Clinical trial NCT06489847: An Objective Assessment Tool for Evaluating Functioning in Older Adults
Official title: An Objective Assessment Tool for Evaluating Functioning in Older Adults
Study type: OBSERVATIONAL
Overall status: RECRUITING
Conditions: Alzheimer Disease
Keywords: Alzheimer's Disease
Mild Cognitive Impairment
Lead sponsor: Stanford University
Sponsor class: OTHER
Collaborators: name: University of Massachusetts, Worcester
First posted: 2024-07-08
Enrollment: 30
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Healthy Adults

Brief summary: The Investigators are seeking your consent to participate in research investigating the development of a mobile application that enhances physical and cognitive assessments.

This is in response to the growing significance of the Short Physical Performance Battery (SPPB) in Alzheimer's Disease and Related Dementias (AD/ADRD) research. The SPPB has proven its value in evaluating lower extremity function and mobility in older adults, providing predictive insights into declines in daily living activities, falls, hospitalization, disability, and mortality.

Recognizing the need for accessible and automated assessment tools, this project endeavors to design a mobile app with multi-fold functionality. The final version will guide users through SPPB tests, offer real-time performance scoring, and facilitate frequent, objective, and accurate physical and cognitive assessments. This is particularly critical for monitoring the progression of ADRD, identifying subtle physical changes indicative of cognitive decline, and enabling timely interventions tailored to patients' evolving needs.

Our goal is to collect video data from 20 to 30 participants 18+ years of age who are considered healthy with no severe mobility issues to perform the SPPB. The video data will be used to develop a prototype of the SPPB application and validate testing in the lab. The video recording will be automatically encrypted and securely uploaded to Stanford privacy protected computer servers to test and refine the application results.

Detailed description: In response to the growing significance of the Short Physical Performance Battery (SPPB) in Alzheimer's Disease and Related Dementias (AD/ADRD) research, this project aims to create a mobile application that enhances physical and cognitive assessments. The SPPB has proven its value in evaluating lower extremity function and mobility in older adults, providing predictive insights into declines in daily living activities, falls, hospitalization, disability, and mortality. Moreover, recent research has revealed the potential of SPPB in detecting cognitive decline through gait and hand movement analysis at various stages of AD and Mild Cognitive Impairment (MCI). Recognizing the need for accessible and automated assessment tools, this project endeavors to design a mobile app with multi-fold functionality. It will guide users through SPPB tests, offer real-time performance scoring, and facilitate frequent, objective, and accurate physical and cognitive assessments. This is particularly critical for monitoring the progression of ADRD, identifying subtle physical changes indicative of cognitive decline, and enabling timely interventions tailored to patients' evolving needs.

Eligibility criteria: Inclusion Criteria:

* Adult (18+)
* proficient in English
* consider themselves healthy
* Ability to participate in a meeting for consenting and video data collection on Stanford campus

Exclusion Criteria:

* We will exclude participant that do not consent to video data collection
* Under the age of 18
* limited physical mobility.

We have no exclusions on the basis of gender or ethnic background.

Primary outcomes:
measure: develop an automated analysis of the SPPB clinical tests
timeFrame: 1 year
measure: large-scale data collection to continuously collect data for understanding NPS disease trajectories
timeFrame: 1 year
measure: SPPB++ mobile phone app
timeFrame: 1 year
Secondary outcomes:
Other outcomes:
Locations:
city: Palo Alto
country: United States
facility: Clinical Excellence Research Center
state: California
Study officials:
affiliation: Stanford University
name: Ehsan Adeli, PhD
role: PRINCIPAL_INVESTIGATOR
References: