louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT06466213: Acute Effects of Three Different Types Single Leg Exercise in Copd
Official title: Acute Effects of Three Different Types Single Leg Exercise in Copd
Study type: INTERVENTIONAL
Overall status: RECRUITING
Phase: NA
Conditions: Exercise
Lead sponsor: Hacettepe University
Sponsor class: OTHER
First posted: 2024-06-20
Enrollment: 45
Sex: ALL
Minimum age (years): 40
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: SUPPORTIVE_CARE

Brief summary: COPD presents not only respiratory symtoms but also vascular or muscle dysfunction. Exercise training is important for aerobic performance increasing. Generally results show exercise training with both lower limb. Increaed arterial stiffness and muscle oxygenation are observed in COPD. One leg exercise result is not enough to highlight these parameters.

Detailed description: Acute Effects of Three Different Types Single Leg Exercise in Copd

single bout high intensity interval training

single bout continuous exercise training single bout resistance training

Eligibility criteria: Inclusion Criteria:

* COPD patients that applied to physiotherapy
* cooperate to test
* no severe ortopedical and neurological disease no severe cardiovascular disease volunteer to study

Exclusion Criteria:

* have an acute exacerbation
* hypoxemia \[PaO2\] \<55 mmHg
* no cooperated to test no volunteer to study having ortophedical and neurological diesase that affecting of tests having severe cardiovascular disease

Primary outcomes:
measure: six minute walk test
timeFrame: beginning, day 1
Secondary outcomes:
measure: cardiopulmonary exercise test
timeFrame: beginning, day 2
measure: single leg extremity test
timeFrame: beginning, day 3
measure: lung function
timeFrame: beginning, day 1
measure: muscle strength (isometric)
timeFrame: beginning day 1
measure: muscle strength (10 repeated max)
timeFrame: beginning, day 1
measure: continous exercise acute (single leg)
timeFrame: beginning day 4
measure: high intensity interval training acute exercise (single leg)
timeFrame: beginning day 5
measure: strength training acute exercise (single leg)
timeFrame: beginning day 4,5,6
measure: muscle oxygenation
timeFrame: beginning day 4,5,6
measure: arterial stifness
timeFrame: beginning day 2,3, 4,5,6
Other outcomes:
Locations:
city: Ankara
country: Turkey
facility: Elif Kocaaga
Study officials:
affiliation: Hacettepe University
name: elif kocaaga, ms
role: PRINCIPAL_INVESTIGATOR
References:
citation: Evans RA, Dolmage TE, Mangovski-Alzamora S, Romano J, O'Brien L, Brooks D, Goldstein RS. One-Legged Cycle Training for Chronic Obstructive Pulmonary Disease. A Pragmatic Study of Implementation to Pulmonary Rehabilitation. Ann Am Thorac Soc. 2015 Oct;12(10):1490-7. doi: 10.1513/AnnalsATS.201504-231OC.
Clinical trial NCT06217913: Effects of Monitoring Blood Pressure During Pregnancy
Official title: Effects of Monitoring Blood Pressure in High-risk Pregnant Women Using a Wearable Device
Study type: INTERVENTIONAL
Overall status: NOT_YET_RECRUITING
Phase: NA
Conditions: Birth Weight
Weight Gain Trajectory
Lead sponsor: Xinhua Hospital, Shanghai Jiao Tong University School of Medicine
Sponsor class: OTHER
First posted: 2024-01-23
Enrollment: 400
Sex: FEMALE
Minimum age (years): 18
Maximum age (years): 60
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: SUPPORTIVE_CARE

Brief summary: In this study, at least 400 women with high-risk of pregnancy hypertension will use a wearable device to monitor the blood pressure during gestational age from 12 weeks to 28weeks. The observed outcomes including maternal and offspring. Participants were from three hospital including Shanghai Xinhua Hospital, Jiaxing Maternal and Child Health Hospital and Peking University Third Hospital. Pregnant women were randomly divided into control group (routine delivery examination group) and intervention group (routine delivery examination group + use of wearable blood pressure monitoring device group), 200 cases each.


Eligibility criteria: Inclusion Criteria:

* Women with a single pregnancy before 12 weeks of pregnancy
* The presence of any of the following risk factors: age \> 30 years, a history of eclampsia, a family history of eclampsia, obesity (BMI ≥ 30 Kg/m2), and a history of gestational hyperglycemia (pregestational type 1 and type 2 diabetes; gestational manifest diabetes and gestational diabetes requiring insulin treatment), preexisting chronic hypertension, kidney disease, and autoimmune diseases such as systemic lupus erythematosus and antiphospholipid syndrome.
* Signed the informed consent can be continuously followed up.
* Permanent population living in the study area.
* All subjects received routine antenatal examination and treatment.

Exclusion Criteria:

* Termination of pregnancy before 20 weeks
* Withdraw from the study
* Lost visitors

Primary outcomes:
measure: Offspring weight change
timeFrame: up to 24 months
Secondary outcomes:
measure: Maternal blood pressure change
timeFrame: 16 weeks
measure: Maternal complications
timeFrame: 28 weeks
measure: Offspring outcomes
timeFrame: up to 24 months
measure: Offspring neurodevelopment
timeFrame: up to 24 months
measure: Offspring perinatal outcomes
timeFrame: up to 24 months
Other outcomes:
measure: metabolomics
timeFrame: 16 weeks
Locations:
city: Shanghai
country: China
facility: Xin Hua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine
state: Shanghai
Study officials:
References:
Clinical trial NCT01111513: The Influence of the Femoral Nerve Block on Quadriceps Strength
Official title: The Influence of the Femoral Nerve Block on the Quadriceps Strength After Total Knee Replacement
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Total Knee Arthroplasty
Keywords: knee surgery
total knee arthroplasty
total knee replacement
ropivacaine
femoral nerve block
Lead sponsor: Hopital de l'Enfant-Jesus
Sponsor class: OTHER
Collaborators: name: Sanofi
First posted: 2010-04-27
Enrollment: 135
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: Total knee replacement is a frequent procedure in Québec's hospitals and the muscular strength of the quadriceps is the best indicator of the patient's functional recovery post surgery. Thus, the importance of the patient's recovery leads to the evaluation of the influence of the femoral nerve block on the muscle strength.

The purpose of the study is to compare the short term and long term recuperation of the quadriceps' motor strength of after a total knee arthroplasty using different types of analgesics such as the continuous femoral nerve block, the single dose femoral nerve block and the systemic analgesic, a patient controlled analgesic pump.


Eligibility criteria: Inclusion Criteria:

* \> 18 years old
* men or women needing an elective total knee replacement surgery

Exclusion Criteria:

* unicompartmental arthroplasty
* revision surgery for knee arthroplasty
* previous surgery on same knee
* previous fracture of femur/patella with functional after-effects
* allergies or contraindication to any medication used during study or to local anaesthesia technique
* preexisting neurological deficit
* severe anomaly of intracardiac conduction
* previous vascular surgery near the site of introduction of the catheter
* pregnancy or breastfeeding
* ASA IV or V14 class
* Men or women \> 18 years old unfit to consent
* \< 18 years old
* Refusal to sign consent form

Primary outcomes:
measure: Quadriceps strength measurement with Cybex machine
timeFrame: 6 weeks after surgery
measure: Quadriceps strength measurement with Cybex machine
timeFrame: 6 months after surgery
measure: Quadriceps strength measurements with Cybex machine
timeFrame: 12 months after surgery
Secondary outcomes:
measure: Overall functional recovery
timeFrame: 6 weeks after surgery
measure: Pain score on Visual Analog Scale (VAS)
timeFrame: every 6 hour for the 48 hours following surgery
measure: Hospital stay length
timeFrame: 4 to 7 days after surgery
measure: Overall functional recovery
timeFrame: 6 months after surgery
measure: Overall functional recovery
timeFrame: 12 months after surgery
Other outcomes:
Locations:
city: Québec
country: Canada
facility: CHA-Pavillon Enfant-Jésus
state: Quebec
Study officials:
affiliation: Hôpital Enfant-Jésus
name: Stéphane Pelet, MD, PhD
role: PRINCIPAL_INVESTIGATOR
affiliation: Hôpital Enfant-Jésus
name: Michèle Angers, PhD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT06956313: Hydraulic Pressure Lateral Sinus Lift Approach
Official title: Hydraulic Pressure Sinus Lift Versus Piezoelectric Lift Via Lateral Approach: A Randomized Controlled Clinical Trial.
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Sinus Lifting
Piezoelectric Technique
Keywords: advanced intelligence drill
Sinus lift
hydraulic pressure sinus lift
external sinus lift,
piezoelectric surgery
lateral approach
Lead sponsor: Alexandria University
Sponsor class: OTHER
First posted: 2025-05-04
Enrollment: 20
Sex: ALL
Minimum age (years): 20
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: the study aims to assess the effectiveness of hydraulic pressure sinus lift via lateral wall approach, versus piezoelectric surgery in patients with deficient posterior maxilla.

Detailed description: This study involves a randomized clinical trial of 20 participants with less than 6 mm bone height in the posterior maxilla in need of Maxillary Sinus Floor Augmentation using the lateral window approach. Patients will be randomly assigned to two groups; the HPLT Group which include 10 patients who will undergo hydraulic pressure for osteotomy preparation for lateral sinus lifting technique, and the PSLT Group which include 10 patients managed using piezoelectric surgery. Clinical and radiographic assessment of bone augmentation, as well as intraoperative biological complications and postoperative complications were recorded.

Eligibility criteria: Inclusion Criteria:

* The study included patient with deficient posterior maxilla with less than 6mm of bone height conﬁrmed by a pre-operative tomographic scan. All healthy (ASA I, II) non- smoker patients were eligible for the study. The absence of uncontrolled diabetes, systemic illnesses, sinusitis, immune deficiency disorders, were also required for inclusion.

Exclusion Criteria:

* Patients with sinus infection, neoplasm or a large cyst of the sinus, or those who previously underwent a Caldwell-Luc surgery for the same surgical site were excluded

Primary outcomes:
measure: radiographic appraisal of gain in alveolar bone height
timeFrame: 6 months
Secondary outcomes:
measure: incidence of membrane perforation
timeFrame: Until the end of the operation
Other outcomes:
Locations:
city: Alexandria
country: Egypt
facility: Faculty of Dentistry, Alexandria University
Study officials:
References:
Clinical trial NCT04570813: Art'Health: Effects of Artistic and Participative Workshops at the MAMAC of Nice on the Health of Seniors
Official title: Art'Health: Effects of Artistic and Participative Workshops at the MAMAC of Nice on the Health of Seniors
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Well Aging
Lead sponsor: Centre Hospitalier Universitaire de Nice
Sponsor class: OTHER
First posted: 2020-09-30
Enrollment: 127
Sex: ALL
Minimum age (years): 65
Standard ages: OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: OTHER

Brief summary: Study with two arms, one of which receives an intervention in the form of participative artistic workshops at the MAMAC and the other was assigned as the control group. Well-being, Quality of life, Health, Apathy and Olfactory identification scales are proposed before the intervention, during the intervention at the end of each month (M1, M2, M3), 6 months after the end of the intervention (M9) and 12 months after the end of the intervention (M15).


Eligibility criteria: Inclusion Criteria:

1. Be 65 years of age at the time of signing the consent,
2. Having internet access and an electronic tool (smartphone and/or tablet) at home as repeated assessments will be proposed on a dedicated and secure internet platform,
3. To master the French language,
4. To be available during participatory workshop sessions at MAMAC.
5. Be affiliated to Social Security

Exclusion Criteria:

1. Do not master the French language,
2. Severe sensory and/or cognitive impairment identified by the IP and their representatives during the inclusion interview,
3. Person under guardianship, curatorship or safeguarding of justice,
4. Person unable to give or sign consent.

Primary outcomes:
measure: changes of well being level
timeFrame: before the intervention, during the intervention at the end of each month (Month1, Month 2, Month 3), 6 months after the end of the intervention (Month 9) and 12 months after the end of the intervention (Month 15)
Secondary outcomes:
Other outcomes:
Locations:
city: Nice
country: France
facility: Centre Mémoire de Ressources et de Recherche, CHU de Nice
Study officials:
affiliation: Research and Resources Memory Centre, Nice University Hospital, Nice, France
name: Auriane GROS
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT00153413: West Virginia WISEWOMAN Pilot Study to Test a Brief Nutrition Intervention
Official title: West Virginia WISEWOMAN Pilot Study to Test a Brief Nutrition Intervention
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Heart Disease
Blood Pressure
Obesity
Lead sponsor: Centers for Disease Control and Prevention
Sponsor class: FED
First posted: 2005-09-12
Enrollment: 150
Sex: FEMALE
Minimum age (years): 40
Maximum age (years): 64
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: SUPPORTIVE_CARE

Brief summary: To provide low-income, under- or uninsured 40- to 64-year-old women with the knowledge, skills, and opportunities to improve diet, physical activity, and other lifestyle behaviors to prevent, delay and control cardiovascular and other chronic diseases.

Detailed description: To test whether a brief, interactive, computer-based nutrition intervention (Cookin' Up Health)impacts various health outcomes

Eligibility criteria: Inclusion Criteria:

* NBCCEDP
* Aged 40-64
* Attends selected rural clinics

Exclusion Criteria:

-

Primary outcomes:
measure: Servings of fruits and vegetables
timeFrame: 3 months
Secondary outcomes:
measure: Ability to read food labels
timeFrame: 3 months
measure: Readiness to eat 5 fruits and vegetables per day
timeFrame: 3 months
measure: Dietary Fat Score
timeFrame: 3 month
Other outcomes:
Locations:
Study officials:
affiliation: Centers for Disease Control and Prevention
name: Julie Will
role: STUDY_CHAIR
References:
citation: Santos L. The impact of nutrition and lifestyle modification on health. Eur J Intern Med. 2022 Mar;97:18-25. doi: 10.1016/j.ejim.2021.09.020. Epub 2021 Oct 17.
Clinical trial NCT01350713: The Counter-irritating Efficacy of Topical Povidone-iodine in Thermal Burns
Official title: Testing the Counter-irritating Efficacy of Topical Povidone-iodine in Thermal Burns; Comparison to Conventional Treatments
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Skin Burns
Keywords: skin
burn
povidone iodine
cold water
Lead sponsor: Meir Medical Center
Sponsor class: OTHER
First posted: 2011-05-10
Enrollment: 280
Sex: ALL
Minimum age (years): 6
Maximum age (years): 18
Standard ages: CHILD
ADULT
Accepts healthy volunteers: yes
Allocation: NON_RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: Skin burns are one of the causes of disability, suffering and death in humans. Anecdotal, uncontrolled studies have shown the efficacy of povidone-iodine ointment in human skin burns, provided the preparation was applied shortly after the exposure to the heat source. The proposed study will conduct a controlled study in which the effect of povidone-iodine ointment will be tested in large group of patients and will be compared with standard cold water treatment.

Detailed description: Skin burns are one of the causes of disability, suffering and death in humans. The current treatment includes application of cold water or other plant origin preparations. However non of these treatments was shown to be efficacious.

Animal studies have demonstrated the pronounced protective effect of povidone-iodine ointment against thermal burns. Moreover, anecdotal, uncontrolled studies in humans have shown the efficacy of povidone-iodine ointment in human skin burns, provided the preparation was applied shortly after the exposure to the heat source. The proposed study will conduct a controlled study in which the effect of povidone-iodine ointment will be tested in large group of patients and will be compared with standard cold water treatment.

Eligibility criteria: Inclusion Criteria:

* skin burns in children

Exclusion Criteria:

* allergy to iodine

Primary outcomes:
measure: prevention of skin lesions caused by exposure to heat source
timeFrame: 1 year
Secondary outcomes:
measure: scar prevention
timeFrame: 1 year
Other outcomes:
Locations:
city: Tel Aviv Region
country: Israel
facility: Sherute Briut Clalit
state: Gush Dan, Heifa, Beer Sheva
Study officials:
affiliation: Sherute Briut Clalit
name: Arieh Bahir, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT03480113: The Effectiveness of Mindfulness-based Intervention on Smoking Cessation
Official title: A Pilot Study of the Effectiveness of Mindfulness-based Intervention on Smoking Cessation: a Workplace Health-promoting Program
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Smoking Cessation
Lead sponsor: Chung Shan Medical University
Sponsor class: OTHER
Collaborators: name: Changhua Christian Hospital
First posted: 2018-03-29
Enrollment: 100
Sex: ALL
Minimum age (years): 20
Maximum age (years): 65
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The present study will carry out a workplace health promotion via MBI to help smoking workers to quit smoking.

Detailed description: The present study will carry out a workplace health promotion via MBI to help smoking workers to quit smoking. The study will adopt a longitudinal research design with randomized quasi-experimental trial. The smoking workers will recruited and be randomly assigned to Group A (one lesson of health education on smoking cessation and six lessons of MBI) or Group B (one lesson of health education on smoking cessation and six lessons of physical fitness). There will be 50 participants in each group. Data will be collected five times.

Eligibility criteria: Inclusion Criteria:

* volunteered employees with heavy smoker
* Full-time paid workers

Exclusion Criteria:

* Age \< 20y or \> 65y
* Part-time workers
* The workers are not willing to take part in the study

Primary outcomes:
measure: Nicotine dependence level
timeFrame: Up to 8 months
Secondary outcomes:
measure: Self-reported stress
timeFrame: Up to 8 months
measure: Psychological distress
timeFrame: Up to 8 months
measure: the Level of mindfulness
timeFrame: Up to 8 months
measure: the level of CO
timeFrame: Up to 8 months
Other outcomes:
Locations:
city: Taichung
country: Taiwan
facility: AIDC
Study officials:
affiliation: Department of Psychology, Chung Shan Medical University
name: Shu-Ling Huang, PhD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT00239213: Catechin Gargling for Influenza Infection
Official title: A Randomized Clinical Study of Catechin Gargling Effects on the Prevention of Influenza Infection
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Influenza Infection
Keywords: catechins
gargling
healthy volunteers
Lead sponsor: University of Shizuoka
Sponsor class: OTHER
Collaborators: name: Shizuoka General Hospital
name: Seirei Hamamatsu General Hospital
name: White Cross Nursing Home
First posted: 2005-10-14
Enrollment: 400
Sex: ALL
Minimum age (years): 20
Maximum age (years): 65
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: PREVENTION

Brief summary: The purpose of this study is to clarify the preventive effects of catechin gargling on the influenza infection.

Detailed description: In-vitro experimental studies have revealed that tea catechin extracts induce preventive effects on influenza infection. However, few studies have been conducted on the effects of tea gargling on influenza infection, and the clinical evidence is unclear. Also there have been no studies reported on the gargling effects with tea catechin extracts on the prevention of influenza infection.

Eligibility criteria: Inclusion Criteria:

* healthy volunteers
* aged 20 to 65 years old
* obtained written informed concent before participation
* inoculated with influenza vaccine before entering the study

Exclusion Criteria:

* other gargling except water during the study
* possessing tea allergy

Primary outcomes:
measure: Incidence rates of influenza infection during the study
Secondary outcomes:
measure: severity of symptoms including complications and hospitalization
Other outcomes:
Locations:
city: Hamamatsu
country: Japan
facility: Seirei Hamamatsu General Hospital
state: Shizuoka
city: Higashi Murayama
country: Japan
facility: White Cross Nursing Home
state: Tokyo
city: Shizuoka
country: Japan
facility: Shizuoka General Hospial
Study officials:
affiliation: University of Shizuoka
name: Hiroshi Yamada, MD, PhD
role: PRINCIPAL_INVESTIGATOR
References: