Clinical trial NCT04498299: Stress Echocardiography in Patients Recovery From Mild COVID-19 Illness
Official title: Stress Echocardiography in Patients Recovery From Mild COVID-19 Illness
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Echocardiography, Stress
COVID-19
Hypertension, Pulmonary
Keywords: Echocardiography, Stress
COVID-19
Pulmonary Hypertension
Lead sponsor: Hospital Beneficencia Espanola de Puebla
Sponsor class: NETWORK
First posted: 2020-08-04
Enrollment: 30
Sex: ALL
Minimum age (years): 18
Maximum age (years): 45
Standard ages: ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Patients after the resolution of acute COVID-19 illness

Brief summary: With the appearance of the new SARS-COV2 virus, additional challenges are being imposed on the medical community after the resolution of acute COVID-19 illness, resulting in specific pathophysiologic mechanisms that while acutely damage the lung parenchyma might chronically impact the cardiopulmonary system.

This study aims to investigate changes after mild COVID-19 illness in echocardiographic indices at rest and stress.


Eligibility criteria: Inclusion Criteria:

* Having suffered mild COVID-19 illness
* PCR test negative after COVID-19 illness
* Men or women
* Age ≥18 years and \< 45.
* No history of other cardiovascular or lung disease.
* No cardiovascular risk factors, that is, arterial systemic hypertension, smoking, diabetes, dyslipidemia
* No ongoing or previous cardio or vasoactive treatment
* Able to use the semi-supine exercise bicycle
* Able to give informed consent

Exclusion Criteria:

* Poor acoustic window.
* Tricuspid regurgitation more than mild
* Professional sports activity
* Pregnancy
* Obesity (body mass index \[BMI\], ≥30 kg/m2).
* Inability to provide consent

Primary outcomes:
measure: • LA volume index
timeFrame: 3 minutes
measure: • LV telediastolic diameter
timeFrame: 3 minutes
measure: • LV telesystolic diameter
timeFrame: 3 minutes
measure: • LV posterior wall
timeFrame: 3 minutes
measure: • RA area
timeFrame: 3 minutes
measure: • RV basal dimensión
timeFrame: 3 minutes
measure: • RV mid cavity dimension;
timeFrame: 3 minutes
measure: • RV longitudinal dimension
timeFrame: 3 minutes
measure: • Distal, RV outflow tract dimension at the distal or pulmonic valve level
timeFrame: 3 minutes
measure: • Proximal RV outflow tract dimension at the proximal subvalvular level
timeFrame: 3 minutes
measure: • TAPSE
timeFrame: 3 minutes
measure: • RV free Wall strain
timeFrame: 3 minutes
measure: • Inferior cava vein PW Doppler
timeFrame: 3 minutes
measure: • E wave mitral
timeFrame: 3 minutes
measure: • A wave mitral
timeFrame: 3 minutes
measure: • E wave /A wave mitral
timeFrame: 3 minutes
measure: • E-wave at mitral annulus
timeFrame: 3 minutes
measure: • E-wave at mitral annulus / A-wave at the mitral annulus
timeFrame: 3 minutes
measure: • E wave/ E-wave at the mitral annulus
timeFrame: 3 minutes
measure: • E tricuspid (E)
timeFrame: 3 minutes
measure: • A tricuspid (A)
timeFrame: 3 minutes
measure: • E/A
timeFrame: 3 minutes
measure: • Systolic pulmonary artery pressure
timeFrame: 3 minutes
measure: • E-wave at the tricuspid annulus
timeFrame: 3 minutes
measure: • Mean pulmonary artery pressure
timeFrame: 3 minutes
measure: • Stroke volume
timeFrame: 3 minutes
measure: • Cardiac output
timeFrame: 3 minutes
Secondary outcomes:
Other outcomes:
Locations:
city: Puebla
country: Mexico
facility: Hospital Beneficencia Española de Puebla
Study officials:
References: