Clinical trial NCT06768333: Speed of Glucose Absorption During Exercise
Official title: The Need for Speed: Comparing the Speed of Glucose Absorption During Repeated Sprint Cycling
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Healthy Nutrition
Healthy
Lead sponsor: Lancaster University
Sponsor class: OTHER
First posted: 2025-01-10
Enrollment: 10
Sex: ALL
Minimum age (years): 18
Maximum age (years): 40
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: CROSSOVER
Intervention model description: This will be a double-blind randomised crossover design. There will be 1 group of participants who will complete all three conditions at random:

Condition 1 - consume Voom Pocket Rocket. Condition 2 - consume SIS Isotonic Energy Gel. Condition 3 - consume Maurten Gel 160.

Participants will consume each product 35 minutes before starting exercise.

All participants will undergo the same exercise - 5 repeated sprint cycling (cycling against 0.075 kg/ kg body mass) intervals of 15 seconds interspersed with 3 minutes of active recovery.

All participants will have the same measures taken - blood sampling for blood glucose, blood lactate, and electrolytes at the end of each sprint and period of active recovery, and monitoring of gas exchange throughout the exercise.
Primary purpose: BASIC_SCIENCE

Brief summary: The purpose of this study is to look at how fast commercially available supplements containing carbohydrates can get into the bloodstream during repeated sprint cycles. This will build from a pervious study where the investigators tested these supplements on healthy participants during a resting oral glucose tolerance trial. The investigators will be testing three supplements, namely Voom Pocket Rocket, SIS Go Isotonic Energy Gel, and Maurten Gel 160. Each participant will complete all three conditions, consuming one of each supplement at random per condition. The study requires participation from male and female runners, cyclists and triathletes who are aged between 18-40.

Each visit will take approximately 1 hour, and three experimental visits per participant. The study will involve frequent blood sampling and the continuous monitoring of gas exchange (oxygen/carbon dioxide). Blood sampling via cannulation will be used to analyse the lactate, glucose, and electrolyte content of the blood. Gas exchange will measure the oxygen breathed in and carbon dioxide breathed out throughout the exercise.

The investigators plan to carry out the study on 10 participants who will be a mix of male and female runners, cyclists and triathletes.


Eligibility criteria: Inclusion Criteria:

* Aged between 18-40 years
* Male or female
* Tier 2 athletes - local level representation, training \~ 3 times per week, training with a purpose to compete, identify with a specific sport, limited skill development (McKay et al., 2021)

Exclusion Criteria:

* Allergies to any listed ingredients on any supplements.
* Diabetes (type 1 or 2)
* Any medical conditions
* Smokers
* Any injury that would prevent them from exercising
* Anyone using drugs or medication (not including contraception)
* Anyone consuming alcohol within 24 hours of the study
* Exercise must be restricted within 24 hours of the study
* Caffeine must not be consumed within 24 hours of testing as it can significantly enhance carbohydrate oxidation rates (Yeo et al., 2005)
* Diets including high-carbohydrate-low-fat (HCLF), low-carbohydrate-high-fat (LCHF), ketogenic, and/or glycogen manipulation diets (Rauch et al., 2022)

Primary outcomes:
measure: Blood Glucose
timeFrame: Blood glucose measures will be taken 35 minutes after consuming the supplement(s) (baseline), after the 3 minute warmup, and then after every 15 second sprint and every 3 minute period of active recovery
measure: Blood Lactate
timeFrame: Blood lactate measures will be taken 35 minutes after consuming the supplement(s) (baseline), after the 3 minute warmup, and then after every 15 second sprint and every 3 minute period of active recovery
measure: Gas Exchange
timeFrame: Gas exchange will be measured continuously throughout the 20 minutes of exercise, starting at the warmup
Secondary outcomes:
measure: Blood electrolyte content
timeFrame: Blood electrolyte measures will be taken 35 minutes after consuming the supplement(s) (baseline), after the 3 minute warmup, and then after every 15 second sprint and every 3 minute period of active recovery
measure: Rate of Percieved exertion (RPE)
timeFrame: RPE will be measured at the end of the warmup and the end of the final sprint stage
measure: Gastrointestinal (GI) Discomfort Questionnaire
timeFrame: GI Discomfort will be measured 5 minutes before and 5 minutes after exercise
Other outcomes:
Locations:
city: Lancaster
country: United Kingdom
facility: Lancaster University
state: Lancashire
Study officials:
References:
citation: Rauch CE, McCubbin AJ, Gaskell SK, Costa RJS. Feeding Tolerance, Glucose Availability, and Whole-Body Total Carbohydrate and Fat Oxidation in Male Endurance and Ultra-Endurance Runners in Response to Prolonged Exercise, Consuming a Habitual Mixed Macronutrient Diet and Carbohydrate Feeding During Exercise. Front Physiol. 2022 Jan 4;12:773054. doi: 10.3389/fphys.2021.773054. eCollection 2021.