Clinical trial NCT06515353: Gastrointestinal Bleeding and Atmospheric Pressure Relationship
Official title: The Effect of Atmospheric Pressure on Patients Presenting to the Emergency Department With Gastrointestinal Bleeding
Study type: OBSERVATIONAL
Overall status: RECRUITING
Conditions: Atmospheric Pressure; Adverse Effect
GastroIntestinal Bleeding
Keywords: atmospheric pressure
gastrointestinal bleeding
emergency department
Lead sponsor: Saglik Bilimleri Universitesi
Sponsor class: OTHER
Collaborators: name: Ankara Etlik City Hospital
First posted: 2024-07-23
Enrollment: 250
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: RETROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: Patients presenting to emergency department with gastrointestinal bleeding

Brief summary: This study aims to investigate whether atmospheric pressure has an effect on upper gastrointestinal bleeding (UGIB), which includes causes such as peptic ulcer disease, esophagitis, gastritis, gastrointestinal varices, Mallory-Weiss tears, and gastric cancer. The goal is to determine the impact of atmospheric pressure and gather information on its role in high-risk UGIB.

Detailed description: ur study aims to investigate the potential effects of changes in atmospheric pressure on gastrointestinal bleeding, and if such effects exist, to review treatment adjustments based on weather forecasts for hypertensive patients to prevent potential hypertensive emergencies and enhance patient comfort. This research poses no risk to patients and is purely observational and clinical in nature.

After initial evaluation upon presentation to the emergency department, patients will undergo routine emergency department monitoring for gastrointestinal bleeding, including physical examination, vital sign monitoring, evaluation of coagulation parameters, and hemoglobin levels. Apart from routine tests, no additional invasive or non-invasive procedures will be performed by us.

Obtained data from patients and atmospheric pressure data will be analyzed and evaluated. Results will be analyzed to determine any relation between gastrointestinal bleeding and atmospheric pressure changes

Eligibility criteria: Inclusion criteria:

Patients aged 18 and above Patients presenting to the emergency department with complaints of gastrointestinal bleeding, whether active or resolved Patients willing to participate in the study Patients from central districts of Ankara

Exclusion criteria:

Patients under the age of 18 Pregnant individuals Patients with a history of trauma at the time of admission Patients declaring they are from a city other than Ankara

Primary outcomes:
measure: gastrointestinal bleeding
timeFrame: 24 hours
Secondary outcomes:
Other outcomes:
Locations:
city: Ankara
country: Turkey
facility: Etlik City Hospital
state: Yenimahalle
Study officials:
affiliation: ass. prof. of organization
name: gulsen akcay, ass. prof.
role: STUDY_DIRECTOR
References:
citation: Guo CG, Tian L, Zhang F, Cheung KS, Leung WK. Associations of seasonal variations and meteorological parameters with incidences of upper and lower gastrointestinal bleeding. J Gastroenterol Hepatol. 2021 Dec;36(12):3354-3362. doi: 10.1111/jgh.15632. Epub 2021 Jul 30.
citation: Prechter F, Burger M, Lehmann T, Stallmach A, Schmidt C. A study on the correlation of gastrointestinal bleeding and meteorological factors - is there a weather condition for GI bleeding? Z Gastroenterol. 2019 Dec;57(12):1476-1480. doi: 10.1055/a-1008-9863. Epub 2019 Dec 11.
citation: Lenzen H, Musmann E, Kottas M, Schonemeier B, Kohnlein T, Manns MP, Lankisch TO. Acute gastrointestinal bleeding cases presenting to the emergency department are associated with age, sex and seasonal and circadian factors. Eur J Gastroenterol Hepatol. 2017 Jan;29(1):78-83. doi: 10.1097/MEG.0000000000000752.