louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT05011175: Exercise Habits: A Survey of Individuals With Parkinson's Disease Living in the Community
Official title: Exercise Habits: A Survey of Individuals With Parkinson's Disease Living in the Community
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Parkinson Disease
Keywords: Exercise
Survey
Lead sponsor: University of Kentucky
Sponsor class: OTHER
First posted: 2021-08-18
Enrollment: 138
Sex: ALL
Minimum age (years): 40
Maximum age (years): 90
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Individuals ages 40-90 years old who have been diagnosed with Parkinson's Disease.

Brief summary: This study aims to evaluate the exercise regimens of individuals with Parkinson's.


Eligibility criteria: Inclusion Criteria:

* Diagnosed with Parkinson's Disease
* Able to speak English

Exclusion Criteria:

* No internet access

Primary outcomes:
measure: Age
timeFrame: Reported at baseline
measure: Self-reported age of Parkinson's Disease Diagnosis
timeFrame: Reported at baseline
measure: Self-reported education level
timeFrame: Reported at baseline
measure: Self-reported living situation
timeFrame: Reported at baseline
measure: Self-reported number of years taking medicine for Parkinson's Disease
timeFrame: Reported at baseline
measure: Self-reported brain stimulation treatment
timeFrame: Reported at baseline
measure: Self-reported stage of Parkinson's Disease
timeFrame: Reported at baseline
measure: Self-reported physical help requirement
timeFrame: Reported at baseline
measure: Self-reported walking ability
timeFrame: Reported at baseline
measure: Self-reported mobility level
timeFrame: Reported at baseline
measure: Self-reported current exercise habits survey
timeFrame: Reported at baseline
measure: Perceived levels of intensity
timeFrame: Reported at baseline
Secondary outcomes:
Other outcomes:
Locations:
city: Lexington
country: United States
facility: University of Kentucky
state: Kentucky
Study officials:
affiliation: University of Kentucky
name: Jordana Lockwich, PT, DPT
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT02555059: Special Drug Use Investigation of Ciproxan Injection in Pediatrics
Official title: Special Drug Use Investigation of Ciproxan® Injection in Pediatrics
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Cystitis / Pyelonephritis / Cystic Fibrosis / Anthrax
Keywords: Ciprofloxacin
Japan
Post-marketing surveillance
Lead sponsor: Bayer
Sponsor class: INDUSTRY
First posted: 2015-09-21
Enrollment: 48
Sex: ALL
Maximum age (years): 14
Standard ages: CHILD
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Female and male pediatric patients (less than 15 years old) with a diagnosis of complicated cystitis, pyelonephritis, cystic fibrosis, or anthrax infected by ciprofloxacin-active microorganisms, i.e. Bacillus anthracis, Escherichia coli, Pseudomonas aeruginosa, are enrolled after the decision for treatment with Ciproxan injection has been made by the investigator.

Brief summary: The objective in this study is collecting post-marketing information on the safety and efficacy of Ciproxan injection under the routine clinical practice.

Detailed description: This company-sponsored study is an one-arm, prospective, and, cohort-observational study in pediatrics (less than 15 years old) administered Ciproxan injection. All patients in the contracted institute should be enrolled into this study. Consequently 45 cases will be is planned to be enrolled in three-year period Target population is pediatrics with a diagnosis of complicated cystitis, pyelonephritis, cystic fibrosis, or anthrax infected by ciprofloxacin-active microorganisms, i.e. Bacillus anthracis, Escherichia coli, Pseudomonas aeruginosa. The treatment should be performed based on the product label in Japan. The standard observation will be performed until the last date of the treatment.

Eligibility criteria: Inclusion Criteria:

* Female and male pediatric patients (less than 15 years old) with a diagnosis of complicated cystitis, pyelonephritis, cystic fibrosis, or anthrax infected by ciprofloxacin-active microorganisms, i.e. Bacillus anthracis, Escherichia coli, Pseudomonas aeruginosa.
* Patients for whom the decision to initiate treatment with Ciproxan injection was made as per investigator's routine treatment practice.

Exclusion Criteria:

* N/A

Primary outcomes:
measure: Number of musculoskeletal adverse events.
timeFrame: Up to 12 months
Secondary outcomes:
measure: Existence of Bacillus anthracis or Escherichia coli or Pseudomonas aeruginosa in urine(Y/N)
timeFrame: At week 6
measure: Number of participants with adverse events as measure of safety and tolerability
timeFrame: At week 4
measure: Efficacy
timeFrame: Up to 2 weeks
measure: Number of participants with adverse events based on abnormal laboratory measurements
timeFrame: At week 4
Other outcomes:
Locations:
city: Multiple Locations
country: Japan
Study officials:
affiliation: Bayer
name: Bayer Study Director
role: STUDY_DIRECTOR
References:
Clinical trial NCT01269359: Robotic Assisted Vertebral Body Augmentation - a Radiation Reduction Tool
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Vertebral Body Augmentation
Lead sponsor: Hadassah Medical Organization
Sponsor class: OTHER
First posted: 2011-01-04
Enrollment: 100
Sex: ALL
Minimum age (years): 18
Maximum age (years): 85
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: men and women that are candidates to vertebral body augmentation

Brief summary: Modern orthopedic and spine surgeons strive towards minimizing surgical exposure and towards increased precision in the placement of implants. This trend requires an increased use of fluoroscopic guidance, which leads to increased exposure of the patient, surgeon and the operating room staff to radiation.

Robotic assisted spine surgery is routinely performed in the authors' institution for a variety of indications such as degenerative conditions, trauma, tumors , infections and deformity correction11. The objective of this study is to compare the radiation exposure time during robotic guided vertebral body augmentation to the published results for similar surgeries.


Eligibility criteria: Inclusion Criteria:

* Men and Women
* Ages 18-85

Exclusion Criteria:

* Unwillingness to participate the study

Primary outcomes:
measure: amount of radiation
Secondary outcomes:
Other outcomes:
Locations:
city: Jerusalem
country: Israel
facility: Hadassah Medical Organizaton
Study officials:
References:
Clinical trial NCT00889759: The Role of High Resolution-Computed Tomography (CT) in Tuberculosis (TB) Outbreak Investigation
Official title: The Role of Addition of High Resolution-CT in Outbreak Investigation of Tuberculosis
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Tuberculosis
Keywords: Tuberculosis
Outbreaks
Lead sponsor: Armed Forces Capital Hospital, Republic of Korea
Sponsor class: OTHER_GOV
First posted: 2009-04-29
Enrollment: 92
Sex: MALE
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: A military unit in South Korean Army

Brief summary: The aim of this study is to evaluate the role of high-resolution computed tomography of the chest (HRCT) in the investigation of an outbreak of TB that developed in the South Korean army.

Detailed description: Outbreak investigation including tuberculin skin test (TST), QuantiFERON® TB Gold In-Tube (QFT), and simple chest radiography (CXR) will be performed. For participants with any abnormal findings in these tests, HRCT will be carried out. Active pulmonary TB is diagnosed based on sputum studies or HRCT findings. In addition, participants with positive results both in TST and QTF will be treated as having a latent TB infection (LTBI). TST and QTF were repeated in participants with positive result in one of these tests. CXR will be repeated in all participants at 3 and 6 months of follow-up.

Eligibility criteria: Inclusion Criteria:

* All soldiers who assigned to the military battery where a tuberculosis outbreak occurred

Exclusion Criteria:

* Soldiers who could not complete study

Primary outcomes:
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
affiliation: Seoul National University Hospital
name: Jae-Joon Yim, MD
role: PRINCIPAL_INVESTIGATOR
References:
citation: Lee SW, Jang YS, Park CM, Kang HY, Koh WJ, Yim JJ, Jeon K. The role of chest CT scanning in TB outbreak investigation. Chest. 2010 May;137(5):1057-64. doi: 10.1378/chest.09-1513. Epub 2009 Oct 31.
Clinical trial NCT04658459: Results of the Tactys Implant in Proximal Interphalangeal Joint Arthroplasty
Official title: Proximal Interphalangeal Joint Arthroplasty With the TACTYS® Prosthesis : Clinical and Radiographic Results at Medium Term.
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Interphalangeal; Osteoarthritis, Proximal (Bouchard)
Keywords: tactys prosthesis
Lead sponsor: Central Hospital, Nancy, France
Sponsor class: OTHER
First posted: 2020-12-08
Enrollment: 100
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: RETROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: patients who have undergone a proximal interphalangeal joint arthroplasty with the Tactys prosthesis between january 2015 and january 2020 in the Chirugie de la main service in the Centre chirurgical Emile Gallé in Nancy

Brief summary: Study at middle term of the functional and radiographic results of proximal interphalangeal joint arthroplasty with the Tactys prothesis. The aim is to evaluate if the short term results are maintained in time.

Detailed description: The inclusion criteria is any patient who has undergone a proximal interphalangeal joint arthroplasty with the Tactys prothesis between january 2015 to january 2020 in the Centre Chirurgical Emile Gallé in Nancy.

The functional results evaluated are range of motion, force, pain, functional score as Quick DASH and the radiological one are clinodactyly, periprosthetic ossifications and loosening, dislocation and implant subsidence.

Data is registered from the medical folder of every patient.

Eligibility criteria: Inclusion Criteria:

* one or more proximal interphalangeal joint arthroplasty of long fingers with the Tactys prosthesis
* between january 2015 to january 2020
* major
* centre chirurgical emile gallé, centre hospitalier régional universitaire de Nancy

Exclusion Criteria:

* minor

Primary outcomes:
measure: range of motion in degrees
timeFrame: minimal one year post-operative
measure: force in kilograms
timeFrame: minimal one year post-operative
measure: pain with the digital pain scale
timeFrame: minimal one year post-operative
measure: functional score with the Quick DASH
timeFrame: minimal one year post-operative
Secondary outcomes:
measure: register the complication and their apparition in time
timeFrame: minimal one year post-operative
measure: assess satisfaction
timeFrame: minimal one year post-operative
Other outcomes:
Locations:
city: Nancy
country: France
facility: Centre Hospitalier Régional Universitaire
state: Meurthe ET Moselle
Study officials:
References:
Clinical trial NCT06952959: The Effects of Cosmetic Acupuncture
Official title: Using Professional Intelligent Skin Analyzers to Analyze the Effects of Cosmetic Acupuncture on Skin Health and Aging: A Randomized Controlled Trial
Study type: INTERVENTIONAL
Overall status: RECRUITING
Phase: NA
Conditions: Aging
Skin Health
Lead sponsor: China Medical University Hospital
Sponsor class: OTHER
First posted: 2025-05-01
Enrollment: 40
Sex: ALL
Minimum age (years): 30
Maximum age (years): 60
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The study recruited 40 subjects and divided them into an intervention group and a waiting list group in a 1:1 ratio using a randomized controlled trial. The changes in skin health and aging-related indicators before and after TCM cosmetic acupuncture treatment were analyzed. The subjects are of all genders and aged between 30 and 60 years old. The TCM cosmetic acupuncture treatment is arranged twice a week for a three-week course. The study will conduct a skin test before and after the TCM cosmetic acupuncture, and use the Antera 3D smart skin detector to comprehensively evaluate the subjects' skin condition. Antera 3D Skin Detector can detect multiple skin indicators, including wrinkle depth, skin tone uniformity and subtle changes in the skin surface, melanin, red pigment, etc. After the treatment, the subjects' acceptance and satisfaction with TCM cosmetic acupuncture were collected.


Eligibility criteria: Inclusion Criteria:

* both female and male
* 30 to 60 years old
* never had acupuncture beauty treatment, or the last time they had acupuncture beauty treatment has been more than six months.

Exclusion Criteria:

* medical cosmetic fillers on their face
* cosmetic surgery
* needle sickness
* afraid of acupuncture
* wounds on the facial skin
* poor wound healing
* abnormal coagulation function
* severe diabetes
* keloids
* dialysis
* cancer patients undergoing chemotherapy or radiotherapy
* pregnant

Primary outcomes:
measure: Face Skin Texture
timeFrame: Intervention group: the 1st, 4th week; waiting list group: the 1st, 4th, and 7th week.
measure: Face Skin Color
timeFrame: Intervention group: the 1st, 4th week; waiting list group: the 1st, 4th, and 7th week.
measure: Face Pore Size
timeFrame: Intervention group: the 1st, 4th week; waiting list group: the 1st, 4th, and 7th week.
Secondary outcomes:
measure: The Questionnaire of satisfaction and acceptance of cosmetic acupuncture
timeFrame: Intervention group: the 4th week; waiting list group: the 7th week.
Other outcomes:
Locations:
city: Taichung
country: Taiwan
facility: China medical university hospital
Study officials:
References:
Clinical trial NCT00801359: BSSPlus Versus Lactated Ringer's for Phacoemulsification
Official title: Comparison of Corneal Changes After Phacoemulsification Using BSSPlus Versus Lactated Ringer's Irrigating Solution
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE2
Conditions: Cataract
Keywords: cataract
phacoemulsification
irrigation solution
endothelial cell density
corneal thickness
Lead sponsor: University of Sao Paulo
Sponsor class: OTHER
First posted: 2008-12-03
Enrollment: 110
Sex: ALL
Minimum age (years): 50
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: Two intraocular irrigating solutions (BSSPlus versus Lactated Ringer's) are compared in this prospective, randomized, masked trial to investigate for differences in preservation of corneal integrity after phacoemulsification cataract surgery.


Eligibility criteria: Inclusion Criteria:

* Patients with senile cataract
* Visual acuity between 20/400 and 20/40

Exclusion Criteria:

* Presence of corneal opacity
* Presence of corneal disease
* Traumatic, toxic, hereditary (congenital)and complicated cataracts(uveitis)
* Anterior chamber cells or flare detected before surgery
* Previous ocular surgery
* Any condition which may affect documentation or follow-up

Primary outcomes:
measure: endothelial cell density
timeFrame: baseline and at 1, 8, 15, 30 and 60 days postoperatively
measure: central corneal thickness
timeFrame: baseline and at 1, 8, 15, 30 and 60 days postoperatively
Secondary outcomes:
measure: number of anterior chamber cells and flare grade
timeFrame: baseline and at 1, 8, 15, 30 and 60 days postoperatively
Other outcomes:
Locations:
city: Ribeirão Preto
country: Brazil
facility: Hospital das Clínicas da Faculdade de Medicina de Ribeirão Preto; Centro Avançado de Retina e Catarata
state: São Paulo
Study officials:
References:
citation: Puckett TR, Peele KA, Howard RS, Kramer KK. Intraocular irrigating solutions. A randomized clinical trial of balanced salt solution plus and dextrose bicarbonate lactated Ringer's solution. Ophthalmology. 1995 Feb;102(2):291-6. doi: 10.1016/s0161-6420(95)31026-3.
citation: McCarey BE, Polack FM, Marshall W. The phacoemulsification procedure. I. The effect of intraocular irrigating solutions on the corneal endothelium. Invest Ophthalmol. 1976 Jun;15(6):449-57.
citation: Joussen AM, Barth U, Cubuk H, Koch H. Effect of irrigating solution and irrigation temperature on the cornea and pupil during phacoemulsification. J Cataract Refract Surg. 2000 Mar;26(3):392-7. doi: 10.1016/s0886-3350(99)00470-8.
citation: Kaye GI, Mishima S, Cole JD, Kaye NW. Studies on the cornea. VII. Effects of perfusion with a Ca++-free medium on the corneal endothelium. Invest Ophthalmol. 1968 Feb;7(1):53-66. No abstract available.
citation: Rosenfeld SI, Waltman SR, Olk RJ, Gordon M. Comparison of intraocular irrigating solutions in pars plana vitrectomy. Ophthalmology. 1986 Jan;93(1):109-15. doi: 10.1016/s0161-6420(86)33790-4.
Clinical trial NCT03693859: Smart Gaming in Obesity
Official title: Smart Gaming for Obesity: A Randomized Trial
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Obesity
Lead sponsor: Philadelphia College of Osteopathic Medicine
Sponsor class: OTHER
Collaborators: name: National Institutes of Health (NIH)
First posted: 2018-10-03
Enrollment: 200
Sex: ALL
Minimum age (years): 18
Maximum age (years): 65
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: Obesity (Body Mass Index ≥ 30 kg/m2) is associated with diminished executive functioning. The primary objective of this randomized, controlled trial is to evaluate the efficacy of a behavioral weight loss program coupled with enhanced executive functioning training via serious gaming on weight loss and weight loss maintenance in adults with obesity and executive functioning deficits compared to adults undergoing standard behavioral treatment alone (N = 200). Serious gaming interventions that target the specific cognitive functions needed for weight-loss maintenance may improve long-term weight-loss success.

Detailed description: This randomized, controlled study will evaluate the efficacy of a behavioral weight loss program coupled with enhanced executive functioning training via serious gaming (BWL+GAMING) on weight loss and maintenance in adults with obesity and executive functioning deficits compared to standard behavioral treatment alone (BWL) at two urban Philadelphia university-based clinics (PCOM \[Philadelphia College of Osteopathic Medicine\] and Temple University). Participants will be recruited from the community. All participants (N = 200) will complete 12 weeks of behavioral weight loss treatment. Intervention participants will also complete 30-minutes (5 days per week for 8 weeks) of a serious gaming program, which will feature online games developed specifically to enhance executive functions. The primary outcomes are weight change and weight change maintenance, which will be measured at 12 and 52 weeks, respectively. Neuropsychological testing will evaluate the proposed mechanism of action, changes in executive functioning, before and after treatment (12 and 52 weeks).

Eligibility criteria: Inclusion Criteria:

* Obesity
* Executive functioning deficits
* Internet access

Exclusion Criteria:

* Under 18 years of age
* Over 65 years of age
* Taking weight loss medication
* Pregnant

Primary outcomes:
measure: Weight change
timeFrame: 52 weeks
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
References:
Clinical trial NCT03981159: Effect of Exercise Training in Alzheimer's Patients
Official title: Effect of Exercise Training on Biochemical and Gait/Balance Parameters in Alzheimer's Patients
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Alzheimer Disease
Lead sponsor: University of Genova
Sponsor class: OTHER
First posted: 2019-06-10
Enrollment: 20
Sex: ALL
Minimum age (years): 80
Maximum age (years): 90
Standard ages: OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Intervention model description: Non-pharmacological interventional study
Primary purpose: SUPPORTIVE_CARE

Brief summary: The objective of this study was to examine the effects of exercise training on physical function and biochemical markers in elderly Alzheimer's disease patients.

Detailed description: Alzheimer's disease is a neurodegenerative disease characterized by progressive and irreversible degeneration of nerve cells. The loss of these cells leads to the continuous decline in muscle function with alterations in biochemical and haematological parameters. The objective of this study was to examine the effects of exercise training on physical function and biochemical markers in elderly Alzheimer's disease patients.

Eligibility criteria: Inclusion Criteria:

* Subjects with official diagnosis of Alzheimer's disease;
* Subjects with MMSE higher than12.

Exclusion Criteria:

• Subjects with MMSE below 12 (indicating severe dementia and impairment).

Primary outcomes:
measure: Tinetti test
timeFrame: Approximately 10-15 minutes
measure: Berg Balance Scale
timeFrame: Approximately 20 minutes
measure: 6-minute walking test
timeFrame: 6 minutes
measure: Timed up and go test
timeFrame: Approximately 14 seconds
measure: "Walking While Talking" test
timeFrame: Approximately 1 minute
measure: Red blood cell count
timeFrame: Approximately 10-15 minutes
measure: White blood cell count
timeFrame: Approximately 10-15 minutes
measure: Hemoglobin
timeFrame: Approximately 10-15 minutes
measure: Platelet count
timeFrame: Approximately 10-15 minutes
measure: Hematocrit
timeFrame: Approximately 10-15 minutes
measure: Triglycerides
timeFrame: Approximately 10-15 minutes
measure: Cholesterol
timeFrame: Approximately 10-15 minutes
measure: Total bilirubin
timeFrame: Approximately 10-15 minutes
measure: AST (aspartate aminotransferase)
timeFrame: Approximately 10-15 minutes
measure: ALT (alanine aminotransferase)
timeFrame: Approximately 10-15 minutes
measure: Blood pressure
timeFrame: Approximately 10-15 minutes
measure: Creatinine
timeFrame: Approximately 10-15 minutes
measure: Urea
timeFrame: Approximately 10-15 minutes
measure: Glucose
timeFrame: Approximately 10-15 minutes
measure: Sodium
timeFrame: Approximately 10-15 minutes
measure: Calcium
timeFrame: Approximately 10-15 minutes
measure: Potassium
timeFrame: Approximately 10-15 minutes
Secondary outcomes:
Other outcomes:
Locations:
city: Genoa
country: Italy
facility: University of Genova
Study officials:
affiliation: Universita degli Studi di Genova
name: Nicola L Bragazzi, MD, PhD, MPH
role: PRINCIPAL_INVESTIGATOR
References: