louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT05830370: Prevalence of Intestinal Parasitic Infections in Patients With Irritable Bowel Syndrome
Official title: Prevalence of Intestinal Parasitic Infections in Irritable Bowel Syndrome Patients in Sohag, Egypt
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Irritable Bowel Syndrome
Keywords: irritable bowel syndrome
entamoeba
histolytica
Blastocystis
hominis
chronic abdominal pain
diarrhea
defecation
constipation
bloating
Trichinella
Cryptosporidium
Lead sponsor: Sohag University
Sponsor class: OTHER
First posted: 2023-04-26
Enrollment: 200
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: CASE_CONTROL
Time perspective: OTHER
Sampling method: PROBABILITY_SAMPLE
Study population: samples will be collected from outpatients complaining of symptoms of IBS fulfilling the Rome criteria , such as abdominal discomfort, diarrhea, and constipation, bloating with any age \& sex groups from different locations (cities and village).

Brief summary: Irritable bowel syndrome (IBS) is common medical disorder and represent a group of diseases of the gastrointestinal tract that is characterized by chronic abdominal pain , bloating , passage of mucus or straining with bowel movements, sense of incomplete evacuation after bowel movements or sense of urgency to move the bowels.Several parasites including Entamoeba. histolytica, Giardia spp., Blastocystis. hominis, and Trichinella spp. have been discussed as contributing factors to the development of IBS.

B. hominis is one of the most common human intestinal protozoa in both developing and developed countries. some studies have reported a significant association between the parasitic infections, especially Blastocystis, and IBS.Cryptosporidium has been reported in IBS patients, with the onset of gastrointestinal symptoms after an acute episode of cryptosporidiosis despite recovery and parasite clearance.Numerous studies have been conducted to evaluate the association between the parasitic infections and IBS.

Aim of the work:

To detect prevalence of intestinal parasitic infections in irritable bowel syndrome patients in sohag.


Eligibility criteria: Inclusion Criteria:

* Patients complaining of symptoms of IBS, such as abdominal discomfort, diarrhea, and constipation, bloating with any age \& sex groups

Exclusion Criteria:

* Patients have celiac disease, gastrointestinal malignancies , inflammatory bowel disease , HIV , and those on immunosuppression and those who had been recently taking antibiotics within the previous four weeks and anti-parasitic drugs within the previous two weeks.

Primary outcomes:
measure: To detect prevalence of intestinal parasitic infections in irritable bowel syndrome patients in sohag.
timeFrame: 16 weeks following the startpoint of the study.
Secondary outcomes:
Other outcomes:
Locations:
city: Sohag
country: Egypt
facility: Faculty of Medicine Sohag University
Study officials:
References:
Clinical trial NCT02997475: Neural Bases of Multiple Forms of Self-regulatory Control in Bulimia Nervosa
Official title: Neural Bases of Multiple Forms of Self-regulatory Control in Bulimia Nervosa
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Bulimia Nervosa
Keywords: Bulimia Nervosa
Bulimia
fMRI
Emotion Regulation
Response Inhibition
Lead sponsor: University of California, San Diego
Sponsor class: OTHER
Collaborators: name: National Institute of Mental Health (NIMH)
name: The Hilda & Preston Davis Foundation
First posted: 2016-12-20
Enrollment: 89
Sex: FEMALE
Minimum age (years): 18
Maximum age (years): 35
Standard ages: ADULT
Accepts healthy volunteers: yes
Observational model: CASE_CONTROL
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Women (ages 18-35 years) with bulimia nervosa, and age- and BMI-matched healthy controls.

Brief summary: The purpose of this study is to investigate areas of the brain responsible for self-regulation in adult women who have never had an eating disorder with women who have bulimia nervosa. More specifically, investigators are interested in changes in brain activation (e.g., changes in blood flow and oxygen use) when inhibiting responses and regulating emotions. Data collection will rely on a technology called functional magnetic resonance imaging (fMRI).


Eligibility criteria: General Inclusion Criteria:

* Female
* Right-handed
* Between the ages of 18 and 35 years

  \*For Women with Bulimia Nervosa:
* Binge eating (i.e., eating a large amount of food while experiencing a sense of loss of control)
* Purging via self-induced vomiting (other methods may also be endorsed)

General Exclusion Criteria:

* Current significant medical illness or condition (e.g., diabetes, thyroid disease)
* Pregnancy, planned pregnancy, or lactation during the study period
* Non-removable metallic objects in the body

Primary outcomes:
measure: Self-Regulatory Control
timeFrame: Day 2 (fMRI Scan)
Secondary outcomes:
measure: Goal-Directed Action Control
timeFrame: Day 1
measure: Eating Disorder Relevance
timeFrame: Day 0
Other outcomes:
Locations:
city: San Diego
country: United States
facility: UCSD Eating Disorders Center for Treatment and Research
state: California
Study officials:
affiliation: University of California, San Diego
name: Laura A. Berner, Ph.D.
role: STUDY_DIRECTOR
References:
Clinical trial NCT04202575: Elimination of CO2-insufflation-induced Hypercarbia in Open Heart Surgery
Official title: Elimination of CO2-insufflation-induced Hypercarbia in Open Heart Surgery Using a Separate Reservoir for Suction of Blood From the Open Surgical Wound
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Adult Patients Undergoing Open Heart Replacement of the Aortic Valve for Aortic Stenosis or Insufficiency
Lead sponsor: Karolinska University Hospital
Sponsor class: OTHER
First posted: 2019-12-17
Enrollment: 10
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NON_RANDOMIZED
Intervention model: CROSSOVER
Primary purpose: TREATMENT

Brief summary: The study aim was to evaluate if an additional separate venous reservoir eliminates CO2-insufflation induced hypercapnia and keeps sweep gas flow of the oxygenator constant during open heart surgery.

Detailed description: Background: CO2-gas insufflation is used for continuous de-airing during open heart surgery. The study aim was to evaluate if an additional separate venous reservoir eliminates CO2-insufflation induced hypercapnea and keeps sweep gas flow of the oxygenator constant.

Methods: A separate small reservoir are used during CPB in addition to a standard large venous reservoir. The small reservoir receive drained wound blood and CO2-gas continuously via a suction drain (1 L/min) and handheld suction devices from the open surgical wound. CO2-gas is insufflated via a gas-diffuser in the open surgical wound at 10 L/min. During cross-clamping, gas and blood are either continuously drained to the standard large venous reservoir or not, every 5 minutes after steady state of PaCO2 is observed, after adjustment of sweep gas flow as necessary. Mean values for each setup (2-4 times) for each patient will be analyzed with Wilcoxon rank-sum test.

Eligibility criteria: Inclusion Criteria:

* adult patients undergoing open heart replacement of the aortic valve
* Use of perioperative cardiopulmonary bypass

Exclusion Criteria:

* Denied participation in the study

Primary outcomes:
measure: Difference in PaCO2 (kPa)
timeFrame: At 5 minutes steady state
Secondary outcomes:
measure: Oxygenator sweep gas flow rate (L/min)
timeFrame: At 5 minutes steady state
Other outcomes:
Locations:
city: Stockholm
country: Sweden
facility: Karolinska University Hospital
Study officials:
References:
citation: Nyman J, Holm M, Fux T, Sesartic V, Fredby M, Svenarud P, van der Linden J. Elimination of CO2 insufflation-induced hypercapnia in open heart surgery using an additional venous reservoir. Interact Cardiovasc Thorac Surg. 2021 Aug 18;33(3):483-488. doi: 10.1093/icvts/ivab082.
Clinical trial NCT02859675: Olfactogustatory Perception, Eating Behaviour and Inflammation in Crohn's Disease
Official title: Olfactogustatory Perception, Eating Behaviour and Inflammation in Crohn's Disease
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Crohn's Disease
Olfactogustatory Perception
Lead sponsor: Centre Hospitalier Universitaire Dijon
Sponsor class: OTHER
First posted: 2016-08-09
Enrollment: 62
Sex: FEMALE
Minimum age (years): 18
Maximum age (years): 60
Standard ages: ADULT
Accepts healthy volunteers: yes
Observational model: CASE_ONLY
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: understanding of the mechanisms underlying anorexia in persons with Crohn's disease flare-ups

Brief summary: This study will improve our understanding of the mechanisms underlying anorexia in persons with Crohn's disease flare-ups. The practical spin-off from this research is potentially very important for the management of nutritional disorders associated with the disease by guiding diets towards foods that correspond to patients' preferences and/or to modified tastes. In addition, the results could lead to the identification of sensory markers that herald an inflammatory flare-up of the disease.


Eligibility criteria: For patients :

Inclusion Criteria:

* Age between 18 and 60 years,
* Diagnosis of Crohn's disease according to clinical, endoscopic, histological, radiological and biochemical criteria as defined by the European Consensus Conference,
* Men or women who have provided consent and willing to cooperate.

Exclusion Criteria:

* Chronic inflammatory intestinal disease (CIID) other than Crohn's disease: haemorrhagic rectocolitis, undetermined colitis, microscopic colitis.
* Intercurrent disease (diabetes and metabolic disease, liver cirrhosis, progressive cancer, acute or chronic infection, Human Immunodeficiency Virus HIV),
* Organ failure (respiratory, heart, or renal failure, neurological disorders),
* Intolerance to gluten,
* Treatments (other than those used for Crohn's disease) able to interfere with food intake,
* Aversion to foods consumed or smelled,
* Poor understanding of cognitive tasks required.
* Crohn's disease complicated by an abscess or infectious complication
* Acute Crohn's disease defined by a CDAI score \> 150

For Controls:

Inclusion Criteria:

* Adult person
* Without follow-up for a chronic pathology
* Having given its consent

Exclusion Criteria:

* Protected adult
* Person not affiliated to a social security system
* Pregnant or breastfeeding woman
* Active smoker
* No one who does not speak French
* Taking treatment that interferes with taste or acts on the central nervous system

Primary outcomes:
measure: Modification of sweet taste
timeFrame: through the study completion up to 10 years
Secondary outcomes:
Other outcomes:
Locations:
city: Dijon
country: France
facility: Centre Hospitalier Universitaire
Study officials:
References:
Clinical trial NCT05039775: Clitoral Therapy Device in Alleviating Sexual Dysfunction After Genital Mutilation.
Official title: Clitoral Therapy Device in Alleviating Sexual Dysfunction After Genital Mutilation of Females in Egypt.
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Sexual Dysfunction
Sexual Arousal Disorder
Keywords: Sexual arousal disorder
Lead sponsor: Badr University
Sponsor class: OTHER
First posted: 2021-09-10
Enrollment: 80
Sex: FEMALE
Minimum age (years): 20
Maximum age (years): 45
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The aim of this study to determine the effect of clitoral therapy device EROS device/ on sexual dysfunction after genital mutilation.

Detailed description: Little attention has been given to women who exposed to genital mutilation surgery in early age in the middle east. Most of them suffer from sexual dysfunction of sexual arousal and orgasm when they get in an intimate relation with their husbands after marriage. Clitoral therapy device may improve sexual arousal and alleviate sexual dysfunction symptoms to a great extent.

Eligibility criteria: Inclusion Criteria:

* All are suffering sexual dysfunction of sexual arousal and all referred from the family planning and reproductive health department, National research Center.

Exclusion Criteria:

* Metastatic disease, severe bowel or bladder sequelae, and significant comorbidities. Women with a history of sexual trauma or abuse, or undergoing current antidepressant therapy were excluded.

Primary outcomes:
measure: The Female Sexual Function Index (FSFI).
timeFrame: Change from baseline sexual function at 3 months.
Secondary outcomes:
Other outcomes:
Locations:
city: New Cairo
country: Egypt
facility: Badr University in Cairo
state: Badr City
Study officials:
affiliation: National Research Center
name: Amr Abbassy, PhD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT02626975: MRI Study of Ballooning and Ligamentisation Short Transplants ACL Hamstring According to Technical DT4
Official title: MRI Study of Ballooning and Ligamentisation Short Transplants ACL Hamstring According to Technical DT4
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Deficiency of Anterior Cruciate Ligament
Displacement of Bone Allograft
Keywords: knee
short hamstring autograft
ligament
MRI
Lead sponsor: University Hospital, Lille
Sponsor class: OTHER
First posted: 2015-12-10
Enrollment: 60
Sex: ALL
Minimum age (years): 18
Maximum age (years): 70
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: patients with an hamstring ACL ligamentoplasty with a follow up of at least 1 year

Brief summary: MRI study of ballooning and ligamentisation short transplants of anterior cruciate ligament (ACL) according to DT4 technique in 60 patients with more than one year of follow up.

Detailed description: Monocentric study in the CHRU Lille in which the first goal is to estimate the frequency of tunnel's ballooning in a surgical anterior cruciate ligament reconstruction using short transplants of hamstrings.

the secondary goals Secondary goals of this study are the estimation of ligamentisation if ballooning or not, the comparison of sagittal laximetry between "ballooned" group and "not ballooned"one, the clinical results in IKDC score (International Knee Documentation Committee subjective fee form) and KOOS (Knee injury Osteoarthritis Outcome Score) between the "ballooned" group and the "not ballooned"one.

Eligibility criteria: Inclusion Criteria:

* Adults patients of both sexes with an hamstring ACL ligamentoplasty done in our institution with a follow up of 1 year
* isolated ACL ligamentoplasty
* insured patients with a signed informed consent

Exclusion Criteria:

* follow up inferior of 1 year
* absolute contraindication to knee MRI
* gadolinium allergy
* severe renal failure
* non isolated ACL ligamentoplasty
* patient under guardianship, minor
* pregnant woman or nursing mother

Primary outcomes:
measure: frequency of balloonisation
timeFrame: 1 year
Secondary outcomes:
measure: frequency of ligamentisation
timeFrame: 1 year
measure: laximetry done with genurob*
timeFrame: 1 year
measure: Knee Injury and Osteoarthritis Outcome Score
timeFrame: 1 year
measure: International Knee Documentation Commitee (IKDC) Score
timeFrame: 1 year
Other outcomes:
Locations:
city: Lille
country: France
facility: University Hospital, Hôpital Salengro
Study officials:
affiliation: University Hospital, Lille
name: Gilles PASQUIER, MD, PhD
role: STUDY_CHAIR
References:
Clinical trial NCT03707275: Personalized Voice Activated Wellness Assistants for Patients With Heart Failure
Official title: Personalized Voice Activated Wellness Assistants for Patients With Heart Failure
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Heart Failure
Congestive Heart Failure
Keywords: Clinical trial
Patient-centered outcomes
Treatment of heart failure
Technology in heart failure
Lead sponsor: Medstar Health Research Institute
Sponsor class: OTHER
Collaborators: name: National Institutes of Health (NIH)
name: Georgetown-Howard Universities Center for Clinical and Translational Science
name: ObEN Artificial Intelligence
First posted: 2018-10-16
Enrollment: 50
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: OTHER

Brief summary: The Alexa+ Study will compare the use of the Amazon Echo Dot with Alexa voice technology in patients with chronic heart failure to those receiving standard of care heart failure management on changes in health and patient-centered outcomes.

Detailed description: Integrating data from virtual voice activated assistants (Amazon Echo Dot with Alexa voice technology), with the rich medical history available in Electronic Health Records (EHR) will allow a truly customized, interactive, and automated personal healthcare assistant. This technology will be validated in patients who have chronic heart failure (HF). Half of the study patients will receive an Amazon Echo Dot (Alexa) enhanced with a HF Care custom Alexa Skill that is patient-specific, or Alexa+. Data on patient interactions with the device will be followed for three months. The control groups will receive standard of care (SOC) HF management. Both study and control groups will receive regular follow up from the HF nurse and data from all hospital or clinic visits will be captured from the EHR.

Eligibility criteria: Inclusion Criteria:

* Heart failure patients seen at the MedStar heart failure clinic and the MedStar Washington Hospital Center inpatient heart failure service
* At least 18 years of age
* Have access to in-home Wi-Fi

Exclusion Criteria:

* Participation in another interventional clinical trial

Primary outcomes:
measure: Change in comfort level using Alexa+ technology as measured by the pre and post-test technology comfort survey
timeFrame: 3 months
Secondary outcomes:
measure: Change in number of hospitalizations as measured by hospitalization data extracted from the EHR
timeFrame: 3 months
measure: Change in medication adherence as measured by number of prescriptions filled extracted from the EHR
timeFrame: 3 months
Other outcomes:
Locations:
city: Washington
country: United States
facility: MedStar Washington Hospital Center
state: District of Columbia
Study officials:
affiliation: Medstar Health Research Institute
name: Nawar M Shara, M.S., PhD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT02220075: Fiberoptic Evaluation of the LMA(Laryngel Mask Airway) Position During Anesthesia With Spontaneous Respiration or Controlled Ventilation in Children
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Pediatric Urologic Surgery
Keywords: fiberoptic, LMA, caudal block
Lead sponsor: Yonsei University
Sponsor class: OTHER
First posted: 2014-08-19
Enrollment: 100
Sex: ALL
Minimum age (years): 1
Maximum age (years): 7
Standard ages: CHILD
Accepts healthy volunteers: no
Observational model: OTHER
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: Pediatric patients who are planed to get urologic surgery under general anesthesia using LMA

Brief summary: LMA(Laryngel Mask Airway) is useful for pediatrics surgery, and there are various methods of LMA insertion. When the investigators evaluate the LMA position, the investigators can use fiberoptic bronchoscope (Grade 1 to 4). For pediatric patients, clinical signs(airway pressure\<20cmH2O, expiratory CO2 level)are seen normal but the grade is 3 or 4. And this will bring high risk of aspiration. Recent studies reported the LMA position after general anesthesia induction not after operation. Therefore, the investigators will observe the LMA position three times; after general anesthesia induction, after caudal block, and after operation as well as the difference regarding to spontaneous and controlled ventilation.


Eligibility criteria: Inclusion Criteria:

1. ASA physical status 1 or 2,
2. pediatric patients from 1month to 7 years old
3. under general anesthesia using LMA
4. getting informed consent from the guardian

Exclusion Criteria:

1. difficult airway
2. airway diseases ; URI, asthma, pneumonia
3. not getting informed consent from the guardian

Primary outcomes:
measure: sucess rate of LMA insertion
timeFrame: 1 hour
Secondary outcomes:
measure: FOB(fiberoptic bronchoscope) grading of LMA position
timeFrame: 1 hour
Other outcomes:
Locations:
city: Seoul
country: Korea, Republic of
facility: Severance Hospital
Study officials:
References:
Clinical trial NCT06502275: Nutrition and Exercise Program for Elderly Colorectal Cancer Patients
Official title: Effects of the Tailored Frailty Prevention Program With Exercise and Nutrition Management to Improve Physical Performance and Health Status in Older Patients With Colorectal Cancer
Study type: INTERVENTIONAL
Overall status: RECRUITING
Phase: NA
Conditions: Colorectal Cancer
Keywords: Older
Colorectal cancer
Frailty
mobile health
Physical activity
nutrition
Lead sponsor: Chang Gung University of Science and Technology
Sponsor class: OTHER
First posted: 2024-07-16
Enrollment: 140
Sex: ALL
Minimum age (years): 60
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: HEALTH_SERVICES_RESEARCH

Brief summary: The goal of this interventional study is to evaluate the effect of mobile health intervention on frailty, physical fitness, physical activity, and nutritional status of elderly patients with colorectal cancer. The main questions it aim to answer are: 1. Does the mobile health intervention reduce frailty in elderly colorectal cancer patients compared to standard care? 2. Does the mobile health intervention improve physical fitness, physical activity, and nutritional status in elderly colorectal cancer patients compared to standard care? Participants will receive the Mobile Health Management Frailty Care Program.


Eligibility criteria: Inclusion Criteria:

* Patients diagnosed with colorectal cancer confirmed by a physician.
* Aged 60 and above.
* Have communication skills, able to read and write or converse in Mandarin and Taiwanese.
* Clear consciousness and no mental or cognitive impairment.
* Physical activities are accessible.
* Those who have a smartphone and have experience using smartphones.

Exclusion Criteria:

* People who have difficulty walking or standing.
* The wrist is not suitable for those wearing sports bracelets.
* People in infectious or protective isolation.
* Those who live alone or in institutions.

Primary outcomes:
measure: Frailty
timeFrame: Pre-test, sixth week after intervention, 13th week after intervention
measure: Physical Activity
timeFrame: Pre-test, sixth week after intervention, 13th week after intervention
measure: Nutritional Status
timeFrame: Pre-test, sixth week after intervention, 13th week after intervention
Secondary outcomes:
measure: health-related quality of life
timeFrame: Pre-test, sixth week after intervention, 13th week after intervention
measure: Depression
timeFrame: Pre-test, sixth week after intervention, 13th week after intervention
measure: body mass index
timeFrame: Pre-test, sixth week after intervention, 13th week after intervention
measure: hand grip strength
timeFrame: Pre-test, sixth week after intervention, 13th week after intervention
measure: walking speed
timeFrame: Pre-test, sixth week after intervention, 13th week after intervention
Other outcomes:
Locations:
city: Chiayi City
country: Taiwan
facility: Chang Gung Memorial Hospital
Study officials:
affiliation: Chang Gung University of Science and Technology
name: Ching-Ching Su, PhD
role: PRINCIPAL_INVESTIGATOR
References: