Clinical trial NCT05736770: Pre-operative Respiratory Rehabilitation in Coronary Artery Bypass Graft Patients
Official title: Effect of Pre-operative Respiratory Rehabilitation on Post- Operative Outcomes in Coronary Artery Bypass Graft Patients
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Respiratory Rehabilitation
Lead sponsor: Riphah International University
Sponsor class: OTHER
First posted: 2023-02-21
Enrollment: 86
Sex: ALL
Minimum age (years): 40
Maximum age (years): 65
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: To compare the effects of conventional preoperative respiratory rehabilitation and specific preoperative respiratory rehabilitation program on pulmonary functions in coronary artery bypass graft patients.

Detailed description: After cardiac surgeries many postoperative changes occur that lead to pulmonary complication such as respiratory changes, functional capacity of lungs and gaseous changes that leads to hypoxemia and ischemic injury of lungs. CABG, although a successful procedure, post operative pulmonary complications still pursue a big challenge to the health and fitness of the patients. Although post operative complications have been managed in in-patient setup post CABG, there are pre-operative measures on the rise to prevent the complications to occur after CABG.

This study will contribute in describing the rate of improvement in pulmonary functions with rehabilitation program including preoperative out of bed mobilization, active cycle breathing techniques, forced expiratory technique and volume-based incentive spirometry as compared to the conventional treatment of flow-based incentive spirometry and chest percussion in prevention of post operative pulmonary complications occurring after CABG leading to delayed recovery of patients.

Eligibility criteria: Inclusion Criteria:

* Patients undergoing elective Coronary Artery Bypass Grafting (CABG) surgery for Triple vessel coronary artery disease (TVCAD), double vessel coronary artery disease (DVCAD), single vessel coronary artery disease (SVCAD) and left main stem (LMS) disease.
* Patients who cover at least 400 steps on 6-minute walk test.
* Patients with ejection fraction 45% or more

Exclusion Criteria:

* Acute ailments i.e., patient's cardiac condition deteriorating.
* Cardiac emergency (shock, acute MI)
* Presence of neurological disorders e.g., altered state of consciousness, paralysis.
* Redo surgeries
* Any musculoskeletal disorder e.g., amputation of limb, problems of balance and risks of fall, muscles weakness grade 3 or less, osteoporosis; leading to limitation in exercise.

Primary outcomes:
measure: Forced expiratory volume in one second (FEV1)
timeFrame: 4th postoperative day of coronary artery bypass graft (CABG)
measure: Forced Vital Capacity (FVC)
timeFrame: 4th postoperative day of coronary artery bypass graft (CABG)
measure: Ratio of Forced expiratory volume in 1 second and Forced Vital Capacity (FEV1/FVC)
timeFrame: 4th postoperative day of coronary artery bypass graft (CABG)
Secondary outcomes:
measure: 6-minute walk test (6MWT)
timeFrame: 4th postoperative day of coronary artery bypass graft (CABG)
measure: Borg scale
timeFrame: 4th postoperative day of coronary artery bypass graft (CABG)
Other outcomes:
Locations:
city: Rawalpindi
country: Pakistan
facility: Muhammad ali awan
state: Punjab
Study officials:
affiliation: Riphah International University
name: Muhammad Ali Awan, MS-CPPT
role: PRINCIPAL_INVESTIGATOR
References: