Clinical trial NCT03814317: Inhaled Treprostinil in Sarcoidosis Patients With Pulmonary Hypertension
Official title: An Open-Label Study of Inhaled Treprostinil in Sarcoidosis Patients With Pulmonary Hypertension and Interstitial Lung Disease (SAPPHIRE)
Study type: INTERVENTIONAL
Overall status: RECRUITING
Phase: PHASE2
Conditions: Sarcoidosis
Precapillary Pulmonary Hypertension
Interstitial Lung Disease
Keywords: right heart catheterization (RHC)
pulmonary vascular resistance (PVR)
mean pulmonary arterial pressure (mPAP)
pulmonary hypertension (PH)
Inhaled treprostinil
Sarcoidosis
Lead sponsor: University of Florida
Sponsor class: OTHER
Collaborators: name: United Therapeutics
First posted: 2019-01-24
Enrollment: 10
Sex: ALL
Minimum age (years): 18
Maximum age (years): 99
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Intervention model description: All subjects will initiate inhaled treprostinil at a dose of 3 breaths (18 mcg) four times daily. Study drug doses escalations (additional one breath four times daily) can occur every three days with a maximum dosing regimen of up to 12 breaths (72 mcg) four times daily, as clinically tolerated.
Primary purpose: TREATMENT

Brief summary: This study aims to evaluate the efficacy and safety of inhaled treprostinil in subjects with sarcoidosis-associated interstitial lung disease and pulmonary hypertension.

Detailed description: Pulmonary sarcoidosis-associated pulmonary hypertension is classified as WHO Group 5 pulmonary hypertension and may occur in anywhere from 5-20% of sarcoidosis patients. Inhaled treprostinil has shown clinical improvements in exercise capacity after 12 weeks of therapy in patients with WHO Group 1 pulmonary hypertension. More recently, there has been interest in using inhaled PAH-specific therapies for the treatment of pulmonary hypertension associated with interstitial lung disease.

The investigators believe that those patients with pulmonary hypertension in the setting of sarcoidosis-associated interstitial lung disease are a unique population which may potentially benefit from inhaled, targeted pulmonary arterial hypertension therapy (inhaled treprostinil) while minimizing the adverse effects associated with systemic pulmonary vasodilators. This study aims to evaluate the efficacy and safety of inhaled treprostinil in subjects with sarcoidosis-associated interstitial lung disease and pulmonary hypertension.

Eligibility criteria: Inclusion Criteria:

* Study participant willing and able to provide informed consent
* Negative urine pregnancy test at baseline for females of childbearing potential
* Established diagnosis of sarcoidosis by ATS/ERS/WASOG 1999 Statement on of Sarcoidosis
* Presence of interstitial lung disease by Scadding Stage IV chest radiograph or extensive fibrosis on chest computed tomography
* Right heart catheterization within six months of baseline visit showing precapillary pulmonary hypertension (mPAP ≥ 25 mmHg, PCWP ≤ 15 mmHg, and PVR \> 3 WU)
* Patient on stable sarcoidosis therapy for at least three months prior to screening
* If patients are on oral PAH therapy (PDE5i/SCGS and/or ERA) then dose should be stable for at least three months prior to screening
* A 6MWT within three months of screening visit of \> 100 meters

Exclusion Criteria:

* Pregnant patients or those who are actively lactating
* Patient not willing to use form of birth control (if applicable) during the study
* Inability to undergo 6MWT, RHC, PFTs or CMRI
* Predicted survival \< 6 months
* Patient on any prostanoid or prostanoid analog therapy
* Patients with left sided heart disease as defined by either a PCWP \> 15 mmHg and/or left ventricular ejection fraction \< 40%
* Use of any investigational drug/device, or participation in any investigational study with therapeutic intent within 30 days prior to randomization.

Primary outcomes:
measure: PVR by Right heart catheterization (RHC)
timeFrame: Baseline, Week 16
measure: mPAP by Right heart catheterization (RHC)
timeFrame: Baseline, Week 16
Secondary outcomes:
measure: Change in 6-Minute Walk Test (6MWT)
timeFrame: Baseline, Week 8, Week 16
measure: Change in Cardiac MRI parameters
timeFrame: Baseline, Week 16
measure: Change in Pulmonary Function Testing
timeFrame: Baseline, Week 16
measure: Change in Brain Natriuretic Peptide (BNP)
timeFrame: Baseline, Week 16
measure: Change in WHO Functional Class (WHO FC)
timeFrame: Baseline, Week 8, Week 16
Other outcomes:
Locations:
city: Gainesville
country: United States
facility: University of Florida, Division of Pulmonary and Critical Care Medicine
state: Florida
Study officials:
affiliation: University of Florida
name: Ali Ataya, MD
role: PRINCIPAL_INVESTIGATOR
References: