Clinical trial NCT03882333: Effects of Acute Exercise on Pain and Human Movement
Official title: Effects of Acute Exercise on Pain and Human Movement - a Randomised Controlled Study in Patients With Chronic Pain and Healthy Controls
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Chronic Musculoskeletal Disease
Chronic Pain, Widespread
Keywords: Chronic musculoskeletal pain
Acute exercise
Movement control
Muscle activity
Lead sponsor: Dalarna University
Sponsor class: OTHER
Collaborators: name: Dalarna County Council, Sweden
name: Swedish Council for Working Life and Social Research
name: Karolinska Institutet
name: Swedish Armed Forces
First posted: 2019-03-20
Enrollment: 82
Sex: ALL
Minimum age (years): 18
Maximum age (years): 67
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Intervention model description: A randomised controlled study in patients with chronic pain and healthy controls
Primary purpose: TREATMENT

Brief summary: The aim of this research project is to evaluate the effect of an acute exercise intervention on pain intensity and movement control. It also aims to investigate potential differences in movement con-trol between patients with chronic musculoskeletal pain compared to healthy controls.

Detailed description: The aim of this research project is to evaluate the effect of an acute exercise intervention on pain intensity and movement control. It also aims to investigate potential differences in movement control between patients with chronic musculoskeletal pain compared to healthy controls. All tests will be conducted at Dalarna University.

After the initial baseline tests, participants will be randomised to either acute exercise intervention group or to a control group not performing any intervention groups (both patients and controls will be randomised to intervention or control). If randomised to the control group, participants rests corresponding to the time it takes to perform the intervention (30 min), and then preform the post-intervention tests similar as the intervention group.

Eligibility criteria: Inclusion Criteria:

Inclusion criteria for participants with chronic pain:

* Men and women, age 18-67 years,
* good ability to understand written and verbal information and instruction given in Swedish,
* chronic (\>3 months) musculoskeletal pain or chronic widespread pain.

Inclusion criteria for healthy controls:

* Men and women, age 18-67 years,
* good ability to understand written and verbal information and instruction given in Swedish.

Exclusion Criteria:

For participants with chronic pain

* chronic pain caused by malignancies or systemic diseases, other physical conditions that affects functional abilities and implies use of walking aid in-door,
* pregnancy after week 12, childbirth within the last 3 months or
* spinal surgery.

For healthy controls:

* chronic (\>3 months) or acute pain of any cause,
* other physical conditions that affects functional abilities, and implies use of walking aids in-door,
* pregnancy after week 12, childbirth in the last 3 months or
* spinal surgery.

Primary outcomes:
measure: Kinematic measures of human movement during functional gait sequences
timeFrame: 30 minutes (before and after the acute exercise intervention)
measure: Muscle activity
timeFrame: 30 minutes (before and after the acute exercise intervention)
Secondary outcomes:
measure: Self-rated pain using the Visual Analogue Scale (VAS scale).
timeFrame: 30 minutes (before and after the acute exercise intervention)
Other outcomes:
Locations:
city: Falun
country: Sweden
facility: Dalarna University (LIVI lab)
state: Dalarna
Study officials:
affiliation: Dalarna University
name: Björn BA Äng, Assoc. Prof.
role: PRINCIPAL_INVESTIGATOR
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