Clinical trial NCT06876870: MR-Evaluation of Renal Function in Anesthetized Pediatric Patients
Official title: MR-Evaluation of Renal Function in Anesthetized Pediatric Patients
Study type: INTERVENTIONAL
Overall status: NOT_YET_RECRUITING
Phase: PHASE4
Conditions: Renal Blood Flow
Anesthesia
MRI
Renal Oxygenation
Keywords: Renal Blood flow
Anesthesia
Pediatric
MRI
Lead sponsor: Uppsala University
Sponsor class: OTHER
Collaborators: name: Uppsala University Hospital
First posted: 2025-03-14
Enrollment: 50
Sex: ALL
Minimum age (years): 1
Maximum age (years): 14
Standard ages: CHILD
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Intervention model description: Patients are randomized to one out of two possible methods of maintenance anesthesia
Primary purpose: BASIC_SCIENCE

Brief summary: The goal of this study is to investigate the effect of the anesthetic agents sevoflurane or propofol on the blood flow and oxygen delivery to the kidneys.

Pediatric patients who are planned to undergo an MRI scan with generalized anesthesia will be randomized to either IV anesthesia with propofol or inhalation anesthesia with sevoflurane. Both of these anesthetic methods are commonly used for anesthesia on an everyday basis.

In addition to the clinically indicated MRI, Multiparametric MRI will be performed to visualize the effect of the anesthetic agent on renal blood flow, perfusion and oxygenation.

Detailed description: See the study protocol

Eligibility criteria: Inclusion Criteria:

* Pediatric Patients (1 month -14 years of age)
* Indicated for MRI with anesthesia
* ASA (American Society of Anesthesiologists) physical status I-III

Exclusion Criteria:

* Known renal impairment or chronic kidney disease
* Severe cardiac or pulmonary disease
* Allergy to either Propofol or Sevoflurane
* Contraindications to Magnetic Resonance Imaging
* Contraindications to either Propofol or Sevoflurane
* Declined participation or declined consent from patients, parents or guardians
* Ongoing acute kidney injury

Primary outcomes:
measure: Differences in RBF, as measured by phase contrast imaging with mpMRI, between propofol and sevoflurane anesthesia.
timeFrame: The extra imaging is expected to take 20-30 minutes.
Secondary outcomes:
measure: Differences in regional renal tissue perfusion, as measured by arterial spin labelling (ASL) with mpMRI, between propofol and sevoflurane anaesthesia
timeFrame: The whole MpMRI will take around 20-30 minutes all together where the primary and secondary outcomes can later be extracted via analysis of the images
measure: Differences in regional and global renal oxygenation, as measured by Blood Oxygen Level Dependent (BOLD) signal via mpMRI, between propofol and sevoflurane anaesthesia.
timeFrame: The whole MpMRI will take around 20-30 minutes all together where the primary and secondary outcomes can later be extracted via analysis of the images
measure: The difference in relation of RBF to systemic non-invasive blood pressure, between propofol and sevoflurane anaesthesia
timeFrame: The entire MpMRI will take around 20-30 minutes all together where the primary and secondary outcomes can later be extracted via analysis of the images
measure: The difference plasma renin concentration, measured by a blood sample, between propofol and sevoflurane anaesthesia
timeFrame: 1 minute
Other outcomes:
Locations:
Study officials:
affiliation: Istitution of Surgical Sciences, Anesthesiology and Intensive Care
name: Robert Frithiof, Professor
role: STUDY_CHAIR
References: