Clinical trial NCT05591313: Acute Exercise on Neurocognitive Function Among Adults With/Without Generic Risk of AD
Official title: Acute Exercise Effect on Neurocognitive Function Among Cognitively Normal Late-Middle-Aged Adults With/Without Generic Risk of Alzheimer's Disease: The Moderation Role of Exercise Volume and Apolipoprotein E Genotype
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Alzheimer Disease 2 Due to Apoe4 Isoform
Keywords: aerobic exercise
APOE genotype
event-related potential
executive function
exercise prescription
Lead sponsor: National Taiwan Normal University
Sponsor class: OTHER
First posted: 2022-10-24
Enrollment: 51
Sex: ALL
Minimum age (years): 50
Maximum age (years): 70
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: FACTORIAL
Intervention model description: The present study adopted a counterbalanced design. All participants were instructed to complete four counterbalanced treatments: a) longer duration (LI-40), b) moderate-intensity with 30 min (MI-30), c) high-intensity with shorter duration (HI-16), and d) control treatments.
Primary purpose: TREATMENT

Brief summary: This study explores the acute exercise effect on neurocognitive function and also its potential moderators in an exercise setting and Apolipoprotein E (APOE) genetic risk.

Detailed description: Acute exercise has emerged as a modifier to multiple aspects of cognitive function; however, its effect on populations with different risks of Alzheimer's disease (AD) and the role of exercise variance and APOE genotype within the effect reminds underestimated. The current study aimed to examine the acute exercise effect on neurocognitive function from behavioral and neuroelectric perspectives among cognitively normal late-middle-aged adults. Additionally, we determined whether variations in exercise intensity and duration and the presence of the APOE ɛ4 allele modulated the effect.

Eligibility criteria: Inclusion Criteria:

1. Adults aged between 50 and 70 years old
2. Normal or corrected-to-normal vision based on the minimal 20/20 standard
3. Cognitively normal as mini-mental state examination scores (MMSE) \> 26

Exclusion Criteria:

1. Neurological or psychiatric disorders
2. Cardiovascular disease
3. Risk of cardiovascular fitness assessment based on the Physical Activity Readiness Questionnaire (PAR-Q)
4. Red-green color blindness.

Primary outcomes:
measure: Stroop task: Response time
timeFrame: Participants were required to complete the Stroop task approximately 30 min following the cessation of each acute exercise treatment or the 30-min reading.
measure: Stroop task: Accuracy
timeFrame: Participants were required to complete the Stroop task approximately 30 min following the cessation of each acute exercise treatment or the 30-min reading.
measure: Event-related potential: P3 amplitude
timeFrame: Participants were required to complete the Stroop task while EEG activity was continuously recorded approximately 30 min following the cessation of each acute exercise treatment or the 30-min reading.
Secondary outcomes:
Other outcomes:
Locations:
city: Taipei
country: Taiwan
facility: Department of Physical Education and Sport Sciences, National Taiwan Normal University
Study officials:
affiliation: Department of Physical Education and Sport Sciences, National Taiwan Normal University
name: Yu-Kai Chang, Ph.D.
role: STUDY_DIRECTOR
References: