Clinical trial NCT06373900: Wound Closure After Total Knee Arthroplasty: Comparison of Polypropylene and Polyglactin 910 Suture.
Official title: Wound Closure After Total Knee Arthroplasty: Comparison of Polypropylene and Polyglactin 910 Suture. A Randomised Controlled Trial.
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Wound Heal
Wound Dehiscence
Wound Complication
Lead sponsor: Indus Hospital and Health Network
Sponsor class: OTHER
First posted: 2024-04-18
Enrollment: 40
Sex: ALL
Minimum age (years): 50
Maximum age (years): 80
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: HEALTH_SERVICES_RESEARCH

Brief summary: Comparison of wound complication and scar formation in patient undergone bilateral total knee replacement comparison between polypropylene and polyglactin 910 suture. patient randomised according to SNOS protocol into group A and B for their right and left knee closure with each suture. patient followed on 3rd, 7th, 15th and 30th post operative day for wound healing, wound dehiscence and scar formation.

Detailed description: All patients aged 50-80 years, belonging to either sex, diagnosed with end-stage osteoarthritis or post-traumatic arthritis, and scheduled for bilateral primary total knee arthroplasty at the Department of Orthopedics, Indus Hospital and Health Network, Karachi were enrolled in the study. Exclusion criteria included patients having existing skin, neuromuscular, or connective tissue disorders, rheumatoid arthritis, immunosuppression, morbid obesity, and pregnancy. All patients provided voluntary informed written consent before enrolment in the study.

In all patients undergoing primary TKA, one knee was closed using polypropylene, whereas the other was closed with Polyglactin 910 sutures. All surgeries were performed by the same surgical team using a standard medial parapatellar approach. The number of sutures and wound closure techniques were standardized across both groups.

Eligibility criteria: Inclusion Criteria:

* Age 50 to 80 years
* Both gender
* Inform consent
* End stage osteoarthritis

Exclusion Criteria:

* Age less the 50 and more then 80
* BMI more then 40
* Rheumatoid Arthritis
* lack of consent
* Pregnant female

Primary outcomes:
measure: Wound characteristics and complications
timeFrame: 30 days after surgery
measure: Wound Infection Grade
timeFrame: 30 days after surgery
measure: Hollander Cosmetic Wound Evaluation Score
timeFrame: 30 days after surgery
Secondary outcomes:
Other outcomes:
Locations:
city: Karachi
country: Pakistan
facility: Indus Hospital and Health Network
state: Sindh
Study officials:
affiliation: The Indus Hospital and Health Network
name: Nek Mohammad
role: PRINCIPAL_INVESTIGATOR
References:
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