Clinical trial NCT05011513: Evaluation of Protease Inhibition for COVID-19 in Standard-Risk Patients (EPIC-SR).
Official title: AN INTERVENTIONAL EFFICACY AND SAFETY, PHASE 2/3, DOUBLE-BLIND, 2 ARM STUDY TO INVESTIGATE ORALLY ADMINISTERED PF 07321332/RITONAVIR COMPARED WITH PLACEBO IN NONHOSPITALIZED SYMPTOMATIC ADULT PARTICIPANTS WITH COVID-19 WHO ARE AT LOW RISK OF PROGRESSING TO SEVERE ILLNESS
Study type: INTERVENTIONAL
Overall status: TERMINATED
Phase: PHASE2
PHASE3
Conditions: COVID-19
Keywords: SARS-CoV-2 Infection
Lead sponsor: Pfizer
Sponsor class: INDUSTRY
First posted: 2021-08-18
Enrollment: 1440
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Intervention model description: Eligible participants with a confirmed diagnosis of SARS-CoV-2 infection will be randomized (1:1) to receive PF-07321332/ritonavir or placebo orally every 12 hours for 5 days (10 doses total).
Primary purpose: TREATMENT

Brief summary: The primary hypothesis to be tested is whether or not there is a difference in time to sustained alleviation of all targeted COVID-19 signs and symptoms through Day 28 between PF-07321332/ritonavir and placebo.

Detailed description: Throughout the study period, provision will be made to allow study visits to be conducted at a participant's home or at another non-clinic location, if available. The total study duration is up to 24 weeks.

Eligibility criteria: Inclusion Criteria:

* Confirmed SARS-CoV-2 infection 5 days prior to randomization
* Initial onset of COVID-19 signs/symptoms within 5 days of randomization
* Fertile participants must agree to use a highly effective method of contraception

Exclusion Criteria:

* Has at least one underlying medical condition associated with an increased risk of developing severe illness from COVID-19
* History of or need for hospitalization for the medical treatment of COVID-19
* Prior diagnosis of SARS-CoV-2 infection (reinfection)
* Known medical history of liver disease
* Receiving dialysis or have known renal impairment
* Known Human Immunodeficiency Virus (HIV) infection with viral load \> 400 copies/ml or taking prohibited medications for HIV treatment
* Suspected or confirmed concurrent active systemic infection other than COVID-19
* Current or expected use of any medications or substances that are highly dependent on Cytochrome P450 3A4 (CYP3A4) for clearance or are strong inducers of CYP3A4
* Has received or is expected to receive monoclonal antibody treatment or convalescent COVID-19 plasma
* Has received any SARS-CoV-2 vaccine within 12 months of screening
* Participating in another interventional clinical study with an investigational compound or device, including those for COVID-19
* Known prior participation in this trial or other trial involving PF-07321332
* Oxygen saturation of \< 92% on room air
* Females who are pregnant or breastfeeding

Primary outcomes:
measure: Time to Sustained Alleviation of Overall COVID-19 Signs and Symptoms Through Day 28
timeFrame: From Day 1 to Day 28
Secondary outcomes:
measure: Number of Participants With Treatment Emergent Adverse Events (TEAEs), Serious AEs and AEs Leading to Study and Study Drug Discontinuation
timeFrame: From start of study intervention (Day 1) up to Day 34
measure: Percentage of Participants With COVID-19 Related Hospitalization or Death From Any Cause Through Day 28
timeFrame: From Day 1 to Day 28
measure: Percentage of Participants With Death Through Week 24
timeFrame: From Day 1 to Week 24
measure: Number of COVID-19 Related Medical Visits Per Day Through Day 28
timeFrame: From Day 1 to Day 28
measure: Duration of Hospitalization and Intensive Care Unit (ICU) Stay Through Day 28
timeFrame: From Day 1 to Day 28
measure: Percentage of Participants With Severe Signs and Symptoms of COVID-19 Through Day 28
timeFrame: From Day 1 to Day 28
measure: Time to Sustained Resolution of Overall COVID-19 Signs and Symptoms Through Day 28
timeFrame: From Day 1 to Day 28
measure: Time to Sustained Alleviation of Each COVID-19 Signs and Symptoms Through Day 28
timeFrame: From Day 1 to Day 28
measure: Time to Sustained Resolution of Each COVID-19 Signs and Symptoms Through Day 28
timeFrame: From Day 1 to Day 28
measure: Percentage of Participants With Progression to Worsening Status of COVID-19 Signs and Symptoms
timeFrame: From Day 1 to Day 28
measure: Percentage of Participants With Resting Peripheral Oxygen Saturation Greater Than or Equal to (>=) 95% at Day 1 and Day 5
timeFrame: Day 1 and Day 5
measure: Plasma Concentration Versus Time Summary of PF-07321332
timeFrame: Day 1: 1 hour post dose; Day 5: 0 minutes pre-dose
measure: Change From Baseline in Logarithm to Base10 (Log10) Transformed Viral Load at Days 3, 5, 10 and 14
timeFrame: Baseline, Days 3, 5, 10 and 14
Other outcomes:
Locations:
city: Pelham
country: United States
facility: Cahaba Research Inc
state: Alabama
city: Mesa
country: United States
facility: The Institute for Liver Health dba Arizona Clinical Trials
state: Arizona
city: Scottsdale
country: United States
facility: Matrix Mobile Health Clinic #49, #35, and #62
state: Arizona
city: Tucson
country: United States
facility: The Institute for Liver Health dba Arizona Clinical Trials
state: Arizona
city: Canoga Park
country: United States
facility: Hope Clinical Research
state: California
city: El Segundo
country: United States
facility: Lightship
state: California
city: Fullerton
country: United States
facility: Ascada Research
state: California
city: La Palma
country: United States
facility: Atella Clinical Research LLC.
state: California
city: Long Beach
country: United States
facility: Ark Clinical Research
state: California
city: Redondo Beach
country: United States
facility: South Bay Clinical Research Institute
state: California
city: Sacramento
country: United States
facility: Benchmark Research
state: California
city: San Francisco
country: United States
facility: Optimus Medical Group
state: California
city: West Hills
country: United States
facility: Hope Clinical Research (COVID Satellite Site)
state: California
city: Colorado Springs
country: United States
facility: Future Innovative Treatments, LLC
state: Colorado
city: Bradenton
country: United States
facility: Synergy Healthcare
state: Florida
city: Brandon
country: United States
facility: MOORE Clinical Research, Inc.
state: Florida
city: Brandon
country: United States
facility: TrueBlue Clinical Research
state: Florida
city: Coral Gables
country: United States
facility: Herco Medical and Research Center Inc
state: Florida
city: Cutler Bay
country: United States
facility: Advance Clinical Research Group
state: Florida
city: Cutler Bay
country: United States
facility: Beautiful Minds Clinical Research Center
state: Florida
city: DeBary
country: United States
facility: Omega Research Orlando, LLC
state: Florida
city: Hialeah Gardens
country: United States
facility: Unlimited Medical Research Group, LLC
state: Florida
city: Hialeah
country: United States
facility: Eastern Research Inc
state: Florida
city: Hialeah
country: United States
facility: Inpatient Research Clinic
state: Florida
city: Hialeah
country: United States
facility: Doral Medical Research, LLC
state: Florida
city: Lutz
country: United States
facility: ASCLEPES Research Centers
state: Florida
city: Miami Gardens
country: United States
facility: Pro-Care Research Center, Corp.
state: Florida
city: Miami Lakes
country: United States
facility: Savin Medical Group, LLC
state: Florida
city: Miami
country: United States
facility: Angels Clinical Research Institute
state: Florida
city: Miami
country: United States
facility: LCC Medical Research Institute, LLC
state: Florida
city: Miami
country: United States
facility: Premium Medical Research Corp
state: Florida
city: Miami
country: United States
facility: Global Health Clinical Trials Corp
state: Florida
city: Miami
country: United States
facility: South Florida Research Center, Inc.
state: Florida
city: Miami
country: United States
facility: I.V.A.M. Clinical & Investigational Center, LLC
state: Florida
city: Miami
country: United States
facility: C'A Research
state: Florida
city: Miami
country: United States
facility: ProLive Medical Research, Corp.
state: Florida
city: Miami
country: United States
facility: Entrust Clinical Research
state: Florida
city: Miami
country: United States
facility: Reed Medical Research
state: Florida
city: Miami
country: United States
facility: Kendall South Medical Center, Inc.
state: Florida
city: Miami
country: United States
facility: Clinical Site Partners, Inc d/b/a CSP Miami
state: Florida
city: Miami
country: United States
facility: Coral Research Clinic Corp
state: Florida
city: Orlando
country: United States
facility: Omega Research Orlando, LLC
state: Florida
city: Port Saint Lucie
country: United States
facility: CDC Research Institute
state: Florida
city: Saint Petersburg
country: United States
facility: GCP, Global Clinical Professionals
state: Florida
city: South Miami
country: United States
facility: USPA Advance Concept Medical Research Group LLC
state: Florida
city: Spring Hill
country: United States
facility: ASCLEPES Research Centers
state: Florida
city: Sunrise
country: United States
facility: Sunrise Research Institute
state: Florida
city: Tampa
country: United States
facility: Santos Research Center, CORP
state: Florida
city: Winter Park
country: United States
facility: Clinical Site Partners, Inc. dba CSP Orlando
state: Florida
city: Ames
country: United States
facility: Accellacare
state: Iowa
city: Ames
country: United States
facility: McFarland Clinic, PC
state: Iowa
city: Marrero
country: United States
facility: New Orleans Sinus Center (COVID-19 Testing)
state: Louisiana
city: Marrero
country: United States
facility: Tandem Clinical Research GI, LLC
state: Louisiana
city: Metairie
country: United States
facility: Southern Clinical Research Associates, LLC
state: Louisiana
city: Butte
country: United States
facility: Mercury Street Medical Group, PLLC
state: Montana
city: Las Vegas
country: United States
facility: Excel Clinical research
state: Nevada
city: Santa Fe
country: United States
facility: AXCES Research Group
state: New Mexico
city: New York
country: United States
facility: NYC Health + Hospitals / Harlem
state: New York
city: Monroe
country: United States
facility: Monroe Biomedical Research
state: North Carolina
city: Wilmington
country: United States
facility: Accellacare
state: North Carolina
city: Wilmington
country: United States
facility: Innovo Research: Wilmington Health
state: North Carolina
city: Sioux Falls
country: United States
facility: Avera McKennan Hospital & University Health Center
state: South Dakota
city: Sioux Falls
country: United States
facility: Avera Research Institute
state: South Dakota
city: Amarillo
country: United States
facility: PharmaTex Research, LLC
state: Texas
city: Austin
country: United States
facility: ARC Clinical Research at William Cannon
state: Texas
city: Bellaire
country: United States
facility: St Hope Foundation
state: Texas
city: Conroe
country: United States
facility: Conroe Willis Medical Research
state: Texas
city: Corpus Christi
country: United States
facility: South Texas Clinical Research
state: Texas
city: Houston
country: United States
facility: SignatureCare Emergency Center
state: Texas
city: Houston
country: United States
facility: Trio Clinical Trials, LLC
state: Texas
city: Houston
country: United States
facility: Next Level Urgent Care
state: Texas
city: Pearland
country: United States
facility: LinQ Research, LLC
state: Texas
city: Red Oak
country: United States
facility: Epic Medical Research
state: Texas
city: San Antonio
country: United States
facility: Endeavor Clinical Trials, LLC
state: Texas
city: San Antonio
country: United States
facility: BFHC Research
state: Texas
city: Webster
country: United States
facility: Tranquility Research
state: Texas
city: Newport News
country: United States
facility: TMPG Clinical Research
state: Virginia
city: Newport News
country: United States
facility: TPMG Clinical Research
state: Virginia
city: Zarate
country: Argentina
facility: Instituto de Investigaciones Clinicas Zarate
state: Buenos Aires
city: Rosario
country: Argentina
facility: Instituto Médico de la Fundación Estudios Clínicos (Fundación Estudios Clínicos)
state: Santa FE
city: San Miguel de Tucuman
country: Argentina
facility: Hospital de Clinicas Presidente Nicolas Avellaneda
state: Tucuman
city: San Miguel de Tucuman
country: Argentina
facility: Clinica Mayo Urgencias Medicas Cruz Blanca SRL
state: Tucuman
city: Córdoba
country: Argentina
facility: Hospital Privado Centro Médico de Córdoba
city: Brasilia
country: Brazil
facility: Chronos Pesquisa Clinica
state: Distrito Federal
city: Recife
country: Brazil
facility: Hospital Agamenon Magalhaes
state: Pernambuco
city: Natal
country: Brazil
facility: Centro de Estudos e Pesquisas em Moléstias Infecciosas
state: RIO Grande DO Norte
city: Porto Alegre
country: Brazil
facility: Hospital De Clinicas De Porto Alegre
state: RIO Grande DO SUL
city: Rio de Janeiro
country: Brazil
facility: IBPClin - Instituto Brasil de Pesquisa Clínica
state: RJ
city: Rio de Janeiro
country: Brazil
facility: Instituto Nacional de Infectologia Evandro Chagas - INI/FIOCRUZ
state: RJ
city: Boa Vista
country: Brazil
facility: CECOR - Centro Oncológico de Roraima
state: Roraima/rr
city: Jau
country: Brazil
facility: CECIP JAÚ - Centro de Estudos Clínicos do Interior Paulista - LTDA
state: SAO Paulo
city: Blumenau
country: Brazil
facility: Hospital Dia do Pulmao
state: SC
city: Campinas
country: Brazil
facility: Hospital e Maternidade Celso Pierro - PUC Campinas / Sociedade Campineira de Educação e Instruçã
state: SP
city: São Paulo
country: Brazil
facility: Hospital Alemão Oswaldo Cruz
state: SP
city: São Paulo
country: Brazil
facility: Unidade Referenciada Oswaldo Cruz Vergueiro
state: SP
city: Sorocaba
country: Brazil
facility: Clinica de Alergia Martti Antila
state: SÃO Paulo
city: São Bernardo do Campo
country: Brazil
facility: CEMEC - Centro Multidisciplinar de Estudos Clínicos
state: SÃO Paulo
city: São Paulo
country: Brazil
facility: Instituto de Infectologia Emilio Ribas
city: Burgas
country: Bulgaria
facility: Individual Practice for Primary Medical Care - IPPMC - Dr. P. Panayotov EOOD
city: Haskovo
country: Bulgaria
facility: "Specialized Hospital for Active Treatment of Pneumo-Phthisiatric Diseases-Haskovo" Ltd
city: Kozloduy
country: Bulgaria
facility: MHAT "Sv.Ivan. Rilski'' Kozloduy EOOD
city: Lom
country: Bulgaria
facility: Diagnostic-Consultative Center I Lom EOOD
city: Lom
country: Bulgaria
facility: Multiprofile Hospital for Active Treatment- Sveti Nikolay Chudotvoretz EOOD
city: Lovech
country: Bulgaria
facility: Medical centre Leo Clinic EOOD
city: Pleven
country: Bulgaria
facility: MHAT Heart and Brain EAD
city: Plovdiv
country: Bulgaria
facility: DCC Sveti Georgi EOOD
city: Plovdiv
country: Bulgaria
facility: MHAT "St. Panteleimon "- Plovdiv
city: Razgrad
country: Bulgaria
facility: Multiprofile Hospital for Active Treatment Sveti Ivan Rilski - Razgrad AD
city: Ruse
country: Bulgaria
facility: "Specialized Hospital for Active Treatment of Pneumo-Physiatric Diseases Dr. Dimitar Gramatikov -
city: Samokov
country: Bulgaria
facility: Multiprofile Hospital for Active Treatment - Samokov EOOD
city: Sevlievo
country: Bulgaria
facility: Medical Center-1-Sevlievo EOOD
city: Sliven
country: Bulgaria
facility: Multiprofile hospital for active treatment - Sliven to Military Medical Academy
city: Sofia
country: Bulgaria
facility: Diagnostic-Consultative Center XXII- Sofia ЕООD
city: Sofia
country: Bulgaria
facility: UMHATEM N. I. Pirogov EAD
city: Sofia
country: Bulgaria
facility: MHAT "St. Sofia" EOOD
city: Stara Zagora
country: Bulgaria
facility: Specialized hospital for active treatment in pulmonology and phthisiology "Stara Zagora" EOOD
city: Targovishte
country: Bulgaria
facility: Multiprofile Hospital for Active Treatment Targovishte AD
city: Tsarevo
country: Bulgaria
facility: Outpatient Clinic for Primary Outpatient Medical Care "Puls" - Dr. Mladen Buchvarov EOOD
city: Varna
country: Bulgaria
facility: Medical center Leo Clinic EOOD
city: Veliko Tarnovo
country: Bulgaria
facility: MOBAL "D-r Stefan Cherkezov" AD
city: Vratsa
country: Bulgaria
facility: Specialized Hospital for Active Treatment of Pneumo-Phthisiatric Diseases Vratsa EOOD
city: Medellin
country: Colombia
facility: Fundacion Centro de Investigacion Clinica CIC
state: Antioquia
city: Bogota
country: Colombia
facility: Centro de Investigacion en Reumatologia y Especialidades Medicas S.A.S, CIREEM S.A.S
state: Cundinamarca
city: Armenia
country: Colombia
facility: Fundacion Cardiomet Cequin
state: Quindio
city: Protivín
country: Czechia
facility: Zdraví-Fit, s.r.o.
city: Slany
country: Czechia
facility: Nemocnice Slany
city: Bekescsaba
country: Hungary
facility: Trial Pharma Kft.
city: Budapest
country: Hungary
facility: Semmelweis University Varosmajori Sziv Es Ergyogyaszati Klinika
city: Budapest
country: Hungary
facility: Varosmajori Sziv- es Ergyogyaszati Klinika
city: Debrecen
country: Hungary
facility: Debreceni Egyetem Klinikai Kozpont Infektologiai Klinika
city: Eger
country: Hungary
facility: Agria-Study Kft.
city: Gyula
country: Hungary
facility: Trial Pharma Kft.
city: Nyiregyhaza
country: Hungary
facility: Medifarma-98 Kft.
city: Narita
country: Japan
facility: International University of Health and Welfare Narita Hospital
state: Chiba
city: Kyoto-shi
country: Japan
facility: Rakuwakai Otowa Hospital
state: Kyoto
city: Shinagawa-ku
country: Japan
facility: Tokyo Shinagawa Hospital
state: Tokyo
city: Toshimaku
country: Japan
facility: Sekino Hospital
state: Tokyo
city: Fukuoka
country: Japan
facility: Kyushu Medical Center
city: Gwangju
country: Korea, Republic of
facility: Chonnam National University Bitgoeul Hospital
city: Seoul
country: Korea, Republic of
facility: Boramae Medical Center
city: Seoul
country: Korea, Republic of
facility: SMG-SNU Boramae Medical Center
city: Kota Bharu
country: Malaysia
facility: Hospital Raja Perempuan Zainab II
state: Kelantan
city: Taiping
country: Malaysia
facility: Hospital Taiping
state: Perak
city: Miri
country: Malaysia
facility: Hospital Miri
state: Sarawak
city: Rawang
country: Malaysia
facility: Klinik Kesihatan Kuang
state: Selangor
city: Saltillo
country: Mexico
facility: Clinical Research Institute S.C.
state: Coahuila
city: Pachuca de Soto
country: Mexico
facility: Asociación Mexicana para la Investigación Clínica A.C.
state: Hidalgo
city: Cuernavaca
country: Mexico
facility: JM Research SC
state: Morelos
city: Monterrey
country: Mexico
facility: Christus - Latam Hub Center of Excellence and Innovation Center S.C.
state: Nuevo LEON
city: Monterrey
country: Mexico
facility: Eukarya Pharmasite S.C.
state: Nuevo LEON
city: Oaxaca de Juarez
country: Mexico
facility: Oaxaca Site Management Organization
state: Oaxaca
city: Merida
country: Mexico
facility: Kohler & Milstein Research S.A. De C.V.
state: Yucatan
city: Mérida
country: Mexico
facility: EME RED Hospitalaria
state: Yucatán
city: Durango
country: Mexico
facility: Instituto de Investigaciones Clínicas para la Salud
city: Veracruz
country: Mexico
facility: FAICIC Clinical Research
city: Veracruz
country: Mexico
facility: Sociedad de Metabolismo y Corazon S.C.
city: Bialystok
country: Poland
facility: KLIMED Marek Klimkiewicz
city: Swidnik
country: Poland
facility: Tomasz Blicharski Lubelskie Centrum Diagnostyczne
city: Warszawa
country: Poland
facility: WIP Warsaw IBD Point Profesor Kierkus
city: Wroclaw
country: Poland
facility: Centrum Badań Klinicznych Piotr Napora Lekarze Spółka Partnerska
city: Ponce
country: Puerto Rico
facility: Clinical Research Management Group Inc
city: San Juan
country: Puerto Rico
facility: Advance Medical Research Center
city: Bucuresti
country: Romania
facility: Delta Health Care srl
city: Moldava nad Bodvou
country: Slovakia
facility: HODOSI - MED, s.r.o.
city: Pruske
country: Slovakia
facility: MUDr. Viliam Cibik, PhD., s.r.o.
city: Spisska Nova Ves
country: Slovakia
facility: Plucna ambulancia Hrebenar, s.r.o.
city: Topolcany
country: Slovakia
facility: ALERGIA s.r.o.
city: Gqeberha
country: South Africa
facility: Global Clinical Trials
state: Eastern CAPE
city: Benoni
country: South Africa
facility: Worthwhile Clinical Trials
state: Gauteng
city: Boksburg
country: South Africa
facility: Reimed Vosloorus
state: Gauteng
city: Johannesburg
country: South Africa
facility: Lenasia Clinical Trial Centre
state: Gauteng
city: Pretoria
country: South Africa
facility: Botho Ke Bontle Health Services
state: Gauteng
city: Pretoria
country: South Africa
facility: Clinical Trial Systems (Pty) Ltd
state: Gauteng
city: Sandton
country: South Africa
facility: Sandton Medical Clinic
state: Gauteng
city: Vereeniging
country: South Africa
facility: FCRN Clinical Trial Centre
state: Gauteng
city: Durban
country: South Africa
facility: Dr PJ Sebastian Clinical Research Centre
state: Kwa-zulu Natal
city: Durban
country: South Africa
facility: Synapta Clinical Research Center
state: Kwazulu Natal
city: Mayville, Durban
country: South Africa
facility: Ahmed Al-Kadi Private Hospital
state: Kwazulu-natal
city: George
country: South Africa
facility: TASK Eden
state: Western CAPE
city: Paarl
country: South Africa
facility: Be Part Research Pty (Ltd)
state: Western CAPE
city: Centelles
country: Spain
facility: Eba Centelles
state: Barcelona [barcelona]
city: Badalona
country: Spain
facility: Hospital Universitari Germans Trias i Pujol
state: Barcelona
city: Vigo
country: Spain
facility: Hospital Alvaro Cunqueiro
state: Pontevedra
city: Burjassot
country: Spain
facility: IMED Valencia
state: Valencia
city: A Coruna
country: Spain
facility: Complexo Hospitalario Universitario da Coruna
city: A Coruña
country: Spain
facility: Complexo Hospitalario Universitario da Coruna
city: Madrid
country: Spain
facility: Hospital Universitario de la Paz
city: Sevilla
country: Spain
facility: Hospital Universitario Virgen de Valme
city: BangkokNoi
country: Thailand
facility: Siriraj Hospital, Mahidol University
state: Bangkok
city: Bangplud
country: Thailand
facility: Riverside Bangkok Hotel
state: Bangkok
city: Bangrak
country: Thailand
facility: Bangkok Centre Hotel
state: Bangkok
city: Pathumwan,
country: Thailand
facility: Thai Red Cross Emerging Infectious Diseases (EDI) Clinic
state: Bangkok
city: Pathumwan
country: Thailand
facility: The HIV Netherlands Australia Thailand Research Collaboration (HIV-NAT),
state: Bangkok
city: Ratchathewi
country: Thailand
facility: Baiyoke Suite Hotel
state: Bangkok
city: Hat Yai
country: Thailand
facility: Department of Internal Medicine, Faculty of Medicine, Prince of Songkla University,
state: Songkhla
city: Khon Kaen
country: Thailand
facility: Khon Kaen Univerisity Field Hospital, Student Dormitory 26, Khon Kaen University
city: Khon Kaen
country: Thailand
facility: Srinagarind Hospital
city: Balcali
country: Turkey
facility: Cukurova University Medical Faculty
state: Adana
city: Ankara
country: Turkey
facility: Ankara University Medical Faculty, Ibni-Sina Hospital
city: Ankara
country: Turkey
facility: Hacettepe University Medical Faculty Hospital
city: Antalya
country: Turkey
facility: Akdeniz Universitesi Hastanesi
city: Gaziantep
country: Turkey
facility: Gaziantep Universitesi Tip Fakultesi Sahinbey Uygulama ve Arastirma Hastanesi
city: Istanbul
country: Turkey
facility: Istanbul University Istanbul Medical Faculty
city: Istanbul
country: Turkey
facility: Istanbul University Cerrahpasa-Cerrahpasa Medical Faculty
city: Istanbul
country: Turkey
facility: Medipol Mega University Hospital
city: Istanbul
country: Turkey
facility: Acibadem University Atakent Hospital
city: Istanbul
country: Turkey
facility: Basaksehir Cam ve Sakura Sehir Hastanesi
city: Izmir
country: Turkey
facility: Izmir Suat Seren Chest Disease and Surgery Training and Research Hospital
city: Kocaeli
country: Turkey
facility: Kocaeli University Medical Faculty
city: Mersin
country: Turkey
facility: Mersin University Medical Faculty
city: Sakarya
country: Turkey
facility: Sakarya University Training and Research Hospital
city: Trabzon
country: Turkey
facility: Karadeniz Teknik Universitesi Farabi Hastanesi
city: Chernivtsi
country: Ukraine
facility: Regional Communal Nonprofit Institution "Chernivtsi Regional Clinical Hospital"
city: Chernivtsi
country: Ukraine
facility: Communal non-commercial Enterprise "City Clinical Hospital №3" of Chernivtsi City Council
city: Ivano-Frankivsk
country: Ukraine
facility: Municipal Nonprofit Enterprise "Ivano-Frankivsk Regional Clinical Infectious Diseases Hospital of
city: Ivano-Frankivsk
country: Ukraine
facility: Municipal Non-profit Enterprise "Ivano-Frankivsk Regional Phthisiopulmonology Center of
city: Ivano-Frankivsk
country: Ukraine
facility: Communal nonprofit enterprise "Central City Clinical Hospital of Ivano-Frankivsk City Council"
city: Kharkiv
country: Ukraine
facility: Municipal Nonprofit Enterprise of Kharkiv Regional Council "Regional Clinical Infectious Diseases
city: Kyiv
country: Ukraine
facility: Municipal Non-profit Enterprise "Oleksandrivska Kyiv City Clinical Hospital" Of Executive Body Of
city: Kyiv
country: Ukraine
facility: Municipal non-commercial enterprise "Kyiv City Clinical Hospital #1" Of Executive Body Of the Kyiv
city: Kyiv
country: Ukraine
facility: Kyiv Railway Clinical Hospital No.2 of Branch "Health Center of the Public Joint Stock Company
city: Kyiv
country: Ukraine
facility: Polyclinic of Center for Medical Services and Rehabilitation of State Joint-Stock Holding Company
city: Lviv
country: Ukraine
facility: Municipal Nonprofit Enterprise "Lviv City Clinic Hospital #4"
city: Poltava
country: Ukraine
facility: Municipal Enterprise "Poltava Regional Clinical Infectious Diseases Hospital" of Poltava Regional
city: Vinnytsia
country: Ukraine
facility: Municipal Non-commercial Enterprise "Vinnytsia City Clinical Hospital №1"
city: Zhytomyr
country: Ukraine
facility: Communal Enterprise "Hospital #1" of Zhytomyr City Council
Study officials:
affiliation: Pfizer
name: Pfizer CT.gov Call Center
role: STUDY_DIRECTOR
References: