Clinical trial NCT00526747: Erythropoietin Resistance in Anemia of Chronic Kidney Disease
Official title: Novel Biomarkers of Erythropoietin Resistant Anemia Among Patients With Chronic Kidney Disease
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Anemia
Kidney Failure
Erythropoietin
Lead sponsor: Duke University
Sponsor class: OTHER
First posted: 2007-09-10
Enrollment: 32
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Sampling method: NON_PROBABILITY_SAMPLE
Study population: CKD anemia clinic patients

Brief summary: Our goal of this pilot project is to identify inflammatory biomarkers that correlate with epo-resistance among CKD patients.


Eligibility criteria: Inclusion Criteria:

* prevalent patients greater than or equal to 18 years old with CKD defined as a glomerular filtration rate \< 60 cc/min

Exclusion Criteria:

* active GI bleeding or history of GI bleed in the prior 3 months
* uncontrolled hyperparathyroidism (PTH\>500)
* untreated iron deficiency (transferrin saturation \< 20% and ferritin \< 100
* overt infection
* active hemolysis
* hemoglobinopathies
* known adverse response to erythropoietin
* prior kidney transplant
* aluminum toxicity

Primary outcomes:
Secondary outcomes:
Other outcomes:
Locations:
city: Durham
country: United States
facility: Durham Nephrology Anemia Clinic
state: North Carolina
city: Durham
country: United States
facility: Duke University Medical Center Anemia Clinic
state: North Carolina
Study officials:
affiliation: Duke University
name: Jula Inrig, MD, MHS
role: PRINCIPAL_INVESTIGATOR
affiliation: Duke University
name: Lynda Szczech, MD
role: PRINCIPAL_INVESTIGATOR
affiliation: Duke University
name: Suzanne K Bryskin, MD
role: PRINCIPAL_INVESTIGATOR
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