louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT06021899: Effects of Classic and Modified CIMT on Quality of Life of Children With Hemiplegic CP
Official title: Effects of Classic Constraint Induced Movement Therapy and Its Modified Form on Quality of Life of Children With Hemiplegic Cerebral Palsy
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Hemiplegic Cerebral Palsy
Keywords: Constraint induced movement therapy
Cerebral palsy
CPQOL
Lead sponsor: Health Education Research Foundation (HERF)
Sponsor class: OTHER
First posted: 2023-09-01
Enrollment: 40
Sex: ALL
Minimum age (years): 4
Maximum age (years): 12
Standard ages: CHILD
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The purpose of this research is to see the effect of classic constraint-induced movement therapy and its modified form on quality of life of children with hemiplegic cerebral palsy. Randomized controlled trials with 2-3 weeks follow-up. The sample size is 40. The subjects are divided in two groups, 20 subjects in classical CIMT group and 20 in modified CIMT group. Study duration is of 6 months. Sampling technique applied will be purposive non probability sampling technique. Only 4-12 years individual with hemiplegic cerebral palsy are included. Tools used in the study are Cerebral palsy (quality of life) and Kid Screen 27.

Detailed description: Both CCIMT and MCIMT are effective treatments to improve quality of life of children with CP. However conflicting evidence is present on which one of these is more effective and no final conclusion can be made to date. This study intends to add to the literature and contribute in reaching final conclusion about the superiority of either intervention. The purpose of this study was to see the psychosocial effect (quality of life) of CIMT and its modified form on HCP

Eligibility criteria: Inclusion Criteria:

* 4 to 12 years CP with unilateral, bilateral or severely asymmetrical impairment Manual Ability Classification System(MACS) I, II or III Wrist extension capacity at least 20°; fingers with 10° of complete flexion Children able to follow Command

Exclusion Criteria:

* Children also having disabilities other than Cerebral palsy Contractures that significantly limit functional arm use. Children with MR

Primary outcomes:
measure: Cerebral Palsy Quality of Life CP(QOL)
timeFrame: 3 weeks.
Secondary outcomes:
measure: Kid Screen 27
timeFrame: 3 weeks
Other outcomes:
Locations:
city: Islamabad
country: Pakistan
facility: Yusra Institute of Rehablitation Science
Study officials:
affiliation: Riphah International University
name: Saad Tariq, master
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT04485299: Clinical Assessment of Bifluorid 10 vs Varnish Fluoride on The Exposed Hypersensitive Cervical Dentin in Adult Patient
Official title: Quantitative Clinical Assessment of Bifluorid 10 Versus Varnish Fluoride on The Exposed Hypersensitive Cervical Dentin in Adult Patient: A Randomized Clinical Trial
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: PHASE2
PHASE3
Conditions: Hypersensitivity
Dentin Sensitivity
Lead sponsor: Cairo University
Sponsor class: OTHER
First posted: 2020-07-24
Enrollment: 68
Sex: ALL
Minimum age (years): 18
Maximum age (years): 60
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: Aim of the study will be conducted to compare the efficacy of bifluoride (NaF and CaF) versus conventional fluoride varnish (Sodium Flouride) in the management of hypersensitivity of exposed cervical area in adult patients over 2 month


Eligibility criteria: Inclusion Criteria:

* Healthy patient with free medical history.
* Age range 18-60 years old.
* Good oral hygiene
* Patients suffering from pain due to dentin hypersensitivity.
* Patient with sound first molar .

Exclusion Criteria:

* Patients using desensitizing agents, receiving periodontal treatment or had received nonsurgical periodontal treatment in the last three months.
* Patient wearing orthodontic appliance.
* Patient with teeth having a painful condition involving the pulp and periapical region.
* Patients who had allergy to materials will be used in the study.
* Pregnancy.
* Patient who does not consent to participation.
* Patient who does not attend to the follow up.
* A patient who has a carious first molar.

Primary outcomes:
measure: Dentin hypersensitivity
timeFrame: pre-intervention
measure: Dentin hypersensitivity
timeFrame: 2 min
measure: Dentin hypersensitivity
timeFrame: 1 week
measure: Dentin hypersensitivity
timeFrame: 4 weeks
measure: Dentin hypersensitivity
timeFrame: 8 weeks
Secondary outcomes:
measure: Dentinal tubule occlusion
timeFrame: Pre-intervention
measure: Dentinal tubule occlusion
timeFrame: 8 weeks
Other outcomes:
Locations:
Study officials:
References:
Clinical trial NCT01698099: Diagnostic Accuracy of Serum Bilirubin in the Prediction of Perforated Appendicitis
Official title: Diagnostic Accuracy of Serum Bilirubin in the Prediction of Perforated Appendicitis
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Appendicitis
Lead sponsor: University Hospital Tuebingen
Sponsor class: OTHER
First posted: 2012-10-02
Enrollment: 500
Sex: ALL
Minimum age (years): 16
Maximum age (years): 95
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: RETROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: patients undergoing appendectomy for suspected appendicitis

Brief summary: Hyperbilirubinemia is reported to be a positive predictor in diagnosing perforated appendicitis. Therefore we analysed the diagnostic accuracy of serum bilirubin in discriminating between perforated and simple/no appendicitis.

Methods:

All consecutive patients undergoing appendectomy for suspected appendicitis from May 2009 to August 2011 were analysed. Primary endpoint was the diagnostic accuracy of serum bilirubin levels to detect perforated appendicitis.


Eligibility criteria: Inclusion Criteria:

* all patients undergoing appendectomy for suspected appendicitis

Exclusion Criteria:

* preexisting liver disease

Primary outcomes:
measure: Diagnostic accuracy of serum bilirubin
timeFrame: 24h within initial presentation with clinical symptoms
Secondary outcomes:
Other outcomes:
Locations:
city: Tuebingen
country: Germany
facility: Departement of Visceral- and Transplant Surgery, University of Tuebingen
Study officials:
affiliation: University Hospital Tuebingen
name: Sven Müller, MD
role: PRINCIPAL_INVESTIGATOR
References:
citation: Muller S, Falch C, Axt S, Wilhelm P, Hein D, Konigsrainer A, Kirschniak A. Diagnostic accuracy of hyperbilirubinaemia in anticipating appendicitis and its severity. Emerg Med J. 2015 Sep;32(9):698-702. doi: 10.1136/emermed-2013-203349. Epub 2014 Dec 4.
Clinical trial NCT03259399: A Pharmacogenomics Study of Safety and Efficacy of Enalapril or Enalapril-Folic Acid Therapy in Hypertensive Patients.
Official title: A Study of Genetic Variants Associated With Enalapril-Induced Adverse Drug Reaction and Impact of Pharmacogenomics on First Stroke in Hypertensive Patients Taking Enalapril or Enalapril-Folic Acid Therapy.
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Enalapril Adverse Reaction
Pharmacogenomics
Stroke
Lead sponsor: Peking University First Hospital
Sponsor class: OTHER
First posted: 2017-08-23
Enrollment: 2200
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: OTHER
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Chinese Patients:In accordance with anti-hypertension indications of enalapril

Brief summary: Dry cough is the most common adverse reaction of angiotensin converting enzyme, including enalapril, in Chinese population. Clinical observations suggest that the incidence of ACEI-induced dry cough is different between Chinese and other racial groups, however, there is still lack of research data in Chinese. Stroke is the second leading cause of death in the world and leading cause of death in China. Except the known risk factor such as hypertension, high homocysteine level, folic acid deficiency, the impact of genetics should not be ignored.

In this study, we will investigate whether there are specific genotypes which may predict the incidence of (1)enalapril-induced dry cough in Chinese and (2)first stroke in hypertensive patients taking enalapril or enalapril-folic acid therapy, so as to provide a basis for developing guidelines on precision medication in enalapril therapy apply to Chinese population.


Eligibility criteria: Inclusion Criteria:

* Patients taking enalapril or enalapril-folic acid therapy
* Signed informed consent.

Exclusion Criteria:

* Patients not taking enalapril treated
* Intolerance or unwillingness to blood sample collection.

Primary outcomes:
measure: Incidence of dry cough
timeFrame: At 2 years
measure: First Incidence of stroke
timeFrame: At 2 years
Secondary outcomes:
measure: Genotype detected by next generation sequencing
timeFrame: pre-dose of enalapril or enalapril-folic acid (Baseline)
Other outcomes:
Locations:
city: Beijing
country: China
facility: Peking University First Hospital
state: Beijing
Study officials:
References:
citation: Mu G, Xiang Q, Zhang Z, Liu C, Zhang H, Liu Z, Pang X, Jiang J, Xie Q, Zhou S, Wang Z, Hu K, Wang Z, Jiang S, Qin X, Cui Y. PNPT1 and PCGF3 variants associated with angiotensin-converting enzyme inhibitor-induced cough: a nested case-control genome-wide study. Pharmacogenomics. 2020 Jun;21(9):601-614. doi: 10.2217/pgs-2019-0167. Epub 2020 May 13.
Clinical trial NCT01680042: Clinical Effect of Phenytoin Mucoadhesive Paste on Wound Healing After Oral Biopsy
Official title: Phase 1 Study of Phenytoin Mucoadhesive Paste for Wound Healing After Oral Biopsy
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: PHASE1
Conditions: Wound Healing
Pain
Keywords: inflammatory halo
VAS
Lead sponsor: Shahid Beheshti University of Medical Sciences
Sponsor class: OTHER
First posted: 2012-09-06
Enrollment: 40
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: several studies have investigated healing effect of phenytoin.In this study we investigate healing effect of phenytoin mucoadhesive paste comparing to the usual mucoadhesive paste after oral biopsy.


Eligibility criteria: Inclusion Criteria:

* patients undergone oral biopsy

Exclusion Criteria:

* systemic disease

Primary outcomes:
measure: healing biopsy wound
timeFrame: 7 days
Secondary outcomes:
Other outcomes:
Locations:
city: Tehran
country: Iran, Islamic Republic of
facility: Shaheed Beheshti University
city: Tehran
country: Iran, Islamic Republic of
facility: Shahid Beheshti Medical University
Study officials:
References:
Clinical trial NCT03853642: Blood Eosinophil Measurements in Patients With Chronic Obstructive Pulmonary Disease
Official title: Blood Eosinophil Measurements Throughout the Day in Patients With Stable Chronic Obstructive Pulmonary Disease
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Chronic Obstructive Pulmonary Disease
Lead sponsor: Universitair Ziekenhuis Brussel
Sponsor class: OTHER
Collaborators: name: Vrije Universiteit Brussel
First posted: 2019-02-25
Enrollment: 50
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: COPD patients

Brief summary: This study will assess the within-day variation of blood eosinophils in patients with Chronic Obstructive Pulmonary disease (COPD) in stable state and determine if there is a correlation between the blood eosinophils and certain clinical parameters.

Detailed description: COPD is a heterogeneous disease, resulting in different phenotypes with varying clinical and pathophysiological characteristics. One of these pathophysiological features is chronic airway inflammation which can be eosinophilic of nature. Blood eosinophils could be an accessible biomarker for this eosinophilic inflammation.

Eosinophil counts can fluctuate due to their short half-life in blood and due to a diurnal rhythm. More needs to be known about this diurnal rhythm and the different confounding factors and sources of within-subject variability of this biomarker.

Eligibility criteria: Inclusion Criteria:

* Patients willing and able to give informed consent for participation in the study.
* Age 18 years or older.
* Diagnosis of COPD according to GOLD (Global Initiative for Chronic Obstructive Lung Disease): post-bronchodilator Tiffeneau index \<0.7), in a stable state of the disease.
* A smoking history of \>10 pack-years

Exclusion criteria:

* Clinical diagnosis of asthma.
* Use of systemic corticosteroids (oral, intravenous or infiltration) up to six weeks before inclusion.
* Pregnancy.
* A recent exacerbation of COPD (\<4 weeks).

Primary outcomes:
measure: Within-day within-subject level changes of blood eosinophils
timeFrame: 12 hours
Secondary outcomes:
Other outcomes:
Locations:
city: Brussels
country: Belgium
facility: Universiatir Ziekenhuis Brussel
Study officials:
affiliation: Vrije Universiteit Brussel
name: Ines Van Rossem, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT05132842: Cannabis Use Patterns Among Cancer Patients
Official title: Determining Patterns of Cannabis Use Among Cancer Patients
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Hematopoietic and Lymphoid Cell Neoplasm
Malignant Solid Neoplasm
Lead sponsor: Thomas Jefferson University
Sponsor class: OTHER
Collaborators: name: National Cancer Institute (NCI)
First posted: 2021-11-24
Enrollment: 1568
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: OTHER
Time perspective: CROSS_SECTIONAL
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Patients who had at least one medical or radiation oncology appointment within last 3 years at Sidney Kimmel Cancer Center (SKCC) cancer centers

Brief summary: This study determines patterns of cannabis use among cancer patients. Information collected in this study may help doctors to understand patient use of cannabis therapy, their knowledge and experiences with this therapy, benefits and risks associated with its use, and whether or to what extent they are discussing it with their health care providers.

Detailed description: PRIMARY OBJECTIVES:

I. To identify the frequency, modes, and duration of cannabis use, assess experiences with obtaining and using cannabis, as well as reasons for use and perceived risks and benefits of its use among cancer patients who are undergoing or have recently completed active treatment.

Ia. To uncover disparities in use of cannabis, perceptions of use, and communication with providers among cancer patients who are identify as racial and ethnic minorities, have low health or digital literacy, are of older age or low socioeconomic status.

II. Among cancer patients with a known medical marijuana certification, assess the impact of cannabis on pain management, anxiety, anorexia, and quality of life, as well as their communication with their oncology team about their procurement and use of cannabis.

OUTLINE:

Patients complete a survey about knowledge and awareness of medical cannabis, perceived risks and benefits of cannabis, mode and frequency of use (if applicable), impact on cancer-related symptoms, patient provider discussions about cannabis, and demographic characteristics including health and digital literacy.

Eligibility criteria: Inclusion Criteria:

* Provide signed and dated informed consent form
* English speaking
* Willing to comply with all study procedures and be available for the duration of the study
* Any individual \>= 18 years old
* At least one medical or radiation oncology appoint within the last 3 years at one of the SKCC cancer center campuses

Exclusion Criteria:

* Non-English speaking
* Not a cancer patient at one of the SKCC campuses
* Deceased

Primary outcomes:
measure: Survey data analysis
timeFrame: Up to 12 months
Secondary outcomes:
Other outcomes:
Locations:
city: Philadelphia
country: United States
facility: Thomas Jefferson University Hospital
state: Pennsylvania
Study officials:
References:
Clinical trial NCT02470442: Desflurane in Children With Laryngeal Mask Airway
Official title: Sevoflurane Vs. Sevoflurane-desflurane Anesthesia in Children With Laryngeal Mask Airways; Difference in Respiratory Event, Recovery Time and Emergence Agitation
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Desflurane Anesthesia
Lead sponsor: Seoul National University Hospital
Sponsor class: OTHER
First posted: 2015-06-12
Enrollment: 200
Sex: ALL
Minimum age (years): 2
Maximum age (years): 6
Standard ages: CHILD
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: PREVENTION

Brief summary: The purpose of this study is to characterize the airway responses to desflurane during maintenance of and emergence from anesthesia in children whose airways were supported with laryngeal mask airways (LMAs).


Eligibility criteria: Inclusion Criteria:

* scheduled for elective surgery under general anesthesia with laryngeal mask airway

Exclusion Criteria:

* history of reactive airways disease with an acute exacerbation within the past 2 weeks
* if wheezing or an active upper respiratory infection was present on the day of surgery
* if there was a history of malignant hyperthermia
* a history of moderate-to-severe hepatic dysfunction following anesthesia with desflurane not otherwise explained.

Primary outcomes:
measure: respiratory adverse events
timeFrame: participants will be followed for postoperative period, an expected average of 30 minutes.
Secondary outcomes:
measure: emergence agitation
timeFrame: 15 minutes after arrival on PACU
Other outcomes:
Locations:
city: Seoul
country: Korea, Republic of
facility: Seoul national university hospital
Study officials:
affiliation: Seoul National University Hospital
name: JinTae Kim, MD. PhD.
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT02651142: Sentinel Lymph Node Biopsy With or Without Para-Sentinel Lymph Node Dissection in Breast Cancer
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Breast Cancer
Lead sponsor: Shandong University
Sponsor class: OTHER
First posted: 2016-01-08
Enrollment: 200
Sex: FEMALE
Minimum age (years): 18
Maximum age (years): 75
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: Sentinel lymph node biopsy（SLNB） is an established way of predicting axillary nodal metastasis in early breast cancer. We aim to determinethe，in a prospective randomized, controlled trial, effect of sentinel lymph node biopsy with para-sentinel lymph node(SLN) dissection versus sentinel lymph node biopsy without para-sentinel lymph node dissection on outcomes after breast surgery.

Detailed description: Aim: Compare the disease-free survival (DFS) and overall survival (OS) of breast cancer patients who are randomized to receive sentinel lymph node biopsy with para-sentinel lymph node dissection group vs. those receive only sentinel lymph node biopsy without para-sentinel lymph node dissection

Outline:

Patients are randomized assigned to the following one of two groups and are followed annually.

Arm I: Patients receive sentinel lymph node biopsy with para-sentinel lymph node dissection Arm II: Patients receive only sentinel lymph node biopsy without para-sentinel lymph node dissection

Eligibility criteria: Inclusion Criteria:

1. histologically confirmed primary breast cancer by core needle biopsy or excisional biopsy
2. abnormal para-sentinel lymph node was found by ultrasound examination
3. ultrasound-guided fine needle aspiration cytology of these nodes were performed
4. the result of fine needle aspiration cytology was negative (no tumour cell was found)
5. patient planed to perform SLNB

Exclusion Criteria:

1. pathological diagnosed ductal carcinoma in situ by excisional biopsy
2. the result of fine needle aspiration cytology was positive
3. patient has received neo-adjuvant system therapy

Primary outcomes:
measure: Disease free survival
timeFrame: Up to 10 years
Secondary outcomes:
measure: Overall survival
timeFrame: Up to 10 years
Other outcomes:
Locations:
city: Jinan
country: China
facility: Qifeng Yang
state: Shandong
Study officials:
References:
citation: Ma X, Wen S, Liu B, Li D, Wang X, Kong X, Ma T, Jiang L, Yang Q. Relationship between Upper Extremity Lymphatic Drainage and Sentinel Lymph Nodes in Patients with Breast Cancer. J Oncol. 2019 Apr 1;2019:8637895. doi: 10.1155/2019/8637895. eCollection 2019.
citation: Li X, Chen S, Jiang L, Kong X, Ma T, Xu H, Yang Q. Precise intraoperative sentinel lymph node biopsies guided by lymphatic drainage in breast cancer. Oncotarget. 2017 Jun 27;8(38):63064-63072. doi: 10.18632/oncotarget.18624. eCollection 2017 Sep 8.
Clinical trial NCT01592942: Mesh Fixation in Lichtenstein Hernioplasty
Official title: A Randomized Multi-center Study of Tissue Glue Fixation of Optilene™ Mesh With Histoacryl™ or Self-gripping Parietex ProGrip™ Compared to Conventional Non-absorbable Suture Fixation of Ultrapro™ Mesh
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Inguinal Hernia
Keywords: inguinal hernia
mesh fixation
glue
Lichtenstein
Lead sponsor: Kuopio University Hospital
Sponsor class: OTHER
Collaborators: name: Helsinki University Central Hospital
name: Paijat-Hame Hospital District
name: North Karelia Central Hospital
name: East Savo Hospital District
First posted: 2012-05-07
Enrollment: 650
Sex: ALL
Minimum age (years): 18
Maximum age (years): 80
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: This is a prospective, randomized multi-centre study to find out most safe, feasible, painless and cost-effective mesh fixation method in inguinal hernia operation. Three mesh fixation techniques are compared to find out best technique in local anaesthesia Lichtenstein operation. Our hypothesis is that glue fixation is safe, simple and cheap method compared to conventional Lichtenstein technique.

Detailed description: Some 650 patients with inguinal hernia are operated using Lichtenstein operation in local anaesthesia. Mesh fixation is performed using 3 methods: Optilene™ mesh + cyanoacrylate glue (n=200), self-fixing Parietex Progrip™ mesh (n=200) and non-absorbable sutures with Ultrapro™ mesh (n=200). Operative time and pain scores, immediate postoperative outcome, quality-of-life and total costs are followed 1, 7, 30 days and 1 and 5 years postoperatively.

Eligibility criteria: Inclusion Criteria:

* primary or recurrent inguinal hernia
* unilateral or bilateral

Exclusion Criteria:

* femoral hernia
* massive scrotal hernia
* allergy to polypropylene
* patient's refusal

Primary outcomes:
measure: pain
timeFrame: 5 years
Secondary outcomes:
measure: costs
timeFrame: 1 year
Other outcomes:
Locations:
city: Kuopio
country: Finland
facility: Kuopio University Hospital
Study officials:
affiliation: Kuopio University Hospital
name: Hannu EK Paajanen, MD, PhD
role: PRINCIPAL_INVESTIGATOR
References: