Clinical trial NCT02205918: Brain-Behavior Interactions in Tic Suppression
Official title: Integrative Examination of Neurobehavioral Mechanisms in Tic Suppression
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Tourette's Syndrome
Chronic Motor Tic Disorder
Chronic Vocal Tic Disorder
Lead sponsor: University of Minnesota
Sponsor class: OTHER
First posted: 2014-08-01
Enrollment: 30
Sex: ALL
Minimum age (years): 12
Maximum age (years): 18
Standard ages: CHILD
ADULT
Accepts healthy volunteers: no
Observational model: CASE_ONLY
Time perspective: CROSS_SECTIONAL
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Community sample

Brief summary: The purpose of this study is to examine how the brain and environment interact to influence children's ability to suppress tics using a medical technology called Transcranial Magnetic Stimulation (TMS).

Detailed description: Objectives: This study will recruit youth with chronic tics. Chronic tics are the most common movement disorder in children. The goal of the study is to learn how the brain and environment influence children's ability to suppress tics. Specifically, we want to learn how tics are influenced by a certain part of the brain called the supplementary motor area (SMA). This part of the brain is thought to be more active in people with tics. This will be the first study to look at the relationship between SMA, tic suppression, and urges to tic.

Research Procedures: The study will take place over the course of three days within a week (about 5 hours total). The study will examine the relationship between the SMA and tic suppression using a non-invasive medical technology called Transcranial Magnetic Stimulation (TMS). Participants will have a diagnostic interview, MRI brain scan (used to find the location of the SMA), and TMS. Participants will be asked to try to suppress tics before and after TMS. The information that will be collected from participation includes information about tic symptoms, emotional and behavioral functioning, and brain activity (from MRI brain images and TMS results).

Eligibility criteria: Inclusion Criteria:

* Presence of motor and/or vocal tics for at least one year
* English fluency

Exclusion Criteria:

* Participants with medical conditions that are contraindicated for TMS (history of any known intracranial pathology, epilepsy or seizures, traumatic brain injury, brain tumor, stroke, implanted medical devices, current pregnancy or girls of childbearing age not using effective contraception, or any other serious medical conditions
* Left-handedness
* Previous diagnosis of psychosis, autism spectrum disorder, mental retardation, or cognitive disability
* Inability to undergo MRI
* Substance abuse or dependence within the past year
* History of ≥3 sessions of Habit Reversal Therapy or other treatment primarily comprised of tic suppression strategies
* Current suicidal intent
* Current neuroleptic medications, as these medications are known to lower seizure threshold

Primary outcomes:
measure: Tic frequency
timeFrame: Day 3
Secondary outcomes:
measure: Urge to tic
timeFrame: Day 3
Other outcomes:
Locations:
city: Minneapolis
country: United States
facility: University of Minnesota
state: Minnesota
Study officials:
affiliation: University of Minnesota
name: Christine Conelea, PhD
role: PRINCIPAL_INVESTIGATOR
References: