louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT05794334: Low Dye Taping Technique Versus Robert Debre Method On Foot Posture And Range Of Motion In Children With Club Foot.
Official title: Effects Of Low Dye Taping Technique Versus Robert Debre Method On Foot Posture And Range Of Motion In Children With Club Foot.
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Club Foot
Keywords: Low dye taping
Robert Debre tecnique
Lead sponsor: Riphah International University
Sponsor class: OTHER
First posted: 2023-04-03
Enrollment: 40
Sex: ALL
Minimum age (years): 1
Maximum age (years): 6
Standard ages: CHILD
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: To Check the effects of the low dye taping technique versus the Robert Debre method on foot posture and range of motion in children with club feet.

Detailed description: This study was a Randomized clinical trial. It was carried out in the physiotherapy department of children hospital Lahore,those patients were taken who had congenital clubfoot.40 patients were taken with the predetermined inclusive and exclusive criteria through non probability convenience sampling technique.All participants informed about the study,Group A received Low Dye taping Technique 2 times in a week for 6 weeks,while the group B received the Robert Debre Methpod daily 30 minutes session for total 6 weeks.Foot posture, range of motion and gait will be assessed by Demiglio bensahel and pirani scoring system with the help of goniometer and compared the results.Data analyzed by SPSS 25.0 statistical software. After checking the normality of data nonparametric tests applied to check the difference between and within the groups.

Eligibility criteria: Inclusion Criteria:

1. (1month to 6months ).
2. Children having idiopathic club foot
3. Unilateral or bilateral
4. Severity by Dimeglio Bensahel scale we include moderate ,severe and very severe feet

Exclusion Criteria:

1. Benign or non idiopathic.
2. An associated syndrome or neurological disease.
3. Positional club foot.
4. Those previously treated with another method in other hospitals.
5. Children with systemic diseases.
6. Juvenile Arthritis.

Primary outcomes:
measure: The Pirani scale:
timeFrame: 6th week
measure: The Dimeglio Bensahel Classification:
timeFrame: 6th week
Secondary outcomes:
Other outcomes:
Locations:
city: Lahore
country: Pakistan
facility: Children hospital
state: Punjab
Study officials:
affiliation: Riphah international university pakistan
name: fareeha kausar, pp-Dpt
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT01946334: Does Body Position Influence Pressure Recording by High-resolution Manometry ?
Official title: Does Body Position Influence Pressure Recording by High-resolution Manometry ?
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Anal Incontinence or Constipation
Lead sponsor: Assistance Publique Hopitaux De Marseille
Sponsor class: OTHER
First posted: 2013-09-19
Enrollment: 40
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: DIAGNOSTIC

Brief summary: The anorectal manometry is the gold standard in the evaluation of anorectal function.

Several techniques are currently used (balloons, perfused catheters) and are always performed in the supine position.

Few studies have reported the evaluation of sphincter function in the upright position, whereas symptoms of fecal incontinence occur in this position.

Recently developed, high-resolution manometry, thanks to its many mechanical sensors, allows topographic analysis and evaluation of anorectal function more acurate. In addition, the rigid nature of the probe should allow stability measures / recording, which is not possible with probes perfused catheters example.

We therefore propose to compare anal sphincter pressure in supine and standing, measured in high-resolution manometry.


Eligibility criteria: Inclusion Criteria:

* Man or woman over the age of 18 years
* Patient referred for endoscopic ultrasound and anal manometry anorectal HR-3D which is an indication of fecal incontinence or dyschesia

Exclusion Criteria:

* Patient age 18 Less
* Patient trust, guardianship, judicial protection
* No Written Consent
* Lack of social insurance
* History of anorectal surgery
* A presence of anal stenosis
* A setting evidence of anorectal lesion preventing the realization of the Screening
* Motor disability preventing the realization of the anorectal manometry 3D HR-standing situation

Primary outcomes:
measure: anal pressures measured by anorectal manometry and high-resolution three-dimensional
timeFrame: 12 months
Secondary outcomes:
Other outcomes:
Locations:
city: Marseille
country: France
facility: Assistance Publique Hopitaux de Marseille
Study officials:
affiliation: Assistance Publique Hopitaux De Marseille
name: LOIC MONDOLONI
role: STUDY_DIRECTOR
References:
Clinical trial NCT06830434: Aesthetic Crown Lengthening: Laser Impact on Pain Perception and Perceptions on Self-esteem and Quality of Life
Official title: Aesthetic Crown Lengthening: Laser Impact on Pain Perception and Surgery Impact on Self-esteem and Quality of Life Perceptions
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Crown Lengthening
Pain Postoperative
Self Concept
Lead sponsor: University of Campinas, Brazil
Sponsor class: OTHER
First posted: 2025-02-17
Enrollment: 20
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Intervention model description: Twenty patients will be selected based on their interest in undergoing aesthetic crown lengthening surgery in the anterior maxillary region and their indication for the procedure. Two questionnaires will be administered: the OHIP-14/Brazil and the Rosenberg Self-Esteem Scale - UNIFESP/EPM. In one study arm, laser therapy will be performed in a blinded manner immediately after the surgical procedure.
Primary purpose: TREATMENT

Brief summary: Gummy smile is a condition that promotes a disharmonious smile, altering confidence and decreasing self-esteem of many patients. Luckily, this problem in most cases is easily solved by aesthetic crown lengthening surgery. However, this is a surgery that is still considered by many patients to be painful and uncomfortable. Thereby, this study seeks both to evaluate possible changes in patients' self-esteem and self-confidence after the aesthetic crown lengthening surgery.

Detailed description: Periodontally healthy patients who expressed interest in undergoing ACL will be selected. Before surgery, two questionnaires will be administered: the OHIP-14/Brazil and the Rosenberg Self-Esteem Scale-UNIFESP/EPM. These tools are designed to assess patients' perceptions of self-esteem and quality of life and will be re-administered 30 days and one year after surgery.

Eligibility criteria: Inclusion Criteria:

* Periodontal health diagnosis (full mouth bleeding on probing - BP \<10%, clinical attachment level - CAL ≤ 3mm),
* Distance from the gingival margin to the cementum-enamel junction ≥ 3mm associated with a gingival smile and / or short clinical crowns when compared to anatomical crowns, due to the altered passive eruption or gingival overgrowth).
* Good general health

Exclusion Criteria:

* Presence of systemic changes (diabetes, heart disease, hepatitis, etc.)
* Use of medications (such as antibiotics, continuous anti-inflammatory drugs, phenytoin, cyclosporine) that may influence the response to the surgical treatment
* Diagnosis of gingivitis and/or periodontitis
* Smoking habit
* Pregnancy or lactation period

Primary outcomes:
measure: Patients' levels of self-esteem and quality of life
timeFrame: From enrollment through study completion, an average of 2 years
Secondary outcomes:
Other outcomes:
Locations:
city: Piracicaba
country: Brazil
facility: University of Campinas, UNICAMP
state: São Paulo
Study officials:
References:
Clinical trial NCT05195034: Effect of Dexmedetomidine on Postoperative Delirium After Awake Craniotomies
Official title: Effect of Dexmedetomidine on Postoperative Delirium in Patients Undergoing Awake Craniotomies: a Randomized Controlled Trial
Study type: INTERVENTIONAL
Overall status: RECRUITING
Phase: NA
Conditions: Dexmedetomidine
Delirium
Awake Craniotomy
Lead sponsor: Beijing Tiantan Hospital
Sponsor class: OTHER
First posted: 2022-01-18
Enrollment: 210
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: PREVENTION

Brief summary: Postoperative delirium (POD) is a common complication, and the incidence of POD ranges from 10% to 60%. Previous studies suggested that frontal approach and tumor located at the temporal lobe were independent risk factors for POD after supratentorial tumor resections. Therefore, patients undergoing awake craniotomies are high-risk populations for POD. A lot of trials show that dexmedetomidine might help to reduce the incidence of delirium in patients undergoing non-cardiac surgery. However, the impact of dexmedetomidine (DEX) on POD for patients undergoing awake craniotomies remains unclear. The purpose of this study was to investigate the effect of DEX on POD in patients undergoing awake craniotomies.


Eligibility criteria: Inclusion Criteria:

* Patients undergoing selective awake craniotomies.
* Age ≥18 years.
* Obtain written informed consent.

Exclusion Criteria:

* 1.Preoperative moderate and severe cognitive impairment (Montreal Cognitive Assessment, MoCA\< 18).
* 2.Preoperative psychotropic medication within one year.
* 3.BMI≤18 or ≥30 Kg/ m2
* 4.Pregnant or lactating women.
* 5.History of traumatic brain injury or neurosurgery.
* 6.Severe bradycardia (heart rate less than 40 beats per minute), sick sinus syndrome or second-to-third degree atrioventricular block.
* 7.Severe hepatic or renal dysfunction.

Primary outcomes:
measure: The incidence of postoperative delirium.
timeFrame: postoperative 5 day.
Secondary outcomes:
Other outcomes:
Locations:
city: Beijing
country: China
facility: Beijing Tian Tan Hospital, Capital Medical University
state: Beijing
Study officials:
affiliation: Beijing Tian Tan Hospital
name: Yuming Peng, MD,Ph.D
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT03320434: Study Evaluating the Efficacy and Safety of PRT-2761 for the Treatment of Acute and Chronic Allergic Conjunctivitis
Official title: A Single-Center, Randomized, Double-Masked, Vehicle and Active-Controlled, Dose-Ranging Phase 2 Study Evaluating the Efficacy and Safety of PRT-2761 for the Treatment of Acute and Chronic Allergic Conjunctivitis Using the Conjunctival Allergen Challenge Model (Ora-CAC®)
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE2
Conditions: Allergic Conjunctivitis
Lead sponsor: ORA, Inc.
Sponsor class: INDUSTRY
First posted: 2017-10-25
Enrollment: 120
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: To evaluate the efficacy and safety of two concentrations of PRT-2761 as a topical ophthalmic solution for the treatment of the signs and symptoms of acute and chronic allergic conjunctivitis.


Eligibility criteria: Inclusion Criteria:

* be at least 18 years old
* be willing and able to avoid all disallowed medications and contact lenses
* must have a pregnancy test if of childbearing potential
* must be able to read an eye chart from 10 feet away

Exclusion Criteria:

* must not have any allergies to the study medications
* must not have any ocular or non ocular condition that investigator feels will interfere with study parameters
* must not have used an investigational drug or device in the past 30 days or concurrently enrolled in another investigational trial

Primary outcomes:
measure: Ocular Itching at 5, 7, and 10 Minutes Post CAC on Day 1
timeFrame: post CAC exposure at 5, 7, and 10 minutes post CAC on Day 1
measure: Ocular Itching at 5, 7, and 10 Minutes Post CAC on Day 15
timeFrame: post CAC exposure at 5, 7, and 10 minutes post CAC on Day 15
measure: Conjunctival Redness at 7, 15, and 20 Minutes Post CAC on Day 1
timeFrame: post CAC exposure at 7, 15, and 20 minutes post-CAC on Day 1.
measure: Conjunctival Redness at 7, 15, and 20 Minutes Post CAC on Day 15
timeFrame: post CAC exposure at 7, 15, and 20 minutes post-CAC on Day 15.
Secondary outcomes:
Other outcomes:
Locations:
city: Andover
country: United States
facility: Andover Eye Associates
state: Massachusetts
Study officials:
References:
Clinical trial NCT00730834: Customized Acoustic Stimulation for Long Term Medical Benefit for the Relief of Tinnitus and Hyperacusis
Official title: Phase 4 Study of Use of a Customized Acoustic Stimulus to Reduce the Disturbing Symptoms of Tinnitus and Hyperacusis
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: PHASE4
Conditions: Tinnitus
Hyperacusis
Keywords: tinnitus
ringing in the ears
buzzing
static
hyperacusis
loudness discomfort
Clinically
significant
discomfort
Lead sponsor: Neuromonics, Inc.
Sponsor class: INDUSTRY
First posted: 2008-08-08
Enrollment: 53
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: NON_RANDOMIZED
Intervention model: SINGLE_GROUP
Primary purpose: TREATMENT

Brief summary: Neuromonics TInnitus Treatment CALM study is a multi site study of 100 adult subjects with clinically significant disturbing tinnitus to evaluate outcome measures using the FDA cleared Neuromonics treatment after 6, 12, 24 and 36 months. Patients must be meet certain inclusion criteria and they are also required to pay for the all costs of the treatment. Subjects will be provided a modest participation fee at 6, 12, 24 and 36 months upon completion of patient questionnaires (subjects must have access to a computer and internet in order to complete on line questionnaires).


Eligibility criteria: Inclusion Criteria:

* 18 years of age,
* TRQ of at least 17 or above,
* Able to pay for the treatment,
* Not using any other treatment for tinnitus,
* Access to computer and internet,
* Compliant patient

Exclusion Criteria:

* Hearing PTA \> 50 dB, score on HADS of greater than 11 on the anxiety and depression scale,
* Not willing to follow the protocol

Primary outcomes:
measure: Pre and post treatment scores on Tinnitus reaction questionnaire
timeFrame: 6, 12, 24, 36 months
Secondary outcomes:
measure: Tinnitus Handicap Inventory, Hospital Anxiety and Depression Scale,
timeFrame: 6, 12, 24, 36 months
Other outcomes:
Locations:
city: Sarasota
country: United States
facility: Silverstein Ear Institute
state: Florida
Study officials:
References:
Clinical trial NCT00585234: Tools for the Objective Clinical Assessment of Pediatric Spinal Deformity
Official title: Tools for Objective Clinical Assessment of Pediatric Spinal Deformity and the Results of Surgical Intervention--Simultaneous Measurement of Sagittal and Coronal Balance and Symmetry With Digital Photography.
Study type: OBSERVATIONAL
Overall status: WITHDRAWN
Conditions: Thoracic Insufficiency Syndrome
TIS
Lead sponsor: University of Utah
Sponsor class: OTHER
First posted: 2008-01-03
Enrollment: 0
Sex: ALL
Minimum age (years): 1
Maximum age (years): 18
Standard ages: CHILD
ADULT
Accepts healthy volunteers: yes
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Primary Care Center

Brief summary: This project seeks to develop a standardized technique for simultaneous capturing bi-planar images of patients against a standard background with a grid that can be used later for the quantitative determination of global balance and thoracic symmetry.

We hypothesize that patients who are successfully managed with surgery will demonstrate an improvement in global balance and thoracic symmetry that can be accurately measured. This measurement station will be specifically developed to provide a standardized, reproducible means to compare clinical assessments of surgical and non-surgical outcomes, and establish normative data for comparison. This standardized tool can be established at multiple centers for use in multicenter trials.


Eligibility criteria: Inclusion Criteria:

* Male and female participants from 1- skeletal maturity

Exclusion Criteria:

* no specific disease related exclusion criteria

Primary outcomes:
measure: Improvement in overall global balance following surgical intervention
timeFrame: Dec 2005-Dec 2008
Secondary outcomes:
measure: Improvement in overall global balance
timeFrame: Dec 2005-Dec 2008
Other outcomes:
Locations:
city: Salt Lake City
country: United States
facility: University of Utah
state: Utah
Study officials:
affiliation: University of Utah
name: John T Smith, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT03424434: Underreporting of Occupational Blood Exposure (OBE) Among Medical Staff at an University Hospital Center (UHC) in 2017 (OBE PRACTITIONERS UHC 2017)
Official title: Underreporting of Occupational Blood Exposure (OBE) Among Medical Staff at an University Hospital Center (UHC) in 2017
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Health Professional
Keywords: Occupational blood exposure
underreporting
medical
hospital
Lead sponsor: Hospices Civils de Lyon
Sponsor class: OTHER
First posted: 2018-02-07
Enrollment: 1493
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: OTHER
Time perspective: CROSS_SECTIONAL
Sampling method: NON_PROBABILITY_SAMPLE
Study population: University Hospital Center (UHC) Medical staff

Brief summary: Regarding 30 to 50% of occupational blood exposure (OBE) are underreporting among health professionals, it's to highlight that the part of medical professionals in OBE reporting is among the lowest (1996 to 2016). The current study is aiming to evaluate the underreporting of this specific occupational accident among medical staff for the year 2017. The investigators are supposing this is declining and the part of OBE reporting is better than before. So the current situation concerning OBE underreporting for medical staff in an University Hospital Center (UHC), 20 years after the first study, is our main purpose.


Eligibility criteria: Inclusion Criteria:

* Any medical or surgical health professional
* practitioner and resident
* working in an UHC
* without distinction of medical or surgical specialty
* having a professional mailbox

Exclusion Criteria:

* All paramedical health professionals (example: nurses) and pharmacists
* Any medical or surgical health professional working full-time outside an UHC
* Any medical or surgical health professional with exclusive liberal activity outside an UHC
* Administrative and technical staff of an UHC

Primary outcomes:
measure: Evaluation of underreporting occupational blood exposure (OBE) among the medical staff at an University Hospital Center (UHC) for the year 2017
timeFrame: 1 day
Secondary outcomes:
measure: The occurrence circumstances of OBE
timeFrame: 1 day
measure: The part of each factor, related to the professional activity and to the OBE itself, in the OBE reporting.
timeFrame: 1 day
measure: Involvement of behaviors of underreporting medical professionals
timeFrame: 1 day
measure: Practitioners knowledges about the specific infectious risk of OBE
timeFrame: 1 day
Other outcomes:
Locations:
city: Clermont-Ferrand
country: France
facility: CHU Clermont-Ferrand
city: La Tronche
country: France
facility: CHU Grenoble Alpes
city: Pierre-Bénite
country: France
facility: Groupement Hospitalier Sud
city: Saint-Étienne
country: France
facility: CHU de Saint-Etienne
Study officials:
References:
Clinical trial NCT01763034: Limb Ischemic Preconditioning for Prevention of Contrast Media Induced Nephropathy in Diabetic Kidney Patient
Official title: Limb Ischemic Preconditioning for Prevention of Contrast Media Induced Nephropathy in Diabetic Kidney Patient
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Serum Cystatin C Before and After Coronary Angiogram
Serum Creatinine Before and After Coronary Angiogram
Lead sponsor: Ramathibodi Hospital
Sponsor class: OTHER
First posted: 2013-01-08
Enrollment: 200
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: SINGLE_GROUP
Primary purpose: PREVENTION

Brief summary: Contrast media induced nephropathy (CIN) is considered to be a serious complication in patient who underwent coronary angiogram (CAG). The pathogenesis of CIN does not well understood. The probable one is the contrast media makes the afferent vessel in glomeruli constrict and results in renal shut down. Limb ischemic preconditioning, a procedure that makes muscles become ischemic and adapt themselves to produce some cytokines for signaling the vessel more dilated. After the reperfusion, these cytokines are getting back to systemic circulation and effect the afferent vessel in glomeruli to become more dilated and prevent CIN.


Eligibility criteria: Inclusion Criteria:

* Documented diabetic kidney disease
* Elective coronary angiogram
* Glomerular filtration rate \< 60 ml/min by Cockroft-Gault or Modification of Diet in Renal Disease or CKD-EPI

Exclusion Criteria:

* Refuse or reject to inform consented
* Hemodynamic compromise (Heart failure, need for intraaortic balloon pump)
* Expose to drug or chemical substances potentially to be a nephrotoxic agent with in 1 mo (Not include preexisting Angiotensin converting enzyme inhibitor or Angiotensin receptor blocker with stable serum creatinine)
* Documented or suspected of peripheral arterial disease, upper or lower limb
* Bleeding diathesis
* Contraindicated for coronary angiogram
* currently on renal replacement therapy

Primary outcomes:
measure: kidney injury before and after coronary angiogram.
timeFrame: 1 year
Secondary outcomes:
Other outcomes:
Locations:
city: Bangkok
country: Thailand
facility: Ramathibodi Hospital
Study officials:
References:
Clinical trial NCT03663634: Supplementing Intracytoplasmic Sperm Injection Handling Medium With Cytochalasin B
Official title: Cytochalasin B Supplementation to ICSI Handling Medium
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Infertility
Lead sponsor: Ibn Sina Hospital
Sponsor class: OTHER_GOV
Collaborators: name: Banoon IVF Center
First posted: 2018-09-10
Enrollment: 987
Sex: FEMALE
Minimum age (years): 18
Maximum age (years): 40
Standard ages: ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: PREVENTION

Brief summary: Vienna Consensus has identified 10% damage rate after ICSI as a competency value. Despite the highest quality embryologists doing ICSI, degeneration sometimes occurs due to oocyte factors such as the fragile membrane, etc. Cytochalasin B serves to facilitate spindle or pronuclear transfer procedures helping to reduce the damage rate with no harm reported. Using Cytochalasin B during ICSI could serve to rescue some oocytes from the degeneration allowing for more chances of viable zygotes,


Eligibility criteria: Inclusion Criteria:

* All ICSI candidates patients

Exclusion Criteria:

* No exclusion

Primary outcomes:
measure: oocyte survival rate
timeFrame: 6 days of culture
Secondary outcomes:
measure: fertilization rate
timeFrame: 6 days of culture
measure: blastocyst formation rate
timeFrame: 6 days of culture
measure: embryo utilization rate
timeFrame: 6 days of culture
measure: clinical pregnancy rate
timeFrame: three months
measure: ongoing pregnancy rate
timeFrame: four months
Other outcomes:
Locations:
city: Sohag
country: Egypt
facility: IbnSina IVF Center
Study officials:
References: