Clinical trial NCT06602024: A Study of mRNA-1010 Compared With a Licensed Influenza Vaccine in Adults ≥50 Years of Age
Official title: A Phase 3, Randomized, Observer-blind, Active-controlled, Case-driven Study to Investigate the Safety, Efficacy, and Immunogenicity of mRNA-1010 Candidate Seasonal Influenza Vaccine Compared With a Licensed Inactivated Seasonal Influenza Vaccine in Adults ≥50 Years of Age
Study type: INTERVENTIONAL
Overall status: ACTIVE_NOT_RECRUITING
Phase: PHASE3
Conditions: Seasonal Influenza
Keywords: Seasonal Influenza
Flu
mRNA-1010
Vaccine
Lead sponsor: ModernaTX, Inc.
Sponsor class: INDUSTRY
First posted: 2024-09-19
Enrollment: 56000
Sex: ALL
Minimum age (years): 50
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: PREVENTION

Brief summary: The primary objectives of this study are to evaluate the safety and reactogenicity of mRNA-1010, and to evaluate relative vaccine efficacy (rVE) of mRNA-1010 versus an active comparator against reverse transcription polymerase chain reaction (RT-PCR)-confirmed protocol-defined influenza-like illness (ILI) caused by any influenza A or B strains.


Eligibility criteria: Inclusion Criteria:

* Capable of giving signed informed consent, which includes compliance with the requirements and restrictions listed in the informed consent form (ICF) and in the protocol.
* Participants who are assigned female at birth or can become pregnant are eligible to participate if:

  * The participant is a person of nonchildbearing potential (PONCBP) or
  * The participant is a person of childbearing potential (POCBP) who:
* Is not breast/chest feeding.
* Is using an acceptable contraceptive method at least 28 days prior to Day 1 (Baseline) to at least 90 days after Day 1 (Baseline).
* Has a negative highly sensitive pregnancy test (urine or serum as required by local regulation or institutional review board \[IRB\]/independent ethics committee \[IEC\]) at the Screening Visit and before study intervention (if the Day 1 \[Baseline\] Visit is not on the same day as the Screening Visit).

Exclusion Criteria:

* Acutely ill or febrile (temperature ≥38.0 degrees Celsius (℃) \[100.4° Fahrenheit \[F\]\]) within 72 hours prior to Day 1 (Baseline).
* Close contact with someone with laboratory-confirmed influenza infection or with someone who has been treated with antiviral therapies for influenza (for example, Tamiflu®/oseltamivir) within 5 days prior to Day 1 (Baseline).
* History of a diagnosis or condition that, in the judgment of the Investigator, is clinically unstable or may affect participant safety, assessment of study endpoints, assessment of immune response, or adherence to study procedures.
* Reported history of congenital or acquired immunodeficiency, immunosuppressive condition, asplenia, or recurrent severe infections disease.
* Tested positive for influenza by local health authority-approved testing methods within 180 days prior to Day 1 (Baseline).
* History of anaphylaxis or severe hypersensitivity reaction requiring medical intervention after receipt of any of the following: mRNA vaccine or therapeutic; components of an mRNA vaccine or therapeutic; influenza vaccine; or components of an influenza vaccine, including egg protein.
* Malignancy within 2 years prior to Day 1 (Baseline) (adequately treated basal cell carcinoma and squamous cell carcinoma are allowed).
* Received corticosteroids at ≥10 milligram (mg)/day of prednisone or equivalent for \>14 days in total within 90 days prior to Day 1 (Baseline) or is anticipating the need for corticosteroids at any time during the study.
* Received systemic immunosuppressive treatment, including long-acting biological therapies that affect immune responses (for example, infliximab), within 180 days prior to Day 1 (Baseline) or plans to do so during the study.
* Treated with antiviral therapies for influenza (for example, Tamiflu) within 180 days prior to Day 1 (Baseline).
* Received any vaccine authorized or approved by local health agency within 28 days prior to Day 1 (Baseline) or plans to do so within 14 days after Day 1 (Baseline).
* Received a licensed seasonal influenza vaccine within 180 days prior to Day 1 (Baseline) or plans to do so (outside of this study) at any time during the study.
* Received an investigational seasonal influenza vaccine within 1 year prior to Day 1 (Baseline). Note: participants from mRNA-1010-P304 Season 1 are NOT eligible to re enroll into Season 2.
* Participated in a clinical study with investigational treatment within 90 days prior to Day 1 (Baseline) based on the medical history interview or plans to do so while participating in this study.
* Is working or has worked as study personnel or is an immediate family member or house member of study personnel, study staff, or Sponsor personnel.

Primary outcomes:
measure: Number of Participants with Solicited Local and Systemic Adverse Reactions (ARs)
timeFrame: Day 1 to Day 7
measure: Number of Participants with Unsolicited Adverse Events (AEs)
timeFrame: Day 1 to Day 28
measure: Number of Participants with Medically Attended AEs (MAAEs), AEs Leading to Discontinuation, Serious Adverse Events (SAEs), or Adverse Events of Special Interest (AESI)
timeFrame: Day 1 to Day 181
measure: Time to First Episode of RT-PCR Confirmed Protocol Defined ILI
timeFrame: Day 14 up to End of Season (up to approximately Day 181)
Secondary outcomes:
measure: Number of Participants with First Episode of RT-PCR Confirmed Modified US Centers for Disease Control and Prevention (CDC)-Defined ILI
timeFrame: Day 14 up to End of Season (up to approximately Day 181)
measure: Number of Participants with First Episode of RT-PCR Confirmed Protocol-Defined ILI or Modified CDC-Defined ILI
timeFrame: Day 14 up to End of Season (up to approximately Day 181)
measure: Geometric Mean Titer (GMT) of Hemagglutination Inhibition (HAI)
timeFrame: Day 29
measure: Number of Participants Reaching Seroconversion as Measured by HAI
timeFrame: Day 29
measure: Number of Participants with an HAI Titer ≥1:40
timeFrame: Day 29
measure: Geometric Mean Fold Rise (GMFR) of HAI Titers
timeFrame: Day 1, Day 29
measure: HAI Titers
timeFrame: Day 29
measure: Number of Participants with First Episode of RT-PCR-Confirmed Protocol-Defined ILI
timeFrame: Day 14 up to End of Season (up to approximately Day 181)
Other outcomes:
Locations:
city: Anniston
country: United States
facility: Pinnacle Research Group, Llc
state: Alabama
city: Athens
country: United States
facility: North Alabama Research Center, LLC
state: Alabama
city: Birmingham
country: United States
facility: Flourish Research
state: Alabama
city: Birmingham
country: United States
facility: EmVenio Research Brimingham, AL
state: Alabama
city: Cullman
country: United States
facility: Cullman Clinical Trials
state: Alabama
city: Huntsville
country: United States
facility: Optimal Research
state: Alabama
city: Mobile
country: United States
facility: Velocity Clinical Research
state: Alabama
city: Glendale
country: United States
facility: Lenzmeier Family Medicine
state: Arizona
city: Phoenix
country: United States
facility: DM Clinical Research
state: Arizona
city: Phoenix
country: United States
facility: Helios Clinical Research
state: Arizona
city: Tempe
country: United States
facility: Fiel Family and Sports Medicine
state: Arizona
city: Tucson
country: United States
facility: Arizona Liver Health
state: Arizona
city: Little Rock
country: United States
facility: Baptist Health Center for Clinical Research
state: Arkansas
city: Rogers
country: United States
facility: Woodland Research
state: Arkansas
city: Colton
country: United States
facility: Benchmark Research - Colton
state: California
city: Covina
country: United States
facility: Flourish Research
state: California
city: Huntington Park
country: United States
facility: Velocity Clinical Research - Huntington Park
state: California
city: La Mesa
country: United States
facility: Velocity Clinical Research, San Diego
state: California
city: Long Beach
country: United States
facility: Long Beach Research Institute LLC
state: California
city: Los Angeles
country: United States
facility: Velocity Clinical Research - Westlake
state: California
city: Newport Beach
country: United States
facility: M3 Wake Research/PRI, LLC
state: California
city: North Hollywood
country: United States
facility: Carbon Health North Hollywood
state: California
city: Northridge
country: United States
facility: Valley Clinical Trials, Inc.
state: California
city: Redding
country: United States
facility: Paradigm Research
state: California
city: Riverside
country: United States
facility: Artemis Institute for Clinical Research
state: California
city: Rolling Hills Estates
country: United States
facility: Peninsula Research Associates (PRA)
state: California
city: San Bernardino
country: United States
facility: Velocity Clinical Research - Banning
state: California
city: San Diego
country: United States
facility: Artemis Institute for Clinical Research - Research Site
state: California
city: San Diego
country: United States
facility: WHCR- M3 Wake Research
state: California
city: San Diego
country: United States
facility: Wr-McCr, Llc
state: California
city: Santa Ana
country: United States
facility: Velocity Clinical Research
state: California
city: Walnut Creek
country: United States
facility: Diablo Clinical Research
state: California
city: Fort Collins
country: United States
facility: Tekton Research - Fort Collins
state: Colorado
city: Longmont
country: United States
facility: Tekton Research, Inc - Longmont Center
state: Colorado
city: Stamford
country: United States
facility: Stamford Therapeutics Consortium
state: Connecticut
city: Waterbury
country: United States
facility: Chase Medical Research, LLC
state: Connecticut
city: Atlantis
country: United States
facility: JEM Research Institue
state: Florida
city: Crystal River
country: United States
facility: Nature Coast Clinical Research, LLC - Crystal River
state: Florida
city: Hialeah
country: United States
facility: Homestead Associates in Research,Inc
state: Florida
city: Hollywood
country: United States
facility: CenExel RCA
state: Florida
city: Inverness
country: United States
facility: Nature Coast Clinical Research, LLC - Inverness
state: Florida
city: Jacksonville
country: United States
facility: Westside Center for Clinical Research
state: Florida
city: Jacksonville
country: United States
facility: Jacksonville Center for Clinical Research
state: Florida
city: Jupiter
country: United States
facility: Health Awareness INC
state: Florida
city: Lake City
country: United States
facility: M3 Wake Research/MSRA,LLC
state: Florida
city: Lake Mary
country: United States
facility: Accel Clinical Research
state: Florida
city: Leesburg
country: United States
facility: Clinical Site Partners - Leesburg
state: Florida
city: Maitland
country: United States
facility: ARS - Meridien Research
state: Florida
city: Maitland
country: United States
facility: K2 medical research
state: Florida
city: Miami Lakes
country: United States
facility: Floridian Clinical Research
state: Florida
city: Miami
country: United States
facility: South Florida Research Center, Inc.
state: Florida
city: Miami
country: United States
facility: Miami Clinical Research
state: Florida
city: Miami
country: United States
facility: Suncoast Research Associates, LLC
state: Florida
city: Orlando
country: United States
facility: Headlands Research
state: Florida
city: Pembroke Pines
country: United States
facility: Suncoast Research Associates
state: Florida
city: Port Saint Lucie
country: United States
facility: Health Awareness INC
state: Florida
city: Saint Petersburg
country: United States
facility: IMA Clinical Research Warren
state: Florida
city: Tampa
country: United States
facility: Forward Clinical Trials - Dermatology
state: Florida
city: Winter Park
country: United States
facility: Clinical Site Partners, LLC
state: Florida
city: Albany
country: United States
facility: JAVARA
state: Georgia
city: Columbus
country: United States
facility: IACT Health
state: Georgia
city: Decatur
country: United States
facility: CenExel iResearch , LLC
state: Georgia
city: Savannah
country: United States
facility: CenExel iResearch Savannah
state: Georgia
city: Savannah
country: United States
facility: Velocity Clinical Research-Savannah
state: Georgia
city: Savannah
country: United States
facility: Javara - Privia Medical Group Georgia, LLC
state: Georgia
city: Stockbridge
country: United States
facility: Clinical Research Atlanta/Headlands
state: Georgia
city: Honolulu
country: United States
facility: East-West Medical Research Institute
state: Hawaii
city: Blackfoot
country: United States
facility: Bingham Memorial Hospital
state: Idaho
city: Meridian
country: United States
facility: Velocity Clinical Research - Boise
state: Idaho
city: Chicago
country: United States
facility: EmVenio Research
state: Illinois
city: Chicago
country: United States
facility: Great Lakes Clinical Trials
state: Illinois
city: Melrose Park
country: United States
facility: DM Clinical Research- River Forest
state: Illinois
city: Valparaiso
country: United States
facility: Velocity Clinical Research - Valparaiso
state: Indiana
city: Sioux City
country: United States
facility: Velocity Clinical Research-Sioux City
state: Iowa
city: Augusta
country: United States
facility: Alliance for Multispecialty Research
state: Kansas
city: Lenexa
country: United States
facility: Johnson County Clin-Trials (JCCT)
state: Kansas
city: Overland Park
country: United States
facility: DelRicht Research - Overland Park
state: Kansas
city: Wichita
country: United States
facility: AMR
state: Kansas
city: Baton Rouge
country: United States
facility: Velocity Clinical Research - Baton Rouge
state: Louisiana
city: Lafayette
country: United States
facility: Velocity Clinical Research - Lafayette
state: Louisiana
city: Monroe
country: United States
facility: IMA Clinical Research Monroe
state: Louisiana
city: New Orleans
country: United States
facility: DelRicht Research
state: Louisiana
city: New Orleans
country: United States
facility: Velocity Clinical Research
state: Louisiana
city: Prairieville
country: United States
facility: DelRicht Research @ Neighborhood Health
state: Louisiana
city: Annapolis
country: United States
facility: Privia Medical Group
state: Maryland
city: Gaithersburg
country: United States
facility: Cenexel CBH (CBH Health)
state: Maryland
city: Rockville
country: United States
facility: Matthew Mintz Clinic
state: Maryland
city: Rockville
country: United States
facility: Velocity Clinical Research - Covington
state: Maryland
city: Brookline
country: United States
facility: DM Clinical Research - Brookline
state: Massachusetts
city: Southfield
country: United States
facility: Headlands Research - Detroit
state: Michigan
city: Southfield
country: United States
facility: Great Lakes Research Institute
state: Michigan
city: Southfield
country: United States
facility: DM Clinical Research
state: Michigan
city: Gulfport
country: United States
facility: DELRICHT RESEARCH at GULFPORT MEMORIAL
state: Mississippi
city: Chesterfield
country: United States
facility: Clinical Research Professionals
state: Missouri
city: Saint Louis
country: United States
facility: Sundance Clinical Research, LLC
state: Missouri
city: Springfield
country: United States
facility: Clinvest
state: Missouri
city: Springfield
country: United States
facility: Delricht Research
state: Missouri
city: Town And Country
country: United States
facility: Delricht
state: Missouri
city: Missoula
country: United States
facility: Boeson Research MSO
state: Montana
city: Missoula
country: United States
facility: Elias Research Associates
state: Montana
city: Grand Island
country: United States
facility: Velocity Clinical Research-Grand Island
state: Nebraska
city: Lincoln
country: United States
facility: Platinum Research Network, LLC
state: Nebraska
city: Norfolk
country: United States
facility: Velocity Clinical Research-Norfolk
state: Nebraska
city: Omaha
country: United States
facility: Velocity Clinical Research-Omaha
state: Nebraska
city: Henderson
country: United States
facility: Henderson Clinical Trials
state: Nevada
city: Las Vegas
country: United States
facility: M3 Wake Research/CRCN, LLC
state: Nevada
city: Las Vegas
country: United States
facility: Office of Michael B. Jacobs, MD
state: Nevada
city: Jersey City
country: United States
facility: DM Clinical Research - New Jersey
state: New Jersey
city: Warren
country: United States
facility: IMA Clinical Research Warren
state: New Jersey
city: Albuquerque
country: United States
facility: DM Clinical Research-Albuquerque
state: New Mexico
city: Albuquerque
country: United States
facility: AXCES Research Group - Sante Fe
state: New Mexico
city: Binghamton
country: United States
facility: Velocity Clinical Research - Binghamton
state: New York
city: Brooklyn
country: United States
facility: DM Clinical
state: New York
city: Buffalo
country: United States
facility: RCR Buffalo
state: New York
city: East Syracuse
country: United States
facility: Velocity Clinical Research, Syracuse
state: New York
city: Hartsdale
country: United States
facility: IMA Clinical Research
state: New York
city: New York
country: United States
facility: IMA Research
state: New York
city: Rochester
country: United States
facility: Rochester Clinical Research, Inc
state: New York
city: Vestal
country: United States
facility: Velocity Clinical Research-Vestal
state: New York
city: Asheville
country: United States
facility: Asheville Clinical Research
state: North Carolina
city: Charlotte
country: United States
facility: DelRicht Research, LLC
state: North Carolina
city: Morehead City
country: United States
facility: Lucas Research
state: North Carolina
city: Raleigh
country: United States
facility: Eximia Clinical Research
state: North Carolina
city: Raleigh
country: United States
facility: M3 Wake Research, Inc.
state: North Carolina
city: Salisbury
country: United States
facility: Accellacare US Inc.
state: North Carolina
city: Wilmington
country: United States
facility: Accellacare Research Wilmington
state: North Carolina
city: Wilmington
country: United States
facility: Trial Management Associates, LLC
state: North Carolina
city: Winston-Salem
country: United States
facility: Javara - Wake Forest University Health Sciences
state: North Carolina
city: Cincinnati
country: United States
facility: Community Research
state: Ohio
city: Cincinnati
country: United States
facility: Velocity Clinical Research-Mt. Auburn
state: Ohio
city: Cincinnati
country: United States
facility: Velocity Clinical Research - Cincinnati
state: Ohio
city: Columbus
country: United States
facility: Centricity Research Columbus
state: Ohio
city: Dayton
country: United States
facility: Midwest Clinical Research Center
state: Ohio
city: Edmond
country: United States
facility: Tekton Research, Inc - Edmond
state: Oklahoma
city: Tulsa
country: United States
facility: Delricht Tate
state: Oklahoma
city: Yukon
country: United States
facility: Tekton Research, Inc - Yukon Location
state: Oklahoma
city: Corvallis
country: United States
facility: The Corvallis Clinic
state: Oregon
city: Portland
country: United States
facility: Summit Research
state: Oregon
city: Philadelphia
country: United States
facility: DM Clinical Research - Philadelphia
state: Pennsylvania
city: Uniontown
country: United States
facility: Preferred Primary Care Physicians
state: Pennsylvania
city: Providence
country: United States
facility: Velocity Clinical Research - Providence
state: Rhode Island
city: Anderson
country: United States
facility: Velocity Clinical Research - Anderson
state: South Carolina
city: Charleston
country: United States
facility: DelRicht Research
state: South Carolina
city: Charleston
country: United States
facility: Charleston Clinical Trials, LLC
state: South Carolina
city: Columbia
country: United States
facility: Velocity Clinical Research, Spartanburg
state: South Carolina
city: Gaffney
country: United States
facility: Velocity Clinical Research, Gaffney
state: South Carolina
city: Myrtle Beach
country: United States
facility: Carolina Health Specialists
state: South Carolina
city: Spartanburg
country: United States
facility: Spartanburg Medical Research
state: South Carolina
city: Union
country: United States
facility: Velocity Clinical Research- UNION
state: South Carolina
city: Rapid City
country: United States
facility: Black Hills Center for American Indian Health
state: South Dakota
city: Chattanooga
country: United States
facility: M3 Wake Research/ClinSearch, LLC
state: Tennessee
city: Jackson
country: United States
facility: Helios Clinical Research
state: Tennessee
city: Johnson City
country: United States
facility: MultiSpeciality Clinical Research
state: Tennessee
city: Austin
country: United States
facility: Avant Reseach Associates
state: Texas
city: Austin
country: United States
facility: Tekton Research, Inc
state: Texas
city: Beaumont
country: United States
facility: Tekton Research, LLC
state: Texas
city: Brownsville
country: United States
facility: Headlands Research Brownsville
state: Texas
city: El Paso
country: United States
facility: 3A Research, LLC
state: Texas
city: Fort Worth
country: United States
facility: Helios
state: Texas
city: Fort Worth
country: United States
facility: Benchmark Research
state: Texas
city: Houston
country: United States
facility: Helios Clinical Research
state: Texas
city: Houston
country: United States
facility: DM Clinical Research - CyFair
state: Texas
city: Houston
country: United States
facility: DM Clinical Research- Bellaire
state: Texas
city: Keller
country: United States
facility: Helios CR, Inc. Keller Tx
state: Texas
city: Plano
country: United States
facility: Research Your Health
state: Texas
city: Prosper
country: United States
facility: DELRICHT RESEARCH at ZOMNIR FAMILY MEDICINE
state: Texas
city: San Antonio
country: United States
facility: DM Clinical Research
state: Texas
city: San Antonio
country: United States
facility: IMA Clinical Research
state: Texas
city: San Antonio
country: United States
facility: Tekton Research Inc - San Antonio
state: Texas
city: San Marcos
country: United States
facility: San Marcos Family Medicine
state: Texas
city: Stephenville
country: United States
facility: Stephenville Medical & Surgical Clinic, PA
state: Texas
city: Sugar Land
country: United States
facility: Breco Research - A Tarheel Clinical Research Site
state: Texas
city: Sugar Land
country: United States
facility: DM Clinical Research - Sugarland
state: Texas
city: Tomball
country: United States
facility: DM Clinical Research - Tomball
state: Texas
city: Tomball
country: United States
facility: DM Clinical Research
state: Texas
city: Salt Lake City
country: United States
facility: Synexus Clinical Research US, Inc.
state: Utah
city: Salt Lake City
country: United States
facility: CenExel - JBR
state: Utah
city: Salt Lake City
country: United States
facility: J. Lewis Research, Inc. / Foothill Family Clinic
state: Utah
city: Salt Lake City
country: United States
facility: J. Lewis Research, Inc.
state: Utah
city: South Jordan
country: United States
facility: J. Lewis Research, Inc/Jordan River Family Medicine
state: Utah
city: Alexandria
country: United States
facility: Javara
state: Virginia
city: Hampton
country: United States
facility: Velocity Clinical Research-Hampton
state: Virginia
city: Newport News
country: United States
facility: Health Research of Hampton Roads, Inc.
state: Virginia
city: Portsmouth
country: United States
facility: Velocity Clinical Research-Portsmouth
state: Virginia
city: Richmond
country: United States
facility: Clinical Research Partners, LLC
state: Virginia
city: Winchester
country: United States
facility: Amherst Family Practice
state: Virginia
city: Spokane
country: United States
facility: Velocity Clinical Research- Spokane
state: Washington
city: Wenatchee
country: United States
facility: Confluence Health
state: Washington
city: Alken
country: Belgium
facility: Anima Research Center
city: Gent
country: Belgium
facility: Universitair Ziekenhuis Gent
city: Mechelen
country: Belgium
facility: AZ Sint Maarten
city: Wilrijk
country: Belgium
facility: University of Antwerpen - Vaccinopolis
city: Burgas
country: Bulgaria
facility: Medical center "Dr. Staykov" Ltd.
city: Kozloduy
country: Bulgaria
facility: MHAT "Sveti Ivan Rilski"
city: Lovech
country: Bulgaria
facility: Medical Center Medconsult Pleven, Lovech branch
city: Montana
country: Bulgaria
facility: Medical Center Hera - Montana branch
city: Montana
country: Bulgaria
facility: MHAT "Dr. Stamen Iliev"
city: Pleven
country: Bulgaria
facility: Medical Center Medconsult Pleven
city: Plovdiv
country: Bulgaria
facility: AIPPMP Dr. Levena Kireva
city: Plovdiv
country: Bulgaria
facility: MHAT "Sv. Panteleymon" Ltd.
city: Sliven
country: Bulgaria
facility: DCC-1 Sliven Lts.
city: Sliven
country: Bulgaria
facility: MHAT Sliven to MMA Sofia
city: Sofia
country: Bulgaria
facility: Diagnostic & Consultancy Center Ascendent, Sofia
city: Sofia
country: Bulgaria
facility: Medical Center "Hera" EOOD
city: Sofia
country: Bulgaria
facility: Medical Center Excelsior - Base 2
city: Sofia
country: Bulgaria
facility: Medical Center Excelsior OOD, Base1
city: Sofia
country: Bulgaria
facility: Medical Centre "Sirtuin" Ltd
city: Stamboliyski
country: Bulgaria
facility: AIPPMP D-r Zhaneta Demireva Ltd.
city: Burlington
country: Canada
facility: Aviva Medical Diagnostics and Specialists Clinic and Heart & Vascular Centre
city: Calgary
country: Canada
facility: CARe Clinic, Calgary, AB
city: Levis
country: Canada
facility: Centricity Research Quebec City
city: London
country: Canada
facility: Milestone Research Inc.
city: Ottawa
country: Canada
facility: Red Maple Trials
city: Pointe Claire
country: Canada
facility: Centricity Research Pointe-Claire
city: Québec
country: Canada
facility: Clinique de Lebourgneuf
city: Red Deer
country: Canada
facility: CARe , Red Deer, AB.
city: Sarnia
country: Canada
facility: Bluewater Clinical Research Group Inc.
city: Stouffville
country: Canada
facility: Stouffville Medical Research Institute
city: Toronto
country: Canada
facility: Canadian Phase Onward Inc.
city: Toronto
country: Canada
facility: Centricity Research Toronto LMC
city: Trois-Rivières
country: Canada
facility: Diex Recherche
city: Truro
country: Canada
facility: Colchester Research Group
city: Victoriaville
country: Canada
facility: Diex Recherche Victoriaville
city: Paide
country: Estonia
facility: Vee Family Doctors' Center
city: Tallinn
country: Estonia
facility: Center of Clinical and Basic Research
city: Tallinn
country: Estonia
facility: Merelahe Family Doctors Centre
city: Tallinn
country: Estonia
facility: Innomedica OU
city: Tartu
country: Estonia
facility: Clinical Research Center
city: Espoo
country: Finland
facility: FVR - Finnish Vaccine Research Ltd - Espoo
city: Kokkola
country: Finland
facility: FVR - Finnish Vaccine Research Ltd - Kokkola
city: Oulu
country: Finland
facility: FVR - Finnish Vaccine Research Ltd - Oulu
city: Tampere
country: Finland
facility: FVR - Finnish Vaccine Research Ltd - Tampere
city: Turku
country: Finland
facility: FVR - Finnish Vaccine Research Ltd - Järvenpää
city: Batumi
country: Georgia
facility: Unimed Adjara Ltd - Batumi Referral Hospital
city: Kutaisi
country: Georgia
facility: LTD "Hospital service"
city: Rustavi
country: Georgia
facility: LTD Clinic Rustavi
city: Tbilisi
country: Georgia
facility: Emergency Cardiology Center named by acad. G. Chapidze
city: Tbilisi
country: Georgia
facility: Eristavi National Center of Experimental and Clinical Surgery
city: Tbilisi
country: Georgia
facility: LTD Israel-Georgian Medical Research Clinic Helsicore
city: Berlin
country: Germany
facility: Emovis GmbH
city: Berlin
country: Germany
facility: Klinische Forschung Berlin-Mitte GmbH
city: Berlin
country: Germany
facility: Velocity Clinical Research Berlin, GmbH
city: Bochum
country: Germany
facility: Praxis Rinke
city: Dresden
country: Germany
facility: Klinische Forschung Dresden GmbH
city: Essen
country: Germany
facility: Medizentrum Essen Borbeck
city: Frankfurt
country: Germany
facility: IKF Pneumologie
city: Frankfurt
country: Germany
facility: Infektio Research GmbH & Co.KG
city: Hamburg
country: Germany
facility: Klinische Forschung Hamburg GmbH
city: Hamburg
country: Germany
facility: Velocity Clincial Research Hamburg GmbH
city: Hannover
country: Germany
facility: Klinische Forschung Hannover Mitte GmbH
city: Karlsruhe
country: Germany
facility: Klinische Forschung Karlsruhe
city: Magdeburg
country: Germany
facility: SMO.MD
city: Mainz
country: Germany
facility: Dermatologie Quist BAG Dres. Med. Quist Part G
city: München
country: Germany
facility: CDG Studienambulanz
city: Offenbach
country: Germany
facility: Future meds Offenbach
city: Oldenburg
country: Germany
facility: Red-Institut
city: Schwerin
country: Germany
facility: Klinische Forschung Schwerin GmbH
city: Stuhr
country: Germany
facility: Studienzentrum Brinkum
city: Stuttgart
country: Germany
facility: Hautarztpraxis Leitz & Kollegen
city: Wiesbaden
country: Germany
facility: Velocity Clinical Research Wiesbaden
city: Ansan-Si
country: Korea, Republic of
facility: Korea University Ansan Hospital
city: Bucheon-Si
country: Korea, Republic of
facility: Soon Chun Hyang University Hospital Bucheon
city: Daejeon
country: Korea, Republic of
facility: Chungnam National University Hospital
city: Incheon
country: Korea, Republic of
facility: Inha University Hospital
city: Seoul
country: Korea, Republic of
facility: Hallym University Kangnam Sacred Heart Hospital
city: Seoul
country: Korea, Republic of
facility: Seoul National University Hospital
city: Seoul
country: Korea, Republic of
facility: Severance Hospital, Yonsei University Health System
city: Suwon-Si
country: Korea, Republic of
facility: Ajou University Hospital
city: Wonju-si
country: Korea, Republic of
facility: Yonsei University, Wonju Severance Christian Hospital
city: Kaohsuing City
country: Taiwan
facility: Kaohsiung Veterans General Hospital
city: Taichung City
country: Taiwan
facility: China Medical University Hospital
city: Taipei City
country: Taiwan
facility: National Taiwan University Hospital
city: Taoyuan City
country: Taiwan
facility: Chang Gung Medical Foundation - LinKou Chang Gung Memorial Hospital
city: Acomb, York
country: United Kingdom
facility: Panthera Biopartners site - York
city: Birmingham
country: United Kingdom
facility: FutureMeds Birmingham
city: Birmingham
country: United Kingdom
facility: University Hospitals Birmingham NHS Foundation Trust
city: Blackpool
country: United Kingdom
facility: Layton Medical Centre
city: Corby
country: United Kingdom
facility: Lakeside Healthcare
city: Edinburgh
country: United Kingdom
facility: NHS Lothian - Western General Hospital
city: Enfield
country: United Kingdom
facility: Panthera Biopartners site - Enfield
city: Exeter
country: United Kingdom
facility: Royal Devon University Healthcare NHS Foundation Trust
city: Glasgow
country: United Kingdom
facility: FutureMeds - Glasgow
city: Glasgow
country: United Kingdom
facility: Glasgow Panthera Biopartners Site
city: London
country: United Kingdom
facility: Barts Health NHS Trust - Mile End Hospital
city: London
country: United Kingdom
facility: Chelsea and Westminster Hospital NHS Foundation Trust
city: London
country: United Kingdom
facility: Guy's and St Thomas's NHS Foundation Trust
city: London
country: United Kingdom
facility: HMC Research Group
city: London
country: United Kingdom
facility: St George's University Hospitals (NHS Foundation Trust)
city: London
country: United Kingdom
facility: Velocity Clinical Research - North London
city: Manchester
country: United Kingdom
facility: Manchester University NHS Foundation Trust
city: Newcastle upon Tyne
country: United Kingdom
facility: Infectious Diseases Research - Clinical Research Facility
city: Norwich
country: United Kingdom
facility: Norfolk nand Norwich University Hospital
city: Nottingham
country: United Kingdom
facility: University of Nottingham Health Service
city: Peterborough
country: United Kingdom
facility: Wansford Research Limited
city: Plymouth
country: United Kingdom
facility: University Hospitals Plymouth NHS Trust
city: Portsmouth
country: United Kingdom
facility: Portsmouth Hospitals University NHS Trust - Portsmouth Research Hub
city: Rochdale
country: United Kingdom
facility: Panthera Biopartners - Manchester
city: Sheffield
country: United Kingdom
facility: Sheffield Panthera Biopartners Site
city: Southampton
country: United Kingdom
facility: Southampton General Hospital
city: Stockton-on-Tees
country: United Kingdom
facility: Future Meds - Teesside
city: Wirral
country: United Kingdom
facility: FutureMeds Wirral
Study officials:
References: