Clinical trial NCT06366113: Time of Exercise Re-training With Chronic Obstructive Pulmonary Disease (COPD)
Official title: Effect of Time of Exercise Re-training on Functional Capacity in Individuals With Chronic Obstructive Pulmonary Disease (COPD)
Study type: INTERVENTIONAL
Overall status: RECRUITING
Phase: NA
Conditions: Respiratory Diseases
Keywords: respiratory diseases
pulmonary rehabilitation
chronic obstructive pulmonary disease
biological clock
Lead sponsor: Clinique de la Mitterie
Sponsor class: OTHER
First posted: 2024-04-15
Enrollment: 90
Sex: ALL
Minimum age (years): 18
Maximum age (years): 85
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: PREVENTION

Brief summary: Pulmonary rehabilitation (PR) is an effective intervention for reducing hospital readmissions, secondary events, and mortality in patients with respiratory pathologies.

The program should not be improved by introducing new subjects such as circadian rhythm.

Detailed description: Respiratory diseases are a leading cause of death in developed countries. To avoid complications and recurrences, secondary prevention in patients with respiratory diseases is essential. Pulmonary rehabilitation (PR) is a well-established and effective treatment that is supervised by medical professionals and conducted in dedicated centres. It has been shown to reduce hospital readmissions, secondary events, and patient mortality.

The timing of reconditioning is crucial. Previous studies have indicated that training times affect strength and power gains. Additionally, the time of day for training can significantly impact progress in aerobic capacity.

Disturbances to the biological clock can have consequences for people with respiratory pathologies, particularly an alteration in muscular function.

Therefore, studying the temporal specificity of exercise re-training in patients with respiratory diseases is of interest.

Eligibility criteria: Inclusion Criteria:

* Age ≥ 18 years
* Patient with chronic obstructive pulmonary disease (COPD)
* Registered for respiratory re-education and rehabilitation at the Clinique de la Mitterie
* Number of rehabilitation sessions at least 18 over 4 weeks
* Written informed consent signed by the patient
* Membership of a social security

Exclusion Criteria:

* - cardiovascular contraindications to exercise
* unstable respiratory status (uncompensated respiratory acidosis)
* conditions interfering with the pulmonary rehabilitation process (progressive neuromuscular disease, psychiatric illness)

Primary outcomes:
measure: 6-minute walk test (6MWT)
timeFrame: 15 minutes
Secondary outcomes:
measure: Time limit test (Time-lim)
timeFrame: 0 to 900 secondes
measure: Sit to stand test (STT)
timeFrame: 1 minute
measure: Single arm curl Test (SAC)
timeFrame: 1 minute
measure: Single-leg stance test (SLT)
timeFrame: 1 minute
measure: Hospital Anxiety and Depression Scale (HAD)
timeFrame: 10 minutes. The maximum mark for each score is 21 and the minimum mark is 0. The higher the score, the more depressed or anxious the person.
measure: Pittsburgh Sleep Quality Index
timeFrame: 10 minutes. The total score ranges from 0 to 21, with 0 indicating no difficulties and 21 indicating major difficulties.
Other outcomes:
Locations:
city: Lille
country: France
facility: Clinique la Mitterie
Study officials:
References: