Clinical trial NCT00673647: CANDIS-II: Evaluation of the Cognitive-behavioral Treatment Programme CANDIS
Official title: Evaluation of the Cognitive-behavioral Treatment Programme CANDIS in the German Outpatient Treatment Service System (CANDIS-II)
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: PHASE3
Conditions: Cannabis Use Disorders
Keywords: cannabis
dependence
marijuana
CBT
efficacy of CBT for cannabis use disorders
Lead sponsor: Technische Universität Dresden
Sponsor class: OTHER
Collaborators: name: Federal Ministry of Health
First posted: 2008-05-07
Enrollment: 450
Sex: ALL
Minimum age (years): 16
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: CROSSOVER
Primary purpose: TREATMENT

Brief summary: The purpose of this study is to evaluate the effectiveness of the cognitive-behavioral treatment program CANDIS among n=450 patients with cannabis use disorders in a mulicenter randomized-controlled clinical trial (n=11 outpatient treatment centers).


Eligibility criteria: Inclusion Criteria:

* motivation to change cannabis use
* age 16 or older
* current (12 mth) regular cannabis use (at least 2 days a week)
* informed consent to the study procedures and assessments

Exclusion Criteria:

* current alcohol or any illicit drug dependence syndrome according to DSM-IV other than due to cannabis
* lifetime history of any psychotic disorder
* current severe episode of Major depression
* current panic-agoraphobic disorder (severe)
* severe learning disability, brain damage or pervasive developmental disorder
* currently acute suicidality
* not fluent in german language
* any other current treatment for cannabis use disorders

Primary outcomes:
measure: abstinence, defined as no evidence of cannabis use during the past 4 weeks as evidenced by self report and a negative urine screen; number of times a cannabis product was used in the past 4 weeks; retention rate
timeFrame: at the end of treatment
Secondary outcomes:
Other outcomes:
Locations:
city: Bautzen
country: Germany
facility: Psychosoziale Beratungs- und Behandlungsstelle für Suchtgefährdete und -kranke
city: Berlin
country: Germany
facility: LogIn Jugend- und Suchtberatung
city: Berlin
country: Germany
facility: Therapieladen e.V.
city: Braunschweig
country: Germany
facility: Jugend- und Drogenberatung Braunschweig
city: Dresden
country: Germany
facility: Jugend- und Drogenberatung Dresden
city: Hamburg
country: Germany
facility: Die Boje - Suchtberatung und Behandlung
city: Hannover
country: Germany
facility: Drobs Hannover
city: Muenchen
country: Germany
facility: Caritas-Fachambulanz für junge Suchtkranke
city: Muenster
country: Germany
facility: Suchtambulanz der LWL-Klinik Münster
city: Osnabrueck
country: Germany
facility: Caritas Fachambulanz für Suchtprävention und Rehabilitation Osnabrück
city: Stuttgart
country: Germany
facility: Release Stuttgart e.V. & Ambulante Beratungs- und Behandlungsstelle Klinikum Stuttgart
Study officials:
affiliation: Technische Universitaet Dresden
name: Hans-Ulrich Wittchen, PhD
role: STUDY_DIRECTOR
affiliation: Technische Universitaet Dresden
name: Gerhard Buehringer, PhD
role: STUDY_DIRECTOR
affiliation: Technische Universitaet Dresden
name: Eva Hoch, PhD
role: PRINCIPAL_INVESTIGATOR
References:
citation: Hoch E, Buhringer G, Pixa A, Dittmer K, Henker J, Seifert A, Wittchen HU. CANDIS treatment program for cannabis use disorders: findings from a randomized multi-site translational trial. Drug Alcohol Depend. 2014 Jan 1;134:185-193. doi: 10.1016/j.drugalcdep.2013.09.028. Epub 2013 Oct 8.