Clinical trial NCT00413699: Long-Term Effectiveness And Safety Of CP-690,550 For The Treatment Of Rheumatoid Arthritis
Official title: A Long-term, Open-label Follow-up Study Of Tofacitinib (Cp-690,550) For Treatment Of Rheumatoid Arthritis
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE3
Conditions: Arthritis, Rheumatoid
Keywords: long-term
open-label
safety
Lead sponsor: Pfizer
Sponsor class: INDUSTRY
First posted: 2006-12-20
Enrollment: 4488
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NON_RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The purpose of this study is to determine the long-term effectiveness and safety of CP-690,550 for the treatment of rheumatoid arthritis. Subjects are eligible for this study only after participating in another "qualifying" study of CP-690,550

A sub-study will be conducted within the A3921024 study, this study will evaluate the immune response to pneumococcal and influenza vaccines in patients receiving CP-690,550


Eligibility criteria: Inclusion Criteria:

* Subjects who have participated in a randomized "qualifying" study of CP-690,550 for the treatment of rheumatoid arthritis

Vaccine sub-study visit

* Subjects actively participating in Study A3921024 must have completed at least 3 months of continuous 10 mg BID CP-690,550 treatment in A3921024 as defined by \>80% compliance with prescribed dose consumption of CP-690,550 over the previous 3 months.

Exclusion Criteria:

* Serious medical conditions that would make treatment with CP-690,550 potentially unsafe

Vaccine sub-study visit

1. Any documented influenza or pneumococcal infection within the last 3 months prior to randomization in this study
2. Received any vaccine within 1 month prior to randomization in this study
3. Received an influenza vaccine within 6 months or a pneumococcal vaccine within 5 years of randomization in this study.

Primary outcomes:
measure: Initial Period: Primary Endpoints Were Standard Laboratory Safety Data (Chemistry, Hematology, Etc.) and Adverse Event (AE) Reports
timeFrame: Includes laboratory test abnormality data for all visits and adverse event data up to 999 days after last dose of study drug
measure: Extension Period: Number of Participants With Treatment Emergent Adverse Events (AEs), Serious Adverse Events (SAEs)
timeFrame: Baseline (Day 1 at Entry of Extension Period) up to 28 days after last study drug dose in Extension Period (13 Months)
measure: Extension Period: Number of Participants With Laboratory Test Abnormalities
timeFrame: Baseline (Day 1 at Entry of Extension Period) up to 28 days after last study drug dose in Extension Period (13 Months)
measure: Initial Period: The Long Term Safety and Tolerability of CP-690,550 5 Milligrams (mg) Twice Daily (BID) and 10 mg BID for the Treatment of Rheumatoid Arthritis
timeFrame: Includes AEs for every visit and up to 999 days after last dose of study drug
measure: Extension Period: Percentage of Participants With Adverse Events and Who Discontinued Treatment Due to Adverse Events to Assess Long-term Safety and Tolerability of Tofacitinib
timeFrame: Baseline (Day 1 at Entry of Extension Period) up to Month 6 of Extension Period; Month 6 of Extension Period to Month 12 of Extension Period
Secondary outcomes:
measure: Initial Period: Percentage of Patients With American College of Rheumatology (ACR) 20, 50, and 70 Responses
timeFrame: Every visit until study completion
measure: Extension Period: Percentage of Participants With American College of Rheumatology (ACR) 20, 50, and 70 Responses
timeFrame: Month 3, 6, 9 and 12 of Extension Period
measure: Initial Period: Area Under American College of Rheumatology (ACR) n Curve
timeFrame: Not applicable as no data were collected for this endpoint.
measure: Initial Period: Disease Activity Score (DAS)28 (C-reactive Protein [CRP]) and DAS28 (Erythrocyte Sedimentation Rate [ESR])
timeFrame: Every visit until study completion
measure: Extension Period: Change From Baseline in Disease Activity Score (DAS) 28-3 C-Reactive Protein (CRP)(DAS28-3 CRP) and DAS28-4 Erythrocyte Sedimentation Rate (ESR)(DAS28-4 ESR) at Month 3, 6, 9 and 12
timeFrame: Baseline (Month 0 at the entry of Initial period); Month 3, 6, 9 and 12 of Extension Period
measure: Initial Period: Number (%) of Participants With DAS28-4 (ESR) and DAS28-3 (CRP) <2.6 and ≤3.2
timeFrame: Every visit until study completion
measure: Extension Period: Percentage of Participants With DAS28-4 (ESR) and DAS28-3 (CRP) Less Than (<) 2.6 and Less Than or (<=) 3.2
timeFrame: Baseline (Day 1 at the entry of Extension period); Month 3, 6, 9 and 12 of Extension Period
measure: Initial Period: Health Assessment Questionnaire - Disability Index (HAQ-DI) Score
timeFrame: Every visit until study completion
measure: Extension Period: Change From Baseline in Health Assessment Questionnaire - Disability Index (HAQ-DI) Score at Month 3, 6, 9 and 12
timeFrame: Baseline (Month 0 at the entry of Initial Period); Month 3, 6, 9, and 12 of Extension Period
measure: Initial Period: Short-Form-36 Health Survey (SF-36) Score
timeFrame: Every visit until study completion
measure: Initial Period: FACIT Fatigue Scale, EuroQol EQ 5D, Work Limitations Questionnaire, and RA Healthcare Resource Utilization Questionnaire (RA-HCRU)
timeFrame: Every visit until study completion
measure: Initial Period: Preservation of Joint Structure in Participants Who Had Baseline Radiographs Obtained in Their Qualifying Index Study
timeFrame: Every 6 months until study completion
measure: Vaccine Sub-study. Percent Achieving a Satisfactory Humoral Response to the Pneumococcal Vaccine as Defined by ≥ 2-fold Increase in Antibody Concentrations
timeFrame: From vaccine sub-study visit 2 (baseline) to sub-study visit 4
measure: Vaccine Sub-study. Percent Achieving a Satisfactory Humoral Response to the Seasonal Influenza Vaccine as Defined by ≥ 4-fold Increase in Antibody Titers
timeFrame: From vaccine sub-study visit 2 (baseline) to sub-study visit 4
measure: Vaccine Sub-study. Percentage of Participants Achieving Protective Antibody Titers to the Seasonal Influenza Vaccine as Measured by a Hemagglutination Inhibition (HI) Assay Titer of ≥ 1:40 in ≥ 2 of 3 Influenza Antigens at Vaccine Sub-study Visit 3 and 4
timeFrame: From vaccine sub-study visit 2 (baseline) to sub-study visit 4
measure: Vaccine Sub-study. Percentage of Participants Who Respond to Each of the 12 Pneumococcal Antigens as Defined by ≥ 2-fold Increase in Antibody Concentrations From Vaccine Sub-study Visit 2 (Vaccination Baseline) Measured at Vaccine Sub-study Visit 4
timeFrame: From vaccine sub-study visit 2 (baseline) to sub-study visit 4
measure: Vaccine Sub-study. Percentage of Participants Who Respond to Each of the 3 Influenza Antigens as Defined by ≥ 4-fold Increase in Antibody Titers From Vaccine Sub-study Visit 2 (Vaccination Baseline) Measured at Vaccine Sub-study Visit 4
timeFrame: From vaccine sub-study visit 2 (baseline) to sub-study visit 4
measure: Vaccine Sub-study. Fold Increase of Anti-pneumococcal Antibody Levels to Each of the 12 Pneumococcal Antigens Above Vaccination Baseline Values (Vaccine Sub-study Visit 2) at Vaccine Sub-study Visit 4
timeFrame: From vaccine sub-study visit 2 (baseline) to sub-study visit 4
measure: Vaccine Sub-study. Fold Increase of Anti-influenza Antibody Levels to Each of the 3 Influenza Antigens Above Vaccination Baseline Values (Vaccine Sub-study Visit 2) at Vaccine Sub-study Visit 4
timeFrame: From vaccine sub-study visit 2 (baseline) to sub-study visit 4
measure: Vaccine Sub-study. Concentrations of Anti-pneumococcal Antibodies at Vaccine Sub-study Visit 3 and 4
timeFrame: From vaccine sub-study visit 2 (baseline) to sub-study visit 4
measure: Vaccine Sub-study. Titers of Anti-influenza Antibodies at Vaccine Sub-study Visit 3 and 4
timeFrame: From vaccine sub-study visit 2 (baseline) to sub-study visit 4
Other outcomes:
Locations:
city: Birmingham
country: United States
facility: University of Alabama at Birmingham
state: Alabama
city: Huntsville
country: United States
facility: Rheumatology Associates of North Alabama, PC
state: Alabama
city: Gilbert
country: United States
facility: Arthrocare, Arthritis Care & Research, PC
state: Arizona
city: Phoenix
country: United States
facility: Arizona Arthritis & Rheumatology Associates, P.C.
state: Arizona
city: Scottsdale
country: United States
facility: Radiant Research, Inc.
state: Arizona
city: Tucson
country: United States
facility: Catalina Pointe Clinical Research
state: Arizona
city: Hot Springs
country: United States
facility: CHI St. Vincent Medical Group Hot Springs
state: Arkansas
city: Jonesboro
country: United States
facility: NEA Baptist Clinic
state: Arkansas
city: Little Rock
country: United States
facility: Osborne Research Center, LLC
state: Arkansas
city: Little Rock
country: United States
facility: Little Rock Diagnostic Clinic, PA
state: Arkansas
city: Fair Oaks
country: United States
facility: Med Investigations, Inc.
state: California
city: Huntington Beach
country: United States
facility: Talbert Medical Group
state: California
city: La Jolla
country: United States
facility: University of California San Diego Center for Innovative Therapy
state: California
city: Los Angeles
country: United States
facility: Keck Medicine of USC
state: California
city: Los Angeles
country: United States
facility: University of Southern California (USC) Norris Comprehensive Cancer Center-
state: California
city: Los Angeles
country: United States
facility: University of Southern California (USC) Norris Comprehensive Cancer Center
state: California
city: Los Angeles
country: United States
facility: Ronald Reagan UCLA Medical Center, Drug Information Center
state: California
city: Los Angeles
country: United States
facility: University of California Los Angeles
state: California
city: Palo Alto
country: United States
facility: Stanford University School of Medicine
state: California
city: Roseville
country: United States
facility: Office of Anupama Bhat, MD
state: California
city: San Diego
country: United States
facility: San Diego Arthritis Medical Clinic
state: California
city: Santa Maria
country: United States
facility: Pacific Arthritis Center Medical Group
state: California
city: Stanford
country: United States
facility: Stanford Health Services - Medical Specialty Clinics
state: California
city: Upland
country: United States
facility: Inland Rheumatology Clinical Trials, Inc.
state: California
city: Boulder
country: United States
facility: Boulder Medical Center, PC
state: Colorado
city: Colorado Springs
country: United States
facility: Arthritis Associates and Osteoporosis Center of Colorado Springs
state: Colorado
city: Farmington
country: United States
facility: University of Connecticut Health Center
state: Connecticut
city: Hamden
country: United States
facility: Arthritis & Osteoporosis Center, PC
state: Connecticut
city: Trumbull
country: United States
facility: New England Research Associates, LLC
state: Connecticut
city: Newark
country: United States
facility: Delaware Arthritis and Osteoporosis Center
state: Delaware
city: Aventura
country: United States
facility: Arthritis and Rheumatic Disease Specialties
state: Florida
city: Daytona Beach
country: United States
facility: Allergy, Asthma, Arthritis, & Lung
state: Florida
city: DeBary
country: United States
facility: Physicians Research Alliance LLC
state: Florida
city: Gainesville
country: United States
facility: Southeastern Arthritis Center
state: Florida
city: Gainesville
country: United States
facility: Southeastern Imaging and Diagnostics
state: Florida
city: Gainesville
country: United States
facility: Southeastern Integrated Medical PL d/b/a Florida Medical Research Institute
state: Florida
city: Gainesville
country: United States
facility: Southeastern Integrated Medical, PL, d/b/a Florida Medical Research Institute
state: Florida
city: Jacksonville
country: United States
facility: Jacksonville Center for Clinical Research
state: Florida
city: Lake Mary
country: United States
facility: Florida Arthritis Center, P.L.
state: Florida
city: Largo
country: United States
facility: BayCare Outpatient Imaging at Bardmoor
state: Florida
city: Miami
country: United States
facility: Center for Arthritis and Rheumatic Diseases
state: Florida
city: Naples
country: United States
facility: Jeffrey Alper MD Research
state: Florida
city: New Port Richey
country: United States
facility: Suncoast Clinical Research, Inc.
state: Florida
city: Ocala
country: United States
facility: Ocala Rheumatology Research Center
state: Florida
city: Orlando
country: United States
facility: Dr. Jeffrey E. Poiley, MD , Office of
state: Florida
city: Ormond Beach
country: United States
facility: Millennium Research
state: Florida
city: Pinellas Park
country: United States
facility: DMI Research, Inc.
state: Florida
city: Port Richey
country: United States
facility: Florida Arthritis & Osteoporosis Center
state: Florida
city: Port Richey
country: United States
facility: Gulf Coast Medical Center
state: Florida
city: Saint Petersburg
country: United States
facility: Suncoast Medical Clinic
state: Florida
city: South Miami
country: United States
facility: Arthritis & Rheumatic Care Center
state: Florida
city: South Miami
country: United States
facility: Miami Research Associates
state: Florida
city: Tamarac
country: United States
facility: West Broward Rheumatology Associates, Inc.
state: Florida
city: Tampa
country: United States
facility: BayCare Medical Group, Inc
state: Florida
city: Venice
country: United States
facility: Lovelace Scientific Resources
state: Florida
city: Venice
country: United States
facility: Venice Arthritis Center
state: Florida
city: Zephyrhills
country: United States
facility: Florida Medical Clinic, P.A.
state: Florida
city: Atlanta
country: United States
facility: Arthritis and Rheumatology of Georgia P.C.
state: Georgia
city: Decatur
country: United States
facility: Jeffrey D. Lieberman, MD, PC
state: Georgia
city: Marietta
country: United States
facility: Marietta Rheumatology Associates
state: Georgia
city: Boise
country: United States
facility: St. Luke's Clinic - Rheumatology
state: Idaho
city: Boise
country: United States
facility: St. Luke's Clinic
state: Idaho
city: Boise
country: United States
facility: St. Luke's Intermountain Research Center
state: Idaho
city: Idaho Falls
country: United States
facility: Institute of Arthritis Research
state: Idaho
city: Meridian
country: United States
facility: St. Luke's Clinic - Rhematology
state: Idaho
city: Maywood
country: United States
facility: Loyola University Medical Center
state: Illinois
city: Morton Grove
country: United States
facility: Illinois Bone and Joint Institute, LLC
state: Illinois
city: Rockford
country: United States
facility: Rockford Health Physicians
state: Illinois
city: Rockford
country: United States
facility: Rockford Orthopedic Associates
state: Illinois
city: Springfield
country: United States
facility: Springfield Clinic
state: Illinois
city: Springfield
country: United States
facility: Springfield Clinic - Clinical Research
state: Illinois
city: Vernon Hills
country: United States
facility: Deerbrook Medical Associates
state: Illinois
city: Indianapolis
country: United States
facility: Diagnostic Rheumatology And Research PC
state: Indiana
city: Cedar Rapids
country: United States
facility: Physician's Clinic of Iowa, P.C.
state: Iowa
city: Dubuque
country: United States
facility: Medical Associates Clinic, PC
state: Iowa
city: Overland Park
country: United States
facility: Kansas City Internal Medicine
state: Kansas
city: Wichita
country: United States
facility: Professional Research Network of Kansas, LLC
state: Kansas
city: Wichita
country: United States
facility: Via Christi Clinic, P.A.
state: Kansas
city: Lexington
country: United States
facility: Bluegrass Community Research, Inc.
state: Kentucky
city: Baton Rouge
country: United States
facility: Ochsner Clinic Foundation - Baton Rouge
state: Louisiana
city: New Orleans
country: United States
facility: Louisiana State University Health Sciences Center
state: Louisiana
city: Portland
country: United States
facility: Rheumatology Associates
state: Maine
city: Cumberland
country: United States
facility: Klein and Associates, MD, PA
state: Maryland
city: Frederick
country: United States
facility: The Arthritis Treatment Center
state: Maryland
city: Wheaton
country: United States
facility: The Center for Rheumatology and Bone Research
state: Maryland
city: Hyannis
country: United States
facility: Clinical Research Center of Cape Cod, Inc.
state: Massachusetts
city: Worcester
country: United States
facility: Reliant Medical Group, Inc.
state: Massachusetts
city: Worcester
country: United States
facility: Reliant Medical Group, Inc. at Worcester Medical Center
state: Massachusetts
city: Battle Creek
country: United States
facility: Bronson Internal Medicine and Rheumatology
state: Michigan
city: Bingham Farms
country: United States
facility: QUEST Research Institiute
state: Michigan
city: Kalamazoo
country: United States
facility: Borgess Research Institute
state: Michigan
city: Southfield
country: United States
facility: Farmbrook Radiology Associates
state: Michigan
city: Edina
country: United States
facility: Arthritis and Rheumatology Consultants, P.A.
state: Minnesota
city: Tupelo
country: United States
facility: North Mississippi Medical Clinics, Inc.
state: Mississippi
city: Columbia
country: United States
facility: University Physicians - Woodrail Clinic
state: Missouri
city: Columbia
country: United States
facility: University Of Missouri-Columbia
state: Missouri
city: Lincoln
country: United States
facility: Physician Research Collaboration, LLC
state: Nebraska
city: Massachusetts
country: United States
facility: Clinical Pharmacology Study Group
state: Nebraska
city: Omaha
country: United States
facility: Westroads Clinical Research, Inc.
state: Nebraska
city: Omaha
country: United States
facility: Heartland Clinic Research, Inc.
state: Nebraska
city: Lebanon
country: United States
facility: Dartmouth-Hitchcock Medical Center
state: New Hampshire
city: Teaneck
country: United States
facility: Rheumatology Associates of North Jersey
state: New Jersey
city: Voorhees
country: United States
facility: Arthritis, Rheumatic & Back Disease Associates
state: New Jersey
city: Albany
country: United States
facility: The Center for Rheumatology, LLP
state: New York
city: Binghamton
country: United States
facility: Regional Rheumatology Associates
state: New York
city: Olean
country: United States
facility: Southern Tier Arthritis and Rheumatism
state: New York
city: Orchard Park
country: United States
facility: Buffalo Rheumatology and Medicine, PLLC
state: New York
city: Rochester
country: United States
facility: AAIR Research Center
state: New York
city: Asheville
country: United States
facility: Asheville Rheumatology & Osteoporosis Research Associates, P.A.
state: North Carolina
city: Asheville
country: United States
facility: Asheville Rheumatology & Osteoporosis Research Associates, PA
state: North Carolina
city: Charlotte
country: United States
facility: DJL Clinical Research, PLLC
state: North Carolina
city: Hickory
country: United States
facility: PMG Research Hickory, LLC
state: North Carolina
city: Hickory
country: United States
facility: PMG Research of Hickory
state: North Carolina
city: Rocky Mount
country: United States
facility: Boice-Willis Clinic
state: North Carolina
city: Minot
country: United States
facility: Trinity Health Center - Medical Arts
state: North Dakota
city: Cincinnati
country: United States
facility: Cincinnati Rheumatic Disease Study Group, Inc.
state: Ohio
city: Dayton
country: United States
facility: STAT Research, Inc.
state: Ohio
city: Mayfield
country: United States
facility: Office of David R. Mandel, MD, Inc.
state: Ohio
city: Oklahoma City
country: United States
facility: Oklahoma Medical Research Foundation (OMRF)
state: Oklahoma
city: Oklahoma City
country: United States
facility: Lynn Health Science Institute
state: Oklahoma
city: Bethlehem
country: United States
facility: East Penn Rheumatology Associates, PC
state: Pennsylvania
city: Duncansville
country: United States
facility: Altoona Center for Clinical Research
state: Pennsylvania
city: Willow Grove
country: United States
facility: Rheumatic Disease Associates, Ltd.
state: Pennsylvania
city: Wyomissing
country: United States
facility: Clinical Research Center of Reading LLP
state: Pennsylvania
city: Greenville
country: United States
facility: Piedmont Arthritis Clinic, PA
state: South Carolina
city: Hixson
country: United States
facility: Arthritis Associates, PLLC
state: Tennessee
city: Jackson
country: United States
facility: Arthritis Clinic
state: Tennessee
city: Jackson
country: United States
facility: West Tennessee Research Institute
state: Tennessee
city: Knoxville
country: United States
facility: Rheumatology Consultants, PLLC
state: Tennessee
city: Nashville
country: United States
facility: Vanderbilt University Medical Center
state: Tennessee
city: Allen
country: United States
facility: Office of John P. Lavery, MD, PA
state: Texas
city: Austin
country: United States
facility: Austin Rheumatology Research, PA
state: Texas
city: Dallas
country: United States
facility: Arthritis Care and Diagnostic Center, P.A.
state: Texas
city: Dallas
country: United States
facility: Baylor Research Institute
state: Texas
city: Dallas
country: United States
facility: Metroplex Clinical Research Center
state: Texas
city: Fort Worth
country: United States
facility: University of North Texas Health Science Center at Fort Worth
state: Texas
city: Houston
country: United States
facility: Accurate Clinical Research, Inc.
state: Texas
city: Houston
country: United States
facility: Houston Institute for Clinical Research
state: Texas
city: Lubbock
country: United States
facility: Arthritis and Osteoporosis Associates, LLP
state: Texas
city: Mesquite
country: United States
facility: Southwest Rheumatology Research, LLC
state: Texas
city: Seattle
country: United States
facility: Virginia Mason Medical Center
state: Washington
city: Seattle
country: United States
facility: Seattle Rheumatology Associates
state: Washington
city: Seattle
country: United States
facility: The Seattle Arthritis Clinic
state: Washington
city: Tacoma
country: United States
facility: Tacoma Center of Arthritis Research, PS
state: Washington
city: Vancouver
country: United States
facility: The Vancouver Clinic, Inc. PS
state: Washington
city: Clarksburg
country: United States
facility: Mountain State Clinical Research
state: West Virginia
city: Onalaska
country: United States
facility: Gundersen Clinic, Ltd
state: Wisconsin
city: Buenos Aires
country: Argentina
facility: OMI- Organizacion Medica de Investigacion
state: Caba
city: Buenos Aires
country: Argentina
facility: Centro de Investigaciones Reumatologicas y Osteologicas -CIRO
state: Caba
city: Buenos Aires
country: Argentina
facility: Hospital Sirio Libanes
city: Buenos Aires
country: Argentina
facility: OMI - Organización Médica de Investigación
city: Buenos Aires
country: Argentina
facility: Saint Dennis Medical Group S.A.
city: Buenos Aires
country: Argentina
facility: Hospital Sirio Libanes
city: Buenos Aires
country: Argentina
facility: Consultorios Reumatologicos Pampa
city: Kogarah
country: Australia
facility: Optimus Clinical Research Pty. Ltd.
state: New South Wales
city: Cairns
country: Australia
facility: Rheumatology Research
state: Queensland
city: Maroochydore
country: Australia
facility: Rheumatology Research Unit Sunshine Coast
state: Queensland
city: Woodville
country: Australia
facility: Queen Elizabeth Hospital, Department of Rheumatology
state: South Australia
city: Malvern East
country: Australia
facility: Emeritus Research
state: Victoria
city: Perth
country: Australia
facility: Goatcher Clinical Research Unit
state: Western Australia
city: St Leonards
country: Australia
facility: Royal North Shore Hospital
city: Wien
country: Austria
facility: Medizinische Universitaet Wien / AKH
city: Wien
country: Austria
facility: Rheuma-Ordination Favoriten
city: Wien
country: Austria
facility: Sozialmedizinisches Zentrum Sued - Kaiser Franz Josef Spital
city: Gent
country: Belgium
facility: Universitair Ziekenhuis Gent - Reumatologie
state: Oost-vlaanderen
city: Kortrijk
country: Belgium
facility: AZ Groeninge
city: Liège
country: Belgium
facility: Centre Hospitalier Universitaire de Liège
city: Sarajevo
country: Bosnia and Herzegovina
facility: University Clinical Center Sarajevo
city: Goiania
country: Brazil
facility: CIP - Centro Internacional de Pesquisa
state: GO
city: Curitiba
country: Brazil
facility: Centro de Estudos em Terapias Inovadoras
state: Paraná
city: Curitiba
country: Brazil
facility: Centro de Estudos em Terapias Inovadoras
state: PR
city: Rio de Janeiro
country: Brazil
facility: CCBR Brasil Centro de Pesquisas e Analises Clinicas Ltda
state: RJ
city: Porto Alegre
country: Brazil
facility: Hospital de Clinicas de Porto Alegre
state: RS
city: Porto Alegre
country: Brazil
facility: Hospital Sao Lucas da PUCRS
state: RS
city: Sao Paulo
country: Brazil
facility: Hospital Alemao Oswaldo Cruz
state: SP
city: Sao Paulo
country: Brazil
facility: Hospital das Clinicas da Faculdade de Medicina da Universidade de Sao Paulo (HC-FMUSP)
state: SP
city: Sao Paulo
country: Brazil
facility: IMA Brasil -Instituto de Pesquisa Clinica e Medicina Avancada
state: SP
city: Sao Paulo
country: Brazil
facility: CEPIC - Centro Paulista de Investigacao Clinica e Servicos Medicos Ltda
city: Pleven
country: Bulgaria
facility: Revmatologichen kabinet, DKTs Sveti Pantaleimon OOD
city: Plovdiv
country: Bulgaria
facility: Revmatologichno Otdelenie, MBAL - Plovdiv
city: Plovdiv
country: Bulgaria
facility: UMBAL Kaspela Plovdiv
city: Sevlievo
country: Bulgaria
facility: MBAL Akta Medika OOD
city: Sofia
country: Bulgaria
facility: Clinic of Cardiology and Rheumatology Military Medical Academy
city: Sofia
country: Bulgaria
facility: Clinic of Rheumatology Multiprofile Hospital for Active treatment Sveti Ivan Rilski
city: Sofia
country: Bulgaria
facility: MBAL Sveti Ivan Rilski Sofia
city: Sofia
country: Bulgaria
facility: DKTs "Sveta Anna" Sofia, Konsultativen kabinet po Revmatologia
city: Sofia
country: Bulgaria
facility: DKTs "Sveta Anna", Sofia / Diagnostic Consultative Center "Sveta Anna"
city: Veliko Tarnovo
country: Bulgaria
facility: MOBAL "D-r Stefan Cherkezov" AD,
city: Edmonton
country: Canada
facility: Rheumatology Research Associates Ltd.
state: Alberta
city: Vancouver
country: Canada
facility: Dr. Alice Klinkhoff, Inc.
state: British Columbia
city: Victoria
country: Canada
facility: Percuro Clinical Research Limited
state: British Columbia
city: Winnipeg
country: Canada
facility: Manitoba Clinic
state: Manitoba
city: St. John's
country: Canada
facility: Nexus Clinical Research
state: Newfoundland and Labrador
city: Hamilton
country: Canada
facility: Dr. William G. Bensen Medicine Professional Corporation
state: Ontario
city: Hamilton
country: Canada
facility: Office of Dr. Fernando Bianchi
state: Ontario
city: Hamilton
country: Canada
facility: Cividino Medicine Professional Corporation
state: Ontario
city: Kitchener
country: Canada
facility: KW Musculoskeletal Research Inc.
state: Ontario
city: London
country: Canada
facility: St Joseph's Health Centre
state: Ontario
city: Missisauga
country: Canada
facility: Credit Valley Rheumatology
state: Ontario
city: Newmarket
country: Canada
facility: The Arthritis Program Research Group Inc.
state: Ontario
city: Oakville
country: Canada
facility: Rheumatology and Osteoporosis Clinic
state: Ontario
city: Ottawa
country: Canada
facility: Rheumatology Research Associates
state: Ontario
city: St. Catharines
country: Canada
facility: Niagara Peninsula Arthritis Centre
state: Ontario
city: Windsor
country: Canada
facility: Clinical Research and Arthritis Centre
state: Ontario
city: Montreal
country: Canada
facility: Institut de Rhumatologie de Montreal
state: Quebec
city: Pointe Claire
country: Canada
facility: West Island Rheumatology Research Associates
state: Quebec
city: Trois-Rivieres
country: Canada
facility: Centre de Recherche Musculo-Squelettique
state: Quebec
city: Saskatoon
country: Canada
facility: Arthritis Research Center, Royal University Hospital
state: Saskatchewan
city: Quebec
country: Canada
facility: Groupe De Recherche En Rhumatologie Et Maladies Osseuses Inc.
city: Quebec
country: Canada
facility: Centre de Recherche Saint-Louis
city: Temuco
country: Chile
facility: Consulta Privada Dra. Lucia Ponce
state: IX Region
city: Santiago
country: Chile
facility: Centro de Diagnostico y Tratamiento Hospital San Borja Arriaran
state: Region Metropolitana
city: Valdivia
country: Chile
facility: Hospital Base Valdivia, Policlinico de Reumatologia
state: Region XIV
city: Santiago
country: Chile
facility: Centro de Estudios Reumatologicos
state: RM
city: Santiago
country: Chile
facility: Consulta Privada Dra. Marta Aliste
state: RM
city: Providencia
country: Chile
facility: Clinica Santa Maria, Seccion Reumatologia
state: Santiago, RM
city: Rancagua
country: Chile
facility: Hospital Regional de Rancagua
city: Santiago
country: Chile
facility: Clinica Santa Maria
city: Vina Del Mar, V Region
country: Chile
facility: Estudios Clinicos V Region
city: Beijing
country: China
facility: Beijing Chaoyang Hospital, Capital University of Medical Science
state: Beijing
city: Guangzhou
country: China
facility: The Second Affiliated Hospital of Guangzhou Medical University
state: Guangdong
city: Guangzhou
country: China
facility: The Third Affiliated Hospital of Sun Yat-Sen University
state: Guangdong
city: Wuhan
country: China
facility: Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology
state: Hubei
city: Changsha
country: China
facility: Xiangya Hospital of Centre-south University
state: Hunan
city: Xi'an
country: China
facility: Xijing Hospital, The Fourth Military Medical University
state: Shaanxi
city: Jinan
country: China
facility: QiLu Hospital of Shandong University
state: Shandong
city: Qingdao
country: China
facility: Qingdao Municipal Hospital
state: Shandong
city: Shanghai
country: China
facility: Shanghai Changzheng Hospital
state: Shanghai
city: Beijing
country: China
facility: Peking University People's Hospital/Rheumatology and Immunology Department
city: Beijing
country: China
facility: PLA General Hospital
city: Chengdu
country: China
facility: Si Chuan Huaxi Hospital
city: Hangzhou
country: China
facility: The Second Affiliated Hospital of Zhejiang University School of Medicine
city: Hefei
country: China
facility: Anhui Province Hospital
city: Hefei
country: China
facility: An Hui Medical University 1st Hospital
city: Nanjing
country: China
facility: Jiangsu Province Hospital
city: Shanghai
country: China
facility: Rheumatology and Immunology Dept., Renji Hospital Shanghai Jiao Tong University School of Medicine
city: Shanghai
country: China
facility: Shanghai Changhai Hospital
city: Suzhou
country: China
facility: The First Affiliated Hospital of Soochow University
city: Tianjin
country: China
facility: "Department of Infectious Diseases & Immunology
city: Barranquilla
country: Colombia
facility: Centro de Reumatologia y Ortopedia S.A.S.
state: Atlantico
city: Bogota D.C.
country: Colombia
facility: Riesgo de Fractura S.A.
state: Cundinamarca
city: Bogota, D.C.
country: Colombia
facility: Centro de Investigacion en Reumatologia y Especialidades Medicas S.A.S CIREEM S.A.S
state: Cundinamarca
city: Bucaramanga
country: Colombia
facility: Servimed S.A.S.
state: Santander
city: Cartago
country: Costa Rica
facility: Centro de Reumatologia y Osteoporosis, Cartago
city: San Jose
country: Costa Rica
facility: Hospital Cima San Jose
city: San Jose
country: Costa Rica
facility: Hospital Cima San Jose
city: San Jose
country: Costa Rica
facility: Oficina Privada Del Colegio deMedicos
city: Osijek
country: Croatia
facility: University Hospital Center Osijek
city: Split
country: Croatia
facility: University Hospital Split, Department for Internal Medicine, Division of Clinical Rheumatology
city: Zagreb
country: Croatia
facility: Clinical Hospital "Sveti Duh"
city: Zagreb
country: Croatia
facility: University Hospital Center "Zagreb"
city: Zagreb
country: Croatia
facility: University Hospital Center Zagreb
city: Brno
country: Czechia
facility: X-MEDICA s.r.o.
city: Brno
country: Czechia
facility: Revmacentrum MUDr. Mostera, s.r.o.
city: Brno
country: Czechia
facility: Fakultni Nemocnice Brno, Interni hematoonkologicka klinika
city: Brno
country: Czechia
facility: Fakultni nemocnice u sv. Anny v Brne
city: Ceska Lipa
country: Czechia
facility: HESTE s.r.o. Revmatologie
city: Ceske Budejovice
country: Czechia
facility: MEDIPONT Plus sro
city: Hlucin
country: Czechia
facility: L.K.N. Arthrocentrum, s.r.o.
city: Hostivice
country: Czechia
facility: ARTMEDI UPD s r.o
city: Hradec Kralove
country: Czechia
facility: Fakultni nemocnice Hradec Kralove
city: Ostrava
country: Czechia
facility: Revmatologicka ambulance
city: Pardubice
country: Czechia
facility: ARTHROMED, s. r. o. Revmatologicka ambulance
city: Praha 11 - Chodov
country: Czechia
facility: Affidea Praha, s.r.o.
city: Praha 2
country: Czechia
facility: Revmatologicky ustav
city: Praha 4
country: Czechia
facility: Revmatologicka ambulance
city: Praha 4
country: Czechia
facility: Fakultni Thomayerova nemocnice s poliklinikou
city: Praha 4
country: Czechia
facility: Nuselska poliklinika RTG
city: Praha 4
country: Czechia
facility: Revmatologicka ambulance
city: Zlin
country: Czechia
facility: Nemocnice Atlas, a.s.
city: Zlin
country: Czechia
facility: PV-Medical s.r.o.
city: Frederiksberg
country: Denmark
facility: Frederiksberg Hospital
city: Santo Domingo
country: Dominican Republic
facility: Hospital Central de las Fuerzas Armadas
city: Helsinki
country: Finland
facility: Helsingin Reumakeskus Oy
city: Hyvinkaa
country: Finland
facility: Kiljavan Laaketutkimus Oy
city: Tampere
country: Finland
facility: TAYS/Reumakeskus/Finn-Medi 1
city: Amiens
country: France
facility: Hopital Nord
city: Amiens
country: France
facility: Hôpital Nord
city: Orleans
country: France
facility: *CHR Hopital Porte Madeleine IPROS
city: Orleans
country: France
facility: CHR ORLEANS - Service IPROS
city: Paris
country: France
facility: Hôpital Saint-Antoine
city: Paris
country: France
facility: Hopital Cochin
city: Aachen
country: Germany
facility: Privat-Praxis
city: Berlin
country: Germany
facility: Charite Campus Mitte, Medizinische Klinik mit Schwerpunkt Rheumatologie und Klinische Immunologie
city: Berlin
country: Germany
facility: Schlosspark-Klinik Innere Medizin II, Rheumatologie
city: Berlin
country: Germany
facility: Ambulantes Rheumazentrum Dr Soerensen
city: Dresden
country: Germany
facility: Krankenhaus Friedrichstadt, I. Medizinische Klinik
city: Erlangen
country: Germany
facility: Studienambulanz Universitaetsklinikum Erlangen Medizinische Klinik 3
city: Frankfurt am Main
country: Germany
facility: J.W.-Goethe-Universitaetsklinik, Medizinische Klinik II, Abteilung fuer Rheumatologie
city: Halle
country: Germany
facility: Schwerpunktpraxis Rheumatologie
city: Hamburg
country: Germany
facility: Schoen Klinik Hamburg-Eilbek
city: Herne
country: Germany
facility: Rheumazentrum Ruhrgebiet
city: Koeln
country: Germany
facility: Universitaetsklinikum Koeln Klinik I fuer Innere Medizin, Haus 16, 1. OG, Raum 1.008
city: Leipzig
country: Germany
facility: Universitaetsklinik Leipzig, Klinik fur Gastroenterologie und Rheumatologie, Sektion Rheumatologie
city: Leipzig
country: Germany
facility: Universitaetsklinikum Leipzig
city: Muenchen
country: Germany
facility: Klinikum der Universitaet Muenchen, Campus Innenstadt, Rheuma-Einheit
city: Nuernberg
country: Germany
facility: Arztpraxis, Internist - Rheumatologie
city: Ratingen
country: Germany
facility: Rheumaforschung- Studienambulanz
city: Rheine
country: Germany
facility: Schwerpunktpraxis fuer Rheumatologie
city: Wuerzburg
country: Germany
facility: Universitaetsklinikum Wuerzburg
city: Thessaloniki
country: Greece
facility: General Hospital Euromedica "KYANOUS STAVROS"
city: Thessaloniki
country: Greece
facility: 424 General Army Hospital
city: Balatonfured
country: Hungary
facility: Drug Research Center Kft
city: Budapest
country: Hungary
facility: Orszagos Reumatologiai Es Fizioterapias Intezet
city: Budapest
country: Hungary
facility: Revita Reumatologiai Rendelo
city: Budapest
country: Hungary
facility: Synexus Magyarorszag Kft.
city: Szolnok
country: Hungary
facility: MAV Korhaz es Rendelointezet, Reumatologiai szakrendeles
city: Hyderabad
country: India
facility: Mahavir Hospital & Research Center
state: Andhra Pradesh
city: Ahmedabad
country: India
facility: Rheumatic Diseases Clinic
state: Gujarat
city: Ahmedabad
country: India
facility: Shalby Hospitals
state: Gujarat
city: Bangalore
country: India
facility: Chanre Rheumatology and Immunology Center and Research
state: Karnataka
city: Bangalore
country: India
facility: St. John's Medical College and Hospital.
state: Karnataka
city: Bangalore
country: India
facility: Shirdi Sai Hospital
state: Karnataka
city: Bangalore
country: India
facility: Chanre Rheumatology & Immunology Center & Research
state: Karnataka
city: Pune
country: India
facility: Arthritis Research and Care Foundation Centre for Rheumatic Diseases
state: Maharashtra
city: Pune
country: India
facility: Jehangir Clinical Development Centre Pvt. Ltd.
state: Maharashtra
city: Secunderabad
country: India
facility: Krishna Institute of Medical Sciences Ltd
state: Telangana
city: Elm Park
country: Ireland
facility: St. Vincent's University Hospital
state: Dublin
city: Firenze
country: Italy
facility: A.O.U. Careggi - SOD Medicina Interna 1 e Reumatologia
state: FI
city: Genova
country: Italy
facility: U.O. Clinica Reumatologica
city: Jung-gu
country: Korea, Republic of
facility: Inha University Hospital
state: Incheon
city: Daejeon
country: Korea, Republic of
facility: Eulji University Hospital
state: Republic OF Korea
city: Busan
country: Korea, Republic of
facility: Dong-A University Hospital
city: Daegu
country: Korea, Republic of
facility: Daegu Catholic University Medical Center
city: Gwangju
country: Korea, Republic of
facility: Chonnam National University Hospital
city: Seoul,
country: Korea, Republic of
facility: Gangnam Severance Hospital
city: Seoul
country: Korea, Republic of
facility: Seoul National University Hospital
city: Seoul
country: Korea, Republic of
facility: Yonsei University Health System
city: Seoul
country: Korea, Republic of
facility: Hanyang University Hospital
city: Seoul
country: Korea, Republic of
facility: Konkuk University Medical Center
city: Seoul
country: Korea, Republic of
facility: Asan Medical Center-University of Ulsan College of Medicine
city: Seoul
country: Korea, Republic of
facility: Asan Medical Center
city: Seoul
country: Korea, Republic of
facility: Gangnam Severance Hospital-Yonsei University Health System
city: Seoul
country: Korea, Republic of
facility: Seoul St. Mary's Hospital-The Catholic University of Korea
city: Seremban
country: Malaysia
facility: Hospital Tuanku Ja'afar
state: Negeri Sembilan
city: Kota Kinabalu
country: Malaysia
facility: Queen Elizabeth Hospital
state: Sabah
city: Kuching
country: Malaysia
facility: Sarawak General Hospital
state: Sarawak
city: Batu Caves
country: Malaysia
facility: Hospital Selayang
state: Selangor
city: Petaling Jaya
country: Malaysia
facility: Sunway Medical Centre
state: Selangor
city: Subang Jaya
country: Malaysia
facility: Subang Jaya Medical Centre
state: Selangor
city: Putrajaya
country: Malaysia
facility: Hospital Putrajaya, Dept. of Medicine
state: Wilayah Persekutuan
city: Tijuana
country: Mexico
facility: Centro de Investigacion del Noroeste
state: BAJA California Norte
city: Torreon
country: Mexico
facility: Unidad de Enfermedades Reumaticas y Cronico Degenerativas SC
state: Coahuila
city: Mexico
country: Mexico
facility: Hospital Angeles del Pedregal
state: DF
city: Metepec
country: Mexico
facility: Centro Medico Toluca
state: Estado DE Mexico
city: Guadalajara
country: Mexico
facility: Centro Integral en Reumatologia, SA de CV
state: Jalisco
city: Guadalajara
country: Mexico
facility: Unidad de Investigacion en Enfermedades Cronico Degenerativas
state: Jalisco
city: Coyoacan
country: Mexico
facility: Centro de Investigacion Clinica Especializada, SC
state: Mexico D.F.
city: Morelia
country: Mexico
facility: Centro de Investigacion Clinica de Morelia
state: Michoacan
city: Morelia
country: Mexico
facility: Clinica de Enfermedades Cronicas y Procedimientos Especiales SC
state: Michoacan
city: Cuernavaca
country: Mexico
facility: Fundacion El Hospitalito
state: Morelos
city: Monterrey
country: Mexico
facility: Hospital Universitario Doctor Jose Eleuterio Gonzalez
state: Nuevo LEON
city: Merida
country: Mexico
facility: Unidad Reumatologica Las Americas SCP
state: Yucatan
city: Chihuahua
country: Mexico
facility: Investigacion y Biomedica de Chihuahua, SC
city: Mexico City
country: Mexico
facility: Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran
city: Mexico, D.F.
country: Mexico
facility: Hospital Angeles Mocel
city: Queretaro
country: Mexico
facility: Centro Reumatologico Queretaro
city: San Luis Potosi
country: Mexico
facility: Centro de Alta Especialidad en Reumatologia e Investigacion del Potosi, S.C.
city: San Luis Potosi
country: Mexico
facility: Hospital Central Dr Ignacio Morones Prieto Unidad Regional de Reumatologia y Osteoporosis
city: Christchurch
country: New Zealand
facility: The Canterbury Geriatric Medical Research Trust, c/- The Princess Margaret Hospital
city: Hamilton
country: New Zealand
facility: Waikato Hospital, Rheumatology
city: Timaru
country: New Zealand
facility: Clinical Trials Unit, Timaru Hospital
city: Callao
country: Peru
facility: Hospital Nacional IV Alberto Sabogal Sologuren
city: Lima
country: Peru
facility: Centro Medico Corpac/Investigaciones en Reumatologia
city: Lima
country: Peru
facility: Instituto Peruano del Hueso y la Articulacion SAC-Privado-Lima/Centro de Investigacion IPHAR
city: Lipa City
country: Philippines
facility: Mary Mediatrix Medical Center
state: Batangas
city: Dasmarinas
country: Philippines
facility: De La Salle University Health Sciences Campus Clinical Epidemiology Unit
state: Cavite
city: Angeles City
country: Philippines
facility: Angeles University Foundation Medical Center
state: Pampanga
city: Cebu City
country: Philippines
facility: Chong Hua Hospital
city: Davao City
country: Philippines
facility: Southern Philippine Medical Center
city: Las Piñas City
country: Philippines
facility: University of Perpetual Help Rizal Dalta Medical Center
city: Manila
country: Philippines
facility: University of Santo Tomas Hospital
city: Bialystok
country: Poland
facility: "ZDROWIE OSTEO-MEDIC" s.c. Lidia I Artur Racewicz, Agnieszka I Jerzy Supronik
city: Bialystok
country: Poland
facility: ClinicMed Badurski i wspolnicy Spolka Jawna
city: Cieszyn
country: Poland
facility: NSZOZ Medicus II
city: Koscian
country: Poland
facility: Szpital im. Teodora Dunina
city: Krakow
country: Poland
facility: Krakowskie Centrum Medyczne NZOZ
city: Poznan
country: Poland
facility: Centrum Badan Klinicznych s.c. Wieslawa Porawska, Lukasz Porawski
city: Sopot
country: Poland
facility: Wojewodzki Zespol Reumatologiczny im. dr Jadwigi Titz-Kosko
city: Torun
country: Poland
facility: Nzoz "Nasz Lekarz"
city: Warszawa
country: Poland
facility: Synexus Polska Sp. z o.o. Oddzial w Warszawie
city: Warszawa
country: Poland
facility: Rheuma-Medicus - Specjalistyczne Centrum Reumatologii i Osteoporozy
city: Wroclaw
country: Poland
facility: SYNEXUS Polska Sp. z.o.o.
city: Ponce
country: Puerto Rico
facility: Ponce School Of Medicine
city: Ponce
country: Puerto Rico
facility: Edificio Parra
city: San Juan
country: Puerto Rico
facility: Mindful Medical Research
city: Bucharest
country: Romania
facility: Spitalul Clinic "Sf. Maria"
city: Iasi
country: Romania
facility: Spitalul Clinic De Recuperare
city: Novosibirsk City
country: Russian Federation
facility: City Clinical Hospital # 1
state: Novosibirsk Region
city: Novosibirsk City
country: Russian Federation
facility: Consultative Diagnostic Rheumatology Center "Healthy Joints", LLC
state: Novosibirsk Region
city: Saint-Petersburg
country: Russian Federation
facility: State Healthcare Institution City Hospital # 40 of Administrative Health Resort District
state: Sestroretsk, Russia
city: Smolensk
country: Russian Federation
facility: Smolensk State Medical Academy
state: Smolensk Region
city: Barnaul
country: Russian Federation
facility: State Healthcare Institution Regional Clinical Hospital
city: Ekaterinburg
country: Russian Federation
facility: State Healthcare Institution
city: Ekaterinburg
country: Russian Federation
facility: State Educational Institution of Higher Professional Education Ural State Medical Academy of Federal
city: Ekaterinburg
country: Russian Federation
facility: State Educational Institution of Higher Professional Education
city: Ekaterinburg
country: Russian Federation
facility: Ltd.Medical Association "Novaya Bolnitsa"
city: Kemerovo
country: Russian Federation
facility: State Healthcare Institution Regional Clinical Hospital for War Veterans
city: Moscow
country: Russian Federation
facility: Russian State Medical University Moscow Faculty City Clinical Hospital #4
city: Moscow
country: Russian Federation
facility: Rheumatology Research Institute of Russian Academy of Medical Sciences
city: Petrozavodsk
country: Russian Federation
facility: GUZ Republican Hospital n.a. Baranov
city: Saint-Petersburg
country: Russian Federation
facility: Federal North-West Medical Research Centre
city: St. Petersburg,
country: Russian Federation
facility: Saint-Petersburg State Budgetary Healthcare Institution "Clinical Rheumathology Hospital #25"
city: St. Petersburg
country: Russian Federation
facility: Clinical Hospital #122 named after L.G. Sokolov of the Federal Medical-Biological Agency
city: St. Petersburg
country: Russian Federation
facility: St. Petersburg State Institution of Healthcare Consultative-diagnostic Center #85
city: Tomsk
country: Russian Federation
facility: Regional State Budget Institution Of Healthcare
city: Tomsk
country: Russian Federation
facility: Regional State Budgetary Healthcare Institution of Tomsk Regional Clinical Hospital
city: Bratislava
country: Slovakia
facility: Reumatologicka ambulancia, Poliklinika Ruzinov
city: Bratislava
country: Slovakia
facility: NOVAPHARM s.r.o -Zeleznicna NaP, Reumatologicka ambulancia
city: Dunajska Streda
country: Slovakia
facility: AAGS, s.r.o. , nestatne zdravotnicke zariadenie
city: Kosice
country: Slovakia
facility: Interna a reumatologicka ambulancia
city: Nove Zamky
country: Slovakia
facility: Ecclesia, s.r.o Reumatologicka ambulancia
city: Piestany
country: Slovakia
facility: Narodny Ustav Reumatickych Chorob
city: Poprad
country: Slovakia
facility: Reumatologicka ambulancia, MUDr. Zuzana Cizmarikova, s.r.o.
city: Rimavska Sobota
country: Slovakia
facility: Reumatologicka ambulancia, REUMEX, s.r.o.
city: Senica
country: Slovakia
facility: Reumatologicka ambulancia, Nestatne zdravotnicke zariadenie
city: Zilina
country: Slovakia
facility: Nestatna reumatologicka ambulancia, MUDr. Pavol Polak s.r.o.
city: Santiago De Compostela
country: Spain
facility: Hospital Nuestra Senora de la Esperanza
state: A Coruna
city: Santiago de Compostela
country: Spain
facility: Hospital Clinico Universitario de Santiago
state: A Coruna
city: Merida
country: Spain
facility: Hospital de Merida
state: Badajoz
city: Santander
country: Spain
facility: Hospital Universitario Marques de Valdecilla
state: Cantabria
city: Barakaldo
country: Spain
facility: Hospital Universitario Cruces
state: Vizcaya
city: Bilbao
country: Spain
facility: Hospital de Basurto
state: Vizcaya
city: Barcelona
country: Spain
facility: Hospital Del Mar
city: Coruna
country: Spain
facility: Complejo Hospitalario Universitario A Coruna
city: Madrid
country: Spain
facility: Hospital Universitario 12 de Octubre
city: Madrid
country: Spain
facility: Hospital Universitario De La Paz
city: Malaga
country: Spain
facility: Hospital Civil. Hospital Regional Universitario Carlos Haya
city: Sevilla
country: Spain
facility: Hospital Universitario Virgen Macarena
city: Sevilla
country: Spain
facility: Hospital Nuestra Señora de Valme
city: Sevilla
country: Spain
facility: Hospital El Tomillar
city: Valencia
country: Spain
facility: Hospital Universitari i Politecnic La Fe de Valencia
city: Falun
country: Sweden
facility: Falu lasarett
city: Jonkoping
country: Sweden
facility: Lanssjukhuset Ryhov
city: Malmo
country: Sweden
facility: Skanes Universitetssjukhus i Malmo Reumamottagningen
city: Sundsvall
country: Sweden
facility: Sundsvalls Sjukhus
city: Umea
country: Sweden
facility: Norrlands Universitetssjukhus
city: Uppsala
country: Sweden
facility: Akademiska University Hospital
city: Niao Sung Hsiang
country: Taiwan
facility: Chang Gung Medical Foundation-
state: Kaohsiung County
city: Kwei-Shan
country: Taiwan
facility: Chang Gung Medical Foundation-Linkou Branch
state: Taoyuan County
city: Changhua
country: Taiwan
facility: Changhua Christian Hospital
city: Kaohsiung
country: Taiwan
facility: Kaohsiung Medical University Chung-Ho Memorial Hospital
city: Kaohsiung
country: Taiwan
facility: Kaohsiung Veterans General Hospital
city: Taichung
country: Taiwan
facility: Taichung Veterans General Hospital
city: Tainan
country: Taiwan
facility: National Cheng Kung University Hospital
city: Taipei
country: Taiwan
facility: National Taiwan University Hospital
city: Taipei
country: Taiwan
facility: Taipei Veterans General Hospital
city: Rajathevee
country: Thailand
facility: Rheumatology Unit, Department of Internal Medicine, Phramongkutklao Hospital
state: Bangkok
city: Amphoe Mueang
country: Thailand
facility: Division of Rheumatology, Department of Internal Medicine, Faculty of Medicine,
state: Chiang MAI
city: Muang District
country: Thailand
facility: Division of Allergy-Immunology-Rheumatology, Department of Medicine, Faculty of Medicine
state: Khonkaen
city: Bangkok
country: Thailand
facility: Rheumatology Unit, Department of Internal Medicine, Rajavithi Hospital
city: Bangkok
country: Thailand
facility: Siriraj Hospital, Mahidol University
city: Bornova
country: Turkey
facility: Ege University Medical Faculty
state: Izmir
city: Ankara
country: Turkey
facility: Hacettepe University Medical Faculty
city: Izmir
country: Turkey
facility: Dokuz Eylul Universitesi Arastirma Uygulama Hastanesi
city: Simferopol
country: Ukraine
facility: Crimean Republican Institution "Clinical Territorial Medical Association "University Clinic",
state: Crimea
city: Kharkiv
country: Ukraine
facility: Municipal Establishment of Health Care "Kharkiv City Clinical Hospital #8", Dept. of Rheumatology
city: Kyiv
country: Ukraine
facility: State Institution Republican Clinical Hospital of the Ministry of Health of Ukraine
city: Kyiv
country: Ukraine
facility: State Establishment "Institute of Gerontology of NAMS of Ukraine n.a. D.F. Chebotareva"
city: Lviv
country: Ukraine
facility: Municipal City Clinical Hospital #4, Policlinic Care
city: Odesa
country: Ukraine
facility: Multifield Medical Center of Odesa National Medical University "University Clinic #1"
city: Odesa
country: Ukraine
facility: Multifield Medical Center of Odesa National Medical University "University Clinic #1"
city: Simferopol Crimea
country: Ukraine
facility: CRIMEAN Republican Institution, "Clinical Hospital n.a. M.O. Semashko"
city: Vinnitsa
country: Ukraine
facility: Vinnitsa Regional Clinical Hospital n.a. Pirogov
city: Zaporizhzhia
country: Ukraine
facility: Municipal Establishment "City Hospital#7of Zaporizhzhia State Medical University
city: Dudley
country: United Kingdom
facility: Dudley Group of Hospitals NHS Trust
state: WEST Midlands
city: Cannock
country: United Kingdom
facility: The Royal Wolverhampton NHS Trust
city: Newcastle Upon Tyne
country: United Kingdom
facility: Royal Victoria Infirmary
city: Wirral
country: United Kingdom
facility: Wirral University Teaching Hospital NHS Foundation Trust-Arrowe Park Hospital
Study officials:
affiliation: Pfizer
name: Pfizer CT.gov Call Center
role: STUDY_DIRECTOR
References:
citation: Mueller RB, Schulze-Koops H, Furst DE, Cohen SB, Kwok K, Wang L, Killeen T, von Kempis J. Effect of dose adjustments on the efficacy and safety of tofacitinib in patients with rheumatoid arthritis: a post hoc analysis of an open-label, long-term extension study (ORAL Sequel). Clin Rheumatol. 2022 Apr;41(4):1045-1055. doi: 10.1007/s10067-021-05908-z. Epub 2022 Jan 1.
citation: Winthrop KL, Curtis JR, Yamaoka K, Lee EB, Hirose T, Rivas JL, Kwok K, Burmester GR. Clinical Management of Herpes Zoster in Patients With Rheumatoid Arthritis or Psoriatic Arthritis Receiving Tofacitinib Treatment. Rheumatol Ther. 2022 Feb;9(1):243-263. doi: 10.1007/s40744-021-00390-0. Epub 2021 Dec 6.
citation: Cohen SB, Tanaka Y, Mariette X, Curtis JR, Lee EB, Nash P, Winthrop KL, Charles-Schoeman C, Wang L, Chen C, Kwok K, Biswas P, Shapiro A, Madsen A, Wollenhaupt J. Long-term safety of tofacitinib up to 9.5 years: a comprehensive integrated analysis of the rheumatoid arthritis clinical development programme. RMD Open. 2020 Oct;6(3):e001395. doi: 10.1136/rmdopen-2020-001395.
citation: van der Heijde D, Landewe RBM, Wollenhaupt J, Strengholt S, Terry K, Kwok K, Wang L, Cohen S. Assessment of radiographic progression in patients with rheumatoid arthritis treated with tofacitinib in long-term studies. Rheumatology (Oxford). 2021 Apr 6;60(4):1708-1716. doi: 10.1093/rheumatology/keaa476.
citation: Panaccione R, Isaacs JD, Chen LA, Wang W, Marren A, Kwok K, Wang L, Chan G, Su C. Characterization of Creatine Kinase Levels in Tofacitinib-Treated Patients with Ulcerative Colitis: Results from Clinical Trials. Dig Dis Sci. 2021 Aug;66(8):2732-2743. doi: 10.1007/s10620-020-06560-4. Epub 2020 Aug 20.
citation: Kaine J, Tesser J, Takiya L, DeMasi R, Wang L, Snyder M, Soma K, Fan H, Bandi V, Wollenhaupt J. Re-establishment of efficacy of tofacitinib, an oral JAK inhibitor, after temporary discontinuation in patients with rheumatoid arthritis. Clin Rheumatol. 2020 Jul;39(7):2127-2137. doi: 10.1007/s10067-020-04956-1. Epub 2020 Feb 12.
citation: Wollenhaupt J, Lee EB, Curtis JR, Silverfield J, Terry K, Soma K, Mojcik C, DeMasi R, Strengholt S, Kwok K, Lazariciu I, Wang L, Cohen S. Safety and efficacy of tofacitinib for up to 9.5 years in the treatment of rheumatoid arthritis: final results of a global, open-label, long-term extension study. Arthritis Res Ther. 2019 Apr 5;21(1):89. doi: 10.1186/s13075-019-1866-2.
citation: Li ZG, Liu Y, Xu HJ, Chen ZW, Bao CD, Gu JR, Zhao DB, An Y, Hwang LJ, Wang L, Kremer J, Wu QZ. Efficacy and Safety of Tofacitinib in Chinese Patients with Rheumatoid Arthritis. Chin Med J (Engl). 2018 Nov 20;131(22):2683-2692. doi: 10.4103/0366-6999.245157.
citation: Hall S, Nash P, Rischmueller M, Bossingham D, Bird P, Cook N, Witcombe D, Soma K, Kwok K, Thirunavukkarasu K. Tofacitinib, an Oral Janus Kinase Inhibitor: Pooled Efficacy and Safety Analyses in an Australian Rheumatoid Arthritis Population. Rheumatol Ther. 2018 Dec;5(2):383-401. doi: 10.1007/s40744-018-0118-2. Epub 2018 Jun 11.
citation: Fleischmann R, Wollenhaupt J, Takiya L, Maniccia A, Kwok K, Wang L, van Vollenhoven RF. Safety and maintenance of response for tofacitinib monotherapy and combination therapy in rheumatoid arthritis: an analysis of pooled data from open-label long-term extension studies. RMD Open. 2017 Dec 18;3(2):e000491. doi: 10.1136/rmdopen-2017-000491. eCollection 2017.
citation: Fleischmann R, Wollenhaupt J, Cohen S, Wang L, Fan H, Bandi V, Andrews J, Takiya L, Bananis E, Weinblatt ME. Effect of Discontinuation or Initiation of Methotrexate or Glucocorticoids on Tofacitinib Efficacy in Patients with Rheumatoid Arthritis: A Post Hoc Analysis. Rheumatol Ther. 2018 Jun;5(1):203-214. doi: 10.1007/s40744-018-0093-7. Epub 2018 Feb 7.
citation: Mariette X, Chen C, Biswas P, Kwok K, Boy MG. Lymphoma in the Tofacitinib Rheumatoid Arthritis Clinical Development Program. Arthritis Care Res (Hoboken). 2018 May;70(5):685-694. doi: 10.1002/acr.23421. Epub 2018 Apr 2.
citation: Cohen SB, Tanaka Y, Mariette X, Curtis JR, Lee EB, Nash P, Winthrop KL, Charles-Schoeman C, Thirunavukkarasu K, DeMasi R, Geier J, Kwok K, Wang L, Riese R, Wollenhaupt J. Long-term safety of tofacitinib for the treatment of rheumatoid arthritis up to 8.5 years: integrated analysis of data from the global clinical trials. Ann Rheum Dis. 2017 Jul;76(7):1253-1262. doi: 10.1136/annrheumdis-2016-210457. Epub 2017 Jan 31.
citation: Genovese MC, van Vollenhoven RF, Wilkinson B, Wang L, Zwillich SH, Gruben D, Biswas P, Riese R, Takiya L, Jones TV. Switching from adalimumab to tofacitinib in the treatment of patients with rheumatoid arthritis. Arthritis Res Ther. 2016 Jun 23;18:145. doi: 10.1186/s13075-016-1049-3.
citation: Winthrop KL, Silverfield J, Racewicz A, Neal J, Lee EB, Hrycaj P, Gomez-Reino J, Soma K, Mebus C, Wilkinson B, Hodge J, Fan H, Wang T, Bingham CO 3rd. The effect of tofacitinib on pneumococcal and influenza vaccine responses in rheumatoid arthritis. Ann Rheum Dis. 2016 Apr;75(4):687-95. doi: 10.1136/annrheumdis-2014-207191. Epub 2015 Mar 20.
citation: Boyle DL, Soma K, Hodge J, Kavanaugh A, Mandel D, Mease P, Shurmur R, Singhal AK, Wei N, Rosengren S, Kaplan I, Krishnaswami S, Luo Z, Bradley J, Firestein GS. The JAK inhibitor tofacitinib suppresses synovial JAK1-STAT signalling in rheumatoid arthritis. Ann Rheum Dis. 2015 Jun;74(6):1311-6. doi: 10.1136/annrheumdis-2014-206028. Epub 2014 Nov 14.