Clinical trial NCT03062306: Chest Compression and Cerebral Oxygenation During Cardiopulmonary Resuscitation
Official title: Can Sufficient Cerebral Oxygenation be Provided in a Synchronized Manner With Chest Compression During Cardiopulmonary Resuscitation?
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Providing Sufficient Cerebral Oxygenation During CPR
Keywords: Cerebral Oxygenation
Cardiopulmonary Resuscitation
Chest Compression
Lead sponsor: Nevsehir Public Hospital
Sponsor class: OTHER_GOV
First posted: 2017-02-23
Enrollment: 20
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: CASE_CONTROL
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: All patients undergoing cardiac arrest in intensive care unit

Brief summary: In recent years, monitorizations during Cardiopulmonary Resuscitation (CPR) are inadequate to show the sufficiency of cerebral oxygenation. During CPR, insufficient chest compressions have critical importance for neurological results and life quality after the return of spontaneous circulation (ROSC).

Detailed description: The Near-Infrared Spectroscopy (NIRS), which is used in measuring the cerebral tissue oxygenation is one of the latest technologies that allow the measurement of brain oxygen saturation. With this study, the issue of whether sufficient cerebral oxygenation is provided during CPR applied to patients that have Cardiac Arrest (CA) will be investigated, and the effect of CPR on the patient prognosis after ROSC will be examined. In this study, the aim is to investigate whether sufficient oxygenation is provided in synchronization with chest compressions during CPR; and to test the regional brain tissue saturation with rSO2 measurement, and the prognosis with Full Outline of UnResponsiveness (FOUR) Score in patients with ROSC.

Eligibility criteria: Inclusion Criteria:

1. All patients undergoing cardiac arrest in intensive care unit

Exclusion Criteria:

1. Head injury and intracranial bleeding
2. Cerebral ischemic vascular event
3. Pulmonary diseases that may affect blood-oxygen levels
4. Below the age of 18

Primary outcomes:
measure: The levels of regional brain tissue oxygen saturation (rSO2) providing with chest compressions during Cardiopulmonary Resuscitation (CPR)
timeFrame: About six month
Secondary outcomes:
measure: Change from baseline in consciousness on Full Outline of UnResponsiveness (FOUR) Score at one week
timeFrame: For a week after ROSC
Other outcomes:
Locations:
city: Nevsehir
country: Turkey
facility: Mehmet Akif YAZAR
Study officials:
References:
citation: Parnia S, Nasir A, Shah C, Patel R, Mani A, Richman P. A feasibility study evaluating the role of cerebral oximetry in predicting return of spontaneous circulation in cardiac arrest. Resuscitation. 2012 Aug;83(8):982-5. doi: 10.1016/j.resuscitation.2012.01.039. Epub 2012 Feb 6.
citation: Kamarainen A, Sainio M, Olkkola KT, Huhtala H, Tenhunen J, Hoppu S. Quality controlled manual chest compressions and cerebral oxygenation during in-hospital cardiac arrest. Resuscitation. 2012 Jan;83(1):138-42. doi: 10.1016/j.resuscitation.2011.09.011. Epub 2011 Sep 28.