louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT03814954: Nebulized Epinephrine vs. Salbutamol in Bronchiolitis Among Children
Official title: Nebulized Epinephrine Versus Nebulized Salbutamol in Bronchiolitis Among Children Aged 1month-24months
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Respiratory Distress Score
Lead sponsor: Makassed General Hospital
Sponsor class: OTHER
First posted: 2019-01-24
Enrollment: 90
Sex: ALL
Minimum age (years): 1
Maximum age (years): 24
Standard ages: CHILD
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: Acute bronchiolitis, mostly secondary to infection due to Respiratory syncytial virus (RSV) is very common in infants under two years old. It is usually benign. However, the dyspnea it causes is a big concern for parents and this disease can take a severe form on certain particular ground thus constituting a frequent reason for hospitalization in pediatrics. Nebulized epinephrine showed more efficacy than nebulized salbutamol.

Detailed description: The objective of this study is to determine if nebulized epinephrine is more efficacious than nebulized salbutamol in all hospitalized children (1 month to 24 months) in treatment of bronchiolitis. A randomized clinical trial which recruits children admitted to the pediatrics department with diagnosis of bronchiolitis. Children aged 1 month to 2 years will be included in the study.

Children who meet the inclusion criteria will be alternately distributed in two groups:

Group 1:

Will receive salbutamol (2 units/kg) with 3 ml normal saline by nebulizer.

Group 2:

Will receive epinephrine (0.5 mg/dose) with 3 ml normal saline by nebulizer. All admitted patients will receive aerosol every 20 minutes three times and after, depending on the clinical status of the patients, they will be given oxygen therapy at 1.5 liters / minute at the admission if oxygen saturation is below 94% till the normalization of the oxygen saturation.

Clinical parameters such as clinical score, oxygen saturation with pulse oximetry, heart rate, and temperature will be measured at admission, at hour 1 to hour 12 and then every 24 hours until they are discharged.

Eligibility criteria: Inclusion Criteria:

* Children diagnosed with acute bronchiolitis.

Exclusion Criteria:

* Children with congenital heart disease or
* chronic lung diseases

Primary outcomes:
measure: Length of stay
timeFrame: 5 days
Secondary outcomes:
measure: Respiratory distress scoring
timeFrame: 5 days
Other outcomes:
Locations:
city: Beirut
country: Lebanon
facility: Makassed General Hospital
Study officials:
affiliation: Makassed General Hospital
name: Mariam Rajab, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT02833454: Study of the Anatomical Direct Insertion Anterior Cruciate Ligament Reconstruction
Official title: Anterior Cruciate Ligament Reconstruction (ACLR) Using Direct Insertion Technique or Traditional Technique With Single and Double Bundle Procedure.
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Rupture of Anterior Cruciate Ligament
Keywords: Anterior Cruciate Ligament Reconstruction
Direct Insertion of Anterior Cruciate Ligament
Lead sponsor: Peking University Third Hospital
Sponsor class: OTHER
First posted: 2016-07-14
Enrollment: 320
Sex: ALL
Minimum age (years): 16
Maximum age (years): 40
Standard ages: CHILD
ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The purpose of the study is to study the effect of anatomical direct insertion ACL reconstruction compared with conventional anatomical ACL reconstruction.

Detailed description: The investigators divide 320 patients with ACL rupture into 4 groups, each group has 80 patients. The operation technique is different among the groups: group A: conventional anatomical double bundle acl reconstruction, group B: conventional anatomical single bundle acl reconstruction, group DA: direct insertion double bundle acl reconstruction, group DSB: direct insertion single bundle acl reconstruction. The investigators compare the results of the patients of each group at 2 years of surgery.

Eligibility criteria: Inclusion Criteria:

* ACL rupture patients aged between 16 to 40 years

Exclusion Criteria:

* combined severe injuries to the operated knee (additional ligament rupture, major meniscus loss, patella instability, cartilage damage \>2°, pathologic leg axis deviation)
* any injury or surgery to the contralateral knee
* any infammatory or systemic disease, neuromuscular disease in the lower limbs, any recent knee infection

Primary outcomes:
measure: Lysholm score of the knee
timeFrame: two years
measure: Tegner score of the knee
timeFrame: two years
measure: IKDC score of the knee
timeFrame: two years
Secondary outcomes:
measure: KT-2000 of the knee
timeFrame: two years
Other outcomes:
Locations:
Study officials:
affiliation: Peking University Third Hospital
name: Jia-Kuo Yu, MD
role: STUDY_CHAIR
References:
Clinical trial NCT04259554: OFC rTMS in Emotionally Unstable and Depressed Patients
Official title: Orbitofrontal Cortex Transcranial Magnetic Stimulation in Patients With Emotionally Unstable Personality Disorder and Depression
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Personality Disorder, Borderline
Personality Disorder; Unstable
Depression
Keywords: rTMS
Lead sponsor: University of Regensburg
Sponsor class: OTHER
First posted: 2020-02-06
Enrollment: 15
Sex: ALL
Minimum age (years): 18
Maximum age (years): 65
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: TREATMENT

Brief summary: Treatment of depression with conventional transcranial magnetic stimulation (rTMS) has shown high evidence using high-frequency left dorsolateral prefrontal cortex (DLPFC) stimulation. Recently, it could be demonstrated that treatment of the right orbitofrontal cortex may be effective in patients who did not respond to conventional DLPFC rTMS. Orbitofrontal cortex (OFC) seem to be involved in the etiopathology of emotionally instable personality disorders. Thus, the present one-arm trial is a pilot study investigating if OFC rTMS is feasable, tolerable and effective.


Eligibility criteria: Inclusion Criteria:

* ICD-10: F60.30 or F60.31
* depressive symptoms and HAMD-21 score of at least 7
* sex: female and male
* residence in Germany and German speaking
* written informed consent

Exclusion Criteria:

* meeting the contraindications for transcranial magnetic stimulation (electric devices or metal implants in the body, e.g. cardiac pace maker, insulin pump)
* neurological disorders (e.g. cerebrovascular events, neurodegenerative disorder, epilepsy, brain malformation, severe head trauma)
* participation in another study parallel to the Trial
* other mental or somatic illness which is not compatible with participation according to the principal investigator
* pregnancy or breastfeeding period
* psychiatric confinement

Primary outcomes:
measure: Hamilton depression rating scale (HDRS)
timeFrame: 4 weeks
Secondary outcomes:
measure: Major Depression Inventory (MDI)
timeFrame: 2 weeks, 4 weeks, 12 weeks
measure: Clinical global impression (CGI)
timeFrame: 2 weeks, 4 weeks, 12 weeks
measure: Depression module of the Patient health questionnaire (PHQ-D)
timeFrame: 4 weeks, 12 weeks
measure: Barratt impulsiveness Scale (BIS)
timeFrame: 4 weeks, 12 weeks
measure: Numeric rating scale of pain
timeFrame: 2 weeks, 4 weeks
measure: nicotine use
timeFrame: 2 weeks, 4 weeks, 12 weeks
measure: Hamilton depression rating scale (HDRS)
timeFrame: 2 weeks, 4 weeks, 12 weeks
measure: Borderline Symptom List (BSL-23)
timeFrame: 2 weeks, 4 weeks, 12 weeks
Other outcomes:
Locations:
city: Regensburg
country: Germany
facility: University of Regensburg
Study officials:
References:
Clinical trial NCT06157554: The Effect of Breathing Exercises in Addition to Conventional Treatment in Frozen Shoulder Patients
Official title: The Effect of Breathing Exercises in Addition to Conventional Treatment on Pain, Normal Joint Movement and Quality of Life in Frozen Shoulder Patients: a Randomized Controlled Trial
Study type: INTERVENTIONAL
Overall status: ACTIVE_NOT_RECRUITING
Phase: NA
Conditions: Frozen Shoulder
Pain
Quality of Life
Lead sponsor: Bandırma Onyedi Eylül University
Sponsor class: OTHER
First posted: 2023-12-06
Enrollment: 40
Sex: ALL
Minimum age (years): 18
Maximum age (years): 65
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The study aimed to investigate the effect of breathing exercises in addition to conventional treatment on pain, normal joint movement and quality of life in patients with frozen shoulder.

A simple random number table will randomly divide participants into two groups. The study group (20 participants) will be given 15 sessions of respiratory exercises in addition to the 15 sessions of physiotherapy provided routinely for treatment. The control group (20 participants) will receive 15 sessions of physiotherapy services in addition to the routine 15 sessions of the physiotherapy department.

Detailed description: After completing the demographic information form, a visual analog scale will be used for pain intensity, a Baseline digital goniometer will be used to measure the normal joint range of the shoulder girdle, and a Short form SF-36 will be used for quality of life. All participants will be evaluated before and after 15 sessions. The same assessments will be performed in both groups. The evaluations are expected to last 40 minutes in total.

The study group (20 participants) will be given 15 sessions of respiratory exercises in addition to the 15 sessions of physiotherapy provided routinely for treatment. The control group (20 participants) will receive 15 sessions of physiotherapy services in addition to the routine 15 sessions of the physiotherapy department.

Eligibility criteria: Inclusion Criteria:

* Being between the ages of 18-65
* Having a diagnosis of a frozen shoulder,
* Volunteering to participate in the study
* Not having any problem that may prevent respiratory exercise.

Exclusion Criteria:

* Not volunteering to participate in the study,
* Having undergone upper extremity surgery,
* History of previous shoulder surgery, shoulder subluxation or dislocation,
* Any mental or sensory problems,
* Acute infection or chronic disease of neurological, psychiatric, orthopedic, cardiological, rheumatological, etc. origin,
* Having any respiratory disease

Primary outcomes:
measure: Visual Analogue Scale
timeFrame: 3 weeks
measure: The Short Form-36 Quality of Life Questionnaire
timeFrame: 3 weeks
measure: Range of motion
timeFrame: 3 weeks
Secondary outcomes:
Other outcomes:
Locations:
city: Balıkesir
country: Turkey
facility: Bandırma Onyedi Eylül University Faculty of Health Sciences Department of Physiotherapy and Rehabilitation
Study officials:
References:
Clinical trial NCT01680354: Surgical Correction of Astigmatism
Official title: Comparative Study of Surgical Laser Correction of Astigmatism
Study type: INTERVENTIONAL
Overall status: WITHDRAWN
Phase: NA
Conditions: Astigmatism
Lead sponsor: Aarhus University Hospital
Sponsor class: OTHER
First posted: 2012-09-07
Enrollment: 0
Sex: ALL
Minimum age (years): 20
Maximum age (years): 50
Standard ages: ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: SINGLE_GROUP
Primary purpose: TREATMENT

Brief summary: Laser correction for myopia and astigmatism using an excimer laser has been performed with success for several years.

During the last 2 years, a new method for correction of refractive errors has emerged. In the method (ReLex) a femtosecond laser is used to cut a lenticule in the corneal stroma that is subsequently removed. For simple myopia this method has proved effective and on par with excimer baser LASIK. However, it remains to be determined if ReLEx is as effective in the treatment of astigmatism.

In the study, patients with high astigmatism are treated with conventional LASIK for astigmatism in one eye and with ReLEx for astigmatism in the other.


Eligibility criteria: Inclusion Criteria:

* Myopic astigmatism between -2.0 and -5.0 diopters
* Maximal difference in spherical equivalent refraction of 2 D between eyes
* No ocular or systemic disease
* Not pregnant or breastfeeding
* Minimum BSCVA of 0.8 (decimal)
* Normal corneal topography
* Sufficient corneal thickness to allow the treatment

Exclusion Criteria:

* Subjects not fulfilling the above criteria

Primary outcomes:
measure: Visual acuity
timeFrame: 1 year
Secondary outcomes:
measure: Refraction
timeFrame: 1 year
Other outcomes:
Locations:
city: Aarhus
country: Denmark
facility: Department of Ophthalmology, Aarhus University Hospital
Study officials:
References:
Clinical trial NCT06074354: Assessing the Use of MY-RIDE, a Just-in-time Adaptive Intervention, to Improve HIV Prevention and Substance Use in Youth Experiencing Homelessness
Official title: Assessing the Use of MY-RIDE, a Just-in-time Adaptive Intervention, to Improve HIV Prevention and Substance Use in Youth Experiencing Homelessness
Study type: INTERVENTIONAL
Overall status: RECRUITING
Phase: NA
Conditions: HIV Infections
Lead sponsor: The University of Texas Health Science Center, Houston
Sponsor class: OTHER
Collaborators: name: National Institute of Nursing Research (NINR)
First posted: 2023-10-10
Enrollment: 450
Sex: ALL
Minimum age (years): 18
Maximum age (years): 25
Standard ages: ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: PREVENTION

Brief summary: The purpose of this study is to determine whether Motivating Youth to Reduce Infections, Disconnections, and Emotion dysregulation (MY-RIDE) decreases substance use , to determine whether MY-RIDE increases human immunodeficiency virus (HIV) prevention strategies and to evaluate MY-RIDE effects on willingness to take Pre-Exposure Prophylaxis (PrEP), stress, substance use urge, and use of mental health and substance use services when compared to attention control youth


Eligibility criteria: Inclusion Criteria:

* have engaged in substance use (alcohol or illicit drugs)
* speak English
* are experiencing homelessness
* engaged in sexual activity in the last 6 months or plan to in the next month
* are not planning to move out of the metro area during the 15-month study period.

Exclusion Criteria:

* Youth Experiencing Homelessness (YEH) who have low literacy based on the Rapid Estimate of Adult Literacy in Medicine-Short Form (scores \< 4)

Primary outcomes:
measure: Change in substance use
timeFrame: baseline, end of intervention (3 months after baseline), 3 months after intervention, 6 months after intervention, and 12 months after intervention
Secondary outcomes:
measure: Change in condom use
timeFrame: baseline, end of intervention (3 months after baseline), 3 months after intervention, 6 months after intervention, and 12 months after intervention
measure: Change in PrEP uptake as assessed by the self reported tool
timeFrame: baseline, end of intervention (3 months after baseline), 3 months after intervention, 6 months after intervention, and 12 months after intervention
measure: Change in sexually transmitted infections (STIs)
timeFrame: baseline, end of intervention (3 months after baseline), 3 months after intervention, 6 months after intervention, and 12 months after intervention
Other outcomes:
Locations:
city: Houston
country: United States
facility: The University of Texas Health Science Center at Houston
state: Texas
Study officials:
affiliation: The University of Texas Health Science Center, Houston
name: Diane M Santa Maria, DrPH, MSN, RN, PHNA-BC, FSAHM
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT01779154: Eosinophilic Gastrointestinal Disorders Patient Registry
Official title: Eosinophilic Gastrointestinal Disorders Patient Registry
Study type: OBSERVATIONAL
Overall status: WITHDRAWN
Conditions: Eosinophilic Esophagitis
Eosinophilic Gastritis
Eosinophilic Enteritis
Eosinophilic Colitis
Keywords: eosinophilic esophagitis
eosinophilic gastritis
eosinophilic enteritis
eosinophilic colitis
Lead sponsor: Arkansas Children's Hospital Research Institute
Sponsor class: OTHER
First posted: 2013-01-30
Enrollment: 0
Sex: ALL
Maximum age (years): 21
Standard ages: CHILD
ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Individuals with a diagnosis of an eosinophilic gastrointestinal disorder

Brief summary: The Eosinophilic Gastrointestinal Disorders (EGIDS) Registry is a longitudinal study that does not involve medical interventions, but serves as a record of demographics, characteristics of disease and treatment, utilization patterns, quality improvement measures and clinical outcomes. The database is proposed so that epidemiologic research can be performed and current and accurate data can be obtained regarding practice patterns, age and gender distributions, efficacy of treatment, clinical outcomes and changes in quality of life.


Eligibility criteria: Inclusion Criteria:

* male or female participants of any race or ethnicity
* age 0 to 21 years
* diagnosis of EGID including: eosinophilic esophagitis, eosinophilic gastritis, eosinophilic enteritis, eosinophilic colitis

Exclusion Criteria:

* hypereosinophilic syndrome
* non-eosinophilic gastrointestinal or allergic disorder

Primary outcomes:
measure: To define characteristics of an eosinophilic gastrointestinal disorder population in a rural southern state
timeFrame: After 12 months of data collection
Secondary outcomes:
Other outcomes:
Locations:
city: Little Rock
country: United States
facility: Arkansas Children's Hospital
state: Arkansas
Study officials:
affiliation: University of Arkansas for Medical Sciences / Arkansas Children's Hospital Research Institute
name: Robbie D Pesek, MD
role: PRINCIPAL_INVESTIGATOR
References:
citation: Pesek RD, Rettiganti M, O'Brien E, Beckwith S, Daniel C, Luo C, Scurlock AM, Chandler P, Levy RA, Perry TT, Kennedy JL, Chervinskiy S, Vonlanthen M, Casteel H, Fiedorek SC, Gibbons T, Jones SM. Effects of allergen sensitization on response to therapy in children with eosinophilic esophagitis. Ann Allergy Asthma Immunol. 2017 Aug;119(2):177-183. doi: 10.1016/j.anai.2017.06.006. Epub 2017 Jul 1.
Clinical trial NCT05207254: Research on the Application of Artificial Intelligence Ultrasonic Recognition Technology in Difficult Airway Assessment
Official title: Research on the Application of Artificial Intelligence Ultrasonic Recognition
Study type: OBSERVATIONAL
Overall status: RECRUITING
Conditions: Difficult Airways
Lead sponsor: Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University
Sponsor class: OTHER
First posted: 2022-01-26
Enrollment: 4000
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: CASE_CONTROL
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: adults who intend to undergo tracheal intubation under general anesthesia

Brief summary: Although there is no related research on the evaluation of difficult airways by ultrasound features based on artificial intelligence, the investigators guess that the evaluation of ultrasound features based on artificial intelligence can make further breakthroughs in difficult airway early warning systems. Therefore, this project intends to use AI technology to extract and analyze the ultrasound features of the subjects, evaluate the correlation between the ultrasound features of the subjects and the occurrence of difficult airways, and construct possible diagnostic models to evaluate AI ultrasound feature recognition in the prediction of difficult airways. The effect and application value of this method are expected to be more intelligent and accurate for early warning of difficult airways in clinical anesthesia.


Eligibility criteria: Inclusion Criteria:

* ASA classification is 1-3
* Patients who intend to undergo tracheal intubation under general anesthesia
* Age ≥ 18 years old

Exclusion Criteria:

* Patients with speech communication and cooperation barriers;
* Patients with open head and neck trauma
* Patients with cervical spine fractures or cervical spine diseases;
* Emergency surgery;
* Patients who are allergic to related drugs.

Primary outcomes:
measure: Diagnosed as a difficult airway
timeFrame: 0-10minutes after intubation
Secondary outcomes:
Other outcomes:
Locations:
city: Shanghai
country: China
facility: Shanghai 9Th Hospital
state: Shanghai
Study officials:
References:
Clinical trial NCT06106854: Medication Adherence in Kidney Transplant Patients: SystemCHANGE™ Results of the Turkish MAGIC Randomized Clinical Trial
Official title: Improving Medication Adherence and Outcomes in Turkish Adult Kidney Transplant Patients Using a Personal Systems Approach: SystemCHANGE™ Results of the Turkish MAGIC Randomized Clinical Trial
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Medication Adherence
Keywords: medication adherence
immunosuppressive medications
adult kidney transplant recipients
nursing
SystemCHANGE
Lead sponsor: Dokuz Eylul University
Sponsor class: OTHER
Collaborators: name: The Scientific and Technological Research Council of Turkey
First posted: 2023-10-30
Enrollment: 42
Sex: ALL
Minimum age (years): 18
Maximum age (years): 80
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: SUPPORTIVE_CARE

Brief summary: The SystemCHANGETM intervention harnesses patients' established daily routines/habits, environment, and important others, as possible solutions that are reoccurring and thus reliable systems that could support medication taking to become a dependable routine/habit. The aim of this study was to evaluate the effect of a six-month SystemCHANGE™ intervention compared to a six-month attention-control education intervention on medication adherence in adult kidney transplant recipients.


Eligibility criteria: The inclusion criteria were patients having only kidney transplantation, aged 18 years or older, taking only immunosuppressant therapy twice daily, not staying in hospital and not diagnosed with a disease shortening their life span. They also were required to own a telephone, use an electronic medication cap and bottle, understand and speak Turkish, and have approval from their nephrologist to participate in the study. They were also assessed in person for cognitive impairment using the Standardized Mini Mental Test. Those who received a 23 or higher score on the test were enrolled in the study sample.

Primary outcomes:
measure: medication adherence
timeFrame: 12-months
Secondary outcomes:
Other outcomes:
Locations:
city: İzmir
country: Turkey
facility: Yaprak Sarıgöl Ordin
Study officials:
References: