Clinical trial NCT01923454: Immediate Anterior Chamber Paracentesis With A 30-Gauge Needle for Acute Primary Angle - Closure
Official title: Immediate Anterior Chamber Paracentesis With A 30-Gauge Needle for Acute Primary Angle - Closure
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Glaucoma, Angle-closure
Keywords: paracentesis
primary acute angle closure
iridotomy
filtration
glaucoma
Lead sponsor: Siriraj Hospital
Sponsor class: OTHER
First posted: 2013-08-15
Enrollment: 15
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: TREATMENT

Brief summary: This study was to evaluate the efficacy and safety of immediate anterior chamber paracentesis (ACP) with a 30-gauge needle as an initial treatment for acute primary angle closure (APAC).

Detailed description: This is a prospective study from patients with APAC presenting at the Faculty of Medicine Siriraj Hospital, Bangkok, Thailand in 2005. At presentation, patients received immediate ACP with a 30-gauge needle. The IOP, best corrected visual acuity (BCVA), corneal edema grading, pupil size and symptoms were recorded at immediately, 15 and 30 minutes, and then 1, 24 and 48 hours after paracentesis. All affected eyes received antiglaucomatous medications 60 minutes after ACP and underwent peripheral iridotomy within 24 hours.

Eligibility criteria: Inclusion Criteria:

* patients aged more than 18 year old with the first attack of APAC
* IOP of more than or equal to 40 mmHg.

Exclusion Criteria:

* patient unable to cooperate for paracentesis
* patients with APAC in the only remaining eye
* patients received any glaucoma treatments prior to the study
* patients with secondary causes of acute angle closure
* patients with intraocular inflammation or infection; (6) patients with APAC in the eye with a history of previous intraocular surgery
* patients known hypersensitive to tetracaine hydrochloride or tobramycin.

Primary outcomes:
measure: The Intraocular pressure (mmHg)
timeFrame: Change of intraocular pressure between before paracentesis and at 48 hours after paracentesis
Secondary outcomes:
measure: Numbers of complications
timeFrame: at immediately(within 2 minutes after paracentesis), 15 and 30 minutes, and then 1, 24 and 48 hours after paracentesis.
Other outcomes:
measure: visual acuity
timeFrame: The change of visual acuity between before paracentesisat and immediately (within 2 minutes) after paracentesis, 1 hours, 24 hours and 48 hours after paracentesis
Locations:
city: Bangkok
country: Thailand
facility: Naris Kitnarong
Study officials:
affiliation: Mahidol University
name: Naris Kitnarong, M.D.
role: PRINCIPAL_INVESTIGATOR
References:
citation: Pong JC. Anterior chamber paracentesis in patients with acute elevation of intraocular pressure. Graefes Arch Clin Exp Ophthalmol. 2008 Mar;246(3):463-4; author reply 465-6. doi: 10.1007/s00417-007-0675-5. Epub 2007 Dec 11. No abstract available.
citation: Lam DS, Chua JK, Tham CC, Lai JS. Efficacy and safety of immediate anterior chamber paracentesis in the treatment of acute primary angle-closure glaucoma: a pilot study. Ophthalmology. 2002 Jan;109(1):64-70. doi: 10.1016/s0161-6420(01)00857-0.