Clinical trial NCT05889754: Reliability and Validity of the Turkish Version of the PedHAL
Official title: The Validity and Reliability of the Turkish Version of the "Pediatric Haemophilia Activities List - Short - PedHALshort" Questionnaire
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Hemophilia
Hemophilia A, Severe
Hemophilia B
Keywords: Functional independence
Activities of daily living
Hemophilia
Factor VIII
Factor IX
Lead sponsor: Hasan Kalyoncu University
Sponsor class: OTHER
First posted: 2023-06-05
Enrollment: 50
Sex: MALE
Minimum age (years): 4
Maximum age (years): 17
Standard ages: CHILD
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Pediatric group hemophilia A and hemophilia B children living in Gaziantep constitute the study population.

Brief summary: This study aimed to establish the validity and reliability of the Turkish version of the Pediatric Haemophilia Activities List (short - PedHALshort) questionnaire.

Detailed description: Hemophilia is a blood disease characterized by a bleeding disorder that develops due to the deficiency of clotting factor VIII (Hamophilia A) or coagulation factor IX (Hamophilia B) proteins that provide clotting in the blood. In the hereditary disease showing X-linked recessive inheritance, female individuals are carriers and male individuals show a clinical picture. Although the clinical picture changes depending on the duration and frequency of bleeding, the severity of the disease is classified as severe, moderate and mild. Musculoskeletal problems are the most common complications in patients with severe and moderate hemophilia. Hemarthroses due to bleeding in the joint (80%) and hematomas due to intramuscular bleeding (20%) cause joint degeneration and muscle atrophy. Recurrent hemarthroses occur when there is not enough clotting factor in the setting, often before the previous hemarthrosis has resolved. This creates a vicious cycle of bleeding-inflammation-rebleeding known as the "target joint". The resulting vicious circle causes permanent damage to bone and cartilage structures and causes "arthropathy". The knee is the joint region where hemarthrosis and arthropathy are most common, followed by the elbow and ankle joints. Since these joints in the musculoskeletal system contain more synovial tissue than the others, they are more exposed to trauma and load and are injured. As a result of all these, pain, joint limitations and muscle strength losses occur. All these clinical findings lead to a decrease in functional independence in activities of daily living with the restriction of physical activity in patients.

In the literature, there are questionnaires and measurement methods in which many functional evaluations are made for hemophilia patients. However, most of them have not been validated and reliable in Turkish. For this purpose, our study aimed to establish the validity and reliability of the Turkish version of the Pediatric Haemophilia Activities List (PedHALshort) questionnaire.

Eligibility criteria: Inclusion Criteria:

* Having been diagnosed with Hemophilia by a physician (Factor VIII-IX)
* Ages 4-17 years old
* Receiving regular prophylactic treatment
* Children who volunteered to participate in the study and whose family consent was given

Exclusion Criteria:

- Children with neurological signs that limit activities of daily living

Primary outcomes:
measure: Paediatric Haemophilia Activities List
timeFrame: through of the study, average 6 months
measure: FISH
timeFrame: through of the study, average 6 months
Secondary outcomes:
Other outcomes:
Locations:
city: Gaziantep
country: Turkey
facility: Hasan Kalyoncu University
state: Şahinbey
Study officials:
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