Clinical trial NCT03009318: MRS and 11C-methionine PET/CT in the Diagnosis of Glioma
Official title: Combination of 11C-MET PET and MRS in the Diagnosis of Glioma.
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Glioma
Keywords: Glioma
Magnetic resonance spectroscopy
Methionine
PET/CT
Lead sponsor: Huashan Hospital
Sponsor class: OTHER
First posted: 2017-01-04
Enrollment: 100
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: DIAGNOSTIC

Brief summary: MET PET and MRS are often performed as imaging tool for the differential diagnosis of gliomas. But both techniques have limitations causing misdiagnosis; thus, the investigators tried to combine these two imaging tools to study whether the combination of MET PET and MRS could raise the diagnosis ability of the radiological diagnosis of gliomas.


Eligibility criteria: Inclusion Criteria:

1. Patients with non-enhancing supratentorial lesions shown by contrast-enhanced MRI
2. No surgery, chemotherapy or radiotherapy history
3. All patients gave written informed consent.

Exclusion Criteria:

1. Patients with infratentorial Neoplasms
2. Patients with enhancing supratentorial lesions
3. Recurrent gliomas after surgery
4. Primary gliomas with history of radiotherapy or chemotherapy
5. History of malignant tumours at any body site
6. Inability to give informed consent

Primary outcomes:
measure: Sensitivity of the combination of MRS and 11C-MET PET/CT
timeFrame: 5 years
Secondary outcomes:
measure: The relationship between 11C-MET PET/CT results and molecular pathogeneses
timeFrame: 5 years
Other outcomes:
Locations:
city: Shanghai
country: China
facility: Huashan hospital, Fudan university
Study officials:
affiliation: Huashan Hospital, Sudan University
name: Dongxiao Zhuang, Professor
role: PRINCIPAL_INVESTIGATOR
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