Clinical trial NCT05987436: Effect of Aerobic Exercise in Patients With Essential Hypertension
Official title: Effects of Supervised Versus Unsupervised Aerobic Exercise Training on Weight Loss, Functional Capacity, Quality of Life and Depression Level in Patients With Essential Hypertension
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Aerobic Exercise
Essential Hypertension
Keywords: supervised aerobic exercise
functional capacity
quality of life
depression level
essential hypertension
Lead sponsor: TC Erciyes University
Sponsor class: OTHER
First posted: 2023-08-14
Enrollment: 138
Sex: ALL
Minimum age (years): 18
Maximum age (years): 75
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Patients with Essential Hypertension

Brief summary: The goal of this observational study is to evaluate the effects of a supervised aerobic exercise training program on weight loss, functional capacity, quality of life (QoL), and depression levels in patients with essential hypertension.

Detailed description: Patients who chose the treatment type according to personal preferences were divided into two groups: Group 1(n:91) exercised for six weeks, five sessions per week under the supervision of a medical doctor in the aerobic exercise laboratory, and group 2(n:47) was advised to maintain dietary habits and physical activity levels. Body weight, serum lipid levels, functional capacity, QoL, and depression level of all the participants were evaluated at baseline and 6 weeks later.

Eligibility criteria: Inclusion Criteria:

* Over 18 years of age,
* Absence of concomitant other metabolic and cardiovascular diseases.

Exclusion Criteria:

* Having suffered an event of ischaemic heart disease (\<6 months),
* Secondary hypertension,
* Hypertrophic obstructive cardiomyopathy,
* Congestive heart failure,
* Uncontrolled cardiac arrhythmia,
* Thyroid dysfunction,
* Diabetes mellitus,
* Symptomatic peripheral arterial occlusive disease,
* Aortic insufficiency or stenosis,
* Pulmonary or heart disease with dyspnoea at small or moderate effort,
* An outbreak of orthopedic problems on hip, knee or ankles, such as arthroplasty, contracture or severe osteoarthritis,
* Using of antidepressant or anxiolytic drugs,
* Pregnancy,
* Cognitive disfunction.

Primary outcomes:
measure: Body weight
timeFrame: was measured at the pre-treatment period and the post-treatment 6th week for all the participants by the same physician.
measure: Blood samples
timeFrame: Twelve-hour fasting blood samples were collected between 6.00 am, and 10.00 am at baseline and week 6.
measure: The functional capacity
timeFrame: 6MWT was assessed in face-to-face interviews before and immediately after the treatment was completed.
measure: Quality of Life
timeFrame: SF36 was assessed in face-to-face interviews before and immediately after the treatment was completed.
measure: Depression level
timeFrame: BDI was assessed in face-to-face interviews before and immediately after the treatment was completed.
Secondary outcomes:
Other outcomes:
Locations:
city: Konya
country: Turkey
facility: Selcuk University Faculty of Medicine
Study officials:
References: