louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT03033654: Two Consecutive Sunscreen Applications Optimize Sun Protection
Official title: Two Consecutive Sunscreen Applications Optimize Sun Protection
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Sun Protection
Lead sponsor: Bispebjerg Hospital
Sponsor class: OTHER
First posted: 2017-01-27
Enrollment: 31
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: PREVENTION

Brief summary: The investigators aim to investigate how much two consecutive applications of sunscreen before sun exposure can increase the quantities of sunscreen applied and decrease the skin area left without sunscreen compared to a single application. Volunteers wearing swimwear applied sunscreen in a laboratory environment twice and had pictures taken in black light before and after. As sunscreens absorb black light the darkness of the skin increased with increasing amounts of sunscreen applied. The investigators conducted a standard curve establishing a link between picture darkness and applied sunscreen quantity. Participants were asked to apply sunscreen the way they would normally do but two consecutive times. No other advice was given. The level of protection was determined by picture analysis as measurements of darkness of selected skin sites as well as the percentages of skin area left without sunscreen in different body regions and in total.


Eligibility criteria: Inclusion Criteria:

* Healthy Caucasians between older than 18

Exclusion Criteria:

* Suffering from a skin disease, were allergic to the content in sunscreen, were pregnant or breastfeeding

Primary outcomes:
measure: Sun protection
timeFrame: The day of intervention. Sun protection will be assessed right after sunscreen application.
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
References:
Clinical trial NCT01133054: Physiologic Evaluation of Anomalous Right Coronary Artery Stenosis
Official title: Physiologic Evaluation of Anomalous Right Coronary Artery Stenosis
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE4
Conditions: Coronary Vessel Anomalies
Keywords: Coronary Vessel Anomalies
Lead sponsor: Seoul National University Hospital
Sponsor class: OTHER
First posted: 2010-05-28
Enrollment: 36
Sex: ALL
Minimum age (years): 20
Maximum age (years): 85
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NON_RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The anomalous origin of right coronary artery (RCA) is a rare coronary anomaly. Recently, the detection of this anomaly has been more frequent as the use of cardiac multidetector computed tomography has become more popular. It can cause myocardial ischemia, syncope and sudden cardiac death. Surgical repair is generally recommended for symptomatic patients. However, there is controversy concerning the proper evaluation and treatment strategy for patients without documented myocardial ischemia.

The stenotic lesion of anomalous origin of RCA will be assessed by fractional flow reserve (FFR).


Eligibility criteria: Inclusion Criteria:

* patients diagnosed as anomalous origin of right coronary artery from left coronary cusp

Exclusion Criteria:

* poor compliance
* need for percutaneous coronary intervention to significant coronary lesion
* failure of FFR for anomalous origin of right coronary artery

Primary outcomes:
measure: cardiac death
timeFrame: 12 months
Secondary outcomes:
Other outcomes:
Locations:
city: Seoul
country: Korea, Republic of
facility: Seoul National University Hospital
Study officials:
affiliation: Seoul National University Hospital
name: Bon-Kwon KOO, M.D.
role: STUDY_CHAIR
References:
Clinical trial NCT01285154: Modified Triple Osteotomy for Acetabular Dysplasia
Official title: Modified Triple Osteotomy for Acetabular Dysplasia - A Modified Technique for Better Femoral Head Medialization and Coverage
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Sharp Angle
Center Edge Angle
Femoral Head Extrusion Index
Center Head Distance Discrepancy
Keywords: Hip dysplasia
Triple Osteotomy
Femoral Head Coverage
Femoral Head Medialization
Lead sponsor: National Taiwan University Hospital
Sponsor class: OTHER
First posted: 2011-01-27
Enrollment: 2
Sex: ALL
Minimum age (years): 6
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: CASE_ONLY
Time perspective: RETROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: Young adults and adolescents underwent triple innominate osteotomy for symptomatic acetabular dysplasia in our institution

Brief summary: Steel triple innominate osteotomy was designed for dysplastic hip in adolescents and young adults with three incisions to increase the coverage; however the amount of correction remained questionable due to ligamentous attachments that hinder the rotation. The investigators modified the technique with two anterior incisions and ramus cuts close to inferior acetabulum. The purpose of this study is to compare these two techniques in femoral head coverage


Eligibility criteria: Inclusion Criteria:

1. Symptomatic acetabular dysplasia in adolescent or young adult
2. Closed triradiate cartilage
3. Minor coxarthrosis with Tonnis grades at 1 or 2

Exclusion Criteria:

1. High subluxation or complete dislocation of the hip joint
2. Severe osteoarthrosis
3. Combined with proximal femoral osteotomy that changed the femoral neck shaft angle (such as varus or valgus osteotomy)

Primary outcomes:
Secondary outcomes:
Other outcomes:
Locations:
city: Taipei
country: Taiwan
facility: National Taiwan University Hospital
Study officials:
affiliation: National Taiwan University Hospital, Department of Orthopaedic Surgery
name: Yi-Chen Li, M.D.
role: STUDY_CHAIR
References:
Clinical trial NCT02266654: Early Goal Directed Therapy in Sepsis by Emergency Medical Services
Official title: Early Goal Directed Therapy in Sepsis by EMS
Study type: INTERVENTIONAL
Overall status: WITHDRAWN
Phase: NA
Conditions: Sepsis
Keywords: Emergency Medical Services
Lactic Acid
Sepsis
Lead sponsor: Massachusetts General Hospital
Sponsor class: OTHER
Collaborators: name: Pro EMS
name: Mount Auburn Hospital
First posted: 2014-10-17
Enrollment: 0
Sex: ALL
Minimum age (years): 17
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NON_RANDOMIZED
Intervention model: SINGLE_GROUP
Primary purpose: TREATMENT

Brief summary: The goal is to evaluate the best way for paramedics and hospitals to work together to treat septic patients as quickly as possible.

The investigators think that the best thing to do for septic patients is to identify and treat them as early as possible. This research will test this. The investigators think that if paramedics identify septic patients and begin treatment with fluids in the ambulance, then the patient will do better in the long run. The paramedic will also tell the hospital that a septic patient will be there soon. The caregivers can prepare and be ready to provide care as soon as the patient arrives. With this research, the investigators would like to see if these steps help patient outcomes.


Eligibility criteria: Inclusion Criteria:

* Older than 17 years of age
* Suspected to having an infection
* Meets 2 of 3 systemic inflammatory response criteria: heart rate \> 90 beats per minute, respiratory rate \>20 breaths per minute, temperature \>38°C or \<36°C

Exclusion Criteria:

* Transfer from another hospital
* Patients, coming from a rehabilitation/nursing facility where antibiotics were given prior to transfer
* Pregnant patients
* Prisoners.

Primary outcomes:
measure: Time to antibiotics
timeFrame: During the Emergency Department stay (expected to be 5 hours)
Secondary outcomes:
measure: Mortality
timeFrame: Participants will be followed for the duration of hospital stay, an expected average of 1 week
measure: Need for pressors in the Emergency Department
timeFrame: During the Emergency Department stay (expected to be 5 hours)
measure: Admitted to the Intensive Care Unit from the Emergency Department
timeFrame: During the Emergency Department stay (expected to be 5 hours)
Other outcomes:
Locations:
city: Cambridge
country: United States
facility: Mount Auburn Hospital
state: Massachusetts
Study officials:
affiliation: Massachusetts General Hospital
name: Michael Filbin, MD
role: PRINCIPAL_INVESTIGATOR
affiliation: Mount Auburn Hospital
name: William Porcaro, MD, MPH
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT00395954: Amount of Lactose Causing Symptoms in Lactose Intolerant People
Official title: A Study to Determine the Threshold of Lactose Ingestion That Provokes Symptoms in Lactose Intolerant People.
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Lactose Intolerance
Keywords: Lactose Intolerance
Lactose
Threshold
Lead sponsor: University Hospitals, Leicester
Sponsor class: OTHER
First posted: 2006-11-06
Enrollment: 48
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Time perspective: PROSPECTIVE

Brief summary: The hypothesis underlying this study is that failure to recognise the role of lactose intolerance among patients has led to inappropriate dietary advice and treatment with drugs that contain lactose as a filler. These failures exacerbate symptoms and lead to the unnecessary use of immune suppressant drugs.

This study will identify the threshold at which symptoms of lactose intolerance develop, to provide appropriate advice and treatment in the management of patients.


Eligibility criteria: Inclusion Criteria:

* Confirmed lactose intolerance demonstrated with a lactose intolerance test.
* Adherence to a lactose free diet for at least four days before the start of the study.

Exclusion Criteria:

* Failure to adhere to a lactose free diet.
* People who are on lactose containing medications.
* Pregnancy.
* Unwillingness to comply with study outline.

Primary outcomes:
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
affiliation: University Hospitals, Leicester
name: John F Mayberry, DSc MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT00939354: Asthma in the Elderly: The Role of Exhaled Nitric Oxide Measurements
Official title: Asthma in the Elderly: The Role of Exhaled Nitric Oxide Measurements
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Asthma
Keywords: Asthma in subjects over the age of 65
Lead sponsor: Rohr and Columbo Asthma, Allergy and Immunology Specialists, P.C.
Sponsor class: OTHER
First posted: 2009-07-15
Enrollment: 30
Sex: ALL
Minimum age (years): 65
Standard ages: OLDER_ADULT
Accepts healthy volunteers: no
Observational model: CASE_ONLY
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Subjects with asthma over the age of 65 who are currently followed in our practice

Brief summary: This study will investigate the importance of exhaled nitric oxide measurements in subjects with asthma age 65 and older. This group of patients has been ignored in most previous asthma studies.


Eligibility criteria: Inclusion Criteria:

* Subjects with asthma over the age of 65 followed in our practice, non-smokers and able to give informed consent to participate in the study

Exclusion Criteria:

* Smokers, subjects of diminished mental capacity

Primary outcomes:
measure: Exhaled Nitric Oxide (FENO) levels and their changes with time
timeFrame: One year
Secondary outcomes:
measure: Correlations of FENO with subjects' demographics, comorbidities, treatment, symptoms, or spiromentric values
timeFrame: One year
Other outcomes:
Locations:
Study officials:
affiliation: Rohr and Columbo Associates
name: Albert S Rohr, M.D.
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT01747954: Effects of Physiotherapy in Hemodynamics and Childrens Respiratory Mechanics
Official title: Respiratory Mechanics and Hemodynamics in Children With Respiratory Failure: Comparison of Two Techniques of Respiratory Physiotherapy
Study type: INTERVENTIONAL
Overall status: TERMINATED
Phase: NA
Conditions: Respiratory Insufficiency
Children
Keywords: Respiratory Insufficiency
Physiotherapy Techniques
Respiratory Mechanics
Lead sponsor: Federal University of Uberlandia
Sponsor class: OTHER
First posted: 2012-12-12
Enrollment: 12
Sex: ALL
Minimum age (years): 1
Maximum age (years): 60
Standard ages: CHILD
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: SINGLE_GROUP
Primary purpose: TREATMENT

Brief summary: The hypothesis of this study is that respiratory physiotherapy can promote improvement in respiratory mechanics in children with respiratory failure and the bag squeezing maneuver is more effective in improving respiratory mechanics in childrens and does not alter the hemodynamic proved safe


Eligibility criteria: Inclusion Criteria:

* children aged between one and 60 months
* diagnosed with respiratory failure
* undergoing mechanical ventilation

Exclusion Criteria:

* had traumatic brain injury
* severe thrombocytopenia (\<20,000 pl/mm³)
* hypovolemia and cyanogenic congenital heart defects
* pneumothorax, hemothorax and/or pleural effusion without previous drainage

Primary outcomes:
measure: Effects of Bag Squeezing and vibrocompression chest in hemodynamic, resistance and respiratory system compliance
timeFrame: one hundred twenty minutes
Secondary outcomes:
measure: comparing all variables between the two groups
timeFrame: one hundred twenty minutes
Other outcomes:
Locations:
Study officials:
affiliation: Federal University of Uberlandia
name: Letícia Martins
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT05641454: The Effect of a Peat and Apple Extract on Muscle ATP and Exercise Performance
Official title: The Effect of a Peat and Apple Extract on Muscle ATP and Exercise Performance
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Caffeine and Endurance Performance
Lead sponsor: University of Exeter
Sponsor class: OTHER
Collaborators: name: VDF FutureCeuticals Inc.
First posted: 2022-12-07
Enrollment: 10
Sex: MALE
Minimum age (years): 18
Maximum age (years): 40
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: CROSSOVER
Primary purpose: BASIC_SCIENCE

Brief summary: A study to test the hypothesis that a combined peat and apple extract will increase blood and muscle ATP, which will increase cycling performance


Eligibility criteria: Inclusion Criteria:

* Age 18 - 40
* Healthy
* Recreationally active (i.e. Participants will be deemed as too trained if they are defined as participating in structured resistance exercise 3 or more times per week for \>6 months or participating in structured endurance exercise for \>6h per week for \>6 months. Participants will be defined as too sedentary if they do not exceed the governments guidelines of 150 / 75 min per week of light / heavy exercise.)

Exclusion Criteria:

* Allergy to Lidocaine
* Any diagnosed metabolic health condition
* Pregnant
* Non-habitual caffeine intake
* Smoker
* Diagnosed Cardiovascular disease
* Beta-Blockers
* Recent history of musculoskeletal injury

Primary outcomes:
measure: Muscle ATP concentration
timeFrame: 4 hours
Secondary outcomes:
measure: Total work performed during exercise
timeFrame: 2 hours
measure: Blood ATP concentration
timeFrame: 4 hours
measure: Substrate oxidation
timeFrame: 1 hour
measure: Blood glucose concentration
timeFrame: 4 hours
measure: Blood lactate concentration
timeFrame: 4 hours
measure: Muscle glycogen
timeFrame: 4 hours
measure: Muscle ADP concentration
timeFrame: 4 hours (mmol/kg dry weight)
measure: Muscle ATP concentration
timeFrame: 4 hours (mmol/kg dry weight)
measure: Muscle creatine concentration
timeFrame: 4 hours (mmol/kg dry weight)
measure: Muscle phosphocreatine concentration
timeFrame: 4 hours (mmol/kg dry weight)
Other outcomes:
Locations:
city: Exeter
country: United Kingdom
facility: University of Exeter
state: Devon
Study officials:
References:
Clinical trial NCT02949154: Elevated LDH Serum Levels and FDG-PET in Metastatic Melanoma Patients
Official title: Elevated LDH Serum Levels and FDG-PET in Metastatic Melanoma Patients
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Melanoma
Lead sponsor: University Medical Center Groningen
Sponsor class: OTHER
First posted: 2016-10-31
Enrollment: 65
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: RETROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Patients with metastatic melanoma

Brief summary: A retrospective study investigating the relationship between FDG-PET uptake and LDH levels.

Detailed description: Patient characteristics, tumour characteristics including the BRAF mutation status and baseline serum S100B and LDH levels of each patient will be retrospectively determined from the electronical patient file. In each patient, tumour burden and 18F-FDG uptake of the tumour lesions will be measured using multiple standard quantification parameters of the baseline 18F-FDG-PET scan. Tumour burden will also be measured on the baseline contrast enhanced CT scan. The correlation of each FDG-PET parameter with baseline LDH and S100B levels, respectively, will be analyzed using univariate and multivariate regression analysis.

Eligibility criteria: Inclusion Criteria:

- All patients \>18 years with histologically proven metastatic melanoma (American Joint Committee on Cancer \[AJCC\] stage IV melanoma) treated in the UMCG between May 2014 and December 2015.

Exclusion Criteria:

* participation in interventional studies
* missing baseline 18F-FDG PET scan and/or baseline contrast enhanced CT scan
* missing baseline serum LDH level
* missing BRAF mutation status, concurrent malignancies or a history of previous malignancies.

Primary outcomes:
measure: Independent correlation between baseline serum LDH level and 18F-FDG uptake of tumour lesions
timeFrame: 3 months
Secondary outcomes:
measure: Correlation between baseline serum LDH level and tumour 18F-FDG uptake in subgroups separated by metastasis site
timeFrame: 3 months
measure: Correlation between baseline serum S100B level and tumour 18F-FDG uptake
timeFrame: 3 months
measure: Difference between tumour burden as measured on CT scan and on 18F-FDG-PET
timeFrame: 3 months
measure: Difference between tumour volume as determined by manual measurement or semiautomatic measurement
timeFrame: 3 months
measure: Correlation of baseline serum LDH level with tumour volume as measured on CT scan and as measured on 18F-FDG-PET scan
timeFrame: 3 months
Other outcomes:
Locations:
city: Groningen
country: Netherlands
facility: University Medical Center Groningen
Study officials:
affiliation: University Medical Center Groningen
name: M. Jalving, MD, PhD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT01104454: Placenta and Cord Blood Analyses
Official title: Placenta and Cord Blood Analyses
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Healthy
Keywords: healthy pregnant women
Lead sponsor: Arkansas Children's Hospital Research Institute
Sponsor class: OTHER
First posted: 2010-04-15
Enrollment: 60
Sex: FEMALE
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: COHORT
Time perspective: CROSS_SECTIONAL
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Pregnant women who are at least 7 months pregnant

Brief summary: The purpose of this study is to standardize methods in collecting and processing placenta, umbilical cord and cord blood samples. Samples will be used to determine potential differences between normal weight, overweight and obese individuals.


Eligibility criteria: Inclusion Criteria:

* at least 7 months pregnant
* 18 years of age or older

Exclusion Criteria:

* underweight (BMI\<18.5)

Primary outcomes:
measure: Placenta, cord blood and umbilical analyses
timeFrame: at delivery
Secondary outcomes:
Other outcomes:
Locations:
city: Little Rock
country: United States
facility: Arkansas Children's Nutrition Center
state: Arkansas
Study officials:
affiliation: University of Arkansas
name: Aline Andres, Ph.D.
role: PRINCIPAL_INVESTIGATOR
References:
citation: Saben J, Zhong Y, Gomez-Acevedo H, Thakali KM, Borengasser SJ, Andres A, Shankar K. Early growth response protein-1 mediates lipotoxicity-associated placental inflammation: role in maternal obesity. Am J Physiol Endocrinol Metab. 2013 Jul 1;305(1):E1-14. doi: 10.1152/ajpendo.00076.2013. Epub 2013 Apr 30.
Clinical trial NCT02009254: The Effect of Mashed Potato Composition on Food Intake, Satiety and Blood Glucose
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Obesity
Overweight
Diabetes
Metabolic Syndrome
Lead sponsor: University of Toronto
Sponsor class: OTHER
First posted: 2013-12-11
Sex: MALE
Minimum age (years): 18
Maximum age (years): 35
Standard ages: ADULT
Primary purpose: PREVENTION

Brief summary: Potato is one of the world's most popular foods and is widely accepted as a staple food. The objective of this study is to determine the effect of consuming instant mashed potatoes with and without fat on glycemic response, subjective appetite and food intake. It is hypothesized that mashed potato with added fat (as it is usually consumed) will result in lower glycaemic response and subjective appetite, and reduced subsequent food intake.


Eligibility criteria: Inclusion Criteria:

* •Healthy men with a body mass index (kg/m2) of 20-24.9

Exclusion Criteria:

* •smocking, medication, breakfast skipping, restrained eating

Primary outcomes:
measure: blood glucose
timeFrame: 120 min
Secondary outcomes:
measure: food intake
timeFrame: 120 min
Other outcomes:
measure: subjective appetite
timeFrame: 120 min
Locations:
Study officials:
References: