Clinical trial NCT06505499: Gait Profile Score in Children With Cerebral Palsy (CP): Influence of the CP Type, Treatment With Botulinum Injection and Multilevel Surgery
Official title: Gait Profile Score in Children With Cerebral Palsy (CP): Influence of the CP Type, Treatment With Botulinum Injection and Multilevel Surgery
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Cerebral Palsy
Gait Disorders in Children
Keywords: Cerebral palsy
Gait profile score
Botulinum toxin injection
Multilevel surgery
Lead sponsor: Centre Hospitalier Universitaire de Saint Etienne
Sponsor class: OTHER
First posted: 2024-07-17
Enrollment: 51
Sex: ALL
Minimum age (years): 6
Maximum age (years): 18
Standard ages: CHILD
ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: RETROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Children and adolescents with cerebral palsy treated at the Saint-Etienne University Hospital will be included.

Brief summary: Instrumented three dimensional gait analysis (3DGA) permits to record spatial, temporal, kinetics, kinematics and electromyographic (EMG) parameters in order to understand gait impairment in children and teenagers with cerebral palsy (CP). Nowadays, single-event multilevel surgery in subjects with CP cannot be performed without 3DGA. However, interpretation of multiple and interdependent data remains complex for the clinician. To address this issue, gait statistical index have been developed to give a single measure of the quality of the gait pattern. Among actual index, the Gait Profile Score (GPS), developed by Baker et al (2009), measure the deviation of kinematics parameters from a controlled dataset. The GPS can be divided in nine Gait Variable Score (GVS), corresponding to major lower limb joints: the MAP (Movement Analysis Profile). Many studies have reported the interest of the GPS to analysis gait of subjects with CP: good inter-session reliability, predictor of postoperative kinematic improvement, minimal clinical threshold calculated at 1.6°, significant relationship with clinical data (joint contractures), and sensibility to change after a single-event multilevel surgery.


Eligibility criteria: Inclusion Criteria:

* Etiology of cerebral palsy
* Unilateral, bilateral, triplegic or quadriplegic forms of cerebral palsy.
* 6 to 18 years old
* GMFCS (Gross Motor Function Classification System) I to III
* Instrumented gait analysis of the laboratory of St-Etienne
* Absence of botulinum toxin injection or serial casting in the three months after a first instrumented gait analysis.

Exclusion Criteria:

* Etiology others than cerebral palsy as defined classically (ex: ischemic infarcts in a child older than two years).
* Previous surgery in lower-limb.

Primary outcomes:
measure: Degrees of Gait Profile Score overall
timeFrame: Day 1
Secondary outcomes:
measure: Gait Profile Score right
timeFrame: Month 2
measure: Gait Profile Score left
timeFrame: Year 2
Other outcomes:
Locations:
city: Saint Etienne
country: France
facility: Chu de Saint Etienne
Study officials:
affiliation: CHU de Saint-Etienne
name: Clément BOULARD, physiotherapist
role: PRINCIPAL_INVESTIGATOR
References: