Clinical trial NCT01058213: Nurse Managed Sequential Strength Training and Bicycle Training in Chronic Obstructive Pulmonary Disease (COPD)
Official title: Nurse Managed Sequential Resistance Then Aerobic Training in COPD
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE2
Conditions: Chronic Obstructive Pulmonary Disease
Keywords: COPD
Pulmonary rehabilitation
Resistance Training
Aerobic Training
Dyspnea
Lead sponsor: University of Illinois at Chicago
Sponsor class: OTHER
First posted: 2010-01-28
Enrollment: 354
Sex: ALL
Minimum age (years): 46
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: This is a 16 week exercise training program for people with severe to very severe chronic obstructive pulmonary disease (COPD). The purpose of this study is to find out if performing strength training prior to initiating exercise training on a stationary bicycle is associated with greater gains in functional status than bicycle training alone or concurrent bicycle and strength training together.

Detailed description: Volunteers are randomly assigned to one of three groups: 1). 8 weeks of resistance (strength) training followed by 8 weeks of bicycle exercise training, 2). 8 weeks of chair exercise followed by 8 weeks of resistance (strength) training and bicycle exercise training, or 3). 8 weeks of chair exercise followed by 8 weeks of bicycle exercise training. The length of the training is 16 weeks for all 3 groups. Volunteers train 3 days per week in our lab located in the Chicagoland area and are supervised by an exercise specialist.

Eligibility criteria: Inclusion Criteria:

* FEV1/FVC \< 70 and FEV1 \< 55%,
* \> 45 years of age,
* experience dyspnea with exertion,
* stable clinical condition (Stable clinical condition is defined as free of respiratory tract infections for at least two months prior to enrollment, no recent change in the color, consistency, or quantity of sputum, afebrile and no recent change in medical therapy.)

Exclusion Criteria:

* evidence of restrictive lung disease or asthma,
* acute respiratory infection,
* taking oral corticosteroids on a regular basis,
* \>3 exacerbations in the previous year,
* currently participating in pulmonary rehabilitation,
* the presence of a potentially debilitating disease or the presence of a condition that would make it potentially unsafe to exercise.
* We will adhere to the American College of Sports Medicine guidelines and exclude those who do not meet their guidelines for exercise testing and training.
* Pregnant women or women who plan to become pregnant during the study.

Primary outcomes:
measure: functional capacity for aerobic exercise and for common daily activities
timeFrame: baseline, 16 weeks
measure: functional reserve as measured by the reduction in breathlessness and fatigue
timeFrame: baseline, 16 weeks
Secondary outcomes:
measure: functional performance and functional capacity utilization as measured by the Functional Performance Inventory and the CHAMPS Physical Activity Scale for Older Adults
timeFrame: baseline, 16 weeks
Other outcomes:
Locations:
city: Chicago
country: United States
facility: University of Illinois at Chicago
state: Illinois
Study officials:
affiliation: University of Illinois at Chicago
name: Margaret K Covey, PhD, RN
role: PRINCIPAL_INVESTIGATOR
References:
citation: Covey MK, Collins EG, Reynertson SI, Dilling DF. Resistance training as a preconditioning strategy for enhancing aerobic exercise training outcomes in COPD. Respir Med. 2014 Aug;108(8):1141-52. doi: 10.1016/j.rmed.2014.06.001. Epub 2014 Jun 11.