Clinical trial NCT06343519: Echocardiographic and Laboratory Findings in Hemodynamic Monitoring of Shocked Patients
Official title: Comparison of Echocardiographic and Laboratory Findings in Hemodynamic Monitoring of Shocked Patients
Study type: OBSERVATIONAL
Overall status: NOT_YET_RECRUITING
Conditions: Shock
Lead sponsor: Assiut University
Sponsor class: OTHER
First posted: 2024-04-02
Enrollment: 60
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Observational model: CASE_ONLY
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Adult patients (age \>18 years) presenting with shock admitted to the intensive care unit.

Brief summary: Shocked patients require prompt and accurate assessment of their hemodynamic status to guide appropriate management. Echocardiography is a valuable tool for assessing cardiac function, while laboratory parameters such as mixed venous oxygen saturation and arterial blood lactate provide insights into tissue perfusion and oxygen metabolism. This study aims to compare echocardiographic findings, including cardiac index, speckle tracking parameters, and tissue Doppler indices, with laboratory findings in the evaluation of hemodynamic monitoring in shocked patients.

Detailed description: Shocked individuals necessitate expeditious and precise evaluation of their hemodynamic condition to direct appropriate treatment. The utilization of echocardiography is an invaluable method for appraising cardiac function, while the inclusion of laboratory parameters such as mixed venous oxygen saturation and arterial blood lactate offers valuable insights into tissue perfusion and oxygen metabolism. The primary objective of this study is to compare the echocardiographic discoveries, which encompass the assessment of cardiac index, speckle tracking parameters, and tissue Doppler indices, with the laboratory findings in the comprehensive assessment of hemodynamic monitoring in individuals experiencing shock. The purpose of this investigation is to delineate the correlation between echocardiographic and laboratory assessments in order to enhance our understanding of hemodynamic status in patients who are in a state of shock.

Eligibility criteria: Inclusion Criteria:

* Patients diagnosed with shock based on clinical criteria (e.g., hypotension, signs of tissue hypoperfusion) requiring hemodynamic monitoring.
* Patients age \> 18 year old.

Exclusion Criteria:

* Patients with pre-existing cardiac conditions affecting echocardiographic parameters, those receiving mechanical circulatory support.
* Patients with contraindications to echocardiography or blood sampling.

Primary outcomes:
measure: Change in Shock Status After Fluid Therapy Based on Echocardiographic Assessment of Fluid Responsiveness
timeFrame: 24 hours
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
affiliation: Assiut University
name: Dina Ahmed
role: STUDY_DIRECTOR
affiliation: Assiut University
name: Mohamed Maghraby
role: STUDY_CHAIR
References:
citation: Jardin F, Fourme T, Page B, Loubieres Y, Vieillard-Baron A, Beauchet A, Bourdarias JP. Persistent preload defect in severe sepsis despite fluid loading: A longitudinal echocardiographic study in patients with septic shock. Chest. 1999 Nov;116(5):1354-9. doi: 10.1378/chest.116.5.1354.