Clinical trial NCT03780218: Evaluation of Pulmonary Function in Burn Injury
Official title: Evaluation of Pulmonary Function and Respiratory Muscle Strength in Patients With Burn Injury.
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Burns
Keywords: Burn Injury
Pulmonary function
Respiratory muscle
Peripheral muscle
Lead sponsor: Hacettepe University
Sponsor class: OTHER
Collaborators: name: Ankara City Hospital Bilkent
First posted: 2018-12-19
Enrollment: 94
Sex: ALL
Minimum age (years): 18
Maximum age (years): 65
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: CASE_CONTROL
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Experimental group: Patients with burn injury Control Group: Healthy subjects

Brief summary: This study evaluates the pulmonary function, respiratory muscle strength and peripheral muscle strength in patients with burn injury on the week that they will be discharge from the hospital. Healthy subjects will be evaluated for pulmonary function, respiratory muscle strength and peripheral muscle strength.

Detailed description: Burn injures have adverse effect on the respiratory system.In addition to burn injury prolonged hospitalization may increase the ratio of respiratory complications. But, there are no information in the literature about pulmonary function, respiratory muscle strength and peripheral muscle strength in patients with burn injury. Especially, when the patients are discharged from the hospital, it is not known whether the patients are at the same level in terms of pulmonary functions respiratory muscle strength and peripheral muscle strength with healthy individuals. This study will assess pulmonary functions respiratory muscle strength and peripheral muscle strength in patients with burn injury compared to healthy subjects.

Eligibility criteria: Inclusion Criteria:

* Having a burn injury
* Treatment by an inpatient
* able and willing to complete the informed consent process.
* Control group consists of healthy adults with the similar demographic characteristics as experimental group

Exclusion Criteria:

* having a pulmonary system disease
* having a cardiac system disease
* to do regular sports for the last three months

Primary outcomes:
measure: Forced Vital Capacity
timeFrame: 15 minutes
measure: Forced Expiratory Volume in 1 Second
timeFrame: 15 minutes
measure: Forced Expiratory Volume in 1 Second / Forced Vital Capacity
timeFrame: 15 minutes
measure: Maximal Inspiratory Pressure
timeFrame: 15 minutes
measure: Maximal Expiratory Pressure
timeFrame: 15 minutes
Secondary outcomes:
measure: Peak Expiratory Flow
timeFrame: 15 minutes
measure: forced expiratory flow
timeFrame: 15 minutes
measure: Peripheral strength
timeFrame: 15 minutes
measure: Pain severity
timeFrame: 15 minutes
measure: Functional Exercise Capacity
timeFrame: 10 minutes
Other outcomes:
Locations:
city: Ankara
country: Turkey
facility: Ozden Ozkal
Study officials:
affiliation: Hacettepe University
name: Ozden Ozkal
role: PRINCIPAL_INVESTIGATOR
References:
citation: Ozkal O, Topuz S, Karahan S, Erdem MM, Konan A, Yasti AC. Clinical predictors of pulmonary functions, respiratory/peripheral muscle strength and exercise capacity at discharge in adults with burn injury. Disabil Rehabil. 2021 Oct;43(20):2875-2881. doi: 10.1080/09638288.2020.1720320. Epub 2020 Jan 30.