Clinical trial NCT01818453: Can Genetics Predict Treatment Response to a Computerized Self-help Program for Depression?
Official title: Genetic Predictors of Response to a Computerized Self-help Program for Depression
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Major Depressive Disorder
Mood Disorders
Keywords: Mood Disorders
Depression
Genetics
Treatment response
Treatment study
Lead sponsor: University of Texas at Austin
Sponsor class: OTHER
Collaborators: name: Brown University
First posted: 2013-03-26
Enrollment: 500
Sex: ALL
Minimum age (years): 18
Maximum age (years): 55
Standard ages: ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The goal of this project is to determine whether genetic information can be used to predict response to an internet-based treatment of depression. Several studies now indicate that completing an internet-based treatment for depression, called Deprexis, can significantly improve symptoms of depression. However, not everyone improves. The purpose of this study is to determine whether genetic profile can predict who is likely to improve.


Eligibility criteria: Inclusion Criteria:

* English-speaking
* Have reliable access to the internet (i.e., dialup or broadband access)
* Be willing to donate saliva for DNA research
* Have a current symptoms of depression
* Be stable on medication and/or therapy (i.e. no changes within 2 weeks of study entry)

Exclusion Criteria:

* Any diagnosis of a psychotic or bipolar disorder
* Meeting for alcohol/drug dependence in the past year
* Having current suicidal risk warranting crisis intervention

Primary outcomes:
measure: Quick Inventory of Depressive Symptomatology (Self-Report) (QIDS-SR-16)
timeFrame: Administred every 2 weeks while the participant is engaged in the online deprexis treatment program to measure depression symptom severity.
Secondary outcomes:
measure: Hamilton Depression Rating Scale (HAM-D)
timeFrame: The HAM-D will be completed during the pre- and post-treatment phone interviews to assess depression symptom severity.
measure: Inventory of Depression and Anxiety Symptoms (IDAS)
timeFrame: The IDAS will be completed as part of the pre- and post-treatment questionnaires to assess for symptoms of depression and anxiety.
measure: Psychiatric Diagnostic Screening Questionnaire (PDSQ)
timeFrame: The PDSQ will be completed as part of the pre- and post-treatment questionnaires to screen for the most common DSM-IV Axis I disorders..
measure: Risky Families Questionnaire (RFQ)
timeFrame: The RFQ will be completed as part of the pre-treatment questionnaires to assess early familial experiences and the harshness of family climate.
measure: Massachusetts General Hospital Antidepressant Treatment History Questionnaire (ATRQ)
timeFrame: The ATRQ will be administered as part of the pre-treatment questionnaires to evaluate psychotropic efficacy.
measure: Sheehan Disability Scale (SDS)
timeFrame: The SDS will be completed as part of the pre- and post-treatment questionnaires to evaluate symptom-related disability.
Other outcomes:
Locations:
city: Austin
country: United States
facility: The University of Texas at Austin
state: Texas
Study officials:
affiliation: The University of Texas at Austin
name: Christopher G Beevers, PhD
role: PRINCIPAL_INVESTIGATOR
References:
citation: Beevers CG, Pearson R, Hoffman JS, Foulser AA, Shumake J, Meyer B. Effectiveness of an internet intervention (Deprexis) for depression in a united states adult sample: A parallel-group pragmatic randomized controlled trial. J Consult Clin Psychol. 2017 Apr;85(4):367-380. doi: 10.1037/ccp0000171. Epub 2017 Feb 23.