Clinical trial NCT05386953: Intraoperative Normal Saline Administration and Acute Kidney Injury in Patients Undergoing Liver Transplantation
Official title: Intraoperative Normal Saline Administration and Acute Kidney Injury in Patients Undergoing Liver Transplantation: a Retrospective Cohort Study
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: End Stage Liver DIsease
Liver Transplant; Complications
Liver Cirrhosis
Lead sponsor: Seoul National University Hospital
Sponsor class: OTHER
First posted: 2022-05-24
Enrollment: 1440
Sex: ALL
Minimum age (years): 20
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: RETROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Patients received liver transplantation surgery in a single tertiary care university hospital

Brief summary: The investigators attempted to investigate the association of the type of crystalloid administered during liver transplantation with postoperative clinical outcomes. The investigators hypothesized that the greater amount of normal saline or half-saline administered during liver transplantation might be associated with the increased risk of acute kidney injury compared to the balanced crystalloids.

Detailed description: Liver transplantation requires a long operation time and is often associated with a significant amount of surgical bleeding. It is common for the anesthesiologist to infuse large amounts of fluid or blood products due to bleeding, hemodynamic instability, or ascites drainage. Therefore, in the anesthesia for liver transplantation, optimal management of fluid administration is necessary and the choice of the type of crystalloid may affect the prognosis or the incidence of postoperative complications of patients.

The investigators attempted to investigate the association of the type of crystalloid administered during liver transplantation with postoperative clinical outcomes. The investigators hypothesized that the greater amount of normal saline or half-saline administered during liver transplantation might be associated with the increased risk of acute kidney injury compared to the balanced crystalloids.

Eligibility criteria: Inclusion Criteria:

* Consecutive patients who underwent living or deceased donor liver transplantation at our tertiary care university hospital between 2004 and 2018

Exclusion Criteria:

* patients with baseline renal dysfunction of hepatorenal syndrome or chronic kidney disease
* missing preoperative serum creatinine value
* missing other baseline or outcome variables
* patients who received retransplantation

Primary outcomes:
measure: Acute kidney injury
timeFrame: the first 7 postoperative days
Secondary outcomes:
measure: Incidence of postoperative hemodialysis
timeFrame: the first month after admission
measure: Early allograft dysfunction
timeFrame: the first 7 postoperative days
measure: In-hospital mortality
timeFrame: the first month after admission
measure: One-year mortality
timeFrame: one year after transplantation
measure: Length of intensive care unit stay
timeFrame: the first month after admission
measure: Length of hospital stay
timeFrame: the first month after admission
Other outcomes:
Locations:
city: Seoul
country: Korea, Republic of
facility: Seoul National University Hospital
Study officials:
affiliation: Department of Anaesthesiology and Pain Medicine, Seoul National University Hospital
name: Won Ho Kim, MD, PhD
role: STUDY_CHAIR
References: