Clinical trial NCT06454513: Efficacy of Different Anesthesia Methods in Transbronchial Biopsy
Official title: Exploration on the Efficacy of Different Anesthesia Methods in Transbronchial Biopsy
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Anesthesia
Respiratory Diseases
Biopsy
Keywords: Anesthesia method
Bronchoscopic biopsy
Efficiency research
Lead sponsor: Sichuan Provincial People's Hospital
Sponsor class: OTHER
First posted: 2024-06-12
Enrollment: 800
Sex: ALL
Minimum age (years): 18
Maximum age (years): 90
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: RETROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: All patients who require biopsy to further clarify the nature of lung lesions

Brief summary: This study investigates the efficacy of different anesthesia methods (general anesthesia with laryngeal mask airway and local nebulized anesthesia) for transbronchial biopsy using an electronic bronchoscope. The study retrospectively analyzed cases of transbronchial biopsy performed at the Respiratory Endoscopy Center of Sichuan Provincial People's Hospital from June 5, 2020, to June 5, 2024. Data collected included age, gender, primary diagnosis, anesthesia method, biopsy method, operation time (excluding general anesthesia and laryngeal mask airway placement time), lesion location and size, pathological results, and follow-up status.

Detailed description: General anesthesia and local anesthesia are the primary anesthesia methods for interventional respiratory endoscopy. While general anesthesia offers greater comfort, it carries anesthesia-related risks. Local anesthesia, on the other hand, provides a relatively low surgical risk and cost-effectiveness. However, there is limited research on whether its diagnostic value is inferior to that of general anesthesia.This study investigates the efficacy of the two anesthesia methods (general anesthesia with laryngeal mask airway and local nebulized anesthesia) for transbronchial biopsy. The study retrospectively analyzed cases of transbronchial biopsy performed at the Respiratory Endoscopy Center of Sichuan Provincial People's Hospital from June 5, 2020, to June 5, 2024. Data collected included age, gender, primary diagnosis, anesthesia method, biopsy method(forcep/cryobiopsy), operation time (excluding general anesthesia and laryngeal mask airway placement time), lesion location and size, pathological results, and follow-up status(pneumothorax、hemorrhage).

Eligibility criteria: Inclusion Criteria:

* Completed Transbronchial Biopsy；the platelets count and PT, APTT tests were normal, normal ECG, Anesthesiologist evaluation was needed in General anesthesia group.

Exclusion Criteria:

* patients with contraindication of bronchoscopy (such as respiratory failure and acute cardio-cerebrovascular events), and women who were pregnant.

Primary outcomes:
measure: Diagnostic efficacy
timeFrame: baseline
Secondary outcomes:
measure: Clinical information
timeFrame: baseline
measure: lesion location (left/right/other)
timeFrame: baseline
measure: lesion size (mm)
timeFrame: baseline
measure: Postoperative complications (hemorrhage or pneumothorax）
timeFrame: baseline
measure: Operation time
timeFrame: intraoperative
Other outcomes:
Locations:
city: Chengdu
country: China
facility: Sichuan Provincial People's Hospital
state: Sichuan
Study officials:
affiliation: Sichuan Academy of Medical Sciences
name: Guanghong G Zhou
role: PRINCIPAL_INVESTIGATOR
References: