Clinical trial NCT04845451: The Presence and Role of Zygomatic-temporal Neuroma Triggering Cluster Headache
Official title: The Presence and Role of Zygomatic-temporal Neuroma Triggering Cluster Headache: Resection of a Neuroma in the Long-term Resolution of Trigeminal Cluster Symptoms
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Cluster Headache
Craniofacial Pain Syndrome
Keywords: cluster headache
neuralgic headache
Lead sponsor: Corona Doctors Medical Clinics, Inc.
Sponsor class: OTHER
Collaborators: name: Ohsi, Steven, M.D
name: Radfar, Amir, M.D
First posted: 2021-04-15
Enrollment: 5
Sex: ALL
Minimum age (years): 20
Maximum age (years): 70
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: CASE_ONLY
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: ٠patients suffering from episodic and chronic cluster headaches

Brief summary: Role of a neuroma of zygomatic-temporal in triggering of a cluster headache. Exploratory diagnosis, resection, and pathological examination of tumor anticipated

.

Detailed description: An anatomical coordinated communication of a Cluster Circuit turned on by Zygomatico-Temporal neuroma, a malicious possibly nontraumatic, neoplastic tissue coding and decoding itself upon autonomic release of neurotransmitter(s). Exhaustion of neurotransmitter synthesis turns out the explosions of pain-symptoms off.

Poor attention to the characterization of a peripheral neuroma of trigeminal nerve branch deranged attention to central(CNS) characterization of Cluster Symptoms.

This study based on our experimental results of minimal surgical procedure to explore, diagnose and resect a Zygomatico-Temporal neuroma in the temple of patients suffering from EpisodicChronic, Cluster Headache-ECCH. The goal is to light on this speculation in a novel analysis of events to put an end to devastating catastrophic headaches. Detailed anatomical components loci of the autonomic symptoms in the cluster headache reveal the presence of an electrical neural circuit.

The extracranial circuit components of ECCH reflects the anatomical nerve components participating reflection of the single circumscribed symptom:

1. Zygomatico-Temporal-neuroma
2. Zygomatic nerve V-II
3. Intraorbital communicants rami
4. Lacrimal nerve V-I
5. Ophthalmic nerve Intraorbital routing, supraorbital nerves, the upper eyelid, the conjunctiva and cornea of the eye, the nose (including the tip of the nose, except alae nasi), the nasal mucosa, the frontal sinuses. V-I
6. Optic nerve via ophthalmic nerve routing and electricity propagation.
7. Pterygopalatine ganglion as peripheral and CNS coordinator center.

An intracranial CNS reaction follows in response to the perception of pain materialized in neuroimaging during the activity of ECCH.

Eligibility criteria: Inclusion Criteria:

- Cluster headache

Exclusion Criteria:

* Malignant hypertension,
* Brain tumors,
* Cerebral vascular abnormalities,
* Presence of a brain or nerve electro stimulator.

Primary outcomes:
measure: Presence of Neuroma
timeFrame: 6 months
measure: Resolution of Cluster Headache attacks
timeFrame: 6 months
Secondary outcomes:
Other outcomes:
Locations:
city: Corona
country: United States
facility: Corona Doctors Medical Clinics Inc
state: California
Study officials:
affiliation: CORONA DOCTORS MEDICAL CLINICS
name: Faro T Owiesy, M.D.
role: PRINCIPAL_INVESTIGATOR
affiliation: Affiliated Patholgy
name: Steven Ohsie, M.D
role: STUDY_CHAIR
affiliation: Corona doctors medical clinics
name: Amir Radfar, M.D,MPH
role: STUDY_DIRECTOR
References: