louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT06874218: Digital Analysis of Primary Teeth Crown Dimensions and Clinical Evaluation in a Sample of Egyptian Children
Official title: Digital Analysis of Primary Teeth Crown Dimensions and Clinical Evaluation in a Sample of Egyptian Children
Study type: INTERVENTIONAL
Overall status: NOT_YET_RECRUITING
Phase: NA
Conditions: Primary Teeth Crown Dimensions in a Sample of Egyptian Children
Keywords: Teeth Dimensions
Digital Analysis
Egyptian Children
Lead sponsor: Tanta University
Sponsor class: OTHER
First posted: 2025-03-13
Enrollment: 59
Sex: ALL
Minimum age (years): 4
Maximum age (years): 6
Standard ages: CHILD
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Intervention model description: Digitally determine crown dimensions of primary teeth in a sample of Egyptian children.
Primary purpose: SCREENING

Brief summary: The aim of this study will be conducted to:

1. Digitally determine crown dimensions of primary teeth in a sample of Egyptian children.
2. Clinical evaluation of prefabricated zirconia crowns according to the Egyptian sizes compared with the international standard zirconia crowns sizes for primary upper central incisors

Detailed description: Currently, there is limited availability of primary tooth crown measurement for Egyptian children. SO, this study aims to digitally determine tooth crown dimensions of primary teeth in a group of Egyptian children and compare prefabricated zirconia crowns according to the Egyptian crown sizes with the international standard zirconia crowns sizes for primary upper central incisors.

Eligibility criteria: Inclusion Criteria:

* Children having normal fully erupted primary teeth and with no morphological variations.
* Children with no history of orthodontic or prosthodontic treatment.
* Children with normal overjet and overbite.
* Sound interproximal \& buccal / lingual walls with or without minimal occlusal pits \& fissure incipient caries.
* No previous interproximal \& buccal / lingual restorations.
* Intact mesial and distal marginal ridge.

Exclusion Criteria:

* Children with gross carious lesions.
* Children with hypo-mineralization, hypoplasia and fracture primary teeth.
* Children with medical disabilities

Primary outcomes:
measure: crown dimensions of primary teeth in a sample of Egyptian children.
timeFrame: intra operative
Secondary outcomes:
measure: Clinical evaluation of prefabricated zirconia crowns according to the Egyptian sizes compared with the international standard zirconia crowns sizes for primary upper central incisors.
timeFrame: intra operative
Other outcomes:
Locations:
city: Tanta
country: Egypt
facility: Tanta university
Study officials:
affiliation: Tanta University
name: Reham Abdelwahed Melegy, MSC
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT05821218: Evaluation of the Sacroiliac Joints of People With Chronic Low Back Pain From a Chiropractic Perspective
Official title: Evaluation of the Sacroiliac Joints of People With Chronic Low Back Pain From a Chiropractic Perspective
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Back Pain
Keywords: sacroiliac
Lead sponsor: Bahçeşehir University
Sponsor class: OTHER
First posted: 2023-04-20
Enrollment: 80
Sex: ALL
Minimum age (years): 18
Maximum age (years): 65
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: OTHER
Time perspective: OTHER
Sampling method: PROBABILITY_SAMPLE
Study population: Bahçeşehir University

Brief summary: Low back pain is a musculoskeletal problem that we commonly encounter in the clinic,which negatively affects the quality of life, reduces productivity and limits the ability to perform activities of daily living.

Detailed description: The most common causes of low back pain are disc lesions and soft tissue injuries due to trauma, rheumatological disorders such as spondylosis, spinal stenosis and spondylolisthesis, ankylosing spondylitis and rheumatoid arthritis due to degenerative changes; osteoporosis, root disorders, and sacroiliac joint dysfunction

Eligibility criteria: Inclusion criteria;

* Volunteer
* Not undergoing surgery related to the lumbar region
* Cases without lumbar steroid injection in the last 3 months
* Not having visual and hearing loss
* Having low back pain
* Cases without neurological problems
* Cases without tumor and infection in the lumbar region
* Cases in which communication and cooperation are provided Exclusion criteria;
* Not having a musculoskeletal or neuromuscular disease that limits mobility,
* No upper extremity sequelae,
* Not volunteering

Primary outcomes:
measure: Leg Check Test
timeFrame: 1 day
measure: Pressure Pain Threshold Measurement with Algometer
timeFrame: 1 day
measure: Oswestry Disability Index
timeFrame: one day
measure: Patrick FABER Test:
timeFrame: 1 day
measure: Gaenslen Test
timeFrame: 1 day
measure: Compression Test
timeFrame: 1 day
measure: The straight leg raise test
timeFrame: 1 day
Secondary outcomes:
Other outcomes:
Locations:
city: Istanbul
country: Turkey
facility: HAZAL genç
state: None Selected
Study officials:
References:
Clinical trial NCT05244018: Outcome of High Dose Vitamin D on Prognosis of Sepsis Requiring Mechanical Ventilation
Official title: Outcome of High Dose Vitamin D on Prognosis of Sepsis Requiring Mechanical Ventilation; A Randomized Controlled Trial
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE4
Conditions: Sepsis
Lead sponsor: Ain Shams University
Sponsor class: OTHER
First posted: 2022-02-17
Enrollment: 80
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: There is a high prevalence of vitamin D deficiency in the critically ill patient population, with approximately 60% of patients found to be vitamin D deficient, (25(OH)D concentrations \<20 ng/mL) and an additional 30% of patients being vitamin D insufficient, (25(OH)D = 20-30 ng/mL).Approximately 80% of sepsis/septic shock patients experience respiratory failure and require mechanical ventilation. Furthermore, several studies document that vitamin D deficiency could be associated with poor outcomes in critically ill patient.


Eligibility criteria: Inclusion Criteria:

* Diagnosed with sepsis and required mechanical ventilation (MV) within 24 hours from ICU admission.
* Expected to require mechanical ventilation for at least 72 hours after study entry.

Exclusion Criteria:

* Age \<18 years.
* inability to obtain informed consent from the patient and/or legally authorized representative.
* BMI\> 40.
* Pregnant or breastfeeding.
* Chronic kidney diseases
* Pancreatitis.
* Hepatic insufficiency
* Cases with coagulopathy
* Moribund and not expected to survive 96 hours.
* Ongoing shock
* History of therapy with high dose vitamin D3 within previous 6 months.
* History of disorders associated with hypercalcemia
* Cancer as the cause of sepsis.
* Subjects undergoing chemotherapy.
* Immune compromised patients.
* Pneumonia developed \< 48 hours following intubation.
* Patients with history of aspiration before intubation.
* known allergy to vitamin D.

Primary outcomes:
measure: Change in procalcitonin level (ng/ml) and antimicrobial peptide cathelicidin (LL37) (ng/ml) level at day 7.
timeFrame: 7 days
Secondary outcomes:
Other outcomes:
Locations:
city: Cairo
country: Egypt
facility: Ain-Shams University Hospitals
Study officials:
References:
Clinical trial NCT04348318: Advance Directive Implementation and Scientific Evaluation Study
Official title: Advance Directive Implementation and Scientific Evaluation (ADVISE) Study
Study type: OBSERVATIONAL
Overall status: RECRUITING
Conditions: Loss of Capability of Judgement
Keywords: advance directives
life-sustaining treatment
neurocritical illness
Lead sponsor: University Hospital, Basel, Switzerland
Sponsor class: OTHER
First posted: 2020-04-16
Enrollment: 2000
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: RETROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: The study population will include all consecutive adult patients (i.e., ≥18 years of age) treated in the intensive care unit at the University Hospital Basel from 2011 to 2023.

Brief summary: This study is to better understand the use of advance directives, their implementation in the intensive care unit, and their effects on outcome. Data from the digital medical records of all consecutive adult patients admitted to the intensive care unit at the University Hospital Basel from 2011 to 2023 are retrospectively extracted. Descriptive analyses will be applied to report the proportion of patients with an advance directive. In-hospital outcome (defined as survival, Glasgow Outcome Score, and return of neurologic function to premorbid baseline) will be compared between patients with and without advanced directives


Eligibility criteria: Inclusion Criteria:

* adult patients treated for more than 48 hours in the intensive care unit (post-operative or internal medicine) of the University Hospital Basel in the years 2011-2023

Exclusion Criteria:

* Patients with documented refusal of the general consent.
* Patients who have been treated in the intensive care unit for less than 48 hours

Primary outcomes:
measure: proportion of patients without predefined health care agents and/or completed advance directives
timeFrame: at baseline
measure: number of adequate translations of directives into clinical practice
timeFrame: at baseline
Secondary outcomes:
measure: In-hospital outcome (defined as survival and return of neurologic function to premorbid baseline)
timeFrame: at baseline
measure: In-hospital outcome (defined as Glasgow Outcome Score)
timeFrame: at baseline
Other outcomes:
Locations:
city: Aarau
country: Switzerland
facility: Kantonsspital Aarau
city: Basel
country: Switzerland
facility: Clinic for Intensive Care Medicine, University Hospital Basel
Study officials:
affiliation: Clinic for Intensive Care Medicine, University Hospital Basel
name: Raoul Sutter, PD Dr. med
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT05298618: Magnesium Administration After Cardioplegic Arrest With Del Nido Cardioplegia
Official title: Magnesium Administration After Cardioplegic Arrest With Del Nido Cardioplegia
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Del Nido Cardioplegia
Lead sponsor: Children's Hospital Medical Center, Cincinnati
Sponsor class: OTHER
First posted: 2022-03-28
Enrollment: 152
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Observational model: CASE_ONLY
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: All patients undergoing CPB with dNC cardioplegic arrest.

Brief summary: The cardioplegia solution of choice in many pediatric cardiac congenital programs is the del Nido solution. While many cardioplegia solutions provide diastolic arrest, del Nido provides a longer period of time between doses of cardioplegia. Many of the other cardioplegia solutions do not incorporate magnesium into the constituents, but del Nido does. Routine practice at CCHMC is to dose 25 mg/kg magnesium upon removal of the heart cross-clamp to protect against hypomagnesemia and associated arrhythmias. However, with the incorporation of magnesium in the del Nido solution, it may not be necessary to administer magnesium post cross-clamp and it could in fact be detrimental if the magnesium level is too high. This observational study will examine the magnesium levels prior to and after cross-clamp removal under our current process. The magnesium levels measured after the administration of del Nido cardioplegia and prior to cross-clamp removal will help inform our current practice.


Eligibility criteria: Inclusion Criteria:

* Patients undergoing cardiac surgery requiring CPB and cardioplegic arrest with del Nido cardioplegia solution.
* Patients planned to receive post cross-clamp dose of 25 mg/kg magnesium sulfate.

Primary outcomes:
measure: Examine magnesium levels prior to and after cross-clamp.
timeFrame: 24 months from start of enrollment.
Secondary outcomes:
Other outcomes:
Locations:
city: Cincinnati
country: United States
facility: Cincinnati Children's Hospital
state: Ohio
Study officials:
affiliation: Children's Hospital Medical Center, Cincinnati
name: James Reagor
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT01614418: Radiofrequency Ablation for Gastric Metaplasia and Dysplasia
Official title: Endoscopic Radiofrequency Ablation for Gastric Metaplasia and Dysplasia
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE1
PHASE2
Conditions: Gastric Dysplasia
Intestinal Metaplasia
Lead sponsor: The University of Hong Kong
Sponsor class: OTHER
First posted: 2012-06-08
Enrollment: 10
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NON_RANDOMIZED
Intervention model: SINGLE_GROUP
Primary purpose: TREATMENT

Brief summary: Gastric intestinal metaplasia (IM) and dysplasia, also referred to as intra-epithelial neoplasia, are well recognized precursors of gastric cancer. Apart from endoscopic surveillance, there is no other intervention which predictably eradicates pre-cancerous gastric lesions.

Endoscopic radiofrequency ablative (RFA) therapy has been recently shown to be highly effective in eradicating both IM and dysplasia in patients with Barrett's esophagus. However, the potential role of RFA to remove gastric IM and dysplasia remains unknown. In this study, we determine the feasibility of using endoscopic RFA in treating early gastric neoplasia (metaplasia and dysplasia). Patients with gastric metaplasia and/or dysplasia will be treated with endoscopic RFA. The safety and effects of RFA will be determined.


Eligibility criteria: Inclusion Criteria:

1. Histological confirmation of gastric IM or dysplasia.
2. The lesion is no larger than 5 cm in diameter.
3. Age ≥ 18 years.
4. No previous endoscopic mucosal resection or submucosal dissection.
5. No active H. pylori infection.
6. Subject is able to tolerate endoscopy and sedation.
7. Subject agrees to participate, fully understands content of the informed consent, and signs the informed consent form.

Exclusion Criteria:

1. Gastric cancer (intra-mucosal cancer or worse).
2. Prior gastric irradiation or surgery.
3. Anti-platelet or anti-thrombotic medication use that cannot be stopped for 7 days before and after RFA.
4. Gastric ulcers, fistulae and varices.
5. History of alcohol and/or controlled substance dependency.
6. Pregnancy.

Primary outcomes:
measure: Histological clearance of dysplasia/metaplasia
timeFrame: 6 month
Secondary outcomes:
measure: Number of Participants with Adverse Events
timeFrame: up to 6 month
Other outcomes:
Locations:
city: Hong Kong
country: Hong Kong
facility: University of Hong Kong
Study officials:
affiliation: The University of Hong Kong
name: Wai Keung Leung, MD
role: PRINCIPAL_INVESTIGATOR
References:
citation: Leung WK, Tong DK, Leung SY, Chan FS, Tong TS, Ho RS, Chu KM, Law SY. Treatment of Gastric Metaplasia or Dysplasia by Endoscopic Radiofrequency Ablation: A Pilot Study. Hepatogastroenterology. 2015 May;62(139):748-51.
Clinical trial NCT01649518: A Measurement of Knee Osteoarthritis Usual Care
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Osteoarthritis, Knee
Guideline Adherence
Quality Indicators, Health Care
Lead sponsor: Universitaire Ziekenhuizen KU Leuven
Sponsor class: OTHER
First posted: 2012-07-25
Enrollment: 284
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Time perspective: RETROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: General Practice: Based on the electronic patient files of general practiotioners of the MEDIDOC users-group (an electronic software package) a list will be generated of patients diagnosed with knee osteoarthritis. A random sample of these patients will be addressed to take part into the study by a questionnaire.

Orthopedic Surgery: Patients, consulting orthopedic surgeons for knee osteoarthritis will receive a patient questionnaire.

Physiotherapy: Patients, recruited by general practitioners and orthopedic surgeons will be asked about the care they received by their physiotherapist. Moreover physiotherapists will be recruited by the national association of physiotherapists to complete a questionnaire about the care they usually deliver.

Brief summary: Osteoarthritis is the most common affection of joints worldwide. Multiple international guidelines on the approach and treatment of knee osteoarthritis are available. Nevertheless there seems to be a gap between usual care and the preferred one.

A vigorous set of evidence-based quality indicators on osteoarthritis diagnosis and therapy was developed by a multidisciplinary expert team. This project aims to map usual care and to explore the gaps between usual care and international guidelines in a second stage. This will enable us to develop a tightly targeted quality improvement intervention later on.


Eligibility criteria: Inclusion Criteria:

* Diagnosis of knee osteoarthritis

Exclusion Criteria:

* Knee replacement surgery
* Acute trauma (recruitment by orthopedic surgeons)

Primary outcomes:
measure: Guideline adherence measured by a number of quality indicators and presented as the percentage of patients in whom a quality indicator was reached
timeFrame: one measurement at the point of recruitment
Secondary outcomes:
measure: Barriers and facilitators for guideline adherence
timeFrame: 10 years
Other outcomes:
Locations:
city: Leuven
country: Belgium
facility: KU Leuven
Study officials:
References:
Clinical trial NCT04977518: Characteristics of Infective Endocarditis in East China
Official title: Study of the Clinical Presentations, Treatment and Outcomes of Infective Endocarditis Patients in a Tertiary Hospital in East China
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Infective Endocarditis
Lead sponsor: Second Affiliated Hospital, School of Medicine, Zhejiang University
Sponsor class: OTHER
First posted: 2021-07-27
Enrollment: 183
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: RETROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Patients with a clinical diagnosis of infective endocarditis between January 2008 and December 2015 in a tertiary hospital located in the East China

Brief summary: This was a retrospective observational study of consecutive cases of definite or possible infective endocarditis (IE) as per the modified Duke criteria between January 2008 and December 2015, which was performed at the Second Affiliated Hospital of Zhejiang University, School of medicine (SAHZU), a tertiary care referral hospital located in East China.

Detailed description: Infective endocarditis (IE) is a rare but life-threatening serious disease that still has a high mortality, even in developed countries. The objective of this study was to evaluate the clinical presentations, treatment and outcomes of IE patients in a tertiary hospital in East China over an 8-year period. This was a retrospective observational study of consecutive cases of definite or possible IE as per the modified Duke criteria between January 2008 and December 2015.

Eligibility criteria: Inclusion Criteria:

* Patients with a clinical diagnosis of infective endocarditis.

Exclusion Criteria:

* Patients did not meet the modified Duke criteria.

Primary outcomes:
measure: Complications (neurological events, systemic embolism, and congestive heart failure) of infective endocarditis
timeFrame: During the hospitalization, average of 1 months
measure: Mortality
timeFrame: During the hospitalization, average of 1 months
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
affiliation: 2nd Affiliated Hospital, School of Medicine, Zhejiang University, China
name: Huimin Xu
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT05117918: Overactive Bladder Telemedicine Non-inferiority Trial
Official title: A Prospective Study Evaluating the Feasibility of Telemedicine Use in the Overactive Bladder Clinical Care Pathway: a Non-inferiority Study Assessing Patient Satisfaction and Progression to Third Line Overactive Bladder Therapies
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Overactive Bladder
Lead sponsor: University of California, Los Angeles
Sponsor class: OTHER
First posted: 2021-11-11
Enrollment: 177
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: OTHER

Brief summary: In this study, the investigators aim to validate the telemedicine paradigm as a feasible alternative to traditional in-person clinic visits for the management of overactive bladder (OAB).

Detailed description: This is a single-center, prospective randomized controlled trial. The study population will consist of two primary cohorts stratified based on the method of follow-up, either traditional in-person clinic visit or telemedicine appointment. The primary outcome will be satisfaction with OAB treatment. Secondary endpoints include rate of progression to third line therapies, changes in OAB symptom scores, safety, and cost. This non-inferiority trial is designed to provide an alternative option for care delivery that may result in improved patient satisfaction and compliance, and decreased cost, time, and travel burden for patients.

Eligibility criteria: Inclusion Criteria:

* Idiopathic overactive bladder diagnosis, both OAB wet and OAB dry

Exclusion Criteria:

* Active Urinary Tract Infection (UTI)
* Stage 3 or 4 prolapse
* Underlying neurologic condition contributing to OAB
* Use of catheter

Primary outcomes:
measure: Patient Satisfaction
timeFrame: 1 year
Secondary outcomes:
measure: PGII
timeFrame: 1 year
measure: Incidence of Treatment-emergent adverse events (safety and tolerability)
timeFrame: 1 year
measure: Accumulated cost of visit to patient (Cost)
timeFrame: 1 year
measure: Accumulated time of visit for patient (Time)
timeFrame: 1 year
measure: Overactive Bladder Symptoms
timeFrame: 1 year
Other outcomes:
Locations:
city: Los Angeles
country: United States
facility: UCLA
state: California
Study officials:
References:
Clinical trial NCT03751813: Baby Bump Lifestyle Intervention Supplement Study
Official title: Baby Bump Lifestyle Intervention Supplement Study
Study type: INTERVENTIONAL
Overall status: TERMINATED
Phase: NA
Conditions: Gestational Diabetes
Lead sponsor: State University of New York at Buffalo
Sponsor class: OTHER
First posted: 2018-11-23
Enrollment: 4
Sex: FEMALE
Minimum age (years): 18
Maximum age (years): 40
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The overall purpose of this study is to examine how natural supplements can mediate the effects of stress on fetal development during pregnancy.


Eligibility criteria: Inclusion Criteria:

* Pregnant woman presenting to her first obstetrical visit for this pregnancy
* Must be in the first trimester (\<13 weeks)
* 18 years or older
* High-stress levels as measured by the Perceived Stress Level Questionnaire
* Must be a single pregnancy (e.g. not twins, triplets, etc.)

Exclusion Criteria:

* Diabetes (types 1 and 2)
* Diagnosis of gestational diabetes in prior pregnancy
* Hyperemesis gravidarum or severe morning sickness that interferes with supplement intake
* Major medical illnesses including but not limited to: malabsorption syndromes (Celiac's disease, Crohn's, Ulcerative Colitis), Systemic Lupus Erythematosus and other major autoimmune conditions

Primary outcomes:
measure: lower blood stress markers via venous draw
timeFrame: 9 months
Secondary outcomes:
Other outcomes:
Locations:
city: Buffalo
country: United States
facility: SUNY Buffalo
state: New York
Study officials:
References: