Clinical trial NCT00843219: Motion Correction of Positron Emission Tomography (PET) Data Using Amplitude Gating
Official title: Motion Correction of Positron Emission Tomography (PET) Data Using Amplitude Gating
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Lung Cancer
Keywords: Lung
Lung Cancer
Non-small cell Lung Cancer
NSCLC
Motion Correction
PET/CT Scan
PET
Positron Emission Tomography
CT
Computed Tomography
Amplitude Gating
Lead sponsor: M.D. Anderson Cancer Center
Sponsor class: OTHER
Collaborators: name: GE Healthcare
First posted: 2009-02-13
Enrollment: 12
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: CASE_ONLY
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Individuals over the age of 18 with non-small cell lung cancer (NSCLC) and are scheduled to have a positron emission tomography/computed tomography (PET/CT) scan.

Brief summary: Objectives:

Evaluation of an amplitude based gated Positron Emission Tomography (PET) data acquisition system for all GE Discovery Positron Emission Tomography/ Computed Tomography (PET/CT) scanners.

Detailed description: Routine PET/CT scans are taken while patients are breathing normally. The motions made by breathing can reduce the image quality of the scan. Minimizing the effects of this motion by taking the images and processing the scans differently may improve the image quality.

The PET/CT Scan:

If you agree to take part in this study, an elastic belt will be placed around your lower chest/upper abdomen before your routine PET/CT scan. This belt is used to track your breathing motion. This information will be used to help process the scan.

Your PET/CT scan will be performed as usual. During the scan, researchers will focus on your lower chest/upper abdomen (areas that experience breathing motion). Having to focus on this area might extend the scan by up to 10 minutes.

The additional scan time will not increase your radiation exposure since only PET scanning will be performed.

Length of Study:

Your participation on this study will be complete when your scheduled PET/CT scan is complete.

This is an investigational study. The imaging focused on your lower chest/upper abdomen during the scan is investigational.

Up to 26 patients will take part in this study. All will be enrolled at M. D. Anderson.

Eligibility criteria: Inclusion Criteria:

1. Patients with lung or liver lesions measuring 0.5-2cm in diameter will be considered.
2. Patients that are scheduled to be imaged in the PET/CT suite at the Mays Building will only be considered.

Exclusion Criteria:

1. Pediatric patients (younger than 18 years) will be excluded.
2. Patients that cannot tolerate being scanned for an additional 10 minutes with arms above their head will be excluded.

Primary outcomes:
measure: Mean Difference Between Gated + Ungated PET/CT Scans
timeFrame: Scheduled PET/CT scans extended by 10 minutes
Secondary outcomes:
Other outcomes:
Locations:
city: Houston
country: United States
facility: UT MD Anderson Cancer Center
state: Texas
Study officials:
affiliation: UT MD Anderson Cancer Center
name: Osama R Mawlawi, PHD
role: PRINCIPAL_INVESTIGATOR
References: