Clinical trial NCT05525299: Reminiscence-Based Life Review on Copying With Existential Suffering Among Older Cancer Survivors
Official title: The Effects of a Reminiscence-Based Life Review on Copying With Existential Suffering Among Older Cancer Survivors With Cognitive Impairment
Study type: INTERVENTIONAL
Overall status: RECRUITING
Phase: NA
Conditions: Existential Suffering
Meaning of Life
Cognitive Function
Psychological Distress
Social Support
Lead sponsor: The University of Hong Kong
Sponsor class: OTHER
First posted: 2022-09-01
Enrollment: 116
Sex: ALL
Minimum age (years): 65
Standard ages: OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: SUPPORTIVE_CARE

Brief summary: Target Issue:

Cognitive impairment in older cancer survivors is highly prevalent and the co-existing neuro-psychiatric symptoms, particularly depression, would further complicate the psychosocial consequence of existential suffering. However, no reminiscence-based interventions are specifically developed for older people with cancer have been developed and evaluated.

Target Population:

Cancer survivors aged 65 years old and above with a mild cognitive impairment identified by the HK-MoCA 5-Min Protocol cognitive assessment.

Intervention:

This research project aims to implement a brief reminiscence-based intervention that includes six reminiscence chatting sessions among older cancer survivors. The proposed reminiscence-based intervention has great potential to provide psychological and spiritual care as well as comfort to those who are weak, aged and are in need of assistance.

Study Objectives:

1. To evaluate the effect of a reminiscence-based life review intervention on copying with existential suffering including meaning of life (primary outcome), cognitive function, psychological distress and social support (secondary outcomes) in older cancer survivors
2. To explore older cancer survivors' experience of the intervention regarding the impact of the intervention on their existential suffering

Study Method:

The investigator will recruit 116 voluntary elder patients from the outpatient oncology clinics of the Queen Mary Hospital to participate in the study. They will be individually randomized at a 1:1 ratio to receive usual care or the brief reminiscence-based intervention at home. Outcomes will be assessed at baseline (T0), post-intervention (T1), and 6-week follow-up (T2). A qualitative interview regarding the feedback on the intervention will be undertaken only in the intervention group.


Eligibility criteria: Inclusion Criteria:

* Aged ≥ 65 years
* Diagnosed with stage I-III non-metastatic cancer
* Completed primary treatment with curative intent (surgery, chemotherapy, and/or radiation therapy) 6 months to 5 years prior to baseline assessments with no recurrence or occurrence of additional cancers
* identified as mild cognitive impairment by the HK-MoCA 5-Min Protocol cognitive assessment (≤ 7th age and education corrected percentile cutoff score)

Exclusion Criteria:

* Inadequate written and verbal Cantonese and/or English comprehension for study activities
* Diagnosed with dementia

Primary outcomes:
measure: Purpose in life
timeFrame: up to 6 weeks
Secondary outcomes:
measure: Cognitive function
timeFrame: up to 6 weeks
measure: Psychological distress
timeFrame: up to 6 weeks
measure: Perceived social support
timeFrame: up to 6 weeks
Other outcomes:
Locations:
city: Hong Kong
country: Hong Kong
facility: School of Nursing, The University of Hong Kong
Study officials:
affiliation: The University of Hong Kong
name: Mu-Hsing Ho, PhD
role: PRINCIPAL_INVESTIGATOR
References: