Clinical trial NCT04474249: Follow-up of Critical COVID-19 Patients
Official title: Uppföljning av Patienter Som intensivvårdats för COVID-19
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: COVID19
ARDS
AKI
Circulatory Failure
Coagulation Disorder
Inflammatory Response
Keywords: Corona virus
Acute Kidney Injury
SARS
Vasopressor
Respiratory failure
Lead sponsor: Uppsala University
Sponsor class: OTHER
Collaborators: name: Uppsala University Hospital
First posted: 2020-07-16
Enrollment: 300
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Adult patients admitted to ICU for COVID-19.

Brief summary: The study will follow COVID-19 patients who required intensive care after 3-6 months and one year after discharge from the ICU with functional level as well as organ function to assess recovery after COVID-19. Blood and urine will be collected for biobanking.

Detailed description: The study will follow COVID-19 patients who required intensive care at Uppsala University Hospital and were included in the Uppsala COVID-19 biobank. The patients will be contacted after three to six months for a first follow-up with assessment of functional level in activities of daily life, psychiatric symptoms, neurological symptoms and working capacity as well as specific organ functions. The organ functions will include circulation, respiration, coagulation, immune function and kidney function. In addition, blood and urine will be collected for biobanking.

Eligibility criteria: Inclusion Criteria:

* PCR-verified Covid-19
* Treated in ICU

Exclusion Criteria:

* Pregnant of breastfeeding

Primary outcomes:
measure: Mortality
timeFrame: Within 90 days after admission to ICU.
measure: Mortality
timeFrame: Within 1 year after admission to ICU.
measure: Renal recovery
timeFrame: At follow-up three to six months after ICU discharge.
measure: Renal recovery
timeFrame: At follow-up one year after ICU discharge.
measure: Respiratory recovery
timeFrame: Three to six months from discharge from ICU
measure: Working capacity
timeFrame: Three to six months from discharge from ICU
measure: Quality of life score
timeFrame: Three to six months from discharge from ICU
measure: Cognitive recovery
timeFrame: Three to six months from discharge from ICU
measure: Frailty
timeFrame: Three to six months from discharge from ICU
measure: Activities of Daily Life
timeFrame: Three to six months from discharge from ICU
measure: Anxiety
timeFrame: Three to six months from discharge from ICU
measure: Depression
timeFrame: Three to six months from discharge from ICU
measure: Neurological recovery
timeFrame: Three to six months from discharge from ICU
Secondary outcomes:
Other outcomes:
Locations:
city: Uppsala
country: Sweden
facility: Uppsala University Hospital
Study officials:
References:
citation: E E, R F, Oi E, Im L, M L, S R, E W, C J, M H, A M. Impaired diffusing capacity for carbon monoxide is common in critically ill Covid-19 patients at four months post-discharge. Respir Med. 2021 Jun;182:106394. doi: 10.1016/j.rmed.2021.106394. Epub 2021 Apr 15.
citation: Hultstrom M, Lipcsey M, Wallin E, Larsson IM, Larsson A, Frithiof R. Severe acute kidney injury associated with progression of chronic kidney disease after critical COVID-19. Crit Care. 2021 Jan 25;25(1):37. doi: 10.1186/s13054-021-03461-4. No abstract available.
citation: Hultstrom M, Lipcsey M, Morrison DR, Nakanishi T, Butler-Laporte G, Chen Y, Yoshiji S, Forgetta V, Farjoun Y, Wallin E, Larsson IM, Larsson A, Marton A, Titze JM, Nihlen S, Richards JB, Frithiof R. Dehydration is associated with production of organic osmolytes and predicts physical long-term symptoms after COVID-19: a multicenter cohort study. Crit Care. 2022 Oct 21;26(1):322. doi: 10.1186/s13054-022-04203-w.