Clinical trial NCT02858999: Treatment of Primary Plasma Cell Leukaemia in Subjects Under the Age of 70
Official title: Treatment of Primary Plasma Cell Leukaemia in Subjects Under the Age of 70: Phase II Multicentre Study
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE2
Conditions: Multiple Myeloma
Keywords: primary plasma cell leukaemia
treatment
Lead sponsor: Centre Hospitalier Universitaire, Amiens
Sponsor class: OTHER
First posted: 2016-08-08
Enrollment: 40
Sex: ALL
Minimum age (years): 18
Maximum age (years): 70
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: TREATMENT

Brief summary: Plasma cell leukaemia is a rare variety of multiple myeloma with a poor prognosis. Plasma cell leukaemia is defined as: at least 2,000 circulating plasma cells per µL for a blood leukocyte count higher than 10,000/µL or 20% of plasma cells for a leukocyte count less than 10,000/µL. Plasma cell leukaemia can be either primary, when it constitutes the first manifestation of the disease, or secondary in the setting of relapsed/refractory multiple myeloma. Primary plasma cell leukaemia (PPL) is a rare disease, representing only 1 to 2% of all cases of multiple myelomas at diagnosis. As the annual incidence of multiple myeloma in France is about 4,000 new cases, an estimated 40 to 80 new cases of PPL would be observed each year.

Few data are currently available in the literature concerning the pathophysiology and therapeutic management of PPL, and are derived from retrospective series based small numbers of patients. The prognosis of PPL in response to conventional chemotherapy remains poor with a median survival of 7 to 14 months. However, longer survivals have been obtained with intensive therapy and haematopoietic stem cell transplantation (allogeneic or autologous HSCT).

The investigators propose to perform a prospective study of the management of patients with PPL under the age of 70 years, in combination with a laboratory study: 12 weeks of induction chemotherapy by liposomal Bortezomib-Dexamethasone-Doxorubicin (PAD) alternating with Bortezomib-Dexamethasone-Cyclophosphamide (VCD) for a total of 4 cycles. Peripheral blood stem cell collection after mobilization by G-CSF will be performed after high-dose Cyclophosphamide chemotherapy. Autologous HSCT conditioned by high-dose Melphalan will be performed during the following month for all responding patients. During the 3 months after this first autologous HSCT, allogeneic HSCT with attenuated conditioning will be proposed in patients under the age of 66 years in complete remission with a suitable donor, and another systematic autologous HSCT will be proposed in all other patients. For all patients not treated by allogeneic HSCT, consolidation/maintenance therapy will be performed 3 months after the second autologous HSCT: 4 quarterly consolidations with Bortezomib-Lenalidomide-Dexamethasone (VRD) with maintenance by 2 months of Lenalidomide between these cycles, for a total duration of one year.

The laboratory assessment will consist of blood and bone marrow samples systematically obtained at diagnosis for plasma cell phenotyping by cytometry, cytogenetics, FISH, study of the gene expression profile and SNParray. A DNA bank and plasma bank will be constituted. The investigators also propose to study residual disease by cytometry (after the first autologous HSCT, before and at the end of the consolidation/maintenance phase), as it increasingly appears to have a major impact on survival in multiple myeloma.


Eligibility criteria: Inclusion Criteria:

* Patient with primary plasma cell leukaemia corresponding to the International Myeloma Working Group definition.
* Patient not previously treated apart from a short course of corticosteroid therapy (dexamethasone 40 mg/day for 4 days).
* Age ≥ 18 years and \< 70 years.
* Patient able to provide signed informed consent.
* Effective contraception when justified (oral contraception/protected intercourse).

Exclusion Criteria:

* Consent not obtained.
* Patient under judicial protection, or permanent or temporary guardianship.
* Previously treated multiple myeloma, secondary plasma cell leukaemia.
* ECOG performance status \> 2.
* History of severe psychiatric illness, severe renal failure not attributable to PPL, heart failure (ejection fraction \< 40%), bilirubin \> 3N, transaminases or gamma GT \> 4N.
* Peripheral neuropathy \> NCI grade 2.
* Contraindication to high-dose corticosteroids, cyclophosphamide and anthracyclines.
* Hypersensitivity to bortezomib or lenalidomide.
* Pregnant woman or nursing mothers.
* Malignant disease except for basal cell carcinoma or cervical carcinoma in situ.
* Positive HIV serology; active hepatitis B or C.
* Participation in a clinical trial during the 60 days prior to inclusion.
* Patient not covered by French national health insurance.

Primary outcomes:
measure: Disease-free survival
timeFrame: 3 years
Secondary outcomes:
Other outcomes:
Locations:
city: Aix-en-Provence
country: France
facility: CH Pays d'Aix
city: Amiens
country: France
facility: CHU Amiens
city: Besançon
country: France
facility: CHU Besançon
city: Caen
country: France
facility: CHU Caen
city: Clermont Ferrand
country: France
facility: CHU Clermont Ferrand
city: Dijon
country: France
facility: CHU Dijon
city: Dunkerque
country: France
facility: CH Dunkerque
city: Lille
country: France
facility: CHRU Lille
city: Lyon
country: France
facility: Hospices Civils de Lyon
city: Nancy
country: France
facility: CHU Nancy
city: Nantes
country: France
facility: CHU Nantes
city: Nice
country: France
facility: CHU Nice
city: Paris
country: France
facility: AP-HP
city: Poitiers
country: France
facility: CHU Poitiers
city: Rennes
country: France
facility: CHU Rennes
city: Strasbourg
country: France
facility: CHU Strasbourg
city: Toulouse
country: France
facility: CHU Toulouse
city: Tours
country: France
facility: CHU Tours
Study officials:
affiliation: CHU Amiens
name: Bruno ROYER, PhD
role: PRINCIPAL_INVESTIGATOR
References: