louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT04205747: Validity and Reliability of Vietnamese Version of 17items-Hamilton Depression Rating Scale
Official title: Department of Psychiatry University of Medicine and Pharmacy at Ho Chi Minh City
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Depression, Unipolar
Lead sponsor: University of Medicine and Pharmacy at Ho Chi Minh City
Sponsor class: OTHER
First posted: 2019-12-19
Enrollment: 200
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: CASE_CROSSOVER
Time perspective: CROSS_SECTIONAL
Sampling method: PROBABILITY_SAMPLE
Study population: Patients are diagnosied depressive disorder at Psychiatric and neurologic department at Unoversity of medicine and pharmacy Hochiminh city hospital

Brief summary: this reseach examines the reliability and validity of 17 items- Hamilton Depression rating scale in Vietnamese population, which has been commonly used in clinical depression practice and study.

Detailed description: - Cross-sectional study

Eligibility criteria: Inclusion Criteria:

* patients accept paticipating in reasearch

Exclusion Criteria:

* patients don't answer full HRDS

Primary outcomes:
measure: validity and reliability of Vietnamese version of HDRS -17
timeFrame: 2020-2021
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
References:
Clinical trial NCT05627947: Comparison Between Topical Mitomycin C and Cyclosporine
Official title: Comparison Between Topical Mitomycin C and Cyclosporine After Primary Pterygium Surgery
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE1
Conditions: Pterygium
Lead sponsor: Egymedicalpedia
Sponsor class: INDUSTRY
First posted: 2022-11-28
Enrollment: 57
Sex: ALL
Minimum age (years): 45
Maximum age (years): 65
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Intervention model description: compare the recurrence rates and complications associated with instillation of topical mitomycin C and cyclosporine after primary pterygium surgery
Primary purpose: TREATMENT

Brief summary: Pterygium is a disease associated with proliferation of the fibrovascular tissues of the conjunctiva into the cornea and is related to factors such as ultraviolet light exposure, chronic stimulation, inflammation, climate, and genetics.

Detailed description: The first line of treatment for primary pterygium is surgical excision, and despite postoperative adjuvant therapy using mitomycin C, cyclosporine, β-irradiation, argon laser, and bevacizumab, recurrence rates remain high .

Mitomycin C is a metabolic inhibitor extracted from Streptomyces caespitosus that inhibits DNA synthesis .

Cyclosporine is an immunosuppressant that selectively suppresses T-helper cells, controls interleukin synthesis and secretion, and inhibits vascular endothelial growth factor (VEGF)

Bevacizumab is an anti-VEGF antibody that inhibits angiogenesis. Each agent has been studied as an adjuvant therapy to inhibit post-surgery pterygium recurrence.

Eligibility criteria: Inclusion Criteria:

* Diagnosis of primary pterygium
* Pterygium size \> or equal 2mm (the horizontal length of the tissue from limbus to cornea will be measured by slit lamp biomicroscopy).
* Ocular discomfort refractory to medical treatment.
* Visual loss induced by pterygium.
* Adult Egyptian population

Exclusion Criteria:

* Patients who had recurrent pterygium or allergy to topical Cyclosporine.
* Patients who had allergy from Mitomycin C.
* Pregnant women.
* Patients with uncontrollable systemic diseases such as hypertension, diabetes, or cardiovascular diseases.
* Patients with diseases of the eye surface such as conjunctivitis and keratitis.
* Patients with a history of eye surgery within the previous six months.

Primary outcomes:
measure: Post Operative recurrence of pterygium
timeFrame: from baseline to 3 months after primary pterygium surgery.
Secondary outcomes:
Other outcomes:
Locations:
city: Shibīn Al Kawm
country: Egypt
facility: Faculty of Medicine, Menoufia University
Study officials:
affiliation: Department of ophthalmology Faculty of Medicine, Menoufia University
name: Marwa Zaki, Assist.Prof.
role: STUDY_CHAIR
References:
Clinical trial NCT01019447: The Impact of Using Triclosan-antibacterial Sutures on the Incidence of Surgical Site Infection
Official title: "The Impact of Using Triclosan-antibacterial Sutures on the Incidence of Surgical Site Infection" Prospective, Randomized, Controlled, Double Blind, Multi-centre Study.
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE4
Conditions: Surgical Site Infection
Keywords: Surgical site infection
Antimicrobial triclosan-coated polyglactin 910 suture
Length of hospital stay
SSI
Lead sponsor: Cairo University
Sponsor class: OTHER
Collaborators: name: Amygate Healthcare
First posted: 2009-11-25
Enrollment: 701
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: PREVENTION

Brief summary: To compare conventional polyglactin 910 sutures with triclosan-coated polyglactin 910 antimicrobial sutures for the reduction of surgical site infections and any associated health and economic benefits.


Eligibility criteria: Inclusion Criteria:

* All patients of different age
* Gender
* Risk factors and procedures candidate for surgical intervention during the period of the study

Exclusion Criteria:

* Patients with an established pre-operative infection at the operative site

Primary outcomes:
measure: Signs of Surgical Site Infections (SSI) according to Centers for Disease Control (CDC) criteria
timeFrame: 30 days (or 1 year in case of prosthesis)
Secondary outcomes:
measure: Post-operative hospital stay in days
timeFrame: 30 days
Other outcomes:
Locations:
city: Cairo
country: Egypt
facility: Al-Zeraaein Hospital
city: Cairo
country: Egypt
facility: Cairo University Kasr Al-Aini Hospital
Study officials:
affiliation: Cairo University
name: Ibrahim Ga Ibrahim, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT03393247: The Therapy Effect of Azathioprine Initial or 14 Weeks After Combined With Infliximab on CD
Official title: The Therapy Effect of Azathioprine Initial or 14 Weeks After Combined With Infliximab on Crohn Disease：a Randomized, Open Label, Single-center Cohort Study
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Crohn Disease
Keywords: infliximab
azathioprine
Lead sponsor: Sixth Affiliated Hospital, Sun Yat-sen University
Sponsor class: OTHER
First posted: 2018-01-08
Enrollment: 160
Sex: ALL
Minimum age (years): 14
Maximum age (years): 60
Standard ages: CHILD
ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: This study aim to identify the therapeutic effect of azathioprine during infliximab(IFX) treatment in Crohn's disease (CD).Half of patients will receive azathioprine and infliximab combination therapy at the same time. The other half patients will be given infliximab therapy first and then receive azathioprine 14 weeks later.

Detailed description: Anti-tumor necrosis factor agents were widely used for many years and were proved to be most reliable drugs in Crohn's disease (CD). About one-third of the patients would develop a secondary lost of response after initiating IFX therapy in one year follow-up. Immunosuppressor was thought to be a useful agent to reduce loss of response rate of infliximab.But It remain unclear when should us add immunosuppressor during infliximab therapy.This study aim to find the most valuable timepoint to initiate combination therapy to maximize therapeutic effect and minimize the adverse effect.

Eligibility criteria: Inclusion Criteria:

- CD patients need infliximab and azathioprine combination therapy

Exclusion Criteria:

- patients had lost response to infliximab or azathioprine previously patients intolerable to infliximab or azathioprine patients need to use 5-Aminosalicylates(5-ASA) patients had participated to other clinical study in two months

Primary outcomes:
measure: loss of response(LOR) rate at one year
timeFrame: one year
Secondary outcomes:
measure: Simple Endoscopic Score for Crohn's Disease(SES-CD) at one year
timeFrame: one year
measure: Mucosal healing（MH）status at one year
timeFrame: one year
Other outcomes:
Locations:
city: Guangzhou
country: China
facility: The Sixth Affiliated Hospital, Sun Yat-sen University
state: Guangdong
Study officials:
affiliation: the 6th affiliated hospital of Sun Yat-sen university
name: Xiang Gao, doctor
role: STUDY_CHAIR
References:
Clinical trial NCT05557747: Cervicothoracic Junction Mobilization Versus Muscle Energy Technique in Chronic Neck Pain
Official title: Cervicothoracic Junction Mobilization Versus Autogenic Muscle Energy Technique in Patients With Chronic Mechanical Neck Pain
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Chronic Mechanical Neck Pain
Keywords: chronic mechanical neck pain
cervicothoracic junction mobilization
autogenic muscle energy technique
cervicothoracic junction hypomobility
Lead sponsor: Cairo University
Sponsor class: OTHER
First posted: 2022-09-28
Enrollment: 60
Sex: ALL
Minimum age (years): 18
Maximum age (years): 45
Standard ages: ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Intervention model description: 1. mobilization and conventional physical therapy
2. autogenic muscle Energy Technique and conventional physical therapy
3. conventional physical therapy only
Primary purpose: TREATMENT

Brief summary: This study will be conducted to identify the difference between the effect of of cervicothoracic junction mobilization and autogenic Muscle Energy Technique. on neck pain, cervical range of motion, cervical proprioception and neck disability in mechanical neck pain patients with cervicothoracic junction hypomobility.


Eligibility criteria: Inclusion criteria:

* Patients with a primary complaint of chronic neck pain (assessed by VAS )for more than 3 months
* Subjects with pain provocation and reduced mobility at the CT junction segment (assessed by passive accessory intervertebral movements (PAIVMs) and reduced mobility at cervical spine (assessed by CROM device.
* patients with age range from 18 to 45 years old.
* patients with body mass index less than 30 kg/m2.
* Exclusion Criteria:
* previous spine surgery
* pregnancy.
* Diabetic patients
* Hypertensive patients
* Patients were excluded if neck pain was associated with cervical radiculopathy
* whiplash injuries or severe headaches
* cervical spine fracture
* vertebro-basilar insufficiency.
* red flags suggesting of cancer, infection, vascular insufficiency
* Rheumatologic condition as mild systemic lupus erythematosus, poly-articular osteoarthritis, rheumatoid arthritis and advanced cervical spine degenerative diseases.

Primary outcomes:
measure: change in neck pain
timeFrame: Evaluation Will be performed prior to the first treatment session; as a baseline measure, and at last treatment session(after 4 weeks) as a post-treatment measure
Secondary outcomes:
measure: cervical ROM and cervical prorprioception
timeFrame: Evaluation Will be performed prior to the first treatment session; as a baseline measure, and at last treatment session(after 4 weeks) as a post-treatment measure
Other outcomes:
Locations:
city: Giza
country: Egypt
facility: FACULTY OF PHYSICAL THERAPY, cairo university
Study officials:
References:
Clinical trial NCT02255747: Anal Dilatation for Infants and Children With Constipation
Official title: Anal Dilatation for Infants and Children With Constipation
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Constipation
Keywords: infants and children with constipation
Lead sponsor: Tongji Hospital
Sponsor class: OTHER
First posted: 2014-10-03
Enrollment: 100
Sex: ALL
Minimum age (years): 1
Maximum age (years): 14
Standard ages: CHILD
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: This study is to evaluate the effect of anal dilation in infants and children with constipation.


Eligibility criteria: Inclusion Criteria:

1. Infants and Children With Constipation
2. Postoperative infants and children with Hirschsprung's disease
3. Good compliance

Exclusion Criteria:

1. Infants and Children With Constipation
2. Poor compliance

Primary outcomes:
measure: Daily stool times
timeFrame: two years
Secondary outcomes:
measure: The frequency of intestinal peristalsis waves
timeFrame: two years
measure: The amplitude of intestinal peristalsis waves
timeFrame: two years
Other outcomes:
Locations:
city: Wuhan
country: China
facility: Tongji Hospital
state: Hubei
Study officials:
affiliation: Tongji Hospital
name: Jiexiong, Feng
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT01687647: Sputum Cytometry Analysis in Lung Cancer Screening After Professional Asbestos Exposure
Official title: Interest of Morphometric Analysis of Sputum Cytology for Lung Cancer Screening in Workers Highly Exposed to Asbestos - Exploratory Analysis of Biomarkers Predictive for Lung Cancer
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: PHASE3
Conditions: Lung Neoplasms
Keywords: Lung cancer screening
Asbestos exposed workers
Sputum analysis
Automated cytometry
Predictive biomarkers
Lead sponsor: University Hospital, Caen
Sponsor class: OTHER
Collaborators: name: Ministry of Health, France
First posted: 2012-09-19
Enrollment: 1000
Sex: ALL
Minimum age (years): 56
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: SCREENING

Brief summary: Workers exposed to asbestos are at high risk of lung cancer. Medical follow-up of this population relies on repeated CT-scans which are more accurate for detection of peripheral lesions, and expose to X-rays and to risk of false-positives. Analysis of sputum using automate cytometry may be of interest in this population, alone or in combination with CT-scan.

An ancillary study will evaluate the interest of blood predictive biomarkers.


Eligibility criteria: Inclusion Criteria:

* High professional asbestos exposure
* Member of a former cohort recruited between 2000 and 2006 in Caen, Rouen and Le Havre (inclusion criteria: 50-75 years at the time of initial recruitment, high intermittent asbestos exposure \>= 1 year, or high discontinuous asbestos exposure \>=10 years). All the living members of the cohort will be contacted: a maximum of 1000 subjects is expected, probably less.
* Informed consent signed

Exclusion Criteria:

* Personal history of lung cancer
* Refusal of the study protocol
* Uncontrolled asthma or lung failure

Primary outcomes:
measure: Risk of false positive
timeFrame: within 3 months
measure: detection of lung cancer
timeFrame: within 3 months
Secondary outcomes:
measure: Sensitivity for lung cancer detection compared with CT-scan
timeFrame: within 3 months
measure: Specificity for detection of lung cancer
timeFrame: within 3 months
measure: Predictive Biomarkers
timeFrame: Annually during a maximum of 5 years
Other outcomes:
Locations:
city: Caen
country: France
facility: Caen University Hospital
city: Le Havre
country: France
facility: Le Havre Hospital
city: Rouen
country: France
facility: Rouen University Hospital
Study officials:
affiliation: Caen University Hospital, INSERM
name: Lydia GUITTET, MD,PhD
role: STUDY_DIRECTOR
References:
Clinical trial NCT05854147: Comparison of Effects of TT With and Without Visual and Auditory Cues for Freezing & Gait Patients With PD
Official title: Comparison of Effects of Treadmill Training With and Without Visual and Auditory Cues for Freezing & Gait in Patients With Parkinson's Disease
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Parkinson Disease
Lead sponsor: Superior University
Sponsor class: OTHER
First posted: 2023-05-11
Enrollment: 56
Sex: ALL
Minimum age (years): 45
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: HEALTH_SERVICES_RESEARCH

Brief summary: To determine the comparison of effects of treadmill training with and without visual and auditory cues for freezing and gait in patients with Parkinson's disease


Eligibility criteria: Inclusion Criteria:

* Patient who are clinically diagnosed with Parkinson Disease. Patients from both genders. Patients with age between 45 years and above. Patient with sufficient visual and auditory capacity to receive given cues will be included

Exclusion Criteria:

* Patients with the history of neurological deficit other than PD. Patients who need assistance for walking will be excluded. Patient with any peripheral vascular disease will be excluded. Patient with history of lower limb fracture.

Primary outcomes:
measure: Mini Mental Examination Scale MME
timeFrame: 6 Months.
Secondary outcomes:
Other outcomes:
Locations:
city: Lahore
country: Pakistan
facility: Shadman Medical Care
state: Punjab
Study officials:
References:
Clinical trial NCT01040247: Optimal Timing For Embryo Transfer For Low Responder Patients
Study type: INTERVENTIONAL
Overall status: TERMINATED
Phase: NA
Conditions: Infertility
Keywords: Infertility
Low Responder
IVF
Embryo Transfer
Lead sponsor: HaEmek Medical Center, Israel
Sponsor class: OTHER
First posted: 2009-12-29
Enrollment: 20
Sex: FEMALE
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: Women undergoing in vitro fertilization (IVF) therapy, who are low responder and agree to enter the trial will be randomized to a study group, for whom embryo transfer will be done on the same day as oocyte aspiration and fertilization; and a control group for whom embryo transfer will be performed 48 to 72 hours later, as is the current accepted practice.


Eligibility criteria: Inclusion Criteria:

* Patient undergoing IVF
* Number of mature oocytes equal to or lesser than the maximum number of embryos intended for transfer

Exclusion Criteria:

* Patient nor consenting

Primary outcomes:
measure: Pregnancy
timeFrame: 14 days
Secondary outcomes:
Other outcomes:
Locations:
city: Afula
country: Israel
facility: HaEmek Medical Center
Study officials:
References:
Clinical trial NCT04377347: Long-term Effects of Time to Treatment in Subarachnoid Haemorrhage
Official title: Time From First Health Care Contact to Neurosurgical Admission and the Effect on Long-term Labour Market Affiliation and Mortality in Patients With Spontaneous Subarachnoid Haemorrhage
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Spontaneous Subarachnoid Hemorrhage
Lead sponsor: Rigshospitalet, Denmark
Sponsor class: OTHER
First posted: 2020-05-06
Enrollment: 537
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: OTHER
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Patients that are retired or on social transfer payments the last three months before the sSAH are excluded from analyses on retirement and labour marked affiliation. However, they are included in mortality analyses. Also, patients aged 60 years or older are excluded in analyses of early retirement as reduced work capacity may to a higher degree result in early voluntary retirement.

Brief summary: For patients with spontaneous subarachnoid haemorrhage, it remains to be investigated if there is an association between the time from patients call the Emergence Medical Coordination Center to neurosurgical admission and long-term outcome.

This is a retrospective cohort study with four-year followup. The primary aim is to determine if the time to neurosurgical admission is associated to labour marked affiliation and mortality after four years.


Eligibility criteria: Inclusion Criteria:

* Spontaneous subarachnoid haemorrhage registered in the Danish National Patient Register and confirmed by medical record review.
* Initially admitted to a hospital in the Capital Region of Denmark between 1 January 2008 and 31 December 2014.

Exclusion Criteria:

* Prior subarachnoid haemorrhage.
* Inhospital symptom onset.

Primary outcomes:
measure: Labour marked affiliation and mortality
timeFrame: 4 years
Secondary outcomes:
Other outcomes:
Locations:
city: Copenhagen
country: Denmark
facility: Rigshospitalet
Study officials:
References:
Clinical trial NCT03294447: An Occupational Therapist Fall Prevention Intervention in a Geriatric Primary Care Setting
Official title: The Association Between Fear of Falling and Fall Prevention Interventions Offered by an Occupational Therapist in a Geriatric Primary Care Setting
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Fall Accident
Fall, Accidental
Keywords: Fear of falling
Lead sponsor: Rush University Medical Center
Sponsor class: OTHER
Collaborators: name: Western Michigan University
First posted: 2017-09-27
Enrollment: 13
Sex: ALL
Minimum age (years): 60
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: TREATMENT

Brief summary: Purpose of the study: To identify if an intervention focused on decreasing fear of falling (FOF) in a geriatric primary care setting implemented by an occupational therapist (OT) has the potential to decrease falls and improve physical, psychological and social factors related to FOF.

The primary research question: Is there an association between fear of falling among geriatric populations and fall prevention interventions that are offered by occupational therapist in a geriatric primary care setting?


Eligibility criteria: Inclusion Criteria:

* cognitively intact with a score of 29/30 or higher on the Orientation Log (standardized assessment tool)
* living in the community
* English speaking
* had a fall or near fall in the past year

Exclusion Criteria:

* received OT services within the past 2 months

Primary outcomes:
measure: The Change of Falls Efficacy Scale-International (FES-I), standardized measure for fear of falling
timeFrame: One Time visit: 30-50 minutes
Secondary outcomes:
Other outcomes:
Locations:
city: Chicago
country: United States
facility: Geriatric Primary Care Clinic
state: Illinois
Study officials:
affiliation: Rush University Medical Center
name: Lydia Royeen, Masters
role: PRINCIPAL_INVESTIGATOR
References: