Clinical trial NCT06209983: The Effect of Enhanced Recovery After Surgery (ERAS) in Gastric Cancer Surgery
Official title: The Effect of Enhanced Recovery After Surgery (ERAS) in Gastric Cancer Surgery
Study type: INTERVENTIONAL
Overall status: ACTIVE_NOT_RECRUITING
Phase: NA
Conditions: Anesthesiology
General Surgery
Keywords: ERAS
Postoperative Complications
Lead sponsor: National Taiwan University Hospital
Sponsor class: OTHER
First posted: 2024-01-18
Enrollment: 38
Sex: ALL
Minimum age (years): 20
Maximum age (years): 80
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The investigators aimed to clarify the clinical relevance of the ERAS protocol by evaluating the perioperative course in patients undergoing laparoscopic gastric cancer surgery.

Detailed description: Gastric cancer is 7th common malignant disease in Taiwan, accounting for 3000 new cases per year. The main treatment of gastric cancer is radical gastrectomy and lymph nodes dissection, which is associated with 13.0\~46 % of surgical morbidities. To minimize the surgical morbidities and enhance patients' recovery, perioperative management is mandatory. Enhanced Recovery After Surgery (ERAS) is a multimodal, multidisciplinary approach to the care of the surgical patient. ERAS process implementation involves a team consisting of surgeons, anesthetists, an ERAS coordinator, and staff from units that care for the surgical patient. The main elements of ERAS include carbohydrate loading before surgery, minimally invasive approaches, balanced management of intravenous fluids, multimodal pain management, early mobilization, and early oral feeding, etc. Some prospective studies have shown its effectiveness in reduce surgical morbidity and hospital stay in colorectal surgery. In Taiwan, there was only limited report to study the use of ERAS in gastric cancer surgery. The investigators would like to integrate these perioperative interventions into the ERAS program, and test its effectiveness in gastric cancer patients undergoing radical gastrectomy at NTUH.

Eligibility criteria: Inclusion Criteria:

* Pathological confirmed as gastric adenocarcinoma;
* Gastric cancer patients who will undergo subtotal gastrectomy.

Exclusion Criteria:

* Advanced gastric cancer with gastric outlet obstruction;
* Epidural catheter placement contraindicated or inexecutable;
* Have other cancers that have received chemotherapy or radiation therapy;
* Coagulation abnormalities;
* Pregnancy;
* Severe dysfunction of major organs (e.g., heart failure, chronic obstructive pulmonary disease, liver cirrhosis, end-stage renal disease)

Primary outcomes:
measure: Length of hospital stay
timeFrame: From date of admission until the date of discharge, assessed up to 2 weeks.
Secondary outcomes:
measure: Complication rates
timeFrame: 28 days
Other outcomes:
measure: Readmission rates
timeFrame: within 28 days
measure: costs of hospitalization
timeFrame: From date of admission until the date of discharge, assessed up to 2 weeks.
Locations:
city: Taipei
country: Taiwan
facility: National Taiwan University Hospital
Study officials:
References: