Clinical trial NCT00985413: Observational Study to Assess Natural History in Cockayne Syndrome Patients
Official title: An Observational Study to Assess the Natural History Including Growth and Hearing in Patients With Cockayne Syndrome
Study type: OBSERVATIONAL
Overall status: TERMINATED
Conditions: Cockayne Syndrome
Keywords: Cockayne Syndrome
pediatrics
growth
hearing
Ageing
Lead sponsor: DNage B.V.
Sponsor class: INDUSTRY
First posted: 2009-09-28
Enrollment: 40
Sex: ALL
Minimum age (years): 1
Maximum age (years): 11
Standard ages: CHILD
Accepts healthy volunteers: no
Observational model: COHORT
Sampling method: PROBABILITY_SAMPLE
Study population: Pediatric patients up to 10 years of age for females and up to 11 years of age for males who have received a diagnosis of Cockayne Syndrome

Brief summary: This is an Observational Study of children under the age of 11 diagnosed with Cockayne Syndrome to assess the natural progression of Cockayne Syndrome disease, with special attention to hearing and physical changes in length or height, weight, head circumference, and arm span during standard treatment.

The primary analytical objective is to determine the rate of linear growth over a 6-month period in children \< 2 years of age and over a 12-month period in children ≥ 2 years of age.


Eligibility criteria: Inclusion Criteria:

* Pediatric patients with a documented diagnosis of CS, as suggested by clinical features and possible confirmation by genetic consultation and analysis
* Age of participation:

  * At least 12 months of age at the time of signing Informed Consent/Assent
  * Female patient's age will not be greater than 10 years of age at the time of signing Informed Consent/Assent
  * Male patient's age will not be greater than 11 years of age at the time of signing Informed Consent/Assent

Exclusion Criteria:

* Severe contractures or physical deformities that in the opinion of the investigator would prevent accurate measurement of height, length and ulna length
* Patients that have taken growth hormone or growth hormone related medications within 12 months prior to the date of Informed Consent/Assent
* Known history of inborn error of hyperprolinemia (Type I or Type II)
* Clinical features present at the time of initial screening that are associated with the terminal phases of the natural progression of CS suggesting safe travel and completion of the study and its assessments to be unlikely as judged by the Investigator, including any of the following:

  * Continuous or intermittent dependence on supplemental oxygen at home during the prior six months
  * Two or more hospitalizations for pneumonia during the prior 12 months;
  * A documented net weight loss of at least 10%, which has not been recovered and which includes a significant net weight loss (beyond the estimated error of the measurement) over the most recent 6 months, despite intensive nutritional support including the use of gastrostomy tube feedings
* Presence of scoliosis with a Cobb's angle of 30º or greater

Primary outcomes:
measure: The primary objective is to determine the rate of linear growth over a 6-month period in children < 2 years of age and over a 12-month period in children ≥ 2 years of age.
timeFrame: 6 -12 months
Secondary outcomes:
measure: Hearing Test Results tabulated and with the severity/deficits to be correlated with patient age, height velocity, and Pediatric Evaluation of Disabilities Inventory (PEDI)Score
timeFrame: 6-12 months
Other outcomes:
Locations:
city: Boston
country: United States
facility: Harvard medical School, Children's Hospital Boston, Division of Genetics & Metabolism
state: Massachusetts
city: New York
country: United States
facility: New York University Medical Center
state: New York
city: Strasbourg
country: France
facility: Hopitaux Universitaires de Strasbourg, Service de Pédiatrie 1
state: Cedex
city: Manchester
country: United Kingdom
facility: St. Mary's Hospital, Genetic Medicine, 6th Floor, Oxford Road
Study officials:
affiliation: Boston Children's Hospital
name: E. G. Neilan, MD, PhD
role: PRINCIPAL_INVESTIGATOR
References: