Clinical trial NCT05403177: Marathon of Hope Cancer Centres Network Study for Ontario (MOHCCN-O)
Official title: Marathon of Hope Cancer Centres Network Study for Ontario (MOHCCN-O)
Study type: OBSERVATIONAL
Overall status: RECRUITING
Conditions: Breast Cancer
Colorectal Cancer
Pancreas Cancer
Kidney Cancer
Prostate Cancer
Ovary Cancer
Head and Neck Cancer
Leukemia
Lymphoma
Lung Cancer
Melanoma
Solid Tumor
Lead sponsor: University Health Network, Toronto
Sponsor class: OTHER
Collaborators: name: Princess Margaret Hospital, Canada
name: Ontario Institute for Cancer Research
name: Terry Fox Research Institute
name: Queen's University, Kingston, Ontario
name: Ottawa Hospital Research Institute
name: Queen's University
First posted: 2022-06-03
Enrollment: 500
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Any cancer patient

Brief summary: The Marathon of Hope Cancer Centres Network (MOHCCN) is a national network of cancer centres that pursue collaborative cancer research in precision medicine (an emerging approach for disease treatment and prevention that considers individual variability in DNA, environment and lifestyle) to accelerate the discovery of innovations and improve the health outcomes for cancer patients

Detailed description: The purpose of this study is to use evolving technologies such as genomics and artificial intelligence to study cancer so that the right treatment can be given to the right patient, at the right time. Approximately 15,000 participants will take part in the greater MOHCCN study across Canada in the first 5 years, and ultimately the goal is to enroll up to 100,000 over next 10 years.

Eligibility criteria: Inclusion Criteria:

1. Patients with histological and/or cytological confirmation of blood or solid tumor malignancies. For tumour types where pre-surgical biopsy is not routinely performed to confirm a pathologic diagnosis of cancer, patients may consent to this protocol, but eligibility must be confirmed after pathology is finalized demonstrating presence of malignancy
2. All patients must be able to satisfy the required minimum data elements for the 15k gold standard cohort through:

   1. Already existing data that satisfies the minimal requirements of a gold standard case (refer to Table 1)
   2. Have sufficient biospecimens (tumor and/or blood samples) available for more comprehensive molecular and immunophenotypic characterization
3. Patients who do not satisfy the required minimum data elements but would like to participate, maybe requested to donate blood and undergo a fresh biopsy if the archived Formalin-fixed paraffin-embedded (FFPE) samples are not available, or in cases where a fresh tumor biopsy is deemed necessary for molecular profiling.
4. Participating patients must agree to share their anonymized clinical and genomic data

Exclusion Criteria:

None.

Primary outcomes:
measure: Number of patients included in a pan-Canadian cohort with comprehensive clinical and genomic data
timeFrame: 5 years
Secondary outcomes:
measure: Development of standard practices to create a unique shareable dataset of molecular, imaging, clinical and health outcome information on Canadian cancer cases
timeFrame: 5 years
measure: Clinical effectiveness and cost-effectiveness of precision cancer medicine to advance clinical implementation and reimbursement decisions
timeFrame: 5 years
measure: Development and collection of patient-reported outcomes to enhance patient-centeredness in precision cancer medicine
timeFrame: 5 years
Other outcomes:
Locations:
city: Kingston
country: Canada
facility: Kingston Health Sciences Centre
state: Ontario
city: Ottawa
country: Canada
facility: Ottawa Health Research Institute
state: Ontario
city: Toronto
country: Canada
facility: Princess Margaret Cancer Centre
state: Ontario
Study officials:
affiliation: University Health Network, Toronto
name: Lillian Siu, MD
role: PRINCIPAL_INVESTIGATOR
References: