Clinical trial NCT06355206: Natural Course and Therapeutic Effect of Recurrent Acute Pancreatitis
Official title: Natural Course and Therapeutic Effect of Recurrent Acute Pancreatitis: a Prospective Cohort Study
Study type: OBSERVATIONAL
Overall status: RECRUITING
Conditions: Cohort Study
Recurrent Acute Pancreatitis
Keywords: recurrent acute pancreatitis
natural course
therapeutic effect
Lead sponsor: Changhai Hospital
Sponsor class: OTHER
First posted: 2024-04-09
Enrollment: 2000
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Patients whti recurrent acute pancreatitis come from Changhai Hospital.

Brief summary: The goal of this observational cohort study is to learn about the etiology, natural course, therapeutic effect and outcome of recurrent acute pancreatitis patients. The main question it aims to answer is:

Does endoscopic intervention, surgery or conservative treatment reduce the recurrence of acute pancreatitis? What are the risk factors affecting the recurrence of acute pancreatitis?

Patients will be closely followed and clinical information will be recorded.

Detailed description: Acute pancreatitis is one of the most common causes of acute hospital admission, which is unpredictable and contributes to high health-care costs even death. Recurrent acute pancreatitis is defined as two or more discrete episodes of acute pancreatitis, and has an estimated annual incidence of 8-10 per 100 000. Cholelithiasis, alcohol and Hyperglyceremia are the most commonly recognized causes of acute pancreatitis. About 80% of RAP patients can be identified through routine investigations identify (include proper history, physical examination, CT, MRI, endoscopic ultrasound); however, in up to 20% of cases whose cause remains unclear are known as idiopathic RAP. For RAP patients with clear cause, removal of the cause can effectively reduce or prevent recurrence. For patients with idiopathic RAP, the treatment options are not clear and have been subject to debate. At present, the natural course, outcome and therapeutic effect of RAP is still not clear. Therefore, the prospective cohort can clarify the clinical characteristics of RAP more comprehensively and deeply and to accumulate evidence for treatment.

Eligibility criteria: Inclusion Criteria:

* Patients with recurrent acute pancreatitis.

Exclusion Criteria:

* Unwilling or unable to provide consent.

Primary outcomes:
measure: Recurrence rate of acute pancreatitis
timeFrame: Through study completion, an average of 1 year
Secondary outcomes:
measure: Proportion of patients with different treatment
timeFrame: Through study completion, an average of 1 year
measure: Characteristics of acute pancreatitis
timeFrame: Through study completion, an average of 1 year
measure: Proportion of patients wtih pain in RAP patients
timeFrame: Through study completion, an average of 3 year
measure: Proportion of patients with chronic pancreatitis
timeFrame: Through study completion, an average of 3 year
measure: Evaluation of quality of life
timeFrame: Through study completion, an average of 3 year
measure: Evaluation of psychological condition
timeFrame: Through study completion, an average of 3 year
Other outcomes:
Locations:
city: Shanghai
country: China
facility: Changhai Hospital
state: Shanghai
Study officials:
affiliation: Changhai Hospital
name: Zhaoshen Li, M.D.
role: STUDY_CHAIR
References: