Clinical trial NCT03786159: National Snapshot Study Adhesive Small Bowel Obstruction (ASBO)
Official title: Prospective Nationwide Audit of the Management of Adhesive Small Bowel Obstruction: a Snapshot Study
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Surgery-Induced Tissue Adhesion
Surgical Adhesions
Adhesion, Tissue
Lead sponsor: Radboud University Medical Center
Sponsor class: OTHER
First posted: 2018-12-24
Enrollment: 500
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: All patients with a suspicion of ASBO, older than 17 years, can be included in the present snapshot study. Patients with an episode of small bowel obstruction that is certainly not caused by adhesions fall outside of the scope of this study (eg. tumor as cause of SBO).

Brief summary: Over 63-90% of patients develop peritoneal adhesions after abdominal or pelvic surgery. Which makes it the most common complication after abdominal or pelvic surgery. Adhesions comprise a lifelong risk of adhesion related complications.The most frequent emergency complication of adhesion is an episode of adhesive small bowel obstruction (ASBO). Over 1 in 5 patients experiences at least 1 episode of ASBO in the 10 years following initial abdominal surgery. Despite the high incidence of ASBO, diagnosis and treatment of an episode of ASBO varies greatly between hospitals and even between doctors. Until now, optimal treatment patterns are unknown. The aim of this study is mapping of care for patients with a suspected episode of ASBO. With the collected data new hypothesis will be generated for the ideal diagnostic and therapeutic workflow for patients with a suspicion of an episode of ASBO.


Eligibility criteria: Inclusion Criteria:

* Suspicion ASBO
* Age 18 years or older

Exclusion Criteria:

* Clear other cause of small bowel obstruction (e.g. tumor, hernia)

Primary outcomes:
measure: CT treatment ASBO
timeFrame: February 2021
measure: Diagnostics ASBO
timeFrame: February 2021
measure: Timeframe conservative trial ASBO
timeFrame: February 2021
measure: Conservative trial > 72 hours ASBO
timeFrame: February 2021
measure: Laparoscopic surgery for ASBO
timeFrame: February 2021
measure: Outcome laparoscopic surgery for ASBO
timeFrame: February 2021
Secondary outcomes:
Other outcomes:
Locations:
city: Nijmegen
country: Netherlands
facility: Radboudumc
state: Gelderland
Study officials:
affiliation: Radboudumc, departement of surgery
name: Richard PG ten Broek, PhD, MD
role: STUDY_DIRECTOR
References:
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citation: Parker MC, Ellis H, Moran BJ, Thompson JN, Wilson MS, Menzies D, McGuire A, Lower AM, Hawthorn RJ, O'Briena F, Buchan S, Crowe AM. Postoperative adhesions: ten-year follow-up of 12,584 patients undergoing lower abdominal surgery. Dis Colon Rectum. 2001 Jun;44(6):822-29; discussion 829-30. doi: 10.1007/BF02234701.
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citation: Hershlag A, Diamond MP, DeCherney AH. Adhesiolysis. Clin Obstet Gynecol. 1991 Jun;34(2):395-402. doi: 10.1097/00003081-199106000-00023.
citation: Beck DE, Opelka FG, Bailey HR, Rauh SM, Pashos CL. Incidence of small-bowel obstruction and adhesiolysis after open colorectal and general surgery. Dis Colon Rectum. 1999 Feb;42(2):241-8. doi: 10.1007/BF02237135.