Clinical trial NCT06544252: Pre-exercise Ingestion of a Low Glycaemic Index Rice-based Mixed Meal Increases Fat Oxidation and Endurance Running in a Hot-humid Environment
Official title: Pre-exercise Ingestion of a Low Glycaemic Index Rice-based Mixed Meal Increases Fat Oxidation and Endurance Running in a Hot-humid Environment
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Healthy
Trained Athletes
Lead sponsor: Universiti Sains Malaysia
Sponsor class: OTHER
First posted: 2024-08-09
Enrollment: 12
Sex: MALE
Minimum age (years): 18
Maximum age (years): 35
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: CROSSOVER
Intervention model description: The present study employed a randomised, single-blind, cross-over trial design consisting of two experimental trials separated by a one-week washout period to minimise carryover effects, conducted under hot-humid (32°C, 65% RH) conditions.. The participants were randomised into two groups, each comprising six participants. Six participants were randomised to receive low glycaemic index, and the other six participants received high glycaemic index pre-exercise dietary interventions, followed by a cross-over with the opposing dietary intervention after one week.
Primary purpose: TREATMENT

Brief summary: The objective of this research is to determine the influence of low and high glycemic index Malaysian pre-exercise mixed meals on endurance exercise performance in a hot-humid environment. Glycemic index (GI) is a method used to classify CHO-containing foods based on their influence on postprandial blood glucose when compared to the response on blood glucose after ingesting the same amount of CHO from a reference food (glucose or bread). Low GI (LGI) foods are digested and absorbed more slowly as compared to high GI (HGI) foods, resulting in a stable rise in blood glucose levels.

The participants were trained male endurance long-distance runners. On the day of experimental trials, they consumed pre-exercise rice-based mixed meal, either LGI or HGI 3 hours before endurance running exercise. After that, they ran for 45 minutes at constant running speed equivalent to 70% VO2peak, followed by 10km time-trial. The respiratory gases, blood measures, rectal and skin temperature were measured throughout the running test.


Eligibility criteria: Inclusion Criteria:

* healthy
* age 18-35 years old
* trained (peak oxygen consumption (V̇O2peak): ≥ 55 mL.kg-1.min-1)
* training volume (\&gt;150 min, ≥ three times per week)
* competing at the national level
* \&gt;2-year of running experience
* tier 2 (trained) or tier 3 (highly trained) runners (McKay et al. 2022)
* no allergies to any test foods

Exclusion Criteria:

* diagnosis of chronic diseases (i.e. diabetes mellitus, hypertension, cardiovascular disease)
* bone, muscle or joint impairments
* on medication
* currently smoking
* use of illicit drugs
* use of dietary supplements
* on any particular diet

Primary outcomes:
measure: Time to complete 10 km time-trial
timeFrame: Up to 1 hour
Secondary outcomes:
measure: Fat and carbohydrate oxidation
timeFrame: Up to 2 hours
measure: Capillary blood glucose
timeFrame: Up to 5 hours
measure: Serum insulin
timeFrame: Up to 5 hours
measure: Serum cortisol
timeFrame: Up to 5 hours
measure: Serum lactate
timeFrame: Up to 2 hours
measure: Heart rate
timeFrame: Up to 2 hours
measure: Thermoregulatory measure
timeFrame: Up to 2 hours
Other outcomes:
Locations:
city: Kepala Batas
country: Malaysia
facility: Department of Community Health, Advanced Medical and Dental Institute
state: Penang
Study officials:
affiliation: Department of Community Health, Advanced Medical and Dental Institute, Universiti Sains Malaysia, Bertam, 13200, Kepala Batas, Pulau Pinang, Malaysia
name: Ahmad Munir Che Muhamed, PhD
role: PRINCIPAL_INVESTIGATOR
References: