louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT06814847: Artificial Intelligence-Based Analysis of Uroflowmetry Patterns in Children: a Machine Learning Perspective
Official title: Interpretation of Uroflowmetry Samples from Pediatric Patients by Clinicians and Introduction to Artificial Intelligence, and Interpretation of the Samples by Artificial Intelligence
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Voiding Dysfunction
Voiding Disorders
Machine Learning
Keywords: Uroflowmetry voiding patterns
Interpretation differences
Machine learning
Artificial intelligence
Lead sponsor: Marmara University
Sponsor class: OTHER
First posted: 2025-02-07
Enrollment: 500
Sex: ALL
Minimum age (years): 4
Maximum age (years): 17
Standard ages: CHILD
Accepts healthy volunteers: yes
Observational model: CASE_ONLY
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: Children aged 4-17

Brief summary: Uroflowmetry is the one of the most commonly used non-invasive test for evaluating children with lower urinary tract symptoms (LUTS). However, studies have highlighted a weak agreement among experts in interpreting uroflowmetry patterns. This study aims to assess the impact of machine learning models, which have become increasingly prevalent in medicine, on the interpretation of uroflowmetry patterns.

Detailed description: The study included uroflowmetry tests of children aged 4-17 years who were referred to our clinic with lower urinary tract symptoms. Uroflowmetry patterns were independently interpreted by three pediatric urology experts. Discrepancies in interpretations were jointly re-evaluated by the three observers, and a consensus was reached. Voiding volume, voiding duration, and urine flow rates at 0.5-second intervals were converted into numerical data for analysis. Eighty percent of the dataset was used as training data for machine learning, while there maining 20% was reserved for testing. A total of five different machine learning models were employed for classification: Decision Tree, Random Forest, CatBoost, XGBoost, and LightGBM. The models that most accurately identified each uroflowmetry pattern were determined.

Eligibility criteria: Inclusion Criteria:

* Aged between 4 and 17 years with LUTS
* Urinate more than 50% of the expected bladder capacity on UF

Exclusion Criteria:

* Patients who were unable to cooperate with the voiding command
* Had neurological disorders
* Urinate less than 50% of the expected bladder capacity on UF
* Under 4 years of age, and were over 18 years of age

Primary outcomes:
measure: Performance of Machine Learning Models in Evaluating Voiding Patterns
timeFrame: From October 2024 to January 2025
Secondary outcomes:
Other outcomes:
Locations:
city: Istanbul
country: Turkey
facility: Marmara University School of Medicine, Urology Department
Study officials:
References:
Clinical trial NCT03429647: Intraoperative Perfusion Patterns of the Sigmoid Colon During Elective Open Abdominal Aortic Aneurysm Repair
Official title: Intraoperative Perfusion Patterns of the Sigmoid Colon During Elective Open Abdominal Aortic Aneurysm Repair
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Abdominal Aortic Aneurysm
Lead sponsor: University Hospital, Basel, Switzerland
Sponsor class: OTHER
First posted: 2018-02-12
Enrollment: 20
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: DIAGNOSTIC

Brief summary: Blood supply to the sigmoid colon during open abdominal aortic aneurysm (AAA) repair is at risk. Ischemia of the sigmoid colon after AAA repair is potentially devastative. No reliable measures to prevent it are available and the underlying mechanisms are poorly understood. The aim of this study is to describe intraoperative perfusion patterns of the sigmoid colon during open AAA repair and their potential impact on postoperative outcome.


Eligibility criteria: Inclusion Criteria:

* undergoing elective open AAA repair between 2013 and 2016 were eligible for this study

Exclusion Criteria:

* No informed consent
* emergency cases

Primary outcomes:
measure: saturation in the sigmoid colon
timeFrame: intraoperative day
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
affiliation: University Hospital, Basel, Switzerland
name: Jasmin Zeindler, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT06608147: MOLyF : Bone Marrow and Follicular Lymphoma
Official title: Bone Marrow and Follicular Lymphoma
Study type: INTERVENTIONAL
Overall status: RECRUITING
Phase: NA
Conditions: Lymphoma, Follicular
Lead sponsor: Rennes University Hospital
Sponsor class: OTHER
First posted: 2024-09-23
Enrollment: 200
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: BASIC_SCIENCE

Brief summary: This is a prospective single-center study designed to assess potential differences in cell composition between bone marrows of patients with follicular lymphoma and those from control subjects.

Follicular lymphoma is the most common indolent lymphoma. It is characterised by systematic relapses and bone marrow dissemination in 70% of patients at the time of diagnosis.

Although relapses are thought to be related to refractory tumour cells nested in a supportive microenvironment in the bone marrow, the mechanisms involved are poorly understood.

To study the specificities of the bone marrow of patients with follicular lymphoma, It is necessary to compare them with control samples.

This study takes advantage of surgeries involving sternotomies to recover lost bone marrow and establish a bone marrow bank of patients without hematological disease.

This bank will be used to set up control cohorts for other clinical trials involving patients with follicular lymphoma.


Eligibility criteria: Inclusion Criteria:

* Major patient
* Patient hospitalized in the thoracic, cardiac and vascular surgery department for surgery involving a sternotomy
* Patient with free, informed, written consent
* Patient covered by a health insurance scheme

Exclusion Criteria:

* History of haematological malignancy or haemogram disturbance
* Immunomodulating treatment: immunosuppressants, corticoids, antineoplastics
* Persons covered by articles L. 1121-5 to L. 1121-8 and L. 1122-1-2 of the French Public Health Code (e.g. minors, protected adults, etc.)\].

Primary outcomes:
measure: Flow cytometric quantification of cell populations
timeFrame: 1 day
Secondary outcomes:
Other outcomes:
Locations:
city: Rennes
country: France
facility: CHU Rennes
Study officials:
affiliation: CHU Rennes
name: Juliette Ferrant, MD
role: STUDY_CHAIR
References:
Clinical trial NCT03902847: Motor Imagery and Action Observation on Lumbar Motor Variables
Official title: Efficacy of an Intensive Exercise Program Combined With Training on Action Observation and Motor Imagery for Improving Lumbopelvic Motor Control and Strengthening Trunk Muscles: A Randomized Controlled Trial
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Motor Activity
Keywords: motor imagery
action observation
motor learning
Lead sponsor: Universidad Autonoma de Madrid
Sponsor class: OTHER
First posted: 2019-04-04
Enrollment: 45
Sex: ALL
Minimum age (years): 18
Maximum age (years): 65
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: BASIC_SCIENCE

Brief summary: Motor imagery is defined as a dynamic mental process of an action, without its real motor execution. Action observation evokes an internal, real-time motor simulation of the movements that the observer is perceiving visually. Both MI and AO have been shown to produce a neurophysiological activation of the brain areas related to the planning and execution of voluntary movement in a similar manner how the real action.


Eligibility criteria: Inclusion Criteria:

The inclusion criteria were as follows:

* asymptomatic participants
* men and women aged 18 to 65 years.

Exclusion Criteria:

The exclusion criteria included the following:

* participants who had any knowledge of Physical Therapy or Occupational Therapy
* underage participants
* participants with any symptomatology in the lumbo-pelvic region at the time of the study -participants with lumbo-pelvic pain in at least the prior six months
* subjects who have been treated for lumbo-pelvic pain in the previous 6 months
* participants with any type of neurological disease.

Primary outcomes:
measure: Changes in the Right Lumbo-pelvic motor control
timeFrame: 1 week and 3 weeks
measure: Changes in the Left Lumbo-pelvic motor control
timeFrame: 1 week and 3 weeks
Secondary outcomes:
measure: Perceived fatigue: changes in the Visual Analogue Scale-fatigue mid-intervention
timeFrame: 1 week and 3 weeks.
measure: Changes in the trunk muscles strength
timeFrame: 1 week and 3 weeks.
Other outcomes:
Locations:
city: Madrid
country: Spain
facility: CSEU La Salle
Study officials:
References:
Clinical trial NCT04324177: Profile of Pediatric Patients Admitted to AU ICU
Official title: Profile and Clinical Outcome of Pediatric Patients Admitted to Intensive Care Unit of Assiut University Children Hospital
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Critical Illness
Lead sponsor: Assiut University
Sponsor class: OTHER
First posted: 2020-03-27
Enrollment: 100
Sex: ALL
Minimum age (years): 1
Maximum age (years): 18
Standard ages: CHILD
ADULT
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: All patients admitted to the PICU whichever is the diagnosis

Brief summary: This study aims to determine the profile and outcome of children admitted to ICU at Assiut University children hospital in order to detect association between risk factors and outcome, to asses the efficacy of treatment making it possible to take better decisions , to improve the quality of care.


Eligibility criteria: Inclusion Criteria:

* all patients admitted to intensive care unit of Assiut University children hospital over one year aged from 1month to 18 years

Exclusion Criteria:

* pediatric patients less than one month old Pediatric patients will die on arrival

Primary outcomes:
measure: Number of patients according to age groups and gender
timeFrame: 1 year
measure: Number of patients according to diagnosis on admission
timeFrame: 1 year
measure: Number of patients according to referral site
timeFrame: 1 year
measure: Number of patients according to the need for mechanical ventilation and its duration
timeFrame: 1 year
measure: Length of stay in days
timeFrame: 1 year
measure: Pediatric Risk of Mortality score on admission
timeFrame: 1 year
measure: Number of patients according to the condition of discharge from the pediatric intensive care unit
timeFrame: 1 year
Secondary outcomes:
measure: Correlation 1
timeFrame: 1 year
measure: Correlation 2
timeFrame: 1 year
measure: Correlation 3
timeFrame: 1 year
measure: Correlation 4
timeFrame: 1 year
measure: Correlation 5
timeFrame: 1 year
Other outcomes:
Locations:
Study officials:
References:
citation: Haftu H, Hailu T, Medhaniye A, G/Tsadik T. Assessment of pattern and treatment outcome of patients admitted to pediatric intensive care unit, Ayder Referral Hospital, Tigray, Ethiopia, 2015. BMC Res Notes. 2018 May 24;11(1):339. doi: 10.1186/s13104-018-3432-4.
citation: Khilnani P, Sarma D, Singh R, Uttam R, Rajdev S, Makkar A, Kaur J. Demographic profile and outcome analysis of a tertiary level pediatric intensive care unit. Indian J Pediatr. 2004 Jul;71(7):587-91. doi: 10.1007/BF02724117.
Clinical trial NCT02128477: Predictive Value of Periodic Repolarization Dynamics in Post-Infarction Patients
Official title: Predictive Value of Periodic Repolarization Dynamics in Post-Infarction Patients: Validation Study
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Myocardial Infarction
Keywords: Myocardial infarction
Repolarization instability
Ventricular fibrillation
Lead sponsor: Thebiosignals.com
Sponsor class: OTHER
First posted: 2014-05-01
Enrollment: 754
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: myocardial infarction

Brief summary: Increased periodic repolarization dynamics (PRD) indicate increased risk of death in cardiac patients. This study thoughts to prospectively validate the prognostic value of PRD in post-infarction patients.

Detailed description: Periodic repolarization dynamics (PRD) reflect periodic changes of repolarization instability located in the low-frequency spectral range. Level of PRD can be assessed using a high resolution surface ECG recorded in the 12-leads of Frank leads configuration during resting conditions.

Increased levels of PRD have been associated with sympathetic overactivity and increased risk of mortality in survivors of acute myocardial infarction and patients undergoing a clinically indicated exercise test.

Eligibility criteria: Inclusion Criteria:

* previous myocardial infarction \>4 weeks
* age \>18 years

Exclusion Criteria:

* life expectancy \< 1 year due to non-cardiac causes
* unable to give informed consent

Primary outcomes:
measure: Number of total deaths
timeFrame: 24 months
Secondary outcomes:
measure: Number of cardiovascular deaths
timeFrame: 24 months
Other outcomes:
Locations:
city: Tuebingen
country: Germany
facility: Eberhard-Karls-University Tuebingen
state: Baden-Württemberg
Study officials:
References:
Clinical trial NCT03759977: Effects of an Adapted Physical Activity on the Postural Control of Residents in Nursing Home.
Official title: Effects of Adapted Physical Activity on the Static and Dynamic Postural Control of Residents in Nursing Home: an Exploratory Study of 8 Weeks in the Réseau Santé de la Glâne (Canton of Fribourg, Switzerland).
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Postural Control
Keywords: adapted physical activity
nursing home
elderly
postural control
Lead sponsor: University of Lausanne
Sponsor class: OTHER
First posted: 2018-11-30
Enrollment: 36
Sex: ALL
Minimum age (years): 70
Standard ages: OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: NON_RANDOMIZED
Intervention model: PARALLEL
Intervention model description: pre- posttest with control group
Primary purpose: PREVENTION

Brief summary: This study measures the effects of an Adapted Physical Activity on postural control of residents in nursing home. Half of participants will follow a program training 3 times a week during 8 weeks, while the other half will receive the usual accompaniment.


Eligibility criteria: Inclusion Criteria:

* Able to walk 20 meters with or without auxiliary help
* Able to stand 1 minute without help
* Health status considered stable
* Life expectancy greater than 6 months
* No major cognitive impairment preventing them from understanding a simple instruction
* No severe visual impairment
* No severe deafness
* Understanding french
* Able to discern

Exclusion Criteria:

* Unable to walk 20 meters with or without auxiliary help
* Unable to stand 1 minute without help
* Health status considered unstable
* Estimated life expectancy at less than 6 months
* Major cognitive impairment preventing them from understanding a simple instruction
* Severe visual impairment
* Severe deafness
* Not understanding french
* Inability to discern

Primary outcomes:
measure: Postural control
timeFrame: 15 minutes
Secondary outcomes:
measure: Habitual gait speed in meter per seconde
timeFrame: 5 minutes
measure: Gait variability in percentage
timeFrame: 5 minutes
measure: Gait asymmetry in percentage
timeFrame: 5 minutes
measure: Short Physical Performance Battery test
timeFrame: 10 minutes
measure: General quality of life
timeFrame: 5 minutes
measure: Depression
timeFrame: 5 minutes
measure: Fear of falling
timeFrame: 5 minutes
Other outcomes:
Locations:
city: Lausanne
country: Switzerland
facility: Université de Lausanne
Study officials:
affiliation: University of Lausanne
name: Vincent Gremeaux, Professor
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT05865977: dTDI During a SBT to Predict Extubation Failure in Preterm Infants
Official title: Diaphragmatic Tissue Doppler Imaging During a Spontaneous Breathing Trial to Predict Extubation Failure in Preterm Infants
Study type: OBSERVATIONAL
Overall status: RECRUITING
Conditions: Premature
Keywords: tissue Doppler imaging
Premature infants
extubation
diaphragm
Lead sponsor: Children's Hospital of Chongqing Medical University
Sponsor class: OTHER
First posted: 2023-05-19
Enrollment: 100
Sex: ALL
Minimum age (years): 2
Maximum age (years): 6
Standard ages: CHILD
Accepts healthy volunteers: no
Observational model: CASE_CONTROL
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: premature infants with gestational age \<32 weeks and supported by invasive mechanical ventilation ≥48 hours

Brief summary: Weaning from mechanical ventilation is a critical issue and the diaphragmatic disfunction has been demonstrated to play an important role in extubation failure. the aim of present investigation is to evaluate diaphragmatic excursion velocity during in patients undergoing spontaneous breathing trial through tissue Doppler analysis in both inspiration and expiration.


Eligibility criteria: Inclusion Criteria:

* premature infants with gestational age \<32 weeks and supported by invasive mechanical ventilation ≥48 hours
* All the indications for extubation are met：cough or vomiting due to spontaneous breathing and sputum aspiration; ventilator parameters in recent 24 hours: MAP \< 8cmH2O, RR \< 30 times/min, FiO2 \< 30%; Arterial blood gas: pH \> 7.25, (PaCO2\< 60mmHg, BE \< 8mmol/L, oxygen saturation \> 90%
* a successful SBT
* parents or legal guardians sign informed consent to attend this study

Exclusion Criteria:

* accidental extubation
* chest CT or bronchoscopy during hospitalization indicated congenital airway dysplasia
* complex congenital heart disease
* congenital metabolic diseases, neuromuscular diseases
* severe brain injury
* surgical mechanical ventilation
* give up before extubation;
* pneumothorax or pleural effusion
* no consent is signed

Primary outcomes:
measure: Change in diaphragmatic displacement velocity
timeFrame: an average of 20 minutes
Secondary outcomes:
measure: Diaphragmatic acceleration and deceleration
timeFrame: an average of 20 minutes
measure: Gas exchange - arterial carbon dioxide tension
timeFrame: through each trial completion, an average of 20 minutes
measure: Gas exchange - pH
timeFrame: an average of 20 minutes
measure: Gas exchange - arterial oxygen tension
timeFrame: an average of 20 min
measure: Silverman Andersen Respiratory Severity Score (SA-RSS)
timeFrame: an average of 20 min
measure: Number of patients who experienced weaning failure
timeFrame: 48 hours
Other outcomes:
Locations:
city: Chongqing
country: China
facility: Children's hospital of Chongqing Medical University
state: Chongqing
Study officials:
References:
Clinical trial NCT06336577: Infectious and Non-infectious Lower Respiratory Diseases in Children With Down Syndrome Followed in Pediatric Pulmonology Consultations in Ile-de-France
Official title: Infectious and Non-infectious Lower Respiratory Diseases in Children With Down Syndrome Followed in Pediatric Pulmonology Consultations in Ile-de-France
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Down Syndrome
Keywords: Down syndrome
children
lower respiratory diseases
respiratory infection
respiratory syncytial virus
hemosiderosis
asthma
bronchiolitis
Lead sponsor: Centre Hospitalier Sud Francilien
Sponsor class: OTHER
First posted: 2024-03-28
Enrollment: 108
Sex: ALL
Minimum age (years): 1
Maximum age (years): 17
Standard ages: CHILD
Observational model: COHORT
Time perspective: RETROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: children with Down syndrome, who were hospitalized for respiratory problems and who had subsequent pediatric pulmonology follow-up between 2013 and 2023

Brief summary: The purpose of this study is to describe infectious and non-infectious lower respiratory tract diseases in children with Down syndrome followed in pediatric pulmonology consultations in Ile de France.

Detailed description: Down syndrome is the most common chromosomal abnormality, affecting 600 to 800 births per year. It results in a clinical picture that combines developmental delay, mental deficiency, facial dysmorphism and visceral malformations.

Optimal medical care of Down syndrome patients requires a good knowledge of the different systems affected by the disease, particularly respiratory damage.

Numerous articles have been published describing upper respiratory problems in children with Down syndrome. On the other hand, lower respiratory problems causing significant morbidity and mortality remain underestimated and poorly understood in this population.

The objective of this study is to describe lower respiratory problems in patients with T21, in order to improve their management.

This study will also make it possible to describe more precisely the impact that these attacks have on Down syndrome patients.

This study also describe the associated extra-respiratory disorders to improve overall care Finally, the respiratory care of these patients will be described, with the aim of standardizing practices.

Eligibility criteria: Inclusion Criteria:

* Child from 0 to 17 years old
* Carrier of Down syndrome confirmed by karyotype
* Having had follow-up in a pediatric pulmonology consultation for an infectious or non-infectious lower respiratory tract
* Not exclusively presenting upper respiratory otorhinolaryngological damage

Exclusion Criteria:

* Patient under guardianship or curators
* Adult or holders of parental authority informed of the study and having objected to it

Primary outcomes:
measure: distribution of lower respiratory tract diseases
timeFrame: at day 0
Secondary outcomes:
Other outcomes:
Locations:
city: Corbeil-Essonnes
country: France
facility: Centre Hospitalier Sud Francilien
Study officials:
affiliation: C
name: Yousra MESBAHI, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT02575677: Oxycodone in Treatment of Early Labour Pain Efficacy and Safety
Official title: Oxycodone in Treatment of Early Labour Pain Efficacy and Safety
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Labor Pain
Keywords: labor pain
oxycodone
Lead sponsor: Kuopio University Hospital
Sponsor class: OTHER
Collaborators: name: Admescope Ltd
First posted: 2015-10-15
Enrollment: 90
Sex: FEMALE
Minimum age (years): 18
Maximum age (years): 65
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: Parturients who are in early labor and need some pain medication.

Brief summary: Oxycodone is used to treat early labour pain instead of meperidine. However, the efficacy and effects of oxycodone to the newborn has not been studied. In the present study, patient who has received oxycodone is asked about pain relief and after labour single venous blood sample from the parturient and umbilical cord are taken for the analysis of oxycodone.


Eligibility criteria: Inclusion Criteria:

* Oxycodone for pain relief
* age 18 years or more
* given informed consent

Exclusion Criteria:

* no oxycodone
* age less than 18 years
* no informed consent

Primary outcomes:
measure: Pain measured with numerical rating scale
timeFrame: from the time of oxycodone administration up to the birth of newborn, maximum of 48 hours
Secondary outcomes:
Other outcomes:
Locations:
city: Kuopio
country: Finland
facility: Kuopio University Hospital
state: Northern Savo
Study officials:
affiliation: Kuopio University Hospital
name: Merja Kokki, MD, PhD
role: PRINCIPAL_INVESTIGATOR
References: