Clinical trial NCT03731936: Artificial Intelligence to Assess the Association Between Facial Characteristics and Coronary Artery Diseases
Official title: Artificial Intelligence to Assess the Association Between Facial Characteristics and Coronary Artery Diseases
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Coronary Artery Disease
Keywords: artificial intelligence
facial characteristics
Lead sponsor: China National Center for Cardiovascular Diseases
Sponsor class: OTHER_GOV
First posted: 2018-11-06
Enrollment: 6864
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: CASE_CONTROL
Time perspective: CROSS_SECTIONAL
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Patients who undergo coronary angiography or coronary computer tomography angiography from both resident patients and outpatient.

Brief summary: The purposes of this study are 1) to explore the association between facial characteristics and the increased risk of coronary artery diseases; 2) to evaluate the diagnostic efficacy of appearance factors for coronary artery diseases.

Detailed description: Several age-related appearance factors were described associated with increased risk of coronary artery diseases (CAD). However, several limitations made these facial risk factors hard to be utilized in clinical practice, including 1) low prevalence in CAD patients, 2) lack of specific definition, 3) poor reproducibility in artificial recognition.

Thus, the investigators designed a multi-center, cross-sectional study to explore the association between facial characteristics and CAD and evaluate the diagnostic efficacy of appearance factors for CAD. The investigators will recruit patients undergoing coronary angiography or coronary computer tomography angiography. Patients' baseline information and facial images will be collected. First, the investigators will explore the facial factors associated with CAD by using artificial intelligence technology to compare facial photographs between patients with CAD and without CAD. Secondary, the investigators will evaluate the dose-response relationship between facial characteristics and CAD. Third, the investigators will establish a CAD risk model based on facial factors, and evaluate the diagnostic effect of the model.

Eligibility criteria: Inclusion Criteria:

* Undergoing coronary angiography or coronary computer tomography angiography
* Written informed consent

Exclusion Criteria:

* Prior percutaneous coronary intervention (PCI)
* Prior coronary artery bypass graft (CABG)
* Screening coronary artery disease before treating other heart diseases
* Without blood biochemistry outcome
* With artificially facial alteration (i.e. cosmetic surgery, facial trauma or make-up)
* Other situations which make patients fail to be photographed

Primary outcomes:
measure: Sensitivity of diagnostic model
timeFrame: at the end of enrollment (6 months)
Secondary outcomes:
measure: Specificity of diagnostic model
timeFrame: at the end of enrollment (6 months)
measure: Specificity of diagnostic model
timeFrame: at the end of enrollment (6 months)
measure: Positive predictive value (PPV)
timeFrame: at the end of enrollment (6 months)
measure: Negative predictive value (NPV)
timeFrame: at the end of enrollment (6 months)
measure: Diagnostic accuracy rate
timeFrame: at the end of enrollment (6 months)
Other outcomes:
Locations:
city: Beijing
country: China
facility: Beijing Anzhen hospital
state: Beijing
city: Beijing
country: China
facility: Fuwai hospital
state: Beijing
city: Beijing
country: China
facility: Guanganmen Hospital, Chinese Academy of Traditional Chinese Medicine
state: Beijing
city: Wuhan
country: China
facility: Wuhan union hospital
state: Hubei
city: Xuzhou
country: China
facility: Xuzhou third people's hospital
state: Jiangsu
city: Dalian
country: China
facility: The first affiliated hospital of Dalian medical university
state: Liangning
city: Shanghai
country: China
facility: Shanghai East hospital
state: Shanghai
city: Shanghai
country: China
facility: Shanghai Renji hospital
state: Shanghai
city: Wenzhou
country: China
facility: The fisrt affiliated hospital of Wenzhou medical university
state: Zhejiang
Study officials:
References: