Clinical trial NCT00184418: The Immune System and Psychiatric Disorders
Official title: The Immune System and Psychiatric Disorders
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Stress Disorders, Traumatic
Depressive Disorder
Bipolar Disorder
Personality Disorders
Schizophrenia
Psychotic Disorders
Keywords: Immunity
Immune System
Cytokines
Psychophysiology
Psychoneuroimmunology
Lead sponsor: Norwegian University of Science and Technology
Sponsor class: OTHER
Collaborators: name: St. Olavs Hospital
First posted: 2005-09-16
Enrollment: 1400
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: CROSS_SECTIONAL
Sampling method: PROBABILITY_SAMPLE
Study population: Adults aged 18 years and above. Amitted to psychiatric acute ward of St Olavs Hospital, Trondheim, Norway.

Brief summary: The study is based on a hypothesis that there is interaction between the activity in the immune system and in the mind. To study this, the investigators register different measures for activity in the immune system on patients unselectedly admitted to an acute psychiatric ward. The psychiatric statuses and diagnoses of these patients are carefully defined as well.

Detailed description: Our hypotheses are first that activity in the immune system influences the psychiatric status in general, second that changes in activity in psychiatric status affect activity in the immune system and third that there are connections between certain psychiatric conditions/disorders and certain features of the immune system.

All patients admitted to a psychiatric acute ward covering an area with a population of 130.000 and with around 1000 admittances to an acute psychiatric ward a year (some readmittances) are asked to participate in the study. Patients fill in a question form regarding psychiatric as well as somatic health with emphasis on diseases involving immune activity. When possible also slight information on the family is registered. Both at the time of admittance and after recovery clinical laboratory tests on somatic status are registered. In addition the level of different cytokines is measured. The psychiatric state and precise diagnoses are registered during the stay. The data will be analysed to uncover connections between psychiatric stress in general as well as specific psychiatric diagnoses and activity in the immune system.

Eligibility criteria: Inclusion Criteria:

* Admission to the adult acute psychiatric ward of a certain geographical area during the study period

Exclusion Criteria:

* Patients that do not agree to participate in the study

Primary outcomes:
measure: cytokines
timeFrame: 1 year
Secondary outcomes:
Other outcomes:
Locations:
city: Trondheim
country: Norway
facility: St Olavs Hospital, Department of Psychiatry, Østmarka Hospital
state: Middle Norway
Study officials:
affiliation: St Olavs Hospital/NTNU
name: Solveig K Reitan, MD, PhD
role: STUDY_CHAIR
References:
citation: Saether SG, Schou M, Stoecker W, Teegen B, Borowski K, Vaaler A, Kondziella D, Reitan SK. Onconeural Antibodies in Acute Psychiatric Inpatient Care. J Neuropsychiatry Clin Neurosci. 2017 Winter;29(1):74-76. doi: 10.1176/appi.neuropsych.16050110. Epub 2016 Aug 31.
citation: Schou M, Saether SG, Borowski K, Teegen B, Kondziella D, Stoecker W, Vaaler A, Reitan SK. Prevalence of serum anti-neuronal autoantibodies in patients admitted to acute psychiatric care. Psychol Med. 2016 Dec;46(16):3303-3313. doi: 10.1017/S0033291716002038. Epub 2016 Sep 9.
citation: Sakai Y, Iversen V, Reitan SK. FT4 and TSH, relation to diagnoses in an unselected psychiatric acute-ward population, and change during acute psychiatric admission. BMC Psychiatry. 2018 Jul 28;18(1):244. doi: 10.1186/s12888-018-1819-3.