Clinical trial NCT01347099: Internet-based Cognitive Behavior Therapy (CBT) for Obsessive Compulsive Disorder (OCD)
Official title: Internet-based Cognitive Behavior Therapy for Obsessive Compulsive Disorder: A Randomized Controlled Trial
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE2
Conditions: Obsessive Compulsive Disorder
Keywords: CBT
OCD
Internet
Reduce symptom burden
Lead sponsor: Karolinska Institutet
Sponsor class: OTHER
First posted: 2011-05-04
Enrollment: 101
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: Cognitive behavior therapy (CBT) is an effective treatment for obsessive compulsive disorder (OCD) but there is a lack of properly trained CBT therapists. One possible treatment alternative is Internet-based CBT (ICBT) with minimal therapist input. The aim of this study was therefore to evaluate ICBT for OCD.

Detailed description: This is a randomized controlled trial with 101 participants. The control group receives support therapy on demand on the Internet.

Eligibility criteria: Inclusion Criteria:

* Primary diagnosis of obsessive compulsive disorder (OCD)
* At least 18 years old
* Able to read and write in swedish
* Computer access

Exclusion Criteria:

* other primary diagnosis
* substance abuse,
* psychosis,
* bipolar disorder,
* suicidal ideation,
* adjusted pharmacological treatment the last two months
* current psychological treatment for OCD,
* been treated with CBT the last two years,
* serious somatic disease,
* Y---BOCS\>31
* hoarding as primary OCD subtype

Primary outcomes:
measure: Change from Baseline of obsessions and compulsions after 10 weeks and at 3- and 12 months after treatment.
timeFrame: Two weeks before treatment, 10 weeks after treatment starts, 3 and 12 months after treatment has ended
Secondary outcomes:
measure: Change from Baseline of obsessions and compulsions after 10 weeks and at 3- and 12 months after treatment.
timeFrame: Two days before treatment, once per week for 10 weeks after treatment starts, 3 and 12 months after treatment has ended
measure: Change from Baseline of obsessions and compulsions after 10 weeks and at 3- and 12 months after treatment.
timeFrame: Two weeks before treatment, 10 weeks after treatment starts, 3 and 12 months after the treatment has ended
measure: Change from Baseline of depressive symptoms after 10 weeks and at 3- and 12 months after treatment.
timeFrame: Two weeks before treatment, 10 weeks after treatment starts, 3 and 12 months after treatment has ended
measure: Change from Baseline of meta cognitions after 10 weeks and at 3- and 12 months after treatment.
timeFrame: Two weeks before treatment, 10 weeks after treatment starts, 3 and 12 months after treatment has ended
measure: Change from Baseline of quality of life after 10 weeks and at 3- and 12 months after treatment.
timeFrame: Two weeks before treatment, 10 weeks after treatment starts, 3 and 12 months after treatment has ended
Other outcomes:
Locations:
city: Stockholm
country: Sweden
facility: Psykiatri Sydväst
Study officials:
affiliation: Department of Clinical Neuroscience, KI
name: Christian Rück, MD, PhD
role: PRINCIPAL_INVESTIGATOR
References:
citation: Andersson E, Enander J, Andren P, Hedman E, Ljotsson B, Hursti T, Bergstrom J, Kaldo V, Lindefors N, Andersson G, Ruck C. Internet-based cognitive behaviour therapy for obsessive-compulsive disorder: a randomized controlled trial. Psychol Med. 2012 Oct;42(10):2193-203. doi: 10.1017/S0033291712000244. Epub 2012 Feb 21.