Clinical trial NCT06003413: Evaluation of the Relationship Between Muscle Architecture and Muscle Strength in Female Gonarthrosis Patients
Official title: Evaluation of the Relationship Between the Architecture of the Quadriceps, Tibialis Anterior and Gastrocnemius Muscles and Muscle Strength in Female Gonarthrosis Patients
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Osteo Arthritis Knee
Gonarthrosis
Osteoarthritis
Lead sponsor: Bezmialem Vakif University
Sponsor class: OTHER
First posted: 2023-08-22
Enrollment: 30
Sex: FEMALE
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Observational model: CASE_CONTROL
Time perspective: CROSS_SECTIONAL
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Patients who applied to the Bezmialem Vakıf University, Physical Medicine and Rehabilitation Outpatient Clinic appropriate for eligibility criteria will be enrolled

Brief summary: The goal of this cross-sectional study is to evaluate muscle architecture changes and it's effect on muscle strength in female patients with gonarthrosis.Main questions are:

* Is there any correlation between muscle strength and muscle thickness, pennation angle fiber length?
* Is there any muscle architecture difference in gonarthrosis and is it effecting the muscle strength? The investigators will enroll patients with unilateral gonarthrosis so that investigators can compare the changes within osteoarthritic and healthy knee with the same physical activity levels.

Detailed description: Knee osteoarthritis (OA) is a chronic disease characterized by morning stiffness, reduced joint range of motion, chronic pain, and decreased muscle strength, leading to functional limitations as the disease progresses . In patients with knee osteoarthritis, all muscles of the hip, knee, and ankle are affected in some way . Evidence suggests that impairments in muscle strength in the lower extremities contribute to increased pain and joint space narrowing. Voluntary muscle contractions lead to various changes in muscle architecture, including changes in fascicle angle and pennation angle as well as muscle thickness. While muscle cross-sectional area and thickness are primarily associated with the magnitude of generated force, parameters such as pennation angle have been found to be more related to explosive force. Ultrasonography (US) is a non-invasive imaging method that can visualize these changes. Muscle architecture parameters obtained from US can provide reliable data related to muscle contractility independently of surrounding muscles. Furthermore, US is considered to have similar validity to MRI imaging, which is the gold standard for displaying muscle architecture. Additionally, isometric muscle strength can be reliably measured using handheld dynamometers. Although studies have investigated the relationship between muscle strength and muscle architecture determined by US in patients with knee OA, these studies have predominantly examined the relationship in the quadriceps muscle, and muscles associated with the ankle have not been studied extensively.

Eligibility criteria: Inclusion Criteria:

* To be ≥18 years of age,
* Presence of unilateral knee OA (according to American College of Rheumatology criteria),
* Presence of knee OA with Kellgren/Lawrence (K/L) stage ≥2,
* Ability to live independently,
* Ability to walk without assistive devices.

Exclusion Criteria:

* History of surgery on the spine or lower extremities,
* History of inflammatory rheumatic disease,
* Severe cardiovascular disease,
* Neuromuscular disease affecting muscle strength,
* Individuals following a regular exercise program,
* Secondary osteoarthritis.

Primary outcomes:
measure: Numeric Rating Scale
timeFrame: 1 day
measure: The Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC)
timeFrame: 1 day
measure: Isometric Knee Extension Muscle Strength
timeFrame: 1 day
measure: Isometric Ankle Dorsiflexion Muscle Strength
timeFrame: 1 day
measure: Isometric Ankle Plantar Flexion Muscle Strength
timeFrame: 1 day
measure: Health Assessment Questionnaire (HAQ)
timeFrame: 1 day
measure: Outcome Measures in Rheumatology (OMERACT) ultrasound scores for knee osteoarthritis (OA)
timeFrame: 1 day
Secondary outcomes:
Other outcomes:
Locations:
city: Istanbul
country: Turkey
facility: Bezmialem Vakif University
state: Fatih
Study officials:
affiliation: Bezmialem Vakif University
name: Ozan Volkan Yurdakul, Assoc. Prof.
role: STUDY_DIRECTOR
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