Clinical trial NCT06472245: Trial of Therapeutic Cancer Vaccine OSE2101 in Patients With Non-Small Cell Lung Cancer and Secondary Resistance to Immune Checkpoint Inhibitor
Official title: A Randomised, Open-label, Phase 3 Trial Comparing the Efficacy and Safety of OSE2101 Versus Docetaxel in HLA-A2 Positive Patients With Metastatic Non-Small Cell Lung Cancer (NSCLC) With Secondary Resistance to Immune Checkpoint Inhibitor
Study type: INTERVENTIONAL
Overall status: RECRUITING
Phase: PHASE3
Conditions: Patients With Non-Small Cell Lung Cancer
Keywords: Immune Checkpoint Inhibitor
Cancer vaccine
Non-Small Cell Lung Cancer
Lead sponsor: OSE Immunotherapeutics
Sponsor class: INDUSTRY
Collaborators: name: Exystat
name: Genome Diagnostics (GenDx)
First posted: 2024-06-25
Enrollment: 363
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: Multicenter, randomized (2:1), open-label phase 3 study in HLA-A2 positive patients with squamous and non-squamous metastatic NSCLC with ICI secondary resistance.

Patients will be randomized into 2 arms (randomization 2:1): experimental Arm A with OSE2101 monotherapy or control Arm B SoC with docetaxel monotherapy. Stratification factors will be histology (squamous versus non squamous) and ECOG Performance Status (0 versus 1).


Eligibility criteria: Inclusion Criteria:

1. Male or female, aged ≥ 18 years
2. Patients expressing HLA-A2 phenotype in blood by pre-screening central laboratory
3. Patients with histologically or cytologically squamous or non-squamous documented NSCLC, metastatic stage at study entry, not eligible for definite surgery or radiation, without EGFR, ALK and ROS1 gene alterations eligible for targeted therapy; other sensitizing mutations known to be immunosensitive are eligible in case of lack of local access to targeted therapy (i.e.; KRAS G12C and BRAF mutations) after Sponsor's agreement
4. Patients with secondary resistance to ICI;

Other inclusion and exclusion criteria will apply per protocol.

Primary outcomes:
measure: OS defined as time from randomization to death
timeFrame: From randomization date through study completion, an average of 3 years
Secondary outcomes:
Other outcomes:
Locations:
city: Beverly Hills
country: United States
facility: Clinical Research Advisors, LLC
state: California
city: Encino
country: United States
facility: Clinical Research Advisors - Encino
state: California
city: Los Angeles
country: United States
facility: Clinical Research Advisors - West Hollywood
state: California
city: Los Angeles
country: United States
facility: Clinical Research Advisors - Korea Town
state: California
city: Littleton
country: United States
facility: SCL Health - Saint Joseph Hospital Cancer Center
state: Colorado
city: Wheat Ridge
country: United States
facility: Lutheran Medical Center - Cancer Centers of Colorado
state: Colorado
city: Norwich
country: United States
facility: Eastern Connecticut Hematology and Oncology Associates
state: Connecticut
city: Washington
country: United States
facility: Georgetown Lombardi Comprehensive Cancer Center
state: District of Columbia
city: Bradenton
country: United States
facility: Comprehensive Hematology Oncology - Bradenton Clinic
state: Florida
city: Brandon
country: United States
facility: Comprehensive Hematology Oncology - Brandon Clinic
state: Florida
city: Fleming Island
country: United States
facility: Cancer Specialists of North Florida - Fleming Island
state: Florida
city: Jacksonville Beach
country: United States
facility: Cancer Specialists of North Florida
state: Florida
city: Jacksonville
country: United States
facility: Cancer Specialists of North Florida - Riverside
state: Florida
city: Jacksonville
country: United States
facility: Cancer Specialists of North Florida Southside
state: Florida
city: Jacksonville
country: United States
facility: Cancer Specialists of North Florida - Northside
state: Florida
city: Jacksonville
country: United States
facility: Cancer Specialists of North Florida - Southpoint
state: Florida
city: Jacksonville
country: United States
facility: Cancer Specialists of North Florida - Baptist South
state: Florida
city: Largo
country: United States
facility: Comprehensive Hematology Oncology - Largo Clinic
state: Florida
city: Neptune Beach
country: United States
facility: Cancer Specialists of North Florida - Beaches
state: Florida
city: Palm Harbor
country: United States
facility: Comprehensive Hematology Oncology - Palm Harbor Clinic
state: Florida
city: Saint Augustine
country: United States
facility: Cancer Specialists Of North Florida - St. Augustine
state: Florida
city: Saint Petersburg
country: United States
facility: Comprehensive Hematology Oncology - Bayfront Clinic
state: Florida
city: Saint Petersburg
country: United States
facility: Comprehensive Hematology Oncology
state: Florida
city: Trinity
country: United States
facility: Comprehensive Hematology Oncology - Trinity Clinic
state: Florida
city: Chicago
country: United States
facility: University of Illinois Cancer Center
state: Illinois
city: Merriam
country: United States
facility: Alliance for Multispecialty Research (AMR) - Kansas City Oncology
state: Kansas
city: Baton Rouge
country: United States
facility: Mary Bird Perkins Cancer Center - Baton Rouge
state: Louisiana
city: Covington
country: United States
facility: Pontchartrain Cancer Center - Covington Office
state: Louisiana
city: Hammond
country: United States
facility: Pontchartrain Cancer Center - Hammond Office
state: Louisiana
city: Baltimore
country: United States
facility: Ascension Saint Agnes Hospital
state: Maryland
city: Worcester
country: United States
facility: University of Massachusetts Memorial Medical Center
state: Massachusetts
city: Lincoln
country: United States
facility: Nebraska Hematology-Oncology - Revive Research Institute LLC
state: Nebraska
city: Babylon
country: United States
facility: New York Cancer & Blood Specialists - Babylon Medical Oncology
state: New York
city: Brewster
country: United States
facility: Optum Medical Care - Carmel/Brewster Campus
state: New York
city: Bronx
country: United States
facility: New York Cancer & Blood Specialists - Eastchester Cancer Care Center
state: New York
city: Bronx
country: United States
facility: New York Cancer & Blood Specialists - Riverhead Medical Oncology
state: New York
city: Brooklyn
country: United States
facility: Brooklyn Radiation Oncology
state: New York
city: Fishkill
country: United States
facility: Optum Medical Care - Fishkill Westage Campus
state: New York
city: Lake Success
country: United States
facility: Clinical Research Alliance
state: New York
city: Mount Kisco
country: United States
facility: Optum Medical Care - Mount Kisco Campus 90
state: New York
city: New Hyde Park
country: United States
facility: New York Cancer & Blood Specialists - New Hyde Park
state: New York
city: New Hyde Park
country: United States
facility: Optum Hematology Oncology - Lake Success
state: New York
city: New York
country: United States
facility: New York Cancer & Blood Specialists - Cancer Center - Research Headquarters
state: New York
city: New York
country: United States
facility: New York Cancer & Blood Specialists - Central Park Medical Oncology
state: New York
city: Patchogue
country: United States
facility: New York Cancer & Blood Specialists - Patchogue Medical Oncology
state: New York
city: Port Jefferson Station
country: United States
facility: New York Cancer & Blood Specialists - Port Jefferson Medical Oncology
state: New York
city: Port Jefferson Station
country: United States
facility: New York Cancer & Blood Specialists - Port Jefferson Station Medical Oncology
state: New York
city: Poughkeepsie
country: United States
facility: Optum Medical Care - Poughkeepsie
state: New York
city: Perrysburg
country: United States
facility: Mercy Health - Perrysburg Cancer Center
state: Ohio
city: Toledo
country: United States
facility: Mercy Health - St. Anne Cancer Center
state: Ohio
city: Greenville
country: United States
facility: Bon Secours Hematology and Oncology
state: South Carolina
city: Chattanooga
country: United States
facility: Tennessee Oncology - Chattanooga - Medical Park II
state: Tennessee
city: Chattanooga
country: United States
facility: Tennessee Oncology - Chattanooga - Downtown
state: Tennessee
city: Chattanooga
country: United States
facility: Tennessee Oncology - Chattanooga - GHCR Site I
state: Tennessee
city: Chattanooga
country: United States
facility: Tennessee Oncology - Chattanooga - Memorial Plaza
state: Tennessee
city: Cleveland
country: United States
facility: Tennessee Oncology - Cleveland Clinic
state: Tennessee
city: Cookeville
country: United States
facility: Tennessee Oncology - Cookeville Clinic
state: Tennessee
city: Dickson
country: United States
facility: Tennessee Oncology - Dickson Clinic
state: Tennessee
city: Franklin
country: United States
facility: Tennessee Oncology - Franklin Clinic
state: Tennessee
city: Gallatin
country: United States
facility: Tennessee Oncology - Gallatin Clinic
state: Tennessee
city: Hendersonville
country: United States
facility: Tennessee Oncology - Hendersonville Clinic
state: Tennessee
city: Hermitage
country: United States
facility: Tennessee Oncology - Hermitage - Summit Clinic
state: Tennessee
city: Lebanon
country: United States
facility: Tennessee Oncology - Lebanon Clinic
state: Tennessee
city: Murfreesboro
country: United States
facility: Tennessee Oncology - Murfreesboro Clinic
state: Tennessee
city: Nashville
country: United States
facility: Tennessee Oncology - Nashville - Centennial Center for Blood Cancers Clinic
state: Tennessee
city: Nashville
country: United States
facility: Tennessee Oncology - Nashville - Centennial Clinic - Medical Oncology
state: Tennessee
city: Nashville
country: United States
facility: Tennessee Oncology - Nashville - Midtown Center for Blood Cancers
state: Tennessee
city: Nashville
country: United States
facility: Tennessee Oncology - Nashville - St. Thomas Midtown Clinic
state: Tennessee
city: Nashville
country: United States
facility: Tennessee Oncology - Nashville - St. Thomas West Clinic
state: Tennessee
city: Nashville
country: United States
facility: Tennessee Oncology - Nashville - Skyline Clinic
state: Tennessee
city: Nashville
country: United States
facility: Tennessee Oncology - Nashville - Southern Hills Clinic
state: Tennessee
city: Nashville
country: United States
facility: Greco-Hainsworth Tennessee Oncology Centers for Research (GHCR) - Corporate
state: Tennessee
city: Shelbyville
country: United States
facility: Tennessee Oncology - Shelbyville Clinic
state: Tennessee
city: Smyrna
country: United States
facility: Tennessee Oncology - Smyrna Clinic
state: Tennessee
city: Bonney Lake
country: United States
facility: Northwest Medical Specialties - Bonney Lake
state: Washington
city: Federal Way
country: United States
facility: Northwest Medical Specialties - Federal Way
state: Washington
city: Gig Harbor
country: United States
facility: Northwest Medical Specialties - Gig Harbor
state: Washington
city: Puyallup
country: United States
facility: Northwest Medical Specialties - Puyallup Medical Oncology
state: Washington
city: Tacoma
country: United States
facility: Northwest Medical Specialties - Tacoma
state: Washington
city: Brasschaat
country: Belgium
facility: Algemeen Ziekenhuis Klina
state: Antwerpen
city: Leuven
country: Belgium
facility: Universitair Ziekenhuis Leuven - Campus Gasthuisberg
state: Flemish Brabant
city: Hasselt
country: Belgium
facility: Jessa Ziekenhuis - Campus Virga Jesse
state: Limburg
city: Gent
country: Belgium
facility: Algemeen Ziekenhuis Maria Middelares
state: Oost-Vlaaderen
city: Namur
country: Belgium
facility: Centre Hospitalier Universitaire Université Catholique de Louvain Namur - Site Sainte-Elisabeth
state: Wallonia
city: Kortrijk
country: Belgium
facility: Algemeen Ziekenhuis Groeninge - Campus Kennedylaan
state: West-Vlaanderen
city: Roeselare
country: Belgium
facility: Algemeen Ziekenhuis Delta - Campus Rembert Torhout
state: West-Vlaanderen
city: Roeselare
country: Belgium
facility: Algemeen Ziekenhuis Delta - Campus Rumbeke
state: West-Vlaanderen
city: Roeselare
country: Belgium
facility: Algemeen Ziekenhuis Delta - Campus Menen
state: West-Vlaanderen
city: Chicoutimi
country: Canada
facility: Centre Intégré Universitaire de Santé et de Services Sociaux du Saguenay - Lac-Saint-Jean
state: Quebec
city: Montréal
country: Canada
facility: McGill University Health Centre
state: Quebec
city: Rimouski
country: Canada
facility: Centre Intégré de Santé et de Services Sociaux du Bas-Saint-Laurent
state: Quebec
city: Toulon Cedex 9
country: France
facility: Hôpital d'Instruction des Armées Sainte-Anne
state: Alpes-de-Haute-Provence
city: Strasbourg cedex
country: France
facility: Nouvel Hôpital Civil
state: Alsace
city: Marseille cedex 9
country: France
facility: Institut Paoli-Calmettes
state: Bouches-du-Rhône
city: Besançon Cedex
country: France
facility: Centre Hospitalier Régional et Universitaire de Besançon - Hôpital Jean-Minjoz
state: Doubs
city: Brest
country: France
facility: Centre Hospitalier Regional Universitaire Brest - Hopital de la Cavale Blanche
state: Finistère
city: Mulhouse
country: France
facility: Hôpital Emile Muller
state: Grand Est
city: Limoges
country: France
facility: Centre Hospitalier Universitaire Dupuytren 1
state: Haute-Vienne
city: Montpellier
country: France
facility: Hôpital Arnaud de Villeneuve
state: Hérault
city: Bobigny
country: France
facility: Hôpital Avicenne
state: Ile-de-France
city: Créteil
country: France
facility: Centre Hospitalier Intercommunal de Créteil
state: Ile-De-France
city: Paris
country: France
facility: Hôpital Tenon
state: Ile-de-France
city: Rennes cedex 9
country: France
facility: Hôpital Pontchaillou
state: Ille-et-Vilaine
city: Saint-Herblain
country: France
facility: Institut de Cancérologie de l'Ouest - Saint-Herblain - Site René Gauducheau
state: Loire-Atlantique
city: Cholet
country: France
facility: Centre Hospitalier (Ch) De Cholet
state: Maine-et-Loire
city: Toulouse cedex 9
country: France
facility: Hôpital Larrey
state: Midi-pyrenees
city: Marseille
country: France
facility: Hôpital Nord de Marseille
state: Provence Alpes Cote d´Azur
city: Bayonne
country: France
facility: Centre Hospitalier de la Côte Basque
state: Pyrénées-Atlantiques
city: Bron
country: France
facility: Hôpital Louis Pradel
state: Rhone-Alpes
city: Lyon
country: France
facility: Centre Hospitalier Lyon-Sud
state: Rhone-alpes
city: Lyon
country: France
facility: Hôpital de la Croix Rousse
state: Rhone-Alpes
city: La Tronche
country: France
facility: Hôpital Michallon
state: Rhône
city: Villejuif
country: France
facility: Gustave Roussy
state: Val-de-Marne
city: Avignon
country: France
facility: Institut Sainte Catherine
state: Vaucluse
city: Poitiers
country: France
facility: Centre Hospitalier Universitaire de Poitiers
state: Vienne
city: La Roche-sur-Yon
country: France
facility: Centre Hospitalier Départemental Vendée
city: Le Mans
country: France
facility: Centre Hospitalier Le Mans
city: Nantes
country: France
facility: Centre Hospitalier Universitaire De Nantes - Hôpital Nord Laennec
city: Paris
country: France
facility: Groupe Hospitalier Paris Saint-Joseph
state: Île-de-France
city: Paris
country: France
facility: Hôpital Cochin
state: Île-de-France
city: Stuttgart
country: Germany
facility: Robert-Bosch-Krankenhaus
state: Bade-Wurtemberg
city: Heidelberg
country: Germany
facility: Thoraxklinik-Heidelberg
state: Baden-Wuerttemberg
city: Gauting
country: Germany
facility: Asklepios Fachkliniken München-Gauting
state: Bayern
city: München
country: Germany
facility: München Klinik Bogenhausen
state: Bayern
city: Kassel
country: Germany
facility: Klinikum Kassel
state: Hessen
city: Aachen
country: Germany
facility: Universitätsklinikum Aachen
state: Nordrhein-Westfalen
city: Bonn
country: Germany
facility: Universitätsklinikum Bonn
state: Nordrhein-Westfalen
city: Essen
country: Germany
facility: Universitätsklinikum Essen
state: Nordrhein-Westfalen
city: Homburg
country: Germany
facility: Universitätsklinikum Gießen und Marburg - Gießen
state: Saarland
city: Halle
country: Germany
facility: Krankenhaus Martha-Maria Halle-Dölau
state: Sachsen-Anhalt
city: Grosshansdorf
country: Germany
facility: LungenClinic Grosshansdorf
state: Schleswig-Holstein
city: Berlin
country: Germany
facility: Charité - Universitätsmedizin Berlin
city: Piraeus
country: Greece
facility: Metropolitan Hospital
state: Athens
city: Athens
country: Greece
facility: Saint Savvas Anticancer - Oncological Hospital of Athens
state: Attica
city: Athens
country: Greece
facility: Henry Dunant Hospital Center
state: Attica
city: Athens
country: Greece
facility: General Hospital for Thoracic Diseases Sotiria
state: Attica
city: Néa Kifisiá
country: Greece
facility: Agii Anargiri Cancer Hospital
state: Attica
city: Thessaloniki
country: Greece
facility: Clinic Agios Loukas
state: Central Macedonia
city: Heraklion
country: Greece
facility: University General Hospital of Heraklion (PAGNI)
state: Crete
city: Thessaloniki
country: Greece
facility: General Hospital of Thessaloniki Papageorgiou
state: Macedoni
city: Patra
country: Greece
facility: University General Hospital of Patras
state: Peloponnese
city: Thessaloníki
country: Greece
facility: Theagenio Anti-Cancer Hospital of Thessaloniki
state: Thessaloniki
city: Larissa
country: Greece
facility: University General Hospital of Larissa
state: Thessaly
city: Gyöngyös
country: Hungary
facility: Mátrai Gyógyintézet
state: Heves
city: Budapest
country: Hungary
facility: Országos Korányi Pulmonológiai Intézet
city: Gyöngyös
country: Hungary
facility: Clinexpert Kft. telephelye, Bugát Pál Kórház - Phase I. Clinical Trial Site
city: Meldola
country: Italy
facility: Istituto Romagnolo per lo Studio dei Tumori "Dino Amadori" - IRST
state: Forlì-Cesena
city: San Filippo
country: Italy
facility: Presidio Ospedaliero di Lucca
state: Lucca
city: Rozzano
country: Italy
facility: Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) - Istituto Clinico Humanitas
state: Milan
city: Napoli
country: Italy
facility: Azienda Ospedaliera Universitaria - Università degli Studi della Campania Luigi Vanvitelli
state: Naples
city: Orbassano
country: Italy
facility: Azienda Ospedaliero - Universitaria San Luigi Gonzaga
state: Torino
city: Legnago
country: Italy
facility: Ospedale P. Pederzoli - Casa di Cura Privata S.p.A.
state: Verona
city: Genova
country: Italy
facility: Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) - Ospedale Policlinico San Martino
city: Lecce
country: Italy
facility: Ospedale Vito Fazzi Lecce
city: Milan
country: Italy
facility: Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) - Ospedale San Raffaele
city: Milan
country: Italy
facility: Fondazione IRCCS - Istituto Nazionale dei Tumori
city: Novara
country: Italy
facility: Azienda Ospedaliero-Universitaria Maggiore della Carità di Novara
city: Padova
country: Italy
facility: Ospedale Busonera - Istituto Oncologico Veneto (IOV) - Padua
city: Pisa
country: Italy
facility: Azienda Ospedaliero-Universitaria Pisana
city: Rimini
country: Italy
facility: Azienda Unità Sanitaria Locale della Romagna - Ospedale Infermi di Rimini
city: Roma
country: Italy
facility: IRCCS Istituto Nazionale Tumori Regina Elena
city: Rome
country: Italy
facility: Azienda Ospedaliera San Camillo Forlanini
city: Siena
country: Italy
facility: Azienda Ospedaliera Universitaria Senese - L'ospedale Santa Maria alle Scotte
city: Nijmegen
country: Netherlands
facility: Radboud Universitair Medisch Centrum
state: Gelderland
city: Rotterdam
country: Netherlands
facility: Erasmus Medisch Centrum
state: Zuid-Holland
city: Groningen
country: Netherlands
facility: Universitair Medisch Centrum Groningen
city: Bydgoszcz
country: Poland
facility: Centrum Onkologii Im. Prof. F. Łukaszczyka w Bydgoszczy
state: Kujawsko-pomorskie
city: Lublin
country: Poland
facility: Uniwersytecki Szpital Kliniczny Nr 4 w Lublinie
state: Lubelskie
city: Łódź
country: Poland
facility: Instytut Centrum Zdrowia Matki Polki
state: Lódzkie
city: Gdańsk
country: Poland
facility: Uniwersyteckie Centrum Kliniczne w Gdańsku
state: Pomorskie
city: Konin
country: Poland
facility: Przychodnia Lekarska KOMED Roman Karaszewski
state: Wielkopolskie
city: Poznan
country: Poland
facility: Wielkopolskie Centrum Pulmonologii i Torakochirurgii im. Eugenii i Janusza Zeylandów
state: Wielkopolskie
city: Coimbra
country: Portugal
facility: Unidade Local de Saúde de Coimbra
city: Lisboa
country: Portugal
facility: Hospital CUF Descobertas
city: Lisboa
country: Portugal
facility: Unidade Local de Saúde de Santa Maria, E. P. E. - Hospital Pulido Valente
city: Porto
country: Portugal
facility: Hospital CUF Porto
city: Vila Nova de Gaia
country: Portugal
facility: Unidade Local de Saúde de Gaia/Espinho, E. P. E
city: Cluj-Napoca
country: Romania
facility: Institutul Oncologic Prof. Dr. Ion Chiricuta
state: Cluj
city: Craiova
country: Romania
facility: Centrul de Oncologie Sf Nectarie
state: Dolj
city: Timisoara
country: Romania
facility: SC OncoMed SRL
state: Timis
city: Palma De Mallorca
country: Spain
facility: Hospital Son Llàtzer
state: Balearic Islands
city: Badalona
country: Spain
facility: Hospital Germans Trias i Pujol
state: Barcelona
city: L'Hospitalet De Llobregat
country: Spain
facility: Institut Català d'Oncologia - Hospital Duran i Reynals (ICO L'Hospitalet)
state: Barcelona
city: Barakaldo
country: Spain
facility: Biocruces Bizkaia Instituto de Investigación Sanitaria
state: Biscay
city: A Coruña
country: Spain
facility: Complejo Hospitalario Universitario A Coruña
state: La Coruña
city: Las Palmas De Gran Canaria
country: Spain
facility: Complejo Hospitalario Universitario Insular Materno Infantil
state: Las Palmas
city: Majadahonda
country: Spain
facility: Hospital Universitario Puerta de Hierro - Majadahonda
state: Madrid
city: Marbella
country: Spain
facility: HC Marbella
state: Malaga
city: Barcelona
country: Spain
facility: Clínica Mi Tres Torres
city: Barcelona
country: Spain
facility: Hospital Universitari Dexeus
city: Barcelona
country: Spain
facility: Hospital Universitari Vall d'Hebrón
city: Barcelona
country: Spain
facility: Hospital Clinic de Barcelona
city: Córdoba
country: Spain
facility: Hospital Universitario Reina Sofía
city: Girona
country: Spain
facility: Hospital Universitari de Girona Dr. Josep Trueta
city: Lugo
country: Spain
facility: Hospital Universitario Lucus Augusti
city: Madrid
country: Spain
facility: Hospital General Universitario Gregorio Marañón
city: Madrid
country: Spain
facility: Hospital Universitario Ramón y Cajal
city: Madrid
country: Spain
facility: Hospital Universitario La Paz
city: Málaga
country: Spain
facility: Hospital Regional Universitario de Málaga - Hospital General
city: Sevilla
country: Spain
facility: Hospital Universitario Virgen Macarena
city: Leicester
country: United Kingdom
facility: University Hospitals of Leicester NHS Trust
state: England
city: Manchester
country: United Kingdom
facility: The Christie NHS Foundation Trust
state: England
city: Sutton
country: United Kingdom
facility: The Royal Marsden NHS Foundation Trust
state: England
city: Wirral
country: United Kingdom
facility: The Clatterbridge Cancer Centre NHS Foundation Trust
state: England
city: Aberdeen
country: United Kingdom
facility: NHS Grampian
state: Scotland
Study officials:
References:
citation: Besse B, Felip E, Garcia Campelo R, Cobo M, Mascaux C, Madroszyk A, Cappuzzo F, Hilgers W, Romano G, Denis F, Viteri S, Debieuvre D, Galetta D, Baldini E, Razaq M, Robinet G, Maio M, Delmonte A, Roch B, Masson P, Schuette W, Zer A, Remon J, Costantini D, Vasseur B, Dziadziuszko R, Giaccone G; ATALANTE-1 study group. Randomized open-label controlled study of cancer vaccine OSE2101 versus chemotherapy in HLA-A2-positive patients with advanced non-small-cell lung cancer with resistance to immunotherapy: ATALANTE-1. Ann Oncol. 2023 Oct;34(10):920-933. doi: 10.1016/j.annonc.2023.07.006. Epub 2023 Sep 11.