Clinical trial NCT01816451: Physiologic Adaptations to Interval and Continuous Running at Low Volume and Vigorous Intensity Over 14-Weeks.
Official title: Physiological Responses to Constant-load (Continuous) vs. Variable-intensity (Interval) During 14 Weeks of Supervised Aerobic Exercise on Active Men.
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Exhaustion - Physiological
Keywords: aerobic capacity
cardiorespiratory training
blood lactate concentration
heart rate
Lead sponsor: University of Trás-os-Montes and Alto Douro
Sponsor class: OTHER
First posted: 2013-03-22
Enrollment: 35
Sex: MALE
Minimum age (years): 25
Maximum age (years): 32
Standard ages: ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: FACTORIAL
Primary purpose: BASIC_SCIENCE

Brief summary: The purpose of this study was to verify physiological responses to constant-load (continuous) vs. variable-intensity (interval) during 14 weeks of aerobic exercise on active men. The hypothesis was that would be differences in physiological variables on distinct modes of execution performed on the treadmill over a period of 14 weeks of training.

Detailed description: Initially there were thirty five subjects, but due factors outside the present study, three individuals were excluded from the program. Two individuals during maximal exercise test (VO2) showed clinical impairment test being interrupted by the doctor and the third individual presented a plantar fasciitis in the early familiarization. Thirty two healthy and active males volunteered to participate in the study. All subjects exercised habitually, with at least 1 year experience aerobic training. The Human Ethics Committee of Rio de Janeiro Federal University approved this study (no 58659/02471312.8.0000.5257).The subjects performed a total of nine visits to the laboratory of the Brazilian Navy at City of Rio de Janeiro for physical tests on different days, except between visits I-II and VII-III. The interval between visits was one week between visits II-III-IV and VIII-IX, six weeks between the first day of training and visits V, four weeks between V-VI-VIII. All subjects from interval and continuous groups performed a total of 46 sessions of supervised running program.

Eligibility criteria: Inclusion Criteria:

* self reporting no contraindication to high-intensity exercise.
* physically active on cardiorespiratory activities in a regular basis for at least six months.
* presence of negative responses on all items of the Questionnaire of Physical Activity Readiness (PAR-Q Test).

Exclusion Criteria:

* make use of medication that may interfere with the results, especially inhibitors appetites and dietary supplements.
* presence of joint problems that prevents the achievement of training.
* presence of disorders such as diabetes, dyslipidemia and anemia
* have performed intense exercise with lowers members before the training sessions.

Primary outcomes:
measure: Relative Maximal Oxygen Uptake
timeFrame: Pre and post 14 weeks
measure: Absolute Maximal Oxygen Uptake
timeFrame: Pre and post 14 weeks
measure: Total Time Reaching on Maximal Test (tVO2max)
timeFrame: Pre and post 14 weeks/46 sessions of training
measure: Heart Rate on Maximal Test
timeFrame: Pre and post 14 weeks at rest (5 min sitting; before start the test), during the test (to determine max), and 60s and 120s immediately after the end of the test (on sitting position)
measure: Blood Lactate Concentrations on Maximal Test
timeFrame: Pre and post 14 weeks/46sessions on rest (5 min sitting position; before start the test); 1-3-5 min immediately after the end of the test (on sitting position).
measure: Body Mass (BM)
timeFrame: Body Mass was collected pre and post training
measure: Rate of Perceived Exertion (RPE) on Maximal Test
timeFrame: Pre and post 14 weeks/46 sessions of training
measure: Fat Mass (%)
timeFrame: Pre and post 14 weeks/46 sessions of training
Secondary outcomes:
measure: Heart Rate on Submaximal Test
timeFrame: Pre; during (retest I 0-6weeks; retest II 0-10 weeks) and post 14 weeks/46sessions training: rest (5-min sitting; before start the test); maximal during the test (maxHRsub); 60s-120s immediately after the end of the test (on sitting position).
measure: Blood Lactate on Submaximal Test
timeFrame: Pre; during (retest I 0-6weeks; retest II 0-10 weeks) and post 14 weeks/46 sessions training: rest (5-min sitting; before start the test); 1-3-5 minutes immediately after the end of the test (on sitting position).
measure: Submaximal Velocity [Vsub]
timeFrame: Pre; during (retest I 0-6weeks; retest II 0-10 weeks) and post 14 weeks/46sessions of training
measure: Rate of Perceived Exertion (RPE) on Submaximal Test
timeFrame: Pre; during (retest I 0-6weeks; retest II 0-10 weeks) and post 14 weeks/46sessions training
Other outcomes:
Locations:
city: Rio de Janeiro
country: Brazil
facility: CEFAN
Study officials:
affiliation: University of Trás-os-Montes and Alto Douro
name: Laura C Garay, Ph.D.
role: PRINCIPAL_INVESTIGATOR
References: