Clinical trial NCT03222999: Korean Cardiac Arrest Research Consortium
Official title: Korean Cardiac Arrest Research Consortium
Study type: OBSERVATIONAL
Overall status: RECRUITING
Conditions: Out-of-Hospital Cardiac Arrest
Keywords: Out-of-Hospital Cardiac Arrest
Lead sponsor: Korean Cardiac Arrest Research Consortium
Sponsor class: OTHER
First posted: 2017-07-19
Enrollment: 30000
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: CASE_ONLY
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: EMS treated OHCA who visits study participating ED

Brief summary: This study will evaluated the epidemiology and the outcomes of patients suffering out-of-hospital cardiac arrest with presumed cardiac etiology in Korea.

Detailed description: The Korean Cardiac Arrest Research Consortium (KoCARC) is a collaborative research network developed to comprehend various researches conducted in the field of out-of-cardiac arrest resuscitation and to strengthen the cooperative effort in conducting studies. It was organized in 2014 with recruitment of hospitals willing to participate voluntarily to the consortium.

Not only for emergency medicine, but KoCARC is expanding the research collaboration with cardiology, preventive medicine and epidemiology as well. To enhance the professionalism and effectiveness in research, seven research committees, which consists of Epidemiology and Preventive Research Committee (EPR), Community Resuscitation Research Committee (CRR), EMS Resuscitation Research Committee (ERR), Hospital Resuscitation Research Committee (HRR), Hypothermia and Post-resuscitation Care Research Committee (HPR), Cardiac Care Resuscitation Committee (CCR) and Pediatric Resuscitation Research Committee (PRR). Also Data Safety and Monitoring Board Committee (DSMB) is organized to provide annual review and Security and Ethics Committee to oversight security and ethical issues in research. Monthly meeting of interdisciplinary steering committee, consists of the consortium chair, steering committee chair, each research committee chair and secretary committee, is held to approve the proposed research agendas and to mediate between multi-center trial participating hospitals.

KoCARC registry is a data collecting system composed of OHCA risk and prognostic variables developed to provide the platform to researches conducted in KoCARC.

Eligibility criteria: Inclusion Criteria:

* OHCA patients who were transported to participating emergency department (ED) by emergency medical service with resuscitation efforts and whose arrest was identified as a presumed cardiac etiology by emergency physicians in ED.

Exclusion Criteria:

* OHCA with terminal illness documented by medical record, under hospice care, with pregnancy, with pre-documented 'Do Not Resuscitate' card
* OHCA of definite non-cardiac etiology, including trauma, drowning, poisoning, burn, asphyxia, or hanging

Primary outcomes:
measure: Survival at 6 month
timeFrame: 6 months after cardiac arrest
Secondary outcomes:
measure: Good neurological recovery at 6 month
timeFrame: 6 months after cardiac arrest
Other outcomes:
Locations:
city: Seoul
country: Korea, Republic of
facility: Korean Cardiac Arrest Resuscitation Consortium
Study officials:
affiliation: Korean Cardiac Arrest Resuscitation Consortium
name: Sung-Pil Chung, MD, PhD
role: STUDY_CHAIR
References:
citation: Jeong D, Lee GT, Park JE, Chang H, Kim T, Cha WC, Yoon H, Hwang SY, Shin TG, Sim MS, Jo I, Lee SH, Shin SD, Choi JH. Extracorporeal Life-support for Out-of-hospital Cardiac Arrest: A Nationwide Multicenter Study. Shock. 2022 May 1;57(5):680-686. doi: 10.1097/SHK.0000000000001924. Epub 2022 Mar 10.
citation: Kim SJ, Kim HS, Hwang SO, Jung WJ, Roh YI, Cha KC, Shin SD, Song KJ; Korean Cardiac Arrest Research Consortium (KoCARC) Investigators. Ionized calcium level at emergency department arrival is associated with return of spontaneous circulation in out-of-hospital cardiac arrest. PLoS One. 2020 Oct 12;15(10):e0240420. doi: 10.1371/journal.pone.0240420. eCollection 2020.
citation: Yoon JC, Kim YJ, Ahn S, Jin YH, Lee SW, Song KJ, Shin SD, Hwang SO, Kim WY; Korean Cardiac Arrest Research Consortium KoCARC. Factors for modifying the termination of resuscitation rule in out-of-hospital cardiac arrest. Am Heart J. 2019 Jul;213:73-80. doi: 10.1016/j.ahj.2019.04.003. Epub 2019 May 3.
citation: Lee DE, Lee MJ, Ahn JY, Ryoo HW, Park J, Kim WY, Shin SD, Hwang SO; Korean Cardiac Arrest Research Consortium (KoCARC). New Termination-of-Resuscitation Models and Prognostication in Out-of-Hospital Cardiac Arrest Using Electrocardiogram Rhythms Documented in the Field and the Emergency Department. J Korean Med Sci. 2019 May 6;34(17):e134. doi: 10.3346/jkms.2019.34.e134.