Clinical trial NCT05544747: Action Observation Therapy Versus Mirror Therapy on Upper Limb in Stroke
Official title: Comparison of Action Observation Therapy Versus Mirror Therapy on Upper Limb Physical Performance and Quality of Life in Stroke
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Stroke
Lead sponsor: Riphah International University
Sponsor class: OTHER
First posted: 2022-09-16
Enrollment: 50
Sex: ALL
Minimum age (years): 40
Maximum age (years): 60
Standard ages: ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: Stroke is a medical condition which causes the cessation of blood flow to the brain cells and results in cell death and ultimately can lead to motor disorders, perception disorders, language disorders, sensory disturbances.It is well known that stroke is the leading cause of death and one of the greatest causes of long-term motor disability in adults.The incidence of stroke is increasing day by day in low-income countries as compared to high-income countries because of the effects of not using evidence-based practice in health-related conditions in low-income countries. In the last few years, several approaches have been used for the recovery of hand dexterity after stroke. Among them, the Mirror therapy, task-oriented therapy, robot-assisted rehabilitation and action observation has gained greatest attention.Action observation training is one of the new developing rehabilitation technique that targets motor learning by the activation of mirror neurons and is the most important approach that targets the motor and functional recovery in stroke patients. In action observation training, the movements are produced because of the external stimuli in which actually the visual attention recruit the cerebellar-thalamic-cortical circuit of the brain. Action observation is based on activities of the motor neuron system and they discharge mostly in association with complex tasks as compared to simple tasks.


Eligibility criteria: Inclusion Criteria:

* Both male and female
* Middle cerebral artery stroke
* 1 to 6 months of stroke onset
* Baseline score of the Fugyl Myer Assessment is between 20 and 60 for the upper limb.
* Modified Ashworth scale with a score of 2 Ability to follow the study instructions-Mini mental state examination (MMSE) score \>25

Exclusion Criteria:

* Participants failing to fall in this category would be excluded from the study.
* Patients who cannot perform the active movement of the upper limb in pre-stroke condition due to musculoskeletal problems
* cardiopulmonary diseases which could hinder their ability to participate in the rehabilitation program in this study
* Patient with impaired cognition

Primary outcomes:
measure: Fugel Meyer assessment scale for upper limb
timeFrame: week 6
measure: Box and Block Test (BBT)
timeFrame: week 6
measure: Functional Independence Measure (FIM)
timeFrame: week 6
Secondary outcomes:
measure: Stroke Impact Scale (SIS) version 3.0
timeFrame: week 6
Other outcomes:
Locations:
city: Mansehra
country: Pakistan
facility: Helping hand institute of rehabilitation sciences
Study officials:
affiliation: Riphah International University
name: Ayesha Afridi, PhD*
role: PRINCIPAL_INVESTIGATOR
References: