Clinical trial NCT02938117: Impact of a Training Program on the Body Composition of Overweight and Obese Young Adults : Concentric Versus Eccentric Exercise
Official title: Impact of a Training Program on the Body Composition of Overweight and Obese Young Adults : Concentric Versus Eccentric Exercise
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Adults
BMI>35
Keywords: obesity
eccentric exercise
body composition
training program
Lead sponsor: University Hospital, Clermont-Ferrand
Sponsor class: OTHER
First posted: 2016-10-19
Enrollment: 30
Sex: ALL
Minimum age (years): 18
Maximum age (years): 35
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL

Brief summary: Nowadays, eccentric exercise can be realized in a dynamic way with an ergocycle wich permits eccentric (ECC) lower limbs contractions at a defined power output. With this type of ergometer, O2 consumption (VO2) in ECC is three fold lower than in concentric (CON) for the same power output. Consequently, ECC program could be used in chronic disorders with limited capacities, such as obesity.

The investigators hypothesis that an eccentric training program, as it will induce higher mechanical constraints, would improve body composition, especially by reducing fat mass. This effect could be explained by an increased rest energy expenditure and a better improvement in biological parameters (particularly lipid profile and insulin-resistance) after ECC training (versus CON training).

This study aims to compare the modification of fat mass after an ECC program versus a CON program at the same VO2. The secondary goal is to assess the physiological mechanisms involved in the modification of body composition

Detailed description: Thirty adults will be randomized into 2 groups: CON or EXC. The patients of ECC group will follow habituation sessions (2weeks) to avoid the secondary muscular effects of high intensity eccentric exercise. The training program will last 12 weeks for the two groups. Before and after, each subjects will participate to the following measurements: total and segmental body composition (DXA), aerobic capacities (maximal incremental exercise test, VO2max), muscular lower limbs strength (isometric end isokinetic dynamometer), rest energy expenditure (indirect calorimetry), biological parameters (lipid profile, insulin-resistance), physical activity (actimetry), food intakes and quality of life (questionnaires).

Eligibility criteria: Inclusion Criteria:

* - Adults
* Obese (BMI\>35)
* Inactive (\<10 METS/h/week)
* No other chronic disease (cardio pulmonary, osteo articulary or muscular diseases), no surgery during the last 3 months, no contraindication to physical activity

Exclusion Criteria:

* (BMI\<35)

Primary outcomes:
measure: change in total body fat mass (Dual X ray Absorptiometry)
timeFrame: before and after the 12 weeks training program
Secondary outcomes:
measure: aerobic capacities (VO2max)
timeFrame: before and after the 12 weeks training program
measure: isometric muscular lower limbs strength
timeFrame: before and after the 12 weeks training program
measure: isokinetic muscular lower limbs strength
timeFrame: before and after the 12 weeks training program
measure: rest energy expenditure (indirect calorimetry)
timeFrame: before and after the 12 weeks training program
measure: biological parameters (plasma lipid profile)
timeFrame: before and after the 12 weeks training program
measure: biological parameters (insulin-resistance)
timeFrame: before and after the 12 weeks training program
measure: physical activity
timeFrame: before and after the 12 weeks training program
measure: physical activity
timeFrame: before and after the 12 weeks training program
measure: food intakes
timeFrame: before and after the 12 weeks training program
measure: food intakes
timeFrame: before and after the 12 weeks training program
measure: quality of life (questionnaires)
timeFrame: before and after the 12 weeks training program
measure: segmental body composition
timeFrame: before and after the 12 weeks training program
Other outcomes:
Locations:
city: Clermont-Ferrand
country: France
facility: CHU Clermont-Ferrand
Study officials:
affiliation: University Hospital, Clermont-Ferrand
name: Valérie JULIAN
role: PRINCIPAL_INVESTIGATOR
References: