Clinical trial NCT02196870: Effects of Chest Wall Elastance on Pulmonary Mechanics of Acute Respiratory Failure (ARF)
Official title: Physiological Effects of Chest Wall Elastance on Pulmonary Mechanics of Acute Respiratory Failure Patientstranspulmonary Pressure
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Airway Pressure Stress Index
Transpulmonary Pressure Stress Index
Acute Respiratory Failure
Chest Wall Elastance
Keywords: Airway pressure stress index
Transpulmonary pressure stress index
Acute Respiratory Failure
Chest wall elastance
Lung stress
Lead sponsor: Southeast University, China
Sponsor class: OTHER
First posted: 2014-07-22
Enrollment: 12
Sex: ALL
Minimum age (years): 18
Maximum age (years): 85
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: CASE_CONTROL
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: acute respiratory failure patients

Brief summary: Patients with chest wall elastance increasing could worsen lung function. Increasing of chest wall elastance plays a great role in lung mechanics, and could influence mechanical ventilation settings. Therefore, It could help the physicians to find appropriate indicators and optimize the treatments of ARF patients to explore the mechanisms of lung mechanics changse in the patients with high chest wall elastance.

Detailed description: Mechanical ventilation(MV) is an important treatment for acute respiratory failure(ARF) patients, could improve hypoxemia, maintain lung volume and promote alveolar opening. However, because of barotrauma, volutrauma and biotrauma, MV could cause or aggravate acute lung injury not only in acute respiratory distress syndrome(ARDS) patients, but in patients with normal lung function1,2.

Patients with chest wall elastance increasing could worsen lung function. Increasing of chest wall elastance plays a great role in lung mechanics, and could influence mechanical ventilation settings. Therefore, It could help the physicians to find appropriate indicators and optimize the treatments of ARF patients to explore the mechanisms of lung mechanics changse in the patients with high chest wall elastance.

The present study is set out to examine the effects of high chest wall elastance on changes of lung mechanics and the correlation of airway pressure(Paw) stress index and transpulmonary pressure(PL) stress index.

Eligibility criteria: Inclusion Criteria:

* ARF
* mechanical ventilation
* cardiovascular stable

Exclusion Criteria:

* age \< 18y or \> 85y
* pregnancy
* COPD or chronic pulmonary disease

Primary outcomes:
measure: Changes of oxygenation and lung mechanics
timeFrame: up to 24 months
Secondary outcomes:
Other outcomes:
Locations:
city: Nanjing
country: China
facility: Zhongda Hospital
state: Jiangsu
Study officials:
affiliation: Zhongda hospital, Southeast University, Jiangsu, China
name: Jianfeng Xie, Dr.
role: PRINCIPAL_INVESTIGATOR
References:
citation: Pan C, Chen L, Zhang YH, Liu W, Urbino R, Ranieri VM, Qiu HB, Yang Y. Physiological Correlation of Airway Pressure and Transpulmonary Pressure Stress Index on Respiratory Mechanics in Acute Respiratory Failure. Chin Med J (Engl). 2016 Jul 20;129(14):1652-7. doi: 10.4103/0366-6999.185855.