Clinical trial NCT03898206: Effects of Breaking up Prolonged Sitting on Postprandial Cardiometabolic Disease Risk Markers in South Asian Adults
Official title: Effects of Breaking up Prolonged Sitting on Postprandial Cardiometabolic Disease Risk Markers in Normal Weight Versus Overweight and Obese South Asian Adults
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Cardiovascular Risk Factor
Cardiovascular Diseases
Diabetes
Physical Activity
Sedentary Lifestyle
Lead sponsor: University of Bedfordshire
Sponsor class: OTHER
First posted: 2019-04-01
Enrollment: 66
Sex: ALL
Minimum age (years): 18
Maximum age (years): 65
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: CROSSOVER
Primary purpose: BASIC_SCIENCE

Brief summary: The purpose of this study is to examine whether breaking up prolonged sitting with short regular bouts of walking can reduce blood sugar and cholesterol levels after eating, which are risk markers for Type 2 diabetes and heart disease. This study will compare these responses in normal weight versus overweight/obese South Asian adults.

Detailed description: Participants will attend a preliminary testing session where height, weight, body fat and waist circumference will be measured. They will be familiarised with a motorised treadmill that will be used during the experimental visit below and will take part in an exercise test to determine a light-intensity walking speed for the experimental visit.

Participants will then attend two experimental visits in a random order:

1. Prolonged sitting: Participants will remain seated for 5 hours and instructed to reduce excessive movement.
2. Breaking up sitting with walking breaks: Participants will rise from the seated position every 30 minutes throughout the experimental period to walk on a motorised treadmill at a light intensity for 3 minutes. After performing walking activity, they will return to the seated position. In addition, blood sample will be taken at the resting position just before each physical activity bout. The activity breaks will be undertaken on 9 occasions, providing a total of 27 min of light intensity activity.

During each visit, blood pressure will be taken 11 times and blood samples will be taken 10 times. Participants will be given a breakfast and lunch meal to consume.

Eligibility criteria: Inclusion Criteria:

* Self-identified South Asian ethnicity.
* Self-report sitting at least 7 hours per day.
* Normal weight, overweight or obese.

Exclusion Criteria:

* Unable to speak and read English.
* Contraindications to performing light-intensity walking.
* Diagnosed cardiovascular disease or diabetes.

Primary outcomes:
measure: Postprandial glucose
timeFrame: Measured over the 5 hour condition period
Secondary outcomes:
measure: Postprandial triglycerides
timeFrame: Measured over the 5 hour condition period
measure: Postprandial insulin
timeFrame: Measured over the 5 hour condition period
measure: Blood pressure
timeFrame: Measured over the 5 hour condition period
Other outcomes:
Locations:
city: Bedford
country: United Kingdom
facility: University of Bedfordshire
state: Bedfordshire
Study officials:
References: