louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT06528899: Physiotherapy in Emergency Department: a Service Analysis From a French Hospital
Official title: Physiotherapy in Emergency Department: a Service Analysis From a French Hospital
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Fall Patients
Pain
Sprains
Respiratory Insufficiency
Vertigo
Illness Behavior
Keywords: physical therapy
patient pathway
patient care management
Lead sponsor: Université de Nantes
Sponsor class: OTHER
First posted: 2024-07-30
Enrollment: 461
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: RETROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: All adult patients visiting the Emergency Department

Brief summary: The skills of physiotherapists have been employed to enhance access to optimal care in Emergency Departments (ED). No study has yet been conducted on the practices in France. The primary objective of this study was to describe the French practices of physiotherapy within an ED, and to secondary examine the effect on patient discharge.

Detailed description: A retrospective observational study was conducted on patients who received a referral for physiotherapy in the ED (E-PT) of the Universitarian Hospital of Nantes during a six-month observation period in 2022. A total of 461 medical records were extracted, including patient characteristics and the main chief complaint at the time of admission. Details on the delivery of E-PT were collected, as well as the end status at the exit of the ED. Descriptive statistics were performed to analyse the data. A propensity score analysis examined the association between the patients' status at the exit of the ED and E-PT.

Eligibility criteria: Inclusion Criteria:

* admission in the Emergency Departement
* aged over 18
* refferal for physiotherapy within the Emergency Department

Exclusion Criteria:

* death
* no admission within the Emergency Department (only administrative purposes)

Primary outcomes:
measure: Discharge at the exit of ED
timeFrame: up to 7 days (date of exit)
Secondary outcomes:
measure: Length of stay
timeFrame: up to 7 days (date of exit)
Other outcomes:
measure: Age
timeFrame: date of presenting to ED
measure: Day of admission
timeFrame: date of presenting to ED
measure: Chief complaint
timeFrame: date of presenting to ED
measure: Gender
timeFrame: date of presenting to ED
measure: Unit of referral
timeFrame: date of presenting to ED
Locations:
city: Nantes
country: France
facility: CHU de Nantes
city: Nantes
country: France
facility: Université de Nantes - MIP UR 4334 (Motricity, Movement, Interactions)
Study officials:
affiliation: guillaume.le-sant@univ-nantes.fr
name: Guillaume Le Sant, PhD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT06019299: Cluster-randomized Controlled Trial of Mindfulness-Based Cognitive Therapy Effects on Anxiety and Stress
Official title: Cluster-randomized Controlled Trial Examining the Effectiveness of Mindfulness-Based Cognitive Therapy for Anxiety and Stress Reduction Within College Students
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Anxiety
Stress
Keywords: Mindfulness-Based Cognitive Therapy
Lead sponsor: Michigan State University
Sponsor class: OTHER
First posted: 2023-08-31
Enrollment: 289
Sex: ALL
Minimum age (years): 17
Maximum age (years): 42
Standard ages: CHILD
ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Intervention model description: Cluster randomized allocation to Mindfulness-Based Cognitive Therapy intervention or positive control intervention.
Primary purpose: TREATMENT

Brief summary: To understand the potential effectiveness of a 4 week Mindfulness-Based Cognitive Therapy intervention delivered using a smartphone application for reducing anxiety and stress within college students.

Detailed description: The objective of this project is to understand the potential effectiveness of a 4 week Mindfulness-Based Cognitive Therapy intervention delivered using a smartphone application for reducing anxiety and stress within college students. Although in-person mindfulness-based cognitive therapy approaches have been found effective for reducing anxiety and stress; given the pervasiveness of anxiety and stress in this population, there is a need to provide alternative and accessible interventions to improve students' mental health. One such approach may be by leveraging existing tools such Sanvello - a free mindfulness-based cognitive therapy smartphone application - which could more easily be deployed across a broader population. Accordingly, using a cluster-randomized controlled design, this intervention will assess the extent to which 4-weeks of using the Sanvello application was effective for reducing anxiety and stress within college students.

Eligibility criteria: Inclusion Criteria:

* Enrolled in course

Exclusion Criteria:

* Complete inattendance in course during the pretest and study period.
* Opted out of data being available for research use

Primary outcomes:
measure: State-Trait Anxiety Inventory
timeFrame: Change from baseline, 4 weeks.
measure: Perceived Stress Scale
timeFrame: Change from baseline, 4 weeks.
Secondary outcomes:
Other outcomes:
Locations:
city: East Lansing
country: United States
facility: Department of Kinesiology
state: Michigan
Study officials:
affiliation: Michigan State University
name: Matthew B Pontifex, PhD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT01354899: A Open Study to Evaluate the Performance of Dressing on Subject With High Risk of Skin Breakdown
Official title: A Multi-Centre, Post CE Mark, Open Study to Evaluate the Performance of Thin Self-adherent Dressing Coated With a Soft Silicone Layer on Subjects With a High Risk of Skin Breakdown
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Critical Illness
Lead sponsor: Molnlycke Health Care AB
Sponsor class: INDUSTRY
First posted: 2011-05-17
Enrollment: 24
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: CASE_CONTROL
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: Critically ill patients at ICU.

Brief summary: The rational for the study is to add a thin self-adherent dressing on critically ill patients. Evaluate if the dressing might protect the skin for further breakdown.Participants will be followed for the duration of hospital stay, an expected average of 5 days.


Eligibility criteria: Inclusion Criteria:

* Provision of written informed consent
* Braden total score ≤ 12 at enrolment
* Male or female, ≥ 18 at enrolment
* No skin- breakdown
* Subject or family member is able to understand and comply with the requirements of the study, judged by the investigator

Exclusion Criteria:

* Risk area dosen´t fit the dressing size
* Documented skin disease
* Kown allergy to any of the components in the dressing
* Previous enroled in present study
* Subject included in other ongoing clinical investigation

Primary outcomes:
measure: Erythema (No/Yes)
timeFrame: During 5 days
Secondary outcomes:
measure: Overall Experience of Use of the Dressing
timeFrame: During 5 days
Other outcomes:
Locations:
city: Gothenburg
country: Sweden
facility: Dermatology Department
Study officials:
affiliation: Dermatology Department Sahlgrenska University Gothenburg
name: Jan Faergemann, Professor
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT05469399: Admission of the Patient to the Clinic After Surgery
Official title: The Effect of Game-Based Virtual Reality Learning Method on the Learning Outcomes of Nursing Students for Postoperative Admission of the Patient to the Clinic
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Post Operative Pain
Post-Op Hemorrhage
Postoperative Hypothermia
Nurse's Role
Keywords: post operative pain
post operative hemorrhage
nursing care
Lead sponsor: Gazi University
Sponsor class: OTHER
First posted: 2022-07-21
Enrollment: 82
Sex: ALL
Minimum age (years): 18
Maximum age (years): 30
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: SUPPORTIVE_CARE

Brief summary: Aim:This research was designed as a randomized controlled study to examine the effect of the game-based virtual reality learning method on the patient's post-operative admission to the clinic on the learning outcomes of the students.

Desing: This study was designed as a randomized controlled study to examine the effect of the game-based virtual reality learning method on the patient's post-operative admission to the clinic on the learning outcomes of the students.

Metod: The universe of the research will be nursing students who have taken the Surgical Diseases Nursing Course at Gazi University Faculty of Health Sciences Nursing Department in the 2021-2022 academic year. As a result of the power analysis using the G-power 3.1.9.7 package program; The effect size was calculated as 0.40 (It was seen from the literature studies that the effect size of the change in the knowledge score of the two groups was large effect size), and the total number of 68 samples is sufficient with 90% power, 5% margin of error, 95% confidence level, 20% drop-out Considering the rate of study, it was found sufficient to work with at least 82 people (Experiment: 41, Control: 41). For research data, "descriptive features form", "knowledge test form", "skill evaluation checklist", "student opinions form about game-based virtual reality game application", egameflow scale will be used.


Eligibility criteria: Inclusion Criteria:

* Students who voluntarily participated in the study
* Students who have taken all the subjects of the Surgical Diseases Nursing Course
* Students with smartphones, tablets, computers
* Students with internet access

Exclusion Criteria:

* Students who do not participate in the theoretical training
* Students who take the Surgical Diseases Nursing Course from below
* Students who do not want to continue the research
* Students who do not fill out the data collection forms at any stage
* Students who do not participate in the virtual reality-based game application
* Students who do not participate in any of the skills assessment
* Students who fill in the data collection forms incompletely

Primary outcomes:
measure: skills assessment
timeFrame: change in skill assessment for one week
measure: knowledge level
timeFrame: change in skill assessment for one week
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
References:
Clinical trial NCT02127099: The Incidence of Undiagnosed OSA Compared in Multi-ethic Races of Malaysia & the Associated Postoperative Complications
Official title: The Incidence of Undiagnosed OSA in Multi-ethic Races of Malaysia and the Associated Postoperative Complications
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Obstructive Sleep Apnea
Keywords: OSA
obstructive
sleep
apnea
operation
Lead sponsor: University of Malaya
Sponsor class: OTHER
First posted: 2014-04-30
Enrollment: 1000
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: All patients over age 18 undergoing non-cardiac surgery

Brief summary: Obstructive sleep apnoea (OSA) is a condition in which a person's sleep is disrupted with momentary periods of apnoea and hypopnoea. This occurs when there is a blockage to airflow. When this happens, the patient will snore, gasp or choke in the attempt to attain more oxygen. This results in disrupted sleep and the patient may even awake from sleep.

It has been found that a great proportion of Malaysians have habitual snoring and with the increase in obesity over the years, it is a concern that OSA may be prevalent in Malaysia.

However, it has been seen that OSA is commonly undiagnosed in patient. This poses a worry because these people can come in for surgery. Diagnosis of OSA before surgery is important in order to prepare for the complication related to OSA.

Detailed description: Research staff will interview and examine patients and review their charts to obtain information on patient characteristics. Patients will also be assessed using STOP-BANG Questionnaire \& Epworth Sleepiness Scale.

Anaesthesia and surgery will be performed according to routine standard of care.

Drugs used during anaesthesia, postoperative analgesia and hemodynamic data will be recorded.

During their stay in hospital, patients will be followed daily, and outcomes will be recorded, until discharge. Data on medications will be recorded.

Eligibility criteria: Inclusion Criteria:

* adult males and females
* age ≥ 18 years
* undergoing elective surgery ( general,regional or local anaesthesia with monitored anaesthesia care)

Exclusion Criteria:

* previous diagnosis of OSA or any sleep-related breathing disorder
* they are unwilling
* their surgery included tonsillectomy, septoplasty, uvloplasty, pharyngoplasty, tracheostomy, or prolonged mechanical ventilation

Primary outcomes:
measure: Incidence of OSA
timeFrame: 30 days
Secondary outcomes:
measure: Post-operative complications
timeFrame: 30 days
Other outcomes:
Locations:
city: Kuala Lumpur
country: Malaysia
facility: University Malaya Medical Centre
state: Wilayah Persekutuan
Study officials:
affiliation: University of Malaya
name: Chew Yin Wang, MBChB
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT04126499: Study to Characterise Patients Receiving Benralizumab in the Framework of an Individualized Access Program in Spain
Official title: Observational Retrospective Study to Characterise Patients Receiving Benralizumab in the Framework of an Individualized Access Program in Spain
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Severe Eosinophilic Asthma
Lead sponsor: AstraZeneca
Sponsor class: INDUSTRY
First posted: 2019-10-15
Enrollment: 28
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: RETROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: The study population will be all patients who received at least one dose of benralizumab in individualized access program approved by the AEMPS.

Brief summary: Observational, retrospective study in adults (≥18 years) with severe asthma (maintenance treatment with high dose inhaled corticosteroids combined with long-acting agonist β2) and eosinophilic phenotype, who at the discretion of the investigator were candidates to receive benralizumab in the individualized access program approved by national health authorities.

Primary Objective: To describe the demographic and baseline characteristics in patients with severe eosinophilic asthma who participated in the individualized access program approved in Spain and received at least one dose of benralizumab.

Secondary Objectives: To describe clinical outcomes in severe eosinophilic asthma patients who received at least three doses of benralizumab in the individualized access program.


Eligibility criteria: Inclusion Criteria:

* Adult patients (age ≥18 years)
* Diagnosis of severe eosinophilic asthma requiring stable treatment of high doses of inhaled corticosteroids and a long-acting agonist β2 ± additional asthma controller
* Received at least one dose of benralizumab during the individualized access program period (March-December of 2018)
* Informed consent signed

Exclusion Criteria:

* Patients enrolled in a clinical trial who received benralizumab during the same period of the individualized access program
* Refuse to sign the informed consent

Primary outcomes:
measure: Age
timeFrame: Up to 32 weeks
measure: Sex
timeFrame: Up to 32 weeks
measure: Body Mass Index (BMI)
timeFrame: Up to 32 weeks
measure: Smoking status
timeFrame: Up to 32 weeks
measure: Age at onset of asthma diagnosis
timeFrame: Up to 32 weeks
measure: Comorbidities
timeFrame: Up to 32 weeks
measure: Severe exacerbations
timeFrame: Up to 32 weeks
measure: Emergency room (ER) visits
timeFrame: Up to 32 weeks
measure: Hospitalizations
timeFrame: Up to 32 weeks
measure: Unscheduled visits
timeFrame: Up to 32 weeks
measure: ACT
timeFrame: Up to 32 weeks
measure: miniAQLQ
timeFrame: Up to 32 weeks
measure: Blood eosinophils
timeFrame: Up to 32 weeks
Secondary outcomes:
measure: Incidence of severe exacerbations
timeFrame: Up to 32 weeks
Other outcomes:
Locations:
city: Madrid
country: Spain
facility: BIG PAC
Study officials:
References:
Clinical trial NCT01332799: Xanthine Oxidase Inhibition in Renal Transplant Recipients
Official title: Xanthine Oxidase Inhibition in Renal Transplant Recipients
Study type: INTERVENTIONAL
Overall status: TERMINATED
Phase: PHASE4
Conditions: Complications of Renal Transplant
Keywords: cardiovascular disease
kidney transplantation
Lead sponsor: University of Iowa
Sponsor class: OTHER
First posted: 2011-04-11
Enrollment: 20
Sex: ALL
Minimum age (years): 18
Maximum age (years): 85
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: PREVENTION

Brief summary: Cardiovascular disease is the leading cause of mortality in kidney transplantation. The enzyme xanthine oxidase may play an important role in the cardiovascular disease of kidney transplant recipients. Inhibiting this enzyme with allopurinol may improve vascular health and protects against cardiovascular complications.

Detailed description: This is a prospective, double-blind, placebo controlled, clinical trial examining vascular effects of allopurinol in patients who received a kidney transplant that are maintaining stable renal function for at least 1 year. End-points include pulse-wave velocity, systemic blood pressure and kidney function among others.

Eligibility criteria: Inclusion Criteria:

* age 18 years or older
* both genders
* recipients of living donor or deceased-donor kidney transplant with stable renal function

Exclusion Criteria:

* history of gout
* allergy to allopurinol
* use of azathioprine

Primary outcomes:
measure: Cardiovascular Events
timeFrame: 3 years
measure: Endothelial Function
timeFrame: 3 years
Secondary outcomes:
measure: Arterial Stiffness
timeFrame: 3 years
Other outcomes:
Locations:
city: Iowa City
country: United States
facility: University of Iowa Hospitals and Clinics
state: Iowa
Study officials:
affiliation: University of Iowa
name: Roberto S Kalil, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT00781599: Improving Medication Compliance and Smoking Cessation Treatment Outcomes for African American Smokers
Official title: Improving Medication Compliance and Smoking Cessation Treatment Outcomes for African American Smokers
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Smokers
Keywords: African american
smokers
smoking cessation
African American smokers
Lead sponsor: University of Kansas Medical Center
Sponsor class: OTHER
First posted: 2008-10-29
Enrollment: 72
Sex: ALL
Minimum age (years): 18
Maximum age (years): 75
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: Little is known about the support needed to improve compliance with Chantix for smoking cessation. This is a two arm pilot study of African American smokers to provide varying levels of side effect management and compliance support during a 12 week treatment period. The primary aim of the study is to estimate the effect of induction support compared to standard care in increasing compliance with Chantix at month 3


Eligibility criteria: Inclusion Criteria:

* African American
* 18-75 years of age
* Smoke more than 10 cigarettes per day
* Have a functioning telephone number
* Be interested in quitting smoking
* Be willing to take 3 months of Chantix
* Be willing to complete all study visits

Exclusion Criteria:

* Renal impairment
* Evidence or history of clinically significant allergic reactions to Chantix
* Cardiovascular event in the past month
* History of alcohol or drug abuse/dependency in the past year
* Major depressive disorder in the last year requiring treatment
* History of panic disorder
* Psychosis, bipolar or eating disorder
* Use of antidepressants, antipsychotics, mood stabilizers/anticonvulsants or naltrexone
* Use of tobacco products other than cigarettes
* Use of nicotine replacement therapy, bupropion, clonidine or nortriptyline in the month prior to enrollment
* Prior use of Chantix
* Women who are pregnant, contemplating getting pregnant or breastfeeding
* Plans to move from Kansas City during the 3 month treatment phase
* Another household member enrolled in the study

Primary outcomes:
measure: Percent Compliance With Chantix
timeFrame: Months 1, 2, 3
Secondary outcomes:
measure: Cotinine Verified 7 Day Point Prevalence Smoking Abstinence
timeFrame: Month 3
measure: Carbon Monoxide-verified Abstinence
timeFrame: Month 1
measure: Carbon Monoxide-verified Abstinence
timeFrame: Month 2
Other outcomes:
Locations:
city: Kansas City
country: United States
facility: University of Kansas Medical Center
state: Kansas
Study officials:
affiliation: University of Kansas Medical Center
name: Nicole Nollen, PhD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT06502899: CMR in Myocardial Infarction with Nonobstructive Coronary Arteries
Official title: Prognostic Value of CMR-related Parameters in Patients with MINOCA
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Cardiac Magnetic Resonance
Myocardial Infarction with Nonobstructive Coronary Arteries
Strain
Extracellular Volume
Lead sponsor: The Affiliated Hospital of Xuzhou Medical University
Sponsor class: OTHER
First posted: 2024-07-16
Enrollment: 387
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: RETROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: We consecutively selected patients who were suspected of myocardial infarction with concomitant CAG from January 2019 to June 2024 at the Affiliated Hospital of Xuzhou Medical University. All patients completed CMR during hospitalization. hsTnT peak was above the 99th percentile and CAG less than 50% in all patients.

Brief summary: MINOCA is accompanied by a worse prognosis, which is related to the inability to clarify the etiology.CMR has been explicitly recommended by guidelines as an etiologic diagnostic tool for MINOCA. Although CMR-related parameters, such as strain and ECV, have been shown to be associated with prognosis in patients with myocardial infarction. However, the relationship between CMR-strain or ECV and MINOCA is unclear. The aim of this study was to investigate the characterization of CMR-strain or ECV in patients with MINOCA and the relationship with prognosis.


Eligibility criteria: Inclusion Criteria:

1. Complete CMR during hospitalization;
2. CAG results suggesting coronary stenosis of less than 50%;
3. peak hsTnT above the 99th percentile.

Exclusion Criteria:

* CMR image sequences are missing or of poor quality.

Primary outcomes:
measure: Primary endpoint events included any cause, non-fatal infarction, stroke, or cardiac readmission.
timeFrame: All patients were followed until June 30, 2024
Secondary outcomes:
Other outcomes:
Locations:
city: Xuzhou
country: China
facility: The Affiliated Hospital of Xuzhou Medical University
state: Jiangsu
Study officials:
References: