Clinical trial NCT04861818: The Role of the Time of Day in the Effects of Exercise on Memory in Heathy Young Adults
Official title: The Role of the Time of Day in the Effects of Exercise on Memory in Heathy Young Adults
Study type: INTERVENTIONAL
Overall status: RECRUITING
Phase: NA
Conditions: Aerobic Exercise
Cognitive Change
Keywords: Aerobic exercise
Physical activity
Cognition
Lead sponsor: University of North Carolina, Greensboro
Sponsor class: OTHER
First posted: 2021-04-27
Enrollment: 80
Sex: ALL
Minimum age (years): 18
Maximum age (years): 25
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: BASIC_SCIENCE

Brief summary: Cumulative evidence indicates that a single bout of exercise has beneficial impacts on memory in young adults. From a physiological perspective, acute exercise leads to changes of heart rate variability (HRV), which is associated with memory retrieval process. From a psychological perspective, acute exercise increases the arousal level and thus facilitates cognitive processing including memory storage and retrieval. Such HRV- and/or arousal-based effects of exercise on memory could be differed by the time of day in young adults based on their circadian rhythms of HRV. Moreover, young adults prefer afternoon or evening to morning in their circadian rhythms, demonstrating less wakefulness and lower memory performance in the morning relative to afternoon. Based on the potential psychophysiological mechanisms, exercise could impact young adults' memory differently by the time of day. The investigators aim to 1) determine the extent to which the time of day modulates how moderate-intensity cardiovascular exercise impacts verbal-auditory and visuospatial short- and long-term memory in young adults, and 2) consider potential psychological and physiological markers that may mediate exercise's effects on cognitive performance. As cognitive benefits of exercise might differ by the time of day, it is important to investigate such interaction and make the right recommendations of the timing of exercise for young adults in academic settings.

Detailed description: Cumulative evidence indicates that a single bout of exercise has beneficial impacts on short- and long-term memory in young adults. From a physiological perspective, acute exercise leads to changes of heart rate variability (HRV), which is associated with memory retrieval process. From a psychological perspective, acute exercise increases the arousal level and thus facilitates cognitive processing including memory storage and retrieval. Such HRV- and/or arousal-based effects of exercise on memory could be differed by the time of day in young adults based on their circadian rhythms of HRV; sleep-wake transition led to rapid changes of HRV. Moreover, young adults prefer afternoon or evening to morning, showing less wakefulness and lower memory performance in the morning relative to afternoon. Based on the potential physiological and/or psychological mechanisms, exercise could impact young adults' memory differently by the time of day. Few studies, however, tested the effects of exercise on memory based on the time of day; rather, a recent study found null effects of exercise-induced arousal on implicit and explicit memory performance in college students in the morning.

The investigators here aim to 1) determine the extent to which the time of day moderates how moderate-intensity cardiovascular exercise impacts verbal-auditory and visuo-spatial short- and long-term memory in young adults, and 2) consider potential physiological and psychological markers that may mediate exercise's effects on cognitive performance. Specifically, the investigators will conduct a mixed-design randomized experiment to compare the effects of a single session of moderate-intensity cardiovascular exercise on cognitive performance at two times of day - in the morning (7 - 9 AM) and late afternoon (3 - 5 PM). Participants in each of two groups (morning versus afternoon) will complete two sessions of cognitive tests - at baseline without exercise and after an exercise intervention, while their emotional states, arousal levels, and heart rate (HR) will be measured at baseline, before, during, and after the exercise and memory sessions. The hypotheses are 1) acute exercise in the morning will be more beneficial for short- and long-term memory than an equal volume of exercise in the afternoon; 2) resting HRV and changes in perceived arousal and emotional states will be associated with memory performance following the exercise intervention. The rationale for the hypotheses is that cognitive benefits of exercise can differ by the preference for the time of day, so it is important to investigate such interactions to inform recommendations of the timing of exercise for young adults in academic settings. Moreover, exploring the role of psychophysiological markers in mediating exercise effects on cognition help to further understanding of the benefits of exercise for brain health.

Eligibility criteria: Inclusion Criteria:

* Between the ages of 18-25.
* Currently meeting the American College of Sports Medicine's recommended guidelines of activity (at least 90 min/week of moderate and/or vigorous physical activity).
* Willing to participate for 4 days (2 visits) and refrain from exercise outside of the lab for 4 days (1 day before and the day of two visits).

Exclusion Criteria:

* Any known history of cardiac, pulmonary, or metabolic disease (e.g. cardiovascular disease, asthma, diabetes).
* A current musculoskeletal injury, mental illness (e.g., depression, anxiety, or stress disorders), or sleep disorder.

Primary outcomes:
measure: Verbal episodic memory change
timeFrame: Immediately after the intervention, the first cognitive test
measure: Visual episodic memory change
timeFrame: Immediately after the intervention, the second cognitive test
measure: Lure discrimination index change
timeFrame: Immediately after the intervention, the third cognitive test
measure: Working memory change
timeFrame: Immediately after the intervention, the fourth cognitive test
Secondary outcomes:
Other outcomes:
Locations:
city: Greensboro
country: United States
facility: UNC Greensboro
state: North Carolina
Study officials:
affiliation: UNC Greensboro
name: Kyoung Shin Park, PhD
role: PRINCIPAL_INVESTIGATOR
References: