Clinical trial NCT03758937: Comparison of Volume Controlled Ventilation and Pressure Controlled Ventilation in Laparoscopic Bariatric Surgery
Official title: Comparison of Volume Controlled Ventilation and Pressure Controlled Ventilation in Terms of Respiratory Mechanics in Laparoscopic Bariatric Surgery
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Bariatric Surgery
Keywords: bariatric surgery
volume-controlled ventilation
pressure-controlled ventilation
Lead sponsor: Antalya Training and Research Hospital
Sponsor class: OTHER_GOV
First posted: 2018-11-29
Enrollment: 62
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: OTHER

Brief summary: The purpose of this study is to compare volume controlled-ventilation (VCV) and pressure-controlled ventilation (PCV) in terms of pulmonary gas exchange, respiratory mechanics and arterial blood gas values in patients undergoing laparoscopic bariatric surgery.

Detailed description: Today, morbid obesity has become a global problem. It is not clear which mechanical ventilation mode will be used in bariatric surgery, which is one of the treatment options of these patients. VCV is the most commonly used mode to ventilate anesthetized patients. However, especially in obese patients, high airway pressures and hypoxia may occur due to increased intrapulmonary shunts. Therefore, we aimed to investigate the potential of PCV strategy to improve pulmonary gas exchange, respiratory mechanics and arterial blood gas values according to VCV in patients undergoing bariatric surgery.

Eligibility criteria: Inclusion Criteria:

* 18 years or above,
* ASA II patients
* BMI \> 40 kg / m2
* No serious comorbidity.

Exclusion Criteria:

* Unstable patients during the operation
* The requirement for mechanical ventilation in the postoperative period.

Primary outcomes:
measure: Partial oxygen pressure
timeFrame: 5 minutes after induction
measure: Partial oxygen pressure
timeFrame: 30 minutes after pneumoperitoneum
measure: Partial oxygen pressure
timeFrame: through surgery completion, an average of 90 minutes
Secondary outcomes:
measure: Partial carbon dioxide pressure
timeFrame: 5 minutes after induction, 30 minutes after pneumoperitoneum, through surgery completion, an average of 90 minutes
measure: Partial carbon dioxide pressure - end-tidal carbon dioxide pressure
timeFrame: 5 minutes after induction, 30 minutes after pneumoperitoneum, through surgery completion, an average of 90 minutes
measure: Peak airway pressure
timeFrame: 5 minutes after induction, 30 minutes after pneumoperitoneum, through surgery completion, an average of 90 minutes
measure: Dynamic compliance
timeFrame: 5 minutes after induction, 30 minutes after pneumoperitoneum, through surgery completion, an average of 90 minutes
measure: Inspired oxygen pressure / Fractional oxygen ratio
timeFrame: 5 minutes after induction, 30 minutes after pneumoperitoneum, through surgery completion, an average of 90 minutes
measure: Alveolar-arterial oxygen gradient pressure
timeFrame: 5 minutes after induction, 30 minutes after pneumoperitoneum, through surgery completion, an average of 90 minutes
Other outcomes:
Locations:
city: Antalya
country: Turkey
facility: Antalya Traning and Research Hospital
Study officials:
affiliation: Antalya Training and Research Hospital
name: Erhan Ozyurt, MD
role: STUDY_DIRECTOR
References: