Clinical trial NCT03485742: Statin Eligibility Prior to Myocardial InfarCtion
Official title: Statin Eligibility Prior to Myocardial InfarCtion in Jordanians
Study type: OBSERVATIONAL
Overall status: TERMINATED
Conditions: Statins
Myocardial Infarction
Lead sponsor: Jordan Collaborating Cardiology Group
Sponsor class: OTHER
First posted: 2018-04-02
Enrollment: 740
Sex: ALL
Minimum age (years): 30
Maximum age (years): 75
Standard ages: ADULT
OLDER_ADULT
Observational model: COHORT
Time perspective: CROSS_SECTIONAL
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Patients aged 30 to 75 years admitted with MI (ST elevation and non ST elevation) who are not receiving statins prior to admission will be evaluated for potential eligibility had they been evaluated prior to admission with MI.

Brief summary: The study (Statin Eligibility Prior to myocardial infarction (MI) in Jordanians, StatinEPIC) is

1. Cross sectional
2. Non interventional
3. One encounter per patient. No follow up. It addresses a major issue of primary prevention in Jordanians especially the young population, namely the issue of lipid lowering agents before sustaining an acute MI. A recent study in USA showed that 50% of patients who sustained MI were not eligible to statins had they been evaluated before the heart attack. It is largely unknown if a larger percentage of Middle Eastern patients who sustain a heart attack would be eligible to receive lipid lowering agents.
4. The PI will overlook the whole process. Dr Ahmad Tamari, the assistant to the PI will asses this whole process of data collection, management and manuscript drafting.

Detailed description: Statins, when use as primary cardiovascular prevention strategy, have been shown to lower future acute cardiovascular events, especially myocardial infarction. However the use of statins in this context (i.e., primary prevention) is governed by guidelines that limit the use of statins to four high risk populations: (1) hose with known cardiovascular disease, (2) those with low-density lipoprotein cholesterol (LDL-C) levels 190 mg/dl or above, (3) diabetics with LDL-C levels 70-189 mg/dl, and (4) those with an estimated 10-year atherosclerotic cardiovascular disease risk score of 7.5% or more.

Unfortunately, some individuals are still at risk of sustaining MI despite the fact that they do not fit into one of these four high risk groups eligible for statins.

StainEPIC will enroll consecutive patients admitted with MI who are not on statins to examine their eligibility for these medications based on the AHA/ACC guidelines.

Eligibility criteria: Inclusion Criteria:

* Adults admitted with MI, age 30 to 75
* known lipid profile

Exclusion Criteria:

* on statin before enrollment

Primary outcomes:
measure: Eligible patients for statin therapy
timeFrame: Within 24 hour of enrollment
Secondary outcomes:
Other outcomes:
Locations:
city: Amman
country: Jordan
facility: Istishari Hospital
city: Amman
country: Jordan
facility: The University of Jordan
city: Amman
country: Jordan
facility: Jordan Hospital
city: Amman
country: Jordan
facility: Khalidi Hospital & Medical Center
city: Irbid
country: Jordan
facility: King Abdullah University Hospital
Study officials:
affiliation: Hashemmeyyeh University School of Medicine, Zarka, Jordan
name: Yasmine Obeidat, MS
role: STUDY_DIRECTOR
affiliation: Istishari Hospital, Department of Cardiology, Amman, Jordan
name: Ayman J Hammoudeh, MD, FACC
role: PRINCIPAL_INVESTIGATOR
References: