Clinical trial NCT02534298: Functional Magnetic Resonance Imaging Study of the Central Auditory System After Single Sided Deafness
Official title: Reorganization of Central Auditory System After Single Sided Deafness: a Functional Magnetic Resonance Imaging Study
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Unilateral Hearing Loss
Keywords: single sided deafness.
Auditory plasticity
Asymmetrical hearing loss
Cochlear implants
Inter hemispheric asymmetry
Lateralization index
Dichotic hearing
Lead sponsor: University Hospital, Toulouse
Sponsor class: OTHER
First posted: 2015-08-27
Enrollment: 30
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: NON_RANDOMIZED
Intervention model: SINGLE_GROUP
Primary purpose: BASIC_SCIENCE

Brief summary: The objective is to study the relation between the reorganization of the central auditory system, and the psychophysical deficits in binaural hearing in subjects with single sided deafness.

Detailed description: Background Single sided deafness (SSD) and asymmetrical hearing loss are common hearing impairments, and their social consequences are well established. At the central auditory system level, the single sided deafness is associated with a reorganization of auditory temporal cortices that leads to a reduction of inter hemispheric asymmetry.

Purpose : Our main objective is to study the relation between the reorganization of the central auditory system, namely the inter hemispheric asymmetry, and the psychophysical deficits in binaural hearing in subjects with SSD.

Abstract : Binaural hearing enables spatial localization of the sound source and improves speech recognition in a competing noise. SSD and asymmetrical hearing loss are common hearing impairments, which affect 0.3 to 1/1000 children. In the adult population, this prevalence increases with age. The impact of SSD and asymmetrical hearing loss on quality of life indices is well established and some reports underline its consequences in children scholarship. Previous neuro-imaging and electro physiological studies highlighted the reduction of normal inter hemispheric asymmetry in subjects with SSD. To the best of our knowledge, there is no report about the relation between the central auditory system reorganization and its behavioural deficits.

The investigators propose to conduct a study which analyzes the relationship between the reduction of inter hemispheric asymmetry and performance in binaural hearing tests. Thus, the auditory plasticity will be studied using functional magnetic resonance imaging and more specifically BOLD variations in auditory temporal cortices. A set of binaural hearing assessments will be performed, including speech recognition in noise and localization abilities. The correlation between the lateralization ratio and binaural measurements (speech reception threshold (SRT) in dichotic hearing, diotic hearing, reverse dichotic hearing) will be estimated. Likewise, the impact of SSD duration on cortical reorganization and binaural tests will be studied.

Eligibility criteria: Inclusion Criteria:

* Right-handed subjects
* SSD confirmed using evoked auditory potentials

Exclusion Criteria:

* Associated neurological disorder

Primary outcomes:
measure: Lateralization index
timeFrame: 4 weeks
measure: Speech Reception Threshold
timeFrame: 4 weeks
Secondary outcomes:
measure: SRT in reverse dichotic hearing, mean localization error angle
timeFrame: 4 weeks
measure: the percentage of errors in test horizontal location of the sound source
timeFrame: 4 weeks
measure: seniority of deafness
timeFrame: inclusion
Other outcomes:
Locations:
city: Toulouse
country: France
facility: University Hospital of Toulouse
Study officials:
affiliation: University Hospital of Toulouse
name: Mathieu Marx, MD
role: PRINCIPAL_INVESTIGATOR
References: