from 1995 to 2018 with a first main index diagnosis of a single depressive episode or recurrent depressive disorder (ICD-10 code: F32-F33.9) with an outpatient purchase of an antidepressant after the depression diagnosis (N=73.336).

Exclusion Criteria:

None.

Primary outcomes:
measure: Response
timeFrame: 2 years
Secondary outcomes:
Other outcomes:
Locations:
city: Copenhagen
country: Denmark
facility: Psychiatric Center Copenhagen
Study officials:
References:
Clinical trial NCT00665613: The Relationship Between Osteoporosis and Chronic Oral Anticoagulation Therapy With Warfarin
Official title: The Relationship Between Osteoporosis and Chronic Oral Anticoagulation Therapy With Warfarin
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Osteoporosis
Keywords: warfarin use
Lead sponsor: Northwell Health
Sponsor class: OTHER
Collaborators: name: Staten Island University Hospital
First posted: 2008-04-24
Enrollment: 300
Sex: ALL
Minimum age (years): 18
Maximum age (years): 100
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: CASE_ONLY
Time perspective: RETROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: patients on warfarintherapy in the SIUH coumadin center

Brief summary: The purpose of this study is to determine if osteoporosis is an unrecognized complication of chronic anticoagulation with warfarin.


Eligibility criteria: Inclusion Criteria:

* Patients on warfarin that have had BMD within a year

Exclusion Criteria:

* Patients on bisphosphates, SERMS, anticonvulsants, estrogens, androgens, calcitonin, hctz and thyroid hormone replacement

Primary outcomes:
measure: Bone Density
timeFrame: 5 to 10 years
Secondary outcomes:
Other outcomes:
Locations:
city: Staten Island
country: United States
facility: Staten Island University Hospital
state: New York
Study officials:
References:
Clinical trial NCT06615713: Evaluate the Safety and Effectiveness of Steerable Ureteroscopic Renal Evacuation (SURE) Using the CVAC® System
Official title: A Prospective Study to Evaluate the Safety and Effectiveness of Steerable Ureteroscopic Renal Evacuation (SURE) Using the CVAC® Set
Study type: INTERVENTIONAL
Overall status: ACTIVE_NOT_RECRUITING
Phase: NA
Conditions: Renal Stones
Kidney Stone
Urolithiasis
Lead sponsor: Calyxo, Inc.
Sponsor class: INDUSTRY
First posted: 2024-09-27
Enrollment: 40
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: TREATMENT

Brief summary: The purpose of the study is to assess safety and efficacy of a novel steerable ureteral catheter system, the CVAC System for the treatment of urinary stones.


Eligibility criteria: Inclusion Criteria:

* Candidate for ureteroscopy with laser lithotripsy;
* Be willing and able to return for and respond to all study-related follow up procedures; and,
* Have been informed of the nature of the study and have agreed to the IRB approved informed consent form (ICF).

Exclusion Criteria:

* Significant morbidities;
* Unable to meet the treatment and follow up protocol requirements; and,
* Ureteral or kidney abnormalities.

Primary outcomes:
measure: Stone Clearance
timeFrame: Day 1 and Day 30
Secondary outcomes:
Other outcomes:
Locations:
city: Nadiad
country: India
facility: Muljibhai Patel Urological Hospital
Study officials:
References:
Clinical trial NCT03029013: Apatinib and Chemotherapy Sequential Treatment With Cervical Cancer
Official title: A Phase II Clinical Trial Study on Apatinib and Chemotherapy Sequential Treatment With Advanced Metastatic Cervical Cancer
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Cervical Cancer
Lead sponsor: Third Military Medical University
Sponsor class: OTHER
First posted: 2017-01-23
Enrollment: 30
Sex: FEMALE
Minimum age (years): 25
Maximum age (years): 75
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: TREATMENT

Brief summary: The study is the single arm and single center clinical trials，We conduct the phase II clinical trial to further explore the efficacy and safety of Apatinib and chemotherapy sequential treatment with advanced recurrence of metastatic cervical cancer


Eligibility criteria: Inclusion Criteria:

* The pathological diagnosis of recurrent or metastatic cervical cancer;
* Eastern Cooperative Oncology Group (ECOG) performance status of 0 - 1;
* Life expectancy of more than 3months;
* With normal marrow, liver and renal function：

  * blood routine examination ：HB≥90g/L，ANC ≥1.5×10\*9/L，PLT≥80×10\*9/L；
  * Biochemical examination: total bilirubin (TBil) of ≤1.5 upper normal limitation (UNL)，alanine aminotransferase (ALT) and aspartate aminotransferase (AST) of ≤2.5 UNL or ≤5 UNL ，acreatinine (Cr) of ≤ 1.25 UNL; creatinine clearance rate ≥ 45ml/min (Cockcroft-Gault);
* With written informed consent signed voluntarily by patients themselves .
* With good compliance and agree to accept follow-up of disease progression and adverse events.

Exclusion Criteria:

* Uncontrolled hypertension
* Suffered from grade II or above myocardial ischemia or myocardial infarction, uncontrolled arrhythmias
* With abnormal coagulation function， bleeding tendency or treating with thrombolysis and anticoagulation
* History of clinically relevant major bleeding event (e.g. gastrointestinal hemorrhage, bleeding ulcer, occult blood ≥ (++), and vasculitis) =\< 3 months prior to randomization;
* uncured the wound or fracture
* Centrally located tumors of local invasion of major blood vessels, or Researchers think that patients may invade the important blood vessels and cause fatal bleeding (CT or MRI);
* Factors affecting the oral medication (e.g. inability to swallow, chronic diarrhea and intestinal obstruction);
* Urine protein \>++, or urine protein in 24 hours\> 1.0g
* Accumulation of coelomic fluid (e.g. pleural effusion, ascites fluid, cardiac effusion) requiring treatment
* History of uncontrolled psychotropic drug abuse or mental disorders;
* Prior VEGFR inhibitor treatment ;
* Other malignancy within Before or at the same time other than basal cell skin cancer, or carcinoma in situ of the cervix;

Primary outcomes:
measure: Progression free survival
timeFrame: 24 months
Secondary outcomes:
measure: overall survival
timeFrame: 24 months
Other outcomes:
Locations:
city: Chongqing
country: China
facility: Daping Hospital, Third Military Medical University
state: Chongqing
Study officials:
References:
Clinical trial NCT03807713: Clinical Study of Minimally Invasive Ponto Surgical Technique (MIPS) - Design Iteration
Official title: Clinical Study of Minimally Invasive Ponto Surgical Technique (MIPS) - Design Iteration
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Bone Conduction Deafness
Unilateral Deafness
Middle Ear Deafness
Mixed Hearing Loss
Lead sponsor: Oticon Medical
Sponsor class: INDUSTRY
First posted: 2019-01-17
Enrollment: 25
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: TREATMENT

Brief summary: The objective of the study is to compare the outcomes after a surgical procedure with minimally invasive Ponto surgery (MIPS, test group) and tissue preservation surgery (control) for placing Oticon Medical Ponto implants and abutments.


Eligibility criteria: Inclusion Criteria:

* 18 years or older.
* Patient indicated for an ear level bone anchored sound processor.
* Healthy bone quality to allow for 4mm implant insertion.

Exclusion Criteria:

* Intraoperative switch to an alternative surgical technique
* Patients undergoing re-implantation (on the side being included in the study)
* Previous participation in the C47 study.
* Inability to participate in follow-up.
* Psychiatric disease in the medical history.
* Mental disability.
* Presumed doubt, for any reason, that the patient will be able to show up on all follow-ups.
* Diseases or treatments known to compromise the bone quality at the implant site, e.g. radiotherapy, osteoporosis, diabetes mellitus.
* Patients with natural skin height of \>12mm (as there will be additional skin reduction needed)

Primary outcomes:
measure: Numbness (sensibility) around the implant
timeFrame: 6 months post surgery
Secondary outcomes:
measure: Length of surgery
timeFrame: At surgery
measure: Unplanned visits
timeFrame: 36 months
measure: Adverse skin reactions
timeFrame: 36 months
measure: Adverse skin reactions
timeFrame: 36 months
measure: Pain perception by patient
timeFrame: 36 months
measure: Implant survivability
timeFrame: 36 months
measure: Implant stability as measured with resonance frequency analysis, RFA.
timeFrame: 36 months
measure: Surgical wound healing time
timeFrame: 36 months
measure: Wound dehiscence
timeFrame: 36 months
measure: Quality of Life Assessment
timeFrame: 36 months
measure: Quality of Life Assessment
timeFrame: 36 months
measure: Quality of Life Assessment
timeFrame: 36 months
measure: Quality of Life Assessment
timeFrame: 36 months
measure: Quality of Life Assessment
timeFrame: 36 months
Other outcomes:
Locations:
city: Nijmegen
country: Netherlands
facility: Radboud University Medical Center
Study officials:
affiliation: Radboud UMC, Department of Otorhinolaryngology. The Netherlands
name: Myrthe Hol, MD, PhD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT05171413: Predictive Models of Treatment Responses and Survival Outcomes in Patients With Soft Tissue Sarcoma
Official title: Predictive Models of Treatment Responses and Survival Outcomes in Patients With Soft Tissue Sarcoma
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Soft Tissue Sarcoma
Lead sponsor: West China Hospital
Sponsor class: OTHER
First posted: 2021-12-28
Enrollment: 800
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: OTHER
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Patients with soft tissue sarcoma who were diagnosed histologically with definite pathologic specimens.

Brief summary: The aim of this study was to developed and validated models to predict therapeutic responses and patients' survivals in patients with soft tissue sarcoma and compared these models with currently available models.

Detailed description: We performed a retrospective-prospective cohort study with the aim of developing and validating comprehensive models to predict treatment responses and survival outcomes in patients with biopsy-proven soft tissue sarcoma. Secondly, we aimed to compare the predictive accuracy with currently available noninvasive model.

Eligibility criteria: Inclusion Criteria:

* Receiving no treatment before diagnosis
* With written informed consent

Exclusion Criteria:

* Clinical data missing
* Without written informed consent

Primary outcomes:
measure: Treatment response
timeFrame: At least 1-year follow up
measure: Progression-free survival outcomes
timeFrame: At least 5-year follow up
measure: Overall survival outcomes
timeFrame: At least 5-year follow up
Secondary outcomes:
Other outcomes:
Locations:
city: Chengdu
country: China
facility: West China Hospital, Sichuan University
state: Sichuan
Study officials:
References:
Clinical trial NCT06007313: Mental Stress and Bowel Preparation Quality
Official title: A Cross-sectional Study of the Relationship Between Mental Stress and Bowel Preparation
Study type: OBSERVATIONAL
Overall status: RECRUITING
Conditions: Colonoscopy
Intestinal Disease
Lead sponsor: RenJi Hospital
Sponsor class: OTHER
First posted: 2023-08-23
Enrollment: 1000
Sex: ALL
Minimum age (years): 18
Maximum age (years): 75
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: CASE_CONTROL
Time perspective: CROSS_SECTIONAL
Sampling method: PROBABILITY_SAMPLE
Study population: Patients who underwent colonoscopy from May 2023-August 2023 at the Endoscopy Centre, Renji East Hospital.

Brief summary: The goal of this cross-sectional study was to explore the relationship between physical and psychological stress and the quality of bowel preparation before a colonoscopy examination, in order to improve the quality of bowel preparation.

The main questions it aims to answer are:

Does physical and psychological stress affect the quality of colonoscopic bowel preparation, and delay disease detection? How can we improve the quality of colonoscopy？ Participants will be asked to complete a questionnaire containing their demographics, history of diseases and drugs, lifestyle habits, and physical and 14-item perceived stress scale(PSS-14). Quality of bowel preparation was assessed by the Boston bowel preparation scale（BPS）.

Detailed description: A total of 1000 patients who were to undergo colonoscopy at the Endoscopy Centre of the Department of Gastroenterology, Renji Hospital, from May 2023 to August 2023 were collected, and the general information and the physical and mental stress test scale of the patients were collected by questionnaires from random samples, and they were screened for enrolment according to the inclusion and exclusion criteria. The correlation between physical and mental stress and the quality of bowel preparation for colonoscopy was analyzed according to the Boston Rating Scale (BPS), which is used by colonoscopists to assess the quality of bowel preparation for each patient.

Eligibility criteria: Inclusion Criteria:

* Participants aged 18 to 75 years old with an indication for colonoscopy
* Participants signed an informed consent form for colonoscopy and underwent colonoscopy
* Participants not be with a history of digestive tumors, active inflammatory bowel disease and other conditions that significantly affect colonic motility
* Participants with good communication and comprehension skills and be able to answer assessment questions accurately

Exclusion Criteria:

* Withdrawal prior to colonoscopy
* Incomplete completion of information

Primary outcomes:
measure: The quality of bowel preparation
timeFrame: During colonoscopy, about 20 minutes
Secondary outcomes:
Other outcomes:
Locations:
city: Shanghai
country: China
facility: Renji Hospital, School of Medicine, Shanghai Jiao Tong University
state: Shanghai
Study officials:
References:
Clinical trial NCT06912113: The Effect of Motivational ınterviewing on ıntention to Quit Smoking in Lung Cancer Patients
Official title: The Effect of Motivational Interviewing on Smoking Quit Intention in Lung Cancer Patients: a Randomized Controlled Trial
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Smoking Cessation
Motivational Enhancement
İntention to Quit
Keywords: Motivational enhancement
Real-time video counselling
Lung cancer
İntention to quit smoking
Lead sponsor: University of Gaziantep
Sponsor class: OTHER
First posted: 2025-04-04
Enrollment: 42
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Intervention model description: randomized controlled trial
Primary purpose: TREATMENT

Brief summary: The effect of online video conferencing on smoking cessation intention in patients diagnosed with lung cancer was investigated.


Eligibility criteria: Inclusion Criteria:

* Patients over the age of 18,
* diagnosed with lung cancer, who had smoked at least 100 cigarettes in their lifetime and had smoked at least one cigarette in the last month,
* who volunteered to participate in the study,
* who had no communication problems, and who had internet access were included in the study.

Exclusion Criteria:

* Occasional smokers,
* Those using a different type of nicotine than cigarettes,
* Those actively participating in other smoking cessation programs, and those reporting dependence on any medication were excluded from the study.

Primary outcomes:
measure: Intention to quit smoking scale
timeFrame: Four weeks
Secondary outcomes:
Other outcomes:
Locations:
city: Gaziantep
country: Turkey
facility: Gaziantep University
Study officials:
References: