Clinical trial NCT04194047: Effects of Red Blood Cells Transfusion on Renal Blood Flow
Official title: Effects of Red Blood Cells Transfusion on Renal Resistivity Index and Renal Venous Stasis Index
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Acute Kidney Injury
Transfusion-Associated Circulatory Overload
Anemia
Fluid Overload
Lead sponsor: Università degli Studi di Ferrara
Sponsor class: OTHER
First posted: 2019-12-11
Enrollment: 33
Sex: ALL
Minimum age (years): 18
Maximum age (years): 90
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: Cohort of critically ill patients

Brief summary: The renal Doppler resistive index (RRI) is a noninvasive tool that has been used to assess renal perfusion in the intensive care unit (ICU) setting. It is associated with the occurrence of acute kidney injury (AKI). Many parameters have been described as influential on the values of renal RI. Red blood cell (RBC) transfusion were shown to be able to increase renal oxygenation in animal model, whereas crystalloid resuscitation did not. We sought to describe the different effect of crystalloids infusion and RBC transfusion on renal blood flow, as evaluated with doppler ultrasound


Eligibility criteria: Inclusion Criteria:

* Age \> 18 and \< 90
* Hemoglobin ≥7 and ≤ 10 g/dl

Exclusion Criteria:

* Ultrasound RRI evaluation non available
* Patients with arrhythmia
* Pregnancy
* Refusal to give consent
* History of renal transplantation
* Central venous access in superior vena cava not available Critical active bleeding

Primary outcomes:
measure: Change in renal resistivity index (RRI) after intervention
timeFrame: after 60 minute from intervention
measure: Change Renal Venous Stasis Index (RSVI) after intervention
timeFrame: after 60 minute from intervention
Secondary outcomes:
measure: Occurence of AKI
timeFrame: Once a day for 7 days
measure: Variation in renal resistivity index (RRI)
timeFrame: after 24 hours from intervention
measure: Variation in Renal Venous Stasis Index (RSVI)
timeFrame: after 24 hours from intervention
Other outcomes:
measure: correlation between arterial-venous oxygen differences and changes in renal resistivity index (RRI) after intervention
timeFrame: after 24 hours from intervention
measure: correlation between arterial-venous oxygen differences and changes in Renal Venous Stasis Index (RSVI)
timeFrame: after 24 hours from intervention
Locations:
city: Ferrara
country: Italy
facility: Università di Ferrara
Study officials:
References:
citation: Zafrani L, Ergin B, Kapucu A, Ince C. Blood transfusion improves renal oxygenation and renal function in sepsis-induced acute kidney injury in rats. Crit Care. 2016 Dec 20;20(1):406. doi: 10.1186/s13054-016-1581-1.
citation: Husain-Syed F, Birk HW, Ronco C, Schormann T, Tello K, Richter MJ, Wilhelm J, Sommer N, Steyerberg E, Bauer P, Walmrath HD, Seeger W, McCullough PA, Gall H, Ghofrani HA. Doppler-Derived Renal Venous Stasis Index in the Prognosis of Right Heart Failure. J Am Heart Assoc. 2019 Nov 5;8(21):e013584. doi: 10.1161/JAHA.119.013584. Epub 2019 Oct 19.