louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT02330718: Prospective and Retrospective Cohort Study to Find New Prognostic Factors and Therapeutic Targets in Patients With Newly Diagnosed or Relapsed Malignant Hematologic Disorder Excluding Acute Leukemia
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Malignant Hematologic Disorder
Lead sponsor: Yonsei University
Sponsor class: OTHER
First posted: 2015-01-05
Enrollment: 1500
Sex: ALL
Minimum age (years): 19
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: OTHER
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Patients with newly diagnosed or relapsed malignant hematologic disorders except acute leukemia

Brief summary: The purpose of this study is to elucidate the factors which are associated with the diagnosis and predict prognosis and therapeutic targets by collecting specimens of tissue sample, peripheral blood, and bone marrow aspirates at the time of diagnosis or relapse/refractory in patients with malignant hematologic disorders except acute leukemia. This study is eligible for patients who are diagnosed with malignant hematologic disorders except acute leukemia or who will have diagnostic procedure with suspicion of having hematologic malignancy. Prospective cohort is for patients who are not in treatment for hematologic malignancy. Retrospective cohort is for patients who are diagnosed and in treatment.


Eligibility criteria: Inclusion Criteria:

* The patients with malignant hematologic disorders except acute leukemia who are diagnosed pathologically according to the revised 2008 WHO classification of tumours of haematopoietic and lymphoid tissue or who will have diagnostic procedure with suspicion of having hematologic malignancy.
* Any gender and age ≥ 19 years
* Written informed consent
* Diagnosed after 2005-01-01 in retrospective cohort group.

Exclusion Criteria:

* Patients who cannot understand or disagree the informed consent
* Patients who diagnosed with acute leukemia

Primary outcomes:
measure: the number of patients with malignant hematologic disorders to examine the new prognostic factors and therapeutic targets
timeFrame: 5 years
Secondary outcomes:
Other outcomes:
Locations:
city: Seoul
country: Korea, Republic of
facility: Severance Hospital
Study officials:
References:
Clinical trial NCT05810818: Effectiveness Of DN and STM Combined With Self-Stretching for Management of Calf and Heel Pain
Official title: Effectiveness Of Dry Needling and Soft Tissue Mobilization Combined With Self-Stretching for Management of Calf and Heel Pain
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Heel Pain Syndrome
Lead sponsor: Superior University
Sponsor class: OTHER
First posted: 2023-04-12
Enrollment: 54
Sex: ALL
Minimum age (years): 25
Maximum age (years): 60
Standard ages: ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: HEALTH_SERVICES_RESEARCH

Brief summary: To determine the effectiveness of dry needling and soft tissue mobilization with self-stretching for the management of calf and heel pain. In our topic pain and physical dysfunction are our variables


Eligibility criteria: Inclusion Criteria:

* Patients will be between the ages of 25 to 60 years.
* Female and males.
* History of heel and calf pain.
* Pain level moderate .
* Trigger point / inactive trigger points.
* Acute stage patients.

Exclusion Criteria:

* Phobias like injections or needles.
* Unwilling patients
* Patients on anticoagulant medicines.
* Patients with RA
* Fibromyalgia syndrome.
* Pateint with recent trauma and surgery.

Primary outcomes:
measure: Dry Needling and Soft Tissue Mobilization with Self-Stretching
timeFrame: 6 Months
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
References:
Clinical trial NCT01376518: Influence Positive End-expiratory Pressure on Autoregulation in Patients With Respiratory Insufficiency
Official title: Influence of Positive End-expiratory Pressure on the Cerebrovascular Autoregulation in Patients With Respiratory Failure
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Respiratory Insufficiency
Keywords: acute respiratory distress syndrome
acute lung injury
cerebrovascular autoregulation
transcranial Doppler
ventilation
Lead sponsor: Johannes Gutenberg University Mainz
Sponsor class: OTHER
First posted: 2011-06-20
Enrollment: 20
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: OTHER
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: Adult patients on intensive care unit with acute respiratory failure

Brief summary: The aim of the present study is to characterize the influence of an elevated positive end-expiratory pressure in patients with acute respiratory distress syndrome or acute lung injury on the cerebrovascular autoregulation.

Detailed description: Cerebral blood flow velocity will be measured using transcranial Doppler sonography and then correlate with the invasive arterial blood pressure curve to calculate the index of cerebrovascular autoregulation Mx (Mx\>0.3 indicates impaired AR). The index of cerebrovascular autoregulation Mx was measured during baseline positive end-expiratory pressure (PEEP) levels and after lung recruitment with higher level of PEEP. The equality between this two PEEP levels was estimated and calculated with one side Wilcoxon test.

Eligibility criteria: Inclusion Criteria:

* respiratory failure
* Age \>18 years
* Invasive ventilation

Exclusion Criteria:

* Sepsis
* preexisting cerebral illness
* traumatic brain injury
* meningitis or encephalitis
* pregnancy

Primary outcomes:
measure: Integrity of the cerebrovascular autoregulation (CA)
timeFrame: 30 Minutes
Secondary outcomes:
Other outcomes:
Locations:
city: Mainz
country: Germany
facility: University medical centre
Study officials:
affiliation: Department of Anesthesiology, University medicine Mainz, Germany
name: Patrick Schramm, MD
role: PRINCIPAL_INVESTIGATOR
References:
citation: Schramm P, Closhen D, Felkel M, Berres M, Klein KU, David M, Werner C, Engelhard K. Influence of PEEP on cerebral blood flow and cerebrovascular autoregulation in patients with acute respiratory distress syndrome. J Neurosurg Anesthesiol. 2013 Apr;25(2):162-7. doi: 10.1097/ANA.0b013e31827c2f46.
Clinical trial NCT02638818: Outcomes in Minimally Invasive Versus Open Pancreaticoduodenectomy
Official title: A Pilot Study Evaluating Health-related Quality of Life Endpoints in Patients Undergoing Minimally Invasive Versus Open Pancreaticoduodenectomy
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Pancreatic Disease
Keywords: pancreaticoduodenectomy
Whipple
Lead sponsor: Duke University
Sponsor class: OTHER
First posted: 2015-12-23
Enrollment: 57
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: All patients scheduled for pancreaticoduodenectomy will be eligible for this study.

Brief summary: The purpose of this study is to evaluate the impact of the quality of life in patients undergoing the Whipple procedure (pancreaticoduodenectomy, PD) for pancreatic cancer. The Whipple procedure can be done by laparoscopic (small incisions) or an open procedure (large incision) to treat the patients cancer. The goal of this study is to see if there is any difference in quality of life between patients who undergo the laparoscopic or the open Whipple procedure. Surgical technique (minimally invasive versus open) will be at the discretion of the operating surgeon. Patients will not be randomized to a treatment arm.

A subset of these patients will also be asked to take part in a pre- and postoperative in-depth interview to explore the lived experiences of patients with resectable pancreatic cancer.


Eligibility criteria: Inclusion Criteria:

* All patients scheduled for pancreaticoduodenectomy will be eligible for this study.
* Subject must be at least 18 years of age and at least the minimum Age of Majority according to applicable State or Country Law.
* Subject is a suitable surgical candidate, i.e. is able to undergo general anesthesia and PD for diagnosis of cancer
* Subject is willing and able to cooperate with survey participation.
* Subject has been informed of the study procedures and the treatment and has signed an informed consent form

Exclusion Criteria:

• Subject is not a suitable candidate for PD

Primary outcomes:
measure: Change in quality of life, as measured by FACT-Hep score
timeFrame: Baseline (before surgery), at hospital discharge (up to approximately 14 days), at first clinic visit (within 2 weeks after discharge), 3 months
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
References:
Clinical trial NCT02377518: DECT Ventilation Imaging
Official title: Quantitative Ventilation Imaging With Dual Energy Computed Tomography
Study type: INTERVENTIONAL
Overall status: TERMINATED
Phase: NA
Conditions: For Oncologic Patients
Potentially Operable Lung Tumor
With a Recent (Less Than 1 Month) VQ Scan
For Lung Transplant Recipients
Single of Bilateral Lung Transplant
From 5 Months Onwards
With Recent (Less Than 1 Month) Respiratory Functional Explorations
Lead sponsor: University Hospital, Strasbourg, France
Sponsor class: OTHER
First posted: 2015-03-03
Enrollment: 10
Sex: ALL
Minimum age (years): 18
Maximum age (years): 85
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NON_RANDOMIZED
Intervention model: PARALLEL
Primary purpose: DIAGNOSTIC

Brief summary: Demonstrate the feasibility of dual energy computed tomography using Krypton as a gaseous contrast media in order to study the in vivo ventilation.

Two different clinical situations will be tested :

* Prediction of postoperative pulmonary function for oncologic patients
* Detection of Bronchiolitis Obliterans in lung transplant recipients.


Eligibility criteria: Inclusion criteria:

For oncologic patients :

* Potentially operable lung tumor
* With a recent (less than 1 month) V/Q scan

For lung transplant recipients :

* Single of bilateral lung transplant
* From 5 months onwards
* With recent (less than 1 month) respiratory functional explorations

Exclusion criteria:

* Impossibility to follow simple orders or control one's respiration
* Known Krypton hypersensitivity
* History of malignant hyperthermia
* Increased intracranial pressure
* Minors
* Pregnant Women

Primary outcomes:
measure: Image quality on a qualitative 5 levels scale
timeFrame: 1 day of DECT ventilation imaging
Secondary outcomes:
measure: Radiation dose
timeFrame: 1 day of DECT ventilation imaging
measure: Image noise with measurement of signal to noise and contrast to noise ratios
timeFrame: 1 day of DECT ventilation imaging
measure: Total examination time
timeFrame: 1 day of DECT ventilation imaging
Other outcomes:
Locations:
city: Strasbourg
country: France
facility: Service de Radiologie B - Nouvel Hôpital Civil - CHRU de Strasbourg
Study officials:
References:
Clinical trial NCT06174818: Pulsed Radiofrequency Treatment Of the Gasserian Ganglion for tRigeminal nEuralgia: a retroSpective Study
Official title: Pulsed Radiofrequency Treatment Of the Gasserian Ganglion for tRigeminal nEuralgia: a retroSpective Study
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Trigeminal Neuralgia (TN)
Lead sponsor: Ziekenhuis Oost-Limburg
Sponsor class: OTHER
First posted: 2023-12-18
Enrollment: 85
Sex: ALL
Minimum age (years): 18
Maximum age (years): 99
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: OTHER
Time perspective: RETROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Patients with trigeminal neuralgia who underwent their first PRF of the Gasserian ganglion between 01/09/2013 and 31/08/2021

Brief summary: With the Pulsed Radiofrequency treatment (PRF) Of the Gasserian ganglion for tRigeminal nEuralgia: a retroSpective Study (PROGRESS) the objective is to document the outcome of PRF (Pulsed Radiofrequency treatment) for patients with TN (Trigeminal Neuralgia), unresponsive to conservative treatment.

Detailed description: Primary objective:

To determine the proportion of patients in which PRF (pulsed radiofrequency) of the Gasserian ganglion for trigeminal neuralgia (TN) provides acute pain relief of at least 50% on the GPE (Global perceived effect) score (six weeks after treatment)

Secondary objectives:

- To determine the duration during which PRF of the Gasserian ganglion for trigeminal neuralgia provides a reduction of at least 50% on the GPE (Grade Point Equivalent) score.

Eligibility criteria: Inclusion Criteria:

* Patients with trigeminal neuralgia who underwent their first PRF of the Gasserian ganglion between 01/09/2013 and 31/08/2021

Exclusion Criteria:

* None

Primary outcomes:
measure: GPE <50%
timeFrame: Six weeks after treatment
Secondary outcomes:
measure: Duration of GPE <50%
timeFrame: From six weeks post procedure until definitive or possible relapse of neuralgia, assessed up to 48 months.
Other outcomes:
Locations:
city: Genk
country: Belgium
facility: ZOL Ziekenhuis Oost-Limburg
state: Limburg
Study officials:
References:
Clinical trial NCT01922518: Impact of Right Ventricular Pacing Determined by Electrocardiography
Official title: Impact of Right Ventricular Pacing Determined by Electrocardiography; Prospective Randomized Trial
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Atrioventricular Block
Keywords: atrioventricular block, cardiomyopathy
Lead sponsor: Seoul St. Mary's Hospital
Sponsor class: OTHER
First posted: 2013-08-14
Enrollment: 233
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: Typically pacemaker electrode has been attached to the right ventricular apex. This method lead to Non-physiological Ventricular contraction. It has been reported to cause by ventricular dysfunction. In conclusion, this study demonstrate that impact of right ventricular pacing determined by electrocardiography was planned.

Detailed description: Patients who has Atrioventricular block scheduled for artificial pacemaker Randomized select 1:1 apex beats and ventricular septal beat.

Eligibility criteria: Inclusion Criteria:

* Atrioventricular block, pacemaker scheduled

Exclusion Criteria:

* History of myocardial infarction
* Valvular heart disease (grade ≥ 2 )
* History of Left ventricular dysfunction ( ejection fraction \<50% or LV dimension \>60 mm in the pre-procedure echocardiogram)

Primary outcomes:
measure: > 10% decrease of ejection fraction
timeFrame: 3 years
Secondary outcomes:
Other outcomes:
Locations:
city: Seoul
country: Korea, Republic of
facility: Seoul st. mary's hospital
state: Seo Cho Gu
Study officials:
affiliation: Seoul St. Mary's Hospital
name: Yong seog Oh, MD
role: PRINCIPAL_INVESTIGATOR
References:
citation: Kim SH, Oh YS, Nam GB, Choi KJ, Park JS, Park SW, Park SJ, On YK, Kim JS, Shin WS, Kim JH, Jang SW, Lee MY, Kim YH, Rho TH. Paced QRS axis as a predictor of pacing-induced left ventricular dysfunction. J Interv Card Electrophysiol. 2014 Dec;41(3):223-9. doi: 10.1007/s10840-014-9950-7. Epub 2014 Nov 8.
Clinical trial NCT01168518: An Observational Study on the Sorin Group New Brady Leads XFine and Beflex
Official title: Performance of the New Generation of Sorin Group Brady Leads In a Normal Hospital Practice
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Pacing Leads Implantation
Keywords: Evaluate the Sorin Group new passive- and active- fixation pacing leads
Lead sponsor: LivaNova
Sponsor class: INDUSTRY
First posted: 2010-07-23
Enrollment: 2254
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: Any patient implanted with an endocavitary pacing lead (atrial and/or ventricular) connected to a single, double or triple chamber pacemaker or defibrillator.

Brief summary: This observational study is a non-interventional multi-centre, prospective study.

The aim of the study is to evaluate the Sorin Group new passive- and active- fixation pacing leads. We plan to assess the acute and short term lead dislodgment rate (within the first three months following implantation) correlated with the type of lead (active- or passive- fixation). Further, we are collecting data related to leads handling and leads electrical performances

Detailed description: The primary objective of this observational study is to assess the acute rate of dislodgment of the new Sorin group range of active- and passive- fixation leads up to 3 months following implant.

Assessment of electrical performances (pacing threshold, sensing amplitude, impedance) of the leads at implant and during follow-up.

Eligibility criteria: Inclusion Criteria:

* The implanted lead must allow the measurement of pacing threshold at 0.5ms, R-wave or P-wave amplitude and impedance of the lead.
* Included patients may receive more than one lead under evaluation.

Exclusion Criteria:

* Any contraindication to endocavitary lead implantation;
* Inability to understand the purpose of the study or refusal to co-operate.
* Geographically unstable or unavailability for scheduled M1-M3 follow-up at the implanting centre as defined in the investigational plan.
* Patient of minor age (\<18)
* Pregnancy.

Primary outcomes:
measure: Lead dislodgment rate in acute phase
timeFrame: Lead dislodgment
Secondary outcomes:
Other outcomes:
Locations:
city: Perpignan
country: France
facility: Clinique St Pierre
Study officials:
affiliation: Unité de Cardiologie et Rythmologie Interventionelle, Perpignan France
name: Henri Benkemoun, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT02534818: Different Fluorescein Sodium Dosage for the Detection of Gastric Intestinal Metaplasia
Official title: Conventional Fluorescein Sodium Dosage o.1ml/kg Compared With a Lower Fluorescein Sodium Dosage o.02ml/kg for the Detection of Gastric Intestinal Metaplasia in a High Risk Population: a Randomized Controlled Trial
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: PHASE4
Conditions: Gastric Intestinal Metaplasia
Lead sponsor: Shandong University
Sponsor class: OTHER
First posted: 2015-08-28
Enrollment: 180
Sex: ALL
Minimum age (years): 40
Maximum age (years): 80
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: DIAGNOSTIC

Brief summary: The purpose of this study is to assess whether lower fluorescein sodium dosage can perceive the same detection rate per patient and per lesion for the detection of gastric intestinal metaplasia.

Detailed description: Gastric intestinal metaplasia is regarded as an important premalignant lesion for intestinal type gastric cancer. Currently, the histological assessment of gastric intestinal metaplasia still relies on the biopsies took from five sites that the updated Sydney System recommended.

This study aims to compare the diagnostic yield of gastric intestinal metaplasia from two different fluorescein sodium dosage and assess whether lower fluorescein sodium dosage can perceive the same detection rate per patient and per lesion for the detection of gastric intestinal metaplasia.

Eligibility criteria: Inclusion Criteria:

* patients with dyspeptic symptoms and aged 40 years or older
* or patients with Helicobacter pylori infection, or histologically verified gastric intestinal metaplasia or atrophic gastritis
* or patients with family history of gastric cancer

Exclusion Criteria:

* presence of gastrectomy, acute gastrointestinal bleeding, or known gastric neoplasia
* presence of conditions unsuitable for endoscopy procedure including coagulopathy, impaired cardiopulmonary function , pregnancy or breastfeeding
* inability to provide informed consent

Primary outcomes:
measure: Difference of the detection rate of gastric intestinal metaplasia between two fluosecein sodium dosage in a per-pateint analysis
timeFrame: six months
measure: Difference of the detection rate of gastric intestinal metaplasia between two dosage fluosecein sodium in a per-biopsy analysis
timeFrame: six months
Secondary outcomes:
Other outcomes:
Locations:
city: Jinan
country: China
facility: Department of Gastroenterology, Qilu Hospital, Shandong University
state: Shandong
Study officials:
affiliation: Department of Gastroenterology, Qilu Hospital, Shandong University
name: Yanqing Li, PhD. MD
role: STUDY_DIRECTOR
References:
Clinical trial NCT00573118: Severe Pregnancy Complications Are Associated With Elevated Factor VIII Plasma Activity
Official title: A Retrospective Analysis of Possible Association Between Severe Pregnancy Complications and Elevated Factor VIII Plasma Activity.
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Pregnancy Complications
Preeclampsia
Placental Abruption
Intrauterine Fetal Growth Restriction
Intrauterine Fetal Death
Keywords: Pregnancy complications: preeclampsia , severe IUGR , IUFD or placental abruption (n = 5).
Lead sponsor: Tel-Aviv Sourasky Medical Center
Sponsor class: OTHER_GOV
First posted: 2007-12-13
Enrollment: 100
Sex: FEMALE
Minimum age (years): 18
Maximum age (years): 45
Standard ages: ADULT
Accepts healthy volunteers: no
Observational model: CASE_CONTROL
Time perspective: RETROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: women who had either normal pregnancy or complicated pregnancy

Brief summary: Congenital and acquired thrombophilia were identified as risk factors for thrombosis in systemic vessels.Thrombophilias have also been recently found to be associated with preeclampsia, intrauterine fetal growth restriction (IUGR), placental abruption, intrauterine fetal death (IUFD) and repeated pregnancy loss.These severe pregnancy complications are thought to result from thrombotic events occurring in the uteroplacental circulation. Accumulating data have established an association between elevated plasma activity of factor VIII and thrombosis although the mechanism is still not defined and elevated factor VIII activity is now regarded as being equivalent to thrombophilia.

We intend to investigatthe association between factor VIII levels and severe pregnancy complications which are considered to result from placental vascular pathology, i.e., preeclampsia, IUGR, placental abruption and IUFD. We hypothezise that the prevalence of elevated factor 8 will be higher among women with pregnancy complications compared to controls.


Eligibility criteria: Inclusion Criteria:

* Women who had either normal pregnancy or complicated pregnancy.

Exclusion Criteria:

* Other causes of pregnancy complication such as infections, anomalies and fetal malformations

Primary outcomes:
measure: prevalenc of elevated factor VIII
timeFrame: RETROSPECTIVE
Secondary outcomes:
Other outcomes:
Locations:
city: Tel Aviv
country: Israel
facility: Tel Avis sourasky medical center
Study officials:
affiliation: Tel Aviv medical center,Israel
name: Eli Rimon, MD
role: PRINCIPAL_INVESTIGATOR
References: