Clinical trial NCT02682706: Magnetic Resonance Imaging of Human Supraclavicular Brown Adipose Tissue - MIBAT Study
Official title: Magnetic Resonance Imaging of Human Supraclavicular Brown Adipose Tissue - MIBAT Study
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Healthy
Keywords: brown adipose tissue
magnetic resonance imaging
energy expenditure
non-shivering thermogenesis
Lead sponsor: University Hospital, Basel, Switzerland
Sponsor class: OTHER
First posted: 2016-02-15
Enrollment: 26
Sex: ALL
Minimum age (years): 18
Maximum age (years): 50
Standard ages: ADULT
Accepts healthy volunteers: yes
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: healthy volunteers

Brief summary: Brown adipose tissue (BAT) is unique in its capability to convert chemical energy directly into heat. Active BAT increases energy expenditure and can thereby counteract obesity and insulin resistance. Currently, the imaging method of choice to assess BAT morphology and function is 18F-FDG-PET/CT which is expensive and exposes patients or healthy volunteers to ionizing radiation, thus impeding larger prospective studies.

Magnetic resonance imaging (MRI) could constitute a suitable alternative and preliminary small-scale studies are promising.

The overall aim of this research proposal is to develop reliable magnetic resonance imaging techniques to facilitate the study of brown adipose tissue in human adults, specifically in the context of endocrine disease.

Specifically, investigators want to

1. Develop a reliable MR imaging protocol for human BAT and compare BAT volume to cold induced nonshivering thermogenesis as a measure of BAT activity.
2. Assess the intra-individual variance of BAT volume measured by MRI.
3. Evaluate direct measurement of BAT temperature by functional MRI.


Eligibility criteria: Inclusion Criteria:

* Healthy volunteers
* Age 18-40 years
* Body mass index (BMI): 17.5-27 kg/m²

Exclusion Criteria:

* known concomitant disease influencing thyroid hormone metabolism
* severe diseases: chronic heart failure, liver cirrhosis, kidney failure, active cancer
* known hypersensitivity to cold, e.g. primary or secondary Raynaud's syndrome
* abuse of alcohol or illicit drugs
* Women who are pregnant or breast feeding
* Inability to follow the procedures of the study, e.g. due to language problems, psychological disorders, dementia, etc. of the participant
* Previous enrolment into the current study
* implanted device not compatible with MRI, e.g. pace maker

Primary outcomes:
measure: Correlation of scBAT volume and cold induced thermogenesis as determined by indirect calorimetry
timeFrame: both measurements within 2 weeks
Secondary outcomes:
Other outcomes:
Locations:
city: Basel
country: Switzerland
facility: University Hospital Basel, Department of Endocrinology
state: BS
city: Basel
country: Switzerland
facility: University Hospital of Basel, Department of Radiology
state: BS
Study officials:
affiliation: University Hospital, Basel, Switzerland
name: Matthias J Betz, MD
role: PRINCIPAL_INVESTIGATOR
References:
citation: Senn JR, Maushart CI, Gashi G, Michel R, Lalive d'Epinay M, Vogt R, Becker AS, Muller J, Balaz M, Wolfrum C, Burger IA, Betz MJ. Outdoor Temperature Influences Cold Induced Thermogenesis in Humans. Front Physiol. 2018 Aug 23;9:1184. doi: 10.3389/fphys.2018.01184. eCollection 2018.