Clinical trial NCT04979754: REnal TRansplant Outcomes After CARdiac Surgery (RETROCAR)
Official title: Long-term Renal Outcome After Cardiac Surgery : Impact of Previous Renal Transplantation
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Cardiac Surgery
Cardiopulmonary Bypass
Renal Transplant Recipient
Keywords: cardiac surgery
renal transplant recipient
renal function
acute kidney injury
major adverse kidney events
Lead sponsor: University Hospital, Bordeaux
Sponsor class: OTHER
First posted: 2021-07-28
Enrollment: 93
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: OTHER
Time perspective: RETROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Consecutive renal transplant récipients, apparied in a 1:2 ratio with non renal transplant récipients, undergoing cardiac surgery, and meeting the protocol criteria between january 2010 and december 2019, in university hospital of Bordeaux.

Brief summary: In this retrospective study, the authors assess long term renal outcome in renal transplant recipients after cardiac surgery with cardiopulmonary bypass, and research factors associated with poor long term renal outcome.

Detailed description: Post-operative mortality after cardiac surgery is increased in renal transplant recipients, compared with general population of cardiac surgery, or with kidney transplant recipients not undergoing cardiac surgery. If the survival of this specific population is now well studied, the long-term renal outcome is much less studied. Previous studies show a trend for increased risk of allograft dysfunction and need for permanent dialysis. This study proposes to compare long term renal outcome between renal transplant recipients and non-renal transplant recipients.

Eligibility criteria: Inclusion Criteria for Renal Transplant Recipients group:

* Previous renal transplantation
* Who underwent cardiac surgery with CPB

Inclusion Criteria for Non Renal Transplant Récipients group:

* No previous renal transplantation
* Who underwent cardiac surgery with CPB
* Apparied with Renal Transplant récipients with the 5 following criteria : age, sex, previous diagnosis of diabete, type of cardiac surgery (isolated coronary artery bypass graft, valvular surgery, aorta surgery, combined surgery), best glomerular filtration rate with CKD-EPI formula at +/- 15 ml/min, in the 3 pre-operative months

Exclusion Criteria:

* Patients requiring mechanical circulatory support (Extracorporeal Membrane Oxygenation)
* Pre-operative permanent dialysis
* Aorta dissection extended to renal arteries
* Non-elective surgery for infective endocarditis
* Previous hepatic, pancreatic or cardiac transplantation
* Death in the 30 first days after cardiac surgery
* Patient not meeting the inclusion criteria

Primary outcomes:
measure: Long-term renal outcome
timeFrame: 12 months after surgery
Secondary outcomes:
measure: Glomerular Filtration Rate (GFR)
timeFrame: 30 days after surgery
measure: Glomerular Filtration Rate (GFR)
timeFrame: 12 months after surgery
measure: Vital status
timeFrame: 12 months after surgery
measure: Major Adverse Kidney Events
timeFrame: Up to 12 months after surgery
Other outcomes:
Locations:
city: Pessac
country: France
facility: Bordeaux University Hospital
Study officials:
References: