louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT05764499: Physiotherapy Scoliosis Specific Exercise Improves Truncal Shift in Idiopathic Scoliosis
Official title: Physiotherapy Scoliosis Specific Exercise Improves Truncal Shift in Idiopathic Scoliosis: a 24 Month Follow up
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Scoliosis
Apical Deviation
Adolescent Idiopathic Scoliosis
Lead sponsor: Scoliosis SOS Ltd.
Sponsor class: INDUSTRY
First posted: 2023-03-10
Enrollment: 53
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: RETROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Participants were all consecutive patients at the Scoliosis SOS Clinic in London, a private healthcare clinic specializing in non-invasive treatment for Scoliosis. All patients were routinely completing their treatment.

Brief summary: Introduction: Truncal shift caused by scoliosis can be measured with a Formetric Scanner using the Maximal Thoracic Apical Deviation (MTAD) measurement. It is a well-documented complaint with regards to body-image in patients with idiopathic scoliosis (IS). Furthermore, thoracic apical deviation is an important measure in pre-operative assessment and post-operative outcomes.

Objective: The aim of this retrospective cohort study was to determine the long-term effects of an intensive course of Physiotherapy Scoliosis Specific Exercise (PSSE) on MTAD in patients with IS.

Methods: Consecutive IS patients with a single right-sided thoracic curvature who completed an intensive 4-week course of PSSE were recruited. Data was collected between April 2019 and December 2021. All patients were routinely scanned using a Formetric Scanner pre-, immediately post-, 12- and 24-months post-treatment. MTAD, measured in millimetres, was documented. Adults (\>17 years old) (group 1) and children (group 2) were analysed separately.


Eligibility criteria: Inclusion Criteria:

* Patients who completed the group treatment program in its entirety. Patients who have measurements obtained from all necessary time points. Patient who have Scoliosis and who have a primary thoracic curvature.

Exclusion Criteria:

* Patient who did not complete treatment or all measurements obtained. Patients who underwent surgery.

Primary outcomes:
measure: Maximal Thoracic Apical Deviation
timeFrame: Pre-Treatment (Day 1 of treatment), Day 20 of treatment after study completion, an average of four weeks later, 12 months after Post-Treatment, and 24 months after Post-Treatment
Secondary outcomes:
measure: Body Image Score
timeFrame: Pre-Treatment (Day 1 of treatment), Day 20 of treatment after study completion, an average of four weeks later, 12 months after Post-Treatment, and 24 months after Post-Treatment
Other outcomes:
Locations:
city: London
country: United Kingdom
facility: Scoliosis SOS Clinic
Study officials:
References:
Clinical trial NCT05222399: A Study of LY3871801 in Healthy Participants
Official title: Pharmacokinetics of LY3871801 Following Oral Administration of a Crystalline Freebase Tablet and a Solid Dispersion Oral Suspension
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE1
Conditions: Healthy
Lead sponsor: Eli Lilly and Company
Sponsor class: INDUSTRY
First posted: 2022-02-03
Enrollment: 15
Sex: ALL
Minimum age (years): 21
Maximum age (years): 65
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: NON_RANDOMIZED
Intervention model: SEQUENTIAL
Primary purpose: BASIC_SCIENCE

Brief summary: The main purpose of this study is to compare the amount of LY3871801 that gets into the blood stream and how long it takes the body to get rid of it, when given as crystalline freebase tablet (test) and as a solid dispersion oral suspension (reference) in healthy participants. The information about any adverse effects experienced will be collected and the tolerability of LY3871801 will also be evaluated. The study may last up to approximately 15 days excluding the 28 days of screening period.


Eligibility criteria: Inclusion Criteria:

* Participants who are overtly healthy as determined by medical evaluation including medical history and physical examination.
* Have body weight ≥ 45 kilograms (kg) and body mass index (BMI) within the range 18.5 to 40.0 kilograms per meter squared (kg/m²)
* Participants not of childbearing potential

Exclusion Criteria:

* Have known allergies to LY3871801, related compounds or any components of the formulation, or history of significant atopy.
* Have an abnormal blood pressure and/or pulse rate, deemed to be clinically significant by the investigator
* Have used or intend to use prescription or nonprescription medication (including dietary supplements, vitamins, herbal supplements, and/or alternative medicines) within 7 days prior to dosing
* History of drug or alcohol abuse in the past 2 years and/or regularly use known drugs of abuse
* Are unwilling to stop alcohol consumption 24 hours prior to admission and while resident at the clinical research unit (CRU).
* Smoke more than 10 cigarettes per day (or the equivalent, including electronic cigarettes) or are unable to abide by the CRU smoking restrictions.

Primary outcomes:
measure: Pharmacokinetics (PK): Maximum Concentration (Cmax) of LY3871801
timeFrame: Predose through Day 4
measure: PK: Area Under the Plasma Concentration Versus Time Curve From Zero to Infinity (AUC[0-∞]) of LY3871801
timeFrame: Predose through Day 4
Secondary outcomes:
Other outcomes:
Locations:
city: Singapore
country: Singapore
facility: Lilly Centre for Clinical Pharmacology
Study officials:
affiliation: Eli Lilly and Company
name: Call 1-877-CTLILLY (1-877-285-4559) or 1-317-615-4559 Mon - Fri 9 AM - 5 PM Eastern time (UTC/GMT - 5 hours, EST)
role: STUDY_DIRECTOR
References:
Clinical trial NCT06643299: Probiotic Use for Recovery Enhancement From Long COVID-19
Official title: PURE-LC - Probiotic Use for Recovery Enhancement From Long COVID
Study type: INTERVENTIONAL
Overall status: ENROLLING_BY_INVITATION
Phase: PHASE2
Conditions: Post-Acute COVID-19 Syndrome
Keywords: Long COVID
Post-Acute Sequelae of COVID
Lead sponsor: Rush University Medical Center
Sponsor class: OTHER
First posted: 2024-10-16
Enrollment: 180
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: CROSSOVER
Primary purpose: TREATMENT

Brief summary: The goal of this clinical trial is to learn if probiotics can improve symptoms and quality of life in participants with Long COVID. The main questions it aims to answer are:

1. Do probiotics reduce the number and severity of symptoms in those with Long COVID?
2. Do probiotics improve physical and mental health quality of life in those with Long COVID?
3. Do probiotics improve return to work and daily activities in those with Long COVID?

Researchers will compare probiotics to a placebo (a look-alike substance that contains no probiotics) to see if probiotics works to treat Long COVID.

Participants will take the study medication (placebo or probiotic) for 4 months. They will then cross-over (take the other medication) for an additional 4 months. Participants will complete a survey at baseline, 4 months, and 8 months.


Eligibility criteria: Inclusion Criteria:

* Age ≥18 years who report Long COVID with persistent symptoms at the time of study initiation

Exclusion Criteria:

* No longer have symptoms consistent with LC
* Are unable to take the study medication daily
* Are currently pregnant or planning to become pregnant over the course of the study
* Are currently breastfeeding
* Have been diagnosed with an immune-compromising condition
* Are currently taking immunosuppressants
* Do not speak English as a primary language
* Are regularly taking probiotics
* Are enrolled in another Long COVID study with an intervention

Primary outcomes:
measure: Difference in Long COVID Severity
timeFrame: Baseline, Four, and Eight Months
Secondary outcomes:
measure: Difference in LC-SSS Total Score
timeFrame: Baseline, Four, and Eight Months
measure: Difference in Quality of Life
timeFrame: Baseline, Four, and Eight Months
measure: Difference in Return to Work and Activity
timeFrame: Baseline, Four, and Eight Months
Other outcomes:
Locations:
city: Chicago
country: United States
facility: Rush University Medical Center
state: Illinois
Study officials:
References:
Clinical trial NCT06963099: INTACS for Non Ectatic With High Cylinder
Official title: Use of Intra-corneal Ring Segments in Management of Non-ectatic Corneas With High Cylinder
Study type: INTERVENTIONAL
Overall status: RECRUITING
Phase: NA
Conditions: Cornea
Lead sponsor: Sohag University
Sponsor class: OTHER
First posted: 2025-05-08
Enrollment: 50
Sex: ALL
Minimum age (years): 18
Maximum age (years): 60
Standard ages: ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: TREATMENT

Brief summary: Intra-corneal rings implantation for correcting high cylinder errors in non ectatic corneas


Eligibility criteria: Inclusion Criteria:

* Non ectatic corneas with high cylinder error

Exclusion Criteria:

* Corneal ectasia

Primary outcomes:
measure: Change of (1)visual acuity in log mar (2) keratometry readings in diopter 1) refraction. 2)High order aberrations
timeFrame: six months
measure: changes of corneal parameters (K1.K2,K max) in diopter
timeFrame: six months
Secondary outcomes:
Other outcomes:
Locations:
city: Sohag
country: Egypt
facility: Elshimaa A.Mateen
Study officials:
References:
Clinical trial NCT05872399: Greek Physiotherapy Students' Attitudes Towards Psychiatry and Mental Health
Official title: Investigation of Greek Physiotherapy Students' Attitudes Towards Psychiatry and Mental Health
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Students
Physical Therapy
Lead sponsor: University of Thessaly
Sponsor class: OTHER
First posted: 2023-05-24
Enrollment: 204
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: COHORT
Time perspective: CROSS_SECTIONAL
Sampling method: NON_PROBABILITY_SAMPLE
Study population: The study will include physiotherapy students that will have the ability of completing the assessment form.

Brief summary: The main purpose of this study will be to investigate what are the attitudes of Greek physiotherapy students who belong to one of the Higher Educational Institutions of Greece and the correlation of these attitudes with certain demographic characteristics that will be defined.

Detailed description: A link will be created via google forms, which will be made available to undergraduate physiotherapy students of all the departments of the country's universities. The Attitudes Towards Psychiatry - 30 scale will be used to explore students' attitudes towards psychiatry and mental health. Participants through a mandatory field will consent to participate in the study, having read all the necessary information at the beginning. Then the necessary section will be created in which the participant will answer the questions of the assessment scale. The Attitudes Towards Psychiatry - 30 scale has not been standardized in Greek and for this reason it will be translated forward and backward by 2 independent researchers. After the completion of the study, the researchers will collect the results and draw conclusions based on the necessary statistical analyses. The data collection will be done for about one month, the duration of data processing and archiving will be about 6 months.

Eligibility criteria: Inclusion Criteria:

* physiotherapy student in one of the Universities of Greece

Exclusion Criteria:

* not a physiotherapy student at one of the country's Universities

Primary outcomes:
measure: Attitudes Towards Psychiatry - 30
timeFrame: Only one time, at baseline.
Secondary outcomes:
Other outcomes:
Locations:
city: Lamia
country: Greece
facility: University of Thessaly
state: Fthiotis
Study officials:
affiliation: Αcademic fellow
name: Phoebe Speis, Dr.
role: STUDY_DIRECTOR
References:
citation: Connaughton J, Gibson W. Physiotherapy Students' Attitudes toward Psychiatry and Mental Health: A Cross-Sectional Study. Physiother Can. 2016;68(2):172-178. doi: 10.3138/ptc.2015-18E.
citation: Probst M, Peuskens J. Attitudes of Flemish physiotherapy students towards mental health and psychiatry. Physiotherapy. 2010 Mar;96(1):44-51. doi: 10.1016/j.physio.2009.08.006. Epub 2009 Oct 24.
Clinical trial NCT02263599: Conservative Treatment For Ventral Hernia
Official title: Conservative Treatment For Ventral Hernia
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Ventral Hernia
Lead sponsor: Zealand University Hospital
Sponsor class: OTHER
First posted: 2014-10-13
Enrollment: 2089
Sex: ALL
Minimum age (years): 18
Maximum age (years): 120
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: All patients referred to the Surgical Department of Køge University Hospital in the timeperiod from 2009 - 2014 with the diagnosis ventral hernia

Brief summary: The aim of this study is to evaluate on which indication patients are offered operative treatment for their ventral hernia, and to investigate the natural course of ventral hernia in the population of patients not offered operation.


Eligibility criteria: Inclusion Criteria:

All patients (older than 18 years) referred to the Surgical Department of Køge University Hospital from 2009 - 2014 with the diagnosis ventral hernia

Primary outcomes:
measure: Percentage of conservatively treated ventral hernias that undergo surgery
timeFrame: 5 years
Secondary outcomes:
measure: Percentage of patient with ventral hernia that are treated conservatively
timeFrame: 5 years
Other outcomes:
Locations:
city: Køge
country: Denmark
facility: Dept. of Surgery, Køge University Hospital
Study officials:
affiliation: Dept. of Surgery, Køge Hospital
name: Dunja Kokotovic, MS
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT03593499: Expanded Access to Omaveloxolone for Melanoma for Patients Previously Enrolled in 408-C-1401
Study type: EXPANDED_ACCESS
Overall status: NO_LONGER_AVAILABLE
Conditions: Melanoma
Keywords: melanoma
omaveloxolone
expanded access
Lead sponsor: Biogen
Sponsor class: INDUSTRY
First posted: 2018-07-20
Standard ages: CHILD
ADULT
OLDER_ADULT

Brief summary: This is an expanded access program for eligible participants and is designed to provide access to omaveloxolone for the treatment of unresectable or metastatic melanoma to patients who previously participated in the 408-C-1401 (REVEAL) study. To be considered for expanded access, a Principal Investigator from the REVEAL trial should submit a request to Reata Pharmaceuticals on behalf of the individual patient.

Detailed description: Study Sponsor, originally Reata Pharmaceuticals, Inc., is now Reata Pharmaceuticals, Inc., a wholly owned subsidiary of Biogen.

Eligibility criteria: Inclusion Criteria:

-

Exclusion Criteria:

-

Primary outcomes:
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
References:
Clinical trial NCT00989599: Use of Chamomilla Recutita in Phlebitis
Official title: Therapeutic Topic Use of Chamomilla Recutita in Phlebitis Due to Peripheral Intravenous Therapy
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE3
Conditions: Phlebitis
Keywords: phlebitis
Chamomilla recutita
Catheterization peripheral
Lead sponsor: University of Sao Paulo
Sponsor class: OTHER
First posted: 2009-10-05
Enrollment: 123
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: To verify the efficacy of topical applications of Chamomilla recutita infusion for phlebitis treatment, before dose response curve study and pilot study.

Detailed description: The hypothesis adopted was that patients with phlebitis due to peripheral intravenous infusion in anti-neoplasm chemotherapy, treated with a compress of Chamomilla recutita infusion for 20 minutes three times per day, would present a shorter phlebitis regression time in comparison with patients treated with a lukewarm water compress.

Eligibility criteria: Inclusion Criteria:

* Subjects with cancer who had infusion phlebitis during the administration of intravenous chemotherapy peripheral under hospitalization.

Exclusion Criteria:

* Report made by the subject of study, prior hypersensitivity reaction or presentation during the research, adverse reaction to chamomile or any plant of the family Asteraceae ou Compositae: margarida (Aster tripolium), crisântemo (Chrysanthemum leucanthemum), artemísia or isopo santo (Artemísia vulgaris), carpineira or ambrósia americana (Ambrosia artemisiifolia) and senécio (Senecio jacobaea L.);
* Prescription during the process of data collection, some kind of anti-inflammatory with systemic or topical activity where it was located phlebitis, and, upon the occurrence of bacterial phlebitis, had been prescribed topical or systemic antibiotic therapy;
* Refusal of the subject to participate in the study, regardless of the time.

Primary outcomes:
measure: phlebitis regression time
timeFrame: medium of 7 days
Secondary outcomes:
measure: palpable venous cord regression time
timeFrame: 72 hours
Other outcomes:
Locations:
city: Brasília
country: Brazil
facility: Hospital de Base do Distrito Federal
state: Brasília/DF
Study officials:
affiliation: University of Sao Paulo
name: Paula ED Reis, RN, PhD
role: PRINCIPAL_INVESTIGATOR
affiliation: University of Sao Paulo
name: Emília C Carvalho, RN, MsC, PhD
role: STUDY_DIRECTOR
References:
Clinical trial NCT05670899: Retention of CAD Metallic and Poly Ether Ether Ketone (PEEK) Frameworks
Official title: Retention of CAD Metallic and Poly Ether Ether Ketone (PEEK) Frameworks in Mandibular Kennedy Class I Cases: a Randomized Clinical Trial
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Retention
Lead sponsor: Cairo University
Sponsor class: OTHER
First posted: 2023-01-04
Enrollment: 20
Sex: ALL
Minimum age (years): 20
Maximum age (years): 70
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: comparing retention of CAD CAM metallic and Poly Ether Ether Ketone (PEEK) partial dentures in Kennedy class I casses

Detailed description: partially edentulous patients with Kennedy class I classification will be recruited for the trial and then randomly distributed on two groups; experimental group will receive CAD CAM PEEK partial denture and control group will receive CAD CAM metallic partial denture. then primary impressions will be made and then mouth preparation followed by secondary impression then scanning of the master cast using extra-oral scanner then designing the partial denture using blender for dental then the frame work will be printed.

then frame work will be processed into either PEEK or Metal according to randomization.

retention will be measured at zero and 3 months.

Eligibility criteria: Inclusion Criteria:

- Patients with bilateral free end saddles in the mandible (kennedy class I) with last standing abutment premolar.

2- Opposing dentition is fully intact or restored. 3- Sufficient inter-arch space. 4- Angle's class I maxilla-mandibular relationship.

Exclusion Criteria:

1. Periodontal affection of the abutment teeth.
2. Skeletal mal-relation.
3. Unmotivated patients to maintain adequate oral hygiene to follow up.
4. Patients with neuromuscular and Psychiatric disorders.
5. Systematic disease affecting bone and periodontal health.
6. Insufficient inter-arch space.
7. Patients with physical reasons that could affect follow up.

Primary outcomes:
measure: retention
timeFrame: 3 months
Secondary outcomes:
Other outcomes:
Locations:
city: Cairo
country: Egypt
facility: Faculty of Dentistry
state: Manial
Study officials:
References:
Clinical trial NCT01744899: Soleus H-Reflex in Different Sitting Postures
Official title: The Influence of Different Sitting Postures on Soleus H-Reflex in Normal Subjects
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Compression of Spinal Nerve Root
Spinal Disorder
Low Back Pain
Keywords: Lumbosacral spine
Nerve roots
Sitting
H-reflex
Lead sponsor: Texas Woman's University
Sponsor class: OTHER
Collaborators: name: The Saudi Arabian Cultural Mission to the United States
First posted: 2012-12-07
Enrollment: 30
Sex: ALL
Minimum age (years): 18
Maximum age (years): 50
Standard ages: ADULT
Accepts healthy volunteers: yes
Observational model: CASE_CONTROL
Time perspective: CROSS_SECTIONAL
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Healthy adults from both genders.

Brief summary: The purpose of this study was to examine the effect of prolonged sitting duration and three different sitting postures (erect, slumped, and slouched sitting postures) on spinal nerve root function by measuring the soleus (SOL) H-reflex amplitude. In addition, the pressure under the ischial tuberosities during the three sitting postures were assessed and correlated with the SOL H-reflex amplitude.

Detailed description: Participants were assigned to two groups (prolonged sitting group and controls) based on their daily sitting duration with 15 participants in each group. The outcome measures were recorded during erect, slumped and slouched sitting postures. The differences between the two groups and the three sitting postures in the outcome measures were examined for statistical significance.

Eligibility criteria: Inclusion Criteria:

* Able to read, speak, and understand English

Exclusion Criteria:

1. Current complaint of low back pain.
2. Current injury to the ankle and/or foot.
3. Limited ankle movement.
4. Leg length discrepancy.
5. Scoliosis.
6. History of:

   * Back surgery.
   * Calf muscle injury/surgery.
   * Radicular symptoms.
   * Peripheral neuropathy.
   * Upper motor neuron lesion.
   * Systemic and metabolic diseases.
   * Cancer.
7. Pregnant at the time of the study.
8. Use of pain medications at the time of the study.

Primary outcomes:
measure: Lumbosacral nerve root function by as measured by the soleus H-reflex amplitude
timeFrame: The outcome was measured during one session that lasted for an average of 3 hours. No further measurement was performed after that session.
Secondary outcomes:
measure: Pressure under the ischial tuberosities
timeFrame: The outcome was measured during one session that lasted for an average of 3 hours. No further measurement was performed after that session.
Other outcomes:
Locations:
city: Houston
country: United States
facility: Texas Woman's University
state: Texas
Study officials:
affiliation: Texas Woman's University
name: Hamad S Al Amer, MS
role: PRINCIPAL_INVESTIGATOR
References: