Clinical trial NCT06413251: Clinical Effectiveness of Boxing Training in Individuals With Elevated Blood Pressure or Stage 1 Hypertension
Official title: Boxing Training Effects on Cardiovascular Risk, Quality of Life, Endothelial Function, and Blood Flow Patterns in Individuals With Elevated Blood Pressure or Stage 1 Hypertension
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Elevated Blood Pressure
Hypertension
Lead sponsor: University of Texas, El Paso
Sponsor class: OTHER
First posted: 2024-05-14
Enrollment: 24
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Intervention model description: Participants will be recruited from the University of Texas at El Paso and its surroundings. They will be identified by a preliminary blood pressure screening and a health questionnaire. The inclusion criteria will consist on: (1) ≥18 years old, (2) SBP between 120-139 mmHg or DBP between 80-89 mmHg obtained from 2 different days, (3) an estimated 10-year risk of CVD ≤10%, calculated by the ACC/AHA Pooled Cohort Equations, and (4) no current participation in 3 or more days per week of endurance or resistance exercise training. Exclusion criteria will include non-controlled cardiac, pulmonary, or metabolic diseases, smoking, consumption of nutritional supplements containing antioxidants, and any physical impairment to exercise.
Primary purpose: TREATMENT

Brief summary: The goal of this clinical trial is to determine whether boxing training reduces cardiovascular risk in elevated blood pressure or hypertension stage 1 individuals.

The main questions it aims to answer are (1) if boxing training reduces peripheral and central blood pressure and (2) if boxing training improves cardiovascular function in elevated blood pressure or hypertension stage 1 individuals.

Participants with elevated blood pressure or hypertension stage 1 will be randomly divided into a control group or an intervention group. The latter group will be involved in boxing training, 3 days per week for 6 weeks.

Researchers will compare clinical and cardiovascular outcomes between the control and the intervention group.


Eligibility criteria: Inclusion Criteria:

* ≥18 years old.
* Systolic blood pressure between 120-139 mmHg and/or diastolic blood pressure between 80-89 mmHg obtained from 2 different days.
* an estimated 10-year risk of CVD ≤10%, calculated by the ACC/AHA Pooled Cohort Equations.
* no current participation in 3 or more days per week of endurance or resistance exercise training.

Exclusion Criteria:

* non-controlled cardiac, pulmonary, or metabolic diseases.
* smoking, consumption of nutritional supplements containing antioxidants.
* any physical impairment to exercise.

Primary outcomes:
measure: Change from baseline brachial blood pressure after week six
timeFrame: pre-intervention and immediately after the intervention
Secondary outcomes:
measure: Central Blood Pressure
timeFrame: pre-intervention and immediately after the intervention
measure: Vascular function
timeFrame: pre-intervention and immediately after the intervention
measure: Plethysmography
timeFrame: pre-intervention and immediately after the intervention
measure: Maximum Oxygen Uptake
timeFrame: pre-intervention and immediately after the intervention
measure: Nitric Oxide Bioavailability
timeFrame: pre-intervention and immediately after the intervention
measure: Body Fat Percentage
timeFrame: pre-intervention and immediately after the intervention
measure: Lean Mass
timeFrame: pre-intervention and immediately after the intervention
measure: Quality of Life measured by the short-form 36 (SF-36)
timeFrame: pre-intervention and immediately after the intervention
measure: Arterial Stiffness
timeFrame: pre-intervention and immediately after the intervention
measure: C Reactive Protein (CRP) to assess inflammation
timeFrame: pre-intervention and immediately after the intervention
measure: Interleukin-6 (IL-6) to assess inflammation
timeFrame: pre-intervention and immediately after the intervention
measure: Tumor necrosis factor alfa (TNFα) to assess inflammation
timeFrame: pre-intervention and immediately after the intervention
measure: 8-isoprostane to assess inflammation
timeFrame: pre-intervention and immediately after the intervention
measure: Superoxide dismutase (SOD) to assess oxidative stress
timeFrame: pre-intervention and immediately after the intervention
measure: Total Antioxidant Capacity (TAC) to assess oxidative stress
timeFrame: pre-intervention and immediately after the intervention
measure: Lipid Profile
timeFrame: pre-intervention and immediately after the intervention
measure: Weight
timeFrame: pre-intervention and immediately after the intervention
measure: Height
timeFrame: pre-intervention and immediately after the intervention
Other outcomes:
Locations:
city: El Paso
country: United States
facility: The University of Texas at El Paso
state: Texas
Study officials:
References: