Clinical trial NCT03285347: Effect of Computer-based Cognitive Training on Attention and Executive Functions in Patients With Parkinson's Disease
Official title: The Effect of Computer-based Cognitive Training on Attention and Executive Functions in Patients With Parkinson's Disease
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Parkinson Disease
Executive Dysfunction
Keywords: parkinson
executive dysfunction
attention
computer-based cognitive training
Lead sponsor: Bispebjerg Hospital
Sponsor class: OTHER
First posted: 2017-09-18
Enrollment: 30
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Intervention model description: Two intervention Groups training with each their computer-based cognitive programme, one control Group receiving no intervention except for the same amount of follow-ups as the two intervention Groups.
Primary purpose: HEALTH_SERVICES_RESEARCH

Brief summary: The current study adresses the effect of two different computer-based cognitive trianing programmes on attention and executive functions in patients with Parkinson's disease.

Detailed description: The current study adresses the effect of two different computer-based cognitive training programmes (Brain+ Evolution and Scientific Brain Training PRO) on attention and executive functions in patients with Parkinson's disease. The patients are assigned to one of three groups. Two training groups with each their programme, and a control Group. The training groups will train at home for 8 weeks with follow-ups every second week. The control group will not train at home, but will also receive a follow-up with computer-based stimuli (computerized Card game) every second week, to minimize the possibility that a possible effect is due to the follow-up's with a professional, and not due to the computer training at home.

Eligibility criteria: Inclusion Criteria:

* Patients with Parkinson's disease AND
* Montreal cognitive assesment (MOCA)-score between 22-28
* Motorically cabable of using an iPad
* Not receiving antipsychotic medicine
* No comorbid diseases which might influence the level of executive functioning, for an example ADHD or acquired brain damage

Exclusion Criteria:

* People without Parkinson's disease
* Parkinson's patients not included in the above inclusion criteria

Primary outcomes:
measure: SDMT
timeFrame: 2 minutes
measure: PDQ-39
timeFrame: 20 minutes
Secondary outcomes:
measure: HADS
timeFrame: 10 minutes
measure: Digit span
timeFrame: 10 minutes
measure: Verbal fluency
timeFrame: 3 minutes
measure: Stroop colour/word test
timeFrame: 3 minutes
measure: Trail Making A and B
timeFrame: 5 minutes
Other outcomes:
Locations:
city: Copenhagen
country: Denmark
facility: Bispebjerg Hospital
state: Region Hovedstaden
Study officials:
affiliation: Doctor
name: Annemette Løkkegaard, Ph.d.
role: STUDY_DIRECTOR
References:
citation: Svaerke K, Faerk AK, Riis A, Stiegnitz von Ehrenfels SEM, Mogensen J, Lokkegaard A. Effects of Computer-Based Cognitive Rehabilitation on Attention, Executive Functions, and Quality of Life in Patients with Parkinson's Disease: A Randomized, Controlled, Single-Blinded Pilot Study. Dement Geriatr Cogn Disord. 2021;50(6):519-528. doi: 10.1159/000520591. Epub 2022 Jan 5.