Clinical trial NCT04206436: CFTR Modulator Effects on Bone and Muscle in Adults With Cystic Fibrosis
Official title: CFTR Modulator Effects on Bone and Muscle in Adults With Cystic Fibrosis
Study type: OBSERVATIONAL
Overall status: ACTIVE_NOT_RECRUITING
Conditions: Cystic Fibrosis
Bone Loss
Muscle Loss
Lead sponsor: Indiana University
Sponsor class: OTHER
Collaborators: name: Cystic Fibrosis Foundation
First posted: 2019-12-20
Enrollment: 63
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: CASE_ONLY
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Enrollment will target groups that are frequency matched for age (decade), race, sex, pancreatic insufficiency and glucocorticoid usage (inhaled or systemic as both have skeletal effects in some studies) to control for these factors influencing relevant bone and muscle outcomes. (see statistical description). The study will enroll up to 30 subjects in each group, expecting up to 25% dropout.

Brief summary: Study is looking at the effects of cystic fibrosis treatment on bone muscle.

Detailed description: Cystic fibrosis (CF) is a complex multisystem genetic disease, with pulmonary and gastrointestinal consequences dominating the clinical picture. The life-expectancy of CF patients has increased through several therapeutic advances. Although respiratory failure remains the major cause of mortality in CF, musculoskeletal impairments contribute to major morbidity. In the general population, musculoskeletal conditions are among the most common reasons for seeking medical care, and the risk of osteoporotic fracture increases with age. As the CF population ages, the morbidity related to musculoskeletal effects may increase.

The etiology of CF related bone disease is multifactorial and includes effects of pancreatic insufficiency, poor nutritional status, vitamin D deficiency, glucocorticoid treatment, inflammation, hypogonadism, and sarcopenia, collectively resulting in attenuated bone mineral accrual and low bone density The effect of cystic fibrosis transmembrane conductance regulator (CFTR) modulating drugs on bone disease in CF has not been evaluated. Effects of CFTR modulators may help counter the bone and muscle consequences of CF either directly by effects on bone or muscle cells, or indirectly by improved lung disease, improved nutritional status, decreased systemic inflammation or glucocorticoid use, or subsequent increases in physical activity.

The rationale that underlies the proposed research is that better understanding of the bone and muscle effects of CFTR modulator therapies will help guide strategies to optimize bone accrual, prevent osteoporosis and fractures, and improve functional outcomes in the aging CF population. Set on the backbone of a longitudinal observational cohort study, the study will systematically and comprehensively evaluate changes in bone and muscle mass and strength from baseline to 12 month and 24 month time points among patients receiving CFTR modulator therapies and also among controls not receiving CFTR modulator therapies.

Eligibility criteria: Inclusion Criteria:

* documented, confirmed diagnosis of CF

  * Age ≥18 years old
  * \>21 days since the start of their last pulmonary exacerbation at the baseline visit
  * Provide signed written informed consent to participate

Exclusion Criteria:

* • Estimated glomerular filtration rate (eGFR) \<30 ml/min/m2 using the CKD-EPI equation,

  * Treatment with any osteoporosis medication within 6 months for oral agents or 1 year for intravenous or injectable agents (Subjects may participate if therapy stopped earlier than these time periods).
  * Current treatment with growth hormone or IGF-1
  * Currently pregnant or lactating or planning plan on becoming pregnant during the duration of the study.
  * Life expectancy less than 12 months
  * History of lung transplantation
  * Conditions that in the opinion of the investigators would interfere with the ability to collect or interpret the data, or put the patient at higher safety risk from study procedures.

Primary outcomes:
measure: Identify the effects of CFTR modulators on bone mineral density
timeFrame: 12 months
measure: establish the effect of CFTR modulators on sarcopenia.
timeFrame: 12 months
Secondary outcomes:
measure: Identify the effect of CFTR modulators on bone mineral density
timeFrame: 6, 12 and 24 month
measure: establish the effect of CFTR modulators on sarcopenia.
timeFrame: 6, 12 and 24 month
Other outcomes:
Locations:
city: Indianapolis
country: United States
facility: Indiana University
state: Indiana
Study officials:
affiliation: Indiana University
name: Erik A Imel, MD
role: PRINCIPAL_INVESTIGATOR
References: