Clinical trial NCT01616745: Phenotypic Clinical, and Genetic Characteristics of Patients With Nontuberculosis Mycobacteria
Official title: Characteristics of Patients With Nontuberculosis Mycobacteria in Korean Population
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Nontuberculosis Mycobacterial Lung Disease
Keywords: NTM Lung disease
NTM Lung disease patients enrolled in SNUH
Lead sponsor: Seoul National University Hospital
Sponsor class: OTHER
First posted: 2012-06-12
Enrollment: 500
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: persons met diagnostic criteria of NTM lung disease by ATS/IDSA on 2007

Brief summary: The purpose of this study is to elucidate phenotypic, clinical, and genetic characteristics of Korean Nontuberculosis Mycobacteria (NTM) patients.

Detailed description: To elucidate phenotypic, clinical, and genetic characteristics of Korean NTM patients.

Especially, to compare body mass index, positive rate of IGRA, and CFTR mutation with general Korean population.

Eligibility criteria: Inclusion Criteria:

* Persons met diagnostic criteria of NTM lung disease by ATS/IDSA on 2007

Exclusion Criteria:

* Already on treatment for NTM lung disease
* Appropriate exclusion of other lung diagnosis

Primary outcomes:
Secondary outcomes:
Other outcomes:
Locations:
city: Seoul
country: Korea, Republic of
facility: Seoul National University Hospital
Study officials:
affiliation: Seoul National University Hospital
name: Jae-Joon Yim, MD
role: PRINCIPAL_INVESTIGATOR
References:
citation: Jung HI, Kim SA, Kim HJ, Yim JJ, Kwak N. Anxiety and Depression in Patients With Nontuberculous Mycobacterial Pulmonary Disease: A Prospective Cohort Study in South Korea. Chest. 2022 Apr;161(4):918-926. doi: 10.1016/j.chest.2021.10.024. Epub 2021 Oct 28.
citation: Kwak N, Lee JH, Kim HJ, Kim SA, Yim JJ. New-onset nontuberculous mycobacterial pulmonary disease in bronchiectasis: tracking the clinical and radiographic changes. BMC Pulm Med. 2020 Nov 10;20(1):293. doi: 10.1186/s12890-020-01331-3.
citation: Kwak N, Whang J, Yang JS, Kim TS, Kim SA, Yim JJ. Minimal Inhibitory Concentration of Clofazimine Among Clinical Isolates of Nontuberculous Mycobacteria and Its Impact on Treatment Outcome. Chest. 2021 Feb;159(2):517-523. doi: 10.1016/j.chest.2020.07.040. Epub 2020 Jul 24.
citation: Kwak N, Kim SA, Choi SM, Lee J, Lee CH, Yim JJ. Longitudinal changes in health-related quality of life according to clinical course among patients with non-tuberculous mycobacterial pulmonary disease: a prospective cohort study. BMC Pulm Med. 2020 May 7;20(1):126. doi: 10.1186/s12890-020-1165-3.
citation: Kim HJ, Lee JH, Yoon SH, Kim SA, Kim MS, Choi SM, Lee J, Lee CH, Han SK, Yim JJ. Nontuberculous mycobacterial pulmonary disease diagnosed by two methods: a prospective cohort study. BMC Infect Dis. 2019 May 24;19(1):468. doi: 10.1186/s12879-019-4078-0.
citation: Kim SJ, Yoon SH, Choi SM, Lee J, Lee CH, Han SK, Yim JJ. Characteristics associated with progression in patients with of nontuberculous mycobacterial lung disease : a prospective cohort study. BMC Pulm Med. 2017 Jan 5;17(1):5. doi: 10.1186/s12890-016-0349-3.
citation: Lee AR, Lee J, Choi SM, Seong MW, Kim SA, Kim M, Chae KO, Lee JS, Yim JJ. Phenotypic, immunologic, and clinical characteristics of patients with nontuberculous mycobacterial lung disease in Korea. BMC Infect Dis. 2013 Nov 25;13:558. doi: 10.1186/1471-2334-13-558.