Clinical trial NCT03946254: Effect of Strength Training on Executive Functions in Elderly People With Mild Cognitive Impairment
Official title: Effect of Strength Training on Executive Functions in Elderly People With Mild Cognitive Impairment
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Strength Training
Executive Function
Lead sponsor: University of Seville
Sponsor class: OTHER
First posted: 2019-05-10
Enrollment: 40
Sex: ALL
Minimum age (years): 60
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: PREVENTION

Brief summary: Cognitive impairment or dementia is their last degree in one of the main concerns at a social level in these ages. To this day, there are different pharmacological and non-pharmacological therapies that can help prevent deterioration, as in this case, physical exercise.

In the existing scientific literature, you can find a lot of information about the effect of aerobic exercise on cognition, but little is known about the effect of force exercise and its effect on general cognition and executive functions.

Therefore, in this research the investigators will investigate the effect of strength training in people over 60 with a diagnosis of mild cognitive impairment in executive functions. For this, a controlled and randomized clinical trial will be developed in the city of Seville

Detailed description: The training program will last 20 weeks and a frequency of 3 times / week.

During the week 0 the initial evaluation will be developed. Between weeks 1-20, the training program will be addressed. In week 21, all the changes made in all the measured variables will be evaluated.

Finally, in week 33 the variables will be measured again to see if the possible improvements given in the training program last over time.

The experimental group will perform a planned and individualized training with guided machines and training loads will be adjusted at the beginning of each week.

The control group will perform breathing and relaxation exercises to avoid a sample death.

After the intervention, there will be a follow-up phase for 3 months.

Eligibility criteria: Inclusion Criteria:

* The sample is made up of people over 60 years of age, who are not active professionally, speak and understand the Spanish language.
* In addition, they should be diagnosed with mild cognitive impairment. This will be evaluated by specialists through the minimental test (score between 24 and 28).
* On the other hand, they should not suffer from other serious psychiatric or neurodegenerative neurological diseases.
* In relation to mental health, it will be a reason for exclusion to have had 3 episodes of depression in the last 5 years or 10 episodes that have required some psychiatric or medical treatment.In addition,
* The people included must be postmenopausal

Exclusion Criteria:

* Participate in other physical exercise programs in a systematic way or in individualized and systematic programs in cognitive programs.
* Dispose of cardiovascular diseases, heart diseases that involve an absolute contradiction of physical exercise (unstable angina, severe auroventricular block) and cerebrovascular or have suffered a heart attack in the last 6 years.
* Have had seizures (More than 2 in the last 12 months).
* Consumption of alcohol 20 grams / day or 2 beers or wine glasses daily.
* Functional limitations (According to Functional activities Questionnaire)
* Being a musician or bilingual.

Primary outcomes:
measure: Baseline of Inhibitory control
timeFrame: week 0
measure: Mean Change from Baseline in Inhibitory control
timeFrame: week 21
measure: Inhibitory control in the follow-up phase
timeFrame: week 33
Secondary outcomes:
measure: Baseline of general cognition
timeFrame: Week 0
measure: Mean Change from Baseline in General cognition
timeFrame: week 21
measure: General cognition in the follow-up phase
timeFrame: week 33
measure: Baseline of physical condition
timeFrame: week 0
measure: Mean Change from Baseline in Physical condition
timeFrame: week 21
measure: Physical condition in the follow-up phase
timeFrame: week 33
measure: Baseline of physical condition variante
timeFrame: week 0
measure: Mean Change from Baseline in Physical condition variante
timeFrame: week 21
measure: Physical condition variante in the follow-up phase
timeFrame: week 33
measure: Baseline of blood test
timeFrame: week 0
measure: Mean Change from Baseline in Blood test
timeFrame: week 21
measure: Baseline of strength
timeFrame: week 0
measure: Mean Change from Baseline in Strength
timeFrame: week 21
measure: Strength in the follow-up phase
timeFrame: week 33
measure: Baseline of cognitive flexibility
timeFrame: week 0
measure: Mean Change from Baseline in cognitive flexibility
timeFrame: week 21
measure: cognitive flexibility in the follow-up phase
timeFrame: week 33
measure: Baseline of cognitive flexibility variante
timeFrame: week 0
measure: Mean Change from Baseline in cognitive flexibility variante
timeFrame: week 21
measure: cognitive flexibility variante in the follow-up phase
timeFrame: week 33
measure: Baseline of working memory
timeFrame: week 0
measure: Mean Change from Baseline in working memory
timeFrame: week 21
measure: Working memory in the follow-up phase
timeFrame: week 33
Other outcomes:
Locations:
city: Seville
country: Spain
facility: Education Faculty
Study officials:
affiliation: University of Seville
name: manuel jesus j roldan, Sports Sci
role: PRINCIPAL_INVESTIGATOR
References: