Clinical trial NCT04041154: Behavioral and Neural Representations of Subjective Effort Cost
Official title: Behavioral and Neural Representations of Subjective Effort Cost
Study type: INTERVENTIONAL
Overall status: RECRUITING
Phase: NA
Conditions: Fatigue
Lead sponsor: Hugo W. Moser Research Institute at Kennedy Krieger, Inc.
Sponsor class: OTHER
Collaborators: name: National Institute of Mental Health (NIMH)
First posted: 2019-08-01
Enrollment: 185
Sex: ALL
Minimum age (years): 18
Maximum age (years): 35
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: NON_RANDOMIZED
Intervention model: SINGLE_GROUP
Primary purpose: BASIC_SCIENCE

Brief summary: The goal of this proposal is to understand the common and distinct behavioral and neural representations of subjective effort valuation, and how these representations are influenced by fatigue and changes in motivation. It is hypothesized that the brain will use overlapping and distinct neural circuits to represent cognitive and physical effort value, and that fatigue and enhanced motivation will influence the subjective value of effort.

Detailed description: How effortful a task feels is an integral aspect of human decision-making that shapes motivation. If a task feels very effortful one may be unwilling to perform the work required, whereas if a task feels less effortful one may be more likely to persevere. Despite the importance of these perceptions for decision-making, the behavioral and neural mechanisms of subjective effort valuation are not well understood. Furthermore, the National Institutes of Mental Health (NIMH) Research Domain Criteria (RDoC) has identified "Effort Valuation / Willingness to Work" as a key subconstruct for understanding deficits in motivated performance in mental disorders. The goal of this proposal is to understand the mechanisms of subjective valuation of physical and cognitive effort, and the common and distinct systems that underlie these representations. To this end, a combination of experiments in healthy human participants, computational modeling of behavior, and functional magnetic resonance imaging (fMRI) will be used. Aim 1 will identify common and distinct physical and cognitive effort valuation mechanisms. Computational models will be used to characterize participants' subjective valuation of physical and cognitive effort, and to test if there are similarities in subjective preferences for these different types of effort. Model-based fMRI will be used to examine the common and distinct brain regions that encode the subjective valuation of physical and cognitive effort, and the network of brain regions that incorporate such preferences to motivate effortful engagement. Aim 2 will investigate the behavioral and neural mechanisms by which physical and cognitive fatigue effect effort valuation. Participants will be fatigued with sustained physical or cognitive exertion to examine how being in a fatigued state influences subjective valuation of physical and cognitive effort; and associated signals in the brain's valuation network. Aim 3 will explore how motivational state modulates decisions to exert physical and cognitive effort. Choices for physical and cognitive effort will be paired with motivational cues (i.e., cues that formerly predicted reward) in order to modulate participants' motivational state. This manipulation will allow for behavioral and neural dissociations between motivation and effort valuation in order to understand how these processes interact to give rise to motivated physical and cognitive engagement. In sum, the proposed studies will have a broad impact on the field of decision-making by dissecting the behavioral and neural mechanisms responsible for physical and cognitive effort valuation. In the long term, these studies may reveal novel behavioral and neural markers to aid in the study, classification, and treatment of amotivation.

Eligibility criteria: Inclusion Criteria:

* Right-handed
* Age between 18 and 35 years old - Male or female
* Any ethnicity

Exclusion Criteria:

Individuals with a history of any of the following will be excluded from the study:

* Neurological problems such as stroke, head injury, epilepsy, seizures, brain tumors, brain surgery, Parkinson's Disease (self- report)
* Diagnosed history of severe psychiatric disease such as depression, schizophrenia (self-report)
* Metal in the head or eyes
* If they are pregnant or suspect that you may be pregnant
* If they experience discomfort from the MRI scan, such as severe claustrophobia or excessive heating of tattoos

Primary outcomes:
measure: Mean of cognitive subjective effort parameters (from behavioral choice data)
timeFrame: 1 day
measure: Differences between cognitive subjective effort parameters before and after fatigue (from behavioral choice data)
timeFrame: 1 day
measure: Mean of physical subjective effort parameters (from behavioral choice data)
timeFrame: 1 days
measure: Differences between physical subjective effort parameters before and after fatigue (from behavioral choice data)
timeFrame: 1 day
measure: Difference between cognitive effort cost parameters between the low and high reward stimuli
timeFrame: 1 day
measure: Difference between physical effort cost parameters between the low and high reward stimuli
timeFrame: 1 day
measure: Regions of the brain encoding cognitive effort
timeFrame: 1 day
measure: Regions of the brain encoding physical effort
timeFrame: 1 day
measure: Regions of the brain encoding changes cognitive effort value following cognitive fatigue
timeFrame: 1 day
measure: Regions of the brain encoding changes physical effort value following physical fatigue
timeFrame: 1 day
measure: Regions of the brain encoding differences in cognitive effort value resulting from reward-induced changes in motivation
timeFrame: 1 day
measure: Regions of the brain encoding differences in physical effort value resulting from reward-induced changes in motivation
timeFrame: 1 day
Secondary outcomes:
Other outcomes:
Locations:
city: Baltimore
country: United States
facility: Kennedy Krieger Institute
state: Maryland
Study officials:
affiliation: Kennedy Krieger Institute and Johns Hopkins School of Medicine
name: Vikram S. Chib, PhD
role: PRINCIPAL_INVESTIGATOR
References: